[Serum levels of alpha-2-macroglobulin, ceruloplasmin, transferrin, alpha-1-antitrypsin and complement (beta-1-C) before and following 3- and 6-day injections of D-penicillamine in man].
The serum levels of alpha-1-antitrypsin, ceruloplasmin, transferrin, alpha-2-macroglobulin and complement (beta-1-C) were measured by the radioimmunodiffusion method of Mancini before treatment, after three days treatment with D-penicillamine (1,00 g. i. v. daily) and after treatment for 3 days with 2 x 1,00 g i. v. D-Penicillamine. The levels of alpha-2-macroglobulin, coeruloplasmin and transferrin dropped significantly after 3 days' treatment. Doubling the dosage for 3 days induced a further drop in transferrin and ceruloplasmin. The alpha-2-macroglobulin was not further influenced. The levels of alpha-1-antitrypsin and complement were not influenced by D-Penicillamine treatment.


BACKGROUND
D-penicillamine, alpha-1-Antitrypsin, alpha-2-macroglobulin, transferrin, ceruloplasmin, complement (beta-1-C).
D000328:Adult; D001769:Blood; D002570:Ceruloplasmin / Q000378:metabolism*; D003172:Complement C1 / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000188:drug therapy; D012737:Sex Factors; D014168:Transferrin / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D003172:Complement C1; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D003165:Complement System Proteins; D002570:Ceruloplasmin; D010396:Penicillamine
Serumspiegel von Alpha-2-Makroglobulin, Coeruloplasmin, Transferrin, Alpha-1-antitrypsin und Komplement (beta-1-C) vor und nach 3- und 6tägiger D-Penicillamininjektion beim Menschen