Bicarbonate-buffered peritoneal dialysis. An effective adjunct in the treatment of lactic acidosis.
Severe lactic acidosis is associated with poor prognosis. Usually, the patient is treated with massive amounts of intravenous sodium bicarbonate, which in itself carries many undesirable consequences such as fluid overload and hypernatremia. We have successfully used peritoneal dialysis with a bicarbonate-buffered dialysate in the management of severe acidosis. Bicarbonate-buffered peritoneal dialysis provided an unlimited supply of physiologic buffer over a prolonged period without causing hypervolemia or hypernatremia. Furthermore, significant amounts of lactate were removed by dialysis. We, therefore, recommend the use of bicarbonate-buffered peritoneal dialysis as an adjunct in the treatment of severe lactic acidosis.
D000138:Acidosis / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D000328:Adult; D001639:Bicarbonates / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D002021:Buffers; D002118:Calcium / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000379:methods*
D001639:Bicarbonates; D002021:Buffers; D007773:Lactates; D002245:Carbon Dioxide; D002118:Calcium