title: Changes in heart rate during administration of local anesthetics in neuropsychiatric patients.
abstract: The effects on heart rate of injections of local anesthetics into the oral mucosa were studied in neuropsychiatric patients; these patients, in whom syncope had not occurred, had been hospitalized for a prolonged period. The heart rate in the neuropsychiatric patients decreased by only 3.9% in contrast to an average decrease of 12.6% in healthy adults. Diazepam was also effective in reducing the cardiac response. The lack of responsiveness in the trigeminal-vagal reflex may be a factor in protecting patients from syncope.
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D005881:Gingiva; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011187:Posture; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D013575:Syncope / Q000139:chemically induced
chemical_list: D014151:Anti-Anxiety Agents; D008012:Lidocaine; D003975:Diazepam