Differences in the susceptibility of mouse lines to the rickettsial pox agent.
A definite correlation between the susceptibility of spleen macrophage cultures derived from a highly susceptible mouse line (C57Bl/6) and a line with low susceptibility (DBA/2) and the susceptibility of these mouse lines to infection with Rickettsia acari was established. Intensive replication of the rickettsiae in cultures from highly susceptible animals caused marked disorders in cell metabolism and eventually death of the culture. Cell cultures derived from resistant mice gradually eliminated the rickettsiae by intracellular digestion; necrobiotic changes in them were insignificant.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D008264:Macrophages; D051379:Mice; D008815:Mice, Inbred Strains; D012281:Rickettsia / Q000254:growth & development*; D012288:Rickettsiaceae Infections / Q000382:microbiology*; D013154:Spleen