Evaluation of cardiovascular and pulmonary changes during meperidine-diazepam anesthesia.
Studies were conducted in 189 oral surgery out-patients to evaluate the combination of meperidine hydrochloride and diazepam for anesthesia and to determine its effect on the cardiovascular and pulmonary systems. Results showed that neither ventricular cardiac arrhythmias nor clinically significant respiratory depression occurred in the sedated patients; meperidine-diazepam proved to be satisfactory for oral surgical procedures.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000766:Anesthesia, Dental; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000453:epidemiology; D001281:Atrial Fibrillation / Q000453:epidemiology; D001794:Blood Pressure / Q000187:drug effects*; D001919:Bradycardia / Q000453:epidemiology; D002245:Carbon Dioxide / Q000097:blood; D005117:Cardiac Complexes, Premature / Q000453:epidemiology; D002648:Child; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011674:Pulse / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects*; D013147:Spirometry; D013515:Surgery, Oral; D013610:Tachycardia / Q000453:epidemiology
D002245:Carbon Dioxide; D008614:Meperidine; D003975:Diazepam; D010100:Oxygen