[Note on the comparative effects of benzodiazepines and chlorpromazine on intracranial pressure in the dog].
The neutrality of the butyrophenones on intracranial pressure has been relatively well shown. That of the phenothiazines and benzodiazepine derivatives has been less well established. The authors studied, by a continuous method, the action of chlorpromazine, acepromazine and three benzodiazepines (diazepam, flunitrazepam and chlorazepam) on intracranial pressure and blood pressure in the dog. These substances seem to be definitely neutral on intracranial pressure, more so in the case of the benzodiazepines than for the promazines, the vasomotor action of which was perceptible when seen closely. The authors produce demonstrative graphs, illustrating the correlation of these two pressures.
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004285:Dogs; D007427:Intracranial Pressure / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects
D001569:Benzodiazepines; D002746:Chlorpromazine
Note sur les effets comparés des benzodiazépines et de la chlorpromazine sur la pression intracranienne du chien