title: [Biogenic amines in endocrine cells producing polypeptide hormones. The APUD-cells (Pearse) (author's transl)].
abstract: APUD-cells (A = Amine, P = Pprecursor, U = Uptake, D = Decarboxylation) are endocrine cells with numerous common characteristics: 1. They produce polypeptide hormones of low molecular weight. 2. They possess specific 1-amino acid decarboxylases to synthesize catecholamines and/or 5-hydroxytryptamine from precursors. 3. A part of the APUD-cell family primarily accumulates biogenic amines within their cytoplasm. 4. All APUD-cells are rich in specific secretory granules that are the morphological substrate for most of their common features.--Enzyme histochemically the APUD-cells represent a rather heterogenous population. The capacity to take up biogenic amines from the blood is confined to a smaller numer of APUD-cells. The concept of the APUD-cells representing a peripheral neurosecretory system (Pearse und Polak, 1971) appears to be premature. It is probable that in several APUD-cells the accumulation of biogenic amines only constitutes a phenomenon without any physiological relevance which, notwithstanding, could explain pathological reactions of APUD-cells.
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000096:biosynthesis*; D002395:Catecholamines / Q000378:metabolism; D002838:Chromaffin System / Q000201:enzymology / Q000378:metabolism*; D004296:Dopa Decarboxylase; D004702:Endocrine Glands / Q000201:enzymology / Q000378:metabolism*; D005753:Gastric Mucosa / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000378:metabolism; D006168:Guinea Pigs; D006651:Histocytochemistry; D006728:Hormones / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000502:physiology; D051379:Mice; D008856:Microscopy, Fluorescence; D009490:Neurosecretory Systems / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D013194:Staining and Labeling
chemical_list: D001679:Biogenic Amines; D002395:Catecholamines; D005768:Gastrointestinal Hormones; D006728:Hormones; D004296:Dopa Decarboxylase
vernacular_title: Biogene Amine in Polypeptidhormon-bildenden Zellen. Due APUD-Zellen (Pearse)