[Effect of psychotropic preparations on the activity of Ca- and Mg-dependent ATPase of the sarcoplasmic reticulum].
In sarcoplasmic reticulum of rabbit skeletal muscles the activity of Ca2+, Mg2+- dependent ATPase was distinctly inhibited under effect of neuroleptic drugs - derivatives of phenothiazine and butyrophenone. The effect of tricyclic antidepressants was less pronounced. Tranquilizers (derivatives of 1,4-benzodiazepine) inhibited the enzyme, but trioxazin was only slightly active. High concentrations of lithium salts and of psychostimulants caffeine and corasole were found to stimulate the Ca2+, Mg2+-ATPase activity; low concentrations of the substances slightly inhibited the enzyme. The blocking effect of psychotropic drugs was more distinct, if the enzyme preparations were previously treated with ATP.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001569:Benzodiazepines; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D009132:Muscles / Q000166:cytology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D010640:Phenothiazines; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010640:Phenothiazines; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D002110:Caffeine; D000251:Adenosine Triphosphatases; D008274:Magnesium; D002118:Calcium; D010433:Pentylenetetrazole
Vliianie psikhotropnykh preparatov na aktivnost' Ca, Mg-zavisimoĭ ATF-azy sarkoplazmaticheskogo retikuluma