Interaction of local anesthetics with the transport system of glucose in human erythrocytes.
Local anesthetics inhibit the exhange transport of glucose in human erythroytes. All compounds tested showed a competitive inhibition except lidocaine and baycaine causing a non-competitive one. Moreover the transport system can bind two inhibitor molecules to one transport site as described for tetracaine and oxybuprocaine.
D000779:Anesthetics, Local / Q000378:metabolism / Q000494:pharmacology*; D001667:Binding, Competitive; D001693:Biological Transport, Active / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008012:Lidocaine / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D013748:Tetracaine / Q000378:metabolism / Q000494:pharmacology
D000779:Anesthetics, Local; D013748:Tetracaine; D011343:Procaine; D008012:Lidocaine; D005947:Glucose