Difference in the number of insulin binding sites between cortisol-sensitive and cortisol-resistant lymphoma P1798 cells.
Cortisol-sensitive and cortisol-resistant lymphoma P1798 cells specifically bind [25I]insulin. Resistant lymphocytes bind 40% less insulin than sensitive cells. These results suggest that insulin (or insulin-like substances) may play a role in growth regulation and/or response of this tumor to glucocorticoid therapy.
D002478:Cells, Cultured; D006854:Hydrocortisone / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D011956:Receptors, Cell Surface; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors
D007328:Insulin; D011956:Receptors, Cell Surface; D006854:Hydrocortisone