[Elimination of allogeneic inhibition of hematopoietic stem cells by treatment of the recipient mice with cyclophosphane].
The experiments demonstrated that pretreatment of lethally irradiated recipient (CBA X C57BL/6) F1hybrid mice with cyclophosphamide (200 mg/kg of body weight) on day before the bone marrow transplantation (4 hours after the irradiation) suppressed the allogeneic inhibition of hematopoietic stem cells to 24% (while the inhibition in the untreated animals was 92.5%). It is suggested that cyclophosphamide acted on the recipient's radioresistant lymphoid cells effecting the allogeneic inhibition of stem cells.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation; D051379:Mice; D014184:Transplantation, Homologous
D003520:Cyclophosphamide
Otmena allogennoĭ ingibitsii stvolovykh krovetvornykh kletok putem obrabotki mysheĭ-retsipientov tsiklofosfanom