Airway sensitivity to slow-reacting substance of anaphylaxis, histamine, and antigen in Ascaris sensitive monkeys.
The effects of Ascaris suum antigen, histamine, and slow-reacting substance of anaphylaxis (SRS-A) on the respiratory system were compared in 3 anesthetized rhesus monkeys. The agents were administered by instillation into the trachea, and the animals were studied in a volume displacement body plethysmograph. Two of the animals showed skin and bronchial sensitivity to Ascaris suum antigen and responded to it with increased pulmonary resistance and decreased dynamic compliance. A similar response was seen in all 3 animals after instillation of histamine, but SRS-A at 2 concentrations produced a predominant effect of decreased dynamic compliance with lesser alterations in pulmonary resistance. The effects of SRS-A were slow in onset and prolonged, as compared to the abrupt and short-lived effects of Ascaris suum antigen and histamine. The predominant effect of SRS-A on dynamic compliance suggests a more peripheral site of action of this mediator. In 5 monkeys allergic to Ascaris, no SRS-A could be detected in the blood at one and 5 min after antigen challenge, using the bioassay techniques.
D000287:Administration, Topical; D000403:Airway Resistance / Q000187:drug effects*; D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology*; D012898:Autacoids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000503:physiopathology; D005652:Functional Residual Capacity; D000882:Haplorhini; D006632:Histamine / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects*; D008253:Macaca mulatta; D012115:Residual Volume; D012882:Skin Tests; D014109:Total Lung Capacity
D000941:Antigens; D012898:Autacoids; D006632:Histamine