Vascular beta-adrenoceptor stimulating properties of phenylephrine.
In pithed rats pretreated with propranolol changes occurred in the slopes of dose--pressor response curves to i.v. phenylephrine and noradrenaline but not to LD 3098, a pure alpha-adrenoceptor stimulant. In dogs, cats, and spontaneously hypertensive rats pretreated with an alpha-adrenoceptor blocker, i.v. phenylephrine induced vasodilatory responses which were antagonised by propranolol. These results indicate that phenylephrine, in addition to its known beta1-agonistic properties, stimulates the vascular beta2-adrenoceptors.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003521:Cyclopropanes / Q000494:pharmacology; D004347:Drug Interactions; D007093:Imidazoles / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D014666:Vasomotor System / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D003521:Cyclopropanes; D007093:Imidazoles; D010643:Phenoxybenzamine; D010656:Phenylephrine; D011433:Propranolol; D007545:Isoproterenol; D000420:Albuterol; C014282:cirazoline; D009638:Norepinephrine; D011224:Prazosin