title: The effect of disodium 5-ribonucleotide on reproductive function over three generations in the rat.
abstract: Deitary levels of 0.1, 1.0 and 2.0% disodium 5-ribonucleotide were administered to rats of the CD strain over 3 generations, and the growth and reproductive performance were compared with those of a control group. Treatment did not appear to affect parent animals, as assessed by the incidence of mortality, bodyweight change, food consumption, mating performance, Pregnancy rate, Gestation Peroid, and post-mortem findings. Total litter loss, Litter size, Litter and mean pup weights, pup mortality and the incidence of skeletal or other variants in the offspring were unaffected by treatment at any dosage level. Additional organ weight analysis and skeletal staining of 10 males and 10 females from all groups, and the histological examination of 10 male and 10 females  of the control and 2.0% level groups of the third generation did not provide any evidence of effects that could be related to treatment.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000473:pathology; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005313:Fetal Death / Q000139:chemically induced; D005421:Flavoring Agents / Q000494:pharmacology*; D005865:Gestational Age; D006150:Guanine Nucleotides / Q000494:pharmacology*; D007292:Inosine Nucleotides / Q000494:pharmacology*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D005421:Flavoring Agents; D006150:Guanine Nucleotides; D007292:Inosine Nucleotides