title: SuperArray GEArray Q Series Human Signal Transduction in Cancer Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The GEArray Q Series Human Signal Transduction in Cancer Gene Array contains 96 genes that are indicators or markers for the activation of 15 different signal transduction pathways involved in oncogenesis. The following signaling pathways are all represented on this array: MAP kinase, WNT, Hedgehog, STAT, stress (DNA damage, p53, hypoxia, heat shock, and p38 / JNK), inflammation (Cox-2 and NFkB), survival (NFkB and PI3K / AKT), hormonal (estrogen and androgen), and anti-proliferation (TGFb). The characteristics of an individual tumor depend on its tissue of origin as well as genetic and environmental factors. A unique combination of pathways is thus activated or inactivated in each tumor leading to uncontrolled growth. The ability to profile multiple pathways at once allows for a rapid assessment of all of the possible routes to tumor formation. Therefore, this GEArray is not only an effective tool to determine the pathways associated with particular tumors or immortalized cells, but could also be a novel tool for cancer typing. Through a simple side-by-side hybridization using your experimental RNA samples, the arrays provided in this kit, and a SuperArray Probe Synthesis Kit (sold separately), you can simultaneously determine the expression profile of these 96 markers of signal transduction pathways involved in tumorigenesis.
  Catalog number HS-044 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site