Ganglionic blocking effect of some antibiotics on isolated rat sympathetic ganglion.
It was shown on the isolated superior cervical ganglion of the rat that some antiobiotics exerted a blocking effect nearly as potent as that exhibited by hexamethonium or d-turbocurarine. The ganglionic blockade thus induced proved to be non-specific and due to the local anaesthetic effect of the tested drugs.
D000779:Anesthetics, Local; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005260:Female; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000502:physiology; D005730:Ganglionic Blockers; D066298:In Vitro Techniques; D008297:Male; D009333:Neck; D009431:Neural Conduction / Q000187:drug effects; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects
D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents; D005730:Ganglionic Blockers