[Relations between the levels of neuroleptics and the doses, the therapeutic effects and the side effects].
The mass fragmentography and the gas-liquid chromatography are available actually for quantitation of very low levels of neuroleptics. The Radio-immunological assay is full of promise. Their plasma levels are not correlated with their dosage in a man to another, but, for some of them, there is lineary relation for one person. A correlation between their levels and their clinical efficacy is not certainly demonstrated for thioridazine and non transformed chlorpromazine; it could be possible for his sulphoxide metabolite and for butaperazine. The sides-effects are relatively correlated with their levels in the begining of the therepautic. The antiparkinsonian drugs, the antidepressants and the lithium could influenced them.
D014150:Antipsychotic Agents / Q000009:adverse effects / Q000097:blood*; D001682:Biological Availability; D002746:Chlorpromazine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000097:blood; D006801:Humans; D008728:Methotrimeprazine / Q000097:blood; D010395:Penfluridol / Q000097:blood; D010546:Perphenazine / Q000097:blood; D010640:Phenothiazines / Q000097:blood; D013881:Thioridazine / Q000097:blood; D013888:Thiothixene / Q000097:blood; D014316:Tritium
D014150:Antipsychotic Agents; D010640:Phenothiazines; D014316:Tritium; D010395:Penfluridol; D013888:Thiothixene; D008728:Methotrimeprazine; D010546:Perphenazine; D006220:Haloperidol; D013881:Thioridazine; D002746:Chlorpromazine
Relation des taux des neuroleptiques avec les doses, les actions thérapeutiques et les effets secondaires.