Brain microvascular hemodynamic responses to induced seizures.
Arteriolar diameters and venular erythrocyte velocities in the small pial vessels on the surface of the cat brain were measured by TV methods during induced epileptic seizures through a cranial window. Grand mal seizures maximally dilated arterioles and increased venular erythrocyte velocity up to 400%. High positive correlation existed between changes in CSF hydrogen ion concentration and pial arteriolar diameter, suggesting metabolic regulation of CBF through CSF/interstitial fluid hydrogen ion alterations during the seizure.
D000818:Animals; D001794:Blood Pressure; D002415:Cats; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D004737:Enflurane; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid / Q000139:chemically induced / Q000503:physiopathology; D006863:Hydrogen-Ion Concentration; D008833:Microcirculation; D010433:Pentylenetetrazole
D004737:Enflurane; D010433:Pentylenetetrazole