The effects of nalorphine and naloxone on maternal and fetal blood gas and pH.
In the control trials on near-term pregnant women before the onset of labour, nalorphine was found to cause a mild respiratory acidosis in the mother and metabolic acidosis in the fetus. These effects were not apparent when naloxone was administered.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D001769:Blood / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood*; D002986:Clinical Trials as Topic; D005260:Female; D005312:Fetal Blood / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009269:Nalorphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy
D002245:Carbon Dioxide; D009270:Naloxone; D010100:Oxygen; D009269:Nalorphine