Multiple factor analysis of the action of local anesthetics.
The pH jump data of Bianchi and Strobel [(1968) Trans. N.Y. Acad. Sci. Ser. II, 30, 1082-1092] on desheathed frog sciatic nerve are fitted to rate equations. A general quantitation of synergism, summation, and antagonism of anesthetics and of excitation is given.
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007526:Isoelectric Point; D008012:Lidocaine / Q000494:pharmacology; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects*; D011343:Procaine / Q000494:pharmacology; D011955:Receptors, Drug; D012584:Sciatic Nerve / Q000187:drug effects
D000779:Anesthetics, Local; D011955:Receptors, Drug; D011343:Procaine; D008012:Lidocaine