title: [Chronology of the extrapyramidal effects of neuroleptics, and the nigrostriatal dopaminergic system].
abstract: Authors after analysis of the data in literature describe the chronologic appearance of the extrapyramidal effects of neuroleptics. In order to restore a neurophysiological coherence to dissimilar or even contradictory clinical emergences this sequence is analysed in function of the actual data, relative to the mechanism and to the modalities of adaptation of the dopaminergic synapse of the nigro striatal system.
mesh_terms: D017109:Akathisia, Drug-Induced; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000503:physiopathology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000502:physiology; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D004298:Dopamine
vernacular_title: Chronologie des effets extra-pyramidaux des neuroleptiques et système dopaminergique nigro-striatal.