[The effect of ACTH and several antimetabolites of vitamin B6 on the activity of tyrosine aminotransferase in the liver of intact and hypophysectomized rats].
ACTH injected intraperitoneally in a dose of 140 Units per 1 kg of body weight to intact rats or to rats subjected to hypophysectomy 24 hours before the experiment produced an increase in the activity of tyrosine-aminotrasferase in the liver (4.5 or 2.5 times, respectively) in comparison with the normal. D-cycloserine and its dimere injected intraperitoneally to the intact starving rats in a dose of 2.0-2.5 g per 1 kg of body weight produced in 4 hours a sharp elevation in the liver of the activity of tyrosine-amino transferase, whose induction constituted 75 and 180%, respectively. 24 hours after hypophysectomy D-cycloserine produced no induction of this enzyme in the rat liver; in difference from this, the D-cycloserine dimere produced an induced formation of tyrosine-aminotransferase (comparable with ACTH) in the liver of hypophysectomized rats. This indicated that the induction mechanism of tyrosine-aminotransferase in the liver of rats under the effect of D-cycloserine and its dimere differed.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003523:Cycloserine / Q000494:pharmacology*; D004789:Enzyme Activation; D007016:Hypophysectomy; D008099:Liver / Q000201:enzymology*; D008297:Male; D011108:Polymers / Q000494:pharmacology; D051381:Rats; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D011108:Polymers; D000324:Adrenocorticotropic Hormone; D003523:Cycloserine; D014444:Tyrosine Transaminase
Vliianie AKTG i nekotorykh antimetabolitov vitamina B6 na aktivnost' tirozinaminotransferazy v pecheni intaktnykh i gipofizéktomirovannykh krys