[Study of minimal cardiac transit times in normal persons during beta-sympathicolysis (author's transl)].
The effects of single equipotent doses of Propranolol and Carazolol on cardiac haemodynamics of normal persons were investigated in a placebo-controlled double-blind study by radiocardiographic measurements of minimal cardiac transit times (MTTs). 90 min after oral application of 40 mg Propranolol a significant (p less than 0.005) prolongation of MTTs between the right auricle and the aortic root by 25% could be observed. A corresponding effect after treatment with 5 mg Carazolol was not recognizable (p greater than 0.05). Both substances strongly reduced the heart rate. The negative chronotropic effects of both beta-blockers were indistinguishable (p greater than 0.05).
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D002227:Carbazoles / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004311:Double-Blind Method; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; C014382:carazolol; D011433:Propranolol
Untersuchung über die minimalen kardialen Transitzeiten (MTTs) Herzgesunder bei beta-Sympatholyse durch Propranolol und Carazolol.