[Neuroplegia and extracorporeal circulation. Comparison between combinations of droperidol-phenoperidine and chlorprothixene-dextromoramide in cardiac surgery].
After a quick review of the physiopathology of extra-corporeal circulation, the value of the use of neuroplegic drugs in cardiac surgery is recalled by means of pharmacological arguments. The experimental differences existing between the combinations droperidol - phenoperidine and chlorportixene - dextromoramide, on the rate of flow and on the pressure of the perfusion, and on the esophago-rectal thermic gradients during E.C.C. is then demonstrated. Statistic calculation confirmed the superiority of chlorprotixene in the realm of tissue perfusion during E.C.C. under hypothermia.
D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002749:Chlorprothixene / Q000009:adverse effects / Q000494:pharmacology*; D003916:Dextromoramide / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010638:Phenoperidine / Q000494:pharmacology*
D003916:Dextromoramide; D002749:Chlorprothixene; D010638:Phenoperidine; D004329:Droperidol
Neuroplégie et circulation extra-corporelle. Comparaison des associations dropéridol-phénopéridine et chlorprotixène-dextromoramide en chirurgie cardiaque