[Ways to optimize the technological process of oleandomycin reextraction].
Dependence of the oleandomycin distribution coefficient on pH of the acqueous phase and temperature in the system of butylacetate extract-water acidified with orthophosphoric acid was studied. With a purpose of intensification of the process of oleandomycin reextraction, decreasing the antibiotic inactivation and evaporation of the organic solvent it was proposed to perfom oleandomycin extraction at pH 4.0--5.0 accompanied by simultaneous decreasing of the temperature.
D000085:Acetates / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D009827:Oleandomycin / Q000302:isolation & purification*; D012996:Solutions; D013678:Technology, Pharmaceutical; D013696:Temperature; D013997:Time Factors
D000085:Acetates; D012996:Solutions; D009827:Oleandomycin
O putiakh optimizatsii tekhnologicheskogo protsessa reékstraktsii oleandomitsina.