[Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine].
The effect of norepinephine, an adrenomietic drug, and of pyrroxane, its antagonist, on diethylnitrosoamine (DENA) hepatocarcinogenesis was studied in albino rats. Norepinephrine was found to stimulate carcinogenesis, whereas pyrroxane--to inhibit this process; the latter drug decreased the incidence of multicentric tumours of the liver. In vitro experiments on the isolated rat atria showed low DENA concentrations (1x10(-6) to 1x10(-8) M) to sensitize the atrium adrenoreceptors to the endogenous and exogenous norepinephrine. A new hypothesis on the adrenergic component in the DENA carcinogenic effect caused by the endogenous norepinephrine is presented.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents; D002273:Carcinogens; D004052:Diethylnitrosamine / Q000037:antagonists & inhibitors; D004146:Dioxanes / Q000627:therapeutic use*; D004147:Dioxins / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D009374:Neoplasms, Experimental; D009602:Nitrosamines; D009638:Norepinephrine / Q000633:toxicity*; D011759:Pyrrolidines / Q000627:therapeutic use; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000970:Antineoplastic Agents; D002273:Carcinogens; D004146:Dioxanes; D004147:Dioxins; D009602:Nitrosamines; D011759:Pyrrolidines; D004052:Diethylnitrosamine; C009143:proroxan; D009638:Norepinephrine
Adrenergischeskiĭ komponent v gepatotropnom kantserogennom éffekte diétilnitrozamina