title: Changes in rat gastric proteases with age: effect of hydrocortisone.
abstract: Gel filtration on Sephadex G-75 of rat gastric mucosal preparation shows two peaks of proteolytic activity. These peaks differ at different ages of animals. The proteolytic activity of the gastric mucosa is spread over a wider range of pH in younger animals than older ones with a shift from higher pH towards lower pH values with increasing age. Hydrocortisone injection to nine day-old rats results in qualitative changes of gastric mucosal proteases, the proteolytic activity pattern of young treated animals being similar to that of untreated adult rat.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D006854:Hydrocortisone / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007279:Injections, Subcutaneous; D008297:Male; D010447:Peptide Hydrolases / Q000032:analysis*; D051381:Rats
chemical_list: D010447:Peptide Hydrolases; D006854:Hydrocortisone