Drug-induced agranulocytosis. A survey of twenty-three episodes.
Twenty-three episodes of drug-induced agranulocytosis admitted to the Beilinson Medical Center between 1960-1972 are reported. An increased incidence in patients admitted with this condition was noted over the years. Dipyrone (6 episodes in 4 patients) and chloramphenicol (5 episodes in 5 patients) were the drugs most commonly associated with this condition. Four patients died in septic shock. The increased incidence of hospital-admitted patients with drug-induced agranulocytosis is related to the increased use of drugs in the Israeli population.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D000632:Aminopyrine / Q000031:analogs & derivatives*; D000890:Anti-Infective Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D013956:Antithyroid Agents / Q000009:adverse effects; D002701:Chloramphenicol / Q000009:adverse effects*; D002747:Chlorpropamide / Q000009:adverse effects; D004177:Dipyrone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013956:Antithyroid Agents; D000632:Aminopyrine; D004177:Dipyrone; D002701:Chloramphenicol; D002747:Chlorpropamide