The dynamic properties of biological membranes.
Biological membranes must be viewed as highly dynamic, undergoing continuous structural fluctuations and changes in response to external perturbations. The study of liposomes by 31 P n.m.r. and fluorescence can reveal some of the motional characteristics of the different regions in a bilayer. Asymmetric lipid distribution and how this depends on the environment is also observed by n.m.r. The nature of the interaction of amine anaesthetics and of polypeptide antibodies with membranes is discussed in relation to their perturbing effect. The role of lipid mobility in modulating hormone-receptor interaction is discussed with reference to the binding of thyroid stimulating hormone.
D010129:4-Aminobenzoic Acid / Q000378:metabolism; D002838:Chromaffin System / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008566:Membranes / Q000378:metabolism* / Q000648:ultrastructure; D008567:Membranes, Artificial; D009904:Optical Rotation; D010169:Palmitic Acids; D010713:Phosphatidylcholines / Q000378:metabolism; D011113:Polymyxins / Q000494:pharmacology; D011956:Receptors, Cell Surface; D013050:Spectrometry, Fluorescence; D013961:Thyroid Gland / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism
D008567:Membranes, Artificial; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D011113:Polymyxins; D011956:Receptors, Cell Surface; D013972:Thyrotropin; D010129:4-Aminobenzoic Acid