Inhibition by barbituric acid and its derivatives of the enzymes in rat brain which participate in the synthesis of pyrimidine ribotides.
D000818:Animals; D001221:Aspartate Carbamoyltransferase / Q000037:antagonists & inhibitors; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000037:antagonists & inhibitors; D004080:Dihydroorotase / Q000037:antagonists & inhibitors; D004081:Dihydroorotate Oxidase / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009962:Orotate Phosphoribosyltransferase / Q000037:antagonists & inhibitors; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000037:antagonists & inhibitors; D011742:Pyrimidine Nucleotides / Q000096:biosynthesis*; D051381:Rats; D012265:Ribonucleotides / Q000096:biosynthesis*; D014529:Uridine / Q000378:metabolism; D014541:Uridine Kinase / Q000037:antagonists & inhibitors; D014543:Uridine Phosphorylase / Q000037:antagonists & inhibitors
D001463:Barbiturates; D011742:Pyrimidine Nucleotides; D012265:Ribonucleotides; D004081:Dihydroorotate Oxidase; D001221:Aspartate Carbamoyltransferase; D009962:Orotate Phosphoribosyltransferase; D014543:Uridine Phosphorylase; D014541:Uridine Kinase; D004080:Dihydroorotase; D009964:Orotidine-5'-Phosphate Decarboxylase; D002222:Carbamoyl-Phosphate Synthase (Ammonia); D014529:Uridine