alpha-Naphthoflavone activation of 6-hydroxymethylbenzo(alpha)pyrene synthetase.
alpha-Naphthoflavone activates the aryl hydroxymethyl synthetase of both the microsomal membrane-bound and soluble enzymes of rat liver and rat lung. The enzyme catalyzes the hydroxymethylation of benzo(alpha)pyrene to the 6-hydroxymethyl derivative.
D000818:Animals; D001571:Benzoflavones; D001580:Benzopyrenes; D004789:Enzyme Activation; D005419:Flavonoids / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D019877:Hydroxymethyl and Formyl Transferases; D008168:Lung / Q000648:ultrastructure; D008566:Membranes / Q000378:metabolism; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D014166:Transferases / Q000378:metabolism*
D001571:Benzoflavones; D001580:Benzopyrenes; D005419:Flavonoids; C011512:alpha-naphthoflavone; D014166:Transferases; C021407:6-hydroxymethylbenzo(alpha)pyrene synthetase; D019877:Hydroxymethyl and Formyl Transferases