[Effect of neonatal injections of estradiol, testosterone and cryproterone acetate on plasma and testicular testosterone and on the genital system in adult male mice].
On day old male mice received a single injection of oestradiol benzoate, testosterone propionate or cyproterone acetate in order to study their action on testicular development, particularly testosterone secretion. Oestrogenization of newborn males leads, when the animals mature, to a high proportion or cryptorchidism, to atrophy of testes and seminal vesicles, and inhibition of spermatogenesis. Testosterone levels were reduced in the plasma. Testosterone propionate produced moderate reduction of testicular weight but spermatogenesis was not impaired. Plasma testosterone level was reduced. Cyproterone acetate increased significantly testicular testosterone level.
D000818:Animals; D000831:Animals, Newborn; D003456:Cryptorchidism / Q000139:chemically induced; D003534:Cyproterone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012671:Seminiferous Tubules / Q000187:drug effects; D013737:Testis / Q000032:analysis / Q000187:drug effects* / Q000254:growth & development; D013739:Testosterone / Q000032:analysis / Q000097:blood / Q000494:pharmacology*
D013739:Testosterone; D004958:Estradiol; D003534:Cyproterone
Effets de l'injection néo-natale d'oestradiol, de testostérone et d'acétate de cyprotérone sur la testostérone testiculaire et plasmatique et sur l'appareil génital de la souris male adulte