Return of spermatogenesis after stopping cyclophosphamide therapy.
A follow-up of twenty-six male patients with azoospermia after stopping cyclophosphamide treatment showed a return of spermatogenesis in twelve patients within 15-49 months (mean 31 months). In one patient spermatogenesis returned despite 34 months of treatment with 100 mg. of cyclophosphamide daily. The period of follow-up after stopping cyclophosphamide therapy varied from 5 months to 4 years. After 6 months on cyclophosphamide all patients remained azoospermic while taking the drug. Return of spermatogenesis was not significantly associated with age, duration of cyclophosphamide therapy, total dose, or time of follow-up after stopping treatment; however, the number of patients in the study was small.
D000328:Adult; D000367:Age Factors; D002452:Cell Count; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000188:drug therapy; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000032:analysis; D013081:Sperm Motility; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000032:analysis / Q000187:drug effects; D013997:Time Factors
D003520:Cyclophosphamide