Vaccination of an adolescent group with A (H3N2) + A(HSW1N1) bivaccine before an A (H1N1) influenza epidemic.
A group of 35 adolescents aged 18--22 years were vaccinated intradermally with 0.2 ml of a mixed A (H3N2) + A (Hsw1N1) formolized vaccine and revaccinated with A (Hsw1N1) monovaccine 10 days before an A (H1N1) influenza epidemic. The vaccination had no effect on morbidity or the clinical course of disease. Serology revealed a primary immune response to A (Hsw1N1) and a booster response to A (H3N2). Apparently, prevention of a new influenza subtype by formolized vaccine possessing only the corresponding neuraminidase type is ineffective.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis*; D006389:Hemagglutinins, Viral / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000494:pharmacology; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control; D009439:Neuraminidase / Q000276:immunology; D014611:Vaccination
D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D009439:Neuraminidase