Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs.
1. In guinea-pigs fed an ascorbic-acid-free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10-12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea-pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic-acid-depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea-pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D000818:Animals; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism; D012614:Scurvy / Q000378:metabolism*
D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D001205:Ascorbic Acid