The contribution of plasma protease inhibitors to antiplasmin activity in man.
1. Human plasma contains a variety of proteins that are capable of inhibiting plasmin activity. Whole plasma possesses 'rapid' and 'progressive' plasmin-neutralizing activity: this study assesses the contribution of individual protease inhibitors to this plasmin-neutralizing property of plasma. 2. Rapid and progressive antiplasmin activities of human plasma correlate with alpha2-macroglobulin and alpha1-antitrypsin concentrations respectively. 3. Fluctuations in the amounts of the other measured inhibitors (antithrombin III, Cl in activator and inter-alpha-tryspin inhibitor) did not influence the measured antiplasmin activity.
D000991:Antithrombins / Q000502:physiology; D001798:Blood Proteins / Q000502:physiology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D006801:Humans; D007700:Kinetics; D014361:Trypsin Inhibitors / Q000502:physiology; D000515:alpha 1-Antitrypsin / Q000502:physiology; D000511:alpha-Macroglobulins / Q000502:physiology
D000991:Antithrombins; D001798:Blood Proteins; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D005341:Fibrinolysin