Interactions of gastric blood flow, barrier breaker, and hydrogen ion back diffusion during ulcer formation in the rat.
A rat gastric chamber preparation was used to determine the interrelations between H+ back diffusion, mucosal blood flow, the area of mucosa treated with bile salts and ulcer formation. The rate of H+ back diffusion was found to be dependent on both mucosal blood flow and the area of mucosa exposed to bile salts. It is concluded that, although H+ back diffusion is a convenient measure of barrier permeability under conditions of normal mucosal blood flow, during mucosal ischemia this parameter fails to reflect permeability because of decreased mucosal clearance of H+. These findings would explain apparent controversy whereby ulceration occurs under shock conditions in the absence of apparent H+ back diffusion.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D004058:Diffusion; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008297:Male; D010539:Permeability; D051381:Rats; D013270:Stomach / Q000503:physiopathology; D013276:Stomach Ulcer / Q000503:physiopathology*; D013656:Taurocholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D013656:Taurocholic Acid