[Aminoacid-p-nitroanilides splitting activities in the mature human placenta (author's transl)].
A long experience in the treatment of endometrial cancer shows that the therapeutic measures vary considerably with regard to the extention of the tumor, the age of the patient and her general condition. This circumstances and particularly the critical study of the therapeutical results give the limits, within a certain kind of operation can reasonably be recommended. The intercurrent deaths are an important factor in the statistical evaluation of therapeutical success. As long as the tumor is limited to the body of the uterus, the corrected 5-year recoveries are about 90%. Considering all the circumstances, it becomes obvious, that in this stage, the simple abdominal hysterectomy with removal of the adnexa is still the operation of choice. Beside the histological degree of differentiation, the depth of the muscular invasion is the most important prognostic factor which might lead to additional measures. Postoperative radiation therapy of the vagina reduces considerably the incidence possibility of vaginal apex recurrence. In stage II radical hysterectomy must be considered, although we are aware of the fact, that a simple hysterectomy and bilateral salpingo-oophorectomy combined with radiation treatment may yield just as good results. In the clinical stage III laparotomy ought to be used more frequently. Also in case of operative intervention additional radiotherapy is mostly useful.
D000596:Amino Acids / Q000378:metabolism; D000626:Aminopeptidases / Q000032:analysis; D002403:Cathepsins / Q000032:analysis; D010122:Cystinyl Aminopeptidase / Q000032:analysis; D010450:Endopeptidases / Q000032:analysis; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009574:Nitro Compounds / Q000378:metabolism; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy
D000596:Amino Acids; D009574:Nitro Compounds; D002403:Cathepsins; D010450:Endopeptidases; D000626:Aminopeptidases; D010122:Cystinyl Aminopeptidase
Aminosäure-p-Nitroanilide spaltende Enzymaktivitäten der reifen menschilchen Plazenta. I.