Surface activity of some psychotropic drugs.
Diazepam was found to be the most surface active substance in aqueous solutions, chlorpromazine was less active and the lowest activity was found for haloperidol. The surface activity in blood was similar. The effect of pH on the surface activity of chlorpromazine solutions was observed.
D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D011199:Potentiometry; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013500:Surface Tension; D013501:Surface-Active Agents
D011619:Psychotropic Drugs; D013501:Surface-Active Agents; D006220:Haloperidol; D003975:Diazepam; D002746:Chlorpromazine