Ontogenetic development of NADH-dependent methemoglobin reductase in erythrocytes of man and rat.
Ontogenetic development of NADH-dependent methemoglobin reductase was followed in humans and rats. The human kinetic profile differs from that in the rat. The low level of methemoglobin reductase in human infants at birth and for the first months of life may provide a partial explanation of the particular susceptibility to methemoglobinemic agents of this age group.
D000328:Adult; D000375:Aging; D000818:Animals; D042966:Cytochrome-B(5) Reductase / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013045:Species Specificity
D009249:NADP; D009247:NADH, NADPH Oxidoreductases; D042966:Cytochrome-B(5) Reductase