[Preventive action of catecholamine and serotonin synthesis inhibitors and of adrenergic blockaders on the occurrence of the anovular syndrome in neonatally androgenized rats. I].
Administration of catecholamine synthesis inhibitors (alpha-methl-p-tyrosine) or serotonin (parachlorphenylalanine) simultaneously with testosterone propionate prevented the anovular sterility in the majority of the neonatally androgenized rats. Preventive action of adrenoblockers (droperidol and propranolol) on the effects of early androgenization were weak. The data obtained pointed to the participation of catecholamines and serotonin in the realization of the masculinizing action of androgen on the neuroendocrine centres of the gonadotropin hormones secretion control.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000858:Anovulation / Q000517:prevention & control*; D002395:Catecholamines / Q000037:antagonists & inhibitors*; D004329:Droperidol / Q000627:therapeutic use; D004971:Estrus / Q000187:drug effects; D005260:Female; D010134:Fenclonine / Q000627:therapeutic use; D007247:Infertility, Female / Q000517:prevention & control; D008781:Methyltyrosines / Q000627:therapeutic use; D011247:Pregnancy; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D012733:Sex Differentiation / Q000187:drug effects; D013577:Syndrome; D013739:Testosterone / Q000008:administration & dosage; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D008781:Methyltyrosines; D012702:Serotonin Antagonists; D013739:Testosterone; D011433:Propranolol; D004329:Droperidol; D010134:Fenclonine
Preventivnoe deĭstvie ingibitorov sinteza katekholaminov, serotonina i adrenblokatorov na vozniknovenie anovuliatornogo sindroma u neonatal'no androgenizirovannykh krys. Soobshchenie I.