Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension.
1. Hypertension was induced in rats by renal artery clip with the contralateral kidney removed (Goldblatt I) or left intact (Goldblatt II). 2. Plasma noradrenaline was increased 62% in the Goldblatt I animals after 3 weeks. 3. Hypothalamic tyrosine hydroxylase and dopamine beta-hydroxylase activities, and the concentration of noradrenaline were increased in the Goldblatt I animals after 3 weeks. 4. Enhanced hypothalamic noradrenaline synthesis may be a pathogenic factor in Goldblatt I renovascular hypertension.
D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D006977:Hypertension, Renal / Q000378:metabolism*; D006978:Hypertension, Renovascular / Q000378:metabolism* / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine