SAMN38845012
External Id
Guangzhou University of Chinese Medicine
INSDC center name
2023-12-14T00:00:00Z
INSDC first public
2023-12-15T09:08:37.263Z
INSDC last update
SRS19869234
INSDC secondary accession
live
INSDC status
Metagenome or environmental
NCBI submission model
Metagenome.environmental.1.0
NCBI submission package
SRS19869234
SRA accession
2022-09-28
collection_date
To reveal the role of gut microbiota in the protective effects of Wushen Decoction (WST) on heart failure (HF), a myocardial infarction (MI)-induced HF mouse model was established with or without WST (36g/kg/d) administration. Mice that underwent the same surgery but without ligating left anterior descending coronary artery treated with vehicle were used as sham group. Faecal samples from mice in Sham, HF and WST group were collected and measured by 16S rRNA sequencing. The results showed that Wushen Decoction reverses gut microbial dysbiosis of post-MI HF mice. In addition, the founding implied that the WST-induced alteration of gut microbiota might be related to immune modulation.
description
China:Guangdong
geo_loc_name
Guangzhou
isolation_source
24 N 113 E
lat_lon
mouse gut metagenome
http://purl.obolibrary.org/obo/NCBITaxon_410661
organism
Mouse metagenomic isolated from feces of mouse with myocardial infarction
title