[The india ink phagocytosis by monocytes and granulocytes during acute and chronic consumption coagulopathy].
During generalized intravascular coagulation (GIC) the polimerisation products of fibrinogen are phagocytized by the reticulo-endothelial system of the liver and spleen. Thus an inhibition of the clearance of RES could be detected in a progressed stage of the shock and GIC; this can also be represented by a decrease of India ink storage. In the present work the authors investigate the behavior of monocytes and granulocytes in the peripheral blood in GIC. Approximately 80% of cells will usually phagocytize and concentrate India ink granules, if heparinized blood mixed with India ink is incubated for two hours at 37 degrees C. A decrease of the India ink phagocytosis was detected in 6 patients and in 10 dogs during the shock. This observation corresponds to the behavior of hepatolienal RES during this condition.
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000276:immunology*; D004285:Dogs; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D012157:Mononuclear Phagocyte System / Q000276:immunology; D010587:Phagocytosis; D012771:Shock, Hemorrhagic / Q000150:complications
Die Tuschephagozytose der Mono- und Granulozyten während der akuten und chronischen Verbrauchskoagulopathie