Bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. Part 2: pharmacology.
1-(7-Ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane hydrochloride (bufuralol) is a non-selective beta-adrenoceptor blocking agent which closely resembles propranolol in its properties, including potency. Bufuralol is devoid of alpha-adrenoceptor blocking activity but possesses beta-adrenoceptor agonist activity. beta-Adrenoceptor blocking activity resides mainly in the (-)-isomer though membrane stabilising properties are associated with both optical isomers.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects; D000779:Anesthetics, Local; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002415:Cats; D004285:Dogs; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D010042:Ouabain / Q000037:antagonists & inhibitors; D011817:Rabbits; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013045:Species Specificity; D013564:Sympathetic Nervous System / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D000779:Anesthetics, Local; D001572:Benzofurans; D004983:Ethanolamines; D011943:Receptors, Adrenergic, beta; D010042:Ouabain; D006003:Glycogen