Activation of hepatic guanylate cyclase by N-methyl-N'-nitro-N-nitrosoguanidine. Effects of thiols, N-ethylmaleimide, and divalent cations.
D000693:Anaerobiosis; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005033:Ethylmaleimide / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D008769:Methylnitronitrosoguanidine; D008345:Manganese; D006162:Guanylate Cyclase; D005978:Glutathione; D008274:Magnesium; D003545:Cysteine; D005033:Ethylmaleimide; D001205:Ascorbic Acid; D004229:Dithiothreitol