Suprression of local graft-versus-host reactions by mouse fetal and newborn spleen cells.
Fetal splenic but not thymic lymphocytes significantly reduce the ability of parenteral adult spleen cells to elicit local graft-versus-host reactions in F1 recipients. This suppressive activity wanes early after birth. There is no requirement for histo compatibility between reacting and suppressor cells.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000961:Antilymphocyte Serum; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy; D051379:Mice; D013154:Spleen / Q000196:embryology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum