The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites.
Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013343:Styrenes / Q000378:metabolism*; D013997:Time Factors
D013343:Styrenes