[Effect of tropaphene and fentolamin on the spasmogenic effects of adrenaline, noradrenaline, serotonin and other biologically active substances].
Tests conducted in vitro and in vivo demonstrated that tropaphen, tropine ether of alpha-phenyl-beta-(p-acetoxyphenyl)-propionic acid, an original alpha-adrenoblocking agent, display a marked antiserotonin activity exceeding that of phentolamine. Moreover, tropaphen is more active that phenolamine by its inhibiting influence on the spasmogenous effects of histamine, angiotensin, bradykinine and prostaglandin E2. In doses of 0.1 and 0.25 mg/kg both drugs had no effect on changes of the arterial pressure in anesthetized rats, caused by the above mentioned biologically active substances.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013035:Spasm / Q000139:chemically induced*; D014326:Tropanes / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D010666:Phenylpropionates; D011459:Prostaglandins E, Synthetic; D014326:Tropanes; D000804:Angiotensin II; D012701:Serotonin; C009599:tropodifene; D006632:Histamine; D001920:Bradykinin; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine
Vliianie tropafena i fentolamina na spazmogennye éffekty adrenalina, noradrenalina, serotonina i drugikh biologicheski aktivnykh veshchestv.