title: A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection.
abstract: Cell transfer experiments using mice with recombinant H-2 haplotypes were used to map the H-2 regions which must be shared by ectromelia-immune T-cell donors and virus-infected recipients for transfer of virus clearance mechanisms in the spleen. K- or D-region genes were necessary and sufficient; I-region genes  were not involved. The remainder of the mouse genome could be varied widely without impairing the efficacy of T-cell antiviral function, provided either a K or a D region was shared in the donor-receipient combination. A mutation in a single genetic element of the K region of the H-2 complex abolished the antiviral effect of immune T-cell transfer in a donor-recipient combination which shared the K end.
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D002874:Chromosome Mapping; D004481:Ectromelia virus / Q000276:immunology*; D004482:Ectromelia, Infectious / Q000276:immunology*; D000939:Epitopes; D005796:Genes; D006680:HLA Antigens; D006238:Haploidy; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D051379:Mice; D009154:Mutation; D011213:Poxviridae Infections / Q000276:immunology*; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens