Environmental chemical-induced modification of cell-mediated immune responses.
It is therefore proposed that: 1) environmental chemicals can have specific mechanisms of toxicity and can influence antibody-mediated immunity while having no detectable effect on cell-mediated immunity, 2) immune dysfunction is related to exposure time to a chemical and the tissue concentration of that chemical, 3) recovery of immune function may occur even though chemical exposure continues, and 4) a single assay of immune function may not be appropriate to detect chemical induced immune dysfunction.
D000818:Animals; D001140:Aroclors / Q000009:adverse effects; D001835:Body Weight; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D006087:Graft vs Host Reaction; D006168:Guinea Pigs; D006581:Hexachlorobenzene / Q000009:adverse effects; D007111:Immunity, Cellular / Q000187:drug effects*; D008099:Liver / Q000033:anatomy & histology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D009929:Organ Size; D011817:Rabbits; D013154:Spleen / Q000033:anatomy & histology / Q000166:cytology; D013950:Thymus Gland / Q000033:anatomy & histology
D001140:Aroclors; D004785:Environmental Pollutants; D008934:Mitogens; D006581:Hexachlorobenzene