Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics.
The present findings of increased microvascular protein passage are compatible with the hypothesis that the organic, histologically demonstrated diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i.e., the concept of plasmatic vasculosis. Arterial hypertension, frequently present in diabetes, enhances the development of arteriolar hyalinosis. Effective treatment of diabetes and hypertension arrests development of the microvascular lesions.
D000293:Adolescent; D000328:Adult; D001769:Blood; D001794:Blood Pressure; D001798:Blood Proteins / Q000378:metabolism*; D001810:Blood Volume; D002196:Capillaries / Q000503:physiopathology*; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000150:complications; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D010539:Permeability; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000378:metabolism
D001798:Blood Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin; D001613:beta 2-Microglobulin; D005947:Glucose