[Dynamic study of blood cholinesterase activity of paranoid schizophrenic patients].
A comparison of the cholinesterase blood activity with the clinical traits of the disease in 64 patients with paranoid schizophrenia treated by majeptile and haloperidol detected 2 variants in the reactivity of the enzyme link of the cholinergic system. A fluctuation of the cholinesterase activity of the sinusoid type (Ist variant) seen in patients with paranoial and hallucinatory-paranoid syndromes with a remission up to a year and more, speaks in favour of a relatively preserved compensatory-adaptive mechanisms in the neurohumoral regulation. The absence of fluctuation in the cholinesterase activity during the whole period of treatment (2nd variant) was characteristic of patients with negative results of treatment.
D000328:Adult; D002091:Butyrylcholinesterase / Q000097:blood; D002802:Cholinesterases / Q000097:blood*; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D010640:Phenothiazines / Q000008:administration & dosage* / Q000627:therapeutic use; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D012565:Schizophrenic Psychology
D010640:Phenothiazines; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D006220:Haloperidol
Dinamicheskoe izuchenie aktivnosti kholinésterazy krovi u bol'nykh paranoidnoĭ shizofrenieĭ.