Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics.
Using a food-reinforced two-lever operant procedure, rats (n=6) were trained to discriminate fentanyl (1.25 mg/kg, p.o., t-60') from solvent (1 ml/100 g B.W., p.o., t-60'). The administration of another narcotic analgesic (pethidine) produced a dose-related generalization with the standard fentanyl treatment; six non-narcotic analygesics (suprofen, acetylsalicylic acid, indomethacin, phenacetin, phenylbutazone, tolmetin) were found not to do so. It is concluded that the ability of drugs to produce analgesia is not a sufficient condition for the drugs to produce the narcotic cue as well.
D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects; D005283:Fentanyl / Q000494:pharmacology; D008614:Meperidine / Q000494:pharmacology; D010615:Phenacetin / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D051381:Rats; D014046:Tolmetin / Q000494:pharmacology
D000700:Analgesics; D000701:Analgesics, Opioid; D011448:Prostaglandin Antagonists; D008614:Meperidine; D014046:Tolmetin; D010615:Phenacetin; D010653:Phenylbutazone; D005283:Fentanyl