Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones.
The synthesis and CNS activity of a noval class of annelated 1,4-benzodiazepines, the aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepines, are described. An investigation of the structure--activity relationships in the series derived from 8-chloro-2,4-dihydro-2-dimethylaminomethylene-6-phenyl-1H-imidazo[1,2-a][1,4]-benzodiazepin-1-one (10) led to the synthesis of a group of compounds with potent minor tranquillizer activity.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000633:toxicity; D000927:Anticonvulsants / Q000138:chemical synthesis; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002749:Chlorprothixene / Q000494:pharmacology; D004357:Drug Synergism; D004597:Electroshock; D006591:Hexobarbital / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D013331:Strychnine / Q000037:antagonists & inhibitors
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D002749:Chlorprothixene; D006591:Hexobarbital; D013331:Strychnine; D010433:Pentylenetetrazole