Synthetic MIF has no effect on beta-MSH and ACTH hypersecretion in Nelson's syndrome.
The effect of synthetic MIF (H-Pro-Leu-Gly-NH2) on beta-MSH secretion was studied in five patients with Nelson's syndrome and in one patient with Addison's disease. Two milligrams of the tripetide were injected intravenously (1 mg in an acute injection, followed by a 30-minute-infusion of 1 mg in 20 ml of saline solution). No consistent effect could be observed during the 90-minute period after the beginning of the infusion. In the same patients, LVP stimulation and dexamethasone suppression tests brought about significant changes in the plasma beta-MSH and ACTH levels.
D000224:Addison Disease / Q000097:blood / Q000188:drug therapy; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D009075:MSH Release-Inhibiting Hormone / Q000627:therapeutic use*; D009074:Melanocyte-Stimulating Hormones / Q000097:blood*; D010911:Pituitary Neoplasms / Q000097:blood / Q000188:drug therapy*
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D009075:MSH Release-Inhibiting Hormone