Blockade by burimamide of the restorative effect of histamine in tetrodotoxin-treated heart preparations.
1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2-4 x 10(-5) M), excitability was restored by histamine (6 x 10(-6) M to 10(-5) M). 2 This effect was antagonized by EDTA (2 X 10(-6) M),D600 compound (0.5mug/ml) and the H2-receptor antagonist, burimamide(2 X 10(-4) M).
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002049:Burimamide / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D005711:Gallopamil / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D013779:Tetrodotoxin / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives*
D006634:Histamine H1 Antagonists; D005711:Gallopamil; D013779:Tetrodotoxin; D006632:Histamine; D004492:Edetic Acid; D013890:Thiourea; D002049:Burimamide