[Relationship between hematopoietic stem differentiation and the functional state of the thymus].
The direction of differentiation of the stem cells with respect to the physiological activity of thymus determined by the age of an animal was studied by means of histological analysis of hemopoietic colonies in the spleen of lethally irradiated mice. The immaturity of thymus of its involution are characterized by the inhibition of differentiation of the stem cell along the granuloid path. An analysis of the data on differentiation of the stem cells in mice of different age, as well as in thymectomized mice allows to draw a conclusion that the process of differentiation of the hemopoietic stem cells is thymus-dependent.
D000367:Age Factors; D000818:Animals; D002454:Cell Differentiation; D002999:Clone Cells; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000502:physiology; D013950:Thymus Gland / Q000502:physiology*; D014184:Transplantation, Homologous
Zavisimost' differentsirovki stvolovykh krovetvornykh kletok ot funktsional'nogo sostoianiia timusa.