Bile canalicular alkaline phosphatase and disease.
The alkaline phosphatase reaction is normally absent in human bile canaliculi, but was found in 79 patients. In search for a common causal factor, these patients were further examined. Thirty-seven were autopsied. The conditions most ocmmonly associated with the phenomenon were malignant tumours with or without involvement of the liver, collagen diseases, long-standing partial obstruction of the common bile duct, and genetic variants of alpha-1-antitrypsin. No clinical or laboratory facts were common to all the patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D001798:Blood Proteins / Q000032:analysis; D003095:Collagen Diseases / Q000201:enzymology; D005260:Female; D042882:Gallstones / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology; D000637:Transaminases / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood
D001798:Blood Proteins; D007527:Isoenzymes; D000515:alpha 1-Antitrypsin; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D000469:Alkaline Phosphatase