[Metabolic acidosis and intravenous injections of fat emulsions (role of phospholipids. Experimental study)].
In explanation of metabolic acidosis during parenteral nutrition, the authors considered the supply of H+ ions by fat emulsion, containing phospholipids of egg or soy. During intravenous infusions of 24 grams of lecithins to two healthy subjects, they observed an increased output H+ ions in urine, about 74,05 and 75,88 mEq, and a metabolic acidosis of the plasma. The theorically forcasted supply of production was 74,6 mEq. Indeed the metabolism of phospholipids supplies phosphoric ions (PO4H3), giving H+ ions at pH 7,40. The most used fat emulsions are able to give between 37 (intralipid 10%) and 61 (lipihysan 15%) mEq of H+ ions/liter.
D000138:Acidosis / Q000209:etiology*; D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010743:Phospholipids / Q000008:administration & dosage / Q000009:adverse effects*
D004041:Dietary Fats; D010743:Phospholipids
Acidose métabolique et injection intra-veineuse d'émulsions lipidiques (role des phospholipides. Etude expérimentale)