title: SuperArray GEArray Q Series Human G Protein-Coupled Receptor Gene Array II
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The GEArray Q Series Human G Protein-Coupled Receptor Gene Array II contains 96 genes encoding G Protein-Coupled Receptors (GPCR) and some of their regulators. The GPCR family includes at least 450 members, many of which are pharmacologically important proteins. These receptors and the biological pathways they regulate are the targets of hundreds of pharmaceuticals including antihistamines, neuroleptics, antidepressants, and antihypertensives. The GPCR family members are cell-surface receptors containing seven membrane-spanning regions. They transduce extracellular signals from their ligands (such as hormones, neurotransmitters, chemokines, autocrine and paracrine factors) by activating heterotrimeric guanine nucleotide-binding proteins (G proteins), which route the signals through several distinct intracellular signaling pathways. These signaling pathways then activate a response specific to each GPCR involved in diverse biological processes such as specific immune responses, learning and memory, embryonic development, gonadal development, or organismal homeostasis. This GEArray contains more than 70 of the more popular GPCR genes and more than 20 genes representing regulators of GPCR activity. The array is specifically designed to measure all of their relative expression levels simultaneously.
  Catalog number HS-046 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site