Some physicochemical properties of hemoglobin-manitoba (alpha2 102Ser replaced by Arg (G9) beta2).
Hb-Manitoba was discovered in 1970 [1] in a Canadian family of British origin. Recently we observed the same variant in a second family, and found that the oxy-derivative of Hb-Manitoba is slightly unstable at 65 degrees C, dissociates less readily at alkaline pH than does Hb-A, and forms asymmetric hybrids with other hemoglobins which are readily detectable by electrophoresis.
D000328:Adult; D001120:Arginine; D004592:Electrophoresis, Starch Gel; D005260:Female; D014644:Genetic Variation; D006455:Hemoglobins, Abnormal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008350:Manitoba; D010108:Oxyhemoglobins / Q000032:analysis; D012694:Serine; D013696:Temperature
D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; D012694:Serine; D001120:Arginine