Effect of centrally active drugs on dopamine oxidation by rat brain catecholamine oxidase.
Centrally active drugs of the phenothiazine-, butyrophenone- and iminodibenzyl class markedly decreased the rate of dopamine oxidation in the presence of rat brain catecholamine oxidase.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D002746:Chlorpromazine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007700:Kinetics; D011395:Promazine / Q000494:pharmacology; D051381:Rats; D013881:Thioridazine / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology; D014272:Trifluperidol / Q000494:pharmacology
D014150:Antipsychotic Agents; D014268:Trifluoperazine; D004299:Dopamine beta-Hydroxylase; D006220:Haloperidol; D013881:Thioridazine; D011395:Promazine; D007099:Imipramine; D014272:Trifluperidol; D003891:Desipramine; D002746:Chlorpromazine; D004298:Dopamine