'Picture frame' fibres in a carrier of the trait for malignant hyperpyrexia.
A member of a family which was known to be susceptible to malignant hyperpyrexia, who was identified as a carrier by the presence of an elevated serum creatine-phosphokinase, has been investigated further. Muscle was examined biochemically, and the study included the sarcoplasmic ATPase-activity, actinomycin, Mg2+ ATPase activity, ATP, phosphocreatine and glucose-6-phosphate. In addition, the calcium uptake by the sarcoplasmic reticulum was studied. The histochemical analysis of the muscle revealed the presence of a new fibre type characterised by a dense rim of ATPase activity, which gives the impression of a 'picture-frame'. Ultramicroscopic study revealed changes in the mitochondria and areas of myofibrillar disruption with swelling of the sarcoplasmic reticulum.
D000251:Adenosine Triphosphatases / Q000032:analysis*; D000328:Adult; D002118:Calcium / Q000378:metabolism; D006221:Halothane / Q000494:pharmacology; D006579:Heterozygote; D006651:Histocytochemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008305:Malignant Hyperthermia / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D008854:Microscopy, Electron; D008928:Mitochondria; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000201:enzymology* / Q000473:pathology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D000251:Adenosine Triphosphatases; D002118:Calcium; D006221:Halothane