[Toxico-pharmacologic study of a curarimimetic, AH 8165, in relation to storage time].
The toxicological and pharmacological study of a non depolarizing curariform drug AH 8165 was performed under various conditions of storage, duration and temperature (duration: 1 month 2 years; temperature: 4 degrees C to 70 degrees C). It shows that this drug ought to be kept a low temperature for storage (in the range of + 4 degrees C). In the sam way, this study demonstrates a better stability of this drug when stored lyophilized form instead of a solute. The interest of standardized animal experimentation in studying the activity of a therapeutic substance depending on the duration of storage is shown.
D000818:Animals; D004355:Drug Stability; D004356:Drug Storage; D005260:Female; D008297:Male; D051379:Mice; D011726:Pyridinium Compounds / Q000592:standards* / Q000633:toxicity; D013997:Time Factors
D011726:Pyridinium Compounds
Etude toxico-pharmacologique d'un curarimimétique, le AH 8165, en fonction du vieillissement