[Conformation study of cyclic adenosine-3',5'-monophosphate and some of its derivatives by means of circular dichroism].
Circular dichroism spectra of adenosine and cyclic adenosine-3',5'-monophosphate (cAMP) and their derivatives, having different substituents in 8-position of heterocycle, are studied, cAMP is suggested to have preferable anti-conformation in the solution, while its derivatives with substituents in 8-position of purine base are preferable in sin-conformation. An exception is 8-(beta aminoethylamine-)cAMP, which has an anti-conformation within pH range from 4.5 to 9.5. This is probably due to the formation of intra-molecular ionic bond between cyclophosphate group and aliphatic amino group of 8-position substituent.
D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D000242:Cyclic AMP / Q000031:analogs & derivatives*; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation
D000242:Cyclic AMP
Izuchenie konformatsii tsiklicheskogo adenozin -3',5'-monofosfata i nekotorykh ego proizvodnykh metodom krugovogo dikhroizma