Inhibitory effect of 5-hydroxytryptamine on lipogenesis in rat adipose tissues.
5-Hydroxytryptamine (5-HT) inhibited the incorporation of 14C from 14C-labelled glucose, pyruvate, citrate and acetate into fatty acids but it did not inhibit the conversion of 14C from citrate and acetate into CO2, and the citrate conversion into glyceride-glycerol in epididymal and mesenteric adipose tissue from 24h-fasted rats. 5-HT stimulated the formation of lactate from glucose and pyruvate, and increased the ratio of lactate produced/pyruvate taken up. This ratio was similar to the NADH:NAD ratio. These results indicate that 5-HT inhibits fatty acid synthesis in rat white adipose tissue by mechanisms similar to those of the catecholamines.
D000085:Acetates / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002951:Citrates / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D000085:Acetates; D002951:Citrates; D005227:Fatty Acids; D008055:Lipids; D011773:Pyruvates; D012701:Serotonin; D000255:Adenosine Triphosphate; D005947:Glucose