title: Histochemical studies of some hepatic enzyme activities in rat during extrahepatic common bile duct obstruction.
abstract: Studies on some enzyme activities as measured histochemically in the ligated common bile duct rat liver are reported. They show principally: an increased GGT reaction in the neoductular cells; a diffusion of the LAP reaction to the neoductuli; an immediate increase and diffusion of the alkaline phosphatase reaction; an increase of G-6-PA and AMPA reactions; an increase, during the first week, of the Phyla activity and a contemporary decrease of the UDPG-GS reaction. No significant changes have been observed in other enzyme activities. By means of some dehydrogenase reactions, morphological evidence that the hepatocytes may be involved in neoductular cells formation was obtained.
mesh_terms: D000249:Adenosine Monophosphate; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000201:enzymology*; D003137:Common Bile Duct Diseases / Q000201:enzymology*; D005952:Glucose-6-Phosphatase / Q000032:analysis; D006006:Glycogen Synthase / Q000032:analysis; D006651:Histocytochemistry; D007931:Leucyl Aminopeptidase / Q000032:analysis; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008297:Male; D009708:Nucleotidases / Q000032:analysis; D006005:Phosphorylases / Q000032:analysis; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000032:analysis
chemical_list: D000249:Adenosine Monophosphate; D005723:gamma-Glutamyltransferase; D006005:Phosphorylases; D006006:Glycogen Synthase; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D005952:Glucose-6-Phosphatase; D007931:Leucyl Aminopeptidase