Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction.
Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.
D000818:Animals; D000941:Antigens; D001789:Blood Group Antigens; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006087:Graft vs Host Reaction; D006734:Horse Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006736:Horses; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D007167:Immunotherapy / Q000662:veterinary*; D007668:Kidney / Q000473:pathology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D012867:Skin / Q000473:pathology; D013950:Thymus Gland / Q000637:transplantation*; D014184:Transplantation, Homologous
D000941:Antigens; D001789:Blood Group Antigens