Uterine and cardiovascular effects of beta2-selective sympathomimetic drugs administered as an intravenous infusion.
The uterine and cardiovascular effects of fenoterol, hexoprenaline, ritodrine and salbutamol, given as intravenous infusions in equivalent and therapeutic dosages in oxytocin-induced labour, were studied and compared. All the drugs were effective in reducing the uterine activity to less than 30% of the original. The effect on the cardiovascular system was to produce a moderate tachycardia and a widening of the pulse pressure by raising the systolic and decreasing the diastolic blood pressures.
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000420:Albuterol / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage; D006594:Hexoprenaline / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D007751:Labor, Induced; D011247:Pregnancy; D011674:Pulse / Q000187:drug effects*; D012312:Ritodrine / Q000008:administration & dosage; D014590:Uterine Contraction / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D006594:Hexoprenaline; D012312:Ritodrine; D000420:Albuterol