title: WB, post-COVID-19, control MC1_93

status: Public on Mar 28 2023

city: Lleida

first: David

last: de Gonzalo-Calvo

state: Lleida

address: Rovira Roure 80

institute: IRBLleida

description:
WB, post-COVID-19, control
MC1_93

data_processing:
Raw sequence data in fastq format were processed using a sequential workflow:
(i) data were cleaned of adapters and low-quality sequences using TrimGalore v0.6.6 (https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/ accessed date April 1st, 2021).
(ii) reads were mapped to the reference genome (GRCh38.p12) by the aligner STAR (https://github.com/alexdobin/STAR).
(iii) mapped reads were counted using FeatureCounts (http://subread.sourceforge.net/ accessed date April 1st, 2021).
(iv) global distance analysis and normalization of reads were performed through DESeq2.
(v) differential expression analysis were performed using two different protocols derived from the R package SARTools: DESeq2 y EdgeR.
Assembly: GRCh38.p12
Supplementary files format and content: Tab-delimited text file including normalized counts for each gene per each sample.
Supplementary files format and content: Tab-delimited text file including raw counts for each gene per each sample.

extract_protocol:
Total RNA was extracted from 200 μL of preprocessed whole blood with the Maxwell® RSC simply RNA Blood Kit in combination with the Maxwell® RSC Instruments.
RNA was isolated from 1 μg of total RNA using Illumina´s Ribo-zero plus rRNA depletion kit. The RNA was fragmented into approximately 200 base pair (bp) pieces by using divalent cations under elevated temperature. Reverse transcriptase and random primers were used to generate first strand cDNA from cleaved RNA fragments. DNA polymerase I and RNase H were used to obtain the second strand. Double-stranded cDNA fragments were end-repaired by Klenow DNA polymerase and T4 DNA.  cDNA was phosphorylated by T4 polynucleotide kinase and ligated to Illumina indexing adapters. Adapter-tagged libraries were amplified by using 15 cycles of PCR with DNA polymerase. Validation and quantification were performed using electrophoresis and qPCR. Pools of six indexed libraries were mixed at equimolar ratios to yield a total oligonucleotide mixture concentration of 10 nM.

treatment_protocol: Venous blood samples were collected in Tempus TM blood RNA tubes by venipuncture after a night of fasting and before beginning pulmonary evaluation. Blood samples were stored at -80 °C for future analysis.

value: Whole blood

value: Male

tag: dlco (%_of_predicted)


title: CLP rep2

status: Public on Mar 30 2023

type: SRA

city: Santa Cruz

first: Camilla

last: Forsberg

state: California

address: 1156 High Street

country: USA

institute: Institute for the Biology of Stem Cells, University of California Santa Cruz

library_source: genomic

data_processing:
data was processed using the ENCODE ATAC-seq Pipeline version 1.4.2
Parameters for pipeline were:  atac.multimapping=0, atac.smooth_win=150, atac.enable_idr=true, atac.idr_thresh=0.1
Master peaklist was generated by chromVAR v1.02 and the filterPeaks function using default parameters
Peaks were annotated using annotatePeaks.pl function in HOMER v4.10.2
Genome_build: mm10
Supplementary_files_format_and_content: Annotated Master peak-list output from chromVAR and HOMER

molecule: genomic DNA

organism: Mus musculus

source_name: CLP

growth_protocol: Adult (8-12 weeks old) Wild-type C57/Bl6 mice were sacrificed and cells were harvested from  bone marrow and/or thymus.

extract_protocol:
Cells were collected after sorting into microcentrifuge tubes containing staining media (1xDPBS,1mM EDTA with 5% serum) and centrifuged at 500xg for 5 minutes at 4˚C . Cell pellet was washed with ice-cold 1xDPBS and centrifuged as above. Cells were lysed in (10 mM Tris-HCl, pH 7.4, 10 mM NaCl, 3 mM MgCl2 and 0.1% IGEPAL CA-630) and centrifuged at 500xg for 10 minutes. Samples were suspended 25µL 2xTD Buffer, 2.5µL transposase (Illumina), and 22.5µL nuclease free water and incubated at 37˚C for 30 minutes at 600rpm. Samples were purified using the MinElute Reaction Clean up kit (Qiagen).
Library fragments were amplified using NEBnext PCR mastermix and custom Nextera primers, and size selected using Ampure XP Beads.

treatment_protocol: Bone marrow or thymic cells were stained with flourescent antibodies and sorted by FACS according to established markers.

tag: strain

tag: cell type

value: Common Lymphoid Progenitor

tag: tissue

value: bone marrow


title: WB, post-COVID-19, control MC1_84

country: Spain

description:
WB, post-COVID-19, control
MC1_84

library_source: transcriptomic

molecule: total RNA

organism: Homo sapiens

source_name: Whole blood

tag: age

tag: Sex


title: CMP rep1

source_name: CMP

value: Common Myeloid Progenitor


title: MPP rep1

source_name: MPP

value: Mulitpotent Progenitor


title: WB, post-COVID-19, control MC1_96

description:
WB, post-COVID-19, control
MC1_96


title: WB, post-COVID-19, control MC1_99

description:
WB, post-COVID-19, control
MC1_99


title: CLP rep1


title: WB, post-COVID-19, sequela MC1_88

description:
WB, post-COVID-19, sequela
MC1_88

value: Female


title: WB, post-COVID-19, control MC1_89

description:
WB, post-COVID-19, control
MC1_89


title: WB, post-COVID-19, sequela MC1_86

description:
WB, post-COVID-19, sequela
MC1_86


title: WB, post-COVID-19, control MC1_72

description:
WB, post-COVID-19, control
MC1_72


title: ProT rep1

source_name: ProT

value: T cell Progenitor

value: thymus


title: WB, post-COVID-19, sequela MC1_75

description:
WB, post-COVID-19, sequela
MC1_75


title: WB, post-COVID-19, control MC1_67

description:
WB, post-COVID-19, control
MC1_67


title: WB, post-COVID-19, control MC1_85

description:
WB, post-COVID-19, control
MC1_85


title: WB, post-COVID-19, sequela MC1_81

description:
WB, post-COVID-19, sequela
MC1_81


title: WB, post-COVID-19, control MC1_79

description:
WB, post-COVID-19, control
MC1_79


title: WB, post-COVID-19, sequela MC1_58

description:
WB, post-COVID-19, sequela
MC1_58


title: WB, post-COVID-19, control MC1_57

description:
WB, post-COVID-19, control
MC1_57


title: WB, post-COVID-19, sequela MC1_76

description:
WB, post-COVID-19, sequela
MC1_76


title: WB, post-COVID-19, sequela MC1_56

description:
WB, post-COVID-19, sequela
MC1_56


title: WB, post-COVID-19, control MC1_49

description:
WB, post-COVID-19, control
MC1_49


title: WB, post-COVID-19, control MC1_66

description:
WB, post-COVID-19, control
MC1_66


title: MPP rep2


title: WB, post-COVID-19, control MC1_78

description:
WB, post-COVID-19, control
MC1_78


title: WB, post-COVID-19, control MC1_39

description:
WB, post-COVID-19, control
MC1_39


title: WB, post-COVID-19, control MC1_46

description:
WB, post-COVID-19, control
MC1_46


title: WB, post-COVID-19, control MC1_69

description:
WB, post-COVID-19, control
MC1_69


title: WB, post-COVID-19, control MC1_44

description:
WB, post-COVID-19, control
MC1_44


title: WB, post-COVID-19, control MC1_36

description:
WB, post-COVID-19, control
MC1_36


title: WB, post-COVID-19, sequela MC1_71

description:
WB, post-COVID-19, sequela
MC1_71


title: WB, post-COVID-19, control MC1_34

description:
WB, post-COVID-19, control
MC1_34


title: WB, post-COVID-19, sequela MC1_45

description:
WB, post-COVID-19, sequela
MC1_45


title: WB, post-COVID-19, sequela MC1_38

description:
WB, post-COVID-19, sequela
MC1_38


title: WB, post-COVID-19, control MC1_37

description:
WB, post-COVID-19, control
MC1_37


title: WB, post-COVID-19, control MC1_31

description:
WB, post-COVID-19, control
MC1_31


title: WB, post-COVID-19, control MC1_16

description:
WB, post-COVID-19, control
MC1_16


title: WB, post-COVID-19, sequela MC1_59

description:
WB, post-COVID-19, sequela
MC1_59


title: WB, post-COVID-19, control MC1_32

description:
WB, post-COVID-19, control
MC1_32


title: WB, post-COVID-19, control MC1_30

description:
WB, post-COVID-19, control
MC1_30


title: WB, post-COVID-19, control MC1_26

description:
WB, post-COVID-19, control
MC1_26


title: WB, post-COVID-19, control MC1_12

description:
WB, post-COVID-19, control
MC1_12


title: WB, post-COVID-19, sequela MC1_25

description:
WB, post-COVID-19, sequela
MC1_25


title: WB, post-COVID-19, sequela MC1_15

description:
WB, post-COVID-19, sequela
MC1_15


title: WB, post-COVID-19, sequela MC1_14

description:
WB, post-COVID-19, sequela
MC1_14


title: WB, post-COVID-19, control MC1_10

description:
WB, post-COVID-19, control
MC1_10


title: WB, post-COVID-19, control MC1_4

description:
WB, post-COVID-19, control
MC1_4


title: WB, post-COVID-19, control MC1_1

description:
WB, post-COVID-19, control
MC1_1


title: WB, post-COVID-19, sequela MC1_11

description:
WB, post-COVID-19, sequela
MC1_11


title: 19_D009_atac_lib

status: Public on Mar 14 2023

city: Palo Alto

first: Lattice

last: Data Coordination

state: CA

address: 3165 Porter Drive

department: Genetics

institute: Stanford University

library_source: genomic single cell

data_processing:
raw_matrix_normalized:False; raw_matrix_value_scale:linear; raw_matrix_background_barcodes_included:False
Reads from snRNA-seq were demultiplexed and then aligned to the ‘Ref_cellranger.hg19.premrna’ human reference (from 10x Genomics) using Cell Ranger (version 3.0.2, 10x Genomics). Reads from snATAC-seq were demultiplexed and then aligned to the refdata-cellranger-atac-hg19-1.2.0 human reference (from 10x Genomics) using Cell Ranger (version 1.2.0, 10x Genomics).
Assembly: raw_matrix_assembly:hg19
Supplementary files format and content: raw_matrix_file_format:hdf5

source_name: macula lutea

extract_protocol:
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer’s protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snATAC-seq library was prepared with Chromium Next GEM Single Cell ATAC Library & Gel Bead Kit v1.1 (10x Genomics).
Human retina samples were collected by the Utah Lions Eye Bank within 6 hours postmortem and were confirmed to be free of drusen, atrophy, or other disease pathology. The fovea and macula samples were collected separately, using a 4 mm and 6 mm disposable biopsy punch, respectively, and were flash-frozen in liquid nitrogen. All samples were then stored at −80 °C before nuclei isolation.
Nuclei were isolated by pre-chilled fresh-made RNase-free lysis buffer (10 mM Tris-HCl, 10 mM NaCl, 3 mM MgCl2, 0.02% NP40). The frozen tissue was resuspended and triturated to break the tissue structure in lysis buffer and homogenized with a Wheaton™ Dounce Tissue Grinder.
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer's protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3' Kit v3.1 (10x Genomics). The snATAC-seq library was prepared with Chromium Next GEM Single Cell ATAC Library & Gel Bead Kit v1.1 (10x Genomics). The library was then sequenced on Illumina Novaseq 6000

value: macula lutea

tag: assay

value: 10x scATAC-seq

value: male

tag: ethnicity

value: Hispanic or Latin American

tag: donor id

value: 68 years

tag: library donors living at sample collection

value: FALSE

tag: raw matrix feature keys

value: genomic coordinates

tag: raw matrix value units

value: fragment ends

tag: raw matrix assays

value: snATAC-seq


title: WB, post-COVID-19, control MC1_101

description:
WB, post-COVID-19, control
MC1_101

value: Whole blood

value: Male


title: WB, post-COVID-19, control MC1_8

description:
WB, post-COVID-19, control
MC1_8


title: WB, post-COVID-19, control MC1_47

description:
WB, post-COVID-19, control
MC1_47


title: 19_D006_atac_lib

value: European

value: >89 years


title: 19_D008_atac_lib

value: female

value: 64 years


title: 17D013_NeuNT_lib

library_source: transcriptomic single cell

source_name: peripheral region of retina

extract_protocol:
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer’s protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3’ Kit v3.1 (10x Genomics).
[enrichment protocol] Isolated nuclei were stained with mouse anti-NeuN monoclonal antibody (1:5000, Alexa Flour 488 Conjugate MAB377X, Millipore, Billerica, Massachusetts, United States) in pre-chilled fresh-made wash buffer (1% BSA in PBS, 0.2U/μl RNAse inhibitor) for 30min at 4°C. Stained nuclei were sorted with a FACS Aria II flow sorter (Becton Dickinson, San Jose, CA), (70μm nozzle).   For the NeuNM group, the nuclei with the 5-10% FITC range strongest signal were collected.
Human retina samples were collected by the Utah Lions Eye Bank within 6 hours postmortem and were confirmed to be free of drusen, atrophy, or other disease pathology. The fovea and macula samples were collected separately, using a 4 mm and 6 mm disposable biopsy punch, respectively, and were flash-frozen in liquid nitrogen. All samples were then stored at −80 °C before nuclei isolation.
Nuclei were isolated by pre-chilled fresh-made RNase-free lysis buffer (10 mM Tris-HCl, 10 mM NaCl, 3 mM MgCl2, 0.02% NP40). The frozen tissue was resuspended and triturated to break the tissue structure in lysis buffer and homogenized with a Wheaton™ Dounce Tissue Grinder.
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer's protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3' Kit v3.1 (10x Genomics). The snATAC-seq library was prepared with Chromium Next GEM Single Cell ATAC Library & Gel Bead Kit v1.1 (10x Genomics). The library was then sequenced on Illumina Novaseq 6000

tag: enriched cell type

value: neuron

value: peripheral region of retina

value: 65 years

tag: suspension enrichment factors

value: NeuN

value: gene symbol

tag: raw matrix cellranger assay chemistry

tag: raw matrix genome annotation

value: GENCODE 19

value: UMI

value: snRNA-seq


title: 19_D007_atac_lib

value: macula lutea

value: 10x scATAC-seq

value: male

value: 66 years

value: FALSE

value: genomic coordinates


title: WB, post-COVID-19, sequela MC1_42

description:
WB, post-COVID-19, sequela
MC1_42

value: Whole blood

value: Female

tag: dlco (%_of_predicted)


title: 19_D003_atac_lib

value: European

value: 86 years

value: fragment ends

value: snATAC-seq


title: D021_13_atac_lib


title: D026_13_atac_lib

value: 81 years


title: 19_D005_atac_lib

value: Hispanic or Latin American

value: 53 years


title: D019_13_atac_lib

value: 82 years


title: D018_13_atac_lib

value: female

value: >89 years


title: D017_13_atac_lib

value: macula lutea

value: 10x scATAC-seq

value: 65 years


title: D027_13_atac_lib

value: male

value: 77 years

value: FALSE


title: D028_13_atac_lib

value: 67 years

value: genomic coordinates


title: D005_13_atac_lib

value: European

value: 80 years


title: D001-12_NeuNT_lib

extract_protocol:
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer’s protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3’ Kit v3.1 (10x Genomics).
[enrichment protocol] Isolated nuclei were stained with mouse anti-NeuN monoclonal antibody (1:5000, Alexa Flour 488 Conjugate MAB377X, Millipore, Billerica, Massachusetts, United States) in pre-chilled fresh-made wash buffer (1% BSA in PBS, 0.2U/μl RNAse inhibitor) for 30min at 4°C. Stained nuclei were sorted with a FACS Aria II flow sorter (Becton Dickinson, San Jose, CA), (70μm nozzle).  For the NeuNT group, the nuclei with the strongest 5% FITC signal were collected.
Human retina samples were collected by the Utah Lions Eye Bank within 6 hours postmortem and were confirmed to be free of drusen, atrophy, or other disease pathology. The fovea and macula samples were collected separately, using a 4 mm and 6 mm disposable biopsy punch, respectively, and were flash-frozen in liquid nitrogen. All samples were then stored at −80 °C before nuclei isolation.
Nuclei were isolated by pre-chilled fresh-made RNase-free lysis buffer (10 mM Tris-HCl, 10 mM NaCl, 3 mM MgCl2, 0.02% NP40). The frozen tissue was resuspended and triturated to break the tissue structure in lysis buffer and homogenized with a Wheaton™ Dounce Tissue Grinder.
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer's protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3' Kit v3.1 (10x Genomics). The snATAC-seq library was prepared with Chromium Next GEM Single Cell ATAC Library & Gel Bead Kit v1.1 (10x Genomics). The library was then sequenced on Illumina Novaseq 6000

value: neuron

value: peripheral region of retina

value: 78 years

value: NeuN

value: gene symbol

value: GENCODE 19

value: UMI

value: snRNA-seq


title: D009_13_atac_lib

value: macula lutea

value: 10x scATAC-seq

value: Asian

value: 85 years

value: fragment ends

value: snATAC-seq


title: WB, post-COVID-19, sequela MC1_7

description:
WB, post-COVID-19, sequela
MC1_7

value: Whole blood

value: Female


title: D001-12_NeuNM_lib

value: female

value: European

value: FALSE


title: 19D015_per_lib

extract_protocol:
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer’s protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3’ Kit v3.1 (10x Genomics).
Human retina samples were collected by the Utah Lions Eye Bank within 6 hours postmortem and were confirmed to be free of drusen, atrophy, or other disease pathology. The fovea and macula samples were collected separately, using a 4 mm and 6 mm disposable biopsy punch, respectively, and were flash-frozen in liquid nitrogen. All samples were then stored at −80 °C before nuclei isolation.
Nuclei were isolated by pre-chilled fresh-made RNase-free lysis buffer (10 mM Tris-HCl, 10 mM NaCl, 3 mM MgCl2, 0.02% NP40). The frozen tissue was resuspended and triturated to break the tissue structure in lysis buffer and homogenized with a Wheaton™ Dounce Tissue Grinder.
Single-nuclei cDNA library preparation and sequencing were performed following manufacturer's protocols (https://www.10xgenomics.com). Single-nuclei suspension was loaded on a Chromium controller to obtain single cell GEMS (Gel Beads-In-Emulsions) for the reaction. The snRNA-seq library was prepared with Chromium Next GEM Single Cell 3' Kit v3.1 (10x Genomics). The snATAC-seq library was prepared with Chromium Next GEM Single Cell ATAC Library & Gel Bead Kit v1.1 (10x Genomics). The library was then sequenced on Illumina Novaseq 6000

value: peripheral region of retina

value: male

value: 73 years


title: 19D015_NeuNT_lib

value: neuron

value: NeuN

value: gene symbol

value: GENCODE 19


title: 19D015_mac_lib

source_name: macula lutea proper

value: macula lutea proper

value: UMI

value: snRNA-seq


title: D013_13_atac_lib

value: macula lutea

value: 10x scATAC-seq

value: 69 years

value: genomic coordinates

value: fragment ends


title: 19D014_NeuNT_2_lib

value: European

value: 84 years


title: 19D015_NeuNM_lib

value: peripheral region of retina

value: FALSE


title: 19D014_fovea_lib

source_name: fovea centralis

value: fovea centralis

value: male


title: 19D014_mac_lib


title: WB, post-COVID-19, sequela MC1_65

description:
WB, post-COVID-19, sequela
MC1_65

value: Whole blood

value: Male


title: 19D013_macular_atac_lib

value: female

value: 78 years

value: snATAC-seq


title: 19D014_foveaR_lib

value: gene symbol

value: GENCODE 19

value: UMI

value: snRNA-seq


title: 19D015_fovea_lib

value: 73 years


title: 19D013_fovea_lib


title: 19D013_fovea_atac_lib

value: 10x scATAC-seq

value: genomic coordinates

value: fragment ends


title: 19D013_NeuNT_lib

value: neuron

value: peripheral region of retina

value: European

value: NeuN


title: 19_D019_atac_lib

value: macula lutea

value: 82 years

value: FALSE


title: 19D013_mac_lib

value: macula lutea proper

value: female

value: 78 years


title: 19D013_foveaR_lib

value: fovea centralis

value: gene symbol

value: GENCODE 19


title: 19_D010_atac_lib

value: 88 years

value: snATAC-seq


title: 19_D011_atac_lib

value: 10x scATAC-seq

value: >89 years

value: genomic coordinates


title: 19D016_mac_lib

value: male

value: 83 years

value: UMI

value: snRNA-seq


title: mESC_SIMPLE

status: Public on Feb 28 2023

city: New York

first: Dongsheng

last: Bai

state: NY

address: 101 Avenue of the Americas

institute: New York Genome Center

description: SIMPLE-seq

data_processing:
library strategy: SIMPLE-seq
Cut adapter step: The raw FASTQ files are firstly but the sequencing adapters with cutadapt software
Alignment step: After the cut adapter step, all the FASTQ files are mapped to the reference genome
BAM convert step:The alignment SAM results are converted to sorted BAM files with samtools software
5hmC_CPG_bs100kb_matrix.tar.gz is the cell-to-modification levels matrix for individual cells, each row is a genomic region and each column is a cell, the value in the matrix is the average modification levels of all 5hmCPG in the genomic region. This file is generated by custom script by calculating the average modification levels in each single cell.
5mC_CHG_bs100kb_matrix.tar.gz is the cell-to-modification levels matrix for individual cells, each row is a genomic region and each column is a cell, the value in the matrix is the average modification levels of all 5mCHG in the genomic region. This file is generated by custom script by calculating the average modification levels in each single cell.
5mC_CPG_bs100kb_matrix.tar.gz is the cell-to-modification levels matrix for individual cells, each row is a genomic region and each column is a cell, the value in the matrix is the average modification levels of all 5mCPG in the genomic region. This file is generated by custome script by calculating the average modification levels in each single cell.
The 5hmC_CHG_bs100kb_matrix.tar.gz is the cell-to-modification levels matrix for individual cells, each row is a genomic region and each column is a cell, the value in the matrix is the average modification levels of all 5hmCHG in the genomic region. This file is generated by custom script by calculating the average modification levels in each single cell.
The PBMC_10_states.tar.gz is generated with chromHMM software, by integrating 5mC and 5hmC modification levels in CPG, CHG and CHH contents in 5-kb non-overlapping bins.
wig.tar.gz are wig files showing the 5mC/5hmC modification levels of invididual sites that can be visuallized with genomic browser. This is file is generated by custom script by calculating the average modification levels of individual sites in all cells.
Genome_build: hg39,mm10
Supplementary_files_format_and_content: mESC_5hmC_CHG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5hmCHG sites in mES cells. mESC_5hmC_CPG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5hmCPG sites in mES cells. mESC_5mC_CHG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5mCHG sites in mES cells. mESC_5mC_CPG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5mCPG sites in mES cells. mESC_wig.tar.gz: The genome browser track file showing the modification levels of each cluster of mES cells. PBMC_10_states.tar.gz: The processed cytosine state files generated by chromHMM software. PBMC_5hmC_CHG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5hmCHG sites in PBMC cells. PBMC_5hmC_CPG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5hmCPG sites in PBMC cells. PBMC_5mC_CHG_bs100kb_matrix.tar.gz: The cell-to-modification levels matrix for 5mCHG sites in PBMC cells. PBMC_5mC_CPG_bs100kb_matrix.tar.gz: The cell-to-mod   ification levels matrix for 5mCPG sites in PBMC cells. PBMC_wig.tar.gz: The genome browser track file showing the modification levels of each cluster of PBMC cells.

source_name: mouse ESCs

growth_protocol: Naive mouse Embryonic Stem Cells (mESCs ) were regularly maintained on the pre-gelatinized dishes without feeders, supplemented with two inhibitors (2i): 1 mM PD0325901 (Selleckchem), 3 mM CHIR99021 (Selleckchem) in the presence of 1,000 U/ml leukemia inhibitory factor (LIF, Millipore) and 20% fetal bovine serum (FBS, GIBCO) in Dulbecco’s modified eagle’s medium (DMEM/F-12, GIBCO). Primed mouse Embryonic Stem Cells (mESCs) were cultured with DMEM F12 (GIBCO) with 20% FBS (GIBCO) and 1,000 U/ml LIF (Millipore). Human PBMCs were purchased form AllCells. Cultured cells or PBMCs are harvested and washed with fresh media, then re-suspended in 10mL no-serum media before proceeding to SIMPLE-seq experiments

extract_protocol: The formaldehyde fixed cells are collected and re-suspended in ice cold NIB buffer for nucleosome depilation; the nuclei pellets were tagmentated with identical barcoded assembled Tn5 followed 2 rounds of Ligation-based combinatorial barcoding; nuclei were lysed and gDNA purified with 1X SPRI beads; next, performs Second adaptor tagging and 5hmC transition and hmC-to-T recording; after the primer extension reaction, the dsDNA is subjected into 5mC specific labelling; the final library is amplified by Kapa HiFi uracil plus DNA polymerase and used 1.8X Ampure XP beads to purify the product. The final libraries were sequenced using a MGI-2000 platform (MGI) with the following read lengths: PE 150 + 8 + 150 (Read 1 + Index 1 + Read 2).

value: mouse embryonic stem cells

tag: treatment

value: untreated


title: PBMC_SIMPLE

description: SIMPLE-seq

source_name: human PBMCs

tag: cell type

value: human peripheral blood mononuclear cells


title: RNA-seq, 37°C [rna_wt_37_3]

status: Public on Jan 25 2023

city: St Louis

first: Hani

last: Zaher

state: MO

address: 1 Brookings Drive

department: Biology

institute: Washington University in St. Louis

description:
DESeq2 Differential Expreesion.xlsx
Metagene Analysis.xlsx
Multivariate Analysis.xlsx

data_processing:
Reads were processed using cutadapt 4.1 to remove the linker sequence: CTGTAGGCACCATCAAT with at least 15 nt match. For ribosome profiling reads, only reads with linker were kept while for RNA-seq reads, only reads without linker were kept
rRNAs, tRNAs, and other ncRNAs were removed by first mapping to the SGD R64-1-1 ncRNA file using Hisat2 2.2.1
Reads were mapped to the transcriptome using Salmon 1.9.0 or the genome using STAR 2.7.10b.
Transcriptome mapped reads were analyzed using DESeq2 1.32.0. Genome mapped reads were analyzed using FeatureCounts 2.01 and custom python scripts. Reads were also processed using Samtools 1.16.1 and Bedtools 2.30.0 to determine metagene coverages.
Assembly: SGD R64-1-1
Supplementary files format and content: Excel files of differential expression and metagene statistics.
Supplementary files format and content: Excel file of the multivariate analysis looking at possible correlations between various features and differential expression.
Supplementary files format and content: Excel file of the analysis of differentially expressed genes upregulated by Hsf1 and Msn2/Msn4.

molecule: polyA RNA

organism: Saccharomyces cerevisiae

source_name: whole cell extract

growth_protocol: Grown in YPD at 25°C to OD ~0.5

extract_protocol:
Ribosome protected RNAs were isolated by collecting whole cell extracts, treating with Rnase, centrifugation over sucrose gradients 10-50%, isolating mono- and polysomes, and then extracting RNA using a hot phenol method. Total RNA for RNA-seq was extracted using a hot phenol method.
mRNAs were enriched from total RNA using oligodT beads. Ribosome protected fragments and fragmented mRNAs were dephosphorylated using T4 polynucleotide kinase (NEB). Fragments were then ligated to a short adenylated DNA oligonucleotide – 5’rAppCTGTAGGCACCATCAAT/3ddC/3’ – at their 3’ end using truncated T4 RNA ligase 2 (NEB). Ligated products were purified using denaturing urea PAGE and subjected to reverse transcription using M-MLV (Promega) and RS-1 primer (/5Phos/AGATCGGAAGAGCGTCGTGTAGGGAAAGAGT GTAGATCTCGGTGGTCGC/iSp18/CACTCA/iSp18/TTCAGACGTGTGCTCTTCCG ATCTATTGATGGTGCCTACAG). Following PAGE purification, cDNA products were circularized using CircLigase kit (Epicentre). Optimal amplification cycle number was determined via pilot PCR before PCR amplification with unique barcoded primers.

treatment_protocol: 1 hour at 25°C or 37°C

value: whole cell extract

tag: genotype

value: BY4741 CDC33-HIS3

value: 37degreeC for 1 hour


title: 19D016_atac_lib

tag: tissue

value: macula lutea

value: European

tag: age

value: FALSE

value: fragment ends


title: RNA-seq, 37°C [rna_wt_37_1]


title: RNA-seq, 25°C [rna_wt_25_2]

value: 25degreeC for 1 hour


title: RNA-seq, 37°C [rna_wt_37_2]


title: RNA-seq, 37°C [rna_ts_37_2]


title: RNA-seq, 25°C [rna_wt_25_3]


title: RNA-seq, 37°C [rna_ts_37_3]


title: RNA-seq, 37°C [rna_ts_37_1]


title: RNA-seq, 25°C [rna_ts_25_3]


title: 19D014_fovea_atac_lib

tag: assay

value: 10x scATAC-seq

tag: Sex

value: 84 years

value: snATAC-seq


title: RNA-seq, 25°C [rna_ts_25_2]


title: RNA-seq, 25°C [rna_wt_25_1]


title: RNA-seq, 25°C [rna_ts_25_1]


title: ribosome profiling, 37°C [rpf_ts_37_2]

description:
ribosome protected RNA
DESeq2 Differential Expreesion.xlsx
Metagene Analysis.xlsx
Multivariate Analysis.xlsx

data_processing:
Reads were processed using cutadapt 4.1 to remove the linker sequence: CTGTAGGCACCATCAAT with at least 15 nt match. For ribosome profiling reads, only reads with linker were kept while for RNA-seq reads, only reads without linker were kept
rRNAs, tRNAs, and other ncRNAs were removed by first mapping to the SGD R64-1-1 ncRNA file using Hisat2 2.2.1
Reads were mapped to the transcriptome using Salmon 1.9.0 or the genome using STAR 2.7.10b.
Transcriptome mapped reads were analyzed using DESeq2 1.32.0. Genome mapped reads were analyzed using FeatureCounts 2.01 and custom python scripts. Reads were also processed using Samtools 1.16.1 and Bedtools 2.30.0 to determine metagene coverages.
Assembly: SGD R64-1-1
Supplementary files format and content: Excel files of differential expression and metagene statistics.
Supplementary files format and content: Excel file of the multivariate analysis looking at possible correlations between various features and differential expression.
Supplementary files format and content: Excel file of the analysis of differentially expressed genes upregulated by Hsf1 and Msn2/Msn4.
Library strategy: Ribo-Seq


title: ribosome profiling, 37°C [rpf_ts_37_1]


title: ribosome profiling, 25°C [rpf_ts_25_1]


title: ribosome profiling, 25°C [rpf_ts_25_2]


title: ribosome profiling, 25°C [rpf_wt_25_2]


title: 6_029_01

status: Public on Jan 16 2023

city: Kensington

first: Yike

last: Xie

state: NSW

address: Lowy 2, Cnr High and Botany St

country: Australia

institute: UNSW Sydney

description: viscRNA-Seq 2 (10X Genomics 5’)

data_processing:
The demultiplexing, barcoded processing, gene counting and aggregation were made using the Cell Ranger software after adding DENV genome as additional chromosome (https://support.10xgenomics.com/single-cell-gene-expression/software/pipelines/latest/what-is-cell-ranger)
High quality cells were scored based on the following criteria: fewer than 15% mitochondrial reads; over 400 expressed genes; fewer than 30,000;, and over 1,000 detected UMIs. We excluded genes that were expressed in less than three cells.
Assembly: GRCh38
Supplementary files format and content: Tab-separated values files and mtx files

source_name: Blood

extract_protocol:
PBMCs were isolated using SepMate tubes (Stemcell Technologies) according to the manufacturer’s instructions. Briefly, whole blood was diluted 1:1 with phosphate-buffered saline (PBS) and added to a SepMate tube, which contained 15 ml of Ficoll. Tubes were then centrifuged for 10 minutes at 1,200g, after which the PBMC layer was poured off into a fresh tube and washed with PBS. Tubes were then centrifuged at 250 x g for 10 minutes and resuspended in freezing media. Cryovials containing PBMCs were then placed in a CoolCell at -80 º C for 24 hours prior to being transferred to liquid nitrogen for storage. Each sample containing ~1 ml of cryopreserved PBMCs was quickly thawed in a water bath at 37 ºC in medium containing 10% DMSO. 9 ml of warm medium were added and cells were spun at 300 g for 8 minutes. The supernatant was discarded, and 2 ml of medium were added. The samples were filtered with 35 µm cell strainers to obtain a pure single-cell suspension. The samples were mixed with magnetic microbeads to label cell debris, dead cells, and dying cells (Miltenyi Biotec), and the mix was set on a magnet to elute only living cells. The flow through was spun, the supernatant was removed, and the cell pellet was resuspended in 150 µl cell resining buffer with 0.5% BSA (AutoMACS). To enrich for rare cell populations, the samples were split into 2 aliquots: a 30 µl aliquot was kept intact, and a second aliquot was labeled with anti-CD3- Phycoerythrin (PE) antibody (BioLegend) and mixed with anti-PE magnetic microbeads to reduce the number of T cells. Cell numbers in both aliquots were measured, and the two aliquots were remixed. The samples were then diluted to 1000~1400 cells/µl and processed via viscRNA-seq 2.0.
The master mix containing 10,000-14,000 cells per sample was prepared following the standard 10X Genomics 5' RNA-Seq protocol. A DENV capturing oligo was added to the master mix at a final concentration of 30 nM for capturing the specific DENV serotype identified via RT-qPCR in patient’s sera (DENV1: 5'-AAGCAGTGGTATCAACGCAGAGTACTTTCCCCAGCTTTTCCATGA-3'); DENV3: 5'-AAGCAGTGGTATCAACGCAGAGTACTTTCCCCACGTTTTCCATGA-3'). Samples were loaded into the droplet generator for partitioning single cells into an inverted emulsion. The Next GEM Single Cell 5’ reagent kit (10x Genomics) was used for reverse transcription, cDNA amplification and construction of gene expression libraries. Library quality was assessed using a 2100 Bioanalyzer High Sensitivity DNA kit (Agilent). Sequencing was performed in a paired-end mode with S1 and S4 flow cells (2 X 150 cycles) on a NovaSeq 6000 sequencer (Illumina).

value: PBMCs

value: Blood

value: D


title: ribosome profiling, 37°C [rpf_wt_37_2]


title: ribosome profiling, 37°C [rpf_wt_37_1]


title: 6_023_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 6_028_01

description: viscRNA-Seq 2 (10X Genomics 5’)

value: DWS


title: 5_193_01

description: viscRNA-Seq 2 (10X Genomics 5’)

value: SD


title: 6_020_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 5_130_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 6_001_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 5_010_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 5_154_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 3_047_01

description: viscRNA-Seq 2 (10X Genomics 5’)

value: H


title: 3_037_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 5_030_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 3_074_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 1_144_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 5_044_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 5_089_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 3_012_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 1_140_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 1_113_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: ribosome profiling, 25°C [rpf_wt_25_1]

value: whole cell extract


title: P6_S13_NORMAL

status: Public on Jan 12 2023

city: Shenzhen

first: Yutong

last: He

state: Guangdong

address: GongChangLu 66

country: China

institute: sun yat-sen university

data_processing:
Reads were processed using the Cell Ranger pipeline (3.1.0) with default and recommended parameters.
FASTQs generated from Illumina sequencing output were aligned to the human reference genome GRCh38-3.0.0 were generated for each individual sample by counting unique molecular identifiers (UMIs) and filtering non-cell associated barcodes.
Genome_build: GRCh38
Supplementary_files_format_and_content: gene-barcode matrix containing the barcoded cells and gene expression counts for every sample
Supplementary_files_format_and_content: NORMAL_integrated.rds: integration of all normal samples; AK_integrated.rds: integration of all AK and their patient-matched normal samples; SCC_integrated.rds: integration of all cSCC and their patient-matched normal samples; P2_integrated.rds: integration of P2.

source_name: skin

extract_protocol:
All fresh skin samples were gently washed in RPMI 1640 after removing crust, subcutaneous fat and necrotic tissue with surgical scissors and cutting the tissue into small pieces of 2–4 mm in a sterile tissue-culture dish. For tumor samples digestion was performed using tumor dissociation kit for human (130-095-929, MACS Miltenyi Biotec), mechanical dissociation using gentleMacs Dissociator running the gentleMACS program h_tumor_01. In order to capture enough keratinocytes in AK samples for subsequent research, we separate the epidermal tissue from the dermis and then dissociated to single-cell suspensions by combining mechanical dissociation with enzymatic degradation of the extracellular adhesion proteins using Epidermis Dissociation Kit for Human (130-103-464, MACS Miltenyi Biotec). The dissociated cell suspension was strained with a 40μm filter (BD Falcon), and treated with Red Blood Cell Lysis Solution (130-103-183, MACS Miltenyi Biotec) and dead cell removal using the Dead Cell Removal Kit (130-090-101, MACS Miltenyi Biotec) to confirm cell viability >85% with trypan blue staining (Invitrogen). All samples were processed as per manufacturer’s instructions. Sorted cells were centrifuged and resuspended in PBS + 0.04% BSA (Gibco) to a final cell concentration of 700-1200 cells/μL as determined by hemacytometer.
Chromium Single Cell 3' v3 (10X Genomics) library preparation kit according to the manufacturer’s protocol

value: skin

tag: disease state

value: normal


title: 1_019_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: P5_S11_NORMAL


title: P6_S12_cSCC

value: cSCC II


title: P5_S10_cSCC_ATAC

value: cSCC III


title: 1_002_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: 1_075_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: P5_S10_cSCC


title: P4_S9_NORMAL


title: 6_025_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: P2_S5_NORMAL


title: P2_S4_SCCIS

value: SCCIS


title: 5_041_01

description: viscRNA-Seq 2 (10X Genomics 5’)


title: P3_S7_NORMAL


title: P2_S3_AK

value: AK II


title: P3_S6_AK

value: AK I


title: HCT17HEX, scATACseq

status: Public on Jan 09 2023

city: Huntsville

first: Lindsay

last: Rizzardi

state: AL

address: 601 Genome Way

institute: HudsonAlpha Institute for Biotechnology

description: 10x Genomics

data_processing:
The demultiplexing, barcoded processing, gene counting and aggregation were made using the Cell Ranger Arc software v2.0.0 (https://support.10xgenomics.com/single-cell-multiome-atac-gex/software/pipelines/latest/what-is-cell-ranger-arc)
Sample demultiplexing was done with cellSNP and vireo (https://cellsnp-lite.readthedocs.io/en/latest/ , https://vireosnp.readthedocs.io/en/latest/) to get a list of barcodes assigned to each sample. Cellranger-arc bams were split on list of barcodes for each sample then converted back to fastqs with cellranger bamtofastq.
Processed files include paired scRNAseq and scATACseq counts from the same cells
Assembly: hg38
Supplementary files format and content: 10x HDF5 RNA+ATAC counts matrix; table of cell barcodes by seurat meta data

extract_protocol:
Approximately 50-100 mg of frozen tissue per sample was homogenized in 4 mL of nuclei extraction buffer [0.32 M sucrose, 10 mM Tris pH 7.4, 5 mM CaCl2, 3 mM Mg acetate, 1 mM DTT, 0.1 mM EDTA, 0.1% Triton X-100, 0.2U/uL Protector RNAse inhibitor (Sigma cat. 3335399001)] by douncing 30 times in a 40 mL dounce homogenizer. Filter through 70 um filter and spin at 500xg, 5 min at 4°C in a swinging bucket centrifuge. Resuspend nuclei in 500 uL nuclei extraction buffer and layer over 750 uL sucrose solution (1.8 M sucrose, 10 mM Tris pH 7.4, 3 mM Mg acetate, 1 mM DTT) in a 1.5 mL tube. The samples were then centrifuged at >16,000 x g for 30 min at 4°C. After centrifugation, the supernatant was removed by aspiration and the nuclear pellet was resuspended in 125 uL PBS with 1% BSA and centrifuged 5 min at 500 x g at 4°C in a swinging bucket centrifuge. Permeabilization was performed according to 10X Genomics protocol CG000375 Rev B:  nuclei were resuspended in 100 uL lysis buffer (10 mM Tris-HCl pH 7.4,10 mM NaCl, 3 mM MgCl2, 1% BSA, 0.01% Tween-20, 0.01% NP-40, 0.001% digitonin, 1 mM DTT, 1 U/uL Protector RNase inhibitor) and incubated 2 min on ice. Nuclei were washed once and resuspended in 30 uL of 1X nuclei buffer with 1 mM DTT and 0.5 U/uL of Protector RNAse inhibitor. Nuclei quality and concentrations were determined using the Countess.
Library was performed according to the manufacter’s instructions (single cell multiome protocol CG000338 Rev E, 10x Genomics).

value: control

value: M


title: HCTZZT, scRNAseq

description: 10x Genomics

data_processing:
The demultiplexing, barcoded processing, gene counting and aggregation were made using the Cell Ranger Arc software v2.0.0 (https://support.10xgenomics.com/single-cell-multiome-atac-gex/software/pipelines/latest/what-is-cell-ranger-arc)
Sample demultiplexing was done with cellSNP and vireo (https://cellsnp-lite.readthedocs.io/en/latest/ , https://vireosnp.readthedocs.io/en/latest/) to get a list of barcodes assigned to each sample. Cellranger-arc bams were split on list of barcodes for each sample then converted back to fastqs with cellranger bamtofastq.
Processed files include paired scRNAseq and scATACseq counts from the same cells
Assembly: hg38
Supplementary files format and content: 10x HDF5 RNA+ATAC counts matrix

value: F


title: HCTZZT, scATACseq

description: 10x Genomics


title: HCT17HEX, scRNAseq

description: 10x Genomics


title: CSF_Healthy_H7

status: Public on Dec 12 2022

city: Chicago

last: Gate

state: IL

address: 303 E Chicago Ave, Chicago, IL 60611

department: Neurology

institute: Northwestern University

data_processing:
Illumina RTA3 method for base-calling
10xGenomics cellranger pipeline for alignment and filtering (trimming 5' TSO sequence and 3' polyA tail, alignment with STAR, UMI counting, EmptyDrops method for empty droplet removal)
SoupX background contamination removal (CD14, CD68, CD16, and MS4A7 were used to estimate contamination fraction and counts were adjusted using SoupX::adjustCounts function)
DoubletFinder doublet removal (doublet formation rate of 1% based on 10xGenomics multiplet rate estimation, using 12 PCs and pN = 0.25)
Seurat filtering and normalization (filter out cells with >10% mitochondrial reads, retain cells with at least 200 mapped features, retain features with at least 3 mapped cells, counts were then normalized using Seurat's LogNormalize method)
Assembly: hg38
Supplementary files format and content: matrix table of raw gene counts for each gene and cell barcode
Supplementary files format and content: matrix table log-normalized expression values for each gene and cell barcode

source_name: Cerebrospinal fluid

extract_protocol:
CSF was pelleted, frozen, and resuspended in PBS with 1% BSA before being sorted with Sytox blue live/dead dye
Chromium Next GEM Single Cell 5' v2 with immune profiling
scRNAseq + scV(D)J

value: Female

tag: diagnosis

value: Healthy


title: CSF_Healthy_H2


title: CSF_Healthy_H3


title: P1_S1_AK


title: CSF_Healthy_H8

value: Male


title: CSF_Healthy_H4


title: CSF_Healthy_G5


title: CSF_Healthy_H6


title: CSF_Healthy_G4


title: CSF_Healthy_G8


title: CSF_Healthy_G3


title: CSF_Healthy_G7


title: CSF_MCI/AD_H1

value: MCI/AD


title: P4_S8_cSCC

value: cSCC I


title: CSF_Healthy_G2


title: CSF_MCI/AD_G6


title: CSF_Healthy_F8


title: CSF_Healthy_G1


title: CSF_Healthy_F7


title: P1_S2_NORMAL


title: CSF_Healthy_F6


title: CSF_Healthy_F4


title: CSF_Healthy_F3


title: CSF_Healthy_F2


title: CSF_Healthy_F1


title: CSF_Healthy_E8


title: CSF_MCI/AD_E7


title: CSF_Healthy_E3


title: CSF_MCI/AD_E4


title: CSF_MCI/AD_E5


title: CSF_Healthy_E2


title: CSF_Healthy_H5


title: CSF_Healthy_D8


title: CSF_Healthy_D6


title: CSF_MCI/AD_E1


title: CSF_Healthy_C8


title: CSF_Healthy_D4


title: CSF_MCI/AD_D2


title: CSF_Healthy_D5


title: CSF_MCI/AD_D3


title: CSF_Healthy_C4


title: CSF_Healthy_D1


title: CSF_Healthy_C1


title: CSF_Healthy_C6


title: CSF_Healthy_C3


title: CSF_Healthy_C2


title: CSF_Healthy_B8


title: CSF_MCI/AD_B6


title: CSF_MCI/AD_B4


title: CSF_MCI/AD_B7


title: CSF_MCI/AD_B1


title: CSF_Healthy_B3


title: CSF_Healthy_B2


title: CSF_Healthy_A8


title: CSF_Healthy_A4


title: CSF_Healthy_A2


title: CSF_Healthy_A5


title: CSF_Healthy_A1


title: FosB null LEC six hour sample 3

status: Public on Nov 16 2022

city: Newark

first: Melinda

middle: K.

last: Duncan

state: DE

address: 327 Wolf Hall

department: Biological Sciences

institute: University of Delaware

description:
FB_6H_3
WDS_FB_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_FB_vs_WT_Differential_Expression.xlsx

data_processing:
Aggregate individual lane files (4 per sample) into a single file for each sample
Remove reads aligning to the Rn45s prespliced transcript using HISAT2
Aligned non Ribosomal reads using HISAT2 ( -fr --rna-strandedness RF, default otherwise)
Quantified genes using htseq-count -m union
Normalized counts using TMM (in edgeR)
Tested for differential expression using edgeR's Exact test
Assembly: GRCm39 / Ensembl v104
Supplementary files format and content: Gene level counts and Differential Expression analysis results in an excel spreadsheet
Supplementary files format and content: Individual count files for each sample

organism: Mus

source_name: lens capsule

extract_protocol:
RNeasy Micro Kit (50) Cat. No. / ID: 74004
Takara SMARTer Stranded Pico v2
Paired end, ribodepletion

value: lens capsule

tag: strain

value: lens epithelial cells (LEC)

value: FosB Lens cKO

tag: time point

value: 6 hr


title: FosB null LEC zero hour sample 2

description:
FB_0H_2
WDS_FB_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_FB_vs_WT_Differential_Expression.xlsx

value: 0 hr


title: CSF_MCI/AD_C5


title: FosB null LEC six hour sample 2

description:
FB_6H_2
WDS_FB_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_FB_vs_WT_Differential_Expression.xlsx


title: FosB null LEC zero hour sample 1

description:
FB_0H_1
WDS_FB_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_FB_vs_WT_Differential_Expression.xlsx


title: FosB null LEC six hour sample 1

description:
FB_6H_1
WDS_FB_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_FB_vs_WT_Differential_Expression.xlsx


title: Egr1 null LEC six hour sample 1

description:
E1_6H_1
WDS_E1_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_E1_vs_WT_Differential_Expression.xlsx

value: Egr1 KO


title: Egr1 null LEC six hour sample 3

description:
E1_6H_3
WDS_E1_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_E1_vs_WT_Differential_Expression.xlsx


title: FosB null LEC zero hour sample 3

description:
FB_0H_3
WDS_FB_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_FB_vs_WT_Differential_Expression.xlsx


title: Egr1 null LEC zero hour sample 2

description:
E1_0H_2
WDS_E1_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_E1_vs_WT_Differential_Expression.xlsx


title: Egr1 null LEC zero hour sample 3

description:
E1_0H_3
WDS_E1_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_E1_vs_WT_Differential_Expression.xlsx


title: Wild-type LEC six hour sample 3

description:
WT_6H_3
WDS_WT_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_E1_vs_WT_Differential_Expression.xlsx
WDS_6H_FB_vs_WT_Differential_Expression.xlsx

value: wildtype


title: Wild-type LEC six hour sample 2

description:
WT_6H_2
WDS_WT_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_E1_vs_WT_Differential_Expression.xlsx
WDS_6H_FB_vs_WT_Differential_Expression.xlsx


title: Wild-type LEC six hour sample 1

description:
WT_6H_1
WDS_WT_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_E1_vs_WT_Differential_Expression.xlsx
WDS_6H_FB_vs_WT_Differential_Expression.xlsx


title: Wild-type LEC zero hour sample 3

description:
WT_0H_3
WDS_WT_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_E1_vs_WT_Differential_Expression.xlsx
WDS_0H_FB_vs_WT_Differential_Expression.xlsx


title: Wild-type LEC zero hour sample 2

description:
WT_0H_2
WDS_WT_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_E1_vs_WT_Differential_Expression.xlsx
WDS_0H_FB_vs_WT_Differential_Expression.xlsx


title: Egr1 null LEC six hour sample 2

description:
E1_6H_2
WDS_E1_6H_vs_0H_Differential_Expression.xlsx
WDS_6H_E1_vs_WT_Differential_Expression.xlsx


title: CSF_Healthy_B5


title: Wild-type LEC zero hour sample 1

description:
WT_0H_1
WDS_WT_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_E1_vs_WT_Differential_Expression.xlsx
WDS_0H_FB_vs_WT_Differential_Expression.xlsx


title: CSF_Healthy_A7


title: Wildtype LEC six hour sample 2

data_processing:
Aligned reads using HISAT2 ( -fr --rna-strandedness RF, default otherwise)
Quantified genes using htseq-count -m union
Normalized counts using TMM (in edgeR)
Tested for differential expression using edgeR's Quasi-Likelihood F-Test
Assembly: GRCm38.p6 / Ensembl v100
Supplementary files format and content: Differential Expression analysis results in an excel spreadsheet
Supplementary files format and content: AVG RPKM

extract_protocol:
RNeasy Mini Kit (50) from Qiagen (Cat No./ID: 74104).
Takara SMARTer Stranded Pico v2
Paired end, ribodepletion

value: 2 months


title: CSF_MCI/AD_A6


title: Wildtype LEC six hour sample 1


title: Wildtype LEC zero hour sample 3


title: Wildtype LEC zero hour sample 1


title: Wildtype LEC zero hour sample 2


title: VRP MSN09-04R-CM Rep 3 (Conv)

status: Public on Nov 14 2022

first: Ravi

last: Iyengar

address: 1425 Madison Avenue, Room 12-70C

department: Pharmacological Sciences

institute: Icahn School of Medicine at Mount Sinai

data_processing:
Preparing required software packages (README.pdf for details)
Preparing required input data files (README.pdf for details)
Aligning random-primed mRNA sequence reads (README.pdf for details)
Mapping aligned sequence reads to reference genes (README.pdf for details)
Identifying differentially expressed genes under drug treatments (README.pdf for details)
Assembly: Reference-Library.tar.gz: a compressed file containing the UCSC human genome referece library (version hg38)
Supplementary files format and content: Conv-RNAseq-Experiment-Design.tsv.gz: a compressed file containing the experiment design table of all the samples from the conventional dataset to be used by the DEG-comparison pipeline
Supplementary files format and content: Conv-RNAseq-Read-Counts.tsv.gz: a compressed file containing the read counts table of the uniquely aligned sequence fragments for the conventional dataset
Supplementary files format and content: Conv-RNAseq-Configs.tar.gz: a compressed file containing the configuration of the DEG-comparison pipeline file for the conventional dataset
Supplementary files format and content: Conv-RNAseq-Params.tar.gz: a compressed file containing the input parameter files of the DEG-comparison pipeline file for the conventional dataset
Supplementary files format and content: Conv-DEG-Calc-FDR-0.1.tar.gz: a compressed file containing a set of statistical comparison results of differentially expressed genes at each drug-treated condition with the file names in a form of Human-[Cell Line]-Hour-48-Plate-[Plate Number]-Calc.CTRL-[Drug Name].tsv for the conventional dataset
Supplementary files format and content: Program-Source-Codes.tar.gz: a compressed file containing the source codes for sequence alignment, feature counts, and differential comparison.
Supplementary files format and content: README.pdf.gz: a compressed PDF file containing detailed instructions for running the pipeline

source_name: induced pluripotent stem cell

growth_protocol: Cultured under growth conditions with E8 media and differentiated for 20 days with differentiation media,start Lactate Metabolic Selection for one week,Plate 240k cells into one well of 24-well plate and growth for one week for drug treatment. (see DToxS SOP CE)

extract_protocol:
Total RNA was isolated using Trizol (see DToxS SOP A – 1.0: Total RNA Isolation)
Library was prepared using 300 ng of total RNA enriched for mRNA using polyA beads and the TruSeq RNA Library Prep Kit (Illumina, Cat: RS-122-2001) per manufacturer’s instructions (See DToxS SOP A - 6.0: High-throughput mRNA Seq Library Construction for 3' Digital Gene Expression (DGE)

treatment_protocol: Fully confluent and differentiated cells were treated with drugs or vehicle (DMSO) for 48 hours (see DToxS SOP CE – 4.0: Drug Treatment and Cell Lysis)

value: skin

value: cardiac myocytes

tag: cell line

tag: treatment time (hrs)

tag: treatment condition

value: VRP

tag: drug name

value: Verapamil

tag: concentration

tag: well

tag: investigative unit

tag: sample id

tag: rna amount (ng)

tag: rin

tag: rna conc (ng/ul)

tag: rna volume (ul)

tag: h2o volume (ul)


title: VRP MSN09-04R-CM Rep 2 (Conv)

tag: tissue

tag: cell type


title: Egr1 null LEC zero hour sample 1

description:
E1_0H_1
WDS_E1_6H_vs_0H_Differential_Expression.xlsx
WDS_0H_E1_vs_WT_Differential_Expression.xlsx

tag: strain

tag: genotype


title: VRP MSN09-04R-CM Rep 1 (Conv)

tag: cell line


title: VRP MSN09-04R-CM Rep 4 (Conv)

tag: treatment time (hrs)


title: VRP MSN08-13R-CM Rep 4 (Conv)

tag: treatment condition


title: VRP MSN08-13R-CM Rep 1 (Conv)

tag: drug name


title: VRP MSN06-07R-CM Rep 3 (Conv)

tag: concentration


title: VRP MSN08-13R-CM Rep 2 (Conv)

tag: well


title: VRP MSN06-07R-CM Rep 2 (Conv)

tag: investigative unit


title: VRP MSN05-01R-CM Rep 4 (Conv)

tag: sample id


title: VRP MSN05-01R-CM Rep 3 (Conv)

tag: rna amount (ng)


title: VRP MSN05-01R-CM Rep 2 (Conv)

tag: rin


title: VRP MSN05-01R-CM Rep 1 (Conv)

tag: rna conc (ng/ul)


title: Wildtype LEC six hour sample 3

tag: age

tag: time point


title: VRP MSN02-04R-CM Rep 1 (Conv)

tag: tissue

tag: rna volume (ul)

tag: h2o volume (ul)


title: VRP MSN01-03R-CM Rep 2 (Conv)

tag: cell type


title: VRP MSN01-03R-CM Rep 4 (Conv)

tag: cell line


title: VRP MSN01-03R-CM Rep 3 (Conv)

tag: treatment time (hrs)


title: VRP MSN01-03R-CM Rep 1 (Conv)

tag: treatment condition


title: VEM MSN09-04R-CM Rep 3 (Conv)

value: VEM

tag: drug name

value: Vemurafenib


title: VEM MSN09-04R-CM Rep 4 (Conv)

tag: concentration


title: VEM MSN08-13R-CM Rep 4 (Conv)

tag: well


title: VEM MSN09-04R-CM Rep 1 (Conv)

tag: investigative unit


title: VEM MSN08-13R-CM Rep 3 (Conv)

tag: sample id


title: VEM MSN09-04R-CM Rep 2 (Conv)

tag: rna amount (ng)


title: VEM MSN08-13R-CM Rep 2 (Conv)

tag: rin


title: VRP MSN02-04R-CM Rep 2 (Conv)

tag: rna conc (ng/ul)


title: VRP MSN08-13R-CM Rep 3 (Conv)


title: VEM MSN06-07R-CM Rep 3 (Conv)


title: VEM MSN06-07R-CM Rep 1 (Conv)


title: VEM MSN05-01R-CM Rep 4 (Conv)


title: VEM MSN06-07R-CM Rep 2 (Conv)


title: VRP MSN06-07R-CM Rep 1 (Conv)


title: VEM MSN05-01R-CM Rep 3 (Conv)


title: VEM MSN05-01R-CM Rep 2 (Conv)


title: VEM MSN01-03R-CM Rep 4 (Conv)


title: VEM MSN05-01R-CM Rep 1 (Conv)


title: VEM MSN01-03R-CM Rep 1 (Conv)


title: VAN MSN09-04R-CM Rep 4 (Conv)

value: VAN

value: Vandetanib


title: VAN MSN09-04R-CM Rep 2 (Conv)


title: VAN MSN08-13R-CM Rep 4 (Conv)


title: VEM MSN01-03R-CM Rep 3 (Conv)


title: VAN MSN09-04R-CM Rep 1 (Conv)


title: VAN MSN09-04R-CM Rep 3 (Conv)


title: VAN MSN08-13R-CM Rep 1 (Conv)


title: VAN MSN08-13R-CM Rep 3 (Conv)


title: VEM MSN08-13R-CM Rep 1 (Conv)


title: VAN MSN05-01R-CM Rep 4 (Conv)


title: VAN MSN06-07R-CM Rep 2 (Conv)


title: VEM MSN06-07R-CM Rep 4 (Conv)


title: VAN MSN06-07R-CM Rep 1 (Conv)


title: VAN MSN05-01R-CM Rep 3 (Conv)


title: VAN MSN08-13R-CM Rep 2 (Conv)


title: VAN MSN05-01R-CM Rep 2 (Conv)


title: VAN MSN05-01R-CM Rep 1 (Conv)


title: VAN MSN02-04R-CM Rep 1 (Conv)


title: VAN MSN01-03R-CM Rep 2 (Conv)


title: TRS MSN09-04R-CM Rep 4 (Conv)

value: TRS

value: Trastuzumab


title: VAN MSN01-03R-CM Rep 1 (Conv)


title: VAN MSN02-04R-CM Rep 2 (Conv)


title: TRS MSN09-04R-CM Rep 2 (Conv)


title: TRS MSN09-04R-CM Rep 3 (Conv)


title: VAN MSN01-03R-CM Rep 3 (Conv)


title: VAN MSN01-03R-CM Rep 4 (Conv)


title: VEM MSN01-03R-CM Rep 2 (Conv)


title: TRS MSN06-07R-CM Rep 2 (Conv)


title: TRS MSN05-01R-CM Rep 3 (Conv)


title: TRS MSN05-01R-CM Rep 4 (Conv)


title: TRS MSN06-07R-CM Rep 3 (Conv)


title: TRS MSN08-13R-CM Rep 2 (Conv)


title: TRS MSN06-07R-CM Rep 1 (Conv)


title: TRS MSN08-13R-CM Rep 1 (Conv)


title: TRS MSN02-04R-CM Rep 2 (Conv)


title: TRS MSN01-03R-CM Rep 4 (Conv)


title: TRS MSN02-04R-CM Rep 1 (Conv)


title: TRA MSN09-04R-CM Rep 4 (Conv)

value: TRA

value: Trametinib


title: TRS MSN01-03R-CM Rep 1 (Conv)


title: TRS MSN05-01R-CM Rep 1 (Conv)


title: TRS MSN05-01R-CM Rep 2 (Conv)


title: TRS MSN01-03R-CM Rep 3 (Conv)


title: TRA MSN08-13R-CM Rep 4 (Conv)


title: TRA MSN09-04R-CM Rep 3 (Conv)


title: TRA MSN09-04R-CM Rep 1 (Conv)


title: TRS MSN09-04R-CM Rep 1 (Conv)


title: TRS MSN08-13R-CM Rep 3 (Conv)


title: TRA MSN08-13R-CM Rep 1 (Conv)


title: TRA MSN06-07R-CM Rep 3 (Conv)


title: TRA MSN05-01R-CM Rep 4 (Conv)


title: TRA MSN06-07R-CM Rep 1 (Conv)


title: TRA MSN08-13R-CM Rep 3 (Conv)


title: TRA MSN05-01R-CM Rep 2 (Conv)


title: TRA MSN05-01R-CM Rep 3 (Conv)


title: TRA MSN01-03R-CM Rep 1 (Conv)


title: TRA MSN05-01R-CM Rep 1 (Conv)


title: TRA MSN01-03R-CM Rep 2 (Conv)


title: TRA MSN01-03R-CM Rep 4 (Conv)


title: TOF MSN09-04R-CM Rep 4 (Conv)

value: TOF

value: Tofacitinib


title: TRA MSN01-03R-CM Rep 3 (Conv)


title: TRS MSN01-03R-CM Rep 2 (Conv)


title: TOF MSN09-04R-CM Rep 1 (Conv)


title: TRA MSN09-04R-CM Rep 2 (Conv)


title: TOF MSN08-13R-CM Rep 2 (Conv)


title: TOF MSN09-04R-CM Rep 2 (Conv)


title: TOF MSN08-13R-CM Rep 3 (Conv)


title: TOF MSN09-04R-CM Rep 3 (Conv)


title: TRA MSN08-13R-CM Rep 2 (Conv)


title: TOF MSN06-07R-CM Rep 2 (Conv)


title: TOF MSN06-07R-CM Rep 1 (Conv)


title: TOF MSN05-01R-CM Rep 3 (Conv)


title: TOF MSN05-01R-CM Rep 4 (Conv)


title: TOF MSN05-01R-CM Rep 1 (Conv)


title: TRA MSN06-07R-CM Rep 2 (Conv)


title: TOF MSN01-03R-CM Rep 4 (Conv)


title: TOF MSN01-03R-CM Rep 3 (Conv)


title: TOF MSN05-01R-CM Rep 2 (Conv)


title: TOF MSN01-03R-CM Rep 1 (Conv)


title: TOF MSN01-03R-CM Rep 2 (Conv)


title: TNF MSN09-04R-CM Rep 3 (Conv)

value: TNF

value: TNF-alpha


title: TNF MSN09-04R-CM Rep 1 (Conv)


title: TOF MSN08-13R-CM Rep 4 (Conv)


title: TOF MSN08-13R-CM Rep 1 (Conv)


title: TNF MSN09-04R-CM Rep 2 (Conv)


title: TNF MSN06-07R-CM Rep 3 (Conv)


title: TNF MSN08-13R-CM Rep 3 (Conv)


title: TNF MSN08-13R-CM Rep 4 (Conv)


title: TNF MSN08-13R-CM Rep 1 (Conv)


title: TNF MSN06-07R-CM Rep 2 (Conv)


title: TNF MSN05-01R-CM Rep 3 (Conv)


title: TNF MSN06-07R-CM Rep 1 (Conv)


title: TNF MSN05-01R-CM Rep 4 (Conv)


title: TNF MSN05-01R-CM Rep 2 (Conv)


title: TNF MSN01-03R-CM Rep 4 (Conv)


title: TNF MSN05-01R-CM Rep 1 (Conv)


title: TNF MSN02-04R-CM Rep 2 (Conv)


title: TNF MSN02-04R-CM Rep 3 (Conv)


title: SUN MSN09-04R-CM Rep 1 (Conv)

value: SUN

value: Sunitinib


title: SUN MSN09-04R-CM Rep 2 (Conv)

value: skin

value: cardiac myocytes


title: TNF MSN02-04R-CM Rep 4 (Conv)


title: TNF MSN01-03R-CM Rep 3 (Conv)


title: TNF MSN02-04R-CM Rep 1 (Conv)


title: SUN MSN09-04R-CM Rep 3 (Conv)


title: TNF MSN01-03R-CM Rep 1 (Conv)


title: SUN MSN08-13R-CM Rep 2 (Conv)


title: TNF MSN01-03R-CM Rep 2 (Conv)


title: TNF MSN08-13R-CM Rep 2 (Conv)


title: TNF MSN06-07R-CM Rep 4 (Conv)


title: SUN MSN08-13R-CM Rep 3 (Conv)


title: SUN MSN08-13R-CM Rep 1 (Conv)


title: SUN MSN05-01R-CM Rep 4 (Conv)


title: SUN MSN06-07R-CM Rep 3 (Conv)


title: SUN MSN06-07R-CM Rep 2 (Conv)


title: SUN MSN05-01R-CM Rep 3 (Conv)


title: SUN MSN06-07R-CM Rep 4 (Conv)


title: SUN MSN06-07R-CM Rep 1 (Conv)


title: SUN MSN02-04R-CM Rep 2 (Conv)


title: SUN MSN05-01R-CM Rep 2 (Conv)


title: SUN MSN05-01R-CM Rep 1 (Conv)


title: SUN MSN01-03R-CM Rep 4 (Conv)


title: SUN MSN01-03R-CM Rep 3 (Conv)


title: SUN MSN01-03R-CM Rep 2 (Conv)


title: SOR MSN09-04R-CM Rep 4 (Conv)

value: SOR

value: Sorafenib


title: SUN MSN01-03R-CM Rep 1 (Conv)


title: SOR MSN09-04R-CM Rep 3 (Conv)


title: SUN MSN08-13R-CM Rep 4 (Conv)


title: SOR MSN09-04R-CM Rep 2 (Conv)


title: SOR MSN08-13R-CM Rep 4 (Conv)


title: SOR MSN09-04R-CM Rep 1 (Conv)


title: SOR MSN08-13R-CM Rep 2 (Conv)


title: SOR MSN06-07R-CM Rep 1 (Conv)


title: SOR MSN08-13R-CM Rep 3 (Conv)


title: SOR MSN05-01R-CM Rep 3 (Conv)


title: SOR MSN05-01R-CM Rep 1 (Conv)


title: SOR MSN06-07R-CM Rep 2 (Conv)


title: SOR MSN05-01R-CM Rep 4 (Conv)


title: SOR MSN01-03R-CM Rep 4 (Conv)


title: SOR MSN01-03R-CM Rep 3 (Conv)


title: SOR MSN05-01R-CM Rep 2 (Conv)


title: SOR MSN01-03R-CM Rep 2 (Conv)


title: SUN MSN02-04R-CM Rep 1 (Conv)


title: SOR MSN01-03R-CM Rep 1 (Conv)


title: SAX MSN09-04R-CM Rep 3 (Conv)

value: SAX

value: Saxagliptin


title: SAX MSN09-04R-CM Rep 2 (Conv)


title: SAX MSN09-04R-CM Rep 4 (Conv)


title: SAX MSN08-13R-CM Rep 3 (Conv)


title: SAX MSN08-13R-CM Rep 2 (Conv)


title: SAX MSN06-07R-CM Rep 3 (Conv)


title: SAX MSN06-07R-CM Rep 2 (Conv)


title: SAX MSN08-13R-CM Rep 1 (Conv)


title: SAX MSN05-01R-CM Rep 4 (Conv)


title: SOR MSN08-13R-CM Rep 1 (Conv)


title: SAX MSN05-01R-CM Rep 2 (Conv)


title: SAX MSN02-04R-CM Rep 4 (Conv)


title: SAX MSN05-01R-CM Rep 3 (Conv)


title: SAX MSN02-04R-CM Rep 3 (Conv)


title: SAX MSN05-01R-CM Rep 1 (Conv)


title: SAX MSN02-04R-CM Rep 1 (Conv)


title: SAX MSN02-04R-CM Rep 2 (Conv)


title: SAX MSN01-03R-CM Rep 3 (Conv)


title: SAX MSN01-03R-CM Rep 2 (Conv)


title: SAX MSN01-03R-CM Rep 1 (Conv)


title: SAX MSN01-03R-CM Rep 4 (Conv)


title: RUX MSN09-04R-CM Rep 2 (Conv)

value: RUX

value: Ruxolitinib


title: RUX MSN09-04R-CM Rep 3 (Conv)


title: RUX MSN09-04R-CM Rep 1 (Conv)


title: RUX MSN09-04R-CM Rep 4 (Conv)


title: SAX MSN09-04R-CM Rep 1 (Conv)


title: RUX MSN08-13R-CM Rep 2 (Conv)


title: RUX MSN08-13R-CM Rep 4 (Conv)


title: RUX MSN08-13R-CM Rep 1 (Conv)


title: SAX MSN06-07R-CM Rep 1 (Conv)


title: RUX MSN06-07R-CM Rep 3 (Conv)


title: RUX MSN06-07R-CM Rep 1 (Conv)


title: RUX MSN05-01R-CM Rep 4 (Conv)


title: RUX MSN05-01R-CM Rep 3 (Conv)


title: RUX MSN05-01R-CM Rep 2 (Conv)


title: RUX MSN05-01R-CM Rep 1 (Conv)


title: RUX MSN06-07R-CM Rep 2 (Conv)


title: RUX MSN02-04R-CM Rep 4 (Conv)


title: RUX MSN01-03R-CM Rep 4 (Conv)


title: RUX MSN02-04R-CM Rep 2 (Conv)


title: RUX MSN01-03R-CM Rep 3 (Conv)


title: RUX MSN01-03R-CM Rep 2 (Conv)


title: RUX MSN02-04R-CM Rep 1 (Conv)


title: RUX MSN01-03R-CM Rep 1 (Conv)


title: RTX MSN09-04R-CM Rep 4 (Conv)

value: RTX

value: Rituximab


title: RTX MSN09-04R-CM Rep 3 (Conv)


title: RUX MSN08-13R-CM Rep 3 (Conv)


title: RTX MSN08-13R-CM Rep 3 (Conv)


title: RTX MSN09-04R-CM Rep 1 (Conv)


title: RTX MSN08-13R-CM Rep 2 (Conv)


title: RTX MSN08-13R-CM Rep 1 (Conv)


title: RTX MSN09-04R-CM Rep 2 (Conv)


title: RUX MSN06-07R-CM Rep 4 (Conv)


title: RTX MSN06-07R-CM Rep 4 (Conv)


title: RTX MSN06-07R-CM Rep 3 (Conv)


title: SAX MSN08-13R-CM Rep 4 (Conv)


title: RTX MSN05-01R-CM Rep 4 (Conv)


title: RTX MSN06-07R-CM Rep 2 (Conv)


title: RTX MSN05-01R-CM Rep 3 (Conv)


title: RTX MSN05-01R-CM Rep 1 (Conv)


title: RTX MSN01-03R-CM Rep 4 (Conv)


title: RTX MSN05-01R-CM Rep 2 (Conv)


title: RUX MSN02-04R-CM Rep 3 (Conv)


title: RTX MSN01-03R-CM Rep 2 (Conv)


title: RTX MSN01-03R-CM Rep 3 (Conv)


title: ROS MSN09-04R-CM Rep 3 (Conv)

value: ROS

value: Rosiglitazone


title: RTX MSN01-03R-CM Rep 1 (Conv)


title: ROS MSN09-04R-CM Rep 1 (Conv)


title: ROS MSN09-04R-CM Rep 2 (Conv)


title: ROS MSN08-13R-CM Rep 3 (Conv)


title: ROS MSN06-07R-CM Rep 1 (Conv)


title: ROS MSN08-13R-CM Rep 1 (Conv)


title: ROS MSN06-07R-CM Rep 3 (Conv)


title: ROS MSN06-07R-CM Rep 2 (Conv)


title: ROS MSN05-01R-CM Rep 4 (Conv)


title: ROS MSN05-01R-CM Rep 2 (Conv)


title: ROS MSN05-01R-CM Rep 3 (Conv)


title: ROS MSN02-04R-CM Rep 4 (Conv)


title: ROS MSN05-01R-CM Rep 1 (Conv)


title: ROS MSN02-04R-CM Rep 3 (Conv)


title: ROS MSN02-04R-CM Rep 2 (Conv)


title: ROS MSN01-03R-CM Rep 2 (Conv)


title: ROS MSN02-04R-CM Rep 1 (Conv)


title: ROS MSN01-03R-CM Rep 4 (Conv)


title: REG MSN09-04R-CM Rep 3 (Conv)

value: REG

value: Regorafenib


title: RTX MSN06-07R-CM Rep 1 (Conv)


title: REG MSN08-13R-CM Rep 2 (Conv)


title: REG MSN08-13R-CM Rep 4 (Conv)


title: ROS MSN01-03R-CM Rep 3 (Conv)


title: REG MSN08-13R-CM Rep 3 (Conv)


title: REG MSN08-13R-CM Rep 1 (Conv)


title: REG MSN09-04R-CM Rep 1 (Conv)


title: ROS MSN08-13R-CM Rep 2 (Conv)


title: REG MSN06-07R-CM Rep 4 (Conv)


title: REG MSN06-07R-CM Rep 3 (Conv)


title: REG MSN06-07R-CM Rep 2 (Conv)


title: REG MSN06-07R-CM Rep 1 (Conv)


title: REG MSN05-01R-CM Rep 4 (Conv)


title: REG MSN05-01R-CM Rep 3 (Conv)


title: REG MSN01-03R-CM Rep 4 (Conv)


title: REG MSN01-03R-CM Rep 3 (Conv)


title: REG MSN01-03R-CM Rep 2 (Conv)


title: REG MSN01-03R-CM Rep 1 (Conv)


title: PRE MSN09-04R-CM Rep 4 (Conv)

value: PRE

value: Prednisolone


title: PRE MSN09-04R-CM Rep 2 (Conv)


title: PRE MSN09-04R-CM Rep 1 (Conv)


title: PRE MSN09-04R-CM Rep 3 (Conv)


title: PRE MSN08-13R-CM Rep 4 (Conv)


title: PRE MSN08-13R-CM Rep 1 (Conv)


title: PRE MSN08-13R-CM Rep 3 (Conv)


title: PRE MSN08-13R-CM Rep 2 (Conv)


title: REG MSN05-01R-CM Rep 1 (Conv)


title: PRE MSN06-07R-CM Rep 3 (Conv)


title: PRE MSN06-07R-CM Rep 2 (Conv)


title: PRE MSN02-04R-CM Rep 2 (Conv)


title: PRE MSN06-07R-CM Rep 1 (Conv)


title: PRE MSN05-01R-CM Rep 3 (Conv)


title: PRE MSN05-01R-CM Rep 4 (Conv)


title: PRE MSN05-01R-CM Rep 2 (Conv)


title: PRE MSN01-03R-CM Rep 4 (Conv)


title: PRE MSN02-04R-CM Rep 1 (Conv)


title: PON MSN09-04R-CM Rep 4 (Conv)

value: PON

value: Ponatinib


title: PRE MSN01-03R-CM Rep 3 (Conv)

value: skin

value: cardiac myocytes


title: REG MSN05-01R-CM Rep 2 (Conv)


title: PON MSN09-04R-CM Rep 3 (Conv)


title: PON MSN09-04R-CM Rep 2 (Conv)


title: REG MSN09-04R-CM Rep 2 (Conv)


title: PON MSN08-13R-CM Rep 2 (Conv)


title: PON MSN08-13R-CM Rep 1 (Conv)


title: PON MSN09-04R-CM Rep 1 (Conv)


title: PON MSN06-07R-CM Rep 4 (Conv)


title: PON MSN08-13R-CM Rep 3 (Conv)


title: PON MSN06-07R-CM Rep 3 (Conv)


title: PON MSN05-01R-CM Rep 4 (Conv)


title: PRE MSN01-03R-CM Rep 2 (Conv)


title: PON MSN06-07R-CM Rep 2 (Conv)


title: PRE MSN05-01R-CM Rep 1 (Conv)


title: PON MSN05-01R-CM Rep 2 (Conv)


title: PON MSN06-07R-CM Rep 1 (Conv)


title: PON MSN05-01R-CM Rep 1 (Conv)


title: PON MSN02-04R-CM Rep 2 (Conv)


title: PRE MSN01-03R-CM Rep 1 (Conv)


title: PON MSN01-03R-CM Rep 2 (Conv)


title: PON MSN01-03R-CM Rep 4 (Conv)


title: PON MSN01-03R-CM Rep 1 (Conv)


title: PIO MSN09-04R-CM Rep 4 (Conv)

value: PIO

value: Pioglitazone


title: PIO MSN09-04R-CM Rep 2 (Conv)


title: PIO MSN09-04R-CM Rep 3 (Conv)


title: PON MSN08-13R-CM Rep 4 (Conv)


title: PON MSN01-03R-CM Rep 3 (Conv)


title: PIO MSN08-13R-CM Rep 3 (Conv)


title: PIO MSN09-04R-CM Rep 1 (Conv)


title: PIO MSN08-13R-CM Rep 2 (Conv)


title: PIO MSN08-13R-CM Rep 1 (Conv)


title: PIO MSN06-07R-CM Rep 2 (Conv)


title: PIO MSN05-01R-CM Rep 4 (Conv)


title: PON MSN05-01R-CM Rep 3 (Conv)


title: PIO MSN06-07R-CM Rep 1 (Conv)


title: PIO MSN02-04R-CM Rep 2 (Conv)


title: PIO MSN05-01R-CM Rep 3 (Conv)


title: PIO MSN05-01R-CM Rep 2 (Conv)


title: PIO MSN05-01R-CM Rep 1 (Conv)


title: PIO MSN02-04R-CM Rep 1 (Conv)


title: PIO MSN01-03R-CM Rep 4 (Conv)


title: PON MSN02-04R-CM Rep 1 (Conv)


title: PIO MSN01-03R-CM Rep 3 (Conv)


title: PIO MSN02-04R-CM Rep 4 (Conv)


title: PIO MSN01-03R-CM Rep 1 (Conv)


title: PHP MSN09-04R-CM Rep 4 (Conv)

value: PHP

value: Phenylephrine


title: PHP MSN09-04R-CM Rep 2 (Conv)


title: PHP MSN09-04R-CM Rep 3 (Conv)


title: PIO MSN02-04R-CM Rep 3 (Conv)


title: PHP MSN08-13R-CM Rep 3 (Conv)


title: PHP MSN09-04R-CM Rep 1 (Conv)


title: PHP MSN08-13R-CM Rep 2 (Conv)


title: PHP MSN08-13R-CM Rep 4 (Conv)


title: PHP MSN06-07R-CM Rep 3 (Conv)


title: PHP MSN05-01R-CM Rep 4 (Conv)


title: PHP MSN06-07R-CM Rep 4 (Conv)


title: PHP MSN06-07R-CM Rep 2 (Conv)


title: PHP MSN06-07R-CM Rep 1 (Conv)


title: PIO MSN08-13R-CM Rep 4 (Conv)


title: PHP MSN05-01R-CM Rep 3 (Conv)


title: PHP MSN05-01R-CM Rep 1 (Conv)


title: PIO MSN01-03R-CM Rep 2 (Conv)


title: PHP MSN01-03R-CM Rep 2 (Conv)


title: PHP MSN05-01R-CM Rep 2 (Conv)


title: PHP MSN01-03R-CM Rep 1 (Conv)


title: PHP MSN01-03R-CM Rep 4 (Conv)


title: PAZ MSN09-04R-CM Rep 4 (Conv)

value: PAZ

value: Pazopanib


title: PAZ MSN08-13R-CM Rep 3 (Conv)


title: PAZ MSN09-04R-CM Rep 3 (Conv)


title: PAZ MSN08-13R-CM Rep 2 (Conv)


title: PAZ MSN06-07R-CM Rep 4 (Conv)


title: PAZ MSN05-01R-CM Rep 4 (Conv)


title: PAZ MSN09-04R-CM Rep 1 (Conv)


title: PHP MSN08-13R-CM Rep 1 (Conv)


title: PAZ MSN09-04R-CM Rep 2 (Conv)


title: PAZ MSN08-13R-CM Rep 1 (Conv)


title: PAZ MSN05-01R-CM Rep 1 (Conv)


title: PAZ MSN05-01R-CM Rep 3 (Conv)


title: PAZ MSN01-03R-CM Rep 4 (Conv)


title: PHP MSN01-03R-CM Rep 3 (Conv)


title: PAZ MSN01-03R-CM Rep 1 (Conv)


title: PAZ MSN01-03R-CM Rep 2 (Conv)


title: OLM MSN09-04R-CM Rep 2 (Conv)

value: OLM

value: Olmesartan


title: OLM MSN09-04R-CM Rep 3 (Conv)


title: PAZ MSN05-01R-CM Rep 2 (Conv)


title: PAZ MSN08-13R-CM Rep 4 (Conv)


title: OLM MSN08-13R-CM Rep 3 (Conv)


title: OLM MSN08-13R-CM Rep 2 (Conv)


title: OLM MSN09-04R-CM Rep 1 (Conv)


title: OLM MSN08-13R-CM Rep 4 (Conv)


title: OLM MSN09-04R-CM Rep 4 (Conv)


title: OLM MSN06-07R-CM Rep 2 (Conv)


title: PAZ MSN06-07R-CM Rep 3 (Conv)


title: OLM MSN06-07R-CM Rep 3 (Conv)


title: PAZ MSN06-07R-CM Rep 1 (Conv)


title: OLM MSN08-13R-CM Rep 1 (Conv)


title: OLM MSN05-01R-CM Rep 4 (Conv)


title: OLM MSN05-01R-CM Rep 2 (Conv)


title: PAZ MSN06-07R-CM Rep 2 (Conv)


title: OLM MSN05-01R-CM Rep 1 (Conv)


title: PAZ MSN01-03R-CM Rep 3 (Conv)


title: OLM MSN02-04R-CM Rep 2 (Conv)


title: OLM MSN01-03R-CM Rep 4 (Conv)


title: OLM MSN01-03R-CM Rep 3 (Conv)


title: OLM MSN01-03R-CM Rep 2 (Conv)


title: OLM MSN05-01R-CM Rep 3 (Conv)


title: NIL MSN09-04R-CM Rep 2 (Conv)

value: Nilotinib


title: OLM MSN01-03R-CM Rep 1 (Conv)


title: NIL MSN09-04R-CM Rep 1 (Conv)


title: NIL MSN08-13R-CM Rep 3 (Conv)


title: NIL MSN08-13R-CM Rep 4 (Conv)


title: NIL MSN09-04R-CM Rep 3 (Conv)


title: NIL MSN08-13R-CM Rep 1 (Conv)


title: NIL MSN09-04R-CM Rep 4 (Conv)


title: NIL MSN06-07R-CM Rep 2 (Conv)


title: OLM MSN06-07R-CM Rep 1 (Conv)


title: NIL MSN06-07R-CM Rep 3 (Conv)


title: NIL MSN05-01R-CM Rep 4 (Conv)


title: ROS MSN01-03R-CM Rep 1 (Conv)

value: ROS

value: Rosiglitazone


title: OLM MSN02-04R-CM Rep 1 (Conv)


title: NIL MSN05-01R-CM Rep 2 (Conv)


title: NIL MSN01-03R-CM Rep 4 (Conv)


title: NIL MSN05-01R-CM Rep 1 (Conv)


title: NIL MSN01-03R-CM Rep 1 (Conv)


title: NIL MSN01-03R-CM Rep 2 (Conv)


title: NIL MSN01-03R-CM Rep 3 (Conv)


title: MIL MSN09-04R-CM Rep 4 (Conv)

value: MIL

value: Milrinone


title: MIL MSN09-04R-CM Rep 3 (Conv)


title: MIL MSN09-04R-CM Rep 2 (Conv)


title: MIL MSN09-04R-CM Rep 1 (Conv)


title: MIL MSN08-13R-CM Rep 4 (Conv)


title: NIL MSN08-13R-CM Rep 2 (Conv)


title: MIL MSN08-13R-CM Rep 1 (Conv)


title: MIL MSN08-13R-CM Rep 2 (Conv)


title: MIL MSN08-13R-CM Rep 3 (Conv)


title: MIL MSN06-07R-CM Rep 4 (Conv)


title: NIL MSN06-07R-CM Rep 1 (Conv)


title: MIL MSN05-01R-CM Rep 3 (Conv)


title: NIL MSN05-01R-CM Rep 3 (Conv)


title: MIL MSN05-01R-CM Rep 1 (Conv)


title: MIL MSN06-07R-CM Rep 1 (Conv)


title: MIL MSN02-04R-CM Rep 1 (Conv)


title: MIL MSN06-07R-CM Rep 2 (Conv)


title: LAP MSN09-04R-CM Rep 4 (Conv)

value: LAP

value: Lapatinib


title: MIL MSN02-04R-CM Rep 2 (Conv)

value: skin


title: MIL MSN01-03R-CM Rep 1 (Conv)

value: cardiac myocytes


title: LAP MSN09-04R-CM Rep 2 (Conv)


title: LAP MSN09-04R-CM Rep 3 (Conv)


title: MIL MSN01-03R-CM Rep 3 (Conv)


title: LAP MSN08-13R-CM Rep 3 (Conv)


title: LAP MSN09-04R-CM Rep 1 (Conv)


title: MIL MSN01-03R-CM Rep 2 (Conv)


title: LAP MSN08-13R-CM Rep 4 (Conv)


title: LAP MSN08-13R-CM Rep 1 (Conv)


title: LAP MSN06-07R-CM Rep 3 (Conv)


title: MIL MSN01-03R-CM Rep 4 (Conv)


title: MIL MSN06-07R-CM Rep 3 (Conv)


title: LAP MSN06-07R-CM Rep 1 (Conv)


title: LAP MSN08-13R-CM Rep 2 (Conv)


title: LAP MSN05-01R-CM Rep 3 (Conv)


title: MIL MSN05-01R-CM Rep 2 (Conv)


title: MIL MSN05-01R-CM Rep 4 (Conv)


title: LAP MSN05-01R-CM Rep 2 (Conv)


title: LAP MSN01-03R-CM Rep 4 (Conv)


title: LAP MSN05-01R-CM Rep 1 (Conv)


title: LAP MSN01-03R-CM Rep 3 (Conv)


title: LAP MSN05-01R-CM Rep 4 (Conv)


title: LAP MSN01-03R-CM Rep 2 (Conv)


title: LAP MSN01-03R-CM Rep 1 (Conv)


title: ISO MSN09-04R-CM Rep 4 (Conv)

value: ISO

value: Isoproterenol


title: ISO MSN09-04R-CM Rep 2 (Conv)


title: ISO MSN09-04R-CM Rep 3 (Conv)


title: ISO MSN09-04R-CM Rep 1 (Conv)


title: ISO MSN08-13R-CM Rep 3 (Conv)


title: ISO MSN08-13R-CM Rep 1 (Conv)


title: ISO MSN06-07R-CM Rep 2 (Conv)


title: ISO MSN08-13R-CM Rep 2 (Conv)


title: ISO MSN08-13R-CM Rep 4 (Conv)


title: ISO MSN06-07R-CM Rep 1 (Conv)


title: ISO MSN05-01R-CM Rep 1 (Conv)


title: ISO MSN05-01R-CM Rep 3 (Conv)


title: LAP MSN06-07R-CM Rep 2 (Conv)


title: ISO MSN05-01R-CM Rep 2 (Conv)


title: ISO MSN01-03R-CM Rep 2 (Conv)


title: ISO MSN01-03R-CM Rep 3 (Conv)


title: IMA MSN09-04R-CM Rep 3 (Conv)

value: IMA

value: Imatinib


title: ISO MSN01-03R-CM Rep 1 (Conv)


title: IMA MSN09-04R-CM Rep 2 (Conv)


title: ISO MSN01-03R-CM Rep 4 (Conv)


title: IMA MSN09-04R-CM Rep 4 (Conv)


title: IMA MSN09-04R-CM Rep 1 (Conv)


title: IMA MSN08-13R-CM Rep 2 (Conv)


title: IMA MSN08-13R-CM Rep 4 (Conv)


title: IMA MSN08-13R-CM Rep 1 (Conv)


title: IMA MSN06-07R-CM Rep 3 (Conv)


title: IMA MSN08-13R-CM Rep 3 (Conv)


title: IMA MSN06-07R-CM Rep 2 (Conv)


title: IMA MSN05-01R-CM Rep 4 (Conv)


title: IMA MSN05-01R-CM Rep 3 (Conv)


title: IMA MSN06-07R-CM Rep 1 (Conv)


title: ISO MSN05-01R-CM Rep 4 (Conv)


title: IMA MSN05-01R-CM Rep 1 (Conv)


title: IMA MSN02-04R-CM Rep 1 (Conv)


title: IMA MSN02-04R-CM Rep 2 (Conv)


title: IMA MSN01-03R-CM Rep 4 (Conv)


title: IMA MSN01-03R-CM Rep 3 (Conv)


title: IMA MSN01-03R-CM Rep 2 (Conv)


title: IMA MSN01-03R-CM Rep 1 (Conv)


title: IGF MSN09-04R-CM Rep 2 (Conv)

value: IGF


title: IGF MSN09-04R-CM Rep 1 (Conv)


title: IGF MSN09-04R-CM Rep 3 (Conv)


title: IGF MSN08-13R-CM Rep 4 (Conv)


title: IGF MSN08-13R-CM Rep 3 (Conv)


title: IGF MSN06-07R-CM Rep 1 (Conv)


title: IGF MSN08-13R-CM Rep 1 (Conv)


title: IGF MSN06-07R-CM Rep 3 (Conv)


title: IGF MSN06-07R-CM Rep 4 (Conv)


title: IGF MSN05-01R-CM Rep 4 (Conv)


title: IGF MSN05-01R-CM Rep 3 (Conv)


title: IGF MSN02-04R-CM Rep 3 (Conv)


title: IGF MSN02-04R-CM Rep 2 (Conv)


title: IMA MSN05-01R-CM Rep 2 (Conv)


title: IGF MSN02-04R-CM Rep 4 (Conv)


title: IGF MSN02-04R-CM Rep 1 (Conv)


title: IGF MSN01-03R-CM Rep 4 (Conv)


title: IGF MSN05-01R-CM Rep 1 (Conv)


title: IDA MSN09-04R-CM Rep 4 (Conv)

value: IDA

value: Idarubicin


title: IGF MSN01-03R-CM Rep 3 (Conv)


title: IGF MSN01-03R-CM Rep 1 (Conv)


title: IDA MSN09-04R-CM Rep 3 (Conv)


title: IDA MSN08-13R-CM Rep 4 (Conv)


title: IDA MSN06-07R-CM Rep 4 (Conv)


title: IDA MSN09-04R-CM Rep 2 (Conv)


title: IGF MSN01-03R-CM Rep 2 (Conv)


title: IDA MSN06-07R-CM Rep 2 (Conv)


title: IDA MSN09-04R-CM Rep 1 (Conv)


title: IDA MSN08-13R-CM Rep 1 (Conv)


title: IDA MSN08-13R-CM Rep 3 (Conv)


title: IDA MSN05-01R-CM Rep 4 (Conv)


title: IDA MSN08-13R-CM Rep 2 (Conv)


title: IDA MSN06-07R-CM Rep 1 (Conv)


title: IGF MSN08-13R-CM Rep 2 (Conv)


title: IGF MSN06-07R-CM Rep 2 (Conv)


title: IDA MSN05-01R-CM Rep 1 (Conv)


title: IGF MSN05-01R-CM Rep 2 (Conv)


title: IDA MSN05-01R-CM Rep 3 (Conv)


title: IDA MSN05-01R-CM Rep 2 (Conv)


title: IDA MSN01-03R-CM Rep 4 (Conv)


title: GEF MSN09-04R-CM Rep 3 (Conv)

value: GEF

value: Gefitinib


title: GEF MSN09-04R-CM Rep 1 (Conv)


title: IDA MSN01-03R-CM Rep 2 (Conv)


title: IDA MSN01-03R-CM Rep 1 (Conv)


title: GEF MSN08-13R-CM Rep 4 (Conv)


title: GEF MSN09-04R-CM Rep 2 (Conv)


title: IDA MSN06-07R-CM Rep 3 (Conv)


title: GEF MSN08-13R-CM Rep 2 (Conv)


title: GEF MSN05-01R-CM Rep 4 (Conv)


title: GEF MSN06-07R-CM Rep 4 (Conv)


title: GEF MSN06-07R-CM Rep 3 (Conv)


title: GEF MSN06-07R-CM Rep 2 (Conv)


title: GEF MSN05-01R-CM Rep 3 (Conv)


title: GEF MSN05-01R-CM Rep 1 (Conv)


title: GEF MSN08-13R-CM Rep 3 (Conv)


title: GEF MSN06-07R-CM Rep 1 (Conv)


title: IDA MSN01-03R-CM Rep 3 (Conv)


title: GEF MSN01-03R-CM Rep 4 (Conv)


title: GEF MSN01-03R-CM Rep 2 (Conv)


title: GEF MSN01-03R-CM Rep 3 (Conv)


title: FLE MSN09-04R-CM Rep 2 (Conv)

value: FLE

value: Flecainide


title: FLE MSN09-04R-CM Rep 3 (Conv)


title: FLE MSN08-13R-CM Rep 4 (Conv)


title: FLE MSN08-13R-CM Rep 3 (Conv)


title: FLE MSN09-04R-CM Rep 4 (Conv)


title: GEF MSN05-01R-CM Rep 2 (Conv)


title: FLE MSN09-04R-CM Rep 1 (Conv)


title: FLE MSN08-13R-CM Rep 1 (Conv)


title: FLE MSN06-07R-CM Rep 3 (Conv)


title: FLE MSN08-13R-CM Rep 2 (Conv)


title: FLE MSN06-07R-CM Rep 2 (Conv)


title: GEF MSN01-03R-CM Rep 1 (Conv)


title: FLE MSN06-07R-CM Rep 1 (Conv)


title: FLE MSN05-01R-CM Rep 4 (Conv)


title: FLE MSN05-01R-CM Rep 3 (Conv)


title: GEF MSN08-13R-CM Rep 1 (Conv)


title: FLE MSN05-01R-CM Rep 2 (Conv)


title: FLE MSN05-01R-CM Rep 1 (Conv)


title: FLE MSN01-03R-CM Rep 2 (Conv)


title: FLE MSN02-04R-CM Rep 2 (Conv)


title: FLE MSN01-03R-CM Rep 4 (Conv)


title: FLE MSN01-03R-CM Rep 3 (Conv)


title: FLE MSN01-03R-CM Rep 1 (Conv)


title: FLE MSN02-04R-CM Rep 1 (Conv)


title: EST MSN09-04R-CM Rep 4 (Conv)

value: EST

value: Estradiol


title: EST MSN08-13R-CM Rep 1 (Conv)


title: EST MSN06-07R-CM Rep 4 (Conv)


title: EST MSN08-13R-CM Rep 2 (Conv)


title: EST MSN09-04R-CM Rep 3 (Conv)


title: EST MSN05-01R-CM Rep 3 (Conv)


title: EST MSN06-07R-CM Rep 3 (Conv)


title: EST MSN06-07R-CM Rep 2 (Conv)


title: EST MSN06-07R-CM Rep 1 (Conv)


title: EST MSN09-04R-CM Rep 1 (Conv)


title: EST MSN05-01R-CM Rep 4 (Conv)


title: EST MSN05-01R-CM Rep 2 (Conv)


title: EST MSN08-13R-CM Rep 3 (Conv)


title: EST MSN09-04R-CM Rep 2 (Conv)


title: EST MSN02-04R-CM Rep 1 (Conv)


title: EST MSN01-03R-CM Rep 4 (Conv)


title: EST MSN02-04R-CM Rep 2 (Conv)


title: ERL MSN09-04R-CM Rep 4 (Conv)

value: ERL

value: Erlotinib


title: EST MSN05-01R-CM Rep 1 (Conv)

value: skin


title: EST MSN01-03R-CM Rep 3 (Conv)

value: cardiac myocytes


title: ERL MSN09-04R-CM Rep 3 (Conv)


title: ERL MSN08-13R-CM Rep 1 (Conv)


title: ERL MSN09-04R-CM Rep 1 (Conv)


title: ERL MSN08-13R-CM Rep 2 (Conv)


title: ERL MSN08-13R-CM Rep 4 (Conv)


title: ERL MSN09-04R-CM Rep 2 (Conv)


title: ERL MSN06-07R-CM Rep 1 (Conv)


title: ERL MSN05-01R-CM Rep 4 (Conv)


title: ERL MSN05-01R-CM Rep 1 (Conv)


title: ERL MSN08-13R-CM Rep 3 (Conv)


title: ERL MSN01-03R-CM Rep 3 (Conv)


title: ERL MSN01-03R-CM Rep 4 (Conv)


title: ERL MSN01-03R-CM Rep 1 (Conv)


title: EST MSN01-03R-CM Rep 1 (Conv)


title: EST MSN01-03R-CM Rep 2 (Conv)


title: EPI MSN08-13R-CM Rep 3 (Conv)

value: EPI

value: Epirubicin


title: EPI MSN08-13R-CM Rep 2 (Conv)


title: EPI MSN09-04R-CM Rep 1 (Conv)


title: EPI MSN08-13R-CM Rep 1 (Conv)


title: ERL MSN01-03R-CM Rep 2 (Conv)


title: EPI MSN09-04R-CM Rep 2 (Conv)


title: ERL MSN05-01R-CM Rep 3 (Conv)


title: EPI MSN06-07R-CM Rep 4 (Conv)


title: EPI MSN06-07R-CM Rep 3 (Conv)


title: EPI MSN06-07R-CM Rep 2 (Conv)


title: EPI MSN06-07R-CM Rep 1 (Conv)


title: ERL MSN06-07R-CM Rep 2 (Conv)


title: EPI MSN05-01R-CM Rep 3 (Conv)


title: ERL MSN05-01R-CM Rep 2 (Conv)


title: EPI MSN05-01R-CM Rep 1 (Conv)


title: EPI MSN05-01R-CM Rep 4 (Conv)


title: EPI MSN01-03R-CM Rep 4 (Conv)


title: EPI MSN01-03R-CM Rep 2 (Conv)


title: EDN MSN09-04R-CM Rep 3 (Conv)

value: EDN

value: Endothelin


title: EDN MSN09-04R-CM Rep 2 (Conv)


title: EDN MSN08-13R-CM Rep 4 (Conv)


title: EDN MSN08-13R-CM Rep 3 (Conv)


title: EDN MSN08-13R-CM Rep 2 (Conv)


title: EDN MSN05-01R-CM Rep 4 (Conv)


title: EDN MSN06-07R-CM Rep 3 (Conv)


title: EDN MSN06-07R-CM Rep 2 (Conv)


title: EDN MSN05-01R-CM Rep 2 (Conv)


title: EDN MSN05-01R-CM Rep 3 (Conv)


title: EDN MSN02-04R-CM Rep 2 (Conv)


title: EDN MSN08-13R-CM Rep 1 (Conv)


title: EDN MSN05-01R-CM Rep 1 (Conv)


title: EDN MSN02-04R-CM Rep 3 (Conv)


title: EDN MSN02-04R-CM Rep 4 (Conv)


title: EDN MSN01-03R-CM Rep 4 (Conv)


title: EPI MSN05-01R-CM Rep 2 (Conv)


title: EDN MSN02-04R-CM Rep 1 (Conv)


title: EDN MSN01-03R-CM Rep 2 (Conv)


title: EDN MSN01-03R-CM Rep 1 (Conv)


title: DOX MSN09-04R-CM Rep 3 (Conv)

value: DOX

value: Doxorubicin


title: EDN MSN01-03R-CM Rep 3 (Conv)


title: EPI MSN01-03R-CM Rep 1 (Conv)


title: DOX MSN09-04R-CM Rep 2 (Conv)


title: DOX MSN08-13R-CM Rep 4 (Conv)


title: DOX MSN09-04R-CM Rep 1 (Conv)


title: DOX MSN08-13R-CM Rep 2 (Conv)


title: EDN MSN09-04R-CM Rep 1 (Conv)


title: EDN MSN06-07R-CM Rep 1 (Conv)


title: EPI MSN01-03R-CM Rep 3 (Conv)


title: DOX MSN08-13R-CM Rep 1 (Conv)


title: DOX MSN08-13R-CM Rep 3 (Conv)


title: DOX MSN06-07R-CM Rep 4 (Conv)


title: DOX MSN05-01R-CM Rep 3 (Conv)


title: DOX MSN06-07R-CM Rep 2 (Conv)


title: DOX MSN05-01R-CM Rep 1 (Conv)


title: DOX MSN05-01R-CM Rep 4 (Conv)


title: DOX MSN06-07R-CM Rep 3 (Conv)


title: DOX MSN01-03R-CM Rep 4 (Conv)


title: DOX MSN06-07R-CM Rep 1 (Conv)


title: DOX MSN01-03R-CM Rep 3 (Conv)


title: DOX MSN05-01R-CM Rep 2 (Conv)


title: DOB MSN09-04R-CM Rep 1 (Conv)

value: DOB

value: Dobutamine


title: DOX MSN01-03R-CM Rep 1 (Conv)


title: DOB MSN09-04R-CM Rep 2 (Conv)


title: DOB MSN08-13R-CM Rep 4 (Conv)


title: DOX MSN01-03R-CM Rep 2 (Conv)


title: DOB MSN08-13R-CM Rep 1 (Conv)


title: DOB MSN08-13R-CM Rep 2 (Conv)


title: DOB MSN08-13R-CM Rep 3 (Conv)


title: DOB MSN06-07R-CM Rep 3 (Conv)


title: DOB MSN06-07R-CM Rep 2 (Conv)


title: DOB MSN06-07R-CM Rep 4 (Conv)


title: DOB MSN05-01R-CM Rep 3 (Conv)


title: DOB MSN05-01R-CM Rep 1 (Conv)


title: DOB MSN05-01R-CM Rep 2 (Conv)


title: DOB MSN01-03R-CM Rep 4 (Conv)


title: DOB MSN01-03R-CM Rep 2 (Conv)


title: DOB MSN01-03R-CM Rep 3 (Conv)


title: DIC MSN09-04R-CM Rep 2 (Conv)

value: DIC

value: Diclofenac


title: DIC MSN09-04R-CM Rep 1 (Conv)


title: DIC MSN08-13R-CM Rep 3 (Conv)


title: DOB MSN09-04R-CM Rep 3 (Conv)


title: DOB MSN01-03R-CM Rep 1 (Conv)


title: DIC MSN08-13R-CM Rep 4 (Conv)


title: DOB MSN09-04R-CM Rep 4 (Conv)


title: DIC MSN09-04R-CM Rep 4 (Conv)


title: DIC MSN08-13R-CM Rep 2 (Conv)


title: DIC MSN05-01R-CM Rep 3 (Conv)


title: DIC MSN05-01R-CM Rep 4 (Conv)


title: DIC MSN06-07R-CM Rep 3 (Conv)


title: DIC MSN05-01R-CM Rep 1 (Conv)


title: DIC MSN06-07R-CM Rep 2 (Conv)


title: DIC MSN05-01R-CM Rep 2 (Conv)


title: DOB MSN06-07R-CM Rep 1 (Conv)


title: DIC MSN08-13R-CM Rep 1 (Conv)


title: DIC MSN06-07R-CM Rep 1 (Conv)


title: DOB MSN05-01R-CM Rep 4 (Conv)


title: DIC MSN02-04R-CM Rep 2 (Conv)


title: DIC MSN02-04R-CM Rep 3 (Conv)


title: DIC MSN01-03R-CM Rep 4 (Conv)


title: DIC MSN01-03R-CM Rep 2 (Conv)


title: DIC MSN01-03R-CM Rep 3 (Conv)


title: DIC MSN09-04R-CM Rep 3 (Conv)


title: DEL MSN09-04R-CM Rep 4 (Conv)

value: DEL

value: Delavirdine


title: DEL MSN09-04R-CM Rep 2 (Conv)


title: DEL MSN09-04R-CM Rep 3 (Conv)


title: DEL MSN08-13R-CM Rep 4 (Conv)


title: DIC MSN06-07R-CM Rep 4 (Conv)


title: DEL MSN08-13R-CM Rep 3 (Conv)


title: DIC MSN02-04R-CM Rep 1 (Conv)


title: DEL MSN08-13R-CM Rep 1 (Conv)


title: DEL MSN06-07R-CM Rep 4 (Conv)


title: DEL MSN06-07R-CM Rep 3 (Conv)


title: DEL MSN06-07R-CM Rep 2 (Conv)


title: DEL MSN05-01R-CM Rep 2 (Conv)


title: DEL MSN05-01R-CM Rep 3 (Conv)


title: DEL MSN05-01R-CM Rep 1 (Conv)


title: DEL MSN05-01R-CM Rep 4 (Conv)


title: DEL MSN02-04R-CM Rep 4 (Conv)


title: DEL MSN02-04R-CM Rep 3 (Conv)


title: DEL MSN02-04R-CM Rep 1 (Conv)


title: DEL MSN01-03R-CM Rep 4 (Conv)


title: DEL MSN01-03R-CM Rep 2 (Conv)


title: DIC MSN02-04R-CM Rep 4 (Conv)


title: DEL MSN02-04R-CM Rep 2 (Conv)


title: DIC MSN01-03R-CM Rep 1 (Conv)


title: DEC MSN09-04R-CM Rep 2 (Conv)

value: DEC

value: Decitabine


title: DEC MSN09-04R-CM Rep 1 (Conv)


title: DEL MSN09-04R-CM Rep 1 (Conv)


title: DEL MSN08-13R-CM Rep 2 (Conv)


title: DEC MSN08-13R-CM Rep 4 (Conv)


title: DEC MSN08-13R-CM Rep 2 (Conv)


title: DEC MSN08-13R-CM Rep 1 (Conv)


title: DEC MSN06-07R-CM Rep 4 (Conv)


title: DEC MSN06-07R-CM Rep 1 (Conv)


title: DEC MSN05-01R-CM Rep 4 (Conv)


title: DEC MSN06-07R-CM Rep 2 (Conv)


title: DEL MSN06-07R-CM Rep 1 (Conv)


title: DEC MSN05-01R-CM Rep 1 (Conv)


title: DEL MSN01-03R-CM Rep 3 (Conv)


title: DEC MSN06-07R-CM Rep 3 (Conv)


title: DEC MSN02-04R-CM Rep 3 (Conv)


title: DEC MSN05-01R-CM Rep 3 (Conv)


title: DEC MSN02-04R-CM Rep 4 (Conv)


title: DEL MSN01-03R-CM Rep 1 (Conv)


title: DEC MSN01-03R-CM Rep 2 (Conv)


title: DEC MSN05-01R-CM Rep 2 (Conv)


title: DEC MSN08-13R-CM Rep 3 (Conv)


title: DEC MSN02-04R-CM Rep 1 (Conv)


title: DAU MSN08-13R-CM Rep 4 (Conv)

value: DAU

value: Daunorubicin


title: DAU MSN09-04R-CM Rep 2 (Conv)

value: skin

value: cardiac myocytes


title: DAU MSN09-04R-CM Rep 1 (Conv)


title: DEC MSN01-03R-CM Rep 1 (Conv)


title: DAU MSN08-13R-CM Rep 2 (Conv)


title: DAU MSN08-13R-CM Rep 3 (Conv)


title: DAU MSN09-04R-CM Rep 3 (Conv)


title: DAU MSN08-13R-CM Rep 1 (Conv)


title: DEC MSN01-03R-CM Rep 3 (Conv)


title: DAU MSN06-07R-CM Rep 4 (Conv)


title: DAU MSN06-07R-CM Rep 1 (Conv)


title: DEC MSN02-04R-CM Rep 2 (Conv)


title: DAU MSN06-07R-CM Rep 2 (Conv)


title: DAU MSN06-07R-CM Rep 3 (Conv)


title: DAU MSN08-13R-CM Rep 5 (Conv)


title: DAU MSN05-01R-CM Rep 4 (Conv)


title: DAU MSN05-01R-CM Rep 3 (Conv)


title: DAU MSN02-04R-CM Rep 4 (Conv)


title: DEC MSN01-03R-CM Rep 4 (Conv)


title: DAU MSN01-03R-CM Rep 4 (Conv)


title: DAU MSN02-04R-CM Rep 1 (Conv)


title: DAU MSN05-01R-CM Rep 1 (Conv)


title: DAU MSN01-03R-CM Rep 3 (Conv)


title: DAU MSN01-03R-CM Rep 2 (Conv)


title: DAU MSN02-04R-CM Rep 2 (Conv)


title: DAS MSN09-04R-CM Rep 3 (Conv)

value: DAS

value: Dasatinib


title: DAS MSN09-04R-CM Rep 2 (Conv)


title: DAS MSN09-04R-CM Rep 4 (Conv)


title: DAU MSN01-03R-CM Rep 1 (Conv)


title: DAU MSN02-04R-CM Rep 3 (Conv)


title: DAS MSN08-13R-CM Rep 4 (Conv)


title: DAS MSN09-04R-CM Rep 1 (Conv)


title: DAS MSN08-13R-CM Rep 2 (Conv)


title: DAS MSN05-01R-CM Rep 3 (Conv)


title: DAS MSN06-07R-CM Rep 1 (Conv)


title: DAS MSN08-13R-CM Rep 1 (Conv)


title: DAS MSN01-03R-CM Rep 4 (Conv)


title: DAU MSN05-01R-CM Rep 2 (Conv)


title: DAS MSN01-03R-CM Rep 2 (Conv)


title: DAS MSN06-07R-CM Rep 2 (Conv)


title: DAS MSN05-01R-CM Rep 1 (Conv)


title: DAS MSN08-13R-CM Rep 3 (Conv)


title: DAS MSN05-01R-CM Rep 2 (Conv)


title: DAS MSN05-01R-CM Rep 4 (Conv)


title: DAS MSN01-03R-CM Rep 1 (Conv)


title: DAS MSN01-03R-CM Rep 3 (Conv)


title: DAB MSN09-04R-CM Rep 2 (Conv)

value: DAB

value: Dabrafenib


title: DAB MSN09-04R-CM Rep 1 (Conv)


title: DAB MSN09-04R-CM Rep 4 (Conv)


title: DAB MSN08-13R-CM Rep 4 (Conv)


title: DAB MSN05-01R-CM Rep 4 (Conv)


title: DAB MSN08-13R-CM Rep 2 (Conv)


title: DAB MSN08-13R-CM Rep 1 (Conv)


title: DAB MSN06-07R-CM Rep 1 (Conv)


title: DAS MSN06-07R-CM Rep 3 (Conv)


title: DAB MSN08-13R-CM Rep 3 (Conv)


title: DAB MSN05-01R-CM Rep 3 (Conv)


title: DAS MSN06-07R-CM Rep 4 (Conv)


title: DAB MSN06-07R-CM Rep 3 (Conv)


title: DAB MSN06-07R-CM Rep 2 (Conv)


title: DAB MSN01-03R-CM Rep 4 (Conv)


title: DAB MSN05-01R-CM Rep 2 (Conv)


title: DAB MSN01-03R-CM Rep 1 (Conv)


title: DAB MSN05-01R-CM Rep 1 (Conv)


title: DAB MSN01-03R-CM Rep 2 (Conv)


title: DAB MSN01-03R-CM Rep 3 (Conv)


title: CYC MSN09-04R-CM Rep 3 (Conv)

value: CYC

value: Cyclosporine


title: CYC MSN08-13R-CM Rep 3 (Conv)


title: CYC MSN08-13R-CM Rep 2 (Conv)


title: DAB MSN09-04R-CM Rep 3 (Conv)


title: CYC MSN06-07R-CM Rep 2 (Conv)


title: CYC MSN09-04R-CM Rep 1 (Conv)


title: CYC MSN08-13R-CM Rep 1 (Conv)


title: CYC MSN09-04R-CM Rep 2 (Conv)


title: CYC MSN08-13R-CM Rep 4 (Conv)


title: CYC MSN05-01R-CM Rep 2 (Conv)


title: CYC MSN05-01R-CM Rep 1 (Conv)


title: CYC MSN05-01R-CM Rep 3 (Conv)


title: CYC MSN01-03R-CM Rep 4 (Conv)


title: CYC MSN01-03R-CM Rep 1 (Conv)


title: CTX MSN09-04R-CM Rep 2 (Conv)

value: CTX

value: Cetuximab


title: CTX MSN09-04R-CM Rep 3 (Conv)


title: CTX MSN08-13R-CM Rep 4 (Conv)


title: CTX MSN08-13R-CM Rep 3 (Conv)


title: CYC MSN01-03R-CM Rep 3 (Conv)


title: CTX MSN09-04R-CM Rep 1 (Conv)


title: CTX MSN06-07R-CM Rep 1 (Conv)


title: CTX MSN05-01R-CM Rep 4 (Conv)


title: CTX MSN06-07R-CM Rep 3 (Conv)


title: CTX MSN08-13R-CM Rep 2 (Conv)


title: CTX MSN06-07R-CM Rep 2 (Conv)


title: CYC MSN05-01R-CM Rep 4 (Conv)


title: CYC MSN06-07R-CM Rep 1 (Conv)


title: CTX MSN01-03R-CM Rep 4 (Conv)


title: CTX MSN01-03R-CM Rep 2 (Conv)


title: CTX MSN02-04R-CM Rep 1 (Conv)


title: CTX MSN05-01R-CM Rep 3 (Conv)


title: CTX MSN01-03R-CM Rep 1 (Conv)


title: CTX MSN05-01R-CM Rep 1 (Conv)


title: CTX MSN08-13R-CM Rep 1 (Conv)


title: CTX MSN05-01R-CM Rep 2 (Conv)


title: CTX MSN06-07R-CM Rep 4 (Conv)


title: CTRL MSN09-04R-CM Rep 8 (Conv)

value: CTRL

value: DMSO


title: CTRL MSN09-04R-CM Rep 10 (Conv)


title: CTRL MSN09-04R-CM Rep 11 (Conv)


title: CTRL MSN09-04R-CM Rep 6 (Conv)


title: CTRL MSN09-04R-CM Rep 5 (Conv)


title: CTRL MSN09-04R-CM Rep 4 (Conv)


title: CTRL MSN09-04R-CM Rep 1 (Conv)


title: CTRL MSN08-13R-CM Rep 10 (Conv)


title: CYC MSN01-03R-CM Rep 2 (Conv)


title: CTRL MSN09-04R-CM Rep 3 (Conv)


title: CTRL MSN08-13R-CM Rep 9 (Conv)


title: CTRL MSN08-13R-CM Rep 11 (Conv)


title: CTX MSN01-03R-CM Rep 3 (Conv)


title: CTRL MSN08-13R-CM Rep 6 (Conv)


title: CTRL MSN08-13R-CM Rep 12 (Conv)


title: CTRL MSN09-04R-CM Rep 9 (Conv)


title: CTRL MSN08-13R-CM Rep 7 (Conv)


title: CTRL MSN08-13R-CM Rep 2 (Conv)


title: CTRL MSN08-13R-CM Rep 4 (Conv)


title: CTRL MSN09-04R-CM Rep 7 (Conv)


title: CTRL MSN06-07R-CM Rep 8 (Conv)


title: CTRL MSN08-13R-CM Rep 3 (Conv)


title: CTRL MSN06-07R-CM Rep 9 (Conv)


title: CTRL MSN08-13R-CM Rep 1 (Conv)


title: CTRL MSN06-07R-CM Rep 11 (Conv)


title: CTX MSN02-04R-CM Rep 2 (Conv)


title: CTRL MSN06-07R-CM Rep 7 (Conv)


title: CTRL MSN06-07R-CM Rep 10 (Conv)


title: CTRL MSN08-13R-CM Rep 8 (Conv)


title: CTRL MSN06-07R-CM Rep 6 (Conv)


title: CTRL MSN06-07R-CM Rep 4 (Conv)


title: CTRL MSN05-01R-CM Rep 9 (Conv)


title: CTRL MSN06-07R-CM Rep 3 (Conv)


title: CTRL MSN06-07R-CM Rep 5 (Conv)


title: CTRL MSN06-07R-CM Rep 2 (Conv)


title: CTRL MSN05-01R-CM Rep 2 (Conv)


title: CTRL MSN02-04R-CM Rep 5 (Conv)


title: CTRL MSN05-01R-CM Rep 3 (Conv)


title: CTRL MSN02-04R-CM Rep 2 (Conv)


title: CTRL MSN02-04R-CM Rep 1 (Conv)


title: CTRL MSN05-01R-CM Rep 11 (Conv)


title: CTRL MSN06-07R-CM Rep 1 (Conv)


title: CTRL MSN05-01R-CM Rep 7 (Conv)


title: CTRL MSN01-03R-CM Rep 9 (Conv)


title: CTRL MSN05-01R-CM Rep 6 (Conv)


title: CTRL MSN01-03R-CM Rep 7 (Conv)


title: CTRL MSN05-01R-CM Rep 4 (Conv)


title: CTRL MSN05-01R-CM Rep 10 (Conv)


title: CTRL MSN01-03R-CM Rep 11 (Conv)


title: CTRL MSN05-01R-CM Rep 5 (Conv)


title: CTRL MSN05-01R-CM Rep 1 (Conv)


title: CTRL MSN02-04R-CM Rep 4 (Conv)


title: CTRL MSN01-03R-CM Rep 2 (Conv)


title: CTRL MSN02-04R-CM Rep 3 (Conv)


title: CTRL MSN01-03R-CM Rep 12 (Conv)


title: CRI MSN08-13R-CM Rep 4 (Conv)

value: CRI

value: Crizotinib


title: CTRL MSN05-01R-CM Rep 8 (Conv)


title: CTRL MSN01-03R-CM Rep 5 (Conv)


title: CTRL MSN01-03R-CM Rep 6 (Conv)


title: CTRL MSN01-03R-CM Rep 8 (Conv)


title: CTRL MSN08-13R-CM Rep 5 (Conv)


title: CTRL MSN01-03R-CM Rep 3 (Conv)


title: CTRL MSN05-01R-CM Rep 12 (Conv)


title: CRI MSN08-13R-CM Rep 1 (Conv)


title: CRI MSN08-13R-CM Rep 2 (Conv)


title: CTRL MSN01-03R-CM Rep 10 (Conv)


title: CTRL MSN01-03R-CM Rep 4 (Conv)


title: CRI MSN09-04R-CM Rep 3 (Conv)


title: CTRL MSN01-03R-CM Rep 1 (Conv)


title: CRI MSN05-01R-CM Rep 1 (Conv)


title: CRI MSN06-07R-CM Rep 2 (Conv)


title: CRI MSN09-04R-CM Rep 1 (Conv)


title: CRI MSN06-07R-CM Rep 3 (Conv)


title: CRI MSN09-04R-CM Rep 2 (Conv)


title: CRI MSN08-13R-CM Rep 3 (Conv)


title: CRI MSN05-01R-CM Rep 2 (Conv)


title: CRI MSN05-01R-CM Rep 4 (Conv)


title: CRI MSN06-07R-CM Rep 1 (Conv)


title: CRI MSN06-07R-CM Rep 4 (Conv)


title: CRI MSN05-01R-CM Rep 3 (Conv)


title: CRI MSN01-03R-CM Rep 3 (Conv)


title: CRI MSN01-03R-CM Rep 2 (Conv)


title: CER MSN09-04R-CM Rep 2 (Conv)

value: CER

value: Ceritinib


title: CER MSN08-13R-CM Rep 4 (Conv)


title: CER MSN09-04R-CM Rep 4 (Conv)


title: CER MSN08-13R-CM Rep 2 (Conv)


title: CER MSN08-13R-CM Rep 1 (Conv)


title: CER MSN09-04R-CM Rep 3 (Conv)


title: CER MSN08-13R-CM Rep 3 (Conv)


title: CRI MSN01-03R-CM Rep 1 (Conv)


title: CER MSN06-07R-CM Rep 3 (Conv)


title: CER MSN06-07R-CM Rep 2 (Conv)


title: CER MSN05-01R-CM Rep 4 (Conv)


title: CER MSN06-07R-CM Rep 1 (Conv)


title: CRI MSN01-03R-CM Rep 4 (Conv)


title: CER MSN05-01R-CM Rep 2 (Conv)


title: CER MSN05-01R-CM Rep 3 (Conv)


title: CER MSN01-03R-CM Rep 2 (Conv)


title: CER MSN01-03R-CM Rep 1 (Conv)


title: CAR MSN09-04R-CM Rep 1 (Conv)

value: CAR

value: Carfilzomib


title: CAR MSN09-04R-CM Rep 4 (Conv)

value: skin

value: cardiac myocytes


title: CAR MSN08-13R-CM Rep 3 (Conv)


title: CAR MSN09-04R-CM Rep 3 (Conv)


title: CAR MSN08-13R-CM Rep 2 (Conv)


title: CER MSN09-04R-CM Rep 1 (Conv)


title: CAR MSN08-13R-CM Rep 1 (Conv)


title: CAR MSN08-13R-CM Rep 4 (Conv)


title: CER MSN01-03R-CM Rep 4 (Conv)


title: CAR MSN09-04R-CM Rep 2 (Conv)


title: CAR MSN06-07R-CM Rep 3 (Conv)


title: CAR MSN06-07R-CM Rep 2 (Conv)


title: CER MSN01-03R-CM Rep 3 (Conv)


title: CER MSN05-01R-CM Rep 1 (Conv)


title: CTRL MSN09-04R-CM Rep 2 (Conv)


title: CAR MSN05-01R-CM Rep 4 (Conv)


title: CAR MSN02-04R-CM Rep 4 (Conv)


title: CAR MSN02-04R-CM Rep 3 (Conv)


title: CAR MSN05-01R-CM Rep 2 (Conv)


title: CAR MSN05-01R-CM Rep 1 (Conv)


title: CAR MSN02-04R-CM Rep 2 (Conv)


title: CAR MSN02-04R-CM Rep 1 (Conv)


title: CAR MSN01-03R-CM Rep 4 (Conv)


title: CAR MSN01-03R-CM Rep 3 (Conv)


title: CAR MSN01-03R-CM Rep 2 (Conv)


title: CAB MSN09-04R-CM Rep 4 (Conv)

value: CAB

value: Cabozantinib


title: CAR MSN01-03R-CM Rep 1 (Conv)


title: CAB MSN08-13R-CM Rep 3 (Conv)


title: CAB MSN08-13R-CM Rep 1 (Conv)


title: CAB MSN09-04R-CM Rep 3 (Conv)


title: CAB MSN09-04R-CM Rep 2 (Conv)


title: CAB MSN08-13R-CM Rep 4 (Conv)


title: CAB MSN08-13R-CM Rep 2 (Conv)


title: CAB MSN06-07R-CM Rep 3 (Conv)


title: CAB MSN06-07R-CM Rep 2 (Conv)


title: CAB MSN06-07R-CM Rep 1 (Conv)


title: CAB MSN09-04R-CM Rep 1 (Conv)


title: CAR MSN06-07R-CM Rep 1 (Conv)


title: CAB MSN05-01R-CM Rep 4 (Conv)


title: CAR MSN05-01R-CM Rep 3 (Conv)


title: CAB MSN02-04R-CM Rep 2 (Conv)


title: CAB MSN05-01R-CM Rep 2 (Conv)


title: CAB MSN02-04R-CM Rep 1 (Conv)


title: CAB MSN05-01R-CM Rep 1 (Conv)


title: CAB MSN06-07R-CM Rep 4 (Conv)


title: CAB MSN05-01R-CM Rep 3 (Conv)


title: CAB MSN01-03R-CM Rep 4 (Conv)


title: BOS MSN09-04R-CM Rep 3 (Conv)

value: BOS

value: Bosutinib


title: BOS MSN09-04R-CM Rep 1 (Conv)


title: BOS MSN08-13R-CM Rep 4 (Conv)


title: BOS MSN09-04R-CM Rep 2 (Conv)


title: CAB MSN01-03R-CM Rep 1 (Conv)


title: BOS MSN08-13R-CM Rep 2 (Conv)


title: BOS MSN08-13R-CM Rep 3 (Conv)


title: CAB MSN01-03R-CM Rep 2 (Conv)


title: BOS MSN09-04R-CM Rep 4 (Conv)


title: BOS MSN06-07R-CM Rep 1 (Conv)


title: BOS MSN05-01R-CM Rep 4 (Conv)


title: BOS MSN05-01R-CM Rep 1 (Conv)


title: BOS MSN01-03R-CM Rep 4 (Conv)


title: BOS MSN08-13R-CM Rep 1 (Conv)


title: BOS MSN05-01R-CM Rep 3 (Conv)


title: BOS MSN01-03R-CM Rep 1 (Conv)


title: BOR MSN09-04R-CM Rep 2 (Conv)

value: BOR

value: Bortezomib


title: CAB MSN01-03R-CM Rep 3 (Conv)


title: BOS MSN01-03R-CM Rep 3 (Conv)


title: BOR MSN09-04R-CM Rep 1 (Conv)


title: BOR MSN08-13R-CM Rep 4 (Conv)


title: BOR MSN08-13R-CM Rep 2 (Conv)


title: BOR MSN08-13R-CM Rep 1 (Conv)


title: BOR MSN06-07R-CM Rep 3 (Conv)


title: BOR MSN06-07R-CM Rep 2 (Conv)


title: BOR MSN06-07R-CM Rep 1 (Conv)


title: BOR MSN05-01R-CM Rep 2 (Conv)


title: BOR MSN05-01R-CM Rep 3 (Conv)


title: BOR MSN05-01R-CM Rep 1 (Conv)


title: BOR MSN02-04R-CM Rep 1 (Conv)


title: BOR MSN02-04R-CM Rep 4 (Conv)


title: BOR MSN02-04R-CM Rep 2 (Conv)


title: BOR MSN02-04R-CM Rep 3 (Conv)


title: BOR MSN01-03R-CM Rep 4 (Conv)


title: BOS MSN01-03R-CM Rep 2 (Conv)


title: BOS MSN05-01R-CM Rep 2 (Conv)


title: BOR MSN01-03R-CM Rep 2 (Conv)


title: BEV MSN09-04R-CM Rep 1 (Conv)

value: BEV

value: Bevacizmab


title: BEV MSN09-04R-CM Rep 3 (Conv)


title: BOR MSN08-13R-CM Rep 3 (Conv)


title: BEV MSN08-13R-CM Rep 3 (Conv)


title: BEV MSN09-04R-CM Rep 4 (Conv)


title: BEV MSN08-13R-CM Rep 2 (Conv)


title: BEV MSN06-07R-CM Rep 2 (Conv)


title: BEV MSN05-01R-CM Rep 4 (Conv)


title: BEV MSN06-07R-CM Rep 1 (Conv)


title: BOR MSN05-01R-CM Rep 4 (Conv)


title: BEV MSN05-01R-CM Rep 3 (Conv)


title: BOR MSN01-03R-CM Rep 3 (Conv)


title: BEV MSN01-03R-CM Rep 3 (Conv)


title: AZA MSN09-04R-CM Rep 4 (Conv)

value: AZA

value: Azacytidine


title: AZA MSN09-04R-CM Rep 3 (Conv)


title: AZA MSN09-04R-CM Rep 1 (Conv)


title: BOR MSN01-03R-CM Rep 1 (Conv)


title: BEV MSN01-03R-CM Rep 4 (Conv)


title: AZA MSN08-13R-CM Rep 4 (Conv)


title: AZA MSN08-13R-CM Rep 3 (Conv)


title: BEV MSN01-03R-CM Rep 1 (Conv)


title: BEV MSN08-13R-CM Rep 4 (Conv)


title: BEV MSN09-04R-CM Rep 2 (Conv)


title: AZA MSN08-13R-CM Rep 2 (Conv)


title: AZA MSN06-07R-CM Rep 3 (Conv)


title: AZA MSN08-13R-CM Rep 1 (Conv)


title: AZA MSN06-07R-CM Rep 2 (Conv)


title: AZA MSN06-07R-CM Rep 1 (Conv)


title: AZA MSN05-01R-CM Rep 4 (Conv)


title: BEV MSN06-07R-CM Rep 3 (Conv)


title: AZA MSN05-01R-CM Rep 3 (Conv)


title: BEV MSN08-13R-CM Rep 1 (Conv)


title: AZA MSN05-01R-CM Rep 2 (Conv)


title: AZA MSN02-04R-CM Rep 4 (Conv)


title: AZA MSN02-04R-CM Rep 2 (Conv)