Effect of PGE1 on lipogenesis in perfused rat liver.
In perfused livers of 24 hour-fasted rats, PGE1 (prostaglandin E1) infused continuously into the perfusate, was found to cause a 45% increase in the incorporation of 1-14C acetate into liver fatty acids. PGE1 was found to have no effect, however, on the activity of the key lipogenic enzymes.
D000085:Acetates / Q000378:metabolism; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D064429:Fatty Acid Synthases / Q000378:metabolism; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats
D000085:Acetates; D011458:Prostaglandins E; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase