[Method for determination of the bleomycin inactivating enzyme acitivity in tissues].
An enzyme that inactivates Bleomycin (BLM) can be extracted from tissue. The activity of this enzyme varies markedly in different tissues. In the present paper, a method is described by which the activity of the BLM-inactivating enzyme in different organs and tissues of mice can be determined. The highest activity is found in liver; lower enzyme concentrations occur in the testis, spleen, lung and brain. In skin this enzyme is almost completely missing.
D000818:Animals; D001761:Bleomycin / Q000037:antagonists & inhibitors*; D001921:Brain / Q000201:enzymology; D004798:Enzymes / Q000032:analysis*; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008297:Male; D051379:Mice; D012867:Skin / Q000201:enzymology; D013154:Spleen / Q000201:enzymology; D013737:Testis / Q000201:enzymology
D004798:Enzymes; D001761:Bleomycin
Methode zur Bestimmung der Bleomycin-inaktivierenden Enzymaktivität in Geweben