Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum.
Deaggregatedhuman gamma-globulin (DHGG) injected into female mice within 24 hr after delivery of a litter enters the colostrum and is absorbed intact through the intestine by nursing neonates. This absorbed HGG was present in the neonatal circulation at concentrations of 0.3 to 0.6 mg/ml of serum under the experimental conditions used. This absorption of HGG by the nursing neonate resulted in a complete, specific, tolerant state to HGG. This tolerant state was stable upon adoptive cell transfer and could not be abrogated by transfer of normal syngeneic spleen cells.
D000042:Absorption; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D000939:Epitopes; D005260:Female; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D007116:Immunization, Passive; D051379:Mice; D008805:Mice, Inbred A; D005719:gamma-Globulins / Q000494:pharmacology*
D000939:Epitopes; D005719:gamma-Globulins