title: Hepatitis due to aflatoxicosis. An outbreak in Western India.
abstract: Parts of Western India have experienced an outbreak of hepatitis affecting man and dogs and characterised by jaundice, rapidly developing ascites, portal hypertension, and a high mortality-rate. The disease was associated with the consumption of maize contaminated heavily with Aspergillus flavus. Analysis of contaminated samples showed that affected people could have consumed between 2 and 6 mg. of aflatoxin daily over a period of a month. A specimen of liver obtained at necropsy showed bileduct proliferation and giant cells. The disease appears to be a result of aflatoxicosis.
mesh_terms: D000328:Adult; D000348:Aflatoxins / Q000009:adverse effects*; D000818:Animals; D001231:Aspergillus flavus; D001344:Autopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D002648:Child; D004196:Disease Outbreaks / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D005506:Food Contamination; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007194:India; D008099:Liver / Q000473:pathology; D008297:Male; D012423:Rural Health; D003313:Zea mays
chemical_list: D000348:Aflatoxins