Inactivation of viruses in serum with binary ethyleneimine.
The inactivation os six strains from three different groups of viruses with 0.001 M binary ethyleneimine at 37 C proceeded at the same rate in either bovine serum or cell culture medium. The inactivant did not impair the growth-promoting capacity of bovine serum used in cell culture, nor did it affect the antibody activity of guinea pig hyperimmune serum.
D000818:Animals; D005537:Aphthovirus / Q000187:drug effects*; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D001769:Blood; D002417:Cattle; D002460:Cell Line; D006168:Guinea Pigs / Q000276:immunology; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera; D013696:Temperature; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D001388:Aziridines; D001389:Azirines; D007106:Immune Sera