Neuronal localisation of benzodiazepine receptors in cerebellum.
The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the cerebllum of mutant nervous mouse (nr/nr) where Purkinje cells are degenerated but in the mutant weaver mouse where granule cells are degenerated. These results show that benzodiazepine receptors are located mainly on neurons; both on Purkinje cells and other neurons, but not to a great extent on granule cells.
D000818:Animals; D014151:Anti-Anxiety Agents; D002531:Cerebellum / Q000032:analysis* / Q000166:cytology / Q000187:drug effects; D005445:Flunitrazepam; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D009457:Neuroglia / Q000032:analysis; D009474:Neurons / Q000032:analysis; D051381:Rats; D011955:Receptors, Drug / Q000032:analysis*
D014151:Anti-Anxiety Agents; D011955:Receptors, Drug; D005445:Flunitrazepam; D007608:Kainic Acid