Stability of frozen solutions of cefazolin sodium.
The stability of frozen solutions of cefazolin sodium was investigated in nine commonly used diluents at concentrations of 1 g with 2.5 ml, 500 mg with 100 ml and 10 g with 45 ml in both glass and polyvinylchloride plastic containers. The diluents were: Water for Injection USP; 0.9% Sodium Chloride Injection USP; 5% Dextrose Injection USP (D5W); D5W with 0.02% sodium bicarbonate; D5W in Lactated Ringer's Injection USP; Lactated Ringer's Injection USP; Ionosol B in D5W; Normasol M in D5W; and Plasmalyte in D5W. Frozen cefazolin sodium solutions, containing Water for Injection USP, 5% Dextrose Inection USP or 0.9% Sodium Chloride Injection USP as the diluents, retained more than 90% of labeled potency for up to 26 weeks when frozen within one hour after reconstitution and held at -10 C or -20 C. Frozen cefazolin sodium solutions, made with other diluents, were stable for up to four weeks when frozen within one hour after reconstitution and held at -10 C.
D000818:Animals; D001681:Biological Assay; D002437:Cefazolin / Q000032:analysis* / Q000494:pharmacology / Q000633:toxicity; D002511:Cephalosporins / Q000032:analysis*; D004355:Drug Stability; D005260:Female; D005615:Freezing; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D051379:Mice; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
D002511:Cephalosporins; D002437:Cefazolin