[Receptor substances of brain mitochondria sensitive to neuromediators].
The action of some neurotransmitters and their derivatives on succinate dehydrogenase and cytochrome oxidase of rat brain mitochondria was studied in vitro. Alpha--adrenoreceptor blocking agents phentolamine and dibenzyline abolished the inhibitory action of the native forms of catecholamines (norepinephrine, epinephrine, isoproterenol) on the enzymatic activity under study. Relationships among catecholamines, cyclic 3',5'--AMP, and cortisone in their influence on these enzymes were studied. The data obtained indicate the existence of alpha--type adrenoreceptors in the brain mitochondria which can be responsible for the regulatory influences of catecholamines on functional activity of mitochondria.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D003348:Cortisone / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D003576:Electron Transport Complex IV / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008928:Mitochondria / Q000032:analysis* / Q000187:drug effects / Q000201:enzymology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D012701:Serotonin / Q000494:pharmacology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D011433:Propranolol; D000242:Cyclic AMP; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D007545:Isoproterenol; D001058:Apomorphine; D003348:Cortisone; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine
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