[Immunosuppressive role of the liver in the graft versus host reaction].
The ability of the liver to reduce the intensity of the graft versus host (GVH) reaction has been investigated in F1 hybrid rats implanted with parental lymph nodes. Intrahepatic and intrarenal tissue implantations were compared using classical GVH criteria. The intrahepatic implantation of lymph nodes suppress the mortality observed after intrarenal implantation. The results confirm the interest of portal drainage in organ transplantation and suggest a new site of implantation for lymphoid cells.
D000818:Animals; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D007165:Immunosuppression Therapy; D007668:Kidney / Q000276:immunology / Q000502:physiology; D008099:Liver / Q000276:immunology* / Q000502:physiology; D008198:Lymph Nodes / Q000637:transplantation*; D009929:Organ Size; D051381:Rats; D013154:Spleen; D013601:T-Lymphocytes / Q000502:physiology
D006649:Histocompatibility Antigens
Rôle immunosuppresseur du foie dans la réaction greffon contre fôte