title: Methotrexate nephrotoxicity.
abstract: The use of high dose methotrexate therapy in the treatment of malignant disease has been complicated by nephrotoxicity. Analysis of the basic physico-chemical properties of methotrexate has allowed the development of improved techniques of administering methotrexate, at high dose, which greatly reduces the incidence of nephrotoxicity.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects*; D008727:Methotrexate / Q000494:pharmacology / Q000633:toxicity*; D012995:Solubility
chemical_list: D008727:Methotrexate