[Effect of neuroleptics on spontaneous and evoked noradrenaline release from brain nerve endings of rats].
Spectrofluorometric determination of the noradrenaline content in the non-purified fraction of the rat's brain stem synaptosomes and radioisotope method resulted in finding that carbidine is capable to release noradrenaline from the nerve endings. Azabutyron, droperidol and fluphenazine had no noticeable effect on this process. The release of noradrenaline with carbidine depends upon the presence of Ca2+ ions in the medium. This neuroleptic is also capable of intensifying the release of the mediator provoked by the potassium depolarization of the nerve endings.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D002090:Butyrophenones / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology; D004347:Drug Interactions; D005476:Fluphenazine / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism
D014150:Antipsychotic Agents; D002090:Butyrophenones; D002243:Carbolines; D010879:Piperazines; D004329:Droperidol; D011188:Potassium; D005476:Fluphenazine; D002118:Calcium; D009638:Norepinephrine
Vliianie neĭroleptikov na spontannoe i vyzvannoe vysvobozhdenie noradrenalina iz nervnykh okonchaniĭ mozga krysy.