Depletion of brain noradrenaline, but not dopamine, by intracerebral 6-hydroxydopamine potentiates convulsions induced by electroshock.
Intracerebral injection in rats of 4 microgram of the catecholamine neurotoxin 6-hydroxydopamine was used to deplete forebrain noradrenaline to less than 10% of control values and separately to deplete brain dopamine to less than 15% of control. The susceptibility of these animals to electroconvulsive shock-induced convulsions was examined, and a significant potentiation of the response was seen in the rats depleted of noradrenaline but not in those depleted of dopamine. The duration of the convulsion was significantly increased as a result of loss of forebrain noradrenaline.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004597:Electroshock; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D012640:Seizures / Q000503:physiopathology*
D006892:Hydroxydopamines; D004298:Dopamine; D009638:Norepinephrine