Plasma levels of clobazam after three oral dosage forms in health subjects.
As can be seen from the tables, the terminal half-life of clobazam is about 50 hours, and from a solid dosage form the peak plasma level occurs approximately 1.5 hours after ingestion. Thus, there is a significant, yet relatively short, dosage form delay effect when the solid dosage forms are compared to the rapidly available solution of the drug. However, based on the areas under the curve, comparison of the solid dosage forms with the solution indicates that the fraction of clobazam absorbed is 1. Pupil diameter measurement at 2, 4, and 6 hours after ingestion of clobazam correlated well with the plasma levels at these times. Pupils were constricted to the highest degree at 2 hours and approached the initial pupillary diameter at the 6-hour measurement.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000097:blood*; D001569:Benzodiazepines; D001682:Biological Availability; D002214:Capsules; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D012996:Solutions; D013607:Tablets; D013997:Time Factors
D014151:Anti-Anxiety Agents; D002214:Capsules; D012996:Solutions; D013607:Tablets; D001569:Benzodiazepines