Immunofluorescent studies of the skin in mixed cryoglobulinaemia and Schönlein-Henoch purpura.
Immunofluorescence investigations in patients with mixed cryoglobulinaemia, Schönlein-Henoch purpura and purpuric allergic reaction with disseminated intravascular coagulation have been performed. In the lesional skin from 8 patients with mixed cryoglobulinaemia, granular vascular deposits of immunoglobulins of the same classes as those of the circulating cryoglobulins were detectable in all cases; complement and fibrinogen were concomitantly present. In the unaffected skin, IgM and complement were detected in the walls of the capillaries. In the early purpuric lesions from 6 patients with Schönlein-Henoch syndrome and from a patient with diseeminated vascular coagulation from acute allergic reaction to phenylbutazone, deposits of fibrinogen occurred mainly in the vessel walls.
D003450:Cryoglobulins / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D010265:Paraproteinemias / Q000276:immunology*; D012867:Skin / Q000276:immunology*
D003450:Cryoglobulins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M