On the influence of prostaglandin F2alpha-induced labor at term on the metabolism and coagulation of mother and fetus.
11 pregnancies at term were terminated by dilatation of the uterine cervix, low amniotomy, and by intravenous administration of PGF2alpha. The average infusion time was 3 hours 55 minutes, and the average total dose of PGF2alpha amounted to 2.0 mg. Parameters of acid-base changes, carbohydrate and energic state changes, gas metabolism, and changes in coagulation and fibrinolysis in mother and in fetus were analyzed during labor and after birth. Labor activity and fetal cardiac action were monitored cardiotocographically. Checked against 50 uncomplicated spontaneous deliveries, we found no disadvantageous changes in the parameters investigated.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D050260:Carbohydrate Metabolism; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005333:Fetus / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007751:Labor, Induced; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D011460:Prostaglandins F; D002245:Carbon Dioxide; D010100:Oxygen