A kallikrein-specific inhibitor in rat kidney tubules.
A kallikrein inhibitor was found in tubules of the rat kidney and purified by chromatography on Sephadex G-100. The molecular weight of the inhibitor, estimated by gel filtration and dodecylsulfate electrophoresis, is about 4700. It inhibits the following kallikreins: porcine submanidbular and pancreatic kallikrein, rat kidney and urine kallikrein, and human urine and plasma kallikrein. An inhibition of bovine trypsin was not observed.
D000818:Animals; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007610:Kallikreins / Q000037:antagonists & inhibitors*; D007684:Kidney Tubules / Q000032:analysis*; D008970:Molecular Weight; D051381:Rats; D013552:Swine
D007610:Kallikreins