5-Aryl-1,5-dihydro-2H-1,4-benzodiazepin-2-one derivatives as antianxiety agents.
A new series of 7-chloro- and 7-nitro-5-methoxy-5-phenyl-1,5-dihydro-2H-1,4-benzodiazepin-2-ones (7a, c--e) was synthesized and found to have potent antipentylenetetrazole activity. These compounds were also employed as intermediates in the synthesis of 3-substituted 1,3-dihydro-1,4-benzodiazepin-2-ones (8f--v).
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants; D001570:Benzodiazepinones / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones