Topical therapy of ulcerative herpetic keratitis with human interferon.
55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.
D000287:Administration, Topical; D002986:Clinical Trials as Topic; D003320:Corneal Ulcer / Q000628:therapy*; D004341:Drug Evaluation; D006801:Humans; D007372:Interferons / Q000008:administration & dosage* / Q000627:therapeutic use; D007635:Keratitis, Dendritic / Q000628:therapy*
D007372:Interferons