Formation of an infectious virus-antibody complex with Rous sarcoma virus and antibodies directed against the major virus glycoprotein.
Preparations of Rous sarcoma virus (RSV) can form an infectious viral-antibody complex with antibodies raised against the major glycoprotein, gp85, isolated from avian myeloblastosis virus and Prague-RSV subgroup C. Binding of anti-gp85 antibodies to RSV can be demonstrated by the inhibition of focus-forming activity after addition of goat anti-rabbit immunoglobulin and by a shift in density of virions treated with anti-gp85 serum. Group- rather than subgroup- specific regions of viral gp85 appear to be the site of binding for infectious complex.
D000818:Animals; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D009189:Avian Myeloblastosis Virus / Q000276:immunology; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D001666:Binding Sites, Antibody; D000939:Epitopes; D011817:Rabbits / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000939:Epitopes; D014764:Viral Proteins