[Effect of injection of a phosphorylcholine-containing compound from Nippostrongylus brasiliensis on the infestation of the rat by this parasite].
Rats were injected intradermally with the purified phosphorycholine bearing component of the nematode Nippostrongylus brasiliensis. Eight days later they were experimentally infected with 1 X 10(3) infective larvae of the parasite. Compared to the non injected controls we showed a significant decrease in the number of adult worms able to be established in the small intestine. This protective effect seems to be due at least partly to a phenomenom being located between the skin and the lungs of the rats.
D000723:Ancylostomatoidea / Q000276:immunology*; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D000939:Epitopes; D005260:Female; D006725:Hookworm Infections / Q000276:immunology* / Q000517:prevention & control; D007114:Immunization; D007421:Intestine, Small / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D009559:Nippostrongylus / Q000276:immunology*; D010767:Phosphorylcholine / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats
D000939:Epitopes; D010767:Phosphorylcholine; D002794:Choline
Effet de l'injection d'un composé de Nippostrongylus brasiliensis portant de la phosphorylcholine sur l'infestation du rat par ce parasite