The effect of baclofen and aminoxyacetic acid on catalepsy in the rat.
Gabaergic compounds, baclofen and aminoxyacetic acid (AOAA) potentiate the catalepsy induced by neuroleptics. This effect indicates their functional antagonism towards the central dopaminergic system. Both compounds exert a central antiserotonin effect. Baclofen, but not AOAA, also shows weak cholinolytic properties. However, the potentiation of cataleptogenic action of neuroleptics by baclofen and AOAA is not related to their effect on the central serotonergic or cholinergic systems.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000085:Acetates / Q000494:pharmacology*; D000613:Aminobutyrates / Q000494:pharmacology*; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001418:Baclofen / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D004347:Drug Interactions; D006801:Humans; D008297:Male; D051381:Rats; D013997:Time Factors; D014203:Tremorine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000085:Acetates; D000613:Aminobutyrates; D014150:Antipsychotic Agents; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D006916:5-Hydroxytryptophan; D001418:Baclofen; D014203:Tremorine