[Reaction kinetic studies on the formation of n-nitrosoephedrine in vitro and in vivo (author's transl)].
N-Nitrosoephedrine was synthesized at a high yield (greater than 90%). The influence of pH on the reaction process (ephedrine sulfate + nitrous acid in hydrochloric acid) was investigated and the pH-optimum determined. Furthermore the influence of coffee, ascorbic acid, citric acid, cyclamate/saccharin (10:1), smoke condensate of cigarettes, glucose and ethanol on the reaction process was also determined. The tests with animals (rats) showed that N-nitrosoephedrine could be detected in serum after the oral application of ephedrine sulfate and sodium nitrite.
D000818:Animals; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009603:Nitroso Compounds / Q000097:blood / Q000138:chemical synthesis*; D051381:Rats
D009603:Nitroso Compounds; D004809:Ephedrine
Reaktionskinetische Untersuchungen zur Entstehung von N-Nitrosoephedrin in vitro und in vivo.