Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids.
Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002540:Cerebral Cortex / Q000201:enzymology*; D003902:Detergents; D004789:Enzyme Activation / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D013574:Synaptosomes / Q000201:enzymology
D003902:Detergents; D008563:Membrane Lipids; D010743:Phospholipids; D011506:Proteins; D010740:Phospholipases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D002118:Calcium