Electrophysiologically determined quinidine-like actions of a beta-adrenergic blocking agent, 1-(7-indenyloxy)-3-isopropylaminopropane-2-ol hydrochloride (YB-2).
Since 1-(7-indenyloxy)-3-isopropylaminopropane-2-ol hydrochloride (YB-2) has been reported to be a potent beta-adrenergic blocking agent with antiarrhythmic effects, the electrophysiological effects of this compound on guinea-pig and canine heart muscle were examined. YB-2 was found to have typical quinidine-like actions such as decrease in rate of rise of the action potential, prolongation of refractory period and decrease in conduction velocity.
D000200:Action Potentials / Q000187:drug effects; D000319:Adrenergic beta-Antagonists; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology*; D011802:Quinidine / Q000494:pharmacology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D007192:Indenes; D011412:Propanolamines; C002989:indenolol; D011802:Quinidine