title: The reaction of the cancerostatic CCNU with the catalytic site of transglutaminase.
abstract: The experiments in this paper show for the first time that CCNU, a nitrosourea, inhibits transglutaminase (an enzyme believed to be involved in tissue proliferation) on account of its cyclohexyl-isocyanate moiety.
mesh_terms: D000818:Animals; D001665:Binding Sites; D003485:Cyanates / Q000494:pharmacology; D006168:Guinea Pigs; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008130:Lomustine / Q000494:pharmacology*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011485:Protein Binding; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D003485:Cyanates; D009607:Nitrosourea Compounds; D008130:Lomustine; D005723:gamma-Glutamyltransferase