title: Stereoselectivity of some oxotremorine antagonists containing two chiral centres.
abstract: The stereoisomers of some analogues of oxotremorine containing two chiral centres, one in the 1-position of the butynyl chas are oxotremorine antagonists. They show a marked stereoselectivity, which depends mainly on the configuration of the chiral centre in the butynyl chain and to a lesser extent on the configuration of that in the pyrrolidine ring.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D009184:Mydriatics; D010095:Oxotremorine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D014202:Tremor / Q000139:chemically induced
chemical_list: D009184:Mydriatics; D010095:Oxotremorine; D001285:Atropine