[Sulfaphenazole binding by p-450 cytochrome of liver microsomes of rats and its effect of cytochrome-p-450-reductase].
Tests set up "in vitro" on the rats' liver microsomes showed that sulfaphenazol, which in an inhibitor of the mixed type N-and O-demethylation, is bound as a substrate of the II type (aniline type). It attenuates spectral changes caused by aniline and vice versa. Sulfaphenazol inhibits the activity of the ADPH cytochrome-P-450-reductase.
D000818:Animals; D001667:Binding, Competitive; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003579:Cytochrome Reductases / Q000037:antagonists & inhibitors*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009249:NADP; D009251:NADPH-Ferrihemoprotein Reductase / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D051381:Rats; D013426:Sulfaphenazole / Q000494:pharmacology*
D013426:Sulfaphenazole; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D003579:Cytochrome Reductases; D009251:NADPH-Ferrihemoprotein Reductase
Sviazyvanie sul'fafenazola tsitokhromom P-450 mikrosom pecheni krys i ego vliianie na tsitokhrom-P-450-reduktazu