Effects of oxazolam, cloxazolam, and CS-386, new anti-anxiety drugs, on socially induced suppression and aggression in pairs of monkeys.
This experiment was conducted to examine effects of oxazolam, cloxazolam, CS-386, and reference drugs on socially induced suppression and aggression in pairs of monkeys. Oxazolam, cloxazolam, and CS-386, as well as other benzodiazepines, at both ataxic and non-ataxic doses, attenuated the socially induced suppression, but failed to show inhibitory effect on the on the socially induced aggression. Chlorpromazine, at both slight-sedative and non-sedative doses, reduced neither socially induced suppression nor aggression. Imipramine did not produce any significant effect in this study.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D003220:Conflict, Psychological; D000882:Haplorhini; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D012919:Social Behavior
D014151:Anti-Anxiety Agents; D010080:Oxazoles; D001569:Benzodiazepines; C000425:oxazolam; C005522:cloxazolam; C014262:mexazolam