Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives.
Twenty-five metabolites (purines, pyrimidines, nucleosides and nucleosides) were tested for their simultaneous action with 6-azauridine (AzUrd) in inhibition of Newcastle disease virus (NDV) replication. With the exception of deoxyadenosine and cyclic AMP all natural adenine derivatives exerted a synergic effect with AzUrd like ATP. Glutamine in combination with AzUrd did not inhibit NDV replication. The inhibitory effect of the combination of AzUrd and adenine derivatives was reversible by guanosine, uridine and cytidine but not by orotic acid or orotidylic acid.
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001380:Azauridine / Q000494:pharmacology*; D046508:Culture Techniques; D004357:Drug Synergism; D009522:Newcastle disease virus / Q000254:growth & development*; D009963:Orotic Acid / Q000494:pharmacology; D011684:Purine Nucleosides / Q000494:pharmacology; D011685:Purine Nucleotides / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000494:pharmacology; D011742:Pyrimidine Nucleotides / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D011684:Purine Nucleosides; D011685:Purine Nucleotides; D011741:Pyrimidine Nucleosides; D011742:Pyrimidine Nucleotides; D009963:Orotic Acid; D001380:Azauridine; D000225:Adenine