title: Investigations on d-galactosamine hepatitis after pretreatment with alpha-hexachlorocyclohexane.
abstract: D-Galactosamine hepatitis cannot be induced in rapidly replicating liver tissue at various times after induction of proliferation. Proliferation was induced by administration of alpha-hexachlorocyclohexane. The morphological features of galactosamine hepatitis do not appear or are very mild. The onset of DNA synthesis is delayed to about 12 hrs as also shown in partially hepatectomized rats.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000097:blood; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005688:Galactosamine / Q000037:antagonists & inhibitors / Q000506:poisoning*; D001556:Hexachlorocyclohexane / Q000008:administration & dosage*; D008099:Liver / Q000473:pathology; D009929:Organ Size; D011292:Premedication; D051381:Rats; D013012:Sorbitol; D014500:Uracil Nucleotides / Q000378:metabolism
chemical_list: D014500:Uracil Nucleotides; D013012:Sorbitol; D001556:Hexachlorocyclohexane; D005688:Galactosamine; D004247:DNA; D000429:Alcohol Oxidoreductases