Evaluation of the antibiotic effect of treatment of maxillary sinusitis.
As the effect of antibiotic treatment of maxillary sinusitis has been questioned, the elimination of bacteria from sinus secretions was studied during antibiotic treatment. Penicillin V, azidocillin, tetracycline or doxycycline was administered to 54 patients with maxillary sinusitis. Samples of sinus secretion were aspirated both before treatment and 2-3 days after the onset of treatment. When the antibiotic concentration was below the upper limit of MIC for sensitivity group 1, bacterial growth was present in practically all samples. When the antibiotic concentration equalled or was above this limit, there was no bacterial growth in about half of the samples. A prerequisite for antibiotic effect--elimination of bacteria--is that the antibiotic concentration is well above the MIC of the bacteria at the site of infection. The choice between bactericidal or bacteriostatic antibiotics appeared unimportant. Bacterial survival in the maxillary sinus despite a high antibiotic concentration in the sinus illustrates that MIC values determined in the laboratory do not always mirror the sensitivity of bacteria to antibiotics in vivo.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008443:Maxillary Sinus / Q000382:microbiology; D010400:Penicillin G / Q000031:analogs & derivatives / Q000627:therapeutic use; D010404:Penicillin V / Q000627:therapeutic use; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology; D013291:Streptococcus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013752:Tetracycline / Q000627:therapeutic use; D013997:Time Factors
D000900:Anti-Bacterial Agents; D013752:Tetracycline; D004318:Doxycycline; D010400:Penicillin G; D010404:Penicillin V