Treatment of comatose patients by mechanical hyperventilation.
In case of cranial trauma, early respiratory troubles either of central or peripheral origin often accelerate the deterioration of the neurological situation. The different values of PCO2, PO2, pH and alcaline reserve measured on samples of CSF in comatose patients prove the central acidosis related to metabolic and vascular disorders in the damaged areas. Our results confirm the correlation between the importance of this disturbances and the severity of the trauma. It is thus necessary to insure patients of satisfactory respiration conditions. The tracheobronchial cleansing is applicable to intubated or tracheotomized patients by an instillation of 5ml of simple or bicarbonated physiological serum 4 to 6 times a day, followed by repeated aspirations and associated to a preventive endotracheal instillation of 80 mg of Gentamycin 4 times a day. Moreover we use controlled respiration which does not modify the gazometric parameters in the CSF but which assures patients a normoxia and moderate hypocapnia with a decrease of intracranial hypertension. Treatment by controlled hyperventilation must be precocious, because the recuperation at the level of the damaged zones is very slow.
D000328:Adult; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood / Q000134:cerebrospinal fluid; D003128:Coma / Q000097:blood / Q000134:cerebrospinal fluid / Q000628:therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood / Q000134:cerebrospinal fluid; D012121:Respiration, Artificial; D013223:Statistics as Topic
D001639:Bicarbonates; D002245:Carbon Dioxide; D010100:Oxygen