The effects of TAB and of adrenergic blocking drugs on the course of the experimental irradiation disease.
The experiment is aimed at establishing the consequences of the endotoxic stress (TAB) associated with alpha- or beta-adrenergic selective blocking drugs on the course of the acute irradiation disease in rats (700R, gamma rad Co60). TAB administered before or after irradiation, alone or associated with propranolol, increases the surviving rate at 30 and 60 days from exposure as compared to the controls (LD 95/30 days). Generally, dibenzyline has unfavourable effects on mortality and survival rate at the mentioned intervals. Based on the data obtained, an adrenergic component is analysed in achieving the survival increase by TAB and beta-adrenergic blocking substances; a hypothesis about the mechanisms involved is advanced.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats; D014436:Typhoid-Paratyphoid Vaccines / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D014436:Typhoid-Paratyphoid Vaccines; D010643:Phenoxybenzamine; D011433:Propranolol