Evaluation of rapid radiation treatment schedules utilizing two treatment sessions per day.
The authors studied normal human skin reactions to two different rapid radiotherapy schedules of 2 sessions per day and evaluated their effectiveness in relief of pain and local tumor control. Patients were randomized to three treatment groups: SCHEDULE A (control): conventional one treatment per day regimen totalling 3,760 rads in 22-23 days; SCHEDULE B: 2 sessions per day totalling 3,440 rads in 10-11 days; and SCHEDULE C: 2 sessions per day totalling 3,568 rads in 10-11 days. The pattern and magnitude of skin reactions in the three schedules are nearly identical but tumor regression and pain relief were achieved faster in the rapid fractionation schedules.
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003300:Copper; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D010166:Palliative Care; D011830:Radiation Effects; D011868:Radioisotopes; D011879:Radiotherapy Dosage; D012867:Skin / Q000528:radiation effects*; D013997:Time Factors
D000970:Antineoplastic Agents; D011868:Radioisotopes; D003300:Copper