Effect of coumarin and some coumarin derivatives on active transport and passive diffusion of sugars by chicken and rat intestine, in vitro.
The effect of coumarin, 4-hydroxycoumarin, coumarin-3-carboxylic acid and acenocoumarol on the active transport of D-galactose and the passive diffusion of arabinose by intestinal sacs was studied. All these substances, when added to the mucosal medium of incubation at concentrations from 10(-4) to 10(-3) M, inhibit the active transport of D-galactose and increase the diffusion of arabinose. Oxygen uptake by the intestinal tissue is only inhibited by coumarin-3-carboxylic acid. The results suggest that the effects obtained are probably due to an alteration in intestinal permeability, to inhibition of cell metabolism and to molecular size.
D000074:Acenocoumarol / Q000494:pharmacology; D000818:Animals; D001089:Arabinose / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D002645:Chickens; D003374:Coumarins / Q000494:pharmacology*; D004058:Diffusion; D005260:Female; D005690:Galactose / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption; D051381:Rats
D003374:Coumarins; D001089:Arabinose; D000074:Acenocoumarol; D005690:Galactose