[Effect of amisyl and spasmolytin on the blood supply and oxygen metabolism of the brain].
The effect of benactyzine and spasmolytin adiphenine on the blood circulation in the oxygen consumption by the brain were investigated in experiments on dogs. The resulting data point to a biphasic action of benacyzine and spasmolytin on the blood supply of the brain (after a short-lived increase of the blood flow a clearcut decline of it is noted). The oxygen intake from the blood varies irregularly. In chlorophos-poisoned dogs the oxygen absorption by the brain changes under the effect of benactyzine and rises after administration of spasmolytin. The cerebral circulation then changes non-uniformly under the effect of benactyzine, while following spasmolytin injections it dicreases in the majority of experiments.
D000042:Absorption; D000208:Acute Disease; D000818:Animals; D001535:Benactyzine / Q000494:pharmacology*; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004158:Diphenylacetic Acids / Q000494:pharmacology*; D004285:Dogs; D010101:Oxygen Consumption / Q000187:drug effects*; D014236:Trichlorfon / Q000506:poisoning
D004158:Diphenylacetic Acids; D001535:Benactyzine; D014236:Trichlorfon
Vliianie amizila i spazmolitina na krovosnabzhenie i kislorodnyĭ metabolizm golovnogo mozga.