The inhibition of stearoyl-coenzyme A desaturase by phenyllactate and phenylpyruvate.
The inhibition of oleic acid from stearic acid was studied using a rat liver microsomal preparation. Phenyllactic acid and phenylpyruvic acid are partially inhibitory. The may be related to the low oleic acid to stearic acid ratios found in brains of phenylketonuric persons and experimentally phenylketonuric rats.
D000818:Animals; D044943:Fatty Acid Desaturases / Q000037:antagonists & inhibitors*; D007773:Lactates / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D010667:Phenylpyruvic Acids / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D051381:Rats; D013230:Stearoyl-CoA Desaturase / Q000037:antagonists & inhibitors*
D007773:Lactates; D010667:Phenylpyruvic Acids; D000644:Quaternary Ammonium Compounds; D044943:Fatty Acid Desaturases; D013230:Stearoyl-CoA Desaturase