Glutamine synthetase: glial localization in brain.
Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.
D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D007124:Immunoenzyme Techniques; D009457:Neuroglia / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D000641:Ammonia; D005974:Glutamate-Ammonia Ligase