Pharmacokinetic studies on ditazole, a novel inhibitor of platelet aggregation.
The distribution of ditazole in blood and tissues of rats was determined by a simple GLC technique. Ditazole, after intravenous injection in rats (20 mg/kg), entered preferentially into the brain, the liver, and the heart in decreasing order. In the epididymal adipose tissue, the drug was present only in small amounts. Ditazole disappeared from the rat organs 4 hr after the treatment. The apparent ditazole half-life in rat blood was 41 min, the volume of distribution was 2.068 liters/kg, and the body clearance was 0.0345 liter/kg/min.
D000818:Animals; D002849:Chromatography, Gas; D003864:Depression, Chemical; D007700:Kinetics; D008297:Male; D010080:Oxazoles / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D014018:Tissue Distribution
D010080:Oxazoles