Blood-group precursors and cancer-related antigens.
Glycoprotein extracts from colonic tumours were tested for blood-group precursor-like activities using human anti-I and anti-i cold agglutinins as reagents. Substantial activity was detected in the high-molecular-weight fractions of two metastatic tumours. A carcinoembryonic antigen (C.E.A.) fraction from one of these tumours was also active. The C.E.A. and the precursor-like activities were located on separate molecules. These data indicate that the levels of precursor-like antigens in entodermal tumours and their possible diagnostic value warrant detailed investigation.
D000951:Antigens, Neoplasm; D001789:Blood Group Antigens; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002850:Chromatography, Gel; D003110:Colonic Neoplasms / Q000276:immunology*; D000939:Epitopes; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007048:I Blood-Group System; D008113:Liver Neoplasms / Q000276:immunology; D008970:Molecular Weight; D009362:Neoplasm Metastasis; D011233:Precipitin Tests
D000951:Antigens, Neoplasm; D001789:Blood Group Antigens; D002272:Carcinoembryonic Antigen; D000939:Epitopes; D006023:Glycoproteins; D007048:I Blood-Group System