Recent studies of psychophysiology in schizophrenia.
A general introduction is given and followed by a review of recent literature under the following subheadings: electrodermal activity, cardiovascular activity, smooth pursuit eye movement, electroencephalogram, and evoked potentials. An attempt is made to assess the clinical significance of the findings reported in each area and to indicate directions for future investigation. The feasibility of defining homogeneous subgroups in schizophrenia using psychophysiological parameters is also considered. The review concludes with the recommendation that peripheral psychophysiological studies entailing (1) comprehensive recording of brain electrical activity and (2) behavioral experimentation on variables thought to be influenced by schizophrenia (e.g., sustained attentional ability) are promising directions for future research. Relationships between behavioral and psychophysiological variables determined by such studies (and possibly subgroupings) may then become the basis for neurophysiological-neurochemical investigations of specific abnormalities underlying such relationships and subgroups.
D014150:Antipsychotic Agents / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005133:Eye Movements / Q000187:drug effects; D005712:Galvanic Skin Response / Q000187:drug effects / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D012025:Reflex, Pupillary; D012106:Research; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D012561:Schizophrenia, Childhood / Q000503:physiopathology
D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents