title: Cell-mediated immunity to moloney sarcoma virus in mice. I. Analysis of antigens responsible for lymphocyte stimulation in regressor mice.
abstract: Purified viruses, viral antigens, and cell extracts have been tested for their ability to stimulate protein synthesis by MSV-M-1 regressor spleen cells from BALB/c mice. Immune, but not normal cells, responded to MSV-M, but not to MSV-G virus-1, and to the type-specific viral envelope glycoprotein from MSV-M virus. Extracts of mouse embryo fibroblasts transformed by either MSV-M or MSV-G, however, specifically stimulated MSV-M regressor spleen cells. Cells stimulated by different antigens, and by phytohaemagglutinin, had the same sedimentation profile and were identified as T-lymphocytes.
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D002460:Cell Line; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D003470:Culture Media; D004591:Electrophoresis, Polyacrylamide Gel; D004622:Embryo, Mammalian; D000939:Epitopes; D005347:Fibroblasts / Q000276:immunology; D006023:Glycoproteins / Q000032:analysis; D007106:Immune Sera / Q000494:pharmacology; D007111:Immunity, Cellular; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus / Q000032:analysis / Q000276:immunology*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D011817:Rabbits / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014020:Tissue Extracts; D014316:Tritium
chemical_list: D000956:Antigens, Viral; D003470:Culture Media; D000939:Epitopes; D006023:Glycoproteins; D007106:Immune Sera; D037102:Lectins; D009363:Neoplasm Proteins; D014020:Tissue Extracts; D014316:Tritium