title: hsSKM_ChIP_H3_rep1

first: Mingwei

last: Feng

state: Tianjin

address: Weijin road No.92

department: SPST

data_processing:
raw reads were trimmed using TrimGalore (Galaxy Version 0.6.7) on Galaxy (https://usegalaxy.org) to remove extra adapters
raw reads were mapped to the reference genome (GRCh38 for human) using Bowtie2 (Galaxy Version 2.4.2)  to generate BAM file.
Bigwig files were generated from the BAM files using bamCoverage (Galaxy Version 3.5.1.0.0).
Heatmap was created using computeMatrix (Galaxy Version 3.5.1.0.0) and plotProfile (Galaxy Version 3.5.1.0.0).
Motif analysis was performed using MEME-ChIP - motif discovery (Galaxy Version 4.11.2).
Assembly: hg38
Supplementary files format and content: bigwig files

source_name: Skeletal muscle cell

growth_protocol: Human skeleton muscle cells were cultured in 10% FBS DMEM medium to 50-70% confluency on three 10cm tissue culture dishes for each sample.

extract_protocol:
The samples were extracted using a SimpleChIP Enzymatic Chromatin IP kit (#9003; Cell Signaling Technologies). Cells were cross-linked with 1 % formaldehyde in DMEM complete medium at room temperature for 10 min, neutralized with 10 % 1 M glycine at room temperature for 5 min and washed with PBS. Fixed cells were lysed with 1 ml Buffer A+DTT+PIC for 10 min on ice to isolate nuclear. Isolated nuclear were washed with buffer B+DTT for 3 times then diluted in 100 ul buffer B+DTT and Chromatin were digested with 0.5 ul Micrococcal Nuclease #10011 at 37°C for 20 mins, then 10 μl 0.5 M EDTA #7011 was added to terminate digestion. Digested nuclear were diluted in 500ul ChIP buffer, sonicated with ultrasonic processor (Ningbo sinentz biotechnology CO.,LTD) at sonications of 5 s with 30-s intervals, 12 times at 20 % AMPL, and cleared by centrifugation at 9400 g for 10 min at 4°C. The supernatants were incubated with 3 ug rabbit anti-UBE2A antibody (PA5-29940, invtrogen) or rabbit anti-histone H3 (a technical positive control, #4620, Cell Signaling Technologies) overnight with rotation, then incubated with 30 ul Protein G Magnetic Beads (#9006) for 2 hours with rotation.   The immune complexes were washed with 1 ml low salt buffer (1XChIP buffer) for 3 times, 1 ml high salt buffer (1XChIP buffer+350 mM NaCl) for 1 time, then eluted with 150 ul ChIP elution buffer at 65 °C for 30  min with rotation.   6 ul 5 M NaCl and 2 ul Proteinase K #10012 was added to the eluted DNA. The DNA were incubated at 65°C for 2 hours to reserve crosslink. Then the DNA fragments were purified according to the manufacturer's instructions.
Libraries were prepared according to KAPA's instructions accompanying the DNA Sample Kit. Briefly, DNA was end-repaired using a combination of 3’-5’ exonuclease and polymerase. A protruding 3- 'A' base is introduced for ligation of Illumina's adapters which have a single 'T' base overhang at the 3’ end. After adapter ligation DNA was PCR amplified with primers and library fragments of ~ 380 bp (insert plus adaptor and PCR primer sequences) were band isolated from an agarose gel. The purified DNA was captured on an Illumina flow cell for cluster generation. Libraries were sequenced on the Illumina NovaSeq 6000 following the manufacturer's protocols.

value: Primary Skeletal Muscle Cells, ATCC, PCS-950-010, adapted to 10% FBS in DMEM

tag: chip antibodies

value: Histone H3 (D2B12) XP® Rabbit mAb (ChIP Formulated)#4620

tag: antibody vendor

value: CST

value: untreated


title: SUB235956, SUB235960, SUB235994, SUB235973 [s2a-hto]

status: Public on Oct 11 2023

type: SRA

city: Oklahoma City

first: Joel

last: Guthridge

state: OK

department: Arthritis and Clinical Immunology

country: USA

institute: Oklahoma Medical Research Foundation

library_source: transcriptomic

data_processing:
Basecalls performed using bcl2fastq version 2.20.0.422
RNA-seq reads were aligned and counted using CellRanger version 5.0.0 with default settings
CellRanger output was demultiplexed, concatenated, and analyzed using Seurat version 4.0.3
Genome_build: GRCh38 and mm9
Supplementary_files_format_and_content: FASTQs, MarketMatrix (.tsv and .mtx), and Seurat object (.Rdata)

molecule: total RNA

organism: Homo sapiens

source_name: CD2-depleted PBMC

extract_protocol:
Cells were stained as per the CITE-seq_and_Hashing_protocol_190213 protocol (found here: https://citeseq.files.wordpress.com/2019/02/cite-seq_and_hashing_protocol_190213.pdf).  Cells were pooled 4 or 5 samples to a pool and captured using the Chromium Single Cell 3' Reagent Kit v2 Revision F (found at https://support.10xgenomics.com/single-cell-gene-expression/index/doc/user-guide-chromium-single-cell-3-reagent-kits-user-guide-v2-chemistry)
Libraries were constructed as per the manufacturer's protocol in the Chromium Single Cell 3' Kit v2, Revision F.  In brief, captured mRNAs were reverse transcribed prior to the breaking of cell/gel bead droplets.  cDNAs were recovered and underwent amplification.  SPRI beads were used to clean the libraries and split them into gene expression and antibody-dependent libraries.  The GEX libraries underwent end repair, polyA tailing, and fragmentation prior to further size selection to extract 300-500 bp fragments and the ligation of sequencing adaptors; the ADT libraries were likewise purified and had sequencing adaptors added.

tag: tissue

value: CD2-depleted PBMC

tag: subject status

value: healthy controls and SLE patients


title: SUB235957, SUB236000, SUB235978, SUB235995 [s2b-hto]


title: Δckb2,no MMS, rep3

city: shanghai

first: Xianwei

last: Wu

address: No.725 South Wanping Road

department: Institute of Respiratory Diseases

country: China

institute: Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

data_processing:
Quality-filtered RNA-seq reads were aligned to the C.glabrata genome (http://www.candidagenome.org) by STAR software (version 2.7.4).
Gene expressions were obtained and normalized by StringTie (V2.1.2) and DESeq2 (V1.20).
Significantly expressed genes were screened based on a 2-fold cut-off and p-value < 0.05.
Assembly: Candida glabrata CBS138 genome
Supplementary files format and content: tab-delimited text files include gene count values for each Sample

organism: Nakaseomyces glabratus

growth_protocol: The WT , Δckb1 and Δckb2 strains were inoculated in YPD media and grown to saturation overnight. Cells were diluted to an OD600 of 0.1 and recovered to log phase for 4 hours shaking at 30°.

extract_protocol:
Total RNA was extracted by the acid phenol method. Three biological replicates were performed per condition. RNA was frozen at -80℃ and sent to Shanghai Majorbio Bio-pharm Technology Co., Ltd (Shanghai, China) for further sequencing by Illumina novaseq6000 PE150.
RNA libraries for RNA-seq were prepared using Illumina NovaSeq Reagent Kit following manufacturer's protocols.

treatment_protocol: Log-phase cultures of WT , Δckb1 and Δckb2 strains were either treated with 0.01% MMS for 1 h, or left untreated.

tag: cell line

tag: cell type

value: Yeast cells

tag: genotype

value: CgCKB2 knockdown

tag: treatment

tag: time


title: Vehicle - Statin Replicate 1

city: East Lansing

first: Rance

last: Nault

state: United States

address: 1355 Bogue St. B403

department: Department of Pharmacology and Toxicology

institute: Michigan State University

library_source: transcriptomic single cell

data_processing:
Following sequencing quality control, CellRanger v3.0.2 (10X Genomics) was used to align reads to a custom reference genome which included introns and exons to consider pre-mRNA and mature mRNA present in the nuclei.
Raw counts were further analysed using Seurat v4.0.0. Each sample was filtered for (i) genes expressed in at least 3 nuclei, (ii) nuclei which express at least 100 genes, and (iii) ≤1% mitochondrial genes.
Assembly: mm10
Supplementary files format and content: Processed data files for individual sample are CellRanger filtered_feature_bc_matrix outputs which includes barcodes (barcodes.tsv.gz),  features (features.tsv.gz), and the matrix (matrix.mtx.gz).
Supplementary files format and content: RData file represents the full processed Seurat R data object generated using Seurat v4.0.0.

organism: Mus musculus

source_name: liver

extract_protocol:
Nuclei were isolated from frozen liver samples (~200mg) as previously described (dx.doi.org/10.17504/protocols.io.3fkgjkw). Briefly, livers were diced in EZ Lysis Buffer (Sigma-Aldrich), homogenized using a disposable dounce homogenizer, and incubated on ice for 5 minutes. The homogenate was filtered using a 70 μm cell strainer, transferred to microcentrifuge tube, and centrifuged at 500 x g and 4°C for 5 minutes. The supernatant was removed and fresh EZ lysis buffer was added for an additional 5 minutes on ice following by centrifugation at 500 x g and 4°C for 5 minutes. The nuclei pellet was washed twice in nuclei wash and resuspend buffer (1X PBS, 1% BSA, 0.2 U/μL RNAse inhibitor) with 5 minute incubations on ice. Following the washes, the nuclei pellet was resuspended in nuclei wash and resuspend buffer containing DAPI (10 μg/mL). The resuspended nuclei were filtered with 40 μm strainer and immediately underwent fluorescence activated cell sorting (FACS) using a BD FACSAria IIu (BD Biosciences, San Jose, CA) with 70 μm nozzle.
Libraries were prepared using the 10X Genomics Chromium Single Cell 3’ v3.1 kit (10X Genomics)

treatment_protocol: Male C57BL/6 mice either gavaged with sesame oil vehicle or 30 ug/kg TCDD every 4 days for 28 days and fed with either normal chow or chow laced with 500 mg/kg simvastatin beginning 3 days prior to first TCDD treatment.

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

value: Harlan Teklad

tag: feed catalog_no

tag: ad lib_feeding

value: Yes

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

value: Accustandard;Sigma-aldrich

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: toxic substance_lot

tag: toxic substance_storage

value: Room temperature;4C

tag: vehicle substance

value: NCIT_C66537;animal feed

tag: vehicle substance_ontology_label

value: sesame oil;animal feed

tag: administration volume

value: 0.1;Not Applicable

tag: administration volume_unit

tag: administration volume_unit_label

value: milliliter;Not Applicable

tag: administration interval

value: 4;Not Applicable

tag: administration interval_unit

tag: administration interval_unit_label

value: day;Not Applicable

tag: administration number

value: 7;Not Applicable

tag: administration route

tag: administration route_ontology_label

value: oral gavage;animal feed

tag: dose unit

tag: dose unit_label

value: microgram per kilogram;milligram per kilogram per day

tag: time point

tag: time point_unit

tag: time point_unit_label

tag: euthanasia method


title: TCDD - Chow Replicate 3

tag: tissue

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

tag: water

tag: feed name

tag: feed description

tag: feed source

tag: feed catalog_no

tag: ad lib_feeding

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: toxic substance_lot

tag: toxic substance_storage

tag: vehicle substance


title: hsSKM_ChIP_UBE2A_rep2

city: Tianjin

institute: Tianjin University

library_source: genomic

molecule: genomic DNA

treatment_protocol: no treatment

tag: cell type

value: Primary Skeletal Muscle Cells, ATCC, PCS-950-010, adapted to 10% FBS in DMEM

tag: chip antibodies

tag: antibody vendor

value: invtrogen

tag: treatment

value: untreated


title: WT, MMS, rep3

tag: cell line

value: Yeast cells

tag: genotype

value: WT

value: 0.01% MMS for 1 hour

tag: time


title: WT, MMS, rep1


title: Vehicle - Statin Replicate 3

tag: tissue

tag: species

tag: species ontology_label

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

tag: preservation method

tag: metadata template_url

tag: biomaterial supplier

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

tag: light cycle

tag: cage type

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

value: Harlan Teklad

tag: feed catalog_no

tag: ad lib_feeding

value: Yes

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

value: Accustandard;Sigma-aldrich

value: Room temperature;4C

value: NCIT_C66537;animal feed

tag: vehicle substance_ontology_label

value: sesame oil;animal feed

tag: administration volume

value: 0.1;Not Applicable

tag: administration volume_unit

tag: administration volume_unit_label

value: milliliter;Not Applicable

tag: administration interval

value: 4;Not Applicable

tag: administration interval_unit

tag: administration interval_unit_label

value: day;Not Applicable

tag: administration number

value: 7;Not Applicable

tag: administration route

tag: administration route_ontology_label

value: oral gavage;animal feed

tag: dose unit

tag: dose unit_label

tag: time point

tag: time point_unit

tag: time point_unit_label

tag: euthanasia method


title: SUB235948, SUB235962, SUB235972, SUB235997 [s1b-hto]

tag: tissue

value: CD2-depleted PBMC

tag: subject status

value: healthy controls and SLE patients


title: SUB235957, SUB236000, SUB235978, SUB235995 [s2b-gex]


title: hsSKM_ChIP_Input_rep2

tag: cell type

value: Primary Skeletal Muscle Cells, ATCC, PCS-950-010, adapted to 10% FBS in DMEM

tag: treatment

value: untreated


title: Δckb1,no MMS, rep3

tag: cell line

value: Yeast cells

tag: genotype

value: CgCKB1 knockdown

tag: time


title: Vehicle - Statin Replicate 2

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

value: Harlan Teklad

tag: feed catalog_no

tag: ad lib_feeding

value: Yes

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: toxic substance_lot

tag: toxic substance_storage

tag: vehicle substance

tag: vehicle substance_ontology_label

tag: administration volume

tag: administration volume_unit

tag: administration volume_unit_label

tag: administration interval

tag: administration interval_unit

tag: administration interval_unit_label

value: microgram per kilogram;milligram per kilogram per day


title: hsSKM_ChIP_H3_rep2

tag: cell type

value: Primary Skeletal Muscle Cells, ATCC, PCS-950-010, adapted to 10% FBS in DMEM

tag: chip antibodies

value: Histone H3 (D2B12) XP® Rabbit mAb (ChIP Formulated)#4620

tag: antibody vendor

value: CST

tag: treatment

value: untreated


title: hsSKM_ChIP_Input_rep1


title: SUB235956, SUB235960, SUB235994, SUB235973 [s2a-gex]

tag: tissue

value: CD2-depleted PBMC

tag: subject status

value: healthy controls and SLE patients


title: SUB235948, SUB235962, SUB235972, SUB235997 [s1b-cite]


title: Δckb1,no MMS, rep1

tag: cell line

value: Yeast cells

tag: genotype

value: CgCKB1 knockdown

tag: time


title: Donor 2 - Lymphocytes T

city: Paris

first: Sebastien

last: Mella

address: 28 rue du Dr Roux

department: Immunology

country: France

institute: Institut Pasteur

data_processing:
Fastq files were obtained form Novogene and processed with with the cellranger-4.0.0 pipeline, and refdata-gex-GRCh38-2020-A as the reference genome
Supplementary_files_format_and_content: Hierarchical Data Format 5 File

source_name: Blood

extract_protocol:
Fresh PBMCs were obtained by gradient centrifugation of blood from two healthy donors.
RNA libraries were prepared for sequencing using standard Illumina protocols
cells were loaded on 10x Chromium controller using the Chromium NextGEM Single Cell 3’ Reagent Kits v3.1
Single cell RNA-Seq and CITE-seq (CG000206_ChromiumNextGEMSingleCell3'v3.1_CellSurfaceProtein_Rev D)

tag: donor

value: Donor 2

value: Blood

tag: disease

value: healthy

value: Lymphocytes T


title: Δckb2,no MMS, rep2

value: CgCKB2 knockdown


title: Vehicle - Chow Replicate 3

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

tag: feed catalog_no

tag: ad lib_feeding

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

value: Accustandard;Sigma-aldrich

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: toxic substance_lot

tag: toxic substance_storage

value: Room temperature;4C

tag: vehicle substance

value: NCIT_C66537;animal feed

tag: vehicle substance_ontology_label

value: sesame oil;animal feed

tag: administration volume

value: 0.1;Not Applicable

value: milliliter;Not Applicable

value: 4;Not Applicable

value: day;Not Applicable

tag: administration number

value: 7;Not Applicable

tag: administration route

tag: administration route_ontology_label

value: oral gavage;animal feed

tag: dose unit

tag: dose unit_label

tag: time point

tag: time point_unit

tag: time point_unit_label

tag: euthanasia method


title: SUB235956, SUB235960, SUB235994, SUB235973 [s2a-cite]

tag: tissue

value: CD2-depleted PBMC

tag: subject status

value: healthy controls and SLE patients


title: TCDD - Chow Replicate 2

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

tag: bedding

tag: water

tag: feed name

tag: feed description

tag: feed source

value: Harlan Teklad

tag: feed catalog_no

tag: ad lib_feeding

value: Yes

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: administration volume_unit

tag: administration volume_unit_label

tag: administration interval

tag: administration interval_unit

tag: administration interval_unit_label

value: microgram per kilogram;milligram per kilogram per day


title: Donor 2 - PBMC Ab capture

description: Cell surface marker

data_processing:
Library strategy: CITE-seq
Fastq files were obtained form Novogene and processed with with the cellranger-4.0.0 pipeline, and refdata-gex-GRCh38-2020-A as the reference genome
Supplementary_files_format_and_content: Hierarchical Data Format 5 File

tag: donor

value: Donor 2

tag: tissue

value: Blood

tag: disease

value: healthy

tag: cell type

value: PBMC Ab capture


title: TCDD - Chow Replicate 1

tag: species

tag: species ontology_label

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

tag: preservation method

tag: metadata template_url

tag: biomaterial supplier

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

tag: feed catalog_no

tag: ad lib_feeding

tag: toxic substance

tag: toxic substance_ontology_label

value: Accustandard;Sigma-aldrich

tag: toxic substance_lot

tag: toxic substance_storage

value: Room temperature;4C

tag: vehicle substance

value: NCIT_C66537;animal feed

tag: vehicle substance_ontology_label

value: sesame oil;animal feed

tag: administration volume

value: 0.1;Not Applicable

value: milliliter;Not Applicable

value: 4;Not Applicable

value: day;Not Applicable

tag: administration number

value: 7;Not Applicable

tag: administration route

tag: administration route_ontology_label

value: oral gavage;animal feed

tag: dose unit

tag: dose unit_label

tag: time point

tag: time point_unit

tag: time point_unit_label

tag: euthanasia method


title: hsSKM_ChIP_UBE2A_rep1

tag: cell type

value: Primary Skeletal Muscle Cells, ATCC, PCS-950-010, adapted to 10% FBS in DMEM

tag: chip antibodies

tag: antibody vendor

value: invtrogen

tag: treatment

value: untreated


title: SUB235948, SUB235962, SUB235972, SUB235997 [s1b-gex]

tag: tissue

value: CD2-depleted PBMC

tag: subject status

value: healthy controls and SLE patients


title: Donor 2 - PBMC Gene Expression

tag: donor

value: Donor 2

value: Blood

tag: disease

value: healthy

value: PBMC Gene Expression


title: WT, no MMS, rep3

tag: cell line

value: Yeast cells

tag: genotype

value: WT

tag: time


title: WT, no MMS, rep2


title: SUB235950, SUB235969, SUB235993, SUB235954 [s1a-cite]


title: Dot1l_WT_AT2

city: Philadelphia

first: Michael

middle: Patrick

last: Morley

state: PA

address: 3400 Civic Center Blvd, Bldg 421

department: Penn Cardiovascular Institute

institute: Perelman School of Medicine at the University of Pennsylvania

description: 10x Genomics

data_processing:
The demultiplexing, barcoded processing, gene counting were made using the STARSolo 2.7.9a and downstream analysis performed using Seurat v4
Assembly: mm39

source_name: Lung

extract_protocol:
Target cells were FACS sorted and were loaded onto the 10x Chromium (10X Genomics) aiming for 10,000 cells per sample.
Libraries were prepared according to the manufacturer’s protocol using Chromium Single Cell 3’ v2 chemistry.

treatment_protocol: YFP+ cells were collected from day 14 post-influenza injury 2 weeks after tamoxifen induction

value: Epithelial cells  Epithelial cells  Epithelial cells

value: Lung

value: Sftpc-creERT2; R26R_EYFP

value: 14 day post-influenza injury

value: YFP+ cells


title: Vehicle - Chow Replicate 1

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

value: Harlan Teklad

tag: feed catalog_no

tag: ad lib_feeding

value: Yes

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

value: Accustandard;Sigma-aldrich

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: toxic substance_lot

tag: toxic substance_storage

value: Room temperature;4C

tag: vehicle substance

value: NCIT_C66537;animal feed

tag: vehicle substance_ontology_label

value: sesame oil;animal feed

tag: administration volume

value: 0.1;Not Applicable

tag: administration volume_unit

tag: administration volume_unit_label

value: milliliter;Not Applicable

tag: administration interval

value: 4;Not Applicable

tag: administration interval_unit

tag: administration interval_unit_label

value: day;Not Applicable

tag: administration number

value: 7;Not Applicable

tag: administration route

tag: administration route_ontology_label

value: oral gavage;animal feed

tag: dose unit

value: microgram per kilogram;milligram per kilogram per day


title: Dot1lKO_AT2

description: 10x Genomics

tag: cell type

value: Epithelial cells  Epithelial cells  Epithelial cells

tag: tissue

value: Lung

tag: genotype

value: Sftpc-creERT2; Dot1l fl/fl; R26R_EYFP

tag: treatment

value: 14 day post-influenza injury

value: YFP+ cells


title: Vehicle - Chow Replicate 2

value: liver

tag: species

tag: species ontology_label

value: Mus musculus

tag: organ

tag: organ ontology_label

tag: mouse strain

tag: mouse strain_ontology_label

tag: age

tag: age unit

tag: age unit_label

value: day

tag: preservation method

value: Snap Frozen

value: Illumina NovaSeq 6000

tag: metadata template_url

tag: biomaterial supplier

value: Charles Rivers Laboratories

tag: acclimation period

tag: acclimation period_unit

tag: acclimation period_unit_label

tag: average vivarium_temperature

tag: average vivarium_temperature_unit

tag: average vivarium_temperature_unit_label

value: degree celsius

tag: average vivarium_humidity

tag: average vivarium_humidity_unit

tag: average vivarium_humidity_unit_label

value: percent

tag: light cycle

tag: cage type

value: Innovive cage

tag: bedding

value: ALPHA-dri (Shepherd Specialty Papers)

tag: water

value: Aquavive water (Innovive)

tag: feed name

value: Harlan Teklad 22/5 Rodent Diet 8640

tag: feed description

tag: feed source

value: Harlan Teklad

tag: feed catalog_no

tag: ad lib_feeding

value: Yes

tag: toxic substance

tag: toxic substance_ontology_label

tag: cas number

tag: smile string

tag: formula

tag: toxic substance_molecular_weight

tag: toxic substance_vendor

tag: toxic substance_catalog_number

tag: toxic substance_purity

tag: toxic substance_lot

tag: toxic substance_storage

tag: dose unit_label

tag: time point

tag: time point_unit

tag: time point_unit_label

tag: euthanasia method


title: C2C12 cells,  4-octyl itaconate(OI), Day7-1  [rep2]

status: Public on Oct 10 2023

city: Jinan

first: Dawei

last: Wang

state: Shandong

address: No. 324, Road Jing Wu Wei Qi

institute: Shandong Provincial Hospital Affiliated to Shandong First Medical University

data_processing:
Sequence reads were trimmed for adapter,reads containing ploy-N and low quality reads using cutadapt V 2.7 (parameter- minimum-length > 20, error-rate < 0.1)
Trimmed sequence reads were mapped to mm10 using hisat v2.1.0
Read count extraction and normalization were performed using StringTie v1.3.3b and ballgown
Assembly: mm10
Supplementary files format and content: tab-delimited text files include FPKM values for each Sample

growth_protocol: C2C12 mouse myoblast cells were maintained in DMEM supplemented with 10% fetal bovine serum (FBS) and antibiotics in humidified atmosphere with 5% CO2 at 37C

extract_protocol:
Total RNA was extracted with RNAiso Plus according to the manufacturer’s protocol. Total RNA extracted from C2C12 cells treated with 25 μmol/L OI and control group with induced differentiation for 7 d.
RNA libraries for RNA-seq were prepared using TruseqTM RNA sample prep Kit following manufacturer's protocols.

treatment_protocol: To induce myoblast differentiation in vitro, C2C12 cells were first grown to 80% density in high-glucose DMEM containing 10% fetal bovine serum and 1% penicillin/streptomycin, and then transferred to high-glucose DMEM containing supplemented 2% horse serum and 1% penicillin/streptomycin with or without OI treatment at 37 ° C with 5% CO2.

tag: cell line

tag: cell type

value: mouse myoblast cells

tag: genotype

value: WT

tag: treatment

value: 4-octyl itaconate treatment

value: Myogenic differentiation


title: Donor 1 - PBMC Ab capture

description: Cell surface marker

tag: donor

value: Donor 1

tag: tissue

value: Blood

tag: disease

value: healthy

value: PBMC Ab capture


title: C2C12 cells,  4-octyl itaconate(OI), Day7-2  [rep2]


title: C2C12 cells,  Day7-3 [rep2]


title: Donor 1 - PBMC Gene Expression

value: PBMC Gene Expression


title: SUB235950, SUB235969, SUB235993, SUB235954 [s1a-hto]

value: CD2-depleted PBMC

tag: subject status

value: healthy controls and SLE patients


title: C2C12 cells,  4-octyl itaconate(OI), Day7-3 [rep2]


title: Donor 1 - Lymphocytes T

value: Lymphocytes T


title: C2C12 cells,  Day7-2 [rep2]


title: Δckb1,no MMS, rep2

value: Yeast cells

value: CgCKB1 knockdown

value: untreated

tag: time


title: C2C12 cells,  4-octyl itaconate(OI), Day7-3

tag: differentiation status


title: SUB235950, SUB235969, SUB235993, SUB235954 [s1a-gex]


title: C2C12 cells,  Day7-1 [rep2]


title: C2C12 cells,  Day7-1


title: Δckb2,no MMS, rep1

value: CgCKB2 knockdown


title: C2C12 cells,  4-octyl itaconate(OI), Day7-1


title: C2C12 cells,  Day7-2


title: WT, no MMS, rep1


title: C2C12 cells,  Day7-3


title: Root midsection, P limiting, rep 3 [MLM3]

city: Davis

first: Siobhan

last: Brady

state: California

address: One Shields

department: Plant Biology and Genome Center

institute: UC Davis

data_processing:
A custom perl script partitioned the reads into individual libraries based on the barcode and trimmed reads. FastQC (https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) was used to check the quality of each sequenced library.
Five of the 32 libraries were excluded from analysis due to poor sequence quality.
Reads were aligned to the S. lycopersicum reference transcriptome ITAG 3.1) (Fernandez-Pozo et al. 2014) with bowtie 1.2.2 (Langmead, 2010) (http://bowtie-bio.sourceforge.net/index.shtml).
Reads were aggregated in count tables using a custom script . Differential gene analysis was performed on normalized read counts using the method of trimmed mean of M-values (TMM) with the calcNormFactors function in edgeR (Robinson et al., 2010) and the limma (Ritchie et al., 2015) Bioconductor packages in R.
A linear model was used to determine the effects of developmental stage and phosphate by developmental state on differential gene expression. S. lycopersicum and S. pennellii were analyzed separately but used the same pipelines and thresholds for analysis. Multiple testing correction was performed using the ashR package in R. P-values are set below 0.05.
Assembly: ITAG 3.1

organism: Solanum lycopersicum

source_name: 35S:TRAP construct-containing tomato seedlings

growth_protocol: Plants were grown for 8 to 10 days after germination in a growth chamber at 25C in 12H light and 12H night on plant growth media similar to MS without the addition of phosphate or with phosphate

extract_protocol:
Total RNA was extracted using the Direct-zol RNA Miniprep kit (ZYMO).
RNA libraries were prepared using Breath Adapter Directional sequencing (BrAD-seq) a strand-specific 3-prime RNA-seq library prep protocol
Libraries were pooled, barcoded, and submitted to the UC Davis DNA Technologies Core and were sequenced on Illumina HiSeq2000 SR50

tag: cultivar

value: cv M82

tag: age

value: 8 to 10 days-after germination

value: approximately 2 cm of tissue halfway between the root-shoot junction and the root tip

value: Limiting phosphate


title: Root midsection, P limiting, rep 4 [MLM4]


title: Root midsection, P limiting, rep 2 [MLM2]


title: Root tips, P limiting, rep 2 [MLT2]

value: 1 cm segment from the root tip


title: Root midsection, P sufficient, rep 4 [MSM4]

value: Sufficient phosphate


title: Root tips, P sufficient, rep 1 [MST1]


title: Root midsection, P sufficient, rep 3 [MSM3]


title: Root tips, P limiting, rep 3 [MLT3]


title: HFF_16_glu_starv_3

type: RNA

city: Rehovot

first: Ester

last: Feldmesser

state: Rehovot

address: POB 25

department: Life Science Core Facilities

country: Israel

institute: Weizmann Institute

description: Gene expression data

scan_protocol: According to Affymetrix standard protocols, using Affymetrix GeneChip 3000 7G plus scanner

data_processing: RMA was carried out using Partek Genomic Suite 6.5 (Inc. St. Charles, MO; www.partek.com)

label: biotin

growth_protocol: Cells were grown in Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids (01-040-1A, Biological Industries, Israel) supplemented with 2.6 mM L-Glutamine, Ampicillin and Streptomycin and 15% FBS. For routine culturing, cell were split 1:3 or 1:4 every 3-4 days.

extract_protocol: RNA was extracted with Qiazol (Qiagen, Germany)

treatment_protocol: Prior to a typical experiment, 125,000-140,000 cells were seeded in a 6 cm dish and cultures were grown for 44-46 hours prior to transfection

value: Human foreskin fibroblasts (HFF) (AG14608)

value: 16 hours starved


title: HFF_48_glu_starv_3

description: Gene expression data

hyb_protocol: According to Affymetrix standard protocols

value: 48 hours starved


title: HFF_48_glu_starv_2

description: Gene expression data

label_protocol: According to Affymetrix standard protocols


title: HFF_48_glu_starv_1

description: Gene expression data


title: HFF_16_glu_starv_1

description: Gene expression data


title: HFF_wo_starv_3

description: Gene expression data

value: control (not starved)


title: C2C12 cells,  4-octyl itaconate(OI), Day7-2

value: mouse myoblast cells

value: 4-octyl itaconate treatment

value: Myogenic differentiation


title: HFF_16_glu_starv_2

description: Gene expression data


title: Root midsection, P sufficient, rep 2 [MSM2]


title: HFF_wo_starv_1

description: Gene expression data


title: Root midsection, P sufficient, rep 1 [MSM1]


title: Root tips, P sufficient, rep 4 [MST4]


title: HFF_wo_starv_2

description: Gene expression data


title: Root tips, P sufficient, rep 3 [MST3]


title: Root tips, P sufficient, rep 2 [MST2]


title: Root midsection, P limiting, rep 1 [MLM1]


title: Root tips, P limiting, rep 4 [MLT4]


title: Gen14_3

city: Guangzhou

first: Liting

last: Chen

state: Guangdong

address: 1838 North Guangzhou Blvd.

department: Division of Nephrology

institute: Nanfang Hospital, Southern Medical University

data_processing:
Illumina Casava 2.19 software used for basecalling
Raw data (raw reads) of fastp format were firstly processed through in-house perl scripts..In this step, clean data (clean reads) were obtained by removing reads containing adapter, reads containing ploy-N and low quality reads from raw data. At the same time, Q20, Q30 and GC content the clean data were calculated. All the downstream analyses were based on the clean data with high quality.
Reference genome and gene model annotation files were downloaded from genome website directly. Index of the reference genome was built using Hisat2 v2.0.5 and paired-end clean reads were aligned to the reference genome using Hisat2 v2.0.5.
featureCounts v1.5.0-p3 was used to count the reads numbers mapped to each gene.
Differential expression analysis of two conditions/groups (two biological replicates per condition) was performed using the DESeq2 R package (1.20.0).
Assembly: AmexG_v3.0.0
Supplementary files format and content: tab-delimited text files include FPKM values and gene count for each Sample

organism: Ambystoma mexicanum

source_name: kidney

extract_protocol:
Total RNA was isolated using TRIzol (Invitrogen) according to the manufacturer’s instructions.
RNA libraries for RNA-seq were prepared using NEBNext® Ultra™ RNA Library Prep Kit for Illumina® following manufacturer's protocols.

value: kidney

value: gentamicin


title: Gen14_1


title: Control1

value: untreated


title: Control3


title: Control2


title: mTeSR, rep 2

city: Houston

first: Aryeh

last: Warmflash

state: TX

address: 6100 Main St

institute: Rice University

data_processing:
To quantify the abundance of transcripts for each sample, Salmon v1.8.0 was used (Rob Patro et al.). To align our data, we used the human transcriptome (GRCh38) index for salmon, with salmon index using the selective alignment method (salmon_sa_index:default in http://refgenomes.databio.org/v3/genomes/splash/2230c535660fb4774114bfa966a62f823fdb6d21acf138d4). We quantified transcripts with Salmon using the -l A flag to infer the library type (paired-end) automatically and the –validateMappings -o flag to use the mapping-based mode. The resulting datasets were then processed using the tximeta2 package in R (Love et al., 2020), and the counts matrix was exported for downstream analyses in MATLAB
Assembly: GRCh38
Supplementary files format and content: Excel file with the counts matrix for each replicate in each sample, obtained by processing the Salmon output with the tximeta2 package in R.

growth_protocol: hPSCs were grown in the chemically defined medium mTeSR1 in tissue culture dishes and kept at 370C, 5% CO2

extract_protocol:
Total RNA was collected with the Invitrogen RNAqueous-Micro Total RNA Isolation Kit. Processed RNA was stored at −80 ̊C, and RNA integrity was checked by Nanodrop, agarose gel electrophoresis, and qPCR and the Agilent 2100 system. Sequencing was performed by Novogene Co. using the Illumina paired-end 150 platform (HiSeq2500). Another biological repeat was performed using the same protocol
Messenger RNA was purified from total RNA using poly-T oligo-attached magnetic beads. After fragmentation, the first strand cDNA was synthesized using random hexamer primers followed by the second strand cDNA synthesis. The library was ready after end repair, A-tailing, adapter ligation, size selection, amplification, and purification. The library was checked with Qubit and real-time PCR for quantification and bioanalyzer for size distribution detection. Quantified libraries will be pooled and sequenced on Illumina platforms, according to effective library concentration and data amount.

treatment_protocol: hPSCs were seeded at the density 200k per well in a 12-well plate 24 hours before treatment, and were kept in mTeSR1. hPSCs were all grown in mTeSR1 for the length of the protocol with the addition of the recombinant proteins or small molecules when specified: untreated pluripotent cells grown in mTeSR1, hPSCs treated with WNT3a (300ng/ml) in mTeSR1 for 6 hours, hPSCs treated with WNT3a (300ng/ml)  in mTeSR1 for 18 hours or hPSCs treated with CHIR (8uM)  in mTeSR1 for 6 hours.

value: hPSCs

value: WT


title: WNT 6h, rep 2

value: mTeSR1 + 300ng/ml WNT3A for 6 hours


title: CHIR 18h, rep 2, rep 2

value: mTeSR1 + 8uM CHIR99021 for 18 hours


title: WNT 18h, rep 2

value: mTeSR1 + 300ng/ml WNT3A for 18 hours


title: CHIR 18h, rep 2


title: CHIR 6h, rep 2

value: mTeSR1 + 8uM CHIR99021 for 6 hours


title: WNT 18h, rep 1


title: WNT 6h, rep1


title: mTeSR, rep 1

description: mTeSR


title: CHIR 6h, rep 1


title: TAX65 UTUC patient tumor sample

first: Guerric

last: Gilbert

address: 11/13 rue Pierre et Marie Curie

institute: Institut Curie

data_processing:
Input sequence reads adapters were removed with Atropos
Reads were aligned to the reference genome using STAR 2.6.1a
Reads count extraction was performed using STAR
Final count table was normalized for analysis using log2(transcripts per million + 1)
Assembly: Hg19
Supplementary files format and content: Normalized count table file for all 87 samples : TAXOVES_87samples_log2TPM_normalized_count_table_3TagRNAseq.csv
Supplementary files format and content: Table of correspondance between gene ENSEMBL ID and gene symbol : Gene_annotation_file.csv

source_name: Upper tract Urothelial carcinoma

extract_protocol:
Maxwell RSC RNA FFPE Kit
Lexogen QuantSeq 3’ Seq FWD

tag: patient id

tag: sample id

value: Upper tract Urothelial carcinoma

tag: tumor stage

tag: tumor grade

value: High grade

tag: tumor histological_subtype

value: Squamous

tag: tumor localization

value: Ureter

tag: sample consensus_molecular_subtype

value: LumP


title: TAX70 UTUC patient tumor sample

value: Conventional

value: Renal pelvis


title: TAX67 UTUC patient tumor sample


title: TAX69 UTUC patient tumor sample

value: Ba/Sq


title: TAX66 UTUC patient tumor sample


title: TAX68 UTUC patient tumor sample


title: TAX71 UTUC patient tumor sample


title: TAX60 UTUC patient tumor sample 2


title: TAX64 UTUC patient tumor sample


title: TAX63 UTUC patient tumor sample 2


title: TAX61 UTUC patient tumor sample


title: TAX58 UTUC patient tumor sample


title: TAX59 UTUC patient tumor sample


title: TAX60 UTUC patient tumor sample 1


title: TAX56 UTUC patient tumor sample

value: Low grade


title: TAX54 UTUC patient tumor sample


title: TAX53 UTUC patient tumor sample


title: TAX52 UTUC patient tumor sample 2


title: TAX52 UTUC patient tumor sample 1

value: LumU


title: TAX48 UTUC patient tumor sample


title: TAX51 UTUC patient tumor sample

value: LumNS


title: TAX47 UTUC patient tumor sample


title: TAX44 UTUC patient tumor sample


title: TAX45 UTUC patient tumor sample


title: TAX62 UTUC patient tumor sample


title: TAX63 UTUC patient tumor sample 1


title: TAX43 UTUC patient tumor sample

value: Poorly differentiated


title: Root tips, P limiting, rep 1 [MLT1]

value: cv M82

value: 8 to 10 days-after germination

value: 1 cm segment from the root tip

value: Limiting phosphate


title: TAX41 UTUC patient lymphe node sample 2

value: Lymph node


title: TAX41 UTUC patient lymph node sample 1

value: Upper tract Urothelial carcinoma

value: Micropapillary


title: TAX39 UTUC patient tumor sample

value: High grade


title: TAX35 UTUC patient tumor sample

value: Ureter


title: TAX34 UTUC patient tumor sample 2

value: LumP


title: TAX31 UTUC patient tumor sample

value: Conventional


title: TAX50 UTUC patient tumor sample

value: Renal pelvis


title: TAX36 UTUC patient lymph node sample


title: TAX37 UTUC patient tumor sample

value: Squamous

value: Ba/Sq


title: TAX41 UTUC patient tumor sample 1

value: LumU


title: TAX30 UTUC patient tumor sample

value: Low grade


title: TAX32 UTUC patient tumor sample 2

value: Stroma-rich


title: TAX29 UTUC patient tumor sample 1


title: TAX33 UTUC patient tumor sample


title: TAX29 UTUC patient tumor sample 2


title: TAX41 UTUC patient tumor sample 2


title: TAX42 UTUC patient tumor sample


title: TAX29 UTUC patient tumor sample 3


title: TAX32 UTUC patient tumor sample 1


title: TAX34 UTUC patient tumor sample 1


title: TAX49 UTUC patient tumor sample

value: LumNS


title: TAX26 UTUC patient tumor sample


title: TAX22 UTUC patient tumor sample 2


title: TAX24 UTUC patient tumor sample

value: Nested


title: TAX23 UTUC patient tumor sample


title: TAX38 UTUC patient tumor sample


title: TAX20 UTUC patient tumor sample 1


title: TAX20 UTUC patient tumor sample 2


title: TAX18 UTUC patient tumor sample


title: TAX17 UTUC patient tumor sample


title: TAX14 UTUC patient tumor sample


title: TAX28 UTUC patient tumor sample


title: TAX22 UTUC patient tumor sample 3


title: TAX21 UTUC patient tumor sample


title: TAX15 UTUC patient tumor sample


title: TAX19 UTUC patient tumor sample


title: TAX27 UTUC patient tumor sample


title: TAX14 UTUC patient lymph node sample


title: TAX12 UTUC patient tumor sample


title: TAX07 UTUC patient tumor sample


title: TAX06 UTUC patient tumor sample


title: TAX13 UTUC patient tumor sample


title: TAX16 UTUC patient tumor sample


title: TAX09 UTUC patient tumor sample


title: TAX08 UTUC patient tumor sample


title: TAX25 UTUC patient tumor sample


title: TAX05 UTUC patient tumor sample 1


title: TAX05 UTUC patient tumor sample 3

value: Sarcomatoid


title: TAX04 UTUC patient tumor sample 1


title: TAX04 UTUC patient tumor sample 2


title: TAX03 UTUC patient tumor sample 2


title: TAX22 UTUC patient tumor sample 1


title: TAX17 UTUC patient lymph node sample


title: TAX03 UTUC patient tumor sample 1


title: TAX11 UTUC patient tumor sample


title: TAX02 UTUC patient tumor sample


title: TAX05 UTUC patient tumor sample 2

value: Poorly differentiated


title: TAX01 UTUC patient tumor sample 1


title: Pool_11, PBMC, snATACseq

city: Atlanta

first: Greg

last: Gibson

state: GA

address: North Ave NW

institute: Georgia Institute of Technology

description:
1 male, 2 female
10x Genomics

data_processing:
The demultiplexing, barcoded processing, gene counting and aggregation were made using Cell Ranger software cellranger-arc-2.0.0 for all samples (cellranger-arc-2.0.1 for Sample_0) (https://support.10xgenomics.com/single-cell-multiome-atac-gex/software/pipelines/latest/what-is-cell-ranger-arc
Assembly: hg38
Supplementary files format and content: Tab-separated values files and matrix files

source_name: PBMC

extract_protocol:
Frozen PBMC
snRNA-seq
snATAC-seq

tag: cell type

value: PBMC

tag: number of_donors


title: TAX01 UTUC patient lymph node sample

value: Upper tract Urothelial carcinoma

value: Lymph node


title: TAX01 UTUC patient tumor sample 2

value: High grade


title: Pool_10, PBMC, snATACseq

description:
1 male, 2 female
10x Genomics


title: Pool_8, PBMC, snATACseq

description:
2 male
10x Genomics


title: Pool_5, PBMC, snATACseq

description:
1 male, 1 female
10x Genomics


title: Pool_6, PBMC, snATACseq

description:
2 male, 1 female
10x Genomics


title: Pool_11, PBMC, snRNAseq

description:
1 male, 2 female
10x Genomics


title: Pool_8, PBMC, snRNAseq

description:
2 male
10x Genomics


title: Pool_4, PBMC, snATACseq

description:
2 male, 1 female
10x Genomics


title: Sample_0, PBMC, snATACseq

description:
male
10x Genomics


title: Pool_10, PBMC, snRNAseq

description:
1 male, 2 female
10x Genomics


title: Pool_7, PBMC, snRNAseq

description:
1 male, 2 female
10x Genomics


title: Pool_5, PBMC, snRNAseq

description:
1 male, 1 female
10x Genomics


title: Pool_6, PBMC, snRNAseq

description:
2 male, 1 female
10x Genomics


title: Pool_9, PBMC, snRNAseq

description:
2 male, 1 unknown
10x Genomics


title: Sample_0, PBMC, snRNAseq

description:
male
10x Genomics


title: Pool_4, PBMC, snRNAseq

description:
2 male, 1 female
10x Genomics


title: NoTreatment, NoTreatment, Screening plate 3, Well P24 [S4881Nr8_P24]

city: Göttingen

first: Christopher

last: Bruhn

address: Marie-Curie-Str. 7

country: Germany

institute: Evotec International GmbH

data_processing:
Transcriptomic profiling was performed in batches of 382 samples. Each batch contained 22 negative-control (i.e. DMSO-treated) samples, and 15 blocks of compound-treated samples. Every block included 8 compound concentrations, each in triplicate.
Reads were mapped to the human genome (genome-build GRCh38.p13 – accession GCA_000001405.28) using STAR (version 2.7.9a).
Multi-mapped reads, reads with mapping to inter-genic regions (with respect to Ensembl gene annotation information version 104) and reads with ambiguous mapping location (i.e. location associated with more than one gene) were discarded, and UMI-based deduplication was performed.
Sequencing files were demultiplexed and barcodes were stripped.
Assembly: GRCh38.p13 – accession GCA_000001405.28
Supplementary files format and content: processed_data_counts.txt: RNA unique moecular identifier (UMI) counts per gene. The column EnsemblID provides the unique gene identifier. One column is included per sample with column names matching the column "description" in the table "SAMPLES".

molecule: polyA RNA

source_name: hiPSC-CM

growth_protocol: human iPSC-derived cardiomyocytes (hiPSC-CMs) were seeded in 384-well plates (Corning® Cat. No.: 3764) pre-coated with a 0.1 µg/mL fibronectin solution (Sigma Cat. No. F1141) in phosphate buffered saline (PBS) containing Mg2+ and Ca2+. Fibronectin pre-coated plates were incubated at 37°C for 3 h (5% CO2, 95% humidity), after which the coating was carefully removed using an automated liquid handling robot (Bravo Agilent). Subsequently, hiPSC-CMs were seeded at 10,000 cells/well and cultured for 10 days in CD-4 media. Media was initially refreshed 24 h post-seeding and then, every 48 h thereafter while the cells were in culture.

extract_protocol:
High-throughput transcriptomics was performed using Evotec’s (semi)-automated ScreenSeqTM platform. Cell lysis was performed in a 384-well plate format followed by well-specific labeling of samples.
Plate RNASeq of polyA RNA (ScreenSeqTM); Purified mRNAs were labeled with a unique molecular identifier (UMI). After pooled cDNA synthesis, adapters containing Illumina’s unique dual indexes were attached for final library preparation and sequenced on a NovaSeq 6000 system.

treatment_protocol: All compounds were dissolved in 100% dimethylsulfoxide (DMSO) (stock solutions). The stock solutions were further diluted in CD-4 media and cells were dosed in triplicate at an eight-point dose response range using a half-log dilution series to achieve a final DMSO concentration of 0.5% (v/v). Vehicle controls were dosed with 0.5% (v/v) DMSO, while positive controls were dosed with sunitinib, a functional and structural cardiotoxicant.

tag: cell line

value: hiPSC-CM

tag: genotype

value: WT

tag: treatment

value: NoTreatment, NoTreatment


title: Sunitinib, Con1, Screening plate 3, Well M24 [S4881Nr8_M24]

value: Sunitinib, Con1


title: Sunitinib, Con1, Screening plate 3, Well O24 [S4881Nr8_O24]


title: Sunitinib, Con1, Screening plate 3, Well N24 [S4881Nr8_N24]


title: NoTreatment, NoTreatment, Screening plate 3, Well P1 [S4881Nr8_P1]


title: Sunitinib, Con2, Screening plate 3, Well N23 [S4881Nr8_N23]

value: Sunitinib, Con2


title: Sunitinib, Con2, Screening plate 3, Well O23 [S4881Nr8_O23]


title: Sunitinib, Con2, Screening plate 3, Well M23 [S4881Nr8_M23]


title: Sunitinib, Con3, Screening plate 3, Well O22 [S4881Nr8_O22]

value: Sunitinib, Con3


title: Pool_7, PBMC, snATACseq

description:
1 male, 2 female
10x Genomics

tag: tissue


title: Pool_9, PBMC, snATACseq

description:
2 male, 1 female
10x Genomics


title: Sunitinib, Con3, Screening plate 3, Well N22 [S4881Nr8_N22]

tag: time


title: Sunitinib, Con3, Screening plate 3, Well M22 [S4881Nr8_M22]


title: Sunitinib, Con4, Screening plate 3, Well O21 [S4881Nr8_O21]

value: Sunitinib, Con4


title: Sunitinib, Con5, Screening plate 3, Well O20 [S4881Nr8_O20]

value: Sunitinib, Con5


title: Sunitinib, Con5, Screening plate 3, Well N20 [S4881Nr8_N20]


title: Sunitinib, Con4, Screening plate 3, Well M21 [S4881Nr8_M21]


title: Sunitinib, Con4, Screening plate 3, Well N21 [S4881Nr8_N21]


title: Sunitinib, Con6, Screening plate 3, Well O19 [S4881Nr8_O19]

value: Sunitinib, Con6


title: Sunitinib, Con6, Screening plate 3, Well N19 [S4881Nr8_N19]


title: Sunitinib, Con6, Screening plate 3, Well M19 [S4881Nr8_M19]


title: Sunitinib, Con7, Screening plate 3, Well O18 [S4881Nr8_O18]

value: Sunitinib, Con7


title: Sunitinib, Con8, Screening plate 3, Well N17 [S4881Nr8_N17]

value: Sunitinib, Con8


title: Sunitinib, Con7, Screening plate 3, Well M18 [S4881Nr8_M18]


title: Sunitinib, Con8, Screening plate 3, Well O17 [S4881Nr8_O17]


title: Sunitinib, Con7, Screening plate 3, Well N18 [S4881Nr8_N18]


title: Sunitinib, Con8, Screening plate 3, Well M17 [S4881Nr8_M17]


title: Verapamil, Con1, Screening plate 3, Well N16 [S4881Nr8_N16]

value: Verapamil, Con1


title: Verapamil, Con1, Screening plate 3, Well O16 [S4881Nr8_O16]


title: Verapamil, Con1, Screening plate 3, Well M16 [S4881Nr8_M16]


title: Verapamil, Con2, Screening plate 3, Well O15 [S4881Nr8_O15]

value: Verapamil, Con2


title: Verapamil, Con2, Screening plate 3, Well N15 [S4881Nr8_N15]


title: Verapamil, Con3, Screening plate 3, Well O14 [S4881Nr8_O14]

value: Verapamil, Con3


title: Verapamil, Con2, Screening plate 3, Well M15 [S4881Nr8_M15]


title: Verapamil, Con3, Screening plate 3, Well N14 [S4881Nr8_N14]


title: Verapamil, Con3, Screening plate 3, Well M14 [S4881Nr8_M14]


title: Verapamil, Con4, Screening plate 3, Well O13 [S4881Nr8_O13]

value: Verapamil, Con4


title: Verapamil, Con5, Screening plate 3, Well O12 [S4881Nr8_O12]

value: Verapamil, Con5


title: Verapamil, Con5, Screening plate 3, Well M12 [S4881Nr8_M12]


title: Verapamil, Con4, Screening plate 3, Well M13 [S4881Nr8_M13]


title: Verapamil, Con5, Screening plate 3, Well N12 [S4881Nr8_N12]


title: Verapamil, Con4, Screening plate 3, Well N13 [S4881Nr8_N13]


title: Verapamil, Con6, Screening plate 3, Well O11 [S4881Nr8_O11]

value: Verapamil, Con6


title: Verapamil, Con6, Screening plate 3, Well M11 [S4881Nr8_M11]

value: hiPSC-CM


title: Sunitinib, Con5, Screening plate 3, Well M20 [S4881Nr8_M20]

value: WT


title: Verapamil, Con7, Screening plate 3, Well O10 [S4881Nr8_O10]

value: Verapamil, Con7


title: Verapamil, Con6, Screening plate 3, Well N11 [S4881Nr8_N11]


title: Verapamil, Con7, Screening plate 3, Well N10 [S4881Nr8_N10]


title: Verapamil, Con8, Screening plate 3, Well O9 [S4881Nr8_O9]

value: Verapamil, Con8


title: Verapamil, Con8, Screening plate 3, Well N9 [S4881Nr8_N9]


title: Verapamil, Con8, Screening plate 3, Well M9 [S4881Nr8_M9]


title: Sunitinib, Con1, Screening plate 3, Well M8 [S4881Nr8_M8]

value: Sunitinib, Con1


title: Sunitinib, Con2, Screening plate 3, Well N7 [S4881Nr8_N7]

value: Sunitinib, Con2


title: Sunitinib, Con3, Screening plate 3, Well N6 [S4881Nr8_N6]

value: Sunitinib, Con3


title: Sunitinib, Con3, Screening plate 3, Well M6 [S4881Nr8_M6]


title: Sunitinib, Con4, Screening plate 3, Well O5 [S4881Nr8_O5]

value: Sunitinib, Con4


title: Sunitinib, Con5, Screening plate 3, Well N4 [S4881Nr8_N4]

value: Sunitinib, Con5


title: Sunitinib, Con4, Screening plate 3, Well M5 [S4881Nr8_M5]


title: Sunitinib, Con5, Screening plate 3, Well O4 [S4881Nr8_O4]


title: Sunitinib, Con5, Screening plate 3, Well M4 [S4881Nr8_M4]


title: Sunitinib, Con1, Screening plate 3, Well O8 [S4881Nr8_O8]


title: Sunitinib, Con1, Screening plate 3, Well N8 [S4881Nr8_N8]


title: Sunitinib, Con6, Screening plate 3, Well O3 [S4881Nr8_O3]

value: Sunitinib, Con6


title: Sunitinib, Con6, Screening plate 3, Well M3 [S4881Nr8_M3]


title: Sunitinib, Con6, Screening plate 3, Well N3 [S4881Nr8_N3]


title: Verapamil, Con7, Screening plate 3, Well M10 [S4881Nr8_M10]


title: Sunitinib, Con7, Screening plate 3, Well O2 [S4881Nr8_O2]

value: Sunitinib, Con7


title: Sunitinib, Con8, Screening plate 3, Well N1 [S4881Nr8_N1]

value: Sunitinib, Con8


title: Sunitinib, Con8, Screening plate 3, Well O1 [S4881Nr8_O1]


title: Sunitinib, Con7, Screening plate 3, Well N2 [S4881Nr8_N2]


title: Lapatinib, Con1, Screening plate 3, Well K24 [S4881Nr8_K24]

value: Lapatinib, Con1


title: Lapatinib, Con1, Screening plate 3, Well L24 [S4881Nr8_L24]


title: Sunitinib, Con8, Screening plate 3, Well M1 [S4881Nr8_M1]


title: Sunitinib, Con2, Screening plate 3, Well O7 [S4881Nr8_O7]


title: Sunitinib, Con2, Screening plate 3, Well M7 [S4881Nr8_M7]


title: Lapatinib, Con2, Screening plate 3, Well K23 [S4881Nr8_K23]

value: Lapatinib, Con2


title: Sunitinib, Con7, Screening plate 3, Well M2 [S4881Nr8_M2]


title: Sunitinib, Con3, Screening plate 3, Well O6 [S4881Nr8_O6]


title: Lapatinib, Con1, Screening plate 3, Well J24 [S4881Nr8_J24]


title: Lapatinib, Con2, Screening plate 3, Well L23 [S4881Nr8_L23]


title: Lapatinib, Con2, Screening plate 3, Well J23 [S4881Nr8_J23]


title: Lapatinib, Con3, Screening plate 3, Well L22 [S4881Nr8_L22]

value: Lapatinib, Con3


title: Sunitinib, Con4, Screening plate 3, Well N5 [S4881Nr8_N5]


title: Lapatinib, Con3, Screening plate 3, Well J22 [S4881Nr8_J22]


title: Lapatinib, Con4, Screening plate 3, Well L21 [S4881Nr8_L21]

value: Lapatinib, Con4


title: Lapatinib, Con3, Screening plate 3, Well K22 [S4881Nr8_K22]


title: Lapatinib, Con4, Screening plate 3, Well K21 [S4881Nr8_K21]


title: Lapatinib, Con5, Screening plate 3, Well K20 [S4881Nr8_K20]

value: Lapatinib, Con5


title: Lapatinib, Con5, Screening plate 3, Well L20 [S4881Nr8_L20]

value: hiPSC-CM


title: Lapatinib, Con4, Screening plate 3, Well J21 [S4881Nr8_J21]

value: WT


title: Lapatinib, Con5, Screening plate 3, Well J20 [S4881Nr8_J20]


title: Lapatinib, Con6, Screening plate 3, Well L19 [S4881Nr8_L19]

value: Lapatinib, Con6


title: Lapatinib, Con6, Screening plate 3, Well K19 [S4881Nr8_K19]


title: Lapatinib, Con6, Screening plate 3, Well J19 [S4881Nr8_J19]


title: Lapatinib, Con7, Screening plate 3, Well K18 [S4881Nr8_K18]

value: Lapatinib, Con7


title: Lapatinib, Con7, Screening plate 3, Well J18 [S4881Nr8_J18]


title: Lapatinib, Con7, Screening plate 3, Well L18 [S4881Nr8_L18]


title: Lapatinib, Con8, Screening plate 3, Well J17 [S4881Nr8_J17]

value: Lapatinib, Con8


title: Isoproterenol, Con1, Screening plate 3, Well L16 [S4881Nr8_L16]

value: Isoproterenol, Con1


title: Lapatinib, Con8, Screening plate 3, Well L17 [S4881Nr8_L17]


title: Isoproterenol, Con1, Screening plate 3, Well K16 [S4881Nr8_K16]


title: Lapatinib, Con8, Screening plate 3, Well K17 [S4881Nr8_K17]


title: Isoproterenol, Con1, Screening plate 3, Well J16 [S4881Nr8_J16]


title: Isoproterenol, Con3, Screening plate 3, Well L14 [S4881Nr8_L14]

value: Isoproterenol, Con3


title: Isoproterenol, Con2, Screening plate 3, Well L15 [S4881Nr8_L15]

value: Isoproterenol, Con2


title: Isoproterenol, Con2, Screening plate 3, Well J15 [S4881Nr8_J15]


title: Isoproterenol, Con2, Screening plate 3, Well K15 [S4881Nr8_K15]


title: Isoproterenol, Con3, Screening plate 3, Well J14 [S4881Nr8_J14]


title: Isoproterenol, Con3, Screening plate 3, Well K14 [S4881Nr8_K14]


title: Isoproterenol, Con4, Screening plate 3, Well L13 [S4881Nr8_L13]

value: Isoproterenol, Con4


title: Isoproterenol, Con4, Screening plate 3, Well K13 [S4881Nr8_K13]


title: Isoproterenol, Con4, Screening plate 3, Well J13 [S4881Nr8_J13]


title: Isoproterenol, Con5, Screening plate 3, Well J12 [S4881Nr8_J12]

value: Isoproterenol, Con5


title: Isoproterenol, Con5, Screening plate 3, Well K12 [S4881Nr8_K12]


title: Isoproterenol, Con5, Screening plate 3, Well L12 [S4881Nr8_L12]


title: Isoproterenol, Con6, Screening plate 3, Well K11 [S4881Nr8_K11]

value: Isoproterenol, Con6


title: Isoproterenol, Con6, Screening plate 3, Well L11 [S4881Nr8_L11]


title: Isoproterenol, Con7, Screening plate 3, Well L10 [S4881Nr8_L10]

value: Isoproterenol, Con7


title: Isoproterenol, Con6, Screening plate 3, Well J11 [S4881Nr8_J11]


title: Isoproterenol, Con7, Screening plate 3, Well K10 [S4881Nr8_K10]


title: Isoproterenol, Con8, Screening plate 3, Well K9 [S4881Nr8_K9]

value: Isoproterenol, Con8


title: Isoproterenol, Con8, Screening plate 3, Well J9 [S4881Nr8_J9]


title: Idarubicin, Con1, Screening plate 3, Well L8 [S4881Nr8_L8]

value: Idarubicin, Con1


title: Idarubicin, Con1, Screening plate 3, Well J8 [S4881Nr8_J8]


title: Idarubicin, Con1, Screening plate 3, Well K8 [S4881Nr8_K8]


title: Idarubicin, Con2, Screening plate 3, Well L7 [S4881Nr8_L7]

value: Idarubicin, Con2


title: Idarubicin, Con2, Screening plate 3, Well K7 [S4881Nr8_K7]


title: Idarubicin, Con2, Screening plate 3, Well J7 [S4881Nr8_J7]


title: Idarubicin, Con3, Screening plate 3, Well J6 [S4881Nr8_J6]

value: Idarubicin, Con3


title: Idarubicin, Con3, Screening plate 3, Well K6 [S4881Nr8_K6]


title: Idarubicin, Con4, Screening plate 3, Well L5 [S4881Nr8_L5]

value: Idarubicin, Con4


title: Idarubicin, Con3, Screening plate 3, Well L6 [S4881Nr8_L6]

value: hiPSC-CM


title: Idarubicin, Con4, Screening plate 3, Well K5 [S4881Nr8_K5]

value: WT


title: Idarubicin, Con4, Screening plate 3, Well J5 [S4881Nr8_J5]


title: Idarubicin, Con5, Screening plate 3, Well J4 [S4881Nr8_J4]

value: Idarubicin, Con5


title: Idarubicin, Con5, Screening plate 3, Well L4 [S4881Nr8_L4]


title: Idarubicin, Con6, Screening plate 3, Well K3 [S4881Nr8_K3]

value: Idarubicin, Con6


title: Idarubicin, Con6, Screening plate 3, Well L3 [S4881Nr8_L3]


title: Idarubicin, Con7, Screening plate 3, Well K2 [S4881Nr8_K2]

value: Idarubicin, Con7


title: Idarubicin, Con5, Screening plate 3, Well K4 [S4881Nr8_K4]


title: Idarubicin, Con7, Screening plate 3, Well J2 [S4881Nr8_J2]


title: Idarubicin, Con8, Screening plate 3, Well L1 [S4881Nr8_L1]

value: Idarubicin, Con8


title: Idarubicin, Con8, Screening plate 3, Well K1 [S4881Nr8_K1]


title: Isoproterenol, Con8, Screening plate 3, Well L9 [S4881Nr8_L9]


title: Idarubicin, Con7, Screening plate 3, Well L2 [S4881Nr8_L2]


title: Isoproterenol, Con7, Screening plate 3, Well J10 [S4881Nr8_J10]


title: Doxorubicin, Con2, Screening plate 3, Well I23 [S4881Nr8_I23]

value: Doxorubicin, Con2


title: Doxorubicin, Con2, Screening plate 3, Well H23 [S4881Nr8_H23]


title: Doxorubicin, Con1, Screening plate 3, Well H24 [S4881Nr8_H24]

value: Doxorubicin, Con1


title: Doxorubicin, Con1, Screening plate 3, Well G24 [S4881Nr8_G24]


title: Doxorubicin, Con5, Screening plate 3, Well H20 [S4881Nr8_H20]

value: Doxorubicin, Con5


title: Idarubicin, Con6, Screening plate 3, Well J3 [S4881Nr8_J3]


title: Doxorubicin, Con3, Screening plate 3, Well H22 [S4881Nr8_H22]

value: Doxorubicin, Con3


title: Doxorubicin, Con6, Screening plate 3, Well I19 [S4881Nr8_I19]

value: Doxorubicin, Con6


title: Doxorubicin, Con7, Screening plate 3, Well I18 [S4881Nr8_I18]

value: Doxorubicin, Con7


title: Doxorubicin, Con3, Screening plate 3, Well G22 [S4881Nr8_G22]


title: Doxorubicin, Con4, Screening plate 3, Well I21 [S4881Nr8_I21]

value: Doxorubicin, Con4


title: Doxorubicin, Con7, Screening plate 3, Well H18 [S4881Nr8_H18]


title: Doxorubicin, Con1, Screening plate 3, Well I24 [S4881Nr8_I24]


title: Doxorubicin, Con4, Screening plate 3, Well G21 [S4881Nr8_G21]


title: Doxorubicin, Con4, Screening plate 3, Well H21 [S4881Nr8_H21]


title: Doxorubicin, Con8, Screening plate 3, Well G17 [S4881Nr8_G17]

value: Doxorubicin, Con8


title: Amiodarone, Con1, Screening plate 3, Well G16 [S4881Nr8_G16]

value: Amiodarone, Con1


title: Doxorubicin, Con5, Screening plate 3, Well I20 [S4881Nr8_I20]


title: Doxorubicin, Con2, Screening plate 3, Well G23 [S4881Nr8_G23]


title: Doxorubicin, Con6, Screening plate 3, Well H19 [S4881Nr8_H19]


title: Doxorubicin, Con5, Screening plate 3, Well G20 [S4881Nr8_G20]


title: Doxorubicin, Con6, Screening plate 3, Well G19 [S4881Nr8_G19]


title: Doxorubicin, Con3, Screening plate 3, Well I22 [S4881Nr8_I22]


title: Amiodarone, Con2, Screening plate 3, Well I15 [S4881Nr8_I15]

value: Amiodarone, Con2


title: Doxorubicin, Con7, Screening plate 3, Well G18 [S4881Nr8_G18]


title: Idarubicin, Con8, Screening plate 3, Well J1 [S4881Nr8_J1]


title: Amiodarone, Con2, Screening plate 3, Well G15 [S4881Nr8_G15]


title: Doxorubicin, Con8, Screening plate 3, Well I17 [S4881Nr8_I17]


title: Amiodarone, Con3, Screening plate 3, Well I14 [S4881Nr8_I14]

value: Amiodarone, Con3


title: Doxorubicin, Con8, Screening plate 3, Well H17 [S4881Nr8_H17]

value: hiPSC-CM


title: Amiodarone, Con3, Screening plate 3, Well H14 [S4881Nr8_H14]

value: WT


title: Amiodarone, Con1, Screening plate 3, Well H16 [S4881Nr8_H16]


title: Amiodarone, Con2, Screening plate 3, Well H15 [S4881Nr8_H15]


title: Amiodarone, Con4, Screening plate 3, Well I13 [S4881Nr8_I13]

value: Amiodarone, Con4


title: Amiodarone, Con1, Screening plate 3, Well I16 [S4881Nr8_I16]


title: Amiodarone, Con4, Screening plate 3, Well H13 [S4881Nr8_H13]


title: Amiodarone, Con5, Screening plate 3, Well I12 [S4881Nr8_I12]

value: Amiodarone, Con5


title: Amiodarone, Con5, Screening plate 3, Well G12 [S4881Nr8_G12]


title: Amiodarone, Con6, Screening plate 3, Well G11 [S4881Nr8_G11]

value: Amiodarone, Con6


title: Amiodarone, Con7, Screening plate 3, Well I10 [S4881Nr8_I10]

value: Amiodarone, Con7


title: Amiodarone, Con7, Screening plate 3, Well H10 [S4881Nr8_H10]


title: Amiodarone, Con6, Screening plate 3, Well H11 [S4881Nr8_H11]


title: Amiodarone, Con8, Screening plate 3, Well I9 [S4881Nr8_I9]

value: Amiodarone, Con8


title: Amiodarone, Con8, Screening plate 3, Well G9 [S4881Nr8_G9]


title: Amiodarone, Con7, Screening plate 3, Well G10 [S4881Nr8_G10]


title: Rosiglitazone, Con1, Screening plate 3, Well I8 [S4881Nr8_I8]

value: Rosiglitazone, Con1


title: Rosiglitazone, Con1, Screening plate 3, Well H8 [S4881Nr8_H8]


title: Rosiglitazone, Con1, Screening plate 3, Well G8 [S4881Nr8_G8]


title: Amiodarone, Con8, Screening plate 3, Well H9 [S4881Nr8_H9]


title: Rosiglitazone, Con4, Screening plate 3, Well I5 [S4881Nr8_I5]

value: Rosiglitazone, Con4


title: Rosiglitazone, Con4, Screening plate 3, Well H5 [S4881Nr8_H5]


title: Rosiglitazone, Con2, Screening plate 3, Well I7 [S4881Nr8_I7]

value: Rosiglitazone, Con2


title: Rosiglitazone, Con4, Screening plate 3, Well G5 [S4881Nr8_G5]


title: Rosiglitazone, Con5, Screening plate 3, Well H4 [S4881Nr8_H4]

value: Rosiglitazone, Con5


title: Rosiglitazone, Con3, Screening plate 3, Well I6 [S4881Nr8_I6]

value: Rosiglitazone, Con3


title: Amiodarone, Con4, Screening plate 3, Well G13 [S4881Nr8_G13]


title: Rosiglitazone, Con6, Screening plate 3, Well I3 [S4881Nr8_I3]

value: Rosiglitazone, Con6


title: Rosiglitazone, Con2, Screening plate 3, Well G7 [S4881Nr8_G7]


title: Rosiglitazone, Con3, Screening plate 3, Well G6 [S4881Nr8_G6]


title: Amiodarone, Con3, Screening plate 3, Well G14 [S4881Nr8_G14]


title: Rosiglitazone, Con5, Screening plate 3, Well I4 [S4881Nr8_I4]


title: Amiodarone, Con6, Screening plate 3, Well I11 [S4881Nr8_I11]


title: Amiodarone, Con5, Screening plate 3, Well H12 [S4881Nr8_H12]


title: Rosiglitazone, Con5, Screening plate 3, Well G4 [S4881Nr8_G4]


title: Rosiglitazone, Con7, Screening plate 3, Well H2 [S4881Nr8_H2]

value: Rosiglitazone, Con7


title: Rosiglitazone, Con7, Screening plate 3, Well G2 [S4881Nr8_G2]


title: Rosiglitazone, Con2, Screening plate 3, Well H7 [S4881Nr8_H7]


title: Rosiglitazone, Con6, Screening plate 3, Well H3 [S4881Nr8_H3]


title: Rosiglitazone, Con3, Screening plate 3, Well H6 [S4881Nr8_H6]


title: Rosiglitazone, Con6, Screening plate 3, Well G3 [S4881Nr8_G3]


title: Rosiglitazone, Con8, Screening plate 3, Well H1 [S4881Nr8_H1]

value: Rosiglitazone, Con8


title: Rosiglitazone, Con8, Screening plate 3, Well I1 [S4881Nr8_I1]


title: Rosiglitazone, Con7, Screening plate 3, Well I2 [S4881Nr8_I2]


title: Rofecoxib, Con1, Screening plate 3, Well E24 [S4881Nr8_E24]

value: Rofecoxib, Con1


title: Rosiglitazone, Con8, Screening plate 3, Well G1 [S4881Nr8_G1]


title: Rofecoxib, Con2, Screening plate 3, Well F23 [S4881Nr8_F23]

value: Rofecoxib, Con2


title: Rofecoxib, Con1, Screening plate 3, Well D24 [S4881Nr8_D24]

value: hiPSC-CM


title: Rofecoxib, Con3, Screening plate 3, Well F22 [S4881Nr8_F22]

value: WT

value: Rofecoxib, Con3


title: Rofecoxib, Con4, Screening plate 3, Well E21 [S4881Nr8_E21]

value: Rofecoxib, Con4


title: Rofecoxib, Con3, Screening plate 3, Well E22 [S4881Nr8_E22]


title: Rofecoxib, Con4, Screening plate 3, Well D21 [S4881Nr8_D21]


title: Rofecoxib, Con3, Screening plate 3, Well D22 [S4881Nr8_D22]


title: Rofecoxib, Con5, Screening plate 3, Well E20 [S4881Nr8_E20]

value: Rofecoxib, Con5


title: Rofecoxib, Con5, Screening plate 3, Well D20 [S4881Nr8_D20]


title: Rofecoxib, Con6, Screening plate 3, Well F19 [S4881Nr8_F19]

value: Rofecoxib, Con6


title: Rofecoxib, Con5, Screening plate 3, Well F20 [S4881Nr8_F20]


title: Rofecoxib, Con4, Screening plate 3, Well F21 [S4881Nr8_F21]


title: Rofecoxib, Con2, Screening plate 3, Well E23 [S4881Nr8_E23]


title: Rofecoxib, Con2, Screening plate 3, Well D23 [S4881Nr8_D23]


title: Rofecoxib, Con6, Screening plate 3, Well D19 [S4881Nr8_D19]


title: Rofecoxib, Con7, Screening plate 3, Well F18 [S4881Nr8_F18]

value: Rofecoxib, Con7


title: Rofecoxib, Con6, Screening plate 3, Well E19 [S4881Nr8_E19]


title: Rofecoxib, Con7, Screening plate 3, Well D18 [S4881Nr8_D18]


title: Mitoxantrone, Con1, Screening plate 3, Well F16 [S4881Nr8_F16]

value: Mitoxantrone, Con1


title: Rofecoxib, Con8, Screening plate 3, Well E17 [S4881Nr8_E17]

value: Rofecoxib, Con8


title: Rofecoxib, Con1, Screening plate 3, Well F24 [S4881Nr8_F24]


title: Mitoxantrone, Con1, Screening plate 3, Well E16 [S4881Nr8_E16]


title: Rofecoxib, Con8, Screening plate 3, Well D17 [S4881Nr8_D17]


title: Mitoxantrone, Con2, Screening plate 3, Well F15 [S4881Nr8_F15]

value: Mitoxantrone, Con2


title: Mitoxantrone, Con2, Screening plate 3, Well E15 [S4881Nr8_E15]


title: Mitoxantrone, Con2, Screening plate 3, Well D15 [S4881Nr8_D15]


title: Mitoxantrone, Con3, Screening plate 3, Well F14 [S4881Nr8_F14]

value: Mitoxantrone, Con3


title: Mitoxantrone, Con3, Screening plate 3, Well D14 [S4881Nr8_D14]


title: Mitoxantrone, Con3, Screening plate 3, Well E14 [S4881Nr8_E14]


title: Mitoxantrone, Con4, Screening plate 3, Well F13 [S4881Nr8_F13]

value: Mitoxantrone, Con4


title: Mitoxantrone, Con4, Screening plate 3, Well E13 [S4881Nr8_E13]


title: Mitoxantrone, Con5, Screening plate 3, Well F12 [S4881Nr8_F12]

value: Mitoxantrone, Con5


title: Mitoxantrone, Con4, Screening plate 3, Well D13 [S4881Nr8_D13]


title: Mitoxantrone, Con5, Screening plate 3, Well D12 [S4881Nr8_D12]


title: Mitoxantrone, Con5, Screening plate 3, Well E12 [S4881Nr8_E12]


title: Mitoxantrone, Con6, Screening plate 3, Well E11 [S4881Nr8_E11]

value: Mitoxantrone, Con6


title: Mitoxantrone, Con7, Screening plate 3, Well F10 [S4881Nr8_F10]

value: Mitoxantrone, Con7


title: Rofecoxib, Con7, Screening plate 3, Well E18 [S4881Nr8_E18]


title: Mitoxantrone, Con6, Screening plate 3, Well F11 [S4881Nr8_F11]


title: Mitoxantrone, Con7, Screening plate 3, Well E10 [S4881Nr8_E10]


title: Mitoxantrone, Con8, Screening plate 3, Well D9 [S4881Nr8_D9]

value: Mitoxantrone, Con8


title: Mitoxantrone, Con8, Screening plate 3, Well F9 [S4881Nr8_F9]


title: Mitoxantrone, Con7, Screening plate 3, Well D10 [S4881Nr8_D10]


title: Mitoxantrone, Con1, Screening plate 3, Well D16 [S4881Nr8_D16]


title: Rofecoxib, Con8, Screening plate 3, Well F17 [S4881Nr8_F17]


title: Mitomycin_C, Con1, Screening plate 3, Well E8 [S4881Nr8_E8]

value: Mitomycin_C, Con1


title: Mitoxantrone, Con8, Screening plate 3, Well E9 [S4881Nr8_E9]

value: hiPSC-CM


title: Mitomycin_C, Con2, Screening plate 3, Well F7 [S4881Nr8_F7]

value: WT

value: Mitomycin_C, Con2


title: Mitomycin_C, Con3, Screening plate 3, Well F6 [S4881Nr8_F6]

value: Mitomycin_C, Con3


title: Mitomycin_C, Con2, Screening plate 3, Well E7 [S4881Nr8_E7]


title: Mitomycin_C, Con1, Screening plate 3, Well D8 [S4881Nr8_D8]


title: Mitomycin_C, Con3, Screening plate 3, Well D6 [S4881Nr8_D6]


title: Mitomycin_C, Con4, Screening plate 3, Well F5 [S4881Nr8_F5]

value: Mitomycin_C, Con4


title: Mitomycin_C, Con4, Screening plate 3, Well E5 [S4881Nr8_E5]


title: Mitomycin_C, Con4, Screening plate 3, Well D5 [S4881Nr8_D5]


title: Mitoxantrone, Con6, Screening plate 3, Well D11 [S4881Nr8_D11]


title: Mitomycin_C, Con5, Screening plate 3, Well F4 [S4881Nr8_F4]

value: Mitomycin_C, Con5


title: Mitomycin_C, Con5, Screening plate 3, Well E4 [S4881Nr8_E4]


title: Mitomycin_C, Con6, Screening plate 3, Well F3 [S4881Nr8_F3]

value: Mitomycin_C, Con6


title: Mitomycin_C, Con5, Screening plate 3, Well D4 [S4881Nr8_D4]


title: Mitomycin_C, Con6, Screening plate 3, Well D3 [S4881Nr8_D3]


title: Mitomycin_C, Con1, Screening plate 3, Well F8 [S4881Nr8_F8]


title: Mitomycin_C, Con7, Screening plate 3, Well E2 [S4881Nr8_E2]

value: Mitomycin_C, Con7


title: Mitomycin_C, Con7, Screening plate 3, Well F2 [S4881Nr8_F2]


title: Mitomycin_C, Con7, Screening plate 3, Well D2 [S4881Nr8_D2]


title: Mitomycin_C, Con6, Screening plate 3, Well E3 [S4881Nr8_E3]


title: Mitomycin_C, Con8, Screening plate 3, Well E1 [S4881Nr8_E1]

value: Mitomycin_C, Con8


title: DMSO, Con0, Screening plate 3, Well P9 [S4881Nr8_P9]

value: DMSO, Con0


title: DMSO, Con0, Screening plate 3, Well P8 [S4881Nr8_P8]


title: DMSO, Con0, Screening plate 3, Well P7 [S4881Nr8_P7]


title: Mitomycin_C, Con2, Screening plate 3, Well D7 [S4881Nr8_D7]


title: DMSO, Con0, Screening plate 3, Well P5 [S4881Nr8_P5]


title: DMSO, Con0, Screening plate 3, Well P6 [S4881Nr8_P6]


title: Mitomycin_C, Con8, Screening plate 3, Well D1 [S4881Nr8_D1]


title: DMSO, Con0, Screening plate 3, Well P4 [S4881Nr8_P4]


title: Mitomycin_C, Con3, Screening plate 3, Well E6 [S4881Nr8_E6]


title: DMSO, Con0, Screening plate 3, Well P3 [S4881Nr8_P3]


title: DMSO, Con0, Screening plate 3, Well P22 [S4881Nr8_P22]


title: DMSO, Con0, Screening plate 3, Well P21 [S4881Nr8_P21]


title: DMSO, Con0, Screening plate 3, Well P23 [S4881Nr8_P23]


title: DMSO, Con0, Screening plate 3, Well P20 [S4881Nr8_P20]


title: DMSO, Con0, Screening plate 3, Well P2 [S4881Nr8_P2]


title: DMSO, Con0, Screening plate 3, Well P19 [S4881Nr8_P19]


title: DMSO, Con0, Screening plate 3, Well P17 [S4881Nr8_P17]


title: DMSO, Con0, Screening plate 3, Well P18 [S4881Nr8_P18]


title: DMSO, Con0, Screening plate 3, Well P15 [S4881Nr8_P15]


title: DMSO, Con0, Screening plate 3, Well P14 [S4881Nr8_P14]


title: Mitomycin_C, Con8, Screening plate 3, Well F1 [S4881Nr8_F1]


title: DMSO, Con0, Screening plate 3, Well P13 [S4881Nr8_P13]


title: DMSO, Con0, Screening plate 3, Well P11 [S4881Nr8_P11]


title: DMSO, Con0, Screening plate 3, Well P12 [S4881Nr8_P12]


title: Imatinib, Con1, Screening plate 3, Well C24 [S4881Nr8_C24]

value: Imatinib, Con1


title: DMSO, Con0, Screening plate 3, Well P10 [S4881Nr8_P10]


title: Imatinib, Con2, Screening plate 3, Well C23 [S4881Nr8_C23]

value: Imatinib, Con2


title: Imatinib, Con1, Screening plate 3, Well B24 [S4881Nr8_B24]


title: Imatinib, Con1, Screening plate 3, Well A24 [S4881Nr8_A24]


title: Imatinib, Con2, Screening plate 3, Well B23 [S4881Nr8_B23]


title: Imatinib, Con3, Screening plate 3, Well A22 [S4881Nr8_A22]

value: Imatinib, Con3


title: Imatinib, Con3, Screening plate 3, Well C22 [S4881Nr8_C22]


title: Imatinib, Con3, Screening plate 3, Well B22 [S4881Nr8_B22]


title: Imatinib, Con5, Screening plate 3, Well C20 [S4881Nr8_C20]

value: Imatinib, Con5


title: Imatinib, Con4, Screening plate 3, Well C21 [S4881Nr8_C21]

value: Imatinib, Con4


title: Imatinib, Con2, Screening plate 3, Well A23 [S4881Nr8_A23]


title: Imatinib, Con4, Screening plate 3, Well A21 [S4881Nr8_A21]


title: Imatinib, Con5, Screening plate 3, Well B20 [S4881Nr8_B20]


title: Imatinib, Con6, Screening plate 3, Well C19 [S4881Nr8_C19]

value: Imatinib, Con6


title: Imatinib, Con6, Screening plate 3, Well A19 [S4881Nr8_A19]


title: Imatinib, Con6, Screening plate 3, Well B19 [S4881Nr8_B19]


title: Imatinib, Con5, Screening plate 3, Well A20 [S4881Nr8_A20]


title: Imatinib, Con7, Screening plate 3, Well C18 [S4881Nr8_C18]

value: Imatinib, Con7


title: DMSO, Con0, Screening plate 3, Well P16 [S4881Nr8_P16]

value: hiPSC-CM


title: Imatinib, Con7, Screening plate 3, Well B18 [S4881Nr8_B18]

value: WT


title: Imatinib, Con8, Screening plate 3, Well B17 [S4881Nr8_B17]

value: Imatinib, Con8


title: Imatinib, Con8, Screening plate 3, Well C17 [S4881Nr8_C17]


title: Imatinib, Con7, Screening plate 3, Well A18 [S4881Nr8_A18]


title: Imatinib, Con8, Screening plate 3, Well A17 [S4881Nr8_A17]


title: 5_Fluorouracil, Con1, Screening plate 3, Well C16 [S4881Nr8_C16]

value: 5_Fluorouracil, Con1


title: 5_Fluorouracil, Con1, Screening plate 3, Well B16 [S4881Nr8_B16]


title: 5_Fluorouracil, Con2, Screening plate 3, Well C15 [S4881Nr8_C15]

value: 5_Fluorouracil, Con2


title: 5_Fluorouracil, Con2, Screening plate 3, Well B15 [S4881Nr8_B15]


title: Imatinib, Con4, Screening plate 3, Well B21 [S4881Nr8_B21]


title: 5_Fluorouracil, Con1, Screening plate 3, Well A16 [S4881Nr8_A16]


title: 5_Fluorouracil, Con2, Screening plate 3, Well A15 [S4881Nr8_A15]


title: 5_Fluorouracil, Con3, Screening plate 3, Well B14 [S4881Nr8_B14]

value: 5_Fluorouracil, Con3


title: 5_Fluorouracil, Con3, Screening plate 3, Well C14 [S4881Nr8_C14]


title: 5_Fluorouracil, Con3, Screening plate 3, Well A14 [S4881Nr8_A14]


title: 5_Fluorouracil, Con4, Screening plate 3, Well A13 [S4881Nr8_A13]

value: 5_Fluorouracil, Con4


title: 5_Fluorouracil, Con5, Screening plate 3, Well C12 [S4881Nr8_C12]

value: 5_Fluorouracil, Con5


title: 5_Fluorouracil, Con6, Screening plate 3, Well C11 [S4881Nr8_C11]

value: 5_Fluorouracil, Con6


title: 5_Fluorouracil, Con4, Screening plate 3, Well B13 [S4881Nr8_B13]


title: 5_Fluorouracil, Con5, Screening plate 3, Well B12 [S4881Nr8_B12]


title: 5_Fluorouracil, Con4, Screening plate 3, Well C13 [S4881Nr8_C13]


title: 5_Fluorouracil, Con6, Screening plate 3, Well B11 [S4881Nr8_B11]


title: 5_Fluorouracil, Con7, Screening plate 3, Well B10 [S4881Nr8_B10]

value: 5_Fluorouracil, Con7


title: 5_Fluorouracil, Con7, Screening plate 3, Well C10 [S4881Nr8_C10]


title: 5_Fluorouracil, Con7, Screening plate 3, Well A10 [S4881Nr8_A10]


title: 5_Fluorouracil, Con5, Screening plate 3, Well A12 [S4881Nr8_A12]


title: 5_Fluorouracil, Con8, Screening plate 3, Well A9 [S4881Nr8_A9]

value: 5_Fluorouracil, Con8


title: 5_Fluorouracil, Con8, Screening plate 3, Well B9 [S4881Nr8_B9]


title: 5_Fluorouracil, Con6, Screening plate 3, Well A11 [S4881Nr8_A11]


title: Dasatinib, Con2, Screening plate 3, Well C7 [S4881Nr8_C7]

value: Dasatinib, Con2


title: Dasatinib, Con2, Screening plate 3, Well B7 [S4881Nr8_B7]


title: Dasatinib, Con1, Screening plate 3, Well A8 [S4881Nr8_A8]

value: Dasatinib, Con1


title: Dasatinib, Con1, Screening plate 3, Well C8 [S4881Nr8_C8]


title: Dasatinib, Con2, Screening plate 3, Well A7 [S4881Nr8_A7]


title: Dasatinib, Con3, Screening plate 3, Well C6 [S4881Nr8_C6]

value: Dasatinib, Con3


title: Dasatinib, Con3, Screening plate 3, Well B6 [S4881Nr8_B6]


title: Dasatinib, Con4, Screening plate 3, Well C5 [S4881Nr8_C5]

value: Dasatinib, Con4


title: Dasatinib, Con4, Screening plate 3, Well B5 [S4881Nr8_B5]


title: Dasatinib, Con3, Screening plate 3, Well A6 [S4881Nr8_A6]


title: Dasatinib, Con5, Screening plate 3, Well B4 [S4881Nr8_B4]

value: Dasatinib, Con5


title: Dasatinib, Con5, Screening plate 3, Well A4 [S4881Nr8_A4]


title: Dasatinib, Con7, Screening plate 3, Well C2 [S4881Nr8_C2]

value: Dasatinib, Con7


title: 5_Fluorouracil, Con8, Screening plate 3, Well C9 [S4881Nr8_C9]

value: hiPSC-CM


title: Dasatinib, Con4, Screening plate 3, Well A5 [S4881Nr8_A5]

value: WT


title: Dasatinib, Con8, Screening plate 3, Well C1 [S4881Nr8_C1]

value: Dasatinib, Con8


title: NoTreatment, NoTreatment, Screening plate 2, Well P24 [S4881Nr7_P24]

value: NoTreatment, NoTreatment


title: NoTreatment, NoTreatment, Screening plate 2, Well P1 [S4881Nr7_P1]


title: Dasatinib, Con6, Screening plate 3, Well C3 [S4881Nr8_C3]

value: Dasatinib, Con6


title: Dasatinib, Con6, Screening plate 3, Well A3 [S4881Nr8_A3]


title: Dasatinib, Con1, Screening plate 3, Well B8 [S4881Nr8_B8]


title: Sunitinib, Con1, Screening plate 2, Well O24 [S4881Nr7_O24]

value: Sunitinib, Con1


title: Sunitinib, Con1, Screening plate 2, Well M24 [S4881Nr7_M24]


title: Dasatinib, Con5, Screening plate 3, Well C4 [S4881Nr8_C4]


title: Dasatinib, Con8, Screening plate 3, Well A1 [S4881Nr8_A1]


title: Dasatinib, Con7, Screening plate 3, Well A2 [S4881Nr8_A2]


title: Sunitinib, Con2, Screening plate 2, Well O23 [S4881Nr7_O23]

value: Sunitinib, Con2


title: Sunitinib, Con2, Screening plate 2, Well M23 [S4881Nr7_M23]


title: Sunitinib, Con2, Screening plate 2, Well N23 [S4881Nr7_N23]


title: Sunitinib, Con3, Screening plate 2, Well N22 [S4881Nr7_N22]

value: Sunitinib, Con3


title: Sunitinib, Con3, Screening plate 2, Well M22 [S4881Nr7_M22]


title: Dasatinib, Con7, Screening plate 3, Well B2 [S4881Nr8_B2]


title: Sunitinib, Con4, Screening plate 2, Well O21 [S4881Nr7_O21]

value: Sunitinib, Con4


title: Sunitinib, Con4, Screening plate 2, Well M21 [S4881Nr7_M21]


title: Sunitinib, Con5, Screening plate 2, Well O20 [S4881Nr7_O20]

value: Sunitinib, Con5


title: Dasatinib, Con6, Screening plate 3, Well B3 [S4881Nr8_B3]


title: Sunitinib, Con5, Screening plate 2, Well N20 [S4881Nr7_N20]


title: Dasatinib, Con8, Screening plate 3, Well B1 [S4881Nr8_B1]


title: Sunitinib, Con6, Screening plate 2, Well N19 [S4881Nr7_N19]

value: Sunitinib, Con6


title: Sunitinib, Con1, Screening plate 2, Well N24 [S4881Nr7_N24]


title: Sunitinib, Con4, Screening plate 2, Well N21 [S4881Nr7_N21]


title: Sunitinib, Con7, Screening plate 2, Well O18 [S4881Nr7_O18]

value: Sunitinib, Con7


title: Sunitinib, Con7, Screening plate 2, Well M18 [S4881Nr7_M18]


title: Sunitinib, Con3, Screening plate 2, Well O22 [S4881Nr7_O22]


title: Sunitinib, Con5, Screening plate 2, Well M20 [S4881Nr7_M20]


title: Tolbutamide, Con1, Screening plate 2, Well O16 [S4881Nr7_O16]

value: Tolbutamide, Con1


title: Sunitinib, Con6, Screening plate 2, Well O19 [S4881Nr7_O19]


title: Tolbutamide, Con2, Screening plate 2, Well N15 [S4881Nr7_N15]

value: Tolbutamide, Con2


title: Tolbutamide, Con2, Screening plate 2, Well M15 [S4881Nr7_M15]


title: Tolbutamide, Con3, Screening plate 2, Well O14 [S4881Nr7_O14]

value: Tolbutamide, Con3


title: Sunitinib, Con6, Screening plate 2, Well M19 [S4881Nr7_M19]


title: Tolbutamide, Con4, Screening plate 2, Well N13 [S4881Nr7_N13]

value: Tolbutamide, Con4


title: Sunitinib, Con7, Screening plate 2, Well N18 [S4881Nr7_N18]


title: Tolbutamide, Con3, Screening plate 2, Well M14 [S4881Nr7_M14]


title: Tolbutamide, Con4, Screening plate 2, Well O13 [S4881Nr7_O13]


title: Tolbutamide, Con5, Screening plate 2, Well N12 [S4881Nr7_N12]

value: Tolbutamide, Con5


title: Tolbutamide, Con4, Screening plate 2, Well M13 [S4881Nr7_M13]

value: hiPSC-CM


title: Sunitinib, Con8, Screening plate 2, Well M17 [S4881Nr7_M17]

value: WT

value: Sunitinib, Con8


title: Sunitinib, Con8, Screening plate 2, Well O17 [S4881Nr7_O17]


title: Tolbutamide, Con5, Screening plate 2, Well M12 [S4881Nr7_M12]


title: Sunitinib, Con8, Screening plate 2, Well N17 [S4881Nr7_N17]


title: Tolbutamide, Con6, Screening plate 2, Well N11 [S4881Nr7_N11]

value: Tolbutamide, Con6


title: Tolbutamide, Con7, Screening plate 2, Well N10 [S4881Nr7_N10]

value: Tolbutamide, Con7


title: Tolbutamide, Con1, Screening plate 2, Well N16 [S4881Nr7_N16]


title: Tolbutamide, Con1, Screening plate 2, Well M16 [S4881Nr7_M16]


title: Tolbutamide, Con7, Screening plate 2, Well M10 [S4881Nr7_M10]


title: Tolbutamide, Con2, Screening plate 2, Well O15 [S4881Nr7_O15]


title: Tolbutamide, Con3, Screening plate 2, Well N14 [S4881Nr7_N14]


title: Tolbutamide, Con5, Screening plate 2, Well O12 [S4881Nr7_O12]


title: Tolbutamide, Con6, Screening plate 2, Well O11 [S4881Nr7_O11]


title: Amphotericin_B, Con1, Screening plate 2, Well O8 [S4881Nr7_O8]

value: Amphotericin_B, Con1


title: Tolbutamide, Con6, Screening plate 2, Well M11 [S4881Nr7_M11]


title: Tolbutamide, Con8, Screening plate 2, Well O9 [S4881Nr7_O9]

value: Tolbutamide, Con8


title: Tolbutamide, Con8, Screening plate 2, Well N9 [S4881Nr7_N9]


title: Tolbutamide, Con7, Screening plate 2, Well O10 [S4881Nr7_O10]


title: Amphotericin_B, Con4, Screening plate 2, Well O5 [S4881Nr7_O5]

value: Amphotericin_B, Con4


title: Tolbutamide, Con8, Screening plate 2, Well M9 [S4881Nr7_M9]


title: Amphotericin_B, Con3, Screening plate 2, Well O6 [S4881Nr7_O6]

value: Amphotericin_B, Con3


title: Amphotericin_B, Con3, Screening plate 2, Well N6 [S4881Nr7_N6]


title: Amphotericin_B, Con5, Screening plate 2, Well O4 [S4881Nr7_O4]

value: Amphotericin_B, Con5


title: Amphotericin_B, Con4, Screening plate 2, Well N5 [S4881Nr7_N5]


title: Amphotericin_B, Con1, Screening plate 2, Well M8 [S4881Nr7_M8]


title: Amphotericin_B, Con1, Screening plate 2, Well N8 [S4881Nr7_N8]


title: Amphotericin_B, Con2, Screening plate 2, Well N7 [S4881Nr7_N7]

value: Amphotericin_B, Con2


title: Amphotericin_B, Con3, Screening plate 2, Well M6 [S4881Nr7_M6]


title: Amphotericin_B, Con2, Screening plate 2, Well O7 [S4881Nr7_O7]


title: Amphotericin_B, Con5, Screening plate 2, Well M4 [S4881Nr7_M4]


title: Amphotericin_B, Con6, Screening plate 2, Well N3 [S4881Nr7_N3]

value: Amphotericin_B, Con6


title: Amphotericin_B, Con5, Screening plate 2, Well N4 [S4881Nr7_N4]


title: Amphotericin_B, Con2, Screening plate 2, Well M7 [S4881Nr7_M7]


title: Amphotericin_B, Con6, Screening plate 2, Well O3 [S4881Nr7_O3]


title: Amphotericin_B, Con6, Screening plate 2, Well M3 [S4881Nr7_M3]


title: Amphotericin_B, Con7, Screening plate 2, Well O2 [S4881Nr7_O2]

value: Amphotericin_B, Con7


title: Bortezomib, Con1, Screening plate 2, Well L24 [S4881Nr7_L24]

value: Bortezomib, Con1


title: Amphotericin_B, Con7, Screening plate 2, Well M2 [S4881Nr7_M2]


title: Amphotericin_B, Con8, Screening plate 2, Well O1 [S4881Nr7_O1]

value: Amphotericin_B, Con8


title: Bortezomib, Con1, Screening plate 2, Well K24 [S4881Nr7_K24]


title: Amphotericin_B, Con8, Screening plate 2, Well M1 [S4881Nr7_M1]


title: Bortezomib, Con1, Screening plate 2, Well J24 [S4881Nr7_J24]


title: Bortezomib, Con2, Screening plate 2, Well L23 [S4881Nr7_L23]

value: Bortezomib, Con2


title: Bortezomib, Con2, Screening plate 2, Well K23 [S4881Nr7_K23]


title: Amphotericin_B, Con4, Screening plate 2, Well M5 [S4881Nr7_M5]


title: Bortezomib, Con3, Screening plate 2, Well L22 [S4881Nr7_L22]

value: Bortezomib, Con3


title: Bortezomib, Con3, Screening plate 2, Well K22 [S4881Nr7_K22]

value: hiPSC-CM


title: Bortezomib, Con3, Screening plate 2, Well J22 [S4881Nr7_J22]

value: WT


title: Bortezomib, Con5, Screening plate 2, Well K20 [S4881Nr7_K20]

value: Bortezomib, Con5


title: Amphotericin_B, Con7, Screening plate 2, Well N2 [S4881Nr7_N2]


title: Bortezomib, Con5, Screening plate 2, Well L20 [S4881Nr7_L20]


title: Bortezomib, Con4, Screening plate 2, Well J21 [S4881Nr7_J21]

value: Bortezomib, Con4


title: Bortezomib, Con4, Screening plate 2, Well K21 [S4881Nr7_K21]


title: Bortezomib, Con6, Screening plate 2, Well L19 [S4881Nr7_L19]

value: Bortezomib, Con6


title: Bortezomib, Con6, Screening plate 2, Well K19 [S4881Nr7_K19]


title: Bortezomib, Con7, Screening plate 2, Well L18 [S4881Nr7_L18]

value: Bortezomib, Con7


title: Bortezomib, Con6, Screening plate 2, Well J19 [S4881Nr7_J19]


title: Bortezomib, Con8, Screening plate 2, Well K17 [S4881Nr7_K17]

value: Bortezomib, Con8


title: Bortezomib, Con7, Screening plate 2, Well K18 [S4881Nr7_K18]


title: Amphotericin_B, Con8, Screening plate 2, Well N1 [S4881Nr7_N1]


title: Bortezomib, Con8, Screening plate 2, Well J17 [S4881Nr7_J17]


title: 3_Azido_3_Deoxythymidine, Con1, Screening plate 2, Well K16 [S4881Nr7_K16]

value: 3_Azido_3_Deoxythymidine, Con1


title: 3_Azido_3_Deoxythymidine, Con1, Screening plate 2, Well J16 [S4881Nr7_J16]


title: 3_Azido_3_Deoxythymidine, Con2, Screening plate 2, Well K15 [S4881Nr7_K15]

value: 3_Azido_3_Deoxythymidine, Con2


title: 3_Azido_3_Deoxythymidine, Con2, Screening plate 2, Well L15 [S4881Nr7_L15]


title: Bortezomib, Con8, Screening plate 2, Well L17 [S4881Nr7_L17]


title: 3_Azido_3_Deoxythymidine, Con3, Screening plate 2, Well L14 [S4881Nr7_L14]

value: 3_Azido_3_Deoxythymidine, Con3


title: Bortezomib, Con4, Screening plate 2, Well L21 [S4881Nr7_L21]


title: 3_Azido_3_Deoxythymidine, Con2, Screening plate 2, Well J15 [S4881Nr7_J15]


title: 3_Azido_3_Deoxythymidine, Con3, Screening plate 2, Well K14 [S4881Nr7_K14]


title: 3_Azido_3_Deoxythymidine, Con3, Screening plate 2, Well J14 [S4881Nr7_J14]


title: Bortezomib, Con5, Screening plate 2, Well J20 [S4881Nr7_J20]


title: 3_Azido_3_Deoxythymidine, Con4, Screening plate 2, Well J13 [S4881Nr7_J13]

value: 3_Azido_3_Deoxythymidine, Con4


title: 3_Azido_3_Deoxythymidine, Con5, Screening plate 2, Well J12 [S4881Nr7_J12]

value: 3_Azido_3_Deoxythymidine, Con5


title: 3_Azido_3_Deoxythymidine, Con5, Screening plate 2, Well L12 [S4881Nr7_L12]


title: Bortezomib, Con7, Screening plate 2, Well J18 [S4881Nr7_J18]


title: 3_Azido_3_Deoxythymidine, Con6, Screening plate 2, Well K11 [S4881Nr7_K11]

value: 3_Azido_3_Deoxythymidine, Con6


title: 3_Azido_3_Deoxythymidine, Con6, Screening plate 2, Well J11 [S4881Nr7_J11]


title: 3_Azido_3_Deoxythymidine, Con7, Screening plate 2, Well L10 [S4881Nr7_L10]

value: 3_Azido_3_Deoxythymidine, Con7


title: 3_Azido_3_Deoxythymidine, Con7, Screening plate 2, Well K10 [S4881Nr7_K10]


title: 3_Azido_3_Deoxythymidine, Con5, Screening plate 2, Well K12 [S4881Nr7_K12]


title: 3_Azido_3_Deoxythymidine, Con8, Screening plate 2, Well L9 [S4881Nr7_L9]

value: 3_Azido_3_Deoxythymidine, Con8


title: 3_Azido_3_Deoxythymidine, Con7, Screening plate 2, Well J10 [S4881Nr7_J10]


title: 3_Azido_3_Deoxythymidine, Con8, Screening plate 2, Well K9 [S4881Nr7_K9]


title: 3_Azido_3_Deoxythymidine, Con8, Screening plate 2, Well J9 [S4881Nr7_J9]


title: Cyclophosphamide, Con1, Screening plate 2, Well L8 [S4881Nr7_L8]

value: Cyclophosphamide, Con1


title: Cyclophosphamide, Con1, Screening plate 2, Well J8 [S4881Nr7_J8]


title: Cyclophosphamide, Con2, Screening plate 2, Well J7 [S4881Nr7_J7]

value: Cyclophosphamide, Con2


title: 3_Azido_3_Deoxythymidine, Con1, Screening plate 2, Well L16 [S4881Nr7_L16]

value: hiPSC-CM


title: Cyclophosphamide, Con3, Screening plate 2, Well L6 [S4881Nr7_L6]

value: WT

value: Cyclophosphamide, Con3


title: 3_Azido_3_Deoxythymidine, Con4, Screening plate 2, Well L13 [S4881Nr7_L13]


title: Cyclophosphamide, Con2, Screening plate 2, Well K7 [S4881Nr7_K7]


title: Cyclophosphamide, Con2, Screening plate 2, Well L7 [S4881Nr7_L7]


title: 3_Azido_3_Deoxythymidine, Con4, Screening plate 2, Well K13 [S4881Nr7_K13]


title: Cyclophosphamide, Con3, Screening plate 2, Well J6 [S4881Nr7_J6]


title: Cyclophosphamide, Con3, Screening plate 2, Well K6 [S4881Nr7_K6]


title: Bortezomib, Con2, Screening plate 2, Well J23 [S4881Nr7_J23]

value: Bortezomib, Con2


title: Cyclophosphamide, Con4, Screening plate 2, Well J5 [S4881Nr7_J5]

value: Cyclophosphamide, Con4


title: Cyclophosphamide, Con4, Screening plate 2, Well K5 [S4881Nr7_K5]


title: Cyclophosphamide, Con5, Screening plate 2, Well L4 [S4881Nr7_L4]

value: Cyclophosphamide, Con5


title: 3_Azido_3_Deoxythymidine, Con6, Screening plate 2, Well L11 [S4881Nr7_L11]


title: Cyclophosphamide, Con4, Screening plate 2, Well L5 [S4881Nr7_L5]


title: Cyclophosphamide, Con6, Screening plate 2, Well L3 [S4881Nr7_L3]

value: Cyclophosphamide, Con6


title: Cyclophosphamide, Con6, Screening plate 2, Well J3 [S4881Nr7_J3]


title: Cyclophosphamide, Con6, Screening plate 2, Well K3 [S4881Nr7_K3]


title: Cyclophosphamide, Con7, Screening plate 2, Well J2 [S4881Nr7_J2]

value: Cyclophosphamide, Con7


title: Cyclophosphamide, Con7, Screening plate 2, Well L2 [S4881Nr7_L2]


title: Cyclophosphamide, Con1, Screening plate 2, Well K8 [S4881Nr7_K8]


title: Cyclophosphamide, Con7, Screening plate 2, Well K2 [S4881Nr7_K2]


title: Cyclophosphamide, Con8, Screening plate 2, Well J1 [S4881Nr7_J1]

value: Cyclophosphamide, Con8


title: Sotalol, Con1, Screening plate 2, Well I24 [S4881Nr7_I24]

value: Sotalol, Con1


title: Cyclophosphamide, Con8, Screening plate 2, Well L1 [S4881Nr7_L1]


title: Cyclophosphamide, Con8, Screening plate 2, Well K1 [S4881Nr7_K1]


title: Sotalol, Con1, Screening plate 2, Well H24 [S4881Nr7_H24]


title: Sotalol, Con2, Screening plate 2, Well I23 [S4881Nr7_I23]

value: Sotalol, Con2


title: Sotalol, Con2, Screening plate 2, Well H23 [S4881Nr7_H23]


title: Sotalol, Con2, Screening plate 2, Well G23 [S4881Nr7_G23]


title: Sotalol, Con3, Screening plate 2, Well H22 [S4881Nr7_H22]

value: Sotalol, Con3


title: Sotalol, Con4, Screening plate 2, Well I21 [S4881Nr7_I21]

value: Sotalol, Con4


title: Sotalol, Con3, Screening plate 2, Well G22 [S4881Nr7_G22]


title: Sotalol, Con4, Screening plate 2, Well H21 [S4881Nr7_H21]


title: Sotalol, Con3, Screening plate 2, Well I22 [S4881Nr7_I22]


title: Sotalol, Con5, Screening plate 2, Well I20 [S4881Nr7_I20]

value: Sotalol, Con5


title: Sotalol, Con5, Screening plate 2, Well G20 [S4881Nr7_G20]


title: Sotalol, Con5, Screening plate 2, Well H20 [S4881Nr7_H20]


title: Sotalol, Con4, Screening plate 2, Well G21 [S4881Nr7_G21]


title: Cyclophosphamide, Con5, Screening plate 2, Well J4 [S4881Nr7_J4]


title: Sotalol, Con6, Screening plate 2, Well G19 [S4881Nr7_G19]

value: Sotalol, Con6


title: Sotalol, Con6, Screening plate 2, Well I19 [S4881Nr7_I19]


title: Cyclophosphamide, Con5, Screening plate 2, Well K4 [S4881Nr7_K4]


title: Sotalol, Con7, Screening plate 2, Well I18 [S4881Nr7_I18]

value: Sotalol, Con7


title: Sotalol, Con6, Screening plate 2, Well H19 [S4881Nr7_H19]


title: Sotalol, Con7, Screening plate 2, Well H18 [S4881Nr7_H18]


title: Sotalol, Con7, Screening plate 2, Well G18 [S4881Nr7_G18]


title: Sotalol, Con8, Screening plate 2, Well I17 [S4881Nr7_I17]

value: Sotalol, Con8


title: Sotalol, Con1, Screening plate 2, Well G24 [S4881Nr7_G24]

value: hiPSC-CM


title: Propranolol, Con1, Screening plate 2, Well I16 [S4881Nr7_I16]

value: WT

value: Propranolol, Con1


title: Propranolol, Con1, Screening plate 2, Well G16 [S4881Nr7_G16]


title: Propranolol, Con1, Screening plate 2, Well H16 [S4881Nr7_H16]


title: Propranolol, Con2, Screening plate 2, Well I15 [S4881Nr7_I15]

value: Propranolol, Con2


title: Sotalol, Con8, Screening plate 2, Well G17 [S4881Nr7_G17]


title: Propranolol, Con3, Screening plate 2, Well H14 [S4881Nr7_H14]

value: Propranolol, Con3


title: Propranolol, Con4, Screening plate 2, Well H13 [S4881Nr7_H13]

value: Propranolol, Con4


title: Propranolol, Con5, Screening plate 2, Well I12 [S4881Nr7_I12]

value: Propranolol, Con5


title: Propranolol, Con5, Screening plate 2, Well H12 [S4881Nr7_H12]


title: Propranolol, Con4, Screening plate 2, Well G13 [S4881Nr7_G13]


title: Sotalol, Con8, Screening plate 2, Well H17 [S4881Nr7_H17]


title: Propranolol, Con3, Screening plate 2, Well I14 [S4881Nr7_I14]


title: Propranolol, Con5, Screening plate 2, Well G12 [S4881Nr7_G12]


title: Propranolol, Con4, Screening plate 2, Well I13 [S4881Nr7_I13]


title: Propranolol, Con6, Screening plate 2, Well H11 [S4881Nr7_H11]

value: Propranolol, Con6


title: Propranolol, Con7, Screening plate 2, Well I10 [S4881Nr7_I10]

value: Propranolol, Con7


title: Propranolol, Con2, Screening plate 2, Well H15 [S4881Nr7_H15]


title: Propranolol, Con6, Screening plate 2, Well G11 [S4881Nr7_G11]


title: Propranolol, Con6, Screening plate 2, Well I11 [S4881Nr7_I11]


title: Propranolol, Con8, Screening plate 2, Well I9 [S4881Nr7_I9]

value: Propranolol, Con8


title: Propranolol, Con7, Screening plate 2, Well H10 [S4881Nr7_H10]


title: Propranolol, Con7, Screening plate 2, Well G10 [S4881Nr7_G10]


title: Nifedipine, Con1, Screening plate 2, Well I8 [S4881Nr7_I8]

value: Nifedipine, Con1


title: Propranolol, Con8, Screening plate 2, Well H9 [S4881Nr7_H9]


title: Nifedipine, Con1, Screening plate 2, Well H8 [S4881Nr7_H8]


title: Propranolol, Con8, Screening plate 2, Well G9 [S4881Nr7_G9]


title: Propranolol, Con3, Screening plate 2, Well G14 [S4881Nr7_G14]