[Use of aerosils in activating plasma prekallikrein].
Activation of prekallikreine from human blood plasma was studied using silica (airsiles), which carried functional groups with acidic and alkaline properties on the surface. Prekallikrein was similarly activated by amino- and carboxyairsiles, possessing positive and negative electric charges, respectively, at neutral pH value in a medium. Lysozyme, ribonuclease and spermidine inhibited partially the prekallikreine activation; spermine inhibited it completely.
D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000097:blood / Q000502:physiology*; D011288:Prekallikrein / Q000502:physiology*; D012822:Silicon Dioxide / Q000494:pharmacology*; D013499:Surface Properties; D013696:Temperature
D012822:Silicon Dioxide; D011288:Prekallikrein; D007610:Kallikreins
Primenenie aérosilov pri aktivatsii prekallikreina plazmy krovi.