The protective effect of some phenothiazine derivatives against streptolysin O.
1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004562:Electrocardiography; D006461:Hemolysis / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D010640:Phenothiazines; D013301:Streptolysins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013997:Time Factors
D014150:Antipsychotic Agents; D010640:Phenothiazines; D013301:Streptolysins