[Modification of curarization after acute administration of 2 antiepileptic drugs].
In rats anaesthetised with sodium pentobarbital the previous administration of a single dose of an anti-epileptic agent (carbamazepine or sodium valproate) significantly increases the curarising action of two short-action curare-like agents--pancuronium bromide and fazadinium bromide. It seems that this potentialisation of curare action might be the result of either a pharmacokinetic interference (competion for plasma protisen receptor sites), or due to a summation of depressor actions at the neuromuscular level, especially through changes in the levels of GABA and/or cAMP.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D000242:Cyclic AMP / Q000502:physiology; D004357:Drug Synergism; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use*; D010197:Pancuronium / Q000627:therapeutic use; D010424:Pentobarbital / Q000627:therapeutic use*; D011726:Pyridinium Compounds / Q000627:therapeutic use; D051381:Rats; D014635:Valproic Acid / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000927:Anticonvulsants; D003473:Neuromuscular Nondepolarizing Agents; D011726:Pyridinium Compounds; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000242:Cyclic AMP; D010424:Pentobarbital; D010197:Pancuronium
Modifications de la curarisation après administration aiguë de deux antiépileptiques.