[Role of lipid peroxides in the pathogenesis of arteriosclerosis. Detoxication of lipid peroxides by the glutathione-peroxidase system in the aorta].
In aorta of intact rabbits the high activity of glutathione-peroxidase, which detoxicates lipoperoxides, was observed. In aorta of animals with pronounced experimental atheromatosis the enzyme activity did not distinctly differ from the control values. The animals with high initial content of glutathione-peroxidase in aorta were shown to be less subjected to the impairment in alimentary atherosclerosis.
D000818:Animals; D001011:Aorta / Q000201:enzymology*; D001018:Aortic Diseases / Q000209:etiology* / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism; D001711:Biotransformation; D004036:Diet, Atherogenic; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism*; D011817:Rabbits
D010545:Peroxides; D009249:NADP; D010544:Peroxidases; D005979:Glutathione Peroxidase
Rol' perekiseĭ lipidov v patogenese ateroskleroza. Detoksikatsiia lipoperekiseĭ glutation-peroksidaznoĭ sistemoĭ v aorte