[Effects of Alfatesine (ct 1341) on cerebral blood flow and metabolism in man. Global and regional changes].
The effects of Alfatesine on local cerebral blood flow  and on cerebral oxygen consumption were studied in 5 normal subjects and in 6 patients suffering from diffuse vascular repercussion of cerebral distress. There is a 75 p. 100 fall in cerebral  blood flow in the gray substance and a parallel fall in oxygen consumption. At rest, the caracteristic anaesthetic action modifies the caracteristical distribution of blood flows in the cortex. A relative hyperemia appears in the area of the central sulcus. Those focal changes could not be found in the group of pathogical patients.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000009:adverse effects / Q000494:pharmacology*; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D011277:Pregnanediones / Q000494:pharmacology*
D011277:Pregnanediones; D002245:Carbon Dioxide; D000530:Alfaxalone Alfadolone Mixture; D010100:Oxygen
Effets de l'alfantésine (CT 1341) sur le débit sanguin et le métabolisme cérébral chez l'homme modifications globales et régionales