N-Acetylation of drugs. A genetically controlled reciprocal relationship between drug N-acetylating enzymes of rabbit liver and peripheral blood cells.
The reciprocal relation between liver isoniazid N-acetyltransferase and blood p-aminobenzoic and N-acetyltransferase previously reported is confirmed and found to be expressed in erythrocytes and lymphocytes of genetically rapid and slow isoniazid-acetylator rabbits. Both erythrocytes and lymphocytes from slow acetylator rabbits contained 2.5-3.3 times as much p-aminobenzoic acid N-acetyltransferase activity as the same cells from rapid acetylator rabbits. Mechanisms which might account for the reciprocal association between liver and blood N-acetyltransferases are considered.
D010129:4-Aminobenzoic Acid; D000123:Acetyltransferases / Q000097:blood / Q000378:metabolism*; D000375:Aging; D000818:Animals; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D066298:In Vitro Techniques; D007538:Isoniazid; D008099:Liver / Q000201:enzymology*; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D010641:Phenotype; D011817:Rabbits; D013418:Sulfamethazine; D013997:Time Factors
D013418:Sulfamethazine; D000123:Acetyltransferases; D010129:4-Aminobenzoic Acid; D007538:Isoniazid