Lack of effect of acid-base alterations on growth hormone secretion in man.
In order to study the possible effect of acid-base alterations on growth hormone (GH) secretion in man the exercise-induced GH secretion was compared with the tentative GH release resulting from the acidosis due to hyperlactacidemia after the infusion of fructose. Submaximal exercise on bicycle ergometer resulted in a significant increase of plasma GH and lactate and in acid-base alterations. The infusion of 60 g of fructose during 60 min was without effect on plasma GH level in spite of the increase of serum lactate and slight acid-base alterations. It is concluded that no causal relationship may be found between the acid-base alterations and the increase of plasma GH during physical exercise.
D000328:Adult; D001639:Bicarbonates / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D005632:Fructose / Q000494:pharmacology; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology; D007773:Lactates / Q000097:blood; D008297:Male; D005082:Physical Exertion
D001639:Bicarbonates; D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D005632:Fructose; D013006:Growth Hormone; D005934:Glucagon