Muscular work and the release of prostaglandin-like substances.
Experimental evidence for the release of prostaglandin-like substances, mainly of the E type, into the venous outflow from working skeletal muscles in the dog is described. Muscular exercise of the hind-leg produced by sciatic nerve stimulation evoked the release of prostaglandin-like substances detected in femoral venous blood by the bioassay method. This release occurred during and after muscular work, was abolished by indomethacin, and was not present in gallamine-treated dogs. The results suggest that endogenous vasodilator prostaglandins released during and after muscular work may contribute to local hyperaemic response during and, mainly, after muscular activity.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D003106:Colon / Q000098:blood supply; D004285:Dogs; D004558:Electric Stimulation; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010477:Perfusion; D005082:Physical Exertion; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D012007:Rectum / Q000098:blood supply; D013270:Stomach / Q000098:blood supply
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D002245:Carbon Dioxide; D005703:Gallamine Triethiodide; D010100:Oxygen; D007213:Indomethacin