title: [Oxidation of fatty-aromatic aldehydes in liver tissues].
abstract: A protein fraction, which did not contain NADP [or NADPH]-dependent aldehyde reductase as well as NAD [or NADP]-dependent aldehyde dehydrogenases, but which catalyzed oxidation of fatty-aromatic aldehydes, was isolated from extract of rat liver tissue using ammonium sulfate fractionation combined with gradient syvorptive chromatography on DEAE-Sephadex A-25 [or Molselect DEAE-25], CM-Sephadex C-25 and gel-filtration on Sephadex G-200. Investigations of molecular weight and catalytic properties of the protein fraction obtained enabled to identify it with xanthine oxidase [EC 1.2.3.2]. Aldehyde dehydrogenases as well as xanthine oxidase are involved in oxidation of fatty-aromatic aldehydes to corresponding fatty acids, besides the reduction of the aldehydes to alcohols, catalyzed by aldehyde reductase and alcohol dehydrogenases.
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D004789:Enzyme Activation; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D014969:Xanthine Oxidase / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D000447:Aldehydes; D009243:NAD; D009249:NADP; D014969:Xanthine Oxidase; D000445:Aldehyde Oxidoreductases
vernacular_title: Ob okislenii zhirno-aromaticheskikh al'degidov v tkaniakh pecheni.