[Methods of determination of the turnover rate of neuromediators (author's transl)].
For the study of the effect of a treatment on a neuromediator, the determination of the turnover rate is often more interesting than the determination of the endogenous level of the mediator. Many methods have been used and they are not always isotopic ones. The principal methods are summarized here, especially for catecholamines and serotonin.
D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002250:Carbon Radioisotopes; D002395:Catecholamines / Q000096:biosynthesis; D002624:Chemistry, Clinical / Q000379:methods; D003864:Depression, Chemical; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors; D006801:Humans; D007553:Isotope Labeling; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D011339:Probenecid; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012701:Serotonin / Q000096:biosynthesis; D014316:Tritium; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002250:Carbon Radioisotopes; D002395:Catecholamines; D004791:Enzyme Inhibitors; D008996:Monoamine Oxidase Inhibitors; D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D014316:Tritium; D012701:Serotonin; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D011339:Probenecid; D009638:Norepinephrine
Méthodes de détermination des taux de renouvellement des neuromédiateurs