Relationships between chemical structure and antiviral activity of some biguanide derivatives.
The aim of this report was to indicate the correlation between chemical structure and antiviral activity of some biguanide derivatives obtained according to Monsanto Chemicals Ltd. Neth. Appl. 289. 283. The studies were carried out on the culture of monkey kidney cells infected with parainfluenza Sendai virus and on the mice infected with influenza virus. The increase of antiviral activities of N-Phenylbiguanide and N-p-Ethoxyphenylbiguanide was estimated.
D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D000882:Haplorhini; D006863:Hydrogen-Ion Concentration; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014776:Virus Cultivation
D001645:Biguanides