Mice bearing the ob/ob mutation have impaired immunity.
The obese mutant mouse C57BL/6J ob/ob showed impaired ability to reject skin grafts or react to a contact-sensitising agent in comparison with littermate controls (either +/ob or +/+). Ability of spleen cells from mice bearing the ob/ob mutation to produce a graft-versus-host reaction in C57BL/6J X DBA/2J F1 hybrid mice was not impaired.
D000818:Animals; D003877:Dermatitis, Contact; D005260:Female; D006085:Graft Survival; D006087:Graft vs Host Reaction; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008954:Models, Biological; D016038:Skin Transplantation; D014184:Transplantation, Homologous