Characteristics of release of duodenal gastrin.
Duodenal gastrin release in the dog was studied after mucosal antrectomy with intact duodenal innervation, following which basal gastrin levels fell. Acetylcholine at pH 7 but not at pH 1.5 and insulin hypoglycemia but not 2-deoxyglucose release duodenal gastrin. Glycine (pH7), physiologic saline (pH 7), and balloon distention failed to release duodenal gastrin. These findings suggest differences in release characteristics between canine antral and duodenal gastrin, and point out species differences between man and dog in respect to release of duodenal gastrin.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D004285:Dogs; D004386:Duodenum / Q000294:innervation / Q000378:metabolism*; D005743:Gastrectomy; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology; D011312:Pressure; D011706:Pyloric Antrum / Q000378:metabolism; D013045:Species Specificity; D013268:Stimulation, Chemical; D014630:Vagus Nerve / Q000187:drug effects
D005755:Gastrins; D007328:Insulin; D003847:Deoxyglucose; D000109:Acetylcholine