Catecholamine-mediated arrhythmias in acute myocardial infarction. Experimental evidence and role of beta-adrenoceptor blockade.
Ventricular fibrillation is a major mechanism of sudden death. The cellular link between catecholamine activity and the development of serious ventricular arrhythmias may be in the formation of cyclic adenosine monophosphate (cAMP). Cyclic AMP and agents promoting cAMP accumulation allow development of slow responses which, especially in the presence of regional ischaemia, could develop into ventricular fibrillation. The role of beta-antagonist agents in the therapy of acute myocardial infarction is analysed in relation to the hypothesis linking cAMP and ventricular fibrillation. Reasons for the limited effectiveness of anti-arrhythmic therapy with beta-antagonist agents are given.
D000319:Adrenergic beta-Antagonists / Q000502:physiology / Q000627:therapeutic use*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002395:Catecholamines / Q000502:physiology*; D002415:Cats; D003327:Coronary Disease / Q000503:physiopathology; D000242:Cyclic AMP / Q000502:physiology; D003864:Depression, Chemical; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D000882:Haplorhini; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D009206:Myocardium / Q000032:analysis; D010146:Pain / Q000188:drug therapy; D010215:Papio; D051381:Rats; D013268:Stimulation, Chemical; D013552:Swine; D013806:Theophylline / Q000494:pharmacology; D014693:Ventricular Fibrillation / Q000150:complications / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D013806:Theophylline; D000242:Cyclic AMP; D004837:Epinephrine