The effect of miotics on the intraocular pressure of conscious owl monkeys.
The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. Locally applied pilocarpine, carbachol, and oxotremorine gave concentration-related reduction in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. Slight reductions were also observed with aceclidine and R. S. 86. These results are discussed in relation to the effects of miotics in man.
D000772:Anesthesia, Local; D000818:Animals; D001029:Aotus trivirgatus; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008916:Miotics / Q000494:pharmacology*; D010095:Oxotremorine / Q000494:pharmacology; D010277:Parasympathomimetics; D010862:Pilocarpine / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D013141:Spiro Compounds / Q000494:pharmacology; D013388:Succinimides / Q000494:pharmacology; D014065:Tonometry, Ocular
D008916:Miotics; D010277:Parasympathomimetics; D011812:Quinuclidines; D013141:Spiro Compounds; D013388:Succinimides; D010862:Pilocarpine; D010095:Oxotremorine; D002217:Carbachol