Antigen-specific nonimmunoglobulin factor that neutralizes xenotropic virus is associated with mouse serum lipoproteins.
A soluble nonimmunoglobulin factor that specifically neutralizes mouse xenotropic C-type virus is found in normal mouse sera. It is stable from pH 2 to neutrality and resists ether extraction, freezing, or brief heating to 100 degrees. It can be separated from immunoglobulins by ultracentrifugation at a density of 1.21 g/cm3. Neutralizing activity is only found with the serum lipoproteins in the fraction with density less than 1.21 g/cm3.
D000818:Animals; D000956:Antigens, Viral; D000998:Antiviral Agents; D001798:Blood Proteins / Q000302:isolation & purification*; D002499:Centrifugation, Density Gradient; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D009052:Leukemia Virus, Murine / Q000254:growth & development* / Q000276:immunology; D008074:Lipoproteins / Q000302:isolation & purification; D051379:Mice / Q000097:blood*; D012190:Retroviridae / Q000254:growth & development* / Q000276:immunology; D012995:Solubility; D014461:Ultracentrifugation
D000956:Antigens, Viral; D000998:Antiviral Agents; D001798:Blood Proteins; D008074:Lipoproteins