Renal protein metabolism in obstructive uropathy.
Measurements of serum beta 2 microglobulin and creatinine concentrations were determined in 18 patients with lower urinary tract obstruction. Nine patients were azotemic on admission to the hospital. In 3 of these patients who had normal pre-treatment serum levels of beta 2 microglobulin, the correction of obstruction was followed by return of normal renal function. The remaining 6 patients with elevated serum beta 2 microglobulin concentrations on hospitalization, showed no significant improvement in renal function parameters in the post-obstructive period. These data suggest that determination of serum beta 2 microglobulin concentrations is helpful in predicting the return of renal function in azotemic patients with obstructive uropathy.
D000368:Aged; D001609:Beta-Globulins / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications*; D011471:Prostatic Neoplasms / Q000150:complications*; D011506:Proteins / Q000378:metabolism*; D011507:Proteinuria / Q000209:etiology; D014511:Uremia / Q000209:etiology; D014555:Urination Disorders / Q000378:metabolism*
D001609:Beta-Globulins; D011506:Proteins; D003404:Creatinine