Clinical usefulness of the beta-adrenergic antagonists.
The pharmacology of the beta-adrenergic antagonists, particularly their role as competitive antagonists at the receptor site, is discussed. The clinical use of these agents is listed and a detailed outline of their use in angina pectoris, hypertension and conditions associated with increased sympathetic activity is provided. The relative contraindications to the use of beta-adrenergic antagonists are summarized and the pharmacology of those drug interactions involving these agents is discussed. A thorough understanding of the pharmacology and therapeutics of these agents, which interfere with physiological function, is mandatory prior to their clinical use.
D000318:Adrenergic beta-Agonists / Q000502:physiology; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001281:Atrial Fibrillation / Q000188:drug therapy; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy; D002450:Cell Communication; D002468:Cell Physiological Phenomena; D055598:Chemical Phenomena; D002621:Chemistry; D000242:Cyclic AMP / Q000096:biosynthesis; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D006980:Hyperthyroidism / Q000188:drug therapy; D007545:Isoproterenol; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy; D010673:Pheochromocytoma / Q000188:drug therapy; D011247:Pregnancy / Q000187:drug effects; D011433:Propranolol / Q000502:physiology; D011802:Quinidine / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D011433:Propranolol; D000242:Cyclic AMP; D007548:Isosorbide Dinitrate; D011802:Quinidine; D007545:Isoproterenol; D004837:Epinephrine