Effects of bunitrolol (Koe 1366) on the distribution of underperfused coronary blood flow.
The effects of a beta-blocker (bunitrolol, Koe 1366) on the distribution of myocardial blood flow from the underperfused left circumflex coronary artery were examined by tracer microsphere method. Koe 1366 increased subendocardial/subepicardial flow ratio without increase of a net flow in the underperfused left ventricle.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D008863:Microspheres; D011412:Propanolamines / Q000494:pharmacology*; D013997:Time Factors
D011412:Propanolamines