[Treatment of exocrine pancreatic insufficiency with fungal lipase (author's transl)].
7 patients suffering from severe exocrine pancreatic insufficiency have been treated with a lipolytic enzyme extracted from Rhizopus arrhizus. Comparing the fungal lipase with a placebo the drug lowered the daily stool weight from 809 g to 443 g on an average, i.e. by 45.2%. The steatorrhea was reduced from 75.6 g/24 h to 32.9 g, i.e. by 56.5%. When incubating the enzyme in vitro in saline solutions of different pH for 1 h the loss of lipolytic activity is 13% at pH 5, 15% at pH 4, and 19% at pH 3. So the enzyme, like fungal proteases, is almost not altered by hydrochloric acid at concentrations found physiologically in the stomach.
D002446:Celiac Disease / Q000188:drug therapy; D002908:Chronic Disease; D004341:Drug Evaluation; D005243:Feces / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008049:Lipase / Q000627:therapeutic use*; D010180:Pancreatectomy; D010182:Pancreatic Diseases / Q000188:drug therapy*; D010195:Pancreatitis / Q000188:drug therapy; D012008:Recurrence; D012233:Rhizopus / Q000201:enzymology
D008049:Lipase
Die Behandlung der exokrinin Pankreasinsuffizienz mit einer säurestabllen Pilzlipase