Distribution of camazepam in rats and mice.
Camazepam, 5 mg/kg iv, was injected in rats and mice to study its distribution in the blood and brain. Peak blood levels were about 0.9 microgram/ml in rats and 0.6 microgram/ml in mice. Peak brain levels were about 1.5 microgram/g in rats and 0.8 microgram/g in mice. The apparent blood half-life of camazepam was 9 min in mice and 20 min in rats.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas / Q000379:methods; D008297:Male; D051379:Mice; D051381:Rats; D013045:Species Specificity; D013693:Temazepam / Q000097:blood / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D013693:Temazepam