title: Control of pulmonary ventilation during exercise and mediators in the blood: CO2 and hydrogen ion.
abstract: In reviewing the blood borne "mediators" to ventilation during exercise, our emphasis is on VCO2 and [H+]. We consider that exercise ventilation is more closely linked to VCO2 than to VO2. Lactic acid has a dual effect on ventilation, as it results in an increased CO2 output as well as increased [H+], an independent ventilatory stimulus. Examples from acid-base disturbances hypoxia and training are used to illustrate the relationship of VE to VCO2 and [H+].
mesh_terms: D000818:Animals; D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood*; D002395:Catecholamines / Q000378:metabolism; D004285:Dogs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000096:biosynthesis / Q000097:blood*; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism*; D010806:Physical Education and Training; D005082:Physical Exertion; D010809:Physical Fitness; D012119:Respiration
chemical_list: D002395:Catecholamines; D007773:Lactates; D002245:Carbon Dioxide