[The use of new immunoglobulin preparation, enriched in IgA and IgM (IgGAM)].
The clinical results obtained with fraction IgGAM are reported. Different types of antibody deficiency syndromes have successfully been treated : 8 cases of Bruton-type agammaglobulinemia. In one of these case a tenacious Pseudomonas infection cleared off during the treatment. Two cases of non sex-linked familial agammaglobulinemia. Three cases of isolated IgM deficiency. Five cases of isolated IgA deficiency. Five cases with Soothill type IgA deficiency associated with high IgE levels. Five cases of septicemia of the new-born. Three cases with acquired agammaglobulinemia and in the premature infant (5 cases). No side-effects nor appearance of anti-IgA antibodies have been observed.
D000328:Adult; D000361:Agammaglobulinemia / Q000628:therapy; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D002648:Child; D002986:Clinical Trials as Topic; D004406:Dysgammaglobulinemia / Q000628:therapy; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification*; D007070:Immunoglobulin A / Q000008:administration & dosage*; D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M / Q000008:administration & dosage*; D007167:Immunotherapy; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy; D007273:Injections, Intramuscular; D008297:Male; D018805:Sepsis / Q000628:therapy; D005719:gamma-Globulins / Q000302:isolation & purification
D000888:Antibodies, Anti-Idiotypic; D007106:Immune Sera; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M; D005719:gamma-Globulins
Utilisation d'une nouvelle préparation d'immunoglobulines enrichie en LgA et en IgM (IgGAM)