Differential blockade of bicuculline convulsions by neuroleptics.
Haloperidol, pimozide, sulpiride and metoclopramide blocked bicuculline-induced convulsions in mice. Chlorpromazine and thioridazine exhibited this effect at low doses whereas at higher doses (e.g. 1 mg/kg i.p. chlorpromazine) this activity was no longer apparent. A dose of phenoxybenzamine which was inactive alone (7.5 mg/kg i.p.) completely blocked the anti-bicuculline effect of sulpiride and antagonized that of haloperidol. These data are interpreted as indicating that intact noradrenergic systems are necessary for the anti-bicuculline effect of the neuroleptics.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001640:Bicuculline / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007546:Isoquinolines / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D010775:Photic Stimulation; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D014150:Antipsychotic Agents; D007546:Isoquinolines; D001640:Bicuculline