Androgen of the human prostate.
The relationship between the concentrations of total and apparent free testosterone in the plasma and the levels of testosterone (T), dihydrotestosterone (DHT) and 5 alpha-androstan-3-alpha, 17 beta-diol (DIOL) in 13 benign hypertrophic and 6 carcinomatous prostates was studied. The androgen concentration within both types of glands was nearly 4-fold that in the blood but bore no direct relationship to the blood level. About 75% of the androgen in the tissue was DHT. The most striking finding was that, in spite of a 25.5% less concentrated pool of apparent free testosterone in the blood, the level of T and its metabolites in the cancer tissue was 29% above that in the samples of benign hypertrophic prostate.
D000728:Androgens / Q000097:blood / Q000378:metabolism*; D015113:Androstane-3,17-diol / Q000378:metabolism; D003900:Desoxycorticosterone / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D009928:Organ Specificity; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism; D012737:Sex Factors; D013739:Testosterone / Q000378:metabolism
D000728:Androgens; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D003900:Desoxycorticosterone