A comparison of the effects of the inhalation of 4% and 8% fluroxene in the pregnant primate.
A comparison was made of the effects of inhalation of 4% fluroxene (n = 5) and 8% fluroxene (n = 5) in pregnant monkeys. Measurements of maternal arterial blood pressure, heart rate, cardiac output, total peripheral resistance, uterine blood flow, fetal heart rate and arterial blood pressure, and maternal and fetal blood gas levels were made. Inhalation of 4% fluroxene for 20 minutes produced little change in maternal hemodynamics and was well tolerated by the fetus. Fluroxene 8% inhaled for a similar 20-minute-period produced a significant decrease in maternal blood pressure (--27%), total peripheral resistance (--32%), and uterine blood flow (--27%) and lowered the level of maternal fetal exchange.
D000769:Anesthesia, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D004987:Ethers / Q000494:pharmacology*; D005260:Female; D005318:Fetal Heart / Q000187:drug effects; D005333:Fetus / Q000187:drug effects*; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008251:Macaca; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D014599:Uterus / Q000098:blood supply; D014655:Vascular Resistance / Q000187:drug effects
D004987:Ethers; D002245:Carbon Dioxide; D010100:Oxygen