[Effect of 1,4-benzodiazepine derivatives on the toxic action of oxygen under increased pressure].
The 1,4-benzodiazepine derivatives (diazepam, nitrazepm, lorazepam, clonazepam and two newly synthetized compounds of this series) increase the resistance of albino rats and rabbits to the toxic effect of oxygen under high pressure (7 and 5.5 atm respectively). The compounds under study are apt to avert over a long period the development of metabolic acidosis which appears following the action of high-pressure oxygen on the body.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000142:Acidosis, Respiratory / Q000517:prevention & control; D000531:Altitude; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001273:Atmosphere Exposure Chambers; D001769:Blood / Q000187:drug effects; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D000860:Hypoxia / Q000188:drug therapy; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D051379:Mice; D009567:Nitrazepam / Q000494:pharmacology; D010100:Oxygen / Q000633:toxicity*; D010919:Placebos; D011312:Pressure; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D014151:Anti-Anxiety Agents; D010919:Placebos; D002998:Clonazepam; D009567:Nitrazepam; D008140:Lorazepam; D003975:Diazepam; D010100:Oxygen
Vliianie proizvodnykh 1,4-benzodiazepina na toksicheskoe deĭstvie kisloroda pod povyshennym davleniem