Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys.
Enzymatic histamine synthesis by renal glomeruli of the rat has been examined. Assays of the partially purified enzyme demonstrated a pH optimum of 6.2, a Michaelis-Menten constant of 2.4 X 10(-4) histidine, and lack of potentiation by benzene. These data thus indicate that renal glomeruli contain the histidine-specific histidine decarboxylase.
D000818:Animals; D001554:Benzene / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000378:metabolism*; D006632:Histamine / Q000096:biosynthesis*; D006640:Histidine Decarboxylase / Q000302:isolation & purification / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007678:Kidney Glomerulus / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D051381:Rats
D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase; D001554:Benzene