Anti-inflammatory drug actions on allergic responses in guinea-pig skin.
Five non-steroidal anti-inflammatory drugs (indomethacin, naproxen, meclofenamic acid, feprazone and phenylbutazone: NSAIDs) and three glucocorticosteroids (dexamethasone, hydrocortisone and prednisolone) have been tested as local inhibitors of increased vascular permeability in guinea-pig skin. Lesions were induced by histamine or by antigen to evoke type I (passive cutaneous anaphylaxis), type III (reverse passive Arthus) and type IV (delayed hypersensitivity) allergic reactions. NSAIDs and glucocorticosteroids caused either weak, inconsistent inhibition or slight, high-dose inhibition of the response to histamine. None of the drugs tested showed significant inhibition of the type IV response. The NSAIDs caused dose-related inhibition of both type I and type III responses whereas glucocorticosteroids were ineffective. Maximum inhibition with the NSAIDs was never greater than 50--60% Feprazone, meclofenamic acid and indomethacin were the most potent inhibitors of histamine, PCA and Arthus responses respectively. The possible significance of the effects of these anti-inflammatory agents on vascular permeability is discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001183:Arthus Reaction / Q000503:physiopathology; D012898:Autacoids / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D003872:Dermatitis / Q000503:physiopathology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006967:Hypersensitivity / Q000503:physiopathology*; D006968:Hypersensitivity, Delayed / Q000503:physiopathology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D012898:Autacoids; D006632:Histamine