[Pharmacologic effect of protracted neuroleptics, fluphenazine oenanthate and oxyprothepine oenanthate (VUFB 9447)].
Two neuroleptica with protracted effect, i.e. Fluphenazin-Oenanthat and Oxyprothepin-Oenanthat, were tested on rats, dogs and rabbits. It was found that both drugs, after intramuscular injection in doses between 5--30 mg/kg, produced a long-lasting neuroleptic effect, in particular the inhibition of conditioned reflexes in rats, the antagonistic effect against apomorphine vomiting in dogs and the EEG-brain activity specific for neuroleptica. Hardly any differences were found between the effects of the two drugs. Both neuroleptica caused interesting spike activity in the EEG-registration particularly in the limbic structures which have hitherto not been described in the literature.
D000818:Animals; D001058:Apomorphine / Q000009:adverse effects; D003692:Delayed-Action Preparations; D003988:Dibenzothiepins / Q000494:pharmacology*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D004924:Escape Reaction / Q000187:drug effects; D005476:Fluphenazine / Q000494:pharmacology*; D008297:Male; D011600:Psychopharmacology; D011817:Rabbits; D051381:Rats; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control
D003692:Delayed-Action Preparations; D003988:Dibenzothiepins; D001058:Apomorphine; D005476:Fluphenazine
Die pharmakologische Wirkung der protrahierten Neuroleptika, Fluphenazin-Oenanthat und Oxyprothepin-Oenanthat (VUFB 9447).