[An experimental study on the pathogenesis of the acute pulmonary insufficiency (author's transl)].
Parameters of the lungs as Compliance PaCO2, PaO2, have been measured in connection with experimental, pathophysiological insults like hematoma, bone marrow intravasation and hemorrhage, in rabbits. Concerning the compliance quotient, a statistically proved decrease was found within the groups, which have had a hematoma. Moreover, the histological picture of the lungs from rabbits with a hematom showed perivascular and intersitial edema and considerable atelectases. Serum of animals, which have had a hematom for at least 24 h has been fractionated by gel chromatography; low molecular weight substances of the fractionated serum were injected into healthy recipients. Thereafter, measurement of the centralvenous pressure suggests the appearance of substances, pharmacodynamic similar to 5-Hydroxytryptamin, in blood of rabbits with hematom.
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000378:metabolism; D005260:Female; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000473:pathology; D008170:Lung Compliance; D010101:Oxygen Consumption; D011817:Rabbits; D012131:Respiratory Insufficiency / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
D002245:Carbon Dioxide
Experimentelle Untersuchungen zur Pathogenese der akuten pulmonalen Insuffizienz.