Differential feulgen-deoxyribonucleic acid hydrolysis patterns of Herpes simplex virus type 1 and type 2 infected cells.
Infection of human embryonic lung cells with herpes simplex virus type 1 (HSV-1) and herpes simplex type 1 (HSV-2) resulted in: (a) qualitative (nuclear cytopathologic) alterations and quantitative (nuclear area) differences in infected compared to control nuclei; (b) increased Feulgen-deoxyribonucleic acid (F-DNA) amounts in infected cells, probably due to viral DNA; (c) higher F-DNA levels in HSV-2 infected cells; and (d) increased rates of F-DNA hydrolysis in viral-infected as compared to uninfected nuclei.
D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis* / Q000648:ultrastructure; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D008168:Lung / Q000196:embryology; D018139:Simplexvirus / Q000032:analysis*; D013194:Staining and Labeling; D013997:Time Factors
D004279:DNA, Viral