Bartter's syndrome. Differentiation into two clinical groups.
We were able to separate Bartter's syndrome patients into two groups: Group 1 patients are seen at a young age, with hyponatremia and episodes of extracellular volume contraction. Group 2 patients are older and most have tetany; plasma sodium values and renal sodium balances are normal. Plasma potassium values are lower and plasma renin activity and plasma magnesium levels are higher in group 1 than in group 2. It may be that all patients with Bartter's syndrome manifest the features of both groups, group 1 patients with time developing into group 2 patients. These observations have important implications in the treatment of patients with Bartter's syndrome.
D000450:Aldosterone / Q000652:urine; D001477:Bartter Syndrome / Q000175:diagnosis* / Q000178:diet therapy / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000097:blood; D004032:Diet; D005110:Extracellular Space; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006929:Hyperaldosteronism / Q000175:diagnosis*; D007010:Hyponatremia; D007223:Infant; D008274:Magnesium / Q000097:blood / Q000627:therapeutic use; D008297:Male; D011188:Potassium / Q000097:blood / Q000627:therapeutic use; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood / Q000652:urine; D012965:Sodium Chloride / Q000627:therapeutic use; D013746:Tetany / Q000209:etiology
D002712:Chlorides; D012965:Sodium Chloride; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D008274:Magnesium; D011188:Potassium; D002118:Calcium