[Comparative affinity of several standard anti-secretory agents for the intestinal cholinergic receptors of of rats and dogs].
Anticholinergic potentialities of four standard anti-secretory drugs (N-methyl-scopolammonium methylsulfate, atropine, diphemanil and prifinium) have been investigated with the help of molecular pharmacology techniques. The results gained with two different agonists (acetylcholine and carbachol) on rat and dog intestinal cholinergic receptors-jejunum and duodenum respectively-show : 1) That relative potentialities of the anticholinergic drugs (pA2) as well as those of the cholinomimetic agonists (pD2) are markedly modified according to which effector is used. 2) The N-methyl scopolammonium methylsulfate remains in any event the most potent anticholinergic drug investigated.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000378:metabolism; D001667:Binding, Competitive; D002217:Carbachol / Q000378:metabolism; D004285:Dogs; D007421:Intestine, Small / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010276:Parasympatholytics / Q000378:metabolism*; D011759:Pyrrolidines / Q000378:metabolism; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D012602:Scopolamine Derivatives / Q000378:metabolism
D010276:Parasympatholytics; D011759:Pyrrolidines; D011950:Receptors, Cholinergic; D012602:Scopolamine Derivatives; D001285:Atropine; D002217:Carbachol; D000109:Acetylcholine
Affinités comparées de quelques anti-sécrétoires de référence pour les récepteurs cholinergiques intestinaux du rat et du chien.