Long-term narcotic exposure reduces caudate cyclic nucleotide levels, protein phosphorylation and tyrosine hydroxylase activities.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D008297:Male; D009021:Morphine Dependence / Q000378:metabolism; D009294:Narcotics / Q000494:pharmacology*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010750:Phosphoproteins / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D009294:Narcotics; D009712:Nucleotides, Cyclic; D010750:Phosphoproteins; D000242:Cyclic AMP; D014446:Tyrosine 3-Monooxygenase; D006152:Cyclic GMP