SAMN27615602
External Id
Shanghai Jiao Tong University School of Medicine
INSDC center name
2022-08-26T00:00:00Z
INSDC first public
2022-08-26T07:34:03.128Z
INSDC last update
SRS12641695
INSDC secondary accession
live
INSDC status
Model organism or animal
NCBI submission model
Model.organism.animal.1.0
NCBI submission package
SRS12641695
SRA accession
9-11 weeks
age
Sepsis associated encephalopathy (SAE) is a complex complication of sepsis and it brings abnormal emotional and memory dysfunctions and even increases the mortality of patients in the progression of sepsis. The alterations and abnormal functions of patients lays on the specific brain regions and possibly the hippocampus, which is one of the major brain regions responsible for the memory and emotional control. In the study, we determined to combine the combining RNA-seq-based transcriptomics and LC-MS-based metabolomics to comprehensively obtain the enriched genes and metabolites and their core network pathways in the LPS-injected SAE mice model with integrative analysis.
description
acute
disease_stage
WT
genotype
Mus musculus
http://purl.obolibrary.org/obo/NCBITaxon_10090
organism
Fertile
phenotype
Total RNA
sample_type
male
sex
C57BL6
strain
Hippocampus
tissue
Hippocampus from Mus musculus
title