[Cyproheptadine as an inhibitor of the effects of bradykinin].
A study was made of the influence of ciproheptadin, serotonin and histamine inhibitor, on the effects of exo- and endogenous bradykinin. Ciproheptadin inhibited the effect of bradykinin on a section of a guinea pig intestine in vitro, eliminated the hypotensive effect of bradykinin in rats in vivo, and also blocked the constriction of the vessels of the ear in rabbit and a fall of the blood kininogen level caused by the administration of pyrogenal.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D003533:Cyproheptadine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000098:blood supply; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D007704:Kininogens / Q000097:blood; D011749:Pyrogens / Q000037:antagonists & inhibitors; D011817:Rabbits; D051381:Rats; D012702:Serotonin Antagonists; D014666:Vasomotor System / Q000187:drug effects
D006634:Histamine H1 Antagonists; D007704:Kininogens; D011749:Pyrogens; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D001920:Bradykinin
Tsiprogeptadin kak ingibitor éffektov bradikinina