title: [Precurarization using pancuronium in male subjects. Evaluation of certain clinical effects].
abstract: The authors studied certain effects in the male subject of precurarisation using different doses of pancuronium. The results obtained show that the maximum doses used, corresponding to 0.01 Omg/kg of pancuronium, were associated with subjective symptoms which were well tolerated by the conscious patient, a decreases in the incidence of fasciculations, antagonistic effects against succinylcholine and a decreases in postoperative myalgia. In their conclusion, the authors confirm that the maximum doses of pancuronium used require an increase in doses of succinylcholine in order to avoid the antagonism phenomenon, and that doses ranging from 0.010 to 0.020 mg/kg of pancuronium could be used in order to completely eliminate postoperative myalgia related to succinylcholine.
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005221:Fatigue / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009135:Muscular Diseases / Q000517:prevention & control; D010149:Postoperative Pain / Q000517:prevention & control; D010197:Pancuronium / Q000008:administration & dosage / Q000494:pharmacology*; D013390:Succinylcholine / Q000037:antagonists & inhibitors*; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D013390:Succinylcholine; D010197:Pancuronium
vernacular_title: La précurarisation par pancuronium chez le sujet de sexe masculin. Evaluation de certains effets cliniques.