Influence of sex hormones on gamma-glutamyltranspeptidase activity in rats serum with Morris hepatoma 5123 D.
The Stilbestrol treatment of the female rats with the Morris hepatoma 5123 D resulted in decrease of the gamma-glutamyl-transpeptidase (GGTP) activity in serum and in hepatoma, but only during the treatment. Given to the male rats under the same conditions, Stilbestrol had no influence on the GGTP activity. Castration of males was the cause of the GGTP activity decay in hepatoma and in serum, but it was not the case with females. Sustanon diminished the GGTP activity in serum of the female rats with hepatoma.
D000818:Animals; D002369:Castration; D002455:Cell Division / Q000187:drug effects; D004054:Diethylstilbestrol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008297:Male; D051381:Rats; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D014018:Tissue Distribution; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004054:Diethylstilbestrol; D005723:gamma-Glutamyltransferase