Studies on the inhibition of thermolysin.
Thei nhibition of the thermolysin catalyzed hydrolysis of FA-Gly-Leu-NH2 and FA-Gly-Phe-NH2 has been reported. The results suggest a model for substrate and inhibitor binding involving the hydrophobic specificity pocket, Arg-203 and Glu-143.
D001665:Binding Sites; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007930:Leucine / Q000494:pharmacology*; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology*; D010649:Phenylalanine / Q000494:pharmacology*; D013820:Thermolysin / Q000037:antagonists & inhibitors* / Q000378:metabolism
D009842:Oligopeptides; D010649:Phenylalanine; D013820:Thermolysin; D007930:Leucine