Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats.
Animals received either haloperidol (2 mg/kg) or probenecid (200 mg/kg) in conjunction with tyrosine (100 mg/kg) or its diluent. Striatal homovanillic acid levels increased in probenecid-treated animals to the same range whether they were given tyrosine or not. In haloperidol-treated animals the levels of homovanillic acid were significantly elevated in animals receiving tyrosine. Tyrosine and homovanillic acid levels were highly correlated as determined by linear regression analysis.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003342:Corpus Striatum / Q000201:enzymology / Q000378:metabolism*; D004298:Dopamine / Q000096:biosynthesis*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000096:biosynthesis; D008297:Male; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D014443:Tyrosine / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014443:Tyrosine; D014446:Tyrosine 3-Monooxygenase; D006220:Haloperidol; D011339:Probenecid; D004298:Dopamine; D006719:Homovanillic Acid