[Pharmacological study of para-aminoclonidine, an alpha sympathomimetic].
Para-aminoclonidine is a more potent alpha-adrenergic agent than clonidine; in vitro on Rat aorta it is 150 times more active than NE, in vivo on pithed Rat it is still twice as active. The hypotensive action of paraaminoclondine is only manifested when given intraventricularly. In the conscious Rat, it has a diuretic action when given per os. Following IV injection in the anaesthetized Dog, the para-aminoclonidine induces an essentially hydric diuresis which is independet of its hypertensive action.
D000316:Adrenergic alpha-Agonists; D000818:Animals; D000959:Antihypertensive Agents; D001011:Aorta / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004232:Diuretics; D004285:Dogs; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats
D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D004232:Diuretics; D003000:Clonidine; D009638:Norepinephrine
Etude pharmacologique de la para-aminoclonidine, sympathomimétique alpha.