title: Heterozygote advantage in cystic fibrosis: mosquito tests.
abstract: Tests to demonstrate a preference by mosquitoes for stinging controls as opposed to obligate heterozygotes for Cystic Fibrosis proved negative. If a heterozygote advantage caused a lower malarial incidence in carriers in South West Africa, it must have worked through the malarial parasite being adversely affected by a serum factor. This remains to be tested.
mesh_terms: D009033:Culicidae; D003550:Cystic Fibrosis / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007299:Insect Bites and Stings; D008288:Malaria / Q000453:epidemiology / Q000401:mortality