Effects of cimetidine on adenylate cyclase activity of guinea pig gastric mucosa stimulated by histamine, sodium fluoride and 5'-guanylylimidodiphosphate.
Cimetidine, a recently developed histamine H2-receptor blocking agent has been shown to be a potent inhibitor of histamine-stimulated gastric acid secretion in rat, cat, dog and man. To study the mode of action of cimetidine the modification of stimulatory effects of histamine, sodium flouride and 5'-guanylylimidodiphosphate by cimetidine on the adenylate cyclase activity of guinea pig gastric mucosa was studied. The effect of cimetidine was also compared to that of metiamide, an older histamine H2-receptor antagonist. The effect of cimetidine was qualitatively similar to that of metiamide, i.e. a selective blockade of histamine H2-receptors. Quantitatively cimetidine was about 10-fold more potent than metiamide.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002642:Chick Embryo; D004347:Drug Interactions; D005459:Fluorides / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000201:enzymology*; D006146:Guanidines / Q000494:pharmacology*; D006150:Guanine Nucleotides / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008785:Metiamide / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology*
D006146:Guanidines; D006150:Guanine Nucleotides; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D008785:Metiamide; D006632:Histamine; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D005459:Fluorides