Anti-basement membrane antibodies in sera from patients without bullous pemphigoid.
Sera from 208 individuals were examined for antibasement membrane (anti-BM) antibodies by means of an indirect immunofluorescence technique. In sera from patients with bullous pemphigoid 19 of 25 had anti-BM antibodies in titres varying from 80 to 32 000. In 2 of 42 sera from patients with psoriasis, anti-BM antibodies were demonstrated (titres 40-640). Of 58 sera from patients with leg ulcers, antibodies were found in 4 (titres 40-320). Antibodies were found in 2 of 43 patients with cardio-vascular disease (titre 80) and in 1 of 40 control persons (titre 40). Serum from one of the patients with leg ulcers caused a punctate staining pattern unlike the tubular pattern seen in all other positive sera.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000918:Antibody Specificity; D001485:Basement Membrane / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007871:Leg Ulcer / Q000276:immunology; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G