A new look at type I immediate hypersensitivity immune reactions.
The pathogenesis of type I disorders, particularly allergic asthma and urticaria, requires a critical review in the light of recent findings which indicate a second pathway for the release of granulocyte mediators. The isolation of enzyme activity of some of these released mediator establishes a direct link between the immunological system and bradykinin, as well as a system of self modulation of kinin activity. These findings open the door for a broader understanding of the asthmatic process and lay the foundation for integrating extrinsic and intrinsic asthma.
D001249:Asthma / Q000276:immunology*; D001491:Basophils / Q000276:immunology; D001920:Bradykinin / Q000276:immunology; D003182:Complement C5 / Q000502:physiology; D004804:Eosinophils / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007111:Immunity, Cellular; D008407:Mast Cells / Q000276:immunology
D003182:Complement C5; D001920:Bradykinin