Chlorination, decarboxylation and bactericidal activity mediated by the MPO-H2O2-C1- system.
1. MPO, H2O2 and C1- form a complex that undergoes intramolecular rearrangement yielding the chlorinium ion. 2. The chlorinium ion can interact with MPO, bacteria and amino acids. 3. The reaction can occur at a wide range of pH, H2O2 concentration and C1- concentration. 4. The chlorinium ion can attack different protein molecules to cause structural changes. 5. Preincubation of MPO with bacteria results in greater bactericidal activity. 6. Diffusible bactericidal agents are also produced by the MPO-H2O2-C1- system.
D000818:Animals; D001419:Bacteria; D001426:Bacterial Proteins; D002712:Chlorides / Q000378:metabolism* / Q000494:pharmacology; D003653:Decarboxylation; D004926:Escherichia coli; D006861:Hydrogen Peroxide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D009195:Peroxidase / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D010587:Phagocytosis
D001426:Bacterial Proteins; D002712:Chlorides; D006861:Hydrogen Peroxide; D010544:Peroxidases; D009195:Peroxidase