Specific B-cell antigens associated with gluten-sensitive enteropathy and dermatitis herpetiformis.
Gluten-sensitive enteropathy (G.S.E.) and dermatitis herpetiformis (D.H.) are associated with an increased frequency of the histocompatability antigen HLA-B8. These diseases were found to be even more strongly associated with a specific B-lymphocyte surface antigen recognised by maternal antisera. Two antisera (B-1 and W-1) reacted with B lymphocytes form G.S.E. and D.H. patients. Antiserum B-1 reacted with cells from thirteen of sixteen G.S.E. patients and from fifteen of nineteen D.H. patients, while antiserum W-1 reacted with cells from fifteen of sixteen G.S.E. patients and from fifteen of fifteen D.H. patients. None of the sera tested reacted with B lymphocytes from thirty-seven normal individuals, whether or not they were HL8-B8 positive. The identification of this specific antigen provides further insight into the pathogenesis of G.S.E. and D.H. and might form the basic of a diagnostic test for these diseases.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D002648:Child; D003874:Dermatitis Herpetiformis / Q000235:genetics / Q000276:immunology*; D000939:Epitopes; D005260:Female; D005983:Glutens / Q000276:immunology; D006680:HLA Antigens / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D007106:Immune Sera; D007158:Immunologic Techniques; D008875:Middle Aged
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007106:Immune Sera; D005983:Glutens