title: SuperArray GEArray Q Series Human PI3K-AKT Signaling Pathway Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The phosphatidylinositol-3-kinase (PI3K) and AKT (Protein Kinase B) signaling pathway regulates a variety of biological processes including survival, proliferation, cell growth, cell motility and glycogen metabolism. Abnormalities in PI3K-AKT signaling contribute to the pathogenesis of several human diseases such as diabetes and cancer. Many growth and survival factors activate PI3K family members to specifically convert one lipid signaling molecule, PIP2, into another, PI(3,4,5)P3. The phosphorylated product subsequently recruits Akt family members to the inner leaflet of the plasma membrane and stimulates their protein kinase activity. To date, many Akt effectors involved in several biological processes have been identified. For example, the Akt kinases mediate cell survival though phosphorylation and inactivation of apoptotic machinery components. Although Akt acts as the main effector for PI3K, other Akt-independent effectors also play important roles in carrying out PI3K signaling. This GEArray is designed to systematically study the relative expression of genes associated with PI3K and AKT signaling in your experimental system.
  Catalog number HS-058 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site