title: LP_0_2w_68_RCC1_10011_Thyroid

description: LP_0_2w_68_RCC1_10011_RThyroid_(HT_Rat230_PM)_C11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Rodent Chow Control 1, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 0, Units of Dose or Concentration: ppm

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_0_2w_61_RCC1_10011_Thyroid

status: Public on Apr 22 2013

type: RNA

city: RTP

first: Longlong

last: Yang

state: NC

address: 6 Davis Dr.

country: USA

institute: CIIT Centers for Health Research

description: LP_0_2w_61_RCC1_10011_RThyroid_(HT_Rat230_PM)_C07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

hyb_protocol: standard Affymetrix procedures

scan_protocol: standard Affymetrix procedures

data_processing: RMA normalization with Partek software program

label: biotin

molecule: total RNA

organism: Rattus norvegicus

label_protocol: standard Affymetrix protocol

extract_protocol: Extraction Method: Qiagen

tag: array type

tag: amount to core

tag: units of amount

value: ul

tag: ratio

tag: dilution

tag: rna integrity number

tag: bioanalyzer results

value: Good

tag: sample preservation

value: RNA Later

tag: strain or line

tag: individual

tag: developmental state

value: Adult

tag: sacrifice method

value: Pentobarbital, Exsanguinated

tag: Sex

value: Female

tag: age

tag: units of age

value: Weeks

tag: tissue

value: Thyroid

value: The gland was transversely sectioned and the bottom portion was used for microarray analysis


title: LP_50_2w_73_MDMB50_10011_Thyroid

description: LP_50_2w_73_MDMB50_10011_RThyroid_(HT_Rat230_PM)_D01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 50, Units of Dose or Concentration: ppm

value: Excellent

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_0_2w_63_RCC1_10011_Thyroid

description: LP_0_2w_63_RCC1_10011_RThyroid_(HT_Rat230_PM)_C08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_50_2w_77_MDMB50_10011_Thyroid

description: LP_50_2w_77_MDMB50_10011_RThyroid_(HT_Rat230_PM)_D02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_0_2w_64_RCC1_10011_Thyroid

description: LP_0_2w_64_RCC1_10011_RThyroid_(HT_Rat230_PM)_C09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: rna integrity number


title: LP_50_2w_78_MDMB50_10011_Thyroid

description: LP_50_2w_78_MDMB50_10011_RThyroid_(HT_Rat230_PM)_D03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_400_13w_496_BRBZ400_10009_Liver

description: LP_400_13w_496_BRBZ400_10009_Liver_(HT_Rat230_PM)_E07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

extract_protocol:
Extraction Method: Trizol
Additional Purification Method: Qiagen

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 400, Units of Dose or Concentration: mg/kg

tag: strain or line

tag: individual

value: Male

value: Liver

value: Slices from each of the lobes were pooled together for microarray analysis


title: LP_200_2w_86_MDMB200_10011_Thyroid

description: LP_200_2w_86_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: 4,4’-Methylenebis(N,N-dimethyl)benzenamine, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: ad lib, Vehicle for Chemical: Rodent Chow, Route of Exposure: Diet, Dose or Concentration: 200, Units of Dose or Concentration: ppm

tag: developmental state

tag: sacrifice method


title: LP_400_13w_495_BRBZ400_10009_Liver

description: LP_400_13w_495_BRBZ400_10009_Liver_(HT_Rat230_PM)_E05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: Sex

tag: age


title: LP_400_4w_434_BRBZ400_10009_Liver

description: LP_400_4w_434_BRBZ400_10009_Liver_(HT_Rat230_PM)_H05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 400, Units of Dose or Concentration: mg/kg

tag: units of age

tag: tissue


title: LP_400_5d_312_BRBZ400_10009_Liver

description: LP_400_5d_312_BRBZ400_10009_Liver_(HT_Rat230_PM)_C03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 400, Units of Dose or Concentration: mg/kg

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_400_2w_376_BRBZ400_10009_Liver

description: LP_400_2w_376_BRBZ400_10009_Liver_(HT_Rat230_PM)_F01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 400, Units of Dose or Concentration: mg/kg

tag: array type

tag: amount to core


title: LP_400_13w_493_BRBZ400_10009_Liver

description: LP_400_13w_493_BRBZ400_10009_Liver_(HT_Rat230_PM)_D05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_200_2w_85_MDMB200_10011_Thyroid

description: LP_200_2w_85_MDMB200_10011_RThyroid_(HT_Rat230_PM)_D08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: rna integrity number


title: LP_400_5d_311_BRBZ400_10009_Liver

description: LP_400_5d_311_BRBZ400_10009_Liver_(HT_Rat230_PM)_C02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_400_5d_316_BRBZ400_10009_Liver

description: LP_400_5d_316_BRBZ400_10009_Liver_(HT_Rat230_PM)_C06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: individual


title: LP_400_13w_494_BRBZ400_10009_Liver

description: LP_400_13w_494_BRBZ400_10009_Liver_(HT_Rat230_PM)_D07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: developmental state

tag: sacrifice method


title: LP_0_2w_67_RCC1_10011_Thyroid

description: LP_0_2w_67_RCC1_10011_RThyroid_(HT_Rat230_PM)_C10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: Sex

tag: age


title: LP_400_13w_491_BRBZ400_10009_Liver

description: LP_400_13w_491_BRBZ400_10009_Liver_(HT_Rat230_PM)_C07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_400_5d_315_BRBZ400_10009_Liver

description: LP_400_5d_315_BRBZ400_10009_Liver_(HT_Rat230_PM)_C05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_400_5d_314_BRBZ400_10009_Liver

description: LP_400_5d_314_BRBZ400_10009_Liver_(HT_Rat230_PM)_C04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_400_4w_436_BRBZ400_10009_Liver

description: LP_400_4w_436_BRBZ400_10009_Liver_(HT_Rat230_PM)_H07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_400_4w_431_BRBZ400_10009_Liver

description: LP_400_4w_431_BRBZ400_10009_Liver_(HT_Rat230_PM)_H03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: rna integrity number


title: LP_400_4w_435_BRBZ400_10009_Liver

description: LP_400_4w_435_BRBZ400_10009_Liver_(HT_Rat230_PM)_H06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_400_2w_375_BRBZ400_10009_Liver

description: LP_400_2w_375_BRBZ400_10009_Liver_(HT_Rat230_PM)_E12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: individual


title: LP_300_13w_484_BRBZ300_10009_Liver

description: LP_300_13w_484_BRBZ300_10009_Liver_(HT_Rat230_PM)_B05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 300, Units of Dose or Concentration: mg/kg

tag: developmental state

tag: sacrifice method


title: LP_300_5d_306_BRBZ300_10009_Liver

description: LP_300_5d_306_BRBZ300_10009_Liver_(HT_Rat230_PM)_C01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 300, Units of Dose or Concentration: mg/kg

tag: Sex


title: LP_300_5d_304_BRBZ300_10009_Liver

description: LP_300_5d_304_BRBZ300_10009_Liver_(HT_Rat230_PM)_B11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age


title: LP_300_13w_481_BRBZ300_10009_Liver

description: LP_300_13w_481_BRBZ300_10009_Liver_(HT_Rat230_PM)_A05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: age

tag: tissue


title: LP_300_13w_483_BRBZ300_10009_Liver

description: LP_300_13w_483_BRBZ300_10009_Liver_(HT_Rat230_PM)_A07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue harvest methods


title: LP_300_5d_305_BRBZ300_10009_Liver

description: LP_300_5d_305_BRBZ300_10009_Liver_(HT_Rat230_PM)_B12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: amount to core


title: LP_400_2w_371_BRBZ400_10009_Liver

description: LP_400_2w_371_BRBZ400_10009_Liver_(HT_Rat230_PM)_E09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_400_2w_374_BRBZ400_10009_Liver

description: LP_400_2w_374_BRBZ400_10009_Liver_(HT_Rat230_PM)_E11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: rna integrity number


title: LP_300_13w_485_BRBZ300_10009_Liver

description: LP_300_13w_485_BRBZ300_10009_Liver_(HT_Rat230_PM)_B07_2: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results

tag: sample preservation


title: LP_300_13w_486_BRBZ300_10009_Liver

description: LP_300_13w_486_BRBZ300_10009_Liver_(HT_Rat230_PM)_C05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: individual


title: LP_400_2w_373_BRBZ400_10009_Liver

description: LP_400_2w_373_BRBZ400_10009_Liver_(HT_Rat230_PM)_E10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: developmental state

tag: sacrifice method


title: LP_300_4w_429_BRBZ300_10009_Liver

description: LP_300_4w_429_BRBZ300_10009_Liver_(HT_Rat230_PM)_H02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 300, Units of Dose or Concentration: mg/kg

tag: Sex

tag: units of age


title: LP_300_5d_303_BRBZ300_10009_Liver

description: LP_300_5d_303_BRBZ300_10009_Liver_(HT_Rat230_PM)_B10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: tissue


title: LP_400_4w_433_BRBZ400_10009_Liver

description: LP_400_4w_433_BRBZ400_10009_Liver_(HT_Rat230_PM)_H04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: age


title: LP_300_5d_302_BRBZ300_10009_Liver

description: LP_300_5d_302_BRBZ300_10009_Liver_(HT_Rat230_PM)_B09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: tissue harvest methods


title: LP_300_4w_425_BRBZ300_10009_Liver

description: LP_300_4w_425_BRBZ300_10009_Liver_(HT_Rat230_PM)_G12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_300_4w_424_BRBZ300_10009_Liver

description: LP_300_4w_424_BRBZ300_10009_Liver_(HT_Rat230_PM)_G11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: dilution


title: LP_300_2w_364_BRBZ300_10009_Liver

description: LP_300_2w_364_BRBZ300_10009_Liver_(HT_Rat230_PM)_E06_2: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 300, Units of Dose or Concentration: mg/kg

tag: rna integrity number

tag: bioanalyzer results


title: LP_300_4w_423_BRBZ300_10009_Liver

description: LP_300_4w_423_BRBZ300_10009_Liver_(HT_Rat230_PM)_G10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_200_13w_473_BRBZ200_10009_Liver

description: LP_200_13w_473_BRBZ200_10009_Liver_(HT_Rat230_PM)_G07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 200, Units of Dose or Concentration: mg/kg

tag: individual

tag: developmental state


title: LP_300_2w_363_BRBZ300_10009_Liver

description: LP_300_2w_363_BRBZ300_10009_Liver_(HT_Rat230_PM)_E05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_300_2w_365_BRBZ300_10009_Liver

description: LP_300_2w_365_BRBZ300_10009_Liver_(HT_Rat230_PM)_E07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of age

tag: tissue


title: LP_200_13w_472_BRBZ200_10009_Liver

description: LP_200_13w_472_BRBZ200_10009_Liver_(HT_Rat230_PM)_G05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: age


title: LP_200_5d_294_BRBZ200_10009_Liver

description: LP_200_5d_294_BRBZ200_10009_Liver_(HT_Rat230_PM)_B07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 200, Units of Dose or Concentration: mg/kg

tag: array type

tag: tissue harvest methods


title: LP_200_13w_474_BRBZ200_10009_Liver

description: LP_200_13w_474_BRBZ200_10009_Liver_(HT_Rat230_PM)_H05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: units of amount


title: LP_200_4w_416_BRBZ200_10009_Liver

description: LP_200_4w_416_BRBZ200_10009_Liver_(HT_Rat230_PM)_G07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 200, Units of Dose or Concentration: mg/kg

tag: ratio

tag: dilution


title: LP_200_13w_475_BRBZ200_10009_Liver

description: LP_200_13w_475_BRBZ200_10009_Liver_(HT_Rat230_PM)_H07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: bioanalyzer results


title: LP_200_5d_295_BRBZ200_10009_Liver

description: LP_200_5d_295_BRBZ200_10009_Liver_(HT_Rat230_PM)_B08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: sample preservation


title: LP_200_4w_411_BRBZ200_10009_Liver

description: LP_200_4w_411_BRBZ200_10009_Liver_(HT_Rat230_PM)_G05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: individual


title: LP_200_4w_417_BRBZ200_10009_Liver

description: LP_200_4w_417_BRBZ200_10009_Liver_(HT_Rat230_PM)_G08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: developmental state

tag: sacrifice method


title: LP_300_4w_427_BRBZ300_10009_Liver

description: LP_300_4w_427_BRBZ300_10009_Liver_(HT_Rat230_PM)_H01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: Sex

tag: units of age


title: LP_200_2w_353_BRBZ200_10009_Liver

description: LP_200_2w_353_BRBZ200_10009_Liver_(HT_Rat230_PM)_D11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 200, Units of Dose or Concentration: mg/kg

tag: ncbi taxonomy id

tag: tissue


title: LP_200_4w_418_BRBZ200_10009_Liver

description: LP_200_4w_418_BRBZ200_10009_Liver_(HT_Rat230_PM)_G09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: age


title: LP_200_4w_414_BRBZ200_10009_Liver

description: LP_200_4w_414_BRBZ200_10009_Liver_(HT_Rat230_PM)_G06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: tissue harvest methods


title: LP_300_2w_361_BRBZ300_10009_Liver

description: LP_300_2w_361_BRBZ300_10009_Liver_(HT_Rat230_PM)_E04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: ratio


title: LP_200_13w_471_BRBZ200_10009_Liver

description: LP_200_13w_471_BRBZ200_10009_Liver_(HT_Rat230_PM)_F07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: bioanalyzer results


title: LP_200_2w_352_BRBZ200_10009_Liver

description: LP_200_2w_352_BRBZ200_10009_Liver_(HT_Rat230_PM)_D10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: sample preservation


title: LP_200_2w_355_BRBZ200_10009_Liver

description: LP_200_2w_355_BRBZ200_10009_Liver_(HT_Rat230_PM)_E02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: strain or line

tag: individual


title: LP_200_5d_293_BRBZ200_10009_Liver

description: LP_200_5d_293_BRBZ200_10009_Liver_(HT_Rat230_PM)_B06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: developmental state

tag: sacrifice method


title: LP_300_2w_366_BRBZ300_10009_Liver

description: LP_300_2w_366_BRBZ300_10009_Liver_(HT_Rat230_PM)_E08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: Sex

tag: units of age


title: LP_200_5d_291_BRBZ200_10009_Liver

description: LP_200_5d_291_BRBZ200_10009_Liver_(HT_Rat230_PM)_B04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: tissue


title: LP_100_5d_285_BRBZ100_10009_Liver

description: LP_100_5d_285_BRBZ100_10009_Liver_(HT_Rat230_PM)_B01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 100, Units of Dose or Concentration: mg/kg

tag: array type


title: LP_100_13w_463_BRBZ100_10009_Liver

description: LP_100_13w_463_BRBZ100_10009_Liver_(HT_Rat230_PM)_D07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 100, Units of Dose or Concentration: mg/kg

tag: amount to core

tag: age


title: LP_200_5d_292_BRBZ200_10009_Liver

description: LP_200_5d_292_BRBZ200_10009_Liver_(HT_Rat230_PM)_B05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: tissue harvest methods


title: LP_100_4w_405_BRBZ100_10009_Liver

description: LP_100_4w_405_BRBZ100_10009_Liver_(HT_Rat230_PM)_G02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 100, Units of Dose or Concentration: mg/kg

tag: ratio

tag: dilution


title: LP_100_5d_287_BRBZ100_10009_Liver

description: LP_100_5d_287_BRBZ100_10009_Liver_(HT_Rat230_PM)_B03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: bioanalyzer results


title: LP_100_13w_464_BRBZ100_10009_Liver

description: LP_100_13w_464_BRBZ100_10009_Liver_(HT_Rat230_PM)_E05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_100_5d_283_BRBZ100_10009_Liver

description: LP_100_5d_283_BRBZ100_10009_Liver_(HT_Rat230_PM)_A12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: individual

tag: developmental state


title: LP_100_4w_406_BRBZ100_10009_Liver

description: LP_100_4w_406_BRBZ100_10009_Liver_(HT_Rat230_PM)_G03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_100_2w_346_BRBZ100_10009_Liver

description: LP_100_2w_346_BRBZ100_10009_Liver_(HT_Rat230_PM)_D09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 100, Units of Dose or Concentration: mg/kg

tag: ncbi taxonomy id

tag: units of age


title: LP_100_5d_286_BRBZ100_10009_Liver

description: LP_100_5d_286_BRBZ100_10009_Liver_(HT_Rat230_PM)_B02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: tissue


title: LP_200_2w_354_BRBZ200_10009_Liver

description: LP_200_2w_354_BRBZ200_10009_Liver_(HT_Rat230_PM)_E01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: age


title: LP_100_2w_345_BRBZ100_10009_Liver

description: LP_100_2w_345_BRBZ100_10009_Liver_(HT_Rat230_PM)_D08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: tissue harvest methods


title: LP_100_13w_466_BRBZ100_10009_Liver

description: LP_100_13w_466_BRBZ100_10009_Liver_(HT_Rat230_PM)_F05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: dilution


title: LP_100_4w_408_BRBZ100_10009_Liver

description: LP_100_4w_408_BRBZ100_10009_Liver_(HT_Rat230_PM)_G04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: bioanalyzer results


title: LP_100_5d_282_BRBZ100_10009_Liver

description: LP_100_5d_282_BRBZ100_10009_Liver_(HT_Rat230_PM)_A11: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_100_2w_343_BRBZ100_10009_Liver

description: LP_100_2w_343_BRBZ100_10009_Liver_(HT_Rat230_PM)_D06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: individual

tag: developmental state


title: LP_100_13w_465_BRBZ100_10009_Liver

description: LP_100_13w_465_BRBZ100_10009_Liver_(HT_Rat230_PM)_E07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sacrifice method

tag: Sex


title: LP_100_4w_404_BRBZ100_10009_Liver

description: LP_100_4w_404_BRBZ100_10009_Liver_(HT_Rat230_PM)_G01: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: units of age


title: LP_100_13w_461_BRBZ100_10009_Liver

description: LP_100_13w_461_BRBZ100_10009_Liver_(HT_Rat230_PM)_D05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: tissue


title: LP_200_2w_356_BRBZ200_10009_Liver

description: LP_200_2w_356_BRBZ200_10009_Liver_(HT_Rat230_PM)_E03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core

tag: age


title: LP_25_13w_455_BRBZ25_10009_Liver

description: LP_25_13w_455_BRBZ25_10009_Liver_(HT_Rat230_PM)_C05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 25, Units of Dose or Concentration: mg/kg

tag: units of amount

tag: tissue harvest methods


title: LP_25_13w_453_BRBZ25_10009_Liver

description: LP_25_13w_453_BRBZ25_10009_Liver_(HT_Rat230_PM)_B07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: dilution


title: LP_100_4w_401_BRBZ100_10009_Liver

description: LP_100_4w_401_BRBZ100_10009_Liver_(HT_Rat230_PM)_F12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: rna integrity number

tag: bioanalyzer results


title: LP_100_2w_341_BRBZ100_10009_Liver

description: LP_100_2w_341_BRBZ100_10009_Liver_(HT_Rat230_PM)_D05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: sample preservation

tag: strain or line


title: LP_25_13w_452_BRBZ25_10009_Liver

description: LP_25_13w_452_BRBZ25_10009_Liver_(HT_Rat230_PM)_F07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: individual

tag: developmental state


title: LP_25_5d_275_BRBZ25_10009_Liver

description: LP_25_5d_275_BRBZ25_10009_Liver_(HT_Rat230_PM)_A10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 5, Units of Duration: Days, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 25, Units of Dose or Concentration: mg/kg

tag: sacrifice method

tag: Sex


title: LP_25_5d_274_BRBZ25_10009_Liver

description: LP_25_5d_274_BRBZ25_10009_Liver_(HT_Rat230_PM)_A09: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: units of age


title: LP_25_13w_451_BRBZ25_10009_Liver

description: LP_25_13w_451_BRBZ25_10009_Liver_(HT_Rat230_PM)_A07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: tissue


title: LP_25_5d_273_BRBZ25_10009_Liver

description: LP_25_5d_273_BRBZ25_10009_Liver_(HT_Rat230_PM)_A08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: amount to core


title: LP_100_2w_344_BRBZ100_10009_Liver

description: LP_100_2w_344_BRBZ100_10009_Liver_(HT_Rat230_PM)_D07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: age


title: LP_25_5d_271_BRBZ25_10009_Liver

description: LP_25_5d_271_BRBZ25_10009_Liver_(HT_Rat230_PM)_A06: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: tissue harvest methods


title: LP_25_13w_456_BRBZ25_10009_Liver

description: LP_25_13w_456_BRBZ25_10009_Liver_(HT_Rat230_PM)_C07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: dilution

tag: rna integrity number


title: LP_25_2w_335_BRBZ25_10009_Liver

description: LP_25_2w_335_BRBZ25_10009_Liver_(HT_Rat230_PM)_D03: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 2, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 25, Units of Dose or Concentration: mg/kg

tag: bioanalyzer results

tag: sample preservation


title: LP_25_4w_396_BRBZ25_10009_Liver

description: LP_25_4w_396_BRBZ25_10009_Liver_(HT_Rat230_PM)_F08: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Bromobenzene, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 4, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 25, Units of Dose or Concentration: mg/kg

tag: strain or line

tag: individual


title: LP_25_4w_398_BRBZ25_10009_Liver

description: LP_25_4w_398_BRBZ25_10009_Liver_(HT_Rat230_PM)_F10: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: developmental state

tag: sacrifice method


title: LP_25_2w_336_BRBZ25_10009_Liver

description: LP_25_2w_336_BRBZ25_10009_Liver_(HT_Rat230_PM)_D04: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ncbi taxonomy id

tag: Sex


title: LP_25_5d_272_BRBZ25_10009_Liver

description: LP_25_5d_272_BRBZ25_10009_Liver_(HT_Rat230_PM)_A07: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: array type

tag: units of age


title: LP_0_13w_446_CC2_10009_Liver

description: LP_0_13w_446_CC2_10009_Liver_(HT_Rat230_PM)_A05: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

treatment_protocol: in vivo Treatment: Corn Oil Control 2, Treatment Repeat: 7, Units of Treatment Repeat: Days/Week, Treatment Duration: 13, Units of Duration: Weeks, Treatment Time: 1, Units of Treatment Time: exposure/day, Vehicle for Chemical: Corn Oil, Amount of Vehicle: 5, Route of Exposure: Gavage, Units of Amount of Vehicle: ml/kg, Dose or Concentration: 0, Units of Dose or Concentration: mg/kg

tag: amount to core

tag: tissue


title: LP_25_2w_331_BRBZ25_10009_Liver

description: LP_25_2w_331_BRBZ25_10009_Liver_(HT_Rat230_PM)_C12: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: units of amount

tag: age


title: LP_25_2w_334_BRBZ25_10009_Liver

description: LP_25_2w_334_BRBZ25_10009_Liver_(HT_Rat230_PM)_D02: 1470 rats were used in this study:  6 chemicals, 4 time points, and 6 dose groups (including control).  10 animals per group and 5 extra control animals.  Timepoints were 5d, 2w, 4w, and 13 weeks.  Doses varied with compound (Tribromobenzene: 0, 2.5, 5, 10, 25, 75; Bromobenzene: 0, 25, 100, 200, 300, 400; Tetrachlorophenol: 0, 10, 25, 50, 100, 200; Methylenebis(N,N-dimethyl)benzen amine: 0, 50, 200, 375, 500, 750; Nitrosodiphenylamine: 0, 250, 1000, 2000, 3000, 4000; Hydrazobenzene: 0, 5, 20, 80, 200, 300).  Animals were dosed through gavage or diet.  Two of the protocols had female rats and the rest were male rats (see protocols).  F344 and Sprague Dawley rats were used.

tag: ratio

tag: tissue harvest methods