[Relationship between the quality of the inoculum material and carminomycin biosynthesis by a culture of Actinomadura carminata].
The effect of the inoculum mycelium quality on carminomycin biosynthesis by Actinomadura carminata was studied. The time of the organism growth on the culture medium containing cornsteep liquor continued for 6 hours without losing by the inoculum of its seeding qualities during that period. The mycelium growth in the inoculum was more intensive under conditions of moderate aeration, i.e. 0.98-2.64 mg O2H1-min. Anincrease in the aeration rate up to 18.56 mg O2/1-min resulted in the growth suppression up to 40 per cent. No correlation between the aeration rate during the inoculum growth and the culture capacity for carminomycin biosynthesis and of the content of the complex in active components the fermentation medium were observed, when a 5-10 per cent of inoculum was used.
D000192:Actinomycetales / Q000378:metabolism*; D000388:Air; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002360:Carubicin / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration
D000903:Antibiotics, Antineoplastic; D002360:Carubicin; D005947:Glucose
Zavisimost' biosinteza karminomitsina kul'turoĭ Actinomadura carminata ot kachestva posevnogo materiala.