[The importance of changes in whole-body balance of sodium and noradrenaline in essential hypertension (author's transl)].
In 22 patients with essential hypertension plasma levels and urine excretions of sodium and noradrenaline were studied before, during and after long-term beta-blockade with pindolol. The relation between mean blood pressure and the quotient of sodium-/noradrenaline-excretion changed during treatment (placebo r=-0.34; pindolol r=+0.31). During placebo there existed a significant (p is less than 0.03) correlation between blood pressure and sodium-excretion which disappeared during beta-blockade. No correlation between blood pressure and noradrenaline was seen during placebo, whereas during beta-blockade a significant (p is less than 0.003) correlation was observed. In contrast to the placebo period there was a significant positive correlation between sodium- and noradrenaline-excretion during long-term treatment with pindolol. It is concluded that whole-body balance of sodium and noradrenaline is an important factor in essential hypertension.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010869:Pindolol / Q000008:administration & dosage; D010919:Placebos; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood / Q000378:metabolism* / Q000652:urine
D000319:Adrenergic beta-Antagonists; D010919:Placebos; D012964:Sodium; D010869:Pindolol; D011188:Potassium; D009638:Norepinephrine
Zur Bedeutung einer Anderung der Gesamt-Bilanz von Natrium und Noradrenalin bei essentieller Hypertonie.