Conformation of hyaluronate in neutral and alkaline solutions.
Increasing the pH of a neutral salt solution of sodium hyaluronate to 12.5 produces a rapid drop in viscosity which is reversible upon restoring the pH to neutrality. Light scattering data showing a decrease in radius of gyration with no change in molecular weight and negative results with chondroitin and other acidic glycosaminoglycans suggest that the conformational change is specific for hyaluronate molecules.
D006820:Hyaluronic Acid; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008968:Molecular Conformation; D008970:Molecular Weight; D012995:Solubility; D014783:Viscosity
D006820:Hyaluronic Acid