[Effect of cromoglicinic acid on the degranulation of mast cells (author's transl)].
An interference microscopic method is described which allows quantitative measurements of the inhibiting effect of the di-sodium salt of 1,3-bis(3-carboxy-chroman-5-yl-oxy)-2-hydroxypropand (cromoglicinic acid; Intal; DSCG) on the degranulation of mast cells in vitro induced by polymixin B and Compound 48/80. The specific degranulation inhibiting effect of DSCG is increased in the presence of Ca++ and Mg++ ions.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects*; D009921:Metaproterenol / Q000494:pharmacology; D011113:Polymyxins / Q000037:antagonists & inhibitors; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors
D011113:Polymyxins; D003189:p-Methoxy-N-methylphenethylamine; D009921:Metaproterenol; D011433:Propranolol; D008274:Magnesium; D007545:Isoproterenol; D004205:Cromolyn Sodium; D002118:Calcium
Zur Wirkung der Cromoglicinsäure auf die Degranulation von Mastzellen