[The pH-changes of the spinal fluid following bupivacaine (author's transl)].
The ph-changes of cerebral spinal fluid were measured following subarachnoid injection of bupivacaine 0.5% with and without adrenaline (1:200,000) during the three hours after the start of anaesthesia. At the same time drug precipitation was not detected. The ph-changes however, were pronounced but not enough to cause disturbances of the homoeostatic milieu. Especially no significant differences related to adrenaline were be found. The authors recommend bupivacaine 0.5% with and without adrenaline for spinal anaesthesia.
D000368:Aged; D000775:Anesthesia, Spinal / Q000379:methods; D002045:Bupivacaine / Q000494:pharmacology*; D002555:Cerebrospinal Fluid / Q000187:drug effects*; D004837:Epinephrine; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged
D002045:Bupivacaine; D004837:Epinephrine
Die pH-Veränderungen des Liquor spinalis durch Bupivacain.