Studies of cyclic AMP action using mutant tissue culture cells.
S49 mouse lymphoma cell mutants, each with a specific defect in its ability to generate or respond to cyclic AMP, have been isolated. Analysis of the properties of these cells has begun to provide information on complex and significant biologic problems related to the cyclic AMP system.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D002453:Cell Cycle; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008938:Mitosis; D009154:Mutation; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000378:metabolism*; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta
D000319:Adrenergic beta-Antagonists; D005938:Glucocorticoids; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D011494:Protein Kinases; D000262:Adenylyl Cyclases; D007545:Isoproterenol