Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland.
Incorporation of D-3-hydroxy[3-14C]butyrate into lipid in vivo suggests that lactating mammary gland is a major site of ketone-body utilization. The incorporation decreases in short-term insulin deficiency (2h) and on starvation (24h), but increases again on refeeding (2h). The activity of cytosolic acetoacetyl-CoA synthetase parallels the changes in nutritional state, but is not affected by short-term insulin deficiency.
D000101:Acetyl-CoA C-Acetyltransferase / Q000378:metabolism; D000818:Animals; D005260:Female; D006885:Hydroxybutyrates / Q000378:metabolism*; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
D006885:Hydroxybutyrates; D008055:Lipids; D000101:Acetyl-CoA C-Acetyltransferase