Effects of graded infusions of monomethylmethacrylate on coagulation, blood lipids, respiration and circulation. An experimental study in dogs.
In 4 dogs injected intravenously (i.v.) with 125I labeled fibrinogen, 51Cr labeled platelets and 99mTc labeled albumin, and subjected to successively increasing amounts of i.v. infused monomethylmethacrylate, doses corresponding to the amounts released into the blood stream following implantation of acrylic cement during total hip replacements did not affect the clotting mechanism, did not cause trapping of platelets and fibrin in the lungs, did not generate fat emboli, and did not cause depression of the arterial oxygen tension or blood pressure. Monomethylmethacrylate in whole blood was associated with both blood cells and plasma.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001843:Bone Cements / Q000494:pharmacology*; D003097:Collateral Circulation / Q000187:drug effects*; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral; D008055:Lipids / Q000097:blood*; D008168:Lung / Q000187:drug effects; D008768:Methylmethacrylates / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
D001843:Bone Cements; D008055:Lipids; D008768:Methylmethacrylates