title: [Changes of serum proteins after craniocerebral trauma - comparison of alpha 2 and alpha 2M (author's transl)].
abstract: Quantitive estimations of serum proteins, including Alpha 2M globulin, from 34 patients suffering from craniocerbral trauma have been carried out. The mean value curves over a period of two weeks following trauma are presented graphically. After severe injuries, depending on the size of the cerebral lesions, an increase in Alpha 2 of prognostic significance has been observed. Levels of Alpha 2M do not correlate directly with Alpha 2 globulin, and tend to fall initially. Falls in the first three days after injury may be prognostically significant from the point of view of the prediction of a lethal outcome. There are no significant changes in the levels of total protein, albumin, Beta globulin or Gamma globulin, but Alpha 1 globulin follows the curve of Alpha 2, although to a less marked degree. Correlations between serum protease activites and increases in Alpha 2 due to enzymatically active complexes are unconnected with Alpha 2M, a decrease in which indicates increased inhibitor activity and exhaustion of the inhibitor system.
mesh_terms: D000510:Alpha-Globulins / Q000378:metabolism*; D001609:Beta-Globulins / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D001930:Brain Injuries / Q000097:blood*; D005260:Female; D006408:Hematoma, Subdural / Q000097:blood; D006801:Humans; D008297:Male; D011379:Prognosis; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000378:metabolism*; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D005719:gamma-Globulins
vernacular_title: Serumproteinveränderungen bei Patienten mit Schädel-Hirn-Trauma - Vergleich zwischen alpha2-und alpha2M-Globulinabweichungen