Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntingdon's chorea.
Kainic acid lesion of cell bodies in the dorsal striatum enhanced the stereotypy-producing effects of d-amphetamine without affecting the sterotypy produced by the direct receptor agonist apomorphine. This pattern of results parallels that found in patients suffering from Hungtington's chorea, thus strengthening the parallels between the kainic acid animal model and the human disease state initially suggested on biochemical gounds. The present results further suggest a dissociation of the mechanisms involved in the production of stereotypy by these two drugs, perhaps in terms of differential involvement of the striato-nigral negative feedback loop.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D003913:Dextroamphetamine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009714:Nucleus Accumbens / Q000201:enzymology; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D011759:Pyrrolidines; D014446:Tyrosine 3-Monooxygenase; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D001058:Apomorphine; D007608:Kainic Acid; D003913:Dextroamphetamine