Comparative stability of cephalothin and cefazolin in buffer or human serum.
A marked loss in potency was observed when cephalothin was incubated for 5 h in human serum at 37 degrees C. Cefazolin was stable under these conditions.
D002021:Buffers; D002437:Cefazolin / Q000032:analysis / Q000097:blood; D002511:Cephalosporins / Q000032:analysis; D002512:Cephalothin / Q000032:analysis / Q000097:blood; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques
D002021:Buffers; D002511:Cephalosporins; D002437:Cefazolin; D002512:Cephalothin