title: [Thrombolysis: biochemical basis of fibrinolysis. Fibrinogen].
abstract: Fibrinogen is synthetised in the parenchymatous cells of the liver. It is broken down in the plasma by cells equipped with the appropriate enzymes. The fibrinogen molecule is a dimer with a molecular weight of 340,000. Each monomer consists of three polypeptidie chains (alpha A, beta B and gamma) joined by disulphide bridges. The N-terminal region is rigid and constitutes the N-DSK (N-disulphide knot) around which the three C-terminal free extremities are rolled, thereby giving a symmetry and spherical form to the molecule. The existence of several types of alpha A chains explains their important role in polymerisation.
mesh_terms: D000595:Amino Acid Sequence; D005340:Fibrinogen / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D008968:Molecular Conformation; D008970:Molecular Weight; D010446:Peptide Fragments
chemical_list: D010446:Peptide Fragments; D005340:Fibrinogen
vernacular_title: La thrombolyse: les bases biochimiques de la fibrinolyse. La fibrinogène.