In vivo immune responses of mice during carcinogenesis by ultraviolet irradiation.
In these experiments, we tested in various in vivo assays the immune responses of inbred C3H/HeN(MTV-) (C3H-) mice during carcinogenesis by chronic exposure to UV irradiation. Although the UV-treated mice were unable to reject syngeneic UV-induced tumor transplants, they rejected H-2-incompatible tumor allografts and H-2-compatible skin allografts. The primary hemagglutinin response to sheep red blood cells was normal in these mice, as were the induction of a local graft-versus-host reaction with lymphoid cells from UV-irradiated donors and the induction of an inflammatory response to dimethyl sulfoxide in the footpads of UV-treated mice. An early transient depression of two reactions in UV-irradiated mice occurred: delayed hypersensitivity to dinitrochlorobenzene measured by footpad swelling and the graft-versus-host reaction in UV-irradiated recipients measured by the use of the popliteal lymph node weight gain assay. Both of these reactions returned to a normal level before the development of primary tumors. We conclude that the inability of UV-irradiated mice to reject syngeneic and autochthonous UV-induced tumors was not due to a generalized immunosuppressive effect of chronic UV irradiation.
D000818:Animals; D000951:Antigens, Neoplasm; D004137:Dinitrochlorobenzene / Q000276:immunology; D006084:Graft Rejection / Q000528:radiation effects; D006087:Graft vs Host Reaction / Q000528:radiation effects; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000528:radiation effects*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology*; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014466:Ultraviolet Rays
D000951:Antigens, Neoplasm; D004137:Dinitrochlorobenzene