[Calculation of the pH profile in the intercapillary regions of tumour tissues before and after long-term glucose infusion into the blood stream (author's transl)].
The pH profile in the intercapillary region of tumor tissue is calculated for normal (Case I) and enhanced glucose concentration in blood (Case II) which was increased by a factor of 4 for an extended period of time. The statement used, which takes into account the reduced lactic acid formation in the unsaturated region of cancer cell glycolysis, and the resulting solution of the lactic acid diffusion field equation are given. For Case II (conditions of cancer multistep therapy) and a capillary radius of 4 micrometer this yields the following pH values: Wall at venous end of the capillary 6.7 (or 6.5); at R greater than 12 micrometer, i.e. still in the vicinity of the capillary less  than 6.3: at R approximately 60 micrometer a minimum of 5.9. This rather good pH homogeneity is the prerequisite that all lytic actions and activation mechanism induced by a temporary extreme hyperacidification of the tumor tissue can take place in the major portion of the intercapillary region with a strength of adequate uniformity. Conclusions were drawn from these results with respect to the further planning of cancer therapy. This refers to the utilization of processes serving to increase primary damage to tumor tissue through body defense mechanisms, inhibition of cell proliferation as well as the applicability of new anticancer drugs (CMT Selectines) that are rendered active only in strongly hyperacidified foci of cancer. Moreover, this includes the possible use for increasing the secondary damage to tumor tissue by way of the lysosomal cytolysis, by drastic decrease of microcirculation and the damage of the capillaries in tumor tissue.
D000818:Animals; D002196:Capillaries / Q000502:physiology; D005947:Glucose / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism*; D051381:Rats; D012039:Regional Blood Flow
D007773:Lactates; D005947:Glucose
Berechnung des pH-Profils im Interkapillarraum der Krebsgewebe für die F¿lle mit und ohne Langzeit-Glukose-Infusion.