Amiodarone-like haemodynamic and non-competitive antiadrenergic properties of a benzoyl-indolizine.
1. 2-Ethyl-3-(4-gamma-di-n-butylaminopropoxy-benzoyl)-indolizine hydrochloride (L 9394) induced in the ananesthetized dog a marked and long-lasting decrease in heart rate together with a transient reduction in blood pressure. 2. L 9394 decreased Robinson's index, an effect which suggests that the substance reduces the oxygen requirements of the heart. 3. L 9394 markedly increased coronary arterial blood flow. 4. L 9394 is endowed with non-competitive antiadrenergic properties. 5. L 9394 did not impair cardiac function since cardiac output and stroke volume increased appreciably during the initial phase of action and did not fall below the control values at any time thereafter. 6. The overall haemodynamic properties of L 9394, which were similar to those of amiodarone, are considered to be potentially valuable for the long-term treatment of angina pectoris.
D000319:Adrenergic beta-Antagonists; D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007212:Indolizines / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D013565:Sympatholytics
D000319:Adrenergic beta-Antagonists; D007212:Indolizines; D011437:Propylamines; D013565:Sympatholytics; D005934:Glucagon; D011433:Propranolol; D000638:Amiodarone