The distribution and elimination of radioactivity in the rat after administration of 14C-4-acetamidophenyl-2-acetoxybenzoate (benorylate).
Following oral administration of 4-acetamido-phenyl-2-acetoxybenzoate (carboxyl-14C) (benorylate) to rats, no gross differences were detected 7.5 h after administration with respect to the distribution of 14C in various tissues, including the upper sections of the small intestine. A high concentration of 14C was found in the lower sections of the intestine 4 h after administration. The 14C in the intestine was present as unchanged benorylate, as detected by thin-layer chromatography, suggesting that benorylate absorption was slow. Intravenous injection of 14C-benorylate to rats showed that the drug had a relatively high elimination rate from the blood with a half-life of 1.9 h. In blood benorylate must be rapidly hydrolysed enzymatically since no 14C-metabolites, other than salicylic acid, could be detected.
D000273:Adipose Tissue / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D006207:Half-Life; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D012459:Salicylates / Q000008:administration & dosage / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D002250:Carbon Radioisotopes; D012459:Salicylates