[The second electromyographic study of surgical curarization with AH.8165, a new pachycurare derivative of azobis-arylimidazo(1-2a) pyridinium].
This second electromyographic study of AH-8165, a product derived from azobis-arymilidazo-(1-2a) pyridinium, carried out with a special apparatus which both stimulates and records, specifies the characteristics of the neuro-muscular block induced by this new non-depolarizing type curarizing substance while taking into account the usual factors of the curarimimetic variability of action. After an initial dose of 1 mg per kg of bodyweight, we notice particularly: -the lapse of time required for a complete block (90 s), its intensity and duration (normally total during at least one hour) -the morphology of the electromyogram during the curarization and the decurarization either spontaneous or induced by Neostigmin with in particular -the muscular fatigability after repeated stimulation following curarization and chiefly during decurarization, chronological data und electro-myographic aspects which are found as well after a reinjection of AH-8165 equivalent to the half of the previous one.
D000200:Action Potentials; D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D004576:Electromyography; D005221:Fatigue; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology; D009407:Nerve Block; D003473:Neuromuscular Nondepolarizing Agents; D011726:Pyridinium Compounds / Q000494:pharmacology*
D003473:Neuromuscular Nondepolarizing Agents; D011726:Pyridinium Compounds; D009388:Neostigmine
Seconde étude électromyographique de la curarisation chirurgicale par ah.8165, nouveau pachycurare dérivé de l'azobis-arylimidazo-(1-2a) pyridinium