[The use of the cell separator in the treatment of leukemia].
In order to provide leukemic patients during the critical granulocytopenic stage with a sufficient amount of granulocytes a blood cell separator with a continuous extracorporeal circulation was developed. This permits to obtain up to 3.0-10(10) leukocytes during a 4---5 hours period from a single donor. According to our own experiences with 20 leukophereses performed in 13 healthy donors by the use of the AMINCO cell separator an average of 1.17-10(10) leukocytes with a granulocytic portion of 61% was collected per run. In two cases of agranulocytosis and septic fever (one case of pseudomonas septicaemia) the repeated administration of leukocyte concentrates, while specific antibiotic therapy was continued, led to a marked improvement over a longer period of time. Furthermore thrombocyte concentrates up to 7.0-10(10) platelets can be obtained by the cell separator. Applied as depletory method in the treatment of CML and CLL leukopheresis may rapidly diminish the peripheral leucocyte count while spleen and lymphomas decrease in size at the same time. A 20% reduction in cell count may be achieved by a serie of 3---4 leukophereses. Also the use of the cell separator in the treatment of makroglobulinemia by plasmapheresis is discussed.
D000293:Adolescent; D001803:Blood Transfusion; D002469:Cell Separation / Q000295:instrumentation; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D037102:Lectins; D007938:Leukemia / Q000628:therapy*; D007945:Leukemia, Lymphoid / Q000628:therapy; D007951:Leukemia, Myeloid / Q000628:therapy; D007962:Leukocytes; D008213:Lymphocyte Activation; D008297:Male; D010956:Plasmapheresis / Q000295:instrumentation*; D013163:Splenomegaly / Q000628:therapy
D037102:Lectins
Der Einsatz des Zellseparators in der Leukämiebehandlung