[Action of analeptics in acute alcoholic intoxication].
Tests conducted on rabbits in a state of acute ethanol poisoning (2.5 g/kg per os) of a medium degree demonstrated that caffein (10 mg/kg) and bemegride (5 mg/kg) introduced one time intravenously at the height of alcoholic intoxication raise the activity of aerobic oxidative processes, but fail to eliminate metabolic acidosis and do not accelerate the excretion of ethanol. Unlike caffein, bemegride shows a tendency toward respiratory compensation of metabolic acidosis and lowers the activity of the alcohol-dehydrogenase.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000188:drug therapy; D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001534:Bemegride / Q000627:therapeutic use; D002110:Caffeine / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D011817:Rabbits; D013997:Time Factors
D000697:Central Nervous System Stimulants; D002110:Caffeine; D001534:Bemegride
Deĭstvie analeptikov pri ostroĭ alkogol'noĭ intoksikatsii.