Gardimycin, a new antibiotic from Actinoplanes. III. Biological properties.
The new antibiotic gardimycin has an interesting in vitro antibacterial activity against Gram-positive bacteria and Neisseria gonorrhoeae. Parenteral administration gives a high degree of protection against experimental infections in mice. It also shows some chemotherapeutic activity when given rectally.
D000192:Actinomycetales / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media; D010455:Peptides