[Cardiotoxicity of bromethylbutyramide (carbromide) (author's transl)].
Bromethylbutyramide (Carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. The negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poisoning. The cardiodepressive actions of bromethylbutyramide and carbromal may be important for the course and the ending of severe carbromal intoxications.
D000818:Animals; D003864:Depression, Chemical; D004558:Electric Stimulation; D000431:Ethanol / Q000494:pharmacology; D006168:Guinea Pigs; D006331:Heart Diseases / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D014508:Urea / Q000009:adverse effects / Q000031:analogs & derivatives*
D000431:Ethanol; C017835:carbromide; D014508:Urea
Kardiotoxizität von Carbromid.