[Immunogenic properties of DNA from E. coli and T4 phage, containing 5-bromouracil].
5-BUDR incorporated into E. coli or T4 phage DNAs is an immunogenic determinant. Immunodominance of 5-BUDR is determined by the chemical structure of DNA molecule into which it is incorporated. In E. coli DNA, 5-BUDR inhibits immunogenic activity of all other bases. One can conclude that in this DNA 5-BUDR is the dominant antigenic determinant. In T4 DNA, 5-BUDR acts as an additional antigenic determinant. Anti-5-BUDR-T4-DNA contains antibodies to 5-BUDR and glucosylated 5-HMC.
D001973:Bromodeoxyuridine / Q000276:immunology*; D003090:Coliphages / Q000276:immunology*; D004269:DNA, Bacterial / Q000276:immunology* / Q000378:metabolism; D004279:DNA, Viral / Q000276:immunology* / Q000378:metabolism; D000939:Epitopes; D004926:Escherichia coli / Q000276:immunology*
D004269:DNA, Bacterial; D004279:DNA, Viral; D000939:Epitopes; D001973:Bromodeoxyuridine
Immunogennye svoĭstva DNK E. coli i faga T4, soderzhashchikh 5-bromdezoksiuridin