Induction of acid-stable canine interferon in vivo and in vitro.
Dogs were able to produce only small quantities of circulating interferon after intraperitonal injection of Newcastle disease virus or polyinosinic-polycytidylic acid. Similarly, canine cell cultures produced very low concentrations of interferon in response to Newcastle disease virus or polyinosinic-polycytidylic acid and no detectable concentrations of interferon in response to pyran copolymer or tilorone hydrochloride. The antiviral substance met the physiochemical characteristics classically associated with interferon.
D000818:Animals; D002478:Cells, Cultured; D004285:Dogs / Q000276:immunology*; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis*; D009522:Newcastle disease virus / Q000276:immunology; D011070:Poly I-C / Q000494:pharmacology; D013696:Temperature
D007372:Interferons; D011070:Poly I-C