[Demonstration of T-cell activation using synthetic polynucleotides].
The present data show that SPN have a striking influence on thymus dependent T cells. The enhancing effect of gvh reactions on antibody formation against thymus dependent antigens give a good explanation for the antitumor effects of this substance.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects; D011063:Poly A-U / Q000494:pharmacology; D011070:Poly I-C / Q000494:pharmacology; D011119:Polynucleotides / Q000494:pharmacology*; D051381:Rats; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*; D014184:Transplantation, Homologous
D011119:Polynucleotides; D011063:Poly A-U; D011070:Poly I-C
Nachweis der T-Zell aktivierenden Funktion von synthetischen Polynukleotiden