Effect of a vaccination programme on the distribution of rubella antibodies in women of  childbearing age.
Results of routine rubella hemagglutination-inhibiting antibody tests on 39,005 serum samples showed that 9-5% of women of childbearing age in the Leeds region were seronegative, and a further 9-2% had low antibody titres of 1/8 or 1/16.  Since routine rubella vaccination of schoolgirls began in 1970 the frequency of seronegative women in the fifteen to nineteen year age group has fallen by 5-7%.  Clinical rubella was confirmed serologically in 140 women, 58 of whom were pregnant.  30 of these pregnancies were terminated, 2 resulted in spontaneous abortions, and 26 proceeded to term.  One infant had congenital rubella.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000302:isolation & purification*; D003168:Complement Fixation Tests; D004739:England; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007110:Immunity, Active; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control; D011296:Prenatal Diagnosis; D012409:Rubella / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000008:administration & dosage; D012412:Rubella virus / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination
D000914:Antibodies, Viral; D012411:Rubella Vaccine