Ergoline congeners as potential inhibitors of prolactin release. 3. Derivatives of 3-phenylpiperidine.
In a continuation of our attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure, we have prepared several derivatives of 3-phenylpiperidine. These congeners have been evaluated for inhibition of prolactin release in vivo and are for the most part inactive.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D004873:Ergolines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011389:Prolactin Release-Inhibiting Factors / Q000138:chemical synthesis*; D051381:Rats
D004873:Ergolines; D010880:Piperidines; D011389:Prolactin Release-Inhibiting Factors