[Effect of corticotropin on functional and metabolic processes in muscles].
Changes of excitability, contractility, temperature, activity of oxydation-reduction enzymes, pyridine nucleotides, and of free fatty acids were studied in m. m. gastrocnemii of rabbits and rats during activity, after administration of 1 unit per 100 g of corticotropin (ACTH). Within 30 min after administration, the ACTH did not alter the excitability of a neural-muscular system but increased its efficiency by means of stimulation of the free fatty acids usage. Besides, the ACTH elicits no regular changes of the oxydation--reduction enzymes activity during a short-lasting muscular activity. Its regulating effect on the metabolic processes in muscles is realised at the level of anaerobic processes.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D013229:Stearic Acids / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D013229:Stearic Acids; D010725:Phosphocreatine; D009243:NAD; D009249:NADP; D000255:Adenosine Triphosphate; D000324:Adrenocorticotropic Hormone; D006003:Glycogen; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV
Deĭstvie kortikotropina na funktsional'nye i metabolicheskie protsessy v myshtsakh.