A new model for the study of septic shock.
Septic shock was produced in 28 healthy mongrel dogs by injecting 10(8) Escherichia coli organisms per kilogram into the gallbladder following division of the cystic artery and duct. Based upon the circulatory responses and the mortality, two distinct groups emerged. In one, the cardiac index decreased significantly, and the total peripheral resistance was elevated. In the other, the cardiac index increased significantly, and the total peripheral resistance was significantly lower. The average survival time in the former group was three days and, in the latter, five days. The physiopathology of this model is remarkably similar to that of human septic shock. Studies are planned to further describe this model to increase its utility in the study of septic shock.
D000818:Animals; D001769:Blood; D001794:Blood Pressure; D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D002496:Central Venous Pressure; D003326:Coronary Circulation; D004195:Disease Models, Animal; D004285:Dogs; D004926:Escherichia coli; D006321:Heart / Q000503:physiopathology; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow; D012772:Shock, Septic / Q000401:mortality / Q000503:physiopathology*; D014655:Vascular Resistance
D002245:Carbon Dioxide; D010100:Oxygen