Increased hemoglobin-oxygen affinity in patients with pancreatitis associated with type I and V hyperlipoproteinemia.
Oxyhemoglobin dissociation curves were performed from blood of subjects with pancreatitis associated with Type V and Type I hyperlipoproteinemia. The hemoglobin-oxygen affininty was markedly increased with P50 varying from 22.3 to 17.7 mmHg. As the hyperlipoproteinemia subsided the clinical and laboratory signs of pancreatic affection disappeared. The increased hemoglobin-oxygen affinity and decreased flow of red cells due to hyperchylomicronemia in the microcirculation may lead to tissue hypoxia, which may act as a precipitating injurious factor leading to pancreatitis during severe hyperlipemia.
D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism*; D010195:Pancreatitis / Q000097:blood* / Q000209:etiology; D014280:Triglycerides / Q000097:blood
D002914:Chylomicrons; D004163:Diphosphoglyceric Acids; D008055:Lipids; D010108:Oxyhemoglobins; D014280:Triglycerides; D002784:Cholesterol; D010100:Oxygen