[Glucose-6-phosphate transformation in the tissues of animals which have received high doses of hydroxythiamine or thiamine].
Administration of hydroxythiamin or thiamin into rats at a dose 400 mg/kg body weight caused a single-directed (unspecific, nonenzymatic) effect on the activity of glucose-6-phosphate and 6-phosphogluconate dehydrogenases within short periods (3-12 hrs). Within 24 and 72 hrs the effects of vitamin and antivitamin acquired the opposite (specific) direction towards the activity of glucose-6-phosphate dehydrogenase in liver tissues. Content of glucose-6-phosphate was altered depending on time of hydroxythiamin effect. Reverse correlation between the activity of glucose-6-phosphate dehydrogenase and content of the substrate was observed in heart muscle either after administration of hydroxythiamin or thiamin; the phenomenon suggest that dehydrogenase reactions affect considerably the regulation of glucose-6-phosphate content in the tissue.
D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000032:analysis / Q000201:enzymology; D009206:Myocardium / Q000032:analysis / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010119:Oxythiamine / Q000494:pharmacology*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D013831:Thiamine / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D005958:Glucosephosphates; D013844:Thiazoles; D009243:NAD; D010119:Oxythiamine; D009249:NADP; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013831:Thiamine
Prevrashcheniia gliukozo-6-fosfata v tkaniakh zhivotnykh poluchaiushchikh vysokie dozy oksitiamina ili tiamina.