Influence of pH on the efficacy of pilocarpine.
Pilocarpine 4% solutions at pH 4.1 and 5.8 were compared in a double-blind clinical trial on 24 eyes of patients with primary open-angle glaucoma. Each drug was used over a period of 1 week. No significant difference in the lowering of intraocular pressure was found, and the near-neutral solution of pilocarpine was found to be equally stable when compared to the acid solution over a 6-month period.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010862:Pilocarpine / Q000627:therapeutic use*
D010862:Pilocarpine