Beta blockers in hypertension: a review.
The mechanisms of action, clinical use and untoward reactions of the beta-adrenergic blocking drugs, with particular attention to the role of these agents in the treatment of hypertension, are reviewed. Specific topics covered include the effect of beta-adrenergic blockade on the heart, renin secretion and the central nervous system; the efficacy and pharmacokinetics of beta-blocking agents; combinations with other drugs; patient acceptance and advantages; and toxicity and side effects. It is concluded that, with proper dosage titration, most hypertensive patients could probably be controlled on beta blockers alone or in combination with a diuretic.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002490:Central Nervous System / Q000187:drug effects; D004359:Drug Therapy, Combination; D006321:Heart / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007700:Kinetics; D012083:Renin / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D012083:Renin