[Long-term effect of calcium carbonate containing antacids on basally and peptone-stimulated hydrochloric acid secretion].
Basal and meal-stimulated gastric acid secretion was measured before and after a 3-week-period of regular consumption of a calcium carbonate-containing antacid with 6 therapeutic doses per day in normal healthy volunteers. Furthermore the effect of a single large dose of 2000 mg calcium ions was studied on meal-stimulated gastric acid secretion before and after this period. The results suggest that (1) even a large single dose of calcium ions seems to have no major effect on meal-stimulated gastric acid secretion and (2) chronic consumption of calcium carbonate containing antacids over a 3-week-period does not change basal- and meal-stimulated gastric acid secretion in healthy volunteers nor does it increase the response to 2 g calcium ions.
D000328:Adult; D000863:Antacids / Q000032:analysis*; D002118:Calcium / Q000097:blood; D002119:Calcium Carbonate / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010461:Peptones
D000863:Antacids; D010461:Peptones; D002119:Calcium Carbonate; D002118:Calcium
Langzeiteffekt Kalziumkarbonat-haltiger Antazida auf die basale und die Peptone-stimulierte Magensäure-Sekretion.