Comparison of atenolol and propranolol during insulin-induced hypoglycaemia.
The effects of atenolol, a new beta1-blocking drug, on pulse rate, sweating, and blood glucose levels during insulin-induced hypoglycaemia were studied in a double-blind crossover trial in eight normal subjects using placebo and propranolol as reference agents. The intensity of induced hypoglycaemia was identical for atenolol, propranolol, and placebo. Propranolol prolonged hypoglycaemia, but atenolol did not. Atenolol may therefore be safe for use in patients receiving insulin.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D001786:Blood Glucose; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010919:Placebos; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D013546:Sweating / Q000187:drug effects; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D007328:Insulin; D010919:Placebos; D011412:Propanolamines; D001262:Atenolol; D011433:Propranolol