Synthesis and pharmacological activity of derivatives of exo-trimethylenenorbornane. I.
Lithium aluminum hydride reduction of exo-5,6-trimethylenenorbornan-2-one oxime gave in good yield exo-5,6-trimethylenenorbornan-2-endo-amine, from which a number of amides were prepared by reaction with acyl chlorides. Lithium aluminum hydride reduction of the above-mentioned amides afforded N-substituted exo-5,6-trimethylenenorbornan-2-endo-amines in good yields. Some amides showed CNS depressant and anti convulsant activity, and an amine convulsant activity in mice.
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis; D014150:Antipsychotic Agents / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D001892:Camphanes / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D014150:Antipsychotic Agents; D001892:Camphanes; D012110:Reserpine; D000661:Amphetamine