Evidence that 'inactive' renin is produced outside the kidney of the rat.
1. Inactive renin, which can be converted into an active form by acidification to pH 3-3, represents 4-63% of the total renin in rat peripheral plasma. 2. No inactive component could be found in the blood-free venous effluent of the perfused rat kidney before and after stimulation with isoprenaline. 3. This suggests a possible extrarenal source for inactive renin and may explain the presence of this component in anephric patients.
D000818:Animals; D004789:Enzyme Activation; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D012083:Renin / Q000097:blood / Q000378:metabolism*
D012083:Renin