[Experimental analysis of interference between alpha-adrenergic stimulants with anti-hypertensive activity and the narcotic activity of pentobarbital].
The interactions of 3 classical alpha-adrenergic antihypertensives of prevalently central type (St 155 or clonidine St 600; BR 750 or guanabenz) with the narcotic effects of pentobarbital have been investigated in the Mus musculus. Interferences between convulsant drugs and spontaneous and coordinatory motor activity were also analysed in comparative studies.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004336:Drug Antagonism; D004597:Electroshock; D005260:Female; D006143:Guanabenz / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced*
D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D006143:Guanabenz; D010424:Pentobarbital; D003000:Clonidine; D010433:Pentylenetetrazole
Analisi sperimentale delle interferenze tra alpha-adrenergici stimolanti con attività anti-ipertensiva e narcosi da pentobarbital.