Aminoglycoside antibiotics and sympathetic ganglionic transmission.
The effects of streptomycin, gentamicin, tobramycin and amikacin on transmission in sympathetic ganglia have been studied using the guinea pig isolated hypogastric nerve-vas deferens preparation. These aminoglycoside antibiotics produce dose-related sympathetic blockade at concentrations greater than the common therapeutically effective antibiotic concentrations.
D000617:Aminoglycosides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000502:physiology; D005730:Ganglionic Blockers; D006168:Guinea Pigs; D007001:Hypogastric Plexus / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009435:Synaptic Transmission / Q000187:drug effects*; D014649:Vas Deferens / Q000294:innervation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005730:Ganglionic Blockers