[Immunologic study of viral hepatitis].
The author discusses the various immunological methods used to demonstrate antigen in serum hepatitis. This antigen is made up of three main types of particles: a spherical particle, a tub-like structure and a second larger spherical particle with a hexagonal centre, described by DANE. The centre of DANE's particle is immunologically distinct from its surface. The immune complexes thus formed by antibody links between surface antigens play a major role in extrahepatic manifestations of serum hepatitis. The various subtypes of antigen can be used as a basis for geographical and epidemiological study of the disease. The centre of DANE's particle is considered to be the virus itself. It cannot be cultured with current methods but it can be transmitted to chimpanzees. The antibody reacting with the surface antigen is protective. In conclusion, the author observed that an increase in serum transaminases in anesthetized patients occurred only after halothane. This suggests that liver damage after administration of halothane may be due to a direct effect of the product or its metabolites.
D000914:Antibodies, Viral; D000937:Antigen-Antibody Reactions; D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens; D006801:Humans; D013499:Surface Properties
D000914:Antibodies, Viral; D006511:Hepatitis B Antigens
Etude immunologique des hépatites virales