Do "anorectic" drugs produce weight loss by appetite suppression?
A peripheral action on glucose metabolism may play an improtant part in the weight loss associated with treatment with some antiobesity drugs such as fenfluramine and mazindol. In therapeutic concentrations these agents increase glucose uptake into animal and human skeletal muscle. This action is distinct from their effects on central transmitters and from the reduction in food intake in animals.
D000818:Animals; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants / Q000494:pharmacology* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009132:Muscles / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy; D051381:Rats
D001067:Appetite Depressants; D005947:Glucose