[Does local regional anesthesia exert an immunosuppressive effect?].
Lignocaine in very high doses exhibits immunodepressant properties in vitro. In vivo, in surgical patients submitted to spinal anaesthesia, lymphocyte transformation is diminished for one week. This inhibition is, however, less marked than after general anaesthesia.
D000765:Anesthesia, Conduction; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents; D008012:Lidocaine / Q000276:immunology / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism
D000779:Anesthetics, Local; D007166:Immunosuppressive Agents; D008012:Lidocaine
L'Anesthésie loco-régionale peut-elle exercer une action immuno-dépressive