[Model of motion sickness in dogs for assessing the effectiveness of pharmacological substances].
The paper describes a model of motion sickness for dogs. The method is based on the simultaneous use of vertical and rotatory movement of the device with a continuously varying angular velocity of rotation to generate Coriolis acceleration. The exposure increases significantly the number of sick animals to be used in the selection of antimotion drugs. Diphenidol, marezine, tigane, bromotigane and metachloropromide were tested. Diphenidol and to a lesser extent marezine and metachloropromide proved effective. Tigane and bromotigane were ineffective against motion sickness.
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D003312:Coriolis Force; D003501:Cyclizine / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use; D009041:Motion Sickness / Q000188:drug therapy*; D010276:Parasympatholytics / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D013997:Time Factors
D000932:Antiemetics; D001549:Benzamides; D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D010880:Piperidines; D008787:Metoclopramide; C004858:diphenidol; D003501:Cyclizine
Model' bolezni ukachivaniia sobak dlia otsenki éffektivnosti farmakologicheskikh veshchestv.