[The effect of organic phosphoric esters on the experimental peptic ulcer (author's transl)].
The authors have investigated some organic phosphoric esters such as dimethoate, malatione, and trichlorphone in order to see whether they influence the genesis of the reserpine ulcer induced in rats or whether they act on the existing ulcer. Another objective of the investigation was to determine whether the aggravating effect of these compounds on the experimental gastric ulcer can be mitigated or prevented with isopropamide and gastrixon, two compounds known to be used in the therapy of ulcers. It was found that 1. dimethoate and trichlorphone considerably aggravate the genesis of the experimental peptic ulcer in rats, and that also malathione exercises this exacerbating effect still to some extent, 2. that the already existing experimental ulcer is aggravated by all three organic phosphoric esters and that 3. the severe experimental damage to the stomach can be reduced or prevented with Isopropamide and even more effectively with Gastrixon. As to the interpretation of the phenomena observed the authors take the view that--provided the effects mentioned apply also to man--with this a new risk was detected in the field of the chemical plant protection which may well gain importance for the health of a population.
D000328:Adult; D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology*; D004117:Dimethoate / Q000494:pharmacology; D004952:Esters / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008294:Malathion / Q000494:pharmacology; D010437:Peptic Ulcer / Q000139:chemically induced; D010756:Phosphoric Acids / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use; D051381:Rats; D012110:Reserpine; D014236:Trichlorfon / Q000494:pharmacology
D002264:Carboxylic Acids; D004952:Esters; D010756:Phosphoric Acids; D000644:Quaternary Ammonium Compounds; D012110:Reserpine; D014236:Trichlorfon; D008294:Malathion; D004117:Dimethoate
Die Wirkung organischer Phosphorsäureester auf das experimentelle Magengeschwür.