characteristics.text: SAMN41761849
characteristics.characteristic: External Id
characteristics.text: Tongji medical school
characteristics.characteristic: INSDC center name
characteristics.text: 2024-06-10T00:00:00Z
characteristics.characteristic: INSDC first public
characteristics.text: 2024-06-10T17:50:13.969Z
characteristics.characteristic: INSDC last update
characteristics.text: live
characteristics.characteristic: INSDC status
characteristics.text: Model organism or animal
characteristics.characteristic: NCBI submission model
characteristics.text: Model.organism.animal.1.0
characteristics.characteristic: NCBI submission package
characteristics.text: ERS23036481
characteristics.characteristic: SRA accession
characteristics.text: 0-21 days
characteristics.characteristic: age
characteristics.text: C57BL/6J-Knock-out (KO-lacking CD209 (CD209-/-)) mice
characteristics.characteristic: breed
characteristics.text: 2023
characteristics.characteristic: collection_date
characteristics.text: Emerging evidence highlights a significant association between early-life gut microbiota composition and the development of chronic diseases later in life. The postnatal period plays a crucial role in shaping the composition of the gut microbiota, establishing microbe-host interactions, and maintaining immune balance. However, the specific molecular mechanisms responsible for this neonatal priming period have yet to be elucidated. Multiple innate immune receptors actively participate in shaping the gut microbiota during this critical period. The innate immune receptor DC-SIGN functions as a sensor mediating the crosstalk between a large number of microorganisms, especially Gram-negative bacteria, and host immunity. This study aimed to investigate the role of the DC-SIGN receptor in shaping gut microbiota composition in early life.
characteristics.characteristic: description
characteristics.text: China
characteristics.characteristic: geo_loc_name
characteristics.text: Mus musculus
characteristics.ontologyTerms: http://purl.obolibrary.org/obo/NCBITaxon_10090
characteristics.characteristic: organism
characteristics.text: male
characteristics.characteristic: sex
characteristics.text: intestinal
characteristics.characteristic: tissue
characteristics.text: Model organism or animal sample from Mus musculus (house mouse)
characteristics.characteristic: title