On the distribution of drugs in saliva and blood plasma.
The equilibration of drug concentrations between blood plasma (unbound part) and saliva was studied for selected drugs with different physicochemical properties: Quinidine, sulfamerazine, paracetamol, diazepam and ethanol. From these and other experimental results it is suggested: 1. The concentration ratio between saliva and blood plasma (unbound) can only equal one for basic drugs with a pK a lower than 5.5 and acid drugs with a pK a higher than 8.5 and for pH indifferent drugs. 2. The drug must have a sufficient permeation ability through lipid membranes, valuable by the lipid water partition coefficient.
D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D011485:Protein Binding; D012463:Saliva / Q000378:metabolism*
D001798:Blood Proteins; D004364:Pharmaceutical Preparations