Prednisone effect on microvascular permeability in patients with inflammatory rheumatic diseases.
The transcapillary escape rate of albumin was measured in 27 consecutive patients with inflammatory rheumatic diseases before and after 1 and 7 days of prednisone treatment in doses of 45 mg/day. The transcapillary escape rate decreased from 7.33%/h (range 5.11-9.55) before prednisone treatment to 3.11%/h (0.04-6.18) (p less than 0.05) after 1 day of treatment and 5.80%/h (4.36-7.24) after 7 days of treatment. It is concluded that prednisone inhibits vascular permeability in patients with inflammatory rheumatic diseases.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000503:physiopathology; D002199:Capillary Permeability / Q000187:drug effects*; D003882:Dermatomyositis / Q000188:drug therapy / Q000503:physiopathology; D013700:Giant Cell Arteritis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000503:physiopathology; D011111:Polymyalgia Rheumatica / Q000188:drug therapy / Q000503:physiopathology; D011241:Prednisone / Q000627:therapeutic use*; D012216:Rheumatic Diseases / Q000188:drug therapy / Q000503:physiopathology*; D012507:Sarcoidosis / Q000188:drug therapy / Q000503:physiopathology; D012711:Serum Albumin, Radio-Iodinated
D012711:Serum Albumin, Radio-Iodinated; D011241:Prednisone