Genital organs. Auto and homotransplantation in forty dogs.
Auto and homo transplantation of the uterus and ovaries was studied in 40 bitches divided into four groups. Group A served as a control. In group B the omentopexy technique of auto-transplantation was used. This method did not prove very rewarding and all 12 grafts were found to have degenerated and were non-functioning when relaparotomy was performed, 3 months after transplantation. In group C, auto transplantation with vascular anastomosis was performed in 12 dogs, yielding satisfactory results including one successful pregnancy and the delivery of 3 healthy puppies. In group D homotransplantation of the internal genital organs was performed in two sets of twin dogs. No immunosuppressive treatment was used. These grafts survived for a limited period as proved by the functional tests and X-ray examination but after 3 months were found to be necrotic and degenerated. Graft function and viability was established by: X-ray examination, cytology of vaginal smears, the effect of gonadotropins on the grafted ovaries and finally relaparotomy undertaken after 3 weeks and 3 months.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007047:Hysterosalpingography; D007083:Iliac Artery / Q000601:surgery; D007084:Iliac Vein / Q000601:surgery; D010053:Ovary / Q000187:drug effects / Q000637:transplantation*; D011247:Pregnancy; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014599:Uterus / Q000098:blood supply / Q000637:transplantation*; D014621:Vagina / Q000098:blood supply; D014626:Vaginal Smears
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine