Sulphasalazine treatment during breast feeding.
The steady-state concentrations of sulphasalazine and sulphapyridine in serum and mother's milk have been measured in 12 nursing patients who were being treated with sulphasalazine. The results show that sulphasalazine passes only in negligible amounts or not at all into milk. The concentration of sulphapyridine in milk was about 40% of the serum concentration in the mother. We therefore conclude that sulphasalazine may safely be given during nursing.
D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D005260:Female; D006801:Humans; D007774:Lactation; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy; D013427:Sulfapyridine / Q000097:blood / Q000378:metabolism; D012460:Sulfasalazine / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use
D012460:Sulfasalazine; D013427:Sulfapyridine