Studies of maternal plasma prolactin and amniotic fluid prolactin. Effects of chlorpromazine and prostaglandin F2alpha.
We have studied the effect of chlorpromazine and PGF2alpha on the blood and amniotic fluid levels of prolactin over a 1-hour period of time in women who were in the 14th-20th week of gestation. Following intramuscular injection of chlorpromazine, maternal plasma prolactin rose 1.0- to 2.5-fold. No significant change was noted in maternal plasma after PGF2alpha administration. Amniotic fluid prolactin declined by 6 to 56%. These changes may be dilutional.
D000653:Amniotic Fluid / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011389:Prolactin Release-Inhibiting Factors / Q000037:antagonists & inhibitors; D011460:Prostaglandins F / Q000494:pharmacology*
D011460:Prostaglandins F; D011388:Prolactin; D011389:Prolactin Release-Inhibiting Factors; D002746:Chlorpromazine