Inhibitory effect of guanfacine, a central alpha-adrenoceptor agonist, on prolactin secretion stimulated by insulin-induced hypoglycemia.
In six normal male volunteers oral administration of an alpha-receptor agonist, guanfacine (1 mg/q.i.d. for 4 days), had no effect on PRL release induced by 5 mg metoclopramide iv. The same treatment with quanfacine in six other normal subjects significantly reduced PRL secretion stimulated by insulin-induced hypoglycemia (P less than 0.05). These results suggest that an adrenergic pathway, hypothalamic or extrahypothalamic, might be involved in the inhibitory control of PRL secretion.
D000316:Adrenergic alpha-Agonists; D000328:Adult; D016316:Guanfacine; D006146:Guanidines; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007328:Insulin; D007700:Kinetics; D008297:Male; D008787:Metoclopramide; D010648:Phenylacetates; D011388:Prolactin / Q000378:metabolism*
D000316:Adrenergic alpha-Agonists; D006146:Guanidines; D007328:Insulin; D010648:Phenylacetates; D016316:Guanfacine; D011388:Prolactin; D008787:Metoclopramide