title: The protection of primates against soman poisoning by pretreatment with pyridostigmine.
abstract: The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. The protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002143:Callitrichinae; D002802:Cholinesterases / Q000097:blood; D005260:Female; D000882:Haplorhini; D007928:Lethal Dose 50; D008253:Macaca mulatta; D008297:Male; D062025:Organophosphate Poisoning; D011729:Pyridostigmine Bromide / Q000627:therapeutic use*; D012999:Soman / Q000506:poisoning* / Q000633:toxicity; D013997:Time Factors
chemical_list: D001285:Atropine; D012999:Soman; D002802:Cholinesterases; D011729:Pyridostigmine Bromide