Direct inhibition of gastric acid and pepsin secretion by growth-hormone release-inhibiting hormone in cats.
Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.-R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.
D000821:Animal Feed; D000818:Animals; D002415:Cats; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D007263:Infusions, Parenteral; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D010434:Pepsin A; D010418:Pentagastrin