The materno-foetal transfer of carrier protein sensitivity in the mouse.
The anti-dinitrophenol (DNP) antibody response was examined in the 18-week-old offspring of female mice primed to bovine serum albumin (BSA) and in control unprimed animals. Comparisons were made of the response to DNP-BSA, DNP-chicken gamma-globulin (CGG) and DNP-purified protein derivative (PPD) after all offspring had been primed with DNP-CGG at 12 weeks of age. An enhanced anti-DNP antibody response was found to DNP-BSA in mice whose mothers had received BSA. It is suggested that this phenomenon demonstrates the transfer of carrier protein sensitivity from mother to foetus.
D000372:Agglutination Tests; D000704:Analysis of Variance; D000818:Animals; D000917:Antibody Formation; D002352:Carrier Proteins; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006241:Haptens; D007116:Immunization, Passive; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D008431:Maternal-Fetal Exchange; D051379:Mice; D008808:Mice, Inbred CBA / Q000502:physiology*; D009578:Nitrobenzenes / Q000276:immunology; D011247:Pregnancy; D012710:Serum Albumin, Bovine; D014373:Tuberculin; D005719:gamma-Globulins
D002352:Carrier Proteins; D006241:Haptens; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D009578:Nitrobenzenes; D014373:Tuberculin; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine