title: Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide.
abstract: The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.
mesh_terms: D000818:Animals; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism*; D000882:Haplorhini; D008099:Liver / Q000201:enzymology*; D008255:Macaca radiata; D009243:NAD / Q000494:pharmacology*; D009249:NADP / Q000494:pharmacology*; D013763:Tetrahydrofolates / Q000378:metabolism; D014166:Transferases / Q000378:metabolism*
chemical_list: D013763:Tetrahydrofolates; D009243:NAD; D009249:NADP; D014166:Transferases; D012696:Glycine Hydroxymethyltransferase