Histopathology of hepatic acute graft-versus-host disease in the dog. A double blind study confirms the specificity of small bile duct lesions.
To test the association of small bile duct destructive lesions in the liver with acute graft-versus-host disease,  a blind (coded) histological study was done comparing liver tissue from three groups of dogs given 1,200 R of total-body irradiation: one not given marrow infusions after irradiation, another given autologous hemopoietic grafts, and a third given marrow grafts from DLA-nonidentical unrelated donors. The dogs with unrelated grafts all developed graft-versus-host disease, and their liver histology was distinguished from that of the dogs in the other two groups by three findings: (1) extensive small bile ductule necrosis and atypia; (2) infiltrates of mononuclear cells around and in ductules; and (3) individual hepatocyte necrosis scattered throughout the lobules. Thus, bile duct lesions appear to be a good marker for assessing the presence and severity of hepatic graft-versus-host disease in dogs.
D000818:Animals; D016026:Bone Marrow Transplantation; D004285:Dogs; D004311:Double-Blind Method; D006087:Graft vs Host Reaction; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D014182:Transplantation, Autologous