Lack of correlation between changes in cyclic nucleotides and subsequent induction of tyrosine hydroxylase in rat adrenal medulla.
Pretreatment of rats with dexamethasone (2.5 mumol/kg, a dose which blocks the release of ACTH from the pituitary gland) abolished the reserpine mediated increase in cAMP and the increase in the cAMP/cGMP ratio in the adrenal medulla. In contrast, the reserpine-mediated induction of tyrosine hydroxylase (TH) remained unchanged. Hypophysectomy had a similar effect to dexamethasone treatment. Since changes in cAMP and changes in the cAMP/cGMP ratio are not indispensible prerequisities for the subsequent induction of TH, a causal relationship between the two phenomena seems to be excluded.
D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004790:Enzyme Induction; D007016:Hypophysectomy; D008297:Male; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D051381:Rats; D012110:Reserpine; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis*
D009712:Nucleotides, Cyclic; D003907:Dexamethasone; D012110:Reserpine; D000242:Cyclic AMP; D014446:Tyrosine 3-Monooxygenase; D006152:Cyclic GMP