The pharmacology of flazalone: a new class of anti-inflammatory agent.
The anti-inflammatory activity of flazalone, a unique chemical drug, is described. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits. The pattern of anti-inflammatory activity does not allow one to classify this drug in the usual groups.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001183:Arthus Reaction; D004487:Edema / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D006054:Goldfish; D006084:Graft Rejection; D006087:Graft vs Host Reaction / Q000187:drug effects; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D000893:Anti-Inflammatory Agents; D010880:Piperidines