Studies on the inhibition of adrenaline-induced aggregation of blood platelets.
alpha-Adrenoceptors of platelets seem to differ from those of other cell types. The inhibitory effect of alpha-adrenoceptor-blocking agents on adrenaline-induced aggregation of human platelets does not parallel that on adrenaline-induced contraction of rabbit aortic strips. The most potent inhibitors of adrenaline-induced platelet aggregation are the dihydrogenated ergot alkaloids of the peptide type. Among the other ergoline derivatives testes, only lisuride has a stronger inhibitory effect than those of natural ergot alkaloids.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004876:Ergot Alkaloids / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D000317:Adrenergic alpha-Antagonists; D004876:Ergot Alkaloids; D004837:Epinephrine