Absence of specific mixed leukocyte culture reactivity during graft-versus-host disease and following bone marrow transplant rejection.
Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-versus-host disease was caused by antigens that stimulate in the mixed lymphocyte culture assay.
D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D013997:Time Factors; D014184:Transplantation, Homologous