[A method for the study of relations between the lung and the reticulo-endothelial system].
The experiments reported in this paper draw attention to three new facts : 1) the reticulo-endothelial system (RES) of normal Rat can be " filled " with a non toxic, polymeric substance, PVNO, which is taken up by macrophages by pinocytosis ; 2) a broncho-pulmonary irritation leads to a discharge of PVNO by the macrophage. The macrophages are poured out into the blood stream, whence they arrive in to the lung ; 3) this discharge of a polymer as PVNO which has been previously taken in the macrophage, can happen even 10-12 months after the filling of the RES by the macromolecule.
D000818:Animals; D005260:Female; D005620:Freund's Adjuvant; D007275:Injections, Intravenous; D007700:Kinetics; D008168:Lung / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D009585:Nitrogen Dioxide / Q000494:pharmacology; D010587:Phagocytosis; D010873:Pinocytosis; D011144:Polyvinylpyridine N-Oxide; D051381:Rats; D005719:gamma-Globulins
D005719:gamma-Globulins; D005620:Freund's Adjuvant; D011144:Polyvinylpyridine N-Oxide; D009585:Nitrogen Dioxide
Méthode d'étude de la dynamique des relations poumon - systéme réticulo-endothélial