title: [Therapeutic effect of a pharmacologic combination of choleretics and digestive enzymes in exocrine pancreatic insufficiency].
abstract: Phosphorylcholine and homocysteine have an important choleretic action and also potentiate exocrine pancreatic secretion by way of stimulation and a more effective preparation of the substrate against attack by lipolytic enzymes. The protection offered by pancreatic enzymes in the correction of the digestive insufficiency in the endoluminal stage is also known. An analysis was therefore made of the action of an association of phosphorylcholine homocysteine and digestive enzymes in cases of exocrine pancreatic insufficiency and primary or secondary malabsorption. This action was evaluated on the basis of the reduction of elimination of steatorrhoea. For this purpose, faecal lipids were determined with the method proposed by van de Kramer et al. The most significant results were obtained in cases where digestive insufficiency was most marked, where correction of the pancreatic enzyme deficiency and improved biliary function were particularly required.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000681:Amylases / Q000627:therapeutic use*; D002446:Celiac Disease / Q000188:drug therapy; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D002794:Choline / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000188:drug therapy; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy; D006710:Homocysteine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D010195:Pancreatitis / Q000188:drug therapy*; D011402:Pronase / Q000627:therapeutic use*; D012826:Silicone Elastomers / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000627:therapeutic use; D008061:Whipple Disease / Q000188:drug therapy
chemical_list: D002756:Cholagogues and Choleretics; D004338:Drug Combinations; D012826:Silicone Elastomers; D006710:Homocysteine; D000681:Amylases; D011402:Pronase; D002794:Choline; D014805:Vitamin B 12
vernacular_title: Sull'effetto terapeutico di una associazione farmacologica a base di coleretici ed enzimi digestivi nell'insufficienza pancreatica esocrina