[Action of ketamine of paroxysmal discharges provoked by air emboli in the baboon Papio papio].
Ketamine was administered to 18 baboons (Papio papio) to disrupt epileptic discharges elicited through intracarotid air injection. Discharge suppression was obtained in all animals but could be preceded by a phase of enhancement of the epileptic patterns, which rendered necessary the injection of a supplementary dose. The mechanisms of Ketamine action are discussed, in connection with data from the literature. Some of the latter suggest that its use in proved epileptics facilitates paroxystic patterns or even convulsions while others emphasize its antiepileptic action. Present data corroborate the ambivalent action of this drug. However, its dominant depressant effect obtained with increasing doses is somewhat favourable to its administration to epileptic patients.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000627:therapeutic use; D004569:Electroencephalography; D004618:Embolism, Air / Q000150:complications*; D000882:Haplorhini; D002542:Intracranial Embolism and Thrombosis / Q000150:complications*; D007427:Intracranial Pressure / Q000187:drug effects; D007649:Ketamine / Q000009:adverse effects / Q000627:therapeutic use*; D010215:Papio; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
D007649:Ketamine; D003975:Diazepam
Action de la kétamine sur les décharges paroxystiques provoquées par embolie aerique chez le babouin Papio-papio