[The influence of neuroleptic drugs on urinary excretion of non-protein nitrogen (author's transl)].
During treatment with thioxanthenes or phenothiazines of schizophrenic patients non-protein nitrogen in urine was measured. The values were calculated in relation to the excretion of creatinine. a) Flupentixol or fluphenazine applied in optimal dosage, increased the excretion of urea and the amino acids asp, glu + gln, and gly. b) Moreover, if the drug induced a parkinsonoid (thioridazine) the excretion of ser and thr was increased, too. The usual desalting procedure by ion-exchanging resins before chromatography increases the contents of several amino acids, e.g. asp, asn, ala, gly, cys, ser, thr, indicating a breakdown of some instable products.
D000596:Amino Acids / Q000652:urine; D003006:Clopenthixol / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D003404:Creatinine / Q000652:urine; D003692:Delayed-Action Preparations; D005475:Flupenthixol / Q000494:pharmacology; D005476:Fluphenazine / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins; D009584:Nitrogen / Q000652:urine*; D011352:Procyclidine / Q000494:pharmacology; D012559:Schizophrenia / Q000652:urine; D013881:Thioridazine / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014508:Urea / Q000652:urine
D000596:Amino Acids; D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins; D014149:Tranquilizing Agents; D014508:Urea; D003006:Clopenthixol; D003404:Creatinine; D011352:Procyclidine; D005475:Flupenthixol; D003024:Clozapine; D013881:Thioridazine; D009584:Nitrogen; D005476:Fluphenazine
Der Einfluss von Neuroleptika auf die Ausscheidung von Reststickstoffsubstanzen im Harn