[Interaction of complex esters of hydroxyethylsulfones with DNA in vitro].
The effect of a number of alkyl disulphones on the parameters of DNA melting following its treatment with the substances involved was studied under in vitro conditions: it was found that bis(acetyl oxyethylsulphonyl) methane and bis (formyl oxyethylsulphonyl) methane reduced the temperature of DNA melting. As a result of decomposition of oxyethylsulphone esters the corresponding vinylsulphones were formed. It is suggested that the parameters of DNA melting change under the influence of vinylsulphones being formed. There is some correlation between antitumor activity of alkyl disulphones and their capacity to interact with DNA. Inactive or insignificantly active substances would not influence the parameters of DNA melting, while the two substances under consideration possessed a high antitumor effect on ascites forms of animal tumors.
D000476:Alkanesulfonates; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA; D004952:Esters; D006863:Hydrogen-Ion Concentration; D007513:Isethionic Acid / Q000627:therapeutic use; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D000476:Alkanesulfonates; D004952:Esters; D004247:DNA; D007513:Isethionic Acid
Vzaimodeĭstvie slozhnykh éfirov oksiétilsul'fonov s DNK in vitro