Metabolic acidosis after hyperalimentation with casein hydrolysate. Occurrence in a starved patient.
A 29-year-old woman with short bowel syndrome and prolonged starvation developed hyperchloremic metabolic acidosis after initiation of hyoeralimentation with a casein hydrolysate solution. The acidosis was not due to bicarbonate loss but was associated with diminished ability of the kidney to increase urinary acid excretion, particularly titratable acidity. Supplemental parenteral bicarbonate administration was necessary for two weeks until urinary acid excretion rose to normal.
D000138:Acidosis / Q000150:complications / Q000209:etiology*; D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D002364:Caseins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D011183:Postoperative Complications; D011247:Pregnancy; D013217:Starvation / Q000150:complications / Q000652:urine
D001639:Bicarbonates; D002364:Caseins