Proceedings: The effects of hypothalamic and reflexogenic hypertension on renal and femoral circulation.
In anaesthetized dogs, electrical stimulation of the median posterior hypothalamus provoked hypertension accompanied by a decrease of renal blood flow and an increase of femoral blood flow. Similar hypothalamic reactions occurred after bilateral cervical vagotomy or after atropine, 2 mg/kg i.v. During reflexogenic hypertension induced by bilateral carotid occlusion in bivagotomized dogs, the renal and femoral blood flows were not significantly modified. The decrease of the renal blood flow and the increase of the femoral blood flow, during hypothalamic stimulation were greatly reduced or reversed after R 28935 equals erythro-1-(1--e12-(1,4-benzodioxan-2-yl)-2-OH-Et]-4-piperidyl)-2-benzimidaxolinone, 80 mug/kg i.v., but not after clonidine, 5 mug/kg i.v.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology; D001783:Blood Flow Velocity; D002346:Carotid Sinus / Q000502:physiology; D003000:Clonidine / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D005263:Femoral Artery / Q000502:physiology*; D006973:Hypertension; D007031:Hypothalamus / Q000502:physiology*; D007668:Kidney / Q000098:blood supply*; D010880:Piperidines / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D014628:Vagotomy
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D004146:Dioxanes; D010880:Piperidines; D001285:Atropine; D003000:Clonidine