title: SuperArray GEArray Q Series Human G-Proteins & Signaling Molecules Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The GEArray Q Series Human G-Proteins &  Signaling Molecules Gene Array represents G-protein subunits and their downstream signaling and effector proteins. The heterotrimeric guanine nucleotide-binding proteins (G-proteins) relay signals from G-Protein Coupled Receptors (GPCR) to multiple downstream signaling pathways. Upon activation by GPCR ligand binding, the alpha subunit of a G-protein exchanges nucleotide and dissociates from the beta and gamma subunit complex. Key upstream regulators of specific signaling pathways recognize and bind either or both of these G-protein components. The GPCR family is the largest one in the genome that plays important roles in diverse physiological functions including immune responses, hormone function, learning and memory, embryonic development, gonadal development, and homeostasis. Based on the sequence similarity of the alpha subunits and the nature of the functions they regulate, G-protein signaling is divided into four different pathways. This GEArray is designed for studying the relative gene expression profile of 11 alpha, 3 beta and 9 gamma subunits, as well as several effectors and downstream signaling molecules in each of these G-protein pathways.
  Catalog number HS-047 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site