title: Factors influencing the distribution of 99m-technetium methylene diphosphonate in bone and soft tissues.
abstract: The influences of dilution, storage and pH on the distribution of 99m-technetium methylene diphosphonate (99m-Tc-MDP) in bone and various soft tissues have been investigated in the rat. The results show a marked departure from normality when large dilution factors and very acidic or basic preparations are used.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D004164:Diphosphonates / Q000378:metabolism; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium; D014018:Tissue Distribution
chemical_list: D004164:Diphosphonates; D013667:Technetium