Identification of the metabolites of trichlorocarbanilide in the rat.
The metabolism and excretion of 14C-labeled 3,4,4'-trichlorodiphenylurea has been studied in the rat after oral and iv administration. More than 80% of the administered radioactivity was excreted in the feces and urine over 5 days. Five isolated metabolites were characterized by mass spectrometry and by comparative thin-layer chromatography with synthesized compounds. Metabolites found include 2'-hydroxy-, 3'-hydroxy-, 6-hydroxy-, 2',6-dihydroxy- and 3',6-dihydroxy-3,4,4'-trichlorodiphenylurea.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000378:metabolism*; D001711:Biotransformation; D002224:Carbanilides / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006900:Hydroxylation; D008297:Male; D013058:Mass Spectrometry; D051381:Rats
D000891:Anti-Infective Agents, Local; D002224:Carbanilides; C009540:triclocarban