5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanimines, potential antipsychotic agents.
The title compounds (most notably 2a) were synthesized on the basis of the N-methylation hypothesis of schizophrenia. They were evaluated in dopamine and haloperidol receptor assays. The binding characteristics were comparable in some cases to known neuroleptics.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D001362:Avoidance Learning / Q000187:drug effects; D001667:Binding, Competitive; D002417:Cattle; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000633:toxicity; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists; D006220:Haloperidol / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D013876:Thiophenes; D006220:Haloperidol; D003913:Dextroamphetamine; D004298:Dopamine