In vitro adsorption of doxorubicin hydrochloride on insoluble calcium phosphate.
The adsorption of doxorubicin hydrochloride, a potent antitumor agent, on solid tribasic calcium phosphate was studied in vitro. A Langmuir adsorption isotherm at pH 7.4 and the maximum adsorption capacity of tribasic calcium phosphate were established. Tribasic calcium phosphate was chosen as a model for solid bone samples, which are stained with doxorubicin in patients who have received long-term doxorubicin therapy.
D000327:Adsorption; D002130:Calcium Phosphates; D055598:Chemical Phenomena; D002621:Chemistry; D004317:Doxorubicin; D006863:Hydrogen-Ion Concentration; D013050:Spectrometry, Fluorescence
D002130:Calcium Phosphates; D004317:Doxorubicin