The relationship between HLA antibodies and the causal pregnancy in choriocarcinoma.
By studying the HLA system, evidence of immunization by paternal antigens inherited by the antecedent child has been obtained in primiparous patients who subsequently developed choriocarcinoma. The same approach has been used to show which pregnancy was likely to be casual in two patients with complicated obstetric histories.
D002822:Choriocarcinoma / Q000235:genetics / Q000276:immunology*; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006238:Haploidy; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D008233:Lymphotoxin-alpha; D008297:Male; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D014594:Uterine Neoplasms / Q000235:genetics / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D008233:Lymphotoxin-alpha