Serum and urine phosphate during short-term beta-adrenergic blockade in healthy men.
Treatment of 6 healthy adult men with a beta-blocker, timolol, resulted in a rise in serum phosphate which was maintained for the 5 days of therapy. This rise was accompanied by a transient fall in urine phosphate and a rise in the tubular maximum for phosphate reabsorption per unit glomerular filtration rate (TmPO4/GFR). No change in circulating parathyroid hormone or growth hormone could be demonstrated.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D002118:Calcium / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013997:Time Factors; D013999:Timolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D010281:Parathyroid Hormone; D010710:Phosphates; D013999:Timolol; D003404:Creatinine; D002118:Calcium