[Effect of a new central adrenolytic on cardiac metabolic indices in neurogenic damage].
It is shown that in rabbits subjected to an electric stimulation of the aortic arch there developed concurrently with depletion of tissular norepinephrine reserves in the myocardium also gross metabolic disorders. A preliminary introduction of the drug izm-611 by blocking central alpha-adrenoreseptors at the same time prevented depletion of the tissular norepinephrine reserves and development of disturbances of the energy exchange in the myocardium caused by its neurogenic damage.
D000317:Adrenergic alpha-Antagonists; D000818:Animals; D004558:Electric Stimulation; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006335:Heart Injuries / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010627:Phenethylamines / Q000494:pharmacology*; D010648:Phenylacetates / Q000494:pharmacology; D011817:Rabbits; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D010627:Phenethylamines; D010648:Phenylacetates; D013565:Sympatholytics
Vliianie novogo tsentral'nogo adrenolitika na nekotorye pokazateli metabolizma serdtsa pri ego neirogennom povrezhdenii.