[Increase in the oxygen available to the cerebral cortex after the administration of carbonic anhydrase inhibitors].
Oxygen tension (pO2) in cerebral cortex was measured by polarographic method in unanesthetized rabbits. Intravenous administration (25 mg/kg) of carbonic anhydrase inhibitors (acetazolamide, methazolamide, dichlorphenamide, sulthiame) induced an early important rise of cortical p O2, which is not dependent on increase of p O2 and p CO2 and decrease of pH in arterial blood. High dosage of acetazolamide (250 mg/kg) produced the same effect and did not suppress the increase of cortical p O2 under air-CO2 inhalation. This result suggests that CO2 might act specifically upon cerebral vessels.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011817:Rabbits; D012119:Respiration
D002257:Carbonic Anhydrase Inhibitors; D002245:Carbon Dioxide; D010100:Oxygen
Accroissement de l'oxygène disponible du cortex cérébral par administration d'inhibiteurs de l'anhydrase carbonique