title: METSIM1840

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1841

status: Public on Apr 01 2013

type: SRA

city: Los Angeles

first: Mete

last: Civelek

state: CA

address: 675 Charles E. Young Dr. S. MRL 3220

department: Medicine

country: USA

institute: University of California Los Angeles

library_source: transcriptomic

data_processing:
Illumina Casava1.7 software used for basecalling.
Sequencing files were converted to FASTQ format using a custom Perl script. In order to assign the indexed reads to each METSIM subject, a Python script was used to partition the FASTQ file for each lane into multiple FASTQ files, each of which corresponded to one individual. To be included in the partitioned file, a read had to have an exact match to one of the 48 possible index sequences, unambiguously identifying the individual from whom the read originated. Reads which did not exactly match an index sequence were discarded.
The reads were then aligned to the hg19 version of the genome using the Novoalign tool with the following settings: -l16 -t30 -h90 -rA -R 1 -m -g 200 –k.  Novoalign software trims the adapter sequences while aligning.
We used the Bioconductor package GenomicRanges for R (v.2.14.0) to count the number of reads with alignment coordinates that overlap the coordinates of known mature miRNAs. Whenever a read mapped to 'x' genomic loci, the read would contribute a count of 1/x to those regions. The genomic coordinates for known mature miRNAs were downloaded from miRBase version 18.
To enable comparison of counts between samples, we normalized the expression values by dividing the counts for a given mature miRNA by the sum of all the miRNA counts for the corresponding individual. For subsequent analysis, we considered the expression levels of 356 miRNAs that had at least 5 reads in half of the study participants.
Genome_build: hg19
Supplementary_files_format_and_content: tab-delimited text files include unnormalized weighted counts for each miRNA

molecule: total RNA

organism: Homo sapiens

source_name: adipose tissue

extract_protocol:
Abdominal subcutaneous adipose tissue was obtained with needle biopsies. Total RNA was isolated from the adipose tissue using Qiagen miRNeasy kit according to manufacturer’s instructions. RNA Integrity Number (RIN) values were assessed with the Agilent Bioanalyzer 2100 instrument. Samples with RIN values greater than 7.0 were used for transcriptional profiling.
Small RNA libraries were prepared using  the Illumina  TruSeq Small RNA protocol utilizing up to 48 unique index sequences (Illumina Catalog Number FC-102-1009). For two samples (METSIM490 and METSIM6589) we also prepared small RNA libraries using Illumina Small RNA v1.5 sample preparation protocol (Catalog # FC-930-1501)

treatment_protocol: We analyzed samples from 200 male human subjects that are part of the METSIM (METabolic Syndrome In Men) study. The population-based cross-sectional METSIM study included 10,197 men, aged from 45 to 73 years, who were randomly selected from the population register of the Kuopio town in eastern Finland (population 95,000). Every participant had a 1-day outpatient visit to the Clinical Research Unit at the University of Kuopio, including an interview on the history of previous diseases and current drug treatment and an evaluation of glucose tolerance and cardiovascular risk factors. After 12 hours of fasting, a 2-h oral 75-g glucose tolerance test was performed and the blood samples were drawn at 0, 30 and 120 min. Plasma glucose was measured by enzymatic hexokinase photometric assay (Konelab Systems reagents; Thermo Fischer Scientific, Vantaa, Finland). Insulin was determined by immunoassay (ADVIA Centaur Insulin IRI no. 02230141; Siemens Medical Solutions Diagnostics, Tarrytown, NY). Height and weight were measured to the nearest 0.5 cm and 0.1 kg, respectively. Waist (at the midpoint between the lateral iliac crest and lowest rib) and hip circumference (at the level of the trochanter major) were measured to the nearest 0.5 cm. Body composition was determined by bioelectrical impedance (RJL Systems) in subjects in the supine position after a 12-hour fast.

tag: age

tag: tissue

value: adipose tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1885

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1777

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1768

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1757

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1725

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1702

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1722

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1678

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1666

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1674

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1599

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1619

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1653

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1574

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1518

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1504

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1483

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1366

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1353

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1516

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1343

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1452

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1303

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1264

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1263

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1228

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1223

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1180

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1165

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1167

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1247

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1160

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1162

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1111

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1092

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM1086

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM906

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM908

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM1019

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM964

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM888

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM874

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM803

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM817

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM844

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM598

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM783

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM7927

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM575

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM388

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: CY110wh-RNAseq

city: beijing

first: Jing

last: Xie

address: NO.1 Beichen West Road, Chaoyang District

country: China

institute: Institute Of Microbiology Chinese Academy of Sciences

description: Sample 1

data_processing:
Illumina OLB_1.9.4 were used for basecalling.
Filter dirty raw reads by removing reads with adaptors and low quality, the obtained clean reads were mapped to reference sequences using SOAPaligner/soap2 according to Li et al., Bioinformatics, 2009. Mismatches no more than 2 bases were allowed in the alignment.
The gene expression level is calculated by using RPKM method (Reads Per kb per Million reads) according to Mortazavi, et a., Nature Methods, 2008, and the formula is shown as follows: RPKM=106C/(NL/103). C is the number of reads that uniquely aligned to a gene, N is total number of reads that uniquely aligned to all genes, and L is the number of bases on a gene .
Genome_build: Candida albicans SC5314 genome (ASM18296v1)
Supplementary_files_format_and_content: text files containing RPKM values for each Sample

organism: Candida albicans

source_name: Candida albicans cells

growth_protocol: white and opaque cells of strain CY110 were inoculated into Lee's Glucose medium and cultured at 25 oC for 12h.

extract_protocol:
Cells were lysed by beadbeater and total RNA was harvested using GeneJET RNA Purification Kit (Thermo Scientific #K0731, #K0732)
mRNA is enriched by using the oligo(dT) magnetic beads and interrupted to short fragments (about 200 bp), then the first strand cDNA is synthesized by random hexamer-primer using the mRNA fragments as templates. Buffer, dNTPs, RNase H and DNA polymerase I are added to sythsize the second strand. The double strand cDNA is purified with QiaQuick PCR extraction kit and washed with EB buffer for end repair and single nucleotide A (adenine) addition. Finally, sequencing adaptors are ligated to the fragments. The required fragments is purified by agrose gel electrophoresis and enriched by PCR amplification. The library products are ready for sequencing analysis via Illumina HiSeq™ 2000.

tag: cell type

value: white

tag: strain


title: METSIM473

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: CY110op-RNAseq

description: Sample 2

tag: cell type

value: opaque

tag: strain


title: METSIM492

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM522

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: METSIM482

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: muscle mass (%)

tag: lg10 serum c-reactive protein (mg/l)

tag: ogtt fasting plasma glucose (mmol/l)

tag: ogtt 30 min plasma glucose (mmol/l)

tag: ogtt 120 min plasma glucose (mmol/l)

tag: log10 il1 receptor antagonist (pg/ml)

tag: log10 il1 beta (pg/ml)

tag: log10 ogtt fasting plasma insulin (mu/l)

tag: ogtt 30 min plasma insulin (mu/l)

tag: log10 total cholesterol (mmol/l)

tag: log10 ldl cholesterol (mmol/l)

tag: log10 hdl cholesterol (mmol/l)

tag: log10 total triglycerides (mmol/l)

tag: log10 serum apoa1 (g/l)

tag: log10 serum apob (g/l)

tag: log10 urinary albumin excretion rate (ug/min)


title: METSIM490

tag: age

tag: tissue

tag: log10 body mass index

tag: log10 basal metabolic rate (kcal)

tag: log2 estimated glomerular filtration rate using modification of diet in renal disease (egfr_mdrd)

tag: log10 estimated creatinine clearance rate using cockfcrot-gault formulaa (egcr)

tag: plasma free fatty acids under the curve ogtt (mmol/l * min)

tag: fat mass (%)

tag: log10 plasma glucose area under the curve (ogtt) (mmol/l * min)

tag: plasma glucose area under the curve above basal (ogtt) (mmol/l * min)

tag: log10 homair (insulin resistance index based on homa)

tag: log10 homais (insulin secretion index based on homa)

tag: log10 insulin area under the curve (ogtt) (pmol/l * min)

tag: insgenin (insulinogenic index)

tag: log10 insulin area under the curve above basal (ogtt) (pmol/l * min)

tag: log10 matsuda insulin sensitivity index

tag: lg10 plasma adiponectin (mg/l)

tag: ogtt fasting plasma free fatty acid (mmol/l)

tag: ogtt 30 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma free fatty acid (mmol/l)

tag: ogtt 120 min plasma insulin (mu/l)

tag: log10 ogtt fasting plasma proinsulin (pm/l)

tag: ogtt 30 min plasma proinsulin (pm/l)

tag: ogtt 120 min plasma proinsulin (pm/l)

tag: log10 bioimpedance

tag: log10 bioimpedance (reactance)

tag: waist to hip ratio

tag: log10 serum bilirubin (umol/l)

tag: log10 serum alanine aminotransfrase (u/l)

tag: log10 creatinine (umol/l)


title: chromosomal forum domains termini 1

status: Public on Mar 31 2013

city: Moscow

first: Nickolai

last: Tchurikov

address: 32, Vavilova str.

department: Department of Epigenetic Mechanisms of Gene Expression Regulation

country: Russia

institute: Engelhardt Institute of Molecular Biology

description:
contains data from chromosomes
Amplicon

library_source: genomic

data_processing: The processing of the raw sff data was the following:  conversion from sff to fasta format was performed by PyroBayes software package (http://bioinformatics.bc.edu/marthlab/PyroBayes), then two primers was cut-off by means of the pair alignment made by FASTA version 34.26.5 (http://faculty.virginia.edu/wrpearson/fasta) with the following parameters "-z 11,12,14,15 -A -E 0.01 -n -m 9 -Q". Then all sequences shorter than 18bp has been removed from the filtered dataset. The final mapping was performed by the bwatools (http://bio-bwa.sourceforge.net) and samtools (http://samtools.sourceforge.net) with the Homo sapiens masked genome (assembly GRCh37/hg19) as the database. Original 357893 reads from two .SFF files were mapped in repeat-masked Human genome (assembly GRCh37p5/hg19, February, 2009), and then aligned into 75794 “clusters”, possessing up to 456 reads each. FT is defined as a cluster containing at least two reads overlapping non less than 0.8 of their length (1+0.8=1.8 threshold; p<0.00019). The sequences corresponding to 75794 mapped clusters are presented in table.txt (linked as supplementary file to Series record). Finally 16535 FT containing at least 2 distinct reads, 0.8 overlapping, were selected. The selected FT produce in sequenced chromosomes the pattern of DNA fragments corresponding to one observed in the pulsed-field gels.These reads are presented in deposited .gff and .wig files split by chromosomes for the convenience. The data that are inside .gff and .wig files are the same, only format differs.

molecule: genomic DNA

source_name: HEK293T cells

growth_protocol: The cells were cultured in Dulbecco’s modified Eagle medium (DMEM) supplemente+B29d with 10% FBS penicillin (100 U/ml), streptomycin (100ug/ml) and L-glutamine (4 mM).

extract_protocol:
Forum domains preparation:
DNA-agarose plugs were prepared as described before [Tchurikov NA and Ponomarenko NA (1992) Detection of DNA domains in Drosophila, human and plant chromosomes possessing mainly 50- to 150-kilobase stretches of DNA. Proc Natl Acad Sci USA 89: 6751-6755]. About 6 millions of HEK293T cells in 2 ml of culture medium were pelleted by centrifugation at 2000 rpm, resuspended in 0.3 ml of the same medium, gently mixed at 42°C with an equal volume of a 1% agarose L (LKB) in PBS solution, and distributed on a mold containing 100-microliters wells. The mold was placed on ice for 2-5 min, covered with parafilm. The agarose plugs were then placed in Petri dishes with 5 ml of solution containing 0.5 M EDTA (pH 9.5), 1% sodium laurylsarcosine, and 1-2 mg of proteinase K solution per ml for 40-48 hr at 50°C, and stored at 4°C in the same solution. Each DNA-agarose plus usually contained about 15 microgramms of DNA corresponding to about 1 millions of cells.
To test the quality of isolated DNA the fractionation in the pulsed-field gels was performed as described before (Tchurikov and Ponomarenko, 1992). Portions of the original agarose-DNA plugs (5-50 microliters) containing 1-10 microgramms of DNA were used for electrophoresis without any restriction enzyme digestion. The DNA samples were run in 0.8% agarose gels on an LKB Pulsaphor system using hexagonal electrode and switching times of 25 or 450 sec.
For elution of DNA preparations the fractionation in 1% agarose conventional mini-gel was performed. One-half of DNA-agarose plug was washed in 1xTE 3 times (for 15 min each) following by 3 times washing in the same solution containing 17.4 microgramms/ml PMSF in ethanol. After fractionation in the mini-gel, the ethidium-bromide stained DNA band was excised and electoeluted inside the dialysis cellulose membrane bag. After overnight dialysis without stirring against 1 liter of 0.01 x TE at 4°C, the DNA was concentrated with PEG (4°C) and redialyzed.
.
Rapid amplification of forum domains termini (RAFT) procedure:
About 1.5 microgramms of isolated DNA (see above) was treated with Klenow fragment and then ligated with 70 ng of double-stranded oligonucleotide (25 bp long 5’-phosphorylated 5’ pCCCCTGCAGTATAAGGAGAATTCGGG 3’ oligonucleotide annealed with 26 bp long 5’ biotinylated 5’ bio-CCGAATTCTCCTTATACTGCAGGGG 3’ oligonucleotide) in 150 microliters of solution containing 0.1 M NaCl, 50 mM Tris HCl (pH 7.4), 8 mM MgCl2, 9 mM 2-mercaptoethanol, 7 microM ATP, 7.5 % PEG, and 40 units of T4 DNA ligase at 20°C for 16 hr. After heating at 65°C for 10 min the DNA preparation was digested with Sau3A enzyme to shorten the forum domain to the termini attached to the ligated oligonicleotide. The selection of such termini was performed in 0.5 ml eppendorf tubes using 300 microliters of suspension containing streptavidin magnespere paramagnetic particles, SA-PMP (Promega) according to the manufacturer's recommendations. After extensive washing with 0.5xSSC removing DNA fragments corresponding to internal parts of forum domains, the forum termini (FT) DNA preparation was eluted from the SA-PMP using digestion with EcoRI enzyme in final volume of 50?mictolitres (double-stranded FT). The FT were then ligated with 100x molar excess of double-stranded Sau3A adaptor (5’-phosphorylated 5’ pGATCGTTTGCGGCCGCTTAAGCTTGGG 3’ oligonucleotide annealed with 5’ CCCAAGCTTAAGCGGCCGCAAAC 3’ oligonucleotide). In some experiments (FT) DNA preparation was eluted from the SA-PMP using heating by incubation at 100°C for 3 min in 50 microliters of 0.01xTE (single-stranded FT). Before heating the FT preparation was ligated with100x molar excess of double-stranded Sau3A adaptor in suspension with SA-PMP (see above). Both final DNA samples (double-stranded FT or single-stranded FT) were used for PCR amplifications. 40 cycle PCR amplification in 30 microlitersl of a solution containing 67 mM Tris-HCl (pH 8.4); 6 mM MgCl2; 10 mM 2-mercaptoethanol; 16.6 mM ammonium sulfate; 6.7 microM EDTA; 5 microg/ml BSA; 1 mM dNTPs; 1 microg of primer corresponding to Sau3A adaptor (5’ CCCAAGCTTAAGCGGCCGCAAAC 3’); 1 microg of primer corresponding to biotinilated oligonucleotide (5’ CCGAATTCTCCTTATACTGCAGGGG 3’) and 1 u of Taq polymerase was performed using Eppendorf Mastercycler Personal. Amplification conditions were 90°C for melting, 65°C for annealing and 72°C for extension, for 1 min each.

treatment_protocol: HEK 293 cells were seeded in 10 cm culture plates 1-2 days before experiment in DMEM containing 10% FBS, and used at approximately 60-80% confluency.

tag: cell line

value: HEK293T cells

tag: passages

value: regular cultured cells


title: chromosomal forum domains termini 2

description:
contains data from chromosomes
Amplicon

data_processing: The processing of the raw sff data was the following:  conversion from sff to fasta format was performed by PyroBayes software package (http://bioinformatics.bc.edu/marthlab/PyroBayes), then two primers was cut-off by means of the pair alignment made by FASTA version 34.26.5 (http://faculty.virginia.edu/wrpearson/fasta) with the following parameters "-z 11,12,14,15 -A -E 0.01 -n -m 9 -Q". Then all sequences shorter than 18bp has been removed from the filtered dataset. The final mapping was performed by the BWA (http://bio-bwa.sourceforge.net) and samtools (http://samtools.sourceforge.net) with the Homo sapiens masked genome (assembly GRCh37/hg19) as the database. Original 357893 reads from two .SFF files were mapped in repeat-masked Human genome (assembly GRCh37p5/hg19, February, 2009), and then aligned into 75794 “clusters”, possessing up to 456 reads each. FT is defined as a cluster containing at least two reads overlapping non less than 0.8 of their length (1+0.8=1.8 threshold; p<0.00019). The sequences corresponding to 75794 mapped clusters are presented in table.txt (linked as supplementary file to Series record). Finally 16535 FT containing at least 2 distinct reads, 0.8 overlapping, were selected. The selected FT produce in sequenced chromosomes the pattern of DNA fragments corresponding to one observed in the pulsed-field gels.These reads are presented in deposited .gff and .wig files split by chromosomes for the convenience. The data that are inside .gff and .wig files are the same, only format differs.

treatment_protocol: HEK 293T cells were seeded in 10 cm culture plates 1-2 days before experiment in DMEM containing 10% FBS, and used at approximately 60-80% confluency.


title: FoxA1 ChIP-seq in Asynchronous Cells 2

city: Philadelphia

first: Kenneth

middle: S.

last: Zaret

state: PA

address: 9-132, SCTR, 3400 Civic Center Boulevard

department: Cell and Developmental Biology

institute: University of Pennsylvania School of Medicine

description: DNA immunoprecipitated by FoxA1

data_processing:
ELAND was used to perform base-calls (default parameters)
Quality control and alignment was performed using ELAND (default parameters)
MACS was used to detect peaks in FoxA1 binding (MFOLD=16, FDR=0.05 for mitotic and 0.0005 for asynchronous cells after pooling replicates
Track views were generated by pooling replicates, then binning all aligned tags into 25bp bins and normalizing by the total number of bases sequenced, then subtracting input
Genome_build: hg18 (NCBI 36)
Supplementary_files_format_and_content: BED6 files are included for called peaks

source_name: HuH7 cells, asynchronously cycling

growth_protocol: HuH7 cells were plated in fresh DMEM High Glucose with L-glutamine (Invitrogen; Carlsbad, CA; 11965) containing 10% FBS (HyClone, Logan, UT) and 1% penicillin-streptomycin (Invitrogen) and grown overnight to 75% confluence.

extract_protocol: Triplicate immunoprecipitation samples were adjusted to 335 µg and then divided into two aliquots.  The incubation with FoxA1 antibodies were performed with 18 µg. ChIP products were used to generate libraries using a ChIP-Seq sample preparation kit (illumina IP-102-1001, San Diego CA).  Amplicons between 100 and 200 bp were validated on a Bioanalyzer (Agilent Technologies 2100, Santa Clara CA) before being used for sequencing on an Illumina Sequencer.

treatment_protocol: Cells were blocked in S phase by addition of fresh medium containing 2 mM thymidine (Sigma; St. Louis, MO; T1895).  After 24 hours, cells were washed three times with PBS and released into medium containing 0.06 µg/mL nocodazole (Sigma; M1404). After 18 h, about 94% of the cells were blocked in metaphase (Fig. S5a) and used for imaging or ChIP. For mitotic block-release studies, arrested cells were either:  1) harvested by gentle shaking and replated into fresh medium, or 2) washed 3 times with PBS (2 minutes incubation at room temperature per wash)  and fresh medium was added to the cells.

tag: cell type

tag: cycling state

value: asynchronous

tag: antibody

tag: vendor/catalog/lot


title: FoxA1 ChIP-seq in Mitotic Cells 1

description: DNA immunoprecipitated by FoxA1

source_name: HuH7 cells, mitotic block and release

value: mitotic


title: FoxA1 ChIP-seq in Mitotic Cells 2

description: DNA immunoprecipitated by FoxA1


title: FoxA1 ChIP-seq in Asynchronous Cells 3

description: DNA immunoprecipitated by FoxA1


title: FoxA1 ChIP-seq in Mitotic Cells 3

description: DNA immunoprecipitated by FoxA1


title: Input in Asynchronous Cells

description: DNA without immunoprecipitation


title: FoxA1 ChIP-seq in Asynchronous Cells 1

description: DNA immunoprecipitated by FoxA1


title: Input in Mitotic Cells

description: DNA without immunoprecipitation