Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+.
The addition of Sr2+ or Ba2+ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr2+ and Ba2+ increase release are not the same. Each ion appears to act selectively on a different process involved in transmitter release.
D000818:Animals; D001001:Anura; D001464:Barium / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004558:Electric Stimulation; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011894:Rana pipiens; D013324:Strontium / Q000494:pharmacology*; D013997:Time Factors
D018377:Neurotransmitter Agents; D001464:Barium; D008274:Magnesium; D002118:Calcium; D013324:Strontium