Cerebrospinal fluid changes in experimental cardiopulmonary bypass using hemodilution with glucose water.
Cardiopulmonary bypass using hemodilution with isotonic glucose water was performed on seven dogs. Intense systemic metabolic acidosis, hyponatremia, hypochloremia, and hyperglycemia were accompanied by only comparatively small changes in the corresponding cerebrospinal fluid values. The data suggested that in the present study, cardiopulmonary bypass was not associated with gross disruptions of the barriers for bicarbonate, sodium, chloride, and glucose between blood and cerebrospinal fluid.
D000818:Animals; D001639:Bicarbonates / Q000097:blood / Q000134:cerebrospinal fluid; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001812:Blood-Brain Barrier / Q000187:drug effects; D001831:Body Temperature; D002245:Carbon Dioxide / Q000134:cerebrospinal fluid; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002555:Cerebrospinal Fluid / Q000032:analysis*; D002712:Chlorides / Q000097:blood / Q000134:cerebrospinal fluid; D004285:Dogs; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions; D008297:Male; D010952:Plasma Substitutes; D012964:Sodium / Q000097:blood / Q000134:cerebrospinal fluid
D001639:Bicarbonates; D001786:Blood Glucose; D002712:Chlorides; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D002245:Carbon Dioxide; D012964:Sodium; D005947:Glucose