Comparison of rimiterol and terbutaline, given by aerosol, in a long-term study.
In a double-blind long-term study, regular inhalations of a short-acting selective beta2-stimulator, rimiterol, was compared with a long-acting one, terbutaline. The trial comprised 60 patients with chronic obstructive lung disease, all patients were on a small dose of an oral beta2-stimulator. Both drugs were regularly given in aerosol form with a minimum dose of three inhalations three times daily. The main purpose was to study subjective and objective side effects. Haematological, hepatic and renal functions were screened for toxicity. Consumption of spray was recorded. No side effects occurred. There was no evidence of development of isoprenaline resistance. The consumption of spray was the same in both groups. In this study, regular inhalation treatment of rimiterol seemed to be as effective as terbutaline in long-term bronchodilator therapy.
D000336:Aerosols; D001249:Asthma / Q000188:drug therapy; D001991:Bronchitis / Q000188:drug therapy; D002396:Catechols / Q000008:administration & dosage*; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007545:Isoproterenol; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011656:Pulmonary Emphysema / Q000188:drug therapy; D013726:Terbutaline / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
D000336:Aerosols; D002396:Catechols; D010880:Piperidines; C084590:rimiterol; D007545:Isoproterenol; D013726:Terbutaline