Antigenic relationship between the surface antigens of avian and equine influenze viruses.
Influenza virus Equine 1 (A/equine/Prague/56) has a hemagglutinin which is antigenically related to the hemagglutinin of fowl plague virus strain Rostock (FPV) and a neuraminidase which cross-reacts with the enzyme of virus N (A/chick/Germany/49). After a single injection of chickens with Equine 1 virus no hemagglutination inhibiting (HI) and neutralizing antibodies against FPV can be demonstrated, although the birds are fully protected against a lethal dose of FPV. HI and neutralizing antibodies against FPV appear after a second injection of Equine 1 virus several weeks after the first one. Liberation of newly sunthesized FPV from the host cell is ingibited by antibodies cross-reacting with any antigen of virus surface.
D000818:Animals; D000956:Antigens, Viral / Q000008:administration & dosage; D001666:Binding Sites, Antibody; D000939:Epitopes; D007240:Equartevirus / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006382:Hemadsorption; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006389:Hemagglutinins, Viral / Q000302:isolation & purification; D009980:Influenza A virus / Q000276:immunology*; D007275:Injections, Intravenous; D009439:Neuraminidase / Q000032:analysis; D009500:Neutralization Tests; D012328:RNA Viruses / Q000276:immunology*; D010948:Viral Plaque Assay
D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D009439:Neuraminidase