Experimental E. coli arthritis in the rabbit. A model of infectious and post-infectious inflammatory synovitis.
Rabbit knee joints challenged with E. coli 06 underwent a self-limited infection lasting several weeks followed by a prolonged post-infectious inflammatory arthritis. The E. coli used did not possess collagenolytic activity nor did a variety of common aerobic clinical isolates. Articular cartilage destruction occurred by two basically different mechanisms: u) direct invasion of pannus at the juxtaarticular margins, and 2) fibrillation in cartilage to cartilage contact areas. Weekly measurement of intra-articular pH and temperature were correlated with bacteriologic findings and groww and microscopic pathologic events.
D000818:Animals; D001170:Arthritis, Infectious / Q000382:microbiology* / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000201:enzymology; D004927:Escherichia coli Infections / Q000473:pathology; D005269:Femur / Q000473:pathology; D006614:Hindlimb; D006863:Hydrogen-Ion Concentration; D007719:Knee Joint / Q000473:pathology; D003012:Microbial Collagenase / Q000032:analysis; D011817:Rabbits; D013585:Synovitis / Q000382:microbiology* / Q000473:pathology
D003012:Microbial Collagenase