Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver.
Alpha-hexachlorocyclohexane (alpha-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two alpha-HCH dechlorinating enzymes at least; one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated with the formation of another hydrophilic product. This product is probably a conjugate of the alpha-HCH-residue with GSH. The other cytoplasmic alpha-HCH-dechlorinase requires no additions. The microsomes, too, contain two alpha-HC dechlorinases at least: one is stimulated by GSH, the other by NADPH.
D000096:Acetone; D000818:Animals; D001673:Biodegradation, Environmental; D002248:Carbon Monoxide / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008862:Microsomes, Liver / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013448:Sulfobromophthalein / Q000494:pharmacology
D013448:Sulfobromophthalein; D000096:Acetone; D009249:NADP; D001556:Hexachlorocyclohexane; D002248:Carbon Monoxide; D011335:Proadifen; D005978:Glutathione