2025-10-09
ENA first public
ERC000047
ENA-CHECKLIST
EMG
INSDC center name
public
INSDC status
ERS26975105
SRA accession
SRR8865585_concoct_24
Submitter Id
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly quality
metaspades_v3.15.5
assembly software
default
binning parameters
MGnify-genomes-generation-pipeline_v1.2.0
binning software
human
broad-scale environmental context
EBI-EMG
broker name
2016-11-18
collection date
55.6
%
completeness score
CheckM2_v1.0.1
completeness software
0.06
%
contamination score
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome assembled from the metagenomic run SRR8865585 of study SRP191395.
description
intestine
environmental medium
India
geographic location (country and/or sea)
10.52000000
DD
geographic location (latitude)
76.21000000
DD
geographic location (longitude)
metagenome-assembled genome
investigation type
human gut metagenome
isolation_source
digestive system
local environmental context
human gut metagenome
metagenomic source
uncultured Eubacterium sp.
organism
Background</p><p>Recently, dysbiosis in the human gut microbiome and the potential role of several bacterial species are recognized as important factors in Colorectal cancer (CRC), which shows a high incidence in developed countries. In contrast, India is among the countries with very low incidence of CRC and it is likely that distinct gut microbiome attributable to the differences in diets and lifestyle in the Indian population, plays a role in health and disease dynamics within this population. Thus, we performed metagenomic and metabolomic association studies on faecal samples from 30 CRC patients and 30 healthy controls from two different locations in India, to provide insights into the role of the gut microbiome (bacteriome and virome) in CRC in Indian populations, in contrast with global CRC datasets.</p><p>Results</p><p>The association of CRC with Flavonifractor plautii in Indian patients profiled herein emerged as a novel finding, since this bacterium has not previously been associated with CRC. The plausible role of F. plautii appears to be linked to the degradation of beneficial anti-carcinogenic flavonoids, which was correlated with significant associations with the enzymes and modules involved in flavonoid degradation within Indian CRC samples. Thus, we hypothesise that the degradation of beneficial flavonoids might be playing a role in cancer progression within this Indian cohort. In addition, the known associations of Bacteroides and other species with CRC, as observed in previous studies were also confirmed. We also identified 20 additional microbial taxonomic markers and 33 microbial gene markers that discriminated the Indian CRC from healthy microbiomes with high accuracy based on machine learning approaches.</p><p>Conclusion</p><p>This study reveals novel insights on the CRC-associated microbiome of a unique cohort of India, the potential role of a new bacterium in CRC, and identifies cohort-specific biomarkers, which can potentially be used in non-invasive diagnosis of CRC.
project name
SAMN11355261
sample derived from
uncultured Eubacterium sp.
scientific_name
NextSeq 500
sequencing method
multi-marker approach
taxonomic identity marker
Metagenome-assembled genome: SRR8865585_concoct_24
title