Enhancement of sulphatide metabolism in the hypertrophied kidney of C3H/He mouse with reference to [Na+, K+]-dependent ATPase.
Sulphatide (cerebroside sulphate) metabolism of C3H/He mouse kidney was investigated in the course of compensatory renal hypertrophy in association with the change of [Na+,K+]-dependent ATPase, arylsulfatase A and beta-galactosidase activity. A remarkable increase in 35S incorporation into kidney sulphatide was observed 24 hours and especially 7 days after unilateral nephrectomy. In contrast, no significant alteration of 32P incorporation into major phospholipids such as phosphatidylcholine, phosphatidylethanolamine and sphingomyelin was demonstrated in the compensatory hypertrophied mouse kidney. [Na+, K+]-dependent ATPase increased to 126% of control in the remaining kidneys on 7 days after operation. Specific increase in 35S specific activity of kidney sulphatide suggests its possible link with the process of active ion transport through membrane-bound [Na+,K+]-dependent ATPase. Arylsulphatase A activity increased to 151% of control on  days, while little change was observed in beta-galactosidase activity. These results suggest a sole concern of a turnover of sulphate moiety of sulphatide molecule in the elevated metabolism.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D002553:Cerebroside-Sulfatase / Q000378:metabolism; D005696:Galactosidases / Q000378:metabolism; D006984:Hypertrophy; D007668:Kidney / Q000201:enzymology* / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D009392:Nephrectomy; D010743:Phospholipids / Q000096:biosynthesis; D013433:Sulfoglycosphingolipids / Q000378:metabolism*; D013997:Time Factors
D010743:Phospholipids; D013433:Sulfoglycosphingolipids; D002553:Cerebroside-Sulfatase; D005696:Galactosidases; D000251:Adenosine Triphosphatases