Clinical significance of an increased or decreased serum alkaline phosphatase level.
An increase in the level of serum alkaline phosphatase (ALP) may be caused by a wide variety of pathologic lesions that involve multiple organs, since the enzyme is an ubiquitous one. Before one attempts to identify a significant pathologic abnormality, the clinician should consider the possibility of a physiologic or spurious cause for an increased level of ALP. A decreased ALP level also has diagnostic value.
D000367:Age Factors; D000469:Alkaline Phosphatase / Q000097:blood*; D001847:Bone Diseases / Q000175:diagnosis; D004796:Clinical Enzyme Tests; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D006331:Heart Diseases / Q000175:diagnosis; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007674:Kidney Diseases / Q000175:diagnosis; D007931:Leucyl Aminopeptidase / Q000032:analysis; D008107:Liver Diseases / Q000175:diagnosis; D008171:Lung Diseases / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis; D009708:Nucleotidases / Q000032:analysis; D011247:Pregnancy; D012016:Reference Values; D013158:Splenic Diseases / Q000175:diagnosis; D005723:gamma-Glutamyltransferase / Q000032:analysis
D007527:Isoenzymes; D005723:gamma-Glutamyltransferase; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase