Effect of oxotremorine and sodium pentobarbitone on the pharmacokinetics of intravenous tracer doses or radioactive choline.
The present study explains for the previous findings that oxotremorine increases and sodium pentobarbitone decreases the initial brain uptake of intravenously injected radioactive choline (3H-Ch). The effects are explained by haemodynamic changes since a corresponding increase and decrease in the plasma concentrations of 3H-Ch were found. This is important to know when 3H-Ch is used for estimation of aceytlcholine turnover in the brain. The drugs did not affect the distribution of radioactivity (3H) between plasma and erythrocytes.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002794:Choline / Q000097:blood / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D013997:Time Factors
D010095:Oxotremorine; D001285:Atropine; D010424:Pentobarbital; D002794:Choline