title: Perivascular and intervascular reticular fibers of the retina.
abstract: We demonstrated the existence in the retina of an argyrophilic perivascular membrane comparable in all respects to that which exists throughout the vascular system. We compared our findings by light microscopy with those previously reported. We identified, by electron microscopy, the normal general location of the network between the basal laminae of the glial and vessel cells and demonstrated its selective staining with silver methenamine. These perivascular fibers, intercapillary strands, and bridges develop in relation to the process of retinal vascularization and the potential for forming these fibers is reactivated in senility and disease, as in diabetes. We summarized the evidence by concluding that these fibers are most likely composed of reticulin; it appears provable that in the past there may have been some confusion with neural fibers.
mesh_terms: D000367:Age Factors; D000368:Aged; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000648:ultrastructure; D003238:Connective Tissue / Q000032:analysis / Q000648:ultrastructure*; D003930:Diabetic Retinopathy / Q000473:pathology; D006801:Humans; D003012:Microbial Collagenase / Q000378:metabolism; D009457:Neuroglia / Q000648:ultrastructure; D010434:Pepsin A / Q000378:metabolism; D012155:Reticulin / Q000032:analysis; D012171:Retinal Vessels / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure*; D012834:Silver; D013194:Staining and Labeling; D014357:Trypsin / Q000378:metabolism
chemical_list: D012155:Reticulin; D012834:Silver; D014357:Trypsin; D010434:Pepsin A; D003012:Microbial Collagenase