Determination of perazine serum levels by gas liquid chromatography under clinical routine conditions.
A quantitative gas liquid chromatographic method for the determination of serum levels of perazine (10-[3'-(1''-methyl-4''-piperazinyl)-propyl]-phenothiazine) is described. Perazine is used as a neuroleptic drug. The main problem consists in optimizing the chromatographic system. A sensitivity of appr. 60--150 nmol/1 (20--50 microgram/1) serum is achieved. Examples of optimization, analyses with patient samples, and the reproducibility of the results are presented.
D014150:Antipsychotic Agents / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D008832:Microchemistry; D010464:Perazine / Q000097:blood*
D014150:Antipsychotic Agents; D010464:Perazine