[The effect of psychotropic substances (aminazin, majeptil, trisedil) on protein synthesis in different regions of the rat brain].
Experiments were conducted on rats; a study was made of methionineS35 incorporation into the sum total proteins isolated from various portions of the brain after a single administration of chlorpromazine, majeptil and tricedil. A generalized depression of protein synthesis in all the structures, except the medulla oblongata, followed chlorpromazine administration in one and three hours. A stimulating effect is characteristic of majeptil in the majority of the brain portions. The action of tricedil was accompanied by reduction of methionine-S35 incorporation into the proteins of the majority of the brain structures and by an increase in its incorporation into the olfactory lobes. As supposed, changes in the protein synthesis in individual structures of the brain served as an important link in the action mechanism of psychotropic preparations on the organism.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001931:Brain Mapping; D002746:Chlorpromazine / Q000494:pharmacology*; D008297:Male; D008715:Methionine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D014272:Trifluperidol / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D010640:Phenothiazines; D008715:Methionine; D014272:Trifluperidol; D002746:Chlorpromazine
O vliianii psikhotropnykh sredstv (aminazin, mazheptil, trisedil) na sintez belka v raznykh otdelakh mozga krys