title: The influence of binder concentration on the bond formation of pharmaceutical granules.
abstract: The formation of particle mucilage bonds with dicalcium phosphate dihydrate and starch mucilage binder reduces the B.E.T. nitrogen adsorption surface are from 196 to 0.96 m2 g-1. The maximum reduction (40%) of granule surface area at a binder concentration of 10% w/w corresponded to similar optima in friability, compressability and median granule size. Surface and pore-void structural analysis by mercury intrusion could not discriminate between pore-void sizes in the range 0.5-100 nm. Nitrogen adsorption measurements showed, however, that the microporous surface area decreased from 0.3 to 0.18 m2 g-1 as binder surface coverage increased over the concentration range 2 to 20% w/w starch mucilage.
mesh_terms: D002130:Calcium Phosphates; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods; D005079:Excipients; D014677:Pharmaceutical Vehicles; D013213:Starch; D013607:Tablets
chemical_list: D002130:Calcium Phosphates; D005079:Excipients; D014677:Pharmaceutical Vehicles; D013607:Tablets; D013213:Starch