Secretion of various antimicrobial substances in dogs with experimental bacterial prostatitis.
Bacterial prostatitis in dogs was induced by injection of an E. coli 06 suspension into a branch of the prostatic artery. Three to six days later, secretion from the inflamed glands was obtained by pilocarpine stimulation and the concentrations of trimethoprim, sulphamethoxazole, erythromycin, doxycycline and ampicillin were measured during constant infusion of these drugs. In the prostatic secretion, only the concentrations of the lipid soluble substances trimethoprim and erythromycin exceeded the corresponding plasma levels. These two substances may therefore be of value in the treatment of bacterial prostatitis.
D000667:Ampicillin / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004285:Dogs; D004318:Doxycycline / Q000378:metabolism / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004917:Erythromycin / Q000378:metabolism / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000188:drug therapy*; D006863:Hydrogen-Ion Concentration; D008297:Male; D011467:Prostate / Q000378:metabolism; D011472:Prostatitis / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000378:metabolism / Q000627:therapeutic use; D014295:Trimethoprim / Q000378:metabolism / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004917:Erythromycin; D000667:Ampicillin; D014295:Trimethoprim; D013420:Sulfamethoxazole; D004318:Doxycycline