[Value of the "gastric chamber", new technic performed ex vivo, for the study of the gastric mucosa of the rat].
The "gastric chamber" technique, performed in the anaesthetised rat, enables the study of gastric mucosal fragility induced by doses of phenylbutazone, which do not themselves cause ulceration or exulceration. The perfusion of buffered solution at pH 2-8 into the gastric chamber shows that prior oral administration of phenylbutazone 50 mg/kg increases the fragility of the mucosa. The optimal delay separating this administration from the time of experimentation is 6 hours. The effects seen are essentially vascular disorders.
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006863:Hydrogen-Ion Concentration; D008297:Male; D010477:Perfusion; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D013997:Time Factors; D014652:Vascular Diseases / Q000139:chemically induced
D010653:Phenylbutazone
Intért de la "chambre gastrique", nouvelle technique réalisée ex vivo, pour l'étude de la fragilisation de la muqueuse gastrique du rat