characteristics.text: SAMN40180237
characteristics.characteristic: External Id
characteristics.text: Kazakh National Agrarian Research University
characteristics.characteristic: INSDC center name
characteristics.text: 2024-03-14T00:00:00Z
characteristics.characteristic: INSDC first public
characteristics.text: 2024-03-14T23:47:02.024Z
characteristics.characteristic: INSDC last update
characteristics.text: live
characteristics.characteristic: INSDC status
characteristics.text: Viral
characteristics.characteristic: NCBI submission model
characteristics.text: Virus.1.0
characteristics.characteristic: NCBI submission package
characteristics.text: ERS18501181
characteristics.characteristic: SRA accession
characteristics.text: 2024-01-05
characteristics.characteristic: collection_date
characteristics.text: From December 28, 2023, to January 09, 2024, an outbreak of HPAI (Outbreak ID: ob_129664) among swans occurred around Lake Karakol near the coast of the Caspian Sea in Mangistau Oblast, Republic of Kazakhstan (Latitude: 43.438; Longitude: 51.3331). A total of 227 dead carcasses of mute swans were detected, which were tested by the National Reference Veterinary Center using PCR to detect subtype H5 (N untyped) of the avian influenza virus [WAHIS, report]. For further detailed investigation, 12 samples of pathological organs from four dead swans were sent to the International Center for Vaccinology of the Kazakh National Agrarian Research University (KazNARU). All study procedures were approved by the Commission on Bioethics of KazNARU (dated 15 January 2024). Based on virologic studies, hemagglutinating agents were detected in the hemagglutination assay [WOAH, 2021] in 9 out of 12 pathologic organ samples (lungs, trachea, liver, heart) of four swans on 10-day-old embryonated chicken eggs (ECEs). In Kazakhstan-Japan Innovation Center of KazNARU, further genetic analysis of one specimen (ID # 1-S24R-2, swan #2, lung, first passage in ECEs) showed that the isolated strain A/mute swan/Mangystau/1-S24R-2/2024 belongs to avian influenza virus of subtype H5N1, clade 2.3.4.4b, with the HPAI pathotype confirmed by the PLREKRRKRGLF cleavage site in HA gene [Tabynov, 2006].
characteristics.characteristic: description
characteristics.text: Kazakhstan
characteristics.characteristic: geo_loc_name
characteristics.text: Mute swan
characteristics.characteristic: host
characteristics.text: 1-S24R-2
characteristics.characteristic: isolate
characteristics.text: Wild bird
characteristics.characteristic: isolation_source
characteristics.text: Influenza A virus
characteristics.ontologyTerms: http://purl.obolibrary.org/obo/NCBITaxon_11320
characteristics.characteristic: organism
characteristics.text: A/mute swan/Mangystau/1-S24R-2/2024 (H5N1)
characteristics.characteristic: title