The effect of propranolol on normal physiologic tremor.
It has been demonstrated that intravenous propranolol produces a 34-60% decrease in normal physiological tremor. The decrease, in response to small doses of the drug (less than 12 mug/kg), was linearly proportional to the baseline tremor size and occurred only following a 10 min delay. It is possible that the effect on tremor is due to the formation of a highly specific centrally acting metabolite of propranolol.
D000328:Adult; D002490:Central Nervous System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D011433:Propranolol / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D011433:Propranolol