Immunologically mediated drug-induced acute renal failure.
(1) AIN is the most frequent pattern of drug-induced immunologically mediated renal injury. A number of drugs may be responsible for AIN, namely methicillin and other penicillin derivatives, rifampicin, phenindione and sulfonamides. Particular clinical and pathological features often suggest an immune pathogenetic mechanism. IgG anti-TBM and IgE antibodies have been found in only a few cases and it is likely that antibody-mediated and cell-mediated injury may operate in the same patient. (2) Only few examples of drug-induced vasculitis and glomerulonephritis are known, and the pathophysiology of this kind of renal damage is poorly understood.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000941:Antigens; D001485:Basement Membrane / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology / Q000473:pathology; D005897:Glafenine / Q000009:adverse effects; D005921:Glomerulonephritis / Q000139:chemically induced; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology; D007684:Kidney Tubules / Q000276:immunology; D008712:Methicillin / Q000009:adverse effects / Q000276:immunology; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D010400:Penicillin G; D010406:Penicillins / Q000009:adverse effects* / Q000276:immunology; D010630:Phenindione / Q000009:adverse effects; D012293:Rifampin / Q000009:adverse effects / Q000276:immunology; D013449:Sulfonamides / Q000009:adverse effects; D014657:Vasculitis / Q000139:chemically induced / Q000473:pathology
D000941:Antigens; D010406:Penicillins; D013449:Sulfonamides; D005897:Glafenine; D010630:Phenindione; D010400:Penicillin G; D008712:Methicillin; D012293:Rifampin