Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2.
An electrophoretic polymorphism of the peroxisomal enzyme D-amino acid oxidase was observed in NZC strain Mus musculus. F1 (NZC X BALB/c) mice showed a codominant allcle two-banded phenotype which is inconsistent with the dimeric subunit structure reported for this enzyme in other species. The enzyme locus (Dao) was shown to segregate independently of Hao-1, encoding the peroxisomal enzyme hydroxyacid oxidase (liver on A4 isozyme). Thus Dao is not linked to previously mapped peroxisomal enzyme loci, Hao-1 and Cs, closely localized on chromosome 2.
D000818:Animals; D002374:Catalase / Q000378:metabolism; D003605:D-Amino-Acid Oxidase / Q000378:metabolism; D005796:Genes; D008040:Genetic Linkage; D008099:Liver / Q000201:enzymology; D051379:Mice; D008830:Microbodies / Q000201:enzymology*; D009940:Organoids / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism; D011110:Polymorphism, Genetic
D010088:Oxidoreductases; D002374:Catalase; D003605:D-Amino-Acid Oxidase