The nature of the renal response to chronic disorders of acid-base equilibrium.
The rate of acid excretion by the kidney appears to be determined by factors regulating the site and the rate of sodium reabsorption, rather than by a homeostatic mechanism that responds to systemic pH. This hypothesis, although unconventional, is supported by much experimental evidence, and it accounts for a wide variety of clinical and physiologic findings that heretofore have been difficult or impossible to explain.
D000042:Absorption; D000137:Acid-Base Imbalance / Q000503:physiopathology* / Q000652:urine; D000138:Acidosis; D000471:Alkalosis / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002412:Cations / Q000378:metabolism; D002908:Chronic Disease; D004285:Dogs; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology; D008903:Minerals; D009399:Nephrons / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D001639:Bicarbonates; D002412:Cations; D008903:Minerals; D014667:Vasopressins; D002245:Carbon Dioxide; D000641:Ammonia; D012964:Sodium