title: Pulmonary hyalinosis in dogs.
abstract: Pulmonary hyalinosis occurred in Beagles exposed to radon daughters with uranium ore dust. The lesion was composed of alveolar cells distended with material positive for periodic acid-Schiff (PAS) and oil red O that ultrastructurally consisted of a whorled arrangement of lamellar membranes suggestive of a storage disease. The high incidence in exposed dogs and the ultrastructural appearance suggested the material originated endogenously as a degenerative response to injury.
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004391:Dust; D006818:Hyalin; D008168:Lung / Q000648:ultrastructure; D008171:Lung Diseases / Q000473:pathology / Q000662:veterinary*; D011009:Pneumoconiosis / Q000473:pathology / Q000662:veterinary; D011833:Radiation Injuries, Experimental / Q000473:pathology; D011886:Radon; D014501:Uranium
chemical_list: D004391:Dust; D014501:Uranium; D011886:Radon