Further evidence implicating E-type prostaglandins in the patency of the lamb ductus arteriosus.
A blocker of prostaglandin (PG) snythesis, indomethacin, given to pregnant ewes near term produces constriction of the lamb ductus arteriosus in utero. The result supports the hypothesis formulated previously that E-type prostaglandins, which are potent relaxant on the ductus, are responsible for maintaining the patency of the vessel during foetal life.
D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide / Q000097:blood; D004373:Ductus Arteriosus / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000097:blood / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011458:Prostaglandins E / Q000502:physiology*; D012756:Sheep
D011458:Prostaglandins E; D002245:Carbon Dioxide; D010100:Oxygen; D007213:Indomethacin