Biochemical and behavioural studies on the interference between catecholaminergic and serotonergic central systems.
L-DOPA, apomorphine and amphetamine increase emotional reactivity and aggressiveness, and/or evoke spontaneous attack behaviour in male rats. At the same time these compounds accelerate the turnover of endogenous serotonin (5-HT), increasing the brain concentration of 5-HIAA. L-DOPA, amphetamine and apomorphine antagonize the depressive effects of 6-tryptophan on behaviour. After the injection of L-tryptophan these dopaminomimetics facilitate the turnover of 5-HT in the brain. On the other hand, the tranquillizing effect of L-tryptophan correlates not only to the increased level of 5-HT but also to an accelerated catabolism of dopamine. After the simultaneous injection of L-DOPA and L-tryptophan, cross-influence on the turnover of 5-HT and dopamine is noted, while in behaviour the effects of L-DOPA prevail over those of L-tryptophan. PCPA blocks the behavioural effects of dopaminomimetics.
D000316:Adrenergic alpha-Agonists / Q000378:metabolism; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005106:Exploratory Behavior / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D012701:Serotonin; D007980:Levodopa; D014364:Tryptophan; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine