Sulphasalazine is a potent inhibitor of prostaglandin 15-hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis.
Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15-hydroxydehydrogenase in rabbit colon (ID50 = 50 micrometer) and in several other organs of different species, but does not inhibit prostaglandin delta-13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.
D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003106:Colon / Q000201:enzymology / Q000648:ultrastructure; D006911:Hydroxyprostaglandin Dehydrogenases / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D008861:Microsomes / Q000201:enzymology; D011817:Rabbits; D012460:Sulfasalazine / Q000494:pharmacology* / Q000627:therapeutic use
D012460:Sulfasalazine; D006911:Hydroxyprostaglandin Dehydrogenases