ERC000011
ENA-CHECKLIST
2023-12-01T00:42:24Z
ENA-FIRST-PUBLIC
2023-12-01T00:42:24Z
ENA-LAST-UPDATE
SAMEA112772778
External Id
QCIF Facility for Advanced Bioinformatics, Institute for Molecular Bioscience, The University of Queensland, Australia
INSDC center name
2023-12-01T00:42:24Z
INSDC first public
2023-12-01T00:42:24Z
INSDC last update
public
INSDC status
ERS14773577
SRA accession
E-MTAB-12767:HG_1.3
Submitter Id
58
year
age
ArrayExpress
broker name
spatial
cell_type
non-obese, non diabetic, ex-smoker
clinical history
Open right nephrectomy. Ipilimumab/ nivolumab C1 (ceased due to colitis + dermatitis). Nivolumab C5 (ceased due to colitis) SBRT to left pleural based metastasis.
clinical information
human
common name
Protocols: To profile the transcriptome within the ccRCC TME, we performed ST-seq on ten fresh frozen tissue sections collected in the operating theatre from six patients with ccRCC (n = 2 para-tumour, n = 4 low-grade and n = 4 high-grade) presenting at a tertiary referral hospital from June 2021 to January 2022 (Fig. 1A). Additional clinical characteristics of the ccRCC patients at presentation include patient LG_2 with a vena cava thrombus (VCT); patient HG_1 with pleural metastases; and patient HG_3 with a third recurrent lesion (Table 1). Furthermore, for patients HG_1 and HG_3, para-tumour (pTME) tissue was collected from adjacent surgically normal margin. All six patients provided informed consent and this study received ethics approval from Metro South Human Research Ethics Committee (Reference Number HREC/16/QPAH/353 and HREC/12/QPAH/125). ST libraries were prepared by Visium Spatial Gene Expression Reagent Kits ST libraries were prepared by Visium Spatial Gene Expression Reagent Kits
description
adult
developmental stage
renal cell carcinoma
disease
G4; pT3a
disease staging
HG 1
individual
not applicable
isolate
Homo sapiens
organism
Homo sapiens
organism
kidney
organism part
Homo sapiens
scientific_name
male
sex
HG_1.3
title
125
millimeter
tumor size