[Comparative study of the sedative and tranquilizing effect of phenazepama and seduxen and their influence on human evoked brain potentials].
Phenazepam was compared to diazepam in a double-blind study made in 32 patients. The drugs were administered by month in doses of 0.0025 mg/kg and 0.005 mg/kg. respectively 1--2 days before surgery with the use of general anesthesia. Anxiety assessed by means of the brain evoked potential test and by a clinical test according to Gologorsky's scale reduced 2 hours following both phenazepam and diazepam administration. Phenazepam elicited a more pronounced and more lasting tranquilizing effect as compared to that of diazepam. Phenazepam was concluded to be a powerful anxiolytic and sedative agent recommended for premedication before surgical interventions.
D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D006993:Hypnotics and Sedatives; D010919:Placebos; D001569:Benzodiazepines; C017928:phenazepam; D003975:Diazepam
Sravnitel'noe ozuchenie sedativno-trankviliziruiushchego éffekta fenazepama i seduksena i ikh vliianie na vyzvannye potentsialy mozga u cheloveka.