Effect of streptovirudin on parainfluenza 3 virus multiplication.
Streptovirudin (SV) in a concentration of 100 microng/ml reduced the multiplication of parainfluenza 3 virus by about 3.5 log units. When uninfected WISH cells were treated for 2 and 12 hours with 100 mug/ml of SV, 3H-thymidineincorporation was decreased, but no marked differences were observed in the incorporation of 3H-uridine. The level of intracellular cyclic adenosine monophosphate (c-AMP) was found to decrease in SV-treated cells.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D005998:Glycine / Q000378:metabolism; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects* / Q000254:growth & development; D018108:Respirovirus / Q000187:drug effects*; D013302:Streptomyces; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D005998:Glycine; D013936:Thymidine; D014529:Uridine