Actions of the muscle relaxant chandonium iodide on guinea-pig ileum and vas deferens preparations.
The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a-methyl-3beta-pyrrolidino-17a-aza-D-homo-5-androstene dimethiodide) have been investigated on guinea-pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0-1-10-0 mug ml(-1); 1-6 X 10(-7) M-1-6 X 10(-5) M) had weak muscarinic receptor blocking action (pA2 is 5-7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10-50 mug ml(-1); 1-6-8-1 X 10(-5) M) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 mug ml(-1) chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000736:Androstenes / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D000736:Androstenes; D009466:Neuromuscular Blocking Agents; D011759:Pyrrolidines; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; C006958:chandonium iodide; D006632:Histamine; D002217:Carbachol; D000109:Acetylcholine; D009638:Norepinephrine