[Wet dog shake behavior in normal rates, elicited by benzylideneaminooxycarbonic acid derivatives].
Wet dog shake (WDS) behavior in rats, well known as morphine-withdrawal syndrome, could be elicited without concomitant symptoms for the first time chemically in non-morphine-addicted animals. The capability to produce WDS was correlated with a specific chemical structure among the title-compounds. The threshold-dose of the most effective agents was 25-50 mg/kg, rather independent of the mode of application. Maximal response of 10-20 WDS per min and animal were reached after application of 100-200 mg/kg. WDS behavior appeared within the first minutes after dose and lasted up to several hours. Detailed information is given on WDS-action of the substance Sgd 8473 = alpha [(4chlorobenzylideneamino)-oxy]-isobutyric acid and the influence by different pharmacologie agents thereon. Inhibition of WDS was produced by: narcotic analgesics, narcotic antagonists, psychosedativ drugs, yohimbine, dl-amphetamine, cocaine, apomorphine and clonidine. Without influence on WDS were: physostigmine, atropine, ganglionic- or adrenergic-blocking drugs, Dopa, MAO-inhibitors, serotonin- and histamin-antagonists and nonnarcotic analgesics. To some extent chemically induced WDS seemed to be susceptible like precipitated WDS. So Sgd 8473 could be qualified for differentiating narctic analgesics, for a "quasiabstinence" agent in research of dependence mechanisms and for a tool in neuroanatomical studies of the CNS.
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002264:Carboxylic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D006877:Hydroxamic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007928:Lethal Dose 50; D009021:Morphine Dependence / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced*
D000701:Analgesics, Opioid; D002087:Butyrates; D002264:Carboxylic Acids; D006877:Hydroxamic Acids; D011619:Psychotropic Drugs; C012670:alpha-((4-chlorobenzylideneamino)oxy)isobutyric acid
Benzylidenaminooxy-carbonsäurederivate als auslöser von "wet dog shake" - verhalten bei normalen ratten