title: Rauwolfia derivatives and breast cancer. A case/control study in Olmsted County, Minnesota.
abstract: In response to three reports of an association between rauwolfia derivatives and breast cancer, a case/control study was undertaken in Olmsted County, Minnesota. Comparison of a cohort of women with breast cancer to an age-match cohort of women with cholelithiasis failed to show any meaningful differences in the two groups except with respect to a history of hypertension. The rates of use of rauwolfia derivatives by hypertensive cases and controls were identical--which, along with other considerations, leads to the conclusion that an association between the use of rauwolfia derivatives and breast cancer is unlikely.
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001824:Body Constitution; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D002986:Clinical Trials as Topic; D004522:Educational Status; D005191:Family Characteristics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008875:Middle Aged; D008910:Minnesota; D010298:Parity; D046948:Secologanin Tryptamine Alkaloids / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D046948:Secologanin Tryptamine Alkaloids