Effects of parenteral secretin--cholecystokinin and of duodenal acid perfusion on gastric secretion in duodenal ulcer patients.
The effect of parenteral secretin-cholecystokinin and duodenal acid perfusion on broth-stimulated gastric acid secretion was studied in 11 duodenal ulcer patients. Statistically significant inhibition occurred in both experimental conditions. The effect of secretin-cholecystokinin was more marked than the effect of duodenal acid perfusion. A poorly responsive subgroup of patients appeared to be responsible for the diminished inhibitory effect of duodenal acid perfusion. In this poorly responsive group there was a diminished duodenal volume response as well as diminished duodenal acid clearing. We conclude that there may exist a diminished release of gastrointestinal hormones such as secretin and cholecystokinin in certain duodenal ulcer patients.
D000328:Adult; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000209:etiology / Q000503:physiopathology*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010477:Perfusion; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D012633:Secretin; D002766:Cholecystokinin