Simple preparation of a bonded cation-exchange packing material and its application to the separation of phenothiazines by high-performance liquid chromatography.
A method for introducing sulphonic acid groups on to a microparticulate silica is described. This involves formation of a mercaptopropyl bonded phase followed by oxidation to the corresponding sulphonic acid. The packing material so prepared displays cation-exchange properties and has been used to separate phenothiazines.
D014150:Antipsychotic Agents / Q000302:isolation & purification*; D002411:Cation Exchange Resins; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D010640:Phenothiazines; D013329:Structure-Activity Relationship
D014150:Antipsychotic Agents; D002411:Cation Exchange Resins; D010640:Phenothiazines