(1-(3-(Phenothiazin-10-yl)propyl)-4-piperidinyl)phenylmethanones, a novel class of long-acting neuroleptic agents.
In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as the end points. Most compounds were shown to be potent neuroleptic agents and two were found to possess a long duration of action.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D001362:Avoidance Learning / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010640:Phenothiazines; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology
D014150:Antipsychotic Agents; D010640:Phenothiazines; D010880:Piperidines; D003913:Dextroamphetamine