title: Relevance of "significant bacteriuria" to aetiology and diagnosis of urinary-tract infection.
abstract: 28 of 74 female domiciliary patients who presented with urinary-tract symptoms did not fulfil the usually accepted laboratory criterion required for confirmation of urinary-tract infection (i.e., a urinary bacterial viable count in excess of 100 000/ml). The progress of the disease was similar in non-bacteriuric and bacteriuric patients. In addition, a significant proportion of the bacteriuric group did not show the response to therapy expected from the results of in-vitro tests of antibiotic sensitivity and urinary antibacterial activity. To explain these findings, it is postulated that bacteria may not be primary pathogens in uncomplicated urinary-tract infection even where "significant bacteriuria" is demonstrated.
mesh_terms: D000293:Adolescent; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use; D001437:Bacteriuria / Q000209:etiology*; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000892:Anti-Infective Agents, Urinary