Cyclophosphamide treatment in steroid-sensitive nephrotic syndrome of childhood.
An  8-week course of 3 mg. per kg. body-weight per day of cyclophosphamide was administered to eighty-two children with steroid-senstitive nephrotic syndrome. One died, and of the remainder, 69% were in remission after 1 year and 44% after 4-years. Older children and those in whom cyclophosphamide was given during a steroid-maintained remission fared better.
D000284:Administration, Oral; D000293:Adolescent; D000419:Albuminuria / Q000175:diagnosis; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins; D003401:Creatine / Q000652:urine; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000302:isolation & purification; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011507:Proteinuria / Q000188:drug therapy; D012008:Recurrence; D012075:Remission, Spontaneous; D013997:Time Factors
D007074:Immunoglobulin G; D003520:Cyclophosphamide; D003165:Complement System Proteins; D011239:Prednisolone; D003401:Creatine