Physiological and pathophysiological aspects of gastrointestinal peptide hormones.
The author made a review about the origin, the biochemistry the physiological and pathological roles of gastrointestinal peptide hormones. They originate from the APUD cell system, chemically from the ancient growth hormone, or placental lactogen. The theoretical prosecgastrin's first sequencies form the "secretin family", the tail sequencies form the "gastrin family". The author describes many details of their effects on the different gastrointestinal organs, they behave mainly antagonistic way to each other. Finally a discussions is given about their role in the development of peptic ulcer, in the WDHA syndrome and in malabsorption.
D001078:APUD Cells / Q000502:physiology; D002454:Cell Differentiation; D004377:Dumping Syndrome / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D010437:Peptic Ulcer / Q000378:metabolism; D012633:Secretin / Q000378:metabolism / Q000502:physiology; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D005934:Glucagon