The effect of anti-inflammatory and antirheumatic drugs on inflammation in the rat.
The anti-inflammatory effects of flurbiprofen and a number of other antirheumatic agents were studied in the rat using a model of inflammation, which involved the subcutaneous implantation of polyurethane cubes impregnated with an irritant. Results of acute and chronic studies indicated that flurbiprofen was extremely effective in suppressing both fluid and cellular phases of inflammation and, in this model, was comparable in potency to prednisolone.
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents; D002908:Chronic Disease; D004195:Disease Models, Animal; D005122:Exudates and Transudates / Q000166:cytology; D005480:Flurbiprofen / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy*; D010648:Phenylacetates / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D011422:Propionates / Q000627:therapeutic use*; D051381:Rats; D012216:Rheumatic Diseases / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D010648:Phenylacetates; D011422:Propionates; D005480:Flurbiprofen; D011239:Prednisolone