[IgM antibody deficiency with normal serum IgM concentration in a family (author's transl)].
A 5 years old child with selective antibody deficiency having slight hypogammaglobulinaemia of the IgG-class, normal IgM and absence of IgA has been described. The patient had no isoagglutinins and no heteroagglutinins against rabbits. Antibodies of the IgG-class could be detected in a very low concentration. The child had repeated severe infections, f. e. 5 attacks of pneumonia. After diagnosis of selective antibody deficiency syndrome had been made, he has been treated with high dose gammaglobulin therapy every 4 weeks. The child did not have any severe infections since that time. Diagnostic and therapeutic possibilities in patients with selective antibody deficiency were discussed.
D000917:Antibody Formation; D002648:Child; D004406:Dysgammaglobulinemia / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D008297:Male; D005719:gamma-Globulins / Q000627:therapeutic use
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005719:gamma-Globulins
Familiäre Störung der Antikörperbidung im IgM-Bereich bei normaler Konzentration der entsprechenden Globuline