Induction of hypersensitivity to carboxymethylcellulose in cattle.
Cattle were more readily sensitised than guinea pigs to carboxymethylcellulose. Freund's complete adjuvant enhanced, but was not essential for, sensitisation. Schultz-Dale responses were obtained from pulmonary tissues of sensitised cattle but their sera failed to induce passive cutaneous anaphylaxis. Cattle could possibly be sensitised by carboxymethylcellulose contained in drug formulations.
D000707:Anaphylaxis / Q000276:immunology / Q000662:veterinary; D000818:Animals; D000941:Antigens / Q000032:analysis; D001886:Bordetella pertussis / Q000276:immunology; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000276:immunology / Q000662:veterinary*; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006168:Guinea Pigs; D006636:Histamine Release; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008747:Methylcellulose / Q000031:analogs & derivatives*; D009119:Muscle Contraction; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis
D000941:Antigens; D008747:Methylcellulose; D010047:Ovalbumin; D005620:Freund's Adjuvant; D002266:Carboxymethylcellulose Sodium