Synthesis, physicochemical parameters, and in vitro evaluation of N1-p-chlorophenyl-N5-alkylbiguanides.
A series of N1-p-chlorophenyl-N5-alkylbiguanides were synthesized as potential inhibitors of dental plaque. Partition coefficients and pKa values were determined by standard methods. Biological activity was evaluated against Streptococcus mutans, a pure strain of plaque-forming bacteria. All compounds were compared to chlorhexidine acetate.
D001645:Biguanides / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002710:Chlorhexidine / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D011199:Potentiometry; D012995:Solubility; D013295:Streptococcus mutans / Q000187:drug effects
D001645:Biguanides; D002710:Chlorhexidine