title: IgA deficiency and severe post-vagotomy diarrhoea.
abstract: Between January, 1969, and December, 1973, 2058 truncal vagotomies were performed in the Merseyside Regional Health Authority area. 14 of these patients subsequently developed severe post-vagotomy diarrhoea and were extensively investigated. 6 were found to have IgA deficiency. It is suggested that antecedent IgA deficiency may account for the varied reported incidence of severe post-vagotomy diarrhoea and that preoperative screening could reduce the incidence of this complication.
mesh_terms: D000328:Adult; D003165:Complement System Proteins / Q000032:analysis; D003967:Diarrhea / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007408:Intestinal Absorption; D007583:Jejunum / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology*; D014628:Vagotomy
chemical_list: D007070:Immunoglobulin A; D007136:Immunoglobulins; D003165:Complement System Proteins