[Randomised study on histaminelike side-effects of 5 common plasmasubstitutes in orthopedic surgery (author's transl)].
Preceding anaesthesia 750 randomised patients, sub-divided into 5 different age groups, were given 500 ml of a standard plasma-substitute at a flow rate of 25-30 ml/min. There was direct correlation (p=0.1%) of the frequency of side-effects to the substance used; none, however, to the age or general surgical risk. Side-effects were observed in 21.3% with derivates of gelatin as compared to 3.7% with Macrodex and Plasmasteril combined. The rate of more serious anaphylactoid reactions was 6% with Haemaccel, 1.3% with Gelifundol-S, 0.67% with Macrodex and less than 0.67% with Neo-Plasmagel. The study reveals that serious side-effects may be expected in orthopaedictic patients after application of plasma substitutes. As a prophylactic procedure for those patients we recommend, therefore, the application of these substances only after careful consideration of the indications for their use.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000707:Anaphylaxis; D003876:Dermatitis, Atopic; D003911:Dextrans / Q000009:adverse effects; D004342:Drug Hypersensitivity; D006636:Histamine Release; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects; D006969:Hypersensitivity, Immediate; D008875:Middle Aged; D009985:Orthopedics; D010952:Plasma Substitutes / Q000009:adverse effects* / Q000494:pharmacology; D011097:Polygeline / Q000009:adverse effects; D011229:Preanesthetic Medication; D012119:Respiration / Q000187:drug effects
D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D011097:Polygeline
Pathergiequote verschiedener Plasmasubstitute an Haut und Respirationstrakt orthopädischer Patienten