A solution to the graft-versus-host problem in bone marrow transplantation to humans.
Many clinical situations arise where it would be desirable to transplant bone marrow to a marrow function deficient patient. However, bone marrow is immunologically competent by virtue of its content of lymphocyte precursors. Marrow transplantation in these patients is followed by the graft's immunological rejection of the patient - a fatal disease. A system for specific abrogation of this graft-versus-host disease after xenogeneic bone marrow transplantation to humans is presented. In this system, prospective patient cells are removed by skin biopsy for example, and injected into a fetal chimpanzee. The fetal chimpanzee becomes tolerant to this patient's antigens and will not attack or reject them when its bone marrow is removed after birth and injected into the specific patient from whom the tolerogenic cells were obtained. A simple and straightforward experimental test of this system's clinical applicability is also presented.
D000818:Animals; D016026:Bone Marrow Transplantation; D005333:Fetus / Q000276:immunology; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D006801:Humans; D002679:Pan troglodytes; D014183:Transplantation, Heterologous / Q000379:methods