title: Serum antithrombin in coronary-artery disease.
abstract: Serum antithrombin activity (AA) was correlated with coronary angiographic findings in 69 patients with documented angina. There was excellent correlation between normal values and normal coronary circulation or only one-vessel stenosis in 30 of 35 patients (86%). When AA was above 90%, 90% of patients (20 of 22) had normal circulation or one-vessel occlusion. In 24 patients AA values were significantly decreased. Coronary angiography in this group revealed three with normal circulation or only one-vessel involvement (10%); 21 of 24 had two or three vessels occluded (90%). The correlation between severe CAD and low AA is probably coincidental to a "triggered" or "turned-on" clotting system. The most practical clinical contribution of AA estimation relates to this capacity to identify angina patients in whom clot-preventive measures (aspirin; dipyridamole; anticoagulants) might prove beneficial.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000991:Antithrombins / Q000097:blood*; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014361:Trypsin Inhibitors / Q000097:blood; D000511:alpha-Macroglobulins / Q000097:blood
chemical_list: D000991:Antithrombins; D014361:Trypsin Inhibitors; D000511:alpha-Macroglobulins