Participation of leukemia cells in immune responses.
Cells of a transplantable lymphoid leukemia of mice were tested in vivo and in vitro to see which features of normal lymphoid cells were retained in spite of malignant transformation and lack of growth control. Leukemia cells phagocytosed, adhered to glass, possessed receptors for immunoglobulin, participated in the immune response against SRBC (probably by amplifying a normal response through attachement of antibodies on their surfaces), became recruited into inflammatory reactions elicited by grafting allogeneic of syngeneic skin, and apparently joined graft-versus-host and host-versus-graft reactions, contributing toward damage of hemopoietic target tissues.
D000818:Animals; D000917:Antibody Formation; D001665:Binding Sites; D002448:Cell Adhesion; D003176:Complement C3 / Q000378:metabolism; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D006789:Host vs Graft Reaction; D007111:Immunity, Cellular; D007141:Immunoglobulin Fc Fragments; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010587:Phagocytosis
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments