Action of atropine on histamine-induced bronchoconstriction in asthmatic children. A pharmacocapnographic study.
In their earlier methodological model studies the authors confirmed the protective effect of atropine in inhalative acetylcholine provocation. In the present work the role of parasympatholysis is investigated in histamine-induced bronchospasm by the method. It was found that a protective effect was exerted in histamine provocation repeated 20 minutes after subcutaneous administration of atropine sulphate in a dose of 0.01 mg/kg. The protective effect proved independent of the individual histamine sensitivities of the patients. The initial value of the CO2 curve prior to provocation was not improved.
D000293:Adolescent; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects*; D001249:Asthma / Q000503:physiopathology*; D001285:Atropine / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects; D002245:Carbon Dioxide / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D006634:Histamine H1 Antagonists; D006801:Humans; D012129:Respiratory Function Tests / Q000295:instrumentation / Q000379:methods; D013997:Time Factors
D000336:Aerosols; D006634:Histamine H1 Antagonists; D002245:Carbon Dioxide; D001285:Atropine; D006632:Histamine