Comparative studies of parasympatholytic drugs on stomach (double blind test) and analysis of relation between gastric form and tonus.
Effects of 3 kinds of parasympatholytic drugs (timepidiumbromide, hyoscine-N-butylbromide and prifinium-bromide) and placebo (physiological saline solution) on the gastrointestinal tract were evaluated roentgenographically by double blind technique in a total of 101 male human subjects. The results may briefly be summarized as follows: 1. There were significant differences on hypotonic rate being one of the indexes of the gastric tonus between timepidium-bromide and placebo. The effects of 3 experimental drugs were significantly high as compared with that of placebo on peristaltic movement of the stomach. The effect of timepidium-bromide was significantly different from that of placebo on the site of arrival of barium. 2. The comparison of degrees of the gastric tonus between main and control tests revealed that the effect of placebo obtained in the main test was significantly inferior to that of hyoscine-N-butylbromide obtained in the control test, whereas there existed no significant differences of the effects among 3 active drugs. 3. Effects of each drug on the gastric tonus which was scored by hypertonic, normotonic and hypotonic state were evaluated by stratification. The result showed that the effect of timepidium-bromide was significantly greater than that of placebo. 4. All active drugs were not significantly different in terms of 7 observed values each on the gastric form.
D000268:Adhesiveness; D000328:Adult; D000368:Aged; D001466:Barium Sulfate; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D002986:Clinical Trials as Topic; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D011859:Radiography; D013269:Stochastic Processes; D013270:Stomach / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D013876:Thiophenes / Q000494:pharmacology
D010276:Parasympatholytics; D010880:Piperidines; D011759:Pyrrolidines; D013876:Thiophenes; D001466:Barium Sulfate; D002086:Butylscopolammonium Bromide