Within-patient comparisons between different anti-hypertensive drugs.
1. By substituting one anti-hypertensive drug for the other in a panel of hypertensive patients equipotent doses have been determined. 2. Thus 40 mg of propranolol is equivalent to 4-5 mg of pindolol, 98 mg of practolol, 128 mg of alprenolol, 49 mg of metoprolol, 42 mg of tolamolol and 4-4 mg of timolol. 3. Bendorfluazide (10 mg) is eqivalent to 1-6 mg of bumetanide, 20 mg of chlorthalidone, 35 mg of mefruside and 3-5 mg of amiloride together with 35 mg of hydrochlorthiazide. 4. Methyldopa (250 mg) is equivalent to 6-0 mg of debrisoquine and 0-5 mg of St 600 (Boehringer), which is a clonidine-like substituted imidazoline.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006973:Hypertension / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D004232:Diuretics