title: A myopathy associated with myotonia in the dog.
abstract: The pathology of two cases of canine myopathy associated with myotonia are presented. The changes were interpreted as dystrophic. The most obvious features were a rounding on cross section and variation in fibre size with numerous internal nuclei, many of which formed chains. Degeneration and regeneration were seen and there was a slight increase in perimysial and endomysial connective tissue. Only one ringed fibre was seen, but no sarcoplasmic masses. Enzyme histochemistry failed to demonstrate any selective Type I fibre atrophy. The peripheral and central nervous systems were normal in both cases.
mesh_terms: D000818:Animals; D002467:Cell Nucleus; D003238:Connective Tissue / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D006651:Histocytochemistry; D006818:Hyalin / Q000032:analysis; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D009135:Muscular Diseases / Q000473:pathology / Q000662:veterinary*; D009222:Myotonia / Q000473:pathology / Q000662:veterinary; D009243:NAD / Q000032:analysis; D009336:Necrosis; D009468:Neuromuscular Diseases / Q000662:veterinary; D012038:Regeneration; D013385:Succinate Dehydrogenase / Q000032:analysis
chemical_list: D009243:NAD; D013385:Succinate Dehydrogenase