Alpha-tocopherol: uses in preventing nitrosamine formation.
alpha-Tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-Tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. The use of alpha-tocopherol was shown to inhibit aminopyrene-nitrite induced hepatotoxicity in rats and to reduce the amount of NDMA formed in cigarette smoke. Of primary interest is the finding of a significant reduction of NPYR formation in fried bacon. Nitrosamine inhibition was greater with alpha-tocopherol used in combination with sodium ascorbate than with sodium ascorbate alone.
D000818:Animals; D001205:Ascorbic Acid; D055598:Chemical Phenomena; D002621:Chemistry; D006863:Hydrogen-Ion Concentration; D008460:Meat / Q000032:analysis; D009573:Nitrites; D009602:Nitrosamines / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D012907:Smoking / Q000378:metabolism; D013552:Swine; D014810:Vitamin E / Q000494:pharmacology*
D009573:Nitrites; D009602:Nitrosamines; D014810:Vitamin E; D001205:Ascorbic Acid