Response to angiotensins I and II and to AI-converting-enzyme inhibitor in a shark.
The spiny dogfish shark, which does not have renal juxtaglomerular cells, exhibits a strong pressor response to both angiotensin I and II. A nonapeptide, angiotensin I-converting-enzyme inhibitor, blocks the pressor response to angiotensin I in this fish. The pressor response to both angiotensin II and norepinephrine is completely blocked by the adrenergic blocking drug phentolamine.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004284:Dogfish / Q000502:physiology*; D005260:Female; D005730:Ganglionic Blockers / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006584:Hexamethonium Compounds / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D012754:Sharks / Q000502:physiology*; D013722:Teprotide / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D009842:Oligopeptides; D000804:Angiotensin II; D013722:Teprotide; D010646:Phentolamine