Breast cancer, prostaglandins, and bone metastases.
Human malignant breast tumours from 23 patients contained and synthesised more prostaglandin-like material than normal breast tissue from the same patients or benign neoplasms (5 patients). Bone metastases were associated with tumours having high levels of P.G.-like material, which usually resembled P.G.F compounds, and this may be important since some P.G.S are potent bone-resorbing substances.
D000328:Adult; D000368:Aged; D001681:Biological Assay; D001859:Bone Neoplasms / Q000209:etiology*; D001862:Bone Resorption / Q000187:drug effects; D001943:Breast Neoplasms / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011453:Prostaglandins / Q000032:analysis / Q000096:biosynthesis*
D011453:Prostaglandins