[Effect of gamma globulin on reactivity of the organism. V. Types of biological activity of gamma globulin preparations].
Biological activity of 110 series of commercial gamma-globulin preparations was studied; they were found to contain placental antigens, group-specific blood substances, gonadotropic hormones and antibodies to them. Placental antigens were found in 12% of placental and abortive gamma-globulin batches in titres of 1 : 2--1 : 16; no placental protein was revealed in donor gamma-globulin. There were group-specific blood substances in all the batches of placental and abortive gamma-globulin studied (in titres of 1 : 138--A, 1 : 112 B in the placental gamma-globulin and in titres of 1 : 48.9--A, 1 : 32--B in the abortive gamma-globulin). In the preparations from the venous blood group-specific substances were either absent or present in lowe titres only (1 : 2). The value of gonadotropic hormones in the placental gamma-globulin batches constituted 873+/-157, and in the abortive--991.4+/-147 IU/l; no gonadotropins were revealed in donor gamma-globulin. The mean titres of antibodies to gonadotropin hormone in the gamma-globulin preparations made of placental blood constituted 1 : 236+/-32, of abortive--1 : 131+/-16.6, and of the venous blood--1 : 46+/-24.7. The presence of biologically-active substances in the gamma-globulin preparations pointed to the necessity of increased requirement of their quality; additional requirements to its standardization proved to be also necessary.
D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000032:analysis; D001789:Blood Group Antigens; D006062:Gonadotropins / Q000032:analysis / Q000276:immunology; D010920:Placenta / Q000276:immunology; D005719:gamma-Globulins / Q000032:analysis* / Q000592:standards
D000906:Antibodies; D000941:Antigens; D001789:Blood Group Antigens; D006062:Gonadotropins; D005719:gamma-Globulins
Vliianie gamma-globulina na reaktivnost' organizma. Soobshchenie V. Izuchenie nekotorykh vidov biologicheskoĭ aktivnosti preparatov gamma-globulina