Treatment of small-cell carcinoma of bronchus.
A randomised trial comparing radiotherapy with a multiple chemotherapy regimen in 68 patients with small cell carcinoma of bronchus is reported. Although overall survival was  poor, radiotherapy resulted in significantly longer survival, better amelioration of symptoms, and less  side-effects than chemotherapy. Patients achieving  complete or partial remission on radiotherapy relapsed mainly with extrathoracic disease, in contradistinction  to those treated with chemotherapy whose thoracic disease recurred.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D013997:Time Factors; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D011344:Procarbazine; D014747:Vinblastine; D011239:Prednisolone