Chemical modification of crab nerves can make them insensitive to the local anaesthetics tetrodotoxin and saxitoxin.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000992:Antitoxins; D003386:Brachyura; D002234:Carbodiimides / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D005998:Glycine / Q000494:pharmacology; D008956:Models, Chemical; D008959:Models, Neurological; D009431:Neural Conduction / Q000187:drug effects*; D010539:Permeability; D012521:Sarcosine / Q000494:pharmacology; D012530:Saxitoxin / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology*
D000992:Antitoxins; D002234:Carbodiimides; D012530:Saxitoxin; D013779:Tetrodotoxin; D012964:Sodium; D005998:Glycine; D012521:Sarcosine