Selective blocking properties of chloro acetyl catechol (CAC) on the alpha-adrenergic receptor.
In anesthetized rats and cats chloro acetyl catechol (CAC, 10 mg/kg i.v. and 10-15 mg/kg i.v., respectively) selectively blocked the arterial hypertensive responses to epinephrine. No adrenergic blockade was produced by CAC in rats pretreated with 20 mg/kg i.p. of the compound 24 hr before the experiment. Norepinephrine-induced contractions of the rat vas deferens and the rat seminal vesicles in vitro were blocked by CAC 10(-4) M. The blockade was prevented by the simultaneous addition of norepinephrine or cysteine. The data are discussed in relation to : (a) the nature of the adrenergic blockade produced by CAC and (b) the possible existence of thiol groups in the vicinity of the active site of the alpha-adrenergic receptor.
D000317:Adrenergic alpha-Antagonists; D000818:Animals; D002396:Catechols / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012669:Seminal Vesicles / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D002396:Catechols; D011941:Receptors, Adrenergic