Combination chemotherapy of Rauscher leukemia and ascites tumors by narcissus alkaloid with standard drugs and effect on cellular immunity.
The therapeutic activity of the narcissus residual alkaloid A-2 against Rauscher leukemia has been compared with 10 standard anticancer drugs, and synergistic or additive combination pairs have been selected using a viral leukemia and two transplantable tumor systems. An increased beneficial effect has been demonstrated by a combination of the alkylating and DNA-binding agents and the alkaloid against the three malignant tumors, while a beneficial effect by combining the alkaloid and the antimetabolites (either 6-MP or 5-azacytidine) was seen only against the viral leukemia. The alkaloid has no suppressive activity against cellular immunity as tested by PHA reactivity and allogeneic tumor rejection systems.
D000470:Alkaloids / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001374:Azacitidine / Q000008:administration & dosage; D001773:Blood Cells; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002330:Carmustine / Q000008:administration & dosage; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004640:Emetine / Q000008:administration & dosage; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal; D011925:Rauscher Virus; D013154:Spleen; D013308:Streptonigrin / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D000470:Alkaloids; D000970:Antineoplastic Agents; D003609:Dactinomycin; D013308:Streptonigrin; D014750:Vincristine; D003520:Cyclophosphamide; D001374:Azacitidine; D002330:Carmustine; D004640:Emetine; D008727:Methotrexate; D003630:Daunorubicin