[The preprogramming of behavior patterns by changing the neurotransmitter metabolism in the early postnatal ontogenesis of albino rats].
Changes in neurotransmitter concentrations, which are brought about by the administration of neurotropic pharmaceuticals to albino rats at the time of differentiation of the brain, may have a lasting effect upon the reactivity and adaptability of adult animals to environmental factors and give rise to specific patterns of behavior. 1. Pargyline, when administered neonatally, resulted in a reduction of learning power, decrease in the power of retention, as well as reduction of the decision-making ability. 2. Reserpine gave an improvement of learning power, but simultaneously decreased both the power of retaining what had been learnt and the decision-making ability. 3. Pyridostigmine gave a marked improvement of adaptability which was evidenced in higher learning power, greater retentiveness, and better decision-making ability.
D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D003657:Decision Making / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology*; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D012110:Reserpine; D010293:Pargyline; D011729:Pyridostigmine Bromide
Zur Möglichkeit einer Vorprogrammierung von Verhaltensweisen durch Veränderung des Neurotransmitter-Stoffwechsels in der frühpostnatalen Ontogenese von Albinoratten.