Lymphocytotoxic antibodies in systemic lupus erythematosus and clinically related diseases.
Sera from patients with systemic lupus erythematosus (SLE) and clinically related diseases were examined for cold-reactive lymphocytotoxic antibodies (LCA). The incidence of LCA was significantly increased in SLE (93%), discoid lupus (50%), and "lupus-like" syndromes associated with congenital complement deficiencies (63%) as compared to normal controls (3%) and patients with drug-induced lupus (11%), mixed connective tissue disease (MCTD) (17%), and necrotizing vasculitis (19%). The diagnostic and pathogenetic implications of these differences are discussed.
D000961:Antilymphocyte Serum / Q000032:analysis; D003165:Complement System Proteins / Q000172:deficiency*; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000276:immunology*; D008947:Mixed Connective Tissue Disease / Q000276:immunology*; D010488:Polyarteritis Nodosa / Q000276:immunology*
D000961:Antilymphocyte Serum; D003165:Complement System Proteins