Quantitative analysis of amineptine (S-1694) in biological samples by gas chromatography--mass fragmentography.
A sensitive, specific method for the quantitative analysis of amineptine in rat blood and brain is described. After extraction and purification amineptine is detected by mass fragmentography, monitoring the fragment ion at m/e 192. The method allows the quantitative analysis of as little as 50 ng of amineptine per ml blood and 200 ng per g for brain.
D000818:Animals; D001921:Brain / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000032:analysis* / Q000378:metabolism; D003986:Dibenzocycloheptenes / Q000032:analysis* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D007700:Kinetics; D008297:Male; D008722:Methods; D051381:Rats
D000697:Central Nervous System Stimulants; D003986:Dibenzocycloheptenes