[Antihemolytic effect of various benzodiazepines on human erythrocytes].
The benzodiazepines, medazepam, chlorodiazepoxyde, and oxazepam, act antihemolytically just as chloropromazine in hypotonic NaCl solution on human erythrocytes. The effect depends on concentration and is biphasic with the exception of oxazepam. The maximal antihemolytic concentrations are for medazepam 9.1-10-5 M, for chlorodiazepoxyde 4.6-10-4 M and, respectively, 9.1-10-4 M for diazepam and oxazepam. No linear correlation exists between the concentration at maximal hemolytic protection and the lipid solubility.
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008472:Medazepam / Q000494:pharmacology; D010076:Oxazepam / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D010076:Oxazepam; D002707:Chlordiazepoxide; D008472:Medazepam; D002746:Chlorpromazine
Zur antihämolytischen Wirkung einiger Benzodiazepine an mesenchlichen Erythrozyten