Influence of beta-adrenoceptor blockade on leg blood flow and lactate release in man.
Nine healthy male volunteers were studied at rest and during exercise before and after acute local beta-blockade in one leg. Oxygen uptake, arterial pressure, heart rate, leg blood flow and arterial-femoral venous differences for oxygen and lactate were determined. In addition, five subjects were studied at rest during adrenaline infusion to test the blockade; in this situation the increase in leg blood flow and decrease in resistance seen in the control leg were prevented in the blocked leg. During exercise, the beta-blockade did not influence leg blood flow. At rest, lactate release was abolished from the blocked leg, and during exercise the release was reduced by 50%. These findings demonstrate that acute betareceptor blockade does not interfere with the exercise-induced vasadilation but has metabolic consequences reflected by a reduction in the release of lactate from the leg.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D007866:Leg / Q000098:blood supply*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology; D012146:Rest
D000319:Adrenergic beta-Antagonists; D007773:Lactates; D011433:Propranolol; D004837:Epinephrine