Organic anion and cation transport in vitro by dog choroid plexus: effects of neuroleptics and tricyclic antidepressants.
Dog lateral choroid plexus accumulates the cation 14C-emepronium and the divalent anion 125I-iodipamide in vitro. At 10 micron, high potency neuroleptics with a substituted piperazine side chain and also haloperidol depress only the uptake of the cation and even stimulate the uptake of the anion. In contrast, at 1--10 micron, the accumulation of both test substances is inhibited by neuroleptics and tricyclic antidepressants with an aliphatic side chain. Such unspecific effects on seemingly unrelated transport systems at concentrations reached clinically in the CSF might explain some side actions of low potency neuroleptics and antidepressants.
D000818:Animals; D000838:Anions; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002412:Cations; D002831:Choroid Plexus / Q000378:metabolism*; D004285:Dogs; D004629:Emepronium / Q000378:metabolism*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007458:Iodipamide / Q000378:metabolism*; D007465:Iodohippuric Acid / Q000378:metabolism*; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*
D000838:Anions; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D002412:Cations; D010879:Piperazines; D000644:Quaternary Ammonium Compounds; D004629:Emepronium; D007465:Iodohippuric Acid; D006220:Haloperidol; D007458:Iodipamide