[Metabolism and in vitro binding of several organochlorine and organophosphate pesticides to calf thymus DNA and rat liver microsomal proteins].
The organophosphorus insecticide ethyl-parathion was transformed by rat liver microsomes into metabolites which were bound to calf thymus DNA, in large amount. When the rats were treated by phenobarbital or 3-methylcholanthrene, the metabolite binding to DNA was increased two-fold. By contrast, in the same conditions, the organochlorine insecticides, aldrin, dieldrin and gamma hexachlorocyclohexane (lindane), did not yield metabolites able to bind to DNA and to proteins.
D000452:Aldrin / Q000378:metabolism; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001711:Biotransformation; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004026:Dieldrin / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000378:metabolism; D007306:Insecticides / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010278:Parathion / Q000031:analogs & derivatives / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical
D007306:Insecticides; D011506:Proteins; D008748:Methylcholanthrene; D001556:Hexachlorocyclohexane; D010278:Parathion; D004247:DNA; D004026:Dieldrin; D000452:Aldrin; D010634:Phenobarbital
Métabolisation et fixation in vitro par le DNA de thymus de veau et les protéines microsomiques de foie de rat de quelques pesticides organochlorés et organophosphorés