Determination of lorazepam in plasma by electron capture GLC.
A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. The limit of detection is 0.01 mg/l and the assay shows a linearity from 0.01-0.80 mg lorazepam per liter of plasma.
D014151:Anti-Anxiety Agents / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D004355:Drug Stability; D006358:Hot Temperature; D006801:Humans; D008140:Lorazepam / Q000097:blood*; D013058:Mass Spectrometry; D008968:Molecular Conformation
D014151:Anti-Anxiety Agents; D008140:Lorazepam