Impaired Sertoli cell function in experimental cryptorchidism in the rat.
The production of testicular androgen-binding protein (ABP), as a measure of Sertoli cell function, was studied after unilateral or bilateral experimental cryptorchidism in adult rats. Two or 4 weeks after the testis had been translocated to the abdomen, no major changes were found in the concentration of ABP per mg protein, although there was a marked and progressive decrease in ABP content per testis. However, the rate of ABP production was greatly decreased, as measured by the accumulation of ABP during 16-h ligation of the efferent ducts or by the production of ABP by testis mince in an in vitro system. This indicates that the Sertoli cell function is severly impaired by the intra-abdominal position.
D000818:Animals; D001665:Binding Sites; D003456:Cryptorchidism / Q000378:metabolism*; D004822:Epididymis / Q000378:metabolism; D008297:Male; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface; D012611:Scrotum / Q000378:metabolism; D012708:Sertoli Cells / Q000378:metabolism*; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
D011506:Proteins; D011956:Receptors, Cell Surface; D013739:Testosterone