Low molecular weight specific proteins in identified molluscan neurons. II. Processing, turnover, and transport.
Three identified neurons (R14, R15, and L2-6) from Aplysia californica synthesize specific, low molecular weight proteins which are further processed or converted into smaller sized specific proteins. These specific proteins have differential turnover rates, and appear to be selectively transported out of the individual neuronal somata at different rates. The latter transport process can be blocked by colchicine, a well-known blocker of axonal transport. The relationship of these phenomena to the functional activity of the individual neurons is discussed.
D000818:Animals; D001370:Axonal Transport; D003078:Colchicine / Q000494:pharmacology; D005724:Ganglia / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008970:Molecular Weight; D008974:Mollusca / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D007930:Leucine; D003078:Colchicine