title: [Enzymatic fibrinolytic agents].
abstract: Urokinase (UK) and streptokinase (SK) transform plasminogen into plasmin by rupture of a ARG-VAL bond and the liberation of a peptide with a molecular weight of 6000 to 8000. Urokinase is a physiological activator with a direct action. By contrast, streptokinase is an enzyme of bacterial origin and two hypotheses may be advanced to explain its mechanism of action: the formation of a SK-plasminogen complex capable of activatiing new molecules of plasminogen or the formation of a SK-plasminogen complex within which plasminogen is transformed to plasmin.
mesh_terms: D010450:Endopeptidases / Q000502:physiology*; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis; D008970:Molecular Weight; D010958:Plasminogen / Q000378:metabolism; D010960:Plasminogen Activators / Q000502:physiology; D013300:Streptokinase / Q000502:physiology*; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology*
chemical_list: D010958:Plasminogen; D010450:Endopeptidases; D013300:Streptokinase; D010960:Plasminogen Activators; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Les agents fibrinolytiques enzymatiques.