The effects of repeated doses of temazepam taken in conjunction with alcohol on aspects of psychomotor performance the morning following night time medication.
A study to compare the morning-after effects of three dose levels of temazepam (Euhypnos capsules) given with alcohol, was carried out in 18 healthy volunteers. Matched placebos were given for two days before and four days after the four nights on active drug and a standard dose of alcohol was given on all ten nights of the study. Objective measurements made on the mornings after days 2, 4, 6 and 10 were critical flicker fusion threshold (CFF), choice reaction time (CRT) and digit symbol substitution tasks (DSST). The administration of 10 or 20 mg temazepam with alcohol produced no significant change inany of these measurements. 30 mg produced no change in DSST and although there was some impairment of CRT at this dose, it was not statistically significant. The combination of 30 mg temazepam and alcohol significantly depressed CFF following four nights on these drugs.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D000431:Ethanol