The prebiotic synthesis of deoxthymidine oligonucleotides. II. Comparison of condensing agents.
A reaction which oligomerizes nucleotides under possible prebiotic conditions has been characterized. Nucleoside monophosphate in the presence of cyanamide at acid pH condenses to form dithymideine pyrophosphate and phosphodiester bonded compounds. Imidazole compounds and activated precursors such as nucleoside triphosphate are not necessary for this ologomerization reaction which produces primarily cyclic ologonucleotides.
D000469:Alkaline Phosphatase / Q000494:pharmacology; D000588:Amines; D005075:Biological Evolution; D055598:Chemical Phenomena; D002621:Chemistry; D003486:Cyanides; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles; D007700:Kinetics; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000378:metabolism; D009841:Oligonucleotides / Q000138:chemical synthesis*; D000069497:Origin of Life; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D013942:Thymine Nucleotides / Q000138:chemical synthesis* / Q000378:metabolism
D000588:Amines; D003486:Cyanides; D007093:Imidazoles; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D013942:Thymine Nucleotides; D000469:Alkaline Phosphatase; D010727:Phosphoric Diester Hydrolases