Enzymatic activity of blood lymphocytes experimental tsutsugamushi fever in mice.
The influence of tsutsugamushi fever infection on the metabolism of blood lymphocytes of mice differing in susceptibility to Rickettsia tsutsugamushi and of rifampicine and tetracycline treatment was studied. In susceptible mice, the activity of oxidation-reduction processes in lymphocytes increased at 7--10 days of the disease and became normal upon recovery of the animals. In mice with low susceptibility this increase of the activity began and terminated much earlier, at 3--5 days. Treatment of the infection with antibiotics resulted in a rapid arrest of the disease and normalization of the lymphocyte activity. The relationship between susceptibility of the animals to R. tsutsugamushi and the activity of oxidation-reduction enzymes is discussed on the example of succinate dehydrogenase.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D004195:Disease Models, Animal; D008214:Lymphocytes / Q000201:enzymology*; D051379:Mice; D012285:Orientia tsutsugamushi / Q000276:immunology; D012293:Rifampin / Q000627:therapeutic use; D012612:Scrub Typhus / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D013385:Succinate Dehydrogenase / Q000097:blood*; D013752:Tetracycline / Q000627:therapeutic use
D000907:Antibodies, Bacterial; D013385:Succinate Dehydrogenase; D013752:Tetracycline; D012293:Rifampin