Leucocyte migration test and hypersensitivity to glafenin.
The leucocyte migration test (LMT) was performed on 20 patients with an intolerance to glafenin--a non-narcotic analgesic drug. LMT was found to be positive in 50% of the subjects with intolerance, a highly significant percentage as compared with the control groups. HSA-glafenin was found to be the most appropriate method for presenting the antigen, but glafenin and its hydroxylated metabolites were only found to induce a migration inhibition in the subjects intolerant to glafenin.
D000328:Adult; D000368:Aged; D002464:Cell Migration Inhibition; D002465:Cell Movement; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005897:Glafenine / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000276:immunology; D062367:ortho-Aminobenzoates / Q000009:adverse effects*
D012709:Serum Albumin; D062367:ortho-Aminobenzoates; D005897:Glafenine