Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.
The effects of new thienodiazepine derivatives, such as clotiazepam and Y-7131, on normal human sleep were investigated on 5 subjects and compared to those of benzodiazepine derivatives, such as diazepam and nitrazepam. REM sleep was significantly decreased only with 2 mg of Y-7131 and rebound elevation of REM sleep did not follow in recovery 1 and 2 nights. By using partial differential REM deprivation which was designed by us, there was also no rebound elevation of REM sleep noted in recovery 2 nights following 2 mg of Y-7131 medication. REM sleep was not suppressed with 15 mg of clotiazepam, 6 mg of diazepam and 10 mg of nitrazepam when compared to the baseline night. With regard to NREM sleep, stage 2 was significantly increased with 15 mg of clotiazepam and 10 mg of nitrazepam, but stage SWS was significantly decreased with 10 mg of nitrazepam.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001381:Azepines / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000494:pharmacology / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D009567:Nitrazepam / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001381:Azepines; D013876:Thiophenes; D014149:Tranquilizing Agents; D009567:Nitrazepam; C044610:etizolam; D003975:Diazepam