title: R factors in gentamicin-resistant organisms causing hospital infection.
abstract: An abrupt increase in gentamicin-resistant isolates was noted in the Manhattan Veterans Administration Hospital in 1973 and 1974. Bacteraemic infection occurred in 17 patients, 9 of whom died. R factors mediating gentamicin resistance were demonstrated in 34 of 36 strains. Organisms from 9 of 11 patients transferred a resistance pattern common to all other isolates from that patient, suggesting in-vivo interbacterial spread of the R factor.
mesh_terms: D000328:Adult; D000368:Aged; D003428:Cross Infection / Q000209:etiology / Q000382:microbiology*; D004352:Drug Resistance, Microbial / Q000187:drug effects*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005839:Gentamicins / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011549:Pseudomonas / Q000302:isolation & purification; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011815:R Factors / Q000187:drug effects*; D018805:Sepsis / Q000209:etiology / Q000382:microbiology
chemical_list: D005839:Gentamicins