Cyclic AMP and cyclic GMP in epidermal physiology and pathophysiology.
The second messengers cyclic AMP and cyclic GMP in several organs appear to coordinate those molecular events which are responsible for specialized organ function. As a result of balanced cell proliferation and specialization, epidermis functions by terminal specialization which provides a barrier between man and environment. Since the epidermal component of psoriasis is a classic example of deranged epidermal homeostasis, which has a low level of cyclic AMP and a high level of cyclic GMP, it seems reasonable that rebalancing these cyclic nucleotides might ultimately be a safe and effective therapy for psoriasis and other proliferative skin diseases.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D006152:Cyclic GMP / Q000378:metabolism / Q000502:physiology*; D006003:Glycogen / Q000378:metabolism; D006131:Growth Inhibitors / Q000502:physiology; D006162:Guanylate Cyclase / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008027:Light; D051379:Mice; D008938:Mitosis; D011494:Protein Kinases / Q000378:metabolism; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012867:Skin / Q000166:cytology* / Q000378:metabolism / Q000473:pathology; D013696:Temperature
D006131:Growth Inhibitors; D006003:Glycogen; D000242:Cyclic AMP; D011494:Protein Kinases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP