Methods for evaluation of urinary excretion parameters of alclofenac after I.M. administration of its water soluble lysine salt in man.
The urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cummings. All methods used give similar estimates of both DU infinity and Kel with exception of the "Sigma minus" method when DU infinity obtained by "Rate Method" was utilized. Niebergall's method is preferred on the basis that it provides an accurate estimation of both DU infinity and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.
D000328:Adult; D005965:Glucuronates / Q000652:urine; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D008722:Methods; D010648:Phenylacetates / Q000008:administration & dosage / Q000652:urine*; D013997:Time Factors
D005965:Glucuronates; D010648:Phenylacetates