Functional equivalence of iron bound to human transferrin at low pH or high pH.
Human transferrin was labeled with 59Fe at one of its two metal-binding sites (designated A) at pH 6.0. 55Fe was then added to site B at pH 7.5. Both isotopes of iron were taken up in equal proportions by human reticulocytes. These experiments do not support the hypothesis that each binding site of transferrin has a different physiologic function.
D001665:Binding Sites; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism*; D011485:Protein Binding; D012156:Reticulocytes / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism*
D014168:Transferrin; D007501:Iron