Rat tumour allografts evoke anaphylactic antibody responses.
In vitro assays of release of histamine from peritoneal mast cells showed that Wistar rats produced anaphylactic antibody in response to a single immunization with an allogeneic sarcoma. The response occurs early after immunization, and no adjuvant is needed. The thermolability of the anaphylactic antibody suggests that it is IgE.
D000276:Adjuvants, Immunologic; D000707:Anaphylaxis; D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D000917:Antibody Formation; D001202:Ascitic Fluid / Q000166:cytology; D001886:Bordetella pertussis / Q000276:immunology; D005354:Fibrosarcoma / Q000276:immunology*; D006632:Histamine / Q000032:analysis; D006636:Histamine Release; D006358:Hot Temperature; D007114:Immunization; D007073:Immunoglobulin E; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000276:immunology; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology; D014184:Transplantation, Homologous
D000276:Adjuvants, Immunologic; D000912:Antibodies, Neoplasm; D007073:Immunoglobulin E; D006632:Histamine