Reduction in enamel dissolution by liquorice and glycyrrhizinic acid.
Liquorice extracts and confections reduced enamel dissolution in acidic buffers and saliva/glucose incubations by a direct effect on solubility, and by inhibiting the fall in pH on incubation. These actions may be attributed to the solubility-reducing, glycolysis-inhibiting, and buffering properties of glycyrrhizinic acid, a constituent of liquorice.
D002021:Buffers; D002327:Cariostatic Agents; D003743:Dental Enamel / Q000378:metabolism; D003747:Dental Enamel Solubility / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology; D005965:Glucuronates / Q000378:metabolism / Q000494:pharmacology*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D006035:Glycyrrhiza; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010946:Plants, Medicinal; D012463:Saliva / Q000502:physiology; D013395:Sucrose / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*
D002021:Buffers; D002327:Cariostatic Agents; D005965:Glucuronates; D014315:Triterpenes; D013395:Sucrose; D005947:Glucose; D006034:Glycyrrhetinic Acid