Influence of pH and temperature on behaviour of surfactant from human neonatal lungs.
The surface pressures of human surfactant films were measured under static conditions and under dynamic (expansion-compression) conditions. The results from both methods showed that the maximum surface pressures generated by surfactant films in vitro were strongly dependent on temperature throughout the range 29-41 degrees C, higher pressures being achieved at the lower temperatures. In contrast, increasing the pH of the subphase stepwise over the range 7.1-7.7 produced a modest fall in the maximum pressures exerted by the films. The possibility that surfactant films may behave in a similar manner in vivo is discussed.
D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D011312:Pressure; D011663:Pulmonary Surfactants / Q000502:physiology*; D013696:Temperature
D011663:Pulmonary Surfactants