title: [The effect of disopyramide phosphate in extrasystole at rest and on exercise (author's transl)].
abstract: The antiarrhythmic action of disopyramide phosphate was compared to placebo in a randomized double blind trial at rest and under physical exertion in two groups each of 10 patients with extrasystoles. The exercise was carried out on the bicycle ergometer in a recumbent posture in stages of 25 watts at 2 minutes each without a break to the limit of the individual. The extrasystoles were counted at fixed registration periods. It was shown that the number of extrasystoles in the disopyramide group was significantly lower in comparison to the placebo group (P less than 0.05).
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D005117:Cardiac Complexes, Premature / Q000188:drug therapy / Q000503:physiopathology*; D004206:Disopyramide / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011725:Pyridines / Q000494:pharmacology*; D011802:Quinidine / Q000008:administration & dosage; D012146:Rest
chemical_list: D000889:Anti-Arrhythmia Agents; D010919:Placebos; D011725:Pyridines; D004206:Disopyramide; D011802:Quinidine
vernacular_title: Wirkung von Disopyramid-phosphat bei Extrasystolie in Ruhe und unter Belastung