[Influence of antirheumatic phenylacetic acid derivatives on glycosaminoglycan metabolism of fibroblast culture (author's transl)].
Murine embryonic fibroblast monolayer cultures were used to study the influence of the antirheumatic phenylacetic acid derivatives ibufanac, ibuprofen, alclofenac and bufexamac and of phenylbutazone as a reference compound on glycosaminoglycan (GAG) metabolism viability and multiplication of cells cultured in vitro. The phenylacetic acid derivatives as well as phenylbutazone showed in concentrations between 10(-3) and 10(-5) M a significant inhibitory effect on GAG production and in concentrations between 10(-3) and 3.3 X 10(-4) M a cytostatic effect; bufexamac was cytostatically active up to the concentration of 10(-5) M. Ibufenac, ibuprofen and alclofenac exhibited a similar behaviour as other non-steroidal antirheumatic drugs regarding their influence of GAG metabolism and on cell multiplication.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002019:Bufexamac / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D007052:Ibuprofen / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology*; D010653:Phenylbutazone / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans; D010648:Phenylacetates; D002019:Bufexamac; D010653:Phenylbutazone; D007052:Ibuprofen
Untersuchungen über den Einfluss antirheumatisch aktiver Phenylessigsäurederivate auf den Glykosaminoglykanstoffwechsel von Fibroblastenkulturen