[The hypnotic effect of the new benzodiazepine derivative lormetazepam when given intravenously (author's transl)].
1. 7 groups of 3 healthy male volunteers each, at the age of 21--27 years received various doses of Lormetazepam (0.0635 to 4.0 mg/70 kg). -- 2. The drug was injected intravenously during 60 s. Before, during and up to 4 hours after the injections the EEG, eye-movements, ECG and respiration was recorded and blood pressures measured at given time intervals. -- 3. The vigilo-somnograms showed after the injections a change in the EEG-stages, indicating a reduction of alertness, transitions into reduced wakefulness or beginning stages of sleep. Corresponding to clinical signs one can speak with i.v. applied doses of 0.0635 to 0.5 mg/70 kg of tranquilizing, with 1 mg/70 kg of sedative and with 2--4 kg of hypnotic effects. There has been a good dosage-efficiency relation. -- 4. Side-effects or unwarranted symptoms have not been seen during the clinical observations.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004569:Electroencephalography; D005133:Eye Movements / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008140:Lorazepam / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D012119:Respiration / Q000187:drug effects
D014151:Anti-Anxiety Agents; D008140:Lorazepam
Der hypnotische Effekt des neuen Benzodiazepinderivates Lormetazepam nach intravenöser Injektion.