[Effect of the structure of liposomal membrane surface layer on the binding of phenothiazines].
By using a fluorescent 3-metoxybenzatrone probe the binding of the phenothiazine series drugs (chlorpromazine, triftazine, aethaperazine) with phospholipid vesicles--liposomes, was investigated. Cholesterol is shown not to affect the binding of these drugs with liposomes. The surface charge of liposomes influences only the combination with the chlorpromazine membranes. With a higher positive charge of the membranes the binding of chlorpromazine diminishes in force.
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D002642:Chick Embryo; D002746:Chlorpromazine / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005456:Fluorescent Dyes; D008041:Linoleic Acids / Q000378:metabolism; D008081:Liposomes / Q000302:isolation & purification / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D010546:Perphenazine / Q000378:metabolism; D010743:Phospholipids / Q000302:isolation & purification; D011485:Protein Binding / Q000187:drug effects; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014268:Trifluoperazine / Q000378:metabolism
D014150:Antipsychotic Agents; D005456:Fluorescent Dyes; D008041:Linoleic Acids; D008081:Liposomes; D008565:Membrane Proteins; D010743:Phospholipids; D014268:Trifluoperazine; D002784:Cholesterol; D010546:Perphenazine; D002746:Chlorpromazine
Vliianie struktury poverkhnostnogo sloia membran liposom na sviazyvanie fenotiazinov.