Prenatal detection of neural tube defects. Comparison between alpha-fetoprotein and beta-trace protein assays.
The prenatal diagnosis of neural tube defects is now possible in about 90 per cent of cases by assaying the amniotic fluid for alpha fetoprotein. The accuracy of beta-trace protein assays on amniotic fluid samples from defective fetuses was compared to alpha-fetoprotein studies. At present, alpha-fetoprotein studies provide more reliable results.
D000653:Amniotic Fluid / Q000032:analysis; D000757:Anencephaly / Q000175:diagnosis; D001609:Beta-Globulins / Q000032:analysis*; D002490:Central Nervous System / Q000002:abnormalities* / Q000196:embryology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D000013:Congenital Abnormalities / Q000175:diagnosis; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016135:Spinal Dysraphism / Q000175:diagnosis; D000509:alpha-Fetoproteins / Q000032:analysis*
D001609:Beta-Globulins; D002556:Cerebrospinal Fluid Proteins; D005326:Fetal Proteins; D000509:alpha-Fetoproteins