In-vitro inhibition of RNA-instructed DNA polymerase.
Rifamycins and distamycins were assayed in vitro for their effects on the activity of a reverse transcriptase derived from the plasma of a patient with breast cancer. The inhibitory effect observed was compared with that of a human placental substance with a molecular weight of approximately 10 000. The latter substance is apparently also capable of affecting reverse transcriptase activity in vitro.
D001943:Breast Neoplasms / Q000201:enzymology; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors* / Q000097:blood; D004214:Distamycins / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012313:RNA; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins / Q000494:pharmacology; D013942:Thymine Nucleotides / Q000378:metabolism
D004214:Distamycins; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins; D013942:Thymine Nucleotides; D012313:RNA; D004254:DNA Nucleotidyltransferases