Low-frequency positive pressure ventilation with extracorporeal carbon dioxide removal (LFPPV-ECCO2R): an experimental study.
We describe a new form of mechanical pulmonary ventilation, low-frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R). In a series of animal studies the rate of mechanical ventilation was 0.66, 1, 2, and 4 min-1 at a tidal volume of 3, 10, and 15 ml kg-1. We were able to maintain normal blood gases and normal lung volumes and lung mechanics even at the lowest ventilator rate with tidal volumes of 10 or 15 ml kg-1. Each experiment lasted 7 hours. Our data suggest a possible new dimension in the management of a difficult patient on mechanical pulmonary ventilation.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy / Q000379:methods; D011175:Positive-Pressure Respiration / Q000379:methods*; D012756:Sheep; D013990:Tidal Volume; D014692:Ventilation-Perfusion Ratio
D002245:Carbon Dioxide; D010100:Oxygen