The metabolism of lindance and its metabolites gamma-2,3,4,5,6-pentachlorocyclohexene, pentachlorobenzene, and pentachlorophenol in rats and the pathways of lindance metabolism.
The metabolism of lindane and its metabolites, gamma-PCCH, PCB, and PCP, has been studied in rats. Urine, faeces, blood and important organs were analyzed for free metabolities and those bound as beta-glucuronides. TeCCOL was identified as a main metabolite by GC/MS and gamma-PCCH has been evaluated toxicologically. A degradation scheme, based on experimental results and comprising only one hypothetical metabolite is proposed and discussed.
D000818:Animals; D001555:Benzene Derivatives / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002849:Chromatography, Gas; D003510:Cyclohexanes / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D001556:Hexachlorocyclohexane / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D010416:Pentachlorophenol / Q000378:metabolism*; D010636:Phenols / Q000378:metabolism*; D051381:Rats
D001555:Benzene Derivatives; D003510:Cyclohexanes; D010636:Phenols; D001556:Hexachlorocyclohexane; D010416:Pentachlorophenol