Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines.
Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, indicating that human gastric mucosa contains at least two separate hormone-sensitive adenylate cyclases.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000318:Adrenergic beta-Agonists; D002927:Cimetidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis; D004837:Epinephrine / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000201:enzymology*; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D010437:Peptic Ulcer / Q000201:enzymology; D011433:Propranolol / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D006632:Histamine; D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D004837:Epinephrine