Formation of nucleoside 5'-polyphosphates from nucleotides and trimetaphosphate.
When solutions of nucleoside 5'-phosphates and trimetaphosphate are dried out at room temperature, nucleoside 5'-polyphosphates are formed. The Mg++ ion shows a superior catalytic function in this reaction when compared with other divalent metal ions. Starting with nucleoside 5'-phosphates, Mg++ and trimetaphosphate, the predominant products in the nucleoside 5'-polyphosphate series pnN are p4N, P7N and p10N. Nucleoside 5'-diphosphates yield p5N and p8N, nucleoside 5'-triphosphates give p6N and p9N. The prebiological relevance of these reactions is discussed.
D000227:Adenine Nucleotides; D001464:Barium; D005075:Biological Evolution; D002118:Calcium; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008274:Magnesium; D008345:Manganese; D009711:Nucleotides; D010710:Phosphates; D012265:Ribonucleotides; D012964:Sodium; D015032:Zinc
D000227:Adenine Nucleotides; D009711:Nucleotides; D010710:Phosphates; D012265:Ribonucleotides; D001464:Barium; D008345:Manganese; D012964:Sodium; D008274:Magnesium; D015032:Zinc; D002118:Calcium