Diazepam and flunitrazepam as induction agents for cardiac surgical operations.
Diazepam and flunitrazepam were compared in equipotent doses as induction agents for premedicated patients having cardiac surgery. Both drugs caused a significant fall in arterial blood pressure, a rise in Paco2 and a fall in Pao2. There was no significant difference between the two drugs in onset time of anaesthesia, cardiovascular or respiratory depression, or quality of induction. There was also no significant difference from induction with thiopentone in these respects. Diazepam, over a 0.2 to 0.6 mg/kg range of doses showed no difference in toxicity, although induction was clinically smoother with the higher dose.
D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D006348:Cardiac Surgical Procedures; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D004341:Drug Evaluation; D005445:Flunitrazepam / Q000008:administration & dosage / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011229:Preanesthetic Medication; D013997:Time Factors
D014151:Anti-Anxiety Agents; D002245:Carbon Dioxide; D005445:Flunitrazepam; D003975:Diazepam; D010100:Oxygen