[Elucidation of the mechanism of nicotinic acid flush in the animal experiment (author's transl)].
The reddening of the ears of guinea pigs following the administration of nicotinic acid and its derivatives is regarded as an animal experiment for the human flush-reaction. In agreement with the observations in humans we found that the reddening effects decreased after repeated administration of xantinol nicotinate (Complamin). The results demonstrate that the reddening of the ears of guinea pigs--and presumably flushing in humans as well--is a complex event. The liberation of prostaglandins, histamine and serotonin, and first of all, cholinergic reactions, seem to be involved.
D000319:Adrenergic beta-Antagonists; D000818:Animals; D004347:Drug Interactions; D006168:Guinea Pigs; D009539:Nicotinic Acids / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D013997:Time Factors; D014971:Xanthinol Niacinate / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D009539:Nicotinic Acids; D010276:Parasympatholytics; D011448:Prostaglandin Antagonists; D012702:Serotonin Antagonists; D014971:Xanthinol Niacinate
Tierexperimentelle Versuche zur Klärung des Mechanismus des Nikotinsäure-Flush.