The in vitro adsorption of drugs from horse serum onto carbon coated with an acrylic hydrogel.
In vitro studies have shown that uncoated carbon and carbon coated with an acrylic hydrogel are capable of adsorbing drugs from horse serum at 37 degrees. Increase in the coating weight from 2 to 4% decreased the rate of adsorption but not the total capacity. In vivo data supports the concept of carbon haemoperfusion for use in the treatment of drug overdose.
D000179:Acrylates; D000327:Adsorption; D000818:Animals; D002244:Carbon; D005782:Gels; D006736:Horses; D066298:In Vitro Techniques; D010477:Perfusion; D004364:Pharmaceutical Preparations / Q000097:blood*; D011041:Poisoning / Q000628:therapy; D011817:Rabbits; D013997:Time Factors
D000179:Acrylates; D005782:Gels; D004364:Pharmaceutical Preparations; D002244:Carbon