Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains.
An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo[a]pyrene hydroxylation, the data indicate that in mice, the metabolism of these two substrates is under similar regulatory control.
D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D003640:Dealkylation; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D010615:Phenacetin / Q000378:metabolism*; D013997:Time Factors
D008748:Methylcholanthrene; D001579:Benzopyrene Hydroxylase; D010615:Phenacetin