Effect of adamantane derivatives on the activity of orthomyxovirus RNA-dependent RNA polymerase.
The effect of several adamantane derivatives on the activity of virion-associated RNA-dependent RNA polymerase of fowl plague virus (FPV) and influenza B virus was studied in vitro. Some of the derivatives inhibited the activity of the polymerase by 60 per cent. A correlation was established between the previously demonstrated capacity of these inhibitors to suppress orthomyxovirus reproduction in vivo and their ability to reduce the activity of virion-associated RNA-dependent RNA polymerase in vitro.
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D009980:Influenza A virus / Q000201:enzymology* / Q000254:growth & development; D009975:Orthomyxoviridae / Q000201:enzymology* / Q000254:growth & development; D012316:RNA Nucleotidyltransferases / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
D001952:Bridged-Ring Compounds; D012316:RNA Nucleotidyltransferases; D012324:RNA-Dependent RNA Polymerase; D000218:Adamantane