Influence of alpha-adrenergic block and beta-adrenergic stimulation on distribution of cardiac output after cardiopulmonary bypass.
Organ and tissue damage restricts total cardiopulmonary bypass to a few hours in patients. The cause might be the disturbance of tissue flow in which the sympatho-adrenal hyper-activity plays a decisive role. In dogs, killed 30 min after cardiopulmonary bypass was stopped, we studied the tissue distribution of cardiac output with the method of Sapirstein. In one group the alpha-adrenergic blocker, in the other one the beta-adrenergic stimulator was continuously applied during the whole operation-period. Compared to a control group the per cent of cardiac output as well as the regional tissue flow after alpha-adrenergic block increased in the liver, ileum, adrenals, testes, kidney and in the skin and decreased in the spleen and thyroid gland. After beta-adrenergic stimulation the per cent of cardiac output increased in the heart muscle, lungs, liver, ileum, adrenals and m. soleus and decreased in the spleen and thyroid gland. The absolute values of organ tissue flow increased in ileum and decreased in the spleen, thyroid gland and in the kidney.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects*; D002315:Cardiopulmonary Bypass; D004285:Dogs; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists