Butadiene diepoxide activation of guanylate cyclase.
A variety of nitroso chemical carcinogens increase the activity of guanylate cyclase (EC 4.6.1.2), the enzyme catalyzing the production of guanosine 3',5'-monophosphate. In the present report, the first non-nitroso chemical carcinogen, butadiene diepoxide, was shown to activate guanylate in a variety of tissues over the concentration range 1-100 mmol/l. At 20 mmol/l concentration, increases were 2- to 17-fold above control. These observations have potential importance since guanosine 3',5'-monophosphate may be involved in cell growth and malignant transformation.
D000818:Animals; D002073:Butanes / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000378:metabolism*; D008297:Male; D051381:Rats; D014018:Tissue Distribution
D002073:Butanes; D002273:Carcinogens; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; C007366:diepoxybutane; D006162:Guanylate Cyclase