Effect of a single dose of dexamethasone on serum concentrations of thyroid hormones.
In ten euthyroid subjects, in whom endogenous thyroid-stimulating hormone (T.S.H.) production was suppressed by oral thyroxine (T4), a single dose of dexamethasone resulted in reduced serum-3,3'5-triidothyronine (T3) concentration and raised serum-3,3',5'-triiodothyronine (reverse T3 or rT3) concentration after 24 h. These changes were not related to changes in free hormones or binding proteins. Adrenal glucocorticoids may have a pathophysiological role in modulating the peripheral metabolism of thyroid hormones in stress.
D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D013315:Stress, Psychological; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000097:blood / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
D013963:Thyroid Hormones; D014284:Triiodothyronine; D003907:Dexamethasone; D013972:Thyrotropin; D013974:Thyroxine