[The problems of adverse effects to the liver of alpha-methyldopa].
In 20 patients who were treated with alpha-methyldopa since at least one year the bilirubin content, the activities of aspartate and alanine-aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase as well as the retention of bromsulphalein were determined. In altogether 10 patients pathological findings of laboratory examinations were the result. The gamma-glutamyl transpeptidase activity proved to be particularly sensitive. By means of biopsy in 3 of these patients a fatty degeneration of the liver in stage I and in 4 of them a fatty degeneration of the parenchyma cell of minor degree were proved. A connection between duration and dosage of the treatment with alpha-methyldopa and these hepatological findings could not be ascertained statistically.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008099:Liver / Q000187:drug effects*; D008297:Male; D008750:Methyldopa / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D008750:Methyldopa; D005723:gamma-Glutamyltransferase
Zur Frage der Nebenwirkungen von alpha-Methyldopa auf die Leber.