Effects of L-glutamine of acetylsalicylic acid or taurocholic acid-induced gastric lesions and secretory changes in pylorus-ligated rats under normal or stress conditions.
An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric musoca in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa under stress was dose-dependent. Stress itself (23 degrees C, 7 hr) did not induce any appreciable changes in gastric mucosa under stress wasic mucosa of rats. L-glutamine, given together with SAS or TCA, significantly prevented the potentiated development of SAS- or TCA-induced gastric lesions in stressed rats. L-glutamine also prevented in varying degrees the reduction of acid and increment of Na+ ion in gastric juice accumulated in stressed rats in response to ASA or TCA.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004347:Drug Interactions; D005750:Gastric Juice / Q000032:analysis / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005973:Glutamine / Q000494:pharmacology* / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D008297:Male; D011188:Potassium / Q000032:analysis; D011708:Pylorus / Q000502:physiology*; D051381:Rats; D012964:Sodium / Q000032:analysis; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*; D013656:Taurocholic Acid / Q000494:pharmacology*
D005973:Glutamine; D013656:Taurocholic Acid; D012964:Sodium; D001241:Aspirin; D011188:Potassium