title: Choline chloride in schizophrenia.
abstract: The authors investigated the possibility that choline chloride might reduce schizophrenic symptoms by increasing central cholinergic activity. In a single blind crossover study, up to 20 g/day of choline chloride had no significant effect on clinical ratings of nine schizophrenic patients. However, there was some evidence that choline significantly increased symptoms of depression.
mesh_terms: D000328:Adult; D010054:Brief Psychiatric Rating Scale; D002794:Choline / Q000009:adverse effects / Q000627:therapeutic use*; D003863:Depression / Q000139:chemically induced; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D010277:Parasympathomimetics; D002794:Choline