The effect of enflurane, isoflurane, fluroxene, methoxyflurane and diethyl ether anesthesia on ouabain tolerance in the dog.
Digitalis tolerance in dogs anesthetized with enflurane, isoflurane, fluroxene, methoxyflurane, and diethyl ether was compared with that in dogs anesthetized with pentobarbital. Ouabain dosage needed to cause ventricular tachycardia was significantly higher than that of pentobarbital with all agents except fluroxene, as was the LD50. The relative potency of these anesthetics in converting ouabain-induced ventricular tachycardia to sinus rhythm, in order of descending effectiveness, was: diethyl ether, methoxyflurane, enflurane, fluroxene, isoflurane, pentobarbital.
D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004361:Drug Tolerance; D004737:Enflurane / Q000494:pharmacology*; D004986:Ether / Q000494:pharmacology*; D004987:Ethers / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology*; D008733:Methoxyflurane / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology*; D010042:Ouabain / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D013610:Tachycardia / Q000139:chemically induced
D004987:Ethers; D005019:Ethyl Ethers; D008738:Methyl Ethers; D004986:Ether; D008733:Methoxyflurane; D010042:Ouabain; D004737:Enflurane; D007530:Isoflurane; D010424:Pentobarbital; D011188:Potassium; D006221:Halothane