Formalin infiltration of the ductus arteriosus. A method for palliation of infants with selected congenital cardiac lesions.
To circumvent the decreased pulmonary blood flow associated with closure of the ductus arteriosus in newborns with heart defects, we infiltrated buffered formalin solution into the wall of that structure to delay its closure. In four infants with pulmonary atresia in whom shunts had been unsuccessful or were technically not feasible, this procedure produced rapid improvement of arterial oxygen tension that was maintained in three infants for one to nine months. The other died of complications of attempted shunt procedures. In an infant with interrupted aortic arch and a large ventricular septal defect, formalin infiltration of the ductus and pulmonary arterial banding alleviated cardiac failure and improved lower-body perfusion. Formalin infiltration of the ductus is an effective palliative technic for treating certain congenital cardiac defects. No adverse effects have been noted.
D001011:Aorta / Q000002:abnormalities; D004373:Ductus Arteriosus / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D005557:Formaldehyde / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006330:Heart Defects, Congenital / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007267:Injections; D008297:Male; D008722:Methods; D010100:Oxygen / Q000097:blood; D010166:Palliative Care; D011651:Pulmonary Artery / Q000002:abnormalities / Q000601:surgery; D011652:Pulmonary Circulation; D011664:Pulmonary Valve / Q000601:surgery
D005557:Formaldehyde; D010100:Oxygen