Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam.
20 mg of medazepam were taken by mouth by 9 healthy volunteers in an acute absorption study. About a 10-fold variation was found during the first 6 hours after the drug in individual serum medazepam, diazepam, and N-desmethyldiazepam levels. In a subacute study 10 mg of medazepam t.i.d. was given to 10 institutionalized mentally subnormal adults with emotional disorders. After 14 days' treatment serum N-desmethyldiazepam levels were generally above 800 ng/ml, 7 to 8 times higher than the serum medazepam or diazepam levels measured 12 hours after the last dose. No correlation was observed between the serum concentration and efficacy of medazepam.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000097:blood*; D055598:Chemical Phenomena; D002621:Chemistry; D003975:Diazepam / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D008607:Intellectual Disability / Q000097:blood; D008297:Male; D008472:Medazepam / Q000008:administration & dosage / Q000097:blood*; D003708:Nordazepam / Q000097:blood*
D014151:Anti-Anxiety Agents; D003708:Nordazepam; D008472:Medazepam; D003975:Diazepam