[Effect of 3-acetylpyridine on the functional activity of the adrenal cortex].
A reduction of blood corticosteroid content was observed in rats blood after the administration of 3-acetylpyridine. The rats given ACTH after 3-acetylpyridine showed a lesser elevation of corticosteroids in the blood and adrenal gland tissue than the intact animals; 3-acetylpyridine diminished the activity of dehydrogenase glucose-6-phosphate in the adrenal glands. The authors suggested that the action of acetylpyridine was realized at the adrenal gland level and consisted in inhibition of the NADP-H2 generation in the dehydrogenase systems.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors; D000818:Animals; D003864:Depression, Chemical; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008297:Male; D009249:NADP / Q000096:biosynthesis; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D000305:Adrenal Cortex Hormones; D011725:Pyridines; D009249:NADP; D000324:Adrenocorticotropic Hormone; D005954:Glucosephosphate Dehydrogenase
Vliianie 3-atsetilpiridina na funktsional'nuiu aktivnost' kory nadpochechnikov