The uptake of choline by Streptococcus pneumoniae.
Uptake of choline, a structural component of pneumococcal C- and F-teichoic acids, into bacteria growing in a defined medium was very efficient with an uptake constant ([S]10 5) of 3.2 microns. It was inhibited by iodoacetate, dinitrophenol and oligomycin but not by structural analogues of choline. Ethanolamine, however, was transported in the absence of choline but with a reduced affinity ([S]0.5 71.4 microns). The same constitutive system was probably used by both ethanolamine and choline. It is suggested that this system required ATP and probably involved choline kinase.
D000963:Antimetabolites / Q000494:pharmacology; D001692:Biological Transport; D002794:Choline / Q000378:metabolism*; D004983:Ethanolamines / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000378:metabolism*
D000963:Antimetabolites; D004983:Ethanolamines; D002794:Choline