Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice.
A "feedback suppressor T cell" highly dependent on signals from Ly 1 T helper cells for activation is described. The signal from the Ly 1 cell binds to Fc-like receptors on macrophage membranes. The feedback suppressor cell expresses all three Ly antigens as well as the Qa 1 antigen on its surface, is very sensitive to low doses of cyclophosphamide, disappears relatively rapidly after adult thymectomy, and cannot be demonstrated in NZB mice 6 weeks or older.
D000367:Age Factors; D000818:Animals; D002462:Cell Membrane; D003520:Cyclophosphamide / Q000276:immunology; D005246:Feedback; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB; D010641:Phenotype; D013601:T-Lymphocytes; D013934:Thymectomy
D003520:Cyclophosphamide