Scleroderma, Sjögren-like syndrome, and chronic graft-versus-host disease.
A patient with acute myelogenous leukemia treated with an allogeneic bone marrow transplant developed acute graft-versus-host disease manifested by severe diarrhea, hepatitis, and a cutaneous eruption. As the graft-versus-host disease progressed to the chronic phase, the patient developed marked cutaneous sclerosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both graft-versus-host disease and scleroderma. Results of Schirmer's tests, corneal fluorescent studies, parotid flow-rate testing, and a lip biopsy were consistent with Sjögren's syndrome. Possibly, activated lymphocytes may have a role in the pathogenesis of graft-versus-host disease, scleroderma, and Sjögren's syndrome.
D000328:Adult; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D006087:Graft vs Host Reaction; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D012594:Scleroderma, Localized / Q000150:complications* / Q000209:etiology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000209:etiology; D014184:Transplantation, Homologous / Q000009:adverse effects