Correlation between the increase in tyrosine hydroxylase activity and the decrease in serotonin content in the rat locus coeruleus after 5,6-dihydroxytryptamine.
A correlation is demonstrated between the increase in tyrosine hydroxylase activity and the decrease in serotonin concentration in the rat locus coeruleus after various doses of 5,6-dihydroxytryptamine and gradual protection of serotonin neurons by pretreatment with two serotonin uptake inhibitors: fluoxetine or citalopram.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D008125:Locus Coeruleus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009411:Nerve Endings / Q000378:metabolism; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D001572:Benzofurans; D011437:Propylamines; D012702:Serotonin Antagonists; D005473:Fluoxetine; D012701:Serotonin; D014446:Tyrosine 3-Monooxygenase; D015115:5,6-Dihydroxytryptamine