Dystonic reactions following neuroleptics: time course and proposed mechanisms.
The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergic-cholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.
D000109:Acetylcholine / Q000378:metabolism; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000097:blood; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009129:Muscle Tonus / Q000187:drug effects*; D009135:Muscular Diseases / Q000139:chemically induced*; D010640:Phenothiazines / Q000009:adverse effects; D013997:Time Factors
D014150:Antipsychotic Agents; D010640:Phenothiazines; D000109:Acetylcholine; D004298:Dopamine