Effects of thymus-independent (B) cells and the H-2 gene complex on antiviral function of immune thymus-derived (T) cells.
Antiviral activity in vivo exerted by ectromelia virus-immune spleen cells transferred to ectromelia-infected recipients and cytotoxicity against virus-infected target cells in vitro were both properties of non-immunoglobulin (Ig)-bearing cells (which included T cells). Ig-bearing cells, including thymus-independent (B) cells and antibody-secreting cells, were much less active in vivo when injected alone and tended to block rather than amplify the effect triggered by T cells. Ig-bearing cells were also slightly active in vitro, possibly because some T cells have detectable Ig. Antiviral effects in cell transfer experiments were seen only when immune cell donors and infected recipients shared the same H-2 gene complex. These results are consistent with the hypothesis that the T cell response to ectromelia infection is directed against specific virus-induced change(s) in antigen(s), specified by gene(s) in the H-2 complex, which appear in virus-infected cells.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D003601:Cytotoxicity Tests, Immunologic; D004482:Ectromelia, Infectious / Q000276:immunology*; D000939:Epitopes; D005796:Genes; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007136:Immunoglobulins; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011213:Poxviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D000939:Epitopes; D006649:Histocompatibility Antigens; D007136:Immunoglobulins