[Inhibiting action of glycomacropeptide on stomach secretion induced by various humoral stimulants].
Tests staged on dogs demonstrated the action of GMP to differ depending upon the nature of the gastric secretion stimulant actually used. The inhibition of the gastric juice secretion occurring against the background of multiple introduction of histamine or gastrin tetrapeptide amide was quite spectacular: the secretion dropped down to zero and the action was more prolonged than following administration of pentagastrin with which the secretion was not inhibited to such a sharp degree and the effect of GMP was less protracted. The mechanism of the GMP action of the gastric secretion and the causes of described differences require further investigations.
D000818:Animals; D004285:Dogs; D005749:Gastric Inhibitory Polypeptide / Q000494:pharmacology*; D005750:Gastric Juice / Q000032:analysis / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000037:antagonists & inhibitors; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors*; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D010446:Peptide Fragments / Q000037:antagonists & inhibitors; D010447:Peptide Hydrolases / Q000032:analysis; D013997:Time Factors
D005755:Gastrins; D005768:Gastrointestinal Hormones; D006633:Histamine Antagonists; D018377:Neurotransmitter Agents; D010446:Peptide Fragments; D005749:Gastric Inhibitory Polypeptide; D010447:Peptide Hydrolases; D010418:Pentagastrin
Ingibiruiushchee deĭstvie glikomakropeptida na sekretsiiu zheludka, vyzvannuiu razlichnymi gumoral'nymi razdrazhiteliami.