[Disorder of porphyrin metabolism in thallium intoxication (author's transl)].
A 19-year old male ingested in suicidal attempt 750 mg of thallium. He developed the characteristic symptoms of thallium intoxication. During the acute phase the urinary excretion of porphyrins and porphyrin precursors was largely increased. The percentage distribution of the individual metabolites of heme synthesis revealed a preponderance of kopro- and uroporphyrin. This constellation (kopro- greater than uro- greater than tricarboxylic porphyrin) differs appreciably from that one in lead intoxication. The observation of increased urinary excretion of porphyrins and their precursors in a possibly particular spectrum in thallium intoxication is of special interest for differential-diagnostic reasoning. In each case of a toxic disorder of porphyrin metabolism thallium intoxication ought to be considered a possible cause.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000931:Antidotes; D005290:Ferric Compounds / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D011166:Porphyrins / Q000378:metabolism*; D006435:Renal Dialysis; D013405:Suicide; D013610:Tachycardia / Q000139:chemically induced; D013793:Thallium / Q000506:poisoning*; D013885:Thiosulfates / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D000931:Antidotes; D005290:Ferric Compounds; D011166:Porphyrins; D013885:Thiosulfates; D013793:Thallium
Störung des Porphyrinstoffwechsels bei der Thalliumvergiftung.