4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol.
1. 4,4'-Dimethylcholesta-7,9,14-trienol is an intermediate in the metabolism of dihydroagnosterol to cholesterol by rat liver homogenate. 2. This triene is reduced by a rat liver microsomal preparation in the presence of NADPH to give 4,4'-dimethylcholesta-7,9-dienol under anaerobic conditions. 3. Reduction of the triene in the presence of [4-3H2]NADPH resulted in the incorporation of 3H into the product. 4. Under aerobic conditions the triene is converted into cholesterol by a rat liver homogenate.
D000818:Animals; D002782:Cholestenes / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis; D066298:In Vitro Techniques; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009249:NADP; D051381:Rats
D002782:Cholestenes; D007810:Lanosterol; C015140:dihydroagnosterol; D009249:NADP; D002784:Cholesterol