title: SuperArray GEArray Q Series Human Wnt Signaling Pathway Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The GEArray Q Series Human Wnt Signaling Pathway Gene Array is designed to systematically profile the expression of genes involved in and downstream of Wnt signaling. The array includes the Wnt ligands and their receptors, intracellular signaling molecules, and representative target genes. The Wnt signaling pathway plays a pivotal role in embryonic development, causes tumorigenesis when aberrantly activated, and may also be involved in angiogenesis. The Wnt family is composed of roughly 20 glycosylated extracellular signaling molecules having corresponding receptors and antagonists. Wnt signaling proceeds through at least two pathways: the better understood canonical (Wnt / beta-catenin) pathway and the more newly discovered non-canonical (Wnt / calcium) pathway. Some Wnt proteins signal through the canonical pathway only, while others can signal through both pathways. Each Wnt ligand activates a unique set of target genes that mediate a specific biological response. Therefore, this array can be used to determine the pathway activation profile of a particular Wnt family member as well as the expression of genes related to Wnt signaling. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 genes in the Wnt signaling pathway.
  Catalog number HS-043 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site