title: Macrophage killing capacity. Aspects of mechanism.
abstract: Immune macrophages have the capacity to kill in mixed macrophage cultures (MMC) allogeneic macrophages bearing the alloantigens used for immunization. The killing is expressed by a lytic mechanism as neither phagocytosis nor fusion between effector and target cells could be detected by E.M. T but not B lymphocytes isolated from immune spleen cells, are able to "arm" syngeneic nonimmune macrophages and render them cytotoxic. It is suggested that mediator(s) and/or membranal components are released from T cells and attach to macrophages. Such an "arming" factor enables the macrophage to recognize and kill target cells.
mesh_terms: D000818:Animals; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D007519:Isoantigens; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology; D014357:Trypsin / Q000494:pharmacology; D005719:gamma-Globulins / Q000494:pharmacology
chemical_list: D000906:Antibodies; D007519:Isoantigens; D005719:gamma-Globulins; D014357:Trypsin