ERS4405586
SRA accession
Human
http://purl.obolibrary.org/obo/NCBITaxon_9606
common name
Adult asthmatic sample 28 - Adult asthma
description
Hungary
geographic location (country and/or sea)
Homo sapiens
http://purl.obolibrary.org/obo/NCBITaxon_9606
organism
Homo sapiens
http://purl.obolibrary.org/obo/NCBITaxon_9606
scientific name
Female
http://purl.obolibrary.org/obo/PATO_0000383
sex
Tie2, coded by the TEK gene, is a tyrosine kinase receptor and plays a central role in vascular stability. It was suggested that variations in the TEK gene might influence the susceptibility to asthma and allergic conjunctivitis. The aim of this study was to further investigate these suggestions, involving different populations and to study the Tie2 related pathway on a mouse model of asthma. In stage I, 113 SNPs were screened in the TEK gene of the patients in order to search for associations with asthma and allergic conjunctivitis. The top associated SNPs were selected for association studies on the replication cohorts.
submission description
GSB-5826
submission identifier
Investigation of the possible role of Tie2 pathway and TEK gene in asthma and allergic conjunctivitis
submission title