In vivo and in vitro effect of cyclophosphamide on Borrelia duttoni.
Sera taken from mice given cyclophosphamide 75 min previously fails to substantially inhibit borrelial multiplication in vitro. Mice given cyclophosphamide were infected with Borrelia duttoni. Inability to demonstrate specific antibody in these mice did not prevent recovery from infection, resolution of the bacteraemia or appearance of an antigenic variant. Cyclophosphamide may delete suppressor lymphocytes allowing enhanced production of antibodies which may not only protect, but induce antigenic variation. Alternatively, recovery from infection may be unrelated to the immune response.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects; D001769:Blood / Q000382:microbiology; D001898:Borrelia / Q000187:drug effects* / Q000276:immunology; D001899:Borrelia Infections / Q000276:immunology* / Q000382:microbiology; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology*; D051379:Mice
D000907:Antibodies, Bacterial; D003520:Cyclophosphamide