Ketamine sequelae. Evaluation of the ability of various premedicants to attenuate its psychic actions.
The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied. These included three benzodiazepines, droperidol and 'neurolept' combinations and four commonly-used premedicants. When given intravenously 10 min before induction of anaesthesia flunitrazepam and lorazepam gave best results. In a subsequent study, these two benzodiazepines and diazepam were given intravenously 30-40 min before induction of anaesthesia. There was no doubt that 4 mg lorazepam gave the greatest protection and is worthy of further study in this respect.
D000701:Analgesics, Opioid / Q000627:therapeutic use; D000771:Anesthesia, Intravenous / Q000523:psychology*; D003693:Delirium / Q000517:prevention & control; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007649:Ketamine / Q000009:adverse effects*; D011229:Preanesthetic Medication; D013997:Time Factors; D014149:Tranquilizing Agents / Q000627:therapeutic use
D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D014149:Tranquilizing Agents; D007649:Ketamine