Effect of various factors on induction of liver tumors in animals by the alpha-isomer of benzene hexachloride.
The tumorigenic effect of a diet containing the alpha-isomer of benzene hexachloride (alpha-BHC) on the liver of various animals was examined. It was found that alpha-BHC induced liver tumors in male and female mice but not in rats or hamsters in the present observations. Histological changes in the liver of mice induced by alpha-BHC were also much greater than those induced in rats or hamsters. Male animals were more susceptible to the tumorigenic action of alpha-BHC than females. Among different strains of mice, the DDY showed greatest susceptibility and the C57BL/6 showed the least. Induction oflpha-BHC was not inhibited by concomitant feeding of 1-naphthyl isothiocyanate or p- hydroxypropiophenone. However, 3-methylcholanthrene slightly inhibited their induction by alpha-BHC.
D000818:Animals; D001835:Body Weight; D002273:Carcinogens / Q000008:administration & dosage; D006224:Cricetinae; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000494:pharmacology; D006910:Hydroxypropiophenone / Q000008:administration & dosage / Q000494:pharmacology; D007536:Isomerism; D008099:Liver / Q000033:anatomy & histology / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008748:Methylcholanthrene / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity; D013861:Thiocyanates / Q000008:administration & dosage
D002273:Carcinogens; D013861:Thiocyanates; D006910:Hydroxypropiophenone; D008748:Methylcholanthrene; D001556:Hexachlorocyclohexane