Mechanism of senescence of red blood cells.
An integral hypothesis is submitted on the interaction of endogenous and exogenous factors in the mechanism of senescence of erythrocytes and on their selective phagocytosis by autologous macrophages. A method that allows quantitative determination and preparative yield of senescent erythrocytes is proposed.
D000255:Adenosine Triphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002469:Cell Separation; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000378:metabolism; D006384:Hemagglutination; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010587:Phagocytosis; D012794:Sialic Acids / Q000378:metabolism
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D012794:Sialic Acids; D009243:NAD; D009249:NADP; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium