[Renal excretion of long term sulfonamides under fluid administration and modification of the urinary pH value].
The renal excretion of sulfaclomide, sulfamerazine and sulfamethoxypyridazine is delayed by increased fluid application in rats. The simultaneous administration of sulfonamides and ammonium chloride or sodium hydrogen carbonate causes, respectively, retardation and acceleration of renal sulfonamide excretion which is consistent with the change in urinary pH value. The retarded renal sulfonamide excretion with increasing diuresis is explained by the ensuing change in the urinary pH value. For clinical uses, a speedy renal excretion of long-time sulfonamides by increased diuresis can be expected only if alkalization of the urine is achieved at the same time.
D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013416:Sulfamerazine / Q000652:urine; D013421:Sulfamethoxypyridazine / Q000652:urine; D013449:Sulfonamides / Q000652:urine*; D014882:Water-Electrolyte Balance
D001639:Bicarbonates; D013449:Sulfonamides; D000643:Ammonium Chloride; D012964:Sodium; D013421:Sulfamethoxypyridazine; D013416:Sulfamerazine
Renale Ausscheidung von Langzeitsulfonamiden bei Flüssigkeitsbelastung und Anderung des pH-Wertes des Harns