[Studies on gamma-oryzanol. III. Influence of gamma-oryzanol on circadian rhythms of serum gastrin, 11-OHCS and gastric secretion in rats (author's transl)].
In the course of investigations of gamma-oryzanol in rats, circadian rhythms in antiulcerogenic action on gamma-oryzanol were observed. Circadian rhythms in several other parameters were investigated and correlated with the antiulcerogenic action. Pretreatment of rats with gamma-oryzanol 100 mg/kg, s.c., for 5 days tended to decrease serum gastrin levels and gastric secretion, and to increase serum 11-OHCS. Suppresive patterns of serum gastrin and gastric secretion following the pretreatment with gamma-oryzanol corresponded to the circadian rhythms in antiulcerogenic action of gamma-oryzanol. A complication of our results suggests that increment of catecholamines in rat brain after gamma-oryzanol plays a role in the above mentioned actions.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects*; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D008297:Male; D009526:Nialamide / Q000494:pharmacology; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D015062:11-Hydroxycorticosteroids; D005755:Gastrins; D010666:Phenylpropionates; D001285:Atropine; D012110:Reserpine; D009526:Nialamide