[Mechanism of the analgesic effect of narcotic analgetics].
A study was made of the effect of morphine, promedol, phentanyl, pentazacine and psychostimulant d,l-amphetamine on the threshold of pain sensitivity and self-stimulation of the hypothalamus and the septum in rats. Electrical stimulation of the systems of positive reinforcement of the hypothalamus and the septum, and also analgetics increased the threshold of pain sensitivity, whereas d,l-amphetamine failed to influence it. D,l-amphetamine and morphine facilitated, promedol failed to influence, phentanyl decreased and pentazacine completely depressed the hypothalamic self-stimulation. The septal self-stimulation remained unaltered under the effect of morphine, promedol, phentanyl, but was decreased under the effect of pentazacine and increased against the background of d,l-amphetamine. A conclusion was drawn that the analgetic action and that activating the positive emotion were independent effects of the psychotropic agents.
D000661:Amphetamine / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D005283:Fentanyl / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D010423:Pentazocine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects; D012688:Septum Pellucidum / Q000502:physiology
D000701:Analgesics, Opioid; D010880:Piperidines; D009020:Morphine; D000661:Amphetamine; D010423:Pentazocine; D005283:Fentanyl
K mekhanizmu boleutoliaiushchego deĭstviia narkoticheskikh anal'getikov