Action of glucagon and aspirin on ionic flux, mucosal blood flow and bleeding in the fundic pouch of dogs.
Into vagally denervated (Heidenhain) pouches of 4 dogs 25 ml of 0.1 M HCl was instilled and removed at 30 min intervals for 6 hours. During the 4th, 5th, and 6th 30 min periods the acid instillate contained 5 mg/ml of aspirin. Aspirin significantly increased gastric-mucosal clearance of aminopyrine (mucosal blood flow), outputs of Na+, Ca++, Mg++, hemoglobin, and plasma transferrin-Cr51 into the pouch contents, and disappearance of H+ from lumen to mucosa. Glucagon, 50 mug/kg subcutaneously was given during irrigation with aspirin and again 1 hour later. Glucagon did not significantly affect loss of acid from lumen to mucosa or the increase in Na+, K+, Ca++, and Mg++ effluxes caused by aspirin. Glucagon significantly decreased mucosal blood flow and the hemorrhage and loss of plasma protein into the instillate induced by aspirin.
D000632:Aminopyrine; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D003714:Denervation; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000503:physiopathology; D005934:Glucagon / Q000494:pharmacology*; D006851:Hydrochloric Acid / Q000378:metabolism / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism
D014168:Transferrin; D000632:Aminopyrine; D005934:Glucagon; D012964:Sodium; D008274:Magnesium; D006851:Hydrochloric Acid; D001241:Aspirin; D011188:Potassium; D002118:Calcium