The combined use of antilymphocytic serum and bone marrow infusion in immunological suppression.
The combined use of antilymphocytic serum and live donor-specific bone marrow cells has produced significant immunosuppression in dogs as judged by renal allograft survival. This combined action is specific in that it cannot be reprodued whether given alone or when live donor-specific bone marrow cells are replaced by dead donor-specific bone marrow cells or other antigens. The study has paved the way for human trials.
D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002678:Chimera; D004285:Dogs; D004731:Endotoxins / Q000276:immunology; D005260:Female; D006085:Graft Survival; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D004731:Endotoxins