[Comparative experimental studies in animals and humans on gastrointestinal blood loss following antirheumatic pharmacotherapy (author's transl)].
The gastrointestinal blood loss caused by the two antirheumatic drugs acetyl salicylic acid (ASA) and 4-acetamidophenyl-2-acetoxybenzoate (benorilate, Benortan) was compared in experimental animals and humans by measuring the total body iron retention. In Wistar rats and humans the results indicate that the daily iron loss under ASA is significantly higher (almost by the factor 2) than that under benorilate.
D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007501:Iron / Q000378:metabolism; D007504:Iron Radioisotopes; D008297:Male; D051381:Rats; D012459:Salicylates / Q000009:adverse effects*; D013997:Time Factors
D007504:Iron Radioisotopes; D012459:Salicylates; D007501:Iron; D001241:Aspirin
Vergleichende tierexperimentelle und humanmedizinische Untersuchungen über gastrointestinalen Blutverlust bei der antirheumatischen Pharmakotherapie.