Inhibition of thermogenic drinking by beta-adrenergic antagonists.
The thirst induced by transfer of rats from air at 5 degrees C to air at 25 degrees C (thermogenic drink) was inhibited by d,1-, but not d-propranolol (6 mg/kg body weight) administered 0.5 h prior to removal from cold. The thermogenic drink was not inhibited by a similar administration of the beta1-adrenergic antagonist, practolol (50 and 150 mg/kg body weight), but was inhibited by the beta2-adrenergic antagonist, butoxamine (35 mg/kg body weight). The results are consistent with the suggestion that beta2-adrenergic receptors play a role in mediation of the thermogenic drink in rats.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002078:Butoxamine / Q000494:pharmacology; D003080:Cold Temperature; D004326:Drinking / Q000187:drug effects*; D005260:Female; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013696:Temperature; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D002078:Butoxamine; D011433:Propranolol; D011217:Practolol