Pharmacology and therapeutic use of antihistamines.
The classes of antihistaminic agents, their pharmacology and therapeutic uses, adverse effects, drug interactions, toxic overdoses and abuse are reviewed. It is concluded that antihistamines are valuable drugs for treating a number of conditions and diseases (e.g. allergic rhinitis, motion sickness and parkinsonism), but proof of efficacy has not been established for the treatment of cardiac arrhythmias, peptic ulcers, insomnia and headaches. Because responses to antihistamines may vary, titration of each patient's dose is recommended.
D000588:Amines / Q000494:pharmacology; D000707:Anaphylaxis / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy; D004338:Drug Combinations; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology; D005029:Ethylenediamines / Q000494:pharmacology; D006261:Headache / Q000188:drug therapy; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000145:classification / Q000494:pharmacology / Q000506:poisoning / Q000627:therapeutic use; D006801:Humans; D009041:Motion Sickness / Q000188:drug therapy; D010300:Parkinson Disease / Q000188:drug therapy; D010437:Peptic Ulcer / Q000188:drug therapy; D010640:Phenothiazines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy; D019966:Substance-Related Disorders
D000588:Amines; D004338:Drug Combinations; D004983:Ethanolamines; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D010879:Piperazines