Crystalluria in normal subjects and in stone formers with and without thiazide and cellulose phosphate treatment.
Quantitative and qualitative studies have been made of the urinary crystals from a series of normal subjects and from stone formers with idiopathic hypercalciuria with and without treatment with thiazide diuretics and/or cellulose phosphate. The results obtained from mid-morning unprepared subjects seemed more helpful than those obtained following overnight collections or after a dry breakfast. Crystalluria was more common in stone formers than in normal subjects, but was seen in both groups. The most striking difference between these 2 groups was the almost complete absence of aggregation of oxalate crystals in the normal subjects. Cellulose phosphate greatly reduced phosphate crystals but resulted in a large increase in small oxalate crystals but without change in the incidence of aggregation of oxalate crystals. Thiazides also reduced occurrence of phosphate crystals but only gave a very small increase in oxalate crystals and also without change in aggregation of oxalate crystals.
D000328:Adult; D001581:Benzothiadiazines; D002118:Calcium / Q000652:urine*; D002130:Calcium Phosphates / Q000652:urine; D002482:Cellulose / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003460:Crystallization; D004232:Diuretics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000652:urine*; D010070:Oxalates / Q000652:urine; D010710:Phosphates / Q000627:therapeutic use*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*
D001581:Benzothiadiazines; D002130:Calcium Phosphates; D004232:Diuretics; D010070:Oxalates; D010710:Phosphates; D049993:Sodium Chloride Symporter Inhibitors; D002482:Cellulose; D002118:Calcium