[Action of 3-beta adrenolytics on plasma renin activity measured by radioimmunology in genetically hypertensive rats].
Spontaneously hypertensive rats (SHR) have basal levels of plasma renin activity (PRA) lower than the ones observed in normal Sprague Dawley rats. Three beta blocking agents are orally administered to unanesthetized spontaneously hypertensive and normotensive rats. Propranolol and S 464 reduce PRA in spontaneously hypertensive and normotensive control rats. Pindolol do not lower PRA in normotensive rats but increases levels of PRA in spontaneously hypertensive rats. These results are discussed.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D007545:Isoproterenol / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology* / Q000627:therapeutic use; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D011433:Propranolol; D010869:Pindolol; D012083:Renin; D007545:Isoproterenol
Action de trois adrénolytiques bêta sur l'activité rénine plasmatique mesurée par radio-immunologie chez le rat génétiquement hypertendu.