Effect of dihydroergotoxine on activities of beta-receptor stimulators.
The effect of dihydroergotoxine (DET), an alpha-receptor blocker, on the bronchodilating effect of various beta-receptor stimulators was examined using the isolated guinea-pig tracheal smooth muscle. Relaxation of isolated guinea-pig tracheal smooth muscle with isoproterenol hydrochloride, salbutamol hemisulfate and clorprenaline hydrochloride, was markedly increased by continous infusion of DET. This result may suggest that DET, an alpha-receptor blocker, can be used together with bronchodilators such as beta-receptor stimulator for the treatment of various chronic obstructive pulmonary diseases.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D014132:Trachea / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D004088:Dihydroergotoxine