Evaluation of the local antihistaminic activity of dimetindene maleate by a quantitative method.
The topical application of a 0.1% dimetindene maleate gel on the forearms of 11 subjects reduces the areas of both erythema and wheal produced by the intradermal injection of 0.025 mg of histamine hydrochloride to a statistically greater degree than 1% d-chlorpheniramine maleate cream (p less than 0.005 and p less than 0.0005, respectively). The quantitative method employed in this study has proved to be an excellent means for the evaluation of the antihistaminic activity of topical preparations.
D000287:Administration, Topical; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004115:Dimethindene / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004890:Erythema / Q000188:drug therapy; D006634:Histamine H1 Antagonists; D006801:Humans; D014581:Urticaria / Q000188:drug therapy
D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine; D004115:Dimethindene