Is there a limbic system equivalent of tardive dyskinesia?
Long-term administration of antipsychotic drugs to animals induces super-sensitive mesolimbic postsynaptic dopamine receptors. It is possible that a similar process can occur in man. Following a reduction in the dose of antipsychotic medications, or their complete discontinuation, mesolimbic dopamine receptor supersensitivity could be reflected in rapid relapse of schizophrenic patients, the development of schizophrenic symptoms in patients with no prior history of schizophrenia, or in the necessity for ever-increasing doses of long-acting depot fluphenazine to maintain a remission.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005476:Fluphenazine / Q000627:therapeutic use; D006801:Humans; D008032:Limbic System / Q000187:drug effects*; D008636:Mesencephalon / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D005476:Fluphenazine