Metabolism of mesocarb in the rat.
1. Rats treated orally with [14C]mesocarb (I; 3-(1-methyl-2-phenyl[2-(14C]ethyl)-N-(phenylaminocarbonyl)sydnone imine) (50 mg/kg) excrete 35% of the radioactivity in 24 h urine and 51% in 48 h urine. 2. Only traces of unchanged drug were found in urine. Hydroxy-mesocarb (II), dihydroxy-mesocarb (III), amphetamine (VII) and the conjugates of II and III account for 86% of the urinary radioactivity. 3. Cannulated male rats excrete about 40% of the radioactivity in 30 h in bile, mainly as conjugates of II and III.
D000661:Amphetamine / Q000652:urine; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D000697:Central Nervous System Stimulants / Q000378:metabolism* / Q000652:urine; D008297:Male; D010069:Oxadiazoles / Q000378:metabolism*; D051381:Rats; D013558:Sydnones / Q000378:metabolism* / Q000652:urine
D000697:Central Nervous System Stimulants; D010069:Oxadiazoles; D013558:Sydnones; D000661:Amphetamine; C009257:sidnocarb