title: [Kinetics of action of Vectarion. Ventilatory chemo-stimulant (author's transl)].
abstract: Vectarion has a powerful respiratory stimulant effect in animals and in man which is manifested by a significant and lasting increase in ventilation, as shown by a marked lowering of arterial P. CO2 and an increase in blood pH. This activity is maintained in dogs with experimental alkalosis or acidosis as well as during morphine or oxygen-induced respiratory depression. This respiratory stimulating action originates at the level of the aortic and carotid chemo-receptors: this explains why Vectarion is devoid of any epileptogenic risk. The aim of the present study was to demonstrate the peak of activity and duration of action of an intravenous perfusion of Vectarion, in such a way as to be able to plan administration all through the day and night.
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010879:Piperazines / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000188:drug therapy*; D013147:Spirometry; D013268:Stimulation, Chemical; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D014227:Triazines; D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Cinétique d'action du Vectarion, chémo-stimulant ventilatoire.