[The effect of prednisolone on the development of the galactosamine hepatitis of young and old rats (author's transl)].
The present work reports on kinetic and morphological studies of one hundred female albino rats after the administration of galactosamine and galactosamine and prednisolone. The results demonstrate a significant higher increase of the serum transaminasess got and gpt in the older than in the younger rats as well as a protecting effect of prenisolone against galactosamine produced disturbances. In the thirty months old rats the protection against morphological and biochemical disturbances was only demonstrable for the first twelve hours after the administration of galactosamine.
D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005688:Galactosamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D006801:Humans; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats
D005688:Galactosamine; D011239:Prednisolone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Der einfluss von Prednisolon auf die Entwicklung der Galaktosamin-Hepatitis junger und alter Ratten