Modification of chronic hepatitis-B virus infection in chimpanzees by administration of an interferon inducer.
Chimpanzees chronically infected with hepatitis-B virus showed transient changes in several markers of infection when treated with the interferon inducer polyriboinosinic-polyribocytidylic acid-poly-l-lysine carboxymethyl cellulose. Serum Dane-particle-associated D.N.A. polymerase, e antigen and hepatitis-B surface antigen, and intrahepatic hepatitis-B surface and core antigens diminished during treatment. Defective (D.N.A.-polymerase-negative) Dane particles increased in titre transiently during treatment; these may play a role in the modulation of hepatitis-B virus infection. Humoral immune responses in chronic hepatitis-B carrier chimps were unaffected. Interferon inducers (or exogenous interferon) may be useful for the treatment of chronic hepatitis-B virus infection.
D000818:Animals; D002908:Chronic Disease; D007181:Inclusion Bodies, Viral; D007369:Interferon Inducers / Q000494:pharmacology* / Q000627:therapeutic use; D007372:Interferons / Q000097:blood; D008099:Liver / Q000276:immunology; D002679:Pan troglodytes; D011070:Poly I-C / Q000031:analogs & derivatives* / Q000494:pharmacology
D007369:Interferon Inducers; D007372:Interferons; D011070:Poly I-C