The amphetamine-induced inhibition of dopamine biosynthesis in rat striatum.
The dopamine biosynthetic machinery of intact synaptosomes of rat striatum showed a 5-fold increase in development from 3-day-old neonates to adults, and it was fully developed between 2-3 weeks after birth. Concurring with this development was the appearance 2 weeks after birth of a regulatory mechanism(s) through which amphetamine in vivo induced an inhibition of dopamine biosynthesis. The inhibition was not appreciably reversed when haloperidol, in addition to amphetamine, was administered.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D003342:Corpus Striatum / Q000201:enzymology / Q000378:metabolism*; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000096:biosynthesis*; D006220:Haloperidol / Q000494:pharmacology; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D006220:Haloperidol; D003913:Dextroamphetamine; D004298:Dopamine