Improvement of pancreatic cancer model by modified treatment with N-nitroso-bis (2-oxopropyl) amine.
Comparative studies were conducted in 2 groups of Syrian golden hamsters treated with N-nitroso-bis (2-oxopropyl)amine (BOP) weekly for life (group A) or weekly for 6 weeks (group B), and sacrificed at 2-week intervals. Pancreatic neoplasms developed as early as 8 weeks (group B) and 10 weeks (group A); however, in group B there were fewer, smaller lesions, well-differentiated morphologically. Liver neoplasms occurred only in group A, while gallbladder and kidney tumors were seen in both groups. A lower incidence of pulmonary adenomas was found in group B than in group A, which also had pulmonary carcinomas. The results indicate a further advance in the development of a pancreatic cancer model.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D002278:Carcinoma in Situ / Q000139:chemically induced; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine