Adaptive changes in the dopamine system produced by chronic ethanol feeding.
The consumption of ethanol by mice resulted in an altered sensitivity of the brain dopamine systems to perturbations produced by agonists and antagonists. The results indicate that ethanol feeding and withdrawal produces a state in which the normal coupling between dopamine receptors and the effectors for these receptors is significantly altered.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000096:biosynthesis; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D010868:Pimozide / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D013375:Substance Withdrawal Syndrome; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D011954:Receptors, Dopamine; D010868:Pimozide; D000431:Ethanol; D004295:Dihydroxyphenylalanine; D014446:Tyrosine 3-Monooxygenase; D000262:Adenylyl Cyclases; D001058:Apomorphine