Responsiveness of the rabbit eye to adrenergic and cholinergic agonists after treatment with 6-hydroxydopamine or alpha-methyl-para-tyrosine: part II--intraocular pressure changes.
The influence of adrenergic and cholinergic drugs on intraocular pressure after chemical sympathectomy produced by 6-hydroxydopamine has been examined in rabbits. For comparison, ocular tension in response to these same drugs has been measured after chronic treatment of rabbits with the norepinephrine synthesis inhibitor alpha-methyl-para-tyrosine. The results indicated that the effects of these 2 treatments were both qualitatively and quantitatively similar. In both cases, supersensitivity to the pressure-lowering effects of alpha and beta adrenergic amines developed. After administration of cholinergic drugs, however, ocular tension became elevated to values ranging from 3 to 7 mm Hg above the baseline levels.
D000322:Adrenergic Agonists; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004456:Echothiophate Iodide / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects*
D000322:Adrenergic Agonists; D006892:Hydroxydopamines; D008781:Methyltyrosines; D010277:Parasympathomimetics; D002217:Carbachol; D004456:Echothiophate Iodide; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine