Suppression and stimulation mechanisms controlling glucagon secretion in a case of islet-cell tumor producing glucagon, insulin, and gastrin.
The mechanisms controlling secretion of glucagon and other pancreatic hormones were studied in a patient affected with multihormone-secreting islet-cell tumor. Fasting glucagon levels (3,000 pg./ml.) rose to 10 ng./ml. following arginine stimulation. While oral glucose load and intravenous glucose infusion did not suppress glucagon secretion, insulin administration induced a prompt depression in glucagon levels. Glucagon, insulin, and gastrin levels were suppressed by somatostatin while calcium infusion caused a paradoxical increase. It is suggested that only some of the stimulation-inhibition mechanisms were conserved in this case of glucagon-secreting pancreatic tumor.
D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005755:Gastrins / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005755:Gastrins; D007328:Insulin; D013004:Somatostatin; D013006:Growth Hormone; D005934:Glucagon; D001120:Arginine; D005947:Glucose; D002118:Calcium