Increased resistance of an interferon-resistant cell subline to the toxic effect of double-stranded RNA.
The toxicity of double-stranded (ds) f2-phage RNA for interferon-treated L cells and an interferon-resistant subline of L cells (CVS cells) was compared. The interferon-resistant subline proved to be about 20 times more resistant to ds RNA than the parent L cells. The degree of toxicity of ds RNA was dependent on the concentration of interferon to which the cells were exposed.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003090:Coliphages; D004351:Drug Resistance; D007372:Interferons / Q000494:pharmacology; D007739:L Cells / Q000187:drug effects*; D051379:Mice; D012367:RNA, Viral / Q000633:toxicity*
D012367:RNA, Viral; D007372:Interferons