The central and peripheral effectiveness of two oxotremorine-antagonists determined using oxotremorine-induced tremor and salivation.
Two oxotremorine antagonists have been examined using oxotremorine as the tremor salivation inducer and the ratios between the central and peripheral nervous systems determined. Under these conditions these compounds are still more effective antagonists centrally than peripherally. Differences in distribution to the various muscarinic receptors involved is believed to be the major factor in determining this separation of central and peripheral activities.
D000480:Alkynes / Q000494:pharmacology; D000818:Animals; D001115:Arecoline / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D010095:Oxotremorine / Q000037:antagonists & inhibitors*; D011760:Pyrrolidinones / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects*; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced / Q000503:physiopathology*
D000480:Alkynes; D011760:Pyrrolidinones; D001115:Arecoline; D010095:Oxotremorine