[Changes in the H-alloantigen-recognizing function of mouse lymphoid cells following hydrocortisone administration].
The capacity of spleen, thymus, and bone marrow cells of intact (control) and of hydrocortisone-treated mice CBA to induce the lymph node type of graft-v-host reaction (GVHR) in hybrids F1 (CBA X c57bl) was studied. After hydrocortisone injection (2.5 mg per mouse) the donor spleen cells became more active in GVHR, considering the value of lymph node indices and immunoblast content in the regional lymph node as compared with a control group. Following transplantation of thymus cells taken from the hydrocortison-treated donors the immunoblast count was higher, although the lymph node weight remained the same as in the control group. On the contrary, following the transfer of the bone marrow cells from the hydrocortisone-treated mice the lymph nodes enlarged, while the immunoblast count remained as low as in control. Consequently, exogenously conditioned increase in the hydrocortisone level was accompanied by an enrichment of the spleen and thymus cell populations with T-lymphocytes, proliferating in response to H-alloantigens.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004351:Drug Resistance; D006087:Graft vs Host Reaction; D006854:Hydrocortisone / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000166:cytology / Q000187:drug effects* / Q000637:transplantation; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects
D006854:Hydrocortisone
Izmenenie H-alloantigenraspoznavatel'noĭ funktsii limfoidnykh kletok mysheĭ posle vvedeniia gidrokortizona.