[Tuberculous meningitis and antibody deficiency disease (author's transl)].
A 13 year old girl not vaccinated with BCG became ill with tuberculous meningitis. After administration of 30 g of Streptomycin, cell counts and protein concentrations of the cerebro-spinal fluid returned to normal values. After continuation of antituberculous therapy without Streptomycin, the patient relapsed, and Streptomycin had to be given for 14 months. Defect in humoral immunity was diagnosed with low IgG and low titers of antiviral antibodies. For this reason the patient was additionally treated with passive administration of antibodies.
D000293:Adolescent; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid; D000995:Antitubercular Agents / Q000009:adverse effects*; D004977:Ethambutol / Q000009:adverse effects; D005260:Female; D006801:Humans; D017099:IgG Deficiency; D012008:Recurrence; D013307:Streptomycin / Q000627:therapeutic use; D014390:Tuberculosis, Meningeal / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005719:gamma-Globulins / Q000627:therapeutic use
D000914:Antibodies, Viral; D000995:Antitubercular Agents; D005719:gamma-Globulins; D004977:Ethambutol; D013307:Streptomycin
Tuberkulöse Meningitis und Antikörpermangelsyndrom