Single-dose peroperative antibiotic prophylaxis in gastrointestinal surgery.
A single intravenous dose of tobramycin and lincomycin, given at the start of gastrointestinal operations, significantly reduced the incidence of postoperative wound infection from 34% to 5%. The occurrence of both anaerobic and aerobic bacteria was reduced. Therapeutic concentrations of the antibiotics were maintained throughout the operative period in most cases. No toxic effects of the antibiotics were detected, no anaesthetic complication occurred, and resistant strains of bacteria normally sensitive to the antibiotics were not isolated from wounds.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001439:Bacteroides / Q000302:isolation & purification; D002986:Clinical Trials as Topic; D003016:Clostridium perfringens / Q000302:isolation & purification; D004338:Drug Combinations; D004341:Drug Evaluation; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005767:Gastrointestinal Diseases / Q000601:surgery*; D006801:Humans; D007263:Infusions, Parenteral; D008034:Lincomycin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D008875:Middle Aged; D011549:Pseudomonas / Q000302:isolation & purification; D013210:Staphylococcus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D014031:Tobramycin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D008034:Lincomycin; D014031:Tobramycin