[Action of levorin on amino acid transport in Candida albicans].
It was shown that suppression by levorin of the leucine transport into the cells of C. albicans was due to replacement of intracellular K+ by Na+ induced by the antibiotic. The alanine transport was suppressed by levorin irrespective of the ratio of the monovalent cations concentration in the medium and inside the cell. The levorin effect on the protone escape from the cells was negligible and probably played no significant role in the mechanism of the amino acid transport suppression by the antibiotic.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000935:Antifungal Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002174:Candicidin / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D007930:Leucine / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011522:Protons
D000596:Amino Acids; D000935:Antifungal Agents; D003470:Culture Media; D011522:Protons; D002174:Candicidin; D007930:Leucine; D000409:Alanine; D011188:Potassium; D002118:Calcium
Deĭstvie levorina na transport aminokislot u Candida albicans.