[Methylmalonic acid excretion in experimental B2-avitaminosis in rats].
Providing of rats with a diet, deficient in vitamin B2 within 2 and 5 weeks, was not shown to be accompanied by an increase in excretion of methylmalonic acid. In the animals some tendency to the increased excretion of methylmalonic acid was observed within 8 weeks of the diet. The data obtained suggest that the test for excretion of methylmalonic acid was the highly specific as a pattern of supply with vitamin B12. The possible role of vitamin B2 and flavoproteins in biosynthesis of coenzyme forms of vitamin B12 is discussed.
D000818:Animals; D004032:Diet; D004789:Enzyme Activation; D005182:Flavin-Adenine Dinucleotide; D005980:Glutathione Reductase / Q000097:blood; D008314:Malonates / Q000652:urine*; D008764:Methylmalonic Acid / Q000652:urine*; D008765:Methylmalonyl-CoA Mutase / Q000378:metabolism; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D012257:Riboflavin Deficiency / Q000201:enzymology / Q000652:urine*; D013997:Time Factors
D008314:Malonates; D011422:Propionates; D005182:Flavin-Adenine Dinucleotide; D008764:Methylmalonic Acid; D005980:Glutathione Reductase; D008765:Methylmalonyl-CoA Mutase
Ekskretsiia metilmalonovoĭ kisloty pri éksperimental'nom B2-avitaminoze u krys