characteristics.text: SAMN40863352
characteristics.characteristic: External Id
characteristics.text: China Academy of Chinese Medical Sciences
characteristics.characteristic: INSDC center name
characteristics.text: 2024-04-10T00:00:00Z
characteristics.characteristic: INSDC first public
characteristics.text: 2024-04-10T14:11:31.905Z
characteristics.characteristic: INSDC last update
characteristics.text: live
characteristics.characteristic: INSDC status
characteristics.text: Model organism or animal
characteristics.characteristic: NCBI submission model
characteristics.text: Model.organism.animal.1.0
characteristics.characteristic: NCBI submission package
characteristics.text: ERS18922989
characteristics.characteristic: SRA accession
characteristics.text: 30 weeks
characteristics.characteristic: age
characteristics.text: 2023-07-26
characteristics.characteristic: collection_date
characteristics.text: Aging is a pressing global concern, frequently accompanied by the emergence of chronic illnesses. Xiyangshen Sanqi Danshen granules (XSD) have antioxidant, anti-inflammatory and anti-fatigue functions, but the mechanism of their anti-aging functions is not clear. To elucidate the mechanism by which XSD delays D-galactose-induced aging in mice. An investigation was conducted to establish an aging model using C57BL/6J mice through the injection of D-galactose intraperitoneally at a dosage of 0.25 g/kg/d. Meanwhile, we set up Control group, D-gal group, MT group (10 mg/kg/d), D-gal+XSDL group(0.2245 g/kg/d), D-gal+XSDM group (0.6734 g/kg/d) and D-gal+XSDH group (2.02 g/kg/d). Transcriptome sequencing was performed on the brain tissues of control group, D-gal group and D-gal+XSDH group to observe the differentially expressed genes so as to clarify the anti-aging mechanism of XSD.
characteristics.characteristic: description
characteristics.text: China: Beijing
characteristics.characteristic: geo_loc_name
characteristics.text: Mus musculus
characteristics.ontologyTerms: http://purl.obolibrary.org/obo/NCBITaxon_10090
characteristics.characteristic: organism
characteristics.text: male
characteristics.characteristic: sex
characteristics.text: C57BL/6J
characteristics.characteristic: strain
characteristics.text: Brain
characteristics.characteristic: tissue
characteristics.text: Xiyangshen Sanqi Danshen granules attenuated D-gal induced C57BL/6J mice aging through AMPK/SIRT1 signaling pathway
characteristics.characteristic: title