[Pharmacokinetics of the new Soviet, tritium-labelled, antihistamine preparation, phencarol].
As evidenced no less than 45 per cent of tritium-labelled antihistaminic drug phencarol (quinuclidine-3-diphenylcarbinol hydrochloride) introduced intragastrically to rats is absorbed. The maximal radioactivity in various organs is reached in 1--3 hours, with high specific radioactivity being recorded in the lungs and liver and low--in the brain. The drug or radioactive products of its tranformation are eliminated largely via the gastrointestinal tract and kidneys.
D000818:Animals; D001559:Benzhydryl Compounds / Q000378:metabolism / Q000494:pharmacology; D001702:Biopharmaceutics; D006634:Histamine H1 Antagonists / Q000378:metabolism / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D011812:Quinuclidines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014316:Tritium
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D011812:Quinuclidines; D014316:Tritium; C014742:quifenadine
Farmakokinetika novogo otechestvennogo protivogistaminnogo preparata fenkarola, mechennogo tritiem.