Alteration of amicrofilaremia in Dipetalonema viteae infected hamsters with immunosuppressive drugs.
Dipetalonema viteae-infected hamsters with amicrofilaremic infections were subjected to immunosuppressive therapy. Methyl prednisolone acetate caused the most severe recrudescence of microfilariae while cyclophosphamide caused a low level, transient microfilaremia. Saline injected control hamsters remained amicrofilaremic. Neither drug influenced the number of adult worms recovered at necropsy in the treated hamsters compared with control hamsters.
D000818:Animals; D001769:Blood / Q000469:parasitology; D006224:Cricetinae; D003520:Cyclophosphamide / Q000627:therapeutic use; D004153:Dipetalonema / Q000302:isolation & purification*; D004154:Dipetalonema Infections / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone