SAMN39739099
External Id
Vigonvita Life Sciences Co.,Ltd.
INSDC center name
2025-03-01T00:52:05.650Z
INSDC first public
2025-03-01T00:52:05.650Z
INSDC last update
live
INSDC status
Model organism or animal
NCBI submission model
Model.organism.animal.1.0
NCBI submission package
3.5mo
age
2023-10
collection_date
Alzheimer's Disease (AD) is a progressive neurodegeneration which is the most common cause of dementia. Neuroinflammation drives AD disorder therefore is a promising target of immune therapy. At early stage of AD, microglia is activated into pro-inflammatory and anti-inflammatory cellular subgroups, which mediates early immune response in AD neuroinflammation. In this study, based on comparative transcriptomics analysis, we identified that the Neurodegeneration-Related Modules mediated the anti-inflammatory microglial activation. Further pharmaceutical activating and blocking assays verified that both the anti-inflammatory Neurodegeneration-Related Modules and the pro-inflammatory microglial subgroups, Interferon-Related Modules and the LPS-Related Modules, were co-regulated by several common upstream signaling pathways. This co-regulation formed a balance between the heterogeneous microglial subgroups and shaped the AD chronic neuroinflammation. This study revealed a part of immune regulation network in AD chronic neuroinflammation, which shed some light on further new drug target discovery on the neurodegenerative disease.
description
China
geo_loc_name
Mus musculus
http://purl.obolibrary.org/obo/NCBITaxon_10090
organism
male
sex
C57
strain
Brain
tissue
Model organism or animal sample from Mus musculus
title