Comparison of a new antihistamine HC 20-511 with cyproheptadine (Periactin) in chronic urticaria.
The effect and tolerance of a new antihistamine, HC 20-511, in daily doses of 2 and 4 mg was compared with cyproheptadine (Periactin) 8 mg daily in 50 cases of chronic urticaria. HC 20-511 4 mg daily proved to be the most effective, rapid and long-lasting. HC 20-511 had less sedative effect than cyproheptadine, but both possessed the same appetite-stimulating effect. However, this was not noted with the smaller dosage of HC 20-511.
D000328:Adult; D002986:Clinical Trials as Topic; D003533:Cyproheptadine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D014581:Urticaria / Q000188:drug therapy*
D006634:Histamine H1 Antagonists; D003533:Cyproheptadine