Non-competitive nature of the antagonistic mechanism responsible for tolerance development to opiate-induced analgesia.
D000698:Analgesia; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive; D001923:Brain Chemistry / Q000187:drug effects; D004343:Drug Implants; D004361:Drug Tolerance; D004558:Electric Stimulation; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D014828:Vocalization, Animal / Q000187:drug effects
D000701:Analgesics, Opioid; D004343:Drug Implants; D009020:Morphine