Isolation and characterization of a neuroblastoma cell line from peripheral blood in a patient with disseminated disease.
Circulation in the blood stream of neuroblastoma cells was confirmed by establishment of a cell line from the peripheral blood of a child with disseminated disease. The morphologic, enzymatic, and chromosomal pattern of this cell line was similar to a cell line established from the primary tumor on a previous occasion. The peripheral blood smear did not demonstrate tumor cells but increased numbers of atypical monocytes; lymphoblasts were evident, which may have been unrecognized neuroblasts.
D000110:Acetylcholinesterase / Q000378:metabolism; D002460:Cell Line; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D009360:Neoplastic Cells, Circulating; D009447:Neuroblastoma / Q000201:enzymology / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase