Facilitation of the growth of an allogeneic tumour by suppressor cells in newborn rats.
The intravenous injection of as few as 15 Walker tumour cells into newborn rats consistently resulted in the development of pulmonary metastases and the death of the recipient within 2 weeks. Neither the outcome of tumour cell injection nor the interval until death could be modified by transferring 2 x 10(7) lymphocytes from tumour-immune adult rats to the neonataal hosts. In contrast with this failure to transfer adoptive anti-tumour immune responses to intact recipients, the administration of 350 rad irradiation before transfer of 10(6) immune lymphocytes constantly afforded protection against inoculated tumour cells. The simultaneous transfer of neonatal thymus cells with immune lymphocytes interfered with the establishment of an adoptive response in the irradiated newborn. Intiation of a graft-versus-host response in F1 hybrid neonates by injecting parental strain lymphocytes conferred resistance to tumour growth of the recpient, the magnitude of this effect increasing with the strength of the graft-versus-host reaction.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002279:Carcinoma 256, Walker / Q000276:immunology* / Q000473:pathology; D006087:Graft vs Host Reaction; D006824:Hybridization, Genetic; D007111:Immunity, Cellular / Q000528:radiation effects; D007165:Immunosuppression Therapy; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology*; D011830:Radiation Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000637:transplantation; D014185:Transplantation, Isogeneic