Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers.
A rabies vaccine, prepared in human diploid-cell culture, was given intradermally (i.d.) or intramuscularly (i.m.) to 35 volumteers who had not previously received prophylactic immunisation.  Rabies neutralising antibody titres rose sharply after the first dose, and 4 weeks after the second dose all titres were above 1/80 (1-7 i.u. per ml.).  Immunisation via the i.d. and i.m. routes was equally successful in terms of likely immune status, but the i.d. rate was associated with many more local sideeffects.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D002478:Cells, Cultured; D004361:Drug Tolerance; D006801:Humans; D007110:Immunity, Active; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D008875:Middle Aged; D009500:Neutralization Tests; D011818:Rabies / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000009:adverse effects; D011820:Rabies virus / Q000276:immunology*; D012713:Serum Sickness / Q000453:epidemiology; D013997:Time Factors
D000914:Antibodies, Viral; D011819:Rabies Vaccines