Aurinetricarboxylic acid: a potent inhibitor of glucose-6-phosphate dehydrogenase.
Inhibition by aurinetricarboxylic acid (ATA) of glucose-6-phosphate (G6P) dehydrogenase was "competitive" with respect to G6P and "mixed type" with respect to NADP+. Inhibited enzyme bound two molecules of ATA. Kinetic constants, Km, Ki at varying pH suggested possible binding of the inhibitor by the sulfhydryl of the enzyme; of the several enzymes tested only milk xanthine oxidase and G6P dehydrogenase from bovine adrenal was inhibited by ATA.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D001312:Aurintricarboxylic Acid / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D002729:Chloromercuribenzoates / Q000494:pharmacology; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003545:Cysteine / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D002729:Chloromercuribenzoates; D003509:Cyclohexanecarboxylic Acids; D001312:Aurintricarboxylic Acid; D005954:Glucosephosphate Dehydrogenase; D014969:Xanthine Oxidase; D000469:Alkaline Phosphatase; D003545:Cysteine