2024-09-19
ENA first public
ERC000050
ENA-CHECKLIST
EMBL Heidelberg
INSDC center name
public
INSDC status
ERS21055858
SRA accession
spire_mag_00064898
Submitter Id
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly quality
megahit 1.2.9
assembly software
default
binning parameters
metabat 2.12.1
binning software
human digestive system
broad-scale environmental context
EBI-EMG
broker name
2016
collection date
95.12
%
completeness score
checkm2 0.1.3
completeness software
1.06
%
contamination score
This sample represents a Third Party Annotation (TPA) binned metagenome assembled from the metagenomic run ERR2855792 of study ERP111403.
description
stool
environmental medium
not provided
geographic location (country and/or sea)
34.27000000
DD
geographic location (latitude)
108.93000000
DD
geographic location (longitude)
metagenome-assembled genome
investigation type
human gut metagenome
isolation_source
human gut
local environmental context
human gut metagenome
metagenomic source
Phocaeicola vulgatus
organism
The gut-brain axis has been enthusiastically discussed in recent years. Gut bacteria are known to promote serotonin biosynthesis from colonic enterochromaffin cells1. Germ-free mice are also known to have impaired blood-brain barrier, which could be rescued by short-chain fatty acids2. However, there has been little evidence from human studies, not to mention a study that combined human cohorts with animal models. Here we provide metagenomic shotgun sequencing data for a typical psychiatric disease, schizophrenia, for which tens of thousands of samples have been characterized in genome-association studies (GWAS). Metagenome-wide association studies (MWAS) identified bacteria that differ between patients and controls, which was partially recapitulated in mice transplanted with the human faeces. We show that the schizophrenic gut microbiome was causally responsible for core symptoms such as psychomotor hyperactivity and impaired learning and memory, whereas non-specific symptoms such as anxiety were lost in the mice model. Our findings pave the road for better diagnosis as well as mechanistic understandings of this devastating disease.
project name
SAMEA4968195
sample derived from
Phocaeicola vulgatus
scientific_name
HiSeq X Ten
sequencing method
multi-marker approach
taxonomic identity marker
binned metagenome: spire_mag_00064898
title