Interference stimulated by tick-borne encephalitis virus: influence of divalent cations.
The effects of divalent cations (barium, cobalt, calcium, copper, magnesium, zinc and iron) on the interference of tick-borne encephalitis (TE) virus with vaccinia virus in Detroit-6 cell cultures were investigated. An increase in interference was shown in the presence of cobalt, zinc, copper, and magnesium. Barium and iron displayed a marked inhibitory action. But an increase in interference was not parallel with an increased production of interferon.
D001464:Barium / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002413:Cations, Divalent; D002460:Cell Line; D003035:Cobalt / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D004669:Encephalitis Viruses, Tick-Borne / Q000254:growth & development*; D007372:Interferons / Q000096:biosynthesis; D007501:Iron / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D014616:Vaccinia virus / Q000254:growth & development; D014762:Viral Interference / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology
D002413:Cations, Divalent; D001464:Barium; D003035:Cobalt; D003300:Copper; D007372:Interferons; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium