Mechanism of axonal transport: a proposed role for calcium ions.
In vitro axonal transport of tritiated protein decreased 40 to 60 percent when neuronal cell bodies were incubated in calcium-free medium, but was not affected when only nerve trunks were exposed to calcium-free conditions. In addition, calcium-45 was transported along axons at a rate similar to that of rapidly transported tritiated protein. These data are interpreted to suggest that calcium ions are involved in the initiation of axonal transport and in the coupling of transported proteins to the transport system.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D002132:Calcium Radioisotopes; D005727:Ganglia, Spinal / Q000378:metabolism; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011892:Rana catesbeiana; D012584:Sciatic Nerve / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D013127:Spinal Nerves / Q000378:metabolism; D014316:Tritium
D002132:Calcium Radioisotopes; D009419:Nerve Tissue Proteins; D014316:Tritium; D007930:Leucine; D002118:Calcium