Bordetella pertussis does not induce beta-adrenergic blockade.
Bordetella pertussis organisms induce histamine sensitivity and diminish the normal hyperglycemic response to epinephrine in experimental animals. These effects have been attributed to beta-adrenergic blockade. However, under conditions in which the decrease in epinephrine-induced hyperglycemia after B. pertussis administration was demonstrable, there was no change in rat reticulocyte beta-adrenergic receptor number or affinity measured by iodohydroxybenzylpindolol binding or in isoproterenol-stimulated adenylate cyclase activity. Therefore, there was no generalized beta-adrenergic blockade induced by B. pertussis. The observed effects can be explained by the hypersecretion of insulin resulting from B. pertussis administration.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000319:Adrenergic beta-Antagonists; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010567:Pertussis Vaccine / Q000494:pharmacology*; D051381:Rats; D012156:Reticulocytes / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D007328:Insulin; D010567:Pertussis Vaccine; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D004837:Epinephrine