Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis.
Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein-induced (secondary) amyloid fibrils. This antiserum to the amyloid fibril protein AA (mol wt 8,400 daltons) detects an immunologically cross-reacting serum alpha globulin (SAA) (mol wt approx. 100,000). It is postulated that the serum factor (SAA) is a regulator of antibody response and may be present in elevated amounts as the result of chronic antigenic stimulation.
D000510:Alpha-Globulins; D000682:Amyloid / Q000276:immunology; D000686:Amyloidosis / Q000139:chemically induced / Q000276:immunology*; D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D002364:Caseins; D002470:Cell Survival; D002478:Cells, Cultured; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D013154:Spleen / Q000276:immunology
D000510:Alpha-Globulins; D000682:Amyloid; D000906:Antibodies; D002364:Caseins