[Anaphylactoid reactions following administration of plasma substitutes in man. Prevention of this side-effect of haemaccel by premedication with H1- and H2-receptor antagonists (author's transl)].
In a randomized controlled single blind trial in 50 volunteers the problem was investigated whether a combination of dimethpyrindene (0.1 mg/kg b.w.) and cimetidine (10 mg/kg b.w.) could prevent anaphylactoid or allergoid reactions following Haemaccel infusion. In the control group 6 anaphylactoid and 9 allergoid reactions were observed, in the H1 + H2-group, however, none of those reactions occured. No single wheal could be detected. It is considered appropriate to recommend the general use premedication of an H1 + H2-blocker before all anaesthetics and operations. This mainly depends on further clinical trials with the antihistaminic drugs concerning their side-effects under various conditions.
D000707:Anaphylaxis / Q000517:prevention & control*; D002927:Cimetidine / Q000627:therapeutic use; D004115:Dimethindene / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011097:Polygeline / Q000009:adverse effects*; D011108:Polymers / Q000009:adverse effects*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D011108:Polymers; D004115:Dimethindene; D002927:Cimetidine; D011097:Polygeline
Anaphylaktoide Reaktionen nach Applikation von Blutersatzmitteln beim Menschen. Verhinderung dieser Nebenwirkung von Haemaccel durch Prämedikation mit H1- und H2-Rezeptorantagonisten.