Evaluation of cimetidine (tagamet). An antagonist of hydrochloric acid secretion.
Cimetidine, a potent H2-receptor antagonist, has been introduced for the treatment of various conditions associated with acid peptic digestion in the gastrointestinal tract. Preliminary results are encouraging. Adverse reactions do not appear to be substantial; however, the effect of long-term use has yet to be ascertained.
D004341:Drug Evaluation; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006146:Guanidines / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy*; D012636:Secretory Rate / Q000187:drug effects
D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles