The inhibition by ADP of NADPH-supported adrenal steroid 11beta-hydroxylation.
The 11beta-hydroxylation of deoxycorticosterone to form corticosterone in adrenal mitochondria has been found to be inhibited by ADP and ATP, with ADP being the more inhibitory of the two. The evidence suggests that the ADP directly affects the enzyme system.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000311:Adrenal Glands / Q000648:ultrastructure; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis; D003902:Detergents / Q000494:pharmacology; D008928:Mitochondria / Q000201:enzymology; D009249:NADP / Q000378:metabolism; D051381:Rats; D013250:Steroid Hydroxylases / Q000037:antagonists & inhibitors*
D003902:Detergents; D009249:NADP; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D013250:Steroid Hydroxylases; D003345:Corticosterone