Selective reduction and proteolysis in the hinge region of liganded and unliganded antibodies: identical kinetics suggest lack of major conformational change in the hinge region.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D004591:Electrophoresis, Polyacrylamide Gel; D007128:Immunoglobulin Fragments / Q000032:analysis; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D008024:Ligands; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011487:Protein Conformation; D011817:Rabbits; D013296:Streptococcus pneumoniae
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D008024:Ligands; D011135:Polysaccharides, Bacterial