Effect of pretreatment with local corticosteroids on antibody-forming cells in the eye and draining lymph nodes.
To study the effect of pretreatment of rabbits with locally administered steroids, unilateral subconjunctival injections of 10 mg. triamcinolone suspension were given 10 and 3 days before intracorneal injection of the same eye with bovine gamma globulin. We killed the rabbits 6, 9, 12, 15, and 21 days after the BGG injection, and determined the number of antibody-producing cells in the homolateral lymph nodes, corneas, and uveal tracts. Corticosteroids did not significantly affect the PFC response in the draining lymph nodes, but the number of plaque-forming cells in the corneas and uveal tracts was reduced. Steroid-treated eyes were less inflammed than control eyes. The possible mechanisms for the effect of steroids on the ocular immune response are discussed.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects*; D005123:Eye / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007634:Keratitis / Q000209:etiology / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology*; D011817:Rabbits; D014221:Triamcinolone / Q000494:pharmacology*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage; D014605:Uveitis / Q000209:etiology / Q000276:immunology; D005719:gamma-Globulins
D000305:Adrenal Cortex Hormones; D005719:gamma-Globulins; D014221:Triamcinolone; D014222:Triamcinolone Acetonide