Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative.
The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence of a metabolic activation system while (II) was highly mutagenic when tested directly. This is the first report on the conversion of a non-mutagenic N-nitrosamine to a mutagen by the formation of an alpha-acetoxy derivative.
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D001711:Biotransformation; D004353:Drug Evaluation, Preclinical / Q000379:methods; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
D001593:Benzyl Compounds; D009153:Mutagens; D009602:Nitrosamines; D009249:NADP; C015395:N-nitrosodibenzylamine