Aminotetralins as selective beta-adrenergic agonists.
Aminotetralin derivatives M-8 and JOD-176, were studied in relation to isoproterenol for beta-adrenergic activity. M-8 and JOD-176 were found to be very weak in activating cardiac beta-receptors. These compounds were also found to be considerably more active in uterine and bronchial smooth muscle. Because these compounds were also shown to be very inactive in vascular smooth muscle, the possibility that beta-receptors in different smooth muscle types may also differ was suggested.
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists; D000818:Animals; D002415:Cats; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D010210:Papillary Muscles / Q000187:drug effects; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D009281:Naphthalenes; D015057:1-Naphthylamine; D015081:2-Naphthylamine