[Studies on the activities of peptidases from human leucocytes, and human and guinea pig alveolar macrophages (author's transl)].
Peptidases activities were compared in human leucocytes, guinea pig and human alveolar macrophages. Seversl endo- and exopeptides were characterized; some of them were active at acid pH and others at neutral and alkaline pH. Leucocytes and alveolar macrophages had proteolygic activity for hemoglobin, fibrinogen, collagen and elastin. Using synthetic substrates, several enzymes were characterized: arylamidase, aminopeptidase, carboxypeptidases A and B and cathepsins A and C. The enzymatic activities were much higher in alveolar macrophages than in leucocytes.
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology*; D008168:Lung / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*
D010447:Peptide Hydrolases
Etude des activités de peptidases des leucocytes humains et des macrophages alvéolaires de l'homme et du cobaye