Effects of various diuretic agents in the mouse.
Diuretic effects of seven orally-acting diuretic agents have been examined in the mouse. The following compounds, examples of various types of orally active compound available, produced their characteristic diuretic effects: bendrofluazide, frusemide, ethacrynic acid, acetazolamide, triamterene, aminophylline and Su 15049A. The diuretic effects of the various agents were demonstrated under both water and saline-loading conditions. After allowing for differences in baseline sodium excretion, all diuretics except acetazolamide caused a further enhancement of sodium excretion after saline-loading compared with water-loading tests. The mouse possesses several advantages over the more commonly used rat since the range of diuretic responsiveness is greater. These results suggest that the mouse is a suitable species for diuretic testing.
D000086:Acetazolamide / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001539:Bendroflumethiazide / Q000494:pharmacology; D003510:Cyclohexanes / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004976:Ethacrynic Acid / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011188:Potassium / Q000652:urine; D011759:Pyrrolidines / Q000494:pharmacology; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology; D013045:Species Specificity; D014223:Triamterene / Q000494:pharmacology; D014867:Water / Q000494:pharmacology
D003510:Cyclohexanes; D004232:Diuretics; D011759:Pyrrolidines; D014867:Water; C001963:SU-15049; D000628:Aminophylline; D012965:Sodium Chloride; D001539:Bendroflumethiazide; D005665:Furosemide; D012964:Sodium; D004976:Ethacrynic Acid; D000086:Acetazolamide; D011188:Potassium; D014223:Triamterene