Effects of a new selective beta1-adrenoceptor agonist on amylase secretion from the rat parotid gland.
The effects of a new selective beta1-adrenoceptor agonist, (--)-1-(4-hydroxyphenoxy)-3-isopropyl-amino-propanol-2-hydrochloride (H 133/22), on amylase secretion from the rat parotid gland were investigated in an in vitro system. The results were compared to the secretory responses obtained with noradrenaline, adrenaline, methoxyamine and terbutaline. H 133/22 was found to be a potent enzyme secretagogue and appeared even more effective than noradrenaline and adrenaline, particularly at low concentrations. The beta1-adrenoceptor agonist, terbutaline, also stimulated amylase discharge from the parotid gland but was much less potent than H 133/22. Methoxyamine had no effect on enzyme secretion. We suggest that the adrenergic stimulation of amylase secretion from the rat parotid gland is mainly mediated by beta1-receptors.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D010306:Parotid Gland / Q000187:drug effects / Q000201:enzymology*; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D000681:Amylases