Antivibrionic activity of some glycolytic cycle enzymes of animal cells.
The antivibrionic activity of crystalline preparations of five enzymes of the glycolytic cycle of animals cells was investigated. Phosphorylase "a" (0.5 mg/ml), aldolase (15 mg/ml) and pyruvate kinase (0.1 mg/ml) were found to inhibit the proliferation of Vibrio cholerae cells; phosphoglucomutase and glyceraldehyde-3-phosphate dehydrogenase at a concentration of 0.25 mg/ml were found to be vibriocidal. A mixture of these enzymes containing 0.062 mg/ml of phosphorylase "a" and 0.125 mg/ml of each phosphoglucomutase, aldolase, glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase showed vibriocidal activity.
D000900:Anti-Bacterial Agents; D005634:Fructose-Bisphosphate Aldolase / Q000494:pharmacology*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera / Q000494:pharmacology; D010733:Phosphoglucomutase / Q000494:pharmacology*; D010762:Phosphorylase a / Q000494:pharmacology*; D006005:Phosphorylases / Q000494:pharmacology*; D011770:Pyruvate Kinase / Q000494:pharmacology*; D014734:Vibrio cholerae / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D007106:Immune Sera; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010762:Phosphorylase a; D006005:Phosphorylases; D011770:Pyruvate Kinase; D005634:Fructose-Bisphosphate Aldolase; D010733:Phosphoglucomutase