Biotransformation of mazindol. II. Absorption and excretion in the dog and man.
On administration of tritium-labeled mazindol (l) to man and the dog, absorption was slow but complete. Excretion was slow in both dog and man, but the dog did excrete the drug and/or metabolites faster than man. Blood levels of l in man after a single oral dose of a 2-mg tablet reached a peak value of 2.5 ng/ml, which remained essentially unchanged for at least 6 hr. After multiple doses of a 2-mg tablet t.i.d. for 4 days to subjects who had been receiving nonlabeled l, 2 mg t.i.d. for 6 months, the blood level reached a maximum concentration of 10.8 ng/ml, measured 2 hr after the last dose on day 4. This value is somewhat higher than predicted by the single-dose data, indicating that in man, mazindol does not induce its own metabolism.
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D006801:Humans; D007211:Indoles / Q000378:metabolism*; D008454:Mazindol / Q000378:metabolism*; D013997:Time Factors
D007211:Indoles; D008454:Mazindol