Suppressor cells in the embryonic thymus mediate allograft tolerance.
Thymus cells from non-immunized young chickens suppress the allograft rejection in lightly irradiated syngeneic or allogeneic recipients and mediate longlasting skingraft survival in a significant proportion of recipients across a strong histocompatibility difference. Suppressive activity of this kind is already found in the embryonic thymus and is therefore believed to mediate also self tolerance and neonatal allograft tolerance.
D000367:Age Factors; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002642:Chick Embryo; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000032:analysis / Q000276:immunology; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous