Two cases of C-group balanced translocations.
The present study describes 2 cases of a balanced reciprocal translocation in the C-group of autosomes. Familial translocation 46,XX,t(6;7) was found both in a woman cytogenetically examined because of a developmental anomaly of the internal genitals (uterus bicornis subseptus) and in her healthy mother. Chromosomal complement 46,XYt(8;10) was proved in the healthy father of a child showing clinical features of Down's syndrome with a karyotype 47,XY,21+. Q- and G-banding techniques were used for precise identification of the chromosomes involved in translocations.
D000328:Adult; D002869:Chromosome Aberrations; D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D013194:Staining and Labeling; D014178:Translocation, Genetic; D014599:Uterus / Q000002:abnormalities