[Comparative characteristics of fluorasizine metabolism in different species of animals and man].
The process of phthoracizine (10-(beta-diethylaminopropiniol)-2-triphthormethylphenothiazine hydrochloride) transformation proceeding in various animal species and in man is similar in grosso modo to biotransformation of chlorpromazine and of compounds related to the latter, including sulphoxidation, dealkylation in the side chain nitrogen, hydroxylation, glucoronoconjugation and the formation of products with the side chain degradation. At the same time, one can note a difference which finds its expression in the development of a large quantity of the phthoracizine metabolites attended by destruction of the side chain, as well as of hydroxylated sulphoxidated products of its transformation. In rats, more than in rabbits and mice, the spectrum of the phthoracizine metabolites is closer to the products of its biotransformation passed with the human urine.
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism* / Q000652:urine; D002855:Chromatography, Thin Layer; D002940:Circadian Rhythm; D005965:Glucuronates / Q000652:urine; D006801:Humans; D006900:Hydroxylation; D008297:Male; D051379:Mice; D010640:Phenothiazines; D011817:Rabbits; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D014150:Antipsychotic Agents; D005965:Glucuronates; D010640:Phenothiazines
Sravnitel'naia kharakteristika metabolizma ftoratsizina u razlichnykh vidov zhivotnykh i cheloveka