title: Antigenicity and cross-reactivity of denatured fibril proteins of primary, secondary, and myeloma associated amyloids.
abstract: Antisera have been produced against amyloid fibril preparations of primary, secondary, and myeloma origins. These have revealed the presence of both idiotypic and shared antigenic determinants. A high degree of cross-reactivity among the 3 types of amyloid has been found irrespective of classification. One antiserum to a secondary amyloid fibril preparation proved to be directed against A protein (the major nonimmunoglobulin constituent of secondary amyloid fibrils). This antiserum detected A protein in several of the secondary amyloids as well as in two primary amyloid fibril preparations which were degraded with alkali; These finding indicate that amyloid fibrils of various origins have similarities in composition and, therefore, may have common factors involved in fibrillogenesis.
mesh_terms: D000682:Amyloid / Q000276:immunology* / Q000302:isolation & purification; D000686:Amyloidosis / Q000145:classification / Q000209:etiology* / Q000276:immunology; D000906:Antibodies; D000941:Antigens; D002850:Chromatography, Gel; D003429:Cross Reactions; D000939:Epitopes; D005260:Female; D006146:Guanidines; D006801:Humans; D005779:Immunodiffusion; D009101:Multiple Myeloma / Q000150:complications / Q000276:immunology*; D011489:Protein Denaturation; D011506:Proteins / Q000276:immunology*
chemical_list: D000682:Amyloid; D000906:Antibodies; D000941:Antigens; D000939:Epitopes; D006146:Guanidines; D011506:Proteins