Antibiotics derived from a mutant of Bacillus circulans.
A mutant of Bacillus circulans, which produces butirosins only when 2-deoxystreptamine is added to the fermentation medium, was employed in the biosynthesis of antibiotics containing modified aminocyclitols. The blocked mutant converted 2,5-dideoxystreptamine into 5-deoxybutirosamine. Streptamine was incorporated into a complex differing from butirosin by an additional hydroryl at C-2.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D001407:Bacillus / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D002076:Butirosin Sulfate / Q000494:pharmacology; D005285:Fermentation; D006595:Hexosamines; D009154:Mutation
D000900:Anti-Bacterial Agents; D006595:Hexosamines; D002076:Butirosin Sulfate