The interaction of antibodies to two myelin proteins.
Antibody has been prepared to a hydrophobic myelin protein in rabbits using several different adjuvants. This antibody was found to react with the myelin basic protein. This latter activity could be absorbed out with basic protein leaving the reactivity to the hydrophobic protein, suggesting that the two myelin proteins shared a common antigenic determinant. In addition, the hydrophobic protein appears to possess a unique antigenic determinant.
D000042:Absorption; D000818:Animals; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D004589:Electrophoresis, Disc; D006168:Guinea Pigs / Q000276:immunology; D000882:Haplorhini / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000302:isolation & purification; D004676:Myelin Basic Protein / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology; D011817:Rabbits / Q000276:immunology
D000906:Antibodies; D007106:Immune Sera; D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins