Formation of sulfone metabolites from chlorpromazine and perazine in man.
Didesmethylchlorpromazine sulfone [gamma-(2-chlorophenothiazinyl-10)-propylamine sulfone] has been isolated from the urine of a patient under continuous chlorpromazine therapy and identified by mass spectrometry. The same compound was present in organs of rats after injection of the corresponding sulfide. The Cl-free analogue, gamma-(phenothiazinyl-10)-propylamine sulfone, was excreted by patients receiving perazine and by a volunteer after ingestion of the primary amine sulfoxide.
D000328:Adult; D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D001711:Biotransformation; D002746:Chlorpromazine / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D010464:Perazine / Q000378:metabolism*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013450:Sulfones / Q000378:metabolism* / Q000652:urine
D014150:Antipsychotic Agents; D013450:Sulfones; D010464:Perazine; D002746:Chlorpromazine