Cytogenetics analysis of meiotic chromosomes of irradiated mice and their progeny after treatment with streptomycin and dihydrodeoxystreptomycin.
The purpose of this investigation is to find out whether streptomycin and the related compound dihydrodeoxystreptomycin have any mutagenic effect and whether they both are capable of recovering X-ray induced chromosomal translocations in mouse spermatogonia of directly treated animals and their progeny of the first generation. The cytological findings show the absence of any mutagenic effect in animals nonirradiated and treated with streptomycin and dihydrodeoxystreptomycin. The frequency of chromosomal translocation after total irradiation was 9,07%; in animals treated with streptomycin following irradiation 5.13%, and in those irradiated and treated with dihyrodeoxystreptomycin, 3.70%. Male offsprings, originated from parents treated only with antibiotics show no chromosomal translocations. However, offsprings originated from irradiated and treated parents gave birth to the male offspring with chromosomal translocations.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects; D004096:Dihydrostreptomycin Sulfate / Q000031:analogs & derivatives*; D005854:Germ Cells / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008809:Mice, Inbred C3H; D009153:Mutagens; D010084:Oxidation-Reduction; D010375:Pedigree; D011830:Radiation Effects; D011837:Radiation-Protective Agents; D013307:Streptomycin / Q000494:pharmacology*
D009153:Mutagens; D011837:Radiation-Protective Agents; C011771:deoxydihydrostreptomycin; D004096:Dihydrostreptomycin Sulfate; D013307:Streptomycin