Postprandial gastro-oesophageal reflux in healthy people.
Distal oesophageal pH was monitored for three hours after a standard meal in 10 young healthy subjects without symptoms of gastro-oesophageal reflux. Episodes of reflux occurred in nine of these subjects; and, in five, oesophageal pH was less than 5 for between 11 and 75% of the first postprandial hour. Intermittent incompetence of the lower oesophageal sphincter after food must, therefore, be regarded as a normal phenomenon. The method described would be suitable for the evaluation of agents believed to weaken or to strengthen the lower oesophageal sphincter.
D000328:Adult; D004435:Eating; D004943:Esophagogastric Junction / Q000502:physiology*; D005260:Female; D005764:Gastroesophageal Reflux; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D011312:Pressure