Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides.
The synthesis and pharmacological screening for anti-apomorphine, stomach emptying and local anaesthetic activities of some new piperidylbenzamides is described. One of these, N-(1'-benzyl-4'-piperidyl)-2-methoxy-4-amino-5-chlorobenzamide (clebopride) is more potent than metoclopramide in tests related to blockade of cerebral dopamine receptors.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D051379:Mice; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
D001549:Benzamides; D010880:Piperidines; D008787:Metoclopramide; D001058:Apomorphine; D003913:Dextroamphetamine; D004298:Dopamine