Effect of neuroleptic drugs on lithium uptake by the human erythrocyte.
We studied the effects of neuroleptic and antidepressant drugs on Li+ uptake in human red cells to examine the reported neurotoxicity reported for lithium-neuroleptic combination treatment and its relationship to altered tissue Li+ levels. All the phenothiazines increased Li+ influx in red cells and steady-state Li+ distribution ratio in vitro. This effect was not observed with other drugs studied. It is suggested that increased levels of Li+ in the tissue caused by phenothiazines may be related to neurotoxic effects observed during Li+ -phenothiazine therapy.
D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008094:Lithium / Q000097:blood*; D010042:Ouabain / Q000494:pharmacology; D010624:Phenelzine / Q000494:pharmacology; D010640:Phenothiazines; D010693:Phloretin / Q000494:pharmacology; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010640:Phenothiazines; D010042:Ouabain; D008094:Lithium; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D006220:Haloperidol; D010624:Phenelzine; D010693:Phloretin