[The influence of hydroxyethyl starch on blood clotting (author's transl)].
It has been shown in clinical experiments that blood coagulation was delayed by Dextran 60 and Hydroxyethylstarch (HAS). During the postoperative period up to the 2nd postoperative day the measured clotting factors were decreased within the physiological range. Platelet adhesiveness was mainly reduced in the group of Dextran 60 and in the male Hydroxyethylstarch group. A similar effect of haemodilution as seen by haematocrit and blood viscosity results was produced by Dextran 60 and Hydroxyethylstarch. In the electrolyte group the values obtained did not show any significant influence on blood coagulation apart from a light and temporary trend to hypercoagulation during the day of operation.
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D013213:Starch / Q000031:analogs & derivatives*
D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D005340:Fibrinogen; D013213:Starch
Die Beeinflussung der Blutgerinnung durch Hydroxyäthylstärke Eine klinische Vergleichsuntersuchung