Does secretin influence rat colonic absorption and secretion?
In rats, a secretin (Jorpes) intravenous infusion superimposed on an intracolonic sodium acetate perfusion elicits, with respect to control values, a significant depression of Na+ absorption (0.16 mEq./h-0.00 mEq./h.) and mucus secretion (230-40 mg.). When the hormone is superimposed upon an intracolonic infusion of acetic acid, mucus secretion is also significantly inhibited (790-340 mg.). The influence of secretin on organic anion movement was pH related. At pH values of 7.0, absorption was unchanged (0.34--0.33 mEq./h.), at pH values of 2.9, absorption was significantly reduced (0.67-0.41 mEq./h). The secretin impairment of colonic mucus secretion could influence the transport of watersoluble (Na+) and lipid soluble (acetic acid) substances, probably through changes at the "unstirred layer" level.
D000085:Acetates; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009093:Mucus / Q000378:metabolism*; D051381:Rats; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D012964:Sodium / Q000378:metabolism
D000085:Acetates; D012633:Secretin; D012964:Sodium