Discriminative stimulus properties of psychomotor stimulants in the cat.
Cats were trained to choose between two levels or an operant chamber using interoceptive cues provided by d-amphetamine or saline as the discriminative stimuli. Following training, stimulus generalization was observed to additional doses of d-amphetamine and cocaine. but not to morphine. Clozapine blocked the generalization of the drug discrimination response to d-amphetamine, but had no effect on generalization to cocaine. These data indicate that discriminative stimulus properties of psychomotor stimulants, previously described in rats, are similar in cats.
D000818:Animals; D002415:Cats; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology; D012055:Reinforcement Schedule
D000697:Central Nervous System Stimulants; D009020:Morphine; D003042:Cocaine; D003024:Clozapine; D003913:Dextroamphetamine