Cimetidine and the gastric mucosal barrier.
The histamine H2-receptor antagonist, cimetidine, when given topically or parenterally, did not affect net luminal Na+ gain or net luminal H+ loss in vagally-denervated pouches of antrectomised dogs. Cimetidine did not affect disruption of the mucosal barrier by 5 mmol/l or 20 mmol/l sodium taurocholate.
D000818:Animals; D001692:Biological Transport; D002463:Cell Membrane Permeability / Q000187:drug effects; D004285:Dogs; D005750:Gastric Juice; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013656:Taurocholic Acid / Q000494:pharmacology
D006146:Guanidines; D007093:Imidazoles; D013656:Taurocholic Acid; D012964:Sodium