Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data.
Fifteen acidic antiinflammatory agents, for which some clinical data have previously been published, have been examined for their potency in the carrageenan-induced rat foot edema test, and for their acidity (pKa) and partition coefficients. Published serum half-life data and daily clinical (anti-arthritic) dose have been tabulated for these drugs and correlations between these various parameters are discussed. The rat foot edema carrageenan test has proved to be a fairly reliable predictor of clinical dose for most acidic antiinflammatory agents of moderate serum half-life.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000627:therapeutic use; D002351:Carrageenan; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006207:Half-Life; D006614:Hindlimb; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D002351:Carrageenan