title: Familial fatal Parkinsonism with alveolar hypoventilation and mental depression.
abstract: The clinical, pathological, and neurochemical characteristics of a newly recognized inherited neurological disorder are reported. Lethargy and mental depression are early symptoms, followed by mild parkinsonism and progressive weight loss. Failure of automatic respiratory control develops and may result in sudden death. Advanced degeneration of the substantia nigra, cell loss and gliosis of the basal ganglia, and focal gliosis in the medulla are seen on pathological study. Degeneration of the nigrostriatal dopaminergic system is evidenced by low levels of tyrosine hydroxylase, dopamine, homovanillic acid, and L-dopa decarboxylase in postmortem brain samples. Taurine concentrations in fasting plasma and CSF are somewhat depressed; brain contents of taurine are within normal limits.
mesh_terms: D001921:Brain / Q000201:enzymology / Q000473:pathology; D001923:Brain Chemistry; D003863:Depression / Q000235:genetics*; D004296:Dopa Decarboxylase / Q000378:metabolism; D004298:Dopamine / Q000032:analysis; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006719:Homovanillic Acid / Q000032:analysis; D006801:Humans; D007040:Hypoventilation / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010375:Pedigree; D013577:Syndrome; D013654:Taurine / Q000032:analysis; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000032:analysis
chemical_list: D013654:Taurine; D005680:gamma-Aminobutyric Acid; D014446:Tyrosine 3-Monooxygenase; D004296:Dopa Decarboxylase; D005968:Glutamate Decarboxylase; D004298:Dopamine; D006719:Homovanillic Acid