title: [Circulatory changes during preoperative isovolaemic haemodilution with a mixed solution of hydroxyethyl starch and 5% human albumine. A clinical study (author's transl)].
abstract: The influence of preoperative isovolaemic haemodilution on the circulation was examined in a clinical study. Heart rate, mean arterial pressure, mean pulmonary arterial pressure, cardiac output as well as haemoglobin and haematocrit values were determined. Stroke volume, total peripheral resistance, and the modified tension-time-index were calculated. A mixture of human albumin 5% and hydroxy-ethyl-starch was used as a solution for dilution. During the dilution phase the cardiac output increased compensatorily to the decrease of haemoglobin and the haematocrit values. While the heart rate and the mean arterial pressure remained unchanged the total peripheral resistance was reduced. Considering the described conditions and contraindications, preoperative isovolaemic haemodilution is a suitable method to replace an intraoperative blood loss of up to 2000 ml autologously. Thus a posttransfusion hepatitis can be avoided. In addition, preoperative isovolaemic hemodilution improves the microcirculation and may have a prophylactic effect on the thrombosis in the postoperative phase.
mesh_terms: D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure; D002302:Cardiac Output; D006400:Hematocrit; D006505:Hepatitis / Q000517:prevention & control; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D011300:Preoperative Care; D012709:Serum Albumin / Q000494:pharmacology*; D013213:Starch / Q000031:analogs & derivatives*; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D012709:Serum Albumin; D013213:Starch
vernacular_title: Kreislaufveränderungen bei Präoperativer Isovolämischer Hämodilution mit einer gemischten Lösung aus Hydroxyäthylstärke und Humanalbumin 5%