In vitro studies on information transfer in cells from allotype-suppressed rabbits.
Data are presented which show that cells from allotypically suppressed rabbits resist in vitro "rescue" attempts in which informational ribonucleic acid (i-RNA) coding for the suppressed allotypic marker is used. It is shown that peritoneal exudate cells from such thoroughly suppressed animals contain cells that yield i-RNA coding for the suppressed marker, and that central lymphatic tissue possesses cells that produce Ig of the suppressed type.
D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002478:Cells, Cultured; D000939:Epitopes; D005260:Female; D007106:Immune Sera / Q000302:isolation & purification; D007111:Immunity, Cellular; D007126:Immunoglobulin Allotypes; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D012313:RNA / Q000032:analysis*; D011817:Rabbits / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D014158:Transcription, Genetic
D000939:Epitopes; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D011947:Receptors, Antigen, B-Cell; D012313:RNA