Serum proteins in diseases of the liver.
In 9 groups of liver diseases, 11 serum protein parameters were studied. Prealbumin, retinol-binding protein, albumin, alpha-lipoprotein and Normotest (NT) were usually highly intercorrelated and separated best among groups with different types of functional impairment. Haptoglobin, C3 and total iron-binding capacity were probably also sometimes reduced by restricted protein synthesis but appeared to be more easily affected by other factors, alpha1-antitrypsin was often increased in different liver diseases, but a pattern compatible with the "acute-phase reaction" was regularly present only in hepatic tumors. Bile retention was often accompanied by relatively high levels of ceruloplasmin, C3, and alpha-lipoprotein and by high NT values.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006505:Hepatitis / Q000097:blood; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood; D008107:Liver Diseases / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D001798:Blood Proteins; D003176:Complement C3; D006242:Haptoglobins; D008075:Lipoproteins, HDL; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D002570:Ceruloplasmin; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase