Prenatal diagnosis of congenital anomalies in an intrauterine growth retarded fetus.
Chromosome analysis of amniotic fluid cells and amniotic fluid alpha-fetoprotein determinations were used to investigate a fetus with severe intrauterine growth retardation in the third trimester. The karyotype was 47,XY,18+ and increased alpha-fetoprotein levels indicated the presence of congenital malformations. We suggest that when severe fetal growth retardation is detected early in the antepartum course, amniotic fluid alpha-fetoprotein and amniotic fluid cell chromosome studies be done to determine if congenital anomalies may be an etiological factor.
D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000293:Adolescent; D000653:Amniotic Fluid / Q000032:analysis; D002902:Chromosomes, Human, 16-18; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006130:Growth Disorders / Q000175:diagnosis; D006554:Hernia, Umbilical / Q000175:diagnosis; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins