Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.
D000818:Animals; D001665:Binding Sites; D005721:Glutamate-Cysteine Ligase / Q000037:antagonists & inhibitors*; D005973:Glutamine / Q000378:metabolism; D005978:Glutathione / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship
D005973:Glutamine; D008717:Methionine Sulfoximine; C018649:prothionine sulfoximine; D010453:Peptide Synthases; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione