title: Doxantrazole, an antiallergic agent orally effective in man.
abstract: In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunteer patients challenged with specific antigen.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D051381:Rats; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013892:Thioxanthenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D044004:Xanthones
chemical_list: D013777:Tetrazoles; D013892:Thioxanthenes; D044004:Xanthones; C010134:doxantrazole