Enzyme inducation as a possible cause of increased serum-trigylcerides after oral contraceptives.
Serial studies on twenty patients before and during oral-contraceptive therapy demonstrated a significant positive association between serum gamma-glutamyl-transpeptidase (G.G.T.) activity and triglyceride concentrations, both of which rose after treatment. The association between serum G.G.T. and triglyceride, and their increase after treatment with oral contraceptives, may reflect hepatic microsomal enzyme induction of both the rate-limiting enzymes of triglyceride synthesis, and G.G.T.
D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D009644:Norgestrel / Q000009:adverse effects*; D013997:Time Factors; D014280:Triglycerides / Q000096:biosynthesis / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood* / Q000502:physiology
D003276:Contraceptives, Oral; D004338:Drug Combinations; D014280:Triglycerides; D009644:Norgestrel; D004997:Ethinyl Estradiol; D002784:Cholesterol; D005723:gamma-Glutamyltransferase