title: The effect of repetitive stimulation on the passive electrical properties of the presynaptic terminal of the squid giant synapse.
abstract: The resting electrical properties of the presynaptic terminal of the squid giant synapse have been determined by using constant current pulses. After short periods of repetitive stimulation, the terminal resistance, time constant and capacitance are found to be increased. These changes are absent in terminals bathed in artificial sea water containing no calcium, and sea water containing 5 mM cobalt. It seems likely that these changes are associated with transmitter release.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D003035:Cobalt / Q000494:pharmacology; D049832:Decapodiformes; D004558:Electric Stimulation; D007811:Lanthanum / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009411:Nerve Endings / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D013570:Synaptic Membranes / Q000502:physiology*; D013997:Time Factors
chemical_list: D018377:Neurotransmitter Agents; D003035:Cobalt; D007811:Lanthanum; D002118:Calcium