The effects of adrenergic agonists and blockers on antigen-induced DNA synthesis in vitro.
The effects of both alpha and beta adrenergic agonists and blockers on antigen-stimulated DNA synthesis in human lymphocyte cultures were studied. Results show that antigen-induced responses were enhanced by the presence of the beta blockers, propranolol and dichloroisoproterenol, and that this effect appeared to be specific blocking of the lymphocyte beta receptor since D (+) propranolol, a compound devoid of such acitvity, has no effect. Similarly, and alpha adrenergic agonist such as norepinephrine enhanced lymphocyte responsiveness.
D000322:Adrenergic Agonists / Q000494:pharmacology*; D000941:Antigens; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D007109:Immunity / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013237:Stereoisomerism; D013565:Sympatholytics / Q000494:pharmacology*
D000322:Adrenergic Agonists; D000941:Antigens; D013565:Sympatholytics; D004247:DNA; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D010646:Phentolamine