[Regulation of lipid synthesis in animal organs].
Studies were made of the mechanisms regulating the quantity and catalytic efficiency of hepatic acetyl coenzyme A carboxylase, which plays a critical role in the control of fatty acid biosynthesis. The microsomal enzyme system responsible for the formation of phosphatidic acid, the initial step in glycerolipid biosynthesis, was resolved into two component enzymes. The acyl-donor specificities of these and other acyltransferases account for the asymmetric fatty acid distribution in naturally occurring glycerolipids.
D000103:Acetyl-CoA Carboxylase / Q000096:biosynthesis* / Q000378:metabolism; D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008025:Ligases / Q000096:biosynthesis*; D008041:Linoleic Acids / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008820:Mice, Obese / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009821:Oils / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000096:biosynthesis; D051381:Rats; D003313:Zea mays
D005227:Fatty Acids; D008041:Linoleic Acids; D008055:Lipids; D009821:Oils; D010712:Phosphatidic Acids; D000217:Acyltransferases; D005992:Glycerol-3-Phosphate O-Acyltransferase; D008025:Ligases; D000103:Acetyl-CoA Carboxylase; D007930:Leucine
Zur Regulation der Lipogenese im tierischen Organismus