New familial defect in microbicidal function of polymorphonuclear leucocytes.
A family is described in which a defect in intracellular killing affected two, and probably three, siblings of both sexes. From an early age they have had recurrent severe infections. During these episodes their white-blood-cell count became very high. This familial disorder seems to differ from previously reported syndromes of abnormal leucocyte function.
D000293:Adolescent; D000328:Adult; D001770:Blood Bactericidal Activity; D002648:Child; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007109:Immunity; D007962:Leukocytes / Q000276:immunology / Q000502:physiology*; D007964:Leukocytosis / Q000235:genetics; D008297:Male; D009895:Opsonin Proteins; D010375:Pedigree; D010587:Phagocytosis; D013211:Staphylococcus aureus
D006680:HLA Antigens; D009895:Opsonin Proteins