Preparation of cardioplegic solutions.
The manufacturing methods and quality control procedures for two cardioplegic solutions are described. Procedures for preparing individual bottles or batches of two cardioplegic solutions (one with and one without albumin) and a carbonate-bicarbonate buffer solution are described. Final buffered cardioplegic solutions with albumin are stable for seven days. Cardioplegic solutions without albumin and buffer are stable for 30 days. The chemical and physiological factors affecting the content and preparation of cardioplegic solutions used during intracardiac surgery are reviewed. Because consistency is attained more readily, and because control procedures, including quarantining, are applied more readily to batch production of cardioplegic solutions, it is advised that this method be used.
D000418:Albumins; D002245:Carbon Dioxide / Q000032:analysis; D004338:Drug Combinations; D004339:Drug Compounding; D006324:Heart Arrest, Induced; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009200:Myocardial Contraction / Q000187:drug effects*; D012996:Solutions / Q000032:analysis
D000418:Albumins; D004338:Drug Combinations; D012996:Solutions; D002245:Carbon Dioxide