[Effect of several psychopharmacologic preparations on adaptation to stressful conditions].
Experiments staged on rats demonstrated that the formation of pathological states caused by stress and accompained by the development of ulcerative lesion of the gastric mucosa are associated with the degree of the catecholamines level drop in the mesencephalon and hypothalamus. The application of seduxen and also of combinations consisting of L-DOPA with seduxen, or with an L-adrenoblocking agent-pyroxan tends to reduce the frequency of developing ulcerative lesions of the stomach. The protective effect produced by the combination of L-DOPA with an L-adrenoblocking agent--pyroxan is barred by an additional administration of an beta-adrenoblocking agent--inderal.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000818:Animals; D001931:Brain Mapping; D003975:Diazepam / Q000627:therapeutic use; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010646:Phentolamine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011602:Psychophysiologic Disorders / Q000188:drug therapy* / Q000378:metabolism; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism; D013315:Stress, Psychological / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D011619:Psychotropic Drugs; D007980:Levodopa; D004295:Dihydroxyphenylalanine; D011433:Propranolol; D003975:Diazepam; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine
Vliianie nekotorykh psikhofarmakolegicheskikh preparatov na adaptatsiiu v usloviiakh stressa