Failure of benzoctamine to influence the activity of rat striatum tyrosine-hydroxylase.
The influence of benzoctamine (Tacitin) on rat striatum tyrosine-hydroxylase was analized. Injection of 100 mg benzoctamine/kg body weight caused no alteration in the tyrosine-hydroxylase activity whilst a decrease of about 60% in the activity was recorded after treatment with a-methyl-p-tyrosine a known inhibitor of tyrosine-hydroxylase. The present results differ from those of Maitre et al. which indicated that benzoctamine inhibited tyrosine-hydroxylase activity.
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D003342:Corpus Striatum / Q000201:enzymology*; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D000873:Anthracenes; D014446:Tyrosine 3-Monooxygenase