Rate constants of absorption versus physico-chemical parameters.
We examined the velocity constants of buccal absorption in the case of 10 drugs. The measurements tending towards what is the coherence between the velocity constants and the physico-chemical parameters of the drugs. On the basis of our investigations one can see that the dipol moment offers more reliable information for the size of the velocity of absorption than the lipid-water distribution ratio, molecular radii or diffusion constants. Our opinion is that it can be useful in modifying and planning the drug molecules.
D000042:Absorption; D002610:Cheek; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009061:Mouth Mucosa / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012995:Solubility
D004364:Pharmaceutical Preparations