Pharmacological properties of axonal sodium channels in the cockroach Periplaneta americana L. II. Slowing of sodium current turn-off by Condylactis toxin.
Condylactis toxin induces a prolonged falling phase in action potentials recorded from giant axons of the cockroach Periplaneta americana L. A distinct plateau potential can be recorded in the presence of Condylactis toxin at concentrations of 0.5 mg/ml and above. In cockroach axons, voltage-clamp experiments show that Condylactis toxin acts primarily by slowing the sodium current turn-off without affecting either the time-course of the sodium conductance increase or the peak amplitude of the transient sodium current.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000187:drug effects*; D003064:Cnidarian Venoms / Q000494:pharmacology*; D003058:Cockroaches / Q000502:physiology*; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010526:Periplaneta / Q000502:physiology*
D003064:Cnidarian Venoms; D007473:Ion Channels