Increased urinary excretion of albumin, light chains, and beta2-microglobulin after intravenous arginine administration in normal man.
Infusion of 60 g of arginine in six healthy men over a 40-50 min period caused a 16-fold increase in the excretion-rate of albumin from 8-6 to 142-4 mug/min. After injection of 3, 6, 9, and 12 g of arginine the mean albumin-excretion rate of another six normal subjects rose from 5-8 mug/min to 9-4, 13-2, 21-6, and 33-9 mug/min, respectively. Excretion of light chains of immunoglobulin increased from 5-5 mug/min to 18-0, 30-0, 40-5; and 52-0 mug/min, respectively, and the excretion rate of beta2-microglobulin increased from 0-092 mug/min to 2-97, 9-23, 16-39, and 25-71 mug/min. Thus a clear dose response pattern was found. The results strongly suggest that the mechanism behind the arginine-induced protein excretion is an inhibition of tubular reabsorption.
D000419:Albuminuria / Q000139:chemically induced*; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D001609:Beta-Globulins / Q000652:urine*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000652:urine*; D007263:Infusions, Parenteral; D008297:Male; D011507:Proteinuria / Q000209:etiology*; D001613:beta 2-Microglobulin / Q000652:urine*
D001609:Beta-Globulins; D007147:Immunoglobulin Light Chains; D001613:beta 2-Microglobulin; D001120:Arginine