title: SuperArray GEArray Q Series Mouse Th1-Th2-Th3 Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Mus musculus
description: There are three different classes of CD4+ T lymphocytes, or helper T cells: Th1, Th2 and Th3. An imbalance in the relative abundance of Th1 versus Th2 cells has been associated with asthma, atopic diseases, and autoimmune diseases. All three sub-types of T-helper cells can be identified by the cytokines they express upon activation. These cytokines in turn mediate specific immune responses. For example, endotoxin, a bacterial compound, is a potent stimulator of Th1 cells. Therefore, Th1 cells secrete cytokines that predominantly activate intracellular defenses against bacteria. On the other hand, a number of intractable viruses and parasites, such as HIV, hepatitis B and C, and malaria induce cellular responses that favor the Th2 sub-type allowing virally infected cells to remain undetected by the immune system. Activated Th2 cells, also usually associated with atopic diseases, secrete cytokines that activate extracellular defense mechanisms. Th3 cells share certain characteristics common to both Th1 and Th2 cells; however, their apparently unique regulatory and functional roles have defined them as a novel sub-type. To help you determine the relative abundances of these subtypes in your cell culture population or clinical sample, the Th1-Th2-Th3 Gene Array includes the cytokine genes that are representative of Th1, Th2 and Th3 cells. The array also contains genes encoding transcriptional factors that regulate the expression of these cytokines as well as other markers of CD4+ T lymphocytes.
  Catalog number MM-021 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site