Functional aspects of the superoxide dismutative action of Cu-penicillamine.
The superoxide dismutative action of Cu-penicillamine was examined by pulse radiolysis. The second order rate constand of the reaction wpith superoxide was 0.4 +/- o.2.10(9) M-1.s-1, comparable to the action of Fe and Mn-superoxide dismutases. No marked pH-dependence was seen. Neither ethylene diamine tetraacetic acid nor cyanide affected the catalytic action of Cu-penicillamine. The cyanide resistant reactivity as well as further X-ray photoelectron spectrometric measurements supported the suggestion of a Cu(I) stabilized sulphur radical being the active species involved in the catalysis of superoxide dismutation.
D001665:Binding Sites; D003300:Copper / Q000378:metabolism*; D003486:Cyanides / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005029:Ethylenediamines / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010396:Penicillamine / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism; D013861:Thiocyanates / Q000378:metabolism
D003486:Cyanides; D005029:Ethylenediamines; D013861:Thiocyanates; D013481:Superoxides; D003300:Copper; D004492:Edetic Acid; D013482:Superoxide Dismutase; D010396:Penicillamine