Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency.
Seven urinary metabolites of tryptophan-kynurenine pathway were measured in riboflavin-deficient, pyridoxine-deficient, pair-fed and natural diet baboons. The most significant changes in the pyridoxine-deficient baboons was a mean sevenfold increase in the excretion of xanthurenic acid and a threefold decrease in 3-hydroxy anthranilic acid. The riboflavin-deficient baboons showed a twelvefold increase in the excretion of anthranilic acid, and a tenfold decrease in 3-hydroxy kynurenine. Red blood-cell pyridine nucleotides decreased only in the pyridoxine-deficient baboons, while plasma 11-hydroxy corticosteroids increased only in the riboflavin-deficient baboons. These results are discussed in relation to enzymatic changes that may be expected during these deficiencies.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D000882:Haplorhini; D007737:Kynurenine / Q000378:metabolism; D008297:Male; D009243:NAD / Q000097:blood; D009249:NADP / Q000097:blood; D010215:Papio; D012257:Riboflavin Deficiency / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D009243:NAD; D007737:Kynurenine; D009249:NADP; D014364:Tryptophan