[Actions of sodium dichloroacetate in combination with insulin on hyperlactatemia and hyperpyruvicemia induced in dogs by phenformin].
In the normal anesthetized dog the combination of insulin, whether of exogenous or endogenous origin, with sodium dichloroacetate provoke a rapid and important reduction of the hyperlactatemia and hyperpyruvicemia induced by the intraduodenal injection of high doses of phenformin. Furthermore this combination prevents the progressive and important lowering of the arterial pH provoked by phenformin.
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000097:blood*; D010629:Phenformin / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*
D000085:Acetates; D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D003999:Dichloroacetic Acid; D010629:Phenformin
Actions du dichloroacétate de sodium associé à l'insuline sur l'hyperlactatémie et l'hyperpyruvicémie provoquées chez le chien par la phenformine.