Treatment of severe combined immunodeficiency with bone-marrow from an unrelated, mixed-leucocyte-culture-non-reactive donor.
A 7-month-old boy with severe combined immunodeficiency had no relative who was a suitable bone-marrow donor as determined by mixed-leucocyte-culture (M.L.C.) testing. In the general population an M.L.C.-nonreactive, unrelated donor was found among individuals who were identical with our patient at the Four locus. Following a bone-marrow transplant this child showed signs of rapid immunological reconstitution and only a mild graft-versus-host reaction. Unfortunately, the child died 31 days post-transplantation of cytomegalovirus infection. The findings support the hypothesis that matching for lymphocyte-defined antigens among unrelated individuals will permit successful immunological reconstitution.
D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D005500:Follow-Up Studies; D006087:Graft vs Host Reaction; D006680:HLA Antigens / Q000302:isolation & purification; D006650:Histocompatibility Testing; D006801:Humans; D007085:Ilium / Q000473:pathology; D007104:Immune Adherence Reaction; D007136:Immunoglobulins / Q000302:isolation & purification; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D066298:In Vitro Techniques; D007958:Leukocyte Count; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D014019:Tissue Donors; D014184:Transplantation, Homologous
D006680:HLA Antigens; D007136:Immunoglobulins