[Correlation of in vitro testing and therapeutical results in animal transplanted tumors after cytostatic treatment].
The antineoplastic activity of 5 substances was tested in vivo and in vitro on four different tumours (plasmocytoma and melanoma Fortner III of the Syrian golden hamster, the Walker carcinosarkoma 256 and an adenocarcinoma of the rat). The substances involved were 2,3,5-triethyleniminobenzoquinone-(1,4) (triaziquone), actinomycin D, podophyllinic ethylhydrazide (mitopodozide), bleomycin and adriamycin hydrochloride. The effect of the substances in vivo was measured on the size of the tumour, and in vitro on the incorporation of 3-H-thymidine and 3-H-uridine in short-term incubations of tumour-cell suspensions. No correlation was observed between the 3-H-thymidine incorporation in vitro and the response of the tumours in vivo. On the other hand, the 3-H-uridine incorporation in the tumour-cell suspensions in vitro was in good agreement with the results of therapy in the animal experiments. This is compatible with the results of earlier experiments using other substances to investigate the possible correlation between tumour therapy and in vitro tests.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000378:metabolism; D006224:Cricetinae; D003609:Dactinomycin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D066298:In Vitro Techniques; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000378:metabolism; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D010954:Plasmacytoma / Q000188:drug therapy / Q000378:metabolism; D011033:Podophyllin / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014228:Triaziquone / Q000627:therapeutic use; D014529:Uridine / Q000378:metabolism
D000970:Antineoplastic Agents; D001761:Bleomycin; D003609:Dactinomycin; D004317:Doxorubicin; D011033:Podophyllin; D014228:Triaziquone; D013936:Thymidine; D014529:Uridine
Korrelation von In-vitro-Testung und Therapieergebnis bei tierischen Transplantationstumoren nach Behandlung mit Zytostatika