Cardiac and bronchial beta-adrenoceptor antagonistic potencies of atenolol, metoprolol, acebutolol, practolol, propranolol and pindolol in the anaesthetized dog.
1. The beta-adrenoceptor antagonists atenolol, metoprolol, acebutolol, practolol, propranolol and pindolol have been tested for their ability to reduce isoprenaline-induced bronchodilation and tachycardia in the anaesthetized dog. 2. Atenolol, metoprolol, acebutolol and practolol all possessed a similar degree of cardioselectivity in this animal model.
D000070:Acebutolol / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects* / Q000294:innervation; D004285:Dogs; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D000070:Acebutolol; D011433:Propranolol; D010869:Pindolol; D008790:Metoprolol; D007545:Isoproterenol; D011217:Practolol