The elective treatment of graft-versus-host disease following a bone marrow graft from a father to a son with severe combined immunodeficiency.
The details of the first successful bone marrow graft from father to son are described. The recipient developed an acute graft-versus-host reaction on the seventh day which was successfully treated with anit-lymphocyte globulin and methotrexate. This regime did not destroy the graft and the child is alive and well with normal immunological function some 2 1/2 years later.
D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D005500:Follow-Up Studies; D006087:Graft vs Host Reaction; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007565:Jaundice; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011379:Prognosis; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D008727:Methotrexate