Effect of histamine on uterine vasculature in rats.
The effects of histamine infusions on the rat uterine vasculature have been studied using the radioactive microsphere technique. Histamine produced a marked uterine vasodilatation which could be partly mimicked by infusion of either the H1-receptor agonist, 2-(2-aminoethyl)pyridine, or the H2-receptor agonist, 4-methyl-histamine. Histamine-induced uterine vasodilatation could only be reduced significantly by administration of a combination of the H1- and H2-receptor antagonists mepyramine and metiamide but not by either antagonist given alone. It was concluded that histamine-induced vasodilatation in the rat uterus is mediated by both H1- and H2-receptors.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002369:Castration; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014599:Uterus / Q000098:blood supply*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D006632:Histamine; D011433:Propranolol