[The effect of etilefrine and dihydroergotamine on sympathetic nervous system activity when standing up (author's transl)].
Systolic blood pressure, heart rate and concentrations of adrenaline, noradrenaline and dopamine as well as plasma dopamine-beta-hydroxylase (DBH) were measured in 22 subjects in recumbency and on standing up. Six subjects each had previously been given intravenously dihydroergotamine (0.5 mg) or etilefrine (0.25 mg/min) or a placebo. It was demonstrated that orthostasis leads to an increased activity of the sympathetic nervous system and the adrenal system. After administration of dihydroergotamine there was a diminished reaction of the sympathetic nervous system with an increase of venous tone which counteracted the decrease in cardiac output. Etilefrine, on the other hand, inhibited the sympatho-adrenal reaction on orthostasis and decreased the liberation of adrenaline. It acts directly via stimulation of alpha-and beta-receptors and is thus predominantly indicated if there is insufficient response of the baroreceptor reflex at its efferent limb.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D004087:Dihydroergotamine / Q000494:pharmacology* / Q000627:therapeutic use; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005039:Etilefrine / Q000494:pharmacology* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy; D009638:Norepinephrine / Q000097:blood; D010656:Phenylephrine / Q000031:analogs & derivatives*; D010919:Placebos; D011187:Posture; D013564:Sympathetic Nervous System / Q000187:drug effects*
D010919:Placebos; D010656:Phenylephrine; D004087:Dihydroergotamine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine; D005039:Etilefrine
Wirkung von Etilefrin und Dihydroergotamin auf die Sympathicusaktivität bei Orthostase.