The action of colloidal silicon dioxide as a glidant for lactose, paracetamol, oxytetracycline and their mixtures.
Anomalies are observed in some of the physical and mechanical properties of mixtures of lactose, paracetamol and oxytetracycline when small amounts of colloidal silicon dioxide are added to them. Owing to its differing propensities to coat the particles of the host powders, the silicon dioxide acts as a glidant for the lactose and paracetamol, but as an antiglidant for the oxytetracycline.
D000082:Acetaminophen; D003102:Colloids; D004338:Drug Combinations; D005079:Excipients; D007785:Lactose; D010118:Oxytetracycline; D010316:Particle Size; D014677:Pharmaceutical Vehicles; D011208:Powders; D012822:Silicon Dioxide; D013997:Time Factors
D003102:Colloids; D004338:Drug Combinations; D005079:Excipients; D014677:Pharmaceutical Vehicles; D011208:Powders; D000082:Acetaminophen; D012822:Silicon Dioxide; D007785:Lactose; D010118:Oxytetracycline