[Effect of beta-adrenergic drugs on humoral immune response factors].
The authors examined the influence of beta-adrenergic stimulators Isoprenaline and Salbutamol as well as beta-adrenergic blockers Propranolol, Practolol and Pindolol on the proliferation of cells, forming plaques, 7S-immunoglobulins, hemagglutination titres and hemolytic activity of the complement. Primary stimulation with subsequent inhibition was induced by beta-adrenergic agonists and inhibition--by beta blocker Propronanol in a base of 10 mg/kg on the proliferation of cells, forming antibodies. The results were in correlation with hemagglutination titres. Salbutamol and beta-blockers inhibited immune hemolysis. The mechanisms of the observed effect are discussed in respect to the specific and nonspecific effect of the drugs used.
D000318:Adrenergic beta-Agonists / Q000276:immunology*; D000319:Adrenergic beta-Antagonists / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D003168:Complement Fixation Tests; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D007114:Immunization; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D007074:Immunoglobulin G
Vliianie na beta-adrenergichni lekarstveni serdstva vurkhu niakoi faktori na khumoralmiia imunen otgovor.