[The effect of the rauwolfia-alkaloids ajmaline, rescinnamine and reserpine on the catecholamine contents of the heart (author's transl)].
The effect of three rauwolfia-alkaloids and two semi-synthetic derivatives on the catecholamine content of the hearts of guinea pigs was examined. The substances were: ajamaline, N-methyl-ajamaline, N-n-propylajmaline, rescinnamine and reserpine. The presence of catecholamines in isolated atria was tested with tyramine (10(-5) g/ml). Rescinnamine and reserpine depleted the hearts of catecholamines, ajmaline and its derivatives did not.
D000404:Ajmaline / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology; D046948:Secologanin Tryptamine Alkaloids / Q000494:pharmacology*; D014439:Tyramine
D002395:Catecholamines; D046948:Secologanin Tryptamine Alkaloids; D000404:Ajmaline; D012110:Reserpine; D014439:Tyramine
Die Wirkung der Rauwolfia-Alkaloide Ajmalin, Rescinnamin und Reserpin auf den Katecholamingehalt des Herzens