title: Myo-inositol-1-phosphate synthase from streptomyces griseus (studies on the biosynthesis of cyclitols, XXXVIII).
abstract: It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.
mesh_terms: D002238:Carbohydrate Epimerases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008970:Molecular Weight; D009154:Mutation; D007296:Myo-Inositol-1-Phosphate Synthase / Q000302:isolation & purification / Q000378:metabolism*; D013305:Streptomyces griseus / Q000201:enzymology* / Q000235:genetics
chemical_list: D002238:Carbohydrate Epimerases; D007296:Myo-Inositol-1-Phosphate Synthase