[Optimal dosage in peroral therapy of acne with vitamin A palmitate].
Successful oral therapy with vitamin A palmitate in acne vulgaris requires 150,000-200,000 I.U. daily for months. Side-effects were evaluated in 22 patients and in addition in 54 patients receiving 400,000 and 300,000 I.U. respectively for 3-4 weeks (SGPT, GGPT, Quick, electrophoresis, creatinine, bromosulfthaleine excretion). The same tests were done in 32 patients, who had received vitamin A palmitate 150,000-200,000 I.U. daily for at least half a year. Clinical experience and the presented data allow the following conclusions: There is no risk of liver impairement when 150,000-200,000 I.U. are given daily over extended periods. Doses over 300,000 I.U. are accompanied with liver impairement. During long-term treatment y-GT test should be performed regularly. Contraceptive advices are recommended.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008111:Liver Function Tests; D008134:Long-Term Care; D013448:Sulfobromophthalein; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000097:blood
D013448:Sulfobromophthalein; D014801:Vitamin A; D005723:gamma-Glutamyltransferase
Zur optimalen Dosierung einer peroralen Therapie der Akne mit Vitamin-A-Palmitat