title: Production of beta-(4-hydroxyphenyl)ethanol and beta-(4-hydroxyphenyl)lactic acid by Candida species.
abstract: Two crystalline compounds were isolated from the culture filtrates of Candida species grown in synthetic medium supplemented with L-tyrosine as the sole source of nitrogen. These compounds were characterized as beta-(4-hydroxyphenyl)ethanol (HOPEA) and beta-(4-hydroxyphenyl)lactic acid (HOPLA). The production of these compounds in five species (both pathogenic and non-pathogenic) was compared and marked differences were revealed. Experiments using L-[14C]tyrosine indicated that both HOPEA and HOPLA are synthesized from L-tyrosine.
mesh_terms: D002175:Candida / Q000032:analysis / Q000378:metabolism*; D000431:Ethanol / Q000031:analogs & derivatives*; D007773:Lactates / Q000096:biosynthesis*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000096:biosynthesis; D013045:Species Specificity; D014443:Tyrosine / Q000378:metabolism
chemical_list: D007773:Lactates; C011867:4-hydroxyphenylethanol; D000431:Ethanol; D014443:Tyrosine; D010626:Phenylethyl Alcohol