Suppressor adherent phagocytic cells in solid tumors: a postulated escape mechanism.
A localized graft-versus-host reaction was used to assess the cellular immunity of mice supporting progressive growth of an allogeneic tumor. It was found that early in tumor development anti-tumor-cellular-mediated immunity was hyper-responsive, and that adherent phagocytic cells isolated from the neoplasm would inhibit the specific immunological response. Based on these observations and indirect inference it was postulated that a major factor in the success of an immunogenic tumor is the coterminous development of a normal adherent phagocytic cell population which specifically nullifies, in situ, cellular-mediated anti-tumor immunity.
D000818:Animals; D000951:Antigens, Neoplasm; D002448:Cell Adhesion; D006087:Graft vs Host Reaction; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D010587:Phagocytosis; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm