title: [Specific binding of perazine, a piperazine side-chain phenothiazine drug, to a serum protein (author's transl)].
abstract: A binding of perazine to a serum protein of 48 000 D was determined by gel filtration. The affinity constant of the perazine-protein complex was found to be 5.42 X 10(6) mol/l corresponding to a specific binding of 70 ng/ml serum. This result may gather clinical relevance with regard to the "CNS-bioavailability" and individual response to perazine, the average therapeutic serum concentrations having been shown to range between appr. 50 and 200 ng/ml serum. A specific binding of perazine to human or bovine albumine could not be detected.
mesh_terms: D014150:Antipsychotic Agents / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D006801:Humans; D007525:Isoelectric Focusing; D010464:Perazine / Q000097:blood*; D011485:Protein Binding
chemical_list: D014150:Antipsychotic Agents; D001798:Blood Proteins; D010464:Perazine
vernacular_title: Eine spezifische Serumproteinbindung des Neuroleptikums Perazin.