Modification of the action of pentagastrin on acid secretion by botulinum toxin.
I.v botulinum toxin after 60-90 min abolished the dose-response relationship between pentagastrin and gastric acid secretion in anesthetized rats and guinea-pigs. The toxin reduced but did not abolish the acid stimulatory effect of histamine. As expected, the acid response to vagal stimulation was abolished and that to methacholine in rats was unaltered by the toxin.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists; D008688:Methacholine Compounds / Q000494:pharmacology; D010418:Pentagastrin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D014630:Vagus Nerve / Q000502:physiology
D006634:Histamine H1 Antagonists; D008688:Methacholine Compounds; D001905:Botulinum Toxins; D010418:Pentagastrin; D000109:Acetylcholine