title: Oligo GEArray® Mouse Hematopoietic Stem Cells and Hematopoiesis Microarray
status: Public on Jul 23 2009
contact.city: Hackensack
contact.first: Michael
contact.last: Appel
contact.email: appel.m.j@gmail.com
contact.state: NJ
contact.address: 30 Prospect AVE-room 350
contact.department: Oncology Research
contact.country: USA
contact.institute: Hackensack University Medical Center
organism: Mus musculus
description: Hematopoietic stem cells (HSCs) are defined as self-renewing cells with the capacity to differentiate into any of more than eight distinct blood-cell lineages. Hematopoiesis is the development of blood-cell lineages from HSCs through progenitor stem cells. Progenitor stem cells are morphologically indistinguishable from HSCs even while committed to development into specific blood-cell lineages. These progenitor stem cells can be distinguished, however, by lineage-specific molecular markers. The development of HSCs from embryonic stem cells, ex-vivo expansion of HSCs, or hematopoiesis involves specific cytokines, transcription factors, and the Notch and Wnt signaling pathways. This array contains genes encoding lineage-specific markers as well as the cytokines, signaling molecules, and other regulators that are important in stem cell commitment and differentiation. Use this array to study differential expression of genes involved in stem cell development among your experimental samples.
manufacture_protocol: See manufacturer website
  http://www.sabiosciences.com/microarrays.php