title: Reduction of menstrual blood-loss by prostaglandin-synthetase inhibitors.
abstract: Six patients with menorrhagia due to dysfunctional uterine bleeding and one patient with an intrauterine contraceptive device were treated with prostaglandin-synthetase inhibitors in an attempt to reduce their excessive menstrual blood-loss. Mefenamic acid (six patients) or flufenamic acid (one patient) taken during menstruation for 2-3 cycles reduced menstrual loss in each patient. These preliminary observations suggest a new treatment for a common gynaecological problem and could imply that prostaglandins are involved in the aetiology of excessive menstrual blood-loss in such patients.
mesh_terms: D000328:Adult; D001800:Blood Specimen Collection / Q000379:methods; D016861:Cyclooxygenase Inhibitors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects; D008528:Mefenamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008595:Menorrhagia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D013997:Time Factors
chemical_list: D016861:Cyclooxygenase Inhibitors; D008528:Mefenamic Acid; D006899:Mixed Function Oxygenases