Oncornaviral protein modulation in mouse uterine tissue by estrogen (38467).
Treatment of ovariectomized NIH Swiss mice with estrogens elevated the level of the murine leukemia virus group specific protein and the activity of an RNA-directed DNA polymerase in the uterus. The extent that these markers were raised was dependent on the relative biological potency of the estrogen and on the time interval following treatment. Increases in the levels of both viral marker proteins were evident within 24 hr of treatment and were highest at 48 hr. Subsequently, viral protein levels declined to pretreatment levels.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology; D005260:Female; D009052:Leukemia Virus, Murine / Q000378:metabolism*; D051379:Mice; D010053:Ovary; D012194:RNA-Directed DNA Polymerase / Q000096:biosynthesis*; D014599:Uterus / Q000378:metabolism* / Q000382:microbiology; D014764:Viral Proteins / Q000096:biosynthesis*
D000956:Antigens, Viral; D004967:Estrogens; D014764:Viral Proteins; D004970:Estrone; D004958:Estradiol; D012194:RNA-Directed DNA Polymerase; D004964:Estriol