Immune complexes in skin of NZB/NZW mice.
Skin biopsies were performed on female (NZB X NZW)F1 mice (B/W) at ages ranging from 1 to 12 months. The control strain was the C57B1/6. Immunoglobulin G and beta 1C globulin deposition was sought using the indirect immunofluorescence method. Both globulins were detected consistently at the dermal-epidermal junction from the age of 6 months. The pattern of staining was granular, and progressed from focal deposition to confluent and diffuse involvement of the basement membrane at 9-10 months of age. No staining was observed in any of the C57B1/6 mice up to 14 months of age. These findings increase the resemblance of B/W disease to human systemic lupus erythematosus.
D000818:Animals; D000936:Antigen-Antibody Complex; D001485:Basement Membrane / Q000276:immunology; D001609:Beta-Globulins; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D006824:Hybridization, Genetic; D007074:Immunoglobulin G; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB; D012867:Skin / Q000276:immunology*
D000936:Antigen-Antibody Complex; D001609:Beta-Globulins; D007074:Immunoglobulin G