title: The absence of B-cell antigen B2 from leukaemia cells and lymphoblastoid cell lines.
abstract: 60 leukaemia patients with acute mylogenous leukaemia, chronic myelocytic leukaemia, acute lymphatic leukaemia, and chronic lymphocytic leukaemia were tested for five specificities of the new B-lymphocyte alloantigenic system. Two specificities of the first B-cell locus were significantly lower in frequency than in B lymphocytes from 105 controls. B-cell group 1 was found in 18% of leukaemia patients vs. 48% of controls (p less than 0.025) and B-cell group 2 was found in 0% of leukaemia patients vs 23% of controls (p less than 0.025). Group 2 was also absent in 37 cultured lymphoblastoid lines. It is suggested that resistance to B-cell leukaemia and to Epstein-Barr virus transformation in vitro may be linked to a B-lymphocyte specificity on the first B-lymphocyte locus.
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D002648:Child; D008040:Genetic Linkage; D006801:Humans; D007104:Immune Adherence Reaction; D007126:Immunoglobulin Allotypes; D007519:Isoantigens; D007938:Leukemia / Q000235:genetics / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D007951:Leukemia, Myeloid / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology
chemical_list: D007126:Immunoglobulin Allotypes; D007519:Isoantigens