[Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions].
Cytochemical electron microscopy was employed to study the content of neurotransmitters in the synaptic vesicles of adrenergic nerve fibers of Vas deferens of the rat following depletion of the meadiator's reserves by tyramine and subsequent accumulation of exogenous norepinephrine. Subject to investigation was also the effect of antidepressants (phthoracizine and imipramine) on the accumulation of exogenous norepinephrine in the synaptic vesicles. Phthoracizine and imipramine (1 and 10 gamma/ml) are shown to block the acculation of norepinephrine in the vesicles, when the mediator is introduced in a concentration of 0,5 gamma/ml, and not to impede this process, if the mediator's concentration is increased to 30 gamma/ml.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D018377:Neurotransmitter Agents / Q000032:analysis*; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D010640:Phenothiazines; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013572:Synaptic Vesicles / Q000032:analysis* / Q000378:metabolism; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology; D014649:Vas Deferens / Q000294:innervation
D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D010640:Phenothiazines; D011941:Receptors, Adrenergic; D007099:Imipramine; D009638:Norepinephrine; D014439:Tyramine
Soderzhanie neĭromediatora v sinapticheskikh puzyr'kakh adrenergicheskikh nervov krysy pri nekotorykh farmakologicheskikh vodeĭstviiakh