Effect of ochratoxin and aflatoxin on serum proteins, complement activity, and antibody production to Brucella abortus in guinea pigs.
The effect of ochratoxin alone and in combination with aflatoxin and Brucella abortus antigen on complement activity, serum proteins, and antibody response in guinea pigs was investigated. Ochratoxin did not affect complement activity or antibody response and there was no interaction between ochratoxin and aflatoxin on any of the responses tested. Ochratoxin significantly lowered the level of beta-globulin in serum of guinea pigs. There was no significant interaction between aflatoxin and antigen on lowering of the serum albumin levels of guinea pigs.
D000348:Aflatoxins / Q000494:pharmacology*; D000510:Alpha-Globulins / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000917:Antibody Formation / Q000187:drug effects*; D000942:Antigens, Bacterial; D001609:Beta-Globulins / Q000378:metabolism; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000378:metabolism*; D002003:Brucella abortus / Q000276:immunology*; D002214:Capsules; D003165:Complement System Proteins / Q000096:biosynthesis*; D005260:Female; D006168:Guinea Pigs; D007279:Injections, Subcutaneous; D009793:Ochratoxins / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism
D000348:Aflatoxins; D000510:Alpha-Globulins; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001609:Beta-Globulins; D001798:Blood Proteins; D002214:Capsules; D009793:Ochratoxins; D012709:Serum Albumin; D005719:gamma-Globulins; D003165:Complement System Proteins