title: Occurence and cytodifferentiation of mucopolysaccharide secreting cells in the pancreas of children with nesidioblastosis.
abstract: Large numbers of mucopolysaccharide secreting cells were found in the pancreatic tissue of children with nesidioblastosis. Ultrastructural studies showed that mucus cells contained secretion granules and a characteristic smooth endoplasmic reticulum composed of an array of anastomosed tubules. The periodic acid - thiocarbohydrazide - silver reaction demonstrated the presence of glycogen in the hyaloplasm and of polysaccharides in secretion granules, the Golgi apparatus and in vesicles. A hypothesis is proposed, according to which mucus cells differentiate from a pancreatic stem cell common to both endocrine and exocrine tissues, through a mitochondria-rich intermediate cell stage.
mesh_terms: D007516:Adenoma, Islet Cell / Q000378:metabolism*; D002454:Cell Differentiation; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006025:Glycosaminoglycans / Q000378:metabolism*; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000378:metabolism*
chemical_list: D006025:Glycosaminoglycans