Penicillin immunogenicity in the presence of different pharmaceutical adjuvants.
Preliminary results in the variations of the penicillin immunogenicity in the presence of aminosugars, polysaccharides and terpenic substances are presented and the decreasings of the potential antigenicity of the penicillin molecule appeared in the presence of hexosamine molecules are estimated. It might be possible as a consequence of modifications in the early immunogenic interactions between antibiotic and serum proteins of the hipersensitive animals.
D000277:Adjuvants, Pharmaceutic; D000818:Animals; D000906:Antibodies / Q000032:analysis; D003911:Dextrans / Q000276:immunology; D004342:Drug Hypersensitivity; D000939:Epitopes; D006139:Guaiacol / Q000276:immunology; D006384:Hemagglutination; D006595:Hexosamines / Q000276:immunology; D010397:Penicillanic Acid / Q000096:biosynthesis; D010406:Penicillins / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011485:Protein Binding; D011817:Rabbits; D013729:Terpenes / Q000276:immunology
D000277:Adjuvants, Pharmaceutic; D000906:Antibodies; D003911:Dextrans; D000939:Epitopes; D006595:Hexosamines; D010406:Penicillins; D011135:Polysaccharides, Bacterial; D013729:Terpenes; D006139:Guaiacol; D010397:Penicillanic Acid