title: [Late replication and X-autosome traslocation a case with banding patterns autoradiographic and B.U.D.R. studies (author's transl)].
abstract: A patient with ovarian failure was found to have a segment of the long arm of an X chromosome translocated to the distal end of the short arm of a 2nd chromosome: 46,Xt(X;2) (q21;p25). The Barr bodies were of normal size. Autoradiographic and B.U.D.R. studies showed that the normal X was the late-replicating X. The translocated segment was late replicating in 5% without spreading effect. It is suggested that preferential inactivation of the normal X chromosome is observed when a segment of X chromosome is translocated onto an autosome. When a segment of autosome is translocated onto an X chromosome the abnormal X chromosome is consistently late-replicating. These findings may be available for other mammalian species in the balanced translocations.
mesh_terms: D000166:Acridines; D000293:Adolescent; D001345:Autoradiography; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D004261:DNA Replication; D003878:Dermatoglyphics; D005260:Female; D006801:Humans; D011796:Quinacrine; D012728:Sex Chromatin; D012730:Sex Chromosomes; D013194:Staining and Labeling; D014178:Translocation, Genetic; D014357:Trypsin
chemical_list: D000166:Acridines; D014357:Trypsin; D001973:Bromodeoxyuridine; D011796:Quinacrine
vernacular_title: Translocation X sur autosome et replication tardive. A propos d'une observation avec études des X en autoradiographie et après traitement au BUDR