[Effect of psychotropic and anticonvulsive preparations on transport ATPase in the renal tubules of the guinea pig].
The effect of 4 groups of medicamentous agents, viz. neoruleptics, tricyclic antidepressants, somnifacients and antiepileptics - on the activity of the transport ATPase and p-nitrophenylphosphatase from the renal tubules of the guinea pig was studied. Used in high concentrations neuroleptics suppress almost completely the activity of the enzyme, but in small doses influence but little that of the p-nitrophenylphosphatase. The butyrophenone derivatives have a mild effect upon the activity of the p-nitrophenylphosphatase and in low concentrations they stimulate it. The effect of tricyclic antidepressants closely approaches the one produced by neuroleptics-phenothiazines. Lithium carbonate leaves the enzyme intact. Barbiturates and antiepileptic agents inhibit but feebly these enzymes.
D009597:4-Nitrophenylphosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004794:Enzyme Repression / Q000187:drug effects; D006168:Guinea Pigs; D007684:Kidney Tubules / Q000187:drug effects* / Q000201:enzymology; D008094:Lithium / Q000494:pharmacology; D010640:Phenothiazines; D011188:Potassium / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010640:Phenothiazines; D011619:Psychotropic Drugs; D008094:Lithium; D012964:Sodium; D009597:4-Nitrophenylphosphatase; D000251:Adenosine Triphosphatases; D011188:Potassium
Vliianie psikhotrophykh i protivosudorozhnykh preparatov na transportnuiu ATF-azu pochechnykh kanal'tsev morskoĭ svinki