Interaction of CDP-choline with synaptosomal transport of biogenic amines and their precursors in vitro and in vivo in the rat corpus striatum.
Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.) inhibits only the in vitro uptake of DA but enhances the uptake of precursors.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D002474:Cell-Free System; D002794:Choline / Q000031:analogs & derivatives*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D007700:Kinetics; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D012701:Serotonin; D014443:Tyrosine; D003566:Cytidine Diphosphate Choline; D014364:Tryptophan; D002794:Choline; D004298:Dopamine; D009638:Norepinephrine