Potentiation of the diabetogenic effect of streptozocin by phentolamine in the rat.
The effect of alpha- and beta-adrenoceptor blocking agents and a beta2-agonist, salbutamol, on the diabetogenic effects of streptozocin (threshold doses) was investigated in the rat. Phentolamine and salbutamol potentiated the diabetogenic effect of streptozocin but phenoxybenzamine, tolazoline, oxprenolol and propranolol were without effect. The potentiating effect of phentolamine was blocked by oxprenolol. Potentiation of the diabetogenic effect by phentolamine is not related to alpha-adrenoceptor block, vasodilatation or insulin release. But it may be related to its ability to stimulate beta-adrenoceptors.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D010096:Oxprenolol / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology*; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*
D001786:Blood Glucose; D010096:Oxprenolol; D013311:Streptozocin; D010646:Phentolamine