Ia antigens and Fc receptors.
The function of Fc receptors (FcR) on mouse spleen cells as detected by a sensitive rosetting system using antibody-labeled bovine erythrocytes as indicator cells was shown to be inhibited by anti-Ia antiserum. Furthermore, the Ia specificities of each I-region sublocus (I-1A, I-1B, I-C) seem to be associated with FrR, since FcR function was also inhibited when the blocking anti-Ia antiserum recognized only restricted Ia specificities. Antiserum directed against antigens coded for by the K-end of the major histocompatibility complex did not inhibit FcR function. The function of C3 receptors and Fc receptors on macrophages and Fc-receptor-positive cells in the fetal liver was not inhibited by anti-Ia antiserum. These findings are discussed in view of a possible arrangement of Fc receptors and Ia antigens on the cell membrane.
D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens; D001202:Ascitic Fluid / Q000276:immunology; D001666:Binding Sites, Antibody; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D007104:Immune Adherence Reaction; D007106:Immune Sera / Q000494:pharmacology; D007141:Immunoglobulin Fc Fragments; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D000936:Antigen-Antibody Complex; D000941:Antigens; D000939:Epitopes; D007106:Immune Sera; D007141:Immunoglobulin Fc Fragments