Serological analysis of the HL--A10 complex.
In a Caucasian blood donor population largely of Polish and German origin, W25 and W26 were shown to be distinct antigens which comprise the entire specificity of HL--A10. These antigens were in linkage disequilibrium with W18 and W16 respectively. Multiparous women with antibody against HL--A10 (W25 -- W26) had husbands typing for either W25 or W26, but never both. Other sera against HL--A11 and W32 had extra antigen reactivity with W26 and W25 respectively. Serological analysis of 21 sera with W25 and W26 reactivity suggested that the broad HL--A10 complex comprises HL--A11--W26--W25--W32. The immunolgenicity and serological reactivity of the antigens in this complex may be explained with a concept of two paired amino acid substitutions at the antigenic determinant in the HL--A peptide chain.
D000939:Epitopes; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D007106:Immune Sera; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010298:Parity; D044465:White People
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007106:Immune Sera