Memory formation: evidence for a specific neurochemical system in the amygdala.
beta-Adrenergic antagonists injected into the amygdala complex of rats trained in a passive avoidance task produced time-dependent and dose-dependent decreases in retention of the task. In addition, the effects observed with beta-adrenergic antagonists were both stereospecific and reversed by norepinephrine. The results support a role for an amygdala beta-adrenergic system in memory processes.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced*; D000648:Amnesia, Retrograde / Q000139:chemically induced*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051381:Rats; D013237:Stereoisomerism; D013997:Time Factors
D000319:Adrenergic beta-Antagonists