The effect of beta adrenergic blockade on bronchial sensitivity to acetyl-beta-methacholine in normal and allergic rhinitis subjects.
The effect of propranolol inhalation on sensitivity to methacholine inhalation was studied in normal and allergic rhinitis subjects to determine whether beta adrenergic blockade alters sensitivity to mediators in nonasthmatic atopic individuals. A partial beta adrenergic blockade is suggested as being instrumental in asthma. Hay fever patients studied showed similar effects and also developed asthma for the first time.
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001980:Bronchi / Q000187:drug effects; D005541:Forced Expiratory Volume; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D012130:Respiratory Hypersensitivity; D006255:Rhinitis, Allergic, Seasonal
D000319:Adrenergic beta-Antagonists; D008688:Methacholine Compounds; D011433:Propranolol; D007545:Isoproterenol