Studies with Brugia pahangi 10. An attempt to demonstrate the sharing of antigenic determinants between the worm and its hosts.
Infective stage Brugia pahangi that were reared in Aedes aegypti survived equally well in cats that had previously been immunized against mosquito tissue and in a normal cat. The survival of third, fourth, juvenile, adult and microfilarial stages of B. pahangi that were recovered from cats was similar in jirds that had been immunized against cat antigens and in normal jirds. Host antigenic determinants were not detected on the surface of larvae in substantial amounts using fluorescent antibody techniques. It is unlikely that B. pahangi evades the immune response of its vertebrate hosts by masquerading as "self" behind host antigens.
D000330:Aedes / Q000469:parasitology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000941:Antigens / Q000032:analysis; D002009:Brugia / Q000276:immunology / Q000472:pathogenicity; D002415:Cats; D000939:Epitopes; D005368:Filariasis / Q000276:immunology* / Q000469:parasitology; D005455:Fluorescent Antibody Technique; D005849:Gerbillinae / Q000276:immunology; D007814:Larva; D013559:Symbiosis; D014774:Virulence
D000906:Antibodies; D000941:Antigens; D000939:Epitopes