[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine].
The authors made a study of the antihistaminic properties of Pipoxizine in 20 subjects with proven histaminic hyperreactivity. The design of the trial consisted in comparing the changes of VC, FEC1, expiratory airway resistance and V50 produced by a histamine aerosol given before and after administration of Pipoxizine. Pipoxizine was given by mouth to 10 patients and intravenously to the other 10 of the group. The statistical analysis of the results demonstrated an antagonist effect of Pipoxizine on the histamine induced bronchoconstriction. The data of this trial are confirmative of the results of other experimenters. It seems therefore reasonable to take into consideration the use of Pipoxizine in the preventive treatment of the paroxystic attacks of the asthmatic disease.
D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects; D000609:Aminoacridines / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy; D005541:Forced Expiratory Volume; D006632:Histamine / Q000008:administration & dosage*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008875:Middle Aged; D014797:Vital Capacity / Q000187:drug effects
D000336:Aerosols; D000609:Aminoacridines; D006634:Histamine H1 Antagonists; C010814:C 325; D006632:Histamine
Action d'un aérosol d'histamine chez 20 sujets ayant une hyperréactivité histaminique. Application à l'étude de l'effect protecteur de la Pipoxizine.