[Electromyography and AH/8165 in man].
This article concerns the electromyographical study of a synthetic curare derived from Azobis Arylimidazo (1-2a) Pyridinium (AH/8165) with a simultaneous recording of the spontaneous diaphragmatic activity and "testing" of the neuro-muscular transmission at the level of a peripheral muscle. This study shows that AH/8165 is a powerful non-depolirizing curarimimetic drug that quickly induces a neuro-muscular block at the level of the diaphragm and the peripheric muscles that can be reversed by anticholinesterasic drugs. Its reaction time is short (about 1 mn). There are importante individual variations in the duration of the neuromuscular blockage. Towards the end of the experience, tetanizing stimulations reveal a muscular fatigability in all the cases. No ill side-effects could be observed upon the cardiovascular system or any side-effects ascribable to a histaminergic mechanism.
D003472:Curare; D003964:Diaphragm / Q000187:drug effects / Q000502:physiology; D004576:Electromyography; D006801:Humans; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology; D011726:Pyridinium Compounds / Q000494:pharmacology*; D009435:Synaptic Transmission
D011726:Pyridinium Compounds; D003472:Curare
Electromyographie et AH/8165 chez l'homme