title: [Pharmacological properties of procaterol, a newly synthesized, specific beta 2-adrenoceptor stimulant. Part II. Effects on the peripheral organs (author's transl)].
abstract: Pharmacological properties of procaterol (PRO) in the peripheral organs were examined in comparison with those of sulbutamol (SAL) and isoproterenol (ISO). PRO slightly enhanced twitch tension of the tibialis anterior muscle but affected little the mono- and poly-synaptic spinal reflexes and ganglionic transmission. PRO depressed spontaneous contractions of the isolated ileum, non-pregnant and pregnant uterus and also the gastrointestinal and uterine movements in vivo. PRO prolonged the time of peroral charcoal transport in the intestine. Potencies of PRO in producing these effects were between those of ISO and SAL except those on the uterus in which PRO was more potent than ISO and SAL. Pro depressed gastric and bile secretion but had no effect on pancreatic secretion. ISO, PRO and SAL reduced resistance of the common carotid, femoral and renal arteries and the relative potencies of PRO and SAL to ISO were significantly less in the renal artery than in the other arteries. In accelerating heart rate in conscious rats and dogs, PRO (p.o. or s.c.) was almost equipotent to SAL. Urine flow, GFR, RPF, free water and osmolar clearance and also excretion of electrolytes were reduced by PRO with the concomitant fall of systemic blood pressure. PRO has no effect on blood coagulation and hemolysis but inhibited carrageenin edema and an increase in permeability of blood vessels induced by acetic acid. PRO had no alpha-adrenolytic, cholinolytic and anti-histaminic effects.
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000779:Anesthetics, Local; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D066298:In Vitro Techniques; D007668:Kidney / Q000502:physiology; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D011247:Pregnancy; D017265:Procaterol; D011817:Rabbits; D051381:Rats; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000318:Adrenergic beta-Agonists; D000779:Anesthetics, Local; D004983:Ethanolamines; D017265:Procaterol