Observations in man of hypoglycaemia during selective and non-selective beta-blockade.
The acute hypoglycaemic reaction is accompanied by a rise in systolic and a slight fall in diastolic blood pressure and a tachycardia. In contrast, during beta-blockade with propranolol there is a rise of both systolic and diastolic blood pressures and bradycardia. Restoration of blood glucose to normal is delayed. With metoprolol there is a lesser increase in diastolic blood pressure and a slight tachycardia. Restoration of the blood glucose to normal is little delayed. When patients liable to hypoglycaemia require a beta-blocking agent, it is suggested that a selective blocker such as metoprolol should be used.
D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000378:metabolism; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage / Q000378:metabolism; D013610:Tachycardia / Q000139:chemically induced
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D011433:Propranolol; D008790:Metoprolol