title: LP_5_2w_595_HZBZ5_10013_Liver

description: LP_5_2w_595_HZBZ5_10013_LiverF_(HT_Rat230_PM)_D03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: individual

tag: developmental state


title: LP_0_2w_584_RCC3_10013_Liver

status: Public on Apr 22 2013

type: RNA

city: RTP

first: Longlong

last: Yang

state: NC

address: 6 Davis Dr.

country: USA

institute: CIIT Centers for Health Research

description: LP_0_2w_584_RCC3_10013_LiverF_(HT_Rat230_PM)_C10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

hyb_protocol: standard Affymetrix procedures

scan_protocol: standard Affymetrix procedures

data_processing: RMA normalization with Partek software program

label: biotin

molecule: total RNA

organism: Rattus norvegicus

label_protocol: standard Affymetrix protocol

extract_protocol: Extraction Method: Qiagen

treatment_protocol: in vivo Treatment: Rodent Chow Control 3, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 0, Units of Dose or Concentration: ppm

tag: additional information

value: frozen into RLT

tag: array type

tag: amount to core

tag: units of amount

value: ul

tag: ratio

tag: rna integrity number

tag: bioanalyzer results

value: Excellent

tag: sample preservation

value: Frozen into RLT buffer

tag: strain or line

value: Adult

tag: sacrifice method

value: Pentobarbital, Exsanguinated

tag: Sex

value: Male

tag: age

tag: units of age

value: Weeks

tag: tissue

value: Liver

tag: tissue harvest methods

value: Slices from each of the lobes were pooled together for microarray analysis


title: LP_0_2w_583_RCC3_10013_Liver

description: LP_0_2w_583_RCC3_10013_LiverF_(HT_Rat230_PM)_C09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: individual


title: LP_500_13w_223_MDMB500_10011_Thyroid

description: LP_500_13w_223_MDMB500_10011_RThyroid_(HT_Rat230_PM)_B05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 500, Units of Dose or Concentration: ppm

tag: dilution

value: RNA Later

tag: developmental state

value: Female

value: Thyroid

value: The gland was transversely sectioned and the bottom portion was used for microarray analysis


title: LP_500_13w_224_MDMB500_10011_Thyroid

description: LP_500_13w_224_MDMB500_10011_RThyroid_(HT_Rat230_PM)_B07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_750_13w_235_MDMB750_10011_Thyroid

description: LP_750_13w_235_MDMB750_10011_RThyroid_(HT_Rat230_PM)_E05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 750, Units of Dose or Concentration: ppm

tag: units of amount

tag: ratio

value: Good


title: LP_375_13w_215_MDMB375_10011_Thyroid

description: LP_375_13w_215_MDMB375_10011_RThyroid_(HT_Rat230_PM)_H05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 375, Units of Dose or Concentration: ppm

tag: rna integrity number

tag: bioanalyzer results


title: LP_500_13w_222_MDMB500_10011_Thyroid

description: LP_500_13w_222_MDMB500_10011_RThyroid_(HT_Rat230_PM)_A07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_375_13w_213_MDMB375_10011_Thyroid

description: LP_375_13w_213_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_200_13w_206_MDMB200_10011_Thyroid

description: LP_200_13w_206_MDMB200_10011_RThyroid_(HT_Rat230_PM)_F05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 200, Units of Dose or Concentration: ppm

tag: age

tag: units of age


title: LP_500_13w_221_MDMB500_10011_Thyroid

description: LP_500_13w_221_MDMB500_10011_RThyroid_(HT_Rat230_PM)_A05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: tissue

tag: tissue harvest methods


title: LP_375_13w_211_MDMB375_10011_Thyroid

description: LP_375_13w_211_MDMB375_10011_RThyroid_(HT_Rat230_PM)_F07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: individual


title: LP_375_13w_212_MDMB375_10011_Thyroid

description: LP_375_13w_212_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: developmental state


title: LP_375_13w_216_MDMB375_10011_Thyroid

description: LP_375_13w_216_MDMB375_10011_RThyroid_(HT_Rat230_PM)_H07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_200_13w_205_MDMB200_10011_Thyroid

description: LP_200_13w_205_MDMB200_10011_RThyroid_(HT_Rat230_PM)_E07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_750_5d_54_MDMB750_10011_Thyroid

description: LP_750_5d_54_MDMB750_10011_RThyroid_(HT_Rat230_PM)_C04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 750, Units of Dose or Concentration: ppm

tag: rna integrity number

tag: bioanalyzer results


title: LP_0_13w_181_RCC1_10011_Thyroid

description: LP_0_13w_181_RCC1_10011_RThyroid_(HT_Rat230_PM)_H08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Rodent Chow Control 1, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 0, Units of Dose or Concentration: ppm

tag: sample preservation

tag: strain or line


title: LP_0_13w_183_RCC1_10011_Thyroid

description: LP_0_13w_183_RCC1_10011_RThyroid_(HT_Rat230_PM)_H10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_750_5d_53_MDMB750_10011_Thyroid

description: LP_750_5d_53_MDMB750_10011_RThyroid_(HT_Rat230_PM)_C03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age


title: LP_750_5d_56_MDMB750_10011_Thyroid

description: LP_750_5d_56_MDMB750_10011_RThyroid_(HT_Rat230_PM)_C06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: tissue


title: LP_50_13w_194_MDMB50_10011_Thyroid

description: LP_50_13w_194_MDMB50_10011_RThyroid_(HT_Rat230_PM)_C05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 50, Units of Dose or Concentration: ppm

tag: age

tag: tissue harvest methods


title: LP_200_13w_204_MDMB200_10011_Thyroid

description: LP_200_13w_204_MDMB200_10011_RThyroid_(HT_Rat230_PM)_E05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: individual


title: LP_750_5d_55_MDMB750_10011_Thyroid

description: LP_750_5d_55_MDMB750_10011_RThyroid_(HT_Rat230_PM)_C05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: developmental state


title: LP_50_13w_191_MDMB50_10011_Thyroid

description: LP_50_13w_191_MDMB50_10011_RThyroid_(HT_Rat230_PM)_A07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_50_13w_192_MDMB50_10011_Thyroid

description: LP_50_13w_192_MDMB50_10011_RThyroid_(HT_Rat230_PM)_B05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_0_13w_185_RCC1_10011_Thyroid

description: LP_0_13w_185_RCC1_10011_RThyroid_(HT_Rat230_PM)_H11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: bioanalyzer results


title: LP_200_13w_202_MDMB200_10011_Thyroid

description: LP_200_13w_202_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_200_13w_201_MDMB200_10011_Thyroid

description: LP_200_13w_201_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_750_5d_51_MDMB750_10011_Thyroid

description: LP_750_5d_51_MDMB750_10011_RThyroid_(HT_Rat230_PM)_C02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_0_13w_182_RCC1_10011_Thyroid

description: LP_0_13w_182_RCC1_10011_RThyroid_(HT_Rat230_PM)_H09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: age

tag: tissue harvest methods


title: LP_50_13w_193_MDMB50_10011_Thyroid

description: LP_50_13w_193_MDMB50_10011_RThyroid_(HT_Rat230_PM)_B07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: individual


title: LP_500_5d_45_MDMB500_10011_Thyroid

description: LP_500_5d_45_MDMB500_10011_RThyroid_(HT_Rat230_PM)_C01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 500, Units of Dose or Concentration: ppm

tag: dilution

tag: developmental state


title: LP_500_5d_44_MDMB500_10011_Thyroid

description: LP_500_5d_44_MDMB500_10011_RThyroid_(HT_Rat230_PM)_B12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_500_5d_42_MDMB500_10011_Thyroid

description: LP_500_5d_42_MDMB500_10011_RThyroid_(HT_Rat230_PM)_B10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_500_5d_43_MDMB500_10011_Thyroid

description: LP_500_5d_43_MDMB500_10011_RThyroid_(HT_Rat230_PM)_B11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: bioanalyzer results


title: LP_500_5d_41_MDMB500_10011_Thyroid

description: LP_500_5d_41_MDMB500_10011_RThyroid_(HT_Rat230_PM)_B09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_375_5d_35_MDMB375_10011_Thyroid

description: LP_375_5d_35_MDMB375_10011_RThyroid_(HT_Rat230_PM)_B08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 375, Units of Dose or Concentration: ppm

tag: sacrifice method

tag: Sex


title: LP_200_5d_26_MDMB200_10011_Thyroid

description: LP_200_5d_26_MDMB200_10011_RThyroid_(HT_Rat230_PM)_B03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 200, Units of Dose or Concentration: ppm

tag: units of age

tag: tissue


title: LP_375_5d_34_MDMB375_10011_Thyroid

description: LP_375_5d_34_MDMB375_10011_RThyroid_(HT_Rat230_PM)_B07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: tissue harvest methods


title: LP_375_5d_33_MDMB375_10011_Thyroid

description: LP_375_5d_33_MDMB375_10011_RThyroid_(HT_Rat230_PM)_B06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id


title: LP_375_5d_31_MDMB375_10011_Thyroid

description: LP_375_5d_31_MDMB375_10011_RThyroid_(HT_Rat230_PM)_B04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: individual


title: LP_375_5d_32_MDMB375_10011_Thyroid

description: LP_375_5d_32_MDMB375_10011_RThyroid_(HT_Rat230_PM)_B05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution


title: LP_50_5d_18_MDMB50_10011_Thyroid

description: LP_50_5d_18_MDMB50_10011_RThyroid_(HT_Rat230_PM)_A10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 50, Units of Dose or Concentration: ppm

tag: developmental state


title: LP_200_5d_21_MDMB200_10011_Thyroid

description: LP_200_5d_21_MDMB200_10011_RThyroid_(HT_Rat230_PM)_A11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type


title: LP_200_5d_25_MDMB200_10011_Thyroid

description: LP_200_5d_25_MDMB200_10011_RThyroid_(HT_Rat230_PM)_B02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core


title: LP_50_5d_13_MDMB50_10011_Thyroid

description: LP_50_5d_13_MDMB50_10011_RThyroid_(HT_Rat230_PM)_A06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount


title: LP_50_5d_17_MDMB50_10011_Thyroid

description: LP_50_5d_17_MDMB50_10011_RThyroid_(HT_Rat230_PM)_A09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio


title: LP_0_5d_4_RCC1_10011_Thyroid

description: LP_0_5d_4_RCC1_10011_RThyroid_(HT_Rat230_PM)_A04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Rodent Chow Control 1, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 0, Units of Dose or Concentration: ppm

tag: rna integrity number


title: LP_200_5d_23_MDMB200_10011_Thyroid

description: LP_200_5d_23_MDMB200_10011_RThyroid_(HT_Rat230_PM)_B01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results


title: LP_0_5d_2_RCC1_10011_Thyroid

description: LP_0_5d_2_RCC1_10011_RThyroid_(HT_Rat230_PM)_A02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation


title: LP_750_4w_172_MDMB750_10011_Thyroid

description: LP_750_4w_172_MDMB750_10011_RThyroid_(HT_Rat230_PM)_H04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 750, Units of Dose or Concentration: ppm

tag: strain or line

tag: age


title: LP_0_5d_3_RCC1_10011_Thyroid

description: LP_0_5d_3_RCC1_10011_RThyroid_(HT_Rat230_PM)_A03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_50_5d_16_MDMB50_10011_Thyroid

description: LP_50_5d_16_MDMB50_10011_RThyroid_(HT_Rat230_PM)_A08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_750_4w_173_MDMB750_10011_Thyroid

description: LP_750_4w_173_MDMB750_10011_RThyroid_(HT_Rat230_PM)_H05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_0_5d_5_RCC1_10011_Thyroid

description: LP_0_5d_5_RCC1_10011_RThyroid_(HT_Rat230_PM)_A05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution


title: LP_0_5d_1_RCC1_10011_Thyroid

description: LP_0_5d_1_RCC1_10011_RThyroid_(HT_Rat230_PM)_A01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: developmental state


title: LP_50_5d_15_MDMB50_10011_Thyroid

description: LP_50_5d_15_MDMB50_10011_RThyroid_(HT_Rat230_PM)_A07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: individual


title: LP_750_4w_174_MDMB750_10011_Thyroid

description: LP_750_4w_174_MDMB750_10011_RThyroid_(HT_Rat230_PM)_H06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_750_4w_176_MDMB750_10011_Thyroid

description: LP_750_4w_176_MDMB750_10011_RThyroid_(HT_Rat230_PM)_H07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: rna integrity number


title: LP_200_5d_22_MDMB200_10011_Thyroid

description: LP_200_5d_22_MDMB200_10011_RThyroid_(HT_Rat230_PM)_A12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_500_4w_164_MDMB500_10011_Thyroid

description: LP_500_4w_164_MDMB500_10011_RThyroid_(HT_Rat230_PM)_G12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 500, Units of Dose or Concentration: ppm

tag: strain or line

tag: age


title: LP_500_4w_163_MDMB500_10011_Thyroid

description: LP_500_4w_163_MDMB500_10011_RThyroid_(HT_Rat230_PM)_G11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_500_4w_166_MDMB500_10011_Thyroid

description: LP_500_4w_166_MDMB500_10011_RThyroid_(HT_Rat230_PM)_H02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_500_4w_165_MDMB500_10011_Thyroid

description: LP_500_4w_165_MDMB500_10011_RThyroid_(HT_Rat230_PM)_H01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_750_4w_171_MDMB750_10011_Thyroid

description: LP_750_4w_171_MDMB750_10011_RThyroid_(HT_Rat230_PM)_H03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: developmental state


title: LP_500_4w_161_MDMB500_10011_Thyroid

description: LP_500_4w_161_MDMB500_10011_RThyroid_(HT_Rat230_PM)_G10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: individual


title: LP_200_4w_144_MDMB200_10011_Thyroid

description: LP_200_4w_144_MDMB200_10011_RThyroid_(HT_Rat230_PM)_G03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 200, Units of Dose or Concentration: ppm

tag: amount to core

tag: units of amount


title: LP_375_4w_154_MDMB375_10011_Thyroid

description: LP_375_4w_154_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 375, Units of Dose or Concentration: ppm

tag: ratio

tag: rna integrity number


title: LP_375_4w_152_MDMB375_10011_Thyroid

description: LP_375_4w_152_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_200_4w_145_MDMB200_10011_Thyroid

description: LP_200_4w_145_MDMB200_10011_RThyroid_(HT_Rat230_PM)_G04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: age


title: LP_375_4w_156_MDMB375_10011_Thyroid

description: LP_375_4w_156_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_200_4w_142_MDMB200_10011_Thyroid

description: LP_200_4w_142_MDMB200_10011_RThyroid_(HT_Rat230_PM)_G01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_200_4w_143_MDMB200_10011_Thyroid

description: LP_200_4w_143_MDMB200_10011_RThyroid_(HT_Rat230_PM)_G02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_50_4w_134_MDMB50_10011_Thyroid

description: LP_50_4w_134_MDMB50_10011_RThyroid_(HT_Rat230_PM)_F10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 50, Units of Dose or Concentration: ppm

tag: dilution

tag: developmental state


title: LP_0_4w_126_RCC1_10011_Thyroid

description: LP_0_4w_126_RCC1_10011_RThyroid_(HT_Rat230_PM)_F06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Rodent Chow Control 1, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 0, Units of Dose or Concentration: ppm

tag: array type

tag: individual


title: LP_0_4w_124_RCC1_10011_Thyroid

description: LP_0_4w_124_RCC1_10011_RThyroid_(HT_Rat230_PM)_F05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_50_4w_136_MDMB50_10011_Thyroid

description: LP_50_4w_136_MDMB50_10011_RThyroid_(HT_Rat230_PM)_F11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: rna integrity number


title: LP_0_4w_122_RCC1_10011_Thyroid

description: LP_0_4w_122_RCC1_10011_RThyroid_(HT_Rat230_PM)_F03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_375_4w_151_MDMB375_10011_Thyroid

description: LP_375_4w_151_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: age


title: LP_200_4w_141_MDMB200_10011_Thyroid

description: LP_200_4w_141_MDMB200_10011_RThyroid_(HT_Rat230_PM)_F12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_50_4w_133_MDMB50_10011_Thyroid

description: LP_50_4w_133_MDMB50_10011_RThyroid_(HT_Rat230_PM)_F09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_750_2w_115_MDMB750_10011_Thyroid

description: LP_750_2w_115_MDMB750_10011_RThyroid_(HT_Rat230_PM)_E12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 750, Units of Dose or Concentration: ppm

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_0_13w_186_RCC1_10011_Thyroid

description: LP_0_13w_186_RCC1_10011_RThyroid_(HT_Rat230_PM)_A05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: developmental state


title: LP_375_4w_155_MDMB375_10011_Thyroid

description: LP_375_4w_155_MDMB375_10011_RThyroid_(HT_Rat230_PM)_G08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: individual


title: LP_750_2w_114_MDMB750_10011_Thyroid

description: LP_750_2w_114_MDMB750_10011_RThyroid_(HT_Rat230_PM)_E11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_50_4w_132_MDMB50_10011_Thyroid

description: LP_50_4w_132_MDMB50_10011_RThyroid_(HT_Rat230_PM)_F08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: rna integrity number


title: LP_750_2w_116_MDMB750_10011_Thyroid

description: LP_750_2w_116_MDMB750_10011_RThyroid_(HT_Rat230_PM)_F01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_500_2w_105_MDMB500_10011_Thyroid

description: LP_500_2w_105_MDMB500_10011_RThyroid_(HT_Rat230_PM)_E08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 500, Units of Dose or Concentration: ppm

tag: strain or line

tag: age


title: LP_375_2w_96_MDMB375_10011_Thyroid

description: LP_375_2w_96_MDMB375_10011_RThyroid_(HT_Rat230_PM)_E03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 375, Units of Dose or Concentration: ppm

tag: sacrifice method

tag: Sex


title: LP_500_2w_102_MDMB500_10011_Thyroid

description: LP_500_2w_102_MDMB500_10011_RThyroid_(HT_Rat230_PM)_E05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_50_13w_196_MDMB50_10011_Thyroid

description: LP_50_13w_196_MDMB50_10011_RThyroid_(HT_Rat230_PM)_C07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_500_2w_103_MDMB500_10011_Thyroid

description: LP_500_2w_103_MDMB500_10011_RThyroid_(HT_Rat230_PM)_E06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: developmental state


title: LP_0_4w_121_RCC1_10011_Thyroid

description: LP_0_4w_121_RCC1_10011_RThyroid_(HT_Rat230_PM)_F02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: individual


title: LP_500_2w_104_MDMB500_10011_Thyroid

description: LP_500_2w_104_MDMB500_10011_RThyroid_(HT_Rat230_PM)_E07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_50_4w_131_MDMB50_10011_Thyroid

description: LP_50_4w_131_MDMB50_10011_RThyroid_(HT_Rat230_PM)_F07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: rna integrity number


title: LP_375_2w_93_MDMB375_10011_Thyroid

description: LP_375_2w_93_MDMB375_10011_RThyroid_(HT_Rat230_PM)_D11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_750_2w_112_MDMB750_10011_Thyroid

description: LP_750_2w_112_MDMB750_10011_RThyroid_(HT_Rat230_PM)_E09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: age


title: LP_750_2w_113_MDMB750_10011_Thyroid

description: LP_750_2w_113_MDMB750_10011_RThyroid_(HT_Rat230_PM)_E10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_0_4w_123_RCC1_10011_Thyroid

description: LP_0_4w_123_RCC1_10011_RThyroid_(HT_Rat230_PM)_F04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_500_2w_101_MDMB500_10011_Thyroid

description: LP_500_2w_101_MDMB500_10011_RThyroid_(HT_Rat230_PM)_E04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_375_2w_94_MDMB375_10011_Thyroid

description: LP_375_2w_94_MDMB375_10011_RThyroid_(HT_Rat230_PM)_E01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: developmental state


title: LP_375_2w_91_MDMB375_10011_Thyroid

description: LP_375_2w_91_MDMB375_10011_RThyroid_(HT_Rat230_PM)_D10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: individual


title: LP_375_2w_95_MDMB375_10011_Thyroid

description: LP_375_2w_95_MDMB375_10011_RThyroid_(HT_Rat230_PM)_E02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_200_2w_84_MDMB200_10011_Thyroid

description: LP_200_2w_84_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 200, Units of Dose or Concentration: ppm

tag: ratio

tag: rna integrity number


title: LP_200_2w_81_MDMB200_10011_Thyroid

description: LP_200_2w_81_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_200_2w_82_MDMB200_10011_Thyroid

description: LP_200_2w_82_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: age


title: LP_50_2w_79_MDMB50_10011_Thyroid

description: LP_50_2w_79_MDMB50_10011_RThyroid_(HT_Rat230_PM)_D04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 50, Units of Dose or Concentration: ppm

tag: sacrifice method

tag: Sex


title: LP_50_2w_71_MDMB50_10011_Thyroid

description: LP_50_2w_71_MDMB50_10011_RThyroid_(HT_Rat230_PM)_C12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue