[The stimulant effect of neuroleptics: myth or reality?].
On the basis of clinical observations and animal pharmacology, the hypothesis of two types of neuroleptics may be considered. Some neuroleptics ("monopolars") are always sedatives, whatever will be the dosage used practically. Other neuroleptics ("bipolars") would be stimulating at a low dosage and sedatives at a high dosage. Stimulation and sedation would be in relation with pre- and post-synaptic dopaminergic receptors blockade.
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D000697:Central Nervous System Stimulants; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006993:Hypnotics and Sedatives; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D001058:Apomorphine
L'effet stimulant des neuroleptiques: mythe ou réalité?