Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa.
Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa. Two H2-receptor antagonists-metiamide and cimetidine-behaved like competitive antagonists to histamine on gastric acid secretion in vitro. The isolated guinea pig gastric mucosa seems to be a suitable in vitro model for analysing the action of compounds on receptors involved in acid secretion.
D000818:Animals; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008785:Metiamide / Q000494:pharmacology*; D008954:Models, Biological; D011955:Receptors, Drug / Q000187:drug effects; D013890:Thiourea / Q000031:analogs & derivatives*
D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D011955:Receptors, Drug; D008785:Metiamide; D006632:Histamine; D013890:Thiourea