Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin.
Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin was inactivated the least of the aminoglycosides. Both penicillins inactivated each aminoglycoside to a similar extent by a degree which varied according to the medium of incubaiton, the least inactivation being seen in pooled human serum and the most in phosphate buffer at pH 7.4.
D000583:Amikacin / Q000097:blood; D000617:Aminoglycosides / Q000097:blood*; D000900:Anti-Bacterial Agents / Q000097:blood*; D001711:Biotransformation; D002228:Carbenicillin / Q000097:blood*; D004347:Drug Interactions; D005839:Gentamicins / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010406:Penicillins / Q000097:blood*; D013982:Ticarcillin / Q000097:blood*; D014031:Tobramycin / Q000097:blood
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D000583:Amikacin; D013982:Ticarcillin; D002228:Carbenicillin; D014031:Tobramycin