[Induction, by 5-bromo-2'-deoxyuridine, of a "foamy" virus previously undetected in hamster cells transformed by SV40].
TSV5 clone 2 cells in normal conditions of culture contain only an expressed RNA virus (R-type virus). However, exposure of the cells to 5-bromo-2'-deoxyuridine with dexamethasone, induced synthesis of a syncitium-forming ("Foamy") virus. In other hamster cell lines, the same treatment fails to induce a "foamy" virus. The origin of this "foamy" virus is discussed.
D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D008854:Microscopy, Electron; D012328:RNA Viruses / Q000254:growth & development*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013539:Simian virus 40; D016092:Spumavirus / Q000201:enzymology / Q000254:growth & development*; D014779:Virus Replication / Q000187:drug effects*
D012194:RNA-Directed DNA Polymerase; D001973:Bromodeoxyuridine
Induction, par la 5-bromo-2'-désoxyuridine, d'un virus de type "foamy" inapparent dans des cellules de hamster transformées par le SV 40