title: SuperArray GEArray Q Series Human Glucocorticoid Signaling Gene Array
status: Public on Apr 09 2004
contact.city: Frederick
contact.first: SuperArray
contact.last: Bioscience Corporation
contact.email: support@superarray.net
contact.state: MD
contact.address: Suite 101, 7320 Executive Way
contact.country: USA
contact.institute: Technical Support
contact.phone: 301-682-9200
organism: Homo sapiens
description: The GEArray Q Series Human Glucocorticoid Signaling I Gene Array is designed to the profile the expression of genes controlling apoptosis and inflammation through the glucocorticoid-signaling pathway. The genes on this array represent the GC receptors and their associated proteins, targets involved in inducing apoptosis, and targets involved in suppressing inflammation. Glucocorticoids (GCs) are vital steroid hormones present in every human organ. They control a variety of physiological functions including immune responses, metabolism, cell growth and proliferation, development and reproduction. As seen below, the pro-apoptotic and anti-inflammatory functions of GCs result from both the induction and repression of gene expression. The distinct anti-proliferative function of GCs has led to their wide use as effective drugs for immunosuppression, treatment of inflammatory and immune diseases, and induction of cytotoxicity. Their ability to induce apoptosis has been used effectively to treat hematological malignancies including leukemia, lymphoma and myeloma. Therefore, this array can help you systematically study GCs signaling, screen for biologicals to enhance or inhibit GC signaling, and further examine the role of GCs in apoptosis and inflammation.
  Catalog number HS-045 (Superarray, Frederick, MD)
  Platform_weblink: http://www.superarray.com/home.php
manufacture_protocol: see manufacturer's web site