[Structure-activity relationships of halogenated phenylethanolamine and phenoxypropanolamine].
12 compounds from the series of halogenated phenylethanolamines and phenoxypropanolamines were tested at the isolated rabbit jejunum, and the pD2-and pA2-values were determined. All the substances act beta-adrenolytically. Except for 3,4-dichloronoradrenaline, which stimulates the alpha-receptors, all the compounds still have pronounced beta-mimetic effects. The 2,5-dihalogenated phenylethanolamines and phenoxypropanolamines block the beta-receptors at lower concentrations than 2,4-dihalogen derivatives. The weakest beta-adrenolytic effects at the intestine were found with compounds halogenated at the 3,4-position.
D000319:Adrenergic beta-Antagonists; D000818:Animals; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D007583:Jejunum / Q000187:drug effects*; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship
D000319:Adrenergic beta-Antagonists; D010627:Phenethylamines; D011412:Propanolamines; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine
Struktur-Wirkungs-Beziehungen halogenierter Phenyläthanolamine und Phenoxypropanolamine