[The prognosis and treatment of pneumococcal meningitis in Africa. 402 cases (author's transl)].
Over a period of 5 years (1973--1977), 1083 patients were hospitalised in the Infectious Disease Clinic of the Dakar University Hospital Centre with bacteriologically confirmed purulent meningitis. The pneumococcus was responsible in 462 cases (42.6%). Analysis of 402 records showed that 234 patients (58.2% of cases) died, 123 were completely cured (30.6%) whilst there were neurological sequelae in 45 cases (28% of the survivors). The chief factors in poor prognosis were the existence and depth of changes in conscious level, age over 20 years, a CSF cell count of less than 500 per mm3, a CSF protein level greater than 2 g per 1 and I CSF antigen level over 8 microgram per ml. From a therapeutic standpoint, the percentage mortality was similar with chloramphenicol and with penicillin G, but complete cures were statistically more frequent in the patients treated initially with chloramphenicol.
D000293:Adolescent; D000328:Adult; D000349:Africa; D000367:Age Factors; D000368:Aged; D000755:Anemia, Sickle Cell / Q000150:complications; D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use; D003244:Consciousness Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use; D011379:Prognosis; D012640:Seizures / Q000209:etiology; D013156:Splenectomy / Q000009:adverse effects; D013296:Streptococcus pneumoniae / Q000276:immunology
D000942:Antigens, Bacterial; D002556:Cerebrospinal Fluid Proteins; D002701:Chloramphenicol; D010400:Penicillin G
Pronostic et traitement des méningites à pneumocoque en Afrique. 402 observations.