Metabolism and tissue distribution of mono-2-ethylhexyl phthalate in the rat.
The absorption, distribution and metabolic excretion of mono-2-ethylhexyl [7-14C]phthalate (MEHP) were studied in the rat. This compound was readily absorbed from the gastrointestinal tract. Radioactivity following intravenous administration of 14C-MEHP was rapidly distributed in all tissues, with the highest levels occurring in the liver, kidney, and urinary bladder. Excretion of radioactivity was rapid and approximately 80% of the dose was eliminated 24 hr after oral administration, 72% in the urine and 8% in feces. MEHP was extensively metabolized after oral administration, and the major urinary metabolites were identified as an alcohol, a ketone, and an acid resulting from the side-chain oxidation of MEHP. A trace of o-phthalic acid was also identified.
D000818:Animals; D001711:Biotransformation; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D008297:Male; D010795:Phthalic Acids / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D010795:Phthalic Acids