Metabolism of phenothiazine in the guinea pig.
The metabolism of phenothiazine was studied in the guinea pig. In the adult animal after 24 hr, about 7% of the administered dose was found in feces, with traces of the sulfoxide and phenothiazone. Small amounts of all these compounds also were found in urine, with leucophenothiazone sulfate (approximately 12%) and a metabolite identified as phenothiazine N-glucuronide (approximately 22%). This latter compound was also present in bile. Both phenothiazine and its sulfoxide were retained in body tissues for a long time, about 85% of the dose being excreted after 7 days. In neonatal animals, phenothiazine, with up to 12% of the sulfoxide together with traces of leucophenothiazone, phenothiazone, and thionol was excreted in urine.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D006168:Guinea Pigs; D010640:Phenothiazines / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D010640:Phenothiazines