Nasal absorption of insulin in dogs.
The intranasal application of an insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemia. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.
D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D013501:Surface-Active Agents / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D013501:Surface-Active Agents