[Investigations about the effect of run-training and run-stress on glucose tolerance and insulin secretion with ageing streptozotocin-diabetic rats (author's transl)].
Untrained grown-up and old rats with a mild Streptozotocin-diabetes show in i.v. glucose tolerance test a pathological glucose assimilation and diminished insulin secretion in comparison to control rats of the same age after a maximal run-stress. Trained rats show a different behaviour in glucose tolerance test depending on their age and seriousness of diabetes: Glucose tolerance is improved in grown-up rats with a mild diabetes and unchanged in old rats. Six-week run-training causes a significant deterioration of glucose tolerance in rats with a medium seriously Streptozotocin-diabetes and even leads to death of old rats because of decompensated metabolism. Grown-up rats with a mild diabetes stand run-stress after run-training better than the old ones. No animal with a medium seriously diabetes survives maximal run-stress, old rats don't even survive the slowly increasing run-training. - These results confirm the dualistic effect of muscular work. Metabolism of mild diabetes becomes better through muscular exertion the one of medium diabetes gets worse. Therefore a good effect of run-training is measurable only in grown-up rats not in old ones.
D000367:Age Factors; D000375:Aging; D000818:Animals; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology*; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D005082:Physical Exertion; D051381:Rats; D012420:Running; D013311:Streptozocin
D007328:Insulin; D013311:Streptozocin
Untersuchungen zur altersabhängigen Wirkung von Lauftraining und Laufstress auf Glucosetoleranz und Insulinsekretion bei Streptozotocin-diabetischen Ratten.