Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine.
Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D005753:Gastric Mucosa / Q000187:drug effects; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D006146:Guanidines / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D007052:Ibuprofen / Q000009:adverse effects; D007093:Imidazoles / Q000627:therapeutic use; D007660:Ketoprofen / Q000009:adverse effects; D008297:Male; D008785:Metiamide / Q000627:therapeutic use*; D009288:Naproxen / Q000009:adverse effects; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D008785:Metiamide; D009288:Naproxen; D007660:Ketoprofen; D013890:Thiourea; D001241:Aspirin; D007052:Ibuprofen