Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods.
The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measurement of the peak height ratios, 1775/1618 and 3095/1618 cm-1. Correlation between results obtained by the two methods is good. These methods are of value in the physico-chemical characterization of digoxin, particularly as the properties may be altered by comminution.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D003461:Crystallography; D004077:Digoxin / Q000032:analysis; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D004077:Digoxin