SAMN38862073
External Id
University of New Mexico
INSDC center name
2023-12-16T00:00:00Z
INSDC first public
2023-12-16T13:01:20.450Z
INSDC last update
live
INSDC status
Human
NCBI submission model
Human.1.0
NCBI submission package
ERS17917921
SRA accession
0 to 60 months
age
Douglas J Perkins, University of New Mexico Center for Global Health, MSC10 5550, 1 University of New Mexico, Albuquerque, NM 87131
biomaterial_provider
2018-01-01/2023-12-16
collection_date
Severe, life-threatening malaria presents acutely with various clinical symptoms such as impaired consciousness, convulsions, anemia, respiratory distress, and more. Finding shared gene pathways or networks that explain these diverse symptoms has been challenging because different biological processes might not have common shared networks. The overall goal of the project is to identify critical gene pathways within the transcriptome that mediate disease severity in children with acute Plasmodium falciparum malaria. Specifically, we aim to determine how gene pathways and networks promote the development of severe malarial anemia. This study is comparing the entire expressed transcriptome captured in whole blood from children with severe malarial anemia [SMA, hemoglobin <6.0 g/dL in the presence of P. falciparum in peripheral blood (any density)] versus those with non-SMA [hemoglobin >6.0 g/dL in the presence of P. falciparum in peripheral blood (any density)].
description
malaria
disease
acute
disease_stage
African
ethnicity
Kenya: Siaya
geo_loc_name
acute malaria
health_state
peripheral whole blood
isolate
Homo sapiens
http://purl.obolibrary.org/obo/NCBITaxon_9606
organism
SMA/non-SMA
phenotype
human
population
Black African
race
peripheral blood
sample_type
pooled male and female
sex
periheral blood
tissue
Whole blood transcriptome in children with Plasmodium falciparum infection
title
none
treatment