Combination chemothereapy with cis-diamminedichloroplatinum (II) and bleomycin in tumors of the head and neck.
28 patients with head and neck tumors not suitable for definitive treatment with radiation or surgery were treated with cis-diamminedichloroplatinum (II) and bleomycin in combination. Of 24 adequately treated patients, there were 3 partial remissions lasting for 3,3 and 6 months, respectively. Toxicity of the regimen as given was substantial; 13 patients showed some evidence of nephrotoxicity and there were 2 drug deaths related to progressive renal failure. 1 patient developed bleomycin pulmonary toxicity.
D058186:Acute Kidney Injury / Q000139:chemically induced; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006311:Hearing Disorders / Q000139:chemically induced; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D007958:Leukocyte Count; D008171:Lung Diseases / Q000139:chemically induced; D009325:Nausea / Q000139:chemically induced
D001761:Bleomycin; D002945:Cisplatin