Demonstration of 3-methoxytyrosine in the urine of melanoma patients.
With the aid of gas chromatography and mass spectrometry a metabolite of dopa, 3-methoxytyrosine, has been demonstrated in the urine of 2 patients with melanoma metastases, the amounts excreted being 4.0 mg and 8.5 mg/24 hours, respectively. 3-Methoxytyrosine could not with certainty be identified in the urines of two normal subjects.
D002849:Chromatography, Gas; D004295:Dihydroxyphenylalanine / Q000652:urine; D004298:Dopamine / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008545:Melanoma / Q000652:urine*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000652:urine*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000652:urine
D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D004298:Dopamine