title: Antiviral activity of benzothiazole and benzothiazolinethione derivatives in cell cultures.
abstract: The virus inhibitory activity of benzothiazole, benzothiazolinethione and naphthothiazole derivatives was tested with vaccinia virus, Newcastle disease virus (NDV) and western equine encephalomyelitis (WEE) virus in the agar-diffusion plaque-inhibition test. Among 58 compounds examined, 5 showed medium activity and selectivity with vaccinia virus. The highest selective effect was found with 3-(2-ethylthio-6-benzothiazolylaminomethyl)-2-benzothiazolinethione. A much lower inhibitory effect was observed with several derivatives against WEE virus. One derivative (2-mercaptobenzothiazole) showed a low inhibitory effect against NDV.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004667:Encephalitis Virus, Western Equine / Q000187:drug effects* / Q000254:growth & development; D009522:Newcastle disease virus / Q000187:drug effects* / Q000254:growth & development; D013844:Thiazoles / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects
chemical_list: D013844:Thiazoles