title: Nimblegen Homo sapiens 4 array Tiling Set
status: Public on Nov 02 2007
contact.city: King of Prussia
contact.first: Joel
contact.last: Greshock
contact.state: PA
contact.address: 2301 Renaissance Blvd.
contact.department: Translational Medicine, Oncology
contact.country: USA
contact.institute: GlaxoSmithKline
organism: Homo sapiens
description: Feature Size: 16μm x 16μm
  Array Dimensions: 17.4mm x 13mm
  Overall Slide Dimensions: 1" x 3" (25 x 75mm)
  Build: HG18, NCBI 36
manufacture_protocol: Oligonucleotide arrays were designed as described by Selzer et al. (2005).  As part of the probe design process, regions targeted for coverage were repeat-masked and covered by 50-75 mer oligos spaced at ~1.5 kb intervals.  Probes were generated from both strands, and replicated on the array 3 times. This platorm consists of 4 arrays that collectively tile the entire human genome, each of which is broadly organized by chromosome.  These were constructed by maskless array synthesis technology (NimbleGen Systems Inc.), containing 385,000 oligonucleotides per array.  Each was synthesized by photolithography.
  Selzer, R. R. et al. Analysis of chromosome breakpoints in neuroblastoma at sub-kilobase resolution using fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer 44, 305-19 (2005).