[Effects of Etomidate on ventilation and blood gases].
17 surgical patients, agent 49 to 87, are studied. Their anaesthetic induction was performed by an intravenous injection of Etomidate on a 0,23 mg/kg body weight basiis. Respiratory frequency and minute ventilation were put on continuous recording, PO2, PCO2 and arterial blood pH were measured 1,3 and 5 minutes after injection of the drug. Anaesthetic induction, occuring 10 seconds after injection of the drug, was followed by an increase in respiratory frequency (32 p 100) and a rather modest increase of minute ventilation (9,2 p. 100). Among blood gases measurements, only PaO2 showed a decrease of 6,7 p. 100, when PO2 and pH remained practically unchanged. The small increase in minute ventilation, compared with a relatively important increase in respiratory frequency, suggests some decrease in efficient alveolar ventilation without however affecting blood gases in an important fashion.
D000368:Aged; D000771:Anesthesia, Intravenous / Q000379:methods*; D002245:Carbon Dioxide / Q000097:blood*; D004341:Drug Evaluation; D005045:Etomidate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D012119:Respiration / Q000187:drug effects*
D007093:Imidazoles; D002245:Carbon Dioxide; D010100:Oxygen; D005045:Etomidate
Effects de l'étomidate sur la ventilation  et les gaz du sang