HLA antigens and atopic features in steroid-responsive nephrotic syndrome of childhood.
Atopic systems were more common in children with steroid-responsive nephrotic syndrome (S.R.N.S.) than in matched controls, and HLA-B12 was more common in children with S.R.N.S. than in adult controls. Atopic symptoms (particularly hayfever), positive prick tests with grass pollen antigens, and a higher mean serum concentration of IgE antibody to timothy grass pollen were more common in nephrotic children with HLA-B12 than in those without HLA-B12. There was also an increased frequency of the haplotype HLA-A1 and HLA-B8, mainly among the non-atopic patients.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications* / Q000175:diagnosis; D007073:Immunoglobulin E / Q000302:isolation & purification; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D011058:Pollen; D011239:Prednisolone / Q000627:therapeutic use; D012882:Skin Tests
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007073:Immunoglobulin E; D003520:Cyclophosphamide; D011239:Prednisolone