Antibodies to double-stranded (native) DNA in active chronic hepatitis.
Sera from 36 patients with active chronic hepatitis were studied for the presence of antibodies to double-stranded (native) DNA. These antibodies are a specific antinuclear antibody previously shown to have a high degree of specificity for systemic lupus erythematosus. Fifteen of the 36 patients (42%) were found to have levels of antibody usually only reported in systemic lupus erythematosus and higher than those seen in a control population. Anti-DNA antibodies were not found in a group of 22 patients with other forms of liver disease.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D000936:Antigen-Antibody Complex; D001666:Binding Sites, Antibody; D002908:Chronic Disease; D004247:DNA / Q000276:immunology*; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D008107:Liver Diseases / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008928:Mitochondria / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology; D009504:Neutrophils
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D004247:DNA