Protective ability of Salmonella ribosomal protein and RNA in inbred mice.
Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J, C3H/HeDub, and C3H/HeJ mice. Purified ribosomal components were also tested as immunogens in the inbred mice. Protein isolated from a Salmonella ribosomal fraction could protect all three mouse strains. Although purified RNA was shown to be protective for A/J and C3H/HeDub mice, it was not protective for C3H/HeJ mice. Protective immunity could be induced in A/J and C3H/HeDub mice by various immunostimulants. Immunity in C3H/HeJ mice, however, could only be induced by Salmonella ribosomes or protein isolated from the Salmonella ribosomal fraction.
D000818:Animals; D007109:Immunity; D007114:Immunization; D005779:Immunodiffusion; D008050:Lipid A / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012335:RNA, Ribosomal / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*; D012270:Ribosomes / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology
D008050:Lipid A; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins