[Experimental study of a gentamicin aerosol].
The study of gentamicin aerosol showed its relative innocuousness: it did not inhibit the growth and development of young animals, did not induce pathological changes in the upper respiratory tract, kidneys, liver, heart and spleen on its prolonged use. Pathohistological examination revealed slight irritating effect of the gentamicin aerosol in the lungs after its use in a dose of 8 or 25 mg/kg for 6 weeks. A procedure for investigating the effect of the aerosol on the activity of the trachea ciliated epithelium of warm blooded animals was developed. The gentamicin aerosols prepared from solutions of different concentrations (1 to 50 mg/ml) induced ingibition of the ciliated epithelium function at average from 15 to 35 per cent which was associated with the solution acidity (pH 4.54 to 4.82). Such a decrease in the function of the ciliated epithelium due to the antibiotic aerosol use was a factor prolonging the antibiotic retention time in the respiratory organs. It was found that aqueous solutions of drugs used for inhalation, such as ephedrin, euphelin, dimedrol, N-acetyl-L-cystein and others had no effect on the activity of gentamicin and may be used with it in a form of aerosols.
D000336:Aerosols; D000818:Animals; D001001:Anura; D002415:Cats; D002923:Cilia / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004947:Esophagus / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010592:Pharmaceutic Aids / Q000494:pharmacology; D012996:Solutions; D013997:Time Factors; D014132:Trachea / Q000187:drug effects
D000336:Aerosols; D005839:Gentamicins; D010592:Pharmaceutic Aids; D012996:Solutions
Eksperimental'noe izuchenie aérozolia gentamitsina