title: Solitary myeloma. A study of 10 black patients during an 8-year period.
abstract: Solitary myeloma of bone occurred in 10 Black patients during the 8-year period from 1967 to 1974. In 4 patients, the solitary myeloma involved the bones of the paranasal sinuses, in 3 patients the pelvis, and in 3 others the manubrium sterni. An IgG monoclonal gammopathy was present in the serum of 4 patients and Bence-Joanes proteinuria was found in 1 patient. Radiation therapy was the treatment of choice and the recommended tumour dosage is 4000-5000 rads. Serial measurements of serum and urine protein electrophoresis and immuno-electrophoresis were most helpful in determining when patients had achieved a complete remission. In 3 patients, 1 of whom died, the myeloma disseminated in periods varying from 26 months to 7 years. Nine patients are alive, of whom 7 are in complete remission, and 5 have lived for more than 5 years since the initial diagnosis of solitary myeloma.
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D001536:Bence Jones Protein; D044383:Black People; D001796:Blood Protein Disorders / Q000150:complications; D001859:Bone Neoplasms / Q000150:complications / Q000401:mortality / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008371:Manubrium; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms; D010386:Pelvic Neoplasms; D010954:Plasmacytoma / Q000150:complications / Q000401:mortality / Q000532:radiotherapy; D011507:Proteinuria / Q000150:complications; D011879:Radiotherapy Dosage; D013019:South Africa; D005719:gamma-Globulins
chemical_list: D005719:gamma-Globulins; D001536:Bence Jones Protein