Evidence of a pure "contraction alkalosis= in awaken rat.
A pure contraction alkalosis with no urinary loss of bicarbonate was evidenced in awaken rat, after a Furosemide IV injection. We observed: 1) an early and important respiratory compensation possibly owing to a simultaneous contraction of CSF volume, thus increasing bicarbonate concentration. 2) a net shift of HCO3- towards intracellular compartment, in proportion to the magnitude of the contraction rather than to bicarbonate gradient across the membrane.
D000136:Acid-Base Equilibrium; D000471:Alkalosis / Q000139:chemically induced* / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000097:blood / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D051381:Rats
D001639:Bicarbonates; D005665:Furosemide