Influenza at Christ's Hospital: March, 1974.
Boys in a boarding-school given inactivated influenza-A or influenza-B vaccine have been observed during a simultaneous outbreak of influenza due to A/Port Chalmers, B/Hong Kong, and B/Intermediate strains. Influenza-B vaccine conferred substantial protection, the attack-rates in boys given B vaccine being 24% compared with 45% in a control group. A/Hong Kong vaccine, by preventing infection during the previous influenza A/England outbreak, left the boys vulnerable to influenza A/Port Chalmers. Influenza-A haemagglutination-inhibiting (H.I.) antibody acquired by natural infection was associated with more protection than H.I. antibody induced by vaccination. This difference was not seen with influenza-B H.I. antibody.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D002648:Child; D002986:Clinical Trials as Topic; D004196:Disease Outbreaks / Q000453:epidemiology*; D004739:England; D005500:Follow-Up Studies; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D009975:Orthomyxoviridae / Q000276:immunology; D011446:Prospective Studies; D012572:School Health Services
D000914:Antibodies, Viral; D007252:Influenza Vaccines