Inhibition of bovine renal adenylate cyclase by urinary products.
The secondary hyperparathyroidism in uremic patients is due to the modification plasma electrolyte concentrations accompanied by a renal resistance to PTH action. We postulate that the retention of a uremic toxin could be at least partly responsible for this resistance. We have tested this hypothesis "in vitro" by measuring the action of Middle Molecules on the adenylate cyclase activity stimulated by NaF, PTH and isoproterenol.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000652:urine*; D005459:Fluorides / Q000037:antagonists & inhibitors; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006962:Hyperparathyroidism, Secondary / Q000503:physiopathology*; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D007668:Kidney / Q000503:physiopathology; D007672:Kidney Cortex / Q000201:enzymology*; D008970:Molecular Weight; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology; D006435:Renal Dialysis; D014511:Uremia / Q000652:urine*
D000067956:Adenylyl Cyclase Inhibitors; D004791:Enzyme Inhibitors; D010281:Parathyroid Hormone; D007545:Isoproterenol; D005459:Fluorides