Passive serum sickness in the mouse: the role of vasoactive amines in glomerular deposition of immune complexes.
This paper reports a study of the importance of vasoactive amines in glomerular localization of passively administered immune complexes in the mouse. Two strains of mice were investigated, one sensitive and the other relatively resistant to the anaphylactogenic effect of intravenously administered immune complexes. The effect on glomerular deposition immune complexes in animals of both strains treated with either vasoactive amine depletors or antagonists leads to the conclusion that in this experimental system vasoactive amines do not play a major part in the glomerular localization of immune complexes.
D000707:Anaphylaxis; D000818:Animals; D000936:Antigen-Antibody Complex; D002744:Chlorpheniramine / Q000494:pharmacology; D006632:Histamine / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007668:Kidney / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D011113:Polymyxins / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists; D012713:Serum Sickness / Q000503:physiopathology*
D000936:Antigen-Antibody Complex; D006634:Histamine H1 Antagonists; D011113:Polymyxins; D012702:Serotonin Antagonists; D012701:Serotonin; D002744:Chlorpheniramine; D006632:Histamine; D012110:Reserpine; D008784:Methysergide