Tetrazole analogs of phenylalanine derivatives as tyrosine hydroxylase inhibitors.
Eight new tetrazole analogs of phenylalanine derivatives in which the carboxyl group was replaced by a tetrazole ring were synthesized. At a concentration of 2.5 time 10(-5) M, each compound exhibited greater than 50% inhibition of tyrosine hydroxylase activity.
D000818:Animals; D002417:Cattle; D066298:In Vitro Techniques; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013777:Tetrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*
D013777:Tetrazoles; D010649:Phenylalanine; D014446:Tyrosine 3-Monooxygenase