Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia.
The effect of synaptic stimulation on tyrosine hydroxylase [tyrosine 3-monooxygenase: L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] activity in the rat superior cervical ganglion was studied. The preganglionic cervical sympathetic trunk was stimulated unilaterally at 10 Hz for 30 min. Forty-eight hours later tyrosine hydroxylase activity was 33% higher on the stimulated than on the control side. The enzyme activity restimulated than on the control side. The enzyme activity remained elevated in the stimulated ganglia for 2 days. No change was observed in total ganglion protein. Comparable increases in tyrosine hydroxylase activity were observed in anesthetized and conscious animals.
D000344:Afferent Pathways / Q000502:physiology; D000758:Anesthesia; D000818:Animals; D004558:Electric Stimulation; D005725:Ganglia, Autonomic / Q000201:enzymology*; D008297:Male; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014851:Wakefulness / Q000502:physiology
D014446:Tyrosine 3-Monooxygenase