[The influence of benzoctamine on dopamine and norepinephrine contents in substantia nigra and on the muscle stretch reflex of the cat (author's transl)].
The concentration of dopamine (DA) and norepinephrine (NE) are decreased to a maximum of 40% and 20%, respectively, in the substantia nigra of precollicular and prenigral decerebrated cats previously treated with benzoctamine (Tacitin) (0.7 mg/kg i.v.), while the tyrosine-hydroxylase and MAO activities remain unchanged. Muscle stretch reflexes recorded simultaneously showed a significant decrease of stretch tension which is evoked by a clear reduction of Ia discharges of the primary muscle spindle afferents. It would appear that benzoctamine suppresses reflexly evoked gamma-motoneurone discharges.
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D002415:Cats; D004298:Dopamine / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D000873:Anthracenes; D010293:Pargyline; D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine
Der Einfluss von Benzoctamin auf den Dopamin- und Noradrenalin-Gehalt der Substantia nigra und auf die Muskeldehnungsreflexe der Katze.