Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs.
Presented in this paper are the effects of chlorpromazine, clozapine, d-amphetamine and diazepam on DRL behavior in rats. D-Amphetamine and diazepam, which showed similar effects on response errors, could be identified on the basis of burst responding and drug interaction. Clozapine, a new antipsychotic agent which does not cause extrapyramidal side effect in man affected DRL behavior in the same way as did chlorpromazine. Thus, DRL schedules are probably not useful in differentiating various neuroleptic agents.
D000818:Animals; D014151:Anti-Anxiety Agents; D001522:Behavior, Animal / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012055:Reinforcement Schedule; D014149:Tranquilizing Agents
D014151:Anti-Anxiety Agents; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents; D003024:Clozapine; D003975:Diazepam; D003913:Dextroamphetamine; D002746:Chlorpromazine