title: The metabolites of procaterol HCl in urine and faeces of dog and man.
abstract: 1. The metabolites of procaterol HCl in dog urine and faeces and in human urine were qualitatively analysed by an improved g.l.c.-mass spectrometric method. 2. Trimethylsilylated derivatives of procaterol metabolites were identified by mass fragmentography as procaterol glucuronide, 5-(2-amino-1-hydroxybutyl)-8-hydroxycarbostyril (desisopropylprocaterol), 5-formyl-8-hydroxycarbostyril, 8-hydroxycarbostyril and unchanged procaterol. 3. The metabolic pattern of procaterol HCl was species-independent in rats, dogs and man.
mesh_terms: D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D000605:Amino Alcohols / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005243:Feces / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D005965:Glucuronates / Q000652:urine; D006801:Humans; D006912:Hydroxyquinolines / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D007275:Injections, Intravenous; D008297:Male
chemical_list: D000318:Adrenergic beta-Agonists; D000605:Amino Alcohols; D005965:Glucuronates; D006912:Hydroxyquinolines