The effects of etilefrine on blood vessels in the rat tail.
Etilefrine was found to constrict blood vessels in the rat tail through a mechanism which was partly dependent on the sympathetic nerves present in these vessels. The response to the drug was enhanced by pretreagment with noradrenaline and cocaine, and totally abolished by the alpha-receptor antagonist phentolamine. When compared with several other sympathomimetic agents which were tested on the vessel, etilefrine appeared to have a low order of vasoconstrictor activity. These findings would seem to have considerable relevance to the clinical situation where an attempt has been made to use etilefrine in the treatment of patients with orthostatic hypotension.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D005039:Etilefrine / Q000494:pharmacology*; D006145:Guanethidine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008680:Metaraminol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013623:Tail / Q000098:blood supply; D013997:Time Factors; D014439:Tyramine / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects*
D006892:Hydroxydopamines; D010656:Phenylephrine; D008680:Metaraminol; D012110:Reserpine; D003042:Cocaine; D009638:Norepinephrine; D014439:Tyramine; D004837:Epinephrine; D010646:Phentolamine; D005039:Etilefrine; D006145:Guanethidine