[Effect of butyrophenone derivatives on D-serotonin reactive structures].
Droperidol, haloperidol and azabutyron inhibit the reactions of rabbit aortal stria caused by stimulation of D-type serotonine receptors. Droperidol appears most active in this respect. Its antiserotonine properties are characterised by certain selectivity. The capacity of droperidol for protection of D-receptors against irreversible dibenamine blockade suggests its indirect interaction with D-receptors.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000187:drug effects; D002090:Butyrophenones; D004336:Drug Antagonism; D005260:Female; D066298:In Vitro Techniques; D011817:Rabbits; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists; D014599:Uterus / Q000187:drug effects
D014150:Antipsychotic Agents; D002090:Butyrophenones; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin
Vliianie proizvodnykh butirofenona na D-serotoninoreaktivnye struktury.