Neuropharmacology and aging.
This review has attempted to convey the idea that the current concepts of psychotropic drug actions are based largely around the monoamine transmitter systems. Several of the hypotheses which implicate abnormalities of these systems as factors involved in the aging brain are discussed. It is suggested that the current lack of specific geriatric psychotropic agents is in part a reflection of our ignorance of the neurochemical basis of the aging process.
D000109:Acetylcholine / Q000378:metabolism; D000375:Aging; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism; D002090:Butyrophenones / Q000494:pharmacology; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009420:Nervous System / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism; D010640:Phenothiazines; D012110:Reserpine / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D001679:Biogenic Amines; D002090:Butyrophenones; D008996:Monoamine Oxidase Inhibitors; D018377:Neurotransmitter Agents; D010640:Phenothiazines; D012110:Reserpine; D008995:Monoamine Oxidase; D000109:Acetylcholine