Studies on the polymorphism of carbromal.
Specimens of carbromal obtained by crystallization from various solvents were analyzed. After a 9-month storage period, the occurrence of three polymorphic forms (I, II and III) was ascertained. The metastable form III obtained by crystallization from dimethylformamide showed a reasonably high stability. Preliminary pharmacological tests revealed clear-cut differences in the therapeutic effect between a commercial specimen and the polymorphic modification III. The results presented here indicate the importance of polymorphism of carbromal for medicinal use.
D000818:Animals; D002697:Chloral Hydrate / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003460:Crystallization; D004357:Drug Synergism; D005019:Ethyl Ethers / Q000494:pharmacology; D006358:Hot Temperature; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D014508:Urea / Q000494:pharmacology*
D005019:Ethyl Ethers; D002697:Chloral Hydrate; D014508:Urea; D002746:Chlorpromazine; D010634:Phenobarbital