title: Effect of histamine H2-receptor antagonists on concentration of noradrenaline, dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid in rat brain.
abstract: Intraventricular (ivt) administration of 50 micrograms of burimamide (BUR) or 250 micrograms of either metiamide (MET) or cimetidine (CIM) decreased noradrenaline (NA) concentration in the rat hypothalamus by nearly 30%. CIM did not significantly influence either dopamine (DA) or 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the striatum. Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) contents in the hypothalamus were not significantly affected by either MET or CIM.
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002049:Burimamide / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008785:Metiamide / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism
chemical_list: D006635:Histamine H2 Antagonists; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008785:Metiamide; D006897:Hydroxyindoleacetic Acid; D002927:Cimetidine; D002049:Burimamide; D004298:Dopamine; D009638:Norepinephrine