Inhibitory effect of immobilization stress on depression of liver tyrosine aminotransferase and tryptophan pyrrolase by glucose feeding in rats.
In alloxan diabetic rats a stimulatory effect of stress on the activity of liver phosphoenolpyruvate carboxykinase seems to be very likely. In intact animals the inhibitory effect of glucose feeding (15% glucose instead of laboratory diet and water) on the activity of liver tyrosine aminotransferase (TAT) and tryptophan pyrrolase was reconfirmed. Moreover, a reversal of this effect by immobilization for 2.5 h was observed. After a mean intake of 5.3 g glucose/100 g body weight during 16 h this reversal was only partial and after 3.4 glucose/100 g during the same time the glucose effect was abolished. Stimulation of both enzymes by corticosterone and of TAT by stress-induced release of glucagon may play a role in this reversal.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology; D005947:Glucose / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009043:Motor Activity; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D051381:Rats; D013312:Stress, Physiological / Q000201:enzymology*; D014366:Tryptophan Oxygenase / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism*
D014366:Tryptophan Oxygenase; D014444:Tyrosine Transaminase; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D005947:Glucose