Responses of olfactory bulb neurones to the dipeptide carnosine.
Carnosine has been applied by microiontophoresis ot identified neurones in the olfactory bulb of the rat from solutions of different pH. Although mainly without effect when compared with conventional excitatory and inhibitory amino acids, the dipeptide tended to be depressive when ejected as a cation and excitant when ejected as an anion. The results obtained are not in favour of this substance being an excitatory transmitter in the primary olfactory pathway.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D004558:Electric Stimulation; D006863:Hydrogen-Ion Concentration; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009830:Olfactory Bulb / Q000187:drug effects*; D051381:Rats
D000596:Amino Acids; D004151:Dipeptides; D002336:Carnosine