SAMN36287969
External Id
Shahid Beheshti University of Medical Sciences
INSDC center name
2023-07-04T00:00:00Z
INSDC first public
2023-07-04T06:05:06.378Z
INSDC last update
live
INSDC status
Human
NCBI submission model
Human.1.0
NCBI submission package
missing
age
missing
biomaterial_provider
MDA-MB-231
cell_line
missing
collection_date
Graphene-based materials have recently emerged as promising materials in cancer therapy. To find the molecular mechanisms and key regulatory molecules related to graphene-induced cytotoxicity used high throughput sequencing. In this study reduced graphene oxide-(L-lysine) was selected for a high-throughput investigation. Using mRNA-sequencing, 6 Giga base clean data (20 Million Reads, 150 base pair) per individual sample and totally 125.3 million reads of transcriptome sequence were generated. Gene expression study highlighted the behavior of the graphene oxide-derivate through reducing the expression of several genes involved in the cell migration, extracellular adhesion process, and cell connection. MDA-MB-231 cell line treated with 50 microg / mL of graphene oxide-(L-lysine) (3 sample) for 48 hours under anoikis condition and compare with 3 sample of control group (treated with DMEM containing 10% FBS).
description
missing
geo_loc_name
missing
isolate
Homo sapiens
http://purl.obolibrary.org/obo/NCBITaxon_9606
organism
missing
sex
Breast cancer
tissue
C3 MDA-MB-231 cell line
title