Effect of methylated PGE2 analogs given orally on pancreatic response to secretin in man.
The effect of two methylated PGE2 analogs given orally on the pancreatic response to intravenous secretin has been studied in 8 healthy subjects. The secretion of bicarbonate was not changed by these PGE2 analogs. The secretion of enzymes during infusion of PGE2 analogs was significantly greater than in the control.
D000328:Adult; D000681:Amylases / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D002918:Chymotrypsin / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology*; D013997:Time Factors
D001639:Bicarbonates; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D011506:Proteins; D012633:Secretin; D000681:Amylases; D002918:Chymotrypsin