Use of protease inhibitor (trasylol) and heparin in cardiorespiratory resuscitation. II. Gasometric investigations of arterial blood.
The purpose of the present work was to assess the effect of trasylol--an inhibitor of proteases--and heparin on gasometric values in arterial blood during cardio-respiratory resuscitation. The investigations were carried out on rabbits in three experimental groups. In group I the simplest resuscitation procedures were applied: artificial respiration with AMBU self-expanding bag and heart massage. In group II oxygen was given for respiration, heart massage was applied, cardiac, vasoactive and alkalinizing drugs were given. Group III received the above drugs and procedures but trasylol and herparin were used additionally. Cardiac arrest was obtained by means of acute hypoxia following suxamethonium administration. The investigations showed that in groups I and II despite resuscitation management arterial hypoxaemia and metabolic acidosis persisted while in group III a certain return of normal gasometric values was observed and the animals in this group survived the experiment.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D001639:Bicarbonates / Q000097:blood; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011817:Rabbits; D012151:Resuscitation
D001639:Bicarbonates; D002245:Carbon Dioxide; D006493:Heparin; D007611:Aprotinin; D010100:Oxygen