The effect of etilefrine (Effortil) on central hemodynamics and aorto-coronary bypass blood flow. A pre-operative study.
In an attempt to elucidate the function of an aorto-coronary bypass in patients with coronary artery obliterative disease, intravenous injection of etilefrine was used to bring about variations of central hemodynamics. Etilefrine proved to cause a significant increase of cardiac output (QPA), mean systemic blood pressure and aorto-coronary bypass flow. Calculations of peripheral myocardial resistance showed a rather pronounced decrease in all vascular regions studied. There was no change of central venous pressure. The decrease of the myocardial vascular resistance, as shown by the increase of aorto-coronary bypass flow, is indicative of the myocardial vascular capacity. Hence, it may be of value as a prognostic test.
D000328:Adult; D000787:Angina Pectoris / Q000601:surgery*; D001783:Blood Flow Velocity; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects*; D005039:Etilefrine; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000031:analogs & derivatives
D010656:Phenylephrine; D005039:Etilefrine