title: SuperArray GEArray Q Series Human Cancer Drug Resistance & Metabolism Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The GEArray Q Series Human Cancer Drug Resistance & Metabolism Gene Array contains 96 genes involved in the body's response to chemotherapy. The genes encoding important enzymes for drug resistance (such as the P-glycoproteins), phase I metabolism (specifically the P450 family), and phase II metabolism (such as various covalent modification enzymes) are all represented on the array. (See the list below.) The expression of certain cancer-related genes also helps determine aspects of resistance, and these are also included on the array such as DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, and transcription factors. Understanding the metabolism of potential chemotherapeutic agents as well as how easily resistance can be developed against them is an important aspect of their design. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these genes involved in the metabolism of and the development of resistance to cancer drugs.
  Catalog number HS-019 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site