Possible association of schizophrenia with a disturbance in prostaglandin metabolism: a physiological hypothesis.
Schizophrenia may be associated with increased prostaglandin synthesis in certain parts of the brain. This hypothesis is based on the following findings: (1) Catalepsy, which is the nearest equivalent in animals to human catatonia, develops in cats when prostaglandin E1 is injected into the cerebral ventricles and when during endotoxin or lipid A fever the prostaglandin E2 level in cisternal c.s.f. rises to high levels; however, when fever and prostaglandin level are brought down by non-steroid anti-pyretics which inhibit prostaglandin synthesis, catalepsy disappears as well. (2) Febrile episodes are a genuine syndrome of schizophrenia.
D000818:Animals; D001060:Aporphines / Q000009:adverse effects; D001921:Brain / Q000378:metabolism; D002375:Catalepsy / Q000134:cerebrospinal fluid / Q000139:chemically induced / Q000378:metabolism; D003490:Cyanosis / Q000150:complications; D005334:Fever / Q000134:cerebrospinal fluid / Q000150:complications; D006801:Humans; D007531:Isoflurophate / Q000009:adverse effects; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011458:Prostaglandins E / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*
D001060:Aporphines; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D007531:Isoflurophate