[Removal of the optimizing action of neuroleptics on the avoidance behavior of rats after striatectomy].
In an Y-maze rats easier reformed the trajectory of the behavioral response under the effect of haloperidol (0.05--0.1 mg/kg) and aminazin (0.5--1 mg/kg). A restricted (5--10 per cent of the volume) bilateral electrolytic distruction of the striatum fully suppressed the effect of lower doses of the above compounds both early (7--14th day) and late (28--35th day) after the operation. In large doses the neuroleptics continued to facilitate relearning of the rats in the first 1--2 weeks following striatectomy, but later on this effect also disappeared.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000502:physiology; D002746:Chlorpromazine / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology* / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004564:Electrocoagulation; D004924:Escape Reaction / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D014150:Antipsychotic Agents; D006220:Haloperidol; D002746:Chlorpromazine
Ustranenie optimiziruiushchego deĭstviia neĭroleptikov na izbegatel'noe povedenie krys posle striatéktomii.