The APUD cell concept.
Embryonic neural crest cells have been traced to the primitive entoderm where they differentiate into a family of hormone-producing cells, APUD cells. The APUD cell concept explains many otherwise seemingly dissociated clinical circumstances involving endocrine glands and hormone production by tumors.
D000588:Amines / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003653:Decarboxylation; D004064:Digestive System / Q000473:pathology; D004702:Endocrine Glands / Q000196:embryology; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D008303:Malignant Carcinoid Syndrome / Q000473:pathology; D009377:Multiple Endocrine Neoplasia / Q000196:embryology* / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism
D000588:Amines; D000596:Amino Acids; D006729:Hormones, Ectopic; D011498:Protein Precursors