title: Impaired performance and sedation after a single dose of lorazepam.
abstract: In a double-blind cross-over study using normal student volunteers, the effects of 1 and 2.5 mg lorazepam on self-rated mood and bodily symptoms, as well as performance in a number of tests were assessed. Both doses significantly increased self ratings of physical and mental sedation, the effects being more marked 4 h after drug administration than after 1 h. Lorazepam impaired simple reaction time, verbal learning, number cancellation, symbol copying and performance in the digit-symbol substitution test. The impairments were greater with the 2.5 mg dose and were more marked 4 h after drug administration than after 1 h.
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D007361:Intelligence Tests; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D008606:Mental Processes / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014706:Verbal Learning / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D008140:Lorazepam