title: Premedication for elective Caesarean section.
abstract: Four coded, but otherwise unidentified, premedicants were prescribed in randomised order for 219 patients who were to undergo elective Caesarean section. Seventy-six (35%) of these patients affirmed at the pre-operative visit that they were not anxious. Diazepam 5 mg and lorazepam 1 mg appeared to be superior to the placebo and to 10-6 ml of 90% alcohol in inducing calmness and/or drowsiness, although the differences were not statistically significant. The incidence of awareness or unpleasant dreams was considerably higher in the placebo and alcohol series (6.2% and 7.5%) than in the diazepam and lorazepam series (nil and 2.1%). There was no remarkable difference in the condition of the immediate newly-born related to the premedicant received by the mother, any small differences being much less impressive than that related to the duration of the U-D interval. No notable differences were observed in the long term conditions between the infants in the placebo, alcohol and diazepam series but the incidence of "reluctance to feed". If relief from preoperative anxiety-and possibly a reduction in the likelihood of awareness-without undue effect upon the infant is considered desirable, diazepam 5 mg is the preferred choice from the four drugs investigated.
mesh_terms: D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D014151:Anti-Anxiety Agents; D001034:Apgar Score; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D003975:Diazepam; D000431:Ethanol; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008140:Lorazepam; D011229:Preanesthetic Medication; D011247:Pregnancy; D011897:Random Allocation
chemical_list: D014151:Anti-Anxiety Agents; D000431:Ethanol; D008140:Lorazepam; D003975:Diazepam