[Identification of several chromosome aberrations in man by the fluorescent method using quinacrine yprite].
The applications of the fluorescent staining of chromosomes with quinacrine mustard allowed to identify a dicentric Y-chromosome in two patients with defected external gynaetalies: a boy of 15 years old and a girl of 2 years old. Both the patients had mosaicism of sex chromosomes: 45, x/46, x dic (Y). The dicentric Y-chromosome, resembling chromosome, 16, had bright luminescence of the thelomeric regions characteristic of the normal Y-chromosome. Besides, a balanced autosomic translocation t (1, 14) (q 31, q 3) was found in the girl identified also with quinacrine mustard fluorescent staining.
D000293:Adolescent; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D003581:Cytodiagnosis; D012734:Disorders of Sex Development / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008297:Male; D011796:Quinacrine / Q000031:analogs & derivatives; D011797:Quinacrine Mustard; D013194:Staining and Labeling; D014424:Turner Syndrome / Q000175:diagnosis
D011797:Quinacrine Mustard; D011796:Quinacrine
Identifikatsiia nekotorykh khromosomnykh perestroek u cheloveka fluorestensentnym metodom s ispol'zovaniem akrikhi-iprita