title: [Double blind randomized trial of metopimazine: for postoperative nausea and vomiting after cholecystectomy].
abstract: Eighty-four patients submitted to cholecystectomy were randomly assigned in a double-blind study either to an intravenous dose of 10 mg of metopimazine, three times D-1, for two days or to an identically administered placebo. A definite superiority of metopimazine as an anti-emetic drug was demonstrated. General acceptance was excellent, but arterial pressure might be looked over closely when metopimazine was administered intravenously immediately after a general anesthesia.
mesh_terms: D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007540:Isonipecotic Acids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*; D014839:Vomiting / Q000188:drug therapy*
chemical_list: D007540:Isonipecotic Acids; D010640:Phenothiazines
vernacular_title: Essai comparatif en double insu de la métopimazine: sur le syndrome émétique post-opératoire après cholécystectomie.