title: HL-A system and diabetes mellitus.
abstract: HL-A antigens were determined in 100 patients with diabetes mellitus. When the data are combined with that from other studies, there is a definite positive association of acute-onset juvenile diabetes mellitus with HL-A8 and W15. Four families are described in which two or more members with this type of diabetes are present, and in each family, affected individuals share a haplotype including HL-A8 or W15. These findings are consistent with the possible role of immune response genes in the HL-A chromosomal region which might control the immune response to virus infections capable of producing islet cell damage.
mesh_terms: D002446:Celiac Disease; D003601:Cytotoxicity Tests, Immunologic; D003920:Diabetes Mellitus / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D000939:Epitopes; D005796:Genes; D005838:Genotype; D006649:Histocompatibility Antigens; D006801:Humans; D007515:Islets of Langerhans; D010182:Pancreatic Diseases; D011236:Prediabetic State / Q000276:immunology; D014780:Viruses
chemical_list: D000939:Epitopes; D006649:Histocompatibility Antigens