title: Neuromuscular blocking potency of fazadinium in man.
abstract: The study was designed to compare the recovery rates of fazadinium and four other commonly used competitive muscle relaxants in forty patients and eight volunteers. One-fifth to 1/10 of the clinical doses of the muscle relaxants were diluted in 20 ml of saline and injected intravenously at the wrist after inflation of a pneumatic tourniquet on the upper arm. After 3 min the tourniquet was released and the recovery time of twitch tension from 25 to 75% of the control determined. Evoked force of middle finger adduction was measured at a frequency of 0.2 Hz. The mean 25-75% recovery times of twitch tension for tubocurarine, pancuronium, alcuronium, gallamine and fazadinium were 14.20 +/- 1.42, 12.30 +/- 1.02, 10.12 +/- 0.77, 10.07 +/- 1.12 and 9.90 +/- 0.87 min, respectively. The authors conclude that the dissociation rate of fazadinum from the receptor of the motor endplate appears to be the fastest among the competitive muscle relaxants studied in man.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000443:Alcuronium / Q000494:pharmacology; D005260:Female; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D011726:Pyridinium Compounds; D010197:Pancuronium; D005703:Gallamine Triethiodide; D000443:Alcuronium; D014403:Tubocurarine