The reconstruction of a fragment of primordial genetic information from modern proteins: PGI-FI (AHAP).
In a continuation of earlier studies the connection between a reconstructed ancestral histone IV peptide and various sequences from non-histone proteins was investigated. This peptide, AHAP, was found to be related to partial peptides from the human encephalitogenic protein, immunoglobulin L-chains, fibrinopeptide A, glyceraldehyde-3-phosphate-dehydrogenase, TMV coat protein and several other proteins and protein families; for comparison, nodal sequences were employed wherever possible. The widespread occurrence of genetic information expressed in AHAP caused us to rename the peptide PGI-FI (primordial genetic information-fragment 1) since this peptide is apparently part of a very primitive and ancient genetic information, and may be called "protogene".
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D003026:Clupeine / Q000032:analysis; D005344:Fibrinopeptide A / Q000032:analysis; D006657:Histones / Q000032:analysis*; D008967:Molecular Biology; D004676:Myelin Basic Protein / Q000032:analysis; D010455:Peptides / Q000032:analysis*
D000596:Amino Acids; D006657:Histones; D004676:Myelin Basic Protein; D010455:Peptides; D005344:Fibrinopeptide A; D003026:Clupeine