title: Acute effects of smoking tobacco and a tobacco substitute on lung function in man.
abstract: The acute effects on airway function of smoking one cigarette of a tobacco substitute 'New Smoking Material' (NSM), one cigarette of conventional tobacco, and one cigarette containing 70% tobacco and 30% NSM, were studied in 6 healthy nonsmokers and 6 healthy smokers. None of the cigarettes produced any change in three tests of small-airway function (flow-volume curves, closing volume, frequency dependence of compliance). However, smoking either one conventional tobacco cigarette or the 30% NSM/70% tobacco cigarette produced an acute fall in specific airways conductance, of similar degree with both cigarettes, whereas the 100% NSM cigarette produced no such change.
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D009538:Nicotine / Q000032:analysis; D010947:Plants, Toxic; D012129:Respiratory Function Tests; D012907:Smoking / Q000503:physiopathology*; D013638:Tars / Q000032:analysis; D013997:Time Factors; D014026:Nicotiana; D014797:Vital Capacity
chemical_list: D013638:Tars; D009538:Nicotine