Bone marrow transplantation for acute leukemia using a histocompatible paternal donor.
A bone marrow transplantation from an HLA-identical, MLC nonreactive paternal donor has been performed in a patient with acute lymphoblastic leukemia resistant to drug treatment. Prompt engraftment was documented; however, the patient died of interstitial pneumonitis due to cytomegalovirus 65 days after transplant. Clinical manifestation of graft-versus-host reaction was mild. Recurrence or persistence of leukemia was found at the time of death using cytogenetic markers and determination of the leukemic marker enzyme terminal deoxynucleotidyl transferase.
D001853:Bone Marrow / Q000201:enzymology; D016026:Bone Marrow Transplantation; D002648:Child; D003586:Cytomegalovirus Infections / Q000209:etiology; D005260:Female; D006087:Graft vs Host Reaction; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007945:Leukemia, Lymphoid / Q000628:therapy*; D007959:Lymphocyte Culture Test, Mixed; D009713:Nucleotidyltransferases / Q000378:metabolism; D011024:Pneumonia, Viral / Q000209:etiology; D012008:Recurrence; D014019:Tissue Donors; D014184:Transplantation, Homologous
D006680:HLA Antigens; D009713:Nucleotidyltransferases