SAMN41994391
External Id
Wuhan university
INSDC center name
2024-12-13T00:00:00Z
INSDC first public
2024-12-13T07:35:01.960Z
INSDC last update
SRS21832933
INSDC secondary accession
live
INSDC status
Human
NCBI submission model
Human.1.0
NCBI submission package
SRS21832933
SRA accession
not applicable
age
ATCC
biomaterial_provider
Lovo cell lines
cell_line
not applicable
collection_date
Stanniocalcin-2 (STC2), a glycosylated protein discovered in the endocrine glands of fish, has been shown to play multiple cell biological roles in cancers. However, the function and specific mechanism of STC2 in colorectal cancer (CRC) remain unclear. Herein, bioinformatics analysis and CRC tissue specimens were used to investigated the expression and prognostic value of STC2. Flow cytometry, sphere formation and Dead/Live staining assay were used to examine the biological functions of STC2, and the specific mechanism was explored using RNA sequencing, RNA immunoprecipitation (RIP) assays and RNA stability assay. In this study, we found that STC2 was upregulated in CRC, and its highly expression was correlated with poor prognosis in CRC patients. STC2 could promote resistance to anoikis in CRC, which through upregulating TGIF1 expression. Mechanistically, we found that STC2 regulated TGIF1 by binding to the mRNA of TGIF1 which repressing its degradation. Our study revealed that STC2 could be a potential therapeutic target for CRC treatment and provide potential new insights into the strategy of CRC treatment.
description
not applicable
geo_loc_name
the American Type Culture Collection (ATCC, USA)
isolate
Homo sapiens
http://purl.obolibrary.org/obo/NCBITaxon_9606
organism
not provided
sex
CRC
tissue
Human sample from Homo sapiens
title