[Androgen participation in realizing the action of hydrocortisone and insulin on tyrosine-alpha-ketoglutarate transaminase synthesis in rat liver mitochondria].
Castration of adult rats did not distinctly alter the tyrosine alpha-ketoglutarate transaminase activity in liver tissue mitochondria. Administration of hydrocortisone caused the more pronounced increased of the tyrosine alpha-ketoglutarate transaminae activity in liver tissue mitochondria of young males as compared with the adult intact rats. Castration of adult rats did no alter stimulating effect of the glucocorticoid. Insulin decreased the stimulating effect of hydrocortisone on the synthesis of the synthesis of the enzyme in liver tissue mitochondria of young and adult castrated males. Insulin decreased the effect of hydrocortisone in adult castrated rats, provided with excess of testosterone propionate and did not change the effect in adul intact animals.
D000367:Age Factors; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002369:Castration; D004789:Enzyme Activation / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D000728:Androgens; D007328:Insulin; D013739:Testosterone; D014444:Tyrosine Transaminase; D006854:Hydrocortisone
Ob uchastii androgenov v realizatsii deĭstviia gidrokortizona i insulina na sintez tirozin-al'fa-ketogliutarattransaminazy v mitokhondiiakh pecheni krys