Enzymatic modification of the transplant antigens (ABO system) on human tumor cells.
Blood group glycosyltransferases were used to modify HeLa cells of H specificity (O Group) into cells of A and B specificity. We also obtained the identical type of modification with lymphocytes from healthy subjects and leukemia patients. This method can be applied to tumor cells in general, and constitutes an attempt to stimulate the immunocompetent system.
D000017:ABO Blood-Group System; D000939:Epitopes; D005696:Galactosidases / Q000494:pharmacology; D006367:HeLa Cells / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007938:Leukemia / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D005644:alpha-L-Fucosidase / Q000494:pharmacology
D000017:ABO Blood-Group System; D000939:Epitopes; D005696:Galactosidases; D005644:alpha-L-Fucosidase