Effects of benzodiazepines on the binding of tryptophan in serum. Consequences on 5-hydroxyindoles concentrations in the rat brain.
Benzodiazepines (diazepam, oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin. As a result, in vivo treatment with one of these compounds (chlordiazepoxide for instance) induced a significant increase in the concentration of free tryptophan in serum. These observations suggest that the high levels of both 5-hydroxyindoles and tryptophan which occurred in the rat brain after any benzodiazepine administration could be at least partly the consequence of its effect on tryptophan binding in blood.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D066298:In Vitro Techniques; D007211:Indoles / Q000032:analysis*; D008297:Male; D010076:Oxazepam / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D014364:Tryptophan / Q000097:blood*; D014443:Tyrosine / Q000097:blood
D000596:Amino Acids; D014151:Anti-Anxiety Agents; D007211:Indoles; D012709:Serum Albumin; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D010076:Oxazepam; D002707:Chlordiazepoxide; D014364:Tryptophan; D003975:Diazepam