In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA.
PR-D-92-EA was tested on isolated guinea pig ileum and rat stomach strips for activity against mediators probably released after allergen antibody union. It antagonized the response produced by histamine, bradykinin, serotonin, prostaglandin E2, prostaglandin F2ALPHA and slow-reacting substance of anaphylaxis (SRS-A). The concentrations which blocked 50% of the response were 150, 145, 92, 70, 47, and 32 mug/ml, respectively. This compound may be useful in the treatment of allergic conditions.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D001920:Bradykinin / Q000037:antagonists & inhibitors; D002264:Carboxylic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D000882:Haplorhini; D006634:Histamine H1 Antagonists; D007082:Ileum / Q000276:immunology; D066298:In Vitro Techniques; D008168:Lung / Q000276:immunology; D009119:Muscle Contraction / Q000187:drug effects; D011458:Prostaglandins E / Q000037:antagonists & inhibitors; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists; D013270:Stomach / Q000276:immunology
D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D002264:Carboxylic Acids; D006634:Histamine H1 Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D013189:SRS-A; D012702:Serotonin Antagonists; D001920:Bradykinin