Repression of the tyrosine, lysine, and methionine biosynthetic pathways in a hisT mutant of Salmonella typhimurium.
A comparison was made of the repressibility of certain enzymes in the tyrosine, methionine, and lysine biosynthetic pathways in wild-type Salmonella typhimurium and a hisT mutant. The results show that (i) tyrosine represses the synthesis of the tyrosine-sensitive 3-deoxy-D-arabino-heptulsonic acid 7-phosphate synthetase and the tyrosine aminotransferase to the same extent in a hisT mutant as in wild type and (ii) there is no detectable alteration in the extent to which methionine represses O-succinylhomoserine synthetase or in the extent to which lysine represses the lysine-sensitive beta-aspartokinase as a result of the hisT mutation.
D015079:2-Isopropylmalate Synthase / Q000096:biosynthesis; D010723:3-Deoxy-7-Phosphoheptulonate Synthase / Q000096:biosynthesis; D000123:Acetyltransferases / Q000096:biosynthesis; D001222:Aspartate Kinase / Q000096:biosynthesis; D004794:Enzyme Repression; D006642:Histidinol-Phosphatase / Q000096:biosynthesis; D008239:Lysine / Q000096:biosynthesis* / Q000494:pharmacology; D008715:Methionine / Q000096:biosynthesis* / Q000494:pharmacology; D009154:Mutation; D012486:Salmonella typhimurium / Q000201:enzymology / Q000378:metabolism*; D014443:Tyrosine / Q000096:biosynthesis* / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis
D014443:Tyrosine; D008715:Methionine; D000123:Acetyltransferases; D015079:2-Isopropylmalate Synthase; D010723:3-Deoxy-7-Phosphoheptulonate Synthase; D014444:Tyrosine Transaminase; D001222:Aspartate Kinase; D006642:Histidinol-Phosphatase; D008239:Lysine