Prevention of kernicterus, based on recent progress in bilirubin chemistry.
A review is presented of recent progress in bilirubin chemistry, its binding to albumin, displacement by drugs, and the mechanism of phototherapy. Quantitative formulations of the effect of albumin dosage, of varying pH, and of fatty acids result in a diagram which may be tried as an aid to indications for therapy.
D000418:Albumins / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001663:Bilirubin / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D003287:Contrast Media / Q000009:adverse effects; D005227:Fatty Acids / Q000494:pharmacology; D006728:Hormones / Q000009:adverse effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007647:Kernicterus / Q000517:prevention & control*; D012709:Serum Albumin; D013449:Sulfonamides / Q000009:adverse effects
D000418:Albumins; D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D003287:Contrast Media; D005227:Fatty Acids; D006728:Hormones; D012709:Serum Albumin; D013449:Sulfonamides; D001663:Bilirubin