Autoxidation of N-hydroxyphenylalkylamines: the inhibitory effect of some anions on copper catalysed  autoxidation of N-hydroxyphentermine.
The inhibitory effect of certain electrolytes and buffers on the copper catalysed autoxidation of N-hydroxyphentermine (2-hydroxylamino-2-methyl-1-phenylpropane) has been investigated. The presence of ions such as SO4(2-), Cl- or Br- markedly reduced the rate of oxidation. Phosphate and carbonate buffers had a similar effect with halides and phosphate buffers being the most inhibitory. The occurence of 2-methyl-2-nitro-1-phenylpropane and 2-methyl-1-phenylpropene-(1) as secondary oxidation products was also established.
D002021:Buffers; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper; D004573:Electrolytes; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D010645:Phentermine / Q000031:analogs & derivatives*
D002021:Buffers; D004573:Electrolytes; D003300:Copper; D010645:Phentermine