Isolation of influenza virus from liver and muscle biopsy specimens from a surviving case of Reye's syndrome.
Influenza virus (A/Ohio/7/76) was demonstrated by haemagglutination and by direct electron microscopy in chick embryo fluids inoculated with liver, muscle, cerebrospinal fluid, and nasotracheal secretions obtained from a boy with Reye's syndrome, 8 days after the onset of the upper-respiratory-tract symptoms and at the height of neurological and hepatic involvement. This finding accords with the hypothesis that Reye's syndrome may be an epiphenomenon of influenza-virus infection. It is postulated that the pathogenesis of Reye's syndrome may be related to the other influenzal eipiphenomena including influenzal pneumonia in previously healthy persons and influenza-associated myopathy, both of which, like Reye's syndrome, become clinically evident about 7 days after the first clinical signs of influenza.
D001927:Brain Diseases / Q000209:etiology*; D002675:Child, Preschool; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications / Q000382:microbiology; D008099:Liver / Q000382:microbiology*; D008297:Male; D009132:Muscles / Q000382:microbiology*; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D012202:Reye Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D013997:Time Factors