2024-06-29
ENA first public
ERC000011
ENA-CHECKLIST
SAMEA110195128
External Id
SAMSUNG MEDICAL CENTER
INSDC center name
2022-06-29T05:29:08Z
INSDC last update
public
INSDC status
ERS12292803
SRA accession
SMC_TMP_0164
Submitter Id
human
common name
Lung adenocarcinoma is one of the most common cancer types with various treatment modalities. However, better biomarkers to predict therapeutic response are still needed to improve precision medicine. S3 was characterized by dependency on CDK4, immune-related expression patterns, and altered MET signaling; experimental validation showed that S3-associated cell lines responded to MET inhibitors, leading to increased PD-L1 expression. Patients with S3 tumors were also enriched with responders to immune checkpoint blockade (ICB) in a real world patient dataset. We further identified genomic features in S3 and S166 as biomarkers for enabling clinical diagnosis of these subtypes.
description
eukaryote
investigation type
Homo sapiens
organism
PRJEB53958
project name
Homo sapiens
scientific_name
NGS
sequencing method
High-resolution lung adenocarcinoma expression subtypes
title