title: NimbleGen custom human 385K ChIP-chip array (DP_FAIRE_HG18)
status: Public on Jul 01 2011
contact.city: Hinxton
contact.first: Dirk
contact.middle: Stefan
contact.last: Paul
contact.email: dp5@sanger.ac.uk
contact.address: Wellcome Trust Genome Campus
contact.department: Human Genetics
contact.country: United Kingdom
contact.institute: Wellcome Trust Sanger Institute
organism: Homo sapiens
description: Annotation in this record is based on NCBI human build 36 (hg18)
  We profiled chromatin structure at 62 non-redundant genetic loci representing all known associations (as of November 2009, CEU population) with 11 cardiovascular traits: coronary artery disease (CAD), (early-onset) myocardial infarction (MI), mean platelet volume (MPV), platelet counts (PLT), platelet signaling (PLS), white blood cell counts (WBC), red blood cell counts (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), systolic blood pressure (SBP), diastolic blood pressure (DBP), hypertension (HYP). We considered only genetic loci that reached genome-wide significance with the threshold of P<5x10-8 in a genome-wide association (GWA) study conducted with individuals of European ancestry. In addition, we selected genetic loci based on biological evidence, where there was suggestive evidence of association. For each locus, we included the entire recombination interval of the index SNP. If a recombination interval exceeded 500 kb, we included the closest target gene ±10 kb. In order to assess patterns of cell type specificity, we included eight lineage-specific reference genes (±2 kb) for each of megakaryocytes, erythroblasts and monocytes on the array.
manufacture_protocol: see manufacturer's web site www.nimblegen.com