[Effect of aminazin on the enzymatic oxidation of lipids].
An inhibitory effect of chlorpromazine on the enzymatic NADPH-dependent lipid peroxidation in rat liver microsomal fraction was found. This inhibition was caused by the 1) antioxidative effect of hydroxy-derivatives appearing during the oxidative metabolism of chlorpromazine with NADPH-dependent microsomal oxygenases, and by the 2) competition for reduced components of electron-carriers between the NADPH-dependent processes: chlorpromazine metabolism and lipids peroxidation.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009249:NADP; D010545:Peroxides / Q000096:biosynthesis*; D051381:Rats
D010545:Peroxides; D009249:NADP; D002746:Chlorpromazine
Vliianie aminazina na fermentativnoe okislenie lipidov.