Lethal irradiation: treatment with immune cell populations.
Lethally irradiated mice have been successfully treated by the inoculation of allogeneic spleen cell populations, without the development of a secondary graft-versus-host (GVH) reaction. This has been accomplished by eliminating those cells responsible for GVH reaction, using a density gradient ultracentrifugation technique. The therapeutic potential for this technique is great. It may well provide a modus operandi to treat patients exposed to otherwise lethal doses of radiation, as well as facilitate therapy of patients with cancer and immune deficiency diseases.
D000818:Animals; D016026:Bone Marrow Transplantation; D002458:Cell Fractionation; D002499:Centrifugation, Density Gradient; D006085:Graft Survival; D006087:Graft vs Host Reaction; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D016038:Skin Transplantation; D013154:Spleen / Q000637:transplantation*; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic