[Toxicological characteristics of ampicillin].
Toxocity of ampicillin trihydrate was studied in acute and chronic experiments. It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect. On its inhalation in concentrations of 5 mg/m3 for 4 months, ampicillin induced allergization of albino rats, decreased their immunity. The general toxic effect of the drug was slightly pronounced. Ampicillin in a concentration of 0.1 mg/m3 induced tension of the immunological reactivity of the organism. The maximum permissible concentration (MPC) of ampicillin in the working premises equal to 0.1 mg/m3 is recommended. Mark "Allergen" is necessary.
D000667:Ampicillin / Q000633:toxicity*; D000818:Animals; D004247:DNA / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000097:blood; D004781:Environmental Exposure; D004912:Erythrocytes / Q000187:drug effects; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000097:blood; D007109:Immunity / Q000187:drug effects; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects; D008452:Maximum Allowable Concentration; D051379:Mice; D009504:Neutrophils / Q000187:drug effects; D012313:RNA / Q000097:blood; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D012882:Skin Tests; D013997:Time Factors
D006634:Histamine H1 Antagonists; D012313:RNA; D000667:Ampicillin; D004247:DNA
K toksikologicheskoĭ kharakteristike ampitsillina