SAMN36398121
External Id
Affiliated Hospital of Guizhou Medical University
INSDC center name
2023-09-01T00:00:00Z
INSDC first public
2023-09-01T10:28:01.700Z
INSDC last update
SRS18253177
INSDC secondary accession
live
INSDC status
Model organism or animal
NCBI submission model
Model.organism.animal.1.0
NCBI submission package
SRS18253177
SRA accession
over 6 months
age
2022-04-22/2022-05-10
collection_date
60 SD rats were randomly divided into 5 groups, including control group, lithium-pilocarpine chronic epilepsy model group, levetiracetam(150mg/kg) group, levetiracetam(150mg/kg) combined with sodium oligomannate(25mg/kg) group, levetiracetam(150mg/kg) combined with sodium oligomannate(50mg/kg) intervention group. After the model was successfully established, the rats in each group were evaluated for cognitive behavioral baseline by Y maze. After the baseline evaluation, treatment were given for 3 months, while the control group and the model group reeived the same volume of normal saline. After 3 months, seizures in each group were monitored by video. The Morris water maze test was used to evaluate the cognitive function, and the light-dark box test, the forced swimming test and the tail suspension test were used to evaluate the emotion of rats. Rat feces were analyzed by 16S rRNA sequencing. The blood routine, liver and kidney function in each group were detected.
description
China:GuiZhou
geo_loc_name
gut metagenome
http://purl.obolibrary.org/obo/NCBITaxon_749906
organism
male
sex
intestinal flora
strain
not provided
tissue
Model organism or animal sample from gut metagenome
title