Glutamine synthetase of Klebsiella aerogenes: properties of glnD mutants lacking uridylyltransferase.
The glnD mutation of Klebsiella aerogenes is cotransducible by phage P1 with pan (requirement for pantothenate) and leads to a loss of uridylytransferase and uridylyl-removing enzyme, components of the glutamine synthetase adenylylation system. This defect results in an inability to deadenylylate glutamine synthetase rapidly and in a requirement for glutamine for normal growth. Suppression of the glnD mutation are located at the glutamine synthetase structural gene glnA.
D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D005796:Genes; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D006638:Histidine Ammonia-Lyase / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics*; D009154:Mutation; D009713:Nucleotidyltransferases / Q000378:metabolism*; D013489:Suppression, Genetic; D014161:Transduction, Genetic; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase / Q000378:metabolism*
D009713:Nucleotidyltransferases; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase; D006638:Histidine Ammonia-Lyase; D005974:Glutamate-Ammonia Ligase