[Constant outflow anesthesia with the combination of alfatesine and fentanyl].
In a previous work, the authors showed the value of administering Alfatesine, in interventions of long duration, at a constant rate by using an automatic syringe, and by combining it with destromoramide. In this new work the authors present an analagous study carried out in 47 subjects, in which dextromoramide was replaced by fentanyl. The automatic syringe used was the Braun Perfusor IV equipped with a 50 ml syringe containing 0.3 ml. of CT 13.41 and 0.006 mg. of fentanyl per ml. Induction was achieved at graduation 10, 14 ml of the mixture having been injected in approximately 60 seconds. Maintenance of anesthesia was ensured at graduation 6 corresponding to an hourly administration of 27 to 30 ml of the mixture (9 ml of CT 13.41 and 0.18 mg of fentanyl). The patients were adults of average weight 64 kg., who had undergone sometimes major orthopedic surgery, of an average duration of 161 mn. The results are looked at from the angle of quality of the anesthesia and of the awakening and of the side effects. They confirm the non-accumulation under these conditions of use and these doses of CT 13.41 used and reveals an analagous behaviour of fentanyl. Reserves are however made owing to the mode of elimination of fentanyl, on the use of such a technique in anuric patients or in renal insufficiency.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology; D000768:Anesthesia, General / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D003916:Dextromoramide; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines / Q000009:adverse effects; D011277:Pregnanediones / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects
D004338:Drug Combinations; D010627:Phenethylamines; D011277:Pregnanediones; D000530:Alfaxalone Alfadolone Mixture; D003916:Dextromoramide; D005283:Fentanyl
Anesthésie à débit constant par l'association alfatésine-fentanyl