Clinical and immunological studies of timothy antigen D immunotherapy.
The response to preseasonal immunotherapy with aqueous grass extract, timothy antigen D, or water-soluble timothy (WST) in alginate was compared in patients sensitive to grass pollen. Injections of antigen D in alginate produced little evidence of clinical or immunologic response. Treatment with aqueous grass extract or WST in alginate, on the other hand, significantly reduced the seasonal rise in grass-specific IgE. Aqueous extract therapy was also associated with a decline in leukocyte sensitivity during the pollen season, while WST treatment produced the greatest rise in hemagglutinating antibodies.
D000464:Alginates / Q000627:therapeutic use; D000941:Antigens; D006386:Hemagglutination Tests; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007167:Immunotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D006109:Poaceae / Q000276:immunology*; D011863:Radioimmunoassay; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D012882:Skin Tests
D000464:Alginates; D000941:Antigens; D010936:Plant Extracts; D007073:Immunoglobulin E