Diminished virucidal activity of kethoxal against vesicular stomatitis virus pretreated with guanidinating reagent and proteases.
The reactivity of vesicular stomatitis virus (VSV) with kethoxal can be appreciably altered by treatment with 1-guanyl-3, 5-dimethyl pyrazole nitrate (GDMP) and proteolytic enzymes. Pretreatment of purified VSV with GDMP or proteolytic enzymes markedly reduced the effectiveness of kethoxal as a virucide. The rate of neutralizability of GDMP- and trypsin-treated viruses by specific antiserum differed from that of controls.
D000447:Aldehydes / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002074:Butanones / Q000494:pharmacology*; D002460:Cell Line; D006146:Guanidines / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D010447:Peptide Hydrolases / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D014357:Trypsin / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development
D000447:Aldehydes; D000998:Antiviral Agents; D002074:Butanones; D006146:Guanidines; D007202:Indicators and Reagents; D011720:Pyrazoles; D010447:Peptide Hydrolases; D014357:Trypsin