HLA and pancreatic islet cell antibodies in diabetes.
The frequency of HLA-B8 was significantly increased in pancreatic islet cell antibody (P.I.C.A)-positive patients (61%) compared with P.I.C.A.-negative patients (35%) and a control population (28%). This increased frequency of HLA-B8 was even more striking in diabetics in whom P.I.C.A. persisted for more than 5 years (71%). Thus the association of HLA-B8 with diabetes may be related to the presence of P.I.C.A. in these patients.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000302:isolation & purification*; D002648:Child; D003920:Diabetes Mellitus / Q000235:genetics / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000302:isolation & purification; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*
D001323:Autoantibodies; D006680:HLA Antigens