Effect of infusing selected chemical compounds on dentinal fluid movement in the rat.
Intra-arterial infusion of carbamyl phosphate or of carbamyl-DL-aspartic acid into rats on a cariogenic diet greatly stimulated the movement of fluid through the odontoblastic processes. The infusion of sodium cyanate also stimulated fluid movement. Guanidine HCL and L-asparagine were active at higher concentrations. Purifying the urea on a mixed-bed ion exchange resin virtually removed its stimulatory effect on dentinal fluid movement. The action of urea is apparently attributable to contamination with sodium cyanate.
D000167:Acriflavine / Q000378:metabolism; D000818:Animals; D001216:Asparagine / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002221:Carbamyl Phosphate / Q000494:pharmacology; D003485:Cyanates / Q000494:pharmacology*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D003804:Dentin / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004037:Diet, Cariogenic; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D009804:Odontoblasts / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012212:Rheology; D013194:Staining and Labeling; D014508:Urea / Q000494:pharmacology*
D002219:Carbamates; D003485:Cyanates; D006146:Guanidines; D000167:Acriflavine; D001224:Aspartic Acid; D002221:Carbamyl Phosphate; D001216:Asparagine; D014508:Urea