Cyanide intoxication in the rat: physiological and neuropathological aspects.
Sodium cyanide was given to rats by intravenous infusion at a rate that would avert apnoea (the first sign of overdosage) in the majority. There was full physiological monitoring in a group under anaesthesia and more limited monitoring in an unanaesthetized group. White matter was damaged in six animals and grey matter additionally in only one. It was concluded that cyanide can damage neurones only through the medium of secondary effects on circulation and respiration.
D000818:Animals; D001049:Apnea / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D003337:Corpus Callosum / Q000473:pathology; D003486:Cyanides / Q000506:poisoning*; D004569:Electroencephalography; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008297:Male; D009186:Myelin Sheath / Q000473:pathology; D010100:Oxygen / Q000097:blood; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D013746:Tetany / Q000139:chemically induced; D013788:Thalamus / Q000473:pathology
D003486:Cyanides; D002245:Carbon Dioxide; D010100:Oxygen