Release of motilin after duodenal acidification.
The physiological stimulus leading to motilin release in man has not yet been determined. Six healthy volunteers had 3-minute intraduodenal infusions of acid, alkali, or saline solutions. After infusing acid, plasma-motilin rose by 90% at 4 min and was still significantly raised at 45 min, whereas there was an insignificant fall in plasma-motilin after alkali and no change after saline solution. Release of motilin after duodenal acidification may be an important factor in inhibiting gastric emptying.
D000293:Adolescent; D000328:Adult; D002021:Buffers; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D005769:Gastrointestinal Motility; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007413:Intestinal Mucosa / Q000378:metabolism*; D007419:Intestinal Secretions / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008297:Male; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology
D002021:Buffers; D005768:Gastrointestinal Hormones; D012965:Sodium Chloride; D006851:Hydrochloric Acid