Oxidation of D-thiazolidine-4-carboxylic acid by hog kidney D-aminoacid oxidase.
D-Thiazolidine-4-carboxylic acid is a good substrate for hog kidney D-aminoacid oxidase. Data are presented showing that the only oxidation product is delta 3-thiazoline-4-carboxylic acid, which does not undergo further spontaneous degradation. Thus, the oxidation of D-thiazolidine-4-carboxylic acid by D-aminoacid oxidase differs considerably from the oxidation of its L-isomer catalyzed by rat liver mitochondria which gives as final product N-formylcystine, possibly through the intermediate delta 2-thiazoline-4-carboxylic acid.
D000818:Animals; D003545:Cysteine / Q000378:metabolism; D003605:D-Amino-Acid Oxidase / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D013552:Swine / Q000378:metabolism*; D013844:Thiazoles / Q000378:metabolism*; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; C003438:thiazolidine-4-carboxylic acid; D003605:D-Amino-Acid Oxidase; D003545:Cysteine