[Neuroleptics and sexual dysfunction in man. Neuroendocrine aspects].
Sexual behaviour and fertility of schizophrenic patients are discussed. The various sexual dysfunctions induced by neuroleptics, such as decrease in libido, troubles of ejaculation and impotence, are described and related to their various mechanisms of action. The central antidopaminergic effect of neuroleptics would be responsible for an overall non-specific decrease in libido. Their effect upon the autonomous nervous system would explain ejaculation disturbances. Their endocrine action (increase in prolactine) would produce impotence. The possibility of treatment of these endocrinological troubles by bromocriptine is discussed.
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D004542:Ejaculation / Q000187:drug effects; D007172:Erectile Dysfunction / Q000139:chemically induced; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007989:Libido / Q000187:drug effects*; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012725:Sexual Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D001971:Bromocriptine
Neuroleptiques et dysfonctions sexuelles chez l'homme. Aspects neuroendocriniens.