Corneal transplantation reaction in avascular keratoconus patients due to HLA-associated immune aberration against infection. A hypothesis.
HLA-B12 and HLA-B27 appeared to be characteristic of avascular keratoconus patients at risk of developing a corneal allograft reaction, which was mainly of late type and triggered by a nasopharyngeal infection. Equally incompatible grafts to patients with HLA-B5 had an uneventful course. This may be inference to the role of HLA-associated immune resistance factors, which necessitate the search for histocompatible corneal grafts also for avascular recipients bearing such indicators of risk.
D003315:Cornea / Q000276:immunology; D016039:Corneal Transplantation; D006087:Graft vs Host Reaction; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007640:Keratoconus / Q000276:immunology / Q000601:surgery*; D010641:Phenotype; D011183:Postoperative Complications; D012306:Risk; D014184:Transplantation, Homologous
D006680:HLA Antigens; D006649:Histocompatibility Antigens