[Effect of 1,4-benzodiazepine tranquilizers on the activity of the hepatocyte hydroxylating complex and glucose-6-phosphatase in white rats].
Intraperitoneal administration of diazepame and phenazepame into rats /at a dose 50 mg/kg/ within 4 days did not induce liver microsomal enzymes. After administration of chlordiazepoxide at the same dose content of cytochrome P-450 was increased and the rate of dimethylaniline demethylation was elevated. Content of protein as well as NADPH-cytochrome-c-reductase and glucose-6-phosphatase activities were increased after intraperitoneal administration of all the preparations at a dose 100 mg/kg within 4 days. Experiments on the potentiation of hexenal effect demonstrated the decrease in the time of sleep in animals, treated with chlordiazepoxide at a dose 100 mg/kg of body weight.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D003580:Cytochromes / Q000378:metabolism; D004361:Drug Tolerance; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D006900:Hydroxylation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats
D014151:Anti-Anxiety Agents; D003580:Cytochromes; D001569:Benzodiazepines; D005952:Glucose-6-Phosphatase
Vliianie trankvilizatorov 1,4-benzdiazipinovogo riada na aktivnost' gidroksiliruiushchego kompleksa i gliukozo-6-fosfatazy gepatotsitov belykh krys.