Structural evidence for gene duplication in the evolution of the acid proteases.
X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular twofold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for evolution by gene duplication, divergence and gene fusion is presented.
D000595:Amino Acid Sequence; D001665:Binding Sites; D005075:Biological Evolution; D005796:Genes; D006863:Hydrogen-Ion Concentration; D010447:Peptide Hydrolases / Q000235:genetics*; D011487:Protein Conformation
D010447:Peptide Hydrolases