An in vitro rat liver microsomal system for conjugating fatty acids to 11-hydroxy-delta 9-tetrahydrocannabinol.
We have previously identified long-retained metabolites of delta 9-tetrahydrocannabinol (delta 9-THC) and delta 8-tetrahydrocannabinol (delta 8-THC) in the rat as fatty acid conjugates of 11-hydroxy-delta 9-THC and 11-hydroxy-delta 8-THC. These metabolites can be produced in vitro using a rat liver microsomal energy-dependent esterase system.
D000818:Animals; D002855:Chromatography, Thin Layer; D003067:Coenzymes / Q000378:metabolism; D013759:Dronabinol / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
D003067:Coenzymes; D005227:Fatty Acids; D013759:Dronabinol