The effect of progressive hypoxia on respiration in the toad Bufo marinus.
1. As Bufo marinus became progressively hypoxic over a period of 90 min, there was a rise in arterial pH, presumably brought about by hyperventilation. The alkalosis gradually disappeared when oxygen levels became very low. It is suggested that this is the result of a respiratory or a metabolic pH adjustment, or both. 2. Hypoxic animals developed a characteristic breathing pattern in which discrete periods of lung ventilations alternated with buccal oscillations or respiratory pauses. 3. A pronounced bradycardia was associated with the concomitant decline of inspired and arterial PO2. 4. Although respiratory rates were greater than normal resting values in the initial stages of post-hypoxia, the pre-exposure breathing pattern was quickly restored. Following recovery from bradycardia (60 min), the breathing rates, arterial blood gases and pHa returned to normal within 30 min.
D000818:Animals; D001784:Blood Gas Analysis; D002024:Bufo marinus / Q000502:physiology*; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000503:physiopathology*; D012119:Respiration