[On the respiration analeptic effect of fominoben HCl after administration of pethidine/promethazine (author's transl)].
The respiratory stimulatory effect of 3'chloro-2'-(N-methyl-N-[(morpholino-carbonyl)methyl]-aminomethyl)benzanilide hydrochloride (fominoben, Noleptan, PB 89) on the respiratory-depressing effect of pethidine/promethazine was investigated. In addition a double blind study was carried out on 36 patients with fominoben or placebo after pethidine/promethazine. To evaluate respiratory function the vital capacity, Tiffeneau-value, volume of inhaled air/s, maximum breathing capacity, as well as the blood gas values (pO2, pCO2 and pH according to Astrup) were measured. The results can be summarised as follows: 1. As was to be expected the combination pethidine/promethazine caused a deterioration in all parameters. This negative effect could be partially improved by fominoben. 2. A marked difference in the volume of inhaled air/s could be seen after fominoben in comparison to the placebo. The remaining differences were insignificant. 3. Pethidine/promethazine had, as had been expected, a significant effect on pain symptoms, but no analgetic effect could be shown for fominoben.
D001784:Blood Gas Analysis; D002245:Carbon Dioxide; D004347:Drug Interactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008614:Meperidine / Q000494:pharmacology*; D009025:Morpholines / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010919:Placebos; D011398:Promethazine / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D014797:Vital Capacity / Q000187:drug effects
D009025:Morpholines; D010919:Placebos; D002245:Carbon Dioxide; D008614:Meperidine; D011398:Promethazine
Uber die atemanaleptische Wirkung von Fominoben-HCl nach Pethidin/Promethazin-Gabe.