characteristics.text: ERC000047
characteristics.characteristic: ENA-CHECKLIST
characteristics.text: 2023-01-19T12:17:26Z
characteristics.characteristic: ENA-FIRST-PUBLIC
characteristics.text: 2023-01-19T12:17:26Z
characteristics.characteristic: ENA-LAST-UPDATE
characteristics.text: SAMEA112229463
characteristics.characteristic: External Id
characteristics.text: EMG
characteristics.characteristic: INSDC center name
characteristics.text: 2023-01-19T12:17:26Z
characteristics.characteristic: INSDC first public
characteristics.text: 2023-01-19T12:17:26Z
characteristics.characteristic: INSDC last update
characteristics.text: public
characteristics.characteristic: INSDC status
characteristics.text: ERS14340362
characteristics.characteristic: SRA accession
characteristics.text: SRR15604600_bin.10_metawrap_v1.3_MAG
characteristics.characteristic: Submitter Id
characteristics.text: Many fragments with little to no review of assembly other than reporting of standard assembly statistics
characteristics.characteristic: assembly quality
characteristics.text: not provided
characteristics.characteristic: assembly software
characteristics.text: MaxBin2, MetaBat2, Concoct with default parameter of the metaWRAP pipeline. Bin refinement module used from metaWRAP with default parameters.
characteristics.characteristic: binning parameters
characteristics.text: metawrap v1.3
characteristics.characteristic: binning software
characteristics.text: mouse digestive system
characteristics.characteristic: broad-scale environmental context
characteristics.text: EBI-EMG
characteristics.characteristic: broker name
characteristics.text: 2019-11-18
characteristics.characteristic: collection date
characteristics.text: 83.54
characteristics.unit: %
characteristics.characteristic: completeness score
characteristics.text: CheckM
characteristics.characteristic: completeness software
characteristics.text: 2.2
characteristics.unit: %
characteristics.characteristic: contamination score
characteristics.text: This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run SRR15604600 of study SRP334008.
characteristics.characteristic: description
characteristics.text: feces
characteristics.characteristic: environmental medium
characteristics.text: China
characteristics.characteristic: geographic location (country and/or sea)
characteristics.text: 40.51
characteristics.unit: DD
characteristics.characteristic: geographic location (latitude)
characteristics.text: 110.178
characteristics.unit: DD
characteristics.characteristic: geographic location (longitude)
characteristics.text: metagenome-assembled genome
characteristics.characteristic: investigation type
characteristics.text: mouse gut metagenome
characteristics.characteristic: isolation_source
characteristics.text: digestive tube
characteristics.characteristic: local environmental context
characteristics.text: mouse gut metagenome
characteristics.characteristic: metagenomic source
characteristics.text: uncultured Erysipelotrichaceae bacterium
characteristics.characteristic: organism
characteristics.text: To evaluate the role of probiotics in restoring the antibiotic-destroyed gut microbiota and efficacy of ICB therapies, we studied the effect of Lactobacillus rhamnosus Probio-M9 combined with anti-PD-1 on mouse colon cancer and the dynamic changes of gut microbiome by metagenome analyses. The results showed that the combination of Probio-M9 significantly improved tumor inhibition compared with ICB therapy alone in antibiotics treated mice, which could be attribute to the upregulated microbial diversity and increased abundance of beneficial bacteria such as Bifidobacterium pseudolongum, Parabacteroides distasonis and some species of Bacteroides after Probio-M9 supplemented. These changes of structure and composition in gut microbiota caused the alternation of microbiome function, of which the sugar degradation, vitamin and amino acid synthesis pathways were significantly enriched. Collectively, this study indicated that Probio-M9 enhanced the host&apos;s immunotherapeutic response by promoting the colonization of beneficial bacteria and improving intestinal function.
characteristics.characteristic: project name
characteristics.text: SAMN20968520
characteristics.characteristic: sample derived from
characteristics.text: uncultured Erysipelotrichaceae bacterium
characteristics.characteristic: scientific_name
characteristics.text: Illumina HiSeq 2500
characteristics.characteristic: sequencing method
characteristics.text: The taxonomy of this metagenome-assembled genome was originally computed with GTDBtk, which assigned the following taxonomic annotation: d__Bacteria;p__Firmicutes;c__Erysipelotrichia;o__Erysipelotrichales;f__Erysipelotrichaceae;g__;s__
characteristics.characteristic: taxonomic classification
characteristics.text: multi-marker approach
characteristics.characteristic: taxonomic identity marker
characteristics.text: Metagenome-assembled genome: SRR15604600_bin.10_metawrap_v1.3_MAG
characteristics.characteristic: title