title: Diagnosis of Hirschsprung's disease by quantitative biochemical assay of acetylcholinesterase in rectal tissue.
abstract: Acetylcholinesterase activity was measured in rectal-biopsy specimens obtained from nineteen children. Seven children in whom the diagnosis of Hirschsprung's disease was established were found to have a significantly higher enzyme activity than the twelve in whom this diagnosis was excluded. The estimation may prove to be of value in the diagnosis of Hirschsprung's disease.
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008531:Megacolon / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D012007:Rectum / Q000201:enzymology* / Q000473:pathology
chemical_list: D000110:Acetylcholinesterase