[Experimental studies of the specificity and aspecificity of a beta-adrenolytic agent, bunitrolol (Kö 1366)].
In basis of our experimental researches bunitrolol presented: a) beta-adrenolytic activity prevailingly at cardiac level (superior to propranolol and practolol) in respect to vascular, tracheal, bronchial, uterus, intestinal and metabolic level; b) beta-adrenergic intrinsic activity; c) local anesthetic activity; d) chinidino-like activity; e) antiarrhythmic activity; f) hypotensive activity with interferences at the level of vasomotor centres, of the barosensitive zones, of the renin secretion and of the purinergic periphery.
D000818:Animals; D001001:Anura; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004983:Ethanolamines / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D050356:Lipid Metabolism; D009130:Muscle, Smooth / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014666:Vasomotor System / Q000187:drug effects
D001786:Blood Glucose; D004983:Ethanolamines; D005230:Fatty Acids, Nonesterified; D011412:Propanolamines; D011433:Propranolol
Ricerche sperimentali sulla specificità ed aspecificità di un beta-adrenolitico, il bunitrololo (Kö 1366).