Treatment of Bacteroides endocarditis with carbenicillin.
A heroin addict developed acute bacterial endocarditis with Streptococcus viridans and Bacteroides melaninogenicus. Although blood cultures became negative during penicillin G and clindamycin therapy there was little clinical response. Prompt clinical improvement was achieved with intravenous carbenicillin in a dose of 40 g daily. In vitro testing supported the superiority of carbenicillin therapy in this patient.
D000328:Adult; D001442:Bacteroides Infections / Q000175:diagnosis / Q000188:drug therapy*; D002228:Carbenicillin / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010400:Penicillin G / Q000627:therapeutic use; D010403:Penicillin Resistance; D001443:Prevotella melaninogenica; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy
D002981:Clindamycin; D002228:Carbenicillin; D010400:Penicillin G