The influence of serotonin on the mitotic rate in the colonic crypt epithelium and in colonic adenocarcinoma in rats.
1. The mitotic rate in the crypts of Lieberkühn of the descending colon and in dimethylhydrazine-induced adenocarcinomata of the descending colon of rat was measured using a stathmokinetic technique. 2. Intraperitoneal injection of a small dose (10 microgram/kg) of serotonin resulted in an increase in the tumour cell mitotic rate. 3. Blockade of serotonin receptors by 2-bromolysergic acid diethylamide and depletion of tissue serotonin levels following injection of DL-6-fluorotryptophan both result in a decrease in the tumour cell mitotic rate. 4. Treatment with serotonin, 2-bromolysergic acid diethylamide and DL-6-fluorotryptophan were all without effect on the colonic crypt cell mitotic rate.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D003106:Colon / Q000166:cytology*; D003110:Colonic Neoplasms / Q000473:pathology*; D004848:Epithelium / Q000187:drug effects; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014364:Tryptophan / Q000031:analogs & derivatives / Q000494:pharmacology
D012702:Serotonin Antagonists; D012701:Serotonin; D014364:Tryptophan; D008238:Lysergic Acid Diethylamide