title: Pharmacokinetics and tolerability of a single oral 600-mg dose of doxycycline.
abstract: The pharmacokinetics of a single orally administered 600-mg dose of doxycycline (six 100-mg film-coated tablets) was studied in 18 healthy subjects. Plasma doxycycline levels remained above 1.35 mumol/L for 48 hours and compared favourably with the mean inhibitory concentrations of doxycycline against the common infecting organisms in chronic bronchitis. In a separate tolerability study in 37 healthy subjects, there was no significant difference between doxycycline and placebo in the incidence of adverse effects.
mesh_terms: D000328:Adult; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D004361:Drug Tolerance; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D004318:Doxycycline