[Effects of pH on the processes of excitation-contraction coupling of bullfrog atrium (author's transl)].
It has long been demonstrated that in cardiac muscle alterations in the extracellular pH exhibit a remarkable inotropic effect, whereas the precise mechanism is not fully clarified yet in spite of many associated thories. In recent years, however, abundant informations about the processes of excitation-contraction coupling (E-C coupling) of cardiac muscle have been obtained. Accordingly, the mechanisms of inotropic actions of pH on cardiac muscles must also be re-examined on the basis of these lately developed theories of E-C coupling. In the present experiment, therefore, we attempted to elucidate the fundamental mechanism of actions of pH upon several processes of E-C coupling using the bullfrog atrium whose processes of E-C coupling have been fairly well known...
D000200:Action Potentials; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007474:Ion Exchange; D008564:Membrane Potentials; D008931:Mitochondria, Muscle / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects; D011892:Rana catesbeiana; D012519:Sarcoplasmic Reticulum / Q000502:physiology; D012964:Sodium / Q000502:physiology
D002110:Caffeine; D012964:Sodium; D002118:Calcium