Synthesis of some new phenothiazine derivatives of expected medicinal value.
2-Chloroacetyl phenothiazines were reacted with certain phenols and salts of some acids under different conditions to yield 2-substituted acetylphenothiazines. Another series of 10-substituted phenothiazines was synthesized by treatment of 10-chloroacetylphenothiazine with either the appropriate amines or salts of the respective acids. The optimum experimental conditions for the preparation of 2-chloroacetyl-10-acetyl-phenothiazine by Friedel-Crafts reaction were studied. Also N-chloroacetyl-o-aminophenol was synthesized in high yield by a simple method. The preliminary pharmacological screening showed that two of these compounds possess a low order of tranquillizing activity.
D000818:Animals; D000830:Animals, Laboratory; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007279:Injections, Subcutaneous; D010640:Phenothiazines
D014150:Antipsychotic Agents; D010640:Phenothiazines