Uropharmacology: VII. Ganglionic stimulating and blocking agents.
A classification of the various ganglionic stimulants and blockers is presented, and their pharmacologic effects on the urinary bladder and urethra are discussed. Ganglionic stimulating drugs are of considerable interest in investigational work but are not presently used therapeutically. Ganglionic blockers include hexamethonium, tetraethylammonium, mecamylamine emepronium, pentolinium, chlorisondamine, and pemipidine. Of the numerous ganglionic blocking drugs that have appeared on the therapeutic scene, only mecamylamine, pentolinium, and trimethaphan are currently official.
D000818:Animals; D002714:Chlorisondamine / Q000494:pharmacology; D004629:Emepronium / Q000494:pharmacology; D005730:Ganglionic Blockers / Q000494:pharmacology*; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D010425:Pentolinium Tartrate / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D014521:Urethra / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*
D005730:Ganglionic Blockers; D005731:Ganglionic Stimulants; D006584:Hexamethonium Compounds; D013757:Tetraethylammonium Compounds; D004629:Emepronium; D008464:Mecamylamine; D010425:Pentolinium Tartrate; D002714:Chlorisondamine