Hepatic microsomal N-hydroxylation of p-chloroaniline and p-chloro-N-methylaniline in red-winged blackbird compared with rat.
1. N-Hydroxylation of p-chloroaniline (PCA) and p-chloro-N-methylaniline (PCMA) was measured in red-winged blackbird (Agelaius phoeniceus) and rat (Rattus norvegicus) hepatic microsomes. 2. Redwing hepatic microsomes N-hydroxylated PCA slower than rat microsomes. Furthermore, redwing hepatic microsomes had marginal or no ability to N-hydroxylate PCMA, whereas rat hepatic microsomes N-hydroxylated PCMA at a higher rate than PCA. 3. The bird hepatic microsomes had only low or marginal N-demethylase activity with PCMA, whereas the rat hepatic microsomes could N-demethylate PCMA at a higher rate than they could N-hydroxylate it.
D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D001717:Birds / Q000378:metabolism*; D003640:Dealkylation; D006863:Hydrogen-Ion Concentration; D006900:Hydroxylation; D008658:Inactivation, Metabolic; D007700:Kinetics; D008862:Microsomes, Liver / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; C011716:4-chloro-N-methylaniline; D010089:Oxidoreductases, N-Demethylating; C004658:4-chloroaniline