title: Tet-tko-chimera_embryo02_G12_RNAseq


title: E8.5_plate1_B01_BSseq

status: Public on Jul 19 2022

type: SRA

city: Cambridge

first: Felix

last: Krueger

address: Granta Park

department: Bioinformatics

country: United Kingdom

institute: Altos Labs

library_source: genomic

data_processing:
Libraries were sequenced on the Illumina Novaseq platform using the default RTA analysis software.
BS-seq libraries were aligned to the bisuflite converted GRCm38 mouse genome using Bismark (v0.22.1) in single-end non-directional mode. Following the removal of PCR duplicates, we retained a mean of 1.6 million reads per cell. Methylation calling and separation of endogenous methylation (from A-C-G and T-C-G trinucleotides) and chromatin accessibility (G-C-A, G-C-C and G-C-T trinucleotides) was performed with Bismark using the --NOMe option of the coverage2cytosine script.
Following our previous approach, individual CpG or GpC sites in each cell were modelled using a binomial distribution where the number of successes is the number of reads that support methylation and the number of trials is the total number of reads. A CpG methylation or GpC accessibility rate for each site and cell was calculated by maximum likelihood. The rates were subsequently rounded to the nearest integer (0 or 1).
Assembly: GRCm38
Supplementary files format and content: Accessibiliy file  <chromosome><position><methylated_reads><nonmethylated_reads><binary_accessibility_status>
Supplementary files format and content: Methylation file  <chromosome><position><methylated_reads><nonmethylated_reads><binary_methylation_status>

molecule: genomic DNA

organism: Mus musculus

source_name: Early embryo

extract_protocol: Single-cells were sorted using flow cytometry into 96 well PCR plates containing 2.5μl of methylase reaction buffer (1 × M.CviPI Reaction buffer (NEB), 2 U M.CviPI (NEB), 160 μM S-adenosylmethionine (NEB), 1 U μl−1 RNasein (Promega), 0.1% IGEPAL (Sigma)). Samples were incubated for 15 minutes at 37°C to methylate accessible chromatin before the reaction was stopped with the addition of RLT plus buffer (Qiagen) and samples frozen down and stored at -80°C prior to processing. Poly-A RNA was captured on oligo-dT conjugated to magnetic beads and amplified cDNA was prepared according to the G&T-seq and Smartseq2 protocols. The lysate containing gDNA was purified on AMPureXP beads before bisulfite-seq libraries were prepared according to the scBS-seq protocol.

tag: strain

tag: tissue

value: E8.5 embryo


title: Tet-tko-chimera_embryo02_G10_RNAseq

library_source: transcriptomic

data_processing:
Libraries were sequenced on the Illumina Nextseq500 platform using the default RTA analysis software.
RNA-seq libraries were aligned to the GRCm38 mouse genome build using HISAT2 (v2.1.0) using options --dta --no-softclipping --no-mixed --no-discordant, yielding a mean of 611,000 aligned reads per cell.
Subsequently, gene expression counts were quantified from the mapped reads using featureCounts with the Ensembl gene annotation (version 87). Only protein-coding genes matching canonical chromosomes were considered. The read counts were log-transformed and size-factor adjusted.
Assembly: GRCm38
Supplementary files format and content: A table of genes (rows) x cells (columns). The first column is the ensembl gene ID

molecule: total RNA

extract_protocol: Single-cells were sorted  using flow cytometry (E6.5, E7.5) into 96 well PCR plates containing 2.5μl of methylase reaction buffer (1 × M.CviPI Reaction buffer (NEB), 2 U M.CviPI (NEB), 160 μM S-adenosylmethionine (NEB), 1 U μl−1 RNasein (Promega), 0.1% IGEPAL (Sigma)). Samples were incubated for 15 minutes at 37°C to methylate accessible chromatin before the reaction was stopped with the addition of RLT plus buffer (Qiagen) and samples frozen down and stored at -80°C prior to processing. Poly-A RNA was captured on oligo-dT conjugated to magnetic beads and amplified cDNA was prepared according to the G&T-seq and Smartseq2 protocols. The lysate containing gDNA was purified on AMPureXP beads before bisulfite-seq libraries were prepared according to the scBS-seq protocol.

value: E7.5 embryo


title: E8.5_plate1_A11_BSseq


title: Tet-tko-chimera_embryo04_A06_RNAseq


title: Tet-tko-chimera_embryo02_G09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [638160]

type: genomic

city: Granada

first: Guillermo

last: Barturen

state: Andalucia

address: Faculty of Science. Fuente nueva s/n

department: Department of Genetics

country: Spain

institute: University of Granada

hyb_protocol: DNA methylation information was profiled with the Illumina's Infinium MethylationEPIC BeadChip, after sample normalization to 500ng and bisulfite conversion with EZ-96 DNA Methylation Kit, as recommended by the manufacturer.

scan_protocol: Arrays were imaged using BeadArray Reader using standard recommended Illumina scanner setting

data_processing:
Samples and probes were quality controlled by gender prediction agreement (outliers > 5 standard deviations), signal from noise detection p-value < 0.1 and minimum number of beads (>3) that passed the detection p-value. Additionally, sexual chromosomes, cross-reactive probes and probes with overlapping SNPs from dbSNP (v.147)  were discarded. Beta normalized values (Functional normalization implemented in minfi R package)
The B.Methylation.txt contains Average Beta values

label: Cy5 and Cy3

organism: Homo sapiens

source_name: Discovery_MILD_whole Blood

label_protocol: Standard Illumina Protocol

extract_protocol: DNA was extracted from whole blood samples by means of the QIAamp DNA Blood Mini kit and the automatic platform QIAcube Connect. Afterwards, DNA quality was validated and normalized using the NanoDrop 2000c and the Qubit4.

tag: subject status

value: SARS-CoV-2 positive individual

tag: age

tag: gender

value: F

tag: cohort

value: Discovery

tag: disease state

value: MILD

tag: tissue/cell type

value: Whole Blood


title: Tet-tko-chimera_embryo02_G11_RNAseq


title: E8.5_plate1_A10_BSseq


title: Whole blood DNA methylation_Discovery_SEVERE [636711]

source_name: Discovery_SEVERE_whole Blood

value: M

value: SEVERE


title: Tet-tko-chimera_embryo02_G07_RNAseq


title: E8.5_plate1_A09_BSseq


title: Tet-tko-chimera_embryo02_H01_RNAseq


title: E8.5_plate1_B03_BSseq


title: Tet-tko-chimera_embryo02_G06_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [635019]


title: Tet-tko-chimera_embryo02_G05_RNAseq


title: E8.5_plate1_A08_BSseq


title: Tet-tko-chimera_embryo02_G02_RNAseq


title: Tet-tko-chimera_embryo02_G04_RNAseq


title: E8.5_plate1_A07_BSseq


title: Whole blood DNA methylation_Discovery_MILD [633672]


title: Whole blood DNA methylation_Discovery_MILD [638346]


title: E8.5_plate1_A06_BSseq


title: Tet-tko-chimera_embryo02_F12_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [62668]

source_name: Discovery_NEGATIVE_whole Blood

value: SARS-CoV-2 negative individual

value: NEGATIVE


title: Tet-tko-chimera_embryo02_G01_RNAseq


title: E8.5_plate1_A05_BSseq


title: Tet-tko-chimera_embryo02_F10_RNAseq


title: Tet-tko-chimera_embryo02_F11_RNAseq


title: Tet-tko-chimera_embryo02_F09_RNAseq


title: Tet-tko-chimera_embryo02_G08_RNAseq


title: Tet-tko-chimera_embryo02_F08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [625952]


title: E8.5_plate1_A04_BSseq


title: Tet-tko-chimera_embryo02_F07_RNAseq


title: Tet-tko-chimera_embryo02_G03_RNAseq


title: E8.5_plate1_A03_BSseq


title: Whole blood DNA methylation_Discovery_MILD [619461]


title: Tet-tko-chimera_embryo02_F06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [61667]


title: E8.5_plate1_A01_BSseq


title: Tet-tko-chimera_embryo02_F05_RNAseq


title: E8.5_plate1_A02_BSseq


title: Whole blood DNA methylation_Discovery_MILD [616596]


title: Tet-tko-chimera_embryo02_F02_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [62604]


title: Whole blood DNA methylation_Discovery_MILD [616015]


title: Tet-tko-chimera_embryo02_E12_RNAseq


title: plate6_H11_L006_AK16886-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [615556]


title: Tet-tko-chimera_embryo02_E10_RNAseq


title: plate6_H09_L006_AK3910-GC03_RNAseq


title: plate6_H10_L006_AK7505-GC03_RNAseq


title: plate6_H08_L006_AK2870-GC03_RNAseq


title: Tet-tko-chimera_embryo02_F03_RNAseq


title: Tet-tko-chimera_embryo02_E08_RNAseq


title: Tet-tko-chimera_embryo02_E06_RNAseq


title: Tet-tko-chimera_embryo02_F04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [604623]


title: Tet-tko-chimera_embryo02_E04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [602187]


title: Tet-tko-chimera_embryo02_E07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [60303]


title: Tet-tko-chimera_embryo02_E02_RNAseq


title: plate6_H07_L006_AK9176-GC03_RNAseq


title: Tet-tko-chimera_embryo02_F01_RNAseq


title: Tet-tko-chimera_embryo02_D12_RNAseq


title: Tet-tko-chimera_embryo02_E03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [600434]


title: Tet-tko-chimera_embryo02_E01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [60159]


title: Whole blood DNA methylation_Validation_NEGATIVE [598888]

source_name: Validation_NEGATIVE_whole Blood

value: Validation


title: Tet-tko-chimera_embryo02_E09_RNAseq


title: plate6_H12_L006_AK3914-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [606442]


title: Tet-tko-chimera_embryo02_D06_RNAseq


title: Tet-tko-chimera_embryo02_E11_RNAseq


title: Tet-tko-chimera_embryo02_D04_RNAseq


title: plate6_H06_L006_5UDI232-GC03_RNAseq


title: Tet-tko-chimera_embryo02_D02_RNAseq


title: Tet-tko-chimera_embryo02_D11_RNAseq


title: Tet-tko-chimera_embryo02_D10_RNAseq


title: plate6_H01_L006_AK5577-GC03_RNAseq


title: plate6_G12_L006_AK3914-GG01_RNAseq


title: Tet-tko-chimera_embryo02_D01_RNAseq


title: plate6_H04_L006_AK7737-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [592566]


title: Tet-tko-chimera_embryo02_E05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [59690]


title: Whole blood DNA methylation_Discovery_NEGATIVE [597890]


title: Tet-tko-chimera_embryo02_D09_RNAseq


title: plate6_H03_L006_AK10266-GC03_RNAseq


title: Tet-tko-chimera_embryo02_D08_RNAseq


title: plate6_H05_L006_AK9173-GC03_RNAseq


title: plate6_G11_L006_AK16886-GG01_RNAseq


title: Tet-tko-chimera_embryo02_D05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [595253]


title: Tet-tko-chimera_embryo02_C11_RNAseq


title: Tet-tko-chimera_embryo02_C12_RNAseq


title: plate6_G10_L006_AK7505-GG01_RNAseq


title: plate6_H02_L006_7UDI1240-GC03_RNAseq


title: plate6_G09_L006_AK3910-GG01_RNAseq


title: Tet-tko-chimera_embryo02_C08_RNAseq


title: Tet-tko-chimera_embryo02_C06_RNAseq


title: Tet-tko-chimera_embryo02_D07_RNAseq


title: Tet-tko-chimera_embryo02_C07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [592401]


title: Whole blood DNA methylation_Discovery_MILD [585914]


title: Whole blood DNA methylation_Discovery_NEGATIVE [587999]


title: Tet-tko-chimera_embryo02_C03_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [584595]


title: plate6_G06_L006_5UDI232-GG01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [590513]


title: plate6_G08_L006_AK2870-GG01_RNAseq


title: Tet-tko-chimera_embryo02_C01_RNAseq


title: Tet-tko-chimera_embryo02_B12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [575027]


title: Tet-tko-chimera_embryo02_C04_RNAseq


title: plate6_G07_L006_AK9176-GG01_RNAseq


title: Tet-tko-chimera_embryo02_B10_RNAseq


title: Tet-tko-chimera_embryo02_C02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [579052]


title: Tet-tko-chimera_embryo02_C09_RNAseq


title: plate6_G05_L006_AK9173-GG01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [564705]


title: Tet-tko-chimera_embryo02_B11_RNAseq


title: Tet-tko-chimera_embryo02_C05_RNAseq


title: Tet-tko-chimera_embryo02_B09_RNAseq


title: plate6_G03_L006_AK10266-GG01_RNAseq


title: Tet-tko-chimera_embryo02_B07_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [573825]


title: Tet-tko-chimera_embryo02_B08_RNAseq


title: plate6_G01_L006_AK5577-GG01_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [564108]


title: plate6_G02_L006_7UDI1240-GG01_RNAseq


title: Tet-tko-chimera_embryo02_B06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [560971]


title: plate6_G04_L006_AK7737-GG01_RNAseq


title: Tet-tko-chimera_embryo02_B03_RNAseq


title: plate6_F12_L006_AK3914-AK4247_RNAseq


title: Tet-tko-chimera_embryo02_B02_RNAseq


title: Tet-tko-chimera_embryo02_B04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [559653]


title: Tet-tko-chimera_embryo02_B01_RNAseq


title: Tet-tko-chimera_embryo02_A12_RNAseq


title: plate6_F11_L006_AK16886-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [559217]


title: Tet-tko-chimera_embryo02_A10_RNAseq


title: Tet-tko-chimera_embryo02_B05_RNAseq


title: plate6_F10_L006_AK7505-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [55788]


title: Tet-tko-chimera_embryo02_A09_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [557401]


title: plate6_F09_L006_AK3910-AK4247_RNAseq


title: Tet-tko-chimera_embryo02_A06_RNAseq


title: Tet-tko-chimera_embryo02_A07_RNAseq


title: Tet-tko-chimera_embryo02_A08_RNAseq


title: Tet-tko-chimera_embryo02_A05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [551362]


title: Tet-tko-chimera_embryo02_A04_RNAseq


title: plate6_F07_L006_AK9176-AK4247_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [546170]


title: plate6_F06_L006_5UDI232-AK4247_RNAseq


title: Tet-tko-chimera_embryo02_A02_RNAseq


title: Tet-tko-chimera_embryo02_A01_RNAseq


title: Tet-tko-chimera_embryo02_A11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [545629]


title: plate6_F05_L006_AK9173-AK4247_RNAseq


title: Tet-tko-chimera_embryo01_H12_RNAseq


title: Tet-tko-chimera_embryo01_H11_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [544561]


title: Tet-tko-chimera_embryo01_H10_RNAseq


title: plate6_F08_L006_AK2870-AK4247_RNAseq


title: plate6_F04_L006_AK7737-AK4247_RNAseq


title: Tet-tko-chimera_embryo01_H09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [543588]


title: Tet-tko-chimera_embryo01_H08_RNAseq


title: Tet-tko-chimera_embryo01_H07_RNAseq


title: plate6_F03_L006_AK10266-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [541955]


title: Tet-tko-chimera_embryo02_A03_RNAseq


title: Tet-tko-chimera_embryo01_H04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [53805]


title: plate6_F02_L006_7UDI1240-AK4247_RNAseq


title: plate6_F01_L006_AK5577-AK4247_RNAseq


title: Tet-tko-chimera_embryo01_H05_RNAseq


title: Tet-tko-chimera_embryo01_H02_RNAseq


title: Tet-tko-chimera_embryo01_H06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [537650]


title: Tet-tko-chimera_embryo01_H03_RNAseq


title: plate6_E12_L006_AK3914-GG06_RNAseq


title: Tet-tko-chimera_embryo05_C06_RNAseq


title: plate6_E11_L006_AK16886-GG06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [537641]


title: Tet-tko-chimera_embryo01_H01_RNAseq


title: Tet-tko-chimera_embryo01_G09_RNAseq


title: Tet-tko-chimera_embryo01_G11_RNAseq


title: Tet-tko-chimera_embryo01_G10_RNAseq


title: Tet-tko-chimera_embryo01_G12_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [53307]


title: plate6_E10_L006_AK7505-GG06_RNAseq


title: Tet-tko-chimera_embryo01_G08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [533029]


title: plate6_E06_L006_5UDI232-GG06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [530239]


title: plate6_E08_L006_AK2870-GG06_RNAseq


title: plate6_E05_L006_AK9173-GG06_RNAseq


title: plate6_E09_L006_AK3910-GG06_RNAseq


title: Tet-tko-chimera_embryo01_G03_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [531194]


title: Tet-tko-chimera_embryo01_F11_RNAseq


title: Tet-tko-chimera_embryo01_F10_RNAseq


title: Tet-tko-chimera_embryo01_F08_RNAseq


title: Tet-tko-chimera_embryo01_G05_RNAseq


title: Tet-tko-chimera_embryo01_G07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [531154]


title: Tet-tko-chimera_embryo01_G04_RNAseq


title: Tet-tko-chimera_embryo01_F07_RNAseq


title: plate6_E07_L006_AK9176-GG06_RNAseq


title: Tet-tko-chimera_embryo01_G02_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [53017]


title: Whole blood DNA methylation_Validation_NEGATIVE [525490]


title: Tet-tko-chimera_embryo01_F06_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [526083]


title: plate6_E04_L006_AK7737-GG06_RNAseq


title: Tet-tko-chimera_embryo01_G06_RNAseq


title: Tet-tko-chimera_embryo01_F05_RNAseq


title: Tet-tko-chimera_embryo01_F09_RNAseq


title: plate6_E03_L006_AK10266-GG06_RNAseq


title: Tet-tko-chimera_embryo01_G01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [528810]


title: Tet-tko-chimera_embryo01_F12_RNAseq


title: Tet-tko-chimera_embryo01_F01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [519991]


title: Tet-tko-chimera_embryo01_E12_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [519924]


title: plate6_E02_L006_7UDI1240-GG06_RNAseq


title: plate6_D11_L006_AK16886-AK4246_RNAseq


title: Tet-tko-chimera_embryo02_D03_RNAseq


title: Tet-tko-chimera_embryo01_E10_RNAseq


title: Tet-tko-chimera_embryo01_E11_RNAseq


title: Tet-tko-chimera_embryo01_E09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [524165]


title: plate6_D10_L006_AK7505-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_E07_RNAseq


title: Tet-tko-chimera_embryo01_E08_RNAseq


title: Tet-tko-chimera_embryo01_F04_RNAseq


title: plate6_E01_L006_AK5577-GG06_RNAseq


title: Tet-tko-chimera_embryo02_C10_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [519360]


title: plate6_D08_L006_AK2870-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_F02_RNAseq


title: plate6_D12_L006_AK3914-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_E06_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [517418]


title: plate6_D09_L006_AK3910-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_E05_RNAseq


title: plate6_D07_L006_AK9176-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_E04_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [521686]


title: plate6_D05_L006_AK9173-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_E03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [514751]


title: plate6_D06_L006_5UDI232-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_D12_RNAseq


title: Tet-tko-chimera_embryo01_D11_RNAseq


title: Tet-tko-chimera_embryo01_E01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [517266]


title: Tet-tko-chimera_embryo01_D10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [51420]


title: Tet-tko-chimera_embryo01_D09_RNAseq


title: plate6_D03_L006_AK10266-AK4246_RNAseq


title: plate6_D04_L006_AK7737-AK4246_RNAseq


title: Tet-tko-chimera_embryo01_D07_RNAseq


title: Tet-tko-chimera_embryo01_D08_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [512889]


title: plate6_D02_L006_7UDI1240-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [518483]


title: Whole blood DNA methylation_Discovery_NEGATIVE [512642]


title: Tet-tko-chimera_embryo01_D06_RNAseq


title: Tet-tko-chimera_embryo01_D05_RNAseq


title: Tet-tko-chimera_embryo01_D04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [512103]


title: plate6_D01_L006_AK5577-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [516524]


title: plate6_C12_L006_AK3914-AK4245_RNAseq


title: plate6_C11_L006_AK16886-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [509468]


title: Tet-tko-chimera_embryo01_D02_RNAseq


title: plate6_C10_L006_AK7505-AK4245_RNAseq


title: Tet-tko-chimera_embryo01_C11_RNAseq


title: Tet-tko-chimera_embryo01_C12_RNAseq


title: Tet-tko-chimera_embryo01_C09_RNAseq


title: plate6_C09_L006_AK3910-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [50194]


title: Whole blood DNA methylation_Discovery_MILD [502112]


title: plate6_C08_L006_AK2870-AK4245_RNAseq


title: Tet-tko-chimera_embryo01_C08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [501575]


title: Tet-tko-chimera_embryo01_C06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [501280]


title: Tet-tko-chimera_embryo01_C04_RNAseq


title: Tet-tko-chimera_embryo01_C03_RNAseq


title: Tet-tko-chimera_embryo01_C05_RNAseq


title: Tet-tko-chimera_embryo01_C02_RNAseq


title: Tet-tko-chimera_embryo01_C10_RNAseq


title: Tet-tko-chimera_embryo01_D03_RNAseq


title: Tet-tko-chimera_embryo01_C01_RNAseq


title: plate6_C06_L006_5UDI232-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [50120]


title: Tet-tko-chimera_embryo01_D01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [500776]


title: Tet-tko-chimera_embryo01_B12_RNAseq


title: plate6_C07_L006_AK9176-AK4245_RNAseq


title: plate6_C04_L006_AK7737-AK4245_RNAseq


title: plate6_C05_L006_AK9173-AK4245_RNAseq


title: Tet-tko-chimera_embryo01_B11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [50077]


title: Tet-tko-chimera_embryo01_C07_RNAseq


title: Tet-tko-chimera_embryo01_B09_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [495902]


title: Tet-tko-chimera_embryo01_B08_RNAseq


title: Tet-tko-chimera_embryo01_B06_RNAseq


title: Tet-tko-chimera_embryo01_B07_RNAseq


title: plate6_C02_L006_7UDI1240-AK4245_RNAseq


title: plate6_B12_L006_AK3914-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [495426]


title: plate6_C01_L006_AK5577-AK4245_RNAseq


title: Tet-tko-chimera_embryo01_B04_RNAseq


title: Tet-tko-chimera_embryo01_B02_RNAseq


title: Tet-tko-chimera_embryo01_B03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [493676]


title: Tet-tko-chimera_embryo01_B10_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [489651]


title: Tet-tko-chimera_embryo01_A12_RNAseq


title: plate6_C03_L006_AK10266-AK4245_RNAseq


title: plate6_B11_L006_AK16886-AK4244_RNAseq


title: Tet-tko-chimera_embryo01_A09_RNAseq


title: Tet-tko-chimera_embryo01_A10_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [496850]


title: Whole blood DNA methylation_Discovery_MILD [488905]


title: Whole blood DNA methylation_Discovery_MILD [488566]


title: Tet-tko-chimera_embryo01_A08_RNAseq


title: Tet-tko-chimera_embryo01_A07_RNAseq


title: Tet-tko-chimera_embryo01_A11_RNAseq


title: Tet-tko-chimera_embryo01_B05_RNAseq


title: plate6_B09_L006_AK3910-AK4244_RNAseq


title: Tet-tko-chimera_embryo01_A06_RNAseq


title: Tet-tko-chimera_embryo01_B01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [486763]


title: Tet-tko-chimera_embryo01_A05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [486705]


title: Tet-tko-chimera_embryo01_A04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [485654]


title: plate6_B10_L006_AK7505-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [484433]


title: Tet-tko-chimera_embryo01_A02_RNAseq


title: Tet-tko-chimera_embryo01_A01_RNAseq


title: plate6_B06_L006_5UDI232-AK4244_RNAseq


title: plate6_B05_L006_AK9173-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [48267]


title: plate6_B04_L006_AK7737-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [482513]


title: E8.5_plate8_H12_RNAseq


title: E8.5_plate8_H08_RNAseq


title: E8.5_plate8_H11_RNAseq


title: E8.5_plate8_H09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [481652]


title: Tet-tko-chimera_embryo01_F03_RNAseq


title: Tet-tko-chimera_embryo01_A03_RNAseq


title: E8.5_plate8_H06_RNAseq


title: plate6_B08_L006_AK2870-AK4244_RNAseq


title: E8.5_plate8_H05_RNAseq


title: E8.5_plate8_H04_RNAseq


title: plate6_B07_L006_AK9176-AK4244_RNAseq


title: E8.5_plate8_H10_RNAseq


title: E8.5_plate8_H03_RNAseq


title: plate6_B01_L006_AK5577-AK4244_RNAseq


title: plate6_B02_L006_7UDI1240-AK4244_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [481223]


title: plate6_A12_L006_AK3914-GC07_RNAseq


title: E8.5_plate8_H01_RNAseq


title: E8.5_plate8_H02_RNAseq


title: E8.5_plate8_H07_RNAseq


title: E8.5_plate8_G12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [479697]


title: E8.5_plate8_G11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [479135]


title: E8.5_plate8_G10_RNAseq


title: plate6_A11_L006_AK16886-GC07_RNAseq


title: E8.5_plate8_G09_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [479071]


title: plate6_A10_L006_AK7505-GC07_RNAseq


title: E8.5_plate8_G08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [478662]


title: plate6_A09_L006_AK3910-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [478537]


title: plate6_A08_L006_AK2870-GC07_RNAseq


title: E8.5_plate8_G07_RNAseq


title: E8.5_plate8_G04_RNAseq


title: E8.5_plate8_G05_RNAseq


title: plate6_A07_L006_AK9176-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [476762]


title: E8.5_plate8_G02_RNAseq


title: E8.5_plate8_G01_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [474620]


title: plate6_A05_L006_AK9173-GC07_RNAseq


title: E8.5_plate8_F12_RNAseq


title: plate6_A04_L006_AK7737-GC07_RNAseq


title: E8.5_plate8_F10_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [474099]


title: E8.5_plate8_F11_RNAseq


title: E8.5_plate8_F09_RNAseq


title: E8.5_plate8_G06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [473936]


title: E8.5_plate8_F07_RNAseq


title: E8.5_plate8_F08_RNAseq


title: E8.5_plate8_F06_RNAseq


title: E8.5_plate8_F05_RNAseq


title: plate6_A03_L006_AK10266-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [473038]


title: Whole blood DNA methylation_Validation_NEGATIVE [481280]


title: E8.5_plate8_G03_RNAseq


title: plate6_A02_L006_7UDI1240-GC07_RNAseq


title: E8.5_plate8_F04_RNAseq


title: plate6_A01_L006_AK5577-GC07_RNAseq


title: E8.5_plate8_F03_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [476334]


title: plate6_A06_L006_5UDI232-GC07_RNAseq


title: E8.5_plate8_F01_RNAseq


title: plate5_H12_L005_AK6249-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [472216]


title: E8.5_plate8_F02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [470177]


title: E8.5_plate8_E11_RNAseq


title: plate5_H11_L005_AK9170-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [469186]


title: E8.5_plate8_E10_RNAseq


title: plate5_H10_L005_AK9404-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [46244]


title: E8.5_plate8_E08_RNAseq


title: E8.5_plate8_E12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [461989]


title: Tet-tko-chimera_embryo01_E02_RNAseq


title: E8.5_plate8_E07_RNAseq


title: E8.5_plate8_E09_RNAseq


title: plate5_H09_L005_AK6296-GC03_RNAseq


title: E8.5_plate8_E06_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [455852]


title: E8.5_plate8_E04_RNAseq


title: E8.5_plate8_E02_RNAseq


title: E8.5_plate8_E03_RNAseq


title: plate5_H07_L005_AK8571-GC03_RNAseq


title: E8.5_plate8_E01_RNAseq


title: plate5_H08_L005_AK7085-GC03_RNAseq


title: plate5_H06_L005_AK763-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [453688]


title: plate5_H05_L005_5UDI219-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [453262]


title: E8.5_plate8_D12_RNAseq


title: plate5_H04_L005_AK840-GC03_RNAseq


title: E8.5_plate8_D11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [45261]


title: E8.5_plate8_D08_RNAseq


title: plate5_H03_L005_5UDI265-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [452065]


title: Whole blood DNA methylation_Discovery_MILD [461518]


title: E8.5_plate8_D10_RNAseq


title: plate5_H02_L005_AK5426-GC03_RNAseq


title: E8.5_plate8_E05_RNAseq


title: E8.5_plate8_D06_RNAseq


title: E8.5_plate8_D05_RNAseq


title: E8.5_plate8_D04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [438972]


title: E8.5_plate8_D01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [438661]


title: plate5_G12_L005_AK6249-GG01_RNAseq


title: E8.5_plate8_C12_RNAseq


title: E8.5_plate8_D02_RNAseq


title: E8.5_plate8_D03_RNAseq


title: E8.5_plate8_C11_RNAseq


title: plate5_G11_L005_AK9170-GG01_RNAseq


title: E8.5_plate8_C09_RNAseq


title: E8.5_plate8_D09_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [430909]


title: E8.5_plate8_C10_RNAseq


title: plate5_G09_L005_AK6296-GG01_RNAseq


title: plate5_G08_L005_AK7085-GG01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [432426]


title: Whole blood DNA methylation_Discovery_NEGATIVE [438159]


title: E8.5_plate8_C03_RNAseq


title: E8.5_plate8_C04_RNAseq


title: plate5_G10_L005_AK9404-GG01_RNAseq


title: E8.5_plate8_C08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [445532]


title: Whole blood DNA methylation_Discovery_MILD [424676]


title: E8.5_plate8_C07_RNAseq


title: plate5_G07_L005_AK8571-GG01_RNAseq


title: E8.5_plate8_C01_RNAseq


title: E8.5_plate8_C06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [430499]


title: plate5_H01_L005_AK2831-GC03_RNAseq


title: plate5_G05_L005_5UDI219-GG01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [422345]


title: E8.5_plate8_C02_RNAseq


title: plate5_G06_L005_AK763-GG01_RNAseq


title: E8.5_plate8_B10_RNAseq


title: E8.5_plate8_B12_RNAseq


title: plate5_G04_L005_AK840-GG01_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [421823]


title: Whole blood DNA methylation_Discovery_MILD [421766]


title: E8.5_plate8_B08_RNAseq


title: E8.5_plate8_B09_RNAseq


title: plate5_G03_L005_5UDI265-GG01_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [421579]


title: E8.5_plate8_B11_RNAseq


title: E8.5_plate8_B07_RNAseq


title: plate5_G01_L005_AK2831-GG01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [420765]


title: E8.5_plate8_B06_RNAseq


title: E8.5_plate8_B03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [417195]


title: plate5_G02_L005_AK5426-GG01_RNAseq


title: E8.5_plate8_B02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [42003]


title: plate5_F12_L005_AK6249-AK4247_RNAseq


title: E8.5_plate8_A12_RNAseq


title: E8.5_plate8_B05_RNAseq


title: E8.5_plate8_B04_RNAseq


title: E8.5_plate8_A11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [415235]


title: plate6_B03_L006_AK10266-AK4244_RNAseq


title: plate5_F10_L005_AK9404-AK4247_RNAseq


title: plate5_F11_L005_AK9170-AK4247_RNAseq


title: E8.5_plate8_A10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [413312]


title: E8.5_plate8_A08_RNAseq


title: plate5_F09_L005_AK6296-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [411305]


title: E8.5_plate8_A06_RNAseq


title: E8.5_plate8_A07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [411073]


title: E8.5_plate8_A05_RNAseq


title: plate5_F08_L005_AK7085-AK4247_RNAseq


title: E8.5_plate8_A04_RNAseq


title: E8.5_plate8_A02_RNAseq


title: E8.5_plate8_A03_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [407790]


title: plate5_F07_L005_AK8571-AK4247_RNAseq


title: E8.5_plate8_A01_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [408871]


title: plate5_F06_L005_AK763-AK4247_RNAseq


title: E8.5_plate7_H10_RNAseq


title: E8.5_plate7_H12_RNAseq


title: E8.5_plate8_D07_RNAseq


title: E8.5_plate8_A09_RNAseq


title: E8.5_plate7_H11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [405021]


title: plate5_F04_L005_AK840-AK4247_RNAseq


title: plate5_F05_L005_5UDI219-AK4247_RNAseq


title: E8.5_plate7_H09_RNAseq


title: E8.5_plate7_H08_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [397233]


title: plate5_F01_L005_AK2831-AK4247_RNAseq


title: E8.5_plate7_H07_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [39995]


title: plate5_F03_L005_5UDI265-AK4247_RNAseq


title: E8.5_plate7_H02_RNAseq


title: E8.5_plate7_H01_RNAseq


title: E8.5_plate7_G12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [383622]


title: Whole blood DNA methylation_Discovery_SEVERE [390239]


title: E8.5_plate7_H05_RNAseq


title: plate5_E10_L005_AK9404-GG06_RNAseq


title: E8.5_plate7_G09_RNAseq


title: E8.5_plate7_H06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [403230]


title: Whole blood DNA methylation_Discovery_MILD [383038]


title: plate5_F02_L005_AK5426-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [393862]


title: E8.5_plate7_G11_RNAseq


title: plate5_E11_L005_AK9170-GG06_RNAseq


title: E8.5_plate7_G10_RNAseq


title: E8.5_plate7_G06_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [379948]


title: E8.5_plate7_G08_RNAseq


title: plate5_E08_L005_AK7085-GG06_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [378279]


title: E8.5_plate7_G02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [37372]


title: E8.5_plate7_H04_RNAseq


title: E8.5_plate7_F12_RNAseq


title: plate5_E05_L005_5UDI219-GG06_RNAseq


title: E8.5_plate7_F11_RNAseq


title: plate5_E09_L005_AK6296-GG06_RNAseq


title: E8.5_plate7_G07_RNAseq


title: E8.5_plate7_G04_RNAseq


title: E8.5_plate7_G05_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [373059]


title: Whole blood DNA methylation_Discovery_SEVERE [378757]


title: E8.5_plate7_F07_RNAseq


title: E8.5_plate7_G03_RNAseq


title: plate5_E07_L005_AK8571-GG06_RNAseq


title: E8.5_plate7_F06_RNAseq


title: plate5_E06_L005_AK763-GG06_RNAseq


title: E8.5_plate7_G01_RNAseq


title: E8.5_plate8_B01_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [369299]


title: E8.5_plate7_F10_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [373343]


title: E8.5_plate8_C05_RNAseq


title: plate5_E03_L005_5UDI265-GG06_RNAseq


title: E8.5_plate7_F02_RNAseq


title: plate5_E04_L005_AK840-GG06_RNAseq


title: E8.5_plate7_F09_RNAseq


title: E8.5_plate7_F05_RNAseq


title: plate5_E02_L005_AK5426-GG06_RNAseq


title: E8.5_plate7_F08_RNAseq


title: E8.5_plate7_F04_RNAseq


title: E8.5_plate7_E12_RNAseq


title: plate5_E01_L005_AK2831-GG06_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [369546]


title: E8.5_plate7_H03_RNAseq


title: plate5_D12_L005_AK6249-AK4246_RNAseq


title: E8.5_plate7_F01_RNAseq


title: E8.5_plate7_E10_RNAseq


title: plate5_D11_L005_AK9170-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [366206]


title: Whole blood DNA methylation_Validation_NEGATIVE [365080]


title: E8.5_plate7_F03_RNAseq


title: plate5_D09_L005_AK6296-AK4246_RNAseq


title: E8.5_plate7_E09_RNAseq


title: plate5_D10_L005_AK9404-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [360387]


title: E8.5_plate7_E08_RNAseq


title: E8.5_plate7_E07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [365547]


title: E8.5_plate7_E06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [356012]


title: E8.5_plate7_E05_RNAseq


title: E8.5_plate7_E03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [355723]


title: plate5_D08_L005_AK7085-AK4246_RNAseq


title: E8.5_plate7_E04_RNAseq


title: E8.5_plate7_D11_RNAseq


title: E8.5_plate7_D12_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [354382]


title: E8.5_plate7_E02_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [353165]


title: E8.5_plate7_D10_RNAseq


title: E8.5_plate7_E01_RNAseq


title: E8.5_plate7_D09_RNAseq


title: E8.5_plate7_E11_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [35301]


title: plate5_D04_L005_AK840-AK4246_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [352957]


title: plate5_D03_L005_5UDI265-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [359070]


title: E8.5_plate7_D07_RNAseq


title: E8.5_plate7_D06_RNAseq


title: E8.5_plate7_D08_RNAseq


title: plate5_D07_L005_AK8571-AK4246_RNAseq


title: E8.5_plate7_D05_RNAseq


title: plate5_D06_L005_AK763-AK4246_RNAseq


title: plate5_D02_L005_AK5426-AK4246_RNAseq


title: plate5_D05_L005_5UDI219-AK4246_RNAseq


title: plate5_D01_L005_AK2831-AK4246_RNAseq


title: E8.5_plate7_D03_RNAseq


title: E8.5_plate7_C12_RNAseq


title: plate5_C12_L005_AK6249-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [351078]


title: plate5_E12_L005_AK6249-GG06_RNAseq


title: E8.5_plate7_D01_RNAseq


title: plate5_C11_L005_AK9170-AK4245_RNAseq


title: E8.5_plate7_D02_RNAseq


title: E8.5_plate7_C11_RNAseq


title: E8.5_plate7_C09_RNAseq


title: plate5_C10_L005_AK9404-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [345627]


title: Whole blood DNA methylation_Discovery_MILD [352864]


title: E8.5_plate7_D04_RNAseq


title: E8.5_plate7_C10_RNAseq


title: E8.5_plate7_C08_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [342321]


title: plate5_C08_L005_AK7085-AK4245_RNAseq


title: E8.5_plate7_C06_RNAseq


title: plate5_C07_L005_AK8571-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [339710]


title: E8.5_plate7_C07_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [349314]


title: Whole blood DNA methylation_Discovery_MILD [336322]


title: E8.5_plate7_C05_RNAseq


title: plate5_C06_L005_AK763-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [339206]


title: E8.5_plate7_C04_RNAseq


title: E8.5_plate7_B12_RNAseq


title: E8.5_plate7_C01_RNAseq


title: E8.5_plate7_C02_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [334877]


title: plate5_C09_L005_AK6296-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [332364]


title: plate5_C05_L005_5UDI219-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [330234]


title: E8.5_plate7_C03_RNAseq


title: E8.5_plate7_B11_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [326995]


title: E8.5_plate7_B08_RNAseq


title: E8.5_plate7_B06_RNAseq


title: E8.5_plate7_B07_RNAseq


title: plate5_C02_L005_AK5426-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [329383]


title: plate5_B12_L005_AK6249-AK4244_RNAseq


title: E8.5_plate7_B05_RNAseq


title: E8.5_plate7_B01_RNAseq


title: plate5_C03_L005_5UDI265-AK4245_RNAseq


title: E8.5_plate7_B04_RNAseq


title: plate5_C01_L005_AK2831-AK4245_RNAseq


title: E8.5_plate7_B09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [326757]


title: E8.5_plate7_A12_RNAseq


title: E8.5_plate7_B03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [325016]


title: plate5_C04_L005_AK840-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [326021]


title: E8.5_plate7_B02_RNAseq


title: plate5_B11_L005_AK9170-AK4244_RNAseq


title: plate5_B09_L005_AK6296-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [323932]


title: E8.5_plate7_B10_RNAseq


title: E8.5_plate7_A11_RNAseq


title: E8.5_plate7_A09_RNAseq


title: E8.5_plate7_A08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [322654]


title: E8.5_plate7_A03_RNAseq


title: E8.5_plate7_A06_RNAseq


title: plate5_B07_L005_AK8571-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [320152]


title: E8.5_plate7_A02_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [322874]


title: plate5_B04_L005_AK840-AK4244_RNAseq


title: E8.5_plate6_H10_RNAseq


title: E8.5_plate7_A05_RNAseq


title: E8.5_plate7_A04_RNAseq


title: plate5_B10_L005_AK9404-AK4244_RNAseq


title: E8.5_plate7_A01_RNAseq


title: plate5_B06_L005_AK763-AK4244_RNAseq


title: plate5_B05_L005_5UDI219-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [320497]


title: E8.5_plate6_H12_RNAseq


title: E8.5_plate6_H07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [317594]


title: E8.5_plate6_H11_RNAseq


title: plate5_B08_L005_AK7085-AK4244_RNAseq


title: E8.5_plate7_A10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [319495]


title: E8.5_plate7_A07_RNAseq


title: E8.5_plate6_H09_RNAseq


title: E8.5_plate6_H08_RNAseq


title: plate5_B03_L005_5UDI265-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [314377]


title: Whole blood DNA methylation_Discovery_MILD [317200]


title: E8.5_plate6_H06_RNAseq


title: E8.5_plate6_H01_RNAseq


title: plate5_B02_L005_AK5426-AK4244_RNAseq


title: E8.5_plate6_G11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [316393]


title: E8.5_plate6_H05_RNAseq


title: E8.5_plate6_H04_RNAseq


title: plate5_B01_L005_AK2831-AK4244_RNAseq


title: E8.5_plate6_H02_RNAseq


title: E8.5_plate6_H03_RNAseq


title: plate5_A12_L005_AK6249-GC07_RNAseq


title: E8.5_plate6_G09_RNAseq


title: plate5_A09_L005_AK6296-GC07_RNAseq


title: E8.5_plate6_G03_RNAseq


title: E8.5_plate6_G04_RNAseq


title: plate5_A11_L005_AK9170-GC07_RNAseq


title: E8.5_plate6_G12_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [312966]


title: Whole blood DNA methylation_Validation_NEGATIVE [306518]


title: Whole blood DNA methylation_Discovery_MILD [312547]


title: E8.5_plate6_G10_RNAseq


title: plate5_A06_L005_AK763-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [309354]


title: Whole blood DNA methylation_Discovery_MILD [307701]


title: E8.5_plate6_G08_RNAseq


title: E8.5_plate6_G07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [301334]


title: E8.5_plate6_G06_RNAseq


title: plate5_A05_L005_5UDI219-GC07_RNAseq


title: plate5_A08_L005_AK7085-GC07_RNAseq


title: E8.5_plate6_G05_RNAseq


title: E8.5_plate6_F11_RNAseq


title: plate5_A04_L005_AK840-GC07_RNAseq


title: plate5_A07_L005_AK8571-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [302793]


title: Whole blood DNA methylation_Discovery_MILD [300119]


title: E8.5_plate6_F07_RNAseq


title: plate5_A03_L005_5UDI265-GC07_RNAseq


title: E8.5_plate6_F06_RNAseq


title: E8.5_plate6_F08_RNAseq


title: plate5_A02_L005_AK5426-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [299240]


title: E8.5_plate6_F04_RNAseq


title: E8.5_plate6_F12_RNAseq


title: plate5_A10_L005_AK9404-GC07_RNAseq


title: E8.5_plate6_F03_RNAseq


title: E8.5_plate6_G01_RNAseq


title: plate5_A01_L005_AK2831-GC07_RNAseq


title: E8.5_plate6_F10_RNAseq


title: E8.5_plate6_F09_RNAseq


title: plate4_H11_L004_AK9170-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [299847]


title: E8.5_plate6_E10_RNAseq


title: E8.5_plate6_E08_RNAseq


title: E8.5_plate6_E09_RNAseq


title: E8.5_plate6_F05_RNAseq


title: plate4_H09_L004_AK6296-AK4243_RNAseq


title: E8.5_plate6_F01_RNAseq


title: plate4_H12_L004_AK6249-AK4243_RNAseq


title: E8.5_plate6_E11_RNAseq


title: E8.5_plate6_F02_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [301168]


title: Whole blood DNA methylation_Discovery_MILD [29636]


title: E8.5_plate6_E12_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [297432]


title: Whole blood DNA methylation_Discovery_MILD [298723]


title: Whole blood DNA methylation_Discovery_NEGATIVE [299107]


title: E8.5_plate6_E04_RNAseq


title: plate4_H07_L004_AK8571-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [295374]


title: plate4_H10_L004_AK9404-AK4243_RNAseq


title: E8.5_plate6_E07_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [296032]


title: plate4_H06_L004_AK763-AK4243_RNAseq


title: E8.5_plate6_E03_RNAseq


title: E8.5_plate6_E06_RNAseq


title: plate4_H08_L004_AK7085-AK4243_RNAseq


title: E8.5_plate6_G02_RNAseq


title: E8.5_plate6_E05_RNAseq


title: E8.5_plate6_E01_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [295004]


title: plate4_H05_L004_5UDI219-AK4243_RNAseq


title: E8.5_plate6_E02_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [294013]


title: Whole blood DNA methylation_Discovery_MILD [293045]


title: E8.5_plate6_D11_RNAseq


title: E8.5_plate6_D09_RNAseq


title: plate4_H03_L004_5UDI265-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [292970]


title: plate4_H02_L004_AK5426-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [290940]


title: E8.5_plate6_D08_RNAseq


title: E8.5_plate6_D06_RNAseq


title: E8.5_plate6_D05_RNAseq


title: E8.5_plate6_D04_RNAseq


title: E8.5_plate6_D07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [289495]


title: E8.5_plate6_D02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [288936]


title: plate4_H01_L004_AK2831-AK4243_RNAseq


title: plate4_G12_L004_AK6249-AK903_RNAseq


title: E8.5_plate6_D03_RNAseq


title: E8.5_plate6_D01_RNAseq


title: E8.5_plate6_D12_RNAseq


title: E8.5_plate6_D10_RNAseq


title: plate4_G11_L004_AK9170-AK903_RNAseq


title: E8.5_plate6_C12_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [2874]


title: plate4_H04_L004_AK840-AK4243_RNAseq


title: plate4_G10_L004_AK9404-AK903_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [286938]


title: E8.5_plate6_C11_RNAseq


title: E8.5_plate6_C10_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [286186]


title: E8.5_plate6_C09_RNAseq


title: E8.5_plate6_C08_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [283200]


title: E8.5_plate6_C05_RNAseq


title: E8.5_plate6_C04_RNAseq


title: plate4_G09_L004_AK6296-AK903_RNAseq


title: plate4_G08_L004_AK7085-AK903_RNAseq


title: plate4_G07_L004_AK8571-AK903_RNAseq


title: E8.5_plate6_C07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [279168]


title: E8.5_plate6_C03_RNAseq


title: plate4_G06_L004_AK763-AK903_RNAseq


title: E8.5_plate6_C06_RNAseq


title: E8.5_plate6_C02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [278423]


title: E8.5_plate6_C01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [277524]


title: E8.5_plate6_B12_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [276843]


title: E8.5_plate6_B11_RNAseq


title: plate4_G03_L004_5UDI265-AK903_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [276298]


title: plate4_G04_L004_AK840-AK903_RNAseq


title: E8.5_plate6_B10_RNAseq


title: E8.5_plate6_B08_RNAseq


title: E8.5_plate6_B07_RNAseq


title: E8.5_plate6_B06_RNAseq


title: E8.5_plate6_B05_RNAseq


title: plate4_G02_L004_AK5426-AK903_RNAseq


title: E8.5_plate6_B04_RNAseq


title: E8.5_plate6_B03_RNAseq


title: plate4_G01_L004_AK2831-AK903_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [274912]


title: plate4_G05_L004_5UDI219-AK903_RNAseq


title: plate4_F12_L004_AK6249-GH10_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [273424]


title: E8.5_plate6_B02_RNAseq


title: plate4_F11_L004_AK9170-GH10_RNAseq


title: E8.5_plate6_A12_RNAseq


title: E8.5_plate6_A11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [273258]


title: Whole blood DNA methylation_Discovery_MILD [275927]


title: plate4_F10_L004_AK9404-GH10_RNAseq


title: E8.5_plate6_B09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [271446]


title: E8.5_plate6_A08_RNAseq


title: plate4_F09_L004_AK6296-GH10_RNAseq


title: E8.5_plate6_A07_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [268609]


title: Whole blood DNA methylation_Discovery_MILD [275489]


title: E8.5_plate6_A06_RNAseq


title: E8.5_plate6_A05_RNAseq


title: plate4_F08_L004_AK7085-GH10_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [268302]


title: E8.5_plate6_A04_RNAseq


title: plate4_F07_L004_AK8571-GH10_RNAseq


title: E8.5_plate6_A03_RNAseq


title: E8.5_plate6_B01_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [267812]


title: Whole blood DNA methylation_Discovery_MILD [267780]


title: plate4_F06_L004_AK763-GH10_RNAseq


title: E8.5_plate6_A01_RNAseq


title: E8.5_plate6_A02_RNAseq


title: E8.5_plate6_A10_RNAseq


title: E8.5_plate5_H12_RNAseq


title: E8.5_plate6_A09_RNAseq


title: plate4_F05_L004_5UDI219-GH10_RNAseq


title: plate4_F04_L004_AK840-GH10_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [267600]


title: E8.5_plate5_H10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [265306]


title: E8.5_plate5_H09_RNAseq


title: E8.5_plate5_H08_RNAseq


title: E8.5_plate5_H07_RNAseq


title: plate4_F03_L004_5UDI265-GH10_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [265068]


title: E8.5_plate5_H06_RNAseq


title: E8.5_plate5_H05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [264308]


title: E8.5_plate5_H03_RNAseq


title: E8.5_plate5_H04_RNAseq


title: plate4_F02_L004_AK5426-GH10_RNAseq


title: plate4_F01_L004_AK2831-GH10_RNAseq


title: E8.5_plate5_H02_RNAseq


title: E8.5_plate5_H01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [263210]


title: plate4_E12_L004_AK6249-AK4242_RNAseq


title: E8.5_plate5_G12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [262929]


title: plate4_E10_L004_AK9404-AK4242_RNAseq


title: E8.5_plate5_H11_RNAseq


title: E8.5_plate5_G09_RNAseq


title: E8.5_plate5_G10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [264880]


title: Whole blood DNA methylation_Discovery_MILD [254805]


title: plate4_E09_L004_AK6296-AK4242_RNAseq


title: plate4_E08_L004_AK7085-AK4242_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [256278]


title: E8.5_plate5_G06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [253859]


title: E8.5_plate5_G03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [253675]


title: E8.5_plate5_G05_RNAseq


title: plate4_E07_L004_AK8571-AK4242_RNAseq


title: plate4_E05_L004_5UDI219-AK4242_RNAseq


title: E8.5_plate5_G11_RNAseq


title: plate4_E06_L004_AK763-AK4242_RNAseq


title: plate4_E04_L004_AK840-AK4242_RNAseq


title: plate4_E11_L004_AK9170-AK4242_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [253372]


title: E8.5_plate5_G07_RNAseq


title: E8.5_plate5_F09_RNAseq


title: E8.5_plate5_G01_RNAseq


title: E8.5_plate5_F08_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [252925]


title: E8.5_plate5_F10_RNAseq


title: E8.5_plate5_F11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [252666]


title: Whole blood DNA methylation_Discovery_MILD [253801]


title: plate4_E03_L004_5UDI265-AK4242_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [252473]


title: plate4_E01_L004_AK2831-AK4242_RNAseq


title: plate4_E02_L004_AK5426-AK4242_RNAseq


title: E8.5_plate5_F02_RNAseq


title: E8.5_plate5_F05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [252065]


title: plate4_D12_L004_AK6249-AK4241_RNAseq


title: E8.5_plate5_G04_RNAseq


title: E8.5_plate5_G02_RNAseq


title: E8.5_plate5_E11_RNAseq


title: E8.5_plate5_F04_RNAseq


title: plate4_D10_L004_AK9404-AK4241_RNAseq


title: E8.5_plate5_G08_RNAseq


title: E8.5_plate5_E10_RNAseq


title: E8.5_plate5_E09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [250709]


title: E8.5_plate5_F07_RNAseq


title: E8.5_plate5_F01_RNAseq


title: E8.5_plate5_F03_RNAseq


title: plate4_D11_L004_AK9170-AK4241_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [247671]


title: Whole blood DNA methylation_Discovery_MILD [246289]


title: E8.5_plate5_E12_RNAseq


title: plate4_D08_L004_AK7085-AK4241_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [249799]


title: E8.5_plate5_E04_RNAseq


title: plate4_D09_L004_AK6296-AK4241_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [244762]


title: E8.5_plate5_F06_RNAseq


title: E8.5_plate5_E08_RNAseq


title: E8.5_plate5_D12_RNAseq


title: E8.5_plate5_E06_RNAseq


title: E8.5_plate5_D10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [243218]


title: E8.5_plate5_E02_RNAseq


title: plate4_D06_L004_AK763-AK4241_RNAseq


title: plate4_D07_L004_AK8571-AK4241_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [24291]


title: E8.5_plate5_E05_RNAseq


title: E8.5_plate5_E07_RNAseq


title: E8.5_plate5_E01_RNAseq


title: plate4_D05_L004_5UDI219-AK4241_RNAseq


title: E8.5_plate5_D11_RNAseq


title: E8.5_plate5_D09_RNAseq


title: plate4_D04_L004_AK840-AK4241_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [242520]


title: plate4_D03_L004_5UDI265-AK4241_RNAseq


title: E8.5_plate5_D08_RNAseq


title: E8.5_plate5_D07_RNAseq


title: E8.5_plate5_D06_RNAseq


title: plate4_D02_L004_AK5426-AK4241_RNAseq


title: E8.5_plate5_D05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [241321]


title: plate4_D01_L004_AK2831-AK4241_RNAseq


title: E8.5_plate5_D03_RNAseq


title: E8.5_plate5_D02_RNAseq


title: E8.5_plate5_D04_RNAseq


title: plate4_C12_L004_AK6249-GA01_RNAseq


title: E8.5_plate5_D01_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [238637]


title: E8.5_plate5_C10_RNAseq


title: E8.5_plate5_C09_RNAseq


title: E8.5_plate5_C12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [238230]


title: E8.5_plate5_C11_RNAseq


title: plate4_C10_L004_AK9404-GA01_RNAseq


title: E8.5_plate5_E03_RNAseq


title: plate4_C11_L004_AK9170-GA01_RNAseq


title: E8.5_plate5_C06_RNAseq


title: E8.5_plate5_C08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [237245]


title: Whole blood DNA methylation_Discovery_SEVERE [241772]


title: E8.5_plate5_C07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [237743]


title: plate4_C09_L004_AK6296-GA01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [2400]


title: E8.5_plate5_C05_RNAseq


title: plate4_C08_L004_AK7085-GA01_RNAseq


title: E8.5_plate5_C02_RNAseq


title: E8.5_plate5_C04_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [235225]


title: E8.5_plate5_C03_RNAseq


title: E8.5_plate5_C01_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [233635]


title: Whole blood DNA methylation_Discovery_SEVERE [238166]


title: plate4_C06_L004_AK763-GA01_RNAseq


title: plate4_C05_L004_5UDI219-GA01_RNAseq


title: E8.5_plate5_B11_RNAseq


title: E8.5_plate5_B10_RNAseq


title: E8.5_plate5_B12_RNAseq


title: E8.5_plate5_B08_RNAseq


title: plate4_C04_L004_AK840-GA01_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [23240]


title: E8.5_plate5_B09_RNAseq


title: plate4_C03_L004_5UDI265-GA01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [231373]


title: plate4_C07_L004_AK8571-GA01_RNAseq


title: E8.5_plate5_B07_RNAseq


title: plate4_C01_L004_AK2831-GA01_RNAseq


title: E8.5_plate5_B05_RNAseq


title: plate4_C02_L004_AK5426-GA01_RNAseq


title: E8.5_plate5_B04_RNAseq


title: E8.5_plate5_B03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [22974]


title: E8.5_plate5_A12_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [230093]


title: E8.5_plate5_B06_RNAseq


title: plate4_B12_L004_AK6249-AK4240_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [228198]


title: E8.5_plate5_A10_RNAseq


title: E8.5_plate5_B02_RNAseq


title: E8.5_plate5_B01_RNAseq


title: plate4_B11_L004_AK9170-AK4240_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [225498]


title: E8.5_plate5_A08_RNAseq


title: plate4_B09_L004_AK6296-AK4240_RNAseq


title: plate4_B10_L004_AK9404-AK4240_RNAseq


title: E8.5_plate5_A11_RNAseq


title: E8.5_plate5_A09_RNAseq


title: plate4_B08_L004_AK7085-AK4240_RNAseq


title: E8.5_plate5_A05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [225973]


title: Whole blood DNA methylation_Discovery_MILD [222661]


title: E8.5_plate5_A06_RNAseq


title: E8.5_plate5_A04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [220340]


title: plate4_B07_L004_AK8571-AK4240_RNAseq


title: plate4_B06_L004_AK763-AK4240_RNAseq


title: E8.5_plate5_A03_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [220317]


title: E8.5_plate5_A01_RNAseq


title: E8.5_plate4_H11_RNAseq


title: E8.5_plate5_A02_RNAseq


title: E8.5_plate4_H12_RNAseq


title: plate4_B04_L004_AK840-AK4240_RNAseq


title: plate4_B05_L004_5UDI219-AK4240_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [224510]


title: Whole blood DNA methylation_Discovery_MILD [216883]


title: Whole blood DNA methylation_Discovery_SEVERE [215720]


title: Whole blood DNA methylation_Discovery_MILD [213599]


title: E8.5_plate4_H10_RNAseq


title: E8.5_plate4_H09_RNAseq


title: E8.5_plate4_H07_RNAseq


title: E8.5_plate4_H08_RNAseq


title: E8.5_plate4_H05_RNAseq


title: plate4_B03_L004_5UDI265-AK4240_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [211709]


title: E8.5_plate4_H04_RNAseq


title: plate4_B02_L004_AK5426-AK4240_RNAseq


title: E8.5_plate4_H06_RNAseq


title: plate4_B01_L004_AK2831-AK4240_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [213020]


title: plate4_A12_L004_AK6249-AK4239_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [209834]


title: E8.5_plate4_H03_RNAseq


title: E8.5_plate4_H01_RNAseq


title: plate4_A11_L004_AK9170-AK4239_RNAseq


title: E8.5_plate5_A07_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [208485]


title: Whole blood DNA methylation_Discovery_MILD [208244]


title: E8.5_plate4_G10_RNAseq


title: E8.5_plate4_G11_RNAseq


title: E8.5_plate4_G09_RNAseq


title: plate4_A10_L004_AK9404-AK4239_RNAseq


title: plate4_A09_L004_AK6296-AK4239_RNAseq


title: E8.5_plate4_G08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [207030]


title: E8.5_plate4_G05_RNAseq


title: E8.5_plate4_G06_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [207167]


title: plate4_A08_L004_AK7085-AK4239_RNAseq


title: plate4_A07_L004_AK8571-AK4239_RNAseq


title: E8.5_plate4_G01_RNAseq


title: E8.5_plate4_G07_RNAseq


title: E8.5_plate5_F12_RNAseq


title: E8.5_plate4_G04_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [205822]


title: E8.5_plate4_G03_RNAseq


title: E8.5_plate4_H02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [207489]


title: E8.5_plate4_G02_RNAseq


title: plate4_A05_L004_5UDI219-AK4239_RNAseq


title: E8.5_plate4_F11_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [203835]


title: E8.5_plate4_F12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [201893]


title: E8.5_plate4_F08_RNAseq


title: E8.5_plate4_F10_RNAseq


title: E8.5_plate4_F09_RNAseq


title: plate4_A04_L004_AK840-AK4239_RNAseq


title: plate4_A03_L004_5UDI265-AK4239_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [200896]


title: E8.5_plate4_F07_RNAseq


title: plate4_A06_L004_AK763-AK4239_RNAseq


title: E8.5_plate4_G12_RNAseq


title: plate4_A02_L004_AK5426-AK4239_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [198479]


title: E8.5_plate4_F05_RNAseq


title: E8.5_plate4_F06_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [198870]


title: plate3_H12_L003_AK8593-GC03_RNAseq


title: E8.5_plate4_F03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [198056]


title: E8.5_plate4_F01_RNAseq


title: plate3_H11_L003_AK2875-GC03_RNAseq


title: E8.5_plate4_F04_RNAseq


title: E8.5_plate4_E09_RNAseq


title: E8.5_plate4_E07_RNAseq


title: plate3_H09_L003_AK675-GC03_RNAseq


title: E8.5_plate4_E11_RNAseq


title: plate4_A01_L004_AK2831-AK4239_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [194960]


title: E8.5_plate4_E12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [193322]


title: Whole blood DNA methylation_Validation_NEGATIVE [194357]


title: E8.5_plate4_E08_RNAseq


title: E8.5_plate4_E06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [196476]


title: E8.5_plate4_E05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [193622]


title: E8.5_plate4_E04_RNAseq


title: E8.5_plate4_E02_RNAseq


title: E8.5_plate4_E10_RNAseq


title: plate3_H07_L003_5UDI210-GC03_RNAseq


title: E8.5_plate4_E01_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [248640]


title: E8.5_plate4_D12_RNAseq


title: plate3_H06_L003_AK8586-GC03_RNAseq


title: E8.5_plate4_F02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [190605]


title: plate3_H05_L003_AK7508-GC03_RNAseq


title: E8.5_plate4_D11_RNAseq


title: plate3_H04_L003_AK7759-GC03_RNAseq


title: E8.5_plate4_D09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [19237]


title: E8.5_plate4_E03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [187390]


title: E8.5_plate4_D07_RNAseq


title: plate3_H08_L003_AK8587-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [189027]


title: plate3_H03_L003_5UDI272-GC03_RNAseq


title: E8.5_plate4_D05_RNAseq


title: E8.5_plate4_D08_RNAseq


title: plate3_H10_L003_AK6743-GC03_RNAseq


title: E8.5_plate4_D04_RNAseq


title: E8.5_plate4_D06_RNAseq


title: E8.5_plate4_D03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [185762]


title: plate3_H02_L003_5UDI267-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [181481]


title: E8.5_plate4_D01_RNAseq


title: E8.5_plate4_D10_RNAseq


title: plate3_G11_L003_AK2875-GG01_RNAseq


title: plate3_G12_L003_AK8593-GG01_RNAseq


title: E8.5_plate4_C12_RNAseq


title: E8.5_plate4_C11_RNAseq


title: plate3_H01_L003_AK7350-GC03_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [180502]


title: E8.5_plate4_C09_RNAseq


title: plate3_G10_L003_AK6743-GG01_RNAseq


title: E8.5_plate4_D02_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [179651]


title: E8.5_plate4_C08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [176324]


title: E8.5_plate4_C10_RNAseq


title: plate3_G09_L003_AK675-GG01_RNAseq


title: plate3_G07_L003_5UDI210-GG01_RNAseq


title: plate3_G08_L003_AK8587-GG01_RNAseq


title: E8.5_plate4_C07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [186976]


title: E8.5_plate4_C06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [175096]


title: E8.5_plate4_C04_RNAseq


title: E8.5_plate4_C05_RNAseq


title: E8.5_plate4_C03_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [174247]


title: Whole blood DNA methylation_Discovery_MILD [173816]


title: plate3_G06_L003_AK8586-GG01_RNAseq


title: E8.5_plate4_B12_RNAseq


title: E8.5_plate4_C01_RNAseq


title: E8.5_plate4_C02_RNAseq


title: E8.5_plate4_B11_RNAseq


title: E8.5_plate4_B08_RNAseq


title: E8.5_plate4_B09_RNAseq


title: plate3_G04_L003_AK7759-GG01_RNAseq


title: plate3_G03_L003_5UDI272-GG01_RNAseq


title: E8.5_plate4_B10_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [174011]


title: E8.5_plate4_B07_RNAseq


title: plate3_G05_L003_AK7508-GG01_RNAseq


title: E8.5_plate4_B06_RNAseq


title: E8.5_plate4_B05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [173327]


title: Whole blood DNA methylation_Discovery_NEGATIVE [171529]


title: E8.5_plate4_B01_RNAseq


title: plate3_G01_L003_AK7350-GG01_RNAseq


title: E8.5_plate4_B02_RNAseq


title: E8.5_plate4_A12_RNAseq


title: E8.5_plate4_B04_RNAseq


title: plate3_F11_L003_AK2875-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [16945]


title: E8.5_plate4_A11_RNAseq


title: E8.5_plate4_B03_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [171287]


title: E8.5_plate4_A10_RNAseq


title: plate3_F10_L003_AK6743-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [168794]


title: E8.5_plate4_A09_RNAseq


title: plate3_G02_L003_5UDI267-GG01_RNAseq


title: E8.5_plate4_A08_RNAseq


title: E8.5_plate4_A07_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [1680791]


title: E8.5_plate4_A06_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [169514]


title: E8.5_plate4_A05_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [1680767]


title: Whole blood DNA methylation_Discovery_NEGATIVE [1680763]


title: E8.5_plate4_A03_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [1680543]


title: E8.5_plate3_H12_RNAseq


title: E8.5_plate3_H11_RNAseq


title: plate3_F05_L003_AK7508-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [167363]


title: plate3_F07_L003_5UDI210-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [1680876]


title: E8.5_plate3_H09_RNAseq


title: plate3_F12_L003_AK8593-AK4247_RNAseq


title: plate3_F06_L003_AK8586-AK4247_RNAseq


title: plate3_F09_L003_AK675-AK4247_RNAseq


title: plate3_F03_L003_5UDI272-AK4247_RNAseq


title: plate3_F04_L003_AK7759-AK4247_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [173106]


title: Whole blood DNA methylation_Discovery_SEVERE [167089]


title: E8.5_plate3_H07_RNAseq


title: plate3_F08_L003_AK8587-AK4247_RNAseq


title: E8.5_plate4_A02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [1670333]


title: E8.5_plate3_H06_RNAseq


title: plate3_F02_L003_5UDI267-AK4247_RNAseq


title: E8.5_plate3_H05_RNAseq


title: E8.5_plate4_A01_RNAseq


title: E8.5_plate3_H10_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [1672043]


title: E8.5_plate4_A04_RNAseq


title: E8.5_plate3_H04_RNAseq


title: plate3_F01_L003_AK7350-AK4247_RNAseq


title: E8.5_plate3_H08_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [165971]


title: E8.5_plate3_H01_RNAseq


title: E8.5_plate3_H02_RNAseq


title: plate3_E12_L003_AK8593-GG06_RNAseq


title: E8.5_plate3_G10_RNAseq


title: E8.5_plate3_G11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [1645254]


title: plate3_E11_L003_AK2875-GG06_RNAseq


title: plate3_E10_L003_AK6743-GG06_RNAseq


title: E8.5_plate3_G12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [16412]


title: E8.5_plate3_G09_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [1583280]


title: Whole blood DNA methylation_Discovery_MILD [159562]


title: E8.5_plate3_G08_RNAseq


title: plate3_E09_L003_AK675-GG06_RNAseq


title: E8.5_plate3_H03_RNAseq


title: E8.5_plate3_G05_RNAseq


title: plate3_E07_L003_5UDI210-GG06_RNAseq


title: E8.5_plate3_G04_RNAseq


title: plate3_E08_L003_AK8587-GG06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [157736]


title: E8.5_plate3_G06_RNAseq


title: plate3_E06_L003_AK8586-GG06_RNAseq


title: Day7_DTR_Utricle_scATACseq

city: Bethesda

first: Erin

last: Jimenez

state: MD

address: 50 South Drive

department: NHGRI

country: USA

institute: NIH

data_processing:
Binary Base Call (BCL) files generated from an Illumina NextSeq 550 sequencer and converted to FASTQ files with Cell Ranger Version 3.0.2 (10x Genomics).  Cell Ranger Version 3.0.2 (10x Genomics) was used to demultiplex, for barcode processing, for single cell gene counts, for single-cell accessibility counts, and aggregating files. For bulk ATAC-seq, libraries were sequenced on an Illumina HiSeq 2500 platform and run as indexed 50 base single end reads. Bulk ATAC-seq reads were aligned to reference zebrafish genome (danRer11) using bowtie2. Peaks were called by MACS2 from individual replicate.
Genome_build: danRer11
Supplementary_files_format_and_content: scRNA-seq and scATAC-seq outputs were generated using the 10x Cell Ranger pipeline. scRNA-seq H5 (filtered feature bc matrix) files contain the UMI counts for each cell. scATAC-seq processed data files include three file formats per sample: CSV, TBI, and H5. CSV (singlecell.csv) files contain per barcode QC information associated with the fragments per barcode, ATAC signal per barcode, and cell calling information. TBI (Fragments.tsv.gz.tbi) files are tabix index of the fragment intervals. H5 (filtered peak bc matrix.h5) files contain only detected cellular barcodes. For bulk ATAC-seq, narrowPeak files contain MACS2 called peaks in BED format.

organism: Danio rerio

source_name: Regenerating adult zebrafish utricle

extract_protocol:
For single-cell experiments, non-regenerating (untreated) and regenerating inner ears (saccule and utricle) were dissected at consecutive time-points and dissociated into single-cells using trypsin and collagenase. For bulk ATAC-seq experiments, untreated inner ears (saccule and utricle) were harvested and samples prepared in triplicate. Nuclei were extracted and chromatin digested by tn5 transposase. DNA fragments were extracted and then amplified by PCR. Libraries were amplified by PCR with indexed primers.
For scRNA-seq, cDNA libraries were generatated with Chromium Controller and Chromium Single Cell 3' GEM, Library and Gel Bead Kit V3 (10x Genomics). For scATAC-seq, libraries were generated with the Chromium Controller and Chromium Single Cell ATAC Library & Gel Bead Kit (1000111, 10X Genomics). For bulk ATAC-seq, libraries were generated using Nextera DNA Library Preparation Kit (Catalog # FC-121-1030). Transposed DNA were amplified by PCR with indexed primers and libraries were purified.

tag: embryo age

value: 6-10 month old adult zebrafish

tag: treatment

value: 0.05 ng/ul Diphtheria Toxin


title: E8.5_plate3_G03_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [155606]


title: Day7_DTR_Saccule_scATACseq

source_name: Regenerating adult zebrafish saccule


title: Day5_DTR_Utricle_scATACseq


title: E8.5_plate3_G01_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [158151]


title: E8.5_plate3_G02_RNAseq


title: E8.5_plate3_F12_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [150811]


title: Day5_DTR_Saccule_scATACseq


title: Whole blood DNA methylation_Validation_NEGATIVE [150347]


title: plate3_E03_L003_5UDI272-GG06_RNAseq


title: Day4_DTR_Utricle_scATACseq


title: E8.5_plate3_F11_RNAseq


title: Day4_DTR_Saccule_scATACseq


title: plate3_E02_L003_5UDI267-GG06_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [1540949]


title: plate3_E01_L003_AK7350-GG06_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [149317]


title: E8.5_plate3_F10_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [149215]


title: plate3_E05_L003_AK7508-GG06_RNAseq


title: Untreated_DTR_Utricle_scATACseq

source_name: Untreated DTR utricle


title: E8.5_plate3_F09_RNAseq


title: plate3_D12_L003_AK8593-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [148666]


title: Untreated_DTR_Saccule_scATACseq

source_name: Untreated DTR saccule


title: plate3_E04_L003_AK7759-GG06_RNAseq


title: E8.5_plate3_F08_RNAseq


title: Day4_WT_Saccule_scATACseq

source_name: Day 4 post-DT wild-type saccule


title: Whole blood DNA methylation_Discovery_SEVERE [146189]


title: plate3_D11_L003_AK2875-AK4246_RNAseq


title: E8.5_plate3_F07_RNAseq


title: Untreated_WT_Utricle_scATACseq

source_name: Untreated wild-type utricle


title: Whole blood DNA methylation_Discovery_SEVERE [146054]


title: E8.5_plate3_F06_RNAseq


title: Untreated_WT_Saccule_scATACseq

source_name: Untreated wild-type saccule


title: plate3_D10_L003_AK6743-AK4246_RNAseq


title: plate3_D09_L003_AK675-AK4246_RNAseq


title: E8.5_plate3_F05_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [144008]


title: plate3_D08_L003_AK8587-AK4246_RNAseq


title: Day7_DTR_Utricle_scRNAseq


title: Day7_DTR_Saccule_scRNAseq


title: E8.5_plate3_F04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [144592]


title: plate3_D06_L003_AK8586-AK4246_RNAseq


title: E8.5_plate3_F03_RNAseq


title: plate3_D07_L003_5UDI210-AK4246_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [141932]


title: Whole blood DNA methylation_Discovery_MILD [141059]


title: plate3_D05_L003_AK7508-AK4246_RNAseq


title: E8.5_plate3_F01_RNAseq


title: E8.5_plate3_F02_RNAseq


title: Day5_DTR_Saccule_scRNAseq


title: plate3_D03_L003_5UDI272-AK4246_RNAseq


title: Day5_DTR_Utricle_scRNAseq


title: Day4_DTR_Utricle_scRNAseq


title: Whole blood DNA methylation_Discovery_MILD [138103]


title: plate3_D04_L003_AK7759-AK4246_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [140045]


title: E8.5_plate3_E12_RNAseq


title: E8.5_plate3_E11_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [142869]


title: Whole blood DNA methylation_Validation_NEGATIVE [135261]


title: plate3_D02_L003_5UDI267-AK4246_RNAseq


title: Day4_DTR_Saccule_scRNAseq


title: Untreated_DTR_Utricle_scRNAseq


title: plate3_C12_L003_AK8593-AK4245_RNAseq


title: E8.5_plate3_E09_RNAseq


title: plate3_D01_L003_AK7350-AK4246_RNAseq


title: Untreated_DTR_Saccule_scRNAseq


title: Whole blood DNA methylation_Discovery_MILD [134459]


title: E8.5_plate3_E10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [134046]


title: Whole blood DNA methylation_Discovery_MILD [133308]


title: plate3_C11_L003_AK2875-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [132772]


title: E8.5_plate3_E08_RNAseq


title: Day4_WT_Utricle_scRNAseq

source_name: Day 4 post-DT wild-type utricle


title: plate3_C09_L003_AK675-AK4245_RNAseq


title: E8.5_plate3_E07_RNAseq


title: SCC25-RNA-3

type: RNA

city: Tianjin

first: Wei

last: Zhao

address: Qixiangtai Road

country: China

institute: Tianjin medical university

description: Biological replicate 3 of 3. Tumor SCC25 cells

hyb_protocol: The hybridization was perforemd using anti-m6A antibody Synaptic Systems, cat. No. 202003). The reference genome was hg38 gencode. Through library construction, high-throughput sequencing and bioinformatics analysis, mapping of whole transcriptome m6A location was generated by Jiayin Biotechnology Ltd.

scan_protocol: hrough library construction, high-throughput sequencing and bioinformatics analysis, mapping of whole transcriptome m6A location was generated by Jiayin Biotechnology Ltd. (Shanghai, China)

data_processing:
The ‘m6A methylation level’ for a transcript was calculated as the percentage of modified RNA (modified %) in all RNAs based on the IP (Cy5-labelled) and Sup (Cy3-labelled) normalized intensities
Differentially m6A-methylated RNAs between two comparison groups were identified by filtering with the fold change (>1.5 fold) and statistical significance (p-value<0.05) thresholds.

label_protocol: Raw intensities of Sup (Supernatant, Cy3-labelled) and IP (Immunoprecipitated, Cy5-labelled) were normalized with average of log2-scaled Spike-in RNA intensities.

growth_protocol: HOK cells were cultured in Oral Keratinocyte Medium (OKM, Cat. No. 2611, ScienCell) recommended by ScienCell in vitro.

extract_protocol: Total RNA extracted using Trizol following manufacturer's instructions

treatment_protocol: OSCC cells (SCC25 cells) were provided by ATCC and cultured in DMEM Medium supplemented with fetal bovine serum (FBS, 10%), 100 U/ml penicillin, 100 μg/ml streptomycin.

tag: cell line

value: SCC25 cells

value: tumor cells


title: plate3_C10_L003_AK6743-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [128677]


title: Whole blood DNA methylation_Discovery_MILD [130623]


title: Whole blood DNA methylation_Discovery_MILD [132134]


title: Untreated_WT_Saccule_scRNAseq


title: E8.5_plate3_E03_RNAseq


title: E8.5_plate3_E04_RNAseq


title: E8.5_plate3_E05_RNAseq


title: plate3_C07_L003_5UDI210-AK4245_RNAseq


title: plate3_C08_L003_AK8587-AK4245_RNAseq


title: plate3_C05_L003_AK7508-AK4245_RNAseq


title: plate3_C06_L003_AK8586-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [127256]


title: E8.5_plate3_E02_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [127107]


title: NC-3

description: Biological replicate 3 of 3. Normal HOK cells

value: HOK cells

value: normal cells


title: E8.5_plate3_E06_RNAseq

value: E8.5 embryo


title: SCC25-RNA-2

description: Biological replicate 2 of 3. Tumor SCC25 cells


title: Day4_WT_Saccule_scRNAseq


title: SCC25-RNA-1

description: Biological replicate 1 of 3. Tumor SCC25 cells


title: E8.5_plate3_E01_RNAseq


title: plate3_C04_L003_AK7759-AK4245_RNAseq

value: E7.5 embryo


title: NC-2

description: Biological replicate 2 of 3. Normal HOK cells


title: E8.5_plate3_D12_RNAseq


title: plate3_C03_L003_5UDI272-AK4245_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [126536]

value: SARS-CoV-2 positive individual

value: F


title: NC-1

description: Biological replicate 1 of 3. Normal HOK cells


title: Whole blood DNA methylation_Discovery_MILD [126254]

value: Discovery

value: MILD


title: E8.5_plate3_D11_RNAseq


title: plate3_C01_L003_AK7350-AK4245_RNAseq


title: Untreated_WT_Utricle_scRNAseq


title: Vitroretinal lymphoma 28

city: Barcelona

first: Joan

middle: Enric

last: Ramiz-Zaldivar

address: Rosselló, 153

department: Molecular Pathology Laboratory

institute: IDIBAPS

description: Hybridized to Affymetrix OncoScan FFPE Assay

hyb_protocol: Affymetrix OncoScan™ FFPE Assay kit /GPL18602

scan_protocol: Affymetrix® GeneChip® Scanner 3000G to detect target bound to Oncoscan array after staining with Biotin.

data_processing:
Nexus biodiscovery software
Gains and losses were evaluated with visual inspection by 2 different observers using Nexus Biodiscovery software (Biodiscovery, Hawthorne CA, USA). The CNAs with a minimum size of 100kb were considered real. Loss of heterozigosity regions where considered when size was >5Mb.

label: Biotin

source_name: Retinal biopsy

extract_protocol: Genomic DNA was extracted from FFPE samples after dewaxing and proteinase K digestion applying standard phenol/chloroform purification procedures or using the Maxwell® RSC DNA FFPE Kit and the Maxwell® RSC Instrument (Promega, Madison, WI, USA) according to the manufacturer’s instructions.

tag: type of sample

value: Vitroretinal lymphoma

value: Male

value: FFPE


title: E8.5_plate3_G07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [12498]

value: M

value: Whole Blood


title: Vitroretinal lymphoma 26

label_protocol: Affymetrix OncoScan™ FFPE Assay kit /GPL18602

value: Female


title: Vitroretinal lymphoma 25


title: E8.5_plate3_D10_RNAseq


title: plate3_B11_L003_AK2875-AK4244_RNAseq


title: E8.5_plate3_D08_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [12515]

value: SEVERE


title: plate3_C02_L003_5UDI267-AK4245_RNAseq


title: E8.5_plate3_D09_RNAseq


title: E8.5_plate3_D07_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [123774]

value: SARS-CoV-2 negative individual

value: Validation

value: NEGATIVE


title: Vitroretinal lymphoma 22


title: plate3_B10_L003_AK6743-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [126024]


title: Whole blood DNA methylation_Discovery_SEVERE [119765]


title: plate3_B09_L003_AK675-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [119833]


title: Vitroretinal lymphoma 16.1


title: plate3_B12_L003_AK8593-AK4244_RNAseq


title: E8.5_plate3_D06_RNAseq


title: E8.5_plate3_D05_RNAseq


title: Whole blood DNA methylation_Discovery_NEGATIVE [119624]


title: plate3_B08_L003_AK8587-AK4244_RNAseq


title: Vitroretinal lymphoma 3


title: plate3_B07_L003_5UDI210-AK4244_RNAseq


title: E8.5_plate3_D04_RNAseq


title: Whole blood DNA methylation_Validation_NEGATIVE [117711]


title: plate3_B05_L003_AK7508-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [117477]


title: plate3_B04_L003_AK7759-AK4244_RNAseq


title: Vitroretinal lymphoma 16.2


title: Whole blood DNA methylation_Discovery_MILD [114517]


title: E8.5_plate3_D01_RNAseq


title: plate3_B03_L003_5UDI272-AK4244_RNAseq


title: E8.5_plate3_D02_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [115607]


title: E8.5_plate3_C12_RNAseq


title: Non_Pregnant_NSG_LIRKO_Donor_4

city: Boston

first: Jonathan

middle: M

last: Dreyfuss

state: MA

address: 1 Joslin Pl

department: Bioinformatics & Biostatistics Core

institute: Joslin Diabetes Center

description:
10x Genomics
S15

library_source: transcriptomic single cell

data_processing:
Raw sequencing data were demultiplexed, aligned to the joint human (GRCh38) and mouse (mm10) genomes, and UMI-collapsed by using CellRanger (4.0.0). Cells with more than 25% of mouse gene counts were discarded. In the remaining cells, mouse gene counts were discarded.
Assembly: GRCh38
Supplementary files format and content: CSV of counts

source_name: Pancreatic islet and duct graft

extract_protocol:
Gel Beads in Emulsion (GEMs) were generated using the Chromium 3’ Single Cell Library Kit (v2, 10X Genomics, CA) according to the manufacturer’s instructions. Briefly, 10,000 nuclei were combined with Single Cell Master Mix and encapsulated into the barcoded Gel Beads through the Chromium™ Controller.
After GEM-RT incubation, cDNA samples were recovered, purified and amplified through a cDNA Amplification Reaction. Quality controls on amplified cDNA samples were carried out through using a High Sensitivity DNA Kit (Agilent, CA) on a 2100 BioAnalizer (Agilent, CA) platform. Libraries were then constructed following Fragmentation and Adaptor Ligation and Sample Index incorporation. Finally, purified libraries were run on 2100 BioAnalizer (Agilent, CA) using a High Sensitivity DNA Kit (Agilent, CA) to evaluate the quality of the ~400bp fragments.

value: Pancreatic islet and duct graft

tag: cell type

value: Pancreatic islet and duct

tag: cell barcode_suffix

tag: donor


title: Pregnant_NSG_LIRKO_Donor_4

description:
10x Genomics
S16


title: Whole blood DNA methylation_Validation_NEGATIVE [114463]


title: Pregnant_NSG_LIRKO_Donor_3

description:
10x Genomics
S12


title: Pregnant_NSG_Lox_Donor_4

description:
10x Genomics
S14


title: plate3_B06_L003_AK8586-AK4244_RNAseq

value: E7.5 embryo


title: plate3_B02_L003_5UDI267-AK4244_RNAseq


title: Non_Pregnant_NSG_Lox_Donor_4

description:
10x Genomics
S13


title: E8.5_plate3_C10_RNAseq

value: E8.5 embryo


title: E8.5_plate3_C11_RNAseq


title: E8.5_plate3_D03_RNAseq


title: E8.5_plate3_C09_RNAseq


title: Pregnant_NSG_Lox_Donor_3

description:
10x Genomics
S10


title: Whole blood DNA methylation_Discovery_MILD [114269]

value: SARS-CoV-2 positive individual

value: F


title: plate3_B01_L003_AK7350-AK4244_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [113790]

value: Discovery

value: MILD


title: Non_Pregnant_NSG_Lox_Donor_3

description:
10x Genomics
S9


title: Whole blood DNA methylation_Discovery_MILD [112648]


title: Pregnant_NSG_LIRKO_Donor_2

description:
10x Genomics
S8


title: E8.5_plate3_C08_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [112451]


title: E8.5_plate3_C07_RNAseq


title: plate3_A11_L003_AK2875-GC07_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [112139]


title: E8.5_plate3_C06_RNAseq


title: plate3_A10_L003_AK6743-GC07_RNAseq


title: plate3_A09_L003_AK675-GC07_RNAseq


title: Non_Pregnant_NSG_LIRKO_Donor_2

description:
10x Genomics
S7


title: Pregnant_NSG_Lox_Donor_2

description:
10x Genomics
S6


title: plate3_A08_L003_AK8587-GC07_RNAseq


title: E8.5_plate3_C05_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [110638]


title: Non_Pregnant_NSG_LIRKO_Donor_3

description:
10x Genomics
S11


title: E8.5_plate3_C04_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [110937]


title: E8.5_plate3_C03_RNAseq


title: Pregnant_NSG_LIRKO_Donor_1

description:
10x Genomics
S4


title: plate3_A12_L003_AK8593-GC07_RNAseq


title: plate3_A07_L003_5UDI210-GC07_RNAseq


title: Non_Pregnant_NSG_Lox_Donor_2

description:
10x Genomics
S5


title: Non_Pregnant_NSG_LIRKO_Donor_1

description:
10x Genomics
S3


title: Whole blood DNA methylation_Discovery_MILD [108787]


title: Whole blood DNA methylation_Discovery_SEVERE [108670]


title: E8.5_plate3_C02_RNAseq


title: Pregnant_NSG_Lox_Donor_1

description:
10x Genomics
S2


title: Whole blood DNA methylation_Discovery_MILD [107894]


title: E8.5_plate3_C01_RNAseq


title: Non_Pregnant_NSG_Lox_Donor_1

description:
10x Genomics
S1


title: E8.5_plate3_B12_RNAseq


title: E8.5_plate3_B11_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [107471]


title: plate3_A03_L003_5UDI272-GC07_RNAseq


title: plate3_A06_L003_AK8586-GC07_RNAseq


title: plate3_A02_L003_5UDI267-GC07_RNAseq


title: E8.5_plate3_B10_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [106636]


title: Whole blood DNA methylation_Discovery_MILD [10556]


title: Whole blood DNA methylation_Discovery_MILD [105437]


title: Whole blood DNA methylation_Discovery_SEVERE [105280]


title: E8.5_plate3_B07_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [10585]


title: plate2_H12_L002_AK3914-AK4243_RNAseq


title: plate3_A01_L003_AK7350-GC07_RNAseq


title: plate2_H09_L002_AK3910-AK4243_RNAseq


title: plate3_A04_L003_AK7759-GC07_RNAseq


title: plate3_A05_L003_AK7508-GC07_RNAseq


title: plate2_H11_L002_AK16886-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [104425]


title: plate2_H10_L002_AK7505-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [105191]


title: E8.5_plate3_B06_RNAseq


title: E8.5_plate3_B05_RNAseq


title: E8.5_plate3_B09_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [104111]


title: plate2_H08_L002_AK2870-AK4243_RNAseq


title: E8.5_plate3_B04_RNAseq


title: Dt47.day9.clone.E7

first: Stuart

middle: H

last: Orkin

address: 1 Blackfan Circle KFRB 07007H

department: Hematology/Oncology

institute: Dana-Farber Cancer Institute/Boston Children's hospital

data_processing:
Library strategy: Bisulfite-treated Amplicon-seq
Fastq files were aligned to twp custom-made human genomes covering the b-globin locus only: (1) a genome in which all the cytosines (C) are converted to uracil (U), read as thymine (T) by the Illumina sequencer; (2) a genome which is the wild-type human genome of the b-globin locus.
DNA sequences are expected to partially align to the custom-made genomes, depending on the extent of bisulfite conversion. Because perfect alignment will not be expected due to differing methylation levels across the CpGs, we scanned for partially aligned sequences and subject them to a second step of counting.
For this second step, a computer program was written to locally align each sequence to the entire amplicon again, but this time counted the number of converted cytosines at each of 8 CpG loci, which is seen as a mismatched base T compared to the wildtype genome in the local alignment.
Methylation frequencies were computed at each CpG locus as the number of aligned sequences containing the converted cytosine at the locus, normalized by the total number of aligned sequences covering the locus (the sum of converted cytosines and unconverted cytosines)
Sequences were first trimmed using Trimmomatic (v0.36) with parameters: 2:15:4:4:true LEADING:20 TRAILING:20  SLIDINGWINDOW:4:15 MINLEN:25. Alignment was performed using Bowtie2 (version 2.2.9) with parameters -p 2 –dovetail –phred33 using the custom genome.
Genome_build: custom genome hg19
Supplementary_files_format_and_content: The processed file list the DNA methylation status of each of 8 CpG loci in the b-globin locus. For each sequence, it shows three columns: column 1 is the CpG genomic position (along the b-globin locus), column 2 is the wildtype sequence (it is always C), column 3 is the methylation status (T if C is unmethylated; C if C is methylated).

source_name: HUDEP2 cells

growth_protocol: HUDEP-2 lines (human umbilical cord blood-derived erythroid progenitor, male) were provided by Dr. Yukio Nakamura. HUDEP-2 cells were cultured as described previously (Vinjamur and Bauer 2018). Briefly, cells were maintained at a density of <0.5x106 in expansion medium: StemSpan™ SFEM (STEMCELL Technologies, 09650) with SCF (50 ng/ml), EPO (3 IU/ml), Dexamethasone (10−6 M), Doxycycline (1 μg/ml), and passaged every other day. Erythroid differentiation was carried out by replacing the medium to EDM2 (Erythroid Differentiation Media: IMDM (Corning, 15–016-CV) supplemented with 330 μg/mL HoloHuman Transferrin, 10 μg/mL Recombinant Human Insulin, 2 IU/mL Heparin, 5% Inactivated Plasma, 3 IU/mL Erythropoietin, 2 mM L-Glutamine, 100 ng/mL SCF, 1 μg/mL doxycycline).

extract_protocol:
On the day of the experiment, DNA was extracted from frozen pellets with an Allprep DNA/RNA Mini Kit (Qiagen). Bisulfite conversion was performed on 1 μg DNA with an Epitect kit (Qiagen), and a 457bp region of the HBG1/2 promoter region was amplified by nested PCR as described previously (Mehta et al. 2015).
PCR amplicons were sent for Illumina Amplicon next-generation sequencing (Genewiz), yielding 2x250 bp reads.

treatment_protocol: Cells were resuspended in medium containing 0.15uM dTAG-47. Every other day, cells were centrifuged at 500g for 5min at 4C and resuspended in fresh media containing the drug. HUDEP-2 cells were cultured in differentiating media containing DMSO or 0.15uM

tag: day

tag: state

value: Clone E7


title: Dt47.day9.WT

value: WT


title: Whole blood DNA methylation_Discovery_MILD [103811]


title: E8.5_plate3_B08_RNAseq

tag: strain


title: E8.5_plate3_B03_RNAseq

tag: tissue


title: Dt47.day7.WT


title: E8.5_plate3_B01_RNAseq


title: plate2_H05_L002_AK9173-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [101573]

tag: subject status


title: Dt47.day7.clone.E7


title: Whole blood DNA methylation_Discovery_MILD [101417]

tag: age


title: plate2_H04_L002_AK7737-AK4243_RNAseq


title: Whole blood DNA methylation_Discovery_MILD [100165]

tag: gender


title: E8.5_plate3_A12_RNAseq


title: Whole blood DNA methylation_Discovery_SEVERE [100120]

tag: cohort


title: plate2_H02_L002_7UDI1240-AK4243_RNAseq


title: plate2_H03_L002_AK10266-AK4243_RNAseq


title: Dt47.day7.clone.B9

value: Clone B9


title: Dt47.day4.clone.B9


title: Dt47.day4.clone.E7


title: E8.5_plate3_A11_RNAseq


title: E8.5_plate3_A10_RNAseq


title: hsc pIpC 20wk 3

city: Heidelberg

first: Sina

last: Stäble

address: Im Neuenheimer Feld 280

department: Translational Cancer Epigenomics

country: Germany

institute: German Cancer Research Center (DKFZ)

data_processing:
For each cell, reads were aligned to the murine genome (ERCC sequences concatenated to GRCm38.p4 version 84, softmasked) with STAR version 2.5.
Raw counts were quantified from position-sorted alignment files with HTSeq-count using mode 'union' and default quality thresholds of 10. Cells were excluded as low quality if more than 40 % of counts were in ERCCs, or if the counts in murine exons were more than 10 % mitochondrial or less than 0.5 Mio in total. In addition, cells for which less than 2,000 genes were expressed were excluded; resulting in a total of 564 cells passing quality control.
Size-factor normalization (Love et al., 2014) was used to identify variable genes using a log-linear fit capturing the relationship between mean and squared coefficient of variation (CV) of the log-transformed, TPM data (Brennecke et al., 2013). Genes with a squared CV greater than the estimated squared baseline CV were then considered as variable beyond technical noise.
A projection analysis was performed to integrate our own data with a larger hematopoietic dataset covering a wider range of blood stem and progenitor cells (Nestorowa et al., 2016). To this end, the intersection of variable genes identified in (Nestorowa et al., 2016) and our data was established.
A diffusion map representation of the 1656 cells from (Nestorowa et al., 2016) was then generated, based on the 1616 genes that were variable above technical noise both in our data and the data from (Nestorowa et al., 2016). Our cells were then projected into the diffusion map span based on the diverse set of stem and progenitor cells from (Nestorowa et al., 2016) using the destiny R package (Angerer et al., 2016).
Assembly: GRCm38.p4 version 84
Supplementary files format and content: 3 countmatrices (160531_SN7001427_0222_AC9C6UANXXcountmatrix.csv contains information about samples 1-6, 170713_SN7001427_0332_ACB2FUANXXcountmatrix.csv about samples 7-8 and matrix 170713_D00392_0176_ACB365ANXXcountmatrix.csv about sample 9). In the countmatrices stored in this directory, each cell (matrix colum) has a name such as AS-172639-LR-27156. The '172639' is a unique cell identifier, whereas the '27156' is common to all cells derived from the same plate as this example cell.

source_name: LT-HSC

extract_protocol:
To isolate purified LT-HSCs from the murine bone marrow, density gradient centrifugation was performed to enrich low-density mononuclear cell (LDMNCs), followed by lineage depletion of mature hematopoietic cell lineages using rat anti-mouse biotin-conjugated lineage antibodies and Biotin Binder Dynabeads (Life Technologies). LT-HSCs were then isolated from lineage-negative bone marrow cells by fluorescence activated cell sorting. Single LT-HSC cells were subsequently captured on a small sized IFC using the Fluidigm C1 system. Briefly, cells were washed, re-suspended in PBS supplemented with C1 suspension buffer in a 4:1 ratio and 400 cells/µl were loaded onto the chip. After cell capture, each position on the chip was imaged and only single cells were included in the downstream library preparation and analysis.
Sequencing libraries were produced with the Illumina Nextera XT kit according to the adopted Fluidigm protocol. Bulk samples, i.e. 100 cells pooled together and then processed as with the same protocol. Bulk samples in 5week data are:  "AS-117588-LR-16803", "AS-117747-LR-16804", "AS-117900-LR-16805", "AS-118051-LR-16806", "AS-118210-LR-16807", "AS-118357-LR-16808". In the 20 week data, the bulk samples are: "AS-172797-LR-27156", "AS-172545-LR-27143" and "AS-172630-LR-27144".

treatment_protocol: To mimic a repetitive sterile inflammatory response in vivo, wild-type C57BL/6J mice were subjected to a three round pI:pC dose escalation regimen. Mice were serially injected intraperitoneally (i.p.) with 5 mg/kg high molecular weight polyinosinic:polycytidylic acid (pI:pC, InvivoGen), which had been reconstituted in sterile physiologic saline precisely as described in the manufacturer’s instructions. Control mice were injected with the same volume of PBS (Sigma Aldrich). One round of pI:pC treatment corresponds to 8 individual injections spread over the course of 4 weeks, followed by a 4 week recovery period prior to the next round of treatment.

value: 40 weeks

tag: time point

value: 20 weeks


title: plate2_H07_L002_AK9176-AK4243_RNAseq

source_name: Early embryo


title: plate2_H01_L002_AK5577-AK4243_RNAseq


title: Dt47.day9.clone.B9


title: DMSO.day9.clone.E7

value: DMSO


title: hsc pIpC 20wk 1

description: 170713_SN7001427_0332_ACB2FUANXXcountmatrix.csv


title: plate2_H06_L002_5UDI232-AK4243_RNAseq


title: E8.5_plate3_B02_RNAseq


title: plate2_G12_L002_AK3914-AK903_RNAseq


title: E8.5_plate3_A08_RNAseq


title: plate2_G11_L002_AK16886-AK903_RNAseq


title: E8.5_plate3_A07_RNAseq


title: hsc pIpC 5wk 3

description: 160531_SN7001427_0222_AC9C6UANXXcountmatrix.csv

value: 5 weeks


title: DMSO.day7.WT


title: DMSO.day9.WT


title: hsc pIpC 5wk 2


title: plate2_G09_L002_AK3910-AK903_RNAseq


title: hsc pIpC 20wk 2


title: DMSO.day9.clone.B9


title: plate2_G07_L002_AK9176-AK903_RNAseq


title: E8.5_plate3_A06_RNAseq


title: plate2_G08_L002_AK2870-AK903_RNAseq


title: E8.5_plate3_A05_RNAseq


title: DMSO.day7.clone.E7


title: E8.5_plate3_A09_RNAseq


title: DMSO.day4.clone.E7


title: E8.5_plate3_A04_RNAseq


title: E8.5_plate3_A03_RNAseq


title: hsc pbs 3

value: PBS


title: plate2_G06_L002_5UDI232-AK903_RNAseq


title: hsc pbs 2


title: plate2_G10_L002_AK7505-AK903_RNAseq


title: hsc pbs 1


title: E8.5_plate3_A02_RNAseq


title: plate2_G05_L002_AK9173-AK903_RNAseq


title: hsc pIpC 5wk 1


title: E8.5_plate3_A01_RNAseq


title: hsc_aged_5

description: bisulfite converted genomic DNA

data_processing:
Sequence alignment was performed using an updated version of the workflow published in (Wang et al., Nat. Prot., 2013). The workflow was implemented as a Roddy Workflow  (https://github.com/DKFZ-ODCF/AlignmentAndQCWorkflows). Alignment was performed against the mm10 reference genome extended with the PhiX and lambda phage sequences. Briefly, before alignment, trimmomatic was used for adapter trimming and reads were in silico converted (C>T for the first read in the pair, G>A for the second). Alignments of the individual libraries were performed against the concatenated C>T and G>A in silico converted reference genomes using bwa mem with default parameters. After alignment, reads were converted back to their original state.
PCR duplicate removal was performed per library using Picard MarkDuplicates before merging reads from all libraries.
At each cytosine position, reads that maintain the cytosine status were considered methylated, and the reads that have cytosine converted to thymine were considered unmethylated.
Only reads with a mapping quality >= 25 and bases with Phred-scaled quality score ≥25 were considered for methylation calling.
At least the first 9 bp of the second read and last 9 bp before the adapter in the first read were excluded from methylation calling. The in silico conversion and methylation calling steps were performed using bistro (https://github.com/stephenkraemer/bistro).
Assembly: mm10
Supplementary files format and content: QC-filtered methylation calls for all autosomal CpGs in BED6+3 format, with the following columns: chrom, start, end, motif, score, strand, beta_value, n_meth, n_total. The two cytosines in a CpG motif were merged, and the CpG position is given on the plus strand. The score column holds no information (always '.').

extract_protocol:
To isolate purified LT-HSCs from the murine bone marrow, density gradient centrifugation was performed to enrich low-density mononuclear cell (LDMNCs), followed by lineage depletion of mature hematopoietic cell lineages using rat anti-mouse biotin-conjugated lineage antibodies and Biotin Binder Dynabeads (Life Technologies). LT-HSCs were then isolated from lineage-negative bone marrow cells by fluorescence activated cell sorting. DNA was isolated from snap-frozen cell pellets (15.000 - 20.000 sorted cells) using the QIAamp DNA Micro Kit (Qiagen) according to the manufacturer’s instructions.
Tagmentation-based whole-genome bisulfite sequencing (TWGBS) libraries were prepared as described previously (Wang et al., Nat. Prot., 2013). We used 10-30 ng genomic DNA as input.

value: 130 weeks

value: untreated


title: Day0.WT


title: Day0.clone.E7


title: plate2_G03_L002_AK10266-AK903_RNAseq


title: E8.5_plate2_H12_RNAseq


title: DMSO.day7.clone.B9


title: Day0.KO


title: hsc_aged_4

description: bisulfite converted genomic DNA


title: hsc_aged_3

description: bisulfite converted genomic DNA

value: 119 weeks


title: plate2_G02_L002_7UDI1240-AK903_RNAseq

value: E7.5 embryo


title: hsc_aged_2

description: bisulfite converted genomic DNA

value: 111 weeks


title: E8.5_plate2_H10_RNAseq

value: E8.5 embryo


title: DMSO.day4.clone.B9


title: Day0.clone.B9


title: plate2_G01_L002_AK5577-AK903_RNAseq


title: E8.5_plate2_H11_RNAseq


title: hsc_pIpC_3

description: bisulfite converted genomic DNA

value: 32-36 weeks

value: pIpC


title: hsc_aged_1

description: bisulfite converted genomic DNA