[Allergic reactions following dextrane infusions (author's transl)].
14 allergic reactions to dextran 60 and dextran 75 are reported. In 8 patients the peripheral pulse became impalpable; Medical history and clinical examination did not reveal any predisposition. Histamine liberation is to be discussed. Antihistamines did not protect against allergic reactions of colloid plasma expanders. All the patients were treated with prednisolone and fluids. After rapid infusion of Ringer-lactate and plasma protein solution to an amount of 2000-2775 ml adequate circulation was restored.
D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000188:drug therapy; D001775:Blood Circulation / Q000187:drug effects; D001798:Blood Proteins / Q000627:therapeutic use; D002648:Child; D003911:Dextrans / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006636:Histamine Release; D006801:Humans; D007275:Injections, Intravenous; D007773:Lactates / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000009:adverse effects; D011239:Prednisolone / Q000627:therapeutic use; D011674:Pulse / Q000187:drug effects; D013927:Thrombosis / Q000517:prevention & control
D001798:Blood Proteins; D003911:Dextrans; D006634:Histamine H1 Antagonists; D007773:Lactates; D010952:Plasma Substitutes; D011239:Prednisolone
Allergische Reaktionen nach Dextraninfusionen