Growth of a heterologous tumor cell line in neonatal rats with graft-versus-host disease.
The ability of a hamster tumor cell line (T20) to grow and exhibit type H virus particles was significantly enhanced in neonatal DA rats with graft-versus-host disease (GVHD). Tumor growth peaked on days 4 and 7 in control littermates receiving adult syngeneic cells or no cells at birth, respectively, and then subsequently disappeared. However, tumor nodules in animals with GVHD became significantly larger than those in controls by day 7 and continued to grow until death. In addition, a marked plasma cell infiltration was noticed in such rapidly growing tumors from animals with GVHD only. In the light of previous studies, evidence is discussed for an environment within animals with GVHD conducive for tumor cell growth because of a depletion of T-cell areas within their tissues.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D002455:Cell Division; D002460:Cell Line; D005260:Female; D006087:Graft vs Host Reaction; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D009929:Organ Size; D010950:Plasma Cells / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000473:pathology; D013997:Time Factors; D014183:Transplantation, Heterologous