[Relationship between the incidence of neurologic complications following smallpox vaccination and the generation and infectious activity of vaccine from strain L-IVP].
A strictly controlled epidemiological trial was applied to the study of the incidence of neurological complications in children inoculated with vaccine from the L-IVP strain of the 2nd, 3rd, and 5th passages (generations). To ascertain a possible connection between the neuropathogenicity with the infectious activity the persons vaccinated were divided into 3 groups in accordance with the infectiousness level of the preparation obtained: the I group--3--5-10(8)OOU/ml; the II group--6--8-9-10(8) OOU/ml; the III group over 9-10(8) OOU/ml. The least number of neurological complications was recorded among children primarily inoculated with the vaccine of the 3rd passage with the infectiousness titre of over 9-10(8) OOU/ml.
D002648:Child; D004673:Encephalomyelitis, Acute Disseminated / Q000209:etiology*; D006801:Humans; D012900:Smallpox Vaccine / Q000009:adverse effects*; D012901:Variola virus / Q000472:pathogenicity; D014774:Virulence
D012900:Smallpox Vaccine
Zavisimost' chastoty nevrologicheskikh oslozhneniĭ pri vaktsinatsii protiv ospy ot generatsii i infektsionnoĭ aktivnosti vaktsiny iz shtamma L-IVP.