Application of orthogonal functions to the spectrophotometric determination of phenytoin and phenobarbitone in pharmaceutical preparations.
Orthogonal polynomial functions have been used in the simultaneous determination of mixtures of phenytoin and phenobarbitone in pharmaceutical preparations. The mean recovery (9 determinations) and coefficeint of variation were 100-0 +/- 1-4% for phenobarbitone and 100-0 +/-1-3% for phenytoin. Neither the delta A method of Pannerdan & Fontein nor a delta A modification of Vierordt's method of two-component analysis gave results of the same accuracy and precision as the proposed method.
D002214:Capsules / Q000032:analysis; D004338:Drug Combinations; D008722:Methods; D010634:Phenobarbital / Q000032:analysis*; D010672:Phenytoin / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013223:Statistics as Topic
D002214:Capsules; D004338:Drug Combinations; D010672:Phenytoin; D010634:Phenobarbital