Relationship between gastro-oesophageal acid reflux, basal gastro-oesophageal sphincter pressure, and gastric acid secretion.
Twelve-hour continuous pH-recording at the distal end of the oesophagus and measurement of basal gastro-oesophageal sphincter pressure with perfused catheters were carried out in 108 subjects. Fasting gastric secretion, basal secretion, and maximal acid secretion after subcutaneous injection of 6 microgram pentagastrin/kg bodyweight were determined additionally in some of the subjects. There was a significant inverse correlation between the results of continuous pH-recording and basal gastro-oesophageal sphincter pressure, which confirms the relationship between low sphincter pressure and gastro-oesophageal acid reflux. Furthermore, there was a significant direct correlation between the results of continuous pH-recording and the volume of basal secretion and the basal acid output. These findings emphasize the significance of gastric acid secretion for the results of continuous pH-recording. As reflux-preventive surgery may elicit alterations in the variables of acid secretion, the results of continuous pH-recording do not allow conclusions to be drawn with regard to the effectiveness of a surgically established gastro-oesophageal barrier.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004943:Esophagogastric Junction / Q000502:physiology*; D005215:Fasting; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005764:Gastroesophageal Reflux; D005769:Gastrointestinal Motility; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D011312:Pressure
D010418:Pentagastrin