[Demethylation of methindione].
Methindion demethylation was shown to occur in rats. This process proceeds with the participation of NADPH-dependent transport system of microsomal electrons. In experiments in vivo methindion demethylation coursed at a high rate and was accompanied by a partial loss of its anticonvulsive effects.
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D004579:Electron Transport; D007192:Indenes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D051381:Rats; D013347:Subcellular Fractions
D000927:Anticonvulsants; D007192:Indenes; D009249:NADP
Demetilirovanie metindiona.