Effect of formulation of intramuscular injections of phenothiazines on duration of activity.
Trifluoperazine and pericyazine were formulated using both the hydrochloride and embonate salts, and some comparisons were made with the activity of fluphenazine salt and ester formulations. Simple solutions in polyethylene glycol, gelled aqueous solutions, nonaqueous suspensions, multiple emulsions, and microencapsulated preparations were formulated, and their duration of activity was tested in dogs. While the multiple emulsion system showed some promise, a nylon microcapsule system produced significant prolonged activity of the drug after deep intramuscular injection.
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001058:Apomorphine / Q000037:antagonists & inhibitors; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004285:Dogs; D004655:Emulsions; D005260:Female; D005476:Fluphenazine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D005782:Gels; D007273:Injections, Intramuscular; D008297:Male; D010640:Phenothiazines / Q000008:administration & dosage / Q000494:pharmacology; D011092:Polyethylene Glycols; D012995:Solubility; D012996:Solutions; D013535:Suspensions; D013997:Time Factors; D014268:Trifluoperazine / Q000031:analogs & derivatives / Q000494:pharmacology
D014150:Antipsychotic Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D004655:Emulsions; D005782:Gels; D010640:Phenothiazines; D012996:Solutions; D013535:Suspensions; D014268:Trifluoperazine; D011092:Polyethylene Glycols; D001058:Apomorphine; D005476:Fluphenazine