title: Codeine intoxication in childhood.
abstract: Clinical reports on 430 children with acute codeine intoxication are evaluated. Of 234 children who had taken more than 5 mg/kg body-weight, 8 had respiratroy arrest necessitating intubation and artificial ventilation; 2 of them died. In all other cases the intoxication produced one or more of the following symptoms: somnolence, ataxia, miosis, vomiting, rash, swelling, and itching of the skin, but no life-threatening side-effects. Close supervision of respiration is the main principle of management when more than 2 mg codeine/kg body-weight has been taken. Gastric voiding may be useful if done soon after ingestion. Charcoal and purgatives should be given in all cases.
mesh_terms: D000996:Antitussive Agents / Q000008:administration & dosage / Q000506:poisoning*; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003061:Codeine / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000628:therapy; D012151:Resuscitation; D013997:Time Factors
chemical_list: D000996:Antitussive Agents; D003061:Codeine