In vitro study of phenothiazine effects on urinary bladder.
Clinical observations suggest that long-term phenothiazine therapy can cause urinary retention and stress incontinence. The phenothiazines, chlorpromazine and perchlorperazine, depress bladder smooth muscle activity in vitro by depressing bladder smooth muscle activity directly and by a peripheral cholinergic blocking action.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003864:Depression, Chemical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics; D011346:Prochlorperazine / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects*
D014150:Antipsychotic Agents; D010276:Parasympatholytics; D002746:Chlorpromazine; D011346:Prochlorperazine