title: Detection of "alpha-type" inhibitors in the presence of low levels of specific influenza antibodies.
abstract: In native, heated or otherwise treated egg white and in sera of men and guinea pigs, haemagglutination inhibition titres were determined against three inhibitor-sensitive (IS) strains and one inhibitor-resistant (IR) variant on influenza A virus. A few human sera with no detectable antibody revealed high inhibition titres even against the IR variant. Human sera after treatment with trypsin and periodate revealed mostly a reduction or no change, and exceptionally an increase of their inhibition titre. The extent of these changes varied with different influenza virus strains and showed a positive correlation with the inhibitor content and no correlation with the antibody levels of the sera. The so-called "nonspecific" thermostable inhibitors possess a certain degree of specificity for different influenza virus strains.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000998:Antiviral Agents / Q000032:analysis*; D005260:Female; D014644:Genetic Variation; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D006358:Hot Temperature; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D008297:Male; D010504:Periodic Acid / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D010504:Periodic Acid; D014357:Trypsin