[In vitro effect of psychopharmacologic drugs on the embryonic brain tissue of the fetuses of schizophrenic mothers].
The author studied the influence on the adaptation of the nervous tissue explantations from 25 fetuses of schizophrenic mothers and a similar amount of fetuses from normal women (embryonal development--7-12 weeks) during the initial period of explantation in vitro (5-6 days) with 10 psychopharmacological preparations (aminasine, majeptile, stelasine, triphtasine, tesercin, theralen, haloperidol, eglonyl, mellipramin, seduxen). Their final concentration in a nourishing medium was approximately the same as in the blood of schizophrenic patients, treated by phenothiasine preparations. The adaptation of the fetus pervous tissue from schizophrenic mothers differed from the corresponding reaction of fetus brain explantation from normal women. There was a tendency to a higher stability of experimental cultures. However, there were differences depending upon the character of introduced drugs.
D000928:Antidepressive Agents / Q000633:toxicity*; D014150:Antipsychotic Agents / Q000633:toxicity; D001921:Brain / Q000196:embryology*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D009924:Organ Culture Techniques; D010640:Phenothiazines; D011247:Pregnancy; D012559:Schizophrenia / Q000235:genetics*; D014149:Tranquilizing Agents / Q000633:toxicity*
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D010640:Phenothiazines; D014149:Tranquilizing Agents
Osobennosti vliianiia in vitro psikhofarmakologicheskikh sredstv na émbrional'nuiu tkan' mozga plodov bol'nykh shizofrenie matereĭ.