[Biochemical studies on camomile components/III. In vitro studies about the antipeptic activity of (--)-alpha-bisabolol (author's transl)].
(--)-alpha-Bisabolol has a primary antipeptic action depending on dosage, which is not caused by an alteration of the pH-value. The proteolytic activity of pepsin is reduced by 50 percent through addition of bisabolol in the ratio of 1/0.5. The antipeptic action of bisabolol only occurs in case of direct contact. In case of a previous contact with the substrate, the inhibiting effect is lost.
D004305:Dose-Response Relationship, Drug; D006454:Hemoglobins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008722:Methods; D010434:Pepsin A / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D014238:Trichloroacetic Acid; D014443:Tyrosine / Q000378:metabolism
D006454:Hemoglobins; D012717:Sesquiterpenes; D014443:Tyrosine; D014238:Trichloroacetic Acid; D010434:Pepsin A
Biochemische Untersuchungen von Kamilleninhaltsstoffen. III. In-vitro-Versuche über die antipeptische Wirkung des (-)-alpha-Bisabolols