Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis.
It is proposed that the same diseases as those induced by the graft-versus-host reaction (GVHR) will arise in nonchimeric individuals, if structures of the major histocompatibility complex (MHC) on lymphocytes are altered, either by viral infection or by chemicals, in such a way that autologous T lymphocytes react against them as the react in the GVHR to semiallogeneic (F1) lymphocytes differing at the MHC. Diseases in which a GVHR-like pathogenesis is suspected will be discussed.
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D001666:Binding Sites, Antibody; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects; D007244:Infectious Mononucleosis / Q000276:immunology; D013262:Stevens-Johnson Syndrome / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology; D014615:Vaccinia / Q000276:immunology
D006649:Histocompatibility Antigens; D006827:Hydantoins