A new putative neuroregulator of the extrapyramidal system.
A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after catecholamine depletion by pretreatment with a-methyl-para-tyrosine, and fully blocked by pretreatment with haloperidol, a dopamine receptor blocker. Therefore, via direct and/or indirect actions, 2-phenylethylamine may serve a neuroregulatory role in the extrapyramidal system.
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D005116:Extrapyramidal Tracts / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D018377:Neurotransmitter Agents; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D010627:Phenethylamines / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D051381:Rats; D012110:Reserpine; D013239:Stereotyped Behavior / Q000187:drug effects
D008781:Methyltyrosines; D018377:Neurotransmitter Agents; D010627:Phenethylamines; D012110:Reserpine; D006220:Haloperidol; D003913:Dextroamphetamine