Laboratory investigations on "postvaccinall rabies" caused by live sheep-brain vaccine.
The viral ethiology of postvaccinal complications among 30 dogs vaccinated by live antirabies vaccine (Umeno-Doi type, sheep brain vaccine) was fully confirmed. Three lots of virulent vaccine were inoculated subcutaneously into groups of "Wistar" rats according to the different schemes. Between the 1st and 12th day after the end of the vaccination there were no isolations of fixed virus in direct and blind i.c. passages of suspensions made from the thalamus area on succkling mice and rats. Also the viral antigen in the CNS of vaccinated but apparently healthy rats was undetectable. The "postvaccinal rabies" with the next isolation of fixed r.v. in the CNS was developed experimentally in rats only following the subcutaneous injection of the crude sheep-brain's and spinal cord's suspensions--composing the materials to production of antirabies vaccine.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000382:microbiology; D004285:Dogs; D007279:Injections, Subcutaneous; D051379:Mice; D011818:Rabies / Q000209:etiology*; D011819:Rabies Vaccines / Q000009:adverse effects*; D011820:Rabies virus / Q000276:immunology / Q000302:isolation & purification; D051381:Rats; D012756:Sheep; D013116:Spinal Cord / Q000276:immunology / Q000382:microbiology; D014611:Vaccination
D000956:Antigens, Viral; D011819:Rabies Vaccines