title: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep3_82258

description:
HybID: 82258
treated sample for experiment (RepID) 5194
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205081: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep2_82257
Replicate experimental sample: GSM205080: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep1_82259
Matched control sample: GSM204715: LIVER_vehicle_NA_1days_control_NA_81877
Matched control sample: GSM204638: LIVER_vehicle_NA_1days_control_NA_81878
Matched control sample: GSM204690: LIVER_vehicle_NA_1days_control_NA_81879
Matched control sample: GSM204730: LIVER_vehicle_NA_3days_control_NA_81880
Matched control sample: GSM204790: LIVER_vehicle_NA_3days_control_NA_81881
Matched control sample: GSM204772: LIVER_vehicle_NA_3days_control_NA_81882
Matched control sample: GSM204856: LIVER_vehicle_NA_5days_control_NA_81883
Matched control sample: GSM204832: LIVER_vehicle_NA_5days_control_NA_81884
Matched control sample: GSM204870: LIVER_vehicle_NA_5days_control_NA_81885
Matched control sample: GSM204631: LIVER_vehicle_NA_.25days_control_NA_81955
Matched control sample: GSM204624: LIVER_vehicle_NA_.25days_control_NA_81956
Matched control sample: GSM204597: LIVER_vehicle_NA_.25days_control_NA_81957
Matched control sample: GSM204652: LIVER_vehicle_NA_1days_control_NA_82304
Matched control sample: GSM204716: LIVER_vehicle_NA_1days_control_NA_82305
Matched control sample: GSM204699: LIVER_vehicle_NA_1days_control_NA_82306
Matched control sample: GSM204792: LIVER_vehicle_NA_3days_control_NA_82307
Matched control sample: GSM204779: LIVER_vehicle_NA_3days_control_NA_82308
Matched control sample: GSM204855: LIVER_vehicle_NA_5days_control_NA_82310
Matched control sample: GSM204869: LIVER_vehicle_NA_5days_control_NA_82311
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, TETRACYCLINE, 1500mg/kg, 5 days

value: TETRACYCLINE

value: WATER


title: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep2_84680

status: Public on Jun 23 2007

type: RNA

city: Mountain View

first: Jeremy

last: Gollub

state: CA

address: 325 E. Middlefield Rd.

country: USA

institute: Iconix Biosciences

description:
HybID: 84680
treated sample for experiment (RepID) 5328
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205103: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep3_83048
Replicate experimental sample: GSM205101: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep1_83049
Matched control sample: GSM204713: LIVER_vehicle_NA_1days_control_NA_83015
Matched control sample: GSM204692: LIVER_vehicle_NA_1days_control_NA_83016
Matched control sample: GSM204644: LIVER_vehicle_NA_1days_control_NA_83017
Matched control sample: GSM204786: LIVER_vehicle_NA_3days_control_NA_83019
Matched control sample: GSM204763: LIVER_vehicle_NA_3days_control_NA_83020
Matched control sample: GSM204866: LIVER_vehicle_NA_5days_control_NA_83021
Matched control sample: GSM204872: LIVER_vehicle_NA_5days_control_NA_83022
Matched control sample: GSM204805: LIVER_vehicle_NA_5days_control_NA_83023
Matched control sample: GSM204673: LIVER_vehicle_NA_1days_control_NA_83413
Matched control sample: GSM204706: LIVER_vehicle_NA_1days_control_NA_83414
Matched control sample: GSM204731: LIVER_vehicle_NA_3days_control_NA_83416
Matched control sample: GSM204773: LIVER_vehicle_NA_3days_control_NA_83417
Matched control sample: GSM204791: LIVER_vehicle_NA_3days_control_NA_83418
Matched control sample: GSM204842: LIVER_vehicle_NA_5days_control_NA_83504
Matched control sample: GSM204851: LIVER_vehicle_NA_5days_control_NA_83507
Matched control sample: GSM204809: LIVER_vehicle_NA_5days_control_NA_83508
Matched control sample: GSM204801: LIVER_vehicle_NA_5days_control_NA_83510
Matched control sample: GSM204858: LIVER_vehicle_NA_5days_control_NA_83519
Matched control sample: GSM204816: LIVER_vehicle_NA_5days_control_NA_83531
Matched control sample: GSM204854: LIVER_vehicle_NA_5days_control_NA_83532
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

hyb_protocol: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44. 12.5 ug of cRNA sample was fragmented in 40 mM Tris-acetate (TrisOAc) pH7.9, 100 mM KOAc and 31.5 mM MgOAc at 94oC for 20 min. This typically resulted in a fragmented cRNA with a size range between 100 to 200 bases. 10 ug of the fragmented cRNA was used for hybridization of each Rat-Uniset I (RU1) Expression BioArray (Amersham Biosciences, Piscataway, NJ) in a volume of 260 ul, containing 78 ul of CodeLink Hyb buffer component A and 130 ul of CodeLink Hyb buffer component B (Amersham Biosciences, Piscataway, NJ). The hybridization solution was denatured at 90oC for 5 min then chilled on ice. The sample was vortexed at maximum speed for 5 sec and centrifuged at maximum speed for 5 min before 250 ul of the solution was injected into the inlet port of the flex-hybridization chamber, and placed in a CodeLink 12-slide shaker tray. The hybridization ports were sealed with 1 cm sealing strips (Amersham Biosciences, Piscataway, NJ), and the shaker tray(s) containing the slides was loaded into a New Brunswick Innova 4080 shaking incubator, with the hybridization chambers facing up. Slides were incubated for 20 hr at 37oC, while shaking at 300 rpm. The 12-slide shaker tray was removed from the shaker, and the hybridization chamber removed from each slide. Each slide was placed into the BioArray Rack of the Parallel Processing Tool (Amersham Biosciences, Piscataway, NJ) and incubated with 0.75x TNT (0.075 M Tris-HCl, pH7.6, 0.1125 M NaCl, 0.0375 % Tween-20) at 46oC for 1hr. The BioArray Rack was moved from the TNT containing reservoir to the small reagent reservoir containing 1:500 dilution of streptavidin-Alexa 647 (Molecular Probes, Eugene, OR). The signal was developed for 30 min at room temperature, before the reaction was stopped and slides were washed four times for 5 min each in TNT buffer (0.1 M Tris-HCl, pH7.6, 0.15 M NaCl, 0.05% Tween-20) using a large reagent reservoir. The slides were rinsed in ddH2O with 0.05% Tween-20 twice for 5 sec each before they were dried by centrifugation with a Qiagen Sigma 4-15C centrifuge (Valencia, CA) using a swinging bucket rotor (2x96) for exactly 3 min at 2000rpm (acceleration at position 9 and deceleration at position 9). The dried slides were stored in light protective slide boxes at room temperature prior to scanning.

scan_protocol: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44. The Axon GenePix Scanner (Axon Instrument, Union City, CA) was calibrated using the Calibration Slide supplied by Axon Instrument with GenePix 4.0 at 635 nm using the Calibration System. After calibration of the scanner, all processed slides were scanned with the laser set to 635 nm, the photomultiplier tube (PMT) voltage to 600 and the scan resolution to 10 microns. For consistency all slides were scanned the same day of color development, within an hour after dry spinning them and the data was analyzed using the CodeLink Expression Analysis Software version 2.2.25 (Amersham Biosciences, Piscataway, NJ).

data_processing: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44, supplemental methods.  Prior to statistical computation, the spot reading data was normalized. For this purpose a new nonlinear normalization procedure, similar to the centralization approach reported in the literature (Zien et al., 2001) was developed for the CodeLink array platform. The normalization procedure uses proprietary algorithm that assumes that in general, for an array with many probes, the majority of the signal represents genes that have unchanged expressions compared to controls, with the extreme values representing the true biology of the process and not some artifact due to measurement noise. The algorithm does not make the assumption that the true mRNA abundance being measured is linearly proportional to the spot reading signal or any assumption about the error distribution of such signals or their differential. Rather, the assumption of unchanged signals representing the bulk of the signal measurements is used to center a nonlinear curve fit to a reference template. This reference template is constructed for a large set of time matched, same tissue and same vehicle, control arrays, computing a median log signal for each probe. The replicate size of this set is adequate to ensure very small random error in the ensemble signal level for each reference probe. The curve fit corrects for some array processing problems, such as partial signal saturation, and improves the overall quality of the data compared to simple linear normalization methods. Essentially the curve tracks the mode of the signal distribution for sets of genes against the expected value for that set.

label: biotin

molecule: polyA RNA

organism: Rattus norvegicus

source_name: LIVER, TRETINOIN, 7mg/kg, 5 days

label_protocol: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44. The methods used for cRNA preparation (cDNA synthesis, cRNA preparation, and cRNA purification) are essentially as described in the CodeLink™ manual v2.1 as supplied by Amersham Biosciences (Piscataway, NJ) using the Qiagen BioRobot 9604 (Valencia, CA). cDNA synthesis, cRNA preparation, and cRNA purification were completely processed in a 96-well format using the automated Qiagen BioRobot 9604 procedure. 0.6 – 20 ìg of enriched RNA from different tissue sources were added to a reaction mixture in a final volume of 12 ìl, containing bacterial control RNA (1.5pg FixA, 5pgYjeK, 5pg AraB, 15pg EntF, 50pg FixB, 150pg HisB, 500pg LeuB, 1500pg gnd) and 1.0 ìl of 100 pmol ìl-1 T7-(dT)24 oligonucleotide primer (Proligo, Boulder, CO). The T7-(dT)24 oligonucleotide primer used, is an HPLC purified 63-mer with the sequence : 5'-GGCCAGTGAATTGTAATACGACTCACTATAGGGAGGCGGTTTTTTTTTTTTTTTTTTTTTTTT-3'. The mixture was incubated for 10 min at 70oC and chilled on ice. On ice, 4 ul of 5x first-strand buffer, 2 ul 0.1 M DTT, 1 ul of 10 mM dNTP mix and 1 ul Superscript™II RNaseH-reverse transcriptase (200 U/ul) were added to the mixture to make a final volume of 20 ul. The mixture was incubated for 1 hr at 37oC. Second-strand cDNA was synthesized in a volume of 150 ul, containing 92 ul nuclease-free water, 30 ul of 5x second-strand buffer, 3 ul of 10 mM dNTP mix, 4 ul of Escherichia coli DNA polymerase I (10 U/ìl) and 1 ul of RNase H (2 U/ul) for 2 hr at 16oC. The cDNA was purified using a Qiagen QIAquick purification kit, and completely dried down using a Speed-Vac concentrator (45oC) for 2 hr. The dried product was resuspended in IVT reaction mix containing 3.0 ul of nuclease-free water, 4.0 ul 10x reaction buffer, 4.0 ul 75 mM ATP, 4.0 ul 75 mM GTP, 3.0 ul 75 mM CTP, 3.0 ul 75 mM UTP, 7.5 ul 10 mM Biotin 11-CTP, 7.5 ul 10 mM Biotin 11-UTP and 4.0 ul enzyme mix. The reaction mix was incubated for 14 hr at 37oC using an MJ Research 96-well PTC-200 Thermal Cycler (MJ Research, Waltham, MA), before the cRNA was purified using a Qiagen RNeasy® kit. The resulting cRNA yield was quantified using the 96-well ìQuan Universal Microplate Spectrophotometer Model MQX200 (BIO-TEK Instruments Inc., Winooski, VT) at a wavelength of 260 nm. Conformance of the cRNA sample to historical size distributions (the bulk of the cRNA product should be between 500 and 3,000 bases in size) was confirmed using the Agilent 2100 BioAnalyzer (Agilent Technologies, Palo Alto, CA). Samples not near the historical norm were reprocessed starting from tissue or RNA.

growth_protocol: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44.  Sprague-Dawley (Crl:CD®(SD)|GS BR) rats (aged 6-8 weeks and weighing 200 - 260 g), were purchased from Charles River Laboratories (Wilmington, MA). They were housed in plastic cages for 1 week for acclimation to the laboratory environment of a ventilated room (temperature, 22oC ±3oC; humidity, 30 - 70%; light/dark cycle, 12 h d-1, 6:00am - 6:00pm) until use. Certified Rodent Diet #5002 (PMI Feeds Inc.) and chlorinated tap water was available ad libitum.

extract_protocol: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44. Following sacrifice, 6 mm disposable biopsy punches (#REF 33-36 Miltex, Inc. Bethpage, NY) were used to obtain tissue samples of approximately 100 mg. Samples were placed in cryogenic tubes and snap frozen. Poly A(+)-RNA from tissue samples was isolated using the MagNA Pure LC robot (Roche, Basel, Switzerland) in combination with the MagNA Pure LC mRNA Isolation kit I and II (Roche, Basel, Switzerland) for cells (see supplemental methods section) and tissues, respectively. Tissue samples were completely homogenized directly from ~100 mg punches stored on dry ice prior to application of lysis buffer to a final concentration of 65 mg tissue per ml of buffer. After complete homogenization, using disposable Omni Tip Disposable Generator Probes (Omni Inc, Warrenton, VA) and before loading of the samples into the 32-well MagNA Pure plate, the samples were drawn up 5-6 times through a 20-gauge needle attached to a 3-ml syringe to ensure any tissue pieces or clumps were removed from the lysate prior to robotic processing. Tissue sample processing was performed in duplicate wells (loading 150 ul of homogenized sample to each well) of the MagNA Pure LC, which is programmed to extract mRNA using the oligo-dT selection method into a final elution volume of 100 ul. Poly A(+) RNA sample concentration was performed manually using a standard ethanol precipitation protocol in the presence of glycogen (50 ug/ml). After precipitation the final purified RNA sample was resuspended in 7 ìl DEPC-H2O and quantified using a Ribogreen high-range assay (Molecular Probes) on the Wallac Victor2 Fluorometer (Perkin-Elmer, Fremont, CA). Additionally, the integrity of each RNA sample was determined, by comparison to historical standards (no gross degradation should be visible as suggested by clear 18S and 28S peaks on top of a hump of complex RNA, with lower amounts of RNA below 18S than under and above the 18S peak), using the Agilent 2100 BioAnalyzer (Agilent Technologies, Palo Alto, CA) in combination with the RNA 6000 Nano Lab Chip kit (Agilent Technologies).

treatment_protocol: See Ganter et al., J Biotechnol. 2005 Sep 29;119(3):219-44.  Compounds were administered via the route of administration (ROA) that corresponds to that by which humans receive the drug. Compounds were typically administered orally (PO) (83%), intravenously (IV) (9.4%), subcutaneously (SC) (5.7%), or intraperitoneally (IP) (2%). If the compound is a toxicant or a biochemical standard, it was administered orally. For oral dosing, the vehicle choice largely depends on the solubility of the compound in water. Water-soluble compounds were administered in water. Insoluble compounds are administered in either corn oil or 0.5% carboxymethylcellulose (CMC) using the best literature recommendation as a guide. IV administered compounds were usually dissolved in saline and SC administered compounds in corn oil. The highest dose the rats receive is the Maximum Tolerated Dose (MTD). The dosing of animals was staggered based on intended harvest order to ensure that sacrifice occurred within 30 minutes of the recorded time point. Dosing frequency was as described in Sample_characteristics for the particular treatment.

tag: age

value: 6 to 8 weeks

tag: sex

value: male

tag: tissue

value: LIVER

tag: treatment compound

value: TRETINOIN

tag: dose

value: 7 mg/kg

tag: solvent

value: CORN OIL

tag: administration route

value: SUBCUTANEOUS

tag: frequency of dosing

value: DAILY

tag: treatment duration

value: 5 days

tag: experiment date


title: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep3_83048

description:
HybID: 83048
treated sample for experiment (RepID) 5328
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205101: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep1_83049
Replicate experimental sample: GSM205102: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep2_84680
Matched control sample: GSM204713: LIVER_vehicle_NA_1days_control_NA_83015
Matched control sample: GSM204692: LIVER_vehicle_NA_1days_control_NA_83016
Matched control sample: GSM204644: LIVER_vehicle_NA_1days_control_NA_83017
Matched control sample: GSM204786: LIVER_vehicle_NA_3days_control_NA_83019
Matched control sample: GSM204763: LIVER_vehicle_NA_3days_control_NA_83020
Matched control sample: GSM204866: LIVER_vehicle_NA_5days_control_NA_83021
Matched control sample: GSM204872: LIVER_vehicle_NA_5days_control_NA_83022
Matched control sample: GSM204805: LIVER_vehicle_NA_5days_control_NA_83023
Matched control sample: GSM204673: LIVER_vehicle_NA_1days_control_NA_83413
Matched control sample: GSM204706: LIVER_vehicle_NA_1days_control_NA_83414
Matched control sample: GSM204731: LIVER_vehicle_NA_3days_control_NA_83416
Matched control sample: GSM204773: LIVER_vehicle_NA_3days_control_NA_83417
Matched control sample: GSM204791: LIVER_vehicle_NA_3days_control_NA_83418
Matched control sample: GSM204842: LIVER_vehicle_NA_5days_control_NA_83504
Matched control sample: GSM204851: LIVER_vehicle_NA_5days_control_NA_83507
Matched control sample: GSM204809: LIVER_vehicle_NA_5days_control_NA_83508
Matched control sample: GSM204801: LIVER_vehicle_NA_5days_control_NA_83510
Matched control sample: GSM204858: LIVER_vehicle_NA_5days_control_NA_83519
Matched control sample: GSM204816: LIVER_vehicle_NA_5days_control_NA_83531
Matched control sample: GSM204854: LIVER_vehicle_NA_5days_control_NA_83532
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep2_83773

description:
HybID: 83773
treated sample for experiment (RepID) 5544
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205100: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep3_83708
Replicate experimental sample: GSM205098: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep1_83709
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, TOLAZAMIDE, 1500mg/kg, 5 days

value: TOLAZAMIDE

value: CMC

value: ORAL GAVAGE


title: LIVER_TRICHLOROACETIC_ACID_474mg/kg_5days_exp5568_rep2_83951

description:
HybID: 83951
treated sample for experiment (RepID) 5568
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205104: LIVER_TRICHLOROACETIC_ACID_474mg/kg_5days_exp5568_rep1_83950
Replicate experimental sample: GSM205106: LIVER_TRICHLOROACETIC_ACID_474mg/kg_5days_exp5568_rep3_83952
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, TRICHLOROACETIC ACID, 474mg/kg, 5 days

value: TRICHLOROACETIC ACID

value: 474 mg/kg


title: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep1_83709

description:
HybID: 83709
treated sample for experiment (RepID) 5544
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205100: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep3_83708
Replicate experimental sample: GSM205099: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep2_83773
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep3_83606

description:
HybID: 83606
treated sample for experiment (RepID) 5460
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205087: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep2_83605
Replicate experimental sample: GSM205086: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep1_83607
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, TICLOPIDINE, 223mg/kg, 5 days

value: TICLOPIDINE

value: 223 mg/kg


title: LIVER_THIOACETAMIDE_200mg/kg_5days_exp6941_rep2_88744

description:
HybID: 88744
treated sample for experiment (RepID) 6941
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205083: LIVER_THIOACETAMIDE_200mg/kg_5days_exp6941_rep1_88745
Replicate experimental sample: GSM205085: LIVER_THIOACETAMIDE_200mg/kg_5days_exp6941_rep3_88755
Matched control sample: GSM204686: LIVER_vehicle_NA_1days_control_NA_88722
Matched control sample: GSM204845: LIVER_vehicle_NA_5days_control_NA_88763
Matched control sample: GSM204696: LIVER_vehicle_NA_1days_control_NA_89140
Matched control sample: GSM204651: LIVER_vehicle_NA_1days_control_NA_89142
Matched control sample: GSM204800: LIVER_vehicle_NA_4days_control_NA_89144
Matched control sample: GSM204797: LIVER_vehicle_NA_4days_control_NA_89146
Matched control sample: GSM204635: LIVER_vehicle_NA_0days_control_NA_89148
Matched control sample: GSM204634: LIVER_vehicle_NA_0days_control_NA_89150
Matched control sample: GSM204722: LIVER_vehicle_NA_30days_control_NA_89231
Matched control sample: GSM204798: LIVER_vehicle_NA_4days_control_NA_89446
Matched control sample: GSM204875: LIVER_vehicle_NA_6days_control_NA_89484
Matched control sample: GSM204876: LIVER_vehicle_NA_6days_control_NA_89516
Matched control sample: GSM204799: LIVER_vehicle_NA_4days_control_NA_89522
Matched control sample: GSM204707: LIVER_vehicle_NA_1days_control_NA_89555
Matched control sample: GSM204670: LIVER_vehicle_NA_1days_control_NA_89557
Matched control sample: GSM204667: LIVER_vehicle_NA_1days_control_NA_89706
Matched control sample: GSM204769: LIVER_vehicle_NA_3days_control_NA_89709
Matched control sample: GSM204824: LIVER_vehicle_NA_5days_control_NA_89713
Matched control sample: GSM204879: LIVER_vehicle_NA_7days_control_NA_89818
Matched control sample: GSM204764: LIVER_vehicle_NA_3days_control_NA_89852
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, THIOACETAMIDE, 200mg/kg, 5 days

value: THIOACETAMIDE

value: 200 mg/kg

value: SALINE

value: INTRAPERITONEAL


title: LIVER_VALPROIC_ACID_1500mg/kg_5days_exp6082_rep1_85734

description:
HybID: 85734
treated sample for experiment (RepID) 6082
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205111: LIVER_VALPROIC_ACID_1500mg/kg_5days_exp6082_rep2_85756
Replicate experimental sample: GSM205112: LIVER_VALPROIC_ACID_1500mg/kg_5days_exp6082_rep3_85773
Matched control sample: GSM204808: LIVER_vehicle_NA_5days_control_NA_85526
Matched control sample: GSM204874: LIVER_vehicle_NA_5days_control_NA_85536
Matched control sample: GSM204676: LIVER_vehicle_NA_1days_control_NA_85576
Matched control sample: GSM204767: LIVER_vehicle_NA_3days_control_NA_85579
Matched control sample: GSM204829: LIVER_vehicle_NA_5days_control_NA_85582
Matched control sample: GSM204702: LIVER_vehicle_NA_1days_control_NA_85602
Matched control sample: GSM204653: LIVER_vehicle_NA_1days_control_NA_85604
Matched control sample: GSM204749: LIVER_vehicle_NA_3days_control_NA_85605
Matched control sample: GSM204788: LIVER_vehicle_NA_3days_control_NA_85607
Matched control sample: GSM204841: LIVER_vehicle_NA_5days_control_NA_85609
Matched control sample: GSM204668: LIVER_vehicle_NA_1days_control_NA_85835
Matched control sample: GSM204709: LIVER_vehicle_NA_1days_control_NA_85837
Matched control sample: GSM204734: LIVER_vehicle_NA_3days_control_NA_85839
Matched control sample: GSM204822: LIVER_vehicle_NA_5days_control_NA_85841
Matched control sample: GSM204864: LIVER_vehicle_NA_5days_control_NA_85843
Matched control sample: GSM204848: LIVER_vehicle_NA_5days_control_NA_85885
Matched control sample: GSM204605: LIVER_vehicle_NA_.25days_control_NA_85890
Matched control sample: GSM204628: LIVER_vehicle_NA_.25days_control_NA_85892
Matched control sample: GSM204710: LIVER_vehicle_NA_1days_control_NA_85897
Matched control sample: GSM204646: LIVER_vehicle_NA_1days_control_NA_85899
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, VALPROIC ACID, 1500mg/kg, 5 days

value: 6 to 8 weeks

value: male

value: LIVER

value: VALPROIC ACID

value: WATER


title: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep3_83708

description:
HybID: 83708
treated sample for experiment (RepID) 5544
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205098: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep1_83709
Replicate experimental sample: GSM205099: LIVER_TOLAZAMIDE_1500mg/kg_5days_exp5544_rep2_83773
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: DAILY

value: 5 days


title: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep3_86811

description:
HybID: 86811
treated sample for experiment (RepID) 6360
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205072: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep2_86812
Replicate experimental sample: GSM205071: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep1_86813
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, TESTOSTERONE, 375mg/kg, 5 days

value: TESTOSTERONE

value: 375 mg/kg

value: CMC


title: Recent-onset T1D_sample12

status: Public on Feb 22 2008

city: Milwaukee

first: Martin

last: Hessner

state: WI

address: 8701 Watertown Plank Road

department: Pediatrics

institute: Medical College of Wisconsin

description: Gene expression data from unstimulated Tregs from a recent-onset T1D subject

hyb_protocol: Purified total RNA (~50ng) was amplified using the two-cycle cDNA synthesis kit (Affymetrix, 900432) and cRNA was synthesized, labeled, fragmented and hybridized to the arrays in accordance to standard Affymetrix protocols (Affymetrix, Santa Clara, CA).

scan_protocol: After hybridization arrays were washed, stained with PE-conjugated streptavidin (Molecular Probes, Eugene, OR) and scanned on a GeneChip® Scanner 3000.

data_processing: Bayesian Hierarchical Analysis (using the BGX: R package) was used to find differentially expressed genes across 12 T1D and 15 controls. Details are in the supplementary notes to the accompanying paper.  For SAM analysis, we used RMA normalised intensity values as input. For analysis of 10 T1D and 10 Controls, we used adaptive MCMC methods and probe affinity effects.

molecule: total RNA

organism: Homo sapiens

source_name: Un-stimulated CD4+CD25+high regulatory T cells from PBMCs

label_protocol: Biotinylated cRNA were prepared according to the standard Affymetrix protocol from 6 ug total RNA (Expression Analysis Technical Manual, 2001, Affymetrix).

growth_protocol: Peripheral blood mononuclear cells (PBMCs) were collected using vacutainers with ACD solution B of trisodium citrate and isolated using Ficoll-Hypaque density centrifugation according to the recommended protocol (Amersham Pharmacia, Uppsala, Sweden).

extract_protocol: Total RNA was extracted from T cells using TRIzol Reagent (Invitrogen) according to the recommended protocol. The GeneChip® Human Genome U133 Plus 2.0 array was selected for this study which interrogates more than 47,000 probe sets, representing roughly 39,000 unique UniGenes.

treatment_protocol: The PBMCs were counted and stained with a cocktail of fluorochrome-conjugated monoclonal antibodies in PBS (APC-aCD4 (clone RPA-T4), APC-Cy7-aCD25 (clone M-A251), FITC-aCD14 (clone M5E2), FITC-aCD32 (clone FL18.26), FITC-aCD116 (cloneM5D12), PE-Cy7-aCD8 (clone RPA-T8) all from BD Pharmingen, San Diego, CA) and sorted on a FACSAria (BD Biosciences, San Diego, CA). Cells were first gated on the live lymphocyte population, eliminating dead cells and debris. Two additional gates were set up to eliminate non-CD4 T cells (FITC-stained cells and CD8-PE-Cy7 stained cells). CD4+ T cells were further gated as CD4+25- and CD4+CD25+high using the Fluorochrome Minus One (FMO) method, which allows for a more precise definition of cells having fluorescence above the background level. The 1% of cells expressing the highest level of CD25 were collected and defined as CD4+25+high T cells, known to be enriched for Tregs.

tag: HLA risk

value: High

tag: Height

tag: Weight

value: 77 kg

tag: BMI

tag: Age

value: 17.16 years

tag: Gender

value: Male

tag: Race

value: White

tag: Glucose

value: 260 mg/dl


title: LIVER_THIOACETAMIDE_200mg/kg_5days_exp6941_rep3_88755

description:
HybID: 88755
treated sample for experiment (RepID) 6941
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205084: LIVER_THIOACETAMIDE_200mg/kg_5days_exp6941_rep2_88744
Replicate experimental sample: GSM205083: LIVER_THIOACETAMIDE_200mg/kg_5days_exp6941_rep1_88745
Matched control sample: GSM204686: LIVER_vehicle_NA_1days_control_NA_88722
Matched control sample: GSM204845: LIVER_vehicle_NA_5days_control_NA_88763
Matched control sample: GSM204696: LIVER_vehicle_NA_1days_control_NA_89140
Matched control sample: GSM204651: LIVER_vehicle_NA_1days_control_NA_89142
Matched control sample: GSM204800: LIVER_vehicle_NA_4days_control_NA_89144
Matched control sample: GSM204797: LIVER_vehicle_NA_4days_control_NA_89146
Matched control sample: GSM204635: LIVER_vehicle_NA_0days_control_NA_89148
Matched control sample: GSM204634: LIVER_vehicle_NA_0days_control_NA_89150
Matched control sample: GSM204722: LIVER_vehicle_NA_30days_control_NA_89231
Matched control sample: GSM204798: LIVER_vehicle_NA_4days_control_NA_89446
Matched control sample: GSM204875: LIVER_vehicle_NA_6days_control_NA_89484
Matched control sample: GSM204876: LIVER_vehicle_NA_6days_control_NA_89516
Matched control sample: GSM204799: LIVER_vehicle_NA_4days_control_NA_89522
Matched control sample: GSM204707: LIVER_vehicle_NA_1days_control_NA_89555
Matched control sample: GSM204670: LIVER_vehicle_NA_1days_control_NA_89557
Matched control sample: GSM204667: LIVER_vehicle_NA_1days_control_NA_89706
Matched control sample: GSM204769: LIVER_vehicle_NA_3days_control_NA_89709
Matched control sample: GSM204824: LIVER_vehicle_NA_5days_control_NA_89713
Matched control sample: GSM204879: LIVER_vehicle_NA_7days_control_NA_89818
Matched control sample: GSM204764: LIVER_vehicle_NA_3days_control_NA_89852
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

tag: age

tag: sex

value: THIOACETAMIDE

value: 200 mg/kg

value: SALINE

value: INTRAPERITONEAL


title: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep1_83607

description:
HybID: 83607
treated sample for experiment (RepID) 5460
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205087: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep2_83605
Replicate experimental sample: GSM205088: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep3_83606
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: 6 to 8 weeks

value: male

tag: tissue

value: LIVER

tag: treatment compound

value: TICLOPIDINE

value: 223 mg/kg

value: ORAL GAVAGE


title: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep1_82259

description:
HybID: 82259
treated sample for experiment (RepID) 5194
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205081: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep2_82257
Replicate experimental sample: GSM205082: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep3_82258
Matched control sample: GSM204715: LIVER_vehicle_NA_1days_control_NA_81877
Matched control sample: GSM204638: LIVER_vehicle_NA_1days_control_NA_81878
Matched control sample: GSM204690: LIVER_vehicle_NA_1days_control_NA_81879
Matched control sample: GSM204730: LIVER_vehicle_NA_3days_control_NA_81880
Matched control sample: GSM204790: LIVER_vehicle_NA_3days_control_NA_81881
Matched control sample: GSM204772: LIVER_vehicle_NA_3days_control_NA_81882
Matched control sample: GSM204856: LIVER_vehicle_NA_5days_control_NA_81883
Matched control sample: GSM204832: LIVER_vehicle_NA_5days_control_NA_81884
Matched control sample: GSM204870: LIVER_vehicle_NA_5days_control_NA_81885
Matched control sample: GSM204631: LIVER_vehicle_NA_.25days_control_NA_81955
Matched control sample: GSM204624: LIVER_vehicle_NA_.25days_control_NA_81956
Matched control sample: GSM204597: LIVER_vehicle_NA_.25days_control_NA_81957
Matched control sample: GSM204652: LIVER_vehicle_NA_1days_control_NA_82304
Matched control sample: GSM204716: LIVER_vehicle_NA_1days_control_NA_82305
Matched control sample: GSM204699: LIVER_vehicle_NA_1days_control_NA_82306
Matched control sample: GSM204792: LIVER_vehicle_NA_3days_control_NA_82307
Matched control sample: GSM204779: LIVER_vehicle_NA_3days_control_NA_82308
Matched control sample: GSM204855: LIVER_vehicle_NA_5days_control_NA_82310
Matched control sample: GSM204869: LIVER_vehicle_NA_5days_control_NA_82311
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: TETRACYCLINE

tag: dose

tag: solvent

value: WATER

value: DAILY

value: 5 days


title: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep2_83605

description:
HybID: 83605
treated sample for experiment (RepID) 5460
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205088: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep3_83606
Replicate experimental sample: GSM205086: LIVER_TICLOPIDINE_223mg/kg_5days_exp5460_rep1_83607
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: CMC

tag: administration route

tag: frequency of dosing


title: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep1_83049

description:
HybID: 83049
treated sample for experiment (RepID) 5328
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205103: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep3_83048
Replicate experimental sample: GSM205102: LIVER_TRETINOIN_7mg/kg_5days_exp5328_rep2_84680
Matched control sample: GSM204713: LIVER_vehicle_NA_1days_control_NA_83015
Matched control sample: GSM204692: LIVER_vehicle_NA_1days_control_NA_83016
Matched control sample: GSM204644: LIVER_vehicle_NA_1days_control_NA_83017
Matched control sample: GSM204786: LIVER_vehicle_NA_3days_control_NA_83019
Matched control sample: GSM204763: LIVER_vehicle_NA_3days_control_NA_83020
Matched control sample: GSM204866: LIVER_vehicle_NA_5days_control_NA_83021
Matched control sample: GSM204872: LIVER_vehicle_NA_5days_control_NA_83022
Matched control sample: GSM204805: LIVER_vehicle_NA_5days_control_NA_83023
Matched control sample: GSM204673: LIVER_vehicle_NA_1days_control_NA_83413
Matched control sample: GSM204706: LIVER_vehicle_NA_1days_control_NA_83414
Matched control sample: GSM204731: LIVER_vehicle_NA_3days_control_NA_83416
Matched control sample: GSM204773: LIVER_vehicle_NA_3days_control_NA_83417
Matched control sample: GSM204791: LIVER_vehicle_NA_3days_control_NA_83418
Matched control sample: GSM204842: LIVER_vehicle_NA_5days_control_NA_83504
Matched control sample: GSM204851: LIVER_vehicle_NA_5days_control_NA_83507
Matched control sample: GSM204809: LIVER_vehicle_NA_5days_control_NA_83508
Matched control sample: GSM204801: LIVER_vehicle_NA_5days_control_NA_83510
Matched control sample: GSM204858: LIVER_vehicle_NA_5days_control_NA_83519
Matched control sample: GSM204816: LIVER_vehicle_NA_5days_control_NA_83531
Matched control sample: GSM204854: LIVER_vehicle_NA_5days_control_NA_83532
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: TRETINOIN

value: 7 mg/kg

value: CORN OIL

value: SUBCUTANEOUS

tag: treatment duration

tag: experiment date


title: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep2_82257

description:
HybID: 82257
treated sample for experiment (RepID) 5194
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205082: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep3_82258
Replicate experimental sample: GSM205080: LIVER_TETRACYCLINE_1500mg/kg_5days_exp5194_rep1_82259
Matched control sample: GSM204715: LIVER_vehicle_NA_1days_control_NA_81877
Matched control sample: GSM204638: LIVER_vehicle_NA_1days_control_NA_81878
Matched control sample: GSM204690: LIVER_vehicle_NA_1days_control_NA_81879
Matched control sample: GSM204730: LIVER_vehicle_NA_3days_control_NA_81880
Matched control sample: GSM204790: LIVER_vehicle_NA_3days_control_NA_81881
Matched control sample: GSM204772: LIVER_vehicle_NA_3days_control_NA_81882
Matched control sample: GSM204856: LIVER_vehicle_NA_5days_control_NA_81883
Matched control sample: GSM204832: LIVER_vehicle_NA_5days_control_NA_81884
Matched control sample: GSM204870: LIVER_vehicle_NA_5days_control_NA_81885
Matched control sample: GSM204631: LIVER_vehicle_NA_.25days_control_NA_81955
Matched control sample: GSM204624: LIVER_vehicle_NA_.25days_control_NA_81956
Matched control sample: GSM204597: LIVER_vehicle_NA_.25days_control_NA_81957
Matched control sample: GSM204652: LIVER_vehicle_NA_1days_control_NA_82304
Matched control sample: GSM204716: LIVER_vehicle_NA_1days_control_NA_82305
Matched control sample: GSM204699: LIVER_vehicle_NA_1days_control_NA_82306
Matched control sample: GSM204792: LIVER_vehicle_NA_3days_control_NA_82307
Matched control sample: GSM204779: LIVER_vehicle_NA_3days_control_NA_82308
Matched control sample: GSM204855: LIVER_vehicle_NA_5days_control_NA_82310
Matched control sample: GSM204869: LIVER_vehicle_NA_5days_control_NA_82311
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep1_86813

description:
HybID: 86813
treated sample for experiment (RepID) 6360
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205073: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep3_86811
Replicate experimental sample: GSM205072: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep2_86812
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: TESTOSTERONE

value: 375 mg/kg


title: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep1_84250

description:
HybID: 84250
treated sample for experiment (RepID) 5671
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205035: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep3_84248
Replicate experimental sample: GSM205034: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep2_84249
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, ROXITHROMYCIN, 312mg/kg, 5 days

value: 6 to 8 weeks

value: ROXITHROMYCIN

value: 312 mg/kg


title: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep3_86520

description:
HybID: 86520
treated sample for experiment (RepID) 6279
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205057: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep2_86521
Replicate experimental sample: GSM205056: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep1_86522
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, SPIRONOLACTONE, 300mg/kg, 5 days

value: male

value: LIVER

value: SPIRONOLACTONE

value: 300 mg/kg


title: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep2_84249

description:
HybID: 84249
treated sample for experiment (RepID) 5671
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205035: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep3_84248
Replicate experimental sample: GSM205033: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep1_84250
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: ORAL GAVAGE


title: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep2_86905

description:
HybID: 86905
treated sample for experiment (RepID) 6375
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205027: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep1_86867
Replicate experimental sample: GSM205029: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep3_86868
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, ROFECOXIB, 1550mg/kg, 5 days

value: ROFECOXIB

value: DAILY


title: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep3_84313

description:
HybID: 84313
treated sample for experiment (RepID) 5677
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205020: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep2_84314
Replicate experimental sample: GSM205019: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep1_84573
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, RABEPRAZOLE, 1024mg/kg, 5 days

value: RABEPRAZOLE

value: WATER

value: 5 days


title: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep3_84248

description:
HybID: 84248
treated sample for experiment (RepID) 5671
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205034: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep2_84249
Replicate experimental sample: GSM205033: LIVER_ROXITHROMYCIN_312mg/kg_5days_exp5671_rep1_84250
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: CMC


title: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep3_86868

description:
HybID: 86868
treated sample for experiment (RepID) 6375
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205027: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep1_86867
Replicate experimental sample: GSM205028: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep2_86905
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: CORN OIL


title: LIVER_RIFABUTIN_1500mg/kg_5days_exp6438_rep1_86958

description:
HybID: 86958
treated sample for experiment (RepID) 6438
replicate 1 of 2
Experimental sample
Replicate experimental sample: GSM205026: LIVER_RIFABUTIN_1500mg/kg_5days_exp6438_rep2_86959
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, RIFABUTIN, 1500mg/kg, 5 days

value: RIFABUTIN


title: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep1_84573

description:
HybID: 84573
treated sample for experiment (RepID) 5677
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205021: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep3_84313
Replicate experimental sample: GSM205020: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep2_84314
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep1_86522

description:
HybID: 86522
treated sample for experiment (RepID) 6279
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205058: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep3_86520
Replicate experimental sample: GSM205057: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep2_86521
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep2_84314

description:
HybID: 84314
treated sample for experiment (RepID) 5677
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205021: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep3_84313
Replicate experimental sample: GSM205019: LIVER_RABEPRAZOLE_1024mg/kg_5days_exp5677_rep1_84573
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep3_83667

description:
HybID: 83667
treated sample for experiment (RepID) 5527
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205007: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep1_83666
Replicate experimental sample: GSM205008: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep2_83864
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, PYRAZINAMIDE, 1500mg/kg, 5 days

value: PYRAZINAMIDE


title: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep2_82716

description:
HybID: 82716
treated sample for experiment (RepID) 5259
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205001: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep1_82717
Replicate experimental sample: GSM205003: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep3_82718
Matched control sample: GSM204726: LIVER_vehicle_NA_3days_control_NA_82309
Matched control sample: GSM204830: LIVER_vehicle_NA_5days_control_NA_82312
Matched control sample: GSM204698: LIVER_vehicle_NA_1days_control_NA_82496
Matched control sample: GSM204643: LIVER_vehicle_NA_1days_control_NA_82497
Matched control sample: GSM204733: LIVER_vehicle_NA_3days_control_NA_82499
Matched control sample: GSM204794: LIVER_vehicle_NA_3days_control_NA_82500
Matched control sample: GSM204774: LIVER_vehicle_NA_3days_control_NA_82501
Matched control sample: GSM204717: LIVER_vehicle_NA_1days_control_NA_82848
Matched control sample: GSM204704: LIVER_vehicle_NA_1days_control_NA_82849
Matched control sample: GSM204678: LIVER_vehicle_NA_1days_control_NA_82850
Matched control sample: GSM204725: LIVER_vehicle_NA_3days_control_NA_82851
Matched control sample: GSM204776: LIVER_vehicle_NA_3days_control_NA_82852
Matched control sample: GSM204795: LIVER_vehicle_NA_3days_control_NA_82853
Matched control sample: GSM204837: LIVER_vehicle_NA_5days_control_NA_82855
Matched control sample: GSM204860: LIVER_vehicle_NA_5days_control_NA_82949
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, PROPYLENE GLYCOL, 2000mg/kg, 5 days

value: 6 to 8 weeks

value: PROPYLENE GLYCOL


title: LIVER_RIFABUTIN_1500mg/kg_5days_exp6438_rep2_86959

description:
HybID: 86959
treated sample for experiment (RepID) 6438
replicate 2 of 2
Experimental sample
Replicate experimental sample: GSM205025: LIVER_RIFABUTIN_1500mg/kg_5days_exp6438_rep1_86958
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep2_83864

description:
HybID: 83864
treated sample for experiment (RepID) 5527
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205007: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep1_83666
Replicate experimental sample: GSM205009: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep3_83667
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep2_86521

description:
HybID: 86521
treated sample for experiment (RepID) 6279
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205058: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep3_86520
Replicate experimental sample: GSM205056: LIVER_SPIRONOLACTONE_300mg/kg_5days_exp6279_rep1_86522
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep2_83256

description:
HybID: 83256
treated sample for experiment (RepID) 5393
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205004: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep1_83255
Replicate experimental sample: GSM205006: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep3_83257
Matched control sample: GSM204713: LIVER_vehicle_NA_1days_control_NA_83015
Matched control sample: GSM204692: LIVER_vehicle_NA_1days_control_NA_83016
Matched control sample: GSM204644: LIVER_vehicle_NA_1days_control_NA_83017
Matched control sample: GSM204786: LIVER_vehicle_NA_3days_control_NA_83019
Matched control sample: GSM204763: LIVER_vehicle_NA_3days_control_NA_83020
Matched control sample: GSM204866: LIVER_vehicle_NA_5days_control_NA_83021
Matched control sample: GSM204872: LIVER_vehicle_NA_5days_control_NA_83022
Matched control sample: GSM204805: LIVER_vehicle_NA_5days_control_NA_83023
Matched control sample: GSM204673: LIVER_vehicle_NA_1days_control_NA_83413
Matched control sample: GSM204706: LIVER_vehicle_NA_1days_control_NA_83414
Matched control sample: GSM204731: LIVER_vehicle_NA_3days_control_NA_83416
Matched control sample: GSM204773: LIVER_vehicle_NA_3days_control_NA_83417
Matched control sample: GSM204791: LIVER_vehicle_NA_3days_control_NA_83418
Matched control sample: GSM204842: LIVER_vehicle_NA_5days_control_NA_83504
Matched control sample: GSM204851: LIVER_vehicle_NA_5days_control_NA_83507
Matched control sample: GSM204809: LIVER_vehicle_NA_5days_control_NA_83508
Matched control sample: GSM204801: LIVER_vehicle_NA_5days_control_NA_83510
Matched control sample: GSM204858: LIVER_vehicle_NA_5days_control_NA_83519
Matched control sample: GSM204816: LIVER_vehicle_NA_5days_control_NA_83531
Matched control sample: GSM204854: LIVER_vehicle_NA_5days_control_NA_83532
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, PROPYLTHIOURACIL, 625mg/kg, 5 days

value: PROPYLTHIOURACIL

value: 625 mg/kg


title: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep2_86812

description:
HybID: 86812
treated sample for experiment (RepID) 6360
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM205073: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep3_86811
Replicate experimental sample: GSM205071: LIVER_TESTOSTERONE_375mg/kg_5days_exp6360_rep1_86813
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: male

value: LIVER

value: TESTOSTERONE

value: 375 mg/kg


title: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep3_83257

description:
HybID: 83257
treated sample for experiment (RepID) 5393
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205004: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep1_83255
Replicate experimental sample: GSM205005: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep2_83256
Matched control sample: GSM204713: LIVER_vehicle_NA_1days_control_NA_83015
Matched control sample: GSM204692: LIVER_vehicle_NA_1days_control_NA_83016
Matched control sample: GSM204644: LIVER_vehicle_NA_1days_control_NA_83017
Matched control sample: GSM204786: LIVER_vehicle_NA_3days_control_NA_83019
Matched control sample: GSM204763: LIVER_vehicle_NA_3days_control_NA_83020
Matched control sample: GSM204866: LIVER_vehicle_NA_5days_control_NA_83021
Matched control sample: GSM204872: LIVER_vehicle_NA_5days_control_NA_83022
Matched control sample: GSM204805: LIVER_vehicle_NA_5days_control_NA_83023
Matched control sample: GSM204673: LIVER_vehicle_NA_1days_control_NA_83413
Matched control sample: GSM204706: LIVER_vehicle_NA_1days_control_NA_83414
Matched control sample: GSM204731: LIVER_vehicle_NA_3days_control_NA_83416
Matched control sample: GSM204773: LIVER_vehicle_NA_3days_control_NA_83417
Matched control sample: GSM204791: LIVER_vehicle_NA_3days_control_NA_83418
Matched control sample: GSM204842: LIVER_vehicle_NA_5days_control_NA_83504
Matched control sample: GSM204851: LIVER_vehicle_NA_5days_control_NA_83507
Matched control sample: GSM204809: LIVER_vehicle_NA_5days_control_NA_83508
Matched control sample: GSM204801: LIVER_vehicle_NA_5days_control_NA_83510
Matched control sample: GSM204858: LIVER_vehicle_NA_5days_control_NA_83519
Matched control sample: GSM204816: LIVER_vehicle_NA_5days_control_NA_83531
Matched control sample: GSM204854: LIVER_vehicle_NA_5days_control_NA_83532
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: ORAL GAVAGE


title: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep1_82717

description:
HybID: 82717
treated sample for experiment (RepID) 5259
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205002: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep2_82716
Replicate experimental sample: GSM205003: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep3_82718
Matched control sample: GSM204726: LIVER_vehicle_NA_3days_control_NA_82309
Matched control sample: GSM204830: LIVER_vehicle_NA_5days_control_NA_82312
Matched control sample: GSM204698: LIVER_vehicle_NA_1days_control_NA_82496
Matched control sample: GSM204643: LIVER_vehicle_NA_1days_control_NA_82497
Matched control sample: GSM204733: LIVER_vehicle_NA_3days_control_NA_82499
Matched control sample: GSM204794: LIVER_vehicle_NA_3days_control_NA_82500
Matched control sample: GSM204774: LIVER_vehicle_NA_3days_control_NA_82501
Matched control sample: GSM204717: LIVER_vehicle_NA_1days_control_NA_82848
Matched control sample: GSM204704: LIVER_vehicle_NA_1days_control_NA_82849
Matched control sample: GSM204678: LIVER_vehicle_NA_1days_control_NA_82850
Matched control sample: GSM204725: LIVER_vehicle_NA_3days_control_NA_82851
Matched control sample: GSM204776: LIVER_vehicle_NA_3days_control_NA_82852
Matched control sample: GSM204795: LIVER_vehicle_NA_3days_control_NA_82853
Matched control sample: GSM204837: LIVER_vehicle_NA_5days_control_NA_82855
Matched control sample: GSM204860: LIVER_vehicle_NA_5days_control_NA_82949
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: DAILY


title: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep1_86867

description:
HybID: 86867
treated sample for experiment (RepID) 6375
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205029: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep3_86868
Replicate experimental sample: GSM205028: LIVER_ROFECOXIB_1550mg/kg_5days_exp6375_rep2_86905
Matched control sample: GSM204831: LIVER_vehicle_NA_5days_control_NA_86647
Matched control sample: GSM204857: LIVER_vehicle_NA_5days_control_NA_86649
Matched control sample: GSM204721: LIVER_vehicle_NA_28days_control_NA_86650
Matched control sample: GSM204720: LIVER_vehicle_NA_28days_control_NA_86651
Matched control sample: GSM204880: LIVER_vehicle_NA_91days_control_NA_86653
Matched control sample: GSM204881: LIVER_vehicle_NA_91days_control_NA_86655
Matched control sample: GSM204701: LIVER_vehicle_NA_1days_control_NA_86693
Matched control sample: GSM204636: LIVER_vehicle_NA_1days_control_NA_86694
Matched control sample: GSM204747: LIVER_vehicle_NA_3days_control_NA_86714
Matched control sample: GSM204820: LIVER_vehicle_NA_5days_control_NA_86744
Matched control sample: GSM204664: LIVER_vehicle_NA_1days_control_NA_86757
Matched control sample: GSM204862: LIVER_vehicle_NA_5days_control_NA_86795
Matched control sample: GSM204783: LIVER_vehicle_NA_3days_control_NA_86796
Matched control sample: GSM204641: LIVER_vehicle_NA_1days_control_NA_86828
Matched control sample: GSM204814: LIVER_vehicle_NA_5days_control_NA_86831
Matched control sample: GSM204600: LIVER_vehicle_NA_.25days_control_NA_86882
Matched control sample: GSM204777: LIVER_vehicle_NA_3days_control_NA_86900
Matched control sample: GSM204627: LIVER_vehicle_NA_.25days_control_NA_86918
Matched control sample: GSM204748: LIVER_vehicle_NA_3days_control_NA_86923
Matched control sample: GSM204695: LIVER_vehicle_NA_1days_control_NA_87048
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: ROFECOXIB


title: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep1_83255

description:
HybID: 83255
treated sample for experiment (RepID) 5393
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205005: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep2_83256
Replicate experimental sample: GSM205006: LIVER_PROPYLTHIOURACIL_625mg/kg_5days_exp5393_rep3_83257
Matched control sample: GSM204713: LIVER_vehicle_NA_1days_control_NA_83015
Matched control sample: GSM204692: LIVER_vehicle_NA_1days_control_NA_83016
Matched control sample: GSM204644: LIVER_vehicle_NA_1days_control_NA_83017
Matched control sample: GSM204786: LIVER_vehicle_NA_3days_control_NA_83019
Matched control sample: GSM204763: LIVER_vehicle_NA_3days_control_NA_83020
Matched control sample: GSM204866: LIVER_vehicle_NA_5days_control_NA_83021
Matched control sample: GSM204872: LIVER_vehicle_NA_5days_control_NA_83022
Matched control sample: GSM204805: LIVER_vehicle_NA_5days_control_NA_83023
Matched control sample: GSM204673: LIVER_vehicle_NA_1days_control_NA_83413
Matched control sample: GSM204706: LIVER_vehicle_NA_1days_control_NA_83414
Matched control sample: GSM204731: LIVER_vehicle_NA_3days_control_NA_83416
Matched control sample: GSM204773: LIVER_vehicle_NA_3days_control_NA_83417
Matched control sample: GSM204791: LIVER_vehicle_NA_3days_control_NA_83418
Matched control sample: GSM204842: LIVER_vehicle_NA_5days_control_NA_83504
Matched control sample: GSM204851: LIVER_vehicle_NA_5days_control_NA_83507
Matched control sample: GSM204809: LIVER_vehicle_NA_5days_control_NA_83508
Matched control sample: GSM204801: LIVER_vehicle_NA_5days_control_NA_83510
Matched control sample: GSM204858: LIVER_vehicle_NA_5days_control_NA_83519
Matched control sample: GSM204816: LIVER_vehicle_NA_5days_control_NA_83531
Matched control sample: GSM204854: LIVER_vehicle_NA_5days_control_NA_83532
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep1_83666

description:
HybID: 83666
treated sample for experiment (RepID) 5527
replicate 1 of 3
Experimental sample
Replicate experimental sample: GSM205009: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep3_83667
Replicate experimental sample: GSM205008: LIVER_PYRAZINAMIDE_1500mg/kg_5days_exp5527_rep2_83864
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf


title: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep3_82718

description:
HybID: 82718
treated sample for experiment (RepID) 5259
replicate 3 of 3
Experimental sample
Replicate experimental sample: GSM205002: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep2_82716
Replicate experimental sample: GSM205001: LIVER_PROPYLENE_GLYCOL_2000mg/kg_5days_exp5259_rep1_82717
Matched control sample: GSM204726: LIVER_vehicle_NA_3days_control_NA_82309
Matched control sample: GSM204830: LIVER_vehicle_NA_5days_control_NA_82312
Matched control sample: GSM204698: LIVER_vehicle_NA_1days_control_NA_82496
Matched control sample: GSM204643: LIVER_vehicle_NA_1days_control_NA_82497
Matched control sample: GSM204733: LIVER_vehicle_NA_3days_control_NA_82499
Matched control sample: GSM204794: LIVER_vehicle_NA_3days_control_NA_82500
Matched control sample: GSM204774: LIVER_vehicle_NA_3days_control_NA_82501
Matched control sample: GSM204717: LIVER_vehicle_NA_1days_control_NA_82848
Matched control sample: GSM204704: LIVER_vehicle_NA_1days_control_NA_82849
Matched control sample: GSM204678: LIVER_vehicle_NA_1days_control_NA_82850
Matched control sample: GSM204725: LIVER_vehicle_NA_3days_control_NA_82851
Matched control sample: GSM204776: LIVER_vehicle_NA_3days_control_NA_82852
Matched control sample: GSM204795: LIVER_vehicle_NA_3days_control_NA_82853
Matched control sample: GSM204837: LIVER_vehicle_NA_5days_control_NA_82855
Matched control sample: GSM204860: LIVER_vehicle_NA_5days_control_NA_82949
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

value: WATER


title: LIVER_PRIMIDONE_750mg/kg_5days_exp5650_rep2_84291

description:
HybID: 84291
treated sample for experiment (RepID) 5650
replicate 2 of 3
Experimental sample
Replicate experimental sample: GSM204986: LIVER_PRIMIDONE_750mg/kg_5days_exp5650_rep1_84290
Replicate experimental sample: GSM204988: LIVER_PRIMIDONE_750mg/kg_5days_exp5650_rep3_84292
Matched control sample: GSM204850: LIVER_vehicle_NA_5days_control_NA_83512
Matched control sample: GSM204828: LIVER_vehicle_NA_5days_control_NA_83673
Matched control sample: GSM204674: LIVER_vehicle_NA_1days_control_NA_83735
Matched control sample: GSM204784: LIVER_vehicle_NA_3days_control_NA_83737
Matched control sample: GSM204724: LIVER_vehicle_NA_3days_control_NA_83739
Matched control sample: GSM204843: LIVER_vehicle_NA_5days_control_NA_83741
Matched control sample: GSM204700: LIVER_vehicle_NA_1days_control_NA_83831
Matched control sample: GSM204660: LIVER_vehicle_NA_1days_control_NA_83833
Matched control sample: GSM204766: LIVER_vehicle_NA_3days_control_NA_83835
Matched control sample: GSM204844: LIVER_vehicle_NA_5days_control_NA_83838
Matched control sample: GSM204659: LIVER_vehicle_NA_1days_control_NA_83978
Matched control sample: GSM204781: LIVER_vehicle_NA_3days_control_NA_83980
Matched control sample: GSM204741: LIVER_vehicle_NA_3days_control_NA_83982
Matched control sample: GSM204806: LIVER_vehicle_NA_5days_control_NA_83983
Matched control sample: GSM204852: LIVER_vehicle_NA_5days_control_NA_83985
Matched control sample: GSM204873: LIVER_vehicle_NA_5days_control_NA_84149
Matched control sample: GSM204648: LIVER_vehicle_NA_1days_control_NA_84194
Matched control sample: GSM204703: LIVER_vehicle_NA_1days_control_NA_84196
Matched control sample: GSM204758: LIVER_vehicle_NA_3days_control_NA_84198
Matched control sample: GSM204836: LIVER_vehicle_NA_5days_control_NA_84201
Guidelines for commercial use:
http://www.iconixbiosciences.com/guidelineCommUse.pdf

source_name: LIVER, PRIMIDONE, 750mg/kg, 5 days

value: PRIMIDONE

value: 750 mg/kg

value: 5 days