[Possible neuropharmacological regulation of chemical carcinogenesis caused by diethylnitrosamine].
The effect of a number of neurotropic drugs on diethylnitrosoamine (DENA)-induced chemical carcinogenesis was studied by applying pharmacological, morphological and biochemical techniques. Atropine stimulated significantly the rat liver and esophagus carcinogenesis, whereas the alpha-adrenoblocking agent, a pyrrhoxane analogue, and, particularly, proserine inhibited these processes. All animals treated with DENA demonstrated a significant increase of liver mitochondrial monoaminoxidase activity. These findings as well as the evidence of a stimulating effect of exogenous norepinephrine on carcionogenesis, together with the literature sources on carcinogenic and modifying carcinogenesis action of neurotropics allow the authors to formulate a concet of the trigger role played by catecholamines in the DENA-induced cell transformation and carcinogenesis.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004052:Diethylnitrosamine; D004146:Dioxanes / Q000494:pharmacology; D004347:Drug Interactions; D004938:Esophageal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008930:Mitochondria, Liver / Q000201:enzymology; D008995:Monoamine Oxidase / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013268:Stimulation, Chemical
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D009602:Nitrosamines; D011759:Pyrrolidines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D004052:Diethylnitrosamine; D001285:Atropine; D012110:Reserpine; D008995:Monoamine Oxidase
O vozmozhnosti neĭrofarmakologicheskoĭ reguliatsii khimicheskogo kantserogeneze, vyzvannogo diétilnitrozaminom.