[Age related effects of furosemide in the rat].
Furosemide (6 mg/kg i.p.) increases the renal excretion of water, osmotic active substances, sodium and chloride in 5 to 33 day old rats more than in adults. The dose-response-relations are the same in rats of all age groups: 6 mg/kg of furosemide i.p. are very effective, an increase in dose to 30-60 mg/kg i.p. is not followed by a significantly higher efficacy. The increase in the renal excretion of potassium, hydrogen ions, ammonium and hydrogen carbonate by furosemide is also small in young rats.
D000367:Age Factors; D000641:Ammonia / Q000652:urine; D000818:Animals; D002254:Carbonates / Q000652:urine; D002712:Chlorides / Q000652:urine; D005665:Furosemide / Q000494:pharmacology* / Q000652:urine; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine
D002254:Carbonates; D002712:Chlorides; D000641:Ammonia; D005665:Furosemide; D012964:Sodium; D011188:Potassium
Altersabhängige Wirkungen von Furosemid bei Ratten