title: Meningococcal infections in Bolton, 1971-74.
abstract: Between December 1970, and the end of June, 1974, there were 82 cases of meningococcal infection, including 14 deaths, in the metropolitan borough of Bolton. This outbreak, caused by a sulphonamide-sensitive group-B strain, was characterised by a high attack-rate in young children, reaching a peak of 184 per 100,000 per year in the 6-11-month age-group. All the deaths were in children under 3 years of age. Nasopharyngeal carriage of the epidemic strain was found in 34% of close family contacts investigated before receiving sulphonamide prophylaxis.
mesh_terms: D000367:Age Factors; D002353:Carrier State; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000453:epidemiology*; D004352:Drug Resistance, Microbial; D004739:England; D005191:Family Characteristics; D006801:Humans; D007223:Infant; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D009345:Neisseria meningitidis / Q000187:drug effects / Q000302:isolation & purification; D012621:Seasons; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D013449:Sulfonamides