Enhancement of interferon induction in mice by polycationic modified polypeptides.
Combined intraperitoneal treatment of mice with poly I: C and a polycationic modified polypeptide (poly-DMAE-glutamine) was investigated. It was established that the presence of appropriate amounts of poly-DMAE-glutamine produced markedly enhanced serum interferon levels as compared to those produced by poly I: C alone. Similar combinations injected into mice produced full protection against lethal doses of mouse-virulent Semliki forest virus.
D000818:Animals; D001102:Arbovirus Infections / Q000517:prevention & control; D005973:Glutamine; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000627:therapeutic use; D007372:Interferons / Q000097:blood*; D051379:Mice; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D011070:Poly I-C / Q000494:pharmacology* / Q000627:therapeutic use; D012672:Semliki forest virus
D007369:Interferon Inducers; D010455:Peptides; D005973:Glutamine; D007372:Interferons; D011070:Poly I-C