SAMN03760860
External Id
BC Cancer Agency
INSDC center name
2015-06-05T00:00:00Z
INSDC first public
2023-08-21T21:06:27.768Z
INSDC last update
SRS977980
INSDC secondary accession
live
INSDC status
Model organism or animal
NCBI submission model
Model.organism.animal.1.0
NCBI submission package
SRS977980
SRA accession
American bullfrog
common
Tadpoles undergo remarkable remodeling of the body plan in anticipation of the transition from an aquatic to a terrestrial lifestyle. The same hormone can have very different effects on tadpole tissues (for e.g. the tail disappears and the legs grow). We hypothesize that there are specific genes that contribute to these differences and we will identify them and examine the molecular switches that regulate how they work. Understanding this is important because it gives us fundamental information on how hormones can have very diverse effects and it gives us insight into why some tissues are more sensitive to environmental contaminants and how these contaminants could disturb hormone action. Since frogs are vertebrates and TH signaling is important in all vertebrates, the knowledge obtained by studying them can be easily applied to humans and, hence, will give us important clues in understanding the basis of diseases including cancer and metabolic disorders.
description
adult
http://www.ebi.ac.uk/efo/EFO_0001272
dev stage
Bruno
isolate
Aquarana catesbeiana
http://purl.obolibrary.org/obo/NCBITaxon_8400
organism
male
http://purl.obolibrary.org/obo/PATO_0000384
sex
liver
http://purl.obolibrary.org/obo/UBERON_0002107
tissue
Model organism or animal sample from Aquarana catesbeiana
title