[Spin-lattice-relaxationtime-T1 measurements of hyaluronic acid (author's transl)].
Reductions with [3H5NaBH4 proof that the decrease in viscosity of hyaluronic acid solutions caused by lowering the pH does not depend on a depolymerisation of hyaluronic acid. At the same time investigations at different pH-values, show a sigmoide increase of the Spin-Lattice-Relaxationtime T1. This increase depends on a progressive aggregation of the hyaluronic acid molecule. The effect seems to be induced by the decrease of ionization of the carboxylgroups, by acidification of the solution.
D002236:Carbohydrate Conformation; D004578:Electron Spin Resonance Spectroscopy; D006820:Hyaluronic Acid; D006863:Hydrogen-Ion Concentration; D013816:Thermodynamics; D014783:Viscosity
D006820:Hyaluronic Acid
Spin-Gitter-Relaxationszeit-T1-Untersuchungen an Hyaluronsäure.