title: Induction of allergic encephalomyelitis using hydrosoluble adjuvant and the tryptophan region of myelin basic protein.
abstract: Experimental allergic encephalomyelitis has been induced in guinea pigs using the encephalitogenic tryptophan peptide as antigen and a hydrosoluble adjuvant extracted from Mycobacterium tuberculosis, var. hominis, strain H37Ra. The maximum response was observed using 100mug of adjuvant per animal. This is a quantity of adjuvant substantially higher than was necessary to induce disease utilizing the whole myelin basic protein as antigen.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced*; D005260:Female; D006168:Guinea Pigs; D007271:Injections, Intradermal; D009169:Mycobacterium tuberculosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000494:pharmacology*; D010452:Peptide Biosynthesis; D010455:Peptides / Q000008:administration & dosage; D013116:Spinal Cord / Q000473:pathology; D014364:Tryptophan / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D004676:Myelin Basic Protein; D010455:Peptides; D014364:Tryptophan