Fosfomycin: Absorption and excretion.
Summarized results of absorption and excretion of fosfomycin after oral and intravenous administration obtained from hospitals and institutions in Japan are reported. Fosfomycin was rapidly absorbed and excreted from the urine once it was distributed, the 6-hour urinary recovery reaching about 20% in the case of oral administration and 90% in the case of intravenous injection. These phenomena are almost the same as those previously published. Higher concentration was noticed in the kidney, which gradually decreased according to the fall of the blood level. The blood level reached its maximum of about 3 mug/ml after oral administration to adults at a dose of 500 mg.
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001639:Bicarbonates / Q000494:pharmacology; D005578:Fosfomycin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001639:Bicarbonates; D005578:Fosfomycin