Intramuscular lorazepam versus pentobarbital premedication: a comparison of patient sedation, anxiolysis, and recall.
In a double-blind, controlled study in 40 veterans, IM lorazepam was significantly superior to IM pentobarbital as a preoperative sedative and in ability to suppress the memory of events of the operative day. A trend was noted (not statistically in this small series) toward greater patient acceptance of lorazepam. No important adverse effects or changes in vital signs occurred with either agent.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008140:Lorazepam / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D011229:Preanesthetic Medication; D013514:Surgical Procedures, Operative
D014151:Anti-Anxiety Agents; D010424:Pentobarbital; D008140:Lorazepam