SAMN38107858
External Id
Sichuan University
INSDC center name
2023-11-05T00:00:00Z
INSDC first public
2023-11-05T21:01:03.210Z
INSDC last update
live
INSDC status
Human
NCBI submission model
Human.1.0
NCBI submission package
11&16
age
ATCC
biomaterial_provider
Raji and Daudi
cell_line
2020-10
collection_date
Burkitt lymphoma (BL) is an exclusively high-grade and aggressive class of non-Hodgkin lymphomas. Lysine-specific demethylase 1 (LSD1), an epigenetic regulator, has become a potential target in cancer treatment. However, the biological role of LSD1 inhibitor in Burkitt lymphoma (BL) treatment needs to be further examined. Here we show that ZY0511, a novel LSD1 inhibitor, suppresses BL cells proliferation in vitro and in vivo in an LSD1-dependent manner. The RNA- seq study was executed utilizing Novogene Co. Ltd's (China) advanced profiling services. Post 48-hour exposure to either DMSO or ZY0511 at a concentration of 1 uM, we meticulously extracted the total RNA from Raji and Daudi cells, subsequently preserving it in TRIzol (Invitrogen, USA).
description
China
geo_loc_name
Raji and Daudi cells treatment with DMSO or ZY0511
isolate
Homo sapiens
http://purl.obolibrary.org/obo/NCBITaxon_9606
organism
not determined
sex
cell line
tissue
Human sample from Homo sapiens
title