title: [Neurohumoral shifts in brain tumor patients].
abstract: The metabolism of acetylcholine and sympatheticoadrenal substances was studied in patients with cerebral tumors. A significant increase in the content of acetylcholine in blood and cerebrospinal fluid with a simultaneous decrease in the content of inhibitors and sympatheticoadrenal substances were established. A direct dependence between the degree of intracranial hypertension and the level of acetylcholine in blood and cerebrospinal fluid was revealed. Disorders of the metabolism of biologically active substances and their role in the pathogenesis of edema of the brain substantiate pathogenetically the inclusion of cholinolytic and sympathicotonic drugs in the symptomatic treatment of patients with cerebral tumors.
mesh_terms: D000109:Acetylcholine / Q000097:blood / Q000134:cerebrospinal fluid; D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000134:cerebrospinal fluid; D010276:Parasympatholytics / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D018377:Neurotransmitter Agents; D010276:Parasympatholytics; D000109:Acetylcholine
vernacular_title: O neirogumoral'nykh sdvigakh u bol'nykh s opukholiami golovnogo mozga.