[Effect of transmembrane potential on noradrenaline transport in chromaffin granules].
Imposing a transmembrane potential positive with respect to the medium on chromaffin granule ghosts increased the initial rate of the delta pH-induced uptake of noradrenaline, whereas imposing a negative potential decreased this rate. The increase of the uptake rate was proportional to the potential. The ATP-induced uptake of noradrenaline was also sensitive to the potential since imposing a transient negative potential onto the positive potential generated by the membrane ATPase induced a latency in this transport.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002417:Cattle; D002837:Chromaffin Granules / Q000187:drug effects / Q000378:metabolism*; D002838:Chromaffin System / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D014634:Valinomycin / Q000494:pharmacology
D014634:Valinomycin; D011188:Potassium; D009638:Norepinephrine
Effet du potential transmembranaire sur le transport de la noradrénaline par les granules chromaffines.