title: Inhibition by estramustine phosphate on estradiol and androgen binding in benign and malignant prostate in humans.
abstract: Specific cytoplasmic androgen and estrogen binding has been measured in human benign prostatic hypertrophy and carcinomatous tissue. In vitro support for the binding of estramustine phosphate (Estracyt) to both estradiol- and dihydrotestosterone-binding sites is presented, which in part could explain the clinical effect of estramustine phosphate when pure estrogenic compunds are not effective.
mesh_terms: D000728:Androgens / Q000378:metabolism*; D001665:Binding Sites; D003593:Cytoplasm / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D004961:Estramustine / Q000378:metabolism / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*
chemical_list: D000728:Androgens; D004967:Estrogens; D009588:Nitrogen Mustard Compounds; D004961:Estramustine; D004958:Estradiol