Modulation of in vitro erythropoiesis. The influence of beta-adrenergic agonists on erythroid colony formation.
Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.
D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D001854:Bone Marrow Cells; D002771:Cholera; D000242:Cyclic AMP / Q000494:pharmacology; D004285:Dogs; D004768:Enterotoxins / Q000494:pharmacology; D004920:Erythropoiesis / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D004768:Enterotoxins; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol