[Can blockade of presynaptic adrenergic beta receptors explain the antihypertensive effects of propranolol?].
Pretreatment with 6-hydroxydopamine abolished the antihypertensive effects of intravenously and intracisternally administered dl-propranolol in dogs with acute neurogenic hypertension. These results show that the anti-hypertensive action of this drug is dependant on the integrity of central catecholaminergic neurones and suggest an action on presynaptic bêta-adrenoceptors.
D000319:Adrenergic beta-Antagonists / Q000037:antagonists & inhibitors*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000502:physiology; D004285:Dogs; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D009474:Neurons / Q000187:drug effects; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D006892:Hydroxydopamines; D011433:Propranolol
Le blocage des récepteurs présynaptiques bêta-adrénergiques peut-il expliquer les effets antihypertenseurs du propranolol?