The influence of histamine on epithelial cell proliferation in the jejunum of the rat.
1. The influence of histamine and histamine receptor blockade on the mitotic rate in epithelial cell proliferation in epithelial cells lining the crypts of Lieberkühn in rat jejunum was studied. 2. Histamine injection resulted in an increase in the mitotic rate. This increase in mitotic rate was blocked by metiamide but not by mepyramine. 3. Prevention of histamine synthesis by alpha-methylhistidine administration did not alter the mitotic rate. 4. The mechanism by which histamine may influence crypt cell proliferation and possible role of cyclic GMP in this mediation are discussed.¿
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects*; D006632:Histamine / Q000096:biosynthesis / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007583:Jejunum / Q000166:cytology*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D006632:Histamine