Fortimicins A and B, new aminoglycoside antibiotics. II. Isolation, physico-chemical and chromatographic properties.
The aminoglycoside antibiotics fortimicins A and B produced by a naturally occurring strain Micromonospora sp. MK-70 were isolated from its fermentation beer. Fortimicins A and B were isolated as water-soluble, basic, white amorphous powders having molecular formula C17H35N5O6 and C15H32N4O5, respectively. Acid hydrolysis of fortimicin A indicated that it has one mole of glycine in its molecule while fortimicin B has not. Paper chromatography, silica-gel and carbon thin-layer chromatography revealed that fortimicins A and B are novel aminoglycoside antibiotics.
D000617:Aminoglycosides / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D003470:Culture Media / Q000032:analysis; D004355:Drug Stability; D005285:Fermentation; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008847:Micromonospora / Q000378:metabolism; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media