SAMN40144647
External Id
Bened Biomedical
INSDC center name
2025-03-31T00:51:27.260Z
INSDC first public
2025-03-31T00:51:27.260Z
INSDC last update
live
INSDC status
Metagenome or environmental
NCBI submission model
Metagenome.environmental.1.0
NCBI submission package
2022-11-14
collection_date
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting over 1% of the global population. Individuals with ASD often exhibit complex behavioral conditions, including significant social difficulties and repetitive behaviors. Here, we used a well-established ASD mouse model, induced by prenatal exposure to valproic acid (VPA), to study the physiological roles of Lactiplantibacillus plantarum PS128 in vivo. Overall, we established that PS128 selectively ameliorates behavioral abnormalities in social and spatial memory in VPA-induced ASD mice. Morphological examination of dendritic architecture further revealed that PS128 facilitated the restoration of dendritic arborization and spine density in the hippocampus and prefrontal cortex of ASD mice. Notably, PS128 was crucial for restoring oxytocin levels in the paraventricular nucleus and oxytocin receptor signaling in the hippocampus. Moreover, metagenomic sequencing results shows that the PS128 alters the gut microbiota composition and increases the abundance of Bifidobacterium spp., and PS128-induced changes in Bifidobacterium abundance positively correlated with PS128-induced behavioral improvements. Together, our results show that PS128 treatment can effectively ameliorate ASD-associated behaviors and reinstate oxytocin levels in VPA-induced mice, thereby providing a promising strategy for the future development of ASD therapeutics.
description
Taiwan: Taipei
geo_loc_name
Mus musculus
host
stool
isolation_source
25.11 N 121.60 E
lat_lon
mouse gut metagenome
http://purl.obolibrary.org/obo/NCBITaxon_410661
organism
Gut metagenome isolated from mouse feces
title