title: Biological properties of myeloma proteins.
abstract: The paraproteins frequently cause major symptoms in patients with plasma cell dyscrasias. This may be due to their quantity in the circulation, to some unusual physicochemical property, or to a biological effect resulting in interaction with other serum proteins. Detection of antibody-combining activity in myeloma proteins has led to important new information on combining-site structure and the kinetics of antigen-antibody-combining activity. Some antibody-combining specificities seem to be present in a higher than expected frequency. As yet, no major therapeutic advances have followed this more precise characterization of the paraprotein, though some interesting possibilities have been explored in animal models.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000912:Antibodies, Neoplasm; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody; D001859:Bone Neoplasms / Q000097:blood / Q000276:immunology*; D004195:Disease Models, Animal; D000939:Epitopes; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007700:Kinetics; D051379:Mice; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology*; D009194:Myeloma Proteins / Q000032:analysis / Q000276:immunology*; D011817:Rabbits
chemical_list: D000912:Antibodies, Neoplasm; D000939:Epitopes; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009194:Myeloma Proteins