Effect of parathyroid hormone on urinary acidification.
The effect of parathyroid hormone (PTH) administration on urinary acidification was studied in intact and thyroparathyroidectomized dogs. PTH administration resulted in a significant increase in urine pH and HCO3 excretion. In dogs with maximally acid urine caused by Na2SO4 infusion PTH administration also led to a significant increase in urine pH and to a decrease in ammonium excretion. To examine the effect of PTH on H+ secretion in the distal nephron we measured the urine-blood (U-B) PCO2 gradient in dogs with maximally alkaline urine (urine pH greater than 7.8) before and after PTH administration. After infusion of the hormone, HCO3 excretion increased significantly but the U-B PCO2 gradient remained unchanged. The effects of PTH infusion on urinary acidification in animals with distal renal tubular acidosis caused by LiCl administration were also studied. PTH administration to these dogs increased HCO3 excretion to the same level seen in normal dogs. These data suggest that PTH does not inhibit distal H+ secretion but increases HCO3 excretion by depressing proximal HCO3 reabsorption.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000641:Ammonia / Q000652:urine; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology / Q000652:urine*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006859:Hydrogen / Q000652:urine; D006863:Hydrogen-Ion Concentration; D007684:Kidney Tubules / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000494:pharmacology; D013965:Thyroidectomy
D001639:Bicarbonates; D010281:Parathyroid Hormone; D010710:Phosphates; D000641:Ammonia; D006859:Hydrogen; D008094:Lithium; D012964:Sodium; D011188:Potassium