1,8-naphthyridine derivatives: synthesis and pharmacological evaluation of beta-receptor blocking activity.
The synthesis of a number of 1-alkyl-7-(2-hydroxy-3-alkylaminopropoxy)-1,8-naphthyridin-2-ones is described. The compounds studied were prepared by reaction of 1-alkyl-7-hydroxy-1,8-naphthyridin-2-ones with epichlorohydrin. The substituted epoxy intermediates obtained were allowed to react with amines and gave the desired products. All the compunds prepared were devoid of beta-blocking activity.
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000925:Anticoagulants / Q000138:chemical synthesis; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D007202:Indicators and Reagents; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D007202:Indicators and Reagents; D009287:Naphthyridines