The activation of intravascular coagulation by bromocarbamide.
In the rabbit the application of a non-lethal, sleep-inducing dose of bromisovalerianyl carbamide (0.5 g/kg body weight) causes an activation of the coagulation system. This activation is manifested by shortened thrombin and partial thromboplastin times and a decrease of fibrinogen concentration and Factor V activity. In contrast, pentobarbital sodium at a dose (62.5 mg/kg) which causes the same changes in arterial partial oxygen pressure and arterial pH does not influence the coagulation system. The bromocarbamide-induced changes in the coagulation system are not to be considered as a result of hypoxia and acidosis but seem to be caused by early endothelial and tissue lesions which result in the release of procoagulatory substances. In healthy test persons a single dose of 1.5 g bromisovalerianyl carbamide has no demonstrable influence on the system of hemostasis.
D000328:Adult; D000818:Animals; D001769:Blood; D001777:Blood Coagulation / Q000187:drug effects*; D001968:Bromisovalum / Q000633:toxicity*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000139:chemically induced; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011817:Rabbits; D012769:Shock / Q000097:blood / Q000139:chemically induced; D014508:Urea / Q000031:analogs & derivatives*
D001968:Bromisovalum; D014508:Urea; D010424:Pentobarbital