Catecholamine synthesizing enzymes in brain stem and hypothalamus during the development of renovascular hypertension.
The activities of tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) have been measured in brain stem and hypothalamic nuclei during the development of renovascular hypertension. TH activity fell at 72 h in the posterior hypothalamic and peri- and paraventricular nuclei of the hypothalamus, but had returned to control levels by 7 days. PNMT activity was raised in the nucleus of the solitary tract at 7 days and was also elevated in the nucleus of the solitary tract, parahypoglossal nucleus, locus coeruleus and cerebellar cortex at 4 weeks. No change in PNMT was noted in hypothalamus. It appears from these results that both central noradrenergic and adrenergic pathways are involved in the development of this model of experimental hypertension.
D000818:Animals; D001794:Blood Pressure; D001933:Brain Stem / Q000201:enzymology*; D002525:Cerebellar Cortex / Q000201:enzymology; D004837:Epinephrine / Q000096:biosynthesis; D006977:Hypertension, Renal / Q000201:enzymology*; D007031:Hypothalamus / Q000201:enzymology*; D008125:Locus Coeruleus / Q000201:enzymology; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis; D010286:Paraventricular Hypothalamic Nucleus / Q000201:enzymology; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism*; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D014446:Tyrosine 3-Monooxygenase; D010625:Phenylethanolamine N-Methyltransferase; D009638:Norepinephrine; D004837:Epinephrine