Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D010879:Piperazines; D008694:Methamphetamine; D006639:Histidine