[Induction of hepatic tyrosine transaminase in rats by phenothiazine derivatives and analogs].
We have showed induction of tyrosine-alpha-ketoglutarate transaminase in hepatic cytosol of Rats (Wistar strain) five hours after intraperitoneal administration of tricyclic compounds (phenothiazine, iminodibenzyl, thioxanthene, thiophenylpyridylamin, dibenzocycloheptadiene, dibenzoxepin derivatives). Chemical structure of these molecules is very important: sulfur atom (phenothiazine, thioxanthene), some substituants like chlorine (chlorpromazine, chlorprothixene) and 2'-dimethylaminopropyl chain (promethazine) increase this inductive effect.
D000818:Animals; D003984:Dibenzazepines / Q000494:pharmacology; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D003990:Dibenzoxepins / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000494:pharmacology; D013892:Thioxanthenes / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D003984:Dibenzazepines; D003986:Dibenzocycloheptenes; D003990:Dibenzoxepins; D010640:Phenothiazines; D013843:Thiazines; D013892:Thioxanthenes; D014444:Tyrosine Transaminase
Induction de la tyrosine-transaminase de foie de rat sous l'effet de dérivés phénothiaziniques et chimiquement apparentes.