The effects of p-chlorophenylalanine and ethanolamine-O-sulphate in an animal test of anxiety.
p-Chlorophenylalanine, which produces a depletion of brain 5-HT concentration, had effects qualitatively similar to those previously found with chronic chlordiazepoxide and with acute ethanol in the social interaction test of anxiety. This result is compatible with the idea that a reduced turnover of 5-HT is important in anxiety reduction. On the same test, ethanolamine-O-sulphate, which raises brain gamma-aminobutyric acid, was without effect, suggesting raised concentrations of this acid are not essential for anxiety reduction.
D000818:Animals; D001007:Anxiety / Q000378:metabolism / Q000523:psychology*; D001923:Brain Chemistry / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D010134:Fenclonine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012919:Social Behavior / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D004983:Ethanolamines; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D010134:Fenclonine