[Structure of bromine containing metabolites of carbromal (author's transl)].
Isolation of three bromine containing metabolites from human urine is described and their chemical structure is proved by comparison of their physical properties with those of synthetically prepared substances. 2-Bromo-2-ethyl-butyramide, a pharmacologically active product, is showed to be the most important bromine containing metabolite by volume. In 3-position hydroxylated metabolites of carbromal, 3-hydroxy-carbromal and 2-Bromo-2-ethyl-3-hydroxy-butyramide have same physical properties as the synthesized DL-threo--diastereomeres.
D001966:Bromine / Q000652:urine; D006801:Humans; D006900:Hydroxylation; D008968:Molecular Conformation; D013057:Spectrum Analysis; D013237:Stereoisomerism; D014508:Urea / Q000652:urine*
D014508:Urea; D001966:Bromine
Strukturnachweis von bromhaltigen Carbromalmetaboliten