Identification of actin-like proteins in alcoholic hyaline by immunofluorescence.
Immunofluorescence studies on human liver from alcoholic patients demonstrate that alcoholic hyaline (Mallory body) binds immune sera containing anti-actin antibodies. These findings, establishing that alcoholic hyaline is endowed with contractile proteins, strongly support the actin microfilament nature of the Mallory body.
D000199:Actins / Q000276:immunology / Q000302:isolation & purification*; D000437:Alcoholism / Q000150:complications; D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D001707:Biopsy, Needle; D005455:Fluorescent Antibody Technique; D006041:Goats / Q000276:immunology; D006801:Humans; D006818:Hyalin / Q000032:analysis*; D008099:Liver / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology*; D011506:Proteins / Q000302:isolation & purification*
D000199:Actins; D000888:Antibodies, Anti-Idiotypic; D011506:Proteins