Haemolysis of various mammalian erythrocytes in sodium chloride, glucose and phosphate-buffer solutions.
Mouse, rat, rabbit, hamster, cow, pig, sheep, guinea-pig, dog and human erythrocytes were studied. A 0.9% or stronger solution of sodium chloride completely prevented haemolysis; sheep and pig erythrocytes appeared the more fragile, while human and dog erythrocytes were not haemolized in concentrations of 0.4% or more. Haemolysis of human, rabbit, cow, hamster, guineapig, pig and sheep erythrocytes was not observed in solutions of 0.4% or more of glucose. Except for sheep, human and dog erythrocytes, haemolysis was depressed in rate but not completely prevented by phosphate-buffer solution of pH 7.0.
D000328:Adult; D000818:Animals; D002021:Buffers; D002417:Cattle / Q000097:blood; D006224:Cricetinae / Q000097:blood; D004285:Dogs / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology*; D006168:Guinea Pigs / Q000097:blood; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice / Q000097:blood; D010710:Phosphates / Q000494:pharmacology*; D011817:Rabbits / Q000097:blood; D051381:Rats / Q000097:blood; D012756:Sheep / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*; D013552:Swine / Q000097:blood
D002021:Buffers; D010710:Phosphates; D012965:Sodium Chloride; D005947:Glucose