Cordycepin inhibition of 3-methylcholanthrene-induced transformation in vitro.
Cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, was found to inhibit the induction of the endogenous type "C" RNA virus by 5-iodo-2'-deoxyuridine in a line of Fisher rat embryo cells (H43) grown in vitro, and when continuously incorporated into the medium at those same concentrations, it was found to protect the cells from transformation by the chemical carcinogen 3-methylcholanthrene.
D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003839:Deoxyadenosines / Q000494:pharmacology* / Q000633:toxicity; D007065:Idoxuridine / Q000037:antagonists & inhibitors; D008748:Methylcholanthrene / Q000037:antagonists & inhibitors*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012190:Retroviridae / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development
D003839:Deoxyadenosines; D008748:Methylcholanthrene; D012194:RNA-Directed DNA Polymerase; D007065:Idoxuridine