Effect of butyldiiodohydroxybenzoate on pituitary-thyroid interplay.
The effect of BHDB, an analogue of thyroxine, on the pituitary-thyroid system was studied in the rat. BHDB produced low plasma T4 and T3 concentrations similar to those produced by methimazole, but failed to elevate plasma TSH and to produce goiter because of displacement of T4 from the binding protein. Low plasma thyroid hormone concentrations were due to an increase of fecal loss of thyroid hormones. By releasing excess iodide, BHDB blocked the development of goiter produced by methimazole.
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D006042:Goiter / Q000139:chemically induced; D007455:Iodine / Q000378:metabolism; D007463:Iodobenzoates / Q000494:pharmacology*; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects*; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood*
D013956:Antithyroid Agents; D007463:Iodobenzoates; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D008713:Methimazole; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine