[Changes in transmitter release at frog neuromuscular junction induced by 4-aminopyridine].
4-aminopyridine (4-AP) at micromolar concentrations, increases the end-plate potential amplitude in curarized preparations and the mean quantal content in every preparation tested, but the spontaneous release is not modified by 4-AP. These results can explain the anticurare activity observed in the wole animal or in vitro. 4-AP prolongs the falling phase of the muscle action potential without change in the muscle membrane potential.
D000200:Action Potentials / Q000187:drug effects; D000588:Amines / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*; D011893:Rana esculenta; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
D000588:Amines; D018377:Neurotransmitter Agents; D011725:Pyridines; D008274:Magnesium; D002118:Calcium; D014403:Tubocurarine
Modifications de la libération du transmetteur à la jonction neuromusculaire de grenouille sous l'action de l'amino-4 pyridine