Demonstration of hemopoietic stem cells in the peripheral blood of baboons by cross circulation.
Baboons were given 1200 R total body irradiation from two opposing 60Co sources. Three animals were given supportive therapy only and died, as expected, within 8 days of irradiation with profound marrow hypoplasia. Five baboons were cross-circulated with unirradiated partners and died within 14 days with evidence suggestive of graft-versus-host disease. Their marrows were repopulated with hemopoietic precursor cells, and three of the five had rises in peripheral white blood cell counts to more than 1500/cu mm before death. These results are compatible with the presence of hemopoietic stem cells in the peripheral blood of a nonhuman primate, the baboon.
D000017:ABO Blood-Group System; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D003427:Cross Circulation; D006087:Graft vs Host Reaction; D000882:Haplorhini; D006412:Hematopoietic Stem Cells; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D010215:Papio / Q000097:blood*
D000017:ABO Blood-Group System