Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension.
A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, controlled the patient's blood pressure and was associated with reduction in total urinary catecholamine excretion. Norepinephrine content of the tumor and uninvolved adrenal gland removal at surgery was reduced. These findings confirm that alpha methyl tyrosine inhibited in vivo synthesis of catecholamines.
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000378:metabolism; D002395:Catecholamines / Q000652:urine; D002648:Child; D004338:Drug Combinations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology / Q000627:therapeutic use*; D010643:Phenoxybenzamine / Q000627:therapeutic use; D010673:Pheochromocytoma / Q000150:complications* / Q000378:metabolism; D011433:Propranolol / Q000627:therapeutic use; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D002395:Catecholamines; D004338:Drug Combinations; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D011433:Propranolol; D014446:Tyrosine 3-Monooxygenase