[Induction of tyrosine aminotransferase (EC 2.5.1.5) by nicotinamide in rat liver (author's transl)].
In intact rats nicotinamide induces an increase of tyrosine aminotransferase depending on the dose of nicotinamide. In adrenalectomized rats an increase of tyrosine aminotransferase activity is only found up to a dose of 250 mg/kg nicotinamide. The combination of nicotinamide with L-methionine and/or cortisone acetate does not cause a significant increase of the enzyme activity, which, however, can be seen in the presence of L-tyrosine.
D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005508:Food Deprivation; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008715:Methionine / Q000494:pharmacology; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats; D014443:Tyrosine / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D009536:Niacinamide; D014443:Tyrosine; D008715:Methionine; D014444:Tyrosine Transaminase; D003348:Cortisone
Induktion der Tyrosin-Aminotransferase (EC 2.5.1.5) in der Rattenleber durch Nicotinsäureamid.