Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound.
Oxatomide or R 35443, 1-(3-[4-(diphenylmethyl)-1-piperazinyl]propyl)-1,3-dihydro--2H-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal arteries of the rat. In vivo it is a powerful antagonist of bronchospasm induced by serotonin and by histamine; it has no anticholinergic effects and does not affect blood pressure in spontaneously hypertensive rats. These antiserotonin properties of oxatomide may contribute significantly to its anti-allergic activity.
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists; D066298:In Vitro Techniques; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D012702:Serotonin Antagonists; D013997:Time Factors
D006634:Histamine H1 Antagonists; D008688:Methacholine Compounds; D010879:Piperazines; D012702:Serotonin Antagonists