[The sympathetic nervous system inhibition in the antihypertensive effect of beta-blockers (author's transl)].
The decrease of sympathetic activity by the beta-blocking drug, as demonstrated by the decreased electric activity of the splanchnic nerve and by the decreased urinary catecholamine reponse to tilt as well as by the decreased levels of plasma dopamine beta-hydroxylase exists not only in hypertension with elevated PRA but also in hypertension with normal or low PRA. In these latter cases the antihypertensive effect is better explained by the decrease in the sympathetic nervous system activity than by the decrease of PRA. This effect seems to be indirect and probably, as suggested by Lewis, as a result of damping sensory input to the central nervous system from the heart, whose capacity to respond to exercice and stress is blunted by beta-adreno-receptor blockade.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002395:Catecholamines / Q000652:urine; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D011187:Posture; D012083:Renin / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D013153:Splanchnic Nerves / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002395:Catecholamines; D004299:Dopamine beta-Hydroxylase; D012083:Renin
Action antihypertensive des bêtabloqueurs: rôle de l'inhibition du système nerveux sympathique.