[Variation of plasma amino acids in severe hepatitis with encephalopathy 10 cases].
Plasma levels of different amino acids were observed in 10 patients with severe hepatitis, 9 viral in origin and 1 toxic, over the course of the disease. There would appear to be a close relationship between the onset of encephalopathy and the appearance of a particular pattern in plasma amino acid equilibrium, characterised by a significant fall in the molar ratio existing between ramified amino acids (valine, leucine, isoleucine) and aromatic amino acids (phenylalanine and tyrosine). The role of these disturbances in the physiopathology of the encephalopathy and their effects on the synthesis of normal neurotransmitters and the intracerebral accumulation of false neurotransmitters is discussed.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D001667:Binding, Competitive; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006505:Hepatitis / Q000097:blood*; D006801:Humans; D006900:Hydroxylation; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism; D010649:Phenylalanine / Q000097:blood; D014443:Tyrosine / Q000097:blood; D014633:Valine / Q000097:blood
D000596:Amino Acids; D018377:Neurotransmitter Agents; D007532:Isoleucine; D014443:Tyrosine; D010649:Phenylalanine; D007930:Leucine; D014633:Valine
Variation des acides aminés plasmatiques au cours des hépatites graves avec encéphalopathie. 10 observations