[Demonstration of N-acetylgalactosaminyltransferase activity in the murine lymphoma YC8].
The N-acetyl-galactosaminyltransferase activity has been studied in the biological fluids of YC8-lymphoma bearing Balb/c mice. It is enhanced during tumor development from 1 to 30 times in peritoneal fluids and from 1 to 10 times in sera. This activity is nil in urines. Optimal requirements for activity have been determined. Results suggest the existence, during tumor process not only of an enhancement of enzymatic activity, but also of a new molecule synthesis, molecules which are endogenous acceptors for the enzyme.
D000818:Animals; D001202:Ascitic Fluid / Q000201:enzymology; D002413:Cations, Divalent; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006602:Hexosyltransferases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008223:Lymphoma / Q000201:enzymology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology; D013997:Time Factors
D002413:Cations, Divalent; D006602:Hexosyltransferases; D005646:Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase
Mise en évidence d'une activité N-acétyl-galactosaminyltransférase au cours du lymphome murin YC8.