Lack of effect of methemoglobinemia on the plasma-erythrocyte pH relationship.
A stable and reproducible methemoglobinemia is induced by small concentration of an oxidizing gas (NO). Under such conditions we evidenced that plasma pH (pHe) to erythrocyte pH (pHi) relationship is unchanged. A strong acidity bound to the changes of NO in water occurs. But we may conclude that the buffer capacity of erythrocyte is not modified by the oxydation of ferro into ferrihemoglobin within the erythrocyte.
D000136:Acid-Base Equilibrium; D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008708:Methemoglobinemia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D009569:Nitric Oxide / Q000494:pharmacology; D051381:Rats
D009569:Nitric Oxide