Benzodiazepines and reproduction of swiss-webster mice.
Chronic dietary administration of 6 different benzodiazepine tranquilizers (chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, and nitrazepam) to breeding pairs of Swiss-Webster mice resulted in alterations of the normal patterns of reproductive behavior and fetal growth. Significant decreases in mating performance were seen among mice given diets containing 0.15% chlordiazepoxide, 0.05% diazepam, 0.05 and 0.15% oxazepam, 0.02 and 0.10% prazepam, 0.10% flurazepam, and 0.025% nitrazepam. Offspring in all drug treatments showed significantly depressed body weights at birth.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000633:toxicity; D001569:Benzodiazepines; D001724:Birth Weight / Q000187:drug effects; D003864:Depression, Chemical; D004971:Estrus / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects / Q000502:physiology; D006128:Growth; D008297:Male; D051379:Mice; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines