Enthalpies of hydrogen bonding in psychotropic drugs.
The enthalpy of hydrogen bonding of some antipsychotic, antidepressant, anticonvulsant, and antianxiety agents with phenol, as determined from IR and NMR spectroscopic measurements, was shown not to be responsible for differences in activity within the drug classes. These results support a theoretical prediction advanced for anticonvulsant activity.
D000928:Antidepressive Agents / Q000032:analysis; D014150:Antipsychotic Agents / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols; D011619:Psychotropic Drugs / Q000032:analysis; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D014149:Tranquilizing Agents / Q000032:analysis
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D010636:Phenols; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents