[Determination of isoniazid in blood plasma].
The authors describe a new method of estimation of isoniazid in biological fluids, based on the formation and extraction of aluminium chelate obtained after combination of the isoniazid with salicylic aldehyde. The study of conditions of defecation and reaction permits one to eliminate interference with the metabolites, especially the acido-labile metabolites and obtain results comparable with those of microbiological methods.
D000447:Aldehydes; D000535:Aluminum; D001681:Biological Assay; D002614:Chelating Agents; D006801:Humans; D006835:Hydrazones; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007538:Isoniazid / Q000097:blood*; D012459:Salicylates; D012997:Solvents
D000447:Aldehydes; D002614:Chelating Agents; D006835:Hydrazones; D007477:Ions; D012459:Salicylates; D012997:Solvents; D000535:Aluminum; D007538:Isoniazid
Dosage de l'isoniazide dans le plasma sanguin