The effect of Trimepranol on thrombocyte function and histamin release in the rat.
Trimepranol a beta adrenergic blocking drug released serotonin from rat isolated and plasma-rich thrombocytes in vitro. The release was time- and dose-dependent. With the same concentrations this drug inhibited the histamine release from isolated rat mast cells. Aggregation of isolated or plasma-rich thrombocytes induced by ADP was inhibited by Trimepranol. The inhibition was dose, time dependent and reversed by calcium ions.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000097:blood
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D012701:Serotonin