Use of microcapsules as timed-release parenteral dosage form: application as radiopharmaceutical imaging agent.
The development of a new type of parenteral dosage form is described. A system of microencapsulation was formulated which produced microcapsules containing a water-soluble core material. The basic microencapsulation system could be altered to produce microcapsules with varied timed-release characteristics. Tracer methodology was employed as a sensitive and versatile analytical tool for the development and evaluation of the microencapsulation system. The core material was labeled by neutron activation after microcapsule formulation, which eliminated the radiation hazard and contamination problems that could occur during formulation with a labeled core material. Both in vitro and in vivo testing showed that the release patterns of labeled core material could be altered and detected. The microcapsules developed have potential as a timed-release parenteral dosage form and as an organ-imaging radiopharmaceutical.
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D006050:Gold Radioisotopes; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008863:Microspheres; D011877:Radionuclide Imaging / Q000379:methods*; D012995:Solubility; D013997:Time Factors
D003692:Delayed-Action Preparations; D006050:Gold Radioisotopes