[The state of prothrombin, plasminogen and fibrinogen in the newborn infant].
The esterase activity of thrombin and plasmin on artificial substrates was used to study the kinetics of these enzymes by Lineweaver and Burk's method. In the plasma of new-born infants, plasmin obtained from streptokinase has an avidity comparable with that in adults. Thrombin is obtained by the action of staphylocoagulase and taipan venom. Its avidity has important individual variations and is different from that in adults. An inhibitor is present both in the plasma and in the serum of the new-born. Fibrinogen was studied by variations in absorption of light during coagulation by thrombin. The abnormalities observed depend on the physical and clinical conditions of the medium (ph, osmolality). These characteristics depend on the age of the infant, but also seem to depend on the conditions of the sample and, in particular, on fibrinolytic reactions. The existence of foetal fibrinogen is discussed.
D000367:Age Factors; D001120:Arginine / Q000031:analogs & derivatives; D001549:Benzamides / Q000378:metabolism; D001780:Blood Coagulation Tests; D003030:Coagulase; D005312:Fetal Blood / Q000032:analysis; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000302:isolation & purification / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D009994:Osmolar Concentration; D010958:Plasminogen / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D012709:Serum Albumin; D012910:Snake Venoms; D013300:Streptokinase; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism
D001549:Benzamides; D003030:Coagulase; D012709:Serum Albumin; D012910:Snake Venoms; D011516:Prothrombin; D005337:Fibrin; D005340:Fibrinogen; D010958:Plasminogen; D001120:Arginine; D013300:Streptokinase; D013917:Thrombin; D005341:Fibrinolysin
Etat de la prothrombine, du plasminogène et du fibrinogène chez le nouveau-né