Trial of an alpha-adrenolytic drug (indoramin) for nocturnal enuresis.
The investigation of methods of treatment known to be effective in controlling nocturnal enuresis may yield information on the pathophysiology of the condition. An attempt has been made to mimic the known alpha-adrenolytic action of imipramine by treating a group of 14 enuretic school-children with a competitive alpha-adrenoceptor blocking substance, indoramin. Treatment in the doses used had no significant effect on night-wetting frequency.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004775:Enuresis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007217:Indoramin / Q000627:therapeutic use*; D008297:Male
D000317:Adrenergic alpha-Antagonists; D000929:Antidepressive Agents, Tricyclic; D007211:Indoles; D007217:Indoramin