The reaction between thiols and 8-azidoadenosine derivatives.
Thiols react at room temperature in dilute solution with 8-azidoadenosine and its nucleotides to give the corresponding 8-aminoadenosine derivatives. The reaction which takes place in the dark is base-catalysed and is particularly rapid when dithiols, e.g. dithiothreitol are used.
D000227:Adenine Nucleotides; D000241:Adenosine / Q000031:analogs & derivatives* / Q000528:radiation effects; D001386:Azides; D004229:Dithiothreitol; D006863:Hydrogen-Ion Concentration; D008027:Light; D008623:Mercaptoethanol
D000227:Adenine Nucleotides; D001386:Azides; D008623:Mercaptoethanol; D000241:Adenosine; D004229:Dithiothreitol