Antigenic characterization of type C RNA virus isolates of gibbon apes.
Type C RNA viruses initially isolated from a lymphosarcoma of a gibbon ape and from a fibrosarcoma of a woolly monkey are very closely related immunologically. However, recent studies have shown that these viruses are distinguishable in a radioimmunoassay for the 12,000-molecular-weight polypeptide (p12) of the woolly monkey virus. In the present report, an immunoassay has been developed for the p12 polypeptide of the gibbon ape type C virus. This assay is shown to further distinguish the woolly monkey and gibbon ape viruses. In type-specific assays for the p12 polypeptides of these viruses, two new type C viruses isolated from gibbons in a second colony, characterized by high incidence of hemopoietic neoplasia, are immunologically distinguishable from the original gibbon ape virus. The p12 type-specific immunoassays described in the present report may be of importance in studying the natural history of these viruses and their relationship to tumors of primates.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D002850:Chromatography, Gel; D000939:Epitopes; D005354:Fibrosarcoma / Q000382:microbiology / Q000662:veterinary; D000882:Haplorhini; D015186:Hominidae; D007457:Iodine Radioisotopes; D007525:Isoelectric Focusing; D008228:Lymphoma, Non-Hodgkin / Q000382:microbiology / Q000662:veterinary*; D008970:Molecular Weight; D008992:Monkey Diseases / Q000382:microbiology; D010455:Peptides / Q000032:analysis; D011863:Radioimmunoassay; D012190:Retroviridae / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification
D000956:Antigens, Viral; D000939:Epitopes; D007457:Iodine Radioisotopes; D010455:Peptides