Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists.
The beta-adrenoceptor blockers propranolol, PhQA33 and LB-46 exhibited appreciable activity against tremorine-(TMN) and oxotremorine-(OTMN) induced tremor, whereas pronethalol, (+)-H56/28, (-)-H56/28, Kö-592 and L(+)-INPEA possessed weak action. The two beta-blockers, namely D,L(+/-)-INPEA and D(-)-INPEA acted as weak tremorgens. None of the above compounds suppressed the induced peripheral cholinergic phenomena; or possessed any central anticholinergic activity, as they were unable to afford protection against physostigmine-induced death. Propranolol, PhQA33 and LB-46 antagonized TMN-induced hypothermia and analgesia, but were inactive against OTMN-induced changes. A correlation of the beta-blocking and anti-tremor activity of these agents is unlikely.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003864:Depression, Chemical; D008297:Male; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology*; D010830:Physostigmine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D014202:Tremor / Q000139:chemically induced*; D014203:Tremorine / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D000700:Analgesics; D010095:Oxotremorine; D010830:Physostigmine; D014203:Tremorine