[Studies on the biotransformation of reproterol. Structure determination of the main metabolite (author's transl)].
Biotransformation of 7-(3-[2-(3,5-dihydroxyphenyl)-2-hydroxy-ethylamino]-propyl)-theophylline (reproterol, Bronchospasmin), a beta 2-adrenergic drug recently introduced into therapeutic use, leads to the same main metabolite in animals and in man. By mass-spectroscopy and by synthesis its structure was shown to be tetrahydroisoquinoline derivative which is produced from reproterol by uptake of an additional carbon atom concomitant with cyclization.
D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004586:Electrophoresis; D013058:Mass Spectrometry; D009921:Metaproterenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D051381:Rats; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D009921:Metaproterenol; D013806:Theophylline
Untersuchungen zur Biotransformation von Reproterol. Strukturaufklärung des Hauptmetaboliten.