[In vitro effect of leukocytic and thymic histones and their fractions on the activity of the causative agent of meningopneumonia].
It was found in studying the antimeningococcus activity of the leukocytic and thymus histones and their fractions that both histones were capable of neutralizing in vitro the activity of the causative agent of meningopneumonia (MP). The neutralization effect was chiefly associated with the F3 fraction rich in arginine and depended on the duration of the histone fraction contact with the MP causative agent, the weight concentration of the histone and the pH of the incubation medium.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002417:Cattle; D002690:Chlamydia Infections / Q000382:microbiology*; D002691:Chlamydophila psittaci / Q000187:drug effects* / Q000472:pathogenicity; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006657:Histones / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007962:Leukocytes; D051379:Mice; D011014:Pneumonia / Q000382:microbiology*; D013950:Thymus Gland; D013997:Time Factors
D003470:Culture Media; D006657:Histones; D001120:Arginine
O vliianii in vitro leĭkotsitarnogo i timusnogo gistonov i ikh fraktsiĭ na aktivnost' vozbuditelia meningopnevmonii