Influence of adrenaline, dibenamine and dopamine on acidosis, hemoconcentration and lethality in protracted anaphylactic shock of guinea-pigs.
Protracted anaphylactic shock of guinea-pigs was accompanied by a marked decrease in blood pH, and an increase in hematocrit. Death ensued in 58.3% of the animals within 3 hr of observation. Infusion of adrenaline (20 mug/kg/min), after eliciting anaphylaxis, intensified the acidosis, and increased the lethality to 100%. Pretreatment with dibenamine (5 mg/kg) reversed the effect of adrenaline. Dopamine, infused in amounts of 200 mug/kg/min, acted similarly to the combination dibenamine/adrenaline. Hemoconcentration was neither prevented nor intensified by adrenaline. Dopamine, however, reduced significantly the anaphylactic increase in hematocrit.
D000138:Acidosis / Q000503:physiopathology*; D000707:Anaphylaxis / Q000401:mortality / Q000503:physiopathology*; D000818:Animals; D003983:Dibenzylchlorethamine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D008297:Male; D011738:Pyrilamine / Q000494:pharmacology
D003983:Dibenzylchlorethamine; D011738:Pyrilamine; D004298:Dopamine; D004837:Epinephrine