Activation of the renal cortical and hepatic guanylate cyclase-guanosine 3' ,5'-monophosphate systems by nitrosoureas. Divalent cation requirements and relationship to thiol reactivity.
D000818:Animals; D002413:Cations, Divalent / Q000494:pharmacology; D006152:Cyclic GMP / Q000378:metabolism*; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000378:metabolism*; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000378:metabolism
D002413:Cations, Divalent; D009607:Nitrosourea Compounds; D013438:Sulfhydryl Compounds; D006162:Guanylate Cyclase; D006152:Cyclic GMP