Reversible inhibition of interferon-induced antiviral state by deoxyadenosine.
Deoxyadenosine reversibly inhibited the development of antiviral state (AVS) in chick embryo fibroblasts stimulated by interferon. Studies on cellular macromolecular syntheses in deoxyadenosine-treated cells suggested that the inhibition was related to nucleolar RNA synthesis. Reference experiments with actinomycin D and cordycepin (3'deoxyadenosine) also implied causal- or interrelation between AVS development and nucleolar RNA synthesis.
D000225:Adenine / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism; D002642:Chick Embryo; D046508:Culture Techniques; D003609:Dactinomycin / Q000494:pharmacology; D003839:Deoxyadenosines / Q000494:pharmacology*; D004336:Drug Antagonism; D007372:Interferons / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012845:Sindbis Virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D003839:Deoxyadenosines; D003609:Dactinomycin; D012313:RNA; D007372:Interferons; D000225:Adenine; D000241:Adenosine