title: Seizure proneness and neurotransmitter uptake.
abstract: The ability of midbrain homogenates from two strains of mice to accumulate several putative neurotransmitters, or their precursor in the case of acetylcholine, has been examined. The high-affinity transport mechanisms toward glutamate, GABA, dopamine, and glycine were similar in both strains. The seizure-prone DBA21BG strain had a significantly higher capacity to transport choline than did the relatively seizure-resistant C57BL/6 IBC mice. Howaver, no difference in the density of muscarinic binding sites in the two mouse strains was found.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002794:Choline / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D008636:Mesencephalon / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000032:analysis; D012640:Seizures / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D018377:Neurotransmitter Agents; D011976:Receptors, Muscarinic; D005680:gamma-Aminobutyric Acid; D002794:Choline; D005998:Glycine; D004298:Dopamine