[Factors causing lysis of an Actinomyces rimosus culture, the producer of the antibiotic, oxytetracycline].
The lysis of Actinomyces rimosus producing oxytetracycline during its mass growth can be caused by two factors which were separated by differential centrifugation. The first factor is phage particles of a temperate phage produced by the culture; they are incapable of growth but may induce the lysis. The phage particles treated with low pH and a temperature of 70 degrees C lose the lytic activity. The second factor is a lytic enzyme produced under the control of the temperate phage during its induction; it seems to consist of at least two enzymes, a lytic enzyme and a proteolytic enzyme.
D001433:Bacteriolysis; D001435:Bacteriophages / Q000201:enzymology / Q000302:isolation & purification; D002455:Cell Division; D002498:Centrifugation; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003470:Culture Media; D004790:Enzyme Induction; D006863:Hydrogen-Ion Concentration; D010118:Oxytetracycline / Q000096:biosynthesis*; D013302:Streptomyces; D013696:Temperature
D003470:Culture Media; D010118:Oxytetracycline
O faktorakh, vyzyvaiushchikh lizis kul'tury Actinomyces rimosus-produtsenta antibiotika oksitetratsiklina