[Hemodynamics after prindolol and digitalis in acute myocardial infarction (author's transl)].
In 20 patients with acute myocardial infarction hemodynamic controls were performed after digitalisation and following i.v. injection of 0,4 mg of Prindolol. Circulatory changes were most pronounced 5-15 min after Prindolol injection and consisted of decrease in heart rate of 7%, mean arterial blood pressure of 6%, cardiac output of 10,5%, stroke volume index of 5,1% and left ventricular work of 18%. An increase of pulmonary wedge pressure of 17%, pulmonary pressure of 9%, mean right atrial pressure of 16% and peripheral arterial resistance of 6% were calculated. In 5 cases a favourable effect on extrasystoles and in 2 cases on sinus tachycardia were observed. Not infrequently, during the initial phase of acute myocardial infarction, a hyperadrenergic state may be noted. Prindolol may be indicated, when circulatory changes or arrhythmias are suspect to be the result of this hyperadrenergic stimulation. A simultaneous digitalisation may inhibit a more intensive cardiodepression.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D002302:Cardiac Output / Q000187:drug effects; D004071:Digitalis Glycosides / Q000008:administration & dosage*; D004077:Digoxin / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D010869:Pindolol / Q000008:administration & dosage* / Q000627:therapeutic use; D011651:Pulmonary Artery / Q000503:physiopathology; D012770:Shock, Cardiogenic / Q000188:drug therapy; D013610:Tachycardia / Q000188:drug therapy; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D004071:Digitalis Glycosides; D004077:Digoxin; D010869:Pindolol
Hämodynamische Reaktionen nach Prindolol und Digitalis bei akutem Herzinfarkt