[Influence of hypertensive substances on the kallikrein-kinin system of the blood].
It is shown that following a one-time intravenous administration to rats of ethyron, epinephrine and pituitrin (in doses causing hypertension) the amount of the blood plasma kininogen is more than halved with concurrently increasing caseinolysis. A two-day long introduction of these substances activates prekallicrein and brings down the level of the kallicrein inhibitors, whereas a 10 and 20-day coursewise administration of these compounds intensifies the synthesis of some components in the kallicrein-kinine system.
D000818:Animals; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D007550:Isothiuronium / Q000031:analogs & derivatives; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000097:blood*; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000097:blood*; D008297:Male; D010909:Pituitary Hormones, Posterior / Q000008:administration & dosage / Q000494:pharmacology*; D010949:Plasma / Q000187:drug effects*; D011288:Prekallikrein / Q000097:blood; D051381:Rats; D013890:Thiourea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D007704:Kininogens; D007705:Kinins; D010909:Pituitary Hormones, Posterior; D007550:Isothiuronium; C007687:etiron; D011288:Prekallikrein; D007610:Kallikreins; D013890:Thiourea; D004837:Epinephrine
Vliianie gipertenzivnykh veshchestv na kallikrein-kininovuiu sistemu krovi