Effects of adrenalectomy and glucocorticoid therapy on enzyme activities in mammary and adipose tissues from lactating rats.
Several mammary and adipose enzymes were measured in normal, adrenal-ectomized, adrenalectomized cortisol-treated, and intake-restricted lactating rats. Acetyl-CoA carboxylase, lipoprotein lipase, and triglyceride synthetase complex activities in mammary tissue were unchanged by intake restriction, decreased by adrenalectomy, and increased by glucocorticoid-replacement therapy. Malic dehydrogenase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and lipoprotein lipase activities in adipose were unchanged after adrenalectomy.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000273:Adipose Tissue / Q000201:enzymology*; D000315:Adrenalectomy; D000818:Animals; D003066:Coenzyme A Ligases / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007774:Lactation; D008071:Lipoprotein Lipase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000201:enzymology*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011247:Pregnancy; D012313:RNA / Q000378:metabolism; D051381:Rats
D012313:RNA; D004247:DNA; D008291:Malate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005992:Glycerol-3-Phosphate O-Acyltransferase; D008071:Lipoprotein Lipase; D010744:Phosphoric Monoester Hydrolases; D003066:Coenzyme A Ligases; D000103:Acetyl-CoA Carboxylase; D006854:Hydrocortisone