[General pharmacologic properties of silybine and silymarine in the rat].
Silybine is the main active substance of the polyhydroxyphenylchromanone derivatives extracted from the seeds of Silybum Marianum. In the normal albinos rat, this pure compound (from 2 mg/100 g) lowers directly the systemic blood pressure. It does not increase vascular permeability. It potentiates post-serotonine hypertension. Silybine antagonizes cutaneous oedemas and suppresses the fall of blood pressure induced by dextran polymers. It inhibits anaphylactic shock in rats sensitized by ovalbumine. Silybine seems to be a stabilizer of mastcells membranes, thus preventing histamine release.
D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D003911:Dextrans / Q000037:antagonists & inhibitors; D005419:Flavonoids / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D051381:Rats; D012838:Silymarin / Q000494:pharmacology*
D003911:Dextrans; D005419:Flavonoids; D006634:Histamine H1 Antagonists; D012838:Silymarin
Propriétés pharmacologiques générales de la silybine et de la silymarine chez le rat