Clorazepate: double blind crossover comparison of a single nightly dose with diazepam thrice daily in anxiety.
In a double blind cross-over study in 40 patients with mild to moderate anxiety, clorazepate 15 mg at bedtime was as effective as diazepam on global rating and slightly superior on target symptom assessment. There was a significantly higher incidence and frequency of side effects during diazepam treatment. Occurrence of side effect related to plasma diazepam, and anxiolytic effect related to plasma nordiazepam. These results are discussed in relation to convenience of the single dose regimen and psychomotor performance.
D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003009:Clorazepate Dipotassium / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos
D014151:Anti-Anxiety Agents; D010919:Placebos; D003009:Clorazepate Dipotassium; D003975:Diazepam