[Sensitization of bradycardia during final hypotension induced by serotonin in rats: effect of lidocaine].
It was studied the sensibilizing effect of lidocaine (8.5 mg/kg, i.v.) on the ECG (heart rate, P-R interval, QRS complex and Q-T interval) of both intact and bilaterally vagotomised rats, in the nadir of the final hypotension determined by serotonine (60  mug/kg, i.v.). The results showed (1) a certain degree of selectivity of the vagi, and (2) the effects of serotonine either isolated or associated to lidocaine on P-R interval and heart rate were reinforced when intact animals were used. Although no significant alterations of Q-T were elicited by the drugs, lidocaine surprisingly enlarged the QRS complex in a more significant fashion for the intact than for the vagotomised animals.
D000818:Animals; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced*; D008012:Lidocaine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin; D014628:Vagotomy
D012701:Serotonin; D008012:Lidocaine
Sensibilisation de la bradycardie pendant l'hypotension finale déclenchée par la sérotonine chez le rat: effet de la lidocaine