title: Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness.
abstract: The beta effects of adrenergic stimulation are often diminished in asthmatics in whom the condition is active. Corticosteroids are thought to lower the threshold of beta-adrenergic receptors to the response of catecholamines. A single intravenous injection of 40 mg prednisolone appeared to restore responsiveness to inhaled isoprenaline in eight out of ten chronic asthmatics who were previously non-responsive to catecholamines.
mesh_terms: D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011239:Prednisolone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D011941:Receptors, Adrenergic / Q000187:drug effects*
chemical_list: D000336:Aerosols; D010919:Placebos; D011941:Receptors, Adrenergic; D011239:Prednisolone; D007545:Isoproterenol