SAMN26547115
External Id
Michigan State University
INSDC center name
2022-03-09T00:00:00Z
INSDC first public
2022-10-25T06:44:19.798Z
INSDC last update
SRS12231633
INSDC secondary accession
live
INSDC status
Plant
NCBI submission model
Plant.1.0
NCBI submission package
SRS12231633
SRA accession
Robin Buell
biomaterial provider
Plectranthus barbatus, also known as Coleus forskohlii or Indian coleus, is a tropical perennial medicinal shrub of the mint family (Lamiaceae) indigenous to the subtropical and temperate climate zones of India and southeast Asia. The plant has been used since ancient times in Hindu and Ayurvedic traditional medicine for treating a broad range of human health disorders. The main active compound of C. forskohlii is forskolin, a heterocyclic labdane-type diterpene found in the roots of the plant. The diverse known and potential pharmaceutical applications of forskolin extend from alleviation of glaucoma and anti-HIV or antitumor activities to treatment of hypertension and heart failure. The efficacy of forskolin relies on activation of the adenylate cyclase enzyme, leading to a marked increase of the intracellular level of cAMP (3-5-cAMP) in mammalian in vitro and in vivo systems. The semisynthetic forskolin derivative NKH477 has been approved for commercial use in Japan for treatment of cardiac surgery complications, heart failure, and cerebral vasospasm, while a forskolin eye drop solution was recently approved as an effective treatment for glaucoma.
description
mature Plant
dev_stage
USA: Michigan
geo loc name
Plectranthus barbatus
http://purl.obolibrary.org/obo/NCBITaxon_41228
organism
leaf
http://purl.obolibrary.org/obo/PO_0025034
tissue
Plectranthus barbatus, leaf
title