Werner's syndrome and malignancy.
Ten per cent of all patients with Werner's syndrome develop some form of malignant disease, half of them sarcomas. A case of Werner's syndrome is reported in which the patient had a malignant fibroxanthoma of the thigh followed by a papillary cystadenocarcinoma of the ovaries. A brother with clinical signs of Werner's syndrome died of acute leukaemia.
D000328:Adult; D003537:Cystadenoma / Q000209:etiology*; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology*; D011230:Precancerous Conditions; D012878:Skin Neoplasms / Q000209:etiology*; D014898:Werner Syndrome / Q000150:complications*