[Heparin and the heparin-precipitated human blood plasma fraction in the rosette formation reaction].
Experiments were conducted on CBA mice. The effect of heparin and of the fraction of human blood plasma precipitated by heparin (FPH) on the course of the specific immunity reaction, i.e. of rosette-formation, was studied. Inhibition of the mentioned reaction by FPH was revealed. No such effect was produced by heparin. Experiments were carried out in vitro. The results of the mentioned experiments were compared with literature data on the effect of heparin and FPH on other immunological reactions. A supposition was put forward that these substances interacting with lymphocytes had different points of application: heparin-cellular membrane, FPH-superficial cell receptors.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001798:Blood Proteins / Q000276:immunology*; D006493:Heparin / Q000276:immunology*; D006801:Humans; D006824:Hybridization, Genetic; D007104:Immune Adherence Reaction; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology; D013997:Time Factors; D005719:gamma-Globulins / Q000494:pharmacology
D001798:Blood Proteins; D005719:gamma-Globulins; D006493:Heparin
Geparin i geparinosazhdaemaia fraktsiia plazmy krovi cheloveka v reaktsii rozetkoobrazovaniia