[The place of enflurane in neuro-anesthesia].
In neuro-anaesthesia, anaesthetic agents must be in accordance with certain criteria necessary to the preservation of the integrity of the brain. Therefore it was in such a perspective that we re-appraised the effects of enflurane upon cortical irritability, metabolism, cerebral blood flow and intracranial pressure. We reached the following conclusions: in normocapnia, and with optimal clinical concentrations, this drug remains the best anaesthetic agent since it has no harmful effect either upon metabolism or upon cerebral blood flow. However, in hypertensive cerebral lesions, caution is called for an it seems advisable to combine Enflurane with mild doses of fentanyl. Finally, anaesthesia with enflurane is followed by a rapid and smooth return to consciousness, a valuable factor in neurosurgery where post-operative neurological watching matters very much.
D000758:Anesthesia; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects; D004341:Drug Evaluation; D004737:Enflurane / Q000494:pharmacology / Q000592:standards*; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007427:Intracranial Pressure / Q000187:drug effects; D008738:Methyl Ethers / Q000592:standards*; D009493:Neurosurgery
D008738:Methyl Ethers; D004737:Enflurane; D005283:Fentanyl
Place de l'enflurane en neuro-anesthésie