PH oscillations in cell suspensions of Dictyostelium discoideum: their relation to cyclic-amp signals.
Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to investigate the effect of externally added cAMP pulses on the oscillations. Both a temporary increase in amplitude and a permanent phase shift can be induced. The phase-response curve indicates that the period can be increased and decreased by rhythmic stimulation with cAMP pulses.
D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D004023:Dictyostelium / Q000187:drug effects / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009235:Myxomycetes / Q000378:metabolism*
D000242:Cyclic AMP