Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.
D000818:Animals; D002846:Chromatography, Affinity; D002942:Circular Dichroism; D004351:Drug Resistance; D007939:Leukemia L1210 / Q000201:enzymology*; D008727:Methotrexate; D008970:Molecular Weight; D009249:NADP; D013056:Spectrophotometry, Ultraviolet; D013762:Tetrahydrofolate Dehydrogenase / Q000302:isolation & purification; D014364:Tryptophan / Q000032:analysis
D009249:NADP; D014364:Tryptophan; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate