Effect of ritodrine on uterine activity, heart rate, and blood pressure in the pregnant sheep: combined use of alpha or beta blockade.
Ritodrine hydrochloride was administered parenterally to pregnant ewes during spontaneous or oxytocin-induced uterine activity. The effects of ritodrine on the uterus and cardiovasculature were assessed both with and without simultaneous administration of either alpha or beta blockade. Ritodrine was found to be an effective inhibitor of both spontaneous and induced uterine activity. Ritodrine did cause maternal tachycardia but no significant hypotension. Alpha-adrenergic blockade did not influence the effects of ritodrine. Beta blockade with propranolol reversed the uterine and cardiovascular effects of ritodrine, whereas beta blockade with practolol reversed the cardiovascular effects without interfering with the inhibition of uterine activity produced by ritodrine.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007743:Labor, Obstetric; D010121:Oxytocin / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011247:Pregnancy / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D012312:Ritodrine / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep; D014590:Uterine Contraction / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D010643:Phenoxybenzamine; D010121:Oxytocin; D011433:Propranolol; D012312:Ritodrine; D011217:Practolol