title: Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation.
abstract: 1 Temazepam was evaluated in a strictly defined insomniac patient population under sleep laboratory conditions. Two protocols were used: a short-term (26-night) and a long-term (54-night) protocol evaluated the efficacy of the drug administered at night at 15 mg (short-term study) and 30 mg (long-term study), respectively. 2 Temazepam seemed to be both safe and effective at doses of 15 and 30 mg with up to 5 weeks of ingestion. 3 Suppression of slow wave sleep was observed at the high dose, but no suppression of REM sleep, found in studies with other benzodiazepines, was noted. 4 No evidence was found for development of tolerance or rebound effects.
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004361:Drug Tolerance; D004569:Electroencephalography; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D012895:Sleep, REM / Q000187:drug effects; D019966:Substance-Related Disorders / Q000209:etiology; D013693:Temazepam / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D013693:Temazepam