Cephazolin sodium in the management of complicated urinary tract infection.
Forty-three patients were treated with cephazolin sodium, a parenteral cephalosporin antibiotic for 45 episodes of urinary tract infection complicated by a variety of underlying conditions. In 42 episodes, there was a satisfactory clinical response, and in 37 episodes this was associated with elimination of the bacterial pathogen from the urine. In 21 out of 31 patients available for examination 3 months later, the urine was still free of bacteria. A relatively prolonged plasma half-life and high urinary concentrations of the drug permit successful treatment of urinary tract infections with injections given only twice daily.
D000368:Aged; D001437:Bacteriuria / Q000188:drug therapy; D002437:Cefazolin / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications; D001745:Urinary Bladder Diseases / Q000150:complications; D001749:Urinary Bladder Neoplasms / Q000150:complications; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology; D014556:Urine / Q000382:microbiology
D002511:Cephalosporins; D002437:Cefazolin