A dual action of 5-hydroxytryptamine on the ovarian suspensory ligament of the rat.
5-Hydroxytryptamine has a dual effect on the spontaneously contracting rat ovarian ligament, in vitro, a contraction which is antagonized by the prior administration of methysergide and a relaxation of the ligament observed in the methysergide-treated preparation. The relaxatory effect was not antagonized by propranolol or tetrodotoxin but treatment of the ligament with indomethacin abolished this response. Prostaglandins of the E series produced an inhibition, and PGF2alpha a contraction of the ligament. Thin layer chromatographic separation indicates that 5-HT causes the release of a PGE2-like substance which relaxes the ovarian suspensory ligament.
D000290:Adnexa Uteri / Q000187:drug effects*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008784:Methysergide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D011453:Prostaglandins / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D012701:Serotonin; D008784:Methysergide