Loss of histochemically demonstrable catecholamines in the glomus cells of the carotid body after alpha-methyl-para-tyrosine treatment.
A statistically significant decrease in the intensity of catecholamine fluorescence of some carotid body glomus cells was observed after inhibition of the enzyme tyrosine hydroxylase by injection of 80 mg/kg alpha-methyl-paratyrosine. The intensity of the formaldehyde-induced fluorescence was measured in individual glomus cells. The maximum decrease in the intensity was observed 4 to 6 hr after the alpha-methyltyrosine injection. This suggests a rapid turnover in the catecholamines of the carotid body.
D000818:Animals; D002344:Carotid Body / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D002395:Catecholamines / Q000378:metabolism*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D002395:Catecholamines; D008781:Methyltyrosines; D014446:Tyrosine 3-Monooxygenase