Liver reaction to tissue injury: do therapeutic measures trigger the acute phase reaction?
In 30 healthy people we investigated the hypothesis that therapeutic measures trigger the acute phase reaction. In order of severity we analyzed: (1) the effects of an intramuscular injection of 2.5 ml 0.14 molar NaCl (6 patients), (2) the effects of an indwelling venous catheter for 24 h (7 patients), and for 72 h (8 patients), (3) the effects of cardiac catheterization (arterial and venous catheterization) carried out in 9 patients. In clinical investigations of the acute phase reaction, an intramuscular injection and a 24- or 72-h indwelling catheter, brought in by venipuncture, are acceptable because they do not provoke an acute phase reaction. A venous cutdown associated with an arterial puncture is not acceptable because this injury evokes a positive acute phase reaction. This was also observed in two patients who developed phlebitis during a 24-h indwelling venous catheter. Only a positive acute phase reaction was found, not a negative one.
D000208:Acute Disease; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002404:Catheterization; D005340:Fibrinogen / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D006023:Glycoproteins; D006242:Haptoglobins; D012709:Serum Albumin; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D012965:Sodium Chloride; D005340:Fibrinogen; D002097:C-Reactive Protein