Study of the priming effect of interferon in L cells. I. The primed interferon response and the kinetics of development of priming.
Interferon was detected one hour earlier, its production followed an enhanced pattern and became resistant to actinomycin D 30 minutes sooner in cultures primed by interferon pretreatment before stimulation by polyriboinosinic-polyribocytidylic acid than in unprimed cultures. The kinetics of development of the primed state was found to be a time and dose dependent phenomenon. The continuous presence of interferon during the pretreatment period was not required for the development of the primed state.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007700:Kinetics; D007739:L Cells / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology
D003609:Dactinomycin; D007372:Interferons; D011070:Poly I-C