Stimulated DNA synthesis in livers and kidneys induced to proliferate associated with unchanged thymidine and thymidylate kinase activities.
Enhanced mitotic activity and stimulated DNA synthesis associated with unchanged activity of thymidine and thymidylate kinases were observed in mouse kidneys induced to proliferate by intracardiac injection of lead acetate, and in rat livers following repeated administration of 5-azacytidine. On the other hand, the enhanced thymidine kinase activity evoked by L-tryptophan given by intubation at later stages of liver regeneration was paralleled by the enhanced incorporation of thymidine into DNA only to a very small degree.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D010770:Phosphotransferases / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism*; D013937:Thymidine Kinase / Q000378:metabolism*
D010770:Phosphotransferases; D013937:Thymidine Kinase; D001374:Azacitidine; D013936:Thymidine