[Effect of antimediator preparations on the intercellular relations in early embryos of the sea urchin].
The dated treatment of the early embryos of an irregular (flat) sea urchin Scaphechinus mirabilis by neuropharmacological drugs (anti-neurotransmitters) during one of the first four cleavage divisions results in the impairment of intercellular connections and leads to the formation of twin embryos, dwarf embryos, embryos of the dumb-bell shape etc. In the experiments with some of the drugs under study such developmental abnormalities were not seen or were expressed much more weakly when serotonin or bufotenin (N,N-dimethylserotonin) were added to the medium. A suggestion is put forward that the early embryos possess an intracellular mechanism participating in the interaction between the cells and operating via endogenous monoamines, primarily serotonin.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors*; D012617:Sea Urchins / Q000187:drug effects* / Q000196:embryology; D013997:Time Factors
D018377:Neurotransmitter Agents
Vliianie preparatov-antimediatorov na mezhkletochnye sviazi u rannikh zarodysheĭ morskikh ezheĭ.