The influence of cholinergic transmitter substances on the incorporation of (14C)-leucine and (3H)-fucose into the total proteins of hippocampus in vivo and in vitro.
The incorporation of (14C)-leucine into the total proteins of the hippocampus is inhibited by high concentrations of cholinergic agonists, with nicotinic substances (such as 1,1-dimethyl-4-phenyl-piperazine) being more effective than muscarinic compounds (such as arecoline and pilocarpine). Under these conditions the incorporation of (3H)-fucose is not influenced.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D005643:Fucose / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats
D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D010862:Pilocarpine; D005643:Fucose; D001115:Arecoline; D004246:Dimethylphenylpiperazinium Iodide; D007930:Leucine