Mutagenicity of halogenated ether anesthetics.
An in vitro microbial assay system employing two histidine-dependent strains of Salmonella typhimurium, TA1535 and TA100, was used to test the mutagenicities of enflurane, methoxyflurane, isoflurane and fluroxene. Enflurane, isoflurane and fluroxene in concentrations ranging from 0.01 to 30 per cent and methoxyflurane in concentrations ranging from 0.01 to 7 per cent were incubated with bacteria in the presence or absence of homogenates of liver prepared from rats pretreated with the enzyme inducer, Aroclor 1254. Enflurane, methoxyflurane, isoflurane, and urines from patients anesthetized with these agents were not mutagenic. Fluroxene, however, was highly mutagenic, and therefore poses a possible hazard for operating room personnel and patients.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004000:Dichloroethylenes / Q000494:pharmacology; D004737:Enflurane / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology; D007530:Isoflurane / Q000494:pharmacology; D008110:Liver Extracts / Q000494:pharmacology; D008297:Male; D008733:Methoxyflurane / Q000494:pharmacology; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*
D000777:Anesthetics; D004000:Dichloroethylenes; D004987:Ethers; D008110:Liver Extracts; D009153:Mutagens; D008733:Methoxyflurane; D004737:Enflurane; D007530:Isoflurane