Factor VIII and glomerulonephritis.
To find out if determination of factor VIII,which most probably is synthetised in the intima of blood-vessesls, is of value for predicting the severity of vessel damge in glomerulonephritis, factor-VIII activity, factor-VIII-related  antigen, and glomerular filtration-ratewere esto,ated om 85 patients with early glomerulonephritis on admission, and in 70 of these at follow-up for up to 4 years. The levels of factor-VIII activity and factor-VIII-related antigen on admission were normal in those patients who recovered. Where renal function was impaired on admission or becaome so during follow-up, factor VIII  was high. Determination of factor VIII might thus be of prognostic value in early glomerulonephritis.
D000941:Antigens / Q000302:isolation & purification; D001706:Biopsy; D005169:Factor VIII / Q000276:immunology; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000276:immunology / Q000503:physiopathology
D000941:Antigens; D005169:Factor VIII