Biotin. Its place in evolution.
In the previous article we try to give an explanation for the success of models of enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D005075:Biological Evolution; D001710:Biotin / Q000235:genetics* / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D002384:Catalysis; D004798:Enzymes / Q000235:genetics; D000069497:Origin of Life; D012313:RNA / Q000235:genetics; D013329:Structure-Activity Relationship; D014508:Urea / Q000378:metabolism
D004798:Enzymes; D002245:Carbon Dioxide; D012313:RNA; D001710:Biotin; D014508:Urea; D000103:Acetyl-CoA Carboxylase