Modulation of human T lymphocyte rosette formation by serum factors.
It was determined that in the serum of TB patients, the factor (beta-lipoprotein) was present, lowering/modulating the ability of T lymphocyte rosette formation with SRBC. It was also found that in normal sera a factor is present which restores rosette formation with T lymphocytes from TB patients. The reaction of rosette inhibition factor and rosette restoring factor with xenogeneic cells, suggest that the reaction of the factors is not limited to modulation of spontaneous rosette formation only.
D000818:Animals; D006087:Graft vs Host Reaction; D006801:Humans; D007165:Immunosuppression Therapy; D008077:Lipoproteins, LDL / Q000276:immunology; D051379:Mice; D011453:Prostaglandins / Q000494:pharmacology; D012397:Rosette Formation; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000276:immunology*
D008077:Lipoproteins, LDL; D011453:Prostaglandins