Prevention and treatment of premature labour by drugs: review of controlled clinical trials.
This review sought evidence from 18 controlled clinical trials about the benefits of drugs (hormones, ethanol or beta-sympathomimetic agents) used to prevent premature birth. Of the 16 trials comparing drug with placebo, 13 were judged to be methodologically adequate. In eight trials, drugs were given prophylactically and in five they were given therapeutically. Two of the therapeutic trials found the drug more effective than placebo in postponing delivery. However, only one therapeutic trial and one prophylactic trial found the drug to affect favourably the outcome for the infant. The side effects of the drugs were not systematically studied. Additional clinical trials are needed to justify the use of drugs to inhibit labour.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D001724:Birth Weight; D002986:Clinical Trials as Topic; D000431:Ethanol / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D012739:Gonadal Steroid Hormones / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy* / Q000517:prevention & control; D011247:Pregnancy; D012107:Research Design
D000318:Adrenergic beta-Agonists; D012739:Gonadal Steroid Hormones; D000431:Ethanol