title: [Action of some gastric antisecretory drugs on histamine H2-receptors (author's transl)].
abstract: A series of compounds endowed with gastric antisecretory activity were examined for their possible effects on histamine H2 receptors in different experimental conditions. The data obtained suggest that, apart from cimetidine, all the other compounds are devoid of antagonistic properties on H2 receptors. The inhibitory effect observed in some of the examined preparations is probably connected with unspecific actions.
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology; D003984:Dibenzazepines / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D011377:Proglumide / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013843:Thiazines / Q000494:pharmacology*; D014299:Trimipramine / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones; D001713:Biphenyl Compounds; D003984:Dibenzazepines; D006635:Histamine H2 Antagonists; D010879:Piperazines; D011437:Propylamines; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D013843:Thiazines; D014299:Trimipramine; D002927:Cimetidine; D006632:Histamine; D011377:Proglumide
vernacular_title: Effetto di alcuni farmaci antisecretori gastrici sui recettori istaminici H2.