Stimulation of arachidonic acid metabolism by human slow-reacting substances.
Human slow-reacting substance of anaphylaxis (SRS-A) and calcium ionophore-induced human SRS released prostaglandin-like substances and rabbit aorta contracting substance (RCS) from guinea-pig lungs. This effect was abolished by incubation of SRS-A and SRS with arylsulphatase or pretreatment of the lungs with indomethacin. Human SRS-A and SRS therefore resembled guinea-pig SRS-A in stimulating arachidonic acid metabolism. These results provide further evidence for a similar (or identical) nature of human SRS-A and SRS and suggest a possible role for slow-reacting substances in the release of prostaglandins during anaphylaxis.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D012898:Autacoids / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology
D001095:Arachidonic Acids; D012898:Autacoids; D011453:Prostaglandins; D013189:SRS-A; D000001:Calcimycin