Identification of cholecystokinin-secreting cells.
Cholecystokinin (C.C.K.)-producing cells were identified in the mucosa of the upper small intestine in man and other mammals by immunocytochemical techniques and electron microscopy on semi-thin and serial thin sections. Ultrastructural studies suggested that the C.C.K.-producing cells resemble I cells of the modified Wiesbaden classification. The combination of these techniques provides a simple and reliable method of identifying C.C.K. cells in human biopsy material and will be useful in the investigation and diagnosis of gut endocrine dysfunctions.
D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D004285:Dogs; D004386:Duodenum / Q000166:cytology / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D007082:Ileum / Q000166:cytology / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000166:cytology*; D007421:Intestine, Small / Q000166:cytology*; D007583:Jejunum / Q000166:cytology / Q000648:ultrastructure; D013270:Stomach / Q000166:cytology / Q000648:ultrastructure; D013552:Swine
D002766:Cholecystokinin