Methyprylon-induced bone marrow suppression in siblings. An inherited defect?
Transient bone marrow suppression in two sisters followed ingestion of the sedative-hypnotic drug methyprylon. No other pharmacologic or environmental inciting factor common to both patients was identified. The mechanisms responsible could not be defined; abnormal suppression fo granulocyte progenitors by the drug in vitro was not demonstrable. It is postulated that a pharmacogenetic interaction may have been responsible for methyprylon-related bone marrow suppression in these two siblings.
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000235:genetics; D001853:Bone Marrow / Q000187:drug effects*; D005260:Female; D006801:Humans; D010881:Piperidones / Q000009:adverse effects* / Q000627:therapeutic use; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy
D010881:Piperidones