[Mechanism of the antianginal action of oxyfedrine].
Oxyphedrine was found to depress the tonicity of coronary vessels, increase the coronary circulation volume, the oxygen uptake by the heart and also to exert a positive inoand chronotropic action in test with urethan and cloralose anesthetized cats. These effects were caused by stimulation of the beta-adrenoreceptors of the heart and vessels. In non-anesthetized cats oxyphedrine did not produce tachycardia. Furthermore, under certain conditions (when superimposed on a preliminary administration of practolol- a beta-blocking agent) oxyphedrine can exert a direct inhibitory action on the myocardium.
D000318:Adrenergic beta-Agonists; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010099:Oxyfedrine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D000700:Analgesics; D011427:Propiophenones; D011943:Receptors, Adrenergic, beta; D010099:Oxyfedrine
K mekhanizmu antianginal'nogo deĭstviia oksifedrina.