Evaluation of anxiolytic and amnesic effects of intramuscular lorazepam as a pre-operative medication.
In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lorazepam produced superior preoperative and post-operative anterograde amnesia, with respect to both incidence and duration. There was no difference in the pre-operative anxiolytic and soporofic effects of the two regimens and post-operatively, analgesic requirements and the incidence of vomitting and restlessness were the same in both groups of patients.
D000328:Adult; D000647:Amnesia / Q000139:chemically induced*; D014151:Anti-Anxiety Agents / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008140:Lorazepam / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D011300:Preoperative Care
D014151:Anti-Anxiety Agents; D008140:Lorazepam