[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
A study was made of the interrelationship between the minimal effective doses of pseudoclonic and clonico-tonic convulsions, and also tonic extension caused by the intravenous injection of corazol to mice and the effect of anticonvulsive action of sulazepam and its metabolites (diazepam, desmethyldiazepam and oxadiazepam) on this process. It was shown that all the compounds under study increased the values of the minimal effective doses by the recorded indices of the convulsive seizure, whereas the maximum of the anticonvulsive activity was reached 15 minutes after the sulazepam and oxazepam, and 5 to 30 min after diazepam administration. There proved to be a distinct correlation between the minimal effective doses values of the recorded indices of the confulsive seizure in the control animals which also persisted after the administration of the agents under study. It is supposed that sulazepam and its metabolites increased the minimal effective doses of corazol for the recorded effects, but failed to alter the general picture of the convulsive attack and did not influence the dispersion corazol dose-effect dependence.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D003708:Nordazepam / Q000627:therapeutic use; D010076:Oxazepam / Q000627:therapeutic use; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013997:Time Factors
D014151:Anti-Anxiety Agents; D003708:Nordazepam; D010076:Oxazepam; D003975:Diazepam; D010433:Pentylenetetrazole
Analiz struktury komponentov sudorozhnogo deĭstviia korazola v usloviiakh vvedeniia mysham sulazepama i ego metabolitov