Accelerated fall in serum bromide level after administration of perchlorate to man.
Five patients intoxicated with bromoureide showed accelerated elimination of bromide from serum after a single dose of perchlorate. It was probably due to increased renal excretion of bromide. Perchlorate has been reported to increase the renal clearance of other monovalent anions by inhibiting their tubular reabsorption and a similar interaction between perchlorate and bromide is suggested. Although perchlorate effectively eliminates bromide it should not replace chloride in the treatment of bromide intoxication, because of the side effects of its repeated administration.
D000328:Adult; D000368:Aged; D001965:Bromides / Q000097:blood*; D003864:Depression, Chemical; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010472:Perchlorates / Q000494:pharmacology*; D013997:Time Factors; D014508:Urea / Q000378:metabolism / Q000506:poisoning
D001965:Bromides; D010472:Perchlorates; D014508:Urea