Biliary and pancreatic secretions in abdominal irradiation.
The biliary and pancreatic secretions have been determined in patients given pelvic or para-aortic irradiation, with a dose of 50 Gy in the former group and between 36 and 40 Gy in the latter. A test meal containing polyethylene glycol (PEG) as reference substance was used. Each sample of the duodenal content was assayed for volume, PEG content, amylase and trypsin activity, pH and biliary secretion. No significant modifications of biliary and pancreatic secretions were demonstrated after irradiation, suggesting that these functions are not involved in the pathogenesis of the malabsorption radiation syndrome.
D000368:Aged; D000681:Amylases / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D004386:Duodenum; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000528:radiation effects; D007419:Intestinal Secretions / Q000032:analysis; D007422:Intestines / Q000528:radiation effects*; D008286:Malabsorption Syndromes / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010189:Pancreatic Juice / Q000378:metabolism*; D011092:Polyethylene Glycols; D011832:Radiation Injuries; D012636:Secretory Rate / Q000528:radiation effects; D013736:Testicular Neoplasms / Q000532:radiotherapy*; D014357:Trypsin / Q000378:metabolism; D014594:Uterine Neoplasms / Q000532:radiotherapy*
D011092:Polyethylene Glycols; D000681:Amylases; D014357:Trypsin