Effects of dietary vitamin D and calcium on lysyl oxidase activity in chick bone metaphyses.
Activity of lysyl oxidase, an enzyme responsible for production of aldehydic precursors for lysine-derived collagen crosslinks, was measured in tibial metaphyses from chicks receiving different dietary levels of vitamin D and Ca for 2 weeks after hatching. Enzyme activities were increased twofold in D-deficient chicks compared to activities from chicks receiving control levels of vitamin D. Addition of Ca to the D-deficient diet had no effect on lysyl oxidase activity. It is suggested that vitamin D may play a role in the age-related decrease in lysyl oxidase activity that normally occurs in chick bone.
D000367:Age Factors; D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000201:enzymology; D001842:Bone and Bones / Q000201:enzymology*; D002118:Calcium / Q000097:blood / Q000494:pharmacology*; D002645:Chickens; D008297:Male; D010710:Phosphates / Q000097:blood; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*; D014807:Vitamin D / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000201:enzymology
D010710:Phosphates; D014807:Vitamin D; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase; D002118:Calcium