Oxidative reactions of hydroxylated chlorpromazine metabolites.
The oxidation pathways of two hydroxylated chlorpromazine metabolites were investigated using modern electrochemical techniques. Upon oxidation, the 7-hydroxy derivative of chlorpromazine rapidly reacts to form the 7,8-dihydroxy derivative and a substituted quinone. The oxidation potentials for both compounds were determined in the pH 3-8 range. The importance of these redox reactions and potentials to the pharmacology of the materials is discussed.
D002746:Chlorpromazine / Q000378:metabolism*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D006900:Hydroxylation; D010084:Oxidation-Reduction
D002746:Chlorpromazine