Successful renal allografts across a positive cross-match for donor B-lymphocyte alloantigens.
Seven patients received a renal allograft with negative standard and T-lymphocyte microlymphocytotoxicity cross-matches, but a positive B-lymphocyte cross-match using donor lymphocytes. In spite of this presensitisation, none underwent hyperacute rejection and all are functioning from one and a half to six months after transplantation. This procedure may help in the detection of false-positive cross-matches and possibly in detection of enhancing antibodies against a specific donor.
D001402:B-Lymphocytes / Q000276:immunology*; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies; D016030:Kidney Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007518:Isoantibodies