title: Effect of drug content and drug particle size on the change in particle size during tablet compression.
abstract: Three size fractions for each of three poorly soluble drugs were compressed into 10 mm diameter tablets of four different dilution ratios. The compression was carried out on a physical testing instrument at four compression levels of 49.0, 98.1, 196.2 and 294.3 MN m-2. The effect of drug content and drug particle size on the change in particle size during tableting was examined by the determination of the dissolution rate for disintegrated tablets. A linear relation was obtained when plotting 1n(T80%) versus drug content. There was a critical particle size where the phenomena of cleavage and bonding during tableting balanced each other, but this varied with drug content.
mesh_terms: D002626:Chemistry, Pharmaceutical; D002701:Chloramphenicol; D004339:Drug Compounding; D010316:Particle Size; D010615:Phenacetin; D011239:Prednisolone; D011312:Pressure; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D002701:Chloramphenicol; D011239:Prednisolone; D010615:Phenacetin