Inhibition of gastric emptying and drug absorption by narcotic analgesics.
The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.
D000082:Acetaminophen / Q000378:metabolism; D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology*; D003864:Depression, Chemical; D005769:Gastrointestinal Motility / Q000187:drug effects*; D003932:Heroin / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013997:Time Factors
D000701:Analgesics, Opioid; D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D003932:Heroin; D008614:Meperidine