Bone marrow colony-forming cells in acute drug-induced agranulocytosis.
The capacity to differentiate and form colonies in vitro by bone marrow granulocytic precursor cells and its evolution were studied in eight cases of drug-induced acute agranulocytosis. In three cases colonies and clusters count were normal or high. These cases were probably immunological agranulocytosis. In the five other cases this number was very low and returned to normal from three to thirteen days. These were probably cases of marrow suppression by the drug.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced / Q000473:pathology*; D002999:Clone Cells; D003114:Colony-Forming Units Assay; D004177:Dipyrone / Q000009:adverse effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006634:Histamine H1 Antagonists / Q000009:adverse effects; D006801:Humans; D007116:Immunization, Passive / Q000009:adverse effects; D007978:Levamisole / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
D006634:Histamine H1 Antagonists; D007978:Levamisole; D004177:Dipyrone