title: Antivibrionic activity of some glycolytic cycle enzymes of animal cells.
abstract: The antivibrionic activity of crystalline preparations of five enzymes of the glycolytic cycle of animals cells was investigated. Phosphorylase "a" (0.5 mg/ml), aldolase (15 mg/ml) and pyruvate kinase (0.1 mg/ml) were found to inhibit the proliferation of Vibrio cholerae cells; phosphoglucomutase and glyceraldehyde-3-phosphate dehydrogenase at a concentration of 0.25 mg/ml were found to be vibriocidal. A mixture of these enzymes containing 0.062 mg/ml of phosphorylase "a" and 0.125 mg/ml of each phosphoglucomutase, aldolase, glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase showed vibriocidal activity.
mesh_terms: D000900:Anti-Bacterial Agents; D005634:Fructose-Bisphosphate Aldolase / Q000494:pharmacology*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera / Q000494:pharmacology; D010733:Phosphoglucomutase / Q000494:pharmacology*; D010762:Phosphorylase a / Q000494:pharmacology*; D006005:Phosphorylases / Q000494:pharmacology*; D011770:Pyruvate Kinase / Q000494:pharmacology*; D014734:Vibrio cholerae / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D007106:Immune Sera; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010762:Phosphorylase a; D006005:Phosphorylases; D011770:Pyruvate Kinase; D005634:Fructose-Bisphosphate Aldolase; D010733:Phosphoglucomutase