Effects in the rat of intradermal injection of purified proteinases from streptococcus and Serratia marcescens.
Purified streptococcal proteinase and Serratia proteinase are potent permeability factors in rat skin and initiate histopathological evidence of an acute inflammatory response. These effects appear to be largely independent of terminal components of complement, histamine, and polymorphonuclear leukocytes.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D003165:Complement System Proteins / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D009504:Neutrophils / Q000473:pathology; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D012702:Serotonin Antagonists; D012705:Serratia / Q000201:enzymology; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000201:enzymology
D006634:Histamine H1 Antagonists; D012702:Serotonin Antagonists; D003165:Complement System Proteins; D010447:Peptide Hydrolases