[The metabolism of delta4-3-oxosteroids in rat liver].
The enzymatic reactions are described by which delta4-3-oxosteroids, specially testosterone, are inactivated in rat liver. The delta4-3-oxosteroid-5 alpha-reductase in liver microsomes was studied intensively and it was found that it is an enzyme system. The 5 alpha-reduction of testosterone with NADPH or with NADH depends upon different enzymes or enzyme systems.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism; D000818:Animals; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D051381:Rats; D012737:Sex Factors; D013739:Testosterone / Q000378:metabolism*
D009243:NAD; D013739:Testosterone; D009249:NADP; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Der Stoffwechsel von delta4-3-Oxosteroiden in der Rattenleber