SAMN47517796
External Id
The University of Edinburgh
INSDC center name
2025-03-21T00:00:00Z
INSDC first public
2025-03-21T18:00:06.934Z
INSDC last update
live
INSDC status
Model organism or animal
NCBI submission model
Model.organism.animal.1.0
NCBI submission package
5y
age
Cytopath Veterinary Pathology
biomaterial_provider
Domestic Shorthair
breed
Melanoma
cell_type
2024-04
collection_date
Feline diffuse iris melanoma (FDIM) is the most common primary ocular tumour in cats, with high metastatic potential. Greater intraocular invasion correlates with increased mortality. No effective therapeutics exist for metastatic disease, partly due to a lack of known molecular targets associated with aggressive tumour behaviour. Here, we define the transcriptomic landscape of FDIM in treatment-naive cats using bulk RNA sequencing on laser capture microdissection and core biopsy specimens from formalin-fixed paraffin-embedded tissue. Samples included iris melanosis (dysplastic melanocytes confined to the anterior iris; n=7), early FDIM (neoplastic melanocytes confined to the iris stroma; n=13), and late FDIM (neoplastic infiltration into the ciliary body and sclera; n=13).
description
Feline diffuse iris melanoma
disease
Early
disease_stage
United Kingdom
geo_loc_name
Felis catus
http://purl.obolibrary.org/obo/NCBITaxon_9685
organism
Tissue sample
sample_type
female
sex
Eye
tissue
Feline Diffuse Iris Melanoma and Iris Melanosis samples
title