Effects of two antihistaminic compounds (mequitazine, dexchlorpheniramine) on sleep. Sleep distorsion by antihistaminics.
Twelve healthy subjects have been given mequitazine (two 10-milligramme doses a day), dexchlorpheniramine (two 12-milligramme doses a day) and a placebo for seven days, within a cross-over balanced design. If dexchlorpheniramine induces a significant sleep distortion (slowed REM sleep cycle and decreased amount of REM sleep), no similar trend occured with mequitazine, a result that could be dose or time related.
D000328:Adult; D002744:Chlorpheniramine / Q000494:pharmacology; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D002744:Chlorpheniramine