[Increase in myocardial resistance to ischemia by excluding the heart from the circulation by using a beta-adrenergic receptor block].
The effect of propranolol on the function of the heart, its hemodynamics and metabolism was studied on dogs and rats. It was established that propranolol-induced block of the beta-adrenergic receptors is conducive to a decrease in the intensity of myocardial metabolism and increase of myocardial tolerance to ischemia.
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Povyshenie ustoĭchivosti miokarda k ishemii pri vykliuchenii serdtsa iz krovoobrashcheniia s pomoshch'iu blokady beta-adrenergicheskikh retseptorov.