The synthesis and properties of N6-substituted 2-amino-purine derivatives.
1. The synthesis, ultraviolet absorption spectra, and behaviour in alkali of N6-methoxy-, N6-methyl, hydroxy-, and N6-hydroxy-2-aminopurines have been described 2. N6-Methoxy-2-aminopurine riboside 5'-pyrophosphate has been prepared and used for polymerization with polynucleotide phosphorylase. 3. The copolymer containing N6-methoxy-2-aminopurine riboside and adenosine residues has been obtained; attempts to synthesize the homopolymer have not been successful. 4. All the purine analogues synthesized have been tested and shown to act mutagenically on Salmonella typhimurium TA1530.
D006863:Hydrogen-Ion Concentration; D009153:Mutagens; D011117:Polyribonucleotide Nucleotidyltransferase / Q000378:metabolism; D011685:Purine Nucleotides / Q000378:metabolism; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D009153:Mutagens; D011685:Purine Nucleotides; D011687:Purines; D011117:Polyribonucleotide Nucleotidyltransferase