Inhibition of gastric secretion in treatment of pancreatic insufficiency.
The content of pancreatic enzymes in the duodenum was studied in two patients with pancreatic achylia after a standard meal supplemented with commercial pancreatic extract. Gastric transit of the enzymes, with appearance of near-normal amounts in the duodenal contents, occurred only after inhibition of gastric secretion and buffering of residual gastric acid with antacids. Gastric inhibition and neutralisation of acid are therefore necessary for the satisfactory treatment of patients with pancreatic exocrine insufficiency but normal gastric function.
D002908:Chronic Disease; D004386:Duodenum / Q000201:enzymology; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008785:Metiamide / Q000627:therapeutic use*; D010182:Pancreatic Diseases / Q000628:therapy*; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D010189:Pancreatic Juice / Q000378:metabolism; D010195:Pancreatitis / Q000628:therapy; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors
D010184:Pancreatic Extracts; D008785:Metiamide; D013890:Thiourea