[Kinetics of phenazepam-14C excretion from the body of white rats in the single and prolonged administration of the preparation].
During 5 days after intraperitoneal injection of 14C-phenazepam into albino rats, about 77% of the total radioactivity was excreted with urine and feces in both intact animals and in those premedicated with phenazepam for 15 days. The excretory processes are described by the first order equations. The rates of phenazepam total excretion are identical in single and repeated injections. At the same time, phenazepam injected into the animals at a single dose is predominantly excreted with urine, while in multiple administration it is excreted with feces. Excretion of phenazepam with urine acquires the biexponential features, provided it is injected in multiple doses.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000652:urine*; D001569:Benzodiazepines; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D051381:Rats; D013997:Time Factors
D014151:Anti-Anxiety Agents; D002250:Carbon Radioisotopes; D001569:Benzodiazepines; C017928:phenazepam
Kinetika vyvedeniia fenazepama-14C iz organizma belykh krys pri odnokratnom i dlitel'nom vvedenii preparata.