Cardiovascular actions of bromocriptine.
Bromocriptine lowers blood pressure in animals and in man. Results obtained in experiments performed in the dog and cat suggest three possible mechanisms of action: a) relaxation of vascular smooth muscle, principally in splanchnic and renal vessels, (b) inhibition of transmitter release from noradrenergic nerve endings, (c) central inhibition of sympathetic nerve activity. The effect of bromocriptine at each putative site of action can be explained in terms of dopamine receptor stimulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D001971:Bromocriptine