[Study of the antispastic activity of prifinium bromide in motor dysfunction of the esophagus].
Motor disturbances of the oesophagus are attributable to hypermotility or hypomotility, or to peristaltic uncoordination of the upper or lower sphincter, or of the corpus. Endoesophageal manometry has enabled considerable progress to be made in the study of oesophageal dysfunction by allowing the spasm to be quantified. Treatment is poorly effective and its results are uncertain, save in the very few cases where surgery leads to resolution. For this reason, the efficacy of a new drug with marked antispastic properties, prifinium bromide, was investigated in 12 cases of megaoesophagus, of hiatal hernia, 6 of diverticulum, and 4 of dyskinesia in the light of the manometric values observed before and after its administration. The drug relieved spasm of the sphincters and corpus.
D003680:Deglutition Disorders / Q000188:drug therapy*; D004936:Diverticulum, Esophageal / Q000188:drug therapy; D004935:Esophageal Diseases / Q000188:drug therapy*; D004943:Esophagogastric Junction / Q000503:physiopathology; D006551:Hernia, Hiatal / Q000188:drug therapy; D006801:Humans; D009069:Movement Disorders / Q000188:drug therapy; D011759:Pyrrolidines / Q000627:therapeutic use*; D013035:Spasm / Q000188:drug therapy
D011759:Pyrrolidines
Studio dell'attività antispastica del prifinio bromuro nelle disfunzioni motorie dell'esofago.