Effect of hydrazine, isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine on guanylate cyclase activity.
The chemical carcinogen hydrazine is a potent stimulator of guanylate cyclase. In the present investigation we found that three chemical carcinogens structurally related to hydrazine, isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine, decreased guanylate cyclase activity. It is of interest that hydrazine has been shown to increase DNA synthesis whereas isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine decrease DNA synthesis. The relationship, if any, linking the guanylate cyclase-cyclic GMP system to DNA synthesis and carcinogenesis remains to be explored.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D051381:Rats
D002273:Carcinogens; D004127:Dimethylhydrazines; D006834:Hydrazines; D006162:Guanylate Cyclase; D007538:Isoniazid