Prolonged delirium with propanolol.
Propanolol use can result in a severe toxic psychosis. In this case, mild perceptual errors progressed eventually to a severe confusional state over a period of 6 months. Life threatening cardiac symptoms forced the continuation of propanolol until the bundle of His was surgically severed. Despite the prolonged delirium, the patient showed complete clearing of sensorium within 2 weeks after cessation of the drug. The differential diagnosis of delirium in the cardiac patient needs to include consideration of propanolol use.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001307:Auditory Perception / Q000187:drug effects; D003693:Delirium / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000188:drug therapy; D009949:Orientation / Q000187:drug effects; D011433:Propranolol / Q000009:adverse effects* / Q000627:therapeutic use; D014796:Visual Perception / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D011433:Propranolol