"Genital dyscrinism" as a cause of subfertility in mice of the CBA strain.
Following four generations of inbred mating (brother-sister) in three direct lineages of CBA strain mice, sterility appeared which from that generation forward became more frequent. The genital organs in animals of both sexes were altered. There was a noticeable occurrence of cysts in the ovaries of female animals already following the third month; in mice approximately one year of age this condition was followed by cystic glandular hyperplasia of the endometrium, sometimes complicated by disturbances in blood circulation, inflammation or even malignancy. In some female animals, manifesting, due to cysts, completely degenerated ovaries, the rest of the genital system was severely atrophic. Male animals frequently showed severe atrophy of the seminiferous epithelium along with preserved interstitial cells and hypertrophic seminal vesicles. These pathological changes represent an independent nosologic unit, for which the label "genital dyscrinism" has been proposed. The authors have considered an endocrine mechanism as the possible cause of these pathological changes which are presumed to be genetically conditioned.
D000818:Animals; D004700:Endocrine System Diseases / Q000150:complications* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D005835:Genitalia / Q000473:pathology*; D007246:Infertility / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010053:Ovary / Q000473:pathology; D013737:Testis / Q000473:pathology; D014599:Uterus / Q000473:pathology