Cross reactivity between H-2K and H-2D products. II. Identification of the cross reacting specificities.
Absorption analyses were conducted on antisera which had previously been shown to detect cross reactivity between the H-2K and H-2D gene products. These analyses revealed that the cross reactions were due to known public H-2 specificities. Identification of cross reactive anti-H-2.3 and anti H-2.5 antibodies confirmed earlier predictions that genes controlling these specificities should be localized at opposite ends of the H-2 complex. The finding of H-2.29 activity on both sides of the S region clarified ambiguities encountered in assigning this specificity to certain recombinant types. Results with H-2.36 support the suggestion that this determinant may also be specified by both H-2K and H-2D genes.
D000042:Absorption; D000818:Animals; D000918:Antibody Specificity; D003429:Cross Reactions; D000939:Epitopes; D006649:Histocompatibility Antigens / Q000032:analysis* / Q000145:classification; D051379:Mice; D008815:Mice, Inbred Strains; D014176:Protein Biosynthesis
D000939:Epitopes; D006649:Histocompatibility Antigens