Hydrodynamic analog model for pharmacokinetics II: critical examination of model and its contribution to pharmacokinetics.
A comparison of the conventional pharmacokinetic models and the previously proposed hydrodynamic diffusion analog model is presented. A significant result that an n-compartment system can exhibit at best (n - 1) extremum times in the concentration-time plot of the central compartment under appropriate values of physiological parameters is presented. The observation of kinks experimentally in certain physiological-drug systems is thus shown to be amenable to explanation.
D001728:Dicumarol; D004058:Diffusion; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D004364:Pharmaceutical Preparations; D001728:Dicumarol