Localized scleroderma-like lesions after bone marrow transplantation in man. A chronic graft versus host reaction.
Localized scleroderma-like skin lesions which developed in two children, from 8 to 10 months after successful bone marrow transplantation for aplastic anaemia, showed histopathological features resembling those of scleroderma. This finding, like the animal models described in the literature, provides additional support for the auto-immune nature of scleroderma.
D000741:Anemia, Aplastic / Q000628:therapy; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D006087:Graft vs Host Reaction; D006801:Humans; D007109:Immunity; D008297:Male; D012594:Scleroderma, Localized / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014184:Transplantation, Homologous