title: Evolution of biosynthetic pathways: immunological approach.
abstract: Through the use of specific immunoadsorbent columns, it is shown that Escherichia coli aspartokinase I-homoserine dehydrogenase I, aspartokinase II-homoserine dehydrogenase II, aspartokinase III, and homoserine kinase, enzymes involved in the same complex biosynthetic pathway, share antigenic determinants. This raises the question of a common origin for the four cibtenoirart kinases. (Aspartate kinase or ATP:L aspartate 4-phosphotransferase, EC 2.7.2.4; homoserine dehydrogenase or Lhomoserine:NADP oxidoreductase, EC 1.1.1.3; homoserine kinase or ATP:L-homoserine O-phosphotransferase, EC 2.7.1.39.)
mesh_terms: D000429:Alcohol Oxidoreductases / Q000276:immunology*; D000818:Animals; D000937:Antigen-Antibody Reactions; D001222:Aspartate Kinase / Q000276:immunology*; D005075:Biological Evolution; D000939:Epitopes; D004926:Escherichia coli / Q000201:enzymology* / Q000276:immunology; D006714:Homoserine; D006715:Homoserine Dehydrogenase / Q000276:immunology*; D007527:Isoenzymes / Q000032:analysis; D046911:Macromolecular Substances; D008970:Molecular Weight; D010770:Phosphotransferases / Q000276:immunology*; D017853:Phosphotransferases (Alcohol Group Acceptor); D011817:Rabbits / Q000276:immunology; D013912:Threonine / Q000096:biosynthesis*
chemical_list: D000939:Epitopes; D007527:Isoenzymes; D046911:Macromolecular Substances; D013912:Threonine; D006714:Homoserine; D000429:Alcohol Oxidoreductases; D006715:Homoserine Dehydrogenase; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C021370:homoserine kinase; D001222:Aspartate Kinase