[The effect of thyroxine on the 2,3-diphosphoglycerate content of erythrocytes in vivo and in vitro].
After ending a continous treatment with thyroxine the average dropping of the 2,3 DPG level was 0.4 mumol/ml. T4 decreased on the average by 7.6 microgram/ml. One time application of 1 mg thyroxine p.o. led within 24 hours to an increase of the 2,3 DPG level of -chi = 0.2 mumol/ml, the pH in the erythrocytes increased by 0.02 on the average. Blood incubation with thyroxine added in a concentration of -chi = 24 microgram/100 ml showed no increase of 2,3 DPG, pH and phosphate, while there was a significant acidosis and increase of phosphate in the control blood. The lactate production was significantly lower and glucose consumption was significantly higher in the blood with thyroxine.
D001786:Blood Glucose; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007773:Lactates / Q000097:blood; D010710:Phosphates / Q000097:blood; D013974:Thyroxine / Q000494:pharmacology*
D001786:Blood Glucose; D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D007773:Lactates; D010710:Phosphates; D013974:Thyroxine
Der Einfluss von Thyroxin auf den 2,3-DPG-Gehalt der Erythrozyten in vivo und in vitro.