A macromolecular transducer as illustrated by trout hemoglobin IV.
Oxygen binding by trout Hb IV has been investigated as a function of pH up to 10 atmospheres (1 MPa) of pure O2. The results bring out an extreme proton-oxygen linkage, which gives rise to a Root effect. They are discussed in relation to the function of the hemoglobin as an oxygen pump. The system is of special interest as providing a prototype of a macromolecule acting as a transducer by coupling two allosterically linked reactions.
D000494:Allosteric Regulation; D000818:Animals; D006454:Hemoglobins / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D011485:Protein Binding; D012487:Salmonidae / Q000097:blood*; D013816:Thermodynamics; D014337:Trout / Q000097:blood*
D006454:Hemoglobins; D010108:Oxyhemoglobins; D010100:Oxygen