title: Rapid screening for urease inhibitors.
abstract: Two methods are described that are suitable for the rapid screening of compounds as urease inhibitors. The first utilizes an electrode sensitive to NH4+ ions; the second is dependent on pH rise. A feature of both is a direct readout of reaction rate.
mesh_terms: D000086:Acetazolamide / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006877:Hydroxamic Acids / Q000378:metabolism / Q000652:urine; D011514:Proteus vulgaris / Q000201:enzymology; D011704:Pyelonephritis / Q000188:drug therapy / Q000382:microbiology / Q000652:urine; D014510:Urease / Q000037:antagonists & inhibitors* / Q000652:urine
chemical_list: D000900:Anti-Bacterial Agents; D006877:Hydroxamic Acids; D014510:Urease; D000086:Acetazolamide