2024-09-20
ENA first public
ERC000050
ENA-CHECKLIST
EMBL Heidelberg
INSDC center name
public
INSDC status
ERS21063314
SRA accession
spire_mag_01891107
Submitter Id
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly quality
megahit 1.2.9
assembly software
default
binning parameters
metabat 2.12.1
binning software
human digestive system
broad-scale environmental context
EBI-EMG
broker name
2009/2013
collection date
94.43
%
completeness score
checkm2 0.1.3
completeness software
0.15
%
contamination score
This sample represents a Third Party Annotation (TPA) binned metagenome assembled from the metagenomic run ERR3277296 of study ERP114775.
description
not specified
environmental medium
Canada
geographic location (country and/or sea)
49.28270000
DD
geographic location (latitude)
-123.12070000
DD
geographic location (longitude)
metagenome-assembled genome
investigation type
human gut metagenome
isolation_source
human gut
local environmental context
human gut metagenome
metagenomic source
Phocaeicola vulgatus
organism
Allergic disease is the most frequent chronic health issue in children and has been linked to early life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance. We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, prior to their developing allergic disease. We found that the microbiome of infants that went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production. Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against development of allergies and suggest metabolite therapy as a potential prevention strategy.
project name
SAMEA5564420
sample derived from
Phocaeicola vulgatus
scientific_name
NextSeq 500
sequencing method
multi-marker approach
taxonomic identity marker
binned metagenome: spire_mag_01891107
title