Inhibitory effect of beta-adrenergic stimulants on the histamine reaction in human skin. I. Studies with fenoterol.
In 20 volunteers histamine inhibition by fenoterol (Th 1165 a) was studied. The wheal and erythema reaction caused by intracutaneous application of 5 mug histamine can be inhibited by applying fenoterol in doses from 100--400 mug in form of a metered aerosol on the skin 5 min before the injection of histamine. In this study the dose-reaction effect yielded on ED50 of 140 mug fenoterol.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D002196:Capillaries / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D006632:Histamine; D006633:Histamine Antagonists; D006801:Humans; D008297:Male; D012867:Skin / Q000098:blood supply*; D012882:Skin Tests
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D006633:Histamine Antagonists; D005280:Fenoterol; D006632:Histamine