Fast and slow axoplasmic flow in sciatic nerve of diabetic rats.
Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin-treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20% and ChAc accumulation by about 40%. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000123:Acetyltransferases / Q000378:metabolism*; D000208:Acute Disease; D000818:Animals; D001370:Axonal Transport; D001786:Blood Glucose / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D003929:Diabetic Neuropathies; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D008026:Ligation; D008297:Male; D051381:Rats; D012584:Sciatic Nerve / Q000201:enzymology / Q000503:physiopathology*; D013311:Streptozocin
D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin; D005934:Glucagon; D000123:Acetyltransferases; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase