Variants of N-tropic leukemia virus derived from BALB/c mice.
Clonal lines derived from cultures of NIH/3T3 cells infected with N-tropic leukemia virus from BALB/c mice differ in the amount and type of N-tropic virus they produce. Three biologically distinguishable N-tropic viruses were found: the large XC plaque-forming virus of hartley et al. (1969) (LP-N), A SMALL XC plaque-forming virus (sp-n), and a non-plaque-forming virus (NP-N). SP-N and NP-N are less infectious than LP-N. Upon prolonged passage in NIH/3T3 cells NP-N gives rise to highly infectious LP-N.
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D014644:Genetic Variation; D009052:Leukemia Virus, Murine / Q000201:enzymology / Q000254:growth & development* / Q000472:pathogenicity; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013045:Species Specificity
D012194:RNA-Directed DNA Polymerase