Tumor-associated antigens in isoantigenic variants of a 3-methylcholanthrene-induced sarcoma.
A sarcoma was induced in an (A.CA X A.BY)F1 mouse. Two isoantigenic variants were selected by loss of one H-2 antigen. The tumor-associated transplantation antigens (TATA) of these variants were compared as to their specificities in (A.CA X A.BY)F1 mice. Both transplantation and indirect membrane immunfluorescence tests revealed that TATA of both variants did not cross-react. Thus selecting angainst different H-2 antigens also selected different TATA. Karyotype studies suggested that both variants originated from a unique clone.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002999:Clone Cells; D003429:Cross Reactions; D000939:Epitopes; D006579:Heterozygote; D006649:Histocompatibility Antigens; D007621:Karyotyping; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm; D000939:Epitopes; D006649:Histocompatibility Antigens; D008748:Methylcholanthrene