Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues.
The synthesis and some pharmacological effects of 16 3-aryl analogues of butaclamol, a new antipsychotic drug, are described. The animal models were predictive of neuroleptic activity as well as side effects commonly associated with neuroleptic therapy. The results indicate that the 3-substituent plays a critical role with regard to the potency of the compounds as well as to their tendencies to induce extrapyramidal side effects and/or hypotension.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D002069:Butaclamol / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D002375:Catalepsy / Q000139:chemically induced; D003213:Conditioning, Psychological / Q000187:drug effects; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D003986:Dibenzocycloheptenes / Q000138:chemical synthesis*; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000633:toxicity; D006801:Humans; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D002069:Butaclamol; D003913:Dextroamphetamine; D004837:Epinephrine