Action of anti-mouse IgE on mouse and rat mast cells.
The action of anti-mouse IgE on normal or sensitized mouse and rat peritoneal mast cells as well as on the reaginic activity of mouse and rat antisera was studied. Anti-mouse IgE induced histamine release from normal mouse peritoneal mast cells in vitro and this effect was greatly enhanced when mast cells were actively sensitized. The action of anti-mouse IgE on normal rat peritoneal mast cells was slight; it was enhanced after sensitization of these cells with mouse reaginic antibodies as well as after active sensitization. Moreover, anti-mouse IgE is able to neutralise the reaginic activity of mouse and rat antisera. The results suggest that there exist some functional and structural similarities between mouse and rat IgE.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D005260:Female; D006636:Histamine Release; D007106:Immune Sera; D007114:Immunization; D007073:Immunoglobulin E; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D010047:Ovalbumin / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats
D000888:Antibodies, Anti-Idiotypic; D007106:Immune Sera; D007073:Immunoglobulin E; D010047:Ovalbumin