Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction.
With use of a canine model of occlusion of the left anterior descending coronary artery and an intracellular lactic dehydrogenase stain to measure infarct size directly, the effects of allopurinol, methylprednisolone sodium succinate and propranolol were studied. Allopurinol did not influence the extent of myocardial necrosis, whereas both methylprednisolone and propranolol significantly reduced myocardial infarct size. Possible mechanisms of action and clinical applicability of these agents are discussed.
D000493:Allopurinol / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001769:Blood; D003327:Coronary Disease / Q000188:drug therapy; D004195:Disease Models, Animal; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008775:Methylprednisolone / Q000494:pharmacology* / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
D000493:Allopurinol; D011433:Propranolol; D010100:Oxygen; D008775:Methylprednisolone