[The renin-aldosterone system in essential hypertension--hypotensive action of beta adrenergic blocking agents and variation of the renin-aldosterone system (author's transl)].
The effect of beta adrenergic blocking agents on the renin release from the kidney and its possible role in the hypotensive effect of these agents were studied in patients with essential hypertension. Oxprenolol induced a significant decrease in systolic blood pressure and PRA, but the correlation between the decrease in blood pressure and the decrease in PRA was not found. When the effect of carteolol, another beta adrenergic blocking agent, was studied, a decrease in blood pressure was obtained, but there was a rise in PRA. These observations suggest that the hypotensive action of beta adrenergic blocking agents does not result from their effects on PRA.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D010096:Oxprenolol / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use*; D011804:Quinolines / Q000627:therapeutic use*; D012083:Renin / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011804:Quinolines; D000450:Aldosterone; D010096:Oxprenolol; D012083:Renin