[Effect of mutagenic metabolic activation of N-nitrosomorpholine on microorganisms].
Almost similar sensitivity is demonstrated of different methods of studying mutagenic metabolic activation of N-nitrosomorpholine (NM) in Salmonella typhimurium TA 1950 (host-mediated assay and the system of metabolic activation with rat liver homogenate). The role of correlation of certain ingredients of NM metabolic activation system with homogenates (homogenate and cofactor NADPH concentrations) is studied. The fact of influence of microsome protein activator (phenobarbital) on the NM mutagen activation effect is established.
D000818:Animals; D008099:Liver / Q000378:metabolism*; D009025:Morpholines / Q000378:metabolism / Q000494:pharmacology*; D009153:Mutagens / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009603:Nitroso Compounds / Q000378:metabolism / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*
D009025:Morpholines; D009153:Mutagens; D009603:Nitroso Compounds; D009249:NADP; D010634:Phenobarbital
Izuchenie éffekta mutagennoĭ metabolicheskoĭ aktivatsii N-nitrozomorfolina na mikroorganizmakh