Lysosomal and ATP changes after renal-stalk clamping in rats. I. Protective action of Trasylol.
The action of Trasylol on the lysosomal and ATP changes after renal-stalk clamping in rats was examined. It was found that, in the presence of an effective Trasylol concentration, a distinct stabilization of the lysosomal membrane can be detected after 30 min of renal-stalk clamping. It was also found that there is only an indirect relationship between lysosomal changes and ATP metabolism under the action of Trasylol. The more rapid regeneration of the ATP is a result of the better microcirculation. The results confirm the earlier belief that Trasylol acts primarily on the lysosomal membrane.
D000135:Acid Phosphatase / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002403:Cathepsins / Q000378:metabolism; D002553:Cerebroside-Sulfatase / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D007511:Ischemia / Q000201:enzymology / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply*; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008833:Microcirculation; D051381:Rats; D012769:Shock / Q000201:enzymology
D000255:Adenosine Triphosphate; D007611:Aprotinin; D000135:Acid Phosphatase; D002553:Cerebroside-Sulfatase; D005966:Glucuronidase; D002403:Cathepsins