title: [Variations of the concentrations of certain glycoproteins in maternal serum, fetal serum and amniotic fluid during pregnancy (author's transl)].
abstract: The authors investigated systematically the variations during normal pregnancies of the concentrations of alpha-1-antitrypsin, orosomucoid, transferrin and alpha-fetoprotein simultaneously in maternal serum, fetal serum and amniotic fluid. The role of certain factors such as the gestational age birth weight, placental weight and pairty were studied with regard to variations in the concentrations of each of these proteins. This research permitted the definition during pregnancy of the normal concentrations for these four proteins and allowed us to learn more about protein exchanges between fetal blood, maternal blood and amniotic fluid. There exists a difference between the concentrations of alpha-1-antitrypsin and of orosomucoid found for primigravidae and for multigravidae. The role of these glycoproteins in preventing the mother from rejecting the fetus (insofar as the fetus may be considered as an allograft) is discussed.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D001724:Birth Weight; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009929:Organ Size; D009961:Orosomucoid / Q000378:metabolism; D011247:Pregnancy; D014168:Transferrin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D009961:Orosomucoid; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins
vernacular_title: Variations des concentrations de certaines glycoprotéines au niveau du sang maternel, foetal et du liquide amniotique lors de la grossesse