[Effect of the crystallization conditions of tetracycline base on the properties of the powders and drug forms obtained. The dependence of the degree of dispersion of tetracycline base on the crystallization conditions].
Characteristics of the powder dispersity of tetracycline base samples prepared by directed crystallization with variation of the process conditions were determined by the sedimentation method. It was found that the speed of the solution agitation had the maximum effect on the level and nature of the dispersity. The rate of the solution temperature and pH changing during the crystallization process had also a significant effect at low agitation speed.
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D006863:Hydrogen-Ion Concentration; D010316:Particle Size; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D011208:Powders; D012996:Solutions; D013696:Temperature; D013752:Tetracycline / Q000494:pharmacology*
D010592:Pharmaceutic Aids; D011208:Powders; D012996:Solutions; D013752:Tetracycline
Vliianie uslovĭ kristallizatsii tetratsiklina osnovaniia na svoĭstva poluchaemykh poroshkov i lekarstvennykh form. Zavisimost' dispersnosti poroshkov tetratsiklina osnovaniia ot usloviĭ kristallizatsii.