Action of six commonly used benzodiazepines on isolated guinea-pig ileum preparation.
The spasmolytic activity of six commonly used benzodiazepines was investigated on isolated guinea-pig ileum preparation. All six substances proved to be non-competitive antagonists of carbachol and barium chloride, the pD'2 values ranging between 3.23 and 4.37 in the presence of either agonist. The significance of these findings is discussed.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001464:Barium / Q000037:antagonists & inhibitors; D001569:Benzodiazepines; D002217:Carbachol / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010208:Papaverine / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001464:Barium; D002217:Carbachol; D010208:Papaverine