Arterial hydrogen ion versus CO2 on depth and rate of breathing in decerebrate cats.
Arterial blood hydrogen ion concentration (Ha+) was altered over the range of 25 to 110 nM (pH 7.60 to 6.96) by slow intravenous infusion of 1.0 N NaHCO3 or 0.5 N HC1 at controlled levels of Paco2in unanesthetized decerebrate cats. Respiratory f varied as a single function of Vt irrespective of a lterations in Paco2 and Ha+ even after interruption of the carotid sinus nerves. The dependence of f upon Vt was abolished by vagotomy. However, Vt continued to respond to changes in Ha+ over its entire range after combined section of the vagus and carotid sinus nerves. In all statxceeded by 5 to 10 times the delta Vt/delta Ha+ response to acid or bicarbonate infused under isocapnic control. Increases and decreases of ha+ caused downward and upward shifts, respectively, in the operating setpoint of the CO2 regulation system.
D000142:Acidosis, Respiratory / Q000097:blood; D000472:Alkalosis, Respiratory / Q000097:blood; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002346:Carotid Sinus / Q000503:physiopathology; D002415:Cats; D003655:Decerebrate State / Q000097:blood*; D003714:Denervation; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000503:physiopathology; D010993:Plethysmography, Whole Body; D011434:Proprioception; D012119:Respiration; D013990:Tidal Volume; D014628:Vagotomy; D014630:Vagus Nerve / Q000503:physiopathology
D002245:Carbon Dioxide