title: K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axon membrane.
abstract: In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKa of about 6.9, and that is accessible to protons only from the intracellular side of the membrane.
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D049832:Decapodiformes; D004553:Electric Conductivity; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D011188:Potassium / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D011188:Potassium