[Glucose-6-phosphate dehydrogenase deficiency of erythrocytes in the GDR].
34 persons with G-6-PD deficiency were diagnosed, and the pathological enzyme-variants of red blood cells were characterized according to the recommendations of WHO. We conclude from the differing residual G-6-PD-activities in red blood cells of the propositi and the differing reactivity of the enzyme in kinetic and physicochemical characterizations that a multiple variety of rare pathological G-6-PD variants exists in the GDR. Using the estimated enzymeparameters it was not possible in all cases to compare directly the newly demonstrated G-6-PD variants with cases already described in the literature. In addition, the differing combinations of parameters render a classification more difficult.
D004586:Electrophoresis; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005695:Galactosephosphates / Q000378:metabolism; D014644:Genetic Variation; D005859:Germany, East; D005954:Glucosephosphate Dehydrogenase / Q000097:blood* / Q000235:genetics; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000201:enzymology*; D005958:Glucosephosphates / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D013696:Temperature
D005695:Galactosephosphates; D005958:Glucosephosphates; D005954:Glucosephosphate Dehydrogenase
Glukose-6-phosphat-Dehydrogenase-Mangel roter Blutzellen in der DDR.