Biotransformation of drugs: quantitative structure-activity relationships for barbiturates, tertiary amines, and substituted imidazoles.
When using free energy-related physicochemical parameters, stimulation of NADPH oxidation by barbiturates and the N-oxidation of tertiary amines was found to be primarily dependent upon the lipophilic character of the substrates as measured by log P, where P is the partition coefficient from either 1-octanol-water or corn oil-water solvent systems. In contrast, the inhibition of epoxidation of aldrin by a series of substituted imidazoles appears to be much more dependent on electronic (sigma) and steric (Es) effects of the inhibitors.
D000452:Aldrin / Q000378:metabolism; D000588:Amines / Q000378:metabolism*; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001711:Biotransformation; D002417:Cattle; D007093:Imidazoles / Q000494:pharmacology*; D007700:Kinetics; D008862:Microsomes, Liver / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D051381:Rats; D012044:Regression Analysis; D013329:Structure-Activity Relationship; D013552:Swine; D013816:Thermodynamics
D000588:Amines; D001463:Barbiturates; D007093:Imidazoles; D009249:NADP; D000452:Aldrin