Determination of hyoscyamine in BPC mixtures.
The hyoscyamine contents of four BPC mixtures (containing either belladonna or hyoscyamus tincture) were determined using the acid-dye technique. A sample size of 10 ml was required. The mean percentage recovery of hyoscyamine ranged from 99.73 to 101.03 from three mixtures; from the magnesium trisilicate and belladonna mixture, it was 94.8. The effects of pH and adsorption on the extraction of the alkaloid-dye complex from the mixtures examined are discussed.
D000536:Aluminum Hydroxide; D001285:Atropine / Q000032:analysis*; D001533:Belladonna Alkaloids; D002951:Citrates; D004338:Drug Combinations / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D008274:Magnesium; D013696:Temperature; D013997:Time Factors
D001533:Belladonna Alkaloids; D002951:Citrates; D004338:Drug Combinations; D000536:Aluminum Hydroxide; D001285:Atropine; D008274:Magnesium