Conversion of cefamandole nafate to cefamandole sodium.
The rate of hydrolysis of the formyl moiety of cefamandole nafate was determined as a function of pH, temperature, and concentration of added sodium carbonate or tromethamine. The reaction rate was sensitive to hydroxide ion in the pH 5.5-8.0 range with half-life values of hours to minutes. Hydrolysis was rapid upon the addition of sodium carbonate or tromethamine. Chirality in the 7-D-mandelamido side chain was unaffected by hydrolysis.
D002254:Carbonates; D002511:Cephalosporins; D055598:Chemical Phenomena; D002621:Chemistry; D004983:Ethanolamines; D005561:Formates; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D008333:Mandelic Acids; D013696:Temperature; D014325:Tromethamine
D002254:Carbonates; D002511:Cephalosporins; D004983:Ethanolamines; D005561:Formates; D008333:Mandelic Acids; D014325:Tromethamine