Anticholinesterase activity of some butyrophenones.
The anticholinesterase (antiChE) activity of haloperidol, droperidol and trifluperidol was studied by employing dog plasma as a cholinesterase source and changes in arterial blood pressure, elecited by a mixture of acetylcholine (Ach) and dog plasma with or without those drugs, as an indicator of their antiChE activity. When butyrophenones were present in concentrations of 0.5 up to 5 X 10(-4)M in plasma containing Ach the hypotensive effect of the latter was preserved. Such findings provide experimental evidence that butyrophenones may exert antiChE activity.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002090:Butyrophenones; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood; D004285:Dogs; D005260:Female; D008297:Male
D014150:Antipsychotic Agents; D002090:Butyrophenones; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases; D000109:Acetylcholine