Biological significance of Fc receptor-bearing cells among activated T lymphocytes.
Lethally irradiated mice injected with syngeneic thymocytes and immunized with protein antigens develop specific helper T cells. If injected with semiallogeneic thymocytes, such mice generate H-2 antigen-specific cytotoxic T cells. Most spleen cells from these chimeric mice possess Fc receptors. The present results demonstrate that the development of Fc-receptor-bearing cells in thymocyte-injected irradiation chimeras seemingly is due to the physiological conditions in the mice rather than to the specific immunization. As a corollary, both helper T cells and cytotoxic T cells did not have Fc receptors, at least not in their effector state. Thus, Fc receptors on T cells would seem irrelevant to their immune function.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody / Q000528:radiation effects; D002455:Cell Division; D000939:Epitopes; D007106:Immune Sera; D007114:Immunization; D007141:Immunoglobulin Fc Fragments; D008213:Lymphocyte Activation / Q000528:radiation effects*; D051379:Mice / Q000276:immunology; D008815:Mice, Inbred Strains; D011817:Rabbits / Q000276:immunology; D011830:Radiation Effects; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects / Q000637:transplantation; D014184:Transplantation, Homologous
D000939:Epitopes; D007106:Immune Sera; D007141:Immunoglobulin Fc Fragments