The Wien effect in compensated metabolic acidosis.
CSF and blood acid-base values were measured in compensated metabolic acidosis, induced in anesthetized dogs by infusion of dilute HCl during hyperventilation. We observed cerebral blood flow-related steady-state differences in PCO2 between CSF and arterial venous blood from the brain. The steady-state values of CSF-blood PCO2 differences and blood H+ activity were intermediate to those observed by us previously during uncompensated acidosis and alkalosis (J. Appl. Physiol. 34: 249-254, 1973). These results are consistent with predictions of the "charged membrane hypothesis" proposed by us to explain CSF and blood acid-base relationship during uncompensated acid-base derangements (J. Appl. Physiol. 34: 243-248, 1973).
D000138:Acidosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D000818:Animals; D001158:Arteries; D001921:Brain / Q000098:blood supply; D002245:Carbon Dioxide / Q000097:blood* / Q000134:cerebrospinal fluid; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D006985:Hyperventilation / Q000097:blood / Q000134:cerebrospinal fluid; D014680:Veins
D002245:Carbon Dioxide