Metabolism of cyclobenzaprine in the dog.
Ten metabolites of cyclobenzaprine, accounting for approximately 50% of the urinary radioactivity, were identified in the urine of dogs to which the labeled drug had been given orally. These included the 1,2-dihydrodiol, three phenolic derivatives, the N-oxide, the 10,11-epoxide, the 10,11-glycol, desmethylcyclobenzaprine, and the glucuronide conjugates of desmethylcyclobenzaprine and cyclobenzaprine. The metabolites were excreted in both the free and conjugated states. Unchanged cyclobenzaprine was present in only minor amounts.
D000639:Amitriptyline / Q000031:analogs & derivatives; D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003986:Dibenzocycloheptenes / Q000378:metabolism* / Q000652:urine; D004285:Dogs; D005965:Glucuronates / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D009125:Muscle Relaxants, Central / Q000378:metabolism* / Q000652:urine
D003986:Dibenzocycloheptenes; D005965:Glucuronates; D009125:Muscle Relaxants, Central; D000639:Amitriptyline; C004704:cyclobenzaprine