The effects of purified cathepsin D infusions in intact animals.
Cathepsin D, a potent acid proteinase, has been implicated in the pathogenesis of circulatory shock. The infusion of purified preparations of cathepsin D into intact animals resulted in significant depressions in core body temperature but failed to reproduce the cardiovascular disturbances seen in shock states.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002403:Cathepsins / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D012769:Shock / Q000139:chemically induced*
D002403:Cathepsins