Fibrinolysis in the rat lung after intravenous tumour cell injection.
Intravenous injection of a tumour cell suspension in rats induced an early tendency to increased fibrinolysis followed by a temporarily, significantly decreased fibrinolytic activity in lung vessels. These reactions were similar to those previously found after a large trauma and might reflect the vascular reaction to thrombotic material trapped in the lung microcirculation.
D000818:Animals; D005342:Fibrinolysis; D007275:Injections, Intravenous; D008168:Lung / Q000098:blood supply*; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000473:pathology*