A serum haemagglutinating property dependent upon polycarboxyl groups.
A serum agglutinin reactive with red cells in the presence of polycarboxyl groups is reported. It is likely that this represents an additional example of the type of agglutinin previously described as agglutinating red cells in the absence of ionized calcium. Experimental evidence is presented indicating that it is free polycarboxyl groups that potentiate agglutination and that any metal ion, such as calcium, capable of chelating with these groups will prove to be inhibitory.
D000017:ABO Blood-Group System; D000368:Aged; D000373:Agglutinins / Q000032:analysis; D000918:Antibody Specificity; D002264:Carboxylic Acids / Q000494:pharmacology*; D002413:Cations, Divalent; D002951:Citrates / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology*; D005361:Ficain / Q000494:pharmacology; D006384:Hemagglutination / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009439:Neuraminidase / Q000494:pharmacology; D010206:Papain / Q000494:pharmacology
D000017:ABO Blood-Group System; D000373:Agglutinins; D002264:Carboxylic Acids; D002413:Cations, Divalent; D002951:Citrates; D004492:Edetic Acid; D009439:Neuraminidase; D010206:Papain; D005361:Ficain