Hepatocellar hyalin (Mallory bodies) in long term griseofulvin-treated mice: a new experimental model for the study of hyalin formation.
Experimental studies on the significance and origin of hepatocellular "alcoholic" hyalin (Mallory bodies) are hampered by the lack of a suitable animal model. In the present paper, the experimental production of hepatocellular hyalin identical with human alcoholic hyalin both light and electron microscopically in long term griseofulvin-treated mice is described. Moreover, the results conclusively disprove the specificity of Mallory alcoholic hyalin for alcohol-induced liver cell damage.
D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D004195:Disease Models, Animal; D006118:Griseofulvin; D006801:Humans; D006818:Hyalin / Q000648:ultrastructure*; D008099:Liver / Q000648:ultrastructure*; D008106:Liver Cirrhosis, Experimental / Q000473:pathology*; D051379:Mice; D008854:Microscopy, Electron; D011164:Porphyrias / Q000139:chemically induced; D013997:Time Factors
D006118:Griseofulvin