title: [Interaction of labetalol with alpha- and beta-adrenergic receptors : biochemical study (author's transl)].
abstract: The interaction of a new antihypertensive agent, labetalol was demonstrated in subcellular preparations enriched in alpha- and beta-adrenergic receptors. This result give direct confirmation of pharmacological data observed in isolated organs and in vivo. It illustrates the value of biochemical studies of receptors in order to define the mechanism of action of drugs.
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007741:Labetalol / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D007741:Labetalol
vernacular_title: Interaction du labétalol avec les récepteurs alpha- et bêta-adrénergiques : étude biochimique.