[Effect of some phenothiazine derivatives on kidney function].
Chlorathizin and Chlormorphathizin are shown to exercise in 24-hours long tests a substantial diuretic and saluretic action on rats and dogs. Fluorathizin, as well as imizine inhibited the urinary flow. Diprazine augmented the urinary output in dogs, but depressed it in rats. The new antidepressive drug azaphen did not have any marked effect on the urinary flow.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002940:Circadian Rhythm; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010078:Oxazines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014554:Urination / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010078:Oxazines; D010879:Piperazines; D012964:Sodium; D011398:Promethazine; D007099:Imipramine; D011188:Potassium
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