[Comparative study of a factor-VIII inhibitor in a non-hemophylic patient and in a patient with hemophylia A gravis].
In this study, we tried to make a comparison between the findings concerning two human strong anti Factor VIII inhibitors. In one case, the strong inhibitor appeared in an old man without any particular antecedant. In the second case, it occurred in a young hemophiliac A. We found in both cases that the inhibitor was a immunoglobulin G with light chain lambda. Its activity site is on the fragment AB. These anticoagulants have a inhibitory action against only the Factor VIII procoagulant fraction and have exclusively neutralising properties. The inhibitor present in the non hemophiliac patient has particularly great resistance to temperature and pH variations.
D000328:Adult; D000368:Aged; D001769:Blood; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007140:Immunoglobulin Fab Fragments / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007700:Kinetics; D013696:Temperature
D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains; D005169:Factor VIII
Etude comparative d'un inhibiteur du facteur viii chez un malade non hémophile et chez un malade hémophile A gravis.