[Synthesis and physico-chemical properties of the antihypertensive agent urapidil (author's transl)].
6-(3-[4-(o-Methoxyphenyl)-1-piperazinyl]-propylamino)-1,3-dimethyluracil (Urapidil, Ebrantil) is a new antihypertensive agent whose synthesis and physico-chemical properties are described. The size of the permeation constant KD of the passive transport through collodion-lecithin membranes and the value of the partition coefficient P in the neutral area indicate a good absorption and uniform distribution of the substance in the organism.
D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000378:metabolism; D001692:Biological Transport; D003101:Collodion; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D010539:Permeability; D010713:Phosphatidylcholines; D010879:Piperazines / Q000138:chemical synthesis* / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism
D000959:Antihypertensive Agents; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010879:Piperazines; D014498:Uracil; D003101:Collodion
Synthese und physikalisch-chemische Eigenschaften des Antihypertensivums Urapidil.