In vivo and in vitro activation of T-antigen receptors on leukocytes and platelets.
Serological studies on a patient whose red cells are polyagglutinable due to T activation have demonstrated concomitant T activity of the separated leukocytes and platelets. Normal leukocytes and platelets are not T active, but activation can be induced in vitro by treatment with neuraminidase or with pneumococcus type III filtrate. Such T-active cells absorb anti-T from Arachis hypogea lectin. Tests on idfferent types of separated leukocytes show that both neutrophils and lymphocytes have latent T antigen receptors. Neuraminidase treatment of platelets does not change their ability to promote clot retraction, to aggregate with ADP, or to take up serotonin.
D000042:Absorption; D000906:Antibodies / Q000032:analysis; D001666:Binding Sites, Antibody; D001780:Blood Coagulation Tests; D001789:Blood Group Antigens; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology*; D010206:Papain / Q000494:pharmacology; D010974:Platelet Aggregation; D011955:Receptors, Drug; D012701:Serotonin / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000276:immunology
D000906:Antibodies; D001789:Blood Group Antigens; D037102:Lectins; D011955:Receptors, Drug; D012701:Serotonin; D010206:Papain