The effect of sickle cell haemoglobin polymerization on hydrogen ion dissociation.
An increase in hydrogen ion dissociation was found on sickling due to sickle cell haemoglobin polymerization. Since a decrease in pH favours sickling, this might enhance the sickling process in a vicious cycle.
D006441:Hemoglobin A / Q000378:metabolism; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010108:Oxyhemoglobins / Q000378:metabolism
D006451:Hemoglobin, Sickle; D010108:Oxyhemoglobins; D006441:Hemoglobin A