Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances.
A number of 3-(1H-tetrazol-5-yl)chromones were synthesized and found to have antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test. These compounds are active when administered orally in rats and of possible value for the treatment of asthma.
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D012882:Skin Tests; D013777:Tetrazoles / Q000138:chemical synthesis / Q000494:pharmacology
D002867:Chromones; D006634:Histamine H1 Antagonists; D013777:Tetrazoles