Necrotizing arteritis in acute poststreptococcal glomerulonephritis: report of a recovered case.
A patient with biopsy documented acute poststreptococcal glomerulonephritis and arteritis recovered completely with supportive therapy. Illness was preceded by group A streptococcal pharyngitis. At the time of presentation, serum creatinine concentration was 11.5 mg/dl. Serum cryoglobulins containing IgG and C3 were present. The first biopsy, performed during the acute illness, contained glomeruli with typical features of acute PSGN. Medium-sized arteries had extensive necrosis and leukocytic infiltration, and contained IgG, C3, and fibrin. Glomerular filtration rate returned to normal within three weeks; proteinuria cleared by three months, and microscopic hematuria by 11 months. Renal biopsy one year later showed minimal mesangial hypercellularity and no arteritis.
D000208:Acute Disease; D000293:Adolescent; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D003450:Cryoglobulins / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D010488:Polyarteritis Nodosa / Q000276:immunology* / Q000473:pathology; D013290:Streptococcal Infections / Q000276:immunology* / Q000473:pathology; D013297:Streptococcus pyogenes
D003176:Complement C3; D003450:Cryoglobulins; D007070:Immunoglobulin A; D007074:Immunoglobulin G