Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators.
Oxatomide is a new potent inhibitor of anaphylactic and allergic reactions. After oral administration, the compound both inhibits the release of endogenous histamine and prevents the effects of exogensous histamine, at comparable doses. The combination of these effects appears to be the basis of the effectiveness of oxatomide in allergic reactions and may lead to clinical application different from classical antihistaminics and from cromoglycate.
D000284:Administration, Oral; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D004285:Dogs; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000517:prevention & control; D007082:Ileum / Q000187:drug effects; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide