Prevention of vitamin-D deficiency in Asians.
Asian families living in Glasgow were studied between December, 1973, and June, 1974. One group of families served as a control; their mean serum-25-hydroxy-vitamin-D (25-hydroxy-cholecalciferol and 25-hydroxyergocalciferol) remained low, being 5-1 +/- 0-8 (S.E.M.) ng/ml at the end of the study. A second group was given 3000 units of vitamin D2 in a capsule weekly; this raised the mean concentration of 25-hydroxy-vitamin-D to 18-1 +/- 2-9 ng/ml. The variable effectiveness of this supplement was attributable to some subjects not taking the capsules regularly. The third group of families was provided with chupatty flour fortified with vitamin D(6000 units per kg). This increased mean serum-25-hydroxy-vitamin-D very uniformly to a mean value of 19-5 +/- 1-2 ng/ml. It is concluded that vitamin-D deficiency in Asian immigrants could be substantially reduced by fortification of chupatty flour with vitamin D.
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001208:Asia / Q000208:ethnology; D002118:Calcium / Q000097:blood; D002648:Child; D004872:Ergocalciferols / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use; D005433:Flour; D005500:Follow-Up Studies; D005527:Food, Fortified; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D010710:Phosphates / Q000097:blood; D012606:Scotland; D013997:Time Factors; D014808:Vitamin D Deficiency / Q000097:blood / Q000178:diet therapy / Q000517:prevention & control*
D004872:Ergocalciferols; D006887:Hydroxycholecalciferols; D010710:Phosphates; D000469:Alkaline Phosphatase; D002118:Calcium