title: beta-Adrenoceptor blocking effects and pharmacokinetics of pindolol. A study in hypertensive Africans.
abstract: The beta-adrenoceptor blocking effects of pindolol were compared with those of a placebo in a double-blind trial in twelve hypertensive Africans. Heart rate and arterial blood pressure were measured at rest and immediately after exercise, before and at intervals up to 8 h after oral administration of the drugs. Plasma levels of pindolol were also determined. Pindolol reduced systolic blood pressure and antagonised exercised-induced tachycardia. The mean time to peak level of pindolol was 1.9 h and the mean half-life was 4.2 h. Comparison of plasma levels of pindolol and beta-adrenoceptor blocking activity showed good correlation between them. It is concluded that the pharmacokinetics and beta-blocking effects of pindolol in Africans are not dissimilar from published data for other races.
mesh_terms: D000319:Adrenergic beta-Antagonists; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006207:Half-Life; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D010869:Pindolol / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D010919:Placebos; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D010919:Placebos; D010869:Pindolol