Hemorrhagic shock in dogs. Comparison of treatment with shed blood alone versus shed blood plus Ringer's lactate: intravascular pressures, cardiac output, oxygen consumption, arteriovenous oxygen differences, extracellular fluid PO2, electrolyte changes, and survival rates.
The purpose of our study of hemorrhagic shock in dogs was to examine the efficacy of adding Ringer's lactate to shed blood replacement in increasing animal rates. The standard Wiggers' hemorrhagic shock technic was used in two groups of ten animals each. Intravascular pressures, cardiac outut, oxygen consumption, arteriovenous oxygen differences, extracellular fluid PO2 and pH, electrolyte changes, and survival rates were determined. There was a positive correlation between changes in cardiac output, central venous oxygen content, and PO2 and extracellular fluid PO2 as measured using subcutaneously implanted Silastic tubing and perforated plastic balls. Four of the dogs that received shed blood alone survived, whereas five of the dogs that received shed blood plus Ringer's lactate survived. This difference was not statistically significant.
D000818:Animals; D001769:Blood; D001794:Blood Pressure; D002302:Cardiac Output; D002496:Central Venous Pressure; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000627:therapeutic use*; D008274:Magnesium / Q000097:blood; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010313:Partial Pressure; D010952:Plasma Substitutes / Q000008:administration & dosage; D011188:Potassium / Q000097:blood; D011651:Pulmonary Artery; D012771:Shock, Hemorrhagic / Q000401:mortality / Q000628:therapy*; D014655:Vascular Resistance
D007773:Lactates; D010952:Plasma Substitutes; D008274:Magnesium; D011188:Potassium; D010100:Oxygen