Suppression of experimental allergic encephalomyelitis in guinea-pigs with poly-L-lysine.
Poly-L-lysin (PLL) given subcutaneously in a dose of 3 mg/day suppresses experimental allergic encephalomyelitis in guinea-pigs. The suppressive effect of PLL can still be demonstrated when administration is begun 8 days post-immunization. The effect is disease- and species-specific since PLL (3 mg/day) does not suppress experimental allergic orchitis in guinea-pigs, nor does it suppress EAE in rats (1-5 mg/day). PLL (0-2 mg/day) does not decrease the severity of graft-versus-host disease (GVH) in mice as judged by the spleen/body weight assay.
D000818:Animals; D001835:Body Weight; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006087:Graft vs Host Reaction; D006168:Guinea Pigs; D007114:Immunization; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009920:Orchitis / Q000276:immunology / Q000517:prevention & control; D010455:Peptides / Q000627:therapeutic use*; D011107:Polylysine / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D007166:Immunosuppressive Agents; D010455:Peptides; D011107:Polylysine