Re-evaluation of the antimineralocorticoid effect of the spironolactone metabolite, canrenone, from plasma concentrations determined by a new high-pressure liquid-chromatographic method.
D000328:Adult; D000818:Animals; D002191:Canrenoic Acid / Q000097:blood; D002192:Canrenone / Q000097:blood / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005438:Fludrocortisone / Q000494:pharmacology; D006801:Humans; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists; D011188:Potassium / Q000652:urine; D011245:Pregnadienes / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D013045:Species Specificity; D013148:Spironolactone / Q000494:pharmacology
D000451:Mineralocorticoid Receptor Antagonists; D011245:Pregnadienes; D013148:Spironolactone; D002192:Canrenone; D002191:Canrenoic Acid; D012964:Sodium; D011188:Potassium; D005438:Fludrocortisone