Ovum aging and pH imbalance as a cause of chromosomal anomalies in the hamster.
Using female hamsters mated in estrus, we have produced triploid embryos as manifestations of pregnancy wastage by combining delays of 3 to 4 hours in ferilization with exposure of the animals to hypoxia. Among the triploid embryos only XXX and XXY karotypes occurred, indicating derivation from XX-containing ova. These findings have relevance to human reproduction.
D000818:Animals; D002869:Chromosome Aberrations / Q000209:etiology*; D025063:Chromosome Disorders; D006224:Cricetinae; D005260:Female; D005306:Fertilization; D005313:Fetal Death / Q000209:etiology; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000150:complications; D008647:Mesocricetus; D010063:Ovum / Q000502:physiology*; D011123:Polyploidy; D011247:Pregnancy