Effect of gonadotropins and prostaglandin on 3' : 5'-cyclic AMP synthesis in young rat testis.
Formation of cAMP has been studied in neonatal rat testis. In the presence of aminoophylline, LH and PGE1 stimulated cAMP levels during the entire postnatal period. The highest stimulation was found in the testis of 2-day-old rats after-which cAMP synthesis diminished with advancing age. FSH had no stimulatory effect on cAMP level in 5-day-old rats.
D000367:Age Factors; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D000242:Cyclic AMP / Q000096:biosynthesis*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*
D011458:Prostaglandins E; D000628:Aminophylline; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP