Effect of generalized graft-versus-host-reaction on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.
The investigations of 400 adult hybrids from A/Jax fem. BALB/c male were aimed at answering the following questions: 1. What is the influence of a generalized graft-versus-host-reaction (GVHR) on the induction and growth of benzpyren-induced sarcoma? 2. What is the behavior of B- and T-lymphocytes during GVHR, and during induction and growth of benzpyren-induced sarcoma? 3. Which are the deductions to be drawn with regard to the effect of B- and T-lymphocytes during tumorigenesis and tumor growth?


RESULTS
1. The number of tumors was significantly greater in the GVHR animals (74.5%) than in the controls (49.5%). 2. A significant decrease of T-lymphocytes and increase of B-lymphocytes during GVHR were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a marked decrease of the total round cell count and the T cells, while the count of B-lymphocytes remained uninfluenced. These results are discussed and compared with results of other authors.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001580:Benzopyrenes; D002452:Cell Count; D005260:Female; D006087:Graft vs Host Reaction; D017710:Lymphocyte Transfusion; D051379:Mice; D012513:Sarcoma, Experimental / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D001580:Benzopyrenes