Carcinogenic effect of di-isopropanolnitrosamine on the rat thyroid gland.
Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, adenomas were observed as early as 18 weeks after commencement of treatment. Most adenocarcinomas could be observed macroscopically, and frequently demonstrated infiltration into the surrounding muscles.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects; D013964:Thyroid Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; C012457:diisopropanolnitrosamine