Experiments on the preparations and testing of associated vaccine against foot and mouth disease and vesicular disease in swine.
Tests for associated immunization of swine against Foot and Mouth Disease (FMD) and Vesicular Disease (SVD) of swine were carried out. As a result of this investigation, it was established that the prepared and tested inactivated oil vaccine is harmless and immunogenic in sensitive animals. In investigating the course of immunity, the presence of antibody against both antigens was demonstrated in vaccinated animals. All once-vaccinated animals were defended against the virus of SVD during challenge, and 75% of them were defended against FMD. After revaccination, all immunized swine were defended against infection with both viruses. The question of the quality of the associated vaccine and the possibilities of its massive use in industrial swine rearing was discussed.
D000276:Adjuvants, Immunologic; D000536:Aluminum Hydroxide; D000818:Animals; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D005557:Formaldehyde; D006863:Hydrogen-Ion Concentration; D007114:Immunization; D007117:Immunization, Secondary; D009500:Neutralization Tests; D013552:Swine; D014720:Vesicular Exanthema of Swine / Q000517:prevention & control*; D014765:Viral Vaccines / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D014765:Viral Vaccines; D005557:Formaldehyde; D000536:Aluminum Hydroxide