Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.
The influence of some biogenic amines and amine-receptor-blocking drugs in the growth rate of human colorectal carcinomas propagated as s.c. xenografts in immune-deprived mice was studied. In mice treated with adrenaline, a beta-adrenergic agonist, the growth of xenografts was suppressed for 2 days, after which growth was resumed at a rate similar to that in control animals. Treatment with the phosphodiesterase inhibitor theophylline prolonged the adrenaline-induced inhibition of growth. Treatment with the beta-adrenergic antagonist sotalol or practolol increased the rate of tumour growth. Treatment with either serotonin or the histamine H2-receptor agonist Dimiprit had no effect on tumour growth rate. However, the antiserotoninergic drug BW 501C and the histamine H2-receptor antagonist cimetidine each caused short-term suppression of tumour growth.
D000322:Adrenergic Agonists / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012004:Rectal Neoplasms / Q000188:drug therapy*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology; D014183:Transplantation, Heterologous
D000322:Adrenergic Agonists; D001679:Biogenic Amines; D012702:Serotonin Antagonists; D013565:Sympatholytics; D012701:Serotonin; D002927:Cimetidine