title: SuperArray GEArray Q series Mouse G Protein-coupled Receptors Signaling PathwayFinder Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Mus musculus
description: GEArray Q series Mouse G Protein-coupled Receptors Signaling PathwayFinder Gene Array is designed to help you to navigating through the pathways activated by G protein-coupled receptors (GPCR). GPCRs constitute the largest family of cell surface molecules involved in signal transmission. These receptors are activated by a wide variety of ligands, including peptide and non-peptide neurotransmitters, hormones, growth factors, odorant molecules and light. These receptors are the target of >50% of the current therapeutic agents on the market, including more than a quarter of the 100 top-selling drugs. Recent studies demonstrated that cellular response mediated by GPCR results from the functional integration of an intricate network of intracellular signaling pathways. The intracellular signaling pathways activated by GPCR signaling include cAMP/PKA pathway, Ca2+/PKC pathway, Ca2+/NFAT pathway, PLC pathway, Protein tyrosine kinase pathway, PKC/MEK pathway, p43/p44MAP pathway, p38 MAP pathway, PI-3 Kinase pathway, NO-cGMP pathway, Rho pathway, NFkB pathway and Jak/Stat pathway. In this GEArray, we have included membrane receptors and transcriptional target genes as pathway representative markers. These genes were reported to response to GPCR signaling through the indicated pathway. Through pathway specific inhibitor studies, it is shown that multiple pathways can regulate the same target gene simultaneously or at different phases. Therefore, this GEArray not only provides you a tool to identify the activated pathways, but also allow you to generate a pathway activation profile at each time point of stimulation for your specific GPCR. The GPCR-specific pathway activation profile can then be used for screening of ligands, agonists and antagonists.
  Catalog number MM-025 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site