[Comparison of experimental-psychological and clinical findings on the effect of a test substance (author's transl)].
The results of a pharmacopsychological study on male students high or low in emotional stability are compared to those of a clinical study on neurotic out- and inpatients. These studies examine the effects of diazepam and various doses of a thienodiazepine (Bay g 5653), a drug under investigation. Although the studies are not completely comparable (placebo control missing in the clinical study, not enough information about comparable base line measures) the differences in effects of Bay g 5653 and diazepam on the actual emotional state, as measured by an adjective check list, show a certain amount of correspondence between normal subjects and patients but also considerable discrepancies.
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004644:Emotions / Q000187:drug effects*; D005120:Extraversion, Psychological; D006801:Humans; D008297:Male; D009497:Neurotic Disorders; D010551:Personality; D010919:Placebos
D014151:Anti-Anxiety Agents; D010919:Placebos; D003975:Diazepam
Vergleich experimentalpsychologischer und klinischer Befunde zur Wirkung einer Prüfsubstanz