The regulation of physiological changes during mammalian aging.
Much evidence suggests that intrinsic molecular or cellular aging mechanisms need not be invoked to explain most age-related cellular changes and pathologcical conditions. Analysis of a widely scattered literature indicates that hormones and neural factors regulate a great number of cellular aging phenomena of mammals. It is proposed that age-related changes after maturation result from an extension of the neural and endocrine mechanisms that control earlier development and that produce a regulatory cascade of changing neural, endocrine, and target-tissue interactions.
D000375:Aging; D000818:Animals; D001921:Brain / Q000502:physiology; D004194:Disease; D004702:Endocrine Glands / Q000502:physiology; D005260:Female; D005838:Genotype; D006801:Humans; D008136:Longevity; D008297:Male; D009069:Movement Disorders / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology; D010053:Ovary / Q000502:physiology; D010860:Pigments, Biological / Q000378:metabolism; D010902:Pituitary Gland / Q000502:physiology; D012098:Reproduction
D018377:Neurotransmitter Agents; D010860:Pigments, Biological