Thymic humoral factor in the assessment of T lymphocytics in a patient with T cell chronic lymphocyte leukemia.
Peripheral blood lymphocytes from a patient with T cell chronic lymphocytic leukemia were examined by a combination of cell markers (E and M rosettes, and surface Ig), the graft-vs.-host reaction, thymic humoral factor (THF) and scanning electron microscopy. It was not possible, at first, to determine by conventional methods whether the leukemic cells were of the B or T type, but the THF and graft-vs.-host reaction showed that T cell precursors were present. These cells were incompetent immature T cells that underwent maturation following treatment with THF. Three months later, the T cell nature of the disease was clearly demonstrated by the E rosette technique, although at this time the cells were no longer influenced by THF.
D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000648:ultrastructure; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects*; D013951:Thymus Hormones / Q000494:pharmacology*
D013951:Thymus Hormones