title: Female Spleen, 100 mg/kg/day PFHxSA, Animal r92

description:
Library name: p16_10105_r92_s
etap_pfhxsa_spleen_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: Female Spleen, 30 mg/kg/day PFHxSA, Animal r87

status: Public on Jun 26 2025

type: SRA

city: RTP

first: Logan

middle: J

last: Everett

state: North Carolina

address: 109 T.W. Alexander Dr

department: Office of Research and Development

country: USA

institute: U.S. Environmental Protection Agency

description:
Library name: p16_10105_r87_s
etap_pfhxsa_spleen_female_counts.csv

library_source: transcriptomic

data_processing:
Raw sequencing reads (FASTQ files) were aligned to known probe sequences listed in the TempO-Seq probe manifest using HISAT2 to compute a matrix of read counts for each probe in each sample.
Assembly: TempO-seq Rat S1500+ v1.2
Supplementary files format and content: Count table CSV files contain a row for each known probe and a column for each sample. Each cell contains the number of reads from a single cell uniquely aligned to a single probe sequence
Supplementary files format and content: Probe manifest CSV file contains a row for each known probe with the probe name, sequence, and target gene

molecule: total RNA

organism: Rattus norvegicus

source_name: Spleen

growth_protocol: Male and female Sprague Dawley (Crl:CD IGS, Charles River Laboratory) rats are purchased at 6 – 8 weeks of age. Upon receipt, the animals are placed on a standard, purified laboratory diet and reverse osmosis treated drinking water ad libitum. The specific brand and type of food and source of the water should be noted in Appendix II (Detailed Animal Study Report) of the individual assessment. After a 7- to 14-day quarantine and acclimation period, the animals are weighed and randomly assigned by weight to chemical exposure and control groups. Only clinically healthy animals are used in the study. The target age for initiating exposure is 8 - 10 weeks.

extract_protocol:
Treated and control animals are necropsied approximately 24 hours after the last exposure. Carbon dioxide asphyxiation is used as the method of euthanasia, with death confirmed by a secondary method such as exsanguination or cervical dislocation. The following tissues were dissected from each animal: kidney, liver, adrenal gland, brain, heart, lung, ovary (females), spleen, testis (males), thyroid, thymus, and uterus (females). Tissue samples were collected within ten minutes of termination. The left liver lobe, right kidney, left lung, both testis, uterus, heart, spleen, thymus and whole brain were sectioned into 5mm^3 pieces. Samples from these larger tissues were then individually divided into at least 3 cryovials. At least two of the samples from each tissue in each animal were preserved in RNAlater™ (Thermo Fisher Scientific) at 4°C overnight and then frozen at approximately -20°C for up to 3 weeks before transferring to approximately -80°C. At least one sample from each larger tissue is frozen immediately in liquid nitrogen and stored at approximately -80°C.   The smaller bilateral tissues: adrenal glands, thyroid gland, and ovaries (female) are placed into two cryovials and preserved in RNALater with the left side of the tissue or gland going into the first cryovial and the right side going into the second cryovial. The first tube of RNALater preserved tissue is submitted for sequencing. For each tissue undergoing transcriptomic analysis, total RNA is extracted from one of the aliquots stored in RNAlater™.
The isolated total RNA is used to perform targeted RNA sequencing (RNA-seq) using the BioSpyder TempO-Seq rat S1500+ assay (v1.2) according to manufacturer’s instructions. No specific RNA purity or integrity criteria are applied to the RNA samples as the TempO-Seq assay has been designed to provide high quality gene expression measurements on whole cell lysates, purified RNA, and formalin-fixed paraffin embedded tissue.

treatment_protocol: For oral gavage studies, at least four male and four female rats per dose group receive the vehicle alone or test article in vehicle via gavage (5 or 10 ml/kg) for five days. Animals are weighed daily prior to administration and are observed twice daily, once during administration and once in the late afternoon, at least six hours apart, for assessment of moribundity and mortality. Formal clinical observations are performed on the first day post-dosing and prior to necropsy. Moribund animals or animals exhibiting overt clinical toxicity are removed from the study. The temperature in the experimental animal room is maintained at a target of 22°C (± 3°C) with a relative humidity that is ideally between 50-60% but is at least 30% and preferably not to exceed 70% other than during room cleaning. Lighting is artificial with a sequence of 12 hours light, 12 hours dark. Animals are housed individually or caged in small groups of no more than three animals of the same sex in accordance with local institutional animal care and use requirements.

tag: Sex

value: Female

tag: tissue

value: Spleen

tag: strain

value: Sprague Dawley

tag: age

value: 8-10 weeks

tag: treatment

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

tag: treatment (dose)

value: 30 mg/kg/day

tag: treatment (dose_group)

tag: treatment (chemical_name)

tag: treatment (route_of_exposure)

value: Oral gavage

tag: sample qc_issue

value: No Issue


title: Female Spleen, 100 mg/kg/day PFHxSA, Animal r95

description:
Library name: p16_10105_r95_s
etap_pfhxsa_spleen_female_counts.csv

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: Female Spleen, 10 mg/kg/day PFHxSA, Animal r85

description:
Library name: p16_10105_r85_s
etap_pfhxsa_spleen_female_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: Female Spleen, 100 mg/kg/day PFHxSA, Animal r96

description:
Library name: p16_10105_r96_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 10 mg/kg/day PFHxSA, Animal r86

description:
Library name: p16_10105_r86_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 100 mg/kg/day PFHxSA, Animal r94

description:
Library name: p16_10105_r94_s
etap_pfhxsa_spleen_female_counts.csv

value: Outlier sample removed


title: Female Spleen, 10 mg/kg/day PFHxSA, Animal r83

description:
Library name: p16_10105_r83_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 3 mg/kg/day PFHxSA, Animal r81

description:
Library name: p16_10105_r81_s
etap_pfhxsa_spleen_female_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: Female Spleen, 3 mg/kg/day PFHxSA, Animal r80

description:
Library name: p16_10105_r80_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 10 mg/kg/day PFHxSA, Animal r84

description:
Library name: p16_10105_r84_s
etap_pfhxsa_spleen_female_counts.csv


title: Male Thymus, Vehicle Control, Animal r06

description:
Library name: p17_10105_r06_y
etap_pfhxsa_thymus_male_counts.csv

source_name: Thymus

value: Male

value: Thymus

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: Female Spleen, 3 mg/kg/day PFHxSA, Animal r78

description:
Library name: p16_10105_r78_s
etap_pfhxsa_spleen_female_counts.csv

value: Female

value: Spleen

value: Sprague Dawley

value: Perflurohexanesulfonamide (PFHxSA)


title: Female Spleen, 1 mg/kg/day PFHxSA, Animal r75

description:
Library name: p16_10105_r75_s
etap_pfhxsa_spleen_female_counts.csv

value: 8-10 weeks

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day

value: Oral gavage


title: Female Spleen, 1 mg/kg/day PFHxSA, Animal r76

description:
Library name: p16_10105_r76_s
etap_pfhxsa_spleen_female_counts.csv

value: No Issue


title: Female Spleen, 1 mg/kg/day PFHxSA, Animal r74

description:
Library name: p16_10105_r74_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 3 mg/kg/day PFHxSA, Animal r79

description:
Library name: p16_10105_r79_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 1 mg/kg/day PFHxSA, Animal r72

description:
Library name: p16_10105_r72_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 1 mg/kg/day PFHxSA, Animal r73

description:
Library name: p16_10105_r73_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 3 mg/kg/day PFHxSA, Animal r77

description:
Library name: p16_10105_r77_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.3 mg/kg/day PFHxSA, Animal r70

description:
Library name: p16_10105_r70_s
etap_pfhxsa_spleen_female_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: Female Spleen, 0.3 mg/kg/day PFHxSA, Animal r71

description:
Library name: p16_10105_r71_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.3 mg/kg/day PFHxSA, Animal r69

description:
Library name: p16_10105_r69_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.3 mg/kg/day PFHxSA, Animal r68

description:
Library name: p16_10105_r68_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.3 mg/kg/day PFHxSA, Animal r67

description:
Library name: p16_10105_r67_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.1 mg/kg/day PFHxSA, Animal r63

description:
Library name: p16_10105_r63_s
etap_pfhxsa_spleen_female_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: Female Spleen, 0.01 mg/kg/day PFHxSA, Animal r61

description:
Library name: p16_10105_r61_s
etap_pfhxsa_spleen_female_counts.csv

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: Female Spleen, 0.1 mg/kg/day PFHxSA, Animal r64

description:
Library name: p16_10105_r64_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.01 mg/kg/day PFHxSA, Animal r60

description:
Library name: p16_10105_r60_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 0.01 mg/kg/day PFHxSA, Animal r58

description:
Library name: p16_10105_r58_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, 10 mg/kg/day PFHxSA, Animal r82

description:
Library name: p16_10105_r82_s
etap_pfhxsa_spleen_female_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: Female Spleen, 0.01 mg/kg/day PFHxSA, Animal r59

description:
Library name: p16_10105_r59_s
etap_pfhxsa_spleen_female_counts.csv

value: Female


title: Female Spleen, 0.1 mg/kg/day PFHxSA, Animal r65

description:
Library name: p16_10105_r65_s
etap_pfhxsa_spleen_female_counts.csv

value: Spleen


title: Female Spleen, 0.1 mg/kg/day PFHxSA, Animal r62

description:
Library name: p16_10105_r62_s
etap_pfhxsa_spleen_female_counts.csv

value: Sprague Dawley


title: Female Spleen, Vehicle Control, Animal r55

description:
Library name: p16_10105_r55_s
etap_pfhxsa_spleen_female_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day

value: Perflurohexanesulfonamide (PFHxSA)


title: Female Spleen, Vehicle Control, Animal r54

description:
Library name: p16_10105_r54_s
etap_pfhxsa_spleen_female_counts.csv

value: 8-10 weeks


title: Female Spleen, Vehicle Control, Animal r53

description:
Library name: p16_10105_r53_s
etap_pfhxsa_spleen_female_counts.csv

value: Oral gavage


title: Female Spleen, Vehicle Control, Animal r56

description:
Library name: p16_10105_r56_s
etap_pfhxsa_spleen_female_counts.csv

value: No Issue


title: Female Spleen, 0.01 mg/kg/day PFHxSA, Animal r57

description:
Library name: p16_10105_r57_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, Vehicle Control, Animal r52

description:
Library name: p16_10105_r52_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, Vehicle Control, Animal r51

description:
Library name: p16_10105_r51_s
etap_pfhxsa_spleen_female_counts.csv


title: Female Spleen, Vehicle Control, Animal r50

description:
Library name: p16_10105_r50_s
etap_pfhxsa_spleen_female_counts.csv


title: Male Spleen, 100 mg/kg/day PFHxSA, Animal r48

description:
Library name: p15_10105_r48_s
etap_pfhxsa_spleen_male_counts.csv

value: Male

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: Male Spleen, 100 mg/kg/day PFHxSA, Animal r47

description:
Library name: p15_10105_r47_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 100 mg/kg/day PFHxSA, Animal r46

description:
Library name: p15_10105_r46_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 100 mg/kg/day PFHxSA, Animal r44

description:
Library name: p15_10105_r44_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 100 mg/kg/day PFHxSA, Animal r45

description:
Library name: p15_10105_r45_s
etap_pfhxsa_spleen_male_counts.csv


title: Female Spleen, Vehicle Control, Animal r49

description:
Library name: p16_10105_r49_s
etap_pfhxsa_spleen_female_counts.csv


title: Male Spleen, 30 mg/kg/day PFHxSA, Animal r43

description:
Library name: p15_10105_r43_s
etap_pfhxsa_spleen_male_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: Female Spleen, 0.1 mg/kg/day PFHxSA, Animal r66

description:
Library name: p16_10105_r66_s
etap_pfhxsa_spleen_female_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: Sglib_S3

city: Chicago

first: De

last: Xing

state: IL

address: 264 E Huron St., Suite: 4-121

department: Feinberg School of Medicine, Obstetrics and Gynecology

institute: Northwestern University

description: Library name: Sample8

library_source: genomic

data_processing:
Data were quality checked using FASTQC.
Reads were aligned to a fasta file containing sgRNAs sequences included in the library using the CB2 package.
Data were normalized and analyzed using the CB2 package.
Assembly: GRCh38
Supplementary files format and content: CSV file containing sgRNA and gene statistics.

molecule: genomic DNA

organism: Homo sapiens

source_name: human embryonic kidney

growth_protocol: HEK293T cells were cultured in Dulbecco's Modified Eagle Medium (DMEM, Thermo Fisher Scientific, 11965092) containing 10% Fetal Bovine Serum (Fisher Scientific, SH3091003) and 1% penicillin–streptomycin (Life Technologies,15140–122). The cells were maintained in a humidified incubator at 37 °C.

extract_protocol:
genomic DNA was extracted using the Purelink genomic DNA mini kit (Thermo Fisher, K182002) according to the manufacturer's instructions.
Libraries were constructed using the custom oligos.

value: human embryonic kidney

tag: cell line

tag: cell type

value: Engineered HEK293T cells with OsTIR1_GFP_mAID


title: Sglib_S2

description: Library name: Sample7


title: Male Spleen, 30 mg/kg/day PFHxSA, Animal r41

description:
Library name: p15_10105_r41_s
etap_pfhxsa_spleen_male_counts.csv

value: Spleen


title: Ostir1_S1

description: Library name: Sample2


title: Male Spleen, 30 mg/kg/day PFHxSA, Animal r42

description:
Library name: p15_10105_r42_s
etap_pfhxsa_spleen_male_counts.csv

value: Sprague Dawley


title: Ostir1_P1

description: Library name: Sample1


title: Sglib_S1

description: Library name: Sample6


title: Ostir1_S2

description: Library name: Sample3


title: Ostir1_S3

description: Library name: Sample4


title: Male Spleen, 10 mg/kg/day PFHxSA, Animal r38

description:
Library name: p15_10105_r38_s
etap_pfhxsa_spleen_male_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: Male Spleen, 30 mg/kg/day PFHxSA, Animal r39

description:
Library name: p15_10105_r39_s
etap_pfhxsa_spleen_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Spleen, 30 mg/kg/day PFHxSA, Animal r40

description:
Library name: p15_10105_r40_s
etap_pfhxsa_spleen_male_counts.csv

value: 8-10 weeks


title: Male Spleen, 10 mg/kg/day PFHxSA, Animal r37

description:
Library name: p15_10105_r37_s
etap_pfhxsa_spleen_male_counts.csv

value: Oral gavage


title: SgLib_P1

description: Library name: Sample5


title: HCMVEC, scr shRNA, TGFbeta2

city: Kansas City

first: Eugene

last: Konorev

state: MO

address: 1750 Independence Ave

institute: Kansas City University

description: Library name: Sample 12

data_processing:
PartekFLOW  12.4.3
Pre-alignment QC/QA was performed to assess raw sequencing read quality, and low-quality reads were trimmed using a Phred quality score threshold of >30 with a minimum read length of 25 bp (algorithm is built in PartekFLOW).
Alignment was performed using the STAR 2.7.8a aligner against the human hg38 reference genome and Ensembl transcripts (release 109) index. After alignment, low-quality reads (mapping quality < 20), singletons, and unaligned reads were filtered out.
TGFbeta2 treatment study: Transcripts per kilobase million (TPM) normalization was applied followed by a Poisson regression model with the Wald statistic for p-value calculation. Dox treatment and Dox washout study: protein coding genes were analyzed after median ratio normalization using the DESeq2 method.
Genes meeting the significance threshold of p<0.05 (after Bonferroni correction for multiple testing) with a ≥2-fold change between groups were selected for further analysis.
Assembly: hg 38
Supplementary files format and content: tab delimited text files include raw counts for each sample

source_name: HCMVEC

growth_protocol: Human umbilical vein endothelial cells (HUVEC) and human cardiac microvascular endothelial cells (HCMVEC) were grown in EGM2 and EGM2-MV, respectively, in humidified atmosphere with 5% CO2 at 37C.

extract_protocol:
Total RNA was extracted using mirVana RNA isolation kit and used for construction of the sequencing libraries.
Doxorubicin project: Messenger RNA was purified from total RNA using poly-T oligo-attached magnetic beads. After fragmentation, the first strand cDNA was synthesized using random hexamer primers followed by the second strand cDNA synthesis. The library was ready after end repair, A-tailing, adapter ligation, size selection, amplification, and purification. TGF-beta2 project: cDNA library was constructed using the Illumina TruSeq RNA sample preparation kit.

treatment_protocol: Doxorubicin project: Cells were treated with 16 nM doxorubicin for 48 hours before total RNA extraction (treatment protocol). Additionally, doxorubicin was removed from media to culture cell in doxorubicin free media for 48 hours before total RNA extraction (washout protocol). For the TGF-beta2 study, cells were starved and treated with 0.3 ng/ml TGF-beta2 for 16 hours.

value: HCMVEC

value: endothelial cells

tag: genotype

value: WT (Scrambled shRNA)

value: TGF-beta2 0.3 ng/ml


title: Male Spleen, 10 mg/kg/day PFHxSA, Animal r36

description:
Library name: p15_10105_r36_s
etap_pfhxsa_spleen_male_counts.csv

value: Male

value: No Issue


title: HCMVEC, SMad3 shRNA, TGFbeta2

description: Library name: Sample 14

value: Smad3 knockdown


title: Male Spleen, 10 mg/kg/day PFHxSA, Animal r34

description:
Library name: p15_10105_r34_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 10 mg/kg/day PFHxSA, Animal r35

description:
Library name: p15_10105_r35_s
etap_pfhxsa_spleen_male_counts.csv


title: HCMVEC, scr shRNA, control

description: Library name: Sample 11

value: No treatment


title: HCMVEC, Smad3 shRNA, control

description: Library name: Sample 13


title: Male Spleen, 3 mg/kg/day PFHxSA, Animal r33

description:
Library name: p15_10105_r33_s
etap_pfhxsa_spleen_male_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: Male Spleen, 3 mg/kg/day PFHxSA, Animal r32

description:
Library name: p15_10105_r32_s
etap_pfhxsa_spleen_male_counts.csv

value: Spleen


title: Male Spleen, 3 mg/kg/day PFHxSA, Animal r30

description:
Library name: p15_10105_r30_s
etap_pfhxsa_spleen_male_counts.csv

value: Sprague Dawley


title: 16'-DEC-3

city: Shenzhen

first: haoqiang

last: Wan

address: 1066 Xueyuan Avenue, Nanshan District

country: China

institute: shenzhen university

description: Library name: sample 6

data_processing:
Quality Control: In order to remove technical sequences, including adapters, polymerase chain reaction (PCR) primers, or fragments thereof, and quality of bases lower than 20, pass filter data of fastq format were processed by Cutadapt (V1.9.1, phred cutoff: 20, error rate: 0.1, adapter overlap: 1bp, min. length: 75, proportion of N:0.1) to be high quality clean data.
Alignment: Firstly, reference genome sequences and gene model annotation files of relative species were downloaded from genome website, such as UCSC, NCBI, ENSEMBL. Secondly, Hisat2 (v2.0.1) was used to index reference genome sequence. Finally, clean data were aligned to reference genome via software Hisat2 (v2.0.1).
Expression analysis In the beginning transcripts in fasta format are converted from known gff annotation file and indexed properly. Then, with the file as a reference gene file, HTSeq (v0.6.1) estimated gene and isoform expression levels from the pair-end clean data.
Differential expression analysis Differential expression analysis used the DESeq2 Bioconductor package, a model based on the negative binomial distribution. the estimates of dispersion and logarithmic fold changes incorporate data-driven prior distributions, Padj of genes were setted <0.05 to detect differential expressed ones.
Assembly: Genome: http://ftp.ensembl.org/pub/release-107/fasta/homo_sapiens/dna/Homo_sapiens.GRCh38.dna.primary_assembly.fa.gz
Supplementary files format and content: tab-delimited text file includes raw counts for each sample
Supplementary files format and content: tab-delimited text file includes tpm values for each sample

growth_protocol: Huh7 cells were cultured in DMEM media supplemented with penicillin, streptomycin and 10% fetal bovine serum (FBS) at 37°C in a 5% CO2 incubator.

extract_protocol:
The RNA was extracted using FastPure Total RNA Isolation Kit (Vazyme, Nanjing, China). 1 μg total RNA was used for following library preparation.
The poly(A) mRNA isolation was performed using Oligo(dT) beads. The mRNA fragmentation was performed using divalent cations and high temperature. Priming was performed using Random Primers. First strand cDNA and the second-strand cDNA were synthesized. The purified double-stranded cDNA was then treated to repair both ends and add a dA-tailing in one reaction, followed by a T-A ligation to add adaptors to both ends. Size selection of Adaptor-ligated DNA was then performed using DNA Clean Beads. Each sample was then amplified by PCR using P5 and P7 primers and the PCR products were validated.

treatment_protocol: The cells were seeded 6-well plate for 24 hours, then treated with DMSO or 16'-DEC for 24 hours.

value: WT


title: Male Spleen, 3 mg/kg/day PFHxSA, Animal r31

description:
Library name: p15_10105_r31_s
etap_pfhxsa_spleen_male_counts.csv


title: 16'-DEC-1

description: Library name: sample 4


title: DMSO-3.

description: Library name: sample 3


title: Male Spleen, 3 mg/kg/day PFHxSA, Animal r29

description:
Library name: p15_10105_r29_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 1 mg/kg/day PFHxSA, Animal r28

description:
Library name: p15_10105_r28_s
etap_pfhxsa_spleen_male_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: DMSO-2.

description: Library name: sample 2


title: Male Spleen, 1 mg/kg/day PFHxSA, Animal r27

description:
Library name: p15_10105_r27_s
etap_pfhxsa_spleen_male_counts.csv

value: 8-10 weeks

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Spleen, 1 mg/kg/day PFHxSA, Animal r26

description:
Library name: p15_10105_r26_s
etap_pfhxsa_spleen_male_counts.csv

value: Oral gavage


title: DMSO-1.

description: Library name: sample 1


title: Male Spleen, 1 mg/kg/day PFHxSA, Animal r25

description:
Library name: p15_10105_r25_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 1 mg/kg/day PFHxSA, Animal r24

description:
Library name: p15_10105_r24_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 0.3 mg/kg/day PFHxSA, Animal r23

description:
Library name: p15_10105_r23_s
etap_pfhxsa_spleen_male_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: HUVEC, Dox washout protocol, Dox 2

description: Library name: Sample 9

molecule: polyA RNA

source_name: HUVEC

value: HUVEC

value: endothelial cells

value: Doxorubicin washout


title: Male Spleen, 0.3 mg/kg/day PFHxSA, Animal r21

description:
Library name: p15_10105_r21_s
etap_pfhxsa_spleen_male_counts.csv

value: Male

value: No Issue


title: Male Spleen, 0.3 mg/kg/day PFHxSA, Animal r20

description:
Library name: p15_10105_r20_s
etap_pfhxsa_spleen_male_counts.csv


title: HUVEC, Dox washout protocol, Dox 1

description: Library name: Sample 8


title: Male Spleen, 0.3 mg/kg/day PFHxSA, Animal r19

description:
Library name: p15_10105_r19_s
etap_pfhxsa_spleen_male_counts.csv


title: HUVEC, control  (Input)

description: Library name: Sample 2

data_processing:
Partek Flow (version 12.4.3) analytical software suite by Illumina
FASTQ files generated from ChIP sequencing were aligned by Burrow-Wheeler aligner for longer reads (BWA-MEM) to the human reference genome hg38
After filtering out duplicates, we used the Model-based Analysis of ChIP-seq (MACS) algorithm to identify transcription factor binding sites in control and Dox treated samples
Significant regions were called based on q-value (minimum FDR) set to 0.05. Filtered peaks within the transcriptional start site (TSS) region, with upstream and downstream limits set 2000 and 500 bp, respectively, were annotated according to Ensembl 112 release
We further compared gene counts with identified motifs in the immunoprecipitated Dox and control samples that were normalized using fragments per kilobase per million (FPKM). Poisson regression was used for differential analysis, and only genes with a false discovery rate (FDR) ≤ 0.05 after Benjamini correction for multiple testing were included
Assembly: hg 38
Supplementary files format and content: Text file with -log10(pvalue) and fold enrichment

growth_protocol: Human umbilical vein endothelial cells (HUVEC)  were grown in EGM2 (Lonza) in humidified atmosphere with 5% CO2 at 37C.

extract_protocol:
Cells were fixed with 1% formaldehyde for 10 min. ChIP assay was performed using the SimpleChIP enzymatic chromatin IP kit (Cell Signaling Technology). Chromatin digestion was performed with micrococcal nuclease according to the manufacturer instructions.
DNA library preparation and sequencing were performed by the Novogene Corporation. The DNA fragments were repaired, A-tailed and further ligated with Illumina adapter. The final DNA library was obtained by size selection and PCR amplification.

treatment_protocol: Cells were treated with 16 nM doxorubicin for 48 hours followed by 48-hour washout period before processing cells for the ChIP seq assays.

tag: chip antibody


title: HUVEC, Dox washout protocol, Dox 3

description: Library name: Sample 10


title: HUVEC, Dox washout protocol, control 3

description: Library name: Sample 7

value: No treatment


title: HUVEC, Dox washout (Input)

description: Library name: Sample 4

value: Doxorubicin (16 nM) treatment/washout


title: HUVEC, Dox washout (ChIP)

description: Library name: Sample 3

value: Smad3 (Cell Signaling Technology, #9523)


title: HUVEC, control (ChIP)

description: Library name: Sample 1


title: 16'-DEC-2

description: Library name: sample 5


title: HUVEC, Dox washout protocol, control 2

description: Library name: Sample 6


title: Male Spleen, 0.1 mg/kg/day PFHxSA, Animal r18

description:
Library name: p15_10105_r18_s
etap_pfhxsa_spleen_male_counts.csv

value: Spleen

value: Sprague Dawley

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: HUVEC, Dox washout protocol, control 1

description: Library name: Sample 5

value: WT


title: Male Spleen, 0.1 mg/kg/day PFHxSA, Animal r17

description:
Library name: p15_10105_r17_s
etap_pfhxsa_spleen_male_counts.csv

value: 8-10 weeks

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Spleen, 0.1 mg/kg/day PFHxSA, Animal r16

description:
Library name: p15_10105_r16_s
etap_pfhxsa_spleen_male_counts.csv

value: Oral gavage


title: Male Spleen, 0.1 mg/kg/day PFHxSA, Animal r15

description:
Library name: p15_10105_r15_s
etap_pfhxsa_spleen_male_counts.csv


title: iALL1_28349_chALL2_874415

city: oxford

first: Thomas

last: Jackson

address: weatherall institute of molecular medicine

department: paediatrics

country: United Kingdom

institute: University of Oxford

description:
Library name: iALL1_28349_chALL2_874415
iALL and chALL samples

library_source: transcriptomic single cell

data_processing:
data was aligned using Cell Ranger ARC (v2.0)
ambient RNA was removed using CellBender
Samples were deconvoluted using souporcell (v2.5) and sample identity was assigned by determination of biological sex using the ratio of XIST expression compared to counts for all genes on chrY. Gene expression data was processed using scanpy (v1.10.2). Low quality cells were removed, counts were normalised, and dimensionality reduction (UMAP) was performed following the best practices workflow
Assembly: hg38
Supplementary files format and content: h5ad

source_name: BM

extract_protocol:
Cryopreserved BM cells from the patients were thawed, and 16,000 live CD19+ blasts from each patient sample were FACS-sorted for single nucleus multiome analysis
Cells from 2 patient samples were pooled, and nuclei processed according to manufacturer’s instructions (Chromium 10x: CG000338). Nuclei from 2 pooled samples were loaded on one lane of the Chromium 10x platform. Sequencing was performed by on a NovaSeq 6000, gene expression libraries were sequenced on a PE150 S4 flow cell a

value: BM

value: blast

value: diploid

tag: batch


title: Male Spleen, 0.1 mg/kg/day PFHxSA, Animal r14

description:
Library name: p15_10105_r14_s
etap_pfhxsa_spleen_male_counts.csv


title: Implant, PBS 4

city: Newark

first: Dane

last: Parker

state: NJ

address: 205 South Organge Ave, G-1208

department: Pathology, Immunology and Laboratory Medicine

institute: Rutgers New Jersey Medical School

description: Library name: Human4

data_processing:
Sequencing files were processed in Partek Flow
Assembly: STAR 2.7.8a with hg38 for human
Assembly: STAR 2.7.8a with SA-000013465 for S. aureus
Supplementary files format and content: xls file with normalized counts and expression differences

source_name: Lung

extract_protocol:
Direct-zol micro RNA extraction kit (Zyzmo)
Ribozero plus (Illumina)

value: Lung

value: PBS


title: Implant, PBS 3

description: Library name: Human3


title: Male Spleen, 0.3 mg/kg/day PFHxSA, Animal r22

description:
Library name: p15_10105_r22_s
etap_pfhxsa_spleen_male_counts.csv

value: Male

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day

value: No Issue


title: Male Spleen, 0.01 mg/kg/day PFHxSA, Animal r13

description:
Library name: p15_10105_r13_s
etap_pfhxsa_spleen_male_counts.csv

value: Spleen

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: Implant, PBS 2

description: Library name: Human2


title: Male Spleen, 0.01 mg/kg/day PFHxSA, Animal r12

description:
Library name: p15_10105_r12_s
etap_pfhxsa_spleen_male_counts.csv

value: Sprague Dawley


title: Implant, PBS 1

description: Library name: Human1


title: Male Spleen, 0.01 mg/kg/day PFHxSA, Animal r10

description:
Library name: p15_10105_r10_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 0.01 mg/kg/day PFHxSA, Animal r09

description:
Library name: p15_10105_r09_s
etap_pfhxsa_spleen_male_counts.csv


title: Male Spleen, 0.01 mg/kg/day PFHxSA, Animal r11

description:
Library name: p15_10105_r11_s
etap_pfhxsa_spleen_male_counts.csv


title: organoid, CRISPRa, Cisplatin, CROP-seq

city: Dallas

first: Jin

last: Chen

state: TX

address: 5323 Harry Hines Blvd

institute: UT Southwestern Medical Center

description:
10X Genomics
filtered_feature_bc_matrix.h5
cell_identities.csv
matrix.mtx.gz
features.tsv.gz
barcodes.tsv.gz
CRISPRa_reference_guide_barcode_library.xlsx

data_processing:
Cell Ranger (version 2.1.1, 10X Genomics) with default parameters was used to align reads and generate digital expression matrices from single-cell sequencing data. Cell sgRNA identity assignments were processed using custom Python scripts described previously. Cells with only one assigned sgRNA were retained for further analysis. Custom Python scripts described previously were used to analyze the digital expression matrices, including normalization, quality control, and filtering. To normalize for differences in sequencing capture and coverage across emulsion droplets, we rescaled all cells with the median number of total UMIs.  sgRNAs with lower than 10 cells were removed from the analysis. The expression of each gene was then z-normalized with respect to the mean and standard deviation of that gene in the control population.
Assembly: GRCh38
Supplementary files format and content: 10X Genomics Cellranger output (filtered_feature_bc_matrix.h5)
Supplementary files format and content: sgRNA identities for each cell
Supplementary files format and content: 10X Genomics Cellranger output (matrix.mtx.gz)
Supplementary files format and content: 10X Genomics Cellranger output (features.tsv.gz)
Supplementary files format and content: 10X Genomics Cellranger output (barcodes.tsv.gz)
Supplementary files format and content: sgRNA library sequences and target genes

source_name: Stomach

extract_protocol:
The organoids infected with the sgRNA library were dissociated into single cells, and the live cells were FACS sorted (BD FACS Aria2) to isolate them for single-cell RNA-seq
Cells were prepared for single-cell RNA-seq using the 10X Chromium Controller and Chromium Single Cell 3' Library & Gel Bead Kit v2 (10x Genomics). From the final library, the sgRNA sequences are specifically amplified with PCR, as described before, with the following primers: 5'-AATGATACGGCGACCACCGAGATCTACAC-3' and  5’-CAAGCAGAAGACGGCATACGAGATCAGCCTCGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGgtgttttgagactataaGtatcccttggagaaCCAcctTGTTG-3'. PCR cycling was performed according to the following protocol: (1) 95°C for 3 min, (2) 98°C for 15 s, then 70°C for 10 s (15 cycles) (3) 72 C for 1 min. The resulting sgRNA barcode library was purified via a 0.8X SPRI selection, and then further size was selected using BluePippin (Sage Science). sgRNA barcode libraries were sequenced as spike-ins alongside the parent RNA-seq libraries (5% spike-in) on a NovaSeq 6000, following the manufacturer’s recommendations.

value: Stomach

value: TP53/APC KO Human Gastric Organoids

value: CRISPRa

value: Cisplatin

tag: 10x gem_group


title: Male Spleen, Vehicle Control, Animal r08

description:
Library name: p15_10105_r08_s
etap_pfhxsa_spleen_male_counts.csv

value: 8-10 weeks

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: organoid, CRISPRi, Cisplatin, CROP-seq

description:
10X Genomics
filtered_feature_bc_matrix.h5
cell_identities.csv
matrix.mtx.gz
features.tsv.gz
barcodes.tsv.gz
CRISPRi_reference_guide_barcode_library.xlsx

value: CRISPRi


title: IgG_H9_d8_CUT&RUN_rep2

city: New York

first: Hyein

middle: Sophia

last: Cho

state: NY

address: 430 E 67th St

department: Developmental Biology

institute: Memorial Sloan Kettering Cancer Center

data_processing:
Alignment in bowtie2 v2.5.1
Peak calling in macs2 v2.2.7.1
Peak filtering in IDR v2.0.4.2
Signal normalization factor defined by DESeq2 v1.39
Assembly: hg38
Supplementary files format and content: Signal track in bigWig
Library strategy: CUT&RUN

extract_protocol:
DNA was isolated using an extraction method with phenol and chloroform as described in Skene et al. 2018
Illumina sequencing libraries were prepared using the KAPA HTP Library Preparation Kit

tag: timepoint


title: Male Spleen, Vehicle Control, Animal r05

description:
Library name: p15_10105_r05_s
etap_pfhxsa_spleen_male_counts.csv

tag: Sex

value: Male


title: Male Spleen, Vehicle Control, Animal r06

description:
Library name: p15_10105_r06_s
etap_pfhxsa_spleen_male_counts.csv

tag: tissue


title: H3K27me3_H9_d8_CUT&RUN_rep2


title: iALL2_863388_chALL1_26754

description:
Library name: iALL2_863388_chALL1_26754
iALL and chALL samples

value: BM

value: blast

value: diploid


title: H3K4me3_H9_d8_CUT&RUN_rep2


title: Male Spleen, Vehicle Control, Animal r02

description:
Library name: p15_10105_r02_s
etap_pfhxsa_spleen_male_counts.csv

value: Spleen

tag: strain

value: No Issue


title: organoid, CRISPRi, DMSO, CROP-seq

value: DMSO


title: Male Spleen, Vehicle Control, Animal r07

description:
Library name: p15_10105_r07_s
etap_pfhxsa_spleen_male_counts.csv

value: Sprague Dawley

tag: age


title: Male Spleen, Vehicle Control, Animal r01

description:
Library name: p15_10105_r01_s
etap_pfhxsa_spleen_male_counts.csv

tag: treatment


title: Female Lung, 100 mg/kg/day PFHxSA, Animal r96

description:
Library name: p14_10105_r96_n
etap_pfhxsa_lung_female_counts.csv

value: Female

value: Lung

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

tag: treatment (dose)

value: 100 mg/kg/day


title: Male Spleen, Vehicle Control, Animal r04

description:
Library name: p15_10105_r04_s
etap_pfhxsa_spleen_male_counts.csv

value: 8-10 weeks

value: Corn oil control, 5-day repeat exposure, oral gavage

tag: treatment (dose_group)


title: Male Spleen, Vehicle Control, Animal r03

description:
Library name: p15_10105_r03_s
etap_pfhxsa_spleen_male_counts.csv

value: 0 mg/kg/day

tag: treatment (chemical_name)

value: Perflurohexanesulfonamide (PFHxSA)


title: H3K27me3_H9_d4_CUT&RUN_rep2


title: IgG_H9_d4_CUT&RUN_rep2


title: Female Lung, 100 mg/kg/day PFHxSA, Animal r95

description:
Library name: p14_10105_r95_n
etap_pfhxsa_lung_female_counts.csv

tag: treatment (route_of_exposure)

value: Oral gavage


title: organoid, CRISPRa, DMSO, CROP-seq

value: Stomach

value: TP53/APC KO Human Gastric Organoids

value: CRISPRa


title: Female Lung, 100 mg/kg/day PFHxSA, Animal r94

description:
Library name: p14_10105_r94_n
etap_pfhxsa_lung_female_counts.csv

tag: sample qc_issue


title: H3K27me3_MEN1_d0_CUT&RUN_rep2

tag: cell line

value: MEN1 KO


title: H3K4me3_MEN1_d0_CUT&RUN_rep2


title: Female Lung, 100 mg/kg/day PFHxSA, Animal r93

description:
Library name: p14_10105_r93_n
etap_pfhxsa_lung_female_counts.csv


title: Female Lung, 100 mg/kg/day PFHxSA, Animal r92

description:
Library name: p14_10105_r92_n
etap_pfhxsa_lung_female_counts.csv


title: H3K27me3_H9_d0_CUT&RUN_rep2


title: H3K4me3_H9_d0_CUT&RUN_rep2


title: Female Lung, 30 mg/kg/day PFHxSA, Animal r90

description:
Library name: p14_10105_r90_n
etap_pfhxsa_lung_female_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: H3K4me3_H9_d4_CUT&RUN_rep2


title: H3K27me3_H9_d8_CUT&RUN_rep1


title: Female Lung, 30 mg/kg/day PFHxSA, Animal r91

description:
Library name: p14_10105_r91_n
etap_pfhxsa_lung_female_counts.csv

value: No Issue


title: Female Lung, 30 mg/kg/day PFHxSA, Animal r88

description:
Library name: p14_10105_r88_n
etap_pfhxsa_lung_female_counts.csv

value: Sprague Dawley


title: Female Lung, 30 mg/kg/day PFHxSA, Animal r87

description:
Library name: p14_10105_r87_n
etap_pfhxsa_lung_female_counts.csv

value: Female


title: Female Lung, 30 mg/kg/day PFHxSA, Animal r89

description:
Library name: p14_10105_r89_n
etap_pfhxsa_lung_female_counts.csv

value: Lung


title: IgG_H9_d0_CUT&RUN_rep2


title: IgG_H9_d8_CUT&RUN_rep1


title: Female Lung, 10 mg/kg/day PFHxSA, Animal r86

description:
Library name: p14_10105_r86_n
etap_pfhxsa_lung_female_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: H3K4me3_H9_d4_CUT&RUN_rep1


title: H3K4me3_SUZ12_d0_CUT&RUN_rep2

value: SUZ12 KO


title: H3K27me3_SUZ12_d0_CUT&RUN_rep2


title: Female Lung, 10 mg/kg/day PFHxSA, Animal r85

description:
Library name: p14_10105_r85_n
etap_pfhxsa_lung_female_counts.csv

value: 8-10 weeks


title: IgG_H9_d4_CUT&RUN_rep1


title: Female Lung, 10 mg/kg/day PFHxSA, Animal r83

description:
Library name: p14_10105_r83_n
etap_pfhxsa_lung_female_counts.csv


title: Female Lung, 10 mg/kg/day PFHxSA, Animal r84

description:
Library name: p14_10105_r84_n
etap_pfhxsa_lung_female_counts.csv

value: < 1,200 covered probes


title: H3K27me3_SUZ12_d0_CUT&RUN_rep1


title: Female Lung, 10 mg/kg/day PFHxSA, Animal r82

description:
Library name: p14_10105_r82_n
etap_pfhxsa_lung_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: H3K4me3_SUZ12_d0_CUT&RUN_rep1


title: H3K27me3_MEN1_d0_CUT&RUN_rep1


title: Female Lung, 3 mg/kg/day PFHxSA, Animal r81

description:
Library name: p14_10105_r81_n
etap_pfhxsa_lung_female_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day

value: Oral gavage


title: H3K4me3_MEN1_d0_CUT&RUN_rep1


title: Female Lung, 3 mg/kg/day PFHxSA, Animal r80

description:
Library name: p14_10105_r80_n
etap_pfhxsa_lung_female_counts.csv


title: H3K27me3_H9_d0_CUT&RUN_rep1


title: Female Lung, 3 mg/kg/day PFHxSA, Animal r79

description:
Library name: p14_10105_r79_n
etap_pfhxsa_lung_female_counts.csv


title: H3K4me3_H9_d8_CUT&RUN_rep1


title: H3K4me3_H9_d0_CUT&RUN_rep1


title: Female Lung, 3 mg/kg/day PFHxSA, Animal r78

description:
Library name: p14_10105_r78_n
etap_pfhxsa_lung_female_counts.csv


title: H3K27me3_H9_d4_CUT&RUN_rep1


title: SUZ12_H9_d0_CUT&RUN_rep2


title: MLL1_H9_d0_CUT&RUN_rep2


title: IgG_H9_d0_CUT&RUN_rep1


title: Female Lung, 1 mg/kg/day PFHxSA, Animal r75

description:
Library name: p14_10105_r75_n
etap_pfhxsa_lung_female_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: Female Lung, 1 mg/kg/day PFHxSA, Animal r74

description:
Library name: p14_10105_r74_n
etap_pfhxsa_lung_female_counts.csv


title: Female Lung, 3 mg/kg/day PFHxSA, Animal r77

description:
Library name: p14_10105_r77_n
etap_pfhxsa_lung_female_counts.csv


title: Menin_H9_d0_CUT&RUN_rep2


title: MEN1_d8_set2_RNA-seq_rep3

description:
rep3.MEN1.D8.BAM
counts_RNA_set2.txt

data_processing:
Alignment by Rsubread
Quantification by featureCounts
Differential gene expression by DESeq2
Assembly: hg38
Supplementary files format and content: Tab deliimited text

extract_protocol:
MagMAX mirVana Total RNA Isolation on the KingFisher Flex Magnetic Particle Processor
Illumina TruSeq

value: MEN1 KO


title: Female Lung, 1 mg/kg/day PFHxSA, Animal r73

description:
Library name: p14_10105_r73_n
etap_pfhxsa_lung_female_counts.csv


title: Menin_H9_d0_CUT&RUN_rep1


title: MLL1_H9_d0_CUT&RUN_rep1


title: Female Lung, 1 mg/kg/day PFHxSA, Animal r72

description:
Library name: p14_10105_r72_n
etap_pfhxsa_lung_female_counts.csv


title: Female Lung, 0.3 mg/kg/day PFHxSA, Animal r70

description:
Library name: p14_10105_r70_n
etap_pfhxsa_lung_female_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: SUZ12_H9_d0_CUT&RUN_rep1


title: MEN1_d8_set2_RNA-seq_rep2

description:
rep2.MEN1.D8.BAM
counts_RNA_set2.txt


title: MEN1_d8_set2_RNA-seq_rep1

description:
rep1.MEN1.D8.BAM
counts_RNA_set2.txt


title: Female Lung, 0.3 mg/kg/day PFHxSA, Animal r69

description:
Library name: p14_10105_r69_n
etap_pfhxsa_lung_female_counts.csv

value: Sprague Dawley

value: No Issue


title: NT_d8_set2_RNA-seq_rep3

description:
rep3.NT.D8.BAM
counts_RNA_set2.txt

value: NT


title: Female Lung, 0.3 mg/kg/day PFHxSA, Animal r67

description:
Library name: p14_10105_r67_n
etap_pfhxsa_lung_female_counts.csv

value: Female

value: Lung


title: NT_d8_set2_RNA-seq_rep2

description:
rep2.NT.D8.BAM
counts_RNA_set2.txt


title: Female Lung, 0.1 mg/kg/day PFHxSA, Animal r66

description:
Library name: p14_10105_r66_n
etap_pfhxsa_lung_female_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: NT_d8_set2_RNA-seq_rep1

description:
rep1.NT.D8.BAM
counts_RNA_set2.txt


title: MEN1_d4_set2_RNA-seq_rep3

description:
rep3.MEN1.D4.BAM
counts_RNA_set2.txt


title: Female Lung, 1 mg/kg/day PFHxSA, Animal r76

description:
Library name: p14_10105_r76_n
etap_pfhxsa_lung_female_counts.csv

value: 8-10 weeks

value: < 50% reads aligned


title: Female Lung, 0.1 mg/kg/day PFHxSA, Animal r64

description:
Library name: p14_10105_r64_n
etap_pfhxsa_lung_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: Female Lung, 0.1 mg/kg/day PFHxSA, Animal r63

description:
Library name: p14_10105_r63_n
etap_pfhxsa_lung_female_counts.csv


title: MEN1_d4_set2_RNA-seq_rep1

description:
rep1.MEN1.D4.BAM
counts_RNA_set2.txt


title: NT_d4_set2_RNA-seq_rep2

description:
rep2.NT.D4.BAM
counts_RNA_set2.txt


title: Female Lung, 0.3 mg/kg/day PFHxSA, Animal r71

description:
Library name: p14_10105_r71_n
etap_pfhxsa_lung_female_counts.csv


title: Female Lung, 0.01 mg/kg/day PFHxSA, Animal r59

description:
Library name: p14_10105_r59_n
etap_pfhxsa_lung_female_counts.csv

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: Female Lung, 0.01 mg/kg/day PFHxSA, Animal r61

description:
Library name: p14_10105_r61_n
etap_pfhxsa_lung_female_counts.csv

value: Oral gavage


title: Female Lung, 0.01 mg/kg/day PFHxSA, Animal r60

description:
Library name: p14_10105_r60_n
etap_pfhxsa_lung_female_counts.csv


title: MEN1_d0_set2_RNA-seq_rep2

description:
rep2.MEN1.D0.BAM
counts_RNA_set2.txt


title: Female Lung, Vehicle Control, Animal r56

description:
Library name: p14_10105_r56_n
etap_pfhxsa_lung_female_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: Female Lung, 0.3 mg/kg/day PFHxSA, Animal r68

description:
Library name: p14_10105_r68_n
etap_pfhxsa_lung_female_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage


title: MEN1_d0_set2_RNA-seq_rep3

description:
rep3.MEN1.D0.BAM
counts_RNA_set2.txt

value: MEN1 KO


title: Female Lung, 0.01 mg/kg/day PFHxSA, Animal r57

description:
Library name: p14_10105_r57_n
etap_pfhxsa_lung_female_counts.csv

value: Sprague Dawley


title: MEN1_d0_set2_RNA-seq_rep1

description:
rep1.MEN1.D0.BAM
counts_RNA_set2.txt


title: Female Lung, 0.01 mg/kg/day PFHxSA, Animal r58

description:
Library name: p14_10105_r58_n
etap_pfhxsa_lung_female_counts.csv

value: No Issue


title: NT_d0_set2_RNA-seq_rep3

description:
rep3.NT.D0.BAM
counts_RNA_set2.txt

value: NT


title: Female Lung, Vehicle Control, Animal r55

description:
Library name: p14_10105_r55_n
etap_pfhxsa_lung_female_counts.csv

value: Female


title: Female Lung, Vehicle Control, Animal r54

description:
Library name: p14_10105_r54_n
etap_pfhxsa_lung_female_counts.csv

value: Lung


title: NT_d0_set2_RNA-seq_rep2

description:
rep2.NT.D0.BAM
counts_RNA_set2.txt


title: Female Lung, 0.1 mg/kg/day PFHxSA, Animal r65

description:
Library name: p14_10105_r65_n
etap_pfhxsa_lung_female_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage


title: NT_d0_set2_RNA-seq_rep1

description:
rep1.NT.D0.BAM
counts_RNA_set2.txt


title: Female Lung, Vehicle Control, Animal r53

description:
Library name: p14_10105_r53_n
etap_pfhxsa_lung_female_counts.csv


title: MEN1_d4_set2_RNA-seq_rep2

description:
rep2.MEN1.D4.BAM
counts_RNA_set2.txt


title: Female Lung, 0.1 mg/kg/day PFHxSA, Animal r62

description:
Library name: p14_10105_r62_n
etap_pfhxsa_lung_female_counts.csv

value: 0.1 mg/kg/day


title: SUZ12_d8_set1_RNA-seq_rep3

description:
rep3.SUZ12.D8.BAM
counts_RNA_set1.txt

value: SUZ12 KO


title: SUZ12_d4_set1_RNA-seq_rep3

description:
rep3.SUZ12.D4.BAM
counts_RNA_set1.txt


title: Female Lung, Vehicle Control, Animal r51

description:
Library name: p14_10105_r51_n
etap_pfhxsa_lung_female_counts.csv

value: 8-10 weeks


title: NT_d4_set2_RNA-seq_rep3

description:
rep3.NT.D4.BAM
counts_RNA_set2.txt


title: Female Lung, Vehicle Control, Animal r50

description:
Library name: p14_10105_r50_n
etap_pfhxsa_lung_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: NT_d4_set2_RNA-seq_rep1

description:
rep1.NT.D4.BAM
counts_RNA_set2.txt


title: NT_d10_set1_RNA-seq_rep3

description:
rep3.NT.D10.BAM
counts_RNA_set1.txt


title: SUZ12_d0_set1_RNA-seq_rep3

description:
rep3.SUZ12.D0.BAM
counts_RNA_set1.txt


title: Female Lung, Vehicle Control, Animal r49

description:
Library name: p14_10105_r49_n
etap_pfhxsa_lung_female_counts.csv


title: NT_d9_set1_RNA-seq_rep3

description:
rep3.NT.D9.BAM
counts_RNA_set1.txt


title: Male Lung, 100 mg/kg/day PFHxSA, Animal r46

description:
Library name: p13_10105_r46_n
etap_pfhxsa_lung_male_counts.csv

value: Male

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: Male Lung, 100 mg/kg/day PFHxSA, Animal r47

description:
Library name: p13_10105_r47_n
etap_pfhxsa_lung_male_counts.csv

value: Oral gavage


title: Male Lung, 100 mg/kg/day PFHxSA, Animal r45

description:
Library name: p13_10105_r45_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d4_set1_RNA-seq_rep3

description:
rep3.NT.D4.BAM
counts_RNA_set1.txt


title: Male Lung, 100 mg/kg/day PFHxSA, Animal r44

description:
Library name: p13_10105_r44_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d5_set1_RNA-seq_rep3

description:
rep3.NT.D5.BAM
counts_RNA_set1.txt


title: NT_d3_set1_RNA-seq_rep3

description:
rep3.NT.D3.BAM
counts_RNA_set1.txt


title: Male Lung, 30 mg/kg/day PFHxSA, Animal r43

description:
Library name: p13_10105_r43_n
etap_pfhxsa_lung_male_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: Male Lung, 100 mg/kg/day PFHxSA, Animal r48

description:
Library name: p13_10105_r48_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d2_set1_RNA-seq_rep3

description:
rep3.NT.D2.BAM
counts_RNA_set1.txt


title: NT_d6_set1_RNA-seq_rep3

description:
rep3.NT.D6.BAM
counts_RNA_set1.txt


title: Female Lung, Vehicle Control, Animal r52

description:
Library name: p14_10105_r52_n
etap_pfhxsa_lung_female_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: NT_d8_set1_RNA-seq_rep3

description:
rep3.NT.D8.BAM
counts_RNA_set1.txt


title: Male Lung, 30 mg/kg/day PFHxSA, Animal r41

description:
Library name: p13_10105_r41_n
etap_pfhxsa_lung_male_counts.csv

value: Sprague Dawley

value: No Issue


title: Male Lung, 30 mg/kg/day PFHxSA, Animal r40

description:
Library name: p13_10105_r40_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d0_set1_RNA-seq_rep3

description:
rep3.NT.D0.BAM
counts_RNA_set1.txt

value: NT


title: Male Lung, 30 mg/kg/day PFHxSA, Animal r39

description:
Library name: p13_10105_r39_n
etap_pfhxsa_lung_male_counts.csv

value: Lung


title: Male Lung, 30 mg/kg/day PFHxSA, Animal r42

description:
Library name: p13_10105_r42_n
etap_pfhxsa_lung_male_counts.csv


title: SUZ12_d4_set1_RNA-seq_rep2

description:
rep2.SUZ12.D4.BAM
counts_RNA_set1.txt


title: Male Lung, 10 mg/kg/day PFHxSA, Animal r38

description:
Library name: p13_10105_r38_n
etap_pfhxsa_lung_male_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: Male Lung, 10 mg/kg/day PFHxSA, Animal r37

description:
Library name: p13_10105_r37_n
etap_pfhxsa_lung_male_counts.csv


title: SUZ12_d0_set1_RNA-seq_rep2

description:
rep2.SUZ12.D0.BAM
counts_RNA_set1.txt

value: SUZ12 KO


title: Male Lung, 10 mg/kg/day PFHxSA, Animal r36

description:
Library name: p13_10105_r36_n
etap_pfhxsa_lung_male_counts.csv

value: 8-10 weeks


title: NT_d7_set1_RNA-seq_rep3

description:
rep3.NT.D7.BAM
counts_RNA_set1.txt


title: NT_d10_set1_RNA-seq_rep2

description:
rep2.NT.D10.BAM
counts_RNA_set1.txt


title: NT_d8_set1_RNA-seq_rep2

description:
rep2.NT.D8.BAM
counts_RNA_set1.txt


title: Male Lung, 10 mg/kg/day PFHxSA, Animal r34

description:
Library name: p13_10105_r34_n
etap_pfhxsa_lung_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: NT_d9_set1_RNA-seq_rep2

description:
rep2.NT.D9.BAM
counts_RNA_set1.txt


title: Male Lung, 3 mg/kg/day PFHxSA, Animal r33

description:
Library name: p13_10105_r33_n
etap_pfhxsa_lung_male_counts.csv

value: Male

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: NT_d6_set1_RNA-seq_rep2

description:
rep2.NT.D6.BAM
counts_RNA_set1.txt


title: NT_d5_set1_RNA-seq_rep2

description:
rep2.NT.D5.BAM
counts_RNA_set1.txt


title: NT_d4_set1_RNA-seq_rep2

description:
rep2.NT.D4.BAM
counts_RNA_set1.txt


title: NT_d3_set1_RNA-seq_rep2

description:
rep2.NT.D3.BAM
counts_RNA_set1.txt


title: NT_d1_set1_RNA-seq_rep3

description:
rep3.NT.D1.BAM
counts_RNA_set1.txt


title: Male Lung, 3 mg/kg/day PFHxSA, Animal r29

description:
Library name: p13_10105_r29_n
etap_pfhxsa_lung_male_counts.csv

value: Oral gavage


title: Male Lung, 3 mg/kg/day PFHxSA, Animal r31

description:
Library name: p13_10105_r31_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d2_set1_RNA-seq_rep2

description:
rep2.NT.D2.BAM
counts_RNA_set1.txt


title: NT_d1_set1_RNA-seq_rep2

description:
rep2.NT.D1.BAM
counts_RNA_set1.txt


title: Male Lung, 1 mg/kg/day PFHxSA, Animal r27

description:
Library name: p13_10105_r27_n
etap_pfhxsa_lung_male_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: Male Lung, 3 mg/kg/day PFHxSA, Animal r32

description:
Library name: p13_10105_r32_n
etap_pfhxsa_lung_male_counts.csv


title: Male Lung, 10 mg/kg/day PFHxSA, Animal r35

description:
Library name: p13_10105_r35_n
etap_pfhxsa_lung_male_counts.csv


title: SUZ12_d8_set1_RNA-seq_rep1

description:
rep1.SUZ12.D8.BAM
counts_RNA_set1.txt


title: NT_d0_set1_RNA-seq_rep2

description:
rep2.NT.D0.BAM
counts_RNA_set1.txt


title: Male Lung, 1 mg/kg/day PFHxSA, Animal r24

description:
Library name: p13_10105_r24_n
etap_pfhxsa_lung_male_counts.csv


title: SUZ12_d4_set1_RNA-seq_rep1

description:
rep1.SUZ12.D4.BAM
counts_RNA_set1.txt


title: SUZ12_d0_set1_RNA-seq_rep1

description:
rep1.SUZ12.D0.BAM
counts_RNA_set1.txt


title: Male Lung, 0.3 mg/kg/day PFHxSA, Animal r23

description:
Library name: p13_10105_r23_n
etap_pfhxsa_lung_male_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day

value: Outlier sample removed


title: SUZ12_d8_set1_RNA-seq_rep2

description:
rep2.SUZ12.D8.BAM
counts_RNA_set1.txt


title: Male Lung, 1 mg/kg/day PFHxSA, Animal r28

description:
Library name: p13_10105_r28_n
etap_pfhxsa_lung_male_counts.csv

value: Sprague Dawley

value: No Issue


title: Male Lung, 0.3 mg/kg/day PFHxSA, Animal r22

description:
Library name: p13_10105_r22_n
etap_pfhxsa_lung_male_counts.csv

value: Lung


title: NT_d10_set1_RNA-seq_rep1

description:
rep1.NT.D10.BAM
counts_RNA_set1.txt

value: NT


title: NT_d7_set1_RNA-seq_rep2

description:
rep2.NT.D7.BAM
counts_RNA_set1.txt


title: Male Lung, 3 mg/kg/day PFHxSA, Animal r30

description:
Library name: p13_10105_r30_n
etap_pfhxsa_lung_male_counts.csv


title: Male Lung, 0.3 mg/kg/day PFHxSA, Animal r21

description:
Library name: p13_10105_r21_n
etap_pfhxsa_lung_male_counts.csv


title: Male Lung, 0.3 mg/kg/day PFHxSA, Animal r20

description:
Library name: p13_10105_r20_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d8_set1_RNA-seq_rep1

description:
rep1.NT.D8.BAM
counts_RNA_set1.txt


title: NT_d9_set1_RNA-seq_rep1

description:
rep1.NT.D9.BAM
counts_RNA_set1.txt


title: NT_d7_set1_RNA-seq_rep1

description:
rep1.NT.D7.BAM
counts_RNA_set1.txt


title: Male Lung, 0.1 mg/kg/day PFHxSA, Animal r18

description:
Library name: p13_10105_r18_n
etap_pfhxsa_lung_male_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: NT_d6_set1_RNA-seq_rep1

description:
rep1.NT.D6.BAM
counts_RNA_set1.txt


title: Male Lung, 0.1 mg/kg/day PFHxSA, Animal r16

description:
Library name: p13_10105_r16_n
etap_pfhxsa_lung_male_counts.csv

value: 8-10 weeks


title: Male Lung, 0.1 mg/kg/day PFHxSA, Animal r17

description:
Library name: p13_10105_r17_n
etap_pfhxsa_lung_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: NT_d3_set1_RNA-seq_rep1

description:
rep1.NT.D3.BAM
counts_RNA_set1.txt


title: Male Lung, 0.1 mg/kg/day PFHxSA, Animal r14

description:
Library name: p13_10105_r14_n
etap_pfhxsa_lung_male_counts.csv

value: Male


title: Male Lung, 0.1 mg/kg/day PFHxSA, Animal r15

description:
Library name: p13_10105_r15_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d2_set1_RNA-seq_rep1

description:
rep1.NT.D2.BAM
counts_RNA_set1.txt


title: Male Lung, 0.01 mg/kg/day PFHxSA, Animal r12

description:
Library name: p13_10105_r12_n
etap_pfhxsa_lung_male_counts.csv

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: NT_d1_set1_RNA-seq_rep1

description:
rep1.NT.D1.BAM
counts_RNA_set1.txt


title: Male Lung, 0.01 mg/kg/day PFHxSA, Animal r13

description:
Library name: p13_10105_r13_n
etap_pfhxsa_lung_male_counts.csv

value: Oral gavage


title: Male Lung, 0.01 mg/kg/day PFHxSA, Animal r11

description:
Library name: p13_10105_r11_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d0_set1_RNA-seq_rep1

description:
rep1.NT.D0.BAM
counts_RNA_set1.txt


title: SUZ12_2_d0_ATAC-seq_rep2

data_processing:
Alignment in bowtie2 v2.5.0
Peak calling in macs2 v2.2.7.1
Peak filtering in IDR v2.0.4.2
Differential accessibility analysis in DESeq2 v1.39
Assembly: hg38
Supplementary files format and content: Signal track in bigWig

extract_protocol:
The transposition reaction containing TDE1 Tagment DNA Enzyme was incubated at 37°C for 30 minutes. The DNA was cleaned with the MinElute PCR Purification Kit and material was amplified for 5 cycles using NEBNext High-Fidelity 2X PCR Master Mix.
Illumina Nextera DNA library preparation kit

tag: cell type

value: hESC

value: SUZ12 KO (clone 2)


title: Male Lung, 0.01 mg/kg/day PFHxSA, Animal r10

description:
Library name: p13_10105_r10_n
etap_pfhxsa_lung_male_counts.csv


title: SUZ12_1_d0_ATAC-seq_rep2

tag: genotype

value: SUZ12 KO (clone 1)


title: Male Lung, 1 mg/kg/day PFHxSA, Animal r26

description:
Library name: p13_10105_r26_n
etap_pfhxsa_lung_male_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: MEN1_2_d0_ATAC-seq_rep2

value: MEN1 KO (clone 2)


title: Male Lung, Vehicle Control, Animal r08

description:
Library name: p13_10105_r08_n
etap_pfhxsa_lung_male_counts.csv

value: Sprague Dawley

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day

value: No Issue


title: MEN1_1_d0_ATAC-seq_rep2

value: MEN1 KO (clone 1)


title: Male Lung, 0.3 mg/kg/day PFHxSA, Animal r19

description:
Library name: p13_10105_r19_n
etap_pfhxsa_lung_male_counts.csv

value: Lung

value: 8-10 weeks

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: Male Lung, 0.01 mg/kg/day PFHxSA, Animal r09

description:
Library name: p13_10105_r09_n
etap_pfhxsa_lung_male_counts.csv

value: Male

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Lung, Vehicle Control, Animal r07

description:
Library name: p13_10105_r07_n
etap_pfhxsa_lung_male_counts.csv

value: Oral gavage


title: Male Lung, Vehicle Control, Animal r06

description:
Library name: p13_10105_r06_n
etap_pfhxsa_lung_male_counts.csv


title: NT_d5_set1_RNA-seq_rep1

description:
rep1.NT.D5.BAM
counts_RNA_set1.txt

value: NT


title: SUZ12_2_d0_ATAC-seq_rep1

value: hESC

value: SUZ12 KO (clone 2)


title: SUZ12_1_d0_ATAC-seq_rep1

value: SUZ12 KO (clone 1)


title: NT_d4_set1_RNA-seq_rep1

description:
rep1.NT.D4.BAM
counts_RNA_set1.txt


title: Male Lung, Vehicle Control, Animal r05

description:
Library name: p13_10105_r05_n
etap_pfhxsa_lung_male_counts.csv

value: Sprague Dawley

value: Corn oil control, 5-day repeat exposure, oral gavage


title: MEN1_2_d0_ATAC-seq_rep1

value: MEN1 KO (clone 2)


title: Male Lung, Vehicle Control, Animal r04

description:
Library name: p13_10105_r04_n
etap_pfhxsa_lung_male_counts.csv

value: 0 mg/kg/day

value: No Issue


title: MEN1_1_d0_ATAC-seq_rep1

value: MEN1 KO (clone 1)


title: Male Lung, Vehicle Control, Animal r03

description:
Library name: p13_10105_r03_n
etap_pfhxsa_lung_male_counts.csv

value: Lung

value: 8-10 weeks


title: Male Lung, Vehicle Control, Animal r02

description:
Library name: p13_10105_r02_n
etap_pfhxsa_lung_male_counts.csv

value: Male


title: 2179DNA11

city: San Francisco

first: Charles

last: Langelier

state: CA

address: HSE 401, 513 Parnassus Ave

department: Medicine

institute: University of California San Francisco

data_processing:
Kallisto
Assembly: HG38
Supplementary files format and content: Genecounts table

source_name: Whole blood

extract_protocol:
KingFisher
NEBNext UltraII

value: Whole blood


title: 2186DNA01


title: 2185DNA01


title: Male Lung, Vehicle Control, Animal r01

description:
Library name: p13_10105_r01_n
etap_pfhxsa_lung_male_counts.csv


title: Female Liver, 100 mg/kg/day PFHxSA, Animal r96

description:
Library name: p12_10105_r96_l
etap_pfhxsa_liver_female_counts.csv

source_name: Liver

value: Female

value: Liver

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: 2135DNA01


title: Female Liver, 100 mg/kg/day PFHxSA, Animal r93

description:
Library name: p12_10105_r93_l
etap_pfhxsa_liver_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: Female Liver, 100 mg/kg/day PFHxSA, Animal r94

description:
Library name: p12_10105_r94_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 100 mg/kg/day PFHxSA, Animal r95

description:
Library name: p12_10105_r95_l
etap_pfhxsa_liver_female_counts.csv


title: 2127DNA11


title: NT_d0_ATAC-seq_rep2

value: hESC

value: WT


title: 2132DNA11


title: 2130DNA01


title: Female Liver, 100 mg/kg/day PFHxSA, Animal r92

description:
Library name: p12_10105_r92_l
etap_pfhxsa_liver_female_counts.csv

value: Sprague Dawley


title: 2124DNA01


title: Female Liver, 30 mg/kg/day PFHxSA, Animal r89

description:
Library name: p12_10105_r89_l
etap_pfhxsa_liver_female_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: Female Liver, 30 mg/kg/day PFHxSA, Animal r90

description:
Library name: p12_10105_r90_l
etap_pfhxsa_liver_female_counts.csv

value: No Issue


title: Female Liver, 30 mg/kg/day PFHxSA, Animal r91

description:
Library name: p12_10105_r91_l
etap_pfhxsa_liver_female_counts.csv


title: 2122DNA01


title: 2112DNA11


title: 2106DNA01


title: Female Liver, 30 mg/kg/day PFHxSA, Animal r88

description:
Library name: p12_10105_r88_l
etap_pfhxsa_liver_female_counts.csv


title: NT_d0_ATAC-seq_rep1


title: Female Liver, 10 mg/kg/day PFHxSA, Animal r86

description:
Library name: p12_10105_r86_l
etap_pfhxsa_liver_female_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: Female Liver, 30 mg/kg/day PFHxSA, Animal r87

description:
Library name: p12_10105_r87_l
etap_pfhxsa_liver_female_counts.csv

value: 8-10 weeks


title: Female Liver, 10 mg/kg/day PFHxSA, Animal r85

description:
Library name: p12_10105_r85_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 10 mg/kg/day PFHxSA, Animal r84

description:
Library name: p12_10105_r84_l
etap_pfhxsa_liver_female_counts.csv


title: 2089DNA11


title: 2082DNA11


title: 2059DNA11


title: Female Liver, 10 mg/kg/day PFHxSA, Animal r83

description:
Library name: p12_10105_r83_l
etap_pfhxsa_liver_female_counts.csv

value: < 1,200 covered probes


title: 2016DNA11

value: Whole blood


title: 2001DNA11

value: Male


title: Female Liver, 3 mg/kg/day PFHxSA, Animal r81

description:
Library name: p12_10105_r81_l
etap_pfhxsa_liver_female_counts.csv

value: Female

value: Liver

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: 1961DNA11


title: Female Liver, 3 mg/kg/day PFHxSA, Animal r80

description:
Library name: p12_10105_r80_l
etap_pfhxsa_liver_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: Female Liver, 10 mg/kg/day PFHxSA, Animal r82

description:
Library name: p12_10105_r82_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 3 mg/kg/day PFHxSA, Animal r78

description:
Library name: p12_10105_r78_l
etap_pfhxsa_liver_female_counts.csv


title: 1947DNA11


title: Female Liver, 3 mg/kg/day PFHxSA, Animal r79

description:
Library name: p12_10105_r79_l
etap_pfhxsa_liver_female_counts.csv


title: 1937DNA11


title: 1987DNA11


title: 1936DNA11


title: 2113DNA11


title: Female Liver, 3 mg/kg/day PFHxSA, Animal r77

description:
Library name: p12_10105_r77_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 1 mg/kg/day PFHxSA, Animal r75

description:
Library name: p12_10105_r75_l
etap_pfhxsa_liver_female_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: 1924DNA11


title: Female Liver, 1 mg/kg/day PFHxSA, Animal r76

description:
Library name: p12_10105_r76_l
etap_pfhxsa_liver_female_counts.csv

value: Sprague Dawley


title: Female Liver, 1 mg/kg/day PFHxSA, Animal r74

description:
Library name: p12_10105_r74_l
etap_pfhxsa_liver_female_counts.csv


title: 1909DNA11


title: Female Liver, 1 mg/kg/day PFHxSA, Animal r72

description:
Library name: p12_10105_r72_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 1 mg/kg/day PFHxSA, Animal r73

description:
Library name: p12_10105_r73_l
etap_pfhxsa_liver_female_counts.csv


title: 1892DNA11


title: 1922DNA01


title: 1900DNA11


title: Female Liver, 0.3 mg/kg/day PFHxSA, Animal r71

description:
Library name: p12_10105_r71_l
etap_pfhxsa_liver_female_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: 1886DNA11


title: Female Liver, 0.3 mg/kg/day PFHxSA, Animal r69

description:
Library name: p12_10105_r69_l
etap_pfhxsa_liver_female_counts.csv

value: No Issue


title: 1888DNA11


title: 1885DNA01


title: Female Liver, 0.3 mg/kg/day PFHxSA, Animal r68

description:
Library name: p12_10105_r68_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 0.3 mg/kg/day PFHxSA, Animal r70

description:
Library name: p12_10105_r70_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 0.3 mg/kg/day PFHxSA, Animal r67

description:
Library name: p12_10105_r67_l
etap_pfhxsa_liver_female_counts.csv


title: 1881DNA11


title: 1858DNA11


title: 1872DNA01


title: Female Liver, 0.1 mg/kg/day PFHxSA, Animal r65

description:
Library name: p12_10105_r65_l
etap_pfhxsa_liver_female_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: Female Liver, 0.1 mg/kg/day PFHxSA, Animal r66

description:
Library name: p12_10105_r66_l
etap_pfhxsa_liver_female_counts.csv

value: 8-10 weeks


title: 1860DNA11

value: Whole blood


title: Female Liver, 0.1 mg/kg/day PFHxSA, Animal r63

description:
Library name: p12_10105_r63_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 0.1 mg/kg/day PFHxSA, Animal r64

description:
Library name: p12_10105_r64_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, 0.1 mg/kg/day PFHxSA, Animal r62

description:
Library name: p12_10105_r62_l
etap_pfhxsa_liver_female_counts.csv


title: 1848DNA11


title: 1875DNA01


title: Female Liver, 0.01 mg/kg/day PFHxSA, Animal r60

description:
Library name: p12_10105_r60_l
etap_pfhxsa_liver_female_counts.csv

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: 1841DNA01

value: Female


title: Female Liver, 0.01 mg/kg/day PFHxSA, Animal r58

description:
Library name: p12_10105_r58_l
etap_pfhxsa_liver_female_counts.csv

value: Liver


title: Female Liver, 0.01 mg/kg/day PFHxSA, Animal r59

description:
Library name: p12_10105_r59_l
etap_pfhxsa_liver_female_counts.csv


title: 1829DNA11


title: Female Liver, 0.01 mg/kg/day PFHxSA, Animal r57

description:
Library name: p12_10105_r57_l
etap_pfhxsa_liver_female_counts.csv


title: 1827DNA11


title: Female Liver, 0.01 mg/kg/day PFHxSA, Animal r61

description:
Library name: p12_10105_r61_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, Vehicle Control, Animal r56

description:
Library name: p12_10105_r56_l
etap_pfhxsa_liver_female_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: 1811DNA11


title: 1804DNA11


title: Female Liver, Vehicle Control, Animal r55

description:
Library name: p12_10105_r55_l
etap_pfhxsa_liver_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: 1796DNA11


title: 1857DNA01


title: 1791DNA11


title: Female Liver, Vehicle Control, Animal r53

description:
Library name: p12_10105_r53_l
etap_pfhxsa_liver_female_counts.csv


title: 1785DNA11


title: Female Liver, Vehicle Control, Animal r54

description:
Library name: p12_10105_r54_l
etap_pfhxsa_liver_female_counts.csv


title: 1775DNA11


title: 1844DNA11


title: 1771DNA11


title: Female Liver, Vehicle Control, Animal r50

description:
Library name: p12_10105_r50_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, Vehicle Control, Animal r52

description:
Library name: p12_10105_r52_l
etap_pfhxsa_liver_female_counts.csv


title: Female Liver, Vehicle Control, Animal r49

description:
Library name: p12_10105_r49_l
etap_pfhxsa_liver_female_counts.csv


title: 1768DNA01


title: Male Liver, 100 mg/kg/day PFHxSA, Animal r48

description:
Library name: p11_10105_r48_l
etap_pfhxsa_liver_male_counts.csv

value: Male

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: Female Liver, Vehicle Control, Animal r51

description:
Library name: p12_10105_r51_l
etap_pfhxsa_liver_female_counts.csv

value: Sprague Dawley


title: Male Liver, 100 mg/kg/day PFHxSA, Animal r47

description:
Library name: p11_10105_r47_l
etap_pfhxsa_liver_male_counts.csv

value: No Issue


title: 1766DNA01


title: 1767DNA01


title: Male Liver, 100 mg/kg/day PFHxSA, Animal r46

description:
Library name: p11_10105_r46_l
etap_pfhxsa_liver_male_counts.csv


title: 1763DNA01


title: Male Liver, 100 mg/kg/day PFHxSA, Animal r45

description:
Library name: p11_10105_r45_l
etap_pfhxsa_liver_male_counts.csv


title: 1772DNA11


title: 1760DNA01


title: Male Liver, 30 mg/kg/day PFHxSA, Animal r43

description:
Library name: p11_10105_r43_l
etap_pfhxsa_liver_male_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: Male Liver, 100 mg/kg/day PFHxSA, Animal r44

description:
Library name: p11_10105_r44_l
etap_pfhxsa_liver_male_counts.csv

value: 8-10 weeks


title: Male Lung, 1 mg/kg/day PFHxSA, Animal r25

description:
Library name: p13_10105_r25_n
etap_pfhxsa_lung_male_counts.csv

value: Lung

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: 1762DNA01

value: Whole blood


title: 1757DNA01

value: Female


title: Male Liver, 30 mg/kg/day PFHxSA, Animal r42

description:
Library name: p11_10105_r42_l
etap_pfhxsa_liver_male_counts.csv

value: Liver


title: Male Liver, 30 mg/kg/day PFHxSA, Animal r41

description:
Library name: p11_10105_r41_l
etap_pfhxsa_liver_male_counts.csv


title: 1754DNA01


title: 1751DNA01


title: 1750DNA11


title: Male Liver, 30 mg/kg/day PFHxSA, Animal r39

description:
Library name: p11_10105_r39_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 10 mg/kg/day PFHxSA, Animal r38

description:
Library name: p11_10105_r38_l
etap_pfhxsa_liver_male_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: 1748DNA01


title: Male Liver, 30 mg/kg/day PFHxSA, Animal r40

description:
Library name: p11_10105_r40_l
etap_pfhxsa_liver_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: Male Liver, 10 mg/kg/day PFHxSA, Animal r37

description:
Library name: p11_10105_r37_l
etap_pfhxsa_liver_male_counts.csv

value: Male


title: 1741DNA01


title: 1730DNA01


title: Male Liver, 10 mg/kg/day PFHxSA, Animal r35

description:
Library name: p11_10105_r35_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 10 mg/kg/day PFHxSA, Animal r36

description:
Library name: p11_10105_r36_l
etap_pfhxsa_liver_male_counts.csv


title: 1737DNA11


title: Male Liver, 3 mg/kg/day PFHxSA, Animal r33

description:
Library name: p11_10105_r33_l
etap_pfhxsa_liver_male_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: 1721DNA01


title: 1731DNA11


title: Male Liver, 10 mg/kg/day PFHxSA, Animal r34

description:
Library name: p11_10105_r34_l
etap_pfhxsa_liver_male_counts.csv

value: Sprague Dawley

value: No Issue


title: 1683DNA01


title: 1680DNA01


title: 1682DNA01


title: Male Liver, 3 mg/kg/day PFHxSA, Animal r29

description:
Library name: p11_10105_r29_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 1 mg/kg/day PFHxSA, Animal r28

description:
Library name: p11_10105_r28_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 3 mg/kg/day PFHxSA, Animal r30

description:
Library name: p11_10105_r30_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 1 mg/kg/day PFHxSA, Animal r26

description:
Library name: p11_10105_r26_l
etap_pfhxsa_liver_male_counts.csv


title: 1672DNA01


title: Male Liver, 1 mg/kg/day PFHxSA, Animal r27

description:
Library name: p11_10105_r27_l
etap_pfhxsa_liver_male_counts.csv


title: 1667DNA01


title: 1660DNA01


title: Male Liver, 1 mg/kg/day PFHxSA, Animal r25

description:
Library name: p11_10105_r25_l
etap_pfhxsa_liver_male_counts.csv


title: 1655DNA01


title: 1656DNA01


title: Male Liver, 3 mg/kg/day PFHxSA, Animal r32

description:
Library name: p11_10105_r32_l
etap_pfhxsa_liver_male_counts.csv


title: 1716DNA01


title: Male Liver, 0.3 mg/kg/day PFHxSA, Animal r23

description:
Library name: p11_10105_r23_l
etap_pfhxsa_liver_male_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: Male Liver, 0.3 mg/kg/day PFHxSA, Animal r22

description:
Library name: p11_10105_r22_l
etap_pfhxsa_liver_male_counts.csv

value: 8-10 weeks


title: Male Liver, 3 mg/kg/day PFHxSA, Animal r31

description:
Library name: p11_10105_r31_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 1 mg/kg/day PFHxSA, Animal r24

description:
Library name: p11_10105_r24_l
etap_pfhxsa_liver_male_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage


title: 1647DNA01


title: 1645DNA01


title: 1650DNA01


title: 1641DNA01


title: 1652DNA01


title: Male Liver, 0.3 mg/kg/day PFHxSA, Animal r21

description:
Library name: p11_10105_r21_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, 0.1 mg/kg/day PFHxSA, Animal r18

description:
Library name: p11_10105_r18_l
etap_pfhxsa_liver_male_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: Male Liver, 0.3 mg/kg/day PFHxSA, Animal r19

description:
Library name: p11_10105_r19_l
etap_pfhxsa_liver_male_counts.csv


title: 1669DNA01

value: Whole blood

value: Female


title: 1638DNA01


title: 1633DNA01


title: 1637DNA01


title: Male Liver, 0.1 mg/kg/day PFHxSA, Animal r17

description:
Library name: p11_10105_r17_l
etap_pfhxsa_liver_male_counts.csv

value: Liver


title: Male Liver, 0.1 mg/kg/day PFHxSA, Animal r16

description:
Library name: p11_10105_r16_l
etap_pfhxsa_liver_male_counts.csv


title: 1631DNA01


title: Male Liver, 0.1 mg/kg/day PFHxSA, Animal r15

description:
Library name: p11_10105_r15_l
etap_pfhxsa_liver_male_counts.csv


title: 1623DNA01


title: 1621DNA01


title: Male Liver, 0.01 mg/kg/day PFHxSA, Animal r13

description:
Library name: p11_10105_r13_l
etap_pfhxsa_liver_male_counts.csv

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: 1630DNA01


title: Male Liver, 0.01 mg/kg/day PFHxSA, Animal r11

description:
Library name: p11_10105_r11_l
etap_pfhxsa_liver_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: Male Liver, 0.01 mg/kg/day PFHxSA, Animal r10

description:
Library name: p11_10105_r10_l
etap_pfhxsa_liver_male_counts.csv

value: Male


title: Male Liver, 0.01 mg/kg/day PFHxSA, Animal r12

description:
Library name: p11_10105_r12_l
etap_pfhxsa_liver_male_counts.csv


title: 1614DNA01


title: Male Liver, Vehicle Control, Animal r08

description:
Library name: p11_10105_r08_l
etap_pfhxsa_liver_male_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: 1608DNA01


title: Male Liver, 0.3 mg/kg/day PFHxSA, Animal r20

description:
Library name: p11_10105_r20_l
etap_pfhxsa_liver_male_counts.csv

value: Sprague Dawley

value: No Issue


title: Male Liver, 0.01 mg/kg/day PFHxSA, Animal r09

description:
Library name: p11_10105_r09_l
etap_pfhxsa_liver_male_counts.csv


title: 1597DNA01


title: Male Liver, Vehicle Control, Animal r07

description:
Library name: p11_10105_r07_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, Vehicle Control, Animal r06

description:
Library name: p11_10105_r06_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, Vehicle Control, Animal r05

description:
Library name: p11_10105_r05_l
etap_pfhxsa_liver_male_counts.csv


title: 1596DNA01


title: Male Liver, 0.1 mg/kg/day PFHxSA, Animal r14

description:
Library name: p11_10105_r14_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, Vehicle Control, Animal r04

description:
Library name: p11_10105_r04_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, Vehicle Control, Animal r03

description:
Library name: p11_10105_r03_l
etap_pfhxsa_liver_male_counts.csv


title: Male Liver, Vehicle Control, Animal r01

description:
Library name: p11_10105_r01_l
etap_pfhxsa_liver_male_counts.csv


title: Female Kidney, 100 mg/kg/day PFHxSA, Animal r96

description:
Library name: p10_10105_r96_k
etap_pfhxsa_kidney_female_counts.csv

source_name: Kidney

value: Kidney

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: 1579DNA01


title: Female Kidney, 100 mg/kg/day PFHxSA, Animal r95

description:
Library name: p10_10105_r95_k
etap_pfhxsa_kidney_female_counts.csv

value: 8-10 weeks


title: Male Liver, Vehicle Control, Animal r02

description:
Library name: p11_10105_r02_l
etap_pfhxsa_liver_male_counts.csv


title: 1577DNA11


title: 1575DNA01


title: 1571DNA11


title: 1602DNA01


title: Female Kidney, 100 mg/kg/day PFHxSA, Animal r93

description:
Library name: p10_10105_r93_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 100 mg/kg/day PFHxSA, Animal r92

description:
Library name: p10_10105_r92_k
etap_pfhxsa_kidney_female_counts.csv


title: 1569DNA01


title: Female Kidney, 30 mg/kg/day PFHxSA, Animal r91

description:
Library name: p10_10105_r91_k
etap_pfhxsa_kidney_female_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: 1551DNA01

value: Whole blood

value: Female


title: Female Kidney, 30 mg/kg/day PFHxSA, Animal r90

description:
Library name: p10_10105_r90_k
etap_pfhxsa_kidney_female_counts.csv


title: 1586DNA01


title: Female Kidney, 30 mg/kg/day PFHxSA, Animal r87

description:
Library name: p10_10105_r87_k
etap_pfhxsa_kidney_female_counts.csv


title: 1567DNA01


title: Female Kidney, 30 mg/kg/day PFHxSA, Animal r89

description:
Library name: p10_10105_r89_k
etap_pfhxsa_kidney_female_counts.csv


title: 1558DNA01


title: 1549DNA11


title: Female Kidney, 10 mg/kg/day PFHxSA, Animal r86

description:
Library name: p10_10105_r86_k
etap_pfhxsa_kidney_female_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: 1543DNA11


title: 1539DNA01


title: Female Kidney, 10 mg/kg/day PFHxSA, Animal r85

description:
Library name: p10_10105_r85_k
etap_pfhxsa_kidney_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: 1576DNA11


title: Female Kidney, 100 mg/kg/day PFHxSA, Animal r94

description:
Library name: p10_10105_r94_k
etap_pfhxsa_kidney_female_counts.csv

value: Oral gavage


title: 1538DNA01


title: 1615DNA01

value: Male


title: Female Kidney, 10 mg/kg/day PFHxSA, Animal r84

description:
Library name: p10_10105_r84_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 10 mg/kg/day PFHxSA, Animal r83

description:
Library name: p10_10105_r83_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 10 mg/kg/day PFHxSA, Animal r82

description:
Library name: p10_10105_r82_k
etap_pfhxsa_kidney_female_counts.csv


title: 1533DNA01


title: 1530DNA01


title: 1523DNA01


title: Female Kidney, 3 mg/kg/day PFHxSA, Animal r81

description:
Library name: p10_10105_r81_k
etap_pfhxsa_kidney_female_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: 1522DNA01


title: Female Kidney, 30 mg/kg/day PFHxSA, Animal r88

description:
Library name: p10_10105_r88_k
etap_pfhxsa_kidney_female_counts.csv

value: Sprague Dawley


title: Female Kidney, 3 mg/kg/day PFHxSA, Animal r79

description:
Library name: p10_10105_r79_k
etap_pfhxsa_kidney_female_counts.csv

value: No Issue


title: 1520DNA01


title: Female Kidney, 1 mg/kg/day PFHxSA, Animal r76

description:
Library name: p10_10105_r76_k
etap_pfhxsa_kidney_female_counts.csv

value: Kidney

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: Female Kidney, 3 mg/kg/day PFHxSA, Animal r77

description:
Library name: p10_10105_r77_k
etap_pfhxsa_kidney_female_counts.csv

value: 8-10 weeks


title: Female Kidney, 3 mg/kg/day PFHxSA, Animal r78

description:
Library name: p10_10105_r78_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 1 mg/kg/day PFHxSA, Animal r75

description:
Library name: p10_10105_r75_k
etap_pfhxsa_kidney_female_counts.csv


title: 1513DNA01


title: 1511DNA01


title: Female Kidney, 1 mg/kg/day PFHxSA, Animal r74

description:
Library name: p10_10105_r74_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 1 mg/kg/day PFHxSA, Animal r73

description:
Library name: p10_10105_r73_k
etap_pfhxsa_kidney_female_counts.csv


title: 1510DNA01


title: Female Kidney, 1 mg/kg/day PFHxSA, Animal r72

description:
Library name: p10_10105_r72_k
etap_pfhxsa_kidney_female_counts.csv


title: 1598DNA01


title: 1535DNA01


title: 1493DNA01


title: Female Kidney, 0.3 mg/kg/day PFHxSA, Animal r70

description:
Library name: p10_10105_r70_k
etap_pfhxsa_kidney_female_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: 1492DNA01

value: Whole blood


title: 1580DNA01

value: Female


title: Female Kidney, 3 mg/kg/day PFHxSA, Animal r80

description:
Library name: p10_10105_r80_k
etap_pfhxsa_kidney_female_counts.csv


title: 1582DNA01


title: 1488DNA01


title: Female Kidney, 0.3 mg/kg/day PFHxSA, Animal r69

description:
Library name: p10_10105_r69_k
etap_pfhxsa_kidney_female_counts.csv


title: 1479DNA01


title: 1519DNA01


title: 1480DNA01


title: Female Kidney, 0.1 mg/kg/day PFHxSA, Animal r66

description:
Library name: p10_10105_r66_k
etap_pfhxsa_kidney_female_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: Female Kidney, 0.3 mg/kg/day PFHxSA, Animal r67

description:
Library name: p10_10105_r67_k
etap_pfhxsa_kidney_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: 1472DNA01


title: Female Kidney, 0.1 mg/kg/day PFHxSA, Animal r64

description:
Library name: p10_10105_r64_k
etap_pfhxsa_kidney_female_counts.csv

value: Oral gavage


title: 1453DNA01


title: 1445DNA01


title: 1496DNA01


title: Female Kidney, 0.1 mg/kg/day PFHxSA, Animal r62

description:
Library name: p10_10105_r62_k
etap_pfhxsa_kidney_female_counts.csv


title: 1442DNA01


title: Female Kidney, 0.01 mg/kg/day PFHxSA, Animal r61

description:
Library name: p10_10105_r61_k
etap_pfhxsa_kidney_female_counts.csv

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: 1452DNA11


title: Female Kidney, 0.01 mg/kg/day PFHxSA, Animal r60

description:
Library name: p10_10105_r60_k
etap_pfhxsa_kidney_female_counts.csv


title: 1426DNA01


title: Female Kidney, 0.01 mg/kg/day PFHxSA, Animal r58

description:
Library name: p10_10105_r58_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 0.3 mg/kg/day PFHxSA, Animal r68

description:
Library name: p10_10105_r68_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 0.01 mg/kg/day PFHxSA, Animal r57

description:
Library name: p10_10105_r57_k
etap_pfhxsa_kidney_female_counts.csv


title: 1425DNA01


title: 1424DNA01


title: Female Kidney, Vehicle Control, Animal r56

description:
Library name: p10_10105_r56_k
etap_pfhxsa_kidney_female_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: 1420DNA01


title: 1421DNA01


title: 1514DNA01


title: 1418DNA11


title: Female Kidney, Vehicle Control, Animal r54

description:
Library name: p10_10105_r54_k
etap_pfhxsa_kidney_female_counts.csv

value: Sprague Dawley

value: No Issue


title: Female Kidney, 0.1 mg/kg/day PFHxSA, Animal r65

description:
Library name: p10_10105_r65_k
etap_pfhxsa_kidney_female_counts.csv

value: Kidney


title: 1456DNA01


title: Female Kidney, 0.1 mg/kg/day PFHxSA, Animal r63

description:
Library name: p10_10105_r63_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, Vehicle Control, Animal r55

description:
Library name: p10_10105_r55_k
etap_pfhxsa_kidney_female_counts.csv


title: 1414DNA01

value: Male


title: 1419DNA11


title: Female Kidney, Vehicle Control, Animal r52

description:
Library name: p10_10105_r52_k
etap_pfhxsa_kidney_female_counts.csv

value: 8-10 weeks


title: 1407DNA01


title: Female Kidney, Vehicle Control, Animal r51

description:
Library name: p10_10105_r51_k
etap_pfhxsa_kidney_female_counts.csv


title: 1417DNA01


title: Female Kidney, Vehicle Control, Animal r50

description:
Library name: p10_10105_r50_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, 0.01 mg/kg/day PFHxSA, Animal r59

description:
Library name: p10_10105_r59_k
etap_pfhxsa_kidney_female_counts.csv


title: Female Kidney, Vehicle Control, Animal r49

description:
Library name: p10_10105_r49_k
etap_pfhxsa_kidney_female_counts.csv


title: Male Kidney, 100 mg/kg/day PFHxSA, Animal r48

description:
Library name: p09_10105_r48_k
etap_pfhxsa_kidney_male_counts.csv

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: 1400DNA01

value: Whole blood


title: 1396DNA01

value: Female


title: 1406DNA01


title: 1389DNA01


title: Male Kidney, 100 mg/kg/day PFHxSA, Animal r47

description:
Library name: p09_10105_r47_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 100 mg/kg/day PFHxSA, Animal r46

description:
Library name: p09_10105_r46_k
etap_pfhxsa_kidney_male_counts.csv


title: 1386DNA01


title: Female Kidney, Vehicle Control, Animal r53

description:
Library name: p10_10105_r53_k
etap_pfhxsa_kidney_female_counts.csv


title: Male Kidney, 100 mg/kg/day PFHxSA, Animal r44

description:
Library name: p09_10105_r44_k
etap_pfhxsa_kidney_male_counts.csv


title: 1381DNA01


title: 1368DNA01


title: Male Kidney, 30 mg/kg/day PFHxSA, Animal r43

description:
Library name: p09_10105_r43_k
etap_pfhxsa_kidney_male_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: 1366DNA01


title: Male Kidney, 30 mg/kg/day PFHxSA, Animal r42

description:
Library name: p09_10105_r42_k
etap_pfhxsa_kidney_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Kidney, 30 mg/kg/day PFHxSA, Animal r41

description:
Library name: p09_10105_r41_k
etap_pfhxsa_kidney_male_counts.csv

value: Oral gavage


title: Male Kidney, 30 mg/kg/day PFHxSA, Animal r39

description:
Library name: p09_10105_r39_k
etap_pfhxsa_kidney_male_counts.csv


title: Female Kidney, 0.3 mg/kg/day PFHxSA, Animal r71

description:
Library name: p10_10105_r71_k
etap_pfhxsa_kidney_female_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.3 mg/kg/day


title: 1404DNA01


title: 1343DNA01


title: 1345DNA01


title: 1340DNA01


title: Male Kidney, 30 mg/kg/day PFHxSA, Animal r40

description:
Library name: p09_10105_r40_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 10 mg/kg/day PFHxSA, Animal r38

description:
Library name: p09_10105_r38_k
etap_pfhxsa_kidney_male_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: 1338DNA01


title: Male Kidney, 10 mg/kg/day PFHxSA, Animal r36

description:
Library name: p09_10105_r36_k
etap_pfhxsa_kidney_male_counts.csv

value: Sprague Dawley


title: Male Kidney, 10 mg/kg/day PFHxSA, Animal r37

description:
Library name: p09_10105_r37_k
etap_pfhxsa_kidney_male_counts.csv

value: No Issue


title: 1337DNA01


title: Male Kidney, 10 mg/kg/day PFHxSA, Animal r35

description:
Library name: p09_10105_r35_k
etap_pfhxsa_kidney_male_counts.csv

value: Kidney


title: Male Kidney, 100 mg/kg/day PFHxSA, Animal r45

description:
Library name: p09_10105_r45_k
etap_pfhxsa_kidney_male_counts.csv

value: Male


title: 1334DNA01


title: 1333DNA01


title: Male Kidney, 10 mg/kg/day PFHxSA, Animal r34

description:
Library name: p09_10105_r34_k
etap_pfhxsa_kidney_male_counts.csv

value: 8-10 weeks


title: Male Kidney, 3 mg/kg/day PFHxSA, Animal r32

description:
Library name: p09_10105_r32_k
etap_pfhxsa_kidney_male_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: Male Kidney, 3 mg/kg/day PFHxSA, Animal r33

description:
Library name: p09_10105_r33_k
etap_pfhxsa_kidney_male_counts.csv


title: 1332DNA01

value: Whole blood


title: 1329DNA01

value: Female


title: Male Kidney, 3 mg/kg/day PFHxSA, Animal r31

description:
Library name: p09_10105_r31_k
etap_pfhxsa_kidney_male_counts.csv


title: 1328DNA01


title: 1350DNA01


title: 1326DNA01


title: Male Kidney, 3 mg/kg/day PFHxSA, Animal r29

description:
Library name: p09_10105_r29_k
etap_pfhxsa_kidney_male_counts.csv


title: 1325DNA01


title: 1341DNA01


title: Male Kidney, 1 mg/kg/day PFHxSA, Animal r27

description:
Library name: p09_10105_r27_k
etap_pfhxsa_kidney_male_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day


title: 1322DNA01


title: 1324DNA01


title: Male Kidney, 1 mg/kg/day PFHxSA, Animal r28

description:
Library name: p09_10105_r28_k
etap_pfhxsa_kidney_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Kidney, 1 mg/kg/day PFHxSA, Animal r26

description:
Library name: p09_10105_r26_k
etap_pfhxsa_kidney_male_counts.csv

value: Oral gavage


title: 1321DNA01


title: 1320DNA01


title: Male Kidney, 1 mg/kg/day PFHxSA, Animal r24

description:
Library name: p09_10105_r24_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 0.3 mg/kg/day PFHxSA, Animal r23

description:
Library name: p09_10105_r23_k
etap_pfhxsa_kidney_male_counts.csv

value: 0.3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage


title: Male Kidney, 1 mg/kg/day PFHxSA, Animal r25

description:
Library name: p09_10105_r25_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 0.3 mg/kg/day PFHxSA, Animal r22

description:
Library name: p09_10105_r22_k
etap_pfhxsa_kidney_male_counts.csv

value: 0.3 mg/kg/day


title: 1319DNA01


title: 1315DNA01


title: 1318DNA01


title: Male Kidney, 0.3 mg/kg/day PFHxSA, Animal r21

description:
Library name: p09_10105_r21_k
etap_pfhxsa_kidney_male_counts.csv


title: 1313DNA01


title: Male Kidney, 0.3 mg/kg/day PFHxSA, Animal r20

description:
Library name: p09_10105_r20_k
etap_pfhxsa_kidney_male_counts.csv


title: 1311DNA01


title: Male Kidney, 0.3 mg/kg/day PFHxSA, Animal r19

description:
Library name: p09_10105_r19_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 0.1 mg/kg/day PFHxSA, Animal r18

description:
Library name: p09_10105_r18_k
etap_pfhxsa_kidney_male_counts.csv

value: 0.1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.1 mg/kg/day


title: Male Kidney, 3 mg/kg/day PFHxSA, Animal r30

description:
Library name: p09_10105_r30_k
etap_pfhxsa_kidney_male_counts.csv

value: Sprague Dawley


title: 1310DNA01


title: 1301DNA01


title: Male Kidney, 0.1 mg/kg/day PFHxSA, Animal r17

description:
Library name: p09_10105_r17_k
etap_pfhxsa_kidney_male_counts.csv

value: No Issue


title: Male Kidney, 0.1 mg/kg/day PFHxSA, Animal r16

description:
Library name: p09_10105_r16_k
etap_pfhxsa_kidney_male_counts.csv

value: Kidney


title: 1297DNA01


title: Male Kidney, 0.1 mg/kg/day PFHxSA, Animal r15

description:
Library name: p09_10105_r15_k
etap_pfhxsa_kidney_male_counts.csv

value: Male


title: 1286DNA01


title: Male Kidney, 0.01 mg/kg/day PFHxSA, Animal r13

description:
Library name: p09_10105_r13_k
etap_pfhxsa_kidney_male_counts.csv

value: 8-10 weeks

value: 0.01 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 0.01 mg/kg/day


title: Male Kidney, 0.1 mg/kg/day PFHxSA, Animal r14

description:
Library name: p09_10105_r14_k
etap_pfhxsa_kidney_male_counts.csv


title: 1285DNA01

value: Whole blood


title: 1282DNA01

value: Female


title: 1279DNA01


title: Male Kidney, 0.01 mg/kg/day PFHxSA, Animal r12

description:
Library name: p09_10105_r12_k
etap_pfhxsa_kidney_male_counts.csv


title: 1263DNA01


title: 1270DNA01


title: Male Kidney, 0.01 mg/kg/day PFHxSA, Animal r09

description:
Library name: p09_10105_r09_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 0.01 mg/kg/day PFHxSA, Animal r10

description:
Library name: p09_10105_r10_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, 0.01 mg/kg/day PFHxSA, Animal r11

description:
Library name: p09_10105_r11_k
etap_pfhxsa_kidney_male_counts.csv


title: 1259DNA01


title: 1258DNA01


title: 1262DNA01


title: 1256DNA01


title: Male Kidney, Vehicle Control, Animal r08

description:
Library name: p09_10105_r08_k
etap_pfhxsa_kidney_male_counts.csv

value: Corn oil control, 5-day repeat exposure, oral gavage

value: 0 mg/kg/day


title: Male Kidney, Vehicle Control, Animal r06

description:
Library name: p09_10105_r06_k
etap_pfhxsa_kidney_male_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)


title: Male Kidney, Vehicle Control, Animal r04

description:
Library name: p09_10105_r04_k
etap_pfhxsa_kidney_male_counts.csv

value: Oral gavage


title: 1251DNA01


title: Male Kidney, Vehicle Control, Animal r05

description:
Library name: p09_10105_r05_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, Vehicle Control, Animal r02

description:
Library name: p09_10105_r02_k
etap_pfhxsa_kidney_male_counts.csv


title: 1248DNA01


title: Male Kidney, Vehicle Control, Animal r03

description:
Library name: p09_10105_r03_k
etap_pfhxsa_kidney_male_counts.csv


title: Male Kidney, Vehicle Control, Animal r01

description:
Library name: p09_10105_r01_k
etap_pfhxsa_kidney_male_counts.csv


title: 1294DNA01


title: Female Heart, 100 mg/kg/day PFHxSA, Animal r96

description:
Library name: p06_10105_r96_h
etap_pfhxsa_heart_female_counts.csv

source_name: Heart

value: Heart

value: 100 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 100 mg/kg/day


title: 1244DNA01


title: Female Heart, 100 mg/kg/day PFHxSA, Animal r95

description:
Library name: p06_10105_r95_h
etap_pfhxsa_heart_female_counts.csv


title: Female Heart, 100 mg/kg/day PFHxSA, Animal r94

description:
Library name: p06_10105_r94_h
etap_pfhxsa_heart_female_counts.csv


title: Female Heart, 100 mg/kg/day PFHxSA, Animal r93

description:
Library name: p06_10105_r93_h
etap_pfhxsa_heart_female_counts.csv


title: 1238DNA11


title: 1240DNA01


title: 1243DNA01


title: 1226DNA01


title: Female Heart, 30 mg/kg/day PFHxSA, Animal r91

description:
Library name: p06_10105_r91_h
etap_pfhxsa_heart_female_counts.csv

value: 30 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 30 mg/kg/day


title: Female Heart, 30 mg/kg/day PFHxSA, Animal r90

description:
Library name: p06_10105_r90_h
etap_pfhxsa_heart_female_counts.csv

value: Sprague Dawley

value: No Issue


title: 1225DNA01


title: 1250DNA01


title: 1249DNA01


title: 1219DNA01


title: Male Kidney, Vehicle Control, Animal r07

description:
Library name: p09_10105_r07_k
etap_pfhxsa_kidney_male_counts.csv

value: Male

value: Kidney


title: Female Heart, 30 mg/kg/day PFHxSA, Animal r89

description:
Library name: p06_10105_r89_h
etap_pfhxsa_heart_female_counts.csv

value: 8-10 weeks


title: 1221DNA01


title: Female Heart, 30 mg/kg/day PFHxSA, Animal r88

description:
Library name: p06_10105_r88_h
etap_pfhxsa_heart_female_counts.csv


title: 1234DNA01


title: 1216DNA01


title: 1217DNA01


title: 1208DNA01


title: Female Heart, 100 mg/kg/day PFHxSA, Animal r92

description:
Library name: p06_10105_r92_h
etap_pfhxsa_heart_female_counts.csv


title: 1203DNA01


title: Female Heart, 10 mg/kg/day PFHxSA, Animal r84

description:
Library name: p06_10105_r84_h
etap_pfhxsa_heart_female_counts.csv

value: 10 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 10 mg/kg/day


title: Female Heart, 10 mg/kg/day PFHxSA, Animal r83

description:
Library name: p06_10105_r83_h
etap_pfhxsa_heart_female_counts.csv

value: Female


title: Female Heart, 10 mg/kg/day PFHxSA, Animal r85

description:
Library name: p06_10105_r85_h
etap_pfhxsa_heart_female_counts.csv


title: 1198DNA01

value: Whole blood


title: 1197DNA01


title: Female Heart, 10 mg/kg/day PFHxSA, Animal r82

description:
Library name: p06_10105_r82_h
etap_pfhxsa_heart_female_counts.csv


title: Female Heart, 3 mg/kg/day PFHxSA, Animal r81

description:
Library name: p06_10105_r81_h
etap_pfhxsa_heart_female_counts.csv

value: 3 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 3 mg/kg/day


title: 1196DNA01


title: 1195DNA01


title: 1193DNA01


title: Female Heart, 3 mg/kg/day PFHxSA, Animal r80

description:
Library name: p06_10105_r80_h
etap_pfhxsa_heart_female_counts.csv

value: Perflurohexanesulfonamide (PFHxSA)

value: Oral gavage


title: Female Heart, 3 mg/kg/day PFHxSA, Animal r79

description:
Library name: p06_10105_r79_h
etap_pfhxsa_heart_female_counts.csv

value: Heart


title: Female Heart, 30 mg/kg/day PFHxSA, Animal r87

description:
Library name: p06_10105_r87_h
etap_pfhxsa_heart_female_counts.csv


title: Female Heart, 10 mg/kg/day PFHxSA, Animal r86

description:
Library name: p06_10105_r86_h
etap_pfhxsa_heart_female_counts.csv


title: Female Heart, 3 mg/kg/day PFHxSA, Animal r78

description:
Library name: p06_10105_r78_h
etap_pfhxsa_heart_female_counts.csv


title: 1165DNA01


title: Female Heart, 1 mg/kg/day PFHxSA, Animal r76

description:
Library name: p06_10105_r76_h
etap_pfhxsa_heart_female_counts.csv

value: 1 mg/kg/day PFHxSA, 5-day repeat exposure, oral gavage

value: 1 mg/kg/day