Inhibition of glucose-6-phosphate dehydrogenase activity by scorpion Leiurus quinquestriatus (H and E) venom.
Crystalline glucose-6-phosphate dehydrogenase was significantly inhibited by L-quinquestriatus venom. Neither boiling nor dialysis could abolish this inhibition completely. Raising the concentration of either G6P or NADP in the reaction mixture reversed the inhibition, indicating that the latter was competitive with respect to the substrate and the coenzyme.
D000818:Animals; D001667:Binding, Competitive; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D006358:Hot Temperature; D008297:Male; D009249:NADP; D012604:Scorpion Venoms / Q000494:pharmacology*; D012605:Scorpions
D012604:Scorpion Venoms; D009249:NADP; D005954:Glucosephosphate Dehydrogenase