Chemical characterization of decomposition products of drugs. Part 6. Mass spectrometry of some perazine derivatives.
Mass spectra of perazine, prochlorperazine, tiethylperazine, trifluperazine, butaperazine and thioproperazine were obtained. All possible fragmentation routes were discussed. The mechanism of fragmentations, their similarities and differences within the investigated group of compounds were established. The Hammett type relationship was found between the intensities of some ions and the kind of substituents at the C2 position. The utility of mass spectra for the prediction of drug stability was demonstrated.
D014150:Antipsychotic Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry; D010464:Perazine / Q000031:analogs & derivatives / Q000032:analysis*
D014150:Antipsychotic Agents; D010464:Perazine