De novo Kaposi's sarcoma in renal transplantation. Case report and brief review.
This report describes a de novo development of Kaposi's sarcoma in a Puerto-Rician man 9 months after a cadaveric renal transplant. Progression of the disease was observed despite local irradiation, while the patient remained immunosuppressed with prednisone and azathioprine. This was accompanied by depressed immunologic tests. Discontinuation of azathioprine and addition of chemotherapy (bleomycin and vincristine), while continuing prednisone to maintain functional survival of renal allograft, has led in this patient to regression of extensive cutaneous and suspected pulmonary Kaposi's sarcoma lesions. The possible importance of a depressed immunosurveillance mechanism and activation of latent oncogenic virus by the presence of an allograft in the de novo appearance of Kaposi's sarcoma in transplant recipients is briefly discussed.
D000917:Antibody Formation; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications* / Q000628:therapy; D014184:Transplantation, Homologous; D014750:Vincristine / Q000627:therapeutic use
D001761:Bleomycin; D014750:Vincristine; D001379:Azathioprine