Absorption of the beta-adrenergic-blocking agent, nadolol, by mice, rats, hamsters, rabbits, dogs, monkeys, and man: an unusual species difference.
1. Dogs absorbed [14C]nadolol almost completely (88--104%) after oral administration of 10--75 mg/kg. In contrast, mice, rats, hamsters, and rabbits, given oral doses of 20 mg/kg, absorbed, at most, 25%. After administration of oral doses of 2--75 mg/kg, monkeys absorbed no more than an average of 30%. Six monkeys given oral doses of 10 mg/kg absorbed 12--44%. 2. In rats, [14C]nadolol was orally absorbed to an average of 13.7--17.5%, whether given in suspension or in solution, indicating that absorption was not limited by rate of dissolution nor by solubility. 3. Mildly hypertensive humans given single doses of [14C]nadolol (2 or 80 mg, orally) and normal subjects given single doses (10 mg, orally) absorbed an average of 20.4--33.3%.
D000319:Adrenergic beta-Antagonists / Q000378:metabolism*; D000818:Animals; D006224:Cricetinae; D004285:Dogs; D005260:Female; D000882:Haplorhini; D006801:Humans; D007408:Intestinal Absorption; D008253:Macaca mulatta; D008297:Male; D008647:Mesocricetus; D051379:Mice; D011412:Propanolamines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines