Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode.
Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hour period. Lactulose significantly reduced the colonic pH to 5.37 +/- .39 from a fasting value of 6.77 +/- .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
D000818:Animals; D000863:Antacids / Q000494:pharmacology* / Q000627:therapeutic use; D003106:Colon / Q000187:drug effects*; D004187:Disaccharides / Q000494:pharmacology*; D004567:Electrodes, Implanted; D006501:Hepatic Encephalopathy / Q000188:drug therapy; D006863:Hydrogen-Ion Concentration; D007792:Lactulose / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009355:Neomycin / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D000863:Antacids; D004187:Disaccharides; D007792:Lactulose; D009355:Neomycin