Structural requirements of imidazole compounds to be inhibitors or activators of histamine methyltransferase: investigation of histamine analogues and H2-receptor antagonists.
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D006632:Histamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006637:Histamine N-Methyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D007536:Isomerism; D008780:Methyltransferases / Q000378:metabolism*; D012995:Solubility; D013329:Structure-Activity Relationship; D013552:Swine
D006635:Histamine H2 Antagonists; D007093:Imidazoles; D006632:Histamine; D008780:Methyltransferases; D006637:Histamine N-Methyltransferase