Behavioral toxicity. Neuroleptic-induced paradoxical behavioral toxicity in young borderline schizoprenics.
9 young borderline schizophrenics who developed an acute paradoxical behavioral toxicity as a reaction to the initiation of antipsychotic medication are described. The dynamics, the psychological issues as well as some possible psychopharmacological interactions are discussed. The risk of behavioral toxicity should not be overlooked or underestimated and the occurrence of this reaction must be carefully differentiated from other drug-induced reactions.
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002746:Chlorpromazine / Q000009:adverse effects; D005260:Female; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D010551:Personality; D012569:Schizotypal Personality Disorder / Q000188:drug therapy*; D013881:Thioridazine / Q000009:adverse effects
D014150:Antipsychotic Agents; D006220:Haloperidol; D013881:Thioridazine; D002746:Chlorpromazine