The assay and stability of chlorpropamide in solid dispersion with urea.
Thin layer chromatography followed by reflectance densitometry has been used to evaluate the stability of chlorpropamide-urea during the fusion process. Urea was found to decompose to biuret and chlorpropamide to p-chlorobenzenesulphonamide: several other unidentified decomposition products were detected. The energy for decomposition of chlorpropamide was 57.1 kJmol-1 for melts containing 15 and 30% chlorpropamide. Decomposition followed apparent first order kinetics.
D002747:Chlorpropamide / Q000032:analysis*; D004355:Drug Stability; D005079:Excipients; D013696:Temperature; D013997:Time Factors; D014508:Urea
D005079:Excipients; D014508:Urea; D002747:Chlorpropamide