Treatment of cryptorchidism with a potent analog of gonadotropin-releasing hormone.
Pernasal therapy of cryptorchidism with D-Leu6-des-Gly10-gonadotropin-releasing hormone ethylamide (D-Leu6-des-Gly10-GnRH-EA), a potent, long-acting GnRH analog, was attempted. Eleven prepubertal cryptorchid boys received between 25 microgram once daily and 25 to 50 microgram twice daily for 5 to 12 weeks. Complete testicular descent was achieved in 4 of the 11 boys. GnRH tests (1.5 microgram/kg intravenously), conducted in six boys before treatment, after 4 weeks of treatment, and in 2 boys 3 months after treatment, did not reveal changes in gonadotropin secretion indicative of precocious puberty or of decreased hypophyseal sensitivity to GnRH. Antibodies to the GnRH analog or to GnRH could not be detected.
D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000628:therapy*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones / Q000276:immunology / Q000627:therapeutic use*; D013997:Time Factors
D006062:Gonadotropins; D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone