3alpha-Reduction of dihydrotestosterone in human normal and hypertrophic prostatic tissues.
The activity of 3alpha-reduction of dihydrotestosterone was located in both the particulate and the soluble fractions of human prostatic tissues. Activity of 3alpha-reduction was higher than that of 3beta-reduction under the incubation conditions employed; therefore, the main reductive metabolic pathway of dihydrotestosterone seemed to be the formation of 5alpha-androstane-3alpha,17beta-diol in human prostatic tissues. There was no significant difference between normal and hypertrophic prostatic tissues when the activity of 3alpha-reduction of dihydrostertosterone was compared on a wet weight basis.
D000368:Aged; D000731:Androstanes / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism*; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*
D000731:Androstanes; D013196:Dihydrotestosterone