[Pharmacologic study of clofelin].
Clofelin--2-(2,6-dichlorphenylamino)-2-imidasoline, an analoque of foreign-made clonidine (St155, catapresan, hemiton, etc) was subjected to a pharmacological study. In animals the drug produces first a rise and then protracted fall of the arterial pressure, reduces the frequency of cardiac contractions, lessens reflex hypertension that develops on compression of carotid arteries. When used in low doses it depresses the motor activity in unanesthetized animals and produces symptoms that bear evidence to its adrenomimetic action, e.g. exophthalmos, piloerection. Hypertension provoked by clofelin is caused by its peripheral and hypotension--by the central alpha-adrenomimetic action. The results of the present investigation prove clofelin to be identical with corresponding foreign drugs.
D000316:Adrenergic alpha-Agonists; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D000316:Adrenergic alpha-Agonists; D003000:Clonidine
Farmakologicheskoe issledovanie klofelina.