Post-transfusion hepatitis: the role of hepatitis B antibody.
Aliquots from units of blood previously transfused as part of a prospective post-transfusion hepatitis (PTH) study were rescreened for the presence of hepatitis B antibody (anti-HBS) to determine the effect of transfusion of such material. Anti-HBS was more commin in commercial blood. Infusion of anti-HBS was not associated with an increased or decreased risk of PTH, hepatitis B, or hepatitis B (HB) exposure. Receipt of anti-HBS did not modify the hepatitis which occurred. Receipt of large amounts of anti-HBS may be associated with an increased incidence of HB events. Preexisting anti-HBS was not only not protective against PTH, but more PTH (67% versus 40%) and hepatitis B (47% versus 12%) were seen in those patients with it.
D000906:Antibodies; D001782:Blood Donors; D006509:Hepatitis B / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D013997:Time Factors; D065227:Transfusion Reaction; D005719:gamma-Globulins / Q000627:therapeutic use
D000906:Antibodies; D005719:gamma-Globulins