Dynamic asymmetries in liver tyrosine aminotransferase induction.
Changes in liver tyrosine aminotransferase activity were measured in mice and rats following a whole body X-irradiation in order to ascertain the dose-effect relationship. The response was either (1) linear in case of low pulses (25 rad/min); (2) parabolic, indicating the onset of a saturation process in case of medium pulses (60 rad/min), or (3) biphasic, suggesting the cooperation of at least two regulatory mechanisms following longtime exposure to strong stimuli (100 rad/min).
D000315:Adrenalectomy; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004790:Enzyme Induction / Q000528:radiation effects; D006854:Hydrocortisone / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D011830:Radiation Effects; D051381:Rats; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000096:biosynthesis*; D014965:X-Rays
D014444:Tyrosine Transaminase; D006854:Hydrocortisone