SAMN38083828
External Id
University of California
INSDC center name
2024-09-12T00:00:00Z
INSDC first public
2024-09-19T15:18:30.225Z
INSDC last update
SRS19409804
INSDC secondary accession
live
INSDC status
Microbe, viral or environmental
NCBI submission model
Microbe.1.0
NCBI submission package
SRS19409804
SRA accession
2022
collection_date
This Babesia species, which was linked to several severe cases of human babesiosis in midwestern United States, was previously determined to be closely related to B. divergens, the major agent of human babesiosis in Europe. However, it remained uncertain whether these two pathogens are different variants of the same species or if they belong to entirely separate species. Here we provide evidence that this species represents a separate species of Babesia that infect humans. We found that although both species share similar genome sizes, comprising three nuclear chromosomes, one linear mitochondrial chromosome, and one circular apicoplast chromosome, they exhibit significant differences in gene functions, transcriptional and epigenetic regulations, replication rates, and susceptibility to antiparasitic drugs. Additionally, both species express distinct classes of multigene families, which are likely crucial for their adaptation to the mammalian host. Collectively, our data endorse the classification of this babesia as a novel species and we suggest designating it as Babesia goethfordi.
description
USA: New Haven, Connecticut
geo_loc_name
Homo sapiens
host
Babesia sp. MO1
http://purl.obolibrary.org/obo/NCBITaxon_3348907
organism
cell culture
sample_type
MO1
strain
Babesia goethfordi F12 clone
title