Increase by calcium in production of interferon by L929 cells induced with polyriboinosinate-polyribocytidylate complex.
Calcium chloride (5 to 20 mM) potentiated interferon production induced by rIn:rCn in L929 mouse fibroblasts up to a thousand-fold. Higher concentrations of calcium (20 to 65 mM) mixed with rIn:rCn were associated with increased cytotoxicity and a more acidic medium, but were effective in enhancing interferon production if preparations were adjusted to a uniform pH. Although calcium increased cellular binding of 3H-rCn:rIn, only a partial correlation between binding and interferon production was observed.
D002122:Calcium Chloride / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells / Q000187:drug effects* / Q000378:metabolism; D011070:Poly I-C / Q000378:metabolism / Q000494:pharmacology*; D013268:Stimulation, Chemical
D007372:Interferons; D002122:Calcium Chloride; D011070:Poly I-C