title: Studies on the control of pineal indole synthesis: cyclic nucleotides, adenylate cyclase and phosphodiesterase.
abstract: An overview of the biochemical events that occur when postsynaptic pineal beta-adrenergic receptors are stimulated is presented. Emphasis is placed on the importance of the adenylate cyclase system for the induction of N-acetyltransferase (NAT). Super- and subsensitive responses of NAT to receptor agonists are related to cAMP concentration, adenylate cyclase and phosphodiesterase activities and receptor binding sites.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000123:Acetyltransferases / Q000096:biosynthesis; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002940:Circadian Rhythm; D004790:Enzyme Induction; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010870:Pineal Gland / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D000318:Adrenergic beta-Agonists; D009712:Nucleotides, Cyclic; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000123:Acetyltransferases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases