Studies on T and B lymphocytes in the peripheral blood of discoid lupus erythematosus patients with and without chloroquine treatment.
The proportions of T-B cells of peripheral lymphocytes in DLE patients as well as the effect of chloroquine treatment on T cell count were studied. In DLE, both the active and the total rosette-forming cell counts decreased, whereas the B cell count did not differ from normal values. Long-term chloroquine administration causes a further reduction in T cell count.
D001402:B-Lymphocytes / Q000276:immunology*; D002738:Chloroquine / Q000627:therapeutic use*; D006801:Humans; D007104:Immune Adherence Reaction; D007958:Leukocyte Count; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D002738:Chloroquine