Inhibition of hypersensitivity reactions by soluble derivatives of baicalein.
Baicalein, a flavonoid, is anti-allergic but only slightly soluble in water. The soluble derivatives of baicalein, disodium baicalein-6-phosphate (BPS) and sodium baicalein-6-sulfate (BSS), were synthesized and examined regarding their effects on hypersensitivity reactions. These derivatives inhibited type I and II reactions as classified by Coombs and Gell. The Arthus reaction belonging to type III reaction, however, was hardly affected with either BPS or BSS. The experimental asthma caused by passive systemic anaphylaxis in guinea pigs was prevented with application of BPS. Thus even by the oral route, BPS appears to be clinically applicable to extensive allergy related diseases.
D000628:Aminophylline / Q000627:therapeutic use; D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D000941:Antigens / Q000032:analysis; D001183:Arthus Reaction / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy; D002744:Chlorpheniramine; D005260:Female; D044950:Flavanones; D005419:Flavonoids / Q000627:therapeutic use*; D006168:Guinea Pigs; D006460:Hemolysin Proteins; D006636:Histamine Release; D006967:Hypersensitivity / Q000188:drug therapy*; D007545:Isoproterenol / Q000627:therapeutic use; D008297:Male; D009119:Muscle Contraction; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D010323:Passive Cutaneous Anaphylaxis; D011239:Prednisolone / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D012882:Skin Tests; D012995:Solubility; D013464:Sulfuric Acids / Q000627:therapeutic use; D014867:Water
D000941:Antigens; D044950:Flavanones; D005419:Flavonoids; D006460:Hemolysin Proteins; D009943:Organophosphorus Compounds; D013464:Sulfuric Acids; D014867:Water; D000628:Aminophylline; D002744:Chlorpheniramine; C006680:baicalein; D011239:Prednisolone; D007545:Isoproterenol