title: [Histone-heparin complexes].
abstract: Histones form insoluble complexes with heparin and neutralize its anticoagulant action. The plasmin degradation products of histones do not possess these properties. Plasmin also digests histones in complexes with heparin. Breakdown of the histones in these complexes causes release of heparin from them.
mesh_terms: D000818:Animals; D002417:Cattle; D003029:Coagulants; D004336:Drug Antagonism; D005341:Fibrinolysin / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D006494:Heparin Antagonists; D006657:Histones / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D010783:Photometry; D012965:Sodium Chloride / Q000494:pharmacology; D013535:Suspensions; D013918:Thrombin Time; D013949:Thymus Extracts / Q000494:pharmacology*; D014508:Urea / Q000494:pharmacology
chemical_list: D003029:Coagulants; D006494:Heparin Antagonists; D006657:Histones; D013535:Suspensions; D013949:Thymus Extracts; D012965:Sodium Chloride; D014508:Urea; D006493:Heparin; D005341:Fibrinolysin
vernacular_title: Kompleksy histonów z heparyna.