Effects of chronic administration of delta8- and delta9-tetrahydro-cannabinol on hepatic tyrosine aminotransferase activity in mice.
The effects of delta8-THC and delta9-THC administered twice weekly for 8 and 12 weeks at doses of 3, 10, and 30 mg/kg on murine hepatic tyrosine aminotransferase activity are described. These data suggest that treatment with relatively low doses of cannabinoids over long periods of time appear to produce some type of biochemical "tolerance," resulting in a diminished response, in contrast to previously reported data utilizing high doses of delta8-THC and delta9-THC over short experimental time periods.
D000818:Animals; D013759:Dronabinol / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000378:metabolism*
D013759:Dronabinol; D014444:Tyrosine Transaminase; D006854:Hydrocortisone