Effects of histamine on the human penis muscle in vitro.
Histamine produced three types of effects on corpus cavernosa muscle of the human penis: contraction, relaxation or a contraction followed by a relaxation. 2-Methylhistamine, which acts mainly on histamine H1-receptors, stimulated all the penile strips tested. 4-Methylhistamine, which acts predominantly on H2-receptors produced relaxation in two-thirds of the strips and contraction in the rest. Contractions produced by histamine, 2-methyl histamine and 4-methylhistamine were selectively abolished by mepyramine. Burimamide antagonised the relaxant effect of histamine and of 4-methylhistamine. Corpus cavernosa muscle of the human penis has both histamine H1- and H2-receptors.
D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010413:Penis / Q000187:drug effects*; D010646:Phentolamine / Q000494:pharmacology
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D008761:Methylhistamines; D006632:Histamine; D007545:Isoproterenol; D010646:Phentolamine