Hemodialysis in methyprylon overdose. Some pharmacokinetic considerations.
Serial measurements of serum methyprylon concentration were made in the case of a 14-year-old girl who ingested an overdose of the drug. Our data indicate that, in the presence of high plasma levels of the drug, much longer half-lives than the usually reported four hours may be observed. It is postulated that saturation kinetics may be a possible mechanism for this observation. The striking clinical improvement after six hours of hemodialysis demonstrated the efficacy of this mode of treatment in our patient.
D000293:Adolescent; D005260:Female; D006207:Half-Life; D006801:Humans; D007688:Kidneys, Artificial; D010881:Piperidones / Q000097:blood / Q000506:poisoning*; D006435:Renal Dialysis
D010881:Piperidones