The relationship between chemical structure and basicity in some morpholine compounds.
The influence of various substituents upon the pKa values of a series of 2-phenylmorpholines is discussed. The results are interpreted in terms of the preferred conformations of the morpholine ring and the inductive effect of the various substituents. The lack of analgesic activity in these compounds could be attributed to their low pKa.
D000698:Analgesia; D000818:Animals; D005260:Female; D006863:Hydrogen-Ion Concentration; D051379:Mice; D009025:Morpholines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009025:Morpholines