title: Occurrence of S-antigens in serum in Plasmodium falciparum infections in man.
abstract: Gambians with severe Plasmodium falciparum infections frequently have malarial S-antigens in their serum or plasma. Detection of these with the available antisera which are from immune adults is complicated because there are many different S-antigens and none of the antisera contains antibodies to them all. Despite this we found S-antigens in about 60% of a large series of malarious children and demonstrated that this was a considerable underestimate of the true incidence. We also showed that the prevalence of S-antigens was related to the malaria season and to the intensity of infection.
mesh_terms: D000941:Antigens / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D005714:Gambia; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007223:Infant; D008288:Malaria / Q000453:epidemiology / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D012995:Solubility
chemical_list: D000941:Antigens; D000939:Epitopes; D007106:Immune Sera