Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury.
The effect of soft-tissue trauma was studied in dogs. Following injuries to the hind leg an aggregation of thrombocytes in blood and trapping in the lung was noted. Injury was initially followed by leukopenia and later by leukocytosis. Early hemolysis of red cells was observed. The injury was accompanied by complement activation. Its possible relation to hemolysis, leukopenia, thrombocytopenia, and increased insufflation pressure is discussed.
D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D003165:Complement System Proteins / Q000032:analysis; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006439:Hemodynamics; D006461:Hemolysis; D006614:Hindlimb / Q000293:injuries; D006863:Hydrogen-Ion Concentration; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology*; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D010100:Oxygen / Q000097:blood; D012119:Respiration; D013921:Thrombocytopenia / Q000209:etiology*; D014947:Wounds and Injuries / Q000097:blood* / Q000276:immunology / Q000503:physiopathology
D001798:Blood Proteins; D002245:Carbon Dioxide; D005340:Fibrinogen; D003165:Complement System Proteins; D010100:Oxygen