Galactorrhea and the defective luteal phase of the menstrual cycle.
Twelve patients with primary infertility due to a defective luteal phase associated with hyperprolactinemia and galactorrhea are reported. All were treated with 2-bromoergocryptine. During the first cycle of therapy, the serum prolactin level decreased in all cases, and galactorrhea disappeared during the second cycle of therapy. Seven women responded to 2-bromoergocryptine, as was reflected in their endometrial biopsies. The remaining five were given clomiphene citrate on the second and sixth days of the next 2-bromoergocryptine cycle. Three of these patients responded favorably to this combined therapy. Six pregnancies were reported during therapy. The results of follow-up after labor or abortion suggested that these cases represent a latent stage of the amenorrhea-galactorrhea syndrome.
D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005687:Galactorrhea / Q000150:complications*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology*; D007775:Lactation Disorders / Q000150:complications*; D008183:Luteal Phase; D008599:Menstruation Disturbances / Q000150:complications* / Q000188:drug therapy; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*
D002996:Clomiphene; D001971:Bromocriptine; D011388:Prolactin