Reversibility of the blood-brain barrier dysfunction induced by acute hypertension.
An acute hypertensive episode of short duration (less than 3 min) induced by i.v. injection of angiotensin in rats resulted in a blood-brain barrier dysfunction that was rapidly reversible. Thus, no macroscopic extravasation was seen when Evans blue was given 10 or 20 min after angiotensin. A faint fluorescence (Evans blue-albumin) was seen in the walls of some intracerebral arterioles in a few rats given the tracer 10 min after angiotensin.
D000208:Acute Disease; D000804:Angiotensin II; D000818:Animals; D001812:Blood-Brain Barrier; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010313:Partial Pressure; D051381:Rats
D000804:Angiotensin II