[Use of acetylcholinesterase reactivators and central cholinolytics in the treatment of experimental tetanus poisoning].
Experiments were conducted on rabbits with tetanus intoxication induced by the intravenous injection of a lethal dose of the toxin; a study was made of the therapeutic efficacy of the acetylcholinesterase reactivators--dipyroxim and isonitrosine, and also of the central cholinolytics--amizyl and diphacyl. In dose of 25 mg/kg dipyroxim produced no therapeutic effect, and in doses of 30--40 mg/kg caused the animal death. Amizyl and diphacil in a dose of 3--4 mg/kg caused elimination of tonic convulsions for 1 1/2--2 hours. As to isonitrosin--it produced the same effect for 4--5 hours. In case of combined administration of reactivators and cholinolytics convulsions were eliminated for 4--5 hours.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001535:Benactyzine / Q000627:therapeutic use; D002074:Butanones / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D004158:Diphenylacetic Acids / Q000627:therapeutic use; D005260:Female; D008297:Male; D009044:Motor Cortex / Q000201:enzymology; D009046:Motor Neurons / Q000201:enzymology; D010276:Parasympatholytics / Q000627:therapeutic use*; D011817:Rabbits; D013116:Spinal Cord / Q000201:enzymology; D013742:Tetanus / Q000188:drug therapy* / Q000201:enzymology; D014289:Trimedoxime / Q000627:therapeutic use
D002074:Butanones; D002801:Cholinesterase Reactivators; D004158:Diphenylacetic Acids; D010276:Parasympatholytics; D014289:Trimedoxime; D001535:Benactyzine; D000110:Acetylcholinesterase
Primenenie reaktivatorov atsetilkholinésterazy i tsentral'nykh kholinolitikov pri lechenii éksperimental'noĭ stolbniachnoĭ intoksikatsii.