[Influence of the Benzodiazepine-derivative Ro 06-9098/000 on choreo-athetotic syndromes (author's transl)].
Five patients suffering from choreo-athetotic syndromes of different genesis were treated with the benzodiazepine-derivative Ro 06-9098/000 (7-Nitro-1(methylmethoxy)-1,3-dihydro-5-phenyl-2 H-1,4-benzodiazepin-2-one). The existing hyperkinesias could be well influenced in four cases of male patients, sufficiently in one case of a female patient. The sedative effect, accompanied by a muscle hypotonia appearing simultaneously under the medication, did not represent and essential limiting factors at the chosen dose of 5--20 mg/die. The observed successes in therapy point at the result and effect of benzodiazepine derivatives on extra-pyramidalmotoric hyperkinesias which got little attention until now.
D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000627:therapeutic use*; D002819:Chorea / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy; D006948:Hyperkinesis / Q000188:drug therapy; D008297:Male
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones
Beeinflussung choreo-athetotischer Syndrome mit dem Benzodiazepin-Derivat Ro 06-9098/000.