[Possible structural-functional organization of the system of local cerebral blood flow regulation].
rCBF under normal conditions in the rabbit, cat, and monkey brain was found to have a spontaneous periodicity while rCBF responses to afferent flicker stimulation usually revealed a double-phasic fluctuative pattern. This suggests that the rCBF regulatory system consists of not less than two regulatory chains with different time constants, and a feedback. The data on cerebral vascular responses to microapplication of mCSF solutions with various pH, potassium and catecholamines concentrations, suggest that rapid regulatory chains may be conditioned by potassium and neurogenic vascular effects, while slow ones could be mediated by CO2 and related pH changes.
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D002415:Cats; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D000882:Haplorhini; D006439:Hemodynamics / Q000187:drug effects; D006859:Hydrogen / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008251:Macaca; D009638:Norepinephrine / Q000494:pharmacology; D010313:Partial Pressure; D010775:Photic Stimulation; D010841:Pia Mater / Q000098:blood supply; D011188:Potassium / Q000494:pharmacology
D006859:Hydrogen; D011188:Potassium; D009638:Norepinephrine
O vozmozhnoĭ strukturno-funktsional'noĭ organizatsii sistemy reguliatsii mestnogo mozgovogo krovotoka