A metal complexing property of furosemide and bumetanide: determination of pK and stability constant.
Furosemide and bumetanide have been found to have different pK values and undergo complex formation with several metal ions in dioxane-water solution. pK values of these diuretics were determined. Evidence for complex formation was provided by a drop in pH during complex formation, production of a characteristic color and precipitation.
D002034:Bumetanide; D002614:Chelating Agents; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003300:Copper; D004232:Diuretics; D004355:Drug Stability; D005665:Furosemide; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008274:Magnesium; D015032:Zinc
D002614:Chelating Agents; D004232:Diuretics; D002034:Bumetanide; D003300:Copper; D005665:Furosemide; D008274:Magnesium; D015032:Zinc