A model independent method for estimating the in vivo release rate constant of a drug from its oral formulations.
A simple equation by which the first-order release rate constant of a drug from its oral formulation can be calculated is derived. The derivation is independent of any hypothetical concepts of drug distribution or elimination.
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D008694:Methamphetamine; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D012995:Solubility
D004364:Pharmaceutical Preparations; D008694:Methamphetamine