Treatment of phenothiazine-induced dyskinesia.
Previous experience indicated the possibility that a serotonin antagonist substance, was effective in relieving dyskinesia as a reaction to phenothiazine antipsychotic drugs. Since the substances used in the original observations did not become available on the United States market, a compound known to be a serotonin antagonist, cyproheptadine, which was readily available and safe, was used to treat three patients who had phenothiazine-induced dyskinesia. In these patients, cyproheptadine was definitely effective in relieving the dyskinesia over an extended period of time. Further controlled studies are required to confirm this report.
D014150:Antipsychotic Agents / Q000009:adverse effects*; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced / Q000188:drug therapy*; D010640:Phenothiazines
D014150:Antipsychotic Agents; D010640:Phenothiazines; D003533:Cyproheptadine