Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man.
Intravenous administration of cimetidine, a histamine (H2) receptor antagonist, provoked an immediate 2 to 3-fold rise in serum prolactin concentrations in 8 normal men; serum thyrotropin, growth hormone, thyroxine, and triiodothyronine were not significantly affected. Diphenhydramine, an H1-antagonist, was without effect on any of the hormones measured. The results suggest that histamine may have an important function in the regulation of prolactin secretion in man.
D000328:Adult; D000368:Aged; D004155:Diphenhydramine; D013006:Growth Hormone / Q000097:blood; D006146:Guanidines; D006635:Histamine H2 Antagonists; D006801:Humans; D007093:Imidazoles; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D014284:Triiodothyronine; D004155:Diphenhydramine; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine