A general mechanism for microsomal activation of quinone anticancer agents to free radicals.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D001665:Binding Sites; D001711:Biotransformation; D004579:Electron Transport; D005609:Free Radicals; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000378:metabolism; D008297:Male; D051379:Mice; D008861:Microsomes / Q000378:metabolism*; D008956:Models, Chemical; D009249:NADP / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000378:metabolism; D010101:Oxygen Consumption; D011809:Quinones / Q000378:metabolism; D051381:Rats
D000903:Antibiotics, Antineoplastic; D005609:Free Radicals; D011809:Quinones; D009249:NADP