[Protein inhibitor of cyclic nucleotide phosphodiesterase in the retina in hereditary degeneration].
Thermostable protein fraction from retina of rats with hereditary retinal dystrophy (Hunter and Campbell strains) did not inhibit cyclic nucleotide phosphodiesterase. At the same time an inhibitory component, found in retina of Wistar rat, rabbit, frog and lamprey, was similar to the component from bovine retina. Quantity of the inhibitory component in normal rat retina decreased considerably within postnatal period (12 days--3 months). Thermostable proteins, isolated from Campbell rat retina, differed from that of Hunters' one by electrophoretic properties while both preparations were dissimilar to the protein of normal rat. Protein bands, containing inhibitory component from dystrophic rat retina, appear to be less distinct as compared to those of normal rat. These proteins, eluated from the bands of Campbell rats, activated phosphodiesterase but the preparations from Hunter rats did not influence on it.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000037:antagonists & inhibitors*; D000367:Age Factors; D000818:Animals; D001001:Anura; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D005136:Eye Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007798:Lampreys; D010726:Phosphodiesterase Inhibitors; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina; D012162:Retinal Degeneration / Q000201:enzymology*; D012174:Retinitis Pigmentosa / Q000201:enzymology
D005136:Eye Proteins; D010726:Phosphodiesterase Inhibitors; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases
Belkovyĭ ingibitor fosfodiésterazy tsiklicheskikh nukleotidov v setchatki pri ee nasledstvennoĭ degeneratsii.