The effects of HGCl2 and mersalyl on mechanisms regulating intracellular calcium and transmitter release.
HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transmitter release. These mercurials inhibited calcium transport of mitochondria and synaptosomal vesicles. Lower concentrations of HgCl2 showed a stimulatory effect on mitochondrial calcium uptake. It is suggested that the effect of mercurials on transmitter release is mediated via changes of the intracellular calcium ion concentration.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001001:Anura; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D066298:In Vitro Techniques; D008628:Mercury / Q000494:pharmacology*; D008634:Mersalyl / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009941:Organomercury Compounds / Q000494:pharmacology*; D011898:Ranidae; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D018377:Neurotransmitter Agents; D009941:Organomercury Compounds; D008634:Mersalyl; D000255:Adenosine Triphosphate; D008628:Mercury; D002118:Calcium