[Study of prostaglandin synthesis during anaphylactic shock in guinea pigs].
In guinea pigs actively sensitized with ovalbumin and shocked, we have measured blood histamine and histaminase, pulmonary content in cycli AMP and prostaglandins (PG) E1, E2 and F2alpha. In pulmonary efferent blood, both PGE and PGF are increased. In lung tissue, only PGF2alpha, which are bronchoconstructive mediators, are increased. Th increased level in PG seems to have two origins: first a specific increase, then an increased synthesis secondary to histamine release.
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D006636:Histamine Release; D008168:Lung / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000097:blood; D011460:Prostaglandins F / Q000096:biosynthesis* / Q000097:blood; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D006632:Histamine; D000242:Cyclic AMP; D006631:Amine Oxidase (Copper-Containing)
Etude de la synthèse de prostaglandines au cours du choc anaphylactique chez le Cobaye