title: Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications.
abstract: Nitrosomethylurea (MNU) was tested with the tetrazolium test for skin carcinogens with positive results. 39 hairless mice were painted once a week with a 1% solution of MNU in acetone. After 18 weeks all the animals bore tumours and 90% had skin carcinomas. Hence, the strong carcinogenic potency of MNU was confirmed, and the validity of the tetrazolium test was given further support.
mesh_terms: D000818:Animals; D002273:Carcinogens; D008770:Methylnitrosourea / Q000009:adverse effects* / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000139:chemically induced*; D013778:Tetrazolium Salts
chemical_list: D002273:Carcinogens; D009607:Nitrosourea Compounds; D013778:Tetrazolium Salts; D008770:Methylnitrosourea