Biogenetic origin of the D-isoleucine and N-methyl-L-alloisoleucine residues in the actinomycins.
Studies with (14)C-labeled isoleucine stereisomers have established that l-alloisoleucine, d-alloisoleucine, and d-isoleucine may function as precursors for the biogenesis of d-isoleucine and N-methyl-l-alloisoleucine residues in actinomycin. l-[(14)C]isoleucine appears to be employed chiefly for d-alloisoleucine (and N-methylisoleucine [?] formation); however, its role in the biosynthesis of d-isoleucine and N-methylalloisoleucine remains unclear. The potential pathway of biosynthesis of d-isoleucine and N-methyl-l-isoleucine is discussed.
D000596:Amino Acids / Q000378:metabolism; D003609:Dactinomycin / Q000378:metabolism*; D007532:Isoleucine / Q000031:analogs & derivatives* / Q000378:metabolism*; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism; D013303:Streptomyces antibioticus / Q000378:metabolism; D013997:Time Factors
D000596:Amino Acids; D007532:Isoleucine; D003609:Dactinomycin