The objective and timing of drug disposition studies, appendix V. A comparison of the bioavailability of three dosage forms of terfenadine.
Antagonistic effect against histamine-induced wheals was used to evaluate the bioavailability of terfenadine in monkeys. A rapidly dissolving tablet formulation of terfenadine shows essentially identical bioavailability to a liquid suspesion. A less readily dissolving capsule formulation lags considerably in time with regard to availability, and some question remains as to whether the total quantity in the capsule is available.
D000818:Animals; D001682:Biological Availability; D002214:Capsules; D005260:Female; D000882:Haplorhini; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D013535:Suspensions; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D006634:Histamine H1 Antagonists; D013535:Suspensions; D013607:Tablets; D006632:Histamine