[Biological aspects of extracorporeal circulation].
Two problems are looked at in this work. That of glucose which is administered in considerable quantities during ECC and that of the iso-enzymes. The administration of glucose has two aims: one being the mechanical nature i.e. as an agent which decreases the risks of platelet aggregation, the other bio-energetic. But, owing to the CRABTREEE effect, an excess of glucose blocks the biosynthesis of ATP and a non-metabolisable structural analogue which has mechanical properties identical with glucose, such as fucose or rhamnose could be supplied instead. As far as the iso-enzymes are concerned, the author after having looked at the general value from the standpoint of signs and symptoms, suggests the study of two of them, cardiac lactic-dehydrogenase and the MB fraction of creatine phosphokinase could enable the follow-up of the course and of the consequences of extra-corporeal circulation.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D003402:Creatine Kinase / Q000097:blood*; D005112:Extracorporeal Circulation / Q000009:adverse effects; D005947:Glucose / Q000009:adverse effects; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*
D007527:Isoenzymes; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D005947:Glucose
Aspects biologiques de la circulation extra-corporelle