title: Adverse reactions to drugs in general practice.
abstract: Of 817 patients in a general-practice survey of adverse reactions to drugs, 41% were thought to have "certainly" or "probably" had a reaction to the drug prescribed. Adverse effects on the gastrointestinal and central nervous systems were the most frequently reported, and 90% of reactions had occurred by the fourth day of treatment. More patients given drugs acting on the central nervous system and antihistamines reported reactions than those in other categories. A higher incidence of adverse drug effects is shown in this general-practice survey than in other, mainly hospital-based, surveys. Further intensive surveillance for adverse effects of drugs is recommended to provide additional information on the burden of drug-induced disease in the community.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002491:Central Nervous System Agents / Q000009:adverse effects; D002493:Central Nervous System Diseases / Q000139:chemically induced; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D004739:England; D005194:Family Practice; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006634:Histamine H1 Antagonists / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D002491:Central Nervous System Agents; D006634:Histamine H1 Antagonists