Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules.
The authors have studied the effect of the suspension of chronic treatment with flurazepam and amobarbital on the operant behavior of rats that for the first time were in the presence of two fixed-interval discrimination schedules. With the sound discrimination schedule, the responses emitted by the treated animals had charactistics similar to those of control animals. With the temporal discrimination schedule, though it is not possible to distinguish between learning rates, modifications in the intensity of the effect (increases in lever pressing) indicate that, considering the doses, the action of flurazepam is slight and that of amobarbital clear and statistically significant.
D000161:Acoustic Stimulation; D000654:Amobarbital / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects; D005479:Flurazepam / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000654:Amobarbital; D005479:Flurazepam