[Effect of izadrin, inderal and netalid on the periodic activity of the rabbit myometrium].
The contractility of an isolated rabbit uterus was studied. It was found that when used in low concentrations (1.10(-9)-1.10(-7) g/ml) isoprenaline, while stimulating the beta-adrenoreceptors of the uterus, inhibits its contractions, whereas in high concentrations (1.10(6)-1.10(-5) g/ml) it is capable of intensifying uterine contractions owing to stimulation of the uterine alpha-adrenoreceptors. Dihydroergotoxin (1.10(-6) g/ml), a blocking agent of alpha-adrenoreceptors, averts and eliminates the stimulating effect of isoprenaline on the uterus. Propranolol and netalide, blocking agents of the beta-adrenoreceptors, abolish the already developed depressing action of isoprenaline on the contractile activity of the uterus, but fail to prevent this effect with their preliminary application.
D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects*; D010507:Periodicity; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D004983:Ethanolamines; D004088:Dihydroergotoxine; D011433:Propranolol; D007545:Isoproterenol
Vliianie izadrina, inderala i netalida na periodicheskuiu aktivnost' miometriia krolikov