[Cyclic AMP and plasma renin activity in renal vein blood after amitryptiline, theophylline, furosemide and beta adrenergic blocking substances (author's transl)].
The influence of amitryptiline, theophylline and furosemide on the concentration of cyclic-AMP and plasma renin activity (PRA) was investigated in renal vein plasma. Additionally, the stimulating effect of furosemide on the PRA after application of the beta-adrenergic receptor antagonists propranolol and practolol and the cyclic AMP concentration in the plasma were measured. All drugs were given intravenously. After amitryptiline cyclic-AMP concentration increased about 1.5-fold compared with the basal value,PRA was not altered. After theophylline cyclic-AMP concentration increased about 1.2-fold, PRA 2.0-fold compared with the basal value, PRA was not altered. After theophylline cyclic-AMP concentration increased about 1.2-fold, PRA 2.0-fold coa increased within 7 min and no further increase was observed till the 15th min. After practolol cyclic-AMP concentration and PRA decreased about 20% compared with the basal value within 10 min. The stimulating effect of subsequently applied furosemide on PRA was not altered, but the cyclic-AMP concentration was not changed in this time by furosemide. After propranolol cyclic-AMP concentration and PRA decreased about 20% compared with the basal value. The cyclic-AMP concentration was not influenced by the following furosemide application, in agreement with the findings after practolol, however, PRA could be stimulated only in 36% of these patients under beta-receptor blockade. Our results show that changes of the concentrations of cyclic-AMP and of PRA are independent of each other. An elevated intracellular cyclic-AMP level due to the inhibition of phosphodiesterase is as a single factor unable to stimulate renin release. Our results give no evidence of a direct involvement of the adenylcyclase-system in the mechanism of renin release. The effect of propranolol and practolol on the basal value of PRA and cyclic-AMP is equal. The different influence of 10 mg propranolol and 20 mg practolol on the stimulating effect of 40 mg furosemide on the PRA can be interpreted as a dosage problem.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000639:Amitriptyline / Q000494:pharmacology*; D000242:Cyclic AMP / Q000097:blood*; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012082:Renal Veins; D012083:Renin / Q000097:blood* / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D000639:Amitriptyline; D005665:Furosemide; D011433:Propranolol; D013806:Theophylline; D000242:Cyclic AMP; D012083:Renin; D011217:Practolol
Zyklisches AMP und Reninaktivität im Nierenvenenplasma nach Amitryptilin, Theophyllin, Furosemid und beta-adrenergen Rezeptorantagonisten