Piperazine derivatives of dimethylxanthines. IV. Reaction of beta,gamma-epoxypropyldimethylxanthines with piperazines.
In the reaction of 7-resp. 1-beta,gamma-epoxyproplderivatives of theophylline (Th) or theobromine (Tb) with piperazine and N-monoalkyl or monoarylpiperazines the corresponding 7-resp. 1-beta-hydroxy-gamma-piperazinopropyl-Th (1-8) resp. Tb (9-16) were formed. In preliminary screening some of the new compounds showed strong antagonism with histamine H1 receptor and with endogenous histamine.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004852:Epoxy Compounds; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D013806:Theophylline; D014970:Xanthines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
D004852:Epoxy Compounds; D006634:Histamine H1 Antagonists; D010879:Piperazines; D014970:Xanthines; D013806:Theophylline