Inhibitory effect of fentonium on gastric acid secretion in different laboratory animals.
The influence of fentonium, a new derivative of hyoscyamine, on the gastric secretion has been evaluated in rats, cats and dogs. The compound appeared to be able to markedly reduce the gastric hypersecretion produced by pentagastrin, caerulein and bethanechol; its antagonizing activity against histamine stimulation was poor.
D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology*; D002415:Cats; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology; D006634:Histamine H1 Antagonists; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D013045:Species Specificity
D001286:Atropine Derivatives; D006634:Histamine H1 Antagonists; D011976:Receptors, Muscarinic