title: Gallstone dissolution in man using cholic acid and lecithin.
abstract: Seven patients with radiolucent  stones in the gallbladder and two patients with radiolucent stones in the biliary tree were treated with oral cholic acid and purified soya-bean lecithin for 6 months. In two patients the stones disappeared and in one patient the stones were reduced in size. In five patients fasting bile samples were obtained before and during treatment and assayed for cholesterol, bile acid, and phospholipid. In all five patients the lithogenic index of bile was reduced during treatment. The biliary deoxycholic acid concentration was increased and chenodeoxycholic acid concentration decreased during treatment.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis; D002769:Cholelithiasis / Q000188:drug therapy*; D002793:Cholic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D042882:Gallstones / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000627:therapeutic use*; D013025:Glycine max
chemical_list: D001647:Bile Acids and Salts; D002793:Cholic Acids; D010713:Phosphatidylcholines