The interaction of central acting drugs with glutamate dehydrogenase.
The neuroleptics chlorpromazine, fluphenazine, triflupromazine and thioridazine seem to effect the aggregation of glutamate dehydrogenase by binding to one single site of the polypeptide chain, possibly the GTP site. This interaction could biologically be of importance for the degree of activity at high enzyme concentrations found in vivo. Amitriptyline and fluorazepam also bind to a specific single site of the polypeptide chain without effecting the aggregation of the oligomers. Because of the rather low affinity of these sites the binding of these drugs in vivo does not seem to cause a concentrating effect in the mitochondria.
D000244:Adenosine Diphosphate / Q000378:metabolism; D014151:Anti-Anxiety Agents / Q000378:metabolism; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism; D014150:Antipsychotic Agents / Q000378:metabolism; D001569:Benzodiazepines; D001665:Binding Sites / Q000187:drug effects; D001667:Binding, Competitive; D002491:Central Nervous System Agents / Q000378:metabolism*; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D011485:Protein Binding
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D002491:Central Nervous System Agents; D009243:NAD; D001569:Benzodiazepines; D000244:Adenosine Diphosphate; D006160:Guanosine Triphosphate; D005969:Glutamate Dehydrogenase