[Graft-versus-host reaction following granulocyte transfusion from a normal donor (author's transl)].
Graft-versus-Host disease following the transfusion of leukocytes from normal donor occured during remission-reinduction therapy in a 5 years old girl with acute lymphocytic leukemia. The clinical picture consisting of rash, diarrhea and somnolence was congruent with the diagnosis. Graft-versus-Host disease was confirmed by histology of skin biopsy and exclusion of other causes. The child survived the disease. We recommend the irradiation of leukocyte concentrates before transfusion.
D001706:Biopsy; D002675:Child, Preschool; D005260:Female; D006087:Graft vs Host Reaction; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology / Q000628:therapy; D017708:Leukocyte Transfusion; D012867:Skin / Q000473:pathology; D065227:Transfusion Reaction
Graft-versus-Host-Reaktion nach Granulozytentransfusion von einem Normalspender.