Histamine H2-receptor antagonists and gastric acid secretion -- a progress report.
Histamine H2-receptor antagonists, including burimamide, metiamide and cimetidine, are effective antagonists of histamine-stimulated acid secretion from mammalian, avian or reptilian gastric mucosa. Acid secretion stimulated by gastrin or pentagastrin is also inhibited by these drugs, but there is disagreement about the effects of these drugs on acid secretion resulting from activation of acetylcholine receptors. Based on the pharmacological evidence possibilities of treatment by these drugs were discussed in cases with excessive stimulation of acid secretion due to high blood levels of histamine or gastrin. The positive results in several trials on Zollinger-Ellison syndrome and peptic ulcer were very impressive. Some practical problems have still to be solved, for example the appropriate phase for applying the drugs. The demonstrated clinical effectiveness, however, against peptic ulceration offers a clear alternative to surgery for many patients.
D002049:Burimamide / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000037:antagonists & inhibitors; D006146:Guanidines / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008785:Metiamide / Q000494:pharmacology; D010276:Parasympatholytics; D010437:Peptic Ulcer / Q000188:drug therapy; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy
D005755:Gastrins; D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D010276:Parasympatholytics; D008785:Metiamide; D002049:Burimamide