title: HumanHap300-2 v2.0 Genotyping BeadChip
status: Public on Jul 31 2007
contact.city: Bethesda
contact.first: GEO
contact.last: admin
contact.email: geo@ncbi.nlm.nih.gov
contact.state: MD
contact.address: 9000 Rockville Pike
contact.country: USA
contact.institute: NCBI/NLM/NIH
organism: Homo sapiens
description: HumanHap300-2 v2.0 Genotyping BeadChip provides genome-wide coverage using >318,000 tag SNPs chosen from the International HapMap Project.
  
  The HumanHap300-Duo BeadChip is a two-sample format and contains:
  • >318,000 tag SNPs derived from the Phase I and II HapMap data, >42,000 of these from Phase II HapMap data.
  • A higher density of tag SNPs in regions of the genome within 10kb of a gene or in evolutionarily conserved regions.
  • Approximately 7,300 nsSNPs (non-synonymous amino-acid changing SNPs).
  • A higher density of SNPs across Major Histocompatibility Complex (MHC) regions.
  • Higher genomic coverage with fewer SNPs compared to wholegenome genotyping strategies that use randomly selected SNPs.
  • Approximate 5kb median SNP spacing, providing unprecedented resolution for detecting chromosomal aberrations.
  • The ability to analyze matched (paired) samples for LOH and DNA copy number analysis applications.
  • Over 52,000 SNPs in reported copy number variant (CNV) regions1.
manufacture_protocol: other