[Comparative evaluation of the antitoxic activity of central nervous system analeptics and their combinations in barbamyl poisoning].
Tests conducted on rats poisoned with increasingly lethal doses of sodium amytal demonstrated the antitoxic activity of an analeptic mixture to be superior to that of picrotoxin, strichnine, corasol and caffeine entering into its composition and also to the activity of bemegride. As to the degree of antitoxic activity in poisoning of mice with sodium amytal (one LD50) the CNS analeptics are arranged in the following descending oder of their action: analeptic mixture, picrotoxin, bemegride, corasol, strychnine. In poisoning with higher doses of sodium amytal (LD84) corasol, strychnine and caffeine are ineffective, the most productive being analeptic mixture and picrotoxin. Bemegride proves effective only in a single dose of 2.8 LD50 for intact animals.
D000654:Amobarbital / Q000506:poisoning* / Q000633:toxicity; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001534:Bemegride / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011041:Poisoning / Q000188:drug therapy*; D013331:Strychnine / Q000494:pharmacology
D000654:Amobarbital; D000661:Amphetamine; D001534:Bemegride; D002110:Caffeine; D000697:Central Nervous System Stimulants; D004338:Drug Combinations; D010433:Pentylenetetrazole; D010852:Picrotoxin; D013331:Strychnine
Sravnitel'naia otsenka antitoksicheskoĭ aktivnosti analeptikov tsentral' nervnoĭ systemy i ikh kombinatsii pri otravlenii barbamilom