Congenital abnormalities and Perthes' disease. Clinical evidence that children with Perthes' disease may have a major congenital defect.
This paper reports a high incidence of minor congenital anomalies in boys and girls with Perthes' disease compared with that in a control population. There is a similarity of the incidence of minor anomalies in the children with Perthes' disease to that in babies with a single major congenital defect. Multiple major defects were more numerous and more severe than in the control children. It is speculated that there may be a congenital abnormality affecting skeletal development which in some way makes the hip susceptible to Perthes' disease at a later date.
D000015:Abnormalities, Multiple / Q000453:epidemiology; D001724:Birth Weight; D002648:Child; D003456:Cryptorchidism / Q000150:complications; D004739:England; D004827:Epilepsy / Q000150:complications; D005145:Face / Q000002:abnormalities; D005260:Female; D005271:Femur Head Necrosis / Q000150:complications*; D006467:Hemophilia A / Q000150:complications; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000150:complications* / Q000453:epidemiology; D008297:Male; D012959:Socioeconomic Factors