Evidence against the release of prostaglandin-like material from isolated intestinal tissue by pure cholera toxin.
Prostaglandin-like material was released from finely cut guinea-pig ileum or human intestinal mucosa during incubation with Krebs solution. The tissue inactivated some significant change in release of prostaglandin-like material when pure cholera toxin was incubated with guinea-pig ileum or human intestinal mucosa. The work is discussed in relation to the action of cholera toxin in vivo.
D000818:Animals; D001965:Bromides / Q000494:pharmacology; D002771:Cholera; D004088:Dihydroergotoxine / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D008298:Maleates / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D014118:Toxins, Biological / Q000494:pharmacology*
D001965:Bromides; D004983:Ethanolamines; D008298:Maleates; D011453:Prostaglandins; D011458:Prostaglandins E; D014118:Toxins, Biological; D004088:Dihydroergotoxine; D007213:Indomethacin