Endogenous opiates-a progress report.
The "opiate receptor" has become a  well-accepted entity, stimulating the search for an endogenous agonist. This has successfully revealed several different endogenous peptide opiates whose physiological role is under intense investigation, contributing to our understanding of pain and of opiate tolerance and dependence. A review of the current literature is presented.
D000067956:Adenylyl Cyclase Inhibitors; D000595:Amino Acid Sequence; D000701:Analgesics, Opioid; D000818:Animals; D004723:Endorphins / Q000502:physiology; D004745:Enkephalins / Q000502:physiology; D006801:Humans; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis; D010146:Pain; D010455:Peptides / Q000302:isolation & purification; D010902:Pituitary Gland / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology; D011957:Receptors, Opioid
D000067956:Adenylyl Cyclase Inhibitors; D000701:Analgesics, Opioid; D004723:Endorphins; D004745:Enkephalins; D009842:Oligopeptides; D010455:Peptides; D011453:Prostaglandins; D011957:Receptors, Opioid; D009270:Naloxone