Action of bleomycin on the bacteriophate T7 infection.
A decrease in production of bacteriophage T7 was observed in bleomycin-treated Escherichia coli B cells. Bleomycin was found to shorten the eclipse in phage growth. A T7 early gene product, the T7-specific RNA polymerase which catalyzed the transcription of late gene appeared more rapidly in the bleomycin-treated cells than in the non-treated cells. The rate of phage adsorption increased to some extent in drug-treated cells. A possible mechanism to explain the mode of action of bleomycin is discussed.
D001761:Bleomycin / Q000494:pharmacology*; D003090:Coliphages / Q000187:drug effects*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism; D006150:Guanine Nucleotides / Q000378:metabolism
D006150:Guanine Nucleotides; D001761:Bleomycin; D012321:DNA-Directed RNA Polymerases