The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
The ability of several non-steroidal acidic anti-inflammatory drugs to cause ulceration when given as copper complexes has been examined. The damage caused by clopirac, niflumic acid and aspirin was virtually abolished when they were given as copper complexes whereas the damage caused by indomethacin, ketoprofen and (+)-naproxen was unaltered. The lack of ulceration with three of these preparations appeared to be correlated with a much reduced ability to inhibit prostaglandin synthesis as determined using an in vitro enzyme system.
D000085:Acetates; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001241:Aspirin / Q000031:analogs & derivatives; D002614:Chelating Agents; D003300:Copper / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000031:analogs & derivatives; D007660:Ketoprofen / Q000031:analogs & derivatives; D008297:Male; D009288:Naproxen / Q000031:analogs & derivatives; D009544:Niflumic Acid / Q000031:analogs & derivatives; D010437:Peptic Ulcer / Q000139:chemically induced*; D011458:Prostaglandins E / Q000096:biosynthesis; D011758:Pyrroles; D051381:Rats
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002614:Chelating Agents; D011458:Prostaglandins E; D011758:Pyrroles; D009544:Niflumic Acid; D009288:Naproxen; D003300:Copper; D007660:Ketoprofen; D001241:Aspirin; D007213:Indomethacin