[Comparative study of the effect of haloperidol and maptil on the karyotype and immunoproliferative response of lymphocytes].
The author examined the action of haloperidol and magetyl on the mitotic activity, blast transformation and karyotype of the lymphocytic cultures, obtained from the peripheral blood in vitro. The experiments were carried out on flymphycytes, obtained from ten healthy individuals. Nontreated cultures, obtained from the same cultures, were used as controls. The following concentrations were used: haloperidol--0.1 mkg/ml, 10 mkg/ml and 10.0 mkg/ml; mageptyl--2.0 mkg/ml, 10,0 mkg/ml and 50 mkg/ml. There was a significant inhibition of the mitotic and blast transformation index after using concentrations of 10.0 mkg/ml both of haloperidol and magentyl. Concentration of 50.0 mkg/ml was toxic for the lymphocytes, obtaine from all donors. Furthermore the two preparations did not induce genomic mutations. Polyploidia, established in the treated cultures, varied slightly from that of the nontreated cultures. There was a weak mutagenic activity of the two preparations at chromosomal level in a concentration of 10.0 mkg/ml.
D002478:Cells, Cultured; D005260:Female; D006220:Haloperidol / Q000633:toxicity*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008940:Mitotic Index; D009153:Mutagens; D010640:Phenothiazines / Q000633:toxicity*; D014149:Tranquilizing Agents / Q000633:toxicity
D009153:Mutagens; D010640:Phenothiazines; D014149:Tranquilizing Agents; D006220:Haloperidol
Sravnitelno prouchvane na deĭstvieto na khaloperidola i mazheptila vurkhu kariotipa i imunoproliferativniia otgovor na limfotsita