Gastrin, antral g cells, and gastric acid in secretagogue-induced and antihistamine-inhibited duodenal ulcers.
In fasting control rats there was continuous basal gastric acid secretion, with a low plasma gastrin and antral G-cells full or immunofluroescent gastrin. After subcutaneous infusion of the gastric secretagogues, pentagastrin + carbachol, there was a six-hour period of gastric hypersecretion, but no change in plasma and G-cell gastrin. Pretreatment with the antihistamine derivative, Pfizer UK-9040, decreased both basal and stimulated acid secretion, whereas plasma gastrin levels increased and the antral G-cells were emptied of gastrin. These results suggest that this antihistamine derivative decreases gastric acid secretion by a direct action on the parietal cells and not by reducing gastrin release from the G-cells. The increased release of gastrin from the G-cells may be secondary to decreased gastric acid production, or more probably by a direct stimulation of the antral G-cells.
D000818:Animals; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000139:chemically induced; D005455:Fluorescent Antibody Technique; D005750:Gastric Juice; D005755:Gastrins / Q000097:blood; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000166:cytology / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology; D013997:Time Factors
D005755:Gastrins; D006635:Histamine H2 Antagonists; D011759:Pyrrolidines; D013876:Thiophenes; C006233:UK-9040; D002217:Carbachol; D010418:Pentagastrin