Discriminable effects of benzodiazepines.
In a shock-escape T-maze task, rats rapidly discriminated diazepam, flurazepam and chloridazepoxide from no drug. The discriminable effects of these benzodiazepines were not completely interchangeable with those of barbiturate anesthetics. The dose-response curve for diazepam asymptoted over the range 15 to 100 mg/kg, ip whereas dose-response curves for flurazepam and chloridazepoxide were more linear.
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D005479:Flurazepam / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001463:Barbiturates; D002707:Chlordiazepoxide; D005479:Flurazepam; D003975:Diazepam