Arterial hypoxemia caused by intravenous ketamine.
Ketamine given IV in a dose of 2 mg/kg caused a significant reduction in Pao2 in 7 patients spontaneously breathing with an unassisted airway. Under the same conditions, in 7 patients, ketamine (2 mg/kg IV) preceded by diazepam (0.2 mg/kg IV) also caused a reduction in Pao2 not significantly different from that caused by ketamine. In some patients, alarmingly low levels of Pao2 ( less than or equal to 40 torr) were seen following ketamine administration. Based on these findings, the authors recommend that O2 and ventilatory assistance accompany ketamine given IV for anesthesia.
D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D001158:Arteries; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000139:chemically induced*; D007649:Ketamine / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects
D002245:Carbon Dioxide; D007649:Ketamine; D003975:Diazepam; D010100:Oxygen