The effect of drugs on fetal heart rate variability.
Baseline FHR variability has been quantitated into the mathematical indices of differential index (short-term variability) and interval index (long-term variability). Normal values have been determined. The effect that drugs used during labor have on FHR baseline variability has been evaluated. A clinically meaningful change in variability has been observed following low-dose administration of Demerol, morphine, Nisentil, Phenergan, and Vistaril. A statistically significant increase in variability has been observed following administration of magnesium sulfate.
D000701:Analgesics, Opioid / Q000494:pharmacology; D005260:Female; D005318:Fetal Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006919:Hydroxyzine / Q000494:pharmacology; D007743:Labor, Obstetric; D008278:Magnesium Sulfate / Q000494:pharmacology; D011247:Pregnancy; D011398:Promethazine / Q000494:pharmacology
D000701:Analgesics, Opioid; D006919:Hydroxyzine; D008278:Magnesium Sulfate; D011398:Promethazine