Effect of progestins on androgen delta4-3-ketosteroid-5alpha-A-ring reductase system in rat oral mucosa.
Rat oral mucosa microsomal delta4-3-ketosteroid-5alpha-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000735:Androstenedione / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D007700:Kinetics; D008525:Medroxyprogesterone / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology; D009061:Mouth Mucosa / Q000201:enzymology* / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000031:analogs & derivatives
D009243:NAD; D013739:Testosterone; D000735:Androstenedione; D009249:NADP; D010088:Oxidoreductases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D008525:Medroxyprogesterone