Integration of viral genomes.
DNA transcripts of infectious RNA viruses were found to be integrated in the DNA of chronically-infected tissue cultures.  DNA sequences homologous to RNA of measles virus were found in tissues affected with systemic lupus erythemotosus.  These data open up a new class of virus-cell interaction that may be a result of cooperation between infectious and oncogenic viruses.
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D004279:DNA, Viral / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000382:microbiology*; D008459:Measles virus / Q000276:immunology / Q000378:metabolism*; D009858:Oncogenic Viruses / Q000378:metabolism; D012328:RNA Viruses / Q000378:metabolism*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects
D004279:DNA, Viral; D003609:Dactinomycin; D012194:RNA-Directed DNA Polymerase