Effects of halopemide, a new psychotropic agent, on the uptake of serotonin by blood platelets.
The influence of halopemide, a new psychotropic agent, and some putative metabolites on the uptake of 14C-5-HT into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 and R 29676 and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative metabolite of halopemide, were totally devoid of activity.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003024:Clozapine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006626:Hippurates / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000097:blood*
D014150:Antipsychotic Agents; D001562:Benzimidazoles; D006626:Hippurates; D010880:Piperidines; D012701:Serotonin; D003024:Clozapine; D007099:Imipramine