Negative anion gap in a young adult with multiple myeloma.
A young patient with multiple myeloma was found to have a negative anion gap, with marked asymptomatic hyponatremia. The cause for his negative anion gap is thought to be the myeloma protein, which acts as a cation at physiological pH. Such a hyponatremia responds to reduction in serum concentration of paraprotein and should not be treated by sodium replacement.
D000328:Adult; D000838:Anions; D001774:Blood Chemical Analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007958:Leukocyte Count; D008297:Male; D009101:Multiple Myeloma / Q000097:blood*; D012964:Sodium / Q000097:blood*
D000838:Anions; D012964:Sodium