Action of beta-adrenergic blocking agents on the urethral pressure profile.
The action of beta-adrenergic blocking agents on the urethral pressure profile was studied. Sotalol, 20 mg, and inderal, 7 mg, were administered intravenously. Whereas the alpha-adrenergic blocking drug phentolamine, as already known, changed the maximum value of the pressure profile with an average decrease of 33%, the beta-adrenergic blocking drugs did not show any action at all. There was no difference between the results obtained with Sotalol and Inderal.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010646:Phentolamine / Q000494:pharmacology; D011312:Pressure; D011433:Propranolol / Q000494:pharmacology; D013015:Sotalol / Q000494:pharmacology; D014521:Urethra / Q000187:drug effects / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D013015:Sotalol; D010646:Phentolamine