title: The interference of plasmic degradation products of human crosslinked fibrin with clot formation.
abstract: The role of plasmic degradation products of human crosslinked fibrin on polymerization of fibrin monomer and clot formation was studied. Both reactions were inhibited by Fragment DD, which formed a complex with fibrin monomer in a molar ratio 1 : 1. The rate of polymerization was slightly increased by Fragment E but it was not affected by (DD)E complex and Fragment A. Approximately the same amount of fibrin was formed in the presence and absence of Fragments A, E and the complex. It was concluded that of the degradation products of crosslinked fibrin, only Fragment DD is a potent anticoagulant at physiologic pH. The (DD)E complex is inert and Fragments A and E have only marginal effects.
mesh_terms: D001777:Blood Coagulation; D005337:Fibrin; D005341:Fibrinolysin; D006801:Humans; D006863:Hydrogen-Ion Concentration; D046911:Macromolecular Substances
chemical_list: D046911:Macromolecular Substances; D005337:Fibrin; D005341:Fibrinolysin