[Metabolic effects of ethyl alcohol the ways to correct them].
Tests conducted on albino male-rats demonstrated that with its intragastric administration in a dose of 3 g/kg ethanol produces a hypoxy-like situation in the organism, i.e. the oxygen tension in the liver and skeletal muscles decreases and the redox potential is activation during the 1st hour with succinate-cytochrome-c-oxidase of the liver mitochondria with concomitantly activated oxidation of succinic acid. The activity of NAD-dependent dehydrogenases goes down and in the blood occur acidotic shifts in the acid-base equilibrium (ABE). Twenty four hours after a single administration of ethanol the activity of all the study liver enzymes declines with the acidotic ABE shifts remaining unchanged. The used mixture of glutamate and sodium succinate appreciably decreases the blood ethanol level, corrects metabolic effects of ethanol and increases the survival of rats receiving lethal doses of ethanol.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000332:Aerobiosis; D000435:Alcoholic Intoxication / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D004338:Drug Combinations; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005971:Glutamates / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D051381:Rats; D013386:Succinates / Q000627:therapeutic use; D013997:Time Factors
D004338:Drug Combinations; D005971:Glutamates; D013386:Succinates; D000431:Ethanol
Nekotorye metabolicheskie éffekty étilovogo alkogolia i puti ikh korrektsii.