Lymphocytotoxins and immunologic unresponsiveness.
A 14-year-old boy with a lifelong history of recurrnet infections and debilitating bronchiectasis was found to lack any evidence of humoral or cellular immunity. His serum contained a high titer of IgM antibody to the heavy chain of IgG and this antibody was also cytotoxic for peripheral lymphocytes. Complement-dependent lymphocytotoxicity could be blocked by IgG or Fc fragment. In this patient, immunosuppression may have been due to an autoantibody against both autologous IgG and lymphocyte plasma membrane.
D000293:Adolescent; D000888:Antibodies, Anti-Idiotypic; D001987:Bronchiectasis / Q000276:immunology; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006386:Hemagglutination Tests; D006801:Humans; D007111:Immunity, Cellular; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007165:Immunosuppression Therapy; D037102:Lectins; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology; D008233:Lymphotoxin-alpha; D008259:Macroglobulins / Q000032:analysis; D008297:Male; D012882:Skin Tests; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D007075:Immunoglobulin M; D037102:Lectins; D008233:Lymphotoxin-alpha; D008259:Macroglobulins; D003165:Complement System Proteins