Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. III. Analysis of genes governing the expression of regulatory T cell activity.
Recombinant-inbred strains of mice, as well as the progenitor strains from which they were derived, were evaluated with respect to the capacity of B cells to respond to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) and the amount of suppressor and amplifier T cell activity present. None of these functional activities was found to be linked to genes within the major histocompatibility (H-2) or the IgCH allotype complex, and several autosomal genes appeared to govern the expression of each of these characteristics.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D007108:Immune Tolerance; D007126:Immunoglobulin Allotypes; D008297:Male; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011995:Recombination, Genetic; D013296:Streptococcus pneumoniae / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens; D007126:Immunoglobulin Allotypes; D011135:Polysaccharides, Bacterial