Somatostatin--paracrine and neuromodulator peptide in gut and nervous system.
Somatostatin, a tetradecapeptide widely distributed in nervous tissue and gut, has inhibitory effects on secretion and neuromuscular activity. The actions of this peptide probably embrace three types of transmitter-receptor interaction, namely that of a neurotransmitter in the nervous system, that of a hormone in the hypophyseal portal circulation and that of a local (paracrine) effector in gut and pancreas.
D000818:Animals; D004068:Digestive System Physiological Phenomena; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000187:drug effects; D018377:Neurotransmitter Agents; D051381:Rats; D013004:Somatostatin / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D014018:Tissue Distribution
D018377:Neurotransmitter Agents; D013004:Somatostatin