[Excretion of erythropoietin by humans during the production of alkaline or acidic urine (author's transl)].
Marver & Gurney ((1968)Ann.N.Y.Acad.Sci. 149, 570-575) reported that the erythropoietin excretion in two anaemic patients increased 17 and 3.5-fold, respectively, during the production of alkaline urine by the administration of NaHCO3. We have studied the excretion of erythropoietin in 6 persons, following the daily administration of 3.5 g of NH4Cl, which resulted in an average urine pH of 5.9; and following the administration of hexapotassium hexasodium pentacitrate, which increased the urine pH TO 7.5. In the alkaline urine, erythropoietin excretion showed an average, but non-significant, two-fold increase. The increase was significant in only two experimental persons.
D000328:Adult; D000368:Aged; D000643:Ammonium Chloride; D000741:Anemia, Aplastic / Q000652:urine; D002951:Citrates; D004921:Erythropoietin / Q000652:urine*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007674:Kidney Diseases / Q000652:urine; D008297:Male
D002951:Citrates; D000643:Ammonium Chloride; D004921:Erythropoietin
Erythropoetin-Exkretion im alkalischen und sauren Harn beim Menschen