Perinephritis hypertension in monkeys. I. An increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis.
The renal parenchyma of 5 crub-eating monkeys (Macaca irus) was wrapped by cellophane, and plasma renin activity, blood pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. The results demonstrated that increases of systolic arterial pressure, plasma renin activity, and permeability of the retinal vessels were found in 4 operated monkeys. There was no such abnormal finding in the unoperated control monkeys. Generally there was a rough parallelism among levels of plasma renin activity and systolic blood pressure, an increase of permeability of retinal vessels and fibrinoid angionecrosis and/or necrotizing angitis similar to polyarteritis nodosa.
D000818:Animals; D001794:Blood Pressure; D001808:Blood Vessels / Q000473:pathology; D002199:Capillary Permeability; D004195:Disease Models, Animal; D005260:Female; D005451:Fluorescein Angiography; D000882:Haplorhini; D006977:Hypertension, Renal / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology; D008251:Macaca; D008297:Male; D009392:Nephrectomy; D010501:Perinephritis / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D010488:Polyarteritis Nodosa / Q000473:pathology; D012083:Renin / Q000097:blood*; D012171:Retinal Vessels / Q000503:physiopathology*
D012083:Renin