Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis.
The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.
D000818:Animals; D006224:Cricetinae; D006863:Hydrogen-Ion Concentration; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology*; D008647:Mesocricetus; D003012:Microbial Collagenase; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000503:physiopathology
D003012:Microbial Collagenase