[Effect of dipyroxime on the concentration of nicotinamide coenzymes and adenylate nucleotides in the myocardium and liver of rats poisoned with phthalophos].
Experiments were conducted on rats; in depression of blood cholinesterase activity by 68.6 percent phthalafos proved to decrease the myocardial nicotinamide coenzymes content on account of reduction in the amount of the oxidized forms. In the liver phthalafos diminished the content of oxidized and reduced forms of nicotinamide coenzymes, decreased the level of adenylic nucleotides chiefly at the expense of ATP. Diproxim prevented the changes caused by phthalafos in blood cholinesterase reactivation to 47.5 percent. It is supposed that the capacity of diproxim to normalize the oxidative processes in the cell by acting upon the nicotinamide coenzymes and adenylic nucleotides underlies its antidote action.
D000818:Animals; D002802:Cholinesterases / Q000097:blood; D007306:Insecticides / Q000506:poisoning*; D008099:Liver / Q000032:analysis*; D008297:Male; D009206:Myocardium / Q000032:analysis*; D009243:NAD / Q000032:analysis*; D009249:NADP / Q000032:analysis*; D010091:Oximes / Q000627:therapeutic use*; D010706:Phosmet / Q000506:poisoning*; D051381:Rats; D014289:Trimedoxime / Q000627:therapeutic use*
D007306:Insecticides; D010091:Oximes; D009243:NAD; D009249:NADP; D014289:Trimedoxime; D002802:Cholinesterases; D010706:Phosmet
Vliianie dipiroksima na soderzhanie nikotinamidnykh kofermentov i adenilovykh nukleotidov v miokarde i pecheni krys, otravlennykh ftalofosom.