[Hydrogen ion metabolism and parenteral alimentation].
The necessity of using solutions and emulsions in parenteral nutrition of solutions directly utilisable by the cell has led to the manufactur of substances with a composition and physico-chemical nature which greatly alters H+ ions balance. Theoretical calculation and various experimental protocois have shown that the production of H+ ions may be multiplied by 3 or 4. This explains the complications of metabolic acidosis seen in association with prolonged parenteral nutrition. There are two main sources : lipid emulsions and amino-acid solutions. One litre of lipid emulsion may provide 37 to 60 mEq of H+ ions. According to their formula, amino acid solutions may consume, or more often provide, large amounts of H+ ions (up to 20 mEq/gram of nitrogen). These physiopathological concepts should be taken into consideration in defining the compositions of fluids for parenteral nutrition, in particular when renal function is impaired.
D000138:Acidosis / Q000517:prevention & control; D000596:Amino Acids / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004655:Emulsions; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D050356:Lipid Metabolism; D010288:Parenteral Nutrition / Q000009:adverse effects; D010289:Parenteral Nutrition, Total / Q000009:adverse effects
D000596:Amino Acids; D004655:Emulsions; D006859:Hydrogen
Métabolisme des ions H+ et alimentation parentérale.