Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease.
Eleven instances of a mixed acid-base disorder consisting of chronic respiratory acidosis and metabolic alkalosis were recognized in eight patients with chronic obstructive lung disease and carbon dioxide retention. Correction of the metabolic alkalosis led to substantial improvement in blood gas values and clinical symptoms. Patients with mixed chronic respiratory acidosis and metabolic alkalosis constitute a common subgroup of patients with chronic obstructive lung disease and carbon dioxide retention; these patients benefit from correction of the metabolic alkalosis.
D000086:Acetazolamide / Q000627:therapeutic use; D000142:Acidosis, Respiratory / Q000150:complications*; D000368:Aged; D000471:Alkalosis / Q000150:complications* / Q000188:drug therapy; D000643:Ammonium Chloride / Q000627:therapeutic use; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D002908:Chronic Disease; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008173:Lung Diseases, Obstructive / Q000150:complications*; D008875:Middle Aged
D001639:Bicarbonates; D000643:Ammonium Chloride; D000086:Acetazolamide