Some clinical pharmacological studies with terfenadine, a new antihistamine drug.
1 A double-blind cross-over trial between placebo, chlorpheniramine, and terfenadine, a new antihistamine drug, was performed in healthy male volunteers to determine and compare their CNS and autonomic effects. 2 Terfenadine and chlorpheniramine were administered orally in therapeutic doses. 3 In objective tests of critical flicker frequency, pursuit rotor, reaction time, salivary volume and pupillary diameter, no statistically significant difference was observed between the treatments. 4 On analogue rating scales, chlorpheniramine produced a statistically significant (P less than 0.05) degree of sedation and impaired concentration as compared to placebo and terfenadine. 5 The results obtained in analogue rating scales were not normally distributed and, therefore, use of non-parametric statistical methods for analysis of such data is strongly advocated.
D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002744:Chlorpheniramine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005425:Flicker Fusion / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D010919:Placebos; D011680:Pupil / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D010880:Piperidines; D010919:Placebos; D002744:Chlorpheniramine