Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee.
The saluretic and uricosuric responses elicited by a novel agent, MK-196, have been studied in a great ape, the chimpanzee. This agent is orally active at very low doses and has a prolonged duration of action. Probenecid does not appear to influence the saluretic and uricosuric properties of MK-196. Net tubular secretion of urate was reduced by MK-196. Urinary pH changes did not compromise the efficacy of this new agent. On a dose basis, MK-196 was more saluretic (and uricosuric) than ethacrynic acid or furosemide and possessed a longer duration of action. Because of the marked natriuresis caused by MK-196, some increase in potassium excretion occurred.
D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004347:Drug Interactions; D004976:Ethacrynic Acid / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D008634:Mersalyl / Q000494:pharmacology; D002679:Pan troglodytes / Q000378:metabolism*; D011188:Potassium / Q000652:urine; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D012965:Sodium Chloride / Q000652:urine*; D013268:Stimulation, Chemical; D013997:Time Factors; D014527:Uric Acid / Q000652:urine; D014528:Uricosuric Agents; D010130:p-Aminohippuric Acid / Q000494:pharmacology
D007189:Indans; D007192:Indenes; D014528:Uricosuric Agents; D014527:Uric Acid; D012965:Sodium Chloride; D008634:Mersalyl; D005665:Furosemide; D004976:Ethacrynic Acid; D011339:Probenecid; D011188:Potassium; D010130:p-Aminohippuric Acid