Structure activity relation for some 1,4-benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED50.
Significant correlation in 11 different 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the "azepinones" by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carobnyl group at the receptor site.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001894:Borohydrides; D007700:Kinetics; D051379:Mice; D010084:Oxidation-Reduction; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D001570:Benzodiazepinones; D001894:Borohydrides; D010433:Pentylenetetrazole