Occurrence of alpha-1-fetoprotein in the mammary gland tissue of men with gynecomastia.
Immunohistochemical proof of A1FP production in the mammary gland of a man with gynecomastia is published here for the first time. The immunohistochemical proof of this fetal alpha-1-globulin in the intraductal epithelium of the mammary gland is described on the basis of the case history of a 25-year-old man with a metastasizing malignant teratoblastoma of the gonads. The question, to what extent A1FP-neosynthesis is characteristic for malignant tumors or whether it is a cellular response to specific, in this case hormonal growth stiumli of primary tumors, is also discussed.
D000328:Adult; D001940:Breast / Q000378:metabolism*; D005326:Fetal Proteins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006177:Gynecomastia / Q000209:etiology / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D013724:Teratoma / Q000150:complications / Q000378:metabolism*; D013736:Testicular Neoplasms / Q000150:complications / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000378:metabolism*
D005326:Fetal Proteins; D000509:alpha-Fetoproteins