Active control of intracellular pH.
When the interior of a squid giant axon is loaded with acid, the cell responds by extruding that acid in an energy-requiring process. Our results indicate that this acid extrusion is accomplished by exchanging external HCO3- for internal Cl- at the expense of ATP.
D000136:Acid-Base Equilibrium; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000378:metabolism*; D001693:Biological Transport, Active; D003486:Cyanides / Q000494:pharmacology; D049832:Decapodiformes; D004140:Dinitrophenols / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007424:Intracellular Fluid / Q000502:physiology
D003486:Cyanides; D004140:Dinitrophenols; D000255:Adenosine Triphosphate