[Effect of the beta-adrenergic blocking agent bupranolol on the plasma renin activity in normotensive rats].
The effects of the beta-adrenergic blocking agent 3-tert.-butyl-amino-1-(6'-chloro-3'-methylphenoxy)-propan-2-ol hydrochloride (bupranolol; KL 255; Betadrenol) on the plasma renin activity (PRA) of normotensive rats were studied in comparison to propranolol. Bupranolol (10--100 microgram/kg) reduced basal PRA and inhibited the isoproterenol as well as dihydralazine induced increase of PRA in a dose dependent fashion. Bupranolol exhibited an effect 2--4 times stronger than that of propranolol. The PRA inhibiting effects of bupranolol seem to be linked to its beta-receptor blocking properties.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004078:Dihydralazine / Q000037:antagonists & inhibitors; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012083:Renin / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011433:Propranolol; D012083:Renin; D007545:Isoproterenol; D004078:Dihydralazine
Untersuchungen über die Beeinflussung der Plasmareninaktivität normotoner Ratten durch den beta-Rezeptorenblocker Bupranolol.