[Participation of non-specific rat liver microsome oxidases in destruction of Nl-furanidylpyrimidines].
N1-(3'-Butyrolactono)-5-fluorouracil, N1-(2'-furanidyl) 5-trifluoromethyluracil, N1-(2'-furanidyl)-5-fluoracil are split in the rat organism with the formation of free 5-fluorouracil. The destruction of the C--N bonds in the molecule of the N1-(2'-furanidyl)-5-fluoracil takes place in the liver microsomes. This process is strengthened by NADPH and weakened by SKF-525A. All the three furanidylpyrimidines studied induced differential spectra of type I in the suspension of the liver microsomes. This fact testifies to the interaction of these substances with the cytochrome P-450.
D000818:Animals; D001711:Biotransformation; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D005641:Tegafur / Q000378:metabolism
D005641:Tegafur; D009249:NADP; D011335:Proadifen; D005472:Fluorouracil
Uchastie nespetsificheskikh oksidaz mikrosom pecheni krys v razrushenii Nl-furanidilpirimidinov