[Effect of a chronic alpha adrenergic receptor blockade on basal secretion of renin in essential hypertension].
To investigate the effect of chronic alpha-adrenergic receptor blockade on renin release, plasma renin activity (PRA) was determined overnight at short intervals in 9 patients with essential hypertension before and after 7 days medication with phenoxybenzamine (20 mg orally/day). Inhibition of basal (supine) renin secretion in response to alpha-adrenergic receptor blockade was more apparent in patients with elevated PRA (n = 3) than in those with normal PRA. On the other hand, patients with low PRA (n = 2) even showed an increase in renin release. In addition, night-day variations with secretory episodes in PRA were blunted during drug administration. It is suggested that alpha-adrenergic receptor blockade inhibits renin secretion distal to its blockade of specific adrenergic receptors. However, the increase in renin release during phenoxybenzamine observed in patients with low PRA indicates that the responsiveness of renin secretion to stimulatory effects (most probably induced by the lowered blood pressure in our patients) remained intact during alpha-adrenergic receptor blockade.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D012083:Renin / Q000378:metabolism*; D012636:Secretory Rate; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D010643:Phenoxybenzamine; D012083:Renin
Einfluss einer chronischen alpha-adrenergen Rezeptorenblockade auf die basale Reninsekretion bei essentieller Hypertonie.