Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileum.
Strains of Yersinia enterocolitica produce a heat-stable enterotoxin which is positive in the suckling mouse bioassay. Partial purification by a procedure previously worked out for heat-stable Escherichia coli enterotoxin yielded a substance which increases particulate guanylate cyclase activity and short-circuit current and inhibits active Cl-absorption in rabbit ileal mucosa. These effects of Y. enterocolitica enterotoxin are similar to those of heat-stable E. coli enterotoxin, suggesting a common mechanism of action.
D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004594:Electrophysiology; D004768:Enterotoxins / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000378:metabolism; D007082:Ileum / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D015007:Yersinia
D002712:Chlorides; D004768:Enterotoxins; D006162:Guanylate Cyclase; D006152:Cyclic GMP