Influence of immune status on virus-derived transplantable hepatoma in chickens.
The transplantable MC-29 virus-derived hepatoma is a suitable model for studying the influence of immune status on virus-derived hepatomas in chickens. It was found that both humoral and cellular immunologic reactions have a role in the pathogenesis of virus-derived hepatomas and that virus-derived hepatomas can be influenced by nonspecific immunostimulation. The lymphoid system was profoundly altered in hepatoma-bearing chickens; this cannot be neglected when studying correlations between immune reactions and carcinogenesis. Profound changes were also observed in protein synthesis and the steroid receptor system of hepatoma-bearing chickens compared to healthy birds; this also complicates the understanding of the role of immune mechanisms in carcinogenesis.
D000818:Animals; D001354:Avian Leukosis Virus; D001500:BCG Vaccine / Q000494:pharmacology; D002645:Chickens; D007109:Immunity; D007116:Immunization, Passive; D008114:Liver Neoplasms, Experimental / Q000276:immunology* / Q000378:metabolism; D008221:Lymphoid Tissue / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011987:Receptors, Steroid / Q000378:metabolism; D014412:Tumor Virus Infections / Q000276:immunology*; D014444:Tyrosine Transaminase / Q000096:biosynthesis
D001500:BCG Vaccine; D011987:Receptors, Steroid; D014444:Tyrosine Transaminase