Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats.
Cis (alpha)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (beta)-flupenthixol and (-)-butaclamol are not. alpha-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the beta-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D005475:Flupenthixol / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011807:Quinolizines / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013237:Stereoisomerism; D013892:Thioxanthenes / Q000494:pharmacology*
D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D011807:Quinolizines; D011954:Receptors, Dopamine; D013892:Thioxanthenes; D011388:Prolactin; D005475:Flupenthixol; D006220:Haloperidol; D002746:Chlorpromazine