Autoantibodies to Tamm-Horsfall protein, a tool for diagnosing the level of urinary-tract infection.
In sera from ten girls with acute pyelonephritis, antibodies of the IgG-class to Tamm-Horsfall protein were found in significantly increased titres; in contrast, titres in sera from six girls with acute cystitis did not differ from those of healthy controls. The results suggest that determination of Tamm-Horsfall antibodies may prove useful for differentiating between upper and lower urinary-tract infection.
D000208:Acute Disease; D000293:Adolescent; D000367:Age Factors; D001323:Autoantibodies / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007668:Kidney / Q000276:immunology; D009088:Mucoproteins / Q000276:immunology*; D011704:Pyelonephritis / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009088:Mucoproteins