Adrenergic- and cyclic nucleotide-induced glycerol release from brown adipocytes.
Previous work has shown that although both alpha- and beta-agonists stimulate brown fat heat production, the beta agonist is quantitatively more effective. The finding in the present study that isoproterenol, a beta-agonist, significantly stimulates net glycerol release from isolated hamster brown adipocytes while the alpha-agonist, phenylephrine does not, may account (at least in part) for the differential thermogenic response to the two types of agents. The present study also compared lipolytic responses to AMP, cAMP, cGMP and theophylline, with the results indicating a greater rate of net glycerol release being induced by AMP and by cAMP than by theophylline or cGMP plus theophylline.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D010656:Phenylephrine / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D010656:Phenylephrine; D000249:Adenosine Monophosphate; D013806:Theophylline; D000242:Cyclic AMP; D006152:Cyclic GMP; D007545:Isoproterenol; D005990:Glycerol