Choline administration: activation of tyrosine hydroxylase in dopaminergic neurons of rat brain.
The administration of choline in doses previously shown to elevate brain acetylcholine concentrations also increases the activity of tyrosine hydroxylase in rat caudate nuclei. This response can be blocked by atropine, a muscarinic antagonist. These findings indicate that choline-induced increases in acetylcholine concentrations may be associated with parallel changes in the amount of the neurotransmitter released into synapses.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002421:Caudate Nucleus / Q000201:enzymology*; D002794:Choline / Q000494:pharmacology*; D004298:Dopamine; D004789:Enzyme Activation / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000201:enzymology; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D011976:Receptors, Muscarinic; D001285:Atropine; D014446:Tyrosine 3-Monooxygenase; D002794:Choline; D000109:Acetylcholine; D004298:Dopamine