Salivary secretion evoked by H80/62, (+/-)-1-(4-hydroxyphenoxy)-3-isopropylamino-2-propranol, a new beta 1-selective adrenoceptor agonist.
H80/62, recently introduced as a beta 1-selective adrenoceptor agonist, caused a long-lasting flow of saliva from parotid and submaxillary glands of the rat. The effect of H80/62 was prevented by propranolol or a beta 1-selective blocker. The drug did not exert its effect via the sympathetic postganglionic nerves; and it was not taken up by the neuronal amine pump. Sympathetically decentralized or denervated glands acquired a supersensitivity of the postjunctional type to H80/62.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D010306:Parotid Gland / Q000378:metabolism; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013363:Submandibular Gland / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D011433:Propranolol