Inhibition of glycolysis in hearts during ischemic perfusion.
Rates of glycolysis were determined in the isolated perfused rat heart under aerobic, anoxic, and ischemic conditions. The rate was accelerated in anoxic and was inhibited in ischemic tissue. Glycolytic inhibition developed at the level of glyceraldehyde-3-P dehydrogenase and was associated with accumulation of high levels of tissue lactate and H+.
D000693:Anaerobiosis; D000818:Animals; D003327:Coronary Disease / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D006019:Glycolysis; D006321:Heart / Q000503:physiopathology; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D051381:Rats
D007773:Lactates