Rat brain gamma-glutamyl transpeptidase: effects of alcohol.
Adult rats were exposed to increasing air ethanol concentrations over a 12-day period without the use of pyrazole. Gamma-glutamyl transpeptidase levels were determined from various regions of rat brain. The enzyme levels in the pons-medulla, mid-brain and the striatum increased significantly during the 12-day exposure to ethanol. Other areas of the brain displayed a slight increase in enzyme activity, but not a significant level.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D000431:Ethanol; D005723:gamma-Glutamyltransferase