Some properties of hemoglobin Gun Hill.
Hb Gun Hill has been found in an asymptomatic black female living in Alabama; neither her parents nor her two siblings carry the variant. The deletion of five amino acid residues in the beta chain of Hb Gun Hill (alpha2beta2 91-95 deleted) causes this variant to have a high oxygen affinity, an interaction coefficient of unity and an absence of the Bohr effect. The rate of oxidation of liganded Hb Gun Hill by the ferricyanide ion follows first-order kinetics. Hb Gun Hill is to a great extent dissociated into dimers over a wide range of pH values.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000032:analysis; D005260:Female; D005292:Ferricyanides; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption
D000596:Amino Acids; D005292:Ferricyanides; D006455:Hemoglobins, Abnormal