[Effect of liver damage by thioacetamide on microsomal aromatization of testosterone in rats (author's transl)].
Rat liver microsomes, NADPH-regenerating system, and 1beta, 2beta-3H-testosterone have been incubated in vitro. The loss of tritium from the steroid, associated with aromatization of testosterone, was linear with time for 20 min and required NADPH. Pre-treatment of the rats with thioacetamide raised the liberation of tritium from 1beta, 2beta-3H-testosterone. The results suggest that liver damage by thioacetamide in rats may give rise to increased aromatization of testosterone.
D000081:Acetamides / Q000506:poisoning*; D000818:Animals; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D009249:NADP / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000378:metabolism*; D013853:Thioacetamide / Q000494:pharmacology / Q000506:poisoning*; D013997:Time Factors
D000081:Acetamides; D013853:Thioacetamide; D013739:Testosterone; D009249:NADP
Die Wirkung einer Leberschädigung durch Thioacetamid auf die mikrosomale Aromatisierung von Testosteron bei der Ratte