[Effect of the nutrient medium components on the formation of growth inhibition zones of the test microbe in determining the biological activity of mycoheptin].
The effect of the nutrient medium components on the diffusion properties of mycoheptin and the growth of Candida utilis as the test-microbe was studied. It was found that the content of various amounts of sodium and potassium chlorides, disubstituted sodium phosphate, glucose, yeast extract, peptone, agar-agar and the value of pH in the medium had a significant effect on the size of the inhibition growth zones of the test-culture, clearance of their margin and the angle of the dose-response curve. The nutrient medium composition considered to be optimal for determination of the mychoheptin activity is proposed.
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects / Q000254:growth & development*; D003470:Culture Media / Q000494:pharmacology*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D011090:Polyenes / Q000494:pharmacology
D000935:Antifungal Agents; D003470:Culture Media; D011090:Polyenes
Vliianie komponentov pitatel'noĭ sredy na obrazovanie zon zaderzhki rosta test-mikroba pri opredelenii biologicheskoĭ aktivnosti mikogeptina.