Canine Gaucher disease--the enzymic defect.
beta-Glucosidase activity was investigated in tissues from a case of canine Gaucher disease and from a normal dog. In the latter, enzyme activity showed two pH optima at pH 4-0-4-25 and pH 5-0-5-5. In Gaucher disease tissues, negligible activity could be measured at the mouse acidic pH.
D000818:Animals; D001921:Brain / Q000201:enzymology; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs; D005776:Gaucher Disease / Q000201:enzymology / Q000662:veterinary*; D005959:Glucosidases / Q000378:metabolism*; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology; D013656:Taurocholic Acid / Q000494:pharmacology; D001617:beta-Glucosidase / Q000097:blood / Q000378:metabolism*
D013656:Taurocholic Acid; D005959:Glucosidases; D001617:beta-Glucosidase