Polarographic behaviour of 2-(5-nitro-2-furyl)-5-(2-aminoethoxy)- pyrimidine derivatives.
Polarographic reduction of the title compounds in mixtures of Britton-Robinson buffers and methanol (1:1) or DMF (3:1) for compound 10 at the pH range of 2.8--11.3 is described. In strongly acid medium the compounds were reduced in two diffusion governed waves corresponding to the consecutive reduction of NO2-group (6-electron wave) and pyrimidine ring (2-electron wave) to amine and dihydropyrimidine, respectively; with increasing pH the second wave became, however, much worse shaped. In alkaline medium a third wave appeared, the limiting current of which corresponded to a 2-electron process; the wave corresponds probably to the further reduction of pyrimidine ring to tetrahydroderivative. Mechanism of the reduction of the title compounds  has been suggested and discussed.
D055598:Chemical Phenomena; D002621:Chemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D008628:Mercury; D011048:Polarography; D011743:Pyrimidines / Q000032:analysis*
D011743:Pyrimidines; D008628:Mercury