Prebiotic peptide-formation in the solid state. III. Condensation reactions of glycine in solid state mixtures containing inorganic polyphosphates.
The reactions of glycine with inorganic polyphosphates in the solid state have been studied. The formation of peptides up to the decamer occurs at moderate temperatures(r.t.-100 degrees C) in the presence of imidazole and magnesium chloride. If adenosine 5' -monophosphate is added to the reaction mixture, 2'(3') -o-glycyl adenosine 5'-monophosphate is also obtained. These reactions could have occurred on the primitive earth.
D000227:Adenine Nucleotides; D000643:Ammonium Chloride; D005075:Biological Evolution; D055598:Chemical Phenomena; D002621:Chemistry; D011756:Diphosphates / Q000138:chemical synthesis; D005998:Glycine / Q000031:analogs & derivatives; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles; D008274:Magnesium; D009842:Oligopeptides / Q000138:chemical synthesis*; D000069497:Origin of Life; D010710:Phosphates; D010879:Piperazines / Q000138:chemical synthesis; D013696:Temperature
D000227:Adenine Nucleotides; D011756:Diphosphates; D007093:Imidazoles; D009842:Oligopeptides; D010710:Phosphates; D010879:Piperazines; D000643:Ammonium Chloride; D008274:Magnesium; D005998:Glycine