SAMN47805953
External Id
Guangzhou Medical University Second Clinical College
INSDC center name
2025-04-07T00:00:00Z
INSDC first public
2025-04-07T01:01:21.813Z
INSDC last update
live
INSDC status
Model organism or animal
NCBI submission model
Model.organism.animal.1.0
NCBI submission package
Six-to-eight-week-old
age
BALB/c mice
breed
MH-S
cell_line
Alveolar macrophages
cell_type
Wuhan Procell Biotechnology Co.,Ltd.
collected_by
2023-05-10
collection_date
This dataset presents RNA sequencing data derived from the murine alveolar macrophage cell line MH-S, aiming to investigate transcriptional changes in response to lipopolysaccharide (LPS) stimulation. The study focuses on elucidating the molecular mechanisms underlying alveolar macrophage (AM) activation during acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), with an emphasis on identifying conserved inflammatory pathways and potential diagnostic biomarkers. By analyzing gene expression profiles in LPS-treated versus untreated MH-S cells, this study provides insights into the transcriptional regulators of macrophage-mediated inflammatory responses and their relevance to ALI/ARDS pathogenesis. The data contribute to a deeper understanding of the role of alveolar macrophages in pulmonary inflammation and may inform the development of targeted therapeutic strategies for ARDS.
description
China: Wuhan
geo_loc_name
Adult mice
isolate
Mus musculus
http://purl.obolibrary.org/obo/NCBITaxon_10090
organism
cell culture
sample_type
male
sex
lung
tissue
Model organism or animal sample from Mus musculus
title
the experimental group was treated with 10 ng/mL LPS (Millipore Sigma, cat#: L2630) for 72 h while the control group received an equivalent volume of complete medium.
treatment