[Changes in the urinary excretion of gamma-glutamyltranspeptidase, leucine aminopeptidas and alkaline phosphatase in the combined action of ethylene glycol and high temperature].
Gamma-glutamyl transpeptidase (gamma--GTP), leucine aminopeptidase (LAP) and alkaline phosphatase (AP) excretion in rats is followed in dynamics (2, 8, 15, 30 and 90 days) upon isolated and combined treatment with ethylene glycol (EG) at dose 1/8 LD50 and temperature of the environment 35 degrees C. Under the effect of high temperature an increase in the excretion of enzymes in the early observation terms is noted. The independent application of the noxa causes a reduction in gamma--GTR and LAP excretion, and an increase in AP. The temperature factor attenuates the toxic effect of EG relative to the enzymes under study at the end of the observation period. Changes in gamma--GTP excretion are considered as the earliest and most sensitive sign of tubular lesions.
D000469:Alkaline Phosphatase / Q000652:urine*; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D005026:Ethylene Glycols / Q000633:toxicity*; D007931:Leucyl Aminopeptidase / Q000652:urine*; D008297:Male; D051381:Rats; D013696:Temperature; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000652:urine*
D005026:Ethylene Glycols; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase
Promeni v ekskretsiiata na gama-glutamiltranspeptidazata, levtsinaminopeptidazata i alkalnata fosfataza v urinata pri kombinirano deĭstvie na etilenglikol i visoka temperatura.