The value of a histamine H2-receptor antagonist in the management of patients with the Zollinger-Ellison syndrome.
Inhibition of acid secretion by an H2-receptor antagonist (metiamide) was assessed in three patients with the Zollinger-Ellison syndrome. Metiamide (200 or 300 mg) inhibited acid secretion transiently (2 1/2 hours) by 85 to 100 per cent in all patients. Although anticholinergic drugs alone inhibited acid secretion by only 0 to 35 per cent in these patients, the combination of metiamide and anticholinergic markedly prolonged the inhibitory effect of metiamide. Total gastrectomy was refused by one patient, and was impossible in another; both were treated with metiamide and anticholinergic for five and 10 months. A third patient was treated with metiamide and anticholinergic for three weeks in preparation for total gastrectomy. Ulcer pain and diarrhea disappeared, and each gained weight. H2-receptor antagonists may be useful in the treatment of some patients with the Zollinger-Ellison syndrome.
D000328:Adult; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008785:Metiamide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011413:Propantheline / Q000008:administration & dosage / Q000627:therapeutic use; D011955:Receptors, Drug / Q000187:drug effects*; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy*
D006634:Histamine H1 Antagonists; D011955:Receptors, Drug; D011413:Propantheline; D008785:Metiamide; D013890:Thiourea; D006024:Glycopyrrolate