title: [Accident during local anesthesia in a patient with antiarrhythmic therapy].
abstract: A side reaction of antiarrhythmic treatment in a 18-year-old patient with congestive cardiomyopathy is reported. During treatment with high doses of aprindine cerebral convulsions occurred. After ceasing the medication temporarily, a pacemaker revision was done in local anesthesia. Cerebral convulsions reappeared after injection of the local anesthetic. The patient died due to cardiac arrest. It is discussed that some amount of the local anesthetic agent (mepivacaine) was absorbed from the tissue elevating the blood level of local anesthetic drugs (aprindine and mepivacine) into the toxic range, thus producing cerebral convulsions, augmenting the stimulation threshold and depressing the automaticity of the heart. It is urged that antiarrhythmic treatment should be stopped before local anesthesia will be performed.
mesh_terms: D000293:Adolescent; D000772:Anesthesia, Local / Q000009:adverse effects; D001073:Aprindine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D005117:Cardiac Complexes, Premature / Q000150:complications / Q000188:drug therapy; D009202:Cardiomyopathies / Q000150:complications*; D004347:Drug Interactions; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D007192:Indenes / Q000009:adverse effects*; D008297:Male; D008619:Mepivacaine / Q000009:adverse effects*; D010138:Pacemaker, Artificial; D012640:Seizures / Q000139:chemically induced
chemical_list: D007192:Indenes; D001073:Aprindine; D008619:Mepivacaine
vernacular_title: Zwischenfall während der Lokalanästhesie bei einem Patienten unter antiarrhythmischer Therapie