Inhibition of 4,alpha-dimethyl-m-tyramine (H 77/77)-induced hypermotility in rats by single and repeated administration of chloropromazine, haloperidol, clozapine and thioridazine.
The effect of H 77/77 (5 mg/kg s.c.) on motility of rats kept in a familiar cage was investigated. H 77/77 produced hypermotility, which was reduced by oral pretreatment with chlorpromazine, haloperidol, clozapine and thioridazine. The 4 neuroleptics were administered acutely and for a 14 day period. H 77/77 was given 30 min after the single or last dose of neuroleptc (chronic treatment) condition. After both single and repeated administration the neuroleptics showed H 77/77-antagonism in doses ranging from 0.1-2.0 mg/kg. The effect on H 77/77 activity did not change significantly after repeated treatment. Clozapine and thioridazine, which clinically produce only minor extrapyramidal side effects, exert a weak effect or none at all in tests commonly used for neuroleptic activity. These 2 neuroleptics were potent H 77/77-antagonists. Inhibition of H 77/77-hypermotility may possibly be used as a test for neuroleptics.
D018663:Adrenergic Agents / Q000037:antagonists & inhibitors; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006220:Haloperidol / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013881:Thioridazine / Q000494:pharmacology; D014439:Tyramine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology
D018663:Adrenergic Agents; D014150:Antipsychotic Agents; D003024:Clozapine; D006220:Haloperidol; D013881:Thioridazine; D002746:Chlorpromazine; D014439:Tyramine