Species differences in the in vitro metabolic reduction of the amphetamine metabolite, 1-phenyl-2-propanone.
Marked differences were observed, in the ability of fortified 9000 g liver homogenate supernatants from three species to reduce 1-phenyl-2-propanone to the corresponding alcohol. This metabolic keto-reduction was negligible in homogenates from the rat and extensive in the rabbit; guinea-pig liver homogenates had intermediate ability. Metabolic oxidation of 1-phenyl-2-propanol was negligible in all three species. The amount of deamination of amphetamine and of N-n-propylamphetamine was approximately equal, in vitro, in rats and guinea-pigs but two to three times greater in liver homogenates from rabbits. Approximately three times more deaminated products were formed from the in vitro metabolism of N-n-propylamphetamine than from amphetamine metabolism by all three species.
D000096:Acetone / Q000031:analogs & derivatives; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011427:Propiophenones / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D011427:Propiophenones; D000096:Acetone; C008863:1-phenyl-2-propanone