[Experience in the treatment of islet adenomas (author's transl)].
The clinical picture of insulinomas is discussed with reference to the literature and 27 of our own cases. The neurological symptoms are usually more prominent, so that the diagnosis is delayed. The average delay between the onset of the disease and its recognition was 4 years. Whipple's triad is characteristic of insulinoma. Of the chemical laboratory investigations, the hunger and tolbutamide tests are the most reliable for the diagnosis. Because of the danger of brain damage, there is an absolute indication for operation. Conservative treatment is burdened with numerous side effects so that it is only considered as a temporary measure or for inoperable patients. In the overwhelming majority of cases, enucleation of the tumors from the pancreas is successful. The cure rate after successful operation is about 80%.
D007516:Adenoma, Islet Cell / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001925:Brain Damage, Chronic / Q000209:etiology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006815:Hunger; D006946:Hyperinsulinism / Q000150:complications / Q000209:etiology; D007414:Intestinal Neoplasms / Q000601:surgery; D007583:Jejunum; D008297:Male; D008875:Middle Aged; D009461:Neurologic Manifestations; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D014044:Tolbutamide
D001786:Blood Glucose; D014044:Tolbutamide
Erfahrungen in der Behandlung von Inselzelladenomen