Some central nervous actions of centrophenoxine (Meclofenoxat) in animals.
In experiments with rats and mice it was been found that centrophenoxine in acute experiments in large doses has inhibitory effects on the central nervous system. Centrophenoxine has no analgesic action. When administered subchronically, centrophenoxine aggravates both the pentetrazol and the maximal electroshock seizures.
D000758:Anesthesia; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004357:Drug Synergism; D004597:Electroshock; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced
D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D006016:Glycolates; D006591:Hexobarbital; D002504:Meclofenoxate; D010433:Pentylenetetrazole