Computer evaluation of antiviral activities of some thiosemicarbazones in experiments in vivo.
A new mathematical method based on 3-, 4- or 6-point parallel-line assays was applied for working out a computer programme used to evaluate the activity of some new isatin-beta-thiosemicarbazone derivatives against vaccinia virus, studied in vivo.
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage; D055598:Chemical Phenomena; D002621:Chemistry; D003201:Computers; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D008297:Male; D008720:Methisazone / Q000494:pharmacology; D051379:Mice; D013882:Thiosemicarbazones / Q000008:administration & dosage / Q000494:pharmacology*; D014615:Vaccinia / Q000517:prevention & control; D014616:Vaccinia virus / Q000187:drug effects*
D000998:Antiviral Agents; D013882:Thiosemicarbazones; D008720:Methisazone