Synthesis of new sulfuric derivatives of allobarbital (5,5-diallylbarbituric acid) with anti-inflammatory activity.
It was found that allyl group of alkenes Ia-Ig is transformed into 3'-sulfo-2'-sulfatopropyl or beta-methyl-beta-sulton groups in reaction of addition under action of concentrated sulfuric acid in the presence of methyl cyanide. It was stated that this reaction is competitive to the Ritter reaction. Soluble in water calcium salts IV obtained from compounds Ia and Ib exhibited strong antiinflammatory activity.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001463:Barbiturates / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry
D000893:Anti-Inflammatory Agents; D001463:Barbiturates