Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi.
beta-Lapachone, an antimicrobial agent, markedly increase the generation of H2O2 in intact Trypanosoma cruzi epimastigotes (Y strain). Increase in H2O2 was determined by the horseradish peroxidase-H2O2 Compound II formation as well as by a cytochemical technique.
D015100:3,3'-Diaminobenzidine / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000096:biosynthesis*; D014349:Trypanosoma cruzi / Q000378:metabolism* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D015100:3,3'-Diaminobenzidine; D006861:Hydrogen Peroxide