Studies concerning dopamine diuresis in the rat.
Dopamine is both diuretic and saluretic in the conscious rat. The diuretic effect does not appear to be beta-receptor mediated, but rather may be the result of a combination of alpha- and dopaminergic receptor stimulation. Conclusive proof for the existence of the latter, however, must await the discovery of a more selective peripheral dopamine-receptor stimulant than is dopamine per se.
D000818:Animals; D001060:Aporphines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002740:Chlorothiazide / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats
D001060:Aporphines; D010643:Phenoxybenzamine; D002740:Chlorothiazide; D005665:Furosemide; D007545:Isoproterenol; D004298:Dopamine; D009638:Norepinephrine