Effect of bilirubin on the distribution, elimination and anticoagulant action of dicumarol in Gunn rats-1-2 (38547).
Jaundiced Gunn rats were found to have a significantly larger apparent volume of distribution and higher rate constant for elimination of dicumarol than their nonjaundiced littermates.  Anticoagulant effect-log plasma dicumarol concentration lines were parallel in the two groups of animals, with the line for the jaundiced rats shifted to a lower concentration range.  In vitro studies showed that bilirubin can displace dicumarol from serum protein binding sites. There are indications of a genetic influence on the distribution and anticoagulant effect of dicumarol in Gunn rats.
D000818:Animals; D001663:Bilirubin / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D001728:Dicumarol / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D007565:Jaundice / Q000378:metabolism; D008297:Male; D011485:Protein Binding; D051381:Rats
D001798:Blood Proteins; D001728:Dicumarol; D001663:Bilirubin