title: NimbleGen_C.novyi-NT
status: Public on Nov 20 2006
contact.city: Baltimore
contact.first: Xin
contact.last: Huang
contact.email: xhuang8@jhmi.edu
contact.state: MD
contact.address: 1650 Orleans Street, CRB I, Room 520
contact.department: Oncology
contact.country: USA
contact.institute: Johns Hopkins University
organism: Clostridium novyi NT
manufacture_protocol: NimbleGen selects 5 optimal probes for each of the 2325 predicted coding sequences of Clostridium novyi-NT using a proprietary probe screening system developed exclusively for the MAS platform. Probe sets are selected which uniquely represent the genomic target or gene transcripts of interest, and which are predicted to have excellent hybridization characteristics. Our predictive software is based on a combination of NimbleGen's innovative Tm-balanced probe selection coupled with heuristic and AI predictive methods derived from a growing volume of experimental data.
  NimbleGen manufactures custom, high-density DNA arrays based on its proprietary Maskless Array Synthesizer (MAS) technology. The MAS system is a bench top, solid-state, high-density DNA array fabrication instrument comprised of a maskless light projector, a reaction chamber, a personal computer, and a DNA synthesizer. NimbleGen builds its arrays using photo-mediated synthesis chemistry with its MAS system.