Alpha-adrenergic blocking properties of droperidol on isolated blood vessels of the dog.
Concentrations of droperidol which caused a shift to the right of the dose-response curve to noradrenaline in the pulmonary artery and the saphenous vein of the dog did not affect myogenic activation by K+; they did not inhibit spontaneous activity of portal-mesenteric veins. Droperidol inhibited the contractile response to nerve stimulation, but did not affect the evoked release of 3H-noradrenaline. These experiments indicate that the vasodilator properties of smaller doses of droperidol are a result of its ability to block alpha-adrenergic receptors.
D000317:Adrenergic alpha-Antagonists; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004329:Droperidol / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008642:Mesenteric Veins / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D011188:Potassium / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects; D012501:Saphenous Vein / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D004329:Droperidol; D011188:Potassium; D009638:Norepinephrine