Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation.
The marrow of a dog affected with cyclic neutropenia (CN) was transplanted into an unaffected supralethally irradiated litermate. Prompt engraftment occurred, and cyclic rises and falls in numbers of platelets, reticulocytes, and granulocytes were noted in the recipient soon after engraftment. Prior to transplantation and under hypoxic conditions, the donor had serum erythropoietin (ESF) peak levels at 11-12-day intervals. Following transplatation and under hypoxic conditions, cyclic peaks of ESF occurred in the transplanted dog.
D000380:Agranulocytosis / Q000662:veterinary*; D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D001681:Biological Assay; D001792:Blood Platelets; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004096:Dihydrostreptomycin Sulfate / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D004338:Drug Combinations; D004912:Erythrocytes / Q000378:metabolism; D004921:Erythropoietin / Q000032:analysis; D000860:Hypoxia / Q000097:blood; D007501:Iron / Q000097:blood; D007504:Iron Radioisotopes; D007958:Leukocyte Count; D008727:Methotrexate / Q000627:therapeutic use; D009503:Neutropenia / Q000662:veterinary*; D010507:Periodicity; D011113:Polymyxins / Q000627:therapeutic use; D011828:Radiation Chimera; D012156:Reticulocytes; D014184:Transplantation, Homologous
D004338:Drug Combinations; D007504:Iron Radioisotopes; D011113:Polymyxins; D004921:Erythropoietin; D000667:Ampicillin; D007501:Iron; D004096:Dihydrostreptomycin Sulfate; D008727:Methotrexate