[Effect of palmitoyl-CoA binding with adenine nucleotide translocase on energization of mitochondria].
Under conditions of inhibiting oxidative phosphorylation of oligomycin palmitoyl-CoA (p-CoA) decreases the rate of energy dependent reduction of acetoacetate and Ca2+-capacity of mitochondria in a phosphate medium. Energy independent osmotic swelling of mitochondria in NH4NO3, which depends on H+ permeability of the inner mitochondrial membrane is inhibited by ADP and acclereated by p-CoA. Carnitin and competitive ADP abolish all the effects of p-CoA. It is concluded that decreased energization induced by p-CoA is related to an increase in the inner mitochondrial membrane permeability b- H+ as a result of the inhibitor bindings with adenine nucleotide translocase.
D000214:Acyl Coenzyme A / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002331:Carnitine / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D009713:Nucleotidyltransferases / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010171:Palmitoyl Coenzyme A / Q000494:pharmacology*; D051381:Rats
D000214:Acyl Coenzyme A; D009840:Oligomycins; D010171:Palmitoyl Coenzyme A; D000244:Adenosine Diphosphate; D000226:Mitochondrial ADP, ATP Translocases; D009713:Nucleotidyltransferases; D002331:Carnitine
Vliianie pal'mitoil-KoA na energizatsiiu mitokhondriĭ pri ego vzaimodeĭstvii s adeninnukleotid-translokazoĭ.