[Lithium modifications of the cataleptogenic properties of various neuroleptic drugs in the rat].
After unique ip injection (11,78 mEq/kg) LiCl increases in the Rat catalepsy produced by chlorpromazine, prochlorperazine, fluphenazine, levomepromazine, haloperidol and reserpine. This phenomenon is more important according to cataleptigenic properties of neuroleptic drugs. After repeated injections of LiCl (5 mEq/kg/d/5 dip) potentiation of catalepsy is more fugacious and not produced by levomepromazine and reserpine. LiCl would interfere at enzymatic level with dopaminergic transmission either by inhibiting activity of cerebral adenylcyclase (unique injection) or by inhibiting dopamine synthesis (repeated injections).
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced*; D004357:Drug Synergism; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D010640:Phenothiazines; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D014150:Antipsychotic Agents; D010640:Phenothiazines; D012110:Reserpine; D008094:Lithium; D006220:Haloperidol
Modifications par le lithium des propriétés cataleptigènes de quelques neuroleptiques chez le rat.