Direct resorption of bone by human monocytes.
Cultured human peripheral blood monocytes stimulate the release of bone mineral and matrix from killed long bones of fetal rats. These effects were inhibited by cortisol but were not altered by hormones that normally stimulate osteoclastic bone resorption. There was no evidence of morphologic differentiation of the monocytes into osteoclasts during bone resorption.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000502:physiology; D002116:Calcitonin / Q000494:pharmacology; D002448:Cell Adhesion; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008264:Macrophages / Q000502:physiology; D009000:Monocytes / Q000502:physiology*; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats
D004100:Dihydroxycholecalciferols; D010281:Parathyroid Hormone; D002116:Calcitonin; D006854:Hydrocortisone