[Effect of blocking the neuronal and extraneuronal uptake of bioamines on the adrenosensitizing action of tricyclic antidepressants].
Tests conducted on isolated and denervated preparations of the rat seminal duct brought evidence that tricyclic antidepressants (melipromine, noverile and azaphen) when employed in low concentrations (1-10(-9) g/ml) produced an adrenosensitizing effect. Denervation with the subsequent block by desoxycorticosterone (1-10(-5) g/ml) of exteraneuronal amine uptake did not alter the position, shape and inclination of the "concentration-effect" noradrenaline curves received in the presence of noverile and cocaine. It is believed that there exists a predominance of the postsynaptic mechanism of the aminosensitizing action of tricyclic antidepressants on the smooth muscle organ.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D003984:Dibenzazepines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009121:Muscle Denervation; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D010078:Oxazines / Q000494:pharmacology; D051381:Rats; D013737:Testis / Q000187:drug effects
D000929:Antidepressive Agents, Tricyclic; D003984:Dibenzazepines; D010078:Oxazines; D003042:Cocaine; D007099:Imipramine; D009638:Norepinephrine
Vliianie vykliucheniia neĭronal'nogo i ékstraneĭronal'nogo zakhvata bioaminov na adrenosensibili-ziruiushchee deĭstvie tritsiklicheskikh antidepressantov