title: Conventional immunoglobulin therapy.
abstract: Concentrated gamma globulin as a substitute for deficient B-cell function is usually given by the intramuscular route. The intravenous administration would be preferable, but presents major difficulties, mainly with shock-life reactions. Most of them are due to rapid activation of the complement system by aggregated IgG. The attempts to avoid such reactions include exposure of gamma globulin concentrates to pepsin, plasmin, low pH, beta-propiolactone, polymers, salts and millipore filtration. The results improved slowly, but they are still not entirely satisfactory.
mesh_terms: D000042:Absorption; D000361:Agammaglobulinemia / Q000628:therapy; D000917:Antibody Formation; D000918:Antibody Specificity; D001986:Bronchial Spasm / Q000209:etiology; D011232:Chemical Precipitation; D003165:Complement System Proteins / Q000378:metabolism; D004406:Dysgammaglobulinemia / Q000628:therapy; D005341:Fibrinolysin; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000209:etiology; D007141:Immunoglobulin Fc Fragments; D007167:Immunotherapy; D007275:Injections, Intravenous / Q000009:adverse effects; D008851:Micropore Filters; D010434:Pepsin A; D011108:Polymers; D011420:Propiolactone; D005719:gamma-Globulins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007141:Immunoglobulin Fc Fragments; D011108:Polymers; D005719:gamma-Globulins; D011420:Propiolactone; D003165:Complement System Proteins; D005341:Fibrinolysin; D010434:Pepsin A