Specific absorbed antithymocyte globulin for incubation treatment in human marrow transplantation.
The experimental data show that absorption of ATG with liver-kidney homogenate and CLL and LCL cells stepwise removed the hemopoietic toxicity, whereas the specific activity against T lymphocytes remained. Although the mode of action of absorbed ATG could not be tested in the first clinical case, the successful experiments in rodents together with the fact that the incubation treatment was tolerated by the patient may provide a new way of preventing fatal GVH reactions in man.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification*; D000918:Antibody Specificity; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D006087:Graft vs Host Reaction; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007163:Immunosorbent Techniques; D051379:Mice; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*; D013696:Temperature; D013997:Time Factors; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic