Acute myelocytic leukaemia and leukaemia-associated antigens in sisters.
In a sibship of 5 brothers and 7 sisters, 3 sisters died from acute myelocytic leukaemia while a 4th probably had the same disease. Laboratory studies on the close relatives revealed that a 5th sister had persistently high erythrocyte sedimentation-rates and serum-IgM levels and serological evidence of acute leukaemia-associated antigens. These findings suggest a possible preleukaemic state in this patient.
D000208:Acute Disease; D000328:Adult; D000951:Antigens, Neoplasm / Q000302:isolation & purification*; D002986:Clinical Trials as Topic; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006680:HLA Antigens / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006650:Histocompatibility Testing; D006801:Humans; D007075:Immunoglobulin M / Q000302:isolation & purification; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics* / Q000276:immunology; D008297:Male; D010375:Pedigree; D012737:Sex Factors
D000951:Antigens, Neoplasm; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007075:Immunoglobulin M