Binding of bile acids to cholestyramine at gastric pH conditions.
The binding of bile salts to cholestyramine was studied under varying conditions of pH and added electrolyte. The taurine-conjugated bile salts were strongly absorbed by the anion-exchange resin at low pH and in the presence of chloride anions. Glycocholic acid binding was very weak at low pH but increased strongly with increasing pH. The presence of chloride ions strongly decreased the amount of glycocholate bound by the anion-exchange resin.
D000327:Adsorption; D001647:Bile Acids and Salts / Q000378:metabolism*; D002792:Cholestyramine Resin / Q000378:metabolism*; D003840:Deoxycholic Acid / Q000378:metabolism; D006000:Glycocholic Acid / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D013656:Taurocholic Acid / Q000378:metabolism
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D002792:Cholestyramine Resin; D013656:Taurocholic Acid; D006000:Glycocholic Acid