The value of complement fixation and haemagglutination inhibition tests in the diagnosis of influenza A.
Antibody response of 133 influenza A patients from three outbreaks since 1972-73 was analyzed by complement fixation (CF) and haemagglutination inhibition (HI) methods. During the first outbreak, a significant response was more often measured by CF than by HI. During the last outbreak HI appeared more useful than CF for routine serological diagnosis; 23% of cases verified by HI were missed by CF. The poor response of CF antibodies was associated with the high level of pre-infection antibodies.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D003168:Complement Fixation Tests; D003937:Diagnosis, Differential; D004196:Disease Outbreaks; D005069:Evaluation Studies as Topic; D005387:Finland; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000175:diagnosis*; D008297:Male; D008887:Military Medicine; D009975:Orthomyxoviridae / Q000276:immunology
D000914:Antibodies, Viral