[Immunosuppressive properties of vinblastine and colchicine].
The action of vinblastine and colchicine on the populations of antibody-forming cells, their precursors and stem cells using a model of primary immune response and in the transplantation system was studied using techniques by Jerne and Nordin (1963), Kennedy et al. (1965), and Till and McCulloch (1961). It was discovered that vinblastine and colchicine, at single administration 48 hours after immunization, inhibited immune response completely. The administration of colchicine and vinblastine to a donor gave an exponential decrease of in foci-forming cell number in a recipient in the system of syngenic transfer. But at the same time, vinblastine at small doses stimulated population of antibody-forming and stem cells, whereas at large doses it was not effective. Colchicine, in contrast, strongly inhibited both antibody-forming and haemopoietic cells in the recipient.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007166:Immunosuppressive Agents; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D014181:Transplantation Immunology / Q000187:drug effects*; D014185:Transplantation, Isogeneic; D014747:Vinblastine / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D014747:Vinblastine; D003078:Colchicine
Izuchenie immunodepressivnykh svoĭstv vinblastina i kolkhitsina.