Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.
The effect of preimmunization of CBA/H mice with M locus and H-2 incompatible lymphocytes was examined on the in vitro generation of cytotoxic cells to both types of targets. Preimmunization with M locus did not help to generate cytotoxic cells to M-locus targets; however, the anti-H-2 cytotoxicity of M-locus-preimmunized lymphocytes was suppressed between the 6th and 19th day after preimmunization. In contrast, preimmunization with H-2 incompatibility produced an amplified lytic anti-H-2 response. The possible mechanisms are discussed.
D000818:Animals; D002874:Chromosome Mapping; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005260:Female; D005796:Genes; D006680:HLA Antigens; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D007114:Immunization; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens