Search for correlates of resistance to virulent challenge in mice immunized with Coxiella burnetii.
Mice immunized with live phase I or phase II Coxiella burnetii, with killed phase I or phase II organisms or with trichloroacetic acid (TCAE) or phenol (PE) extracts were resistant to intraperitoneal infection with phase I C. burnetii irrespective of whether or not they displayed phase I antibody response at the time of virulent challenge. Increased phagocytosis of purified phase I organisms by blood leukocytes or peritoneal exudate cells (PEC) was noticed only in mice with phase I agglutinating antibodies in their sera or peritoneal washings. Passive transfer of resistance was made possible only by sera containing phase I agglutinating antibodies. Adoptive transfer of immunity by spleen cells, but not by PEC, was achieved providing that these cells were taken from mice immunized with live phase I C. burnetii.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001202:Ascitic Fluid / Q000166:cytology; D001428:Bacterial Vaccines; D003381:Coxiella / Q000276:immunology* / Q000472:pathogenicity; D007109:Immunity; D007111:Immunity, Cellular; D007114:Immunization; D007116:Immunization, Passive; D007962:Leukocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010587:Phagocytosis; D011778:Q Fever / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D014613:Vaccines, Attenuated; D014774:Virulence
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated