Characteristics of medicated and unmedicated microglobules recovered from complex coacervates of gelatin-acacia.
Medicated and unmedicated microglobules prepared from complex coacervates of Type A gelatin and acacia were recovered as water-insoluble powders consisting of discrete units, which were spontaneously revertible to highly disperse systems when suspended in water or physiological electrolyte solutions. Spherical microglobules containing up to 15% (w/w) sulfamerazine had a nominal diameter of 30 micron in aqueous suspension. Larger but irregularly shaped products containing up to 45% (w/w) sulfamerazine were also recovered. The relationships of the weight of sulfamerazine added per coacervate batch to weight yield and percent (w/w) included sulfamerazine of the microglobules were both linear.
D000045:Acacia; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D005780:Gelatin; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D013416:Sulfamerazine / Q000032:analysis
D005079:Excipients; D005780:Gelatin; D013416:Sulfamerazine