Cytochemical demonstration of adenylate and guanylate cyclases in vascular smooth muscle of circle of Willis.
The cytochemical localization of adenylate cyclase and guanylate cyclase was studied in the arteries of the circle of Willis in dogs. The reaction products of both adenylate and guanylate cyclases were similarly distributed and selectively localized predominantly adjacent to sarcoplasmic reticulum and sparsely to mitochondria and outer nuclear membranes of vascular smooth muscles. The observations could suggest a close association of the intracellular localizations of both cyclases and the intracellular calcium storage sites, and ultimately contribute to our complete understanding of regulation of cerebral blood flow and vasospasm.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002941:Circle of Willis / Q000201:enzymology* / Q000648:ultrastructure; D004285:Dogs; D006162:Guanylate Cyclase / Q000378:metabolism*; D006651:Histocytochemistry; D009130:Muscle, Smooth / Q000201:enzymology / Q000648:ultrastructure
D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase