An experimental non-invasive animal technique for measuring nasal airway resistance: I. Adrenergic and antihistaminic agents.
A non-invasive technically simple and sensitive method is described for the determination of nasal airway resistance (NAR). Aerosolized saline elicited a +/- 7% change in baseline NAR, duration 2 minutes, whereas aerosolized histamine increased NAR, duration is greater than 30 minutes. Aerosolized phenylephrine, norepinephrine, and oxymetrazoline elicited dose related decongestive response in a naris subjected to prior congestion (aerosolized histamine). Both H1 and H2 receptors are involved in the congestive response to intranasal histamine.
D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D004285:Dogs; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D008722:Methods; D009666:Nose / Q000502:physiology*; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors
D000336:Aerosols; D006634:Histamine H1 Antagonists; D013566:Sympathomimetics; D006632:Histamine