Bone marrow transplantation in man.
Bone marrow transplantation is emerging as a viable therapeutic approach to a number of diseases that are usually or uniformly fatal. We review here recent experiences in bone marrow transplantation in man at UCLA and in various other institutions throughout the world. We examine marrow transplantation in immunodeficiency diseases, acute leukemia, and aplastic anemia and consider the problems of infection in the transplant recipients. The applications of tissue typing to marrow transplantation and immunologic manipulations, which may influence engraftment and graft-versus-host disease, are also reported.
D000017:ABO Blood-Group System; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D007938:Leukemia / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000150:complications; D011552:Pseudomonas Infections / Q000150:complications; D012008:Recurrence; D012075:Remission, Spontaneous; D013950:Thymus Gland / Q000637:transplantation; D014165:Transfer Factor / Q000627:therapeutic use; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D006649:Histocompatibility Antigens; D014165:Transfer Factor; D003520:Cyclophosphamide