Reduced myocardial ATP and creatine phosphate in diabetes: role of 2,3-diphosphoglycerate.
Observations are presented which suggest that myocardial cellular hypoxia may account for the reduction in myocardial ATP and CP in the ketoacidotic diabetic state. It is suggested that reduced 2,3-diphosphoglycerate adversely affects oxygen release from the red blood cell, thereby leading to myocardial cellular hypoxia.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004163:Diphosphoglyceric Acids / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology; D007662:Ketosis / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010725:Phosphocreatine / Q000378:metabolism*; D051381:Rats
D004163:Diphosphoglyceric Acids; D007328:Insulin; D010725:Phosphocreatine; D002245:Carbon Dioxide; D000255:Adenosine Triphosphate; D010100:Oxygen