Studies on competitive inflammatory sites. I. Influence of the size of sensitizing skin implants on second-set corneal graft reactions.
A dependence of second-set corneal graft reactions on the size of the sensitizing skin allografts was established in different rat donor-recipient pairs, each of which involved a response to the B2 major histocompatibility antigen. Sensitizing skin sizes larger or smaller than the optimal size were found to result in less intense reaction in subsequently placed second-set corneal allografts. The data obtained support the view that a persisting skin allograft not only sensitizes, but constitutes a competitive inflammatory site. The latter role of a first-set skin allograft may be facilitated by being both more accessible to inflammatory cells and larger than corneal grafts. The relative strength of the sensitizing and competitive effects of a first-set skin allograft apparently influences the fate of a second-set corneal allograft.
D000818:Animals; D001667:Binding, Competitive; D016039:Corneal Transplantation; D006087:Graft vs Host Reaction; D006168:Guinea Pigs; D006648:Histocompatibility; D007249:Inflammation / Q000276:immunology; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D016038:Skin Transplantation; D013997:Time Factors; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous