title: Prostaglandins and obesity.
abstract: In metabolic obesity energy in triglyceride stores is not readily accessible, and lipolysis to free fatty acid and glycerol seems to be somehow restrained. In the normal situation, there is a balance between a forward reaction via cyclic A.M.P. ending in lipolysis and a negative-feedback mechanism in which prostaglandins participate. In metabolic obesity there may be a biochemical error leading to overproduction of prostaglandins; as a result the forward reaction is overwhelmed and lipolysis does not take place. Since prostaglandin antagonists and inhibitors of prostaglandin synthesis are known, this hypothesis is not without therapeutic interest.
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D002395:Catecholamines / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005246:Feedback; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D009765:Obesity / Q000378:metabolism*; D010726:Phosphodiesterase Inhibitors; D011453:Prostaglandins / Q000096:biosynthesis* / Q000494:pharmacology / Q000502:physiology; D047428:Protein Kinase Inhibitors; D011941:Receptors, Adrenergic; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D010726:Phosphodiesterase Inhibitors; D011453:Prostaglandins; D047428:Protein Kinase Inhibitors; D011941:Receptors, Adrenergic; D014280:Triglycerides; D000324:Adrenocorticotropic Hormone; D005990:Glycerol