The rat brain as a "deep compartment" in the kinetics of a common metabolite of prochlorperazine and perphenazine.
N-[gamma-(2-Chlorophenothiazin-10-yl)propyl]ethylenediamine (Cl-PPED), a common metabolite of prochlorperazine and perphenazine, was orally administered to male rats  at a dose of 50 mg/kg, and its concentrations in plasma, liver, lung, kidney, and brain were followed from 6 hr to 40 days after dosage. Small quantities were measured by two-dimensional thin-layer chromatography of a fluorescent derivative and in situ fluorometry of the chromatograms. The kinetic behavior of Cl-PPED in brain differed from that in other tissues in that the concentration maximum was  achieved later and the elimination half-life was distinctly longer (8 days vs. 1.2-3 days). Cl-PPED was evenly among the three major brain regions. Subcellular fractionation of liver and brain revealed preferential localization in mitochondria.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D010546:Perphenazine / Q000378:metabolism*; D011346:Prochlorperazine / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors
D010546:Perphenazine; D011346:Prochlorperazine