[The effect of sympathomimetric drugs on exocrine pancreatic function. Studies in the isolated cat pancreas (author's transl)].
This study reports on effects of beta-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. The injection of these drugs resulted in an increase of pancreatic protein and enzyme secretion, the excretion of calcium into the juice and the rate of volume output were not changed. The enzyme secretion was inhibited by different adrenolytic drugs (phenoxybenzamine, practolol, butoxamine), by tetracain, hemicholinium, and atropine. The pancreatic function of cats pretreated by reserpine or 6-hydroxydopamine was not altered. It is concluded, that beta-sympathomimetic drugs influence the pancreatic protein and enzyme secretion in a cholinergic way. These results are consistent with those of other investigators showing a suppressibility of the isoproterenol-induced pancreatic amylase secretion by atropine.
D000109:Acetylcholine / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002415:Cats; D005280:Fenoterol / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008049:Lipase / Q000378:metabolism; D009921:Metaproterenol / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D013268:Stimulation, Chemical; D013726:Terbutaline / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D011506:Proteins; D005280:Fenoterol; D009921:Metaproterenol; D008049:Lipase; D000681:Amylases; D007545:Isoproterenol; D013726:Terbutaline; D000109:Acetylcholine; D000420:Albuterol; D002118:Calcium
Die Wirkung beta-adrenerger Substanzen auf die exokrine Funktion des Pankreas. Untersuchungen am isoliert perfundierten pankreas der Katze.