Initial effect of injury on ketone bodies and other blood metabolites.
The arterial and venous concentrations of ketone bodies and other metabolites were measured in twelve adults, from 2 to 24 hours after injury. Two groups could be distinguished, with or without hyperketonaemia (defined as more than 0.2 mmol per litre) in the 2-hour blood-sample. In the hyperdetonaemic group the concentrations of alanine, pyruvate, and lactate and the urinary nitrogen excretion were lower throughout the first 24 hours than in the non-hyperdetonaemic group. These preliminary results indicate that hyperketonaemia after trauma is associated with decreased protein breakdown.
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001800:Blood Specimen Collection; D002940:Circadian Rhythm; D003124:Colorimetry; D006259:Craniocerebral Trauma / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000652:urine; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000652:urine; D005971:Glutamates / Q000097:blood*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood* / Q000378:metabolism; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000652:urine; D011773:Pyruvates / Q000097:blood*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005971:Glutamates; D007328:Insulin; D007657:Ketone Bodies; D007773:Lactates; D011773:Pyruvates; D013006:Growth Hormone; D009584:Nitrogen; D000409:Alanine