[A serogenetic approach to the study of Alzheimer's disease (author's transl)].
The analysis of 15 hereditary controlled blood characteristics in 57 Alzheimer-patients revealed abnormalities in the distribution of ABO-blood-groups and phenotypes in the third component of complement system. These data indicate that the phenogenesis of the Alzheimer syndrome is multiconditional and is obviously influenced by selective processes of immuno-genetic factors. This selective vulnerability offers a lead into the elucidation of amyloid deposition in Alzheimer's disease.
D000017:ABO Blood-Group System; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics; D000686:Amyloidosis / Q000276:immunology; D002986:Clinical Trials as Topic; D003176:Complement C3; D003165:Complement System Proteins; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D000017:ABO Blood-Group System; D003176:Complement C3; D003165:Complement System Proteins
Ein serogenetischer Beitrag zur Atiopathologenese der Alzheimerschen Erkrankung