Enhancement of murine cytomegalovirus infection during graft-vs.-host reaction.
A mouse model was used for elucidation of the role of a graft-vs-host reaction in promoting cytomegalovirus infection. F1 (DBA/2 X C3H/He) hybrid mice were infected with murine cytomegalovirus. Five weeks later, a graft-vs.-host reaction was produced in the chronically infected animals by the administration of multiple doses of DBA/2 parental splenocytes. Cytomegalovirus was recovered more often from the organs of mice undergoing graft-vs.-host reaction than from those of control animals (P less than 0.001). These results indicate that the graft-vs.-host reaction alone can enhance murine cytomegalovirus infection in a chronically infected host and may help explain the high incidence of cytomegalovirus infection after bone marrow allograft transplantation in man.
D000818:Animals; D002908:Chronic Disease; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006087:Graft vs Host Reaction; D006824:Hybridization, Genetic; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D009929:Organ Size; D012469:Salivary Glands / Q000382:microbiology; D013154:Spleen / Q000382:microbiology / Q000473:pathology