2024-09-20
ENA first public
ERC000050
ENA-CHECKLIST
EMBL Heidelberg
INSDC center name
public
INSDC status
ERS21062861
SRA accession
spire_mag_01767172
Submitter Id
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly quality
megahit 1.2.9
assembly software
default
binning parameters
metabat 2.12.1
binning software
human digestive system
broad-scale environmental context
EBI-EMG
broker name
missing: third party data
collection date
100
%
completeness score
checkm2 0.1.3
completeness software
0.16
%
contamination score
This sample represents a Third Party Annotation (TPA) binned metagenome assembled from the metagenomic run SRR7280863 of study SRP150069.
description
stool
environmental medium
not provided
geographic location (country and/or sea)
missing: third party data
DD
geographic location (latitude)
missing: third party data
DD
geographic location (longitude)
metagenome-assembled genome
investigation type
human gut metagenome
isolation_source
human gut
local environmental context
human gut metagenome
metagenomic source
Phocaeicola vulgatus
organism
Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child’s life. We identified mother-to-child microbial transmission events and describe the incidence of family-specific antibiotic resistance genes. Across multiple species, we identified two inheritance patterns, where often the mother’s dominant strain is transmitted to the child, but occasionally her minor strains colonize the infant gut. We observed both inheritance patterns for Bacteroides uniformis strains. In families where the minor strain was inherited, we identified a starch utilization gene cluster that was absent in the mother’s dominant strain, suggesting the selective advantage of her minor strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high-resolution and give insights into early colonization of the infant gut.
project name
SAMN09382680
sample derived from
Phocaeicola vulgatus
scientific_name
Illumina HiSeq 2500
sequencing method
multi-marker approach
taxonomic identity marker
binned metagenome: spire_mag_01767172
title