A serum factor in aspirin intolerance disease.
Direct and indirect intradermal serum challenge with aspirin intolerant sera in both aspirin tolerant and intolerant patients demonstrated a heat, cold and storage stable serum factor capable of inducing acute anti-hemostatic effects and in some aspirin intolerant patients exacerbation of brief induced clinical symptoms. The data supports a hypothesis for possible induced, conformationally altered gamma globulin resulting from low molecular weight chemical exposures such as aspirin with ensuing recognition by a genetically determined subpopulation of B-lymphocytes with surface membrane receptors avid for the Fc portion of altered gamma globulin or some conformationally altered gamma globulin fraction leading to immune and/or interprotein complexes with subsequent alterations of adrenergic, cholinergic and/or metabolic pharmacologic pathways.
D001241:Aspirin / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D004342:Drug Hypersensitivity / Q000097:blood* / Q000503:physiopathology; D004361:Drug Tolerance; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D012709:Serum Albumin; D005719:gamma-Globulins
D012709:Serum Albumin; D005719:gamma-Globulins; D001241:Aspirin