Effect of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4.5-diphenyl-oxazolyl-(2)]-hydrazone (IMET 98/69) on lethal mengo virus encephalitis.
3-[Bis-(2-hydroxyethyl)-amino]-acetophenone-[4.5-diphenyl-oxazolyl-(2)]-hydrazone (IMET 98/69) was found to afford maximum "rates of protection" in intraperitoneally (i.p.) or intranasally (i.n.) induced Mengo virus encephalitis in mice when administered once daily at doses of 1 mmole/kg (456.5 mg/kg) subcutaneously (s.c.) or 4 mmoles/kg (1 826 mg/kg) perorally (p.o.). Three days of treatment were sufficient if started on the day before or at the time of virus inoculation. Initiation of treatment 6 hours after inoculation was no longer effective. In a remarkable number of brains from infected and treated mice no virus was detectable, while in the remaining brains the appearance of virus was strongly delayed, and its amount significantly reduced.
D000098:Acetophenones / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004660:Encephalitis / Q000517:prevention & control*; D004769:Enterovirus Infections / Q000517:prevention & control*; D007279:Injections, Subcutaneous; D008297:Male; D008574:Mengovirus / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D010080:Oxazoles / Q000008:administration & dosage / Q000627:therapeutic use
D000098:Acetophenones; D000998:Antiviral Agents; D010080:Oxazoles