Antagonism between dopaminergic and neuroleptic drugs. I. Acute administration.
In this paper we report our results concerning the antagonism between dopaminergic (bromocriptine, apomorphine, piribedil) and neuroleptic (haloperidol, chlorpromazine, reserpine, clotiapine) drugs on the eeg and behaviour of rabbits. The Monnier and Gangloff stereotaxic method was used in order to record cortical and deep structures. The use of neurophysiologic methods also enabled us to verify the magnitude and modes of the antagonism between the two types of drugs. Particularly, the dissociation between eeg and behavioural effects of this antagonism is discussed; this fact seems to confirm the hypothesis that dopaminergic drugs have a double point of attack in the CNS.
D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001143:Arousal / Q000187:drug effects; D001971:Bromocriptine / Q000037:antagonists & inhibitors; D002490:Central Nervous System / Q000187:drug effects; D002746:Chlorpromazine / Q000037:antagonists & inhibitors; D003987:Dibenzothiazepines / Q000037:antagonists & inhibitors; D004569:Electroencephalography; D006220:Haloperidol / Q000037:antagonists & inhibitors; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010891:Piribedil / Q000037:antagonists & inhibitors; D011817:Rabbits; D012110:Reserpine / Q000037:antagonists & inhibitors
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D018377:Neurotransmitter Agents; D001971:Bromocriptine; D012110:Reserpine; D010891:Piribedil; D006220:Haloperidol; D001058:Apomorphine; D002746:Chlorpromazine