[Pharmacologic peculiarities of natural and synthetic alpha-adrenomimetics].
The mechanical response of the isolated rat vas deferens to four alpha-adrenomimetic substances has been studied. The four test substances were noradrenaline, octopamine, 2-phenylethylamine and 2-(1-naphthylmethyl)imidazoline (Privin). Examination of the cumulative dose/response curves showed both qualitative and quantitative differences. Octopamine gave an alpha value (intrinsic activity) greater than that of noradrenaline; Privin proved to be a partial agonist but with affinity greater than that of noradrenaline. Various qualitative differences were also observed suggesting a possible explanation based on labilization of the membrane.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009278:Naphazoline / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D009655:Octopamine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects
D000316:Adrenergic alpha-Agonists; D010627:Phenethylamines; D009655:Octopamine; D009278:Naphazoline; D009638:Norepinephrine
Peculiarità farmacologiche di sostanze alpha-adrenomimetiche naturali e innaturali.