[Spleen reactivity after BCG treatement: test and strain dependency of the response].
According to the strain used, spleen cells from mice injected two weeks before with 3 mg BCG, when they are engaged in a graft-versus-host reaction show a decrease in reactivity (C57Bl/6or AKR), an increase (DBA/2, BALB/C or SJL/J) or no modification (CBA, C3H). The in vitro responsiveness to PHA and conA of the treated spleen cells was lower than controls for all the strains studied. However, nylon column purified T cells from BCG treated mice showed a dissociated response, being less stimulated than normal cells by PHA and more so by ConA.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology*; D006087:Graft vs Host Reaction; D008213:Lymphocyte Activation; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013154:Spleen / Q000276:immunology*
D001500:BCG Vaccine
Réactivité des cellules spléniques après traitement par le BCG: variation de la réponse selon les tests et les legnées utilisées