The Schultz-Dale reaction of the guinea-pig ileum: influence by beta-adrenoceptor agonists and theophylline.
One of the organs that can be used to study the Schultz-Dale reaction, is the guinea-pig ileum. The reaction is characterized by a specific pattern: a quick contraction, followed by a quick relaxation and a second, more slow contraction. A description is given of this typical reaction. Selective inhibition of the slow contraction could be obtained using beta-adrenoceptor agonists. Also theophylline inhibited the slow contraction, but this inhibition was only selective within a narrow range of concentration. These findings encourage further investigation about a possible involvement of cyclic nucleotides in the liberation of the mediators involved in the Schultz-Dale reaction of the guinea-pig ileum. Furthermore they provide more information about this preparation which could be used as a screening model for anti-allergic drugs of distinct pharmacological groups.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005280:Fenoterol / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010047:Ovalbumin; D013726:Terbutaline / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D010047:Ovalbumin; D013806:Theophylline; D007545:Isoproterenol; D013726:Terbutaline; D000420:Albuterol