[Liberation of histamine by anaesthetics (author's transl)].
Injection of Epontol (7 mg/kg i.v.) to male healthy students caused a brief increase in plasma histamine concentration from 0.7 ng/ml to 3.0 ng/ml. Combined injection (7 mg/kg) and infusion of Epontol (21 mg/kg during 15 min) or combined injection of Epontol (7 mg/kg) and suxamethonium (0.5 mg/kg) caused a more prolonged appearance of histamine in plasma without higher maximum concentrations. During anaesthesia with ketamine (Ketanest), halothane or nitrous oxide the histamine concentrations in plasma remained unaltered.
D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006221:Halothane; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007649:Ketamine; D008297:Male; D009609:Nitrous Oxide; D011410:Propanidid / Q000008:administration & dosage / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D013390:Succinylcholine / Q000494:pharmacology*
D004338:Drug Combinations; D007649:Ketamine; D006632:Histamine; D011410:Propanidid; D013390:Succinylcholine; D009609:Nitrous Oxide; D006221:Halothane
Histaminfreisetzung durch Narkosemittel