title: Chromosome abnormalities in Dupuytren's disease.
abstract: Palmar fascia from six men with Dupuytren's contracture has been grown in tissue-culture and examined cytogenetically; and in three of these cases skin was also studied. Four of the six cases showed mosaicism, but only in cultures of the fascia; the mosaicism was therefore unlikely to be an artefact. Since the abnormalities were inconsistent and absent from skin-cultures they are very unlikely to indicate any mechanism of inheritance. Similar chromosome abnormalities have been reported from experimentally induced tumours.
mesh_terms: D002460:Cell Line; D002869:Chromosome Aberrations; D002999:Clone Cells; D046508:Culture Techniques; D004387:Dupuytren Contracture / Q000235:genetics* / Q000473:pathology; D005205:Fascia / Q000473:pathology; D006225:Hand; D006801:Humans; D007621:Karyotyping; D008297:Male; D008938:Mitosis; D012730:Sex Chromosomes; D012867:Skin / Q000473:pathology