title: Gastric excretion of intravenously administered meperidine in surgical patients.
abstract: We have demonstrated sequestration of unchanged meperidine in gastric juice of humans following intravenous administration. Concentrations attained were as great as 360 times plasma concentration. The drug was first detected between 5 and 15 minutes after administration. This phenomenon appears to be due to ionization and ion trapping of meperidine in gastric juice.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005750:Gastric Juice / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D008614:Meperidine / Q000008:administration & dosage* / Q000097:blood; D008875:Middle Aged; D009369:Neoplasms / Q000601:surgery*; D013997:Time Factors
chemical_list: D008614:Meperidine