title: [Neuroleptic disinhibitory agents].
abstract: The concept of "disinhibition" appeared in 1956 (Broussolle and Dubor) with a study of the activity of prochlorpémazine in chronic schizophrenia. Each chemical group of neuroleptics includes at least one or two disinhibitory compounds. This activity intervenes upon the affective and intellectual life without necessarily the usual extra-pyramidal akathisia side-effects. Psycho- and sociotherapy are strongly adviced with disinhibitory effect.
mesh_terms: D000339:Affect / Q000187:drug effects; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007266:Inhibition, Psychological; D007360:Intelligence / Q000187:drug effects; D010640:Phenothiazines; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D010640:Phenothiazines
vernacular_title: Neuroleptiques désinhibiteurs.