Polymorphism of disopyramide.
Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol-1 is calculated for the system. Dissolution and plasma concentrations show no significant differences in bioavailability between the two polymorphs.
D001682:Biological Availability; D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004206:Disopyramide / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D007700:Kinetics; D008297:Male; D011725:Pyridines / Q000032:analysis*; D012995:Solubility; D014961:X-Ray Diffraction
D011725:Pyridines; D004206:Disopyramide