The gamma-carboxy glutamic acid content of human and bovine prothrombin following warfarin treatment.
A form of prothrombin induced by Warfarin therapy, has been isolated which is adsorbed onto insoluble barium salts, but has a reduced biological activity. This protein contains, on average, seven out of a possible ten gamma-carboxy glutamic acid residues. A second form of prothrombin is also described, which is not adsorbed into barium slats, and has less than 1% the activity of the normal protein, contains only four gamma-carboxy glutamic acid residues. The significance of these results is discussed.
D000595:Amino Acid Sequence; D000818:Animals; D001464:Barium; D002417:Cattle; D005971:Glutamates / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010446:Peptide Fragments; D011516:Prothrombin / Q000502:physiology; D013045:Species Specificity; D014859:Warfarin
D005971:Glutamates; D010446:Peptide Fragments; D001464:Barium; D014859:Warfarin; D011516:Prothrombin