Oral cocaine: plasma concentrations and central effects.
Cocaine (2.0 milligrams per kilogram) given by the oral route is at least as effective as the same dose given intranasally. Cocaine is not detected in the plasma until 30 minutes after oral administration, but peak plasma concentrations are similar after both routes. The subjective "highs" in man are greater after oral than after intranasal administration.
D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D003042:Cocaine / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D005059:Euphoria / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D008297:Male; D013997:Time Factors
D003042:Cocaine