Effect of influenza virus on the immune responsiveness of animals.
Infection of mice with A/Hong Kong/1/68 (H3N2) and A/PR8/34 (H0N1) influenza virus strains resulted in a significant inhibition of the formation of antibody-producing cells in response to administration of sheep erythrocytes and a reduced capacity of spleen cells to induce "graft-versus-host" reaction. The immunosuppression caused by influenza infection was observed for a long period of time post infection (3--6 months). The extent of inhibition of antibody production depended on the dose of virus, route of inoculation, the sequence of infection and immunization and the internal between them. Heat-inactivated virus exerted no immunosuppressive effect.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000921:Antibody-Producing Cells / Q000276:immunology; D006087:Graft vs Host Reaction; D006358:Hot Temperature; D007114:Immunization; D007165:Immunosuppression Therapy; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000914:Antibodies, Viral