Inhibition of adrenal function in man by heparin or heparinoid Ro 1-8307.
Heparin and the heparinoid Ro 1-8307 inhibited the secretory rate of aldosterone in physiological or pathological aldosteronism to the level found in normal subjects on liberal sodium intake. In addition, these compounds inhibited corticosterone biosynthesis, although less markedly than that of aldosterone. Indications of interference with cortisol production have not been found. During drug treatment angiotensin, in doses of 5-10 ng/kg b.wt./min, did not stimulate aldosterone secretion. ACTH responsiveness of the adrenals--indicated by the fractional increases of both aldosterone and corticosterone secretory rates--remained unchanged. In two studies heparin had no consistent effect on plasma renin activity.
D015062:11-Hydroxycorticosteroids / Q000652:urine; D015065:17-Hydroxycorticosteroids / Q000652:urine; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003345:Corticosterone / Q000378:metabolism; D003864:Depression, Chemical; D006493:Heparin / Q000494:pharmacology* / Q000627:therapeutic use; D006496:Heparinoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy / Q000378:metabolism; D011865:Radioisotope Dilution Technique; D012083:Renin / Q000097:blood; D012636:Secretory Rate / Q000187:drug effects*; D012964:Sodium / Q000652:urine; D013268:Stimulation, Chemical; D014316:Tritium
D015062:11-Hydroxycorticosteroids; D015065:17-Hydroxycorticosteroids; D006496:Heparinoids; D014316:Tritium; D000804:Angiotensin II; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D006493:Heparin; D012964:Sodium; D012083:Renin; D003345:Corticosterone