The effect of antigen suicide on numbers of cells binding defined antigenic determinants.
Lymph node cells from guinea pigs immunized to oxidized ferredoxin (O-Fd) were treated in an antigen suicide procedure designed to inactivate lymphocytes binding the haptenic peptide determinants of the ferredoxin molecule. O-Fd-induced DNA synthesis and cells binding either peptide determinant were examined both before and after allowing suicide. The proliferative response to O-Fd and the number of determinant-binding cells were specifically and markedly decreased after antigen suicide.
D000818:Animals; D000941:Antigens; D001665:Binding Sites; D000939:Epitopes; D005288:Ferredoxins / Q000378:metabolism; D006168:Guinea Pigs; D007457:Iodine Radioisotopes; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male
D000941:Antigens; D000939:Epitopes; D005288:Ferredoxins; D007457:Iodine Radioisotopes