[Successful therapy of a severe dextran incident using histamin H1- and H2-receptor blockaders].
A case of a severe systemic anaphylactoid reaction is reported in a patient treated with dextran 60 to prevent venous thrombosis. Significant improvement of clinical symptoms occurred after the usual treatment of such incidents with corticosteroids, histamine H1 receptor antagonists, and plasma substitutes was supplemented with a histamine H2 receptor antagonist. We would therefore like to recommend that for such cases a histamine H2 receptor antagonist should be given in addition to the usual medication with corticosteroids and histamine H1 receptor antagonists. However, the value of complete histamine antagonism in these rather rare occurrences, can only be determined after furtherexperience has been gained.
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy*; D003911:Dextrans / Q000009:adverse effects*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011183:Postoperative Complications
D003911:Dextrans; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists
Erfolgreiche Therapie eines schweren Dextran-Zwischenfalles mit Histamin H1- und H2-Receptorenblockern. Ein fallbericht.