Stimulation of immune reactivity by methoxy-substituted glycerol ethers incorporated into the feed.
In mice, the plaque-forming cell response to sheep red blood cells was stimulated by a mixture of methoxy-substituted glycerol ethers isolated from Greenland shark liver oil and by synthetic 1-0-(2-methoxyhexadecyl)-glycerol, given in the diet. In preliminary experiments, this synthetic compound also increased the ability of parental spleen cells to induce graft-vs.-host reactions in F1 hybrid mice. Glycerol ethers occur in the bone marrow fat of mammals and in the membrane phospholipids. It is postulated that the methoxy-substituted glycerol ethers supplied in the diet may stimulate the bone marrow and/or may be incorporated into membrane lipids, thereby changing the structure and function of the membranes.
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology; D004032:Diet; D005989:Glycerides / Q000494:pharmacology*; D006087:Graft vs Host Reaction / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D008738:Methyl Ethers / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA
D005989:Glycerides; D008738:Methyl Ethers