characteristics.text: SAMN27624845
characteristics.characteristic: External Id
characteristics.text: Chinese Academy of Medical Sciences & Peking Union Medical College
characteristics.characteristic: INSDC center name
characteristics.text: 2025-05-18T00:50:19.580Z
characteristics.characteristic: INSDC first public
characteristics.text: 2025-05-18T00:50:19.580Z
characteristics.characteristic: INSDC last update
characteristics.text: live
characteristics.characteristic: INSDC status
characteristics.text: Model organism or animal
characteristics.characteristic: NCBI submission model
characteristics.text: Model.organism.animal.1.0
characteristics.characteristic: NCBI submission package
characteristics.text: 8 week
characteristics.characteristic: age
characteristics.text: R274X mutation in Phf6 is one of the most common mutation identified in both T-ALL and AML patients. However, the role of PHF6R274X in hematopoiesis remains unknown. In this study, we generated Vav1-Cre; Phf6fl-R274X/Y mouse model and investigated the role of R274X mutation on the hematopoietic system. To determine the underlying mechanism of R274X mutation in regulating HSC/HPCs, we performed RNA sequence and analyzed the expression profiles of BM LSK cells from Phf6fl-R274X/Y and Vav1-Cre; Phf6fl-R274X/Y mice.
characteristics.characteristic: description
characteristics.text: Mus musculus
characteristics.ontologyTerms: http://purl.obolibrary.org/obo/NCBITaxon_10090
characteristics.characteristic: organism
characteristics.text: male
characteristics.characteristic: sex
characteristics.text: C57BL/6J
characteristics.characteristic: strain
characteristics.text: Bone marrow
characteristics.characteristic: tissue
characteristics.text: BM LSK cell from R274X mutation mouse model
characteristics.characteristic: title