Hemodynamic effects of aerosol propellants. II. Pulmonary circulation in the dog.
The inhalation of trichlorofluoromethane (FC11), dichlorotetrafluoroethane (FC114) and dichlorodifluoromethane (FC12) caused a reduction in mean aortic blood pressure but only FC11 and FC114 caused a reduction in mean pulmonary arterial pressure. The primary cause of the fall is a decrease in pulmonary blood flow. When blood flow to a lobe is kept constant and the adrenergic alpha receptors are blocked by injection of phentolamine, the inhalation of FC11 caused vasodilation. In the intact circulation, the vasodilation is masked by release of catecholamines which constrict the pulmonary blood vessels.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000335:Aerosol Propellants / Q000494:pharmacology*; D000336:Aerosols / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000335:Aerosol Propellants; D000336:Aerosols; D006845:Hydrocarbons, Fluorinated; D010276:Parasympatholytics