[Neurophysiologic justification of the place of neuroleptics in neuroleptanalgesia].
We studied the action of drugs on the cortical and systemic hemodynamic responses to reticular stimulation and somatic nociceptive stimulation. Central analgesics, even in high dosage, do not suppress the awakening reaction and the attack of hypertension produced by sciatic stimulation in curarised cats. The addition of a neuroplegic, such as Droperidol or Ethrane in low dosage, abolishes completely the response to painful stimulation. The action of pure analgesic anesthesia seems to be situated, above all, at spinal level.
D000701:Analgesics, Opioid / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004569:Electroencephalography; D006439:Hemodynamics / Q000187:drug effects; D009458:Neuroleptanalgesia; D011680:Pupil / Q000187:drug effects; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology; D014149:Tranquilizing Agents / Q000494:pharmacology / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D000777:Anesthetics; D014149:Tranquilizing Agents
Justification neurophysiologique de la place des neuroleptiques en neuroleptanalgésie