Etonitazene as a reinforcer: oral intake of etonitazene by rhesus monkeys.
Drinking of etonitazene HCI was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (microgram/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D005502:Food; D005508:Food Deprivation; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D012054:Reinforcement, Psychology
D001562:Benzimidazoles