Relationships between opiate receptor binding and analgetic properties of prodine-type compounds.
The receptor binding affinities of some diastereoisomeric prodine analgoues have been compared with their analgetic activities determined by the hot-plate test in mice. The close correlation found between these potencies indicates that the relative analgetic activities of the alpha/beta isomers are determined primarily by the appropriate association to the receptor sites.
D000522:Alphaprodine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000701:Analgesics, Opioid; D000818:Animals; D001921:Brain / Q000378:metabolism; D066298:In Vitro Techniques; D007536:Isomerism; D008968:Molecular Conformation; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000701:Analgesics, Opioid; D011957:Receptors, Opioid; D000522:Alphaprodine