Identification of an NAD(P)+-dependent 'malic' enzyme in small-intestinal-mucosal mitochondria.
An NAD(P)+-dependent 'malic' enzyme is shown to be present in mitochondria from small-intestinal mucosa. The intracellular location, activity and regulatory kinetic properties of the enzyme suggest that it participates in the major energy-producing pathway for net oxidation of glutamine-derived tricarboxylic acid-cycle intermediates.
D000818:Animals; D002417:Cattle; D002645:Chickens; D004285:Dogs; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D007700:Kinetics; D008291:Malate Dehydrogenase / Q000302:isolation & purification*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009243:NAD; D009249:NADP; D051381:Rats
D009243:NAD; D009249:NADP; D008291:Malate Dehydrogenase