Latent infection and measles meningoencephalitis in Syrian hamsters.
A strain designated 42-Edmonston was isolated from the brain of a Syrian hamster 30 days after inoculation during the neonatal period with the reference "wild" measles virus strain Edmonston which produced a latent infection accompanied by production of measles antibody and insignificant pathomorphological changes. Intracerebral inoculation with the 42-Edmonston strain of newborn, one day-and 5-7-day-old Syrian hamsters resulted in the development of acute measles encephalitis with typical clinical symptoms and pathomorphological changes. It is suggested that selection and adaptation of a neurotropic measles virus variant probably had occurred in the course of virus persistence in the Syrian hamster brain.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006224:Cricetinae; D004195:Disease Models, Animal; D008459:Measles virus / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D008590:Meningoencephalitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008647:Mesocricetus
D000914:Antibodies, Viral; D000956:Antigens, Viral