Ontogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity-1,2.
Neonatal liver or adult spleen was used as a source of B-lymphocytes in reconstituting lethally irradiated, syngeneic mice. Recipients were all given excess adult, syngeneic thymus cells and were immunized with dinitrophenylated bovine gamma globulin. The distribution of avidities of plaque-forming cells produced by immunized recipients of neonatal liver was highly restricted in comparison with animals reconstituted with adult spleen indicating a restriction of B-lymphocyte heterogeneity in the neonatal mouse.
D000818:Animals; D000831:Animals, Newborn; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D000939:Epitopes; D006241:Haptens; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D008099:Liver / Q000276:immunology; D051379:Mice; D009578:Nitrobenzenes / Q000276:immunology; D011828:Radiation Chimera; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous; D005719:gamma-Globulins
D000939:Epitopes; D006241:Haptens; D009578:Nitrobenzenes; D005719:gamma-Globulins