title: Compatibility of high doses of both oral domperidone and neuroleptics in chronic psychotics.
abstract: Twenty chronic schizophrenic inpatients who were being treated with high doses of neuroleptics and of whom seven had extra-pyramidal symptoms in spite of anti-Parkinsonian therapy, were given oral domperidone (50 mg t.d.s. for 2 weeks) for the relief of chronic dyspepsia. The dyspepsia symptoms were markedly improved, no side effects were seen and, even at high doses, domperidone did not intensify the existing extra-pyramidal side effects of the neuroleptics or produce new ones.
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004347:Drug Interactions; D004415:Dyspepsia / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D014150:Antipsychotic Agents; D001562:Benzimidazoles; D010880:Piperidines