title: Changes in thoracic and right duct lymph flow  and enzyme content during skeletal muscle stimulation.
abstract: In the pentobarbital-anaesthetized dog the effect of electrical stimulation of hindlimb skeletal muscles on thoracic and right duct lymph flow and  enzyme content was examined. Increase in plasma creatine kinase (CK), L-aspartate-aminotransferase (AST) and lactic dehydrogenase (LDH) during 30-min muscle stimulation were not significantly altered by draining lymph. Both right duct and thoracic duct lymph flow trebled during stimulation. At the same time, the activity of the three enzymes examined decreased in right duct lymph and increased in thoracic duct lymph. Of the latter,  only the increase in lymph CK was of a sufficient magnitude to have resulted in a detectable increase in plasma CK. CK was the smallest of the three enzymes studied and apparently preferentially entered the lymph, suggesting that the larger AST and  LDH molecules were not likely to have entered the blood plasma directly from skeletal muscle. Rather their entry from some other  tissue, possibly the formed elements of the blood, is indicated.
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D001831:Body Temperature; D003402:Creatine Kinase / Q000378:metabolism*; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate; D006614:Hindlimb; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008196:Lymph / Q000201:enzymology / Q000502:physiology*; D008208:Lymphatic System; D008297:Male; D009132:Muscles / Q000502:physiology*; D013897:Thoracic Duct
chemical_list: D001798:Blood Proteins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase