title: [The effect of fluoridated phenylethanolamines on hyperglycemia induced by catecholamines in the rat].
abstract: 10 compounds from the 2.4- and 3.4-difluorinated phenylethanol-amines series were tested for their antagonistic action against a hyperglycemia induced by catecholamines in rats, and the ED50 and AD50 values were determined. All the substances acted beta-adrenolytically, with the glycogenolysis enhanced by isoproterenol being blocked more potently by 3.4-difluorophenylethanolamines than by the corresponding 2.4-difluoroderivatives. An exception in the series is 2.4-difluoro-n-butylnoradrenalin, which acts 10fold more beta-adrenolytically than the 3.4-difluoroderivative, and has 3 times the effect of the comparative substance dichloroisoproterenol.
mesh_terms: D000818:Animals; D002395:Catecholamines; D004336:Drug Antagonism; D004837:Epinephrine / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010626:Phenylethyl Alcohol; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
chemical_list: D002395:Catecholamines; D004983:Ethanolamines; D011433:Propranolol; D007545:Isoproterenol; D010626:Phenylethyl Alcohol; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine
vernacular_title: Wirkung fluorierter Phenyläthanolamine auf eine durch Katecholamine induzierte Hyperglykämie bei Ratten