[Controlled therapeutic study of spontaneous bucco-linguo-facial dyskinesias (author's transl)].
A triple blind study has been conducted according to an original methodology to compare the effects of thioproperazine and tiapride on the spontaneous bucco-linguo-facial dyskinesias in the elderly. Side effects have been balanced to obtain a quantitative evaluation. Thioproperazine (3 x 3 mg/day) and tiapride (3 x 100 mg/day) reduce both significantly the number of dyskinesias, the former being more active than the latter. On the other hand, side effects of thioproprerazine are significantly higher than those of tiapride which are themselves not different from those induced by the placebo. Taking into account these results and the fact that dyskinesias represent a benign condition, the tiapride appears to be the first choice drug.
D000368:Aged; D001549:Benzamides / Q000627:therapeutic use*; D002610:Cheek; D002986:Clinical Trials as Topic; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000188:drug therapy*; D010640:Phenothiazines / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D013976:Tiapamil Hydrochloride / Q000009:adverse effects / Q000627:therapeutic use*; D014059:Tongue
D001549:Benzamides; D010640:Phenothiazines; D010919:Placebos; D013976:Tiapamil Hydrochloride
Etude thérapeutique contrôlée des dyskinésies bucco-linguo-faciales spontanées.