[Induction of ion transport coupled to oxidative reactions in the membranes of mitochondria and liposomes].
The mechanism of induction of potassium permeability for mitochondrial membranes under special conditions was under study. Conditions were such as: 1--incubation of mitochondria in medium with low meaning of pH (6,0--6,5), 2--incubation in preseace of electrophylic agent--p-(N,N-di-2-chloroethyl) aminophenylacetic acid, which is hydrolized to HCl and 3-lipidsoluble acid, 2,4-dinitrophenol. It is shown that the named mechanism in any case requires the oxidation of lipids of mitochondrial membranes.
D000693:Anaerobiosis; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004140:Dinitrophenols / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008081:Liposomes; D008563:Membrane Lipids; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D010648:Phenylacetates / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D051381:Rats
D004140:Dinitrophenols; D008081:Liposomes; D008563:Membrane Lipids; D009588:Nitrogen Mustard Compounds; D010648:Phenylacetates; D004492:Edetic Acid; D011188:Potassium
Induktsiia ionnogo transporta, sopriazhennaia s okislitel'nymi reaktsiiami v membranakh mitokhondriĭ i liposom.