[Treatment of peptic ulcer in the Zollinger-Ellison syndrome with histamine H2-receptor antagonists (author's transl)].
Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four patients after treatment lasting from six weeks to four-and-a-half-months. Two patients developed recurrent ulcer after the treatment had stopped, but responded to a second course. One patient developed hepatitis B during cimetidine treatment and it is possible that the course of the hepatitis was unfavourable affected by cimetidine. But no other side effects were noted nor was there a significant change in basal serum-gastrin concentration or an increase in H+ secretion. Total gastrectomy remains the treatment of choice in Zollinger-Ellison syndrome, but cimetidine should be considered if the patient refuses operation or operation is not feasible because of a poor general state.
D000328:Adult; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005755:Gastrins / Q000097:blood; D006509:Hepatitis B / Q000139:chemically induced; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008785:Metiamide / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy*; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000150:complications*
D005755:Gastrins; D006635:Histamine H2 Antagonists; D008785:Metiamide; D002927:Cimetidine
Behandlung peptischer Ulzera beim Zollinger-Ellison-Syndrom mit Histamin-H2-Rezeptor-Antagonisten.