Preventive effect of hapten-reactive thymus-derived helper lymphocytes on the tolerance induction in hapten-specific precursors of antibody-forming cells.
The role(s) of helper T lymphocytes in preventing or altering tolerance induction in DNP-specific B lymphocytes was studied. As DNP-reactive helper T cells were reactive against the DNP-portion of the DNP-D-GL molecule, we could probe definitively the physiological role of helper T cells in preventing tolerance induction in B lymphocytes by DNP-D-GL. The results demonstrated that the induction of DNP-specific B cell tolerance by DNP-D-GL can be completely prevented by the presence of DNP-reactive helper T cells, and provide evidence that one critical role of helper T cell participation in humoral responses to antigens is to circumvent the development of a tolerogenic signal that, in the absence of such T cell function, might otherwise ensue after binding of the antigenic determinants by specific B lymphocytes.
D000681:Amylases; D000818:Animals; D000918:Antibody Specificity; D000921:Antibody-Producing Cells; D001202:Ascitic Fluid / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D001412:Bacillus subtilis / Q000201:enzymology; D002352:Carrier Proteins; D004140:Dinitrophenols / Q000276:immunology; D005971:Glutamates; D006241:Haptens; D006433:Hemocyanins; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D007116:Immunization, Passive; D008239:Lysine; D051379:Mice; D011828:Radiation Chimera; D012710:Serum Albumin, Bovine; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D005719:gamma-Globulins
D002352:Carrier Proteins; D004140:Dinitrophenols; D005971:Glutamates; D006241:Haptens; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine; D006433:Hemocyanins; D000681:Amylases; D008239:Lysine