[Equilibrium system consisting of soluble forms of fibrin and the specific anticoagulant D fragment of the firbinogen molecule].
According to the authors' observations, mixtures of fibrin monomer and fibrinogen-derived D fragment are gradually transformed into an equilibrium system when fibrin exists partly in a solid clot form and partly as a soluble material made unclottable by the influence of fragment D. The amount of such a soluble fibrin proved to be a linear function of the D fragment concentration. Three fibrin monomer preparations obtained in different ways were used. All of them showed similar properties as to the modifications with D fragment. The solubilzing activity of D fragment in the equilibrium system could sharply be raised by increasing ionic strength or pH. It is known that these medium changes produce the same stimulation effect on D fragment, being examined as an inhibitor of fibrin monomer polymerization. But the concentration dependences of the two activities of D fragment differ in principle.
D005337:Fibrin; D005340:Fibrinogen; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046911:Macromolecular Substances; D009994:Osmolar Concentration; D010446:Peptide Fragments
D046911:Macromolecular Substances; D010446:Peptide Fragments; D005337:Fibrin; D005340:Fibrinogen
Rivnovazhna sistema, utvoriuvana rozchinnimi formami fibrinu ta spetsifichnim antikoaguliantom--fragmentom d molekuli fibrinogenu.