[Effect of dimedrol, diazoline, diprazin and ethysine on formation of the primary immune response].
Tests were conducted on mice of the CBA line, immunized through a single intraperitoneal administration of 0.5 ml of a 5% sheep erythrocytes suspension. Antihistaminic agents were introduced by the intraperitoneal route in a dose of 5 mg/kg, first at one time and then repeatedly at various intervals with respect to the initial immunization benadryl and diazoline, when administered in a single dose to mice 24 hours after immunization activated the primary immune response to sheep erythrocytes, whereas phenergan and ethisine manifested merely a tendency toward activation of the immunogenesis. The drugs under study failed to have any significant effect on the titres of serumal hemolysines and hemaglutinines.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010640:Phenothiazines / Q000494:pharmacology; D011398:Promethazine / Q000494:pharmacology; D011817:Rabbits; D013154:Spleen / Q000276:immunology*
D002243:Carbolines; D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D004155:Diphenhydramine; D011398:Promethazine
Vliianie dimedrola, diazolina, diprazina i étizina na formirovanie pervichnogo immunnogo otveta