Evidence for cell-mediated immunity to renal antigens in minimal-change nephrotic syndrome.
A direct lymphocytotoxicity test was used to investigate 12 patients with minimal-change nephrotic syndrome and 12 patients with proliferative glomerulonephritis for cell-mediated immunity against an epithelial cell culture derived from human kidney. Lymphocytes from patients with minimal-change nephritis but not from those with proliferative disease had significantly greater lymphocytotoxicity against the cultures than did lymphocytes from normal controls.
D000937:Antigen-Antibody Reactions; D046508:Culture Techniques; D003601:Cytotoxicity Tests, Immunologic; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007668:Kidney / Q000276:immunology*; D007958:Leukocyte Count; D009404:Nephrotic Syndrome / Q000150:complications / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology