title: The effect of hydroxyethyl starch on in vitro platelet and granulocyte function.
abstract: The effect of hydroxyethyl starch (HES) on granulocyte and platelet functions was assessed. No alteration of granulocyte viability, morphology, phagocytic ability, or bactericidal capacity was detected after incubation with 6 per cent HES at 25 C for two hours. Platelet morphology, size distribution, aggregation, nucleotide and serotonin release, and platelet factor-3 availability were also unchanged after exposure to HES. It is concluded that HES has no adverse effect on cell function and appears to be a suitable adjuvant agent for blood cell component collection.
mesh_terms: D001770:Blood Bactericidal Activity / Q000187:drug effects; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects*; D001799:Blood Sedimentation; D002469:Cell Separation; D002470:Cell Survival; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects*; D009711:Nucleotides / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D013213:Starch / Q000031:analogs & derivatives*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D009711:Nucleotides; D012701:Serotonin; D013213:Starch