Some characteristics of amnesia induced by FLA-63 an inhibitor of dopamine beta hydroxylase.
The amnesic effects of FLA-63, a potent dopamine-beta-hydroxylase (DBH) inhibitor, were investigated in a food motivated spatial discrimination task. Groups of C57BL/6J mice were injected with either 5 mg/kg, 15 mg/kg, 25 mg/kg, 35 mg/kg or physiological saline 4 hr prior to training. Amnesia was observed 24 hr following training at all dose levels except 5 mg/kh. The performance deficit was specific to memory of the discrimination and not the result of state-dependency. Training conditions which produce an increase in habit strength prevented the amnestic effects of FLS-63. Spontaneous recovery of memory occurred 48 hr following drug administration. Recovery from amnesia was also induced by injections of a monoamine oxidase inhibitor, pargyline, administered 2 hr prior to the retention test. These data suggest that amnesia induced by norpinephrine (NE) depletion is the result of impairment of mechanisms necessary for memory retrieval.
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000032:analysis; D010293:Pargyline / Q000494:pharmacology; D013997:Time Factors
D006834:Hydrazines; D007093:Imidazoles; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D010293:Pargyline; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine