title: Immunologic cross-reactivity of antigen(s) induced by drug treatment in two leukemic sublines.
abstract: Previous studies have demonstrated that new antigenic specificities, not detectable on parental cells, can be induced by in vivo treatment of murine leukemic cells with anti-neoplastic agents. The immunologic properties of leukemic cells altered by treatment with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC) were investigated further. Immunologic cross-reactivity between two DIC-treated leukemic sublines has been demonstrated by cell-mediated immunity in vitro and by active or adoptive immunity in vivo. Rabbit antiserum to DIC-treated sublines absorbed with the parental cells showed residual activity against the DIC-sublines that was specifically inhibited by further absorption with DIC-cells.
mesh_terms: D000818:Animals; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D003606:Dacarbazine; D000939:Epitopes; D007165:Immunosuppression Therapy; D007939:Leukemia L1210 / Q000139:chemically induced / Q000276:immunology*; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011817:Rabbits; D011828:Radiation Chimera; D014226:Triazenes
chemical_list: D000939:Epitopes; D014226:Triazenes; D003606:Dacarbazine