[Central action of WA-335-BS, a substance with peripheral antiserotonin and antihistaminic activity].
In rats and mice the serotonin and histamine antagonistic drug 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335-BS) caused stronger central sedative effects than did cyproheptadine. WA 335-BS also displayed stronger activity against reserpine- and central tremorine-induced effects than did cyproheptadine and it slightly enhanced d-amphetamine-induced effects: therefore it may have antidepressant properties. WA 335-BS proved to be very effective against isolation-induced aggression in male mice. The comparatively small anxiolytic effects may have been caused in part by the central antiserotonin properties. Like cyproheptadine, WA 335-BS increased food consumption in cats. In EEG-experiments in the conscious rabbit the serotonin-antagonistic drugs WA 335-BS and cyproheptadine exerted stronger depressant activity on the arousal reactions than did the neuroleptic chlorpromazine. The results of our animal studies suggest WA 335-BS to be an antidepressant with sedative properties.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D001007:Anxiety; D001066:Appetite / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D002746:Chlorpromazine / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects; D003533:Cyproheptadine / Q000494:pharmacology; D003863:Depression; D005260:Female; D000882:Haplorhini; D006634:Histamine H1 Antagonists; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011817:Rabbits; D012640:Seizures / Q000517:prevention & control; D012702:Serotonin Antagonists
D000873:Anthracenes; D006634:Histamine H1 Antagonists; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D002746:Chlorpromazine
Zentrale Wirkungen von WA 335-BS, einer Substanz mit peripherer Antiserotonin- und Antihistamin-Wirkung