Cytomegalovirus infections in the human population.
Diagnostic and clinical experience gained in the period from 1966--1977 is summarized. Cytomegalovirus was isolated from 35 sucklings and 5 infants aged more than 1 year as well as from necropsy materials from 10 sucklings. The most frequently involved were the respiratory tract (77.8%), liver (53.5%) and haematopoetic apparatus (42.2%). Congenital defects were found in 22.2%. The incidence in the population varied from 20% in sucklings to 50--60% in persons aged over 40 years. The incidence of infection was higher in sucklings and infants in nurseries. Out of 37 adult patients with kidney transplantation, the virus was isolated from 10 (27%) and complement-fixing antibodies were found in 34 (91%) patients.
D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D003604:Czechoslovakia; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation; D012959:Socioeconomic Factors
D000914:Antibodies, Viral