[Methylation of liver cell chromatin proteins at different stages of post-natal development of albino rats].
Methylation of acid proteins and various histone fractions of liver cell chromatin was studied. The intensity of methylation of acid proteins of animals, differing in age, was shown to be 8--16 times higher than that for histone methylation, despite the fact that the rates of 2-14C-methionine incorporation into these two groups of proteins were practically the same. The intensity of methylation of acid proteins and total histones significantly increased during the post-natal development of the animals. Histone methylation largely occurred at the expense of the arginine-rich H3 fraction and the H2 fraction with a moderate level of arginine and lysine. Lysine-rich histone fractions were not subjected to methylation. It is assumed that chromatin proteins methylation regulates conformational properties of the complex and matrix properties of the genome.
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D005838:Genotype; D006128:Growth; D006657:Histones / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000378:metabolism*; D008745:Methylation; D011487:Protein Conformation; D051381:Rats; D013329:Structure-Activity Relationship
D002843:Chromatin; D006657:Histones
Metilirovanie belkov khromatin kletok pecheni na raznykh etapakh Postnatal'nogo Razvitiia belykh krys