Acceleration of nitrosamine formation at pH 3.5 by microorganisms.
Rate enhancements of from 12 to 49-fold occurred when dihexylamine was nitrosated at pH 3.5 in the presence of bacteria and yeast cells at a concentration of 12 mg/ml. Rates were similar in the presence of either boiled or unheated cells. The magnitude of the rate enhancement for nitrosation of other amines depended on the alkyl chain length. A nonenzymatic mechanism involving hydrophobic interactions of the precursor amines and cellular constituents is proposed.
D001407:Bacillus / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D005658:Fungi / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009602:Nitrosamines / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012442:Saccharomycopsis / Q000378:metabolism
D009602:Nitrosamines