The effect of allyl compounds on hepatic microsomal mixed function oxidation and porphyrogenesis.
The activities of 5-aminolaevulinate (5-ALA) synthetase and of various microsomat drug-metabolising enzymes have been determined in the livers of rats pretreated with different drugs and chemicals containing the allyl group. Safrole, isosafrole and secobarbital gave rise to slight increases in 5-ALA synthetase, whereas alclophenac and triallyl cyanurate almost doubled the enzyme activity and the known porphyrogenic agents, allylisopropylacetamide (AIA) and allobarbital caused increases of 1.5- and 2.5-fold, respectively. Allobarbital induced the microsomal drug-metabolising enzymes while secobarbital had only a weak effect and alclophenac and triallyl cyanurate had no effect at all. From these results it is suggested that induction of the synthesis of cytochrome P-450 is not rate dependent on the synthesis haem and induction of porphyrin biosynthesis.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000498:Allyl Compounds / Q000494:pharmacology*; D000502:Allylisopropylacetamide / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011166:Porphyrins / Q000096:biosynthesis*; D051381:Rats; D012451:Safrole / Q000494:pharmacology; D012631:Secobarbital / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000498:Allyl Compounds; D001463:Barbiturates; D011166:Porphyrins; D012631:Secobarbital; D000502:Allylisopropylacetamide; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D005037:Ethylmorphine-N-Demethylase; D000624:5-Aminolevulinate Synthetase; D012451:Safrole