title: H3K36me3_heart_E16_EC_cell_459


title: DP-0574 untreated B

status: Public on Apr 30 2024

type: SRA

city: Santa Monica

first: Dave

last: Hoon

state: CA

address: 2200 Santa Monica Boulevard

department: Translational Molecular Medicine

country: USA

institute: Saint John's Cancer Institute

library_source: transcriptomic

data_processing:
Base calling and demultiplexing were processed using CASAVA version 1.8
Reads were mapped using the GENCODE release 19 reference using STAR version 2.4.2a
Read counts were generated using the quantMode GeneCounts option in STAR.

molecule: total RNA

organism: Homo sapiens

extract_protocol:
RNA was isolated using the ZR-Duet DNA/RNA MiniPrep kit (Zymo Research, Irvine CA.)
mRNA libraries were constructed using the Bioo Scientific NEXTflex Rapid Directional RNA-seq Library Prep Kit.

tag: cell type

value: melanoma cancer cell line (MBM)

tag: cell line

tag: treatment

value: untreated


title: H3K36me3_heart_E16_EC_cell_458

city: Beijing

first: Yaxi

last: Liu

address: 5 Yiheyuan Road

country: China

institute: Peking University

library_source: genomic

data_processing:
Basecalls performed using CASAVA version 1.8.2.
Reads were de-multiplexed to generate single cell profiles by custom scripts. For spliting single cell, we cut the first 21 bp of the read1 and the first 27 bp of the read2.
Reads were aligned to mouse genome mm10 by bowtie2 (v 2.3.1), with parameter of "--dovetail --very-sensitive-local --no-unal --no-mixed --no-discordant -X 2000".
Reads whose MAPQ >= 30 were determined as uniquely mapping reads. Duplication reads were removed by Picard.
Cells with less than 1,000 non-duplicated were excluded.
Bed files were generated from bam files using bedtools (v2.25.0) bamToBed.
Genome_build: mm10
Supplementary_files_format_and_content: The processed files were bed files. Each single cell bed file contain non-duplicated alignments as is in the bam file.  These files contain single cell genome-wide coverage files after  sorting and uniqing and removing duplicates. Since one cell only contains two copies of each genomic locus for assay, we usually use non-duplicated reads information to reflect peak information in one single cell (PMID: 31471188).

molecule: genomic DNA

organism: Mus musculus

source_name: E16.5 heart

extract_protocol:
Following CoBATCH protocol.
After PCR enrichment using 2X KAPA master mix, products were purified and selected by AMPure XP beads for 200-1000 bp.

treatment_protocol: Organs were digested with 0.06 Collagenase II at 37 °C. "Aged" animals are 17-19 months old.

tag: developmental stage

tag: tissue

value: heart

tag: strain

tag: tissue preparation

value: Fixed by methanol

tag: chip antibody

value: H3K36me3, Active motif, Cat. 61101


title: CD11brGFP-Stroke-24h-3

type: RNA

city: Québec

first: Hejer

last: Boutej

state: Québec

address: 2601, de la Canardière

department: NEUROBIOLOGY

country: Canada

institute: LAVAL University

hyb_protocol: Samples were hybridized with Affymetrix Mouse Gene 2.0 ST microarray. The cRNA hybridization cocktail was incubated overnight at 45°C while rotating in a hybridization oven. After 16 h of hybridization, the cocktail was removed and the arrays were washed and stained in an Affymetrix GeneChip fluidics station 450, according to the Affymetrix-recommended protocol.

scan_protocol: The arrays were scanned using the Affymetrix GCS 3000 7G and the Gene-Chip Command Console Software (AGCC) (Affymetrix, Santa Clara, CA) to produce the probe cell intensity data (CEL). The image data were analyzed by using the Affymetrix Expression Console Software to perform the quality control, the background subtraction and the normalization of probe set intensities with the method of Robust Multiarray Analysis (RMA).

data_processing: For the visualization of microarray results we used Affymetrix Transcriptome Analysis Console (TAC) Software. A mRNA was considered as variant if the fold change between the two compared samples was higher than 1.2 and the associated ANOVA p-value was lower than 0.05.

label: Biotin

source_name: CD11brGFP mice; n=6

label_protocol: Ribosomes-associated mRNA (100 ng per sample) was labeled using the Affymetrix GeneChip® WT cDNA Synthesis and Amplification Kit protocol as described by the manufacturer (Affymetrix).

growth_protocol: CD11brGFP transgenic mice were used at 2-3 months old.

extract_protocol: mRNA was extracted using the Translational Affinity Purification (TRAP) protocol. The purification of the mRNA from the beads was perfomed according to the Absolutely RNA Nanoprep Kit's instructions

treatment_protocol: CD11brGFP transgenic mice were subjected to tMCAO-24hrs. Each group contains 6 mice with only males. Three biological replicates were used for control and for tMCAO-24hrs.

tag: genotype

value: CD11brGFP transgenic

value: tMCAO-24 hrs

tag: fraction

value: Ribosomes-associated mRNAs


title: CD11brGFP-CTL-1

value: Sham operated animals


title: H3K36me3_heart_E16_EC_cell_464


title: Naive_SM_Th2_K27ac_R2

city: Berlin

first: Ahmed

middle: Nabil

last: Hegazy

address: Hindenburgdamm 30

department: Department of Gastroenterology, Infectious Diseases and Rheumatology

country: Germany

institute: Charité - University Medicine Berlin

data_processing:
# Bowtie v1.2.1.1 bowtie -t -m 1 -S -q -p 8 <Genome Location > <FASTQ File > <SAM File Output >
# SICER v1.1 ( modified script )
SICER_modified.sh <Input file folder > <Input file name > <Control file name > <Output
folder > t mm10 1 200 150 0.8
# SICER params: ["InputDir"] ["bed file"] ["control file"] ["OutputDir"] ["Species"] ["redundancy threshold"] ["window sizes (bp) - submit multiple window sizes in quote"] ["fragment size"] ["effective genome fraction"] ["number of background islands for evalue (def: 1000)"]
Assembly: mm10
Supplementary files format and content: bed files: for K4me3 histone modifications the params are W200-G200-FDR0.01; for all others the params are W200-G600-FDR0.01

source_name: Spleen and lymph nodes

growth_protocol: Adoptively transferred WT, Tbx21+/-, Tbx21-/- LCMV‑TCRtg CD4+ Thy1.1+ cells from LCMV-challenged mice were isolated and MACS-sorted on day 10 of infection. Cells were cultured for two rounds under neutral (5 ng/ml IL-2 (Peprotech), 10 µg/ml anti–IL-4 (11B11), 10 µg/ml anti–IL-12 (C17.8), and 10 µg/ml anti–IFN-g (AN18.17.24)) or Th2 conditions (30 ng/ml IL-4 (Sigma-Aldrich), 5 ng/ml IL-2 (Peprotech), 10 µg/ml anti–IL-12 (C17.8), and 10 µg/ml anti–IFN-g (AN18.17.24)). On day 4 of the second round of stimulations the cells were harvested and processed for Chip-Seq.

extract_protocol:
Cells were incubated for 10min at room temperature with 1% formaldehyde. Cross-linking was terminated by addition of glycine to a final concentration of 125mM. ChIP was performed using iDeal ChIP-seq Kit (Diagenode) according to the manufacturer’s instructions. Antibodies against H3K4me3 (ab8580, Abcam), H3K4me1 (ab8895, Abcam), H3K27ac (ab4729, Abcam), H3K27me3 (ab6002, Abcam) and H3K9me3 (ab8898, Abcam) were used.
10ng of chromatin-immunoprecipitated DNA was end-repaired and dA-tailed. Subsequently, adaptor was ligated to the dA-tailed DNA. DNA was cleaned up using AMpure XP beads after each step. Adaptor-ligated DNA was size selected with AMpure XP beads using different DNA to beads ratio to an average fragment size of 200bp. At last step, size-selected and adaptor-ligated DNA was enriched by PCR with different index primers and cleaned up using AMpure XP beads. Purified library DNA was quantified with Qubit 2.0 and fragment size was assessed using Bioanalyzer (Agilent high sensitivity chip).

value: Spleen and lymph nodes

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells

value: CD4 T cells

value: Wild type

value: Th2 conditions


title: Naive_SM_Th2_K27me3_R1

treatment_protocol: Cells were cultured for two rounds under neutral (5 ng/ml IL-2 (Peprotech), 10 µg/ml anti–IL-4 (11B11), 10 µg/ml anti–IL-12 (C17.8), and 10 µg/ml anti–IFN-g (AN18.17.24)) or Th2 conditions (30 ng/ml IL-4 (Sigma-Aldrich), 5 ng/ml IL-2 (Peprotech), 10 µg/ml anti–IL-12 (C17.8), and 10 µg/ml anti–IFN-g (AN18.17.24)).


title: CD11brGFP-CTL-3


title: CD11brGFP-Stroke-24h-2


title: CD11brGFP-CTL-2


title: H3K36me3_heart_E16_EC_cell_457


title: Naive_SM_Th2_K27ac_R1


title: HOE_APP_vs_APP_WT_R4

city: São Paulo

first: Eduardo

middle: Moraes

last: Reis

state: SP

address: Av. Prof. Lineu Prestes, 748

department: Biochemistry

country: Brazil

institute: University of São Paulo

description: Replicate 4 of 4: HOE treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant

hyb_protocol: Agilent Gene Expression Hybridization Kit were used and labeled targets were incubated to na Agilent SurePrint G3 Mouse GE 8x60K Microarray enclosed in Agilent Microarray Hybridization Chamber. After hybridization, slides were washed sequentially.

scan_protocol: Agilent Feature Extraction Software (v 9.5)

data_processing: Four biological replicates were assessed with dye swap. gProcessedSignal and rProcessedSignal values were used to calculate log2 BK_APP/APP_WT ratios and log2 HOE_APP/APP_WT. Only the probes with significantly greater expression (as determined via the 2-sided t-test) compared with the corresponding background level (flag ‘IsWellAboveBG’) in 3 of the 4 control sample replicates were defined as expressed and further analysed.

source_name: APPswe/PS1dE9 cells

label_protocol: 100 ng of total RNA were DNAse-treated and amplified and labeled using Agilent Low RNA Input Fluorescent Linear Amplification Kit following manufacturer's instructions.

growth_protocol: NPCs were isolated from embryo telencephalon (day 13) of APPswe/PSldE9 C57BL/6 mice. All animal experiments were performed according to protocols approved by the ethics committee (authorization number: 10/2013). Isolated telencephalons were mechanically and enzymatically dissociated. A concentration of 2×105 cells/ml was seeded in 2% B-27 (Life Technologies, Carlsbad, CA), Dulbecco's modified Eagle's medium (DMEM) with Ham's F-12, antibiotics (100 units/ml penicillin and 100 g/ml streptomycin), 20 ng/ml EGF and 20 ng/ml FGF2 (Sigma-Aldrich, St Louis, MO) and cultured at 37 °C in a water-saturated atmosphere with 5% of CO2. Cultures were grown for 5 days until formation of neurospheres was observed. Neurospheres were washed twice with DMEM/F12 at 300 r.p.m for 3 min.

extract_protocol: Total RNA from BK and HOE treated, and untreated APPswe/PS1dE9 neurospheres was extracted using the RNAspin Mini Kit (GE Healthcare, UK), according to the manufacturer instructions. The RNA was treated with DNAse.

treatment_protocol: For neural differentiation, neurospheres were washed twice with DMEM/F12 medium following centrifugation for 3 minutes at 100xG and then were allowed to attach to poly-L-lysine and laminin precoated plastic flasks and cultured with DMEM/F-12, supplemented with 2% B-27, in the absence of FGF-2 and EGF. Progenitor cells were differentiated for 7 days in the incubator at 37°C with controlled humidity and 5% CO2. Neurospheres from APP/PS1 mice were submitted to different drug treatments on days 0, 3, and 6 of the differentiation phase. APP_WT neurospheres were maintained untreated; c neurospheres were treated with 1µM BK (Tocris Bioscience) and HOE_APP neurospheres were treated with 1µM HOE-140 (Tocris Bioscience). The drug concentrations were defined based on Pillat et al. 2016 (Pillat et al. 2016). On the seventh day of differentiation, RNAs from neurospheres were extracted to perform the microarray analysis.

value: Untreated differentiated NPCs from APPswe/PS1dE9 embryo telencephalon


title: H3K36me3_heart_E16_EC_cell_456


title: Naive_SM_Th2_Input_R2


title: CD11brGFP-Stroke-24h-1


title: H3K36me3_heart_E16_EC_cell_455


title: HOE_APP_vs_APP_WT_R1

description: Replicate 1 of 4: HOE treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant

value: HOE treated differentiated NPCs from APPswe/PS1dE9 embryo telencephalon


title: BK_APP_vs_APP_WT_R4

description: Replicate 4 of 4: BK treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant

value: BK treated differentiated NPCs from APPswe/PS1dE9 embryo telencephalon


title: BK_APP_vs_APP_WT_R3

description: Replicate 3 of 4: BK treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant


title: HOE_APP_vs_APP_WT_R2

description: Replicate 2 of 4: HOE treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant


title: BK_APP_vs_APP_WT_R2

description: Replicate 2 of 4: BK treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant


title: Naive_SM_Th2_Input_R1


title: APP_WT_vs_WT_R4

description: Replicate 4 of 4: APPswe/PS1dE9 mutant  vs. WT NPCs

source_name: WT cells

value: differentiated NPCs from wild-type embryo telencephalon

value: differentiated NPCs from APPswe/PS1dE9 embryo telencephalon


title: HOE_APP_vs_APP_WT_R3

description: Replicate 3 of 4: HOE treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant


title: APP_WT_vs_WT_R3

description: Replicate 3 of 4: APPswe/PS1dE9 mutant  vs. WT NPCs


title: Epidermis CD103+, donor 2018#C50

city: Huddinge

first: Ram Vinay

last: Pandey

state: Stockholm

address: Hälsovägen 7, Neo

department: Department of Medicine

country: Sweden

institute: Karolinska Institutet

description:
C50_3_Epidermis_CD103+
FACS-sorted skin CD8 Trm cells.

data_processing:
Pair-end reads were trimmed for low quality bases and removal of low-quality reads using ReadTools.
Trimmed reads were mapped to the Homo sapiens genome (GRCh37.87 assembly) using STAR (v2.5.3a) mapper.
The reads mapped in multiple genomic locations were eliminated by using Samtools (v1.4).
ATAC-seq low quality peaks such as blacklisted peaks were eliminated.
ATAC-seq peaks were identified by using the HOMER tool.
Assembly: hg19
Supplementary files format and content: HOMER peak file and bedGraph files.

source_name: CD69+ CD103+ CD49a- T cells

extract_protocol:
OmniATAC-seq with Tagment DNA Enzyme 1 (Illumina).
Amplification with NEBNext 2X high-fidelity PCR master mix followed by AMPure XP magnetic beads purification.

value: CD69+ CD103+ CD49a- T cells

tag: disease state

value: Healthy donor


title: KO_Th2_K9me3_R2


title: APP_WT_vs_WT_R2

description: Replicate 2 of 4: APPswe/PS1dE9 mutant  vs. WT NPCs


title: Epidermis CD49a+, donor 2018#C50

description:
C50_4_Epidermis_CD49a+
FACS-sorted skin CD8 Trm cells.

source_name: CD69+ CD103+ CD49a+ T cells

value: CD69+ CD103+ CD49a+ T cells


title: APP_WT_vs_WT_R1

description: Replicate 1 of 4: APPswe/PS1dE9 mutant  vs. WT NPCs


title: H3K36me3_heart_E16_EC_cell_453

value: heart

value: Fixed by methanol

value: H3K36me3, Active motif, Cat. 61101


title: Dermis CD103-, donor 2018#C50

description:
C50_1_Dermis_CD103-
FACS-sorted skin CD8 Trm cells.

source_name: CD69+ CD103- CD49a- T cells

value: CD69+ CD103- CD49a- T cells


title: KO_Th2_K9me3_R1

value: Spleen and lymph nodes


title: H3K36me3_heart_E16_EC_cell_454


title: Epidermis CD49a+, donor 2018#C41

description:
C41_B4_Epidermis_CD49a+
FACS-sorted skin CD8 Trm cells.


title: H3K36me3_heart_E16_EC_cell_452


title: Epidermis CD103+, donor 2018#C41

description:
C41_B3_Epidermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: Dermis CD103+, donor 2018#C41

description:
C41_B2_Dermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: KO_Th2_K4me3_R1

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells


title: Epidermis CD49a+, donor 2018#C37

description:
C37_B4_Epidermis_CD49a+
FACS-sorted skin CD8 Trm cells.


title: H3K36me3_heart_E16_EC_cell_450


title: Epidermis CD103+, donor 2018#C37

description:
C37_B3_Epidermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: Dermis CD103+, donor 2018#C37

description:
C37_B2_Dermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: Dermis CD103+, donor 2018#C50

description:
C50_2_Dermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: KO_Th2_K4me1_R2

value: CD4 T cells


title: Dermis CD103-, donor 2018#C37

description:
C37_B1_Dermis_CD103-
FACS-sorted skin CD8 Trm cells.


title: H3K36me3_heart_E16_EC_cell_449


title: Epidermis CD49a+, donor 2017#C23

description:
C23_10_Epidermis_CD49a+
FACS-sorted skin CD8 Trm cells.


title: Epidermis CD103+, donor 2017#C23

description:
C23_9_Epidermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: H3K36me3_heart_E16_EC_cell_448


title: CD8 T cells, Runx3_AE, Donor 5_E95

description:
RNA_5E_S12
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt

data_processing:
Pair-end reads were trimmed for low quality bases and removal of low-quality reads using ReadTools.
Trimmed reads were mapped to the Homo sapiens genome (GRCh37.87 assembly) using STAR (v2.5.3a) mapper.
The reads mapped in multiple genomic locations were eliminated by using Samtools (v1.4).
Read counts for features (exons) were generated using the featureCounts function from the Subread package (v 1.5.3).
Assembly: hg19
Supplementary files format and content: *_raw_gene_count_matrix.txt: Tab-delimited text files include raw read counts for each Sample.

source_name: CD8+ T cells

extract_protocol:
SMART-seq v4 Ultra Low Input RNA kit.
Nextera XT DNA Library Prep kit.

value: CD8+ T cells

value: Healthy donors

value: RUNX3 gene KO

value: In vitro Trm-like differentiation

tag: time

value: Day 14


title: Dermis CD103+, donor 2017#C23

description:
C23_8_Dermis_CD103+
FACS-sorted skin CD8 Trm cells.


title: Dermis CD103-, donor 2017#C23

description:
C23_7_Dermis_CD103-
FACS-sorted skin CD8 Trm cells.


title: H3K36me3_heart_E16_EC_cell_447


title: KO_Th2_K4me3_R2

value: Th2 conditions


title: KO_Th2_K27me3_R2


title: KO_Th2_K27me3_R1


title: CD8 T cells, Runx3_AE, Donor 4_E95

description:
RNA_5D_S7
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_446


title: KO_Th2_K27ac_R2


title: CD8 T cells, Runx3_AE, Donor 2_E93

description:
RNA_5B_S10
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_451


title: Dermis CD103-, donor 2018#C41

description:
C41_B1_Dermis_CD103-
FACS-sorted skin CD8 Trm cells.


title: H3K36me3_heart_E16_EC_cell_445


title: CD8 T cells, Runx3_AE, Donor 1_E93

description:
RNA_5A_S5
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: KO_Th2_K27ac_R1


title: CD8 T cells, Runx3_AD, Donor 5_E95

description:
RNA_4E_S11
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Runx3_AD, Donor 4_E95

description:
RNA_4D_S6
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_444


title: KO_Th2_K4me1_R1


title: KO_Th2_Input_R2


title: CD8 T cells, Runx3_AD, Donor 3_E95

description:
RNA_4C_S2
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Runx3_AD, Donor 2_E93

description:
RNA_4B_S9
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_443


title: CD8 T cells, Runx2_AC, Donor 5_E95

description:
RNA_3E_S10
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt

value: RUNX2 gene KO


title: CD8 T cells, Runx3_AD, Donor 1_E93

description:
RNA_4A_S4
FACS sorted and differentiated Trm-like cells upon RUNX3 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_442


title: CD8 T cells, Runx2_AC, Donor 3_E95

description:
RNA_3C_S1
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Runx2_AC, Donor 4_E95

description:
RNA_3D_S5
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: KO_Neutral_K9me3_R2

value: Neutral conditions


title: KO_Th2_Input_R1


title: CD8 T cells, Runx2_AC, Donor 2_E93

description:
RNA_3B_S8
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_441


title: CD8 T cells, Runx2_AB, Donor 5_E95

description:
RNA_2E_S9
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_440


title: KO_Neutral_K9me3_R1


title: KO_Neutral_K4me3_R2


title: H3K36me3_heart_E16_EC_cell_439


title: CD8 T cells, Runx2_AB, Donor 4_E95

description:
RNA_2D_S4
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Runx2_AB, Donor 3_E95

description:
RNA_2C_S12
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Runx2_AB, Donor 2_E93

description:
RNA_2B_S7
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_438


title: CD8 T cells, Runx2_AB, Donor 1_E93

description:
RNA_2A_S2
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Ctrl, Donor 5_E95

description:
RNA_1E_S8
FACS sorted and differentiated Trm-like cells upon ctrl gene KO.
RNAseq_KO_raw_gene_count_matrix.txt

value: ctrl gene KO


title: CD8 T cells, Ctrl, Donor 3_E95

description:
RNA_1C_S11
FACS sorted and differentiated Trm-like cells upon ctrl gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Runx2_AC, Donor 1_E93

description:
RNA_3A_S3
FACS sorted and differentiated Trm-like cells upon RUNX2 gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD8 T cells, Ctrl, Donor 1_E93

description:
RNA_1A_S1
FACS sorted and differentiated Trm-like cells upon ctrl gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD103+ CD49a+ Day 14 replicate 3

description:
14.RNA.D3.4_S10
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

source_name: CD69+ CD103+ CD49a+ CD8 T cells

value: CD69+ CD103+ CD49a+ CD8 T cells


title: H3K36me3_heart_E16_EC_cell_436

value: heart


title: KO_Neutral_K27me3_R1


title: KO_Neutral_K27me3_R2


title: CD103- CD49a+ Day 14 replicate 3

description:
15.RNA.D3.5_S12
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

source_name: CD69+ CD103- CD49a+ CD8 T cells

value: CD69+ CD103- CD49a+ CD8 T cells


title: H3K36me3_heart_E16_EC_cell_434

value: Fixed by methanol

value: H3K36me3, Active motif, Cat. 61101


title: KO_Neutral_K27ac_R2

value: Spleen and lymph nodes


title: H3K36me3_heart_E16_EC_cell_433


title: KO_Neutral_K4me1_R1

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells


title: CD103- CD49a- Day 14 replicate 3

description:
12.RNA.D3.2_S6
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

source_name: CD69+ CD103- CD49a- CD8 T cells

value: CD69+ CD103- CD49a- CD8 T cells


title: H3K36me3_heart_E16_EC_cell_528


title: H3K36me3_heart_E16_EC_cell_556


title: KO_Neutral_K4me3_R1

value: CD4 T cells


title: KO_Neutral_K27ac_R1


title: H3K36me3_heart_E16_EC_cell_435


title: CM Day 1 replicate 3

description:
11.RNA.D3.1_S4
FACS sorted CD8 Tcm cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

source_name: CD45RA- CD62L+ CD27+ CD8 T cells

value: CD45RA- CD62L+ CD27+ CD8 T cells

value: Healthy donors

value: Untreated

value: Day 1


title: KO_Neutral_K4me1_R2


title: H3K36me3_heart_E16_EC_cell_437


title: CD103+ CD49a- Day 14 replicate 3

description:
13.RNA.D3.3_S8
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

source_name: CD69+ CD103+ CD49a- CD8 T cells

value: CD69+ CD103+ CD49a- CD8 T cells

value: In vitro Trm-like differentiation

value: Day 14


title: CD103- CD49a+ Day 14 replicate 2

description:
10.RNA.D2.5_S2
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt


title: H3K36me3_heart_E16_EC_cell_432


title: KO_Neutral_Input_R2

value: Neutral conditions


title: CD8 T cells, Ctrl, Donor 4_E95

description:
RNA_1D_S3
FACS sorted and differentiated Trm-like cells upon ctrl gene KO.
RNAseq_KO_raw_gene_count_matrix.txt

value: CD8+ T cells

value: ctrl gene KO


title: CD103+ CDD49a+ Day 14 replicate 2

description:
9.RNA.D2.4_S15
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

value: CD69+ CD103+ CD49a+ CD8 T cells


title: CD8 T cells, Ctrl, Donor 2_E93

description:
RNA_1B_S6
FACS sorted and differentiated Trm-like cells upon ctrl gene KO.
RNAseq_KO_raw_gene_count_matrix.txt


title: CD103+ CD49a- Day 14 replicate 2

description:
8.RNA.D2.3_S13
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt


title: KO_Neutral_Input_R1


title: H3K36me3_heart_E16_EC_cell_431

value: heart

value: Fixed by methanol


title: CM Day 1 replicate 2

description:
6.RNA.D2.1_S9
FACS sorted CD8 Tcm cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt


title: CD103-cCD49a+ Day 14 replicate 1

description:
5.RNA.D1.5_S7
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

value: CD69+ CD103- CD49a+ CD8 T cells


title: H3K36me3_heart_E16_EC_cell_430

value: H3K36me3, Active motif, Cat. 61101


title: Het_Th2_K9me3_R2

value: Spleen and lymph nodes

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells

value: Th2 conditions


title: CD103- CD49a- Day 14 replicate 2

description:
7.RNA.D2.2_S11
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

value: CD69+ CD103- CD49a- CD8 T cells

value: Healthy donors


title: CD103+ CD49a+ Day 14 replicate 1

description:
4.RNA.D1.4_S5
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt


title: CD103+ CD49a- Day 14 replicate 1

description:
3.RNA.D1.3_S3
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt


title: Het_Th2_K9me3_R1

value: CD4 T cells


title: H3K36me3_heart_E16_EC_cell_429


title: CD103- CD49a- Day 14 replicate 1

description:
2.RNA.D1.2_S1
FACS sorted and differentiated Trm-like cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt


title: CM Day1 replicate 1

description:
1.RNA.D1.1_S14
FACS sorted CD8 Tcm cells.
RNAseq_in_vitro_raw_gene_count_matrix.txt

value: CD45RA- CD62L+ CD27+ CD8 T cells

value: Untreated

value: Day 1


title: mouse_PPARaKO_DMSO_72_0_na_220

city: Asheville

first: Melissa

middle: Marie

last: Heintz

state: NC

address: 31 College Place, Suite B118

institute: ToxStrategies

data_processing:
Sequencing reads are demultiplexed using the standard sequencing instrument software for each sample using the barcodes to give a FASTQ file for each
no adapter trimming for TempO-Seq fastqs, default settings for clusters passing filters
bcl2fastq v2.17.1.14 or v2.18.0.12 for demultiplexing
fastqs were aligned to a pseudo transcriptome using Bowtie allowing up to 2 mismatches
Assembly: probe-based targeted sequencing
Supplementary files format and content: comma-separated text files include raw count values for each gene_probe

source_name: primary hepatocytes

growth_protocol: Hepatocytes were isolated from the livers of 8 – 12 week-old male CD-1 mice (CD-1 IGS, strain code: 022) purchased from Charles River (Raleigh, NC) and 11 week-old male B6129SF2/J mice (stock #101045) and 11 week-old male PPARa-null mice (B6;129S4-Pparatm1Gonz/J, stock #008154) purchased from The Jackson Laboratory (Bar Harbor, ME). Rat hepatocytes were isolated from the livers of 8 – 12 week-old male Sprague Dawley (SD, strain code: 001) rats purchased from Charles River. Human hepatocytes were isolated from a pool of 10 donor livers (5 male and 5 female). Hepatocytes from all species/strains were isolated using a two-step enzymatic digestion of liver tissue as described in Mudra and Parkinson (2001).   Primary hepatocytes were plated in a collagen-sandwich configuration on 48-well plates. Hepatocytes were maintained in Modified Eagle's medium, Dr. Chee’s modification (MCM; Gibco, Grand Island, NY) supplemented with 11.5% NaHCO3 (Sigma Aldrich), 0.88% L-arginine (Sigma Aldrich), 3% L-glutamine (Sigma Aldrich), 0.05% thymidine (Sigma Aldrich), 1% (v/v) ITS+ (BD Biosciences, Bedford, MA), 1% (v/v)  penicillin/streptomycin (5,000 U/mL penicillin, 5,000 μg/mL streptomycin (Sigma Aldrich), and  0.001% 10 mM dexamethasone (Sigma Aldrich). Cell cultures were incubated in a humidified culture chamber (37 ± 2 °C at 95% relative humidity, 95/5% air/CO2).

extract_protocol:
Following treatment with HFPO-DA or positive controls (i.e., GW7647, rosiglitazone, acetaminophen or d-galactosamine) for 12, 24 or 72 h, hepatocytes were lysed using TempO-Seq® Enhanced Lysis Buffer and processed according to the TempO-Seq® protocol by BioSypder Technologies.
TempO-Seq® protocol by BioSypder Technologies

treatment_protocol: Using 48-well plates, CD-1, B6129SF2/J and PPARa-KO mouse hepatocytes were seeded at a density of 0.6 x 10^6 cells/mL, and rat and human hepatocytes were seeded at a density of 1.3 x 10^6 cells/mL. After a 24 h adaptation period, hepatocytes from each species/strain were treated for 12, 24 or 72 h with supplemented MCM media containing solvent control in the presence or absence of HFPO-DA (0.1, 5, 50 or 500 μM) or one of the following positive controls: GW7647 (0.01, 0.1, 1 or 10 μM), rosiglitazone (0.01, 0.1, 1 or 10 μM), acetaminophen (0.3, 1, 3 or 10 mM) or d-galactosamine (0.3, 1, 3 or 10 mM). Deionized water (1%) served as the solvent control for HFPO-DA and dimethylsulfoxide (DMSO, 0.1%; cell culture grade; Sigma Aldrich) served as the solvent control for the remaining test chemicals. Treatment solutions were replaced every 24 h. For each species/strain, treatment groups were performed in triplicate wells for 12 and 72 h treatment durations, and quadruplicate wells for the 24 h treatment duration.

value: PPARa-KO

value: primary hepatocytes

tag: chemical

value: DMSO

tag: concentration

value: solvent control

tag: concentration units

tag: exposure duration_(hours)


title: H3K36me3_heart_E16_EC_cell_428

value: heart


title: H3K36me3_heart_E16_EC_cell_427

value: Fixed by methanol


title: mouse_PPARaKO_DMSO_72_0_na_218


title: mouse_PPARaKO_DMSO_72_0_na_219


title: Het_Th2_K4me3_R2


title: Het_Th2_K4me1_R2


title: mouse_PPARaKO_Deionized_water_72_0_na_216


title: mouse_PPARaKO_Deionized_water_72_0_na_215


title: Het_Th2_K4me3_R1


title: H3K36me3_heart_E16_EC_cell_426


title: mouse_PPARaKO_Deionized_water_72_0_na_217


title: Het_Th2_K4me1_R1


title: H3K36me3_heart_E16_EC_cell_425


title: H3K36me3_heart_E16_EC_cell_424


title: mouse_PPARaKO_HFPO_DA_72_500_uM_212

value: uM


title: Het_Th2_K27me3_R2


title: Het_Th2_K27me3_R1


title: mouse_PPARaKO_HFPO_DA_72_50_uM_211


title: H3K36me3_heart_E16_EC_cell_422

value: H3K36me3, Active motif, Cat. 61101


title: Het_Th2_K27ac_R2

value: Spleen and lymph nodes


title: mouse_PPARaKO_HFPO_DA_72_50_uM_210


title: mouse_PPARaKO_Rosiglitzone_72_10_uM_208

value: Rosiglitzone


title: H3K36me3_heart_E16_EC_cell_421


title: mouse_PPARaKO_Rosiglitzone_72_10_uM_207


title: Het_Th2_K27ac_R1

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells

value: Th2 conditions


title: mouse_PPARaKO_Rosiglitzone_72_10_uM_206


title: mouse_PPARaKO_HFPO_DA_72_50_uM_209


title: BK_APP_vs_APP_WT_R1

description: Replicate 1 of 4: BK treated APPswe/PS1dE9 mutant  vs. Untreated APPswe/PS1dE9 mutant

value: BK treated differentiated NPCs from APPswe/PS1dE9 embryo telencephalon

value: Untreated differentiated NPCs from APPswe/PS1dE9 embryo telencephalon


title: mouse_PPARaKO_D_Galactosamine_72_10_mM_205

value: mM


title: Het_Th2_Input_R1

value: CD4 T cells


title: H3K36me3_heart_E16_EC_cell_420


title: mouse_PPARaKO_D_Galactosamine_72_10_mM_203


title: H3K36me3_heart_E16_EC_cell_419


title: Het_Neutral_K9me3_R2

value: Neutral conditions


title: mouse_PPARaKO_HFPO_DA_72_500_uM_214

value: PPARa-KO


title: H3K36me3_heart_E16_EC_cell_418


title: Het_Th2_Input_R2


title: mouse_PPARaKO_Acetominophen_72_10_mM_201

value: primary hepatocytes

value: Acetominophen


title: mouse_PPARaKO_HFPO_DA_72_500_uM_213


title: H3K36me3_heart_E16_EC_cell_423


title: H3K36me3_heart_E16_EC_cell_417


title: mouse_PPARaKO_Acetominophen_72_10_mM_202


title: H3K36me3_heart_E16_EC_cell_416


title: Het_Neutral_K9me3_R1


title: OC + Paeoniflorin #1

city: Busan

first: Haeseung

last: Lee

address: 63 Beon-gil 2, Busandaehag-ro, Geumjeong-gu

department: College of Pharmacy

country: South Korea

institute: Pusan National University

description: Thirty-eight-week-old Balb/c female mice were orally administered single compound treatment at a dose of 5mg/kg, five times a week for four weeks.

data_processing:
Initial evaluation of the quality of raw RNA-seq fastq file was conducted utilizing FASTQC (v1.9).
The BBduk module within the bbmap toolkit (v38.95) was conducted with specific parameters: k=13, ktrim=r, useshortkmers=t, mink=5, qtrim=t, trimq=10, and minlength=20 to eliminate adapter sequences and low-quality reads.
The cleaned reads were mapped to the mouse reference genome (build GRCm39) through the STAR aligner (v2.7.9a)
Transcript abundance per gene such as expected read count or Transcripts Per Million (TPM) was quantified by RSEM (v1.3.3) along with the gene structure file (GRCm39.104.gtf).
Assembly: GRCm39
Supplementary files format and content: tab-delimited text files include Expected counts, FPKM, and TPM values for each Sample

source_name: Ovary

growth_protocol: Thirty-eight-week-old Balb/c female mice were purchased from the Central Lab. Animal Inc.(Seoul, Korea). All mice were maintained on an ad libitum diet in a specific pathogen-free room under a 12-hour light-dark cycle. All mice handling and experimental procedures were approved by the Korea Institute of Oriental Medicine Institutional Animal Care and Use Committee (approval number 20-090).

extract_protocol:
Following compound administration for 4 weeks, to create a post-ovulatory state, mice were induced by intraperitoneal injection of 5 IU of pregnant mare serum gonadotropin (PMSG; HOR-272; Prospec, Rehovot, Israel), followed by an injection of 5 IU of human chorionic gonadotropin (hCG; HOR-250; Prospec) 48 hours later. Ovaries were removed from mice and weighed at 14h-16h post-hCG administration. The ovary was immediately preserved in liquid nitrogen for RNA sequencing.  Each left ovary (n=3) of a post-ovulation mouse was immersed in 300ul TRIzol (Invitrogen, Carlsbad, CA, USA) and homogenized using a disposable grinder (Biomasher II; 890863; LMS Co., Tokyo, Japan).
Total RNA was isolated using Trizol reagent (Invitrogen). The quality of purity and integrity of the extracted RNA samples were analyzed using a NanoDrop ND-2000 Spectrophotometer (Thermo Inc., DE, USA) and Agilent 2100 bioanalyzer (Agilent Technologies, Amstelveen, The Netherlands). RNA library was constructed using QuantSeq 3’ mRNA-Seq Library Prep Kit (Lexogen, Inc., Austria) according to the manufacturer’s instructions.

treatment_protocol: Mice were randomly divided into groups of n=3 each. Aged mice(38-week-old) were orally administered either vehicle (distilled water containing 0.5% Dimethyl sulfoxide) or each of the 39 single compounds at a dose of 5mg/kg, five times a week for four weeks.

value: Ovary

value: Balb/c

tag: Sex

value: Female

value: Wildtype

value: Paeoniflorin


title: mouse_PPARaKO_D_Galactosamine_72_10_mM_204

tag: cell type


title: mouse_PPARaKO_HFPO_DA_72_5_uM_198

value: uM


title: mouse_PPARaKO_HFPO_DA_72_5_uM_197


title: mouse_PPARaKO_Acetominophen_72_10_mM_200


title: H3K36me3_heart_E16_EC_cell_415

value: heart

value: Fixed by methanol

value: H3K36me3, Active motif, Cat. 61101


title: mouse_PPARaKO_Acetominophen_72_3_mM_193


title: H3K36me3_heart_E16_EC_cell_414


title: H3K36me3_heart_E16_EC_cell_413


title: mouse_PPARaKO_Acetominophen_72_3_mM_192


title: Het_Neutral_K4me3_R1

value: Spleen and lymph nodes

tag: cell line

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells


title: Het_Neutral_K4me1_R2

tag: treatment


title: mouse_PPARaKO_D_Galactosamine_72_3_mM_195

value: mM


title: mouse_PPARaKO_Acetominophen_72_3_mM_191


title: mouse_PPARaKO_D_Galactosamine_72_3_mM_194


title: H3K36me3_heart_E16_EC_cell_412

tag: developmental stage


title: Het_Neutral_K27me3_R2

tag: tissue

value: CD4 T cells


title: H3K36me3_heart_E16_EC_cell_411

tag: strain


title: mouse_PPARaKO_Rosiglitzone_72_1_uM_189

value: Rosiglitzone


title: mouse_PPARaKO_HFPO_DA_72_5_uM_199

value: PPARa-KO


title: mouse_PPARaKO_Rosiglitzone_72_1_uM_190

value: primary hepatocytes


title: Het_Neutral_K4me3_R2

value: Neutral conditions


title: mouse_PPARaKO_GW7647_72_1_uM_187


title: Het_Neutral_K27me3_R1


title: H3K36me3_heart_E16_EC_cell_410

tag: tissue preparation


title: mouse_PPARaKO_Rosiglitzone_72_1_uM_188


title: mouse_PPARaKO_D_Galactosamine_72_3_mM_196


title: mouse_PPARaKO_GW7647_72_1_uM_186


title: mouse_PPARaKO_GW7647_72_1_uM_185


title: H3K36me3_heart_E16_EC_cell_409

tag: chip antibody


title: Het_Neutral_K4me1_R1

tag: genotype


title: mouse_PPARaKO_D_Galactosamine_72_1_mM_184


title: Het_Neutral_K27ac_R1


title: mouse_PPARaKO_D_Galactosamine_72_1_mM_183


title: Het_Neutral_K27ac_R2


title: H3K36me3_heart_E16_EC_cell_408


title: Het_Neutral_Input_R2


title: H3K36me3_heart_E16_EC_cell_407


title: mouse_PPARaKO_Acetominophen_72_1_mM_181

value: Acetominophen


title: mouse_PPARaKO_Acetominophen_72_1_mM_180


title: Het_Neutral_Input_R1


title: mouse_PPARaKO_D_Galactosamine_72_0.3_mM_177


title: H3K36me3_heart_E16_EC_cell_405


title: mouse_PPARaKO_D_Galactosamine_72_0.3_mM_178


title: KO_Th2_R2

data_processing:
#STAR v2.4.0j
STAR -- genomeDir <Directory > -- runThreadN 8 -- readFilesIn <Input file rep1 lane1 >,< Input file rep1 lane2 > <Input file rep2 lane1 >,< Input file rep2 lane2 > -- outFileNamePrefix <Prefix > -- outSAMtype BAM SortedByCoordinate
# HTSeq v0.6.1 python -m HTSeq.scripts.count -f bam <BAM Input file > <GTF file > > <Count file output >
#DESeq2 (v1.20) in R (v3.3.2) for vsd.txt file creation
Assembly: mm10
Supplementary files format and content: vsd.txt: tab-delimited text file with normalized count matrix (genes vs. samples)
Supplementary files format and content: .count files: tab-delimited text files with raw counts of the respective sample

extract_protocol:
RNA was extracted from 106 cells using RNeasy mini kit (Qiagen) with a separate step for DNAse I digestion (Qiagen).
ERCC Spike-in control mix-1 (Life technologies) was added to each sample prior to processing (1μL of a 1:10 dilution of mix-1). The rRNA depletion and library construction was processed with the ScriptSeq Complete Gold Kit (Epicentre) according to the manufacturer’s instructions. The index for individual samples was added in order to multiplex 9 samples in each sequencing lane. The quality of libraries was assessed using a DNA1000 chip on the Bioanalyzer (Agilent) and the concentration was measured using the Qubit DNA assay. Sequencing was performed on the Illumina platform with HiSeq 2000 paired-end 100 bp sequence type.

value: Th2 conditions


title: KO_Th2_R1


title: mouse_PPARaKO_D_Galactosamine_72_0.3_mM_176


title: mouse_PPARaKO_Acetominophen_72_0.3_mM_175


title: H3K36me3_heart_E16_EC_cell_404


title: mouse_PPARaKO_Acetominophen_72_0.3_mM_173


title: Het_Th2_R2


title: mouse_PPARaKO_Rosiglitzone_72_0.1_uM_172


title: H3K36me3_heart_E16_EC_cell_403


title: mouse_PPARaKO_Acetominophen_72_0.3_mM_174


title: H3K36me3_heart_E16_EC_cell_402


title: Het_Th2_R1


title: mouse_PPARaKO_Rosiglitzone_72_0.1_uM_171


title: WT_Th2_R2

value: Wild type


title: mouse_PPARaKO_D_Galactosamine_72_1_mM_182


title: mouse_PPARaKO_Rosiglitzone_72_0.01_uM_169


title: mouse_PPARaKO_Acetominophen_72_1_mM_179


title: H3K36me3_heart_E16_EC_cell_401


title: mouse_PPARaKO_Rosiglitzone_72_0.1_uM_170


title: H3K36me3_heart_E16_EC_cell_406


title: WT_Th2_R1


title: mouse_PPARaKO_GW7647_72_0.1_uM_166


title: H3K36me3_heart_E16_EC_cell_400


title: mouse_PPARaKO_GW7647_72_0.1_uM_165


title: KO_Neutral_R2


title: KO_Neutral_R1


title: H3K36me3_heart_E16_EC_cell_399


title: TP9

city: Cincinnati

first: Timothy

last: Phoenix

state: OH

address: 231 Albert Sabin Way, MSB 3005M

department: Division of Pharmaceutical Sciences

institute: University of Cincinnati

data_processing:
bcl files were demultiplexed and converted to fastq files using bcl2fastq
fastq seqences were aligned to mm10 using Tophat
number of reads was calculated for each Entrez gene
differential expression analysis was performed using edgeR
Assembly: mm10
Supplementary files format and content: tab delimited raw counts with genes in rows and samples in columns

source_name: orthotopic mouse tumor

growth_protocol: control cortex or GFP-positive regions of orthotopically implanted mWnt-MB tumor samples were microdissected and frozen on dry ice.

extract_protocol:
RNA was isolated using the NucleoSpin RNA kit (Macherey-Nagel) and processed as per manufacturer’s instructions.
RNA libraries were prepared for sequencing using standard Illumina protocols

tag: background strain

value: CD1-nude host. Implanted cells from Blbp-Cre; Ctnnb1Ex3flx/flx; Trp53flx/flx; Pik3caE545K +/flx

value: MycT58A + Ctnnb1Ex3flx/flx; Trp53flx/flx; Pik3caE545K

value: Cerebellum


title: mouse_PPARaKO_GW7647_72_0.1_uM_164

value: uM


title: H3K36me3_heart_E16_EC_cell_398

source_name: E16.5 heart

value: heart

value: Fixed by methanol


title: mouse_PPARaKO_GW7647_72_0.01_uM_163


title: Het_Neutral_R2

value: Spleen and lymph nodes


title: TP8


title: H3K36me3_heart_E16_EC_cell_397

value: H3K36me3, Active motif, Cat. 61101


title: H3K36me3_heart_E16_EC_cell_396


title: Het_Neutral_R1

value: Primary LCMV TCRtg CD4+ Thy1.1+ cells


title: mouse_PPARaKO_GW7647_72_0.01_uM_162


title: mouse_PPARaKO_Rosiglitzone_72_0.01_uM_168


title: TP6

value: EV + Ctnnb1Ex3flx/flx; Trp53flx/flx; Pik3caE545K


title: mouse_PPARaKO_Rosiglitzone_72_0.01_uM_167

value: Rosiglitzone


title: TP7


title: WT_Neutral_R2

value: CD4 T cells


title: TP5


title: H3K36me3_heart_E16_EC_cell_394


title: WT_Neutral_R1


title: mouse_PPARaKO_HFPO_DA_72_0.1_uM_159

value: PPARa-KO

value: primary hepatocytes


title: mouse_PPARaKO_HFPO_DA_72_0.1_uM_160


title: mouse_PPARaKO_GW7647_72_0.01_uM_161


title: TP4


title: Naive_SM_Th2_R2


title: H3K36me3_heart_E16_EC_cell_393


title: TP3

source_name: Normal cerebellum


title: Naive_SM_Th2_R1

source_name: Spleen and lymph nodes


title: mouse_PPARaKO_GW7647_72_10_uM_157


title: TP2


title: H3K36me3_heart_E16_EC_cell_392


title: mouse_PPARaKO_GW7647_72_10_uM_156


title: H3K36me3_heart_E16_EC_cell_391


title: TP1


title: H3K36me3_heart_E16_EC_cell_390


title: mLiverWT2

city: Orlando

first: Antonis

middle: S

last: Zervos

state: FL

address: 12722 Research Parkway

department: Burnett School of Biomedical Science

institute: University of Central Florida

data_processing:
Read counts in Library were examined before and after normalization. The normalized read counts were used to accurately determine differentially expressed genes.
Data quality assessments were performed to detect any samples that are not representative of their group and my affect the quality of the analysis
The differentially expressed genes were sorted by their adjusted p-value (
Significantly differentially expressed gene were clustered by their gene ontology and enrichment was tested using Fisher exact test.
Heatmaps of the top fifty, as well as genes specifically involved in fatty acid metabolism, lipid, and phospholipid biosynthesis metabolomic processes, were analyzed using RStudio.
Assembly: Using DESeq2, a comparison of gene expression between the defined groups of samples was performed. The Wald test was used to generate p-values and log2 fold changes. Genes with an adjusted P value < 0.01 (p < 0.01) and absolute log2 fold change > 1 were labeled as differentially expressed genes.
Supplementary files format and content: The differentially expressed genes involved in fatty acids biosynthesis and metabolism were used to generate a heatmap using the Heatmap2 software
Supplementary files format and content: Genes with an adjusted P value < 0.01 (p < 0.01) and absolute log2 fold change > 1 were labeled as differentially expressed genes.  Significantly differentially expressed genes were clustered by their gene ontology and the enrichment of gene ontology terms was tested using Fisher exact test.

source_name: Liver

extract_protocol:
RNA-sequencingfor gene profiling expression of protein-coding sequences (mRNA) was performed using liver tissues from Mul1(+/+) and Mul1(-/-) mice on HFD (n=3 per group). Approximately 100 mg of tissue was used for cDNA library construction, DNA sequencing, and data analysis (GENEWIZ Azenta Life Sciences).
Using DESeq2, a comparison of gene expression between the defined groups of samples was performed. The Wald test was used to generate p-values and log2 fold changes.

treatment_protocol: Liver tissue obtained from Mul1(+/+) and Mul1(-/-) mice kept on an HFD for 16 weeks

value: Liver

value: hepatocytes

value: WT

tag: diet

value: HFD


title: mLiverWT3


title: mouse_PPARaKO_GW7647_72_10_uM_155


title: H3K36me3_heart_E16_EC_cell_395


title: mouse_PPARaKO_D_Galactosamine_24_10_mM_154

value: mM


title: H3K36me3_heart_E16_EC_cell_389


title: mouse_PPARaKO_HFPO_DA_72_0.1_uM_158


title: mLiverKO3

value: KO


title: H3K36me3_heart_E16_EC_cell_388


title: mLiverWT1


title: human_DMSO_72_0_na_A02

value: 10 donors pooled

value: DMSO

value: solvent control


title: human_DMSO_72_0_na_A03


title: mLiverKO1


title: mouse_PPARaKO_D_Galactosamine_24_10_mM_152


title: human_Deionized_water_72_0_na_F06


title: H3K36me3_heart_E16_EC_cell_387

value: heart

value: Fixed by methanol


title: H3K36me3_heart_E16_EC_cell_386

value: H3K36me3, Active motif, Cat. 61101


title: human_Deionized_water_72_0_na_F05


title: mouse_PPARaKO_D_Galactosamine_24_10_mM_153


title: mouse_PPARaKO_Acetominophen_24_10_mM_150

value: Acetominophen


title: ATAC_Low_Gln_2

city: Shanghai

first: Ningning

last: Niu

address: 160 Pu Jian Road, Shanghai

department: Clinical Stem Cell Research Center

institute: Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital

description: ATAC-LowGln-remove batch effects

data_processing:
Raw FASTQ reads were trimmed adapters generated by Trim Galore (v. 0.6.6)
then aligned to the mm10 reference genome through Bowtie2 (v.2.4.2) with the parameters --very-sensitive -X 2000. then aligned to the mm10 reference genome through Bowtie2 (v.2.4.2) with the parameters --very-sensitive -X 2000.
ATAC-seq accessible regions were called using MACS2 v 2.2.7.1 with the following parameters: --nomodel --shift -100 --extsize 200 -format BAMPE -p 0.01.
we used bedtools(v2.29.2) to remove batch effects
Assembly: mm10
Supplementary files format and content: tab-delimited text files include callinng peaks(cutoff p0.01) for each Sample.

source_name: KPC1199 cells

extract_protocol:
Briefly, tumor cell were generated and collected after 72 hours of glutamine starvation.The ATAC-seq was performed according to the TruePrep Tagment Enzyme for ATACseq kit (TD501, Vazyme).
DNA libraries were constructed following the manufacturer’s instructions of the Trueprep index kit v2 (TD202, Vazyme) .

value: KPC1199 cells

value: pancreatic tumor cells

value: 0.4 mmol/L gln


title: H3K36me3_heart_E16_EC_cell_385


title: ATAC_Low_Gln_1

description: ATAC-LowGln-remove batch effects


title: mouse_PPARaKO_D_Galactosamine_24_10_mM_151

value: PPARa-KO

value: primary hepatocytes


title: human_Deionized_water_72_0_na_F04


title: H3K36me3_heart_E16_EC_cell_384


title: mLiverKO2

value: Liver

value: hepatocytes


title: mouse_PPARaKO_Acetominophen_24_10_mM_149


title: human_DMSO_72_0_na_A01


title: mouse_PPARaKO_Acetominophen_24_10_mM_148


title: ATAC_Cont_2

description: ATAC-Cont-remove batch effects

value: 2 mmol/L gln


title: human_HFPO_DA_72_500_uM_A06

value: uM


title: ATAC_Cont_1

description: ATAC-Cont-remove batch effects


title: human_HFPO_DA_72_500_uM_A05


title: mouse_PPARaKO_Acetominophen_24_10_mM_147

value: mM


title: H3K36me3_heart_E16_EC_cell_382


title: mouse_PPARaKO_D_Galactosamine_24_3_mM_146


title: mouse_PPARaKO_D_Galactosamine_24_3_mM_145


title: human_HFPO_DA_72_50_uM_H03

value: 10 donors pooled


title: human_HFPO_DA_72_500_uM_A04


title: 4-P007-TLK1_S4

city: Bethesda

first: Uma

middle: T

last: Shankavaram

state: MD

address: 9000 Rockville Pike

department: NCI

institute: NIH

data_processing:
Cleaned reads were obtained by Trim Galore and FASTQ sequences aligned to the hg38 genome build followed by BCFtools for variant calling and alternate allele frequency of the sequenced genes. A filter with quality score >=20 was used to remove variants likely observed purely by chance.
Assembly: hg38

source_name: lymphoblastoid

extract_protocol:
Genomic DNA was subjected to 35 cycles of PCR amplification using Q5 High-Fidelity DNA Polymerase (New England Biolabs) with primers that allow for the amplification of the region containing the variants of interest. PCR products were run in a 2% agarose gel and purified using the Nucleospin Gel and PCR clean-up kit (Macherey-Nagel) following manufacturer’s instructions. Briefly, bands were carefully excised with a clean scalpel, weighed and incubated at 50°C for 10 minutes with the corresponding amount of NTI Buffer. Next, DNA was bound at a silica membrane by placing it into a column provided by the kit. The membrane was then washed twice with NT3 buffer and dried by incubating at 70°C for 3 minutes. DNA was eluted in NE buffer and quantified using a DS-11 Spectrophotometer (DeNovix). PCR products were sequenced using a NextSeq (Illumina).
DNA libraries were prepared using the Nextera XT DNA Library Prep kit (Illumina) following manufacturer’s instructions. Sequencing of PCR amplicons was carried out using the MiSeq Nano kit sequencing system (Illumina) with 150 bp paired-end (PE) reads.

value: lymphoblastoid

value: PRO


title: H3K36me3_heart_E16_EC_cell_381

value: heart


title: human_HFPO_DA_72_50_uM_H02


title: mouse_PPARaKO_D_Galactosamine_24_3_mM_144


title: 5-P007-MDM1_S5


title: 2-P006-MDM1_S2

value: SIB


title: human_HFPO_DA_72_50_uM_H01


title: H3K36me3_heart_E16_EC_cell_380

value: Fixed by methanol

value: H3K36me3, Active motif, Cat. 61101


title: H3K36me3_heart_E16_EC_cell_378


title: 1-P006-TLK1_S1


title: mouse_PPARaKO_D_Galactosamine_24_3_mM_143


title: H3K36me3_heart_E16_EC_cell_379


title: H3K36me3_heart_E16_EC_cell_383


title: mouse_PPARaKO_Acetominophen_24_3_mM_142

value: Acetominophen


title: human_Rosiglitzone_72_10_uM_E05

value: Rosiglitzone


title: human_Rosiglitzone_72_10_uM_E04


title: human_Rosiglitzone_72_10_uM_E06


title: H3K36me3_heart_E16_EC_cell_377


title: H3K36me3_heart_E16_EC_cell_375


title: H3K36me3_heart_E16_EC_cell_376


title: human_GW7647_72_10_uM_E03


title: H3K36me3_heart_E16_EC_cell_374


title: mouse_PPARaKO_Acetominophen_24_3_mM_139


title: human_GW7647_72_10_uM_E02


title: H3K36me3_heart_E16_EC_cell_373


title: mouse_PPARaKO_D_Galactosamine_24_1_mM_138


title: rat_DMSO_72_0_na_219

organism: Rattus norvegicus

value: Sprague Dawley

value: DMSO

value: solvent control


title: H3K36me3_heart_E16_EC_cell_372


title: rat_DMSO_72_0_na_218

value: primary hepatocytes


title: human_GW7647_72_10_uM_E01


title: human_D_Galactosamine_72_10_mM_F09


title: mouse_PPARaKO_Acetominophen_24_3_mM_141

value: PPARa-KO


title: rat_Deionized_water_72_0_na_217


title: human_D_Galactosamine_72_10_mM_F08


title: mouse_PPARaKO_D_Galactosamine_24_1_mM_135


title: H3K36me3_heart_E16_EC_cell_370


title: rat_Deionized_water_72_0_na_216


title: human_D_Galactosamine_72_10_mM_F07


title: H3K36me3_heart_E16_EC_cell_369


title: rat_Deionized_water_72_0_na_215


title: rat_DMSO_72_0_na_220


title: human_Acetominophen_72_10_mM_B09


title: mouse_PPARaKO_Acetominophen_24_3_mM_140


title: H3K36me3_heart_E16_EC_cell_368


title: mouse_PPARaKO_D_Galactosamine_24_0.3_mM_133


title: human_Acetominophen_72_10_mM_B08


title: rat_HFPO_DA_72_500_uM_214


title: mouse_PPARaKO_D_Galactosamine_24_1_mM_137


title: H3K36me3_heart_E16_EC_cell_371


title: mouse_PPARaKO_D_Galactosamine_24_1_mM_136


title: H3K36me3_heart_E16_EC_cell_367


title: human_Acetominophen_72_10_mM_B07


title: rat_HFPO_DA_72_500_uM_213


title: H3K36me3_heart_E16_EC_cell_366


title: mouse_PPARaKO_D_Galactosamine_24_0.3_mM_131


title: mouse_PPARaKO_D_Galactosamine_24_0.3_mM_132


title: rat_HFPO_DA_72_50_uM_211


title: mouse_PPARaKO_DMSO_24_0_na_130


title: rat_HFPO_DA_72_500_uM_212


title: human_HFPO_DA_72_5_uM_G02


title: mouse_PPARaKO_D_Galactosamine_24_0.3_mM_134


title: H3K36me3_heart_E16_EC_cell_365


title: mouse_PPARaKO_DMSO_24_0_na_129


title: H3K36me3_heart_E16_EC_cell_364


title: mouse_PPARaKO_DMSO_24_0_na_128


title: human_HFPO_DA_72_5_uM_G01


title: H3K36me3_heart_E16_EC_cell_363


title: human_HFPO_DA_72_5_uM_G03


title: human_D_Galactosamine_72_3_mM_E09


title: mouse_PPARaKO_DMSO_24_0_na_127


title: human_D_Galactosamine_72_3_mM_E08


title: H3K36me3_heart_E16_EC_cell_362


title: H3K36me3_heart_E16_EC_cell_361


title: rat_HFPO_DA_72_50_uM_210


title: rat_Rosiglitzone_72_10_uM_208


title: mouse_PPARaKO_Deionized_water_24_0_na_126


title: rat_Rosiglitzone_72_10_uM_207


title: H3K36me3_heart_E16_EC_cell_360


title: human_D_Galactosamine_72_3_mM_E07


title: rat_Rosiglitzone_72_10_uM_206


title: rat_HFPO_DA_72_50_uM_209


title: human_Acetominophen_72_3_mM_A09


title: H3K36me3_heart_E16_EC_cell_359


title: rat_GW7647_72_10_uM_205


title: human_Acetominophen_72_3_mM_A08


title: H3K36me3_heart_E16_EC_cell_358


title: mouse_PPARaKO_Deionized_water_24_0_na_125


title: human_Acetominophen_72_3_mM_A07


title: H3K36me3_heart_E16_EC_cell_357


title: mouse_PPARaKO_HFPO_DA_24_500_uM_122


title: rat_GW7647_72_10_uM_203


title: mouse_PPARaKO_HFPO_DA_24_500_uM_121


title: H3K36me3_heart_E16_EC_cell_356


title: mouse_PPARaKO_Deionized_water_24_0_na_124


title: rat_D_Galactosamine_72_10_mM_202


title: human_Rosiglitzone_72_1_uM_D05


title: rat_GW7647_72_10_uM_204


title: mouse_PPARaKO_HFPO_DA_24_500_uM_120


title: rat_D_Galactosamine_72_10_mM_201


title: H3K36me3_heart_E16_EC_cell_355


title: rat_D_Galactosamine_72_10_mM_200


title: human_GW7647_72_1_uM_D03


title: mouse_PPARaKO_HFPO_DA_24_500_uM_119


title: H3K36me3_heart_E16_EC_cell_354


title: human_Rosiglitzone_72_1_uM_D04


title: mouse_PPARaKO_HFPO_DA_24_50_uM_118


title: rat_Acetominophen_72_10_mM_199


title: H3K36me3_heart_E16_EC_cell_353


title: rat_Acetominophen_72_10_mM_198


title: H3K36me3_heart_E16_EC_cell_352


title: human_GW7647_72_1_uM_D01


title: mouse_PPARaKO_HFPO_DA_24_50_uM_117


title: mouse_PPARaKO_HFPO_DA_24_50_uM_116


title: human_GW7647_72_1_uM_D02


title: human_Rosiglitzone_72_1_uM_D06


title: mouse_PPARaKO_Deionized_water_24_0_na_123


title: H3K36me3_heart_E16_EC_cell_350


title: human_D_Galactosamine_72_1_mM_D09


title: rat_Acetominophen_72_10_mM_197


title: mouse_PPARaKO_HFPO_DA_24_50_uM_115


title: rat_HFPO_DA_72_5_uM_196


title: rat_HFPO_DA_72_5_uM_195


title: mouse_PPARaKO_Rosiglitzone_24_10_uM_114


title: human_D_Galactosamine_72_1_mM_D08


title: human_D_Galactosamine_72_1_mM_D07


title: H3K36me3_heart_E16_EC_cell_349


title: H3K36me3_heart_E16_EC_cell_348


title: mouse_PPARaKO_Rosiglitzone_24_10_uM_113


title: rat_HFPO_DA_72_5_uM_194


title: mouse_PPARaKO_Rosiglitzone_24_10_uM_112


title: H3K36me3_heart_E16_EC_cell_347


title: rat_D_Galactosamine_72_3_mM_193


title: mouse_PPARaKO_Rosiglitzone_24_10_uM_111


title: human_Acetominophen_72_1_mM_H05


title: rat_D_Galactosamine_72_3_mM_192


title: CHD011-17

type: genomic

city: Perugia

first: Cristina

last: Mecucci

address: Piazzale Menghini n.9

department: Department of Medicine, Hematology and Bone Marrow Transplantation Unit

country: Italy

institute: University of Perugia

hyb_protocol: DNA was restriction digested, ligated, PCR amplified, fragmented, labeled and hybridized to each array according to the manufacturer's instructions

scan_protocol: The Arrays were then washed using Affymetrix fluidics stations, and scanned using the Gene Chip Scanner 3000 7G

data_processing: Protocol was supported by Affymetrix GeneChip Command Console (AGCC) software. Analysis was performed through Affymetrix Chromosome Analysis 4.0 (ChAS) software with filters set at 200 Kb for Copy Number Alterations (CNAs) and 10 Mb for copy neutral Loss Of Heterozygosity (cnLOH). Our data refer to NetAffx Build 32.3 (hg19) database

label_protocol: As per manufacturer (Affymetrix)

extract_protocol: DNA were extracted from bone marrow cells of patients using All Prep DNA/RNA Mini Kit (Qiagen). DNA quality and quantity was assessed using a Nanodrop Spectrophotometer, Bioanalyzer and/or Tapestation visualization (Agilent 2100 Bioanalyzer) and agarose gel electrophoresis

value: Unsorted Bone Marrow Cells


title: human_Acetominophen_72_1_mM_H04


title: H3K36me3_heart_E16_EC_cell_351


title: H3K36me3_heart_E16_EC_cell_345


title: rat_D_Galactosamine_72_3_mM_191


title: human_D_Galactosamine_72_0.3_mM_C09


title: mouse_PPARaKO_GW7647_24_10_uM_109

value: uM


title: rat_Acetominophen_72_3_mM_190

value: mM


title: CHD053-20


title: human_D_Galactosamine_72_0.3_mM_C07

value: 10 donors pooled


title: rat_Acetominophen_72_3_mM_189


title: H3K36me3_heart_E16_EC_cell_342


title: human_D_Galactosamine_72_0.3_mM_C08


title: H3K36me3_heart_E16_EC_cell_343


title: mouse_PPARaKO_GW7647_24_10_uM_108


title: rat_Acetominophen_72_3_mM_188


title: mouse_PPARaKO_GW7647_24_10_uM_107


title: human_Acetominophen_72_0.3_mM_G06


title: mouse_PPARaKO_HFPO_DA_24_5_uM_106


title: H3K36me3_heart_E16_EC_cell_341


title: H3K36me3_heart_E16_EC_cell_344


title: rat_Rosiglitzone_72_1_uM_187


title: H3K36me3_heart_E16_EC_cell_340


title: rat_Rosiglitzone_72_1_uM_186


title: mouse_PPARaKO_HFPO_DA_24_5_uM_105


title: human_Acetominophen_72_0.3_mM_G05


title: mouse_PPARaKO_HFPO_DA_24_5_uM_104


title: human_Acetominophen_72_0.3_mM_G04


title: rat_Rosiglitzone_72_1_uM_185


title: CHD015-17


title: H3K36me3_heart_E16_EC_cell_338


title: human_Rosiglitzone_72_0.1_uM_C06


title: H3K36me3_heart_E16_EC_cell_346


title: mouse_PPARaKO_GW7647_24_10_uM_110


title: rat_GW7647_72_1_uM_184


title: H3K36me3_heart_E16_EC_cell_337


title: human_Rosiglitzone_72_0.1_uM_C05


title: human_Rosiglitzone_72_0.1_uM_C04


title: mouse_PPARaKO_Rosiglitzone_24_1_uM_102


title: rat_GW7647_72_1_uM_182


title: H3K36me3_heart_E16_EC_cell_336


title: human_Rosiglitzone_72_0.01_uM_B06


title: CHD038-20


title: mouse_PPARaKO_Rosiglitzone_24_1_uM_100


title: rat_GW7647_72_1_uM_183


title: H3K36me3_heart_E16_EC_cell_339


title: mouse_PPARaKO_Rosiglitzone_24_1_uM_99


title: human_Rosiglitzone_72_0.01_uM_B05


title: rat_D_Galactosamine_72_1_mM_181


title: human_Rosiglitzone_72_0.01_uM_B04


title: rat_D_Galactosamine_72_1_mM_180


title: H3K36me3_heart_E16_EC_cell_335


title: H3K36me3_heart_E16_EC_cell_333


title: mouse_PPARaKO_GW7647_24_1_uM_98


title: H3K36me3_heart_E16_EC_cell_334


title: human_GW7647_72_0.1_uM_C03


title: mouse_PPARaKO_HFPO_DA_24_5_uM_103


title: rat_Acetominophen_72_1_mM_178


title: human_GW7647_72_0.1_uM_C02


title: H3K36me3_heart_E16_EC_cell_332


title: mouse_PPARaKO_GW7647_24_1_uM_97


title: H3K36me3_heart_E16_EC_cell_331


title: mouse_PPARaKO_Rosiglitzone_24_1_uM_101


title: mouse_PPARaKO_GW7647_24_1_uM_96


title: mouse_PPARaKO_GW7647_24_1_uM_95


title: human_GW7647_72_0.1_uM_C01


title: H3K36me3_heart_E16_EC_cell_330


title: human_GW7647_72_0.01_uM_B03


title: mouse_PPARaKO_Acetominophen_24_1_mM_94


title: H3K36me3_heart_E16_EC_cell_329


title: human_Acetominophen_72_1_mM_H06


title: rat_D_Galactosamine_72_0.3_mM_175


title: rat_D_Galactosamine_72_1_mM_179


title: mouse_PPARaKO_Acetominophen_24_1_mM_93


title: rat_D_Galactosamine_72_0.3_mM_174


title: human_GW7647_72_0.01_uM_B02


title: H3K36me3_heart_E16_EC_cell_327


title: human_GW7647_72_0.01_uM_B01


title: H3K36me3_heart_E16_EC_cell_328


title: rat_Acetominophen_72_0.3_mM_172


title: rat_D_Galactosamine_72_0.3_mM_173


title: mouse_PPARaKO_Acetominophen_24_1_mM_92


title: H3K36me3_heart_E16_EC_cell_326


title: mouse_PPARaKO_Acetominophen_24_1_mM_91


title: human_HFPO_DA_72_0.1_uM_F02


title: human_HFPO_DA_72_0.1_uM_F03


title: H3K36me3_heart_E16_EC_cell_325


title: rat_Acetominophen_72_0.3_mM_171


title: mouse_PPARaKO_Acetominophen_24_0.3_mM_90


title: rat_Acetominophen_72_1_mM_177


title: rat_Acetominophen_72_1_mM_176


title: H3K36me3_heart_E16_EC_cell_324


title: mouse_PPARaKO_Acetominophen_24_0.3_mM_89


title: rat_Acetominophen_72_0.3_mM_170


title: human_D_Galactosamine_24_10_mM_F04


title: H3K36me3_heart_E16_EC_cell_323


title: mouse_PPARaKO_Acetominophen_24_0.3_mM_87


title: human_D_Galactosamine_24_10_mM_F03


title: human_D_Galactosamine_24_10_mM_F02


title: H3K36me3_heart_E16_EC_cell_322


title: rat_Rosiglitzone_72_0.1_uM_168


title: H3K36me3_heart_E16_EC_cell_321


title: mouse_PPARaKO_Rosiglitzone_24_0.1_uM_86


title: rat_Rosiglitzone_72_0.1_uM_167


title: H3K36me3_heart_E16_EC_cell_320


title: mouse_PPARaKO_Rosiglitzone_24_0.1_uM_85


title: human_D_Galactosamine_24_10_mM_F01


title: human_HFPO_DA_72_0.1_uM_F01


title: H3K36me3_heart_E16_EC_cell_318


title: mouse_PPARaKO_Rosiglitzone_24_0.1_uM_83


title: mouse_PPARaKO_Rosiglitzone_24_0.1_uM_84


title: human_Acetominophen_24_10_mM_B04


title: rat_Rosiglitzone_72_0.01_uM_165


title: H3K36me3_heart_E16_EC_cell_319


title: human_Acetominophen_24_10_mM_B03


title: rat_Rosiglitzone_72_0.01_uM_164


title: rat_Rosiglitzone_72_0.01_uM_166


title: human_Acetominophen_24_10_mM_B02


title: mouse_PPARaKO_Acetominophen_24_0.3_mM_88


title: mouse_PPARaKO_Rosiglitzone_24_0.01_uM_82


title: rat_GW7647_72_0.1_uM_163


title: H3K36me3_heart_E16_EC_cell_317


title: rat_Rosiglitzone_72_0.1_uM_169


title: H3K36me3_heart_E16_EC_cell_316


title: mouse_PPARaKO_Rosiglitzone_24_0.01_uM_81


title: human_Acetominophen_24_10_mM_B01


title: human_D_Galactosamine_24_3_mM_E04


title: human_D_Galactosamine_24_3_mM_E03


title: rat_GW7647_72_0.1_uM_162


title: rat_GW7647_72_0.1_uM_161


title: mouse_PPARaKO_Rosiglitzone_24_0.01_uM_80


title: rat_GW7647_72_0.01_uM_160


title: H3K36me3_heart_E16_EC_cell_313


title: human_D_Galactosamine_24_3_mM_E02


title: mouse_PPARaKO_GW7647_24_0.1_uM_78


title: H3K36me3_heart_E16_EC_cell_314


title: mouse_PPARaKO_Rosiglitzone_24_0.01_uM_79


title: rat_GW7647_72_0.01_uM_159


title: H3K36me3_heart_E16_EC_cell_311


title: human_D_Galactosamine_24_3_mM_E01


title: H3K36me3_heart_E16_EC_cell_312


title: rat_GW7647_72_0.01_uM_158


title: rat_HFPO_DA_72_0.1_uM_157


title: rat_HFPO_DA_72_0.1_uM_156


title: mouse_PPARaKO_GW7647_24_0.1_uM_75


title: mouse_PPARaKO_GW7647_24_0.1_uM_76


title: human_Acetominophen_24_3_mM_A03


title: H3K36me3_heart_E16_EC_cell_309


title: human_Acetominophen_24_3_mM_A02


title: H3K36me3_heart_E16_EC_cell_310


title: H3K36me3_heart_E16_EC_cell_315


title: rat_HFPO_DA_72_0.1_uM_155


title: human_Acetominophen_24_3_mM_A01


title: mouse_PPARaKO_GW7647_24_0.01_uM_73


title: mouse_PPARaKO_GW7647_24_0.01_uM_74


title: H3K36me3_heart_E16_EC_cell_308


title: rat_D_Galactosamine_24_10_mM_154


title: human_D_Galactosamine_24_1_mM_D04


title: human_Acetominophen_24_3_mM_A04


title: mouse_PPARaKO_GW7647_24_0.01_uM_72


title: mouse_PPARaKO_GW7647_24_0.1_uM_77


title: rat_D_Galactosamine_24_10_mM_152


title: human_D_Galactosamine_24_1_mM_D03


title: H3K36me3_heart_E16_EC_cell_306


title: mouse_PPARaKO_GW7647_24_0.01_uM_71


title: rat_D_Galactosamine_24_10_mM_153


title: human_D_Galactosamine_24_1_mM_D02


title: H3K36me3_heart_E16_EC_cell_305


title: mouse_PPARaKO_HFPO_DA_24_0.1_uM_70


title: human_D_Galactosamine_24_1_mM_D01


title: H3K36me3_heart_E16_EC_cell_304


title: human_D_Galactosamine_24_0.3_mM_C04


title: rat_Acetominophen_24_10_mM_150


title: mouse_PPARaKO_HFPO_DA_24_0.1_uM_69


title: mouse_PPARaKO_HFPO_DA_24_0.1_uM_68


title: H3K36me3_heart_E16_EC_cell_303


title: human_D_Galactosamine_24_0.3_mM_C03


title: rat_Acetominophen_24_10_mM_149


title: H3K36me3_heart_E16_EC_cell_307


title: H3K36me3_heart_E16_EC_cell_302


title: mouse_PPARaKO_HFPO_DA_24_0.1_uM_67


title: rat_Acetominophen_24_10_mM_148


title: human_D_Galactosamine_24_0.3_mM_C02


title: H3K36me3_heart_E16_EC_cell_301


title: rat_Acetominophen_24_10_mM_147


title: human_D_Galactosamine_24_0.3_mM_C01


title: mouse_PPARaKO_DMSO_12_0_na_66


title: rat_D_Galactosamine_24_10_mM_151


title: mouse_PPARaKO_DMSO_12_0_na_65


title: H3K36me3_heart_E16_EC_cell_300


title: rat_D_Galactosamine_24_3_mM_146


title: human_DMSO_24_0_na_A04


title: rat_D_Galactosamine_24_3_mM_145


title: mouse_PPARaKO_DMSO_12_0_na_64


title: H3K36me3_heart_E16_EC_cell_299


title: H3K36me3_heart_E16_EC_cell_298


title: mouse_PPARaKO_Deionized_water_12_0_na_63


title: H3K36me3_heart_E16_EC_cell_297


title: human_DMSO_24_0_na_A01


title: rat_D_Galactosamine_24_3_mM_143


title: mouse_PPARaKO_Deionized_water_12_0_na_61


title: H3K36me3_heart_E16_EC_cell_296


title: rat_Acetominophen_24_3_mM_142


title: human_Deionized_water_24_0_na_F08


title: human_Deionized_water_24_0_na_F07


title: mouse_PPARaKO_HFPO_DA_12_500_uM_60


title: H3K36me3_heart_E16_EC_cell_295


title: mouse_PPARaKO_HFPO_DA_12_500_uM_59


title: human_DMSO_24_0_na_A03


title: H3K36me3_heart_E16_EC_cell_294


title: mouse_PPARaKO_HFPO_DA_12_500_uM_58


title: human_Deionized_water_24_0_na_F05


title: human_DMSO_24_0_na_A02


title: H3K36me3_heart_E16_EC_cell_292


title: human_Deionized_water_24_0_na_F06


title: rat_D_Galactosamine_24_3_mM_144


title: mouse_PPARaKO_HFPO_DA_12_50_uM_57


title: mouse_PPARaKO_HFPO_DA_12_50_uM_56


title: mouse_PPARaKO_Deionized_water_12_0_na_62


title: human_HFPO_DA_24_500_uM_A08


title: H3K36me3_heart_E16_EC_cell_291


title: rat_D_Galactosamine_24_1_mM_138


title: rat_Acetominophen_24_3_mM_141


title: H3K36me3_heart_E16_EC_cell_290


title: mouse_PPARaKO_HFPO_DA_12_50_uM_55


title: human_HFPO_DA_24_500_uM_A06


title: rat_D_Galactosamine_24_1_mM_136


title: H3K36me3_heart_E16_EC_cell_289


title: mouse_PPARaKO_Rosiglitzone_12_10_uM_54


title: H3K36me3_heart_E16_EC_cell_288


title: rat_Acetominophen_24_3_mM_140


title: human_HFPO_DA_24_500_uM_A05


title: H3K36me3_heart_E16_EC_cell_293


title: rat_Acetominophen_24_3_mM_139


title: rat_D_Galactosamine_24_0.3_mM_134


title: human_HFPO_DA_24_50_uM_H04


title: mouse_PPARaKO_D_Galactosamine_12_10_mM_51


title: H3K36me3_heart_E16_EC_cell_286


title: human_HFPO_DA_24_50_uM_H02


title: mouse_PPARaKO_D_Galactosamine_12_10_mM_50


title: H3K36me3_heart_E16_EC_cell_287


title: mouse_PPARaKO_Rosiglitzone_12_10_uM_52


title: rat_D_Galactosamine_24_1_mM_137


title: rat_D_Galactosamine_24_0.3_mM_133


title: human_HFPO_DA_24_50_uM_H03


title: human_HFPO_DA_24_500_uM_A07


title: H3K36me3_heart_E16_EC_cell_284


title: H3K36me3_heart_E16_EC_cell_285


title: rat_DMSO_24_0_na_130


title: rat_D_Galactosamine_24_1_mM_135


title: rat_DMSO_24_0_na_129


title: mouse_PPARaKO_Rosiglitzone_12_10_uM_53


title: human_Rosiglitzone_24_10_uM_E07


title: rat_D_Galactosamine_24_0.3_mM_132


title: mouse_PPARaKO_Acetominophen_12_10_mM_46


title: rat_D_Galactosamine_24_0.3_mM_131


title: H3K36me3_heart_E16_EC_cell_283


title: human_Rosiglitzone_24_10_uM_E08


title: mouse_PPARaKO_Acetominophen_12_10_mM_48


title: human_HFPO_DA_24_50_uM_H01


title: human_Rosiglitzone_24_10_uM_E05


title: H3K36me3_heart_E16_EC_cell_282


title: H3K36me3_heart_E16_EC_cell_280


title: mouse_PPARaKO_Acetominophen_12_10_mM_47


title: rat_Deionized_water_24_0_na_126


title: human_GW7647_24_10_uM_E04


title: rat_DMSO_24_0_na_128


title: mouse_PPARaKO_D_Galactosamine_12_10_mM_49


title: mouse_PPARaKO_HFPO_DA_12_5_uM_43


title: human_GW7647_24_10_uM_E03


title: rat_Deionized_water_24_0_na_124


title: human_Rosiglitzone_24_10_uM_E06


title: human_GW7647_24_10_uM_E02


title: mouse_PPARaKO_HFPO_DA_12_5_uM_45


title: H3K36me3_heart_E16_EC_cell_281


title: rat_DMSO_24_0_na_127


title: human_GW7647_24_10_uM_E01


title: mouse_PPARaKO_D_Galactosamine_12_3_mM_42


title: mouse_PPARaKO_HFPO_DA_12_5_uM_44


title: H3K36me3_heart_E16_EC_cell_279


title: H3K36me3_heart_E16_EC_cell_278


title: mouse_PPARaKO_D_Galactosamine_12_3_mM_41


title: rat_Deionized_water_24_0_na_125


title: H3K36me3_heart_E16_EC_cell_276


title: mouse_PPARaKO_D_Galactosamine_12_3_mM_40


title: rat_Deionized_water_24_0_na_123


title: H3K36me3_heart_E16_EC_cell_277


title: human_HFPO_DA_24_5_uM_G03


title: rat_HFPO_DA_24_500_uM_122


title: rat_HFPO_DA_24_500_uM_120


title: human_HFPO_DA_24_5_uM_G04


title: mouse_PPARaKO_Acetominophen_12_3_mM_39


title: rat_HFPO_DA_24_500_uM_121


title: H3K36me3_heart_E16_EC_cell_273


title: H3K36me3_heart_E16_EC_cell_272


title: human_HFPO_DA_24_5_uM_G02


title: rat_HFPO_DA_24_500_uM_119


title: mouse_PPARaKO_Acetominophen_12_3_mM_38


title: rat_HFPO_DA_24_50_uM_118


title: H3K36me3_heart_E16_EC_cell_271


title: mouse_PPARaKO_Rosiglitzone_12_1_uM_36


title: H3K36me3_heart_E16_EC_cell_275


title: mouse_PPARaKO_Acetominophen_12_3_mM_37


title: human_HFPO_DA_24_5_uM_G01


title: human_Rosiglitzone_24_1_uM_D07


title: rat_HFPO_DA_24_50_uM_117


title: mouse_PPARaKO_Rosiglitzone_12_1_uM_35


title: H3K36me3_heart_E16_EC_cell_274


title: human_Rosiglitzone_24_1_uM_D08


title: H3K36me3_heart_E16_EC_cell_269


title: human_Rosiglitzone_24_1_uM_D06


title: rat_HFPO_DA_24_50_uM_115


title: H3K36me3_heart_E16_EC_cell_270


title: mouse_PPARaKO_GW7647_12_1_uM_33


title: H3K36me3_heart_E16_EC_cell_268


title: human_Rosiglitzone_24_1_uM_D05


title: human_GW7647_24_1_uM_D04


title: H3K36me3_heart_E16_EC_cell_267


title: mouse_PPARaKO_GW7647_12_1_uM_32


title: rat_Rosiglitzone_24_10_uM_114


title: rat_HFPO_DA_24_50_uM_116


title: rat_Rosiglitzone_24_10_uM_113


title: human_GW7647_24_1_uM_D03


title: H3K36me3_heart_E16_EC_cell_266


title: rat_Rosiglitzone_24_10_uM_112


title: mouse_PPARaKO_GW7647_12_1_uM_31


title: H3K36me3_heart_E16_EC_cell_265


title: human_GW7647_24_1_uM_D02


title: mouse_PPARaKO_Rosiglitzone_12_1_uM_34


title: mouse_PPARaKO_D_Galactosamine_12_1_mM_30


title: H3K36me3_heart_E16_EC_cell_264


title: mouse_PPARaKO_D_Galactosamine_12_1_mM_29


title: rat_Rosiglitzone_24_10_uM_111


title: human_GW7647_24_1_uM_D01


title: H3K36me3_heart_E16_EC_cell_263


title: rat_GW7647_24_10_uM_110


title: human_Acetominophen_24_1_mM_H08


title: human_Acetominophen_24_1_mM_H07


title: mouse_PPARaKO_Acetominophen_12_1_mM_27


title: rat_GW7647_24_10_uM_109


title: H3K36me3_heart_E16_EC_cell_262


title: mouse_PPARaKO_D_Galactosamine_12_1_mM_28


title: rat_GW7647_24_10_uM_108


title: human_Acetominophen_24_1_mM_H06


title: mouse_PPARaKO_Acetominophen_12_1_mM_26


title: H3K36me3_heart_E16_EC_cell_260


title: rat_GW7647_24_10_uM_107


title: mouse_PPARaKO_Acetominophen_12_1_mM_25


title: human_Acetominophen_24_1_mM_H05


title: H3K36me3_heart_E16_EC_cell_261


title: rat_HFPO_DA_24_5_uM_106


title: H3K36me3_heart_E16_EC_cell_259


title: human_Acetominophen_24_0.3_mM_G08


title: rat_HFPO_DA_24_5_uM_105


title: human_Acetominophen_24_0.3_mM_G06


title: mouse_PPARaKO_D_Galactosamine_12_0.3_mM_23


title: rat_HFPO_DA_24_5_uM_104


title: H3K36me3_heart_E16_EC_cell_257


title: human_Acetominophen_24_0.3_mM_G05


title: mouse_PPARaKO_Acetominophen_12_0.3_mM_21


title: human_Rosiglitzone_24_0.1_uM_C08


title: rat_Rosiglitzone_24_1_uM_102


title: mouse_PPARaKO_Acetominophen_12_0.3_mM_20


title: H3K36me3_heart_E16_EC_cell_256


title: H3K36me3_heart_E16_EC_cell_258


title: human_Acetominophen_24_0.3_mM_G07


title: mouse_PPARaKO_Acetominophen_12_0.3_mM_19


title: H3K36me3_heart_E16_EC_cell_254


title: human_Rosiglitzone_24_0.1_uM_C06


title: H3K36me3_heart_E16_EC_cell_253


title: human_Rosiglitzone_24_0.1_uM_C05


title: H3K36me3_heart_E16_EC_cell_252


title: rat_Rosiglitzone_24_1_uM_100


title: mouse_PPARaKO_D_Galactosamine_12_0.3_mM_22


title: mouse_PPARaKO_Rosiglitzone_12_0.1_uM_17


title: human_Rosiglitzone_24_0.1_uM_C07


title: mouse_PPARaKO_D_Galactosamine_12_0.3_mM_24


title: rat_Rosiglitzone_24_1_uM_99


title: H3K36me3_heart_E16_EC_cell_251


title: human_Rosiglitzone_24_0.01_uM_B08


title: mouse_PPARaKO_Rosiglitzone_12_0.1_uM_16


title: human_Rosiglitzone_24_0.01_uM_B05


title: human_Rosiglitzone_24_0.01_uM_B07


title: rat_GW7647_24_1_uM_95


title: rat_GW7647_24_1_uM_97


title: mouse_PPARaKO_Rosiglitzone_12_0.01_uM_13


title: rat_Acetominophen_24_1_mM_94


title: H3K36me3_heart_E16_EC_cell_255


title: H3K36me3_heart_E16_EC_cell_249


title: human_Rosiglitzone_24_0.01_uM_B06


title: mouse_PPARaKO_Rosiglitzone_12_0.01_uM_15


title: mouse_PPARaKO_Rosiglitzone_12_0.01_uM_14


title: rat_Rosiglitzone_24_1_uM_101


title: H3K36me3_heart_E16_EC_cell_250


title: rat_GW7647_24_1_uM_96


title: rat_Acetominophen_24_1_mM_92


title: H3K36me3_heart_E16_EC_cell_246


title: human_GW7647_24_0.1_uM_C03


title: human_GW7647_24_0.1_uM_C02


title: rat_Acetominophen_24_1_mM_93


title: H3K36me3_heart_E16_EC_cell_248


title: human_GW7647_24_0.1_uM_C04


title: mouse_PPARaKO_GW7647_12_0.1_uM_11


title: rat_GW7647_24_1_uM_98


title: mouse_PPARaKO_GW7647_12_0.1_uM_10


title: mouse_PPARaKO_GW7647_12_0.1_uM_12


title: H3K36me3_heart_E16_EC_cell_245


title: H3K36me3_heart_E16_EC_cell_247


title: rat_Acetominophen_24_1_mM_91


title: H3K36me3_heart_E16_EC_cell_244


title: human_GW7647_24_0.1_uM_C01


title: mouse_PPARaKO_GW7647_12_0.01_uM_9


title: mouse_PPARaKO_GW7647_12_0.01_uM_8


title: rat_HFPO_DA_24_5_uM_103


title: human_GW7647_24_0.01_uM_B04


title: H3K36me3_heart_E16_EC_cell_242


title: human_GW7647_24_0.01_uM_B03


title: human_GW7647_24_0.01_uM_B01


title: mouse_PPARaKO_GW7647_12_0.01_uM_7


title: rat_Acetominophen_24_0.3_mM_88


title: mouse_PPARaKO_HFPO_DA_12_0.1_uM_5


title: mouse_PPARaKO_HFPO_DA_12_0.1_uM_4


title: H3K36me3_heart_E16_EC_cell_243


title: rat_Rosiglitzone_24_0.1_uM_86


title: human_GW7647_24_0.01_uM_B02


title: human_HFPO_DA_24_0.1_uM_F04


title: H3K36me3_heart_E16_EC_cell_239


title: rat_Acetominophen_24_0.3_mM_90


title: mouse_PPARaKO_HFPO_DA_12_0.1_uM_6


title: rat_Rosiglitzone_24_0.1_uM_85


title: rat_Acetominophen_24_0.3_mM_87


title: H3K36me3_heart_E16_EC_cell_241


title: H3K36me3_heart_E16_EC_cell_238


title: human_HFPO_DA_24_0.1_uM_F03


title: rat_Acetominophen_24_0.3_mM_89


title: mouse_PPARaKO_GW7647_12_10_uM_3


title: H3K36me3_heart_E16_EC_cell_240


title: human_HFPO_DA_24_0.1_uM_F02


title: H3K36me3_heart_E16_EC_cell_237


title: rat_Rosiglitzone_24_0.1_uM_84


title: mouse_PPARaKO_GW7647_12_10_uM_2


title: H3K36me3_heart_E16_EC_cell_236


title: rat_Rosiglitzone_24_0.1_uM_83


title: human_HFPO_DA_24_0.1_uM_F01


title: mouse_PPARaKO_GW7647_12_10_uM_1


title: H3K36me3_heart_E16_EC_cell_235


title: rat_Rosiglitzone_24_0.01_uM_81


title: human_DMSO_12_0_na_A03


title: mouse_B6129SF2J_DMSO_72_0_na_220


title: rat_Rosiglitzone_24_0.01_uM_82


title: human_DMSO_12_0_na_A02


title: human_DMSO_12_0_na_A01


title: mouse_B6129SF2J_DMSO_72_0_na_219


title: H3K36me3_heart_E16_EC_cell_233


title: H3K36me3_heart_E16_EC_cell_232


title: rat_Rosiglitzone_24_0.01_uM_79


title: mouse_B6129SF2J_DMSO_72_0_na_218


title: human_Deionized_water_12_0_na_F06


title: human_Deionized_water_12_0_na_F05


title: mouse_B6129SF2J_Deionized_water_72_0_na_217


title: H3K36me3_heart_E16_EC_cell_231


title: rat_GW7647_24_0.1_uM_78


title: mouse_B6129SF2J_Deionized_water_72_0_na_216


title: human_Deionized_water_12_0_na_F04


title: rat_GW7647_24_0.1_uM_77


title: mouse_B6129SF2J_Deionized_water_72_0_na_215


title: rat_GW7647_24_0.1_uM_76


title: human_HFPO_DA_12_500_uM_A06


title: H3K36me3_heart_E16_EC_cell_229


title: H3K36me3_heart_E16_EC_cell_234


title: rat_Rosiglitzone_24_0.01_uM_80


title: rat_GW7647_24_0.1_uM_75


title: human_HFPO_DA_12_500_uM_A04


title: rat_GW7647_24_0.01_uM_74


title: human_HFPO_DA_12_500_uM_A05


title: mouse_B6129SF2J_HFPO_DA_72_500_uM_213


title: mouse_B6129SF2J_HFPO_DA_72_500_uM_214


title: human_HFPO_DA_12_50_uM_H03


title: rat_GW7647_24_0.01_uM_73


title: H3K36me3_heart_E16_EC_cell_226


title: mouse_PPARaKO_Rosiglitzone_12_0.1_uM_18


title: H3K36me3_heart_E16_EC_cell_227


title: mouse_B6129SF2J_HFPO_DA_72_50_uM_211


title: H3K36me3_heart_E16_EC_cell_225


title: human_HFPO_DA_12_50_uM_H02


title: rat_GW7647_24_0.01_uM_72


title: rat_GW7647_24_0.01_uM_71


title: H3K36me3_heart_E16_EC_cell_230


title: human_HFPO_DA_12_50_uM_H01


title: H3K36me3_heart_E16_EC_cell_228


title: H3K36me3_heart_E16_EC_cell_224


title: mouse_B6129SF2J_HFPO_DA_72_50_uM_209


title: rat_HFPO_DA_24_0.1_uM_70


title: human_Rosiglitzone_12_10_uM_E06


title: H3K36me3_heart_E16_EC_cell_223


title: mouse_B6129SF2J_HFPO_DA_72_500_uM_212


title: rat_HFPO_DA_24_0.1_uM_69


title: mouse_B6129SF2J_Rosiglitzone_72_10_uM_208


title: human_Rosiglitzone_12_10_uM_E05


title: H3K36me3_heart_E16_EC_cell_222


title: human_Rosiglitzone_12_10_uM_E04


title: mouse_B6129SF2J_Rosiglitzone_72_10_uM_206


title: H3K36me3_heart_E16_EC_cell_221


title: rat_HFPO_DA_24_0.1_uM_68


title: mouse_B6129SF2J_Rosiglitzone_72_10_uM_207


title: H3K36me3_heart_E16_EC_cell_220


title: rat_HFPO_DA_24_0.1_uM_67


title: human_GW7647_12_10_uM_E03


title: mouse_B6129SF2J_D_Galactosamine_72_10_mM_205


title: mouse_B6129SF2J_HFPO_DA_72_50_uM_210


title: H3K36me3_heart_E16_EC_cell_219


title: human_GW7647_12_10_uM_E02


title: mouse_B6129SF2J_D_Galactosamine_72_10_mM_204


title: H3K36me3_heart_E16_EC_cell_218


title: mouse_B6129SF2J_D_Galactosamine_72_10_mM_203


title: human_GW7647_12_10_uM_E01


title: human_D_Galactosamine_12_10_mM_F09


title: mouse_B6129SF2J_Acetominophen_72_10_mM_202


title: rat_Deionized_water_12_0_na_63


title: H3K36me3_heart_E16_EC_cell_217


title: human_D_Galactosamine_12_10_mM_F08


title: H3K36me3_heart_E16_EC_cell_216


title: rat_Deionized_water_12_0_na_62


title: H3K36me3_heart_E16_EC_cell_215


title: mouse_B6129SF2J_Acetominophen_72_10_mM_201


title: mouse_B6129SF2J_Acetominophen_72_10_mM_200


title: rat_Deionized_water_12_0_na_61


title: rat_DMSO_12_0_na_66


title: H3K36me3_heart_E16_EC_cell_214


title: rat_HFPO_DA_12_500_uM_60


title: rat_DMSO_12_0_na_65


title: H3K36me3_heart_E16_EC_cell_213


title: rat_DMSO_12_0_na_64


title: mouse_B6129SF2J_HFPO_DA_72_5_uM_198


title: human_Acetominophen_12_10_mM_B09


title: mouse_B6129SF2J_HFPO_DA_72_5_uM_199


title: mouse_B6129SF2J_HFPO_DA_72_5_uM_197


title: human_Acetominophen_12_10_mM_B07


title: H3K36me3_heart_E16_EC_cell_212


title: human_HFPO_DA_12_5_uM_G03


title: mouse_B6129SF2J_D_Galactosamine_72_3_mM_196


title: human_D_Galactosamine_12_10_mM_F07


title: rat_HFPO_DA_12_50_uM_57


title: H3K36me3_heart_E16_EC_cell_211


title: H3K36me3_heart_E16_EC_cell_210


title: mouse_B6129SF2J_D_Galactosamine_72_3_mM_195


title: rat_HFPO_DA_12_50_uM_56


title: mouse_B6129SF2J_D_Galactosamine_72_3_mM_194


title: rat_HFPO_DA_12_50_uM_55


title: H3K36me3_heart_E16_EC_cell_209


title: human_Acetominophen_12_10_mM_B08


title: rat_HFPO_DA_12_500_uM_59


title: human_D_Galactosamine_12_3_mM_E09


title: H3K36me3_heart_E16_EC_cell_208


title: mouse_B6129SF2J_Acetominophen_72_3_mM_193


title: rat_HFPO_DA_12_500_uM_58


title: mouse_B6129SF2J_Acetominophen_72_3_mM_192


title: rat_Rosiglitzone_12_10_uM_53


title: human_D_Galactosamine_12_3_mM_E07


title: H3K36me3_heart_E16_EC_cell_207


title: rat_Rosiglitzone_12_10_uM_52


title: human_Acetominophen_12_3_mM_A09


title: human_HFPO_DA_12_5_uM_G02


title: rat_GW7647_12_10_uM_51


title: H3K36me3_heart_E16_EC_cell_205


title: mouse_B6129SF2J_Rosiglitzone_72_1_uM_190


title: human_Acetominophen_12_3_mM_A08


title: human_HFPO_DA_12_5_uM_G01


title: H3K36me3_heart_E16_EC_cell_204


title: mouse_B6129SF2J_Rosiglitzone_72_1_uM_189


title: rat_GW7647_12_10_uM_50


title: human_Acetominophen_12_3_mM_A07


title: rat_GW7647_12_10_uM_49


title: rat_Rosiglitzone_12_10_uM_54


title: mouse_B6129SF2J_Rosiglitzone_72_1_uM_188


title: human_Rosiglitzone_12_1_uM_D06


title: human_D_Galactosamine_12_3_mM_E08


title: rat_D_Galactosamine_12_10_mM_48


title: human_Rosiglitzone_12_1_uM_D05


title: H3K36me3_heart_E16_EC_cell_202


title: mouse_B6129SF2J_GW7647_72_1_uM_187


title: H3K36me3_heart_E16_EC_cell_206


title: mouse_B6129SF2J_Acetominophen_72_3_mM_191


title: H3K36me3_heart_E16_EC_cell_201


title: H3K36me3_heart_E16_EC_cell_200


title: mouse_B6129SF2J_GW7647_72_1_uM_186


title: human_Rosiglitzone_12_1_uM_D04


title: human_GW7647_12_1_uM_D03


title: rat_D_Galactosamine_12_10_mM_46


title: mouse_B6129SF2J_D_Galactosamine_72_1_mM_184


title: rat_Acetominophen_12_10_mM_45


title: human_GW7647_12_1_uM_D02


title: H3K36me3_heart_E16_EC_cell_203


title: mouse_B6129SF2J_D_Galactosamine_72_1_mM_183


title: H3K36me3_heart_E16_EC_cell_199


title: H3K36me3_heart_E16_EC_cell_197


title: H3K36me3_heart_E16_EC_cell_198


title: human_GW7647_12_1_uM_D01


title: rat_Acetominophen_12_10_mM_44


title: mouse_B6129SF2J_D_Galactosamine_72_1_mM_182


title: H3K36me3_heart_E16_EC_cell_196


title: rat_Acetominophen_12_10_mM_43


title: rat_D_Galactosamine_12_10_mM_47


title: mouse_B6129SF2J_Acetominophen_72_1_mM_181


title: mouse_B6129SF2J_GW7647_72_1_uM_185


title: human_D_Galactosamine_12_1_mM_D09


title: H3K36me3_heart_E16_EC_cell_195


title: H3K36me3_heart_E16_EC_cell_194


title: human_D_Galactosamine_12_1_mM_D08


title: human_D_Galactosamine_12_1_mM_D07


title: mouse_B6129SF2J_Acetominophen_72_1_mM_179


title: rat_HFPO_DA_12_5_uM_42


title: rat_HFPO_DA_12_5_uM_41


title: mouse_B6129SF2J_Acetominophen_72_1_mM_180


title: human_Acetominophen_12_1_mM_H06


title: mouse_B6129SF2J_D_Galactosamine_72_0.3_mM_178


title: rat_D_Galactosamine_12_3_mM_39


title: H3K36me3_heart_E16_EC_cell_193


title: human_Acetominophen_12_1_mM_H05


title: H3K36me3_heart_E16_EC_cell_192


title: rat_D_Galactosamine_12_3_mM_38


title: human_Acetominophen_12_1_mM_H04


title: mouse_B6129SF2J_D_Galactosamine_72_0.3_mM_177


title: rat_D_Galactosamine_12_3_mM_37


title: mouse_B6129SF2J_D_Galactosamine_72_0.3_mM_176


title: H3K36me3_heart_E16_EC_cell_191


title: human_D_Galactosamine_12_0.3_mM_C09


title: H3K36me3_heart_E16_EC_cell_190


title: human_D_Galactosamine_12_0.3_mM_C08


title: mouse_B6129SF2J_Acetominophen_72_0.3_mM_175


title: H3K36me3_heart_E16_EC_cell_189


title: rat_HFPO_DA_12_5_uM_40


title: rat_Acetominophen_12_3_mM_36


title: mouse_B6129SF2J_Acetominophen_72_0.3_mM_174


title: human_D_Galactosamine_12_0.3_mM_C07


title: rat_Acetominophen_12_3_mM_35


title: rat_Acetominophen_12_3_mM_34


title: mouse_B6129SF2J_Acetominophen_72_0.3_mM_173


title: H3K36me3_heart_E16_EC_cell_187


title: H3K36me3_heart_E16_EC_cell_188


title: human_Acetominophen_12_0.3_mM_G06


title: rat_Rosiglitzone_12_1_uM_33


title: mouse_B6129SF2J_Rosiglitzone_72_0.1_uM_172


title: human_Acetominophen_12_0.3_mM_G05


title: H3K36me3_heart_E16_EC_cell_186


title: rat_Rosiglitzone_12_1_uM_32


title: mouse_B6129SF2J_Rosiglitzone_72_0.1_uM_171


title: human_Acetominophen_12_0.3_mM_G04


title: H3K36me3_heart_E16_EC_cell_184


title: rat_Rosiglitzone_12_1_uM_31


title: mouse_B6129SF2J_Rosiglitzone_72_0.01_uM_169


title: mouse_B6129SF2J_Rosiglitzone_72_0.1_uM_170


title: human_Rosiglitzone_12_0.1_uM_C06


title: human_Rosiglitzone_12_0.1_uM_C05


title: mouse_B6129SF2J_Rosiglitzone_72_0.01_uM_168


title: rat_GW7647_12_1_uM_30


title: H3K36me3_heart_E16_EC_cell_183


title: H3K36me3_heart_E16_EC_cell_182


title: rat_GW7647_12_1_uM_29


title: rat_GW7647_12_1_uM_28


title: human_Rosiglitzone_12_0.01_uM_B06


title: mouse_B6129SF2J_GW7647_72_0.1_uM_166


title: rat_D_Galactosamine_12_1_mM_27


title: H3K36me3_heart_E16_EC_cell_181


title: human_Rosiglitzone_12_0.1_uM_C04


title: mouse_B6129SF2J_GW7647_72_0.1_uM_165


title: human_Rosiglitzone_12_0.01_uM_B05


title: mouse_B6129SF2J_Rosiglitzone_72_0.01_uM_167


title: human_Rosiglitzone_12_0.01_uM_B04


title: H3K36me3_heart_E16_EC_cell_185


title: H3K36me3_heart_E16_EC_cell_179


title: rat_D_Galactosamine_12_1_mM_26


title: rat_D_Galactosamine_12_1_mM_25


title: H3K36me3_heart_E16_EC_cell_180


title: mouse_B6129SF2J_GW7647_72_0.1_uM_164


title: human_GW7647_12_0.1_uM_C03


title: rat_Acetominophen_12_1_mM_24


title: H3K36me3_heart_E16_EC_cell_178


title: mouse_B6129SF2J_GW7647_72_0.01_uM_163


title: rat_Acetominophen_12_1_mM_23


title: human_GW7647_12_0.1_uM_C02


title: H3K36me3_heart_E16_EC_cell_176


title: mouse_B6129SF2J_GW7647_72_0.01_uM_161


title: human_GW7647_12_0.1_uM_C01


title: H3K36me3_heart_E16_EC_cell_177


title: rat_Acetominophen_12_1_mM_22


title: H3K36me3_heart_E16_EC_cell_175


title: human_GW7647_12_0.01_uM_B03


title: mouse_B6129SF2J_HFPO_DA_72_0.1_uM_160


title: H3K36me3_heart_E16_EC_cell_174


title: mouse_B6129SF2J_HFPO_DA_72_0.1_uM_159


title: human_GW7647_12_0.01_uM_B02


title: rat_D_Galactosamine_12_0.3_mM_20


title: rat_D_Galactosamine_12_0.3_mM_19


title: human_HFPO_DA_12_0.1_uM_F03


title: mouse_B6129SF2J_HFPO_DA_72_0.1_uM_158


title: rat_Acetominophen_12_0.3_mM_18


title: mouse_B6129SF2J_GW7647_72_10_uM_157


title: H3K36me3_heart_E16_EC_cell_172


title: H3K36me3_heart_E16_EC_cell_173


title: H3K36me3_heart_E16_EC_cell_171


title: human_HFPO_DA_12_0.1_uM_F02


title: human_HFPO_DA_12_0.1_uM_F01


title: rat_Acetominophen_12_0.3_mM_17


title: H3K36me3_heart_E16_EC_cell_170


title: mouse_B6129SF2J_GW7647_72_0.01_uM_162


title: mouse_B6129SF2J_GW7647_72_10_uM_155


title: rat_Acetominophen_12_0.3_mM_16


title: rat_Rosiglitzone_12_0.1_uM_15


title: mouse_B6129SF2J_D_Galactosamine_24_10_mM_154


title: H3K36me3_heart_E16_EC_cell_168


title: mouse_B6129SF2J_D_Galactosamine_24_10_mM_153


title: H3K36me3_heart_E16_EC_cell_169


title: human_GW7647_12_0.01_uM_B01


title: rat_Rosiglitzone_12_0.1_uM_14


title: rat_D_Galactosamine_12_0.3_mM_21


title: H3K36me3_heart_E16_EC_cell_167


title: mouse_B6129SF2J_D_Galactosamine_24_10_mM_152


title: H3K36me3_heart_E16_EC_cell_166


title: mouse_B6129SF2J_D_Galactosamine_24_10_mM_151


title: rat_Rosiglitzone_12_0.1_uM_13


title: H3K36me3_heart_E16_EC_cell_165


title: mouse_B6129SF2J_GW7647_72_10_uM_156


title: rat_Rosiglitzone_12_0.01_uM_11


title: mouse_B6129SF2J_Acetominophen_24_10_mM_150


title: H3K36me3_heart_E16_EC_cell_164


title: rat_GW7647_12_0.1_uM_9


title: mouse_B6129SF2J_Acetominophen_24_10_mM_148


title: H3K36me3_heart_E16_EC_cell_163


title: rat_GW7647_12_0.1_uM_8


title: H3K36me3_heart_E16_EC_cell_161


title: mouse_B6129SF2J_D_Galactosamine_24_3_mM_146


title: rat_Rosiglitzone_12_0.01_uM_10


title: H3K36me3_heart_E16_EC_cell_160


title: mouse_B6129SF2J_D_Galactosamine_24_3_mM_144


title: H3K36me3_heart_E16_EC_cell_159


title: mouse_B6129SF2J_D_Galactosamine_24_3_mM_143


title: rat_GW7647_12_0.01_uM_5


title: rat_GW7647_12_0.01_uM_4


title: H3K36me3_heart_E16_EC_cell_158


title: mouse_B6129SF2J_Acetominophen_24_3_mM_142


title: H3K36me3_heart_E16_EC_cell_157


title: rat_Rosiglitzone_12_0.01_uM_12


title: rat_GW7647_12_0.01_uM_6


title: rat_HFPO_DA_12_0.1_uM_3


title: H3K36me3_heart_E16_EC_cell_156


title: mouse_B6129SF2J_Acetominophen_24_3_mM_141


title: mouse_B6129SF2J_Acetominophen_24_10_mM_147


title: H3K36me3_heart_E16_EC_cell_155


title: rat_HFPO_DA_12_0.1_uM_2


title: mouse_B6129SF2J_Acetominophen_24_3_mM_140


title: rat_HFPO_DA_12_0.1_uM_1


title: H3K36me3_heart_E16_EC_cell_153


title: mouse_B6129SF2J_D_Galactosamine_24_1_mM_138


title: H3K36me3_heart_E16_EC_cell_154


title: mouse_B6129SF2J_Acetominophen_24_3_mM_139


title: mouse_B6129SF2J_D_Galactosamine_24_3_mM_145


title: FB, shRNA2 circRTN4(2,3) KD, replicate2

first: Li

last: Yang

address: 131 Dong-An Road

department: Institutes of Biological Sciences

institute: Fudan University

description: FB circRTN4(2,3) shRNA2 KD ribo– RNA-seq replicate2

data_processing:
RNA-seq reads were first processed by trimmomatic (version 0.39, parameters: ILLUMINACLIP: TruSeq3PE-2.fa:2:30:10:8:true LEADING:3 TRAILING:3 SLIDINGWINDOW:4:15 MINLEN:50) to remove low quality bases and adaptor sequences.
Next, trimmed RNA-seq reads were mapped to GRCh38/hg38 human reference genome with the GENCODE (version 35) and NCBI refSeq gene annotations (updated at 08 Apr 2018) by using HISAT2 (version 2.1.0 parameters: --no-softclip --score-min L,-16,0 --mp 7,7 --rfg 0,7 --rdg 0,7 --max-seeds 20 -k 10).
The HISAT2-mapped sam ﬁles were transferred to bam format by samtools (version 1.9).
Gene expression levels were computed with FPKM (Fragments Per Kilobase of transcript per Million mapped reads) by normalized gene counts from featureCounts (version 2.0.1, parameters: -T 12 -t exon -g gene_name -O --fraction).
Assembly: hg38
Supplementary files format and content: tab-delimited text file includes FPKM of each Sample

source_name: Forebrain neuron progenitor cells (Day 26)

extract_protocol:
Total RNAs from cultured cell line or cultured cells with different treatments were extracted with Trizol Reagent (Invitrogen) according to the manufacturer’s protocol. To profile RNA subcellular distribution in FB neuron cells, total/cytoplasmic/nuclear RNAs were processed with the RiboMinus Transcriptome Isolation Kit (Human/Mouse Module, Invitrogen) to deplete ribosomal RNAs for sequencing (ribo– RNA-seq)
The ribo– RNA-seq libraries from  circRTN4(2,3) KD FB neuron cells were prepared using KAPA RNA HyperPrep Kit, followed by size selection using KAPA Pure Beads.

value: H9-derived forebrain neurons

value: circRTN4(2,3) knockdown

value: circRTN4(2,3) shRNA KD


title: FB, shRNA2 circRTN4(2,3) KD, replicate1

description: FB circRTN4(2,3) shRNA2 KD ribo– RNA-seq replicate1

value: Forebrain neuron progenitor cells (Day 26)


title: H3K36me3_heart_E16_EC_cell_152

value: heart

value: Fixed by methanol


title: H3K36me3_heart_E16_EC_cell_162

value: H3K36me3, Active motif, Cat. 61101


title: mouse_B6129SF2J_D_Galactosamine_24_1_mM_137


title: FB, shRNA1 circRTN4(2,3) KD, replicate2

description: FB circRTN4(2,3) shRNA1 KD ribo– RNA-seq replicate2


title: FB, shRNA1 circRTN4(2,3) KD, replicate1

description: FB circRTN4(2,3) shRNA1 KD ribo– RNA-seq replicate1


title: mouse_B6129SF2J_D_Galactosamine_24_1_mM_136


title: FB, scramble, replicate2

description: FB scramble ribo– RNA-seq replicate2

value: WT

value: scramble


title: H3K36me3_heart_E16_EC_cell_151


title: mouse_B6129SF2J_D_Galactosamine_24_1_mM_135


title: FB, scramble, replicate1

description: FB scramble ribo– RNA-seq replicate1


title: H3K36me3_heart_E16_EC_cell_150


title: mouse_B6129SF2J_D_Galactosamine_24_0.3_mM_134


title: H3K36me3_heart_E16_EC_cell_148


title: mouse_B6129SF2J_D_Galactosamine_24_0.3_mM_132


title: H3K36me3_heart_E16_EC_cell_146


title: H3K36me3_heart_E16_EC_cell_147


title: FB, nucleus, replicate1

data_processing:
RNA-seq reads were first processed by trimmomatic (version 0.39, parameters: ILLUMINACLIP: TruSeq3PE-2.fa:2:30:10:8:true LEADING:3 TRAILING:3 SLIDINGWINDOW:4:15 MINLEN:50) to remove low quality bases and adaptor sequences.
Next, for lncRNA and mRNA quantification, trimmed RNA-seq reads were mapped to GRCh38/hg38 human reference genome with the GENCODE (version 35) and NCBI refSeq gene annotations (updated at 08 Apr 2018) by using HISAT2 (version 2.1.0 parameters: --no-softclip --score-min L,-16,0 --mp 7,7 --rfg 0,7 --rdg 0,7 --max-seeds 20 -k 10).
The HISAT2-mapped sam ﬁles were transferred to bam format by samtools (version 1.9).
Gene expression levels were computed with FPKM (Fragments Per Kilobase of transcript per Million mapped reads) by normalized gene counts from featureCounts (version 2.0.1, parameters: -T 12 -t exon -g gene_name -O --fraction).
The circRNA expression levels were computed by FPB (Fragments Per Base) using CIRCexplorer3/CLEAR (version 1.0.0, parameters: clear_quant -1 R1.fq -2 R2.fq -g hg38.fa -i HISAT2_Index -j Bowtie_Index -G annotation.gtf) with the same reference genome and annotation files.
Assembly: hg38
Supplementary files format and content: spreadsheet file includes expression (FPB and FPKM) of circRNAs, mRNAs and lncRNAs in FB

molecule: nuclear RNA

extract_protocol:
Total RNAs from cultured cell line or cultured cells with different treatments were extracted with Trizol Reagent (Invitrogen) according to the manufacturer’s protocol. To profile RNA subcellular distribution in FB neuron cells, total/cytoplasmic/nuclear RNAs were processed with the RiboMinus Transcriptome Isolation Kit (Human/Mouse Module, Invitrogen) to deplete ribosomal RNAs for sequencing (ribo- RNA-seq)
The ribo- RNA-seq libraries from total/cytoplasmic/nuclear RNAs in  FB neuron cells  were prepared using Illumina TruSeq Stranded Total RNA LT Sample Prep Kit, followed by size selection using AmpureXP beads (Agencourt). Size-selected libraries were quantiﬁed with the Agilent Bioanalyzer 2100 and QuBit high-sensitivity dsDNA assay, and then subjected to deep sequencing with Illumina NovaSeq 6000 system at Sequanta Technologies. Raw read qualities were evaluated by FastQC (http://www.bioinformatics.babraham.ac.uk/projects/fastqc/).

value: untreated


title: FB, nucleus, replicate2


title: mouse_B6129SF2J_Acetominophen_24_10_mM_149

value: Acetominophen


title: FB, cytoplasm, replicate2

molecule: cytoplasmic RNA


title: mouse_B6129SF2J_DMSO_24_0_na_130

value: primary hepatocytes

value: DMSO

value: solvent control


title: mouse_B6129SF2J_D_Galactosamine_24_0.3_mM_131


title: FB, cytoplasm, replicate1


title: H3K36me3_heart_E16_EC_cell_145


title: H3K36me3_heart_E16_EC_cell_144


title: mouse_B6129SF2J_DMSO_24_0_na_129


title: mouse_B6129SF2J_DMSO_24_0_na_128


title: H3K36me3_heart_E16_EC_cell_149


title: FB, total cell, replicate1


title: FB, total cell, replicate2


title: H3K36me3_heart_E16_EC_cell_143


title: mouse_B6129SF2J_DMSO_24_0_na_127


title: H3K36me3_heart_E16_EC_cell_141


title: mouse_B6129SF2J_Deionized_water_24_0_na_125


title: mouse_B6129SF2J_D_Galactosamine_24_0.3_mM_133


title: 4-1BB+ CD8+ TIL, patient 5

city: Daejeon

first: Seung Hyuck

last: Jeon

address: 291 Daehak-ro, Yuseong-gu

institute: Korea Advanced Institute of Science and Technology

data_processing:
FASTQ files were mapped to the human genomic DNA reference (GRCh38/hg38) using Hisat2
StringTie was used to quantify gene expression based on the aligned reads.
Assembly: hg38
Supplementary files format and content: tab-delimited text files include FPKM expression for each Sample

source_name: CD8+ tumor-infiltrating T cells

extract_protocol:
Total RNA was extracted from the sorted cells using the SMART-Seq v4 Ultra Low Input RNA Kit (Clontech-Takara).
Libraries were prepared using the SMART-Seq v4 Ultra Low Input RNA Kit (Clontech-Takara).

value: CD8+ tumor-infiltrating T cells

value: primary

value: CD8+ T cell


title: H3K36me3_heart_E16_EC_cell_140

data_processing:
Basecalls performed using CASAVA version 1.8.2.
Reads were de-multiplexed to generate single cell profiles by custom scripts. For spliting single cell, we cut the first 21 bp of the read1 and the first 27 bp of the read2.
Reads were aligned to mouse genome mm10 by bowtie2 (v 2.3.1), with parameter of "--dovetail --very-sensitive-local --no-unal --no-mixed --no-discordant -X 2000".
Reads whose MAPQ >= 30 were determined as uniquely mapping reads. Duplication reads were removed by Picard.
Cells with less than 1,000 non-duplicated were excluded.
Bed files were generated from bam files using bedtools (v2.25.0) bamToBed.
Genome_build: mm10
Supplementary_files_format_and_content: The processed files were bed files. Each single cell bed file contain non-duplicated alignments as is in the bam file.  These files contain single cell genome-wide coverage files after  sorting and uniqing and removing duplicates. Since one cell only contains two copies of each genomic locus for assay, we usually use non-duplicated reads information to reflect peak information in one single cell (PMID: 31471188).

extract_protocol:
Following CoBATCH protocol.
After PCR enrichment using 2X KAPA master mix, products were purified and selected by AMPure XP beads for 200-1000 bp.


title: 4-1BB+ CD8+ TIL, patient 4


title: H3K36me3_heart_E16_EC_cell_139


title: mouse_B6129SF2J_Deionized_water_24_0_na_124


title: 4-1BB- CD8+ TIL, patient 4


title: mouse_B6129SF2J_Deionized_water_24_0_na_123


title: 4-1BB+ CD8+ TIL, patient 3


title: H3K36me3_heart_E16_EC_cell_137


title: mouse_B6129SF2J_HFPO_DA_24_500_uM_122

value: uM


title: H3K36me3_heart_E16_EC_cell_138


title: H3K36me3_heart_E16_EC_cell_136


title: 4-1BB+ CD8+ TIL, patient 2


title: 4-1BB- CD8+ TIL, patient 3


title: mouse_B6129SF2J_HFPO_DA_24_500_uM_121


title: H3K36me3_heart_E16_EC_cell_142


title: mouse_B6129SF2J_HFPO_DA_24_500_uM_120


title: H3K36me3_heart_E16_EC_cell_135


title: mouse_B6129SF2J_HFPO_DA_24_500_uM_119


title: mouse_B6129SF2J_Deionized_water_24_0_na_126


title: 4-1BB- CD8+ TIL, patient 2


title: H3K36me3_heart_E16_EC_cell_134


title: 4-1BB- CD8+ TIL, patient 5


title: H3K36me3_heart_E16_EC_cell_133


title: mouse_B6129SF2J_HFPO_DA_24_50_uM_118


title: 4-1BB+ CD8+ TIL, patient 1


title: mouse_B6129SF2J_HFPO_DA_24_50_uM_117