Studies on the prevalence of type C virus associated with gibbon hematopoietic neoplasms.
Gibbon malignancy frequently involves the hematopoietic system and can occur in clusters. Virus isolated from gibbon neoplasms possessed typical type C virus morphology, and the virion measured 100 nm in diameter with an electron-dense nucleoid measuring approximately 75 nm. The virus incorporated 3H-uridine into the nucleic acid and rested at a buoyant density of 1.14-1.16 g/cm3. Intra-and interspecific antigenic determinants were present, and the intraspecific antigenic determinant was shared with the woolly monkey sarcoma virus but not with feline or murine type C viruses. The virus and antibody reactive to the virus are more prevalent in gibbon groups that experience leukemia than those free of hematopoietic neoplasms.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D000939:Epitopes; D000882:Haplorhini; D015186:Hominidae; D006922:Hylobates; D007938:Leukemia / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification*
D000956:Antigens, Viral; D000939:Epitopes