Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.
A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens-carcinogens. The test gives a very sensitive and rapid method for detecting chromosome mutagenicity of chemical agents and provides a powerful new method for detecting environmental mutagens.
D001973:Bromodeoxyuridine / Q000378:metabolism; D002273:Carcinogens / Q000032:analysis; D002460:Cell Line; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000528:radiation effects; D003434:Crossing Over, Genetic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009153:Mutagens / Q000032:analysis; D011831:Radiation Genetics; D013194:Staining and Labeling; D014965:X-Rays
D002273:Carcinogens; D009153:Mutagens; D001973:Bromodeoxyuridine