[Experimental study of conjugates of a catabolite common to halothane, enflurane and fluroxene in guinea pigs].
The authors sensitized guinea pigs to a halothane catabolite, trifluoroacetic acid, combined with guinea pig albumin. They then exposed the animals to halothane. There was no correlation between the presence of humoral and cell-mediated immune reactions obtained with the catabolite and the incidence of liver necrosis.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004737:Enflurane / Q000276:immunology / Q000378:metabolism*; D004987:Ethers / Q000276:immunology / Q000378:metabolism*; D006168:Guinea Pigs; D006221:Halothane / Q000276:immunology / Q000378:metabolism*; D007111:Immunity, Cellular; D007114:Immunization; D008297:Male; D008738:Methyl Ethers / Q000378:metabolism*
D000906:Antibodies; D004987:Ethers; D008738:Methyl Ethers; D004737:Enflurane; D006221:Halothane
Etude expérimentale des conjugués d'un catabolite commun à l'halothane, enflurane et fluroxène chez le cobaye