[Relationship between glycolysis and pentose cycle intensity and thrombocyte aggregation induced by ADP in man].
Aggregation of thrombocytes, caused by ADP, affected the rate of anaerobic breakdown of carbohydrates due to inhibition of the glucose degradation, while the rate of lactate formation was not distinctly altered. Content of NAD was decreased simultaneously with an increase in content of NADP; the activity of glucose-6-phosphate dehydrogenase was distinctly increased but the unaltered activity of 6-phosphogluconate dehydrogenase was observed; content of reduced glutathione was increased 15-fold. The activity of NADP-dependent glutathione reductase was increased under effect of ADP; at the same time, the activity of NAD-dependent glutathione reductase did not depend on the diphosphate effect.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010428:Pentosephosphates / Q000378:metabolism*; D010974:Platelet Aggregation
D010428:Pentosephosphates; D009243:NAD; D009249:NADP; D000244:Adenosine Diphosphate; D005980:Glutathione Reductase; D005978:Glutathione
Zavisimost' intensivnosti glikoloza i pentoznogo tsikla ot agregstsii trombotsitov cheloveka, vyzvannoĭ ADF.