[Peculiarities of acid-base reserves in aging].
The age-dependent peculiarities of the acid-base balance at rest and with standard loads were studied in 466 rats. It was found that with age the pH value of blood decreases, the tension of the carbonic acid increases, but the values of BB, BE, SB, and AB do not undergo any significant changes. With loads, old animals showed more profound changes in the system and these changes were of decompensated character. The maximal changes in young animals were registered 1.5 hours after loading, in old rats--3 hours after. The normalization of the shifts in old rats occurred much more slowly than in young animals, and it does not reached the initial value by 24 hours after loading. The analysis of the data obtained shows that with aging the reserve potentialities of the organism's mechanisms of the acid-base balance regulation greatly decrease, which under certain conditions results in disturbance of the given system compensation, thus exerting a negative effect on the body vital processes.
D000136:Acid-Base Equilibrium; D000375:Aging; D000818:Animals; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D006863:Hydrogen-Ion Concentration; D051381:Rats
D002245:Carbon Dioxide
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