title: SuperArray GEArray Q Series Mouse Asthma Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Mus musculus
description: The GEArray Q Series Mouse Asthma Gene Array contains 80 genes pertinent to understanding asthma as a disease. The list of genes (see below) includes those encoding cytokines and their receptors, chemokines and their receptors, Th2 cytokine signaling molecules, and IgE receptors. Asthma is complex syndrome with many clinical manifestations. An elevation in the level of circulating IgE molecules can be indicative of allergies and asthma because these antibodies usually recognize the offending allergens. The IgE receptors on mast cells bind the IgE-antigen complexes and stimulate the cells to secrete cytokines and histamine that mediate the abnormally robust immune response. A shift in the T-helper cell population toward type 2 also plays an essential role in the pathogenesis of both allergies and asthma. Changes in the microbial environment may also account for the increasing prevalence of these conditions and the increase in Th2 populations. This concept may provide a conceptual basis for the development of new therapeutic strategies. Therefore, the Th2-specifc cytokines and the signaling pathway that regulates their expression have also been included on the array. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these asthma-related genes in your model system or patient- or animal- derived lavages.
  Catalog number MM-033 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site