Barbiturate physical dependence in mice: effects of neuroleptics and diazepam on the withdrawal syndrome.
Diazepam (8 mg/kg) quickly and effectively reduced the incidence of withdrawal symptoms in phenobarbital dependent C57BL/6J male mice. In contrast, the neuroleptic agents employed (chlorpormazine, haloperidol, or reserpine) or alpha-methyl-p-tyrosine tended to exacerbate the withdrawal syndrome. Chlorpromazine and haloperidol were approximately equally potent in their effects; this would suggest that their antidopaminergic effects were not the primary mechanism of action for the increased incidence of withdrawal symptoms.
D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001463:Barbiturates; D002746:Chlorpromazine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use*; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D010634:Phenobarbital / Q000627:therapeutic use; D012110:Reserpine / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D014150:Antipsychotic Agents; D001463:Barbiturates; D008781:Methyltyrosines; D012110:Reserpine; D006220:Haloperidol; D003975:Diazepam; D002746:Chlorpromazine; D010634:Phenobarbital