title: A serum protein associated with chromatin of cultured fibroblasts.
abstract: Antibodies to chromatin proteins from human and mouse fibroblasts which have been cultured for more than 25 generations with heterologous serum show specificity for a homologous alpha-serum protein. These results indicate that among the chromatin-associated proteins there is one (or more) which has extensive structural similarity to a serum protein. This is the first direct evidence that a serumlike protein or proteins could be chromatin associated in vivo, as has been suggested by experiments showing in vitro interaction between DNA and certain serum proteins.
mesh_terms: D001665:Binding Sites; D001798:Blood Proteins / Q000276:immunology / Q000378:metabolism*; D002478:Cells, Cultured; D002843:Chromatin / Q000378:metabolism*; D003429:Cross Reactions; D003852:Deoxyribonucleoproteins / Q000276:immunology; D000939:Epitopes; D005347:Fibroblasts
chemical_list: D001798:Blood Proteins; D002843:Chromatin; D003852:Deoxyribonucleoproteins; D000939:Epitopes