Studies of the pain produced by mafenide acetate preparations in burns.
In a double-blind triple cross-over clinical study, 37 patients were exposed to several formulations of mafenide acetate (Sulfamylon Cream) and their pain responses were recorded and converted to a semiquantitative pain index. The 11.2% concentration in cream was two to three times more painful than the 5% concentration. Hypertonicity  and not the pH level appears to be the cause of the pain produced by the high (11.2%) concentration. The tonicity of the cream carrier and 11.2% mafenide acetate are 1,080 mOsm/kg and 1,100 mOsm/kg, respectively, for a total of 2,180 mOsm/kg. The carrier cream without glycerol and a 5% concentration of mafenide cream were much less painful than the 11.2% concentration of mafenide. Both afforded a great deal of relief to the patients who received the medications.
D000287:Administration, Topical; D000293:Adolescent; D002056:Burns / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D005990:Glycerol; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008272:Mafenide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D009823:Ointment Bases; D009824:Ointments; D010146:Pain / Q000139:chemically induced*; D012965:Sodium Chloride / Q000627:therapeutic use; D012996:Solutions; D013449:Sulfonamides / Q000009:adverse effects*
D009823:Ointment Bases; D009824:Ointments; D012996:Solutions; D013449:Sulfonamides; D012965:Sodium Chloride; D008272:Mafenide; D005990:Glycerol