Pharmacokinetics of intravenously injected chloramphenicol in baby pigs.
A sensitive fluorometric assay procedure for chloramphenicol and its metabolites was used to measure distribution in tissues and elimination of the drug after injection of 22 mg/kg iv in baby pigs. Disappearance of chloramphenicol from plasma was biphasic; an initial component was rapid (half-life about 9 min) and a second component had a half-life of 55 min. The total chloramphenicol levels in tissues and body fluids had half-life periods of 1-1.5 hr and dropped below limits of detectability within 9 hr after injection. About 80% of the injected dose was recovered from urine collected over the first 6 hr, and none thereafter. Fecal elimination, if occurring, was negligible.
D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D013552:Swine
D002701:Chloramphenicol