[Effect of the antibiotic D-cycloserine and its dimer on the activity of tyrosine aminotransferase in liver tissue of intact, adrenalectomized and hypophysectomized rats].
In a period of lowest day activity of tyrosine aminotransferase, within 6-8 days after bilatheral adrenalectomy, the enzyme activity was decreased by about 20% as compared with an adequate control. At the same time, within a day and seven days after hypophisectomy, in rat liver tissue the enzyme activity was increased, approximately two-fold as compared with the normal state. Within four hrs after intraperitoneal administration into intact fasting rats at a dose of 2-2.5 g per 1 kg of body weight D-cycloserine and its dimer caused an induction of tyrosine aminotransferase by 75% and 180%, respectively. Induction of the enzyme by D-cycloserine and its dimer was inhibited by actinomycin D; the phenomenon was not observed in adrenalectomized rats. Within a day after hypophisectomy D-cycloserine did not cause the induction of tyrosine aminotransferase in rat liver tissue; to the contrary, the dimer of D-cycloserine caused induction of the enzyme, comparable to the ACTH effect, in liver tissue of hypophisectomized rats.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003523:Cycloserine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D007016:Hypophysectomy; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D014444:Tyrosine Transaminase / Q000378:metabolism*
D000324:Adrenocorticotropic Hormone; D003523:Cycloserine; D014444:Tyrosine Transaminase
Vliianie antibiotika D-tsikloserina i ego dimera na aktivnost' tirosin-aminotransferazy v pecheni intaktnykh, adrenalektomi-rovannykh ili gipofizektomirovannykh krys