Comparison of anileridine and pethidine in preventing pain responses during nitrous oxide-oxygen anaesthesia.
The analgesic potency of anileridine and pethidine was compared in 28 patients by measuring their effect on withdrawal movements caused by pinching of the skin or by surgery during N2O + O2 anaesthesia. It appeared that anileridine is 3.5 to 4 times as potent as pethidine on a weight basis. In equianalgesic doses the incidence of side effects was equal after both drugs.
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007540:Isonipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009609:Nitrous Oxide; D010146:Pain; D010313:Partial Pressure; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D000759:Adjuvants, Anesthesia; D007540:Isonipecotic Acids; D002245:Carbon Dioxide; D008614:Meperidine; D009609:Nitrous Oxide