[Effect of sodium dichloroacetate on hyperlactatemia and hyperpyruvicemia induced by phenformin in the dog].
In the normal anesthetized dog a continuous perfusion of sodium dichloroacetate (30 mg/kg.h) prevents the increase in blood lactates and pyruvates as well as the lowering of the arterial pH induced by the intraduodenal administration of phenformin (30 mg/kg). Furthermore a perfusion of sodium dichloroacetate (7.5 mg/kg.mn) during 20 minutes, three hours after the administration of phenformin, tends to improve the utilization of blood lactates and pyruvates.
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D010629:Phenformin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*
D000085:Acetates; D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D010629:Phenformin
Effet du dichloroacétate de sodium sur l'hyperlactatémie et l'hyperpyruvicémie provoquées par la phenformine chez le chien