The effect of morphine and some other narcotic analgesics on brain tryptophan concentrations.
An acute dose of morphine increased brain tryptophan in mice. This effect was not prevented by naloxone nor was it produced by other narcotic analgesics. Dextrorphan, but not levorphanol, had a similar effect to morphine. A large dose of tryptophan had no effect on the antinociceptive action of morphine in mice. Morphine increased brain tryptophan in rats. This effect was prevented by naloxone. A large dose of tryptophan antagonised the antinociceptive action of morphine in the rat.
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003917:Dextrorphan / Q000494:pharmacology; D005260:Female; D007981:Levorphanol / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D014364:Tryptophan / Q000378:metabolism*
D000701:Analgesics, Opioid; D003917:Dextrorphan; D007981:Levorphanol; D009270:Naloxone; D009020:Morphine; D014364:Tryptophan