[First clinical results of radiotherapy following partial synchronization by bleomycin].
On the Ehrlich-ascites tumor and on the solide Ehrlich carcinoma of the mouse, bleomycin causes a large fixation in the (G2+M)-phase of the cell cycle of the tumor cells.  Even in certain human solide tumors, after the application of bleomycin in a predetermined period an increase of the G2 portion of the proliferating cells can be observed.  By individual control which can be peraformed rapidly and with high accuracy by impulse cytophotometry, this partial synchronisation effect can be used for radiotherapy.
D000818:Animals; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D002455:Cell Division / Q000187:drug effects; D005153:Facial Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010783:Photometry; D011867:Radioisotope Teletherapy; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D013997:Time Factors
D001761:Bleomycin
Erste klinische Ergebnisse der Strahlenbehandlung nach Teilsynchronisation mit Bleomycin