Effects of cimetidine and atropine sulfate on gastric secretion and healing of gastric and duodenal ulcers in rats.
Cimetidine, a new histamine H2-receptor antagonist (50 or 100 mg/kg) and atropine sulfate (15 mg/kg) given intraduodenally, markedly inhibited gastric secretion in pylorus-ligated rats. Cimetidine (100 or 200 mg/kg/day) given for 10 or 12 consecutive days orally in two divided doses, significantly promoted the healing rate of both gastric and duodenal ulcers induced in rats. Atropine (30 mg/kg/day) also significantly accelerated the healing of duodenal ulcers but failed to affect gastric ulcers.
D000818:Animals; D001285:Atropine / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy*
D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D001285:Atropine