[Phencarol--an antihistaminic preparation from the quinuclidylcarbinol group].
A high antihistaminic activity of quinuclidyl-3-diphenylcarbinol (phencarol) has been ascertained. In pharmacological experiments phencarol is superior to dimedrol (diphenhydramine), both as concerns its antihistaminic activity and the duration of its action. Unlike dimedrol and diprazine (promethazine) it has no inhibitory effect on the central nervous system. With its clinical use phencarol is effective in treating urticaria, Quincke's edema and allergic skin reactions. The drug is well tolerated by the patients and does not produce any inhibitory or soporific action. Phencarol has an authorized permission to be used for medical purposes.
D000284:Administration, Oral; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D001921:Brain / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D004155:Diphenhydramine / Q000494:pharmacology; D004347:Drug Interactions; D004569:Electroencephalography; D006168:Guinea Pigs; D006632:Histamine / Q000506:poisoning; D006634:Histamine H1 Antagonists; D006967:Hypersensitivity / Q000188:drug therapy; D007082:Ileum / Q000187:drug effects; D007275:Injections, Intravenous; D051379:Mice; D011398:Promethazine / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D051381:Rats
D001463:Barbiturates; D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D011812:Quinuclidines; D006632:Histamine; D004155:Diphenhydramine; D011398:Promethazine; C014742:quifenadine
Fenkarol--protivogistaminnyĭ preparat iz gruppy khinuklidilkarbinolov