On the regulatory properties of a halophilic malic enzyme from Halobacterium cutirubrum.
The NADP-linked malic enzyme from Halobacterium cutirubrum is strongly inhibited by acetyl-CoA and NADH, and rather weakly inhibited by oxaloacetate and glyoxylate, in the presence of very high KCl concentrations (3 M), considered physiological for the extremely halophilic bacteria.
D000105:Acetyl Coenzyme A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006038:Glyoxylates / Q000494:pharmacology; D006217:Halobacterium / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D008291:Malate Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism*; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000378:metabolism; D010071:Oxaloacetates / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology
D006038:Glyoxylates; D010071:Oxaloacetates; D009243:NAD; D009249:NADP; D011189:Potassium Chloride; D000105:Acetyl Coenzyme A; D008291:Malate Dehydrogenase