[Calcium containing antacids and acid rebound. Testing with intragastric titration and extragastric measurement of pH].
Intragastric titration with the pH being measured extragastrically is a method both precise and highly qualified for clinical trials of antacids and quantitative analysis of gastric secretion. In 12 patients with duodenal ulcer, acid secretion was measured by intragastric titration both before and after adminstration of a Ca-Mg-containing antacid. Acid secretion was found to be significantly lower after administration of the Ca-Mg-containing antacid, a so-called acid rebound could not be demonstrated.
D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use*; D005260:Female; D005750:Gastric Juice / Q000032:analysis; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy
D000863:Antacids; D002118:Calcium
Kalzium-haltiges Antazidum und Acid-Rebound.