title: TESSF393

status: Public on Jul 31 2004

city: Naples

first: Massimo

last: Zollo

state: Naples

address: Via Pietro Castellino,111

department: TIGEM/ZOLLO

country: Italy

institute: TIGEM (Telethon Institute of genetics and Medicine)

description: TESS library is a collection of genes preferentially expressed in the embryonic telencephalon. cDNA clones of library TESS sequence validated, were amplified by PCR using primers that were complementary to the vector sequence. PCR products were robotically arrayed (PIXISYS) into lysine-coated slides (CMT-GAPSTM Coated Slides, Corning Microarray Technology). A total of 1026 cDNA clones were printed twice on each slides.


title: Mouse oligo array using Operon 17K set

city: Cambridge

first: Jatin

last: Misra

state: MA

country: USA

institute: MIT

organism: Mus musculus

technology: spotted oligonucleotide

description:
Spotted long oligonucleotide array on GAPS II slides from Corning.
Details regarding this particular platform are available in GPL285, this is a simplified version of the same

distribution: non-commercial

first: Ilias

last: Alevizos

first: Greg

last: Stephanopoulos


title: TESS185

technology: spotted DNA/cDNA

description: TESS library is a collection of genes preferentially expressed in the embryonic telencephalon. cDNA clones of library TESS sequence validated, were amplified by PCR using primers that were complementary to the vector sequence. PCR products were robotically arrayed (PIXISYS) into lysine-coated slides (CMT-GAPSTM Coated Slides, Corning Microarray Technology). A total of 1026 cDNA clones were printed on each slides.


title: Rat 27K cDNA array

city: Rockville

first: Norman

middle: H

last: Lee

state: MD

address: 9712 Medical Center Drive

department: Department of Mammalian Genomics

institute: The Institute for Genomic Research

organism: Rattus norvegicus

description: cDNA arrays were prepared from the TIGR Rat 26K Microarray clone set. The clone set represents 20,465 unique sequences (16,306 unique Tentative Consensus sequences plus 4,159 singleton ESTs based on the current Rat Gene Index Build 11.0; http://www.tigr.org/tdb/tgi/rgi/). Following amplification and purification, PCR amplicons were resuspended at 100-200 nM final concentration in 50% DMSO and printed onto bar-coded UltraGAPS Coated Slides (Corning, #40015.) using an Automated Microarraying System from Brooks Automation, Inc (Chelmsford, MA) equipped with a 48 pin printhead containing Stealth 3 MicroSpotting Pins (Telechem International, Inc.). Print configuration is 48 blocks in a 4 x 12 arrangement. Spot diameters are approximately 90-100 microns. Control reporters were printed in alternating blocks, and included 10 Arabidopsis gene fragments, mouse COT, human COT, salmon sperm DNA, 50% DMSO and poly dA. After printing, DNA was cross-linked to the slides by UV irradiation at 120 mJ/cm2 (Stratalinker UV Crosslinker, Stratagene) and subsequently stored at room temperature in a desiccated chamber until use.


title: TESS400-2


title: TESS039

description: TESS library is a collection of genes preferentially expressed in the embryonic telencephalon. cDNA clones of  library TESS sequence validated, were amplified by PCR using primers that were complementary to the vector sequence. PCR products were robotically arrayed (PIXISYS) into lysine-coated slides (CMT-GAPSTM Coated Slides, Corning Microarray Technology). A total of 1026 cDNA clones were printed on each slides.


title: UCSF Gladstone v.2 Oligo Array (6-2002)

status: Public on Jul 28 2004

city: San Francisco

first: Michael

middle: E.

last: Salazar

state: CA

address: 1550 Fourth Street, RM 545

institute: University of California, San Francisco

description:
Spotted long oligonucleotide array on glass. The library used was the Qiagen/Operon v2.0 mouse oligo library, which is composed of oligonucleotides (70mers) representing 16,443 unique mouse genes.
Keywords = spotted, long oligonucleotide

middle: E


title: Sugarcane ESTs nylon arrays I

status: Public on Jul 23 2004

city: Campinas

first: Vicente

middle: Eugenio

last: De Rosa Junior

state: SP

department: CBMEG

country: Brazil

institute: Unicamp

organism: Saccharum officinarum species complex

description: Nylon membranes containing sugarcane ESTs. Plasmid clones were used. A set of sixteen 96-well plates was spotted on two nylon filters (85 mm x 125 mm) in a 4 x 4 array configuration, with a 96 pins hand-held array pin tool.

first: VICENTE

last: de Rosa Jr

first: FABIO

middle: T

last: Nogueira

first: MARCELO

last: Menossi

first: EUGENIO

middle: C

last: Ulian

first: PAULO

last: Arruda


title: NIEHS Rat Chip v3.0

status: Public on Jul 17 2004

city: Durham

first: Rick

middle: David

last: Fannin

state: NC

address: 111 T.W. Alexander Drive

department: Office of the Director

institute: The National Institute of Environmental Health Sciences

description:
This array was developed in-house at NIEHS, and used for gene expression profiling experiments. A complete listing of the genes on this chip is available at the following Web site: http://dir.niehs.nih.gov/microarray/chips.htm
cDNA microarray chips were prepared according to DeRisi et al., 1996, Nat. Genet. 14, 457-460. The spotted cDNAs were derived from a collection of sequence-verified clones that covered the 3` end of the gene and ranged in size from 500 to 2000 base pairs (Research Genetics). M13 primers were used to amplify insert cDNAs from purified plasmid DNA in a 100 5l polymerase chain reaction (PCR) mixture. A sample of the PCR products (10 microliters) was separated on 2% agarose gels to ensure quality of the amplifications. The remaining PCR products were purified by ethanol precipitation, resuspended in ArrayIt buffer (Telechem, San Jose CA) and spotted onto poly-L-lysine-coated glass slides using a modified, robotic DNA arrayer (Beecher Instruments, Bethesda MD).
-- taken largely verbatim from Hamadeh et al., Toxicological Sciences 67, 219-231 (2002)

Keywords = Toxicogenomics
Keywords = National Center for Toxicogenomics
Keywords = NIEHS


title: Ontario Cancer Institute full-genome S. cerevisiae ORF array (Version: GP_Y6.5k1_SDDC2_v1.1)

city: Toronto

first: Andy

middle: L

last: Bognar

state: Ontario

address: 1 King's College Circle

department: Medical Genetics and Biology

country: Canada

institute: University of Toronto

organism: Saccharomyces cerevisiae

description: Full-genome S. cerevisiae ORF microarray spotted with all 6240 ORFs plus control spots totals to 6.4k by the Microarray Centre at the Ontario Cancer Institute, University Health Network of the University of Toronto.

first: Jonathan

middle: D

last: Lalich


title: BCBC Mouse PancChip 2.0 Array

status: Public on Jul 11 2004

city: Palo Alto

first: Wen-Jun

last: Shen

address: 3801 Miranda Avenue

department: Medicine

institute: Stanford University

description:
Mouse PancChip 2.0 array from EPConDB.  EPConDB is a resource of the Beta Cell Biology Consortium and contains information on genes expressed in cells of the pancreas identified by dbEST libraries from pancreatic tissues including the 12 mouse and 7 human libraries generated by the Endocrine Pancreas Consortium.

See below website for more information about the array used.

first: Yu

last: Liang

first: Jenny

last: Wang

first: Kenji

last: Harada

first: Shailja

last: Patel

first: Jun-ichi

last: Osuga

first: Shun

last: Ishibashi

first: Fredric

middle: B

last: Kraemer


title: Ontario Cancer Institute full-genome S. cerevisiae ORF array (Version: GP_Y6.4k1_v2)


title: NIAID Mycobacterium tuberculosis microarray Mtbb

city: Bethesda

first: Michael

last: Wilson

address: 50 South Drive, Room 5509

department: Division of Intramural Research

organism: Mycobacterium tuberculosis

description:
Printing by NIAID / Microarray Research Facility
Surface type: non-adsorptive, epoxy-coated glass
Attachment: covalent
Array description: The custom microarrays are manufactured by the Microarray Research Facility of the National Institute of Allergy and Infectious Diseases (NIH/NIAID). Microarrays are printed with an Omnigrid robotic arrayer by Genomic Solutions (http://www.genomicsolutions.com ) that is fitted with a printhead and 32 SMP3 print tips from Telechem (http://www.arrayit.com ). The M. tuberculosis microarray (Mtbb) probe set is based on 70mer oligonucleotides from Qiagen's Tuberculosis Genome Oligo Set Version 1.0 ( http://oligos.qiagen.com/arrays/omad.php ).  Oligonucleotide probes are distributed into 384-well polypropylene plates (Genetix, 384 micro array) and dissolved in print buffer (150mM sodium phosphate, pH 8.5, 4% sodium sulfate, 0.0001% N-lauryl sarcosyl) to a normalized 25 micromolar concentration.  The Mtbb microarray spot densities are 270 microns (center-to-center).  The microarrays are printed on MWG Epoxy Slides (MWG Biotech Inc., # 1150-000000) or PowerMatrix Slides (Full Moon Biosystems, # PXP-M) and treated by a method that is an adaptation of the manufacturer's instructions to allow higher throughput processing.


title: NIAID Group A Streptococcus

status: Public on Jul 14 2004

city: Hamilton

first: Frank

middle: R.

last: DeLeo

state: MT

address: 903 South 4th Street

organism: Streptococcus pyogenes

description:
Printing: NIAID/RML/LHBP
Surface type: Gamma Amino Propyl Silane (Corning GAPS) coated glass
Attachment: covalent, (UV-treated)
Array description: The custom microarrays are manufactured by the Laboratory of Human Bacterial Pathogenesis (LHBP), Rocky Mountain Laboratories (RML), of the National Institute of Allergy and Infectious Diseases, National Institutes of  Health (NIAID/NIH).
Microarrays are printed with a Bio-Rad VersArray ChipWriter Pro robotic arrayer that is fitted with a 48 pin printhead and 32 SMP3 print tips from Telechem (http://www.arrayit.com). The GAS microarray probe set is based on ~500 bp PCR products for each open reading frame (ORF) from GAS strain SF370 (AE004092) and unique ORFs from GAS strains MGAS 8232 (AE009949), and MGAS 315 (AE014074).  The probes are distributed into 384-well polypropylene plates (Whatman polyfiltronics) and dissolved in 3X SSC print buffer at a normalized 25 micromolar concentration. The microarray spot densities are 200 micrometers (center-to-center rows) and 240 micrometers (center-to-center columns). The microarrays are printed on Corning GAPS coated slides and post-processed according to the procedures recommended by the manufacturer.


title: Yeast Hitachi 77

city: Paris

first: Frederic

last: Devaux

country: France

institute: Ecole Normale Superieure

description:
Yeast microarrays supplied by Hitachi.
PCR products. Batch number 77.
Keywords = yeast
Keywords = transcriptome

distribution: custom-commercial


title: SGDB Yeast

description:
Yeast S. cerevisiae microarrays from the SGDB (Ecole Normale Superieure, Paris, France). Yeast ORFs are deposited in duplicate (double genome). Probes are oligonucleotides (40mers) from the Yeast oligoset distributed by MWG Biotech.
Keywords = yeast
Keywords = transcriptome

first: Veronique

last: Tanty

first: Corinne

last: Blugeon

first: Stephane

last: Le Crom

first: Claude

last: Jacq


title: Hughes Lab Saccharomyces cerevisiae cDNA ORF array

status: Public on Jul 01 2004

first: Timothy

middle: Richard

last: Hughes

state: ON

address: 112 College St.

department: Banting and Best Department of Medical Research

description:
Spotted long oligonucleotide array on glass
Full-genome cDNA array of all S. cerevisiae ORFs made by Hughes Lab
This set includes 6307 oligonucleotides, mostly 70-mers, designed by Operon.
Keywords = spotted
Keywords = oligonucleotide
Keywords = yeast
Keywords = Saccharomyces cerevisiae

middle: R


title: ISB_yeast_ORF_4866-4895

status: Public on Jun 28 2004

city: Seattle

first: Bruz

last: Marzolf

state: WA

institute: Institute for Systems Biology

description: Spotted oligo array of the 6308 70-mer probes purchased from QIAGEN/Operon.  Printed by the Microarray Facility at the Institute for Systems Biology

first: Jeffrey

middle: A

last: Ranish

first: Steven

last: Hahn

last: Lu

first: Eugene

last: Yi

first: Xiao-jun

last: Li

first: Jimmy

last: Eng

first: Ruedi

last: Aebersold


title: Saccharomyces cerevisiae ncRNA array

description:
oligonucleotide array on glass
array covering all known ncRNA in S. cerevisiae made by Agilent
contains 21939 oligonucleotides of average length 18.4, concatenated to 60
Keywords = oligonucleotide, yeast, Saccharomyces cerevisiae, ncRNA


title: RG1-208P5

status: Public on May 18 2004

first: Don

last: Ganem

organism: Homo sapiens

description:
Spotted cDNA array on glass
This platform includes ~20,000 human EST elements (Research Genetics) and ~200 PCR amplified ORF fragments from Human herpesvirus 8 (NC_003408).
Keywords = KSHV
Keywords = host shutoff
Keywords = vGPCR

first: Britt

last: Glaunsinger

first: David

last: Wang

first: Donald


title: STv3_MMCC

status: Public on May 10 2004

city: Irvine

first: Michael

last: McClelland

address: 132 Med Surge I

department: Microbiology & Molecular Genetics

institute: University of California, Irvine

organism: Salmonella enterica

description: Custom made Salmonella array

first: Steffen

last: Porwollik

first: Jonathan

middle: G

last: Frye

first: Colleen

last: Eckhardt

first: Felisa

last: Blackmer


title: VT1_JAX1_Oligo_02

status: Public on Jun 26 2004

city: Bar Harbor

first: Janet

last: Pereira

state: ME

address: 600 Main St.

department: Gene Expression Service

institute: The Jackson Laboratory

description: This oligo array interrogates nearly 22,000 unique mouse genes from the Compugen Mouse Release 2.0 oligonucleotide platform.


title: RG1-208P6


title: GF400 Resgen

status: Public on Jun 15 2004

city: Toulouse

first: Guillaume

last: Charriere

description: Nylon cDNA microarrays membranes spotted  and commercialized by Research Genetics (Invitrogen). This membranes contains about 5000 mouse genes and ESTs.

first: Emmanuelle

last: Arnaud

first: Louis

last: Casteilla


title: UHN Microarray Centre - Single Spot Human 19K4

status: Public on Jun 04 2004

city: Ottawa

first: Felix

middle: M.

last: Mesak

address: 503 Smyth Rd. 3rd Floor

department: Centre for Cancer Therapeutics

institute: Ottawa Regional Cancer Centre

description:
cDNA microarrays are printed on CMT-GAPS slides (Corning Inc.) using high precision robotics. Contains 19200 characterized and unknown human ESTs. This platform is the single spotted 19k array version 4. The cDNA microarray can be purchased at University Health Network (UHN) Microarray Centre, Ontario Cancer Institute (OCI), Toronto, Canada (http://www.microarrays.ca).
Keywords = cDNA microarray
Keywords = ESTs

middle: M

first: Cheng

last: Ng


title: G. max and P. sojae custom array

status: Public on Apr 29 2004

city: London

first: Mark

last: Gijzen

address: 1391 Sandford St

department: Agriculture & AgriFood Canada

institute: SCPFRC London

organism:
Glycine max
Phytophthora sojae

description:
3,927 soybean cDNA's from root Gm-r1021, cotyledon Gm-r1030, mixed Gm-r1070, seed coat SC and infection site HA.
969 Phytophthora cDNA's from zoospore ZO, mycelia MY and infection site HA
Keywords = soybean
Keywords = phytophthora infection

first: Pat

last: Moy

first: Dinah

last: Qutob

first: B

middle: P

last: Chapman

first: Ian

last: Atkinson


title: Print214_NHGRI

status: Public on Jun 17 2004

city: New York

first: Sally

last: Amundson

state: NY

department: Center for Radiological Research

institute: Columbia University

description:
This is a cDNA microarray spotted on glass prepared from PCR amplification of clones from the IMAGE Consortium cDNA library.  The PCR and printing protocols, as well as more information about the IMAGE clone library, are detailed on the web site http://research.nhgri.nih.gov/microarray/main.html
and have also been published in "Current Protocols in Human Genetics".  RNA extraction and labeling protocols used are published (PMID 14970650) as are the data extraction and processing methods (PMID 12217912).

last: Bittner

first: Paul

middle: S

last: Meltzer

first: Jeffrey

last: Trent

first: Albert

middle: J

last: Fornace


title: A111

status: Public on May 16 2004

city: Menlo Park

first: Gregory

last: Fisk

address: 230 Constitution Dr.

institute: Geron Corp.

description: Custom microarrays containing  763 50-mer oligonucleotides spotted in duplicate were prepared by MWG Biotech (High Point, NC).  Briefly, 752 genes involved in heart, liver, pancreas and neural development as well as genes identified as differentially expressed by EST counts were selected.  In addition, 11 control oligos were included. Through a bioinformatics process developed by MWG Biotech, gene-specific, Tm normalized oligos were designed.  Amine modified oligos were synthesized and spotted onto epoxy coated slides (MWG Biotech).

first: Ralph

last: Brandenberger

first: Henry

last: Wei

last: Zhang

first: Shirley

last: Lei

first: Jaji

last: Murage

first: Yan

last: Li

first: Chunhui

last: Xu

first: Rixun

last: Fang

first: Karl

last: Guegler

first: Mahendra

last: Rao

first: Ramumkar

last: Mandalam

first: Jane

last: Lebkowski

first: Lawrence

middle: W

last: Stanton


title: SuperArray GEArray Q series Human cAMP/Ca2+ PathwayFinder Gene Array

status: Public on Apr 09 2004

city: Frederick

first: SuperArray

last: Bioscience Corporation

address: Suite 101, 7320 Executive Way

institute: Technical Support

description:
GEArray Q series Human cAMP/Ca2+ PathwayFinder Gene Array contains 96 target genes that are responsive to cAMP or Ca2+. cAMP and Ca2+ are two universal second messengers that mediate a staggering array of different functions, through signaling within the cytoplasm and to the nucleus for activation of gene expression. Both cAMP and Ca2+ signaling converge on CREB, activation of which subsequently affects target genes containing the CRE enhancer element in their promoters. Besides CRE, Ca2+ signaling can also activate target genes with an SRE enhancer element or other, as yet undefined Ca2+ responsive element in their promoters. In addition, cAMP and Ca2+ signals generated from each specific stimuli can vary on concentration, spatial location and duration and can trigger very different transcriptional responses. Therefore, a specific profile of target gene expression can be derived for each stimuli and the profile can be used as a fingerprint to screen for agonists and antagonists for its stimuli. cAMP/Ca2+ PathwayFinder GEArray Q contains three groups of Ca2+ responsive target genes: 1) target genes with SRE; 2) target genes with CRE; 3) target genes with undefined elements. This gene array is designed for you to distinguish cAMP signaling (only genes in group 1 are activated), and Ca2+ signaling (genes in group 1, 2, 3 are activated), and to study transcription response associated with cAMP and Ca2+ signaling. Through a simple side-by-side hybridization, you can determine simultaneously the change of the expression profile of these 96 genes involved in cAMP/Ca2+  signaling by using your experimental and control RNA samples, arrays and reagents provided in the kit.
Catalog number HS-028 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php

distribution: commercial

manufacture_protocol: see manufacturer's web site


title: SuperArray GEArray Q Series Mouse Signal Transduction PathwayFinder Gene Array

description:
GEArray Q Series Mouse Signal Transduction PathwayFinder Gene Array contains 96 marker genes associated with 18 signal transduction pathways. Through a simple side-by-side hybridization, using your RNA samples and the arrays and reagents provided, you can determine whether any of the 18 signal transduction pathways may be involved in your experimental system. You can then use our other pathway-specific GEArrays to further analyze changes in gene expression in the pathway pertinent to your research. For example, if you find expression differences in the NFkB marker genes, you can then use our GEArray Q Series NFkB Pathway Gene Array to study this pathway in depth. The signal transduction pathways and their marker genes are listed below.
Catalog number MM-008 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: Mm27K

status: Public on Apr 28 2004

first: Leslie

last: Rogler

address: 1300 Morris Park Ave

department: Liver Research Center/ Department of Medicine

institute: Albert Einstein College of Medicine

description:
These cDNA    were obtained from the Albert Einstein College of Medicine
Functional Genomics Facility (http://www.aecom.yu.edu/cancer/new/cores/microarray/admin.htm). 27400 sequence verified mouse clones were
spotted in each array. The clones are from 3 sources: the 8968 clones in
the MGEM1.0 plates from Incyte, the 14208 clones in the MNCI-V1 plates from NCI (see http://lgsun.grc.nia.nih.gov/cDNA/15k.html), and the 4224 clones in the MIMP-V1 plates originally from Research Genetics.


title: SuperArray GEArray Q Series Human Hypoxia Signaling Pathway Gene Array

description:
GEArray Q Series Human Hypoxia Signaling Pathway Gene Array contains 96 genes whose expression is affected by hypoxia. The wide variety of such target genes is provided in the list below. Hypoxia is defined as the insufficient supply or utilization of oxygen. Hypoxia alters gene expression through transcriptional activation and post-transcriptional mRNA stabilization mechanisms. Hypoxia activates its specific transcriptional pathway via stabilization of the hypoxia-inducible factor 1 (HIF1) and its subsequent binding to a defined hypoxia response element in the promoter of the affected genes. In additional, HIF-independent pathways are also involved in transcriptional activation by hypoxia. Hypoxia is involved in many physiological and pathophysiological processes such as erythropoiesis, ventilatory adjustment, hypoxic pulmonary vasoconstriction and hypertension, sleep apnea, vascular remodeling, angiogenesis and tumor growth, myocardial and brain ischemic/reperfusion damage. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these 96 hypoxia-regulated genes in your model system.
Catalog number HS-032 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse cAMP/Ca2+ PathwayFinder Gene Array

description:
GEArray Q series Mouse cAMP/Ca2+ PathwayFinder Gene Array contains 96 target genes that are responsive to cAMP or Ca2+. cAMP and Ca2+ are two universal second messengers that mediate a staggering array of different functions, through signaling within the cytoplasm and to the nucleus for activation of gene expression. Both cAMP and Ca2+ signaling converge on CREB, activation of which subsequently affects target genes containing the CRE enhancer element in their promoters. Besides CRE, Ca2+ signaling can also activate target genes with an SRE enhancer element or other, as yet undefined Ca2+ responsive element in their promoters. In addition, cAMP and Ca2+ signals generated from each specific stimuli can vary on concentration, spatial location and duration and can trigger very different transcriptional responses. Therefore, a specific profile of target gene expression can be derived for each stimuli and the profile can be used as a fingerprint to screen for agonists and antagonists for its stimuli. cAMP/Ca2+ PathwayFinder GEArray Q contains three groups of Ca2+ responsive target genes: 1) target genes with SRE; 2) target genes with CRE; 3) target genes with undefined elements. This GEArray is designed for you to distinguish cAMP signaling (only genes in group 1 are activated), and Ca2+ signaling (genes in group 1, 2, 3 are activated), and to study transcription response associated with cAMP and Ca2+ signaling. Through a simple side-by-side hybridization, you can determine simultaneously the change of the expression profile of these 96 genes involved in cAMP/Ca2+ signaling by using your experimental and control RNA samples, arrays and reagents provided in the kit.
Catalog number MM-028 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: Berkeley_DGC_print_1

status: Public on May 01 2004

city: Kansas City

first: Marco

last: Blanchette

state: MO

institute: Stowers Institute for Medical Research

organism: Drosophila melanogaster

description: PCR fragment from the DGC1.0 EST collection

first: Emmanuel

last: Labourier

first: Donald

last: Rio


title: SuperArray GEArray Q Series Mouse Hypoxia Signaling Pathway Gene Array

description:
GEArray Q Series Mouse Hypoxia Signaling Pathway Gene Array contains 96 genes whose expression is affected by hypoxia. The wide variety of such target genes is provided in the list below. Hypoxia is defined as the insufficient supply or utilization of oxygen. Hypoxia alters gene expression through transcriptional activation and post-transcriptional mRNA stabilization mechanisms. Hypoxia activates its specific transcriptional pathway via stabilization of the hypoxia-inducible factor 1 (HIF1) and its subsequent binding to a defined hypoxia response element in the promoter of the affected genes. In additional, HIF-independent pathways are also involved in transcriptional activation by hypoxia. Hypoxia is involved in many physiological and pathophysiological processes such as erythropoiesis, ventilatory adjustment, hypoxic pulmonary vasoconstriction and hypertension, sleep apnea, vascular remodeling, angiogenesis and tumor growth, myocardial and brain ischemic/reperfusion damage. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these 96 hypoxia-regulated genes in your model system.
Catalog number MM-032 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: Dog heart cDNA

status: Public on Jun 06 2004

first: Rouet

last: Philippe

state: FRANCE

address: 37 Allées Jules Guesde

institute: Louis Bugnard

organism: Canis lupus familiaris

description:
DNA microarray from substractive cDNA library of dog heart
Keywords = Heart dog obesity hypertension

first: Pierre

last: Philip-Couderc


title: SuperArray GEArray Q Series Human G Protein-Coupled Receptor Gene Array I

description:
The GEArray Q Series Human G Protein-Coupled Receptor Gene Array I contains 96 genes encoding G Protein-Coupled Receptors (GPCR). The GPCR family includes at least 450 members, many of which are pharmacologically important proteins. These receptors and the biological pathways they regulate are the targets of hundreds of pharmaceuticals including antihistamines, neuroleptics, antidepressants, and antihypertensives. The GPCR family members are cell-surface receptors containing seven membrane-spanning regions. They transduce extracellular signals from their ligands (such as hormones, neurotransmitters, chemokines, autocrine and paracrine factors) by activating heterotrimeric guanine nucleotide-binding proteins (G proteins), which route the signals through several distinct intracellular signaling pathways. These signaling pathways then activate a response specific to each GPCR involved in diverse biological processes such as specific immune responses, learning and memory, embryonic development, gonadal development, or organismal homeostasis. This GEArray contains 96 of the more popular GPCR genes and is designed to measure their relative expression levels simultaneously.
Catalog number HS-035 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: STv4_MMCC

first: Michael

last: McClelland

description: Custom made Salmonella array

first: Steffen

last: Porwollik

first: Jonathan

last: Frye

first: Colleen

last: Eckhardt

first: Scott

last: Jackson

first: Felisa

last: Blackmer


title: SuperArray GEArray Q Series Human G Protein-Coupled Receptor Gene Array II

description:
The GEArray Q Series Human G Protein-Coupled Receptor Gene Array II contains 96 genes encoding G Protein-Coupled Receptors (GPCR) and some of their regulators. The GPCR family includes at least 450 members, many of which are pharmacologically important proteins. These receptors and the biological pathways they regulate are the targets of hundreds of pharmaceuticals including antihistamines, neuroleptics, antidepressants, and antihypertensives. The GPCR family members are cell-surface receptors containing seven membrane-spanning regions. They transduce extracellular signals from their ligands (such as hormones, neurotransmitters, chemokines, autocrine and paracrine factors) by activating heterotrimeric guanine nucleotide-binding proteins (G proteins), which route the signals through several distinct intracellular signaling pathways. These signaling pathways then activate a response specific to each GPCR involved in diverse biological processes such as specific immune responses, learning and memory, embryonic development, gonadal development, or organismal homeostasis. This GEArray contains more than 70 of the more popular GPCR genes and more than 20 genes representing regulators of GPCR activity. The array is specifically designed to measure all of their relative expression levels simultaneously.
Catalog number HS-046 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Signal Transduction PathwayFinder Gene Array

description:
GEArray Q Series Human Signal Transduction PathwayFinder Gene Array contains 96 marker genes associated with 18 signal transduction pathways. Through a simple side-by-side hybridization, using your RNA samples and the arrays and reagents provided, you can determine whether any of the 18 signal transduction pathways may be involved in your experimental system. You can then use our other pathway-specific GEArrays to further analyze changes in gene expression in the pathway pertinent to your research. For example, if you find expression differences in the NFkB marker genes, you can then use our GEArray Q Series NFkB Pathway Gene Array to study this pathway in depth. The signal transduction pathways and their marker genes are listed below.
Catalog number HS-008 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse G Protein-coupled Receptors Signaling PathwayFinder Gene Array

description:
GEArray Q series Mouse G Protein-coupled Receptors Signaling PathwayFinder Gene Array is designed to help you to navigating through the pathways activated by G protein-coupled receptors (GPCR). GPCRs constitute the largest family of cell surface molecules involved in signal transmission. These receptors are activated by a wide variety of ligands, including peptide and non-peptide neurotransmitters, hormones, growth factors, odorant molecules and light. These receptors are the target of >50% of the current therapeutic agents on the market, including more than a quarter of the 100 top-selling drugs. Recent studies demonstrated that cellular response mediated by GPCR results from the functional integration of an intricate network of intracellular signaling pathways. The intracellular signaling pathways activated by GPCR signaling include cAMP/PKA pathway, Ca2+/PKC pathway, Ca2+/NFAT pathway, PLC pathway, Protein tyrosine kinase pathway, PKC/MEK pathway, p43/p44MAP pathway, p38 MAP pathway, PI-3 Kinase pathway, NO-cGMP pathway, Rho pathway, NFkB pathway and Jak/Stat pathway. In this GEArray, we have included membrane receptors and transcriptional target genes as pathway representative markers. These genes were reported to response to GPCR signaling through the indicated pathway. Through pathway specific inhibitor studies, it is shown that multiple pathways can regulate the same target gene simultaneously or at different phases. Therefore, this GEArray not only provides you a tool to identify the activated pathways, but also allow you to generate a pathway activation profile at each time point of stimulation for your specific GPCR. The GPCR-specific pathway activation profile can then be used for screening of ligands, agonists and antagonists.
Catalog number MM-025 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Human G Protein-coupled Receptors Signaling PathwayFinder Gene Array

description:
GEArray Q series Human G Protein-coupled Receptors Signaling PathwayFinder Gene Array is designed to help you to navigating through the pathways activated by G protein-coupled receptors (GPCR). GPCRs constitute the largest family of cell surface molecules involved in signal transmission. These receptors are activated by a wide variety of ligands, including peptide and non-peptide neurotransmitters, hormones, growth factors, odorant molecules and light. These receptors are the target of >50% of the current therapeutic agents on the market, including more than a quarter of the 100 top-selling drugs. Recent studies demonstrated that cellular response mediated by GPCR results from the functional integration of an intricate network of intracellular signaling pathways. The intracellular signaling pathways activated by GPCR signaling include cAMP/PKA pathway, Ca2+/PKC pathway, Ca2+/NFAT pathway, PLC pathway, Protein tyrosine kinase pathway, PKC/MEK pathway, p43/p44MAP pathway, p38 MAP pathway, PI-3 Kinase pathway, NO-cGMP pathway, Rho pathway, NFkB pathway and Jak/Stat pathway. In this GEArray, we have included membrane receptors and transcriptional target genes as pathway representative markers. These genes were reported to response to GPCR signaling through the indicated pathway. Through pathway specific inhibitor studies, it is shown that multiple pathways can regulate the same target gene simultaneously or at different phases. Therefore, this GEArray not only provides you a tool to identify the activated pathways, but also allow you to generate a pathway activation profile at each time point of stimulation for your specific GPCR. The GPCR-specific pathway activation profile can then be used for screening of ligands, agonists and antagonists.
Catalog number HS-025 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human G-Proteins & Signaling Molecules Gene Array

description:
The GEArray Q Series Human G-Proteins &  Signaling Molecules Gene Array represents G-protein subunits and their downstream signaling and effector proteins. The heterotrimeric guanine nucleotide-binding proteins (G-proteins) relay signals from G-Protein Coupled Receptors (GPCR) to multiple downstream signaling pathways. Upon activation by GPCR ligand binding, the alpha subunit of a G-protein exchanges nucleotide and dissociates from the beta and gamma subunit complex. Key upstream regulators of specific signaling pathways recognize and bind either or both of these G-protein components. The GPCR family is the largest one in the genome that plays important roles in diverse physiological functions including immune responses, hormone function, learning and memory, embryonic development, gonadal development, and homeostasis. Based on the sequence similarity of the alpha subunits and the nature of the functions they regulate, G-protein signaling is divided into four different pathways. This GEArray is designed for studying the relative gene expression profile of 11 alpha, 3 beta and 9 gamma subunits, as well as several effectors and downstream signaling molecules in each of these G-protein pathways.
Catalog number HS-047 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human PI3K-AKT Signaling Pathway Gene Array

description:
The phosphatidylinositol-3-kinase (PI3K) and AKT (Protein Kinase B) signaling pathway regulates a variety of biological processes including survival, proliferation, cell growth, cell motility and glycogen metabolism. Abnormalities in PI3K-AKT signaling contribute to the pathogenesis of several human diseases such as diabetes and cancer. Many growth and survival factors activate PI3K family members to specifically convert one lipid signaling molecule, PIP2, into another, PI(3,4,5)P3. The phosphorylated product subsequently recruits Akt family members to the inner leaflet of the plasma membrane and stimulates their protein kinase activity. To date, many Akt effectors involved in several biological processes have been identified. For example, the Akt kinases mediate cell survival though phosphorylation and inactivation of apoptotic machinery components. Although Akt acts as the main effector for PI3K, other Akt-independent effectors also play important roles in carrying out PI3K signaling. This GEArray is designed to systematically study the relative expression of genes associated with PI3K and AKT signaling in your experimental system.
Catalog number HS-058 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse Drug Metabolism Gene Array

description:
GEArray Q series Mouse Drug Metabolism Gene Array contains 96 genes critical in the drug metabolism process. The metabolism of drugs, toxic chemicals, hormones and micronutrients is an important topic in the fields of pharmacology, endocrinology and food science. It is often implicated in many diseases and pathophysiological processes, such as cancer, resistance to chemotherapy, intoxification, addiction and metabolic diseases. The genes encoding enzymes that are important for drug transport, phase I metabolism, and phase II metabolism are represented on the array. With a simple side-by-side hybridization experiment, using your RNA samples and our GEArray Q series Mouse Drug Metabolism Gene Array kit, you can study the expression profile of the genes involved in drug metabolism.
Catalog number MM-011 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Neurotrophin and Receptors Gene Array

description:
Each GEArray Q Series Human Neurotrophin and Receptors Gene Array kit is designed to profile the expression of 96 neurotrophic signaling molecules involved in growth, differentiation, survival, diseases, regeneration, and normal functions of the neuronal system. Six groups of genes are included in this array: neurotrophins and receptors, neuropeptides and receptors, growth factors involved in neuronal growth and differentiation, cytokines and receptors involved in neuronal signaling, signaling molecules indicative of activation of down stream pathways, and genes involved in neuronal apoptosis in response to neurotrophic factors. Through a simple side-by-side hybridization, you can determine simultaneously the expression profile of these genes in your samples, using the arrays and reagents provided.
Catalog number HS-018 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Neuroscience-1 Ion Channel & Transporter Gene Array

description:
The GEArray Q Series Human Neuroscience-1 Ion Channel & Transporter Gene Array was developed to profile expression of a panel of 96 genes encoding neuroscience-related ion channels and transporters. The genes represented on the array are listed below, grouped into six categories according to their functional and structural features. Included are calcium channels, potassium channels, sodium channels, chloride channels, and transporters. Through a simple side-by-side hybridization, you can determine the expression profile of these genes by using your experimental RNA samples and the arrays and reagents provided in the kit.
Catalog number HS-013 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Th1-Th2-Th3 Gene Array

description:
There are three different classes of CD4+ T lymphocytes, or helper T cells: Th1, Th2 and Th3. An imbalance in the relative abundance of Th1 versus Th2 cells has been associated with asthma, atopic diseases, and autoimmune diseases. All three sub-types of T-helper cells can be identified by the cytokines they express upon activation. These cytokines in turn mediate specific immune responses. For example, endotoxin, a bacterial compound, is a potent stimulator of Th1 cells. Therefore, Th1 cells secrete cytokines that predominantly activate intracellular defenses against bacteria. On the other hand, a number of intractable viruses and parasites, such as HIV, hepatitis B and C, and malaria induce cellular responses that favor the Th2 sub-type allowing virally infected cells to remain undetected by the immune system. Activated Th2 cells, also usually associated with atopic diseases, secrete cytokines that activate extracellular defense mechanisms. Th3 cells share certain characteristics common to both Th1 and Th2 cells; however, their apparently unique regulatory and functional roles have defined them as a novel sub-type. To help you determine the relative abundances of these subtypes in your cell culture population or clinical sample, the Th1-Th2-Th3 Gene Array includes the cytokine genes that are representative of Th1, Th2 and Th3 cells. The array also contains genes encoding transcriptional factors that regulate the expression of these cytokines as well as other markers of CD4+ T lymphocytes.
Catalog number MM-021 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Human Drug Metabolism Gene Array

description:
GEArray Q series Human Drug Metabolism Gene Array contains 96 genes critical in the drug metabolism process. The metabolism of drugs, toxic chemicals, hormones and micronutrients is an important topic in the fields of pharmacology, endocrinology and food science. It is often implicated in many diseases and pathophysiological processes, such as cancer, resistance to chemotherapy, intoxification, addiction, and metabolic diseases. The genes encoding enzymes that are important for drug transport, phase I metabolism, and phase II metabolism are represented on the array. With a simple side-by-side hybridization experiment, using your RNA samples and our GEArray Q series Human Drug Metabolism Gene Array kit, you can study the expression profile of the genes involved in drug metabolism.
Catalog number HS-011 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Neurotrophin and Receptors Gene Array

description:
Each GEArray Q Series Mouse Neurotrophin and Receptors Gene Array kit is designed to profile the expression of 96 neurotrophic signaling molecules involved in growth, differentiation, survival, diseases, regeneration, and normal functions of the neuronal system. Six groups of genes are included in this array: neurotrophins and receptors, neuropeptides and receptors, growth factors involved in neuronal growth and differentiation, cytokines and receptors involved in neuronal signaling, signaling molecules indicative of activation of down stream pathways, and genes involved in neuronal apoptosis in response to neurotrophic factors. Through a simple side-by-side hybridization, you can determine simultaneously the expression profile of these genes in your samples, using the arrays and reagents provided.
Catalog number MM-018 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Drug Targets for Inflammation & Immunomodulation Gene Array

description:
Inflammation and immunomodulation are two major and pharmacologically important functions of the immune response. The body responds to injury through inflammation, a complex process activated to effect repairs and defend against any invading organisms. Normally, the appropriate signals deactivate inflammation after it completes these functions; however, it can continue unchecked at low levels under certain circumstances. Uncontrolled and chronic inflammation contributes to a broad spectrum of diseases including atherosclerosis, arthritis, asthma, diabetes, cancer and neurological diseases such as Alzheimer and Parkinson diseases. To date, many drugs control inflammation and help decrease the susceptibility to these disease states by blocking key receptors, enzymes and other mediators of the process. Many targets of immunomodulation, which includes immunosuppression, tolerance and immunostimulation, have been identified and used to develop better agents to control unchecked immune responses. This GEArray contains all of the known drug targets involved in inflammation and immunomodulation. It is designed to allow you to systematically study the gene expression of these drug targets and their association with specific physiologic and pathologic conditions as well as their sensitivity and response to drugs.
Catalog number HS-048 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Insulin Signaling Pathway Gene Array

description:
GEArray Q Series Human Insulin Signaling Pathway Gene Array is designed to assess the role of insulin-responsive genes in your experimental system. Insulin mediates a wide spectrum of biological responses associated with glucose uptake, glycogen, lipid and protein synthesis, transcriptional activation, cell growth and differentiation. Dysfunctional insulin signaling results in insulin resistance that is associated with diabetes, obesity, hypertension and cardiovascular disease. The GEArray Q Series Human Insulin Signaling Pathway Gene Array includes 96 key genes that are grouped into the following categories: the PI 3-kinase pathway, targets of the PI 3-kinase pathway, the MAPK pathway, targets of the MAPK pathway, primary insulin target genes, secondary insulin target genes, target genes associated with the insulin sensitizer, PPARg, and targets of the insulin-activated transcription factor, SREBP. These functional groupings allow the researcher to conveniently identify the activation of insulin-associated pathways and to obtain a "molecular signature" under their specific experimental conditions.
Catalog number HS-030 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human NFkB Signaling Pathway Gene Array

description:
Each GEArray Q Series Human NFkB Signaling Pathway Gene Array contains 96 genes related to NFkB mediated signal transduction. The NFkB transcription factors are implicated in the regulation of viral replication, autoimmune diseases, inflammatory responses, tumorigenesis and apoptosis. With a simple side-by-side hybridization experiment by using your RNA samples and GEArray Q Series Human NFkB Signaling Pathway Gene Array kit, you can characterize the expression profile of the Rel / NFkB / IkB family, genes responsive to NFkB signaling, and other genes involved in the NFkB signal transduction pathway.
Catalog number HS-016.2 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Nitric Oxide Gene Array

description:
The GEArray Q Series Human Nitric Oxide Gene Array contains 96 genes whose expression is controlled by or involved in signaling by the second messenger nitric oxide (NO). The list of genes on this array, shown below, demonstrates the variety of targets downstream of NO. They include chemokines and cytokines, ECM and adhesion molecules, growth factors and hormones and their receptors, transcription factors and many others. NO is very reactive, short acting, and generates reactive nitrogen species (RNS) that help NO mediate its signal transduction. NO/RNS-regulated gene expression involves different mechanisms including mRNA stabilization, translation modulation, and covalent modification of proteins. Imbalances in the levels of extracellular and intracellular NO occur in many physiological and pathophysiological processes. The cellular processes regulated by NO/RNS include metabolism and endogenous defense mechanisms against a variety of stresses and diseases. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of the following NO-regulated genes.
Catalog number HS-034 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Human Interleukins and Receptors Gene Array

description:
GEArray Q series Human Interleukins and Receptors Gene Array contains 72 genes encoding interleukins and interleukin receptors. The regulation of expression of interleukins and interleukin receptors and their antagonists play fundamental roles in the development and function of immune system. Through a simple side-by-side hybridization, you can determine the expression profile of these genes by using your experimental RNA samples and the array and reagents provided in the kit.
Catalog number HS-014 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Th1-Th2-Th3 Gene Array

description:
There are three different classes of CD4+ T lymphocytes, or helper T cells: Th1, Th2 and Th3. An imbalance in the relative abundance of Th1 versus Th2 cells has been associated with asthma, atopic diseases, and autoimmune diseases. All three sub-types of T-helper cells can be identified by the cytokines they express upon activation. These cytokines in turn mediate specific immune responses. For example, endotoxin, a bacterial compound, is a potent stimulator of Th1 cells. Therefore, Th1 cells secrete cytokines that predominantly activate intracellular defenses against bacteria. On the other hand, a number of intractable viruses and parasites, such as HIV, hepatitis B and C, and malaria induce cellular responses that favor the Th2 sub-type allowing virally infected cells to remain undetected by the immune system. Activated Th2 cells, also usually associated with atopic diseases, secrete cytokines that activate extracellular defense mechanisms. Th3 cells share certain characteristics common to both Th1 and Th2 cells; however, their apparently unique regulatory and functional roles have defined them as a novel sub-type. To help you determine the relative abundances of these subtypes in your cell culture population or clinical sample, the Th1-Th2-Th3 Gene Array includes the cytokine genes that are representative of Th1, Th2 and Th3 cells. The array also contains genes encoding transcriptional factors that regulate the expression of these cytokines as well as other markers of CD4+ T lymphocytes.
Catalog number HS-021.2 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Inflammatory Cytokines & Receptors Gene Array

description:
GEArray Q Series Human Inflammatory Cytokines & Receptors Gene Array contains 96 cytokine and receptor genes associated with inflammatory response. Cytokines play an important role in mediating immune cascade reactions during the inflammatory response. Through a simple side-by-side hybridization, using your RNA samples and the arrays and reagents provided, you can study the gene expression profile of cytokines and their receptors that are involved in the inflammatory response.
Catalog number HS-015 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Extracellular Matrix & Adhesion Molecules Gene Array

description:
The GEArray Q Series Human Extracellular Matrix & Adhesion Molecules Gene Array contains 96 genes encoding proteins important for the attachment of cells to their surroundings. As seen in the list below, the array includes various types of cell adhesion molecules (such as the intregrins, IgG superfamily members, cadherins and catenins, and selectins) as well as extracellular matrix proteins, proteases (such as the matrix metalloproteinases and the serine and cysteine proteinases) and their inhibitors. These proteins play key roles in mediating cell-cell, cell-tissue and cell-extracellular matrix interactions and are involved in the normal processes of cell growth, division, differentiation, migration, as well as apoptosis. These genes are also important in many diseases and pathophysiological processes, including tumor invasion and metastasis, rheumatoid arthritis, cardiovascular disorders, wound healing, inflammation, and some central nervous diseases. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these matrix and adhesion molecules in your model system.
Catalog number HS-010 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Nitric Oxide Gene Array

description:
The GEArray Q Series Mouse Nitric Oxide Gene Array contains 96 genes whose expression is controlled by or involved in signaling by the second messenger nitric oxide (NO). The list of genes on this array, shown below, demonstrates the variety of targets downstream of NO. They include chemokines and cytokines, ECM and adhesion molecules, growth factors and hormones and their receptors, transcription factors and many others. NO is very reactive, short acting, and generates reactive nitrogen species (RNS) that help NO mediate its signal transduction. NO/RNS-regulated gene expression involves different mechanisms including mRNA stabilization, translation modulation, and covalent modification of proteins. Imbalances in the levels of extracellular and intracellular NO occur in many physiological and pathophysiological processes. The cellular processes regulated by NO/RNS include metabolism and endogenous defense mechanisms against a variety of stresses and diseases. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of the following NO-regulated genes.
Catalog number MM-034 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Neuroscience-1 Ion Channel & Transporter Gene Array

description:
The GEArray Q Series Mouse Neuroscience-1 Ion Channel & Transporter Gene Array was developed to profile expression of a panel of 96 genes encoding neuroscience-related ion channels and transporters. The genes represented on the array are listed below, grouped into six categories according to their functional and structural features. Included are calcium channels, potassium channels, sodium channels, chloride channels, and transporters. Through a simple side-by-side hybridization, you can determine simultaneously the expression profile of these genes by using your experimental RNA samples and the arrays and reagents provided in the kit.
Catalog number MM-013 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse Common Cytokine Gene Array

description:
GEArray Q Series Mouse Common Cytokines Gene Array contains 96 common mouse cytokine genes. An important aspect of immunology is the determination of cytokine expression during cell activation, proliferation, and differentiation. In addition, cytokines play important and diverse roles in the regulation of the normal immune system and development, as well as roles in many diseases and pathologies, including cancer and diabetes. Through a simple side-by-side hybridization using the Mouse Common Cytokines GEArray Q Series kit, you can determine the cytokine expression profile under your experimental conditions. The cytokine genes represented on the array are listed below, grouped according to their gene family and/or functional roles.
Catalog number MM-003 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray Nylon-on-Glass GEArray: Human Autoimmune and Inflammatory Response Gene Array

description:
The Nylon-on-Glass GEArray Human Autoimmune and Inflammatory Response Gene Array is designed to profile the expression of genes known to be involved in and important to immune responses such as autoimmunity and inflammation. It contains 360 known genes that encode adaptor proteins, cell surface receptors, cytokines and chemokines and their receptors, signal transduction proteins, transcription factors and other genes responsive to the autoimmune and inflammatory responses. Housekeeping and negative control genes are also included for background correction and normalization to generate relative gene expression profiles. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays and reagent provided in this kit, and a SuperArray probe synthesis kit (sold separately), you can simultaneously determine the expression profile of these 360 genes important to autoimmune and inflammatory responses.
Catalog number HS-602.2 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Insulin Signaling Pathway Gene Array

description:
GEArray Q Series Mouse Insulin Signaling Pathway Gene Array is designed to assess the role of insulin-responsive genes in your experimental system. Insulin mediates a wide spectrum of biological responses associated with glucose uptake, glycogen, lipid and protein synthesis, transcriptional activation, cell growth and differentiation. Dysfunctional insulin signaling results in insulin resistance that is associated with diabetes, obesity, hypertension and cardiovascular disease. The GEArray Q Series Mouse Insulin Signaling Pathway Gene Array includes 96 key genes that are grouped into the following categories: the PI 3-kinase pathway, targets of the PI 3-kinase pathway, the MAPK pathway, targets of the MAPK pathway, primary insulin target genes, secondary insulin target genes, target genes associated with the insulin sensitizer, PPARg, and targets of the insulin-activated transcription factor, SREBP. These functional groupings allow the researcher to conveniently identify the activation of insulin-associated pathways and to obtain a "molecular signature" under their specific experimental conditions.
Catalog number MM-030 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Inflammatory Cytokines & Receptors Gene Array

description:
GEArray Q Series Mouse Inflammatory Cytokines & Receptors Gene Array contains 96 cytokine and receptor genes associated with inflammatory response. Cytokines play an important role in mediating immune cascade reactions during the inflammatory response. Through a simple side-by-side hybridization using your RNA samples and the arrays and reagents provided, you can study the gene expression profile of cytokines and their receptors that are involved in the inflammatory response.
Catalog number MM-015 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Extracellular Matrix & Adhesion Molecules Gene Array

description:
GEArray Q Series Mouse Extracellular Matrix & Adhesion Molecules Gene Array contains 96 genes encoding cell adhesion and extracellular matrix proteins. These proteins play key roles in mediating cell-cell, cell-tissue and cell-extracellular matrix interactions and are involved in cell growth, division, differentiation, migration, as well as apoptosis. These genes are also important in many diseases and pathophysiological processes, including tumor invasion and metastasis, rheumatoid arthritis, cardiovascular disorders, wound healing, inflammation, and some central nervous diseases. With a simple side-by-side hybridization experiment, using your RNA samples and the arrays and reagents provided in this kit, you can easily study the expression profile of these genes in your experimental system.
Catalog number MM-010 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse Interleukins and Receptors Gene Array

description:
GEArray Q series Mouse Interleukins and Receptors Gene Array contains 55 genes encoding interleukins and interleukin receptors. The regulation of expression of interleukins and interleukin receptors and their antagonists play fundamental roles in the development and function of immune system. Through a simple side-by-side hybridization, you can determine the expression profile of these genes by using your experimental RNA samples and the array and reagents provided in the kit.
Catalog number MM-014 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Cardiovascular Disease Gene Array II: Atherosclerosis

description:
The GEArray Q Series Human Cardiovascular Disease Gene Array II is designed to analyze the relative expression of 96 atherosclerosis-related genes. Atherosclerosis is characterized by abnormal fatty deposits in and fibrosis of the inner layer of arteries. This progressive disease takes years to manifest itself as a partial or complete interruption of blood flow. Depending on the artery affected, atherosclerosis can lead to life-threatening acute conditions such as a heart attack or a stroke. It is a multi-factorial disease involving several different types of cells including endothelial cells, leukocytes and smooth muscle cells. Multiple biological processes are also involved such as cell-adhesion, inflammation, growth and apoptosis. Each of these pathways is represented on the array. Both in vivo and in vitro studies have demonstrated these genes to be important for the onset, progression and prevention of atherosclerosis. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 atherosclerosis-related genes.
Catalog number HS-038 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Cardiovascular Disease Gene Array II: Atherosclerosis

description:
The GEArray Q Series Mouse Cardiovascular Disease Gene Array II is designed to analyze the relative expression of 96 atherosclerosis-related genes. Atherosclerosis is characterized by abnormal fatty deposits in and fibrosis of the inner layer of arteries. This progressive disease takes years to manifest itself as a partial or complete interruption of blood flow. Depending on the artery affected, atherosclerosis can lead to life-threatening acute conditions such as a heart attack or a stroke. It is a multi-factorial disease involving several different types of cells including endothelial cells, leukocytes and smooth muscle cells. Multiple biological processes are also involved such as cell-adhesion, inflammation, growth and apoptosis. Each of these pathways is represented on the array. Both in vivo and in vitro studies have demonstrated these genes to be important for the onset, progression and prevention of atherosclerosis. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 atherosclerosis-related genes.
Catalog number MM-038 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Cardiovascular Disease Gene Array I: Biomarkers

description:
The GEArray Q Series Mouse Cardiovascular Disease Biomarkers Gene Array I is designed to analyze the expression of 96 genes involved in the manifestation of cardiovascular disease. Heart disease and stroke, the principal cardiovascular diseases, are the first and third leading cause of death in United States. The earlier manifestations of these diseases include hypertension as well as atherosclerosis, a complex process in which inflammation plays a central role. The genes on this array were selected based on published studies of in vivo and in vitro cardiovascular disease models. They are listed as ether biomarkers for risk of cardiovascular disease or genes associated with a failing or infracted heart. The processes regulated by the genes on this array include adhesion, inflammation, apoptosis, extracellular transport, and others. A complete expression profile of these genes should serve as an effective tool to unlock the molecular mechanisms that govern the onset and progression of cardiovascular diseases. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 biomarkers of cardiovascular diseases.
Catalog number MM-037 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Human Common Cytokine Gene Array

description:
Each GEArray Q series Human Common Cytokine Gene Array contains 96 common human cytokine genes. An important aspect of immunology is the determination of cytokine expression during cell activation, proliferation, and differentiation. In addition, cytokines play important and diverse roles in the regulation of the normal immune system and development, as well as roles in many diseases and pathologies, including cancer and diabetes. Through a simple side-by-side hybridization using the GEArray Q series Human Common Cytokine Gene Array kit, you can determine the cytokine expression profile under your experimental conditions. The cytokine genes represented on the array are listed below, grouped according to their gene family and/or functional roles.
Catalog number HS-003 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Cardiovascular Disease Gene Array I: Biomarkers

description:
The GEArray Q Series Human Cardiovascular Disease Biomarkers Gene Array I is designed to analyze the expression of 96 genes involved in the manifestation of cardiovascular disease. Heart disease and stroke, the principal cardiovascular diseases, are the first and third leading cause of death in United States. The earlier manifestations of these diseases include hypertension as well as atherosclerosis, a complex process in which inflammation plays a central role. The genes on this array were selected based on published studies of in vivo and in vitro cardiovascular disease models. They are listed as ether biomarkers for risk of cardiovascular disease or genes associated with a failing or infracted heart. The processes regulated by the genes on this array include adhesion, inflammation, apoptosis, extracellular transport, and others. A complete expression profile of these genes should serve as an effective tool to unlock the molecular mechanisms that govern the onset and progression of cardiovascular diseases. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 biomarkers of cardiovascular diseases.
Catalog number HS-037 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse Ca2+ /NF-AT Signaling Pathway Gene Array

description:
Each GEArray Q series Mouse Ca2+/NF-AT Signaling Pathway Gene Array contains 96 genes associated with signal transduction through Ca2+, calcineurin and the NF-AT transcription complex. Signaling through Ca2+/NF-AT is implicated in the regulation of inflammatory responses, allergic asthma, autoimmune diseases and cardiac hypertrophy and development. In a simple side-by-side hybridization experiment, using your RNA samples and GEArray Q series Mouse Ca2+/NF-AT Signaling Pathway Gene Array kit, you can characterize the expression profile of NF-AT family and related transcription factors, calcium signaling molecules, genes responsive to Ca2+/NF-AT signaling, and other genes involved in the Ca2+ /NF-AT signal transduction pathway.
Catalog number MM-022 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray S Series Mouse Autoimmune and Inflammatory Response Gene Array

description:
The GEArray S Series Mouse Autoimmune and Inflammatory Response Gene Array is designed to profile the expression of genes known to be involved in and important to immune responses such as autoimmunity and inflammation. It contains 364 known genes that encode adaptor proteins, cell surface receptors, cytokines and chemokines and their receptors, signal transduction proteins, transcription factors and other genes responsive to the autoimmune and inflammatory responses. Housekeeping and negative control genes are also included for background correction and normalization to generate relative gene expression profiles. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays and reagent provided in this kit, and a SuperArray probe synthesis kit (sold separately), you can simultaneously determine the expression profile of these 364 genes important to autoimmune and inflammatory responses.
Catalog number MM-602.3 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Human Ca2+ /NF-AT Signaling Pathway Gene Array

description:
Each GEArray Q series Human Ca2+/NF-AT Signaling Pathway Gene Array contains 96 genes associated with signal transduction through Ca2+, calcineurin and the NF-AT transcription complex. Signaling through Ca2+/NF-AT is implicated in the regulation of inflammatory responses, allergic asthma, autoimmune diseases and cardiac hypertrophy and development. In a simple side-by-side hybridization experiment, using your RNA samples and GEArray Q series Human Ca2+/NF-AT Signaling Pathway Gene Array kit, you can characterize the expression profile of NF-AT family and related transcription factors, calcium signaling molecules, genes responsive to Ca2+/NF-AT signaling, and other genes involved in the Ca2+ /NF-AT signal transduction pathway.
Catalog number HS-022 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Asthma Gene Array

description:
The GEArray Q Series Human Asthma Gene Array contains 85 genes pertinent to understanding asthma as a disease. The list of genes (see below) includes those encoding cytokines and their receptors, chemokines and their receptors, Th2 cytokine signaling molecules, and IgE receptors. Asthma is complex syndrome with many clinical manifestations. An elevation in the level of circulating IgE molecules can be indicative of allergies and asthma because these antibodies usually recognize the offending allergens. The IgE receptors on mast cells bind the IgE-antigen complexes and stimulate the cells to secrete cytokines and histamine that mediate the abnormally robust immune response. A shift in the T-helper cell population toward type 2 also plays an essential role in the pathogenesis of both allergies and asthma. Changes in the microbial environment may also account for the increasing prevalence of these conditions and the increase in Th2 populations. This concept may provide a conceptual basis for the development of new therapeutic strategies. Therefore, the Th2-specifc cytokines and the signaling pathway that regulates their expression have also been included on the array. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these asthma-related genes in your model system or patient- or animal- derived lavages.
Catalog number HS-033 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Asthma Gene Array

description:
The GEArray Q Series Mouse Asthma Gene Array contains 80 genes pertinent to understanding asthma as a disease. The list of genes (see below) includes those encoding cytokines and their receptors, chemokines and their receptors, Th2 cytokine signaling molecules, and IgE receptors. Asthma is complex syndrome with many clinical manifestations. An elevation in the level of circulating IgE molecules can be indicative of allergies and asthma because these antibodies usually recognize the offending allergens. The IgE receptors on mast cells bind the IgE-antigen complexes and stimulate the cells to secrete cytokines and histamine that mediate the abnormally robust immune response. A shift in the T-helper cell population toward type 2 also plays an essential role in the pathogenesis of both allergies and asthma. Changes in the microbial environment may also account for the increasing prevalence of these conditions and the increase in Th2 populations. This concept may provide a conceptual basis for the development of new therapeutic strategies. Therefore, the Th2-specifc cytokines and the signaling pathway that regulates their expression have also been included on the array. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these asthma-related genes in your model system or patient- or animal- derived lavages.
Catalog number MM-033 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Wnt Signaling Pathway Gene Array

description:
The GEArray Q Series Mouse Wnt Signaling Pathway Gene Array is designed to systematically profile the expression of genes involved in and downstream of Wnt signaling. The array includes the Wnt ligands and their receptors, intracellular signaling molecules, and representative target genes. The Wnt signaling pathway plays a pivotal role in embryonic development, causes tumorigenesis when aberrantly activated, and may also be involved in angiogenesis. The Wnt family is composed of roughly 20 glycosylated extracellular signaling molecules having corresponding receptors and antagonists. Wnt signaling proceeds through at least two pathways: the better understood canonical (Wnt / beta-catenin) pathway and the more newly discovered non-canonical (Wnt / calcium) pathway. Some Wnt proteins signal through the canonical pathway only, while others can signal through both pathways. Each Wnt ligand activates a unique set of target genes that mediate a specific biological response. Therefore, this array can be used to determine the pathway activation profile of a particular Wnt family member as well as the expression of genes related to Wnt signaling. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 genes in the Wnt signaling pathway.
Catalog number MM-043 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray S Series Human Autoimmune and Inflammatory Response Gene Array

description:
The GEArray S Series Human Autoimmune and Inflammatory Response Gene Array is designed to profile the expression of genes known to be involved in and important to immune responses such as autoimmunity and inflammation. It contains 364 known genes that encode for inflammatory cytokines, chemokines and their receptors, and T helper cell surface markers. It also contains representative signaling proteins and downstream targets of the signal transduction pathways that mediate the immune response: the NFkappaB, TGF-beta, and calcium / NFAT signaling pathways. Housekeeping and negative control genes are also included for background correction and normalization to generate relative gene expression profiles. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays and reagent provided in this kit, and a SuperArray probe synthesis kit (sold separately), you can simultaneously determine the expression profile of these 364 genes important to autoimmune and inflammatory responses.
Catalog number HS-602 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Wnt Signaling Pathway Gene Array

description:
The GEArray Q Series Human Wnt Signaling Pathway Gene Array is designed to systematically profile the expression of genes involved in and downstream of Wnt signaling. The array includes the Wnt ligands and their receptors, intracellular signaling molecules, and representative target genes. The Wnt signaling pathway plays a pivotal role in embryonic development, causes tumorigenesis when aberrantly activated, and may also be involved in angiogenesis. The Wnt family is composed of roughly 20 glycosylated extracellular signaling molecules having corresponding receptors and antagonists. Wnt signaling proceeds through at least two pathways: the better understood canonical (Wnt / beta-catenin) pathway and the more newly discovered non-canonical (Wnt / calcium) pathway. Some Wnt proteins signal through the canonical pathway only, while others can signal through both pathways. Each Wnt ligand activates a unique set of target genes that mediate a specific biological response. Therefore, this array can be used to determine the pathway activation profile of a particular Wnt family member as well as the expression of genes related to Wnt signaling. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 genes in the Wnt signaling pathway.
Catalog number HS-043 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse TGFb BMP Signaling Pathway Gene Array

description:
GEArray Q Series Mouse TGFb BMP Signaling Pathway Gene Array contains 96 genes, which encode members of the TGFb superfamily and key proteins involved in the TGFb signal transduction pathway. The TGFb superfamily of cytokines influences a diverse range of normal cellular processes, such as cell adhesion, cell proliferation, apoptosis, and secretion of extracellular matrix molecules. In addition, they are key molecules in many developmental processes, including body plan determination in embryos and organ morphogenesis in adults. Alteration of the signaling pathway has been linked to different disease processes, including developmental abnormalities and cancer progression. Through a simple side-by-side hybridization, using your RNA samples and the arrays and reagents provided, you can determine the expression profile of these TGFb / BMP related genes.
Catalog number MM-023 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Endothelial Cell Biology Gene Array

description:
The GEArray Q Series Endothelial Cell Biology Gene Array is designed to analyze the expression of genes associated with the major functions of endothelial cells including permissibility and vessel tone, angiogenesis, endothelial cell activation and endothelial cell injury. Endothelial cells play a critical role in the progression of disease processes including inflammation, atherosclerosis, and tumor angiogenesis. This GEArray can be used to easily characterize the biological state of endothelial cells in your experimental system or used to screen for drugs or biologicals that mimic or block a function of endothelial cells. Through a simple side-by-side hybridization, you can simultaneously determine the expression profile of these endothelial cell genes by using your experimental RNA samples, the arrays and the reagents provided in the kit, and a SuperArray Probe Synthesis Kit (sold separately).
Catalog number MM-036 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray S Series Mouse Dendritic & Antigen Presenting Cell Gene Array

description:
The GEArray S Series Mouse Dendritic & Antigen Presenting Cell Gene Array is designed for studying the expression profile of genes involved in dendritic cell activation and maturation. Dendritic cells, the most efficient antigen presenting cells, act as the first line of defense initiating specific immune responses to novel antigens. Immature cells reside in peripheral tissues where they ingest, accumulate and process antigens. The presence of antigen stimulates the cells to terminally differentiate, migrate to a lymph node, and present the antigen to naive T cells. Inflammatory signals, such as Toll-like receptor ligands and tumor necrosis factors, also induce dendritic cell differentiation. Dendritic cells also help maintain immune tolerance to self-antigens. This GEArray includes genes encoding proteins important for dendritic cell activation and maturation such as cytokines, chemokines and their receptors, other cell surface receptors, and signal transduction molecules. Proteins involved in antigen uptake, processing, and presentation are also represented by this array. In addition to being functionally defined, many of these genes on the array are highly expressed in mature dendritic cells or significantly change their expression during the differentiation program.
Catalog number MM-604 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray S Series Mouse Stem Cell Gene Array

description:
The GEArray S Series Mouse Stem Cell Gene Array is designed to profile the expression of genes known to be important for the identification, growth and differentiation of mouse stem cells. This microarray was developed in collaboration with Dr. Yongquan Luo and Mahendra Rao at the Stem Cell Biology Unit of the National Institute on Aging. It contains 258 known genes that encode markers expressed by stem cells at various stages of differentiation (91), growth factors and cytokines known to regulate stem cell growth (99), extracellular matrix molecules expressed at appropriate developmental stages (38), as well as other proteins such as cell cycle regulators that are thought to be involved in stem cell division. Positive controls and housekeeping genes are also included for normalization to generate relative expression profiles. The array is particularly useful in exploring neural stem cell development, but also contains markers for the identification and differentiation of embryonic, mesodermal and hematopoietic stem cells. Through a simple side-by-side hybridization, using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of important genes for stem cell growth and differentiation.
Catalog number MM-601.2 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Mouse Osteogenesis Gene Array

description:
GEArray Q series Mouse Osteogenesis Gene Array is designed to profile gene expression in the process of osteogenic differentiation. The osteogenesis is a complex process and it is regulated by signals with both extracellular and intracellular origins. The genes regulating this process include growth factors (BMPs and TGFb) and their internal cell signaling molecules (the smads), as well as the early and later differentiation genes (e.g. CBFA1 and osteocalcin, respectively). In addition, some skeletal-related genes are also known to play important roles for bone development. Now, using this Mouse Osteogenesis Gene Array, you can determine simultaneously the expression profile of the following 96 genes involved in the regulation of osteogenic differentiation. With the read-out of the array data in hand, you can launch a detailed mechanistic study on your cell/animal model or diseased sample.
Catalog number MM-026 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human TGFb BMP Signaling Pathway Gene Array

description:
GEArray Q Series Human TGFb BMP Signaling Pathway Gene Array contains 96 genes, which encode members of the TGFb superfamily and key proteins involved in the TGFb signal transduction pathway. The TGFb superfamily of cytokines influences a diverse range of normal cellular processes, such as cell adhesion, cell proliferation, apoptosis, and secretion of extracellular matrix molecules. In addition, they are key molecules in many developmental processes, including body plan determination in embryos and organ morphogenesis in adults. Alteration of the signaling pathway has been linked to different disease processes, including developmental abnormalities and cancer progression. Through a simple side-by-side hybridization, using your RNA samples and the arrays and reagents provided, you can determine the expression profile of these TGFb / BMP related genes.
Catalog number HS-023 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Endothelial Cell Biology Gene Array

description:
The GEArray Q Series Endothelial Cell Biology Gene Array is designed to analyze the expression of genes associated with the major functions of endothelial cells including permissibility and vessel tone, angiogenesis, endothelial cell activation and endothelial cell injury. Endothelial cells play a critical role in the progression of disease processes including inflammation, atherosclerosis, and tumor angiogenesis. This GEArray can be used to easily characterize the biological state of endothelial cells in your experimental system or used to screen for drugs or biologicals that mimic or block a function of endothelial cells. Through a simple side-by-side hybridization, you can simultaneously determine the expression profile of these endothelial cell genes by using your experimental RNA samples and the arrays and the reagents provided in the kit.
Catalog number HS-036 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q series Human Osteogenesis Gene Array

description:
GEArray Q series Human Osteogenesis Gene Array is designed to profile gene expression in the process of osteogenic differentiation. The osteogenesis is a complex process and it is regulated by signals with both extracellular and intracellular origins. The genes regulating this process include growth factors (BMPs and TGFb) and their internal cell signaling molecules (the smads), as well as the early and later differentiation genes (e.g. CBFA1 and osteocalcin, respectively). In addition, some skeletal-related genes are also known to play important roles for bone development. Now, using this Human Osteogenesis Gene Array, you can determine simultaneously the expression profile of the following 96 genes involved in the regulation of osteogenic differentiation. With the read-out of the array data in hand, you can launch a detailed mechanistic study on your cell/animal model or diseased sample.
Catalog number HS-026 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray Nylon-on-Glass GEArray: Human Dendritic & Antigen Presenting Cell Gene Array

description:
The Nylon-on-Glass GEArray Human Dendritic &  Antigen Presenting Cell Gene Array is designed for studying the expression profile of genes involved in dendritic cell activation and maturation. Dendritic cells, the most efficient antigen presenting cells, act as the first line of defense initiating specific immune responses to novel antigens. Immature cells reside in peripheral tissues where they ingest, accumulate and process antigens. The presence of antigen stimulates the cells to terminally differentiate, migrate to a lymph node, and present the antigen to naive T cells. Inflammatory signals, such as Toll-like receptor ligands and tumor necrosis factors, also induce dendritic cell differentiation. Dendritic cells also help maintain immune tolerance to self-antigens. This GEArray includes genes encoding proteins important for dendritic cell activation and maturation such as cytokines, chemokines and their receptors, other cell surface receptors, and signal transduction molecules. Proteins involved in antigen uptake, processing, and presentation are also represented by this array. In addition to being functionally defined, many of these genes on the array are highly expressed in mature dendritic cells or significantly change their expression during the differentiation program.
Catalog number HSV-604 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Cell Cycle Gene Array

description:
The GEArray Q Series Mouse Cell Cycle Gene Array was developed to profile the expression of 96 genes involved in cell cycle regulation. Cell cycle progression is precisely controlled by cyclin-dependent kinases (CDKs) and the proteins that regulate CDKs. These CDKs and CDK-modifying proteins, including cyclins, CDK inhibitors, CDK phosphatases, and CDK kinases, are featured in the Cell Cycle GEArray Q Series. Genes essential for DNA damage and mitotic spindle checkpoints, as well as genes in the SCF and APC ubiquitin-conjugation complexes, are also represented. Through a simple side-by-side hybridization, you can determine simultaneously the expression profile of these 96 genes involved in cell-cycle regulation by using your experimental RNA samples and the arrays and reagents provided in the kit.
Catalog number MM-001 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Cell Cycle Gene Array

description:
The GEArray Q Series Human Cell Cycle Gene Array Series was developed to profile the expression of 96 genes involved in cell cycle regulation. Cell cycle progression is precisely controlled by cyclin-dependent kinases (CDKs) and proteins that regulate CDKs. These CDKs and CDK-modifying proteins, including cyclins, CDK inhibitors, CDK phosphatases, and CDK kinases, are featured in the Human Cell Cycle GEArray Q Series. Genes essential for DNA damage and mitotic spindle checkpoints, as well as genes in the SCF and APC ubiquitin-conjugation complexes, are also represented. Through a simple side-by-side hybridization, using your experimental RNA samples and the arrays and reagents provided in the kit, you can determine simultaneously the expression profile of these 96 genes involved in cell cycle regulation.
Catalog number HS-001 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray S Series Human Dendritic & Antigen Presenting Cell Gene Array

description:
The GEArray S Series Human Dendritic & Antigen Presenting Cell Gene Array is designed for studying the expression profile of genes involved in dendritic cell activation and maturation. Dendritic cells, the most efficient antigen presenting cells, act as the first line of defense initiating specific immune responses to novel antigens. Immature cells reside in peripheral tissues where they ingest, accumulate and process antigens. The presence of antigen stimulates the cells to terminally differentiate, migrate to a lymph node, and present the antigen to naive T cells. Inflammatory signals, such as Toll-like receptor ligands and tumor necrosis factors, also induce dendritic cell differentiation. Dendritic cells also help maintain immune tolerance to self-antigens. This GEArray includes genes encoding proteins important for dendritic cell activation and maturation such as cytokines, chemokines and their receptors, other cell surface receptors, and signal transduction molecules. Proteins involved in antigen uptake, processing, and presentation are also represented by this array. In addition to being functionally defined, many of these genes on the array are highly expressed in mature dendritic cells or significantly change their expression during the differentiation program.
Catalog number HS-604 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Mouse Tumor Metastasis Gene Array

description:
The GEArray Q Series Mouse Tumor Metastasis Gene Array is designed to represent 96 genes known to be involved in metastasis. This array (see the list below) contains genes that encode for several classes of protein factors including growth factors and their receptors, ECM components, proteases and their inhibitors, oncogenes and suppressors, and other related genes. This array can help you understand the molecular mechanism of metastasis or determine how a tumor metastasized. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these genes involved in metastasis.
Catalog number MM-007 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Tumor Metastasis Gene Array

description:
The GEArray Q Series Human Tumor Metastasis Gene Array is designed to represent 96 genes known to be involved in metastasis. This array (see the list below) contains genes that encode for several classes of protein factors including growth factors and their receptors, ECM components, proteases and their inhibitors, oncogenes and suppressors, and other related genes. This array can help you understand the molecular mechanism of metastasis or determine how a tumor metastasized. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these genes involved in metastasis.
Catalog number HS-007 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray S Series Human Stem Cell Gene Array

description:
The GEArray S Series Human Stem Cell Gene Array is designed to profile the expression of genes known to be important for the identification, growth and differentiation of mouse stem cells. This microarray was developed in collaboration with Dr. Yongquan Luo and Mahendra Rao at the Stem Cell Biology Unit of the National Institute on Aging. It contains 266 known genes that encode markers expressed by stem cells at various stages of differentiation (86), growth factors and cytokines known to regulate stem cell growth (96), extracellular matrix molecules expressed at appropriate developmental stages (36), as well as other proteins such as cell cycle regulators that are thought to be involved in stem cell division. Positive controls and housekeeping genes are also included for normalization to generate relative expression profiles. The array is particularly useful in exploring neural stem cell development, but also contains markers for the identification and differentiation of embryonic, mesodermal and hematopoietic stem cells. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of important genes for stem cell growth and differentiation.
Catalog number HS-601.2 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Signal Transduction in Cancer Gene Array

description:
The GEArray Q Series Human Signal Transduction in Cancer Gene Array contains 96 genes that are indicators or markers for the activation of 15 different signal transduction pathways involved in oncogenesis. The following signaling pathways are all represented on this array: MAP kinase, WNT, Hedgehog, STAT, stress (DNA damage, p53, hypoxia, heat shock, and p38 / JNK), inflammation (Cox-2 and NFkB), survival (NFkB and PI3K / AKT), hormonal (estrogen and androgen), and anti-proliferation (TGFb). The characteristics of an individual tumor depend on its tissue of origin as well as genetic and environmental factors. A unique combination of pathways is thus activated or inactivated in each tumor leading to uncontrolled growth. The ability to profile multiple pathways at once allows for a rapid assessment of all of the possible routes to tumor formation. Therefore, this GEArray is not only an effective tool to determine the pathways associated with particular tumors or immortalized cells, but could also be a novel tool for cancer typing. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 markers of signal transduction pathways involved in tumorigenesis.
Catalog number HS-044 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php


title: SuperArray GEArray Q Series Human Genome Stability/DNA Repair Gene Array

description:
The GEArray Q Series Human Genome Stability / DNA Repair Gene Array kit is designed to profile the expression of human genes known to be associated with maintaining genome stability. In mammalian cells, a network of biochemical pathways exists to maintain the functional and structural integrity of genome. The DNA repair system (including base, nucleotide, and mismatch excision) is a one of the major defense mechanisms cells use to minimize DNA mutations, damage, and replication errors. On the array, human genes are also included that share sequence homology with repair genes found in other organisms but whose function has yet to be verified in mammalian systems. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 genes important for the maintenance of the genome.
Catalog number HS-042 (Superarray, Frederick, MD)
Platform_weblink: http://www.superarray.com/home.php