Effects of palytoxin on the electrical activity of dog and rabbit heart.
Reversible effects of palytoxin, extracted from colonies of the soft coral Palythoa caribaeorum, are described. There is a decrease of both membrane resting potential and overshoot during activity. Rise time of the action potential is prolonged, while repolarization is shortened. The electrical events resemble those seen with metabolic poisons.
D000178:Acrylamides; D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D003064:Cnidarian Venoms / Q000494:pharmacology*; D004285:Dogs; D008564:Membrane Potentials / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects*; D011817:Rabbits; D000095702:Polyether Toxins
D000178:Acrylamides; D003064:Cnidarian Venoms; C010272:palytoxin; D000095702:Polyether Toxins