characteristics.text: SAMN47926680
characteristics.characteristic: External Id
characteristics.text: Zhongshan Hospital (Xiamen), Fudan University
characteristics.characteristic: INSDC center name
characteristics.text: 2025-12-05T00:42:02.197Z
characteristics.characteristic: INSDC first public
characteristics.text: 2025-12-05T00:42:02.197Z
characteristics.characteristic: INSDC last update
characteristics.text: SRS24787773
characteristics.characteristic: INSDC secondary accession
characteristics.text: live
characteristics.characteristic: INSDC status
characteristics.text: Model organism or animal
characteristics.characteristic: NCBI submission model
characteristics.text: Model.organism.animal.1.0
characteristics.characteristic: NCBI submission package
characteristics.text: SRS24787773
characteristics.characteristic: SRA accession
characteristics.text: 10 weeks old
characteristics.characteristic: age
characteristics.text: 2023-10
characteristics.characteristic: collection_date
characteristics.text: Acetaminophen (APAP) overdose can lead to acute kidney injury (AKI), yet its molecular mechanisms remain unclear and no effective treatments are currently available. In this study, we combined transcriptomic, proteomic, and phosphoproteomic profiling of kidneys from APAP-exposed mice to explore molecular mechanism and potential therapeutic strategies. Ten-week-old male C57BL/6 mice were fasted overnight for 16 hours prior to APAP treatment. Acute kidney injury was induced by intraperitoneal injection of a high dose of APAP (300 mg/kg body weight) for 6 hours (n = 4). Control mice received an equivalent volume of PBS via intraperitoneal injection (n = 4). Kidney tissues were subsequently collected from APAP-induced kidney injury mice and PBS-injected controls.
characteristics.characteristic: description
characteristics.text: China: Shanghai
characteristics.characteristic: geo_loc_name
characteristics.text: Mus musculus
characteristics.ontologyTerms: http://purl.obolibrary.org/obo/NCBITaxon_10090
characteristics.characteristic: organism
characteristics.text: male
characteristics.characteristic: sex
characteristics.text: C57BL/6
characteristics.characteristic: strain
characteristics.text: kidney
characteristics.characteristic: tissue
characteristics.text: Kidney tissues from male wild type C57BL/6 mice
characteristics.characteristic: title