[Role of salivary ribonuclease in pathogenesis of periodontosis].
In patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline RNAases was found. The RNAases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar layer in aged Wistar rats and the spontaneous periodontal disease in cats. In experiments with golden hamsters salivary RNAase was found to penetrate through mucosa in active form. The purified salivary RNAase inhibited the protein biosynthesis in rabbit gingiva. Intensive atrophic alterations were produced in periodontal tissues of Wistar rats by means of purified salivary RNAase.
D000539:Alveolar Process / Q000032:analysis; D000818:Animals; D002403:Cathepsins / Q000032:analysis; D002415:Cats; D006224:Cricetinae; D004247:DNA / Q000032:analysis; D005881:Gingiva / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006909:Hydroxyproline / Q000032:analysis; D066298:In Vitro Techniques; D009584:Nitrogen / Q000032:analysis; D010510:Periodontal Diseases / Q000209:etiology*; D010518:Periodontitis / Q000201:enzymology; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism* / Q000494:pharmacology; D012463:Saliva / Q000201:enzymology*; D012469:Salivary Glands / Q000601:surgery
D011506:Proteins; D012313:RNA; D004247:DNA; D012260:Ribonucleases; D010744:Phosphoric Monoester Hydrolases; D002403:Cathepsins; D009584:Nitrogen; D006909:Hydroxyproline
Rol' ribonukleazy sliuny v patogeneze parodontoza