[Changes of circulation, blood gases, acid-base-and metabolism during neurolept-analgesia with and without beta-receptor blockers in electro coagulation of Gasser's ganglion (author's transl)].
The cardiovascular, blood gas, acid-base and metabolic changes occurring during operative stress were studied in 10 elderly, metabolically healthy patients, suffering from idiopathic trigeminal neuralgia, who underwent electrocoagulation of the gasserian ganglion under neuroleptanalgesia. In a group of 12 patients undergoing the same operative procedure and anesthesthetic management, we investigated the effects of administration of a beta blocking agent on these parameters. Intraoperative rises of blood pressure and tachycardia were prevented by intravenous administration of 0.4 mg Pindolol (Visken), whereas increases in the blood glucose levels at the end of the operation were the same. The increase of glycerol, free fatty acids and ketone bodies was markedly reduced after pretreatment with the beta blocker compared with the controlgroup. In the patients without beta blocker treatment pH and standard bicarbonate at the end of the operation were lower as the result of the stimulation of ketogenesis.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000368:Aged; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004564:Electrocoagulation; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007657:Ketone Bodies / Q000097:blood; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D008875:Middle Aged; D009458:Neuroleptanalgesia; D010869:Pindolol / Q000494:pharmacology*; D013610:Tachycardia / Q000139:chemically induced; D014276:Trigeminal Nerve / Q000601:surgery*; D014277:Trigeminal Neuralgia / Q000601:surgery
D001639:Bicarbonates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D010869:Pindolol; D005990:Glycerol
Kreislaufverhalten, Blutgase, Säure-Basen- und Stoffwechselveränderungen unter Neuroleptanalgesie mit und ohne Betarezeptorenblocker bei der Elektrokoagulation des Ganglion Gasseri.