[Treatment of advanced neoplasms in the jaw].
Report is made about the combined therapy with cytostatics (methotrexate - bleomycin) and irradiation in patients with extended tumors in the gnathic region. Ten patients in whom a radical therapy with conventional methods did not promise any success, were treated with intra-arterial infusions of methotrexate and bleomycin and simultaneous irradiation. At present, eight patients are tumor free (observation time 4-14 months after termination of therapy). Although radiation doses and doses of cytostatics were high, only insignificant side effects were stated; consequently, the treatment had to be terminated in none of the patients.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002342:Carotid Artery, External; D002404:Catheterization / Q000009:adverse effects; D010478:Chemotherapy, Cancer, Regional Perfusion; D004487:Edema / Q000209:etiology; D005153:Facial Neoplasms / Q000628:therapy; D005354:Fibrosarcoma / Q000628:therapy; D006801:Humans; D007269:Injections, Intra-Arterial; D007573:Jaw Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D008545:Melanoma / Q000628:therapy; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010212:Papilloma / Q000628:therapy; D010610:Pharyngeal Neoplasms / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage
D000970:Antineoplastic Agents; D001761:Bleomycin; D008727:Methotrexate
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