Intracellular acid-base state at a variable temperature in air-breathing vertebrates and its representation.
When temperature changes are superimposed on changes in the control variables of acid-base state (PCO2, strong ion difference), the understanding of acid-base changes becomes difficult. A solution has recently been proposed for blood (Malan, 1977); it was based on the assumption that closed system conditions correspond to a minimal change in the overall acid-base state when temperature varies. The feasibility of extending these concepts to muscle intracellular acid-base vs temperature relationships is evaluated on the basis of a model study; the errors made by replacing closed conditions (which require knowledge of chemical composition) by more convenient approximations are estimated. A representation of both extracellular and intracellular acid-base data on a temperature-corrected bicarbonate-pH diagram is derived. It allows the interpretation of variable-temperature intracellular acid-base changes in terms of changes in control variables, 'respiratory (PCO2) or 'metabolic' (strong ion difference).
D000136:Acid-Base Equilibrium; D000818:Animals; D001790:Blood Physiological Phenomena; D001831:Body Temperature; D002245:Carbon Dioxide / Q000502:physiology; D003201:Computers; D006863:Hydrogen-Ion Concentration; D007424:Intracellular Fluid / Q000502:physiology; D008116:Lizards; D008433:Mathematics; D008954:Models, Biological; D009132:Muscles / Q000502:physiology; D010710:Phosphates / Q000502:physiology; D014426:Turtles
D010710:Phosphates; D002245:Carbon Dioxide