Microbial acetylation of M factor of virginiamycin.
The M component of virginiamycin was found to be modified by whole cells or cell-free enzyme preparations of a Staphylococcus aureus strain. It was shown that this reaction proceeds by enzymatic acetylation of the secondary alcoholic function of the molecule, followed by a rapid chemical degradation of the O-acetylated product.
D000107:Acetylation; D001711:Biotransformation; D003470:Culture Media / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008248:Lysostaphin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*; D014769:Virginiamycin / Q000378:metabolism*
D003470:Culture Media; D014769:Virginiamycin; D008248:Lysostaphin