Immunosuppressive effects of sulfato-trans-(-)-1,2-diaminocyclohexaneplatinum(II).
Sulfato-trans-(-)-1,2-diaminocyclohexane platinum(II) is a new antitumor agent. Its effect on immune responses was investigated. This agent inhibited lymphocyte transformation in response to phytohemagglutinin, pokeweed mitogen, and concanavalin A. It inhibited antibody plaque-forming spleen cells in AKR/J mice at doses ranging from 2.5 to 7.5 mg/kg i.p. It also prolonged the survival of skin grafts against major histocompatibility barriers in C57BL/6J mice transplanted with tail skin from CBA/J mice. The effective dose ranged from 2.5 to 5 mg/kg. This compound inhibited graft-versus-host reaction in three-week-old AKR/J X DBA/2JF1 mice receiving spleen cells from AKR/J mice i.p. Significant inhibition of graft-versus-host reaction was seen with doses ranging from 1 to 7.5 mg/kg i.p. These results suggest that this drug is immunosuppressive.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D003510:Cyclohexanes; D004305:Dose-Response Relationship, Drug; D005260:Female; D006087:Graft vs Host Reaction; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000276:immunology; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D003510:Cyclohexanes; D008934:Mitogens; D009944:Organoplatinum Compounds