[Patho-physiological aspects in csf proteins (author's transl)].
Electrophoresis and immunoelectrophoresis of cerebrospinal fluid of 201 patients with inflammatory CNS diseases revealed that over a total protein value from 0 to greater than 1, 2 g/1 there was merely a decrease in pre-albumins and a difference in the gamma-globulins as a pointer to immune reactions. Comparison with the absolute values indicated an increase of all fractions in inflammatory and non inflammatory diseases caused by impairment of the blood-CSF barrier. Again there was evidence of immune reaction in the gamma-globulin range. Impairment in the blood-CSF barrier was demonstrated by an increased concentration of IgG, IgA and IgM. An immune reaction was revealed by higher IgG values.
D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins; D004586:Electrophoresis; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D011228:Prealbumin / Q000134:cerebrospinal fluid; D005719:gamma-Globulins / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D011228:Prealbumin; D005719:gamma-Globulins
Zur Pathophysiologie der Liquorproteine