Gas-liquid chromotographic determination of perazine, thioridazine and thioridazine metabolites in human plasma.
A gas-liquid chromatographic method for the detection of perazine, thioridazine and its major metabolites in human plasma is presented. Repeated extraction, an internal standard and a temperature program with flame ionization detection make possible accurate and reproducible results with patients on therapeutic doses of these drugs. Examples of chromatograms after extraction of plasma are given.
D014150:Antipsychotic Agents / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008722:Methods; D010464:Perazine / Q000097:blood*; D013696:Temperature; D013881:Thioridazine / Q000097:blood* / Q000378:metabolism
D014150:Antipsychotic Agents; D010464:Perazine; D013881:Thioridazine