Tricyclic antidepressant drugs block histamine H2 receptor in brain.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects; D006635:Histamine H2 Antagonists; D009638:Norepinephrine / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism
D000929:Antidepressive Agents, Tricyclic; D006635:Histamine H2 Antagonists; D011976:Receptors, Muscarinic; D012701:Serotonin; D000262:Adenylyl Cyclases; D009638:Norepinephrine