The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.
The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet  aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.
D001792:Blood Platelets / Q000378:metabolism*; D004298:Dopamine / Q000097:blood*; D005475:Flupenthixol / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008968:Molecular Conformation; D010974:Platelet Aggregation / Q000187:drug effects*; D012701:Serotonin / Q000097:blood / Q000494:pharmacology*; D013237:Stereoisomerism; D013892:Thioxanthenes / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D013892:Thioxanthenes; D012701:Serotonin; D005475:Flupenthixol; D004298:Dopamine