Combination of meprobamate and diphenhydramine treatment increases tyrosine hydroxylase activity in the nucleus locus coeruleus.
The combination of meprobamate and diphenhydramine increased tyrosine hydroxylase activity in the rat nucleus locus coeruleus after twice daily injections, whereas neither compound alone had an effect. Increased activity occurred using a variety of medication ratios and absolute doses.
D000818:Animals; D004155:Diphenhydramine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D008125:Locus Coeruleus / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008620:Meprobamate / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D004155:Diphenhydramine; D008620:Meprobamate; D014446:Tyrosine 3-Monooxygenase