Cell-mediated cytotoxicity against murine cells infected with 6/94 virus, a parainfluenza type 1 isolate from multiple sclerosis brain tissue.
Maximum cytotoxicity to parainfluenza type 1 viral determinants occurs on day 5 post-immunization in mice with and without preexisting anti-6/94 virus antibody. Animals with preexisting anti-6/94 serum antibody, however, exhibited a markedly higher cytotoxic response. Syngeneic, allogeneic, and xenogeneic virus-infected cells induce virus-specific cytotoxicity, but only infected cells histocompatible with the effector cells can serve as susceptible target cells. The effector cell is a T cell, and hence cytotoxicity is thymus dependent. Coincident with the maximum cytotoxic activity on day 5 is the occurrence of pathological lesions, the sites of which are dependent on the route of inoculation.
D000596:Amino Acids; D000818:Animals; D000918:Antibody Specificity; D000956:Antigens, Viral; D001921:Brain / Q000382:microbiology; D002474:Cell-Free System; D002490:Central Nervous System / Q000473:pathology; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006648:Histocompatibility; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009103:Multiple Sclerosis / Q000276:immunology*; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014764:Viral Proteins / Q000096:biosynthesis
D000596:Amino Acids; D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins