Effect of carbenoxolone on lipolysis in rat adipose tissue.
Carbenoxolone slightly but significantly decreased the release of FFA from rat epididymal fat pads. The antilipolytic action of carbenoxolone was not blocked by 10(-3)M 3-isobutyl-1-methylxanthine, a potent inhibitor of phosphodiesterase. The findings suggest that carbenoxolone exerts its antilipolytic activity by acting on adenylate cyclase, thereby decreasing cyclic AMP concentrations and the activity of the hormone-sensitive lipase in adipose tissue.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002229:Carbenoxolone / Q000494:pharmacology*; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D051381:Rats; D014315:Triterpenes / Q000494:pharmacology*
D005227:Fatty Acids; D014315:Triterpenes; D003994:Bucladesine; D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D010727:Phosphoric Diester Hydrolases; D002229:Carbenoxolone; D004837:Epinephrine