Inhibition by 5-hydroxytryptamine of anaphylactic histamine release from bovine granulocytes.
A suspension of granulocytes from calves sensitised to horse plasma released histamine when exposed to the antigen. Histamine release was strongly inhibited by 5-hydroxytryptamine in a dose-related fashion. 5-HT is known to be released from bovine lungs in vitro, and may regulate the release of histamine in vivo during anaphylaxis.
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D000941:Antigens; D002417:Cattle; D003864:Depression, Chemical; D006098:Granulocytes / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D006736:Horses / Q000276:immunology; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology*
D000941:Antigens; D012701:Serotonin