Antidiuresis induced by beta1- and beta2-adrenergic agonists in ethanol-anesthetized rats.
The beta1- and beta2-components in antidiuresis and sodium retention induced by beta-adrenergic agonists were analysed in ethanol-anesthetized, water-diuretic rats. Intravenous infusions of isoprenaline, salbutamol and carbuterol did not affect insulin clearance but increased plasma renin concentration to the same same extent. Propranolol completely blocked the decreases in urine volume (V) and urinary sodium excretion (UNaV) induced by isoprenaline; practolol (beta1-blocker) inhibited only the decrease in UNaV and butaxamine (beta2-blocker) inhibited only the decrease in V. The ratios of doses of beta-agonists which decreased UNaV and by 50% (ED50 UNaV decrease/ED50 V decrease) were 0.34, 0.68, 1.56 and 2.36 for isoprenaline, tretoquinol, salbutamol and carbuterol, respectively. This increasing order of the ratios coincided with the order reported for the preponderance of the beta2- over beta1-component of these agonists. These results indicate that the decrease in UNaV induced by beta-agonists is related to beta1 stimulation, while the decrease in V is related to beta2 stimulation.
D000318:Adrenergic beta-Agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D003864:Depression, Chemical; D004231:Diuresis / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D010710:Phosphates / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D010710:Phosphates; D000431:Ethanol; D012964:Sodium; D007545:Isoproterenol