[Changes in the biological activity of androgens after the exposure of cockerels to lindane].
A biological test was performed to study the changes in the effectiveness of androgens after the administration of different doses of lindane to sexually immature cockerels. Testosterone-propionate and Stenolon were used as reference hormones. The results indicate that the administration of lindane increases the biological effectiveness of testosterone-propionate expressed through the stimulation of the growth of comb. On the other hand, the effect of the insecticide caused a statistically highly significant reduction of androgenic activity when Stenolon was used as a reference preparation. The causes leading to different manifestations of the interactions of lindane with the two hormones tested are analyzed. The paper gives further proofs that the exposure of poultry to relatively low doses of chlorinated insecticides interferes with the biological effectiveness of sex hromones.
D000818:Animals; D002645:Chickens / Q000378:metabolism; D003129:Comb and Wattles / Q000254:growth & development; D004347:Drug Interactions; D001556:Hexachlorocyclohexane / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
D013739:Testosterone; D001556:Hexachlorocyclohexane
Zmeny v biologickej úcinnosti androgénov po expozícii kohútikov lindanu