Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen.
The immune response to a thymus-dependent antigen was depressed in vivo and in vitro in spleen cells from mice injected with LPS i.p. a few days before challenge with the antigen. Spleen cells from LPS-injected mice could, however, respond with increase DNA synthesis after activation with polyclonal B and T cell activators in vitro. The LPS-activated spleen cells could actively suppress normal cells in their response to the antigen sheep red blood cells. The suppressor cells contained in the LPS-activated spleens were most likely B lymphocytes, and the possible mechanism for their inhibitory function is discussed.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D004261:DNA Replication; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes; D004926:Escherichia coli; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D051379:Mice; D011135:Polysaccharides, Bacterial; D013154:Spleen / Q000276:immunology; D013296:Streptococcus pneumoniae; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D011135:Polysaccharides, Bacterial