Effects of some adrenergic blockers on the abstinence syndrome of addicts to drugs and alcohol.
Pyrroxand and butyroxan -- original drugs possessing hyghly selective alpha-adreno-blocking action at peripheral and central level-relieve symptoms of abstinence syndrome caused by narcotics and other addicting drugs. On the basis of these data it is suggested that adrenergic structures of the brain play a key role in eliciting the abstinence syndrome.
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000437:Alcoholism / Q000534:rehabilitation*; D000818:Animals; D002415:Cats; D004146:Dioxanes / Q000008:administration & dosage / Q000627:therapeutic use*; D004147:Dioxins / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D011759:Pyrrolidines / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000534:rehabilitation*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D004147:Dioxins; D011759:Pyrrolidines; C009143:proroxan