Effect of hexachlorobenzene on enzymes of the steroid metabolism in rat liver.
Adult female Wistar rats were fed with a diet containing 0.05% hexachlorobenzene. On the 60th day of this treatment the specific activities of NADPH: delta 4-3-oxosteroid-5 alpha-reductase and the 3-hydroxysteroid dehydrogenases in rat liver microsomes were diminished compared to control rats. The cytoplasmatic 5 beta-reduction was higher in HCB treated rats than in control rats. These alterations of the steroid metabolism lead to increased formation of 5 beta-H-steroids which are known to be inducers of the porphyrin biosynthesis.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D002722:Chlorobenzenes / Q000494:pharmacology*; D004032:Diet; D005260:Female; D006581:Hexachlorobenzene / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009249:NADP / Q000378:metabolism; D011162:Porphobilinogen / Q000652:urine; D011166:Porphyrins / Q000652:urine; D051381:Rats; D013256:Steroids / Q000378:metabolism*
D002722:Chlorobenzenes; D011166:Porphyrins; D013256:Steroids; D006581:Hexachlorobenzene; D009249:NADP; D011162:Porphobilinogen; D015096:3-Hydroxysteroid Dehydrogenases