[The function of shuttle systems of liver extramitochondrial hydrogen transport in experimental atherosclerosis].
An enzymatic activity of shuttle systems for reduction equivalents transport (malate-aspartate, glycerophosphate, lactate, glutamate and beta-hydroxybutyrate dehydrogenase) was studied spectrophotometrically in liver tissue of intact rabbits and animals with experimental atherosclerosis. Content of malate, oxaloacetate, glutamate, alpha-ketoglutarate, alpha-glycerophosphate, dihydroacetone phosphate, lactate, pyruvate, beta-hydroxybutyrate and acetoacetate were studied. In experimental atherosclerosis coordinated functioning of the enzymes, which participate in the utilization of the cytoplasmic NAD-H2 and the alteration in the ratio of reduced and oxidized metabolites in the systems, were found to be impaired.
D000090:Acetoacetates / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D001692:Biological Transport; D003593:Cytoplasm / Q000378:metabolism; D004099:Dihydroxyacetone Phosphate / Q000378:metabolism; D004195:Disease Models, Animal; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D005994:Glycerophosphates / Q000378:metabolism; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D010071:Oxaloacetates / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism
D000090:Acetoacetates; D005971:Glutamates; D005994:Glycerophosphates; D006885:Hydroxybutyrates; D007656:Ketoglutaric Acids; D007773:Lactates; D008293:Malates; D010071:Oxaloacetates; D011773:Pyruvates; D004099:Dihydroxyacetone Phosphate; D006859:Hydrogen; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D008291:Malate Dehydrogenase; D005969:Glutamate Dehydrogenase
Sostoianie chelnochnykh sistem transporta ekstramitokhondrial'nogo vodoroda v tkani percheni pri eksperimental'nom ateroskleroze