Influence of "lytic cocktail" on blood flow and oxygen consumption in the rat brain.
The influence of a sedative dose of "lytic cocktail" (chlorpromazine, promethazine and pethidine) on cerebral blood flow (CBF) and oxygen consumjtion (CMRO2) was tested in artificially ventilated rats, maintained on either 70% N2 or 70% N2O. When given alone, the lytic cocktail had no significant effect on CBF or CMRO2. However, in the presence of nitrous oxide there was a 25% reduction in blood flow and oxygen consumption.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004338:Drug Combinations; D006863:Hydrogen-Ion Concentration; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D011398:Promethazine / Q000494:pharmacology*; D051381:Rats
D004338:Drug Combinations; D008614:Meperidine; D011398:Promethazine; D002746:Chlorpromazine