Systemic amyloidosis in mice inoculated with lyophilized Candida cells.
Injection of lyophilized Candida albicans or C. parapsilosis cells induced amyloidosis in outbred CFW mice. The disease process was irreversible, and a significant number of animals died of systemic amyloidosis within 400 days after the last treatment. The techniques described may represent a model system for the study of systemic amyloidosis.
D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000209:etiology*; D000818:Animals; D002175:Candida; D005260:Female; D005612:Freeze Drying; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D051379:Mice; D013154:Spleen / Q000032:analysis; D013194:Staining and Labeling
D000682:Amyloid