Partial tolerant state against H-2 disparate cells. No impaired specific reactivity in MLC, GVH, or antibody production.
Injection of CBA mice with H-2-compatible lymphoid cells from C3H hybrids induces a specific reduction of the mixed lymphocyte culture (MLC) response of their lymphoytes. This is not the case after injection of H-2-disparate C3H-hybrid cells, presumably because they are rapidly eliminated due to the immune response of the host. This investigation shows that CBA mice injected with CBA X C57Bl cells (H-2-disparate) at an age of 0-3 days, but not older, develop a specifically reduced MLC response after infusion of C3H X C57Bl cells as adults, indicating that they were tolerant to the C57Bl-determined antigens. However, lymphocytes from such mice showed a normal reactivity against C57Bl as assessed by MLC, graft-versus-host tests, and capacity to produce specific antibodies.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D002455:Cell Division / Q000187:drug effects; D006087:Graft vs Host Reaction; D006648:Histocompatibility; D007108:Immune Tolerance; D007518:Isoantibodies / Q000032:analysis; D007959:Lymphocyte Culture Test, Mixed; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008937:Mitomycins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D014184:Transplantation, Homologous
D007518:Isoantibodies; D008937:Mitomycins