Local graft versus host reaction in the xenogeneic system.
The injection of viable rat spleen cells beneath the renal capsule of cyclophosphamide (CY)-treated adult mice produced a localized graft versus host reaction (GvHR), manifested by the kidney enlargement index (KI). The optimal xenogeneic GvHR was obtained after injection of 30-50 million rat spleen cells into mouse recipients treated 24 hr before with CY, 200 mg/kg intraperitoneally (i.p.), and killed 7 days later. Splenomegaly in recipient mice suggested systemic dissemination of the local GvHR.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D006087:Graft vs Host Reaction / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D013154:Spleen / Q000637:transplantation*; D014183:Transplantation, Heterologous
D003520:Cyclophosphamide