Uptake of taurine, GABA, 5-HT, and dopamine by blood platelets in progressive myoclonus epilepsy.
The uptakes of four neurotransmitters (taurine, GABA, 5-HT, and dopamine) by blood platelets from patients with degenerative-type progressive myoclonus epilepsy (PME) and from controls were studied using different incubation times and different concentrations. Only the uptakes of taurine differed significantly between patients and controls: patients' uptakes were 70% to 80% of control values at 10, 30, 60, and 120 min of incubation time. Km values were approximately the same, but Vmax values in PME patients were lower, showing quantitative but not qualitative differences in taurine uptake by platelets in PME. These results suggest that a defect or an inhibitory mechanism of some factor needed in the transport or binding of taurine (but not of GABA, 5-HT, and dopamine) is present in PME.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004298:Dopamine / Q000097:blood; D004831:Epilepsies, Myoclonic / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood*; D012701:Serotonin / Q000097:blood; D013654:Taurine / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000097:blood
D018377:Neurotransmitter Agents; D013654:Taurine; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine