title: EEG findings in heroin addicts during induction and maintenance on methadone.
abstract: This study investigated changes in the EEG of addicts initially on heroin as they progressed through the induction and maintenance phases of a methadone program. Spectral analysis of bipolar recordings revealed significant consistent differences only in the eyes-closed resting state. Patients under the influence of heroin showed large sharp peaks at 9-10 c/sec, particularly in the parieto-occipital recording. Methadone induction led either to marked reduction of this peak and widening of alpha band activity or to an increase in frequency of the alpha peak to 12 c/sec. After several months of methadone the alpha peak was still absent unless heroin abuse was present, a theta peak was present in three of four patients, and the alpha bandwidth remained broad. Changes in the theta band were more difficult to interpret.
mesh_terms: D000293:Adolescent; D000328:Adult; D000513:Alpha Rhythm; D002540:Cerebral Cortex / Q000187:drug effects; D004569:Electroencephalography; D005059:Euphoria / Q000187:drug effects; D003932:Heroin / Q000009:adverse effects; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008691:Methadone / Q000627:therapeutic use*; D012146:Rest; D013826:Theta Rhythm
chemical_list: D003932:Heroin; D008691:Methadone