[Monocyte function in chronic uremia (author's transl)].
Monocyte function studies in vitro have been performed in 21 patients with terminal, dialysis-treated uremia and, in parallel, in 21 healthy normal subjects. In uremia the attachment, spreading activity, and reduction of nitroblue tetrazolium were shown to be significantly enhanced, indicating a metabolic activation of the monocytes. The phagocytosis of IgG-coated red cells, however, was significantly impaired. A modification of the monocyte IgG-receptor in uremic conditions is supposed; its relevance for the immunosuppression in uremic states is discussed.
D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D008297:Male; D008858:Microscopy, Phase-Contrast; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis; D006435:Renal Dialysis; D013194:Staining and Labeling; D014511:Uremia / Q000276:immunology*
D007074:Immunoglobulin G
Zur Monocyten-Funktion bei Kranken mit terminaler Niereninsuffizienz