[Levamisole, a chemically defined substance with immunostimulating potential--a review].
In contrast to immunosuppression, immunostimulation is still at an early stage of development. Levamisole is the first chemically defined substance with immunostimulating potential which can be applied systemically. After a short consideration of the chemistry and pharmacology of Levamisole, its effect in different animal experimental models of humoral and cell-mediated immunity are discussed in detail. Moreover, the following review deals with the influence of Levamisole on several immunological parameters in man. Finally, the therapeutical results achieved up to now by different clinical indications are reported.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D004352:Drug Resistance, Microbial; D006087:Graft vs Host Reaction / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007978:Levamisole / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects
D007978:Levamisole
Levamisol, Eine chemisch definierte, immunpotenzierende Substanz - Eine Ubersicht