Transformation of BHK 21/13 cells by chemical carcinogens and mutagens.
In vitro transformation of BHK 21/13 cells by chemical carcinogens is reported. The hamster cells were treated with MCA, BP, 4-NQO and 5-azaCR at various concentration and duration of treatment. The morphological, karyological and growth characteristics of cell lines were investigated. Search for RNA tumor viruses in transformed cells using 3H-uridine labeling, detection of DNA polymerases, electron microscopy investigations failed to detect presence of C-type virus particles.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006224:Cricetinae; D008748:Methylcholanthrene / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000209:etiology; D012190:Retroviridae / Q000302:isolation & purification
D001580:Benzopyrenes; D002273:Carcinogens; D009153:Mutagens; D008748:Methylcholanthrene; D015112:4-Nitroquinoline-1-oxide; D001374:Azacitidine