Effect of interferon and poly I:C on replication of influenza virus in organ cultures of human origin.
Interferon and poly I : C inhibited the growth of influenza virus in organ cultures of foetal nasal mucosa, trachea, oesophagus and adult nasal mucosa. No antiviral effect was observed in decidua organ cultures. The combined use of interferon and poly I : C resulted in the enhancement of the antiviral effect.
D004947:Esophagus / Q000196:embryology; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000254:growth & development; D007372:Interferons / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000196:embryology; D009924:Organ Culture Techniques; D011070:Poly I-C / Q000494:pharmacology*; D014132:Trachea / Q000196:embryology; D014779:Virus Replication / Q000187:drug effects*
D007372:Interferons; D011070:Poly I-C