[Detection of excessive chronic alcoholic consumption and control of withdrawal. Comparative study of respective values of the mean red-cell volume and serum gamma-glutamyl-transferase activity].
The routine detection of chronic alcoholism is necessary during any medical examination whether private or in hospital, or in occupational medicine. The practitionner now has available a simple reliable and cheap test. It consists of the serum estimation of gamma-glutamyl-transferase (gammaGT) and interpretation of the average red cell volume supplied by automatic counting of the red cell. Out of 120 chronic alcoholic subjects ; 67% has a gammaGT increased and 44% had macrocytosis. Under the influence of weaning, there was a rapid fall in gammaGT and a slower reduction in average red cell volume. gammaGT estimation was thus a more sensitive test than M.C.V. for the detection of chronic alcoholics and the control of withdrawal. Its association with the rise in immunoglobulin A-transferrin ratio which we have suggested permits the detection of almost all chronic alcoholics in the population studied.
D000217:Acyltransferases / Q000378:metabolism*; D000428:Alcohol Drinking; D000437:Alcoholism / Q000175:diagnosis*; D001810:Blood Volume; D002908:Chronic Disease; D004912:Erythrocytes; D006801:Humans; D008403:Mass Screening; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D005722:gamma-Glutamylcyclotransferase / Q000378:metabolism*
D000217:Acyltransferases; D005722:gamma-Glutamylcyclotransferase
Le dépistage de la consommation alcoolique chronique excessive et le contrôle du sevrage. Etude comparative des valeurs respectives du volume globulaire moyen (VGM) et de l'activité sérique de la gamma-glutamyl-transférase (gamma-GT).