Further characterization of morphine-like peptides (endorphins) from pituitary.
Pituitary peptides with opioid pharmacologic action (endorphins) can exist in several forms with different basicities and molecular weights from about 3000 to less than 1000 daltons. Partial purification yielded an endorphin at least 4 times more potent than normorphine and 16 times more potent than the endogenous brain pentapeptide methionine enkephalin. It is proposed that pituitary endorphin or a similar peptide in brain may be the precursor of brain enkephalin.
D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D001921:Brain; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D007082:Ileum / Q000187:drug effects; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D008970:Molecular Weight; D009270:Naloxone / Q000494:pharmacology; D010455:Peptides / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D011869:Radioligand Assay; D011957:Receptors, Opioid / Q000378:metabolism
D010455:Peptides; D011957:Receptors, Opioid; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones