Effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo.
Indomethacin decreased Prostaglandin F 2 alpha levels in the ovaries of marmoset monkeys which were treated with PMS/HCG. The production of estradiol and progesterone, however, was unaffected by the blockade in prostaglandin synthesis. The number of ovulations following PMS/HCG treatment was significantly reduced by indomethacin treatment. These observations suggest that prostaglandins are required for follicular rupture but not for progesterone and estradiol production by the ovary.
D000818:Animals; D002143:Callitrichinae; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004958:Estradiol / Q000096:biosynthesis*; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D000882:Haplorhini; D007213:Indomethacin / Q000494:pharmacology*; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D011460:Prostaglandins F; D011374:Progesterone; D004958:Estradiol; D007213:Indomethacin