Two weeks' treatment with chlorpromazine, thioridazine, sulpiride, or bromazepam: actions and interactions with alcohol on psychomotor skills related to driving.
Subacute effects of C, T, S, or B, alone or in combination with A, were tested against P in two double-blind crossover trials with 37 healthy students. The drugs were given in capsules t.i.d. for 2 weeks each and the psychomotor performance (choice reaction, coordination, attention) was measured on the 7th and 14th days of treatment. At each session the subjects swallowed a capsule together with 0.5 g/kg of A or P drink, and the measurements were done, 30, 90, and 150 min thereafter. T alone did not differ from placebo in the doses used (10 mg t.i.d. for 7 days and 20 mg t.i.d. for the next 7 days). After C (dosing as above) and S (50 mg t.i.d.) both reactive and coordinative skills were slightly impaired. B (6 mg t.i.d.) clearly impaired both reactive skills and attention. T + A had no major combined effect on skills while C interacted with A resulting in impaired reactive and coordinative skills. After C + A the subjects were unable of compensating their coordination mistakes by slow driving. The interaction of S with A was mild, whereas B + A strongly impaired coordination and divided attention. No alterations were recorded in flicker fusion after any treatment.
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving; D001960:Bromazepam / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D009048:Motor Skills / Q000187:drug effects; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects*; D013469:Sulpiride / Q000494:pharmacology*; D013881:Thioridazine / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D010919:Placebos; D000431:Ethanol; D013469:Sulpiride; D013881:Thioridazine; D002746:Chlorpromazine; D001960:Bromazepam