Plasma cell granulomas in non-lipemic xanthomatosis: apparent induction by indomethacin.
A 71-year-old man with non-lipemic, generalized, plane xanthomas developed nodules and tumors within one month of starting indomethacin therapy. These enlarged and spread during 5 months of daily indomethacin but promptly and spontaneously involuted when the indomethacin was discontinued. Within 4 months, the nodules and tumors were completely gone. The process is viewed as an "indoderma", i.e. a granulomatous drug reaction, analogous to an iododerma.
D000368:Aged; D001772:Blood Cell Count; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010146:Pain; D010950:Plasma Cells; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014973:Xanthomatosis / Q000139:chemically induced* / Q000473:pathology
D007213:Indomethacin