Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile: influence of vagotomy, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones.
Insight into the pathogenesis and etiology of experimental duodenal ulceration was sought by studying the modulation of this disease in rats by selective vagotomy, chemical sympathectomy, histamine depletion, histamine H-2 receptor antagonists (eg, metiamide, cimetidine), or endocrine ablations. Gastric secretion was examined in intact and pylorus-ligated animals. The formation of duodenal ulcers induced by the administration of propionitrile or cysteamine was abolished by vagotomy, decreased by sympathectomy, histamine depletion, histamine H-2 receptor antagonists, hypophysectomy, thyroidectomy, or adrenalectomy. Cimetidine and metiamide exerted a dose-dependent antiulcer effect, but metiamide enhanced the mortality of rats given propionitrile or cysteamine. The non-ulcerogen derivative of cysteamine, ethanolamine, did not increase mortality when given in combination with metiamide. The gastric hyperacidity elicited by cysteamine was reduced by metiamide or vagotomy, the latter being more effective in this respect. Thus, the chemically induced duodenal ulcer in rats resembles the human peptic ulcer disease in sensitivity to therapeutic modalities and may serve as an appropriate model to study the role of neural, hormonal, and other factors in the etiology and pathogenesis of this disorder.
D000315:Adrenalectomy; D000818:Animals; D002369:Castration; D002927:Cimetidine / Q000494:pharmacology*; D003543:Cysteamine; D004195:Disease Models, Animal; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006632:Histamine / Q000502:physiology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007016:Hypophysectomy; D008785:Metiamide / Q000494:pharmacology*; D009570:Nitriles; D051381:Rats; D013562:Sympathectomy; D013890:Thiourea / Q000031:analogs & derivatives*; D013965:Thyroidectomy; D014628:Vagotomy
D006146:Guanidines; D006635:Histamine H2 Antagonists; D009570:Nitriles; D008785:Metiamide; D003543:Cysteamine; D002927:Cimetidine; D006632:Histamine; D013890:Thiourea