[Comparison of an aceclidine tremor with arecoline and nicotine ones in rats of different ages].
A comparative characterization of a tremor produced by aceclidine (0.5--200 mg/kg), arecoline (1--30 mg/kg) and nicotine (0.1--8 mg/kg) in rats of different age is given and the influence on the tremor of atropine sulphate (1--100 mg/kg) and scopolamine hydrobromide hydrobromide (2.5 mg/kg) described. The common character of effects produced by aceclidine and arecoline was ascertained. The tremor develops in rats aged 7--8 days and its maximum duration is in rattlings of junior and medium age. M-cholino-lytics either prevent or alleviate the tremor, lacrimation and salivation induced by aceclidine or arecoline in rats of all age categories. The aceclidine model is recommended for studying the central and peripheral M-cholinergic processes in rats of various age groups.
D000367:Age Factors; D000818:Animals; D001115:Arecoline / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D005260:Female; D008297:Male; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011812:Quinuclidines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced*
D011812:Quinuclidines; D001115:Arecoline; D009538:Nicotine; D001285:Atropine; D012601:Scopolamine
Sopostavlenie atseklidinovogo tremora s arekolinovym i nikotinovym u krys raznogo vozrasta.