[Characteristics of the interaction of Klebsiella rhinoscleromatis DNA with the sera from patient with systemic lupus erythematos].
In blood sera of patients with systemic red lupus there were observed antibodies, which interacted in reaction of indirect hemagglutination and in complement fixation test with DNA of scleromic bacteria and did not react with the other structures of bacterial cell: with Buaven antigen, detergent and capsular polysaccharides. Reaction of indirect hemagglutination of scleromic DNA with the sera was inhibited by DNA preparations of animal origin. The serological activity of DNA from scleromic bacteria depended upon its secondary structure and did not correlate with polymeric state and nucleotide composition of the biopolymer.
D000907:Antibodies, Bacterial / Q000032:analysis; D000937:Antigen-Antibody Reactions; D002845:Chromatography; D003168:Complement Fixation Tests; D004269:DNA, Bacterial / Q000276:immunology*; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D007106:Immune Sera; D007709:Klebsiella / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008970:Molecular Weight; D009691:Nucleic Acid Denaturation; D011135:Polysaccharides, Bacterial / Q000276:immunology; D013329:Structure-Activity Relationship
D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D000939:Epitopes; D007106:Immune Sera; D011135:Polysaccharides, Bacterial
Osobennosti vzaimodeĭstviia DNK Klebsiella rhinoscleromatis s syvorotkami bol'nykh sistemnoĭ krasnoĭ volchankoĭ