title: Metabolism of acebutolol-d6 in the rat correlates with the identification of a new metabolite in human urine.
abstract: The metabolism and excretion of acebutolol-d6, [1-(2-acetyl-4-n-butyramido-phenoxy)-2-hydroxy-3--[2H6]isopropylaminopropane] has been studied in the rat. Metabolites were characterized by thin-layer and gas chromatography, mass spectrometry, and the direct comparisons of metabolites to synthetic standards. Approximately 60% of the parent drug was excreted unchanged. Two major metabolites, an acetamide and an aniline, were identified in urine samples at relative concentrations of approximately 10% and 30%, respectively. The aniline analog of acebutolol was also identified in human urine.
mesh_terms: D000070:Acebutolol / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001711:Biotransformation; D006801:Humans; D008297:Male; D051381:Rats; D013045:Species Specificity
chemical_list: D000070:Acebutolol