Anion transport and membrane morphology.
Freeze-fracture electronmicroscopy has been used to examine the membrane ultrastructure of human red blood cells in the presence of inhibitors of chloride exchange. The extent of inhibition was correlated with a decrease of intramembrane particle density on the B-fracture face. Dimethylsulfoxide (DMSO) and glycerol, which markedly and reversibly reduced the intramembrane particle density, were shown to drastically and reversibly inhibit chloride self-exchange. DMSO was shown to be a noncompetitive inhibitor of chloride flux.
D001692:Biological Transport / Q000187:drug effects; D000440:Butanols / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D002712:Chlorides / Q000378:metabolism*; D003408:Cresols / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D005614:Freeze Fracturing; D005990:Glycerol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D010693:Phloretin / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D000440:Butanols; D002712:Chlorides; D003408:Cresols; D012964:Sodium; D005990:Glycerol; D011188:Potassium; D010693:Phloretin; D004121:Dimethyl Sulfoxide