Review of clinical studies on clobazam.
1 Clobazam was compared with placebo and diazepam in 45 double-blind studies. 2 Clobazam dosage ranged from 5 mg daily (paediatric patients) to 120 mg daily (psychiatric in-patients). Usual daily dosage in out-patient therapy ranged from 20-30 mg clobazam. 3 Treatment duration varied from a few days up to 3.5 years. The usual duration of treatment was 2-4 weeks. 4 Clobazam was shown to be an efficacious and well tolerated anxiolytic agent in various neurotic and psychosomatic disorders. 5 Dosages showing distinct anxiolytic effects in out-patient therapy did not impair psychomotor performance.
D000328:Adult; D000437:Alcoholism / Q000188:drug therapy; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy; D001008:Anxiety Disorders / Q000188:drug therapy; D002648:Child; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D011602:Psychophysiologic Disorders / Q000188:drug therapy; D011618:Psychotic Disorders / Q000188:drug therapy; D012893:Sleep Wake Disorders / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D013997:Time Factors
D014151:Anti-Anxiety Agents; D003975:Diazepam