Possible ion-pair-mediated absorption of mixidine II: plasma levels and histology.
Plasma intact 14C-mixidine levels in rats increased when the drug was administered intraduodenally with 1:3 and 1:5 molar ratios of 2-naphthalenesulfonic acid. Upon histological examination of the duodenums, similar doses of mixidine combined with 2-naphthalenesulfonic acid produced no dose-related lesions. These and previous observations demonstrate that mixidine absorption may be enhanced by ion-pair formation.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009282:Naphthalenesulfonates / Q000494:pharmacology; D011759:Pyrrolidines / Q000378:metabolism* / Q000633:toxicity; D051381:Rats
D009282:Naphthalenesulfonates; D011759:Pyrrolidines; C017540:mixidine