[Effects of a coffee-antacid-mixture and a commercial coffee with regard to gastrin, pH and gastric secretion (author's transl)].
The influence of a coffee-antazid-mixture was investigated at 30 patients with diseases of the stomach (17 with duodenal ulcer, 6 with gastric ulcer and 7 with chronic gastritis) in comparison to a commercial coffee. The parameters measured were the gastric basal acid output, the continuous registration of the pH by an intragastric electrode and the serum gastrin concentration before and after the application of the tests substances. 75% of the patients with duodenal ulcer showed a positive effect by means of a greater elevation of the intragastric pH after application of the mixture in comparison to coffee. The effect was strongly correlated to the basal acid ouptput. In the group with gastric ulcer and that with duodenal ulcer under the influence of the mixture the pH after the initial rise decreased to less deeper values. There was a close relationship to the patterns of gastric ulcer as well with chronic gastritis there was an additional facourable effect on the symptoms of abdominal pain which occured after coffee and not after the mixture. The group with chronic gastritis showed no difference between the pure coffee and the coffee-antacid-mixture. A possible relationship of the products of coffee roasting and the adsorptive properties of the antacid is discussed.
D000328:Adult; D000368:Aged; D000863:Antacids / Q000494:pharmacology*; D002908:Chronic Disease; D003069:Coffee; D005215:Fasting; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000503:physiopathology; D005755:Gastrins / Q000378:metabolism*; D005756:Gastritis / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000503:physiopathology; D013272:Stomach Diseases / Q000503:physiopathology
D000863:Antacids; D003069:Coffee; D005755:Gastrins
Wirkungsvergleich eines Kaffee-Antazidum-Gemisches und eines herkömmlichen Pulverkaffees am pH-Wert des Magensaftes und der Gastrinsekretion.