Methodical aspects of the experimental chemotherapy of viral infections.
An analysis of the methods of testing the antiviral activity in vitro (in cell cultures) and in vivo (in experimental virus infections) is presented. The necessity of applying two-stage screening in vitro is emphasized. The chemotherapeutic viral models is in vitro testing as well as the principles of modelling of experimental viral infections are examined. Criteria for stage-by-stage assessment of the antiviral activity of the substances tested are formulated.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D046508:Culture Techniques; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D014777:Virus Diseases / Q000188:drug therapy*; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents