[Effect of tetracycline base crystallization on the conditions properties of the powders and drug forms obtained. The development of directed crystallization procedures for tetracycline base].
The study of the process of tetracycline base crystallization showed that with an increase in the rate of pH, temperature and mixed rotation changes, the specific surface of the crystalline precipitate increased with a simultaneous decrease in the bulk weight, looseness and volume density of the powder. The residual content of tetracycline in the mother solution decreased. The level of the effect of various parameters on the final results was different.
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D006863:Hydrogen-Ion Concentration; D008722:Methods; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D011208:Powders; D012107:Research Design; D012996:Solutions; D013696:Temperature; D013752:Tetracycline / Q000494:pharmacology*
D010592:Pharmaceutic Aids; D011208:Powders; D012996:Solutions; D013752:Tetracycline
Vliianie usloviĭ kristallizatsii tetratsiklina osnovaniia na svoĭstva poluchaemykh poroshkov i lekarstvennykh form. Razrabotka priemov napravlennoĭ kristallizatsii tetratsiklina osnovaniia.