Identification of 3-O-methyl-alpha-methyldopamine as a urinary metabolite of 3,4-methylenedioxyamphetamine in dog and monkey.
3-O-Methyl-alpha-methyldopamine has been separated by gas-liquid chromatography (GC) as a metabolite of MDA in the urine of dog and monkey. The metabolite was identified as its mono- and di-trifluoroacetyl derivatives by comparison of their GC and GC-mass spectral properties with those of synthetic compounds. The amount of metabolite increased on hydrolyzing the urine from dosed dogs and monkeys with a preparation containing beta-glucuronidase and sulfatase.
D015104:3,4-Methylenedioxyamphetamine / Q000378:metabolism*; D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D002849:Chromatography, Gas; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000652:urine; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives*; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D013058:Mass Spectrometry; D008722:Methods
D000662:Amphetamines; D015104:3,4-Methylenedioxyamphetamine; D003846:Deoxyepinephrine; D004298:Dopamine