Identification of the in vitro N-oxidized metabolites of (+)- and (-)-N-benzylamphetamine.
This study has identified (+)- and (-)-N-benzyl-N-hydroxyamphetamine as metabolites after incubation of both (+)- and (-)-N-benzylamphetamine with fortified rabbit liver homogenates. The isomeric hydroxylamine metabolites were identified using the techniques of g.l.c., t.l.c. and combined g.l.c.-mass spectrometry (ms) and by comparison with results from reference samples. An additional novel metabolic product was identified after incubation of N-benzylamphetamine which had properties consistent with that of N-benzyl-amphetamine nitrone.
D000662:Amphetamines / Q000138:chemical synthesis / Q000378:metabolism*; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D011817:Rabbits; D013237:Stereoisomerism
D000662:Amphetamines