The effect of mercuric chloride intoxication on urinary psi-glutamyl transpeptidase excretion in the sheep.
The activity of the enzyme psi-glutamyl transpeptidase (psi-GT) was measured in the urine of sheep. In clinically normal animals the mean value was 6-3+/-0-6 mU/ml. In sheep with  kidney damage induced by the administration of mercuric chloride there were marked increases in urinary concentrations of psi-GT, in some cases values in excess of 1000 mU/ml were recorded. This enzyme may be of value in the diagnosis of certain forms of renal disease.
D000818:Animals; D005260:Female; D008297:Male; D008630:Mercury Poisoning / Q000201:enzymology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000652:urine*
D005723:gamma-Glutamyltransferase