[Red cell metabolism and function in shock (author's transl)].
In patients with shock the metabolism and O2-function of the erythrocytes were studied following separation according to cell-age by density layer centrifugation using a new supporting medium. Metabolic acidosis in patients with postoperative shock (n=8) and in patients with shock due to severe congestive heart failure (n=12) provoked decreased levels of 2,3-diphosphoglycerate, ADP, ATP and reduced glutathione. Raised lactate/pyruvate ratios were observed also in both groups, whereas the O2-function of the erythrocytes was markedly disturbed in all patients. Patients of both groups received glucocorticoid-infusions resulting in a significant improvement of the extent and pattern of the red cell metabolic disorder.
D000328:Adult; D001692:Biological Transport; D004163:Diphosphoglyceric Acids / Q000097:blood; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010101:Oxygen Consumption; D010313:Partial Pressure; D012773:Shock, Surgical / Q000097:blood*
D004163:Diphosphoglyceric Acids; D008775:Methylprednisolone
Erythrozytenstoffwechsel und -funktion im Schock.