title: SuperArray GEArray Q Series Mouse Hypoxia Signaling Pathway Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Mus musculus
description: GEArray Q Series Mouse Hypoxia Signaling Pathway Gene Array contains 96 genes whose expression is affected by hypoxia. The wide variety of such target genes is provided in the list below. Hypoxia is defined as the insufficient supply or utilization of oxygen. Hypoxia alters gene expression through transcriptional activation and post-transcriptional mRNA stabilization mechanisms. Hypoxia activates its specific transcriptional pathway via stabilization of the hypoxia-inducible factor 1 (HIF1) and its subsequent binding to a defined hypoxia response element in the promoter of the affected genes. In additional, HIF-independent pathways are also involved in transcriptional activation by hypoxia. Hypoxia is involved in many physiological and pathophysiological processes such as erythropoiesis, ventilatory adjustment, hypoxic pulmonary vasoconstriction and hypertension, sleep apnea, vascular remodeling, angiogenesis and tumor growth, myocardial and brain ischemic/reperfusion damage. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these 96 hypoxia-regulated genes in your model system.
  Catalog number MM-032 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site