The effect of lorazepam on the vasoconstriction of fear.
Volume-pulse digital plethysmography performed under ideal conditions on relatively fit adults has shown that lorazepam 4 mg intravenously abolishes the vasoconstriction of fear and restores the digital vasodilatation of the tranquil mind. The sedative effect of the drug is prolonged and is associated with several hours of anterograde amnesia from the time of its administration. The drug has no effect on the vasoconstrictor reaction to cold, pain, noise or other forms of adrenergic stimuli. Lorazepam seems to modify or prevent the psychomotor reactions which may complicate ketamine anaesthesia.
D000328:Adult; D000648:Amnesia, Retrograde / Q000139:chemically induced; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004325:Dreams; D005239:Fear / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D010991:Plethysmography; D011229:Preanesthetic Medication; D011674:Pulse / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D014665:Vasodilator Agents; D008140:Lorazepam