[Induction of tyrosine aminotransferase by blastomogenic metabolites of tryptophan and tyrosine].
A comparitive study was made of the effect produced by endogenous blastomogenic agents (3-oxyanthranylic and paraoxphenyl-lactic acids) and their nonblastomogenic anaogues (anthranylic and phenyl-lactic acids) on the activity of tyrosine-aminotranspherase in the rat liver. Blastomogenic metabolites proved to be capable of inducing sharply the enzyme activity. This phenomenon and data on the role played by the increase in the activity of tyrosine-aminotranspherase and tryptophane-oxygenase in tyrosine and tryptophane catabolism on the way of a possible formation of blastomogenic metabolites permitted to put forward a suggestion on the "chain reaction" of accumulation of the endogenous blastomogenic agents in the organism.
D015095:3-Hydroxyanthranilic Acid / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D004790:Enzyme Induction; D007773:Lactates / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D010636:Phenols / Q000494:pharmacology; D051381:Rats; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014444:Tyrosine Transaminase / Q000378:metabolism*; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D002273:Carcinogens; D007773:Lactates; D010636:Phenols; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; D014443:Tyrosine; D014364:Tryptophan; D014444:Tyrosine Transaminase
Induktsiia tirozin-aminotransferazy blastomogennymi metabolitami triptofana i tirozina