Penicillin combinations against multi-resistant urinary pathogens as an alternative to gentamycin treatment.
A total of 42 multi-resistant urinary pathogens, sensitive to gentamycin only, were investigated with regard to the effects of dicloxacillin and ampicillin or cloxacillin/flucloxacillin and amoxycillin in combination. A synergistic antibiotic effect with resulting low MIC levels was demonstrated for 81% of the strains. It was also found that a further increase in sensitivity might be achieved by adjustment of the pH level.
D000658:Amoxicillin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D003023:Cloxacillin / Q000494:pharmacology; D004009:Dicloxacillin / Q000494:pharmacology; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects*; D005436:Floxacillin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000382:microbiology*
D005839:Gentamicins; D010406:Penicillins; D005436:Floxacillin; D000667:Ampicillin; D000658:Amoxicillin; D004009:Dicloxacillin; D003023:Cloxacillin