Correlation of the blood-level of a pregnancy-associated alpha-macroglobulin with the clinical course of cancer patients.
The variations in serum level of a pregnancy-associated alpha-macroglobulin (P.A.M.) were studied during the treatment of breast-cancer patients. Good correlation was found between P.A.M. concentrations and the course of the disease--levels rose prior to the clinical recognition of metastatic disease and decreased significantly on successful treatment. Periodic P.A.M. determinations may allow detection of tumour recurrence while it is still at a treatable stage.
D000510:Alpha-Globulins / Q000032:analysis*; D001943:Breast Neoplasms / Q000097:blood* / Q000150:complications / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008259:Macroglobulins / Q000032:analysis*; D008408:Mastectomy; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications
D000510:Alpha-Globulins; D008259:Macroglobulins