[Study of the biosynthesis of a carbohydrate fragment of rubomycin].
When the rubomycin-producing organism was grown in the presence of an evenly labeled C14-glucose and various non-labeled carbon sources, the carbohydrate part of the antibiotic also became evently labeled. The activity of I carbon atom of rubomycin sugar grown against the background of non-labeled glycerol was almost 3 times higher than the respective value of the aglycone activity. C14-acetate, C14-propionate, C14-methionine and daunosamine were not incorporated. The data are indicative of the fact that there was no splitting of the glucose carbon skeleton during conversion of glucose into amino sugar.
D000588:Amines / Q000378:metabolism; D002250:Carbon Radioisotopes; D003470:Culture Media; D003630:Daunorubicin / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism; D006595:Hexosamines / Q000096:biosynthesis*; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D013302:Streptomyces / Q000378:metabolism; D013997:Time Factors
D000588:Amines; D002250:Carbon Radioisotopes; D003470:Culture Media; D006595:Hexosamines; D005947:Glucose; D003630:Daunorubicin
Izuchenie biosinteza uglevodnogo fragmenta rubomitsina