Enkephalin-dopamine interactions in behavioral arousal.
1. Central injection of a long lasting enkephalin analog (D-Ala2-leu-enkephalin-amide) produced a syndrome of stereotyped motor activity. 2. This activation syndrome was significantly reduced by two dopamine (DA) blockers (pimozide, fluspririlene) and by an agonist of inhibition-mediating DA receptors [(3,4-dihydroxyphenylamino)-2-imidazoline]. 3. Intact DA functioning is necessary for the occurrence of this enkephalin-mediated behavioral syndrome.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002395:Catecholamines / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D004745:Enkephalins / Q000494:pharmacology*; D005484:Fluspirilene / Q000494:pharmacology; D048288:Imidazolines; D008297:Male; D051379:Mice; D010868:Pimozide / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects
D002395:Catecholamines; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D004745:Enkephalins; D048288:Imidazolines; D011954:Receptors, Dopamine; D010868:Pimozide; D005484:Fluspirilene; C011775:(3,4-dihydroxyphenylamino)-2-imidazoline