Prevention of experimental gastric ulcers in rats by dial derivatives.
In 111 rats divided into 5 groups, Ipronal (5-allyl-5-(beta-hydroxypropyl)-barbituric acid) protected rats from development of experimental ulceration of the gastric mucosa twice as effectively as diallylbarbituric acid and compound D2H (5-isopropyl-5-(beta-hydroxypropyl)-barbituric acid). Compound D1S (alpha-allophanyl-alpha-allyl-gamma-valerolactone) was devoid of this action.
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects; D001463:Barbiturates / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000294:innervation; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*
D001463:Barbiturates