title: [Malignant syndrome caused by neuroleptics (3 observations)].
abstract: This study concerns 3 cases of malignant syndrome due to neuroleptics. Our aim is to clarify the nature of this syndrome and to attempt to delimit it from malignant hyperthermia. The etiology suggests that its occurence should increase with the growing use of very active neuroleptics. It consists clinically of an extrapyramidal syndrome with hypertonicity, akinesia, tremor and with a neuro-vegetative syndrome of which the main sign is hyperthermia. On the basis of physiopathology it is attempted to explain, in the light of fresh data, the extrapyramidal signs, the hyperthermia and the rise in the OPK Etiological treatment has, however, proved disappointing.
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000506:poisoning*; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005476:Fluphenazine / Q000506:poisoning; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D010395:Penfluridol / Q000506:poisoning; D010640:Phenothiazines / Q000506:poisoning; D011954:Receptors, Dopamine / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D010640:Phenothiazines; D011954:Receptors, Dopamine; D010395:Penfluridol; D003402:Creatine Kinase; D005476:Fluphenazine
vernacular_title: Le syndrome malin aux neuroleptiques (à propos de trois observations).