Residual effects of flunitrazepam.
1 Twelve normal subjects were tested on a large battery of tests after a hypnotic dose of flunitrazepam(1 or 2 mg) and a placebo. Psychological tests were given 12 h after the drug and physiological tests 12, 15 and 18 h after the drug. 2 The tests included self-ratings of hypnotic effects and mood, the electroencephalogram, the auditory electroencephalographic evoked response, skin conductance, tapping, card-sorting and the symbol copying test. 3 Both doses of flunitrazepam were effective hypnotics according to the ratings, with an anxiolytic effect the following day. The EEG was significantly altered up to 18 h after the drug and the behavioural tests showed a motor impairment 12 h after drug administration. 4 Nearly all changes displayed linear dose-related trends.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005445:Flunitrazepam / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D010919:Placebos; D011581:Psychological Tests; D013647:Task Performance and Analysis
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010919:Placebos; D005445:Flunitrazepam