Cross reactivity of human beta2-microglobulin with human granulocyte colony-stimulating activity.
Effects of antisera to human beta2-microglobulin (beta2 m) on factors able to stimulate colony formation in culture by human granulopoietic progenitor cells were investigated. The colony-stimulating activity (CSA) present in media conditioned by cultures of human peripheral leukocytes was suppressed by treatment with anti-beta2m. This inhibition was not due to a direct effect on the granulopietic progenitor cells; controls to test for cytotoxicity and for noncytotoxic inhibition of the progenitor cells by anti-beta2m yielded negative results. These experiments provide evidence for a relationship between human CSA and beta-microglobulin, and suggest a possible analogy between molceules involved in the in vitro regulation of granulopoiesis and products of the major histocompatibility gene complex.
D000818:Animals; D001609:Beta-Globulins / Q000276:immunology*; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000276:immunology*; D003429:Cross Reactions; D006023:Glycoproteins / Q000276:immunology*; D006041:Goats / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006410:Hematopoiesis; D006649:Histocompatibility Antigens; D006801:Humans; D007106:Immune Sera; D007962:Leukocytes / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology*
D001609:Beta-Globulins; D003115:Colony-Stimulating Factors; D006023:Glycoproteins; D006649:Histocompatibility Antigens; D007106:Immune Sera; D001613:beta 2-Microglobulin