[Mechanism of induction of tyrosine in rat liver by phenothiazine derivatives and related chemical compounds].
Increase of hepatic tyrosine-alpha-ketoglutarate transaminase is observed in Rats (Wistar strain) after intraperitoneal administration of tricyclic compounds (phenothiazin and related structure derivatives). This is an induction process: actinomycine D inhibits this effect. This action is not mediated by glucocorticoids: induction persists in adrenalectomized Rats. The mechanism of action is different too: additive effects are found after simultaneous injection of glucocorticoid and tricyclic drug.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D010640:Phenothiazines / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D014444:Tyrosine Transaminase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D004338:Drug Combinations; D010640:Phenothiazines; D003609:Dactinomycin; D014444:Tyrosine Transaminase; D011398:Promethazine; D002746:Chlorpromazine; D006854:Hydrocortisone
Approche du mécanisme d'induction de la tyrosine transaminase de foie de Rat par des dérivés phénothiaziniques et chimiquement apparentés.