Determination of the metabolites of bezitramide in urine. I. Acidic metabolite.
Two methylation methods are compared in relation to the determination of low levels (less than microgram/ml) of the acidic metabolite of bezitramide in human urine. It was necessary to use alkali flame ionisation detector, which specifically detects nitrogen-containing compounds. Several difficulties associated with the use of this detector are described.
D000700:Analgesics / Q000652:urine*; D001562:Benzimidazoles / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008722:Methods; D008745:Methylation; D010880:Piperidines / Q000652:urine*
D000700:Analgesics; D001562:Benzimidazoles; D010880:Piperidines; C004461:bezitramide