Chlorpromazine-induced histamine release from guinea-pig skin in vitro--a photosensitive reaction.
Chlorpromazine releases histamine from chopped guinea-pig skin maintained in vitro at 37 degrees C. This effect was markedly potentiated by radiant energy. This potentiation increased with increasing exposure to radiant energy. The possible clinical applications of these findings are discussed.
D000818:Animals; D002746:Chlorpromazine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000276:immunology; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012867:Skin / Q000276:immunology
D002746:Chlorpromazine