Effect of altered lymphocyte function on immunologic disorders in NZB/NZW mice.
NZB/NZW F1 female mice were treated with the immunosuppresive enzyme L-asparaginar antibodies, diminished deposition of gamma-globulins in kidneys, significantly delayed the onset of proteinuria, and reduced deaths from nephritis. These effects were associated with reduction of cellular IgM antibody synthesis to both T-dependent and T-independent antigens, but the graft-versus-host reaction was not affected. After several weeks of therapy, antibodies against Asnase appeared in the circulation, the effect on antibody synthesis was lost, ANA and anti-DNA appeared, followed by proteinuria and deaths from nephritis. Therefore Asnase proved to be an effective therapy in NZB/NZW mice, but its usefulness was limited by the appearance of inactivating antibodies.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001215:Asparaginase / Q000276:immunology / Q000494:pharmacology; D004247:DNA / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006087:Graft vs Host Reaction / Q000187:drug effects; D006462:Hemolytic Plaque Technique; D007105:Immune Complex Diseases / Q000276:immunology*; D007075:Immunoglobulin M / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D004247:DNA; D001215:Asparaginase