title: [Development of the ideas of N. N. Anichkov at the present stage of our knowledge about atherosclerosis].
abstract: The article discusses the main elements of the infiltrative-combination theory of atherosclerosis, which was formulated and developed by N. N. Anichkov. The further development of the main principles of this theory at the current stage of medical science is elucidated. Analysis of the mechanisms of penetration of lipids into the vascular wall, the role of metabolism of the main substance and plasmic proteins at the initial stages of atherosclerosis shows that the new data obtained are not at variance with the fundamental principles of the N. N. Anichkov's theory but on the contrary, supplement it. Evidences on the role of immune complex of beta-lipoproteid-gamma-globulin in the development of atherosclerosis are also in complete accord with this theory.
mesh_terms: D000818:Animals; D001158:Arteries / Q000276:immunology / Q000378:metabolism*; D001161:Arteriosclerosis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002645:Chickens; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D051381:Rats; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D008077:Lipoproteins, LDL; D005719:gamma-Globulins
vernacular_title: Razvitie ideĭ N. N. Anichkova na sovremennom étape ucheniia ob ateroskleroze