[Peculiarities of aggregation in acid medium of immunoglobulin G peculiar to cancer].
Immunoglobulin G peculiar to cancer under the effect of acid medium changes to a slightly soluble form due to reversible formation of aggregates. The rest serum proteins transfer to the insoluble form in a more acid medium due to the irreversible denaturation changes in the protein molecules. When isolating aggregates of the mentioned protein from the blood serum of patients with cancer it is impossible to differ these sera from those of donors or patients with pathologies of nonmalignant character under the effect of acid medium. The amount of the aggregates isolated accounts for 1.1-1.2% of total amount of serum proteins and does not depend on affinity of the anion of acid in the presence of which the experiment was conducted for proteins.
D000951:Antigens, Neoplasm; D001798:Blood Proteins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000302:isolation & purification*; D009369:Neoplasms / Q000097:blood*; D011489:Protein Denaturation; D012995:Solubility
D000951:Antigens, Neoplasm; D001798:Blood Proteins; D007074:Immunoglobulin G
Osoblivosti agregatsii imunoglobulinu G, kharakternogo dlia raku, v kislomu seredovishchi.