title: Association and linkage between alcoholism and eleven serological markers.
abstract: Sera from alcoholics and their nonalcoholic first-degree relatives were analyzed for 11 serological markers. A lower prevalence of the S antigen in the nonalcoholic relatives and linkage in repulsion between the D gene of the Rh system and alcoholism were found. All the alcoholics and the relatives had an SS phenotype, when analyzed for complement C3, compared with a prevalence rate of about 50% in other studies. The first two associations involve blood groups, the latter a serum protein.
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood* / Q000235:genetics; D000941:Antigens / Q000032:analysis; D001789:Blood Group Antigens; D001798:Blood Proteins / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D012204:Rh-Hr Blood-Group System; D000515:alpha 1-Antitrypsin / Q000032:analysis; D005719:gamma-Globulins / Q000032:analysis
chemical_list: D000017:ABO Blood-Group System; D000941:Antigens; D001789:Blood Group Antigens; D001798:Blood Proteins; D003176:Complement C3; D006242:Haptoglobins; D012204:Rh-Hr Blood-Group System; D000515:alpha 1-Antitrypsin; D005719:gamma-Globulins