Cathepsin D activity in isolated odontoblasts.
The presence of an acid proteinase with a high activity has been demonstrated in isolated odontoblast-predentine material from dentinogenically active rat incisors. The enzyme was identified as cathepsin D (EC 3.4.23.5). The possible significance of the enzymatic degradation of proteoglycans and glycosaminoglycans in the course of the calcification process is discussed.
D000818:Animals; D002403:Cathepsins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003545:Cysteine / Q000494:pharmacology; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007180:Incisor / Q000201:enzymology; D007460:Iodoacetamide / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009804:Odontoblasts / Q000201:enzymology*; D010436:Pepstatins / Q000494:pharmacology; D051381:Rats; D013696:Temperature
D010436:Pepstatins; D002403:Cathepsins; D003545:Cysteine; D007460:Iodoacetamide