Indolizine derivativatives with biological activity III: 3-(3-Aminopropyl)-2-methylindolizine, 3-(3-Aminopropyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and their N -alkyl derivatives.
The syntheses and a preliminary pharmacological evaluation of some aminopropylindolizines and aminopropyltetrahydroindolizines are reported. All compounds showed anti-5-hydroxytryptamine, anti-histamine, and antiacetylcholine activities. Some also exhibited weak CNS activity.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis; D066298:In Vitro Techniques; D007212:Indolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011437:Propylamines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D012702:Serotonin Antagonists / Q000138:chemical synthesis; D014590:Uterine Contraction / Q000187:drug effects
D006634:Histamine H1 Antagonists; D007212:Indolizines; D011437:Propylamines; D012702:Serotonin Antagonists; D000109:Acetylcholine