N-Hydroxylation of pentobarbital in man.
After oral administration of 14C-labeled pentobarbital to healthy subjects, most ot the radioactivity was recovered in urine over a period of 6 days. Only a minute amount (approximately 1%) of unchanged pentobarbital was found in the urine. Four major metabolites were found and isolated. One was 3'-hydroxypentobarbital, which has been previously identified by Maynert. The second could be identified as N-hydroxypentobarbital on the basis of its spectral and chemical properties. The other two metabolites were not identified.
D002855:Chromatography, Thin Layer; D006801:Humans; D006900:Hydroxylation; D008297:Male; D013058:Mass Spectrometry; D010424:Pentobarbital / Q000378:metabolism* / Q000652:urine; D013237:Stereoisomerism
D010424:Pentobarbital