Enhancement of ethonol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors.
Male Swiss-Webster mice were made physically dependent on ethanol using the ethanol vapour inhalation technique. Animals pretreated with methysergide, a known 5-hydroxytryptamine receptor blocking agent, had significantly greater alcohol-induced withdrawal convulsions than saline pretreated controls. These findings suggest that the reduction of 5-HT at receptor sites may result in the augmentation of the withdrawal convulsions.
D000818:Animals; D000431:Ethanol; D006801:Humans; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D011985:Receptors, Serotonin / Q000187:drug effects; D012640:Seizures / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology
D011985:Receptors, Serotonin; D012701:Serotonin; D000431:Ethanol; D008784:Methysergide