Thrombin-induced vasodilation in the hindlimb (dog).
The objective of this study is to test the hypothesis that the vasodilation produced by intra-arterial injection of thrombin to the hindlimb of a dog may be caused by the secondary release or production of some vasodilating substance. The vasodilator response to thrombin was compared with the vasodilator response to acetylcholine, isoproterenol, histamine and serotonin before and after blockade with atropine, propranolol, phenergan or methyl-D-lysergic acid butanolamide (UML-491), respectively. Though the appropriate blocking agent blocked the vasodilator response to the respective drug, the thrombin-induced vasodilation was not blocked. These data support the hypothesis that thrombin-induced vasodilation is a response to the thrombin moiety.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006614:Hindlimb / Q000098:blood supply; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D012702:Serotonin Antagonists; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology*; D014666:Vasomotor System / Q000187:drug effects*
D006634:Histamine H1 Antagonists; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D012702:Serotonin Antagonists; D001285:Atropine; D011433:Propranolol; D013917:Thrombin; D007545:Isoproterenol; D000109:Acetylcholine; D008784:Methysergide