Preliminary experience with vascularised Fallopian tube transplants in the human female.
The preoperative screening and postoperative case records of two patients that underwent vascularised Fallopian tube transplants are described. In both cases the operation was followed by immunological rejection. This was chronic and clinically quiescent in the first patient, but an accelerated rejection associated with a pyrexial illness and a rise in serum fibrinogen, blood platelet and serum lactic dehydrogenase levels was observed in the second case. Technical feasibility was demonstrated but further progress in the field of Fallopian tube transplants will be dependent on the development of safer techniques of immunosuppression considered necessary for graft survival.
D000328:Adult; D002908:Chronic Disease; D005187:Fallopian Tubes / Q000098:blood supply / Q000473:pathology / Q000637:transplantation*; D005260:Female; D005334:Fever / Q000209:etiology; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007247:Infertility, Female / Q000601:surgery*; D008722:Methods; D009336:Necrosis; D011183:Postoperative Complications; D013369:Subphrenic Abscess / Q000209:etiology; D014019:Tissue Donors; D014184:Transplantation, Homologous