[Respiratory stimulant effect of S 2620 in the dog anesthetized with pentobarbital].
In the dog under pentobarbitone anesthesia, the intravenous injection of 1 mg/kg S 2620 is followed by a significant increase in respiratory rate, PaO2 and pHa and by a large decrease in PaCO2. Cervical vagotomy and chemoreceptor denervation reduced and even abolished these effects. They can be induced again by a second intravenous injection or by direct instillation in the fourth ventricle. These results suggest a central action of the drug.
D000768:Anesthesia, General; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D010100:Oxygen / Q000097:blood; D010424:Pentobarbital / Q000008:administration & dosage; D010879:Piperazines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects; D014227:Triazines / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D000697:Central Nervous System Stimulants; D010879:Piperazines; D014227:Triazines; D002245:Carbon Dioxide; D010424:Pentobarbital; D010100:Oxygen
Action stimulante respiratoire du S 2620 chez le chien anesthésié au pentobarbital