SAMN37643946
External Id
The First Affiliated Hospital of Henan University of Science and Technology
INSDC center name
2024-11-30T00:50:20.667Z
INSDC first public
2024-11-30T00:50:20.667Z
INSDC last update
live
INSDC status
Metagenome or environmental
NCBI submission model
Metagenome.environmental.1.0
NCBI submission package
ERS22908592
SRA accession
10-80
age
Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China
biomaterial_provider
2023-04-10
collection_date
Carbapenem-resistant Enterobacterales (CRE) is a global concern. This study investigated the prevalence of fecal colonization carriage and clonal dissemination of CRE among population in four provinces of China. Stool samples were collected from four provinces in China. The overall fecal carriage rate was 9.6% (66/685). The highest prevalence was in Henan province (18.35%, 95% CI: 9%-18.7%). Sixty-six CRE isolates were identified in Escherichia coli (56.06%, 37/66), Klebsiella (15.15%, 10/66), Citrobacter (13.63%, 9/66), Enterobacter (12.12%, 8/66), and Atlantibacter (1.51%, 1/66). Each CRE strain harbored carbapenemase genes and multiple antibiotics resistance genes. blaNDM-5 (77.27%, 51/66) was the most common, followed by blaNDM-1 (19.69%, 13/66). All CRE isolates belonged to different sequence types (STs). ST206 (14/38) E. coli and ST2270 (6/10) Klebsiella were significantly dominant clones. The results indicated the rising prevalence of CRE fecal carriage among healthy adults of China, mostly blaNDM-producing E coli. Screening for CRE colonization is necessary to control infection.
description
China
geo_loc_name
Homo sapiens
host
feces
isolation_source
missing
lat_lon
human gut metagenome
http://purl.obolibrary.org/obo/NCBITaxon_408170
organism
pooled male and female
sex
Metagenome or environmental sample from human gut metagenome
title