Inhibitory effect of mercaptoamino acids on lysino-alanine formation during alkali treatment of proteins.
Alkali treatment of food proteins converts some amino acid residues to the unnatural amino acid lysinoalanine which has been found to cause kidney damage when fed to rats. Formation of lysinoalanine was essentially prevented when isolates of soy protein and casein were exposed to alkali in the presence of thio-alamino acids such as cysteine. The results suggest that added thiols minimize the formation of potentially toxic lysinoalanine.
D000409:Alanine / Q000031:analogs & derivatives*; D002364:Caseins; D055598:Chemical Phenomena; D002621:Chemistry; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000031:analogs & derivatives*; D008623:Mercaptoethanol; D010940:Plant Proteins; D013025:Glycine max; D013438:Sulfhydryl Compounds
D002364:Caseins; D010940:Plant Proteins; D013438:Sulfhydryl Compounds; D008623:Mercaptoethanol; D008239:Lysine; D000409:Alanine