[Effect of contrast media on the rate of oxidation of NADP.H and NAD.H by rat liver microsomes].
The effect of roentgen-contrast media on the activity of the NADP'N and NAD'N-dependent electron-transport chains of the rats liver microsomes was studied. Bilignost, cardiotrast, triiotrast and triombrin are shown to lower the rate of the NADP'N oxidation by the rats' liver microsomes and have no effect (except for triiotrast) upon the rate of the NAD'N oxidation. It is presumed that the relative resistance of the NAD'N-specific flavoproteid is due to the presence of a hydrophobic layer impervious to the polar molecules of the contrast media.
D000100:Acetrizoic Acid / Q000494:pharmacology; D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology; D007458:Iodipamide / Q000494:pharmacology; D007468:Iodopyracet / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D003287:Contrast Media; D009243:NAD; D003973:Diatrizoate; D000100:Acetrizoic Acid; D009249:NADP; D007458:Iodipamide; D007468:Iodopyracet
Issledovanie deĭstviia rentgenokontrastnykh veshchestv na skorost' okisleniia NADF.H i NAD.H mikrosomami pecheni krys.