title: On the possible mechanism of cyanoacrylate histotoxicity.
abstract: The loss of tissue fluid as a possible mechanism of cyanoacrylate histotoxicity was studied in vitro. There appears to be no statistical difference in the rates of fluid removal between methyl, isobutyl and N-octyl 2-cyanoacrylates, nor is there any correlation between fluid removed and the observed in vivo tissue damage. It is suggested that tissue fluids play a dual role in initiating polymerization and in polymer degradation; and that tissue damage depends upon the rate of polymer decomposition with the formation of toxic degradation products.
mesh_terms: D000704:Analysis of Variance; D002478:Cells, Cultured; D003487:Cyanoacrylates / Q000032:analysis / Q000633:toxicity*; D005110:Extracellular Space / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D013053:Spectrophotometry; D013194:Staining and Labeling; D014867:Water / Q000378:metabolism*
chemical_list: D003487:Cyanoacrylates; D014867:Water