Karyology of a human colonic carcinoma (GW-39) serially xenografted in hamsters and in nude mice.
A karyological analysis of the G-banded chromosomes of the serially transplantable GW-39 human colonic carcinoma was undertaken. GW-39 cells harvested from hamsters, nude (athymic) mice and cell cultures from 1972 to 1976 revealed a hypodiploid stemline of 45 human chromosomes, with a consistent loss of a 21-chromosome. No apparent alterations of the near-diploid stemline resulted during long-term xenogeneic propagation of this human cancer line.
D000818:Animals; D002877:Chromosomes, Human; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D006224:Cricetinae; D006801:Humans; D007621:Karyotyping; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011003:Ploidies; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured