Some evidence for aldosterone action on 2,3-diphosphoglycerate level in human red cells.
In healthy male subjects aldosterone excretion and plasma renin activity were reduced by a 4-6 hr head-out immersion in thermoindifferent water baths (35.5 +/- 0.1 degrees C). The red cell 2,3-diphosphoglycerate (DPG) concentration before and throughout immersion period was positively correlated both with aldosterone excretion in 2 hr pooled urine (r = +0.69; 2 p less than 0.001) and with renin activity (r = + 0.54; 2p less than 0.001) despite a concomitant increase of cubital venous pH and inorganic phosphate concentration. These findings furnish evidence for a regulatory role of aldosterone in DPG metabolism, possibily by a direct influence on red cell glycolysis.
D000328:Adult; D000450:Aldosterone / Q000652:urine*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007101:Immersion; D008297:Male; D010710:Phosphates / Q000097:blood; D012083:Renin / Q000097:blood
D004163:Diphosphoglyceric Acids; D010710:Phosphates; D000450:Aldosterone; D012083:Renin