Identification of beta-adrenoceptors and histamine receptors in the cat nasal vasculature.
The responses of the nasal capacitance vessels of the cat were recorded following intra-arterial injections of beta-adrenoceptor agonists and histamine H1-and H2-receptor agonists. Isoprenaline evoked vasodilation and propranolol (beta-adrenoceptor antagonist) caused a parallel shift to the right of the isoprenaline log dose-response curve. Histamine, 2-(2-aminoethyl)pyridine (H1-agonist) and 4-methylhistamine (predominantly H2-agonist) all evoked vasodilation. Metiamide (H2-antagonist) produced a further small parallel shift to the right of the histamine log dose-response curve after the administration of mepyramine (H1-antagonist). It is concluded that the nasal capacitance vessels of the cat contain beta 2-adrenoceptors and H1-and H2-histamine receptors.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D002415:Cats; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D008785:Metiamide / Q000494:pharmacology; D009666:Nose / Q000098:blood supply*; D011433:Propranolol / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D011968:Receptors, Histamine / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D006633:Histamine Antagonists; D008761:Methylhistamines; D011725:Pyridines; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011968:Receptors, Histamine; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D008785:Metiamide; D006632:Histamine; D011433:Propranolol; D011738:Pyrilamine; D007545:Isoproterenol