[Effect of analgestics and narcotics on the potentials of the posterior roots evoked by stimulation of the sensorimotor cortex].
Experiments set up on unanesthetized, curarized cats demonstrated that sodium oxybutyrate in doses of 75--200 mg/kg and nembutal in doses of 5--20 mg/kg prolong the duration of corticospinal posterior roots potentials (PRP). The initial effect of morphine and promedol in doses of 1--3 and 0.5--1 mg/kg, respectively was not only a longer duration (by 30--40 msec), but also a higher amplitude of the PRP, evoked by the stimulation of the sensomotor cortex. Phentanyl used in a dose range of 0.01 to 0.06 mg/kg did not produce any changes in the descending PRP. Anesthetics (sodium oxybutyrate, nembutal, ether) and analgesics (morphine, phenadon) inhibited the corticospinal PRP, when used in large doses.
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects*; D005283:Fentanyl / Q000494:pharmacology; D008691:Methadone / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D012978:Sodium Oxybate / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000187:drug effects*
D000701:Analgesics, Opioid; D009294:Narcotics; D009020:Morphine; D012978:Sodium Oxybate; D010424:Pentobarbital; D008691:Methadone; D005283:Fentanyl
Vliianie anal'getikov i narkotikov na potentsialy zadnikh koreshkov, vyzvannye razdrazheniem sensorno-motornoĭ kory