title: Antiviral effect of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxyazolyl-(2)]hydrazone (IMET 98/69) in mice.
abstract: The potential in vivo antiviral activity of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxazolyl-(2)]-hydrazone (IMET 98/69) was evaluated on model infections in mice. Animals treated subcutaneously (s.c.) with 1 mmole of the drug per kg body weight once daily for five days were significantly protected against a lethal infection with cardioviruses, Semliki forest virus and vaccinia virus. In influenza A and B virus models no antiviral activity was observed either after s.c. or oral treatment.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001102:Arbovirus Infections / Q000517:prevention & control; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000517:prevention & control; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control; D010080:Oxazoles / Q000031:analogs & derivatives / Q000627:therapeutic use; D012328:RNA Viruses; D012672:Semliki forest virus; D014615:Vaccinia / Q000517:prevention & control; D014777:Virus Diseases / Q000517:prevention & control*
chemical_list: D000998:Antiviral Agents; D010080:Oxazoles; C016864:IMET 98-69