Gastric mucus effusion elicited by oral copper compounds: potential anti-ulcer activity.
In rats, both Cu(I) and Cu(II) show an irritancy profile not shared with Cu degrees or Zn(II) or Ni(II). The gastric response to Cu(II), i.e. copius fluid and mucus secretion, can protect the stomach from the acute ulcerative effects of aspirin or physical stress administered subsequently.
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin; D003300:Copper / Q000008:administration & dosage / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced; D005260:Female; D005528:Foot; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006614:Hindlimb; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008297:Male; D009093:Mucus / Q000378:metabolism*; D051381:Rats; D013217:Starvation; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications
D008024:Ligands; D003300:Copper; D001241:Aspirin