An investigation into the roles of synaptic vesicular Mg++-ATPase in neurotransmitter release, using benzhydryl piperazines.
A series of benzhydryl piperazines was found to inhibit synaptic vesicular Mg++-ATPase. These compounds were also found to increase basal and evoked release of noradrenaline from synaptosomes. A comparison was made between the concentrations effective in inhibiting the enzyme and promoting noradrenaline release. In general, as the degree of Mg++-ATPase inhibition increased, noradrenaline release was increased. The relevance of these findings to a possible role of Mg++-ATPase in noradrenaline release is discussed.
D000109:Acetylcholine / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013572:Synaptic Vesicles / Q000201:enzymology*
D001559:Benzhydryl Compounds; D018377:Neurotransmitter Agents; D010879:Piperazines; D000251:Adenosine Triphosphatases; D008274:Magnesium; D000109:Acetylcholine; D009638:Norepinephrine