The metabolism of p-methoxyamphetamine in dog and monkey. O-demethylation as a major route.
p-Hydroxyamphetamine (PHA) and p-hydroxybenzoic acid (PHBA) have been isolated by gas-liquid chromatography (GC) as urinary metabolites of p-methoxyamphetamine (PMA) in dogs and rhesus monkeys. The amounts of PMA excreted unchanged in the total 24-hr urine samples in dogs and monkeys were 26% and 3%, respectively, of the total administered doses. The amounts of the pharmacologically active metabolite PHA excreted in 24-hr urine samples were 13% in the dog and 44% in the monkey. In the dog, 72% of the PHA was present as free (unconjugated) PHA, whereas in the monkey the amount of PHA present in the free form was only 14%.
D000662:Amphetamines / Q000652:urine*; D000818:Animals; D002849:Chromatography, Gas; D003640:Dealkylation; D004285:Dogs; D000882:Haplorhini; D006868:Hydrolysis; D062385:Hydroxybenzoates / Q000652:urine; D008253:Macaca mulatta; D008297:Male; D013045:Species Specificity
D000662:Amphetamines; D062385:Hydroxybenzoates