Thphenidate.
Plasma cyclic-AMP responses to adrenergic agonists are due to stimulation of the peripheral beta-adrenergic receptor. Mood responses to stimulants are thought to be due to actions leading to stimulation of central catecholamine receptors. To determine if a peripheral measure of receptor sensitivity could predict central mood effects of stimulants, the plasma cyclic-AMP response and the mood response to intravenous methylphenidate were determined simultaneously in 13 subjects. No correlation between the two responses was found.
D000275:Adjustment Disorders / Q000188:drug therapy; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D000242:Cyclic AMP / Q000097:blood*; D003863:Depression / Q000188:drug therapy; D004644:Emotions / Q000187:drug effects*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged
D000318:Adrenergic beta-Agonists; D008774:Methylphenidate; D000242:Cyclic AMP