[The effect of D-penicillamine on experimental allergic arthritis in rabbits].
The effect of D-penicillamine on experimental allergic arthritis in rabbits (16 with arthritis and 15 controls) was investigated. After 40 days of treatment with D-penicillamine (intravenous) the arthritis had receded to a large extent. At the same time a maturation inhibition of the hematopoietic marrow had occurred in all the treated arthritic and control animals. The results suggest that D-penicillamine affects fast proliferating cells, to which the precursors of immunologically active cells in the synovial membrane also belong.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D010396:Penicillamine / Q000494:pharmacology*; D011817:Rabbits; D013583:Synovial Membrane / Q000473:pathology; D005719:gamma-Globulins / Q000032:analysis
D005719:gamma-Globulins; D010396:Penicillamine
Zur Wirkung von D-Penicillamin auf die experimentelle allergische Arthritis des Kaninchens