[In vitro studies on parsalmide / bioavailability and protein binding (author's transl)].
The values of the diffusion constants at the different pH-values obtained using Stricker's apparatus, demonstrate that 2-propargyloxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 46-1) is characterized by a good absorption rate at gastric level and by a high absorption rate in the intestinal tract. The per cent of parsalmide bound to serum proteins, mainly to serum albumin, decreases with increasing concentration of parsalmide. Human serum binds about 55--70%, whereas bovine and equine serum bind about 40--60% of parsalmide at the different concentrations tested. The binding between parsalmide and serum proteins is a weak one: bound parsalmide is therefore set free very easily.
D000818:Animals; D001549:Benzamides / Q000378:metabolism* / Q000494:pharmacology; D001682:Biological Availability; D001702:Biopharmaceutics; D002417:Cattle; D005750:Gastric Juice / Q000378:metabolism; D006736:Horses; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects
D001549:Benzamides
In-vitro-Untersuchungen über Parsalmid. Verfügbarkeit und Eiweissbindung.