Comparative antisecretory activity of several drugs in the gastric fistula squirrel monkey and rat.
A series of known antisecretory compounds, including glycopyrrolate, clonidine, propantheline bromide, CMN 131 (2-pyridylthiocetamide), and desmethylimipramine (DMI) were tested in the gastric fistula rat and monkey. The order of potency for inhibiting acid output was similar in both species. A general similarity exists in the responsiveness of the rat and monkey to gastric antisecretory agents. These data support the use of the squirrel monkey for assessment of gastric antisecretory activity.
D000818:Animals; D002404:Catheterization; D003864:Depression, Chemical; D005750:Gastric Juice / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D000882:Haplorhini; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D012453:Saimiri; D013045:Species Specificity; D013270:Stomach / Q000502:physiology