title: Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells.
abstract: A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome.  Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term culture. Cells taken from the tumors were nearly triploid, retained all human chromosome markers, and had the same antigenic determinants(s) as cells in culture.
mesh_terms: D000015:Abnormalities, Multiple / Q000276:immunology*; D000818:Animals; D002875:Chromosomes; D002999:Clone Cells; D000939:Epitopes; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics / Q000276:immunology*; D008251:Macaca; D051379:Mice; D009368:Neoplasm Transplantation; D011003:Ploidies; D013154:Spleen / Q000002:abnormalities*; D013950:Thymus Gland / Q000002:abnormalities*
chemical_list: D000939:Epitopes