title: Medical manipulation of the ductus arteriosus.
abstract: Prostaglandin E-1 was infused into two children with cyanotic congenital heart-disease where patency of the ductus arteriosus was necessary to maintain arterial oxygen  saturation. With each infusion oxygen saturation rose, probably as a result of dilatation of the ductus. Administration of the non-specific antagonist of prostaglandin synthesis, indomethacin, to one patient was associated with a fall in arterial saturation. The prevention of ductus closure by p.g.E-1 infusions over the first few weeks of life is a possiblility.
mesh_terms: D001794:Blood Pressure; D004373:Ductus Arteriosus / Q000187:drug effects*; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D010100:Oxygen / Q000097:blood; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000008:administration & dosage / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use*; D011674:Pulse; D013997:Time Factors
chemical_list: D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D010100:Oxygen; D007213:Indomethacin