[Tetrahydropyridoazepine and tetrahydropyridoazepinone derivatives. I. Derivatives of 2,3,4,5-tetrahydro-1H-pyrido[3,2b]azepine and of the corresponding lactam].
Preparation of N-derivatives of 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepine and, in one case, of 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepine-2-one was achieved by introducing the substituents COCl, CONH2, CO2(CH2)3N(CH3)2, COCH2Br and (CH2)3N(CH3)2. The pharmacological results indicate some effect on the ANS.
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000138:chemical synthesis; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D008722:Methods; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000970:Antineoplastic Agents; D001381:Azepines; D006633:Histamine Antagonists; D010276:Parasympatholytics
Dérivés de tétrahydropyridoazépines et de tétrahydropyridoazépinones. I - Dérivés de la tétrahydro-2,3,4,5 1H-pyrido[3,2-b]azépine et du lactame correspondant.