[Influence of ethanol on the in vitro and in vivo drug release from some sustained release tablets (author's transl)].
The in vitro and in vivo liberation of acetylsalicylic acid from sustained release tablets in presence of ethanol is described. Simultaneous uptake of 120 ml commercial brandy resulted in a faster release of the active substance from the tablets prepared with Eudragit ret-l (PM), as has been proved by urinary excretion data. These results were supported by experiments with a pH-endoaradio transmitter and by radiography.
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D001466:Barium Sulfate / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D001639:Bicarbonates; D003692:Delayed-Action Preparations; D013607:Tablets; D001466:Barium Sulfate; D000431:Ethanol; D001241:Aspirin
Beeinflussung der In-vitro- und In-vivo-Pharmakonfreisetzung aus einigen peroralen Depotformen unter Athanolbelastung