text: 2GNR565_590_VCF_v1 - 2G_TKI_non_responder_565_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


status: PUBLIC

characteristic: SRA accession

text: IR16_5185_VCF_v1 - Imatinib_responder_16_leukaemia_CD34

characteristic: description

text: Homo sapiens

characteristic: organism

text: homo sapien

characteristic: scientific name

characteristic: submission description

characteristic: submission identifier

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors

characteristic: submission title

type: has member

CML laboratory Prof Jane F Apperley

Address: 4th floor Commonwealth Building, Hammersmith

Georgios Nteliopoulos

FirstName: Georgios

LastName: Nteliopoulos


text: IR171_C_223_R_VCF_v1 - Imatinib_responder_171_control_remission

text: Homo sapiens

text: homo sapien


text: INR23_C_5320_WB_CMR_VCF_v1 - Imatinib_non_responder_23_control_remission

text: Homo sapiens

text: homo sapien


text: INR150_4439_VCF_v1 - Imatinib_non_responder_150_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNRPS_C_44.09_R_VCF_v1 - 2G_TKI_non_responder_PS_control_remission

text: Homo sapiens

text: homo sapien


text: IR2_5561_VCF_v1 - Imatinib_responder_2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR565_C_590T_VCF_v1 - 2G_TKI_non_responder_565_control_T_cells

text: Homo sapiens

text: homo sapien


text: H_6.11_VCF_v1 - Healthy_6.11

text: Homo sapiens

text: homo sapien


text: INR53_C_116_R_VCF_v1 - Imatinib_non_responder_53_control_remission

text: Homo sapiens

text: homo sapien


text: 2GR301_344_VCF_v1 - 2G_TKI_responder_301_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR17_3955_VCF_v1 - Imatinib_non_responder_17_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR762_C_784T_VCF_v1 - 2G_TKI_non_responder_762_control_T_cells

text: Homo sapiens

text: homo sapien


text: H_9.11_VCF_v1 - Healthy_9.11

text: Homo sapiens

text: homo sapien


text: H_45.10_VCF_v1 - Healthy_45.10

text: Homo sapiens

text: homo sapien


text: H_14.11_VCF_v1 - Healthy_14.11

text: Homo sapiens

text: homo sapien


text: INR3_D7_4902_7_VCF_v1 - Imatinib_non_responder_3_leukaemia_InVitro_Day7_cytokines

text: Homo sapiens

text: homo sapien


text: IR16_TL_63664_VCF_v1 - Imatinib_responder_16_leukaemia_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: IR14_C_5141_WB_CMR_VCF_v1 - Imatinib_responder_14_control_remission

text: Homo sapiens

text: homo sapien


text: 2GRJM_C_7129_T_VCF_v1 - 2G_TKI_responder_JM_control_T_cells

text: Homo sapiens

text: homo sapien


text: H_5661_VCF_v1 - Healthy_5661

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: INR14_C_3298_T_VCF_v1 - Imatinib_non_responder_14_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GNR247_C_290T_VCF_v1 - 2G_TKI_non_responder_247_control_T_cells

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: 2GR490_C_520R_VCF_v1 - 2G_TKI_responder_490_control_remission

text: Homo sapiens

text: homo sapien


text: IR14_5141_VCF_v1 - Imatinib_responder_14_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR9_TL_5337_D_VCF_v1 - Imatinib_non_responder_9_leukaemia_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: INR3_BC_4902_VCF_v1 - Imatinib_non_responder_3_leukaemia_Blast_Crisis_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: IR25_2_5042_CD34_VCF_v1 - Imatinib_responder_25_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: H_6096_VCF_v1 - Healthy_6096

text: Homo sapiens

text: homo sapien


text: 2GR121_C_183_R_VCF_v1 - 2G_TKI_responder_121_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR148_C_199_R_VCF_v1 - 2G_TKI_non_responder_148_control_remission

text: Homo sapiens

text: homo sapien


text: IR20_3852_VCF_v1 - Imatinib_responder_20_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR509_C_535R_VCF_v1 - 2G_TKI_responder_509_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR169_C_221T_VCF_v1 - 2G_TKI_non_responder_169_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR2_D7_5623_7_VCF_v1 - Imatinib_non_responder_2_leukaemia_InVitro_Day7_cytokines

text: Homo sapiens

text: homo sapien


text: INR307_351_VCF_v1 - Imatinib_non_responder_307_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR13_3958_VCF_v1 - Imatinib_non_responder_13_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR4_5300_VCF_v1 - Imatinib_responder_4_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: IR244_287_VCF_v1 - Imatinib_responder_244_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR189_240_VCF_v1 - 2G_TKI_responder_189_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: 2GR172_224_VCF_v1 - 2G_TKI_responder_172_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR118_172_VCF_v1 - Imatinib_responder_118_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: H_5417_VCF_v1 - Healthy_5417

text: Homo sapiens

text: homo sapien


text: IR171_223_VCF_v1 - Imatinib_responder_171_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR29_5057_VCF_v1 - Imatinib_responder_29_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR637_C_666R_VCF_v1 - 2G_TKI_responder_637_control_remission

text: Homo sapiens

text: homo sapien


text: 2GR622_2_647_2_VCF_v1 - 2G_TKI_responder_622_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR2_C_5561_WB_CMR_VCF_v1 - Imatinib_responder_2_control_remission

text: Homo sapiens

text: homo sapien


text: 2GR613_642_2_VCF_v1 - 2G_TKI_responder_613_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR38_C_102_R_VCF_v1 - 2G_TKI_non_responder_38_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR203_253_VCF_v1 - 2G_TKI_non_responder_203_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR8_C_4296_T_VCF_v1 - Imatinib_non_responder_8_control_T_cells

text: Homo sapiens

text: homo sapien


text: IR22_C_5063_CMR_VCF_v1 - Imatinib_responder_22_control_remission

text: Homo sapiens

text: homo sapien


text: H_5164_VCF_v1 - Healthy_5164

text: Homo sapiens

text: homo sapien


text: 2GRGR_C_32_T_VCF_v1 - 2G_TKI_responder_GR_control_T_cells

text: Homo sapiens

text: homo sapien


text: IR28_C_4997_CMR_VCF_v1 - Imatinib_responder_28_control_remission

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: INR150_MR3_5693_VCF_v1 - Imatinib_non_responder_150_MR3_CD34

text: Homo sapiens

text: homo sapien


text: INR13_C_3958_T_v1 - Imatinib_non_responder_13_control_T_cells

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: INR4_BC_6950_VCF_v1 - Imatinib_non_responder_4_leukaemia_Blast_Crisis_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: 2GNR327_371_VCF_v1 - 2G_TKI_non_responder_327_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INRRG_27.11_VCF_v1 - Imatinib_non_responder_RG_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR1_5593_VCF_v1 - Imatinib_responder_1_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR229_C_276_R_VCF_v2 - 2G_TKI_responder_229_control_remission

text: Homo sapiens

text: homo sapien


text: IR21_4419_VCF_v1 - Imatinib_responder_21_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR2_D7D_5623_7D_VCF_v1 - Imatinib_non_responder_2_leukaemia_InVitro_Day7_cytokines_dasatinib

text: Homo sapiens

text: homo sapien


text: INR17_D7_3955_VCF_v1 - Imatinib_non_responder_17_leukaemia_InVitro_Day7_cytokines

text: Homo sapiens

text: homo sapien


text: IR7_C_5236_CMR_VCF_v1 - Imatinib_responder_7_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR274_C_319T_VCF_v1 - 2G_TKI_non_responder_274_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR5_2_5853_CD34_VCF_v1 - Imatinib_non_responder_5_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR16_4980_VCF_v1 - Imatinib_non_responder_16_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR279_323_VCF_v1 - 2G_TKI_non_responder_279_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR3_4902_VCF_v1 - Imatinib_non_responder_3_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: IR27_C_5086_CMR_VCF_v1 - Imatinib_responder_27_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR327_C_371T_VCF_v1 - 2G_TKI_non_responder_327_control_T_cells

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: 2GR622_C_647T_VCF_v1 - 2G_TKI_responder_622_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR140_2_192_CD34_VCF_v1 - Imatinib_non_responder_140_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR30_MR3_6147_VCF_v1 - Imatinib_non_responder_30_MR3_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR263_309_VCF_v1 - 2G_TKI_non_responder_263_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR177_234_VCF_v1 - 2G_TKI_responder_177_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR279_C_323T_VCF_v1 - 2G_TKI_non_responder_279_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR140_C_192_R_VCF_v1 - Imatinib_non_responder_140_control_remission

text: Homo sapiens

text: homo sapien


text: INR8_C_4296_WB_CMR_VCF_v1 - Imatinib_non_responder_8_control_remission

text: Homo sapiens

text: homo sapien


text: INR9_BC_5337_VCF_v1 - Imatinib_non_responder_9_leukaemia_Blast_Crisis_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: INR6_TL_73423_VCF_v1 - Imatinib_non_responder_6_leukaemia_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: 2GNR148_199_Sample_7_VCF_v1 - 2G_TKI_non_responder_148_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IRSB_C_28.10_R_VCF_v1 - Imatinib_responder_SB_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR227_274_VCF_v1 - 2G_TKI_non_responder_227_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNRPS_44.09_VCF_v1 - 2G_TKI_non_responder_PS_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: INR16_C_4980_T_VCF_v1 - Imatinib_non_responder_16_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GR196_C_246_R_VCF_v1 - 2G_TKI_responder_196_control_remission

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: INR23_MR3_6246_VCF_v1 - Imatinib_non_responder_23_MR3_CD34

text: Homo sapiens

text: homo sapien


text: 2GR755_779_VCF_v1 - 2G_TKI_responder_755_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR3_D14D_4902_14D_VCF_v1 - Imatinib_non_responder_3_leukaemia_InVitro_Day14_cytokines_dasatinib

text: Homo sapiens

text: homo sapien


text: 2GR490_520_VCF_v1 - 2G_TKI_responder_490_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR17_C_3955_T_VCF_v1 - Imatinib_non_responder_17_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GR531_C_558T_VCF_v1 - 2G_TKI_responder_531_control_T_cells

text: Homo sapiens

text: homo sapien


text: IR19_4851_VCF_v1 - Imatinib_responder_19_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR269_313_VCF_v1 - 2G_TKI_responder_269_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: H_7008_VCF_v1 - Healthy_7008

text: Homo sapiens

text: homo sapien


text: INR15_C_3573_T_VCF_v1 - Imatinib_non_responder_15_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GRNGM_C_205_T_VCF_v1 - 2G_TKI_responder_NGM_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GNR524_552_VCF_v1 - 2G_TKI_non_responder_524_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR9_C_5337_T_VCF_v1 - Imatinib_non_responder_9_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR267_C_312_R_VCF_v1 - Imatinib_non_responder_267_control_remission

text: Homo sapiens

text: homo sapien


text: INR348_381_VCF_v1 - Imatinib_non_responder_348_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: 2GNR719_746_319_2_VCF_v2 - 2G_TKI_non_responder_719_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR20_MR3_5562_VCF_v1 - Imatinib_responder_20_MR3_CD34

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: INR17_C_3955_CMR_VCF_v1 - Imatinib_non_responder_17_control_remission

text: Homo sapiens

text: homo sapien


text: 2GNR227_C_274T_VCF_v1 - 2G_TKI_non_responder_227_control_T_cells

text: Homo sapiens

text: homo sapien


text: IR181_229_VCF_v1_ - Imatinib_responder_181_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR305_C_350_R_VCF_v2 - Imatinib_responder_305_control_remission

text: Homo sapiens

text: homo sapien


text: IR13_C_4957_R_VCF_v2 - Imatinib_responder_13_control_remission

text: Homo sapiens

text: homo sapien


text: H_16.11_VCF_v1 - Healthy_16.11

text: Homo sapiens

text: homo sapien


text: INR53_116_VCF_v1 - Imatinib_non_responder_53_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR2_5623_VCF_v1 - Imatinib_non_responder_2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR7_2_6144_CD34_VCF_v1 - Imatinib_non_responder_7_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR115_178_Sample_3_VCF_v1 - 2G_TKI_responder_115_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR33_92_VCF_v2 - 2G_TKI_non_responder_33_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR26_C_4960_CMR_VCF_v1 - Imatinib_responder_26_control_remission

text: Homo sapiens

text: homo sapien


text: INR4_C_6950_T_VCF_v1 - Imatinib_non_responder_4_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR16_TL_61306_VCF_v1 - Imatinib_non_responder_16_leukaemia_Total_Leukocytes

text: Homo sapiens

text: homo sapien


text: INR3_D14I_4902_14I_VCF_v1 - Imatinib_non_responder_3_leukaemia_InVitro_Day14_cytokines_imatinib

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: IRKP_C_17.12_T_VCF_v1 - Imatinib_responder_KP_control_T_cells

text: Homo sapiens

text: homo sapien


text: IR19_MR3_5861_VCF_v1 - Imatinib_responder_19_MR3_CD34

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: IR28_4997_VCF_v1 - Imatinib_responder_28_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR7_C_6144_CMR_VCF_v1 - Imatinib_non_responder_7_control_remission

text: Homo sapiens

text: homo sapien


text: 2GR115_C_178_R_VCF_v1 - 2G_TKI_responder_115_control_remission

text: Homo sapiens

text: homo sapien


text: IR14_MR3_5749_VCF_v1 - Imatinib_responder_14_MR3_CD34

text: Homo sapiens

text: homo sapien


text: 2GR698_724_VCF_v1 - 2G_TKI_responder_698_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR17_D14D_3955_14D_VCF_v1 - Imatinib_non_responder_17_leukaemia_InVitro_Day14_cytokines_dasatinib

text: Homo sapiens

text: homo sapien


text: IR118_C_172_R_VCF_v1 - Imatinib_responder_118_control_remission

text: Homo sapiens

text: homo sapien


text: INR31_4618_VCF_v1 - Imatinib_non_responder_31_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR22_5063_VCF_v1 - Imatinib_responder_22_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR12_C_5080_CMR_VCF_v1 - Imatinib_responder_12_control_remission

text: Homo sapiens

text: homo sapien


text: INR2_C_5623_T_VCF_v1 - Imatinib_non_responder_2_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR2_D7I_5623_7I_VCF_v1 - Imatinib_non_responder_2_leukaemia_InVitro_Day7_cytokines_imatinib

text: Homo sapiens

text: homo sapien


text: 2GRTW_23.11_VCF_v1 - 2G_TKI_responder_TW_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR5_C_5853_T_VCF_v1 - Imatinib_non_responder_5_control_T_cells

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: 2GR131_189_Sample_6_VCF_v1 - 2G_TKI_responder_131_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR17_D14I_3955_14I_VCF_v1 - Imatinib_non_responder_17_leukaemia_InVitro_Day14_cytokines_imatinib

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: 2GNR328_369_VCF_v1 - 2G_TKI_non_responder_328_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GRCB_29.09_VCF_v1 - 2G_TKI_responder_CB_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR38_102_Sample_1_VCF_v1 - 2G_TKI_non_responder_38_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR6_C_5887_T_VCF_v1 - Imatinib_non_responder_6_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GNR295_338_VCF_v1 - 2G_TKI_non_responder_295_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR3_C_4902_T_VCF_v1 - Imatinib_non_responder_3_control_T_cells

text: Homo sapiens

text: homo sapien


text: 2GR131_C_189_R_VCF_v1 - 2G_TKI_responder_131_control_remission

text: Homo sapiens

text: homo sapien


text: IR2_MR3_6022_VCF_v1 - Imatinib_responder_2_MR3_CD34

text: Homo sapiens

text: homo sapien


text: 2GRJM_7129_VCF_v1 - 2G_TKI_responder_JM_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR524_C_552T_VCF_v1 - 2G_TKI_non_responder_524_control_T_cells

text: Homo sapiens

text: homo sapien


text: IR21_C_4419_CMR_VCF_v1 - Imatinib_responder_21_control_remission

text: Homo sapiens

text: homo sapien


text: H_13.10_VCF_v1 - Healthy_13.10

text: Homo sapiens

text: homo sapien


text: IR16_MR3_5665_VCF_v1 - Imatinib_responder_16_MR3_CD34

text: Homo sapiens

text: homo sapien


text: IR13_4957_VCF_v1 - Imatinib_responder_13_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IRSB_28.10_VCF_v1 - Imatinib_responder_SB_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: 2GNR263_C_309T_VCF_v1 - 2G_TKI_non_responder_263_control_T_cells

text: Homo sapiens

text: homo sapien


text: INR3_D7D_4902_7D_VCF_v1 - Imatinib_non_responder_3_leukaemia_InVitro_Day7_cytokines_dasatinib

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: 2GRSB_723_VCF_v1 - 2G_TKI_responder_SB_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR6_5887_VCF_v1 - Imatinib_non_responder_6_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GRIMC_6603_VCF_v1 - 2G_TKI_responder_IMC_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR17_D7I_3955_7I_VCF_v1 - Imatinib_non_responder_17_leukaemia_InVitro_Day7_cytokines_imatinib

text: Homo sapiens

text: homo sapien


text: IR181_2_229_CD34_VCF_v1 - Imatinib_responder_181_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GR176_C_227_R_VCF_v1 - 2G_TKI_responder_176_control_remission

text: Homo sapiens

text: homo sapien


text: 2GR116_179_Sample_5_VCF_v1 - 2G_TKI_responder_116_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR12_5080_VCF_v1 - Imatinib_responder_12_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR150_C_4439_WB_CMR_VCF_v1 - Imatinib_non_responder_150_control_remission

text: Homo sapiens

text: homo sapien


text: 2GR153_204_Sample_8_VCF_v1 - 2G_TKI_responder_153_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR237_282_VCF_v1 - Imatinib_non_responder_237_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: IR26_2_4960_CD34_VCF_v1 - Imatinib_responder_26_r2_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR120_181_Sample_4_VCF_v1 - 2G_TKI_non_responder_120_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: 2GNR642_668_VCF_v1 - 2G_TKI_non_responder_642_leukaemia_CD34

text: Homo sapiens

text: homo sapien

text: To investigate the potential of genetic variants in epigenetic modifiers as biomarkers at diagnosis of chronic myeloid leukaemia (CML), we used Ion Torrent next-generation sequencing of 71 candidate genes for predicting response to tyrosine kinase-inhibitors and probability of disease progression. 124 subjects with newly-diagnosed chronic-phase CML began with imatinib (n=62) or second-generation tyrosine kinase-inhibitors (n=62) and were classified as responders or non-responders based on the BCRABL1 transcript levels within the first year and the European LeukemiaNet criteria for failure. Somatic variants affecting 21 genes (e.g. ASXL1, IKZF1, DNMT3A, CREBBP) were detected in 30% of subjects, most of whom were non-responders (41% non-responders, 18% responders to imatinib, 38% non-responders, 25% responders to second-generation tyrosine kinase-inhibitors). The presence of variants predicted the rate of achieving a major molecular response, event-free survival, progression-free survival and chronic-myeloid-leukaemia-related survival in the imatinib but not the second-generation tyrosine kinase-inhibitors cohort. Rare germline variants had no prognostic significance irrespective of treatment while some pre-leukaemia variants suggest a multi-step development of chronic myeloid leukaemia. Our data suggest that identification of somatic variants at diagnosis facilitates stratification into imatinib responders/non responders, thereby allowing earlier use of second-generation tyrosine kinase-inhibitors, which, in turn, may overcome the negative impact of such variants on disease progression.


text: 2GRCOC_4.15_VCF_v1 - 2G_TKI_responder_COC_leukaemia_CD34

text: Homo sapiens

text: homo sapien


text: INR2_D14_5623_14_VCF_v1 - Imatinib_non_responder_2_leukaemia_InVitro_Day14_cytokines

text: Homo sapiens

text: homo sapien

text: Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second generation tyrosine kinase inhibitors


text: rice

characteristic: common name

text: Genomic DNA_87

text: Oryza sativa

text: Oryza sativaL.

text: We initiated the project to identify new QTL regulating the salt tolerance in rice. We carried out linkage mapping using 148 recombinant inbred lines derived from IR29 and Pokkali. The extracted genomic DNA was subjected to genotyping with single-nucleotide polymorphism (SNP) markers using an Affymetrix Axiom Rice 56k SNP Genotyping Array.The manuscript related to the project is Identification of new QTL for salt tolerance from rice variety Pokkali.

Rice Molecular Breeding

Address: No.12 Zhongguancun South St.,Haidian District, Beijing, P.R.China 100081

Tianxiao Chen

FirstName: Tianxiao

LastName: Chen


text: rice

text: Genomic DNA_147

text: Oryza sativa

text: Oryza sativaL.

text: Identification of new QTL for salt tolerance from rice variety Pokkali


text: rice

text: Genomic DNA_70

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_108

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_69

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_99

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_125

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_39

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_17

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_31

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_23

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_146

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_61

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_78

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_123

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_107

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_62

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_86

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_1

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_115

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_16

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_44

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_48

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_33

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_65

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_80

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_9

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_4

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_145

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_19

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_137

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_73

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_47

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_114

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_58

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_30

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_120

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_93

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_144

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_128

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_106

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_3

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_18

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_41

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_97

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_10

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_32

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_71

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_136

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_56

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_88

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_112

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_113

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_40

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_72

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_2

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_26

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_82

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_28

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_96

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_79

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_104

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_135

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_143

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_67

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_118

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_68

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_51

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_75

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_36

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_20

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_6

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_111

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_90

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_11

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_83

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_141

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_49

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_98

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_127

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_35

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_5

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_134

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_148

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_103

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_74

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_66

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_38

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_50

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_133

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_102

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_109

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_77

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_140

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_45

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_46

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_29

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_91

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_60

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_15

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_53

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_13

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_8

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_85

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_76

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_84

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_132

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_124

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_131

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_7

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_37

text: Oryza sativa

text: Oryza sativaL.


text: rice

text: Genomic DNA_117

text: Oryza sativa

text: Oryza sativaL.


text: HS46XX_1 - Triphalangeal thumb-polysyndactyly syndrome (TPT-PS), double outlet right ventricle, pulmonic stenosis, microphthalmia, coloboma of optic disc, 46 XX&10;

text: 2 months

characteristic: dev stage

text: Russia

characteristic: geographic location (country and/or sea)

text: Homo sapiens

text: Homo sapien

text: Female

characteristic: sex

text: In this study we report on a rare neonatal case of triphalangeal thumb-polysyndactyly syndrome (TPT-PS) combined with a severe congenital heart disease, namely double outlet right ventricle (DORV), and microphthalmia with optic disc coloboma. High-resolution array-CGH revealed a ~ 299 kb microduplication of 7q36.3 locus encompassing a long-range sonic hedgehog (SHH) regulatory sequence (ZRS).

text: Array-CGH analysis of a patient with triphalangeal thumb-polysyndactyly syndrome combined with a complex congenital heart defect and optic disc coloboma

text: Whole blood

characteristic: tissue type

Laboratory of Molecular Cardiology

Address: Akkuratova, 2, 197341, Saint-Petersburg, Russia

Anna Kostareva

FirstName: Anna

LastName: Kostareva

Anna Zlotina

LastName: Zlotina


text: Samplecattle67 - Iraqi native cattle breed67

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: This project aims to explore the genetic diversity and signature selection for environmental adaptive traits in two native Iraqi cattle breeds (Jenoubi and Rustaqi), cattle population at the crossroad of the taurine and indicine cattle domestication centers, at genome-wide level.

text: Genome analysis reveals genetic admixture and signature of selection for productivity and environmental traits in Iraqi cattle

Frozen Ark Lab

Address: Life Sciences School - University of Nottingham

AKIL ALSHAWI

FirstName: AKIL

LastName: ALSHAWI


text: Samplecattle84 - Iraqi native cattle breed84

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle72 - Iraqi native cattle breed72

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle11 - Iraqi native cattle breed11

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle17 - Iraqi native cattle breed17

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle60 - Iraqi native cattle breed60

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle55 - Iraqi native cattle breed55

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle54 - Iraqi native cattle breed54

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle34 - Iraqi native cattle breed34

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle30 - Iraqi native cattle breed30

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle10 - Iraqi native cattle breed10

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle21 - Iraqi native cattle breed21

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle38 - Iraqi native cattle breed38

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle44 - Iraqi native cattle breed44

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle26 - Iraqi native cattle breed26

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle93 - Iraqi native cattle breed93

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle66 - Iraqi native cattle breed66

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: This project aims to explore the genetic diversity and signature selection for environmental adaptive traits in two native Iraqi cattle breeds (Jenoubi and Rustaqi), cattle population at the crossroad of the taurine and indicine cattle domestication centers, at genome-wide level.


text: Samplecattle95 - Iraqi native cattle breed95

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: Genome analysis reveals genetic admixture and signature of selection for productivity and environmental traits in Iraqi cattle


text: Samplecattle14 - Iraqi native cattle breed14

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle19 - Iraqi native cattle breed19

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle29 - Iraqi native cattle breed29

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle37 - Iraqi native cattle breed37

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle8 - Iraqi native cattle breed8

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle53 - Iraqi native cattle breed53

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle33 - Iraqi native cattle breed33

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle65 - Iraqi native cattle breed65

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle80 - Iraqi native cattle breed80

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle1 - Iraqi native cattle breed1

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle82 - Iraqi native cattle breed82

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle45 - Iraqi native cattle breed45

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle32 - Iraqi native cattle breed32

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle87 - Iraqi native cattle breed87

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle22 - Iraqi native cattle breed22

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: This project aims to explore the genetic diversity and signature selection for environmental adaptive traits in two native Iraqi cattle breeds (Jenoubi and Rustaqi), cattle population at the crossroad of the taurine and indicine cattle domestication centers, at genome-wide level.


text: Samplecattle28 - Iraqi native cattle breed28

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: Genome analysis reveals genetic admixture and signature of selection for productivity and environmental traits in Iraqi cattle


text: Samplecattle79 - Iraqi native cattle breed79

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle69 - Iraqi native cattle breed69

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle74 - Iraqi native cattle breed74

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle57 - Iraqi native cattle breed57

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle94 - Iraqi native cattle breed94

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle92 - Iraqi native cattle breed92

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle77 - Iraqi native cattle breed77

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle64 - Iraqi native cattle breed64

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle16 - Iraqi native cattle breed16

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle78 - Iraqi native cattle breed78

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle2 - Iraqi native cattle breed2

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle83 - Iraqi native cattle breed83

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle47 - Iraqi native cattle breed47

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle18 - Iraqi native cattle breed18

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle76 - Iraqi native cattle breed76

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: This project aims to explore the genetic diversity and signature selection for environmental adaptive traits in two native Iraqi cattle breeds (Jenoubi and Rustaqi), cattle population at the crossroad of the taurine and indicine cattle domestication centers, at genome-wide level.


text: Samplecattle20 - Iraqi native cattle breed20

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus

text: Genome analysis reveals genetic admixture and signature of selection for productivity and environmental traits in Iraqi cattle


text: Samplecattle13 - Iraqi native cattle breed13

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle41 - Iraqi native cattle breed41

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle86 - Iraqi native cattle breed86

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle48 - Iraqi native cattle breed48

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle85 - Iraqi native cattle breed85

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle12 - Iraqi native cattle breed12

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle50 - Iraqi native cattle breed50

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle24 - Iraqi native cattle breed24

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle71 - Iraqi native cattle breed71

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle25 - Iraqi native cattle breed25

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle40 - Iraqi native cattle breed40

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: Samplecattle62 - Iraqi native cattle breed62

text: Bos indicus x Bos taurus

text: Bos taurus X Bos indicus


text: common bean

text: PH047_Mangiatutto - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: Analyses of Genotyping by Sequencing in common bean landraces

text: GBS Phaseolus vulgaris

text: leaf

Name: Institute of Biosciences and Bioresources

Address: Via Amendola 165/A, 70126 BARI, Italy

Gabriella Sonnante

FirstName: Gabriella

LastName: Sonnante


text: common bean

text: PH20_Corno di capra - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH7210_Fagioli paesani - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH5_Verdolino - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH31_Maruchedda - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH24_Locale di Accettura - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH2201_Fasule - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH4_Zolfino - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH4603_Ciammarruccoli - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH2_Villata - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH9_Tondino - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH17_Saluggia - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH8601_Fagiuline - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH13_Badda nero - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH4602_Piattella - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH15_San Michele - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH26_Mangiatutto Sx015 - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH1_billò - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH18_Gradoli - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH12_Tabacchino - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH3106_Cannellino - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH046_Mangiatutto - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH045_Fagiolino rosso - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH19_Vaianelli - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH10_Riso - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH11_Ciuoto - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH8003_Fagiolo napoletano - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH044_Monti Dauni - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH21_Monaco - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH22_Carrubara - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH32_Riso giallo - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH8_Cannellino - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH6_Poverello di Rotonda - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: common bean

text: PH3_Faeto - common bean

text: Phaseolus vulgaris

text: Phaseolus vulgaris L.

text: GBS Phaseolus vulgaris

text: leaf


text: Asiatic mouflon

text: Mouflon 8

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

characteristic: strain

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC

Name: genetics and breeding of sheep laboratory

Address: 2 Yuanmingyuan West Road， Beijing 100193，People´s Republic of China

Caihong Wei

FirstName: Caihong

LastName: Wei


text: Asiatic mouflon

text: Mouflon 18

text: Ovis aries

text: Ovis orientalis

text: Female

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 7

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 16

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 1

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 17

text: Ovis aries

text: Ovis orientalis

text: Female

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 12

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 19

text: Ovis aries

text: Ovis orientalis

text: Female

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 4

text: Ovis aries

text: Ovis orientalis

text: Female

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 13

text: Ovis aries

text: Ovis orientalis

text: Female

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 5

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 11

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 15

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 6

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Asiatic mouflon

text: Mouflon 10

text: Ovis aries

text: Ovis orientalis

text: Male

text: Mouflon

text: Whole genome resequencing 289 sheep

text: Sheep requencing in CAAC


text: Homo sapiens

text: Homo Sapien

text: Male

text: We examined a sample of 4,778 individuals (1,929 GSD cases and 2,849 controls) including two European cohorts from Germany (n = 3,702) and one admixed Latin American cohort from Chile (n = 1,076). We detected 4,336 large and rare CNVs events (size > 100 kb, frequency < 1%). CNV burden analysis revealed a significant association of CNVs with GSD, with the strongest effect observed in men with CNVs overlapping lipid metabolism genes.

text: Copy number variation (CNV) analysis in Gallstones disease (GSD)

Cologne Center for Genomics

Address: Weyertal 115, 50931 Köln, Germany

UNAB · Center for Biomedical Research

Address: Caracas 1000, Capital District, Venezuela

Eduardo Pérez-Palma

FirstName: Eduardo

LastName: Pérez-Palma

Giancarlo De Ferrari

FirstName: Giancarlo

LastName: De Ferrari


text: Homo sapiens

text: Homo Sapien

text: Female


characteristic: derived from

text: Mutant with Alkali spreading value, higher amylose content, higher starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.004G163700. New allele named: sbeIIb-2773-2. Missense Variant. Impact: Moderate. Codon change c.512G>A. Amino Acid Change p.G171E.

text: Sorghum bicolor

text: Sorghum bicolor bicolor

text: Sorghum EMS mutants exhibit the alkali spreading value, show varying amylose content, thermal properties and paste viscosity profiles

text: Sorghum EMS mutants exhibit ASV and special starch quality traits

Name: Tuinstra:Purdue University

Address: 915 West State Street, West Lafayette 47907, IN, USA

Stefanie Griebel

FirstName: Stefanie

LastName: Griebel


text: Mutant with Alkali spreading value, lower starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.010G093400. New allele named: ssIIa-4308-2.Missense and Splice Region Variant. Impact: Moderate. Codon change c.1180G>A. Amino Acid Change p.E394K.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Mutant with Alkali spreading value, higher amylose content, higher starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.004G163700. New allele named: sbeIIb-3568-6. Splice Donor and Intron Variant. Impact: High. Codon change c.2328+1G>A.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Mutant with Alkali spreading value, higher amylose content, higher starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.004G163700. New allele named: sbeIIb-3403-5. Missense Variant. Impact: Moderate. Codon change c.1593G>A. Amino Acid Change p.M531I.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Mutant with Alkali spreading value, lower starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.010G093400. New allele named: ssIIa-3920-1. Missense Variant. Impact: Moderate. Codon change c.1222G>A. Amino Acid Change p.D408N.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Mutant with Alkali spreading value, higher amylose content, higher starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.004G163700. New allele named: sbeIIb-5890-7. Splice Donor and Intron Variant. Impact: High. Codon change c.825+1G>A.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Mutant with Alkali spreading value, higher amylose content, higher starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.004G163700. New allele named: sbeIIb-2703-1. Stop gained. Impact: High. Codon change c.2053C>T. Amino Acid Change p.Q685*.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Mutant with Alkali spreading value, higher amylose content, higher starch gelatinization temperature, lower paste viscosity profile than Tx623 - SNP mutation in Sobic.004G163700. New allele named: sbeIIb-3194-3. Missense Variant. Impact: Moderate. Codon change c.1345C>T. Amino Acid Change p.R449C.

text: Sorghum bicolor

text: Sorghum bicolor bicolor


text: Thinhorn sheep tissue sample

text: Ovis dalli dalli

text: Ovis dalli

text: Using a cross species application of domestic sheep SNP array to study the genetic basis of a fitness related trait in a wild sheep species

text: Heritability of horn size in thinhorn sheep

Coltman Lab

Address: 116 St & 85 Ave, Edmonton, AB T6G 2R3

David Coltman

FirstName: David

LastName: Coltman

Zijian Sim

FirstName: Zijian

LastName: Sim


text: Long grained Rice

text: indica

characteristic: cultivar

text: Whole genome resequencing At354 - A salinity tolerant rice variety

text: Sri Lanka

text: Oryza sativa Indica Group

text: Oryza sativa indica

text: mapping the At 354 and Bg 352 rice varieties to Nipponbare rice genome (Os-Nipponbare-Reference-IRGSP-1.0) and to R498 rice genome (R498.Genome.version1)

text: QTL map based candidate gene discovery for salt tolerance in rice

Biotechnology laboratory

Address: Department of Biotechnology, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Kuliyapitiya, Sri Lanka.

Nisha Kottearachchi

FirstName: Nisha

LastName: Kottearachchi


text: Long grained Rice

text: indica

text: Whole genome resequencing Bg352 - A salinity susceptible rice variety

text: Sri Lanka

text: Oryza sativa Indica Group

text: Oryza sativa indica


text: progeny

text: Triticum aestivum

text: Triticum aestivum L.

text: High-density genetic map including FISH markers

text: Integrating the Physical and Genetic Map of Bread Wheat Facilitates the Detection of Chromosomal Rearrangements

Triticeae Research Institute

Address: Wenjiang, Sichuan, 611130, P.R. China

Zhao Laibin

FirstName: Zhao

LastName: Laibin


text: leaf

characteristic: cell type

text: Lina Qiu

characteristic: collected by

text: Wheat

text: 7D49 - The leaf of wheat material 7D49

text: China

text: Triticum aestivum

text: Triticum aestivum (2506129)

text: Wheat leaf rust resistance gene LrLC10 is highly effective to leaf rust, we re-sequenced the parental lines (Liaochun10 and 7D49) to discover the variations (SNPs and indel) on the candidate region of LrLC10 and convert them to markers to fine map the gene. It started in 2017 and is based at wheat genetic and genome center.

text: Cloning of wheat leaf rust resistance gene LrLC10

China agricultural university

Address: China Agricultural University Beijing 100193, China

Qiu Lina

FirstName: Qiu

LastName: Lina


characteristic: SRA accession

text: leaf

text: Lina Qiu

text: Wheat

text: Liaochun10 - The leaf of wheat cultivar Liaochun10

text: China

text: Triticum aestivum

text: Triticum aestivum (2506129)


L Group

text: Qin Wan

text: goose

text: Low bodyweight group

characteristic: description

text: China

text: Anser cygnoides

text: Anser anser

text: male

text: Using molecular marker-assisted selection, genetic molecular markers related to growth performance of goose buns. First, simplified genomic sequencing (RAD-sequencing) technology was used to screen SNPs with significant differences in allele frequencies between high and low growth performance groups, and the correlation between these SNPs and goose body weight was further analyzed through population verification. Based on this, the genes of SNPs were cloned. And study gene function. SNPs significantly related to growth performance were used as molecular markers in actual breeding of geese. The SNP from this project was originally reported in the 3-prime direction (C/T) (VCF - G/A 5-prime).

text: Jiangsu Major Agricultural New Variety Creation Project

Name: College of Animal Science and Technology, Nanjing Agricultural University

Address: No.1, Weigang Road, Nanjing, China

Wang Qin

FirstName: Wang

LastName: Qin


H Group

text: Qin Wan

text: goose

text: High bodyweight group

text: China

text: Anser cygnoides

characteristic: organism

text: Anser anser

text: male


HEBV

text: Shigang Yu

text: goose

text: High estimated breeding value group

text: China

text: Anser cygnoides

text: Anser anser

characteristic: scientific name

text: Female

text: Using molecular marker-assisted selection, genetic molecular markers related to Laying performance of goose.

text: Jiangsu Agriculture Science and Technology Innovation Fund


LEBV

text: Shigang Yu

text: goose

text: How estimated breeding value group

text: China

text: Anser cygnoides

text: Anser anser

text: Female

characteristic: submission description


text: Human

text: Iso 68 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien

text: We generated 3D tumour organoids from colorectal cancer patients and tested their responses to inhibitors of Tankyrase (TNKSi) which are known to modulate Wnt signalling. Complex 3D models provide a challenging platform for the quantitative analysis of drug responses of therapies that have differential effects on tumour cell subpopulations. We demonstrated that morphometric analyses can capture subtle alterations in organoid responses to Wnt inhibitors that are consistent with activity against a cancer stem cell subpopulation, highlighting the value of phenotypic readouts as a quantitative method to assess drug-induced effects in a relevant preclinical model.

characteristic: submission identifier

text: 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

School of Biosciences

Address: Biomedical Sciences Building, Museum Avenue, Cardiff, CF10 3AX, UK

Wales Gene Park

Address: Sir Geraint Evans Cardiovascular Research Building, Heath Park, Cardiff, CF14 4ED

Marc Naven

FirstName: Marc

LastName: Naven

Trevor Dale

FirstName: Trevor

LastName: Dale


text: Human

text: Iso 34 matched control - Matched germline blood sample for Iso 34

text: Homo sapiens

text: Homo Sapien

characteristic: submission title


text: Human

characteristic: common name

text: Iso 72 matched control - Matched germline blood sample for Iso 72

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 48 matched control - Matched germline blood sample for Iso 48

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 49 matched control - Matched germline blood sample for Iso 49

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 68 matched control - Matched germline blood sample for Iso 68

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 72 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 48 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 38 matched control - Matched germline blood sample for Iso 38

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 75 matched control - Matched germline blood sample for Iso 75

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 78 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 75 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 78 matched control - Matched germline blood sample for Iso 78

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 49 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 57 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 34 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 57 matched control - Matched germline blood sample for Iso 57

text: Homo sapiens

text: Homo Sapien

text: We generated 3D tumour organoids from colorectal cancer patients and tested their responses to inhibitors of Tankyrase (TNKSi) which are known to modulate Wnt signalling. Complex 3D models provide a challenging platform for the quantitative analysis of drug responses of therapies that have differential effects on tumour cell subpopulations. We demonstrated that morphometric analyses can capture subtle alterations in organoid responses to Wnt inhibitors that are consistent with activity against a cancer stem cell subpopulation, highlighting the value of phenotypic readouts as a quantitative method to assess drug-induced effects in a relevant preclinical model.


text: Human

text: Iso 38 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien

text: 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors


text: Human

text: Iso 50 - Colorectal cancer organoid line derived from patient tumour samples

text: Homo sapiens

text: Homo Sapien


text: Human

text: Iso 50 matched control - Matched germline blood sample for Iso 50

text: Homo sapiens

text: Homo Sapien


text: Biyun - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze

text: 191 tea resources were sequenced , and the whole genome association analysis was carried out to obtain SNP related to tea taste metabolites.

text: Genome-wide Association Analysis Identifies Molecular Markers Associated with Tea Flavor-related Metabolites

Name: Guangdong Key Laboratory of Tea Plant Resources Innovation &Utilization

Address: No. 6, Dafeng Road, Wushan, Tianhe District, Guangzhou City, Guangdong Province

Fang Kaixing

FirstName: Fang

LastName: Kaixing


text: Hongyan NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hunandonghuzao - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dongya NO.11 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongyan NO.6 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Wulinghong - Bred tea varieties

text: Camellia sinensis var. assamica

text: Camellia sinensis var. assamica (Masters) Kitamura


text: Lechangbaimao NO.3 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Youxuan NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dongya NO.7 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongyan NO.8 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lingyun NO.7 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Shanqieye - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Zimudan - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dababaimao NO.6 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Kenniya NO.1 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Ankuangzhong - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Guibeidaye NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Huangmeigui - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dongya NO.8 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Huangyeshuixian - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Baiyun 595 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lechangbaimao NO.2 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Baimudan - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: C14 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Youxuan NO.17 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Banshanyuancha NO.21 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yinghong NO.11 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Dancong NO.22 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dayeqilan NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.20 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Longmenzhong NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Jinyaoshi - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Bantianyao - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Banshanyuancha NO.20 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.10 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Lingyun NO.4 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Dongya NO.9 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dababaimao NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Xinxuan NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Qingxin NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Longmenzhong NO.9 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Kenniya NO.7 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: D1 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Lingyun NO.16 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Xinxuan NO.10 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Youxuan NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.13 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Hepingxiaoye NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yinghong NO.5 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Mingke NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongyan NO.9 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Bianhong NO.21 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yingchaqimen NO.6 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Bairuixiang - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Milanxiang - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: D4 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Junshanyinzhen NO.1 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Gelujiya NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Helanxiang - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Zijuan - Bred tea varieties

text: Camellia sinensis var. assamica


text: Hunanxiangbolv - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Wuyedancong - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Guangzhouxiaoyebaixin NO.3 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Youyicha - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Fuyou NO.1 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yinghong NO.1 - Bred tea varieties

text: Camellia sinensis var. assamica


text: Huangyezao - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Puningxiaoye NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Mingke NO.3 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze

text: 191 tea resources were sequenced , and the whole genome association analysis was carried out to obtain SNP related to tea taste metabolites.


text: D29 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze

text: Genome-wide Association Analysis Identifies Molecular Markers Associated with Tea Flavor-related Metabolites


text: Chunlan - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Xinxuan NO.9 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.15 - New Strain of tea tree

text: Camellia sinensis var. assamica

text: Camellia sinensis var. assamica (Masters) Kitamura


text: Youxuan NO.7 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Banshanyuancha NO.10 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yingshuang - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Guangzhouxiaoyebaixin NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Xinxuan NO.12 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Xinxuan NO.7 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongyan NO.7 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Shizubaimao NO.7 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Ruiming - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yundadanlv - Bred tea varieties

text: Camellia sinensis var. assamica


text: Xinxuan NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Qingfeng - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dancong NO.27 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Fuyun NO.6 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Ruixiang - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lingyun NO.11 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Huiyangxiaoye NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Fengqing NO.1 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Guangnongdayeqingxin NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Youyexiang - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: A6 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Maoyecha 544 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Dongya NO.6 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Shizubaimao NO.6 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Dancong NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Xinxuan NO.3 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yabacha - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dancong NO.3 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lechangbaimao NO.5 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Dongya NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lechangbaimao NO.10 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Benshan NO.1 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lechangbaimao NO.14 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Hongye NO.1 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Hongyan NO.12 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Shangpocha - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.17 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Pukeng NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongyan NO.3 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lingyun NO.22 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.16 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Bijiacha NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Kenniya NO.11 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: A35 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Kenniya NO.12 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Danxia NO.8 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Guangningdayeqingxin NO.5 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Kenniya NO.27 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Hongye NO.24 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Guangningdayeqingxin NO.3 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hongye NO.22 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Guihong NO.4 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Guanyin NO.18 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Baxian 43 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Hunanzhuyeqi - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Yingchaqimen NO.1 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Aifeng - Bred tea varieties

text: Camellia sinensis var. assamica


text: Huangqi - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Longmenzhong NO.6 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dongya NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Banshanyuancha NO.12 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Zaochunhao - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze

text: 191 tea resources were sequenced , and the whole genome association analysis was carried out to obtain SNP related to tea taste metabolites.


text: Dababaimao NO.1 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang

text: Genome-wide Association Analysis Identifies Molecular Markers Associated with Tea Flavor-related Metabolites


text: Xinxuan NO.5 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Fuyou NO.2 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: B22 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Jiangxishangmeizhouzhong - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lechangbaimao NO.4 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Xinxuan NO.4 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Gaozhouhongya NO.2 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Qianmei 809 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Chunxuan - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Dangui - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lingyun NO.18 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Duanjiebaihao - Bred tea varieties

text: Camellia sinensis var. assamica

text: Camellia sinensis var. assamica (Masters) Kitamura


text: A26 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Lingyun NO.3 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Yundadanzhu NO.7 - New Strain of tea tree

text: Camellia sinensis var. assamica


text: Jilongkan - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Banshanyuancha NO.8 - New Strain of tea tree

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Mingfeng - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Guihong NO.3 - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze


text: Lingyun NO.6 - New Strain of tea tree

text: Camellia sinensis var. pubilimba

text: Camellia sinensis var. pubilimba Chang


text: Maoyecha 437 - New Strain of tea tree

text: Camellia ptilophylla

text: Camellia ptilophylla Chang


text: Chaoyang - Bred tea varieties

text: Camellia sinensis var. sinensis

text: Camellia sinensis (L.) O. Kuntze