New evidence for growth hormone modulation by the alpha-adrenergic system in man.
The effect of BS 100-141, N-amidino 2-(2.6 dichlorophenyl) acetamide hydrochloride, a new drug with central alpha-adrenoceptor activity, on growth hormone (GH) secretion was investigated in 24 young, healthy volunteers. Six normal volunteers were treated with 1 mg and 8 with 2 mg BS 100-141; 8 of these 14 were treated with placebo, using single oral doses. Ten normal volunteers received single oral doses of 2 and 4 mg BS 100-141, 0.15 and 0.30 mg clonidine in a randomized, crossover study. GH secretion was significantly increased after 2 and 4 mg BS 100-141 and 0.30 mg clonidine. Prolactin and insulin plasma levels, glycerol, and blood sugar were not significantly influenced by BS 100-141. The results give new evidence for an alpha-adrenoceptor mechanism modulating GH secretion in normal young men.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000494:pharmacology; D005990:Glycerol / Q000097:blood; D013006:Growth Hormone / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D010919:Placebos; D011388:Prolactin / Q000097:blood; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D001786:Blood Glucose; D006146:Guanidines; D007328:Insulin; D010648:Phenylacetates; D010919:Placebos; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011388:Prolactin; D013006:Growth Hormone; D003000:Clonidine; D005990:Glycerol