[Tumour hyperacidulation through intravenous glucose infusion enhanced by amygdalin and beta-glucosidase application (author's transl)].
Tumour peracidity in otherwise moderately hyperacidulated tumours or tumour regions of DS carcinosarcoma-bearing Wistar rats attained by glucose infusion was substantially increased by simultaneous infusion of amygdalin and intratumoral i.m. or i.v. application of beta-glucosidase. Here the pH value of healthy tissue, measured at the sceletal muscle, remained unchanged. By means of the said process, tumour hyperacidulation has been raised to a level of deltapH =0.97; attaining a pH difference between tumourous and normal tissue of up to deltapH = 1.6. In one case, the slope of pH reduction in the tumour increased to 870%. Moreover, combined administration of glucose, amygdalin and beta-glucosidase evoked a significant cancerostatic effect hypogenesis, tumour regression) being comparable with the action of an Ifosfamid dosage of 150 mg-kg-1. However, i.m. and i.v. application of beta-glucosidase under narcosis results in an overall process that still remains somewhat too toxic. Hence optimizing studies are intended with the particular aim to further improve the comparability of this process.
D000143:Acids / Q000378:metabolism*; D000678:Amygdalin / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005959:Glucosidases / Q000008:administration & dosage / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009570:Nitriles / Q000494:pharmacology*; D051381:Rats
D000143:Acids; D009570:Nitriles; D000678:Amygdalin; D005959:Glucosidases
Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersäuerung in vivo durch Amygdalin und beta-Glukosidase