Oxime derivatives of erythromycin: inhibitors of Rous sarcoma virus reverse transcriptase activity and focus formation.
9-O-methyloximd erythromycin A and its analogue inhibited reverse transcriptase and blocked focus formation of Rous sarcoma virus. These chemicals inhibited neither DNA-dependent DNA polymerase nor DNA-dependent RNA polymerase from bacterial sources. However, they inhibited reverse transcriptase with an apparently differnt mechanism than that by rifamycin ABDP.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002642:Chick Embryo; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D005347:Fibroblasts; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins; D004917:Erythromycin