Influence of a new virostatic compound on the induction of enzymes in rat liver.
The virostatic compound N,N-diethyl-4-[2-(2-oxo-3-tetradecyl-1-imidazolidinyl)-ethyl]-1-piperazinecarboxamide-hydrochloride (5531) was analyzed as to its effect on the induction of tryptophan-pyrrolase and tyrosineaminotransferase in rat liver. 1. The basic activity of the enzymes was not influenced by the substance either in normal or in adrenalectomized animals. 2. The induction of the enzymes by cortisone increased in the presence of the compound whereas the substrate induction remained unchanged. 3. The induction of tyrosine-aminotransferase by dexamethasonephosphate in tissue culture is inhibited if the dose of compound 5531 is higher than 5 mug/ml.
D000315:Adrenalectomy; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003348:Cortisone / Q000494:pharmacology; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D007093:Imidazoles / Q000494:pharmacology; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014366:Tryptophan Oxygenase / Q000378:metabolism; D014443:Tyrosine / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000378:metabolism
D000998:Antiviral Agents; D007093:Imidazoles; D010879:Piperazines; D014443:Tyrosine; D014366:Tryptophan Oxygenase; D014444:Tyrosine Transaminase; D003348:Cortisone