title: Effect of anabolic steroids on plasma antithrombin III. alpha2 macroglobulin and alpha1 antitrypsin levels.
abstract: The effect of seven different anabolic steroids (Ethyloestrenol, Methenolone acetate, Norethandrolone, Methylandrostenediol, Oxymetholone, Methandienone, and Stanozolol) on three alpha-globulin antiprotease inhibitors of thrombin and plasmin was studied in men with ischaemic heart disease. In distinct contrast to the oral contraceptives, five of the six 17-alpha-alkylated anabolic steroids studied produced increased plasma Antithrombin III levels and five produced decreased levels of plasma alpha2-macroglobulin. The effect on plasma alpha1-antitrypsin levels was less clear-cut but three of the steroids examined produced significantly elevated levels. The increased plasma fibrinolytic activity which the 17-alpha-alkylated anabolic steroids induce is therefore unlikely to be secondary to disseminated intravascular coagulation.
mesh_terms: D000328:Adult; D000368:Aged; D045930:Anabolic Agents / Q000494:pharmacology*; D000991:Antithrombins / Q000378:metabolism*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D005032:Ethylestrenol / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008695:Methandriol / Q000494:pharmacology; D008696:Methandrostenolone / Q000494:pharmacology; D008710:Methenolone / Q000494:pharmacology; D008875:Middle Aged; D009639:Norethandrolone / Q000494:pharmacology; D010110:Oxymetholone / Q000494:pharmacology; D013197:Stanozolol / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
chemical_list: D045930:Anabolic Agents; D000991:Antithrombins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D013197:Stanozolol; D008695:Methandriol; D008710:Methenolone; D005032:Ethylestrenol; D008696:Methandrostenolone; D010110:Oxymetholone; D009639:Norethandrolone