title: Treatment of duodenal ulcer with cimetidine.
abstract: In a small open trial nineteen patients with active duodenal ulceration shown by fibreoptic endoscopy were treated with a 6-week course of cimetidine 1.6 g daily. Seventeen had healed ulcers on repeat endoscopy at 6 weeks. Seven of these have relapsed symptomatically within a month of withdrawal of cimetidine. No statistically significant change in the haemoglobin, white-blood-cell count, urea and electrolytes, or liver-function tests was associated with treatment. Plasma-creatinine showed a very small but significant rise but the mean level remained within the normal range. The significance of this is not clear.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000863:Antacids / Q000008:administration & dosage / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001792:Blood Platelets / Q000473:pathology; D002452:Cell Count; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000097:blood / Q000188:drug therapy*; D005500:Follow-Up Studies; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007958:Leukocyte Count; D007962:Leukocytes / Q000473:pathology; D014508:Urea / Q000097:blood
chemical_list: D000863:Antacids; D006146:Guanidines; D006454:Hemoglobins; D007093:Imidazoles; D014508:Urea; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase