Tumor growth inhibition by ammonium chloride-induced acidosis.
Ammonium chloride-induced metabolic acidosis decreases the growth of various experimental tumors. Spleen exhibits the same effects. There is a sex factor which seems to affect the growth of both tumor and spleen. The observed tumor inhibition appears to be related to a systemic impairment of the anabolic mechanisms. The decrease in tumor calcium suggests that this element may play a role in the tissue growth. The possible implication of cell membrane changes and of a block in glycolysis in the acidosis effects are discussed.
D000138:Acidosis / Q000139:chemically induced; D000230:Adenocarcinoma / Q000378:metabolism; D000643:Ammonium Chloride / Q000008:administration & dosage*; D000818:Animals; D001761:Bleomycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002136:Calcium, Dietary; D004273:DNA, Neoplasm / Q000378:metabolism; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007942:Leukemia, Experimental / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D012513:Sarcoma, Experimental / Q000378:metabolism; D012737:Sex Factors; D013154:Spleen / Q000254:growth & development / Q000378:metabolism
D002136:Calcium, Dietary; D004273:DNA, Neoplasm; D010743:Phospholipids; D012334:RNA, Neoplasm; D000643:Ammonium Chloride; D001761:Bleomycin; D010758:Phosphorus; D008274:Magnesium; D002118:Calcium