[Effect of papaverine on H+ transport in suspension of cat brain mitochondria].
The intravenous administration of papaverin (3 mg/kg) under conditions of acute experiments showed that it is able to induce a considerable increase in intensity of H+ release from mitochondria of the cat brain tissue cells. Taking into consideration the data of previous researches testifying to the fact taht under the papaverine influence there occurs H+ accumulation in cells due to metabolism intensification, it may be suppose that an intensified release of H+ from the mitochondria plays a definite role in vasodilation of the brain by stimulation of the vessels H+-sensitive receptors.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002415:Cats; D005260:Female; D006863:Hydrogen-Ion Concentration; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010208:Papaverine / Q000494:pharmacology*
D010208:Papaverine
Vliianie papaverina na transport H+ v suspenzii mitokhondriĭ mozga koshek.