Determination of the metabolites of bezitramide in urine. II. The basic metabolite.
A high-performance liquid chromatographic method for the determination of low levels (less than 1 microgram/ml) of the basic metabolite of bezitramide, 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, in human urine is described. Special attention is given to the separation from the basic metabolite of droperidol, a drug frequently co-administered with bezitramide.
D000700:Analgesics / Q000652:urine*; D014150:Antipsychotic Agents / Q000652:urine; D001562:Benzimidazoles / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D004329:Droperidol / Q000652:urine; D006801:Humans; D006868:Hydrolysis; D008722:Methods; D010868:Pimozide / Q000031:analogs & derivatives / Q000652:urine; D010880:Piperidines / Q000652:urine*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000700:Analgesics; D014150:Antipsychotic Agents; D001562:Benzimidazoles; D010880:Piperidines; D010868:Pimozide; C004461:bezitramide; D004329:Droperidol