Lophyrotomin, a new toxic octapeptide from the larvae of sawfly, Lophyrotoma interrupta.
Lophyrotomin, a new toxic octapeptide, has been isolated from sawfly (Lophyrotoma interrupta) larvae using solvent extraction, dialysis, adsorption on polyamide, ion exchange chromatography on DEAE cellulose and silica gel G chromatography. On the basis of evidence from chemical methods, pmr and mass spectrometry, a partial structure is proposed. Lophyrotomin has an approximate intraperitoneal LD50 of 2 mg/kg for mice.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D004175:Diptera / Q000196:embryology*; D006863:Hydrogen-Ion Concentration; D007814:Larva / Q000032:analysis; D007928:Lethal Dose 50; D009842:Oligopeptides / Q000302:isolation & purification / Q000633:toxicity*; D012995:Solubility; D013045:Species Specificity; D014118:Toxins, Biological / Q000302:isolation & purification*
D000596:Amino Acids; D009842:Oligopeptides; D014118:Toxins, Biological