Improvement of fertility and semen quality in men treated with a combination of anticongestive and antibiotic drugs.
The effects of a combined therapy of antibiotics and antiinflammatory drugs was evaluated in 344 men referred to our clinic for treatment of infertility. Physical signs of congestion, usually not severe, were detected in 244 men. The treatment caused significant improvement in semen quality, especially in sperm concentration, morphology and motility. Forty percent of the wives became pregnant. There was a striking relationship between increase in morphologically normal spermatozoa and incidence of pregnancy. It is speculated that the therapy had its major effect at the level of the epididymis and/or testis.
D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D012661:Semen / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013299:Streptodornase and Streptokinase / Q000494:pharmacology / Q000627:therapeutic use*; D013754:Tetracyclines / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D004917:Erythromycin; D002701:Chloramphenicol; D000667:Ampicillin; D013299:Streptodornase and Streptokinase; D010653:Phenylbutazone