Effect of two weeks' treatment with thioridazine, chlorpromazine, sulpiride and bromazepam, alone or in combination with alcohol, on learning and memory in man.
Forty paid healthy male students participated in two subacute experiments of 6 weeks each. In the first trial 20 of them received bromazepam, thioridazine, and placebo double blind cross over for 2 weeks each, and in the second trial the active agents administered to the other 20 participants were chlorpromazine and sulpiride. The tests used were paired associate learning with nonsense syllables and digit memory span. Before testing the subjects took either an alcoholic or a nonalcoholic bitter drink. As in the previous study from this laboratory, alcohol was found to impair learning capacity. Of the drugs used only bromazepam impaired learning significantly, and the combined effect of alcohol and bromazepam on learning capacity was very deleterious. The adrenolytic effect of drugs did not correlate with their effect on learning. Caution is necessary when prescribing bromazepam for active outpatients at least in doses used in this study.
D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001960:Bromazepam / Q000097:blood / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D010153:Paired-Associate Learning / Q000187:drug effects*; D011619:Psychotropic Drugs / Q000097:blood; D011817:Rabbits; D011955:Receptors, Drug; D013469:Sulpiride / Q000494:pharmacology*; D013881:Thioridazine / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D011619:Psychotropic Drugs; D011955:Receptors, Drug; D000431:Ethanol; D013469:Sulpiride; D013881:Thioridazine; D002746:Chlorpromazine; D001960:Bromazepam