Study of the metabolic effects of bunitrolol (Koe 1366) in angina induced by catecholamine infusion.
In ten angina patients responding with a myocardial anaerobic metabolic pattern to isoproterenol infusion, a new beta-blocking agent, bunitrolol, was effective in normalizing the myocardial lactate extraction ratio. The correlation with lipid metabolism was also interesting because beta-blocker action reduced significantly arterial non-esterified fatty acids (NEFA) level as well as myocardial NEFA extraction. The metabolic behavior suggests the effectiveness of bunitrolol in the treatment of ischemic heart disease.
D000787:Angina Pectoris / Q000139:chemically induced / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011412:Propanolamines / Q000494:pharmacology*; D011773:Pyruvates / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011412:Propanolamines; D011773:Pyruvates; D007545:Isoproterenol