title: Alpha fetoprotein in the antenatal diagnosis of the congenital nephrotic syndrome.
abstract: In the congenital nephrotic syndrome (Finnish type), concentrations of alpha fetoprotein in the amniotic fluid and maternal serum are markedly elevated in the second trimester of pregancncy. Demonstration of this alteration allows early prenatal diagnosis of this fatal condition and elective termination of the pregnancy before 20 week's gestation.
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009404:Nephrotic Syndrome / Q000151:congenital*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000097:blood
chemical_list: D005326:Fetal Proteins; D000509:alpha-Fetoproteins