Haemodynamic effects of the carboxylic ionophore monensin when administered before and during shock induced by E. coli endotoxin.
The haemodynamic effects of the carboxylic ionophore monensin have been examined in cats anaesthetized with sodium pentobarbitone. Marked increases in left ventricular dP/dtmax (and dP/dt at fixed isovolumic pressures) and slight increases in cardiac output and stroke volume occurred, indicating increased myocardial contractility. Heart rate was unchanged but systemic arterial pressure was substantially increased. Satisfactory increases in contractility and arterial pressure were obtained when monensin was infused intravenously in a total dose of 0.25 mg kg-1 over 10 min. Larger doses, especially if rapidly injected, resulted in very marked increases in myocardial contractility leading eventually to cardiac failure. The haemodynamic effects of monensin were markedly reduced during shock induced by E. coli endotoxin and there was unfortunately no evidence to suggest that this extremely potent compound might be potentially beneficial in this form of profound cardiovascular shock.
D000818:Animals; D002415:Cats; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D005260:Female; D005663:Furans / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008985:Monensin / Q000494:pharmacology*; D012772:Shock, Septic / Q000503:physiopathology*; D013997:Time Factors
D004731:Endotoxins; D005663:Furans; D008985:Monensin