[Long-term experiments on toleration of the ganglionic blockader hygronium].
In tests set up on albino rats, guinea pigs and rabbits the chronic toxicity of hygronium--a new original ganglion blocking agent of a short-term action was studied. With its daily intraperitoneal administration for 14 days in doses of 10 and 40 mg/kg (1/10 and 1/3 DL50) the drug produces in some of the animals, chiefly in rabbits and guinea pigs receiving 40 mg/kg, readily reversible histological changes in some of their internal organs. Hygronium does not cause any local irritating effect
D000818:Animals; D005730:Ganglionic Blockers / Q000633:toxicity*; D006168:Guinea Pigs; D011759:Pyrrolidines / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D005730:Ganglionic Blockers; D011759:Pyrrolidines
O perenosimosti gangliolitika gigroniia v khronicheskom éksperimente.