[Effect of benemycin and sodium succinate on metabolism of protons in mitochondria of guinea pig lung and liver tissues].
The data of studies on proton metabolism in mitochondria of the guinea pig lungs and liver with application of benemycin and sodium succinate show that benemycin does not affect the metabolism of protons in the lungs and liver mitochondria. Sodium succinate activates the release of protons from the lungs and liver mitochondria in state 4 according to Chance. When using sodium succinate for reducing the effect of benemycin on theorganism it is found that sodium succinate inhibits the utilization of protons of the lungs and liver mitochondria in state 3 according to Chance and activates this release in state 4, thus favouring an increase in their concentration in the extra-mitochondrial space. Sodium succinate increases survival rate of animals which were administered benemycin to.
D000818:Animals; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008168:Lung / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D013386:Succinates / Q000494:pharmacology*
D000904:Antibiotics, Antitubercular; D013386:Succinates
Vliianie benemitsina i suktsinata natriia na obmen protonov v mitokhondriiakh tkaneĭ legkikh i pecheni morskikh svinok.