[Interaction of morphocycline with beryllium ions].
Behaviour of morphocycline (H5R) and its complex with beryllium ions in acqueous solutions was studied fluorimetrically. The ionization constants of H5R were estimated at pH 1.5-15 according to the data of fluorimetric determination with respect to OH-group: pK1 6.40, pK2 8.25, pK3 10.65, pK4 11.30. Two constants characterizing the deprotonization process with respect to the carbonylic group and nitrogen were also estimated: pK01--1.0 (greater than C = 0) and pK02 4.75 (--N=). Formation of an intensively fluorescing compound less than [Be3(OH)3(H2O2)5]2HR greater than 2+ was observed at pH 6.0-7.0. The cause of such intensive fluorescence was deformation of ion [Be3(OH)3(H2O)6]3+ because of its exclusion from the coordinating sphere of one molecule of water during the complex formation and decreasing of level H comes from II as compared to the morphocycline level II comes from n. A procedure for detecting morphocycline in the blood of humans and animals was developed.
D000818:Animals; D001608:Beryllium / Q000494:pharmacology*; D004347:Drug Interactions; D005453:Fluorescence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013754:Tetracyclines / Q000097:blood / Q000494:pharmacology*
D007477:Ions; D012996:Solutions; D013754:Tetracyclines; D001608:Beryllium
Vzaimodeĭstvie morfotsiklina s ionami berilliia