Pharmacology of lorazepam.
Lorazepam reduced conflict behavior in rats and monkeys, inhibited pentylenetetrazol- and electroshock-induced convulsions, suppressed footshock-induced fighting behavior, and prevented morphine-induced stimulation in mice at lower doses than other benzodiazepines tested. This behavioral profile suggests that lorazepam will be an active anti-anxiety agent in man at low doses.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D003216:Conditioning, Operant / Q000187:drug effects; D004056:Differential Threshold; D004193:Discrimination Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D000882:Haplorhini; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012018:Reflex / Q000187:drug effects; D012453:Saimiri; D012640:Seizures / Q000209:etiology / Q000517:prevention & control
D014151:Anti-Anxiety Agents; D008140:Lorazepam