title: The effects of nitrilotriacetic acid on solubilities of zinc, copper, manganese, and iron in the stomach of sheep.
abstract: Four sheep, each prepared with a rumen fistula and reetrant cannula in the proximal duodenum, were used to study the effects of ruminal administration of nitrilotriacetic acid on solubilities of zinc, copper, manganese, and iron in rumen and duodenal digesta. The sheep received a pelleted diet and were dosed with 0, 300, 600 and 1200 microgram of nitrilotriacetic acid per gram of diet via the rumen fistula. Higher concentration of soluble zinc, manganese, and iron but not copper, were found in the rumen of the sheep when they were dosed with nitrilotriacetic acid. The concentrations increased with increasing dose of the acid. However, only the solubilty of iron was increased in the duodenal digesta. Concentrations of soluble zinc and manganese in the rumen increased, whereas copper decreased, during the first 2 h after feeding. The pattern was reversed thereafter. Changes in the concentrations of soluble during 6 h afther feeding were comparatively small. It is concluded that the solubilty of iron in the stomach of sheep is increased by ruminal administration of nitrilotriacetic acid.
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D003300:Copper; D004032:Diet; D004386:Duodenum / Q000502:physiology; D005753:Gastric Mucosa / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007501:Iron; D008297:Male; D008345:Manganese; D008670:Metals / Q000378:metabolism*; D009571:Nitrilotriacetic Acid / Q000494:pharmacology*; D012417:Rumen / Q000502:physiology; D012756:Sheep; D012995:Solubility; D013997:Time Factors; D015032:Zinc
chemical_list: D000085:Acetates; D008670:Metals; D008345:Manganese; D003300:Copper; D007501:Iron; D015032:Zinc; D009571:Nitrilotriacetic Acid