[Hypothalamo-hypophysial-thymic axis in the rat].
Thymic extracts, with proved immunologic properties, decrease, in vitro, RNA and DNA synthesis of hypothalamic fragments of adult rat and have no effect on hypophysis culture; we found a similar action in vivo. Growth hormone inhibits the nucleic acids synthesis of thymic fragments; no action is found with hypothalamic extracts. Hypothesis, that thymic activity is dependent on hypophysis with retroaction on hypothalamus, is discussed.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D013006:Growth Hormone / Q000502:physiology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013950:Thymus Gland / Q000276:immunology / Q000502:physiology*
D012313:RNA; D013006:Growth Hormone; D004247:DNA
Contribution à l'étude de l'axe hypothalamo-hypophyso-thymique chez le rat