title: Toleration of artificial tears - the effect of pH.
abstract: We studied the effect of altering the pH of an artificial tear preparation on the tolerance of 20 patients with keratoconjunctivitis sicca. Of those who expressed a preference, 11/17 preferred a tear substitute more alkaline than any preparation now available in North America. We recommend an alkaline tear substitute as a valuable alternative in patients with keratoconjunctivitis sicca.
mesh_terms: D000328:Adult; D000368:Aged; D001548:Benzalkonium Compounds / Q000008:administration & dosage; D001881:Borates / Q000008:administration & dosage; D001888:Boric Acids / Q000008:administration & dosage; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004339:Drug Compounding; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007637:Keratoconjunctivitis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011189:Potassium Chloride / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D001548:Benzalkonium Compounds; D001881:Borates; D001888:Boric Acids; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D012965:Sodium Chloride; D011189:Potassium Chloride; D008747:Methylcellulose