Is vasopressin involved in the pathogenesis of malignant desoxycorticosterone hypertension in rats?
Rats with unilateral nephrectomy were offered 1% sodium chloride as drinking fluid and were injected with desoxycorticosterone trimethylacetate (D.O.C.-T.M.A.) at weekly intervals. During the fourth to seventh week after the start of the experiment, malignant hypertension developed in most  of the animals: body weight fell, reflecting volume depletion; serum osmolality and serum sodium and urea concentrations increased; in the kidneys malignant nephrosclerosis occurred. In such animals, plasma concentrations of arginine-vasopressin were increased ten-fold in comparison with control animals; intravenous injection of a specific vasopressin antibody resulted in a transient fall of blood-pressure (B.P.) to normal or subnormal levels, while the injection of an angiotensin-I or angiotensin-II antibody did not affect B.P. In control animals none of the antibodies had an effect on B.P. It is concluded that in the pathogenesis of malignant D.O.C. hypertension vasopressin plays a role similar to that of renin-angiotensin in malignant renal hypertension.
D000804:Angiotensin II / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D001127:Arginine Vasopressin / Q000097:blood / Q000276:immunology / Q000502:physiology; D001794:Blood Pressure; D001835:Body Weight; D003900:Desoxycorticosterone / Q000008:administration & dosage; D004435:Eating; D006974:Hypertension, Malignant / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood; D014667:Vasopressins / Q000031:analogs & derivatives*
D000906:Antibodies; D014667:Vasopressins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D003900:Desoxycorticosterone; D014508:Urea; D012964:Sodium