Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Neurospora crassa nicotinamide adenine dinucleotide specific isocitrate dehydrogenase depending on whether Mg2+ or Mn2+ serves as divalent cation.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D004789:Enzyme Activation; D006863:Hydrogen-Ion Concentration; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology*; D008345:Manganese / Q000494:pharmacology*; D009243:NAD / Q000494:pharmacology; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology*; D011485:Protein Binding
D002951:Citrates; D009243:NAD; D000249:Adenosine Monophosphate; D008345:Manganese; D007521:Isocitrate Dehydrogenase; D008274:Magnesium