Comparative analysis of interferon and antiviral protein messenger RNAs.
A comparative analysis of interferon and antiviral protein messenger RNAs was carried out. Differences in their biological activities and sedimentation coefficients were found. In RNA preparations from superinduced cells (cells treated with poly(I).poly(C) and antimetabolites) and from cells treated with interferon, messenger RNAs possesing interferon and antiviral activities were detected. The results suggest the existence of two types of mRNA (for interferon and antiviral protein, respectively) and support the hypothetic model of interferon action via an antiviral protein.
D000818:Animals; D000998:Antiviral Agents / Q000096:biosynthesis*; D002460:Cell Line; D004666:Encephalitis Virus, Venezuelan Equine / Q000254:growth & development*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D011070:Poly I-C / Q000494:pharmacology; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000032:analysis* / Q000378:metabolism; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development*
D000998:Antiviral Agents; D012333:RNA, Messenger; D007372:Interferons; D011070:Poly I-C