[Local anesthesia and beta receptor blockers in dentistry. (Study on an injectable combination of lidocaine and betadrenol)].
A double blind trial was undertaken to determine whether the addition of the beta-receptor blocker Betadrenol in two different doses to a lidocaine solution containing adrenaline could influence the exogenous and endogenous beta-adrenergic effects in the field of dental interventions under local anesthesia. It could be shown that already very small amounts of the beta-receptor blocker Betadrenol could suspend beta-adrenergic stimulation of the heart and so prevent unwanted circulatory reactions without side effects on the central nervous system.
D000319:Adrenergic beta-Antagonists; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004837:Epinephrine; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008012:Lidocaine
D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D008012:Lidocaine; D004837:Epinephrine
Lokalanästhesie und Beta-Rezeptorenblocker in der Zahnheilkunde (Untersuchungen über ein injizierbares Kombinationspräparat aus Lidocain und Betadrenol).