Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment.
Intraperitoneal injection of neonatal rats with glucocorticoid hormones causes precocious development of hepatic cytochrome P-450. Glucagon injection fails to stimulate this cytochrome P-450 development. Adult liver cytochrome P-450 is less responsive to glucocorticoid stimulation than is that of neonatal rat liver. Adrenalectomy of prematurely delivered neonatal animals prevents the early postnatal development of cytochrome P-450. Glucocorticoids failed to increase cytochrome P-450 concentrations in foetal rat liver. These findings imply that, although glucocorticoids are mandatory regulatory factors controlling cytochrome P-450 development, they are not themselves the 'trigger' initiating onset of that development.
D000315:Adrenalectomy; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D003345:Corticosterone / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D014444:Tyrosine Transaminase / Q000096:biosynthesis
D003907:Dexamethasone; D005934:Glucagon; D003577:Cytochrome P-450 Enzyme System; D014444:Tyrosine Transaminase; D003345:Corticosterone