[Stabilization of biological membranes with various acetylene amines].
In experiments with mitochondrial membranes and membranes of the endoplasmatic reticulum of the rats' liver the membrane-stabilizing action of a number of unsaturated amines was evaluated. The acetylene compounds studied reduced the extent of the membranes damage following UV-irradiation, treatment with detergents and their incubation in a hypoosmotic medium. Such an action displayed gutimine and sovcaine. Hydrated compounds, analogues of acetylene amines are devoid of the ability to raise the resistance of the cellular organoids membranes to damaging factors
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D003902:Detergents / Q000494:pharmacology; D003992:Dibucaine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects*; D007038:Hypotonic Solutions; D050356:Lipid Metabolism; D008930:Mitochondria, Liver / Q000187:drug effects*; D009249:NADP / Q000494:pharmacology; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology; D014466:Ultraviolet Rays
D003902:Detergents; D007038:Hypotonic Solutions; D009249:NADP; D011189:Potassium Chloride; D013890:Thiourea; D003992:Dibucaine; D001205:Ascorbic Acid
Stabilizatsiia biologicheskikh membran nekotorymi atsetilenovymi aminami.