The deficiency of cyclic AMP responsive G1 controls in cultured malignant liver epithelial cells.
Normal rat liver epithelial cells in culture were blocked outside the S phase by dibutyryl cyclic AMP while malignant rat liver epithelial cells were slowed in S phase. It is suggested that this lack of normal response to a growth inhibitory factor by malignant cells may underly their relatively autonomous growth behavior.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D016193:G1 Phase / Q000502:physiology*; D008099:Liver / Q000166:cytology* / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D051381:Rats; D016196:S Phase / Q000502:physiology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D014316:Tritium; D003994:Bucladesine; D013936:Thymidine