Inhibition of acute anaphylaxis in the chicken by anti-allergic drugs.
The anti-anaphylactic effects of four potential anti-allergic agents (DSCG: disodium cromoglycate, PRD-92-EA, M&B 22,948 and DECC: diethylcarbamazine citrate) were studied on cardiovascular responses of acute systemic anaphylaxis and chemical mediators of immediate hypersensitivity in chickens. Compounds M&B 22,948, PRD-92-EA, DSCG and DECC all inhibited cardiovascular manifestations of systemic anaphylaxis in domestic fowl. High doses of Compounds PRD-92 EA, M&B 22,948 and DECC also exhibited a nonspecific receptor blocking activity towards exogenously administered chemical mediators of anaphylaxis.
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001372:Aza Compounds / Q000627:therapeutic use; D001578:Benzopyrans / Q000627:therapeutic use; D002645:Chickens; D004205:Cromolyn Sodium / Q000627:therapeutic use; D004049:Diethylcarbamazine / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D011688:Purinones / Q000627:therapeutic use; D012710:Serum Albumin, Bovine / Q000276:immunology
D001372:Aza Compounds; D001578:Benzopyrans; D006634:Histamine H1 Antagonists; D011688:Purinones; D012710:Serum Albumin, Bovine; D004205:Cromolyn Sodium; D004049:Diethylcarbamazine