5-S-cysteinyldopa in the plasma of melanoma patients and the renal clearance of this amino acid.
5-S-cysteinyldopa has been demonstrated in the plasma of two patients with metastases of malignant melanoma and a high excretion rate of 5-S-cysteinyldopa in the urine. In one patient the plasma clearance of 5-S-cysteinyl dopa was 30 ml/min and in the other 69 ml/min. These clearance values were 43 and 45%, respectively, of the creatinine clearance in the two patients.
D000328:Adult; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003545:Cysteine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004295:Dihydroxyphenylalanine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008297:Male; D008545:Melanoma / Q000097:blood / Q000378:metabolism* / Q000652:urine; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000097:blood / Q000378:metabolism / Q000652:urine
D004295:Dihydroxyphenylalanine; D003545:Cysteine