Antibacterial effect, plasmid curing activity and chemical structure of some tricyclic compounds.
Diethazine, amitriptyline and imipramine showed bacteriostatic and bactericidal effect on different bacteria. Chlorpromazine sulphoxide and fluorescein were ineffective even at 1000 microgram/ml. The antibacterial compounds deleted at 40-70% frequency the F'lac plasmid of Escherichia coli K12 LE-140.
D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D007786:Lactose Factors / Q000187:drug effects*; D010640:Phenothiazines; D010957:Plasmids / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010640:Phenothiazines