title: A novel class of antitumour agents. I. Chemistry and animal experiments.
abstract: Newly synthesized tertiary amino steroids, among them 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP), were tested in three animal species as to their antitumour activity against transplantable tumours. The acute toxicity of DAP was similar to that of cyclophosphamide and considerably lower than vinblastine. Rats with Walker ascites, treated intraperitoneally with DAP, survived up to one year without ascites; untreated animals died within 10 days of transplantation. Intragastric and intraperitoneal application of DAP caused side effects suggesting a local toxicity.
mesh_terms: D000588:Amines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006224:Cricetinae; D003520:Cyclophosphamide / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D008647:Mesocricetus; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010197:Pancuronium / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012517:Sarcoma, Yoshida / Q000188:drug therapy; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D013256:Steroids; C015172:2,16-dipiperidinoandrostane-3,17-diol dipivalate; D003520:Cyclophosphamide; D010197:Pancuronium