Characterization of cytotoxic effector cells in the mouse mammary tumor system.
Cell types involved in the immune response in vitro to MTV-induced BALB/cfC3H mammary tumors have been studied with techniques designed to inactivate or deplete different cytotoxic effector cells from spleen cells populations. The minimal activity of spleen cells from neonatally MTV-infected virgin BALB/cfC3H females is dependent upon the presence of T cells. Spleens from multiparous BALB/cfC3H females bearing small tumors are similar to those of tumor-free multiparous females. However, after the tumors grow to large size, the activity of the non-T cell population is no longer detectable. The cytotoxic activity of spleen cells from BALB/c females older than 14 weeks (supposedly not infected with MTV) is not dependent upon the presence of T cells. No activity is shown by spleen cells from BALB/c females younger than 14 weeks. Positive control spleen cells were obtained from C3H female mice who had been immunized to BALB/c histocompatibility antigens by a skin allograft; both a T cell and a non-T cell response were found.
D000818:Animals; D000918:Antibody Specificity; D000951:Antigens, Neoplasm; D001666:Binding Sites, Antibody; D001921:Brain / Q000276:immunology; D002469:Cell Separation; D002470:Cell Survival; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007106:Immune Sera; D008214:Lymphocytes / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009757:Nylons; D011489:Protein Denaturation; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous; D005719:gamma-Globulins
D000951:Antigens, Neoplasm; D007106:Immune Sera; D009757:Nylons; D005719:gamma-Globulins; D003165:Complement System Proteins