2024-09-20
ENA first public
ERC000050
ENA-CHECKLIST
EMBL Heidelberg
INSDC center name
public
INSDC status
ERS21063283
SRA accession
spire_mag_01874976
Submitter Id
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly quality
megahit 1.2.9
assembly software
default
binning parameters
metabat 2.12.1
binning software
human digestive system
broad-scale environmental context
EBI-EMG
broker name
2012-10-05
collection date
81.83
%
completeness score
checkm2 0.1.3
completeness software
7.04
%
contamination score
This sample represents a Third Party Annotation (TPA) binned metagenome assembled from the metagenomic run SRR3730397 of study SRP076119.
description
stool
environmental medium
USA
geographic location (country and/or sea)
40.82900000
DD
geographic location (latitude)
-96.66700000
DD
geographic location (longitude)
metagenome-assembled genome
investigation type
human gut metagenome
isolation_source
human gut
local environmental context
human gut metagenome
metagenomic source
Phocaeicola vulgatus
organism
Live bacteria have been used for decades in an attempt to modulate the human gut microbiota, but their colonization is mostly transient, and a conceptual understanding of the ecological role of exogenous microbes in gut ecosystems is lacking. Here we show that Bifidobacterium longum AH1206 stably persists in the gut of one third of human individuals for at least six months after being orally administered without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. Engraftment of AH1206 was associated with low abundance of B. longum and specific carbohydrate utilization genes of this species in the pre-treatment microbiome. This pointed to inter-individual differences in the availability of resources that constitute a niche opportunity for colonization. The findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precision microbiome reconstitution and a personalization of such strategies.
project name
SAMN05194706
sample derived from
Phocaeicola vulgatus
scientific_name
Illumina MiSeq
sequencing method
multi-marker approach
taxonomic identity marker
binned metagenome: spire_mag_01874976
title