Cystic fibrosis heterozygosity in the pathogenesis of allergy.
47% of cystic fibrosis (C.F.) heterozygotes had positive prick skin tests of 1 or more of 9 antigens and 53% had histories of allergic disease, both occurring significantly more often than in a control group. Since 1 in 20 of the population are C.F. carriers, this would contribute to allergy in the community.
D000485:Allergens; D003550:Cystic Fibrosis / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D008297:Male; D012882:Skin Tests
D000485:Allergens