Antiviral activity of dipyridamole derivatives.
Among 46 novel pyrimido [5.4-d] pyrimidine derivatives, 26 compounds were found to exhibit antiviral activity as revealed in a test programme against Mengo, Coxsackie B1, fowl plague, vaccinia and pseudorabies viruses, as concerns inhibition of plaque formation and of infectious virus yield. Attempts to disclose structure-activity relationships by discriminant analysis pointed to a possible importance of hydrophobic substitution for the antiviral effectiveness against Mengo virus of the derivatives investigated.
D000998:Antiviral Agents; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D004176:Dipyridamole / Q000031:analogs & derivatives* / Q000494:pharmacology; D029822:Enterovirus B, Human / Q000187:drug effects; D011558:Herpesvirus 1, Suid / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D008574:Mengovirus / Q000187:drug effects; D009522:Newcastle disease virus / Q000187:drug effects; D014616:Vaccinia virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004176:Dipyridamole