[Characteristics of the reactions to N-alloantigens of lymphoid cells from hydrocortisone-stimulated and adrenalectomized mice].
The capacity of the spleen, bone marrow and thymus cells from CBA mice (intact, adrenalectomized, and those treated with single or repeated hydrocortisone injections) to induce the lymph node type of "graft-versus-host" reaction (GVHR) in (CBA X C57BL) F1 hybrid recipients was evaluated. Two days after 2.5 mg hydrocortisone injection the capacity of the spleen and bone marrow cells to induce GVHR increased while that of the thymus cells remained unchanged. Seven and particularly 15 days after hydrocortisone injection the spleen cells became less active. Two days following repeated daily hormone injections in a dose of 0.25 mg within 18 days the thymocyte activity in GVHR increased, while that of the spleen and bone marrow cells did not change.
D000311:Adrenal Glands / Q000276:immunology*; D000315:Adrenalectomy; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D006087:Graft vs Host Reaction / Q000187:drug effects; D006854:Hydrocortisone / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D007519:Isoantigens; D006854:Hydrocortisone
Osobennosti reaktsiĭ na N-alloantigeny limfoidnykh kletok stimulirovannykh gidrokortizonom i adrenaléktomirovannykh mysheĭ.