Duration of action of analgesic supplements to anesthesia. A double-blind comparison between morphine, fentanyl and sulfentanil.
In a double-blind trial, in a total of 45 patients,  sulfentanil was compared with fentanyl and morphine in equipotent doses, as a narcotic supplement to anesthesia. Initially, morphine was shown to have a significantly longer duration of effect than fentanyl and sulfentanil, which for the first 3 doses had similar durations of action to each other. Later doses of fentanyl, however, had an extended effect, presumably because of cumulation. This was not seen with sulfentanil.
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000368:Aged; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000768:Anesthesia, General; D000813:Anilides / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D000813:Anilides; D010880:Piperidines; D009020:Morphine; D005283:Fentanyl