Disturbances of extracellular pK, pNa and pH during no-flow anoxia.
The initial period of no-flow anoxia can be divided in at least two parts. During the first period lasting approximately 1 min., the O2 available in tissue gives rise to CO2 which increases hydrogen ion activity and may lead to Na+ influx2 (presumably due to increased  membrane permeability to Na+). In the second period, starting after the first minute, the increase in lactate content leads to further decrease in pH and is accompanied by extensive sodium influx and a distinct potassium efflux. However, it is striking that the isolated perfused rat liver is able to tolerate 1 hour of norm-flow anoxia without severe cellular damage, whereas two minutes of no-flow anoxia lead to a decrease in cellular ATP content by 28%.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007511:Ischemia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000098:blood supply*; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption; D010477:Perfusion; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism
D007773:Lactates; D002245:Carbon Dioxide; D009249:NADP; D000255:Adenosine Triphosphate; D012964:Sodium; D011188:Potassium