Luminal alkalinization by guinea-pig cecum in vitro, an electro-neutral process.
Guinea-pig cecum was found to alkalinize its mucosal media in vitro at a chemical equivalents rate greater than the short circuit current (ISC). Alkalinization was inhibited by conditions which did not affect ISC and by low mucosal Na suggesting an electro--neutral process, dependent on Na.
D000086:Acetazolamide / Q000494:pharmacology; D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D002432:Cecum / Q000502:physiology*; D002794:Choline / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008564:Membrane Potentials; D012964:Sodium / Q000494:pharmacology
D004140:Dinitrophenols; D012964:Sodium; D002794:Choline; D000086:Acetazolamide