SAMN22843389
External Id
University of Prince Edward Island
INSDC center name
2022-02-28T00:50:40.410Z
INSDC first public
2022-08-31T10:44:21.597Z
INSDC last update
SRS14940522
INSDC secondary accession
live
INSDC status
MIGS.ba
NCBI submission model
MIGS/MIMS/MIMARKS.sediment
NCBI submission model
MIGS.ba.sediment.6.0
NCBI submission package
SRS14940522
SRA accession
2011-08-31
collection date
30
depth
The variable environmental conditions of marine habitats, including variations in hydrostatic pressure, temperature, and nutrient availability undoubtedly present significant challenges to the microbiota that live in the world's oceans. How marine bacteria adapt to these fluctuating conditions remains largely enigmatic. We hypothesize that temperature is a major driver of bacterial growth and development and hence adaptation in marine environments. Streptomyces have established inhabitants of marine habitats and well-known producers of bioactive metabolites. We hypothesize that temperature dependant regulation of bioactive metabolite production may represent an important adaptive strategy for marine streptomycetes. Bioactivity screening and metabolomic analysis of a library of streptomycetes isolated from intertidal sediments from Nunavut, Canada revealed several instances of low temperature induction of bioactive metabolite production. To elucidate the molecular mechanism underlying this phenomenon we are sequencing the genomes and transcriptomes of selected streptomycetes. We hypothesize that a novel regulatory mechanism underlies this phenomenon and that the results of this research can be used to access other cryptic natural products.
description
0
elev
marine sediment biome
env_broad_scale
Shoreline zone
env_local_scale
sediment
env_medium
Canada: Frobisher Bay, Nunavut
geo loc name
Marine Raffinose Histidine agar, 22dC
isol_growth_condt
marine sediment
isolation source
63.726118 N 68.424361 W
lat lon
1
num_replicons
Streptomyces sp. RKAG293
http://purl.obolibrary.org/obo/NCBITaxon_2893403
organism
no reference for the biomaterial
ref_biomaterial
RKAG293
strain
MIGS Cultured Bacterial/Archaeal sample from Streptomyces sp.
title