Antimicrobial activity of chloramphenicol in solid dispersion systems.
The effect of solid dispersion techniques on the antimicrobial activity of chloramphenicol has been studied and it was proven that the antimicrobial activity of chloramphenicol is not affected when the drug is present as a coprecipitate with carbowaxes (4.000, 6.000, 12.000), and PVP 11.000 and 40.000) also in fusion systems with these polymers. In contrast, the antimicrobial activity of the drug is enhanced when it is present in the from of a solid dispersion system.
D002701:Chloramphenicol / Q000494:pharmacology*; D004304:Dosage Forms; D004926:Escherichia coli / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration
D004304:Dosage Forms; D002701:Chloramphenicol