Search for herpetic antibodies in the cerebrospinal fluid in senile dementia and mental retardation.
Complement-requiring neutralizing antibodies to herpes simplex type 1 virus (HSV 1) in titres from 2 to greater than 16 were detected in the cerebrospinal fluid (CSF) of 47% senile patients with various forms of dementia, but in none of mentally retarded adolescents and adults suffering from various neurologidal diseases. Also the incidence of HSV 1 serum antibodies in elevated titres (larger than or equal to 512) was increased in senile demented patients (61%) as compared with persons in normal senium (31%), normal adults (15%), mentally retarded adolescents (17%) and prisoned felons with low IQ (45-47%).
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D002555:Cerebrospinal Fluid / Q000276:immunology*; D003704:Dementia / Q000134:cerebrospinal fluid*; D006801:Humans; D008607:Intellectual Disability / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009500:Neutralization Tests; D018139:Simplexvirus / Q000276:immunology*
D000914:Antibodies, Viral