[Changes in postsynaptic excitation processes in the presence of phenazepam].
The new psychotropic drug phenazepam inhibits the impulse activity of the neurons which compose visceral ganglia of the garden snail (Helix aspersa) and suppresses stimulating postsynaptic potentials arising in application of acetylcholine to the membrane of isolated neurons. The electrostimulating membrane parameters are not generally changed. Postsynaptic depression of the stimulation of the cholinoreceptive membrane is suggested to be one of the possible mechanisms of the pharmacological action of the drug.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects
D014151:Anti-Anxiety Agents; D011950:Receptors, Cholinergic; D001569:Benzodiazepines; D000109:Acetylcholine
Izmeneniia postsinapticheskikh protsessov vozbuzhdeniia v prisutstvii fenazepama.