[In vivo study of the hypocalcemic, hypophosphoremic, hyperlipemic, and immunogenic activities of the oligopeptide fragment common to ACTH, alpha and beta MSH, and beta lipotropin].
The intravenous injection that was given to rabbits which consisted of 0,5 mg of a common heptapeptide to ACTH4-10, BETA MSH11-17 hormones, and to beta lipotropic47-53 hormone (beta LPH47-53) was followed at the end of an hour by an augmentation of 70% of total lipids, and at the end of two hours by a lowering of calcemia (around 27%) and of phosphoremia (20%). The injection of a tetrapeptide corresponding to only ACTH7-10 bound to a nitrobenzylhydralamin and in presence of a Freund adjuvants has provoked the formation of corresponding antibodies.
D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000276:immunology / Q000494:pharmacology*; D000818:Animals; D001681:Biological Assay; D003429:Cross Reactions; D000939:Epitopes; D006949:Hyperlipidemias / Q000209:etiology; D006996:Hypocalcemia / Q000209:etiology; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis / Q000276:immunology / Q000494:pharmacology*; D009842:Oligopeptides / Q000276:immunology / Q000494:pharmacology; D010446:Peptide Fragments; D010758:Phosphorus / Q000097:blood; D011817:Rabbits; D013329:Structure-Activity Relationship; D013997:Time Factors; D008083:beta-Lipotropin / Q000032:analysis / Q000276:immunology / Q000494:pharmacology*
D000939:Epitopes; D009842:Oligopeptides; D010446:Peptide Fragments; D010758:Phosphorus; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin
Etude in vivo de l'activité hypocalcémiante, hypophosphorémiante, hyperlipémiante et immunogène de tronçons peptidiques communs aux hormones ACTH, alpha et beta MSH et hormone beta lipotropique