Effect of hypnotic and anxiolytic agents on regional concentration of acetylcholine in rat brain.
Pentobarbital (30 and 60 mg/kg) and chloral hydrate (300 and 600 mg/kg) administered in anesthetic/hypnotic doses produced significant increases in acetylcholine concentration in the cerebral cortex, striatum, hippocampus and brainstem. Hypnotic/anxiolytic agents like diazepam, flurazepam (100 mg/kg each) and triazolam (30 mg/kg) significantly increased the acetylcholine concentration only in the cerebral cortex and striatum. Alprazolam and ketazolam had no significant effect on regional distribution of acetylcholine in the brain. The results have been discussed with respect to the role of central cholinergic system in anesthetic and hypnotic actions of these drugs.
D000109:Acetylcholine / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000032:analysis / Q000187:drug effects; D002540:Cerebral Cortex / Q000032:analysis / Q000187:drug effects; D002697:Chloral Hydrate / Q000494:pharmacology; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects; D003864:Depression, Chemical; D006624:Hippocampus / Q000032:analysis / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D002697:Chloral Hydrate; D008620:Meprobamate; D010424:Pentobarbital; D000109:Acetylcholine