Lysis of tumor cells by antibody and complement. III. Lack of correlation between antigen movement and cell lysis.
The increase in susceptibility to killing by rabbit antibody and guinea pig complement of guinea pig hepatoma cells (line-10), after treatment with certain metabolic inhibitors, did not correlate with the mobility of antigen on the cell surface as measured by indirect immunofluorescence.
D000818:Animals; D000906:Antibodies; D000912:Antibodies, Neoplasm; D000941:Antigens / Q000032:analysis*; D001386:Azides; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology*; D003078:Colchicine; D003165:Complement System Proteins; D003486:Cyanides; D003513:Cycloheximide; D003571:Cytochalasin B; D003601:Cytotoxicity Tests, Immunologic; D003609:Dactinomycin; D005455:Fluorescent Antibody Technique; D005459:Fluorides; D005577:Forssman Antigen; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007461:Iodoacetates; D008113:Liver Neoplasms; D011691:Puromycin; D013194:Staining and Labeling
D000906:Antibodies; D000912:Antibodies, Neoplasm; D000941:Antigens; D001386:Azides; D003486:Cyanides; D007461:Iodoacetates; D003609:Dactinomycin; D003571:Cytochalasin B; D011691:Puromycin; D003165:Complement System Proteins; D005577:Forssman Antigen; D003513:Cycloheximide; D005459:Fluorides; D003078:Colchicine