characteristics.text: SAMN39583613
characteristics.characteristic: External Id
characteristics.text: Sichuan university
characteristics.characteristic: INSDC center name
characteristics.text: 2025-12-31T00:51:13.707Z
characteristics.characteristic: INSDC first public
characteristics.text: 2025-12-31T00:51:13.707Z
characteristics.characteristic: INSDC last update
characteristics.text: live
characteristics.characteristic: INSDC status
characteristics.text: Model organism or animal
characteristics.characteristic: NCBI submission model
characteristics.text: Model.organism.animal.1.0
characteristics.characteristic: NCBI submission package
characteristics.text: Adult
characteristics.characteristic: age
characteristics.text: 2020-12-04
characteristics.characteristic: collection_date
characteristics.text: Increasing evidence implicates that human microbiome can modulate the efficacy of therapeutic drugs. However, the bacteria-drug interaction modulates longevity is not largely studied. Here, through large-scale drug screen using splicing aging marker, we identified that a fluoropyrimidine derivative doxifluridine extends lifespan and healthspan in C. elegans and ameliorate the human cellular senescence. Interestingly, the effect of doxifluridine on lifespan extension dependent on bacteria strains. Combining the bacteria E. coli and nematode C. elegans model, we used four-way screen strategy to understand the interaction between doxifluridine, nutrient, microbe and host longevity. We show that bacteria ribonucleotide metabolism can modulate doxifluridine conversion to regulates host lifespan. On the other side, doxifluridine affects metabolites in bacteria such as linoleic acid and agmatine, which regulates host lifespan. These findings provide the potential role of bacteria in regulating fluoropyrimidine effect on host longevity.
characteristics.characteristic: description
characteristics.text: day3
characteristics.characteristic: dev_stage
characteristics.text: USA: Caenorhabditis Genetics Center
characteristics.characteristic: geo_loc_name
characteristics.text: Whole body
characteristics.characteristic: isolate
characteristics.text: Caenorhabditis elegans
characteristics.ontologyTerms: http://purl.obolibrary.org/obo/NCBITaxon_6239
characteristics.characteristic: organism
characteristics.text: hermaphrodite
characteristics.characteristic: sex
characteristics.text: N2
characteristics.characteristic: strain
characteristics.text: Whole body
characteristics.characteristic: tissue
characteristics.text: Model organism or animal sample from Caenorhabditis elegans
characteristics.characteristic: title