[Iskedyl and general anesthesia. Measurement of the systolic ejection volume and peripheral resistance using the arterial pressure curves].
ISKEDYL (PF 50), which is sold as a vasoregulator of cerebral irrigation, consists of a mixture of dihydroergocristine and raubasine. This work aims at determining possible interactions between this product and certain drugs used in anesthesia from the cardiovascular point of view. ISKEDYL does not seem to be a contraindication to anesthesia of the "neuroleptic" type, when injected in pre-, per- or post-operative period. A slight temporary and spontaneously reversible fall in arterial blood pressure, affecting both maximum and minimum pressure, together with a decrease in stroke volume and peripheral resistances, estimated by the study of the arterial blood pressure curve, seem to indicate that this product has peripheral vaso-dilatory properties.
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004338:Drug Combinations; D004562:Electrocardiography; D004877:Ergoloid Mesylates / Q000494:pharmacology*; D006801:Humans; D014655:Vascular Resistance / Q000187:drug effects*; D014666:Vasomotor System / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology*
D004338:Drug Combinations; D004088:Dihydroergotoxine; D015016:Yohimbine; D004877:Ergoloid Mesylates; C008171:dihydroergotoxine, raubasine drug combination
Iskedyl et anesthésie générale. Mesure du volume d'éjection systolique et des résistances périphériques par l'étude de la courbe de pression artérielle