Urinary excretion of 5-S-cysteinyldopa in patients with primary melanoma or melanoma metastasis.
Urinary excretion of 5-S-cysteinyldopa was studied in 9 patients with primary melanoma. All had 5-S-cysteinyldopa excretion in the normal range. In 8 of the patients excretion values decreased after removal of the tumour. Twenty-four patients with clinical signs of melanoma metastasis were examined for 5-S-cysteinyldopa and dopa+dopamine in the urine. 16 of the 24 had pathologically increased excretion of 5-S-cysteinyldopa and 7 of the 24 had pathological excretion of dopa+dopamine. Six of the latter belonged to the group with increased 5-S-cysteinyldopa excretion and one patient had a borderline value of 5-S-cysteinyldopa. Determination of 5-S-cysteinyldopa seems to be of value in the follow-up of patients operated on for primary melanoma.
D000328:Adult; D000368:Aged; D004295:Dihydroxyphenylalanine / Q000032:analysis / Q000652:urine*; D004298:Dopamine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000652:urine*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000652:urine*
D004295:Dihydroxyphenylalanine; D004298:Dopamine