Phospholipase A in pulmonary secretions of patients with alveolar proteinosis.
This report presents evidence for the presence of phospholipase A2 (EC 3.1.1.4) activity in the insoluble pulmonary secretions of patients with alveolar proteinosis. The enzyme activity has a pH optimum between 7.5 and 8.5 and is stimulated by deoxycholate and Ca2+.
D002118:Calcium / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000201:enzymology*; D010713:Phosphatidylcholines / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism*; D011649:Pulmonary Alveolar Proteinosis / Q000201:enzymology*; D007507:Therapeutic Irrigation
D005227:Fatty Acids; D010713:Phosphatidylcholines; D003840:Deoxycholic Acid; D010740:Phospholipases; D002118:Calcium