Bioavailability of griseofulvin from a novel capsule formulation.
The in vivo availability of griseofulvin from a novel formulation has been compared with the micronized powder. The formulation technique involves the conversion of the hydrophobic surface of the drug to a hydrophilic one by treatment with a film forming polymer. This enhances the wettability of the power, and increases its dissolution rate. The results of the in vivo study show the formulation technique has increased the rate and extent of bioavailability of griseofulvin when compared with the non-treated powder.
D001682:Biological Availability; D002214:Capsules; D004339:Drug Compounding; D006118:Griseofulvin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D012995:Solubility; D013997:Time Factors
D002214:Capsules; D006118:Griseofulvin