2024-09-20
ENA first public
ERC000050
ENA-CHECKLIST
EMBL Heidelberg
INSDC center name
public
INSDC status
ERS21064359
SRA accession
spire_mag_02475259
Submitter Id
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly quality
megahit 1.2.9
assembly software
default
binning parameters
metabat 2.12.1
binning software
human digestive system
broad-scale environmental context
EBI-EMG
broker name
2017
collection date
89.25
%
completeness score
checkm2 0.1.3
completeness software
7.61
%
contamination score
This sample represents a Third Party Annotation (TPA) binned metagenome assembled from the metagenomic run SRR15032393 of study SRP326733.
description
stool
environmental medium
USA
geographic location (country and/or sea)
37.42750000
DD
geographic location (latitude)
-122.16970000
DD
geographic location (longitude)
metagenome-assembled genome
investigation type
human gut metagenome
isolation_source
human gut
local environmental context
human gut metagenome
metagenomic source
Phocaeicola vulgatus
organism
Diet modulates the gut microbiome, which, in turn, can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber or fermented foods, influence the human microbiome and immune system in healthy adults. Using a 17-week randomized, prospective study (n = 18/arm) combined with -omics measurements of microbiome and host, including extensive immune profiling, we found diet-specific effects. The high-fiber diet increased microbiome-encoded glycan-degrading CAZymes despite stable microbial community diversity. While Cytokine Response Score (primary outcome) was unchanged, three distinct immunological trajectories in high fiber-consumers corresponded to baseline microbiota diversity. Alternatively, the high-fermented food diet steadily increased microbiota diversity and decreased inflammatory markers. The data highlight how coupling dietary interventions to deep and longitudinal immune and microbiome profiling can provide individualized and population-wide insight. Fermented foods may be valuable in countering the decreased microbiome diversity and increased inflammation pervasive in industrialized society.
project name
SAMN20031434
sample derived from
Phocaeicola vulgatus
scientific_name
Illumina MiSeq
sequencing method
multi-marker approach
taxonomic identity marker
binned metagenome: spire_mag_02475259
title