[Effect of carbidine on the content and storage of adrenergic neurotransmitter in the synaptic vesicles].
The influence of carbidine, an original psychotropic drug, on the adrenergic neurotransmitter content and storage in the sympathetic nerves was studied with the use of cytochemical electron microscopy. The influence of carbidine on the uptake of the exogenous noradrenaline (NA) in the synaptic vesicles was also studied. Carbidine was found to be capable to decreasing the NA storage in the synaptic vesicles and failed to block the accumulation of the exogenous NA in the synaptic vesicles.
D000588:Amines / Q000378:metabolism; D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013572:Synaptic Vesicles / Q000187:drug effects* / Q000378:metabolism; D014439:Tyramine / Q000494:pharmacology; D014649:Vas Deferens / Q000294:innervation
D000588:Amines; D002243:Carbolines; D007211:Indoles; D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic; D009638:Norepinephrine; D014439:Tyramine
Vliianie karbidina na soderzhanie i deponirovanie adrenergicheskogo neĭroperedatchika v sinapticheskikh puzyr'kakh