[The hypertensive effect of adyston and etilefrin. Comparative animal experimental studies].
According to the results obtained under the described conditions it can be stated that after i.v. administration Adyston induces a dose-dependent rise in systolic and diastolic blood pressure, in comparison with etilefrin the new product Adyston shows a greater potency in rising the systolic and diastolic blood pressure; Adyston induced rise of blood pressure is in general of longer duration in comparison with that induced by etilefrin, it is interesting that in the dose of 0.01 mg/kg Adyston increases the arterial blood pressure but at the same time slightly decreases the heart rate; this is not the case after administration of etilefrin which at the same dose increases both arterial blood pressure and heart rate.
D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005039:Etilefrine / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D007022:Hypotension / Q000188:drug therapy*; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives; D010627:Phenethylamines / Q000627:therapeutic use*; D010656:Phenylephrine / Q000031:analogs & derivatives*; D011437:Propylamines / Q000627:therapeutic use*
D004338:Drug Combinations; D010627:Phenethylamines; D011437:Propylamines; C016209:norfenefrine, pholedrine drug combination; D010656:Phenylephrine; D008694:Methamphetamine; D015078:2-Hydroxyphenethylamine; D005039:Etilefrine
Zur blutdrucksteigernden Wirkung von Adyston und Etilefrin Vergleichende tierexperimentelle Untersuchungen.