The effects of narcotics on fetal acid base status.
This paper reports two randomized control trials on the effects of nalorphine, pethidine, morphine and heroin on fetal and maternal acid base status. The drugs decreased pH and increased pCO2 in the mother, and decreased pH and base excess in the fetus. The changes in the fetus were independent of the changes in the mother. In equivalent dosages, nalorphine increased maternal pCO2 more than pethidine and morphine. The effects of heroin were found to be greater than that of other drugs, and we suggest that heroin should be avoided where the fetus is already at risk.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000187:drug effects*; D003932:Heroin / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008431:Maternal-Fetal Exchange; D008614:Meperidine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009269:Nalorphine / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects / Q000494:pharmacology*; D011247:Pregnancy
D009294:Narcotics; D002245:Carbon Dioxide; D003932:Heroin; D009020:Morphine; D008614:Meperidine; D009269:Nalorphine