Genetic control of the immune response to the H-2 associated Slp alloantigen in the mouse.
A survey of sixteen standard inbred and congenic resistant strains of mice reveals that the ability to mount an immune response to the Slp allotype is associated with the H-2 type of the recipient. Strains carrying the H-2f, H-2k, and H-2q haplotypes are able to produce specific antibody whereas strains of the H-2b haplotype are non-responders. Analysis of F1-hybrids and four informative intra-H-2-recombinants demonstrates that the ability to respond to the Slp allotype is controlled by a dominant gene associated with the K end of the H-2 complex.
D000818:Animals; D000917:Antibody Formation; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003434:Crossing Over, Genetic; D000939:Epitopes; D005260:Female; D005799:Genes, Dominant; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007115:Immunization Schedule; D005779:Immunodiffusion; D007125:Immunogenetics; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D010641:Phenotype; D011995:Recombination, Genetic; D009626:Terminology as Topic
D000939:Epitopes; D006649:Histocompatibility Antigens; D007106:Immune Sera