[Effects of Alfatesin on total cerebral blood flow in humans].
The total cerebral blood flow was measured by the Xe 133 in 9 patients, before and during a pure Alfatesine induced anaesthesia. With a perfusion flow of 0,04 ml/kg/mn, the total flow underwent a mean fall of 38 p. 100 that was linked neither to any systemic pressure variations nor to variations of the PaCO2. This fall was linked to a cerebral arterio vasoconstriction as it was evidenced by arteriographic images.
D000293:Adolescent; D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000009:adverse effects*; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011277:Pregnanediones / Q000009:adverse effects*; D014662:Vasoconstrictor Agents
D011277:Pregnanediones; D014662:Vasoconstrictor Agents; D000530:Alfaxalone Alfadolone Mixture
Action de l'alfatésine sur le débit sanguine cérébral global chez l'homme