Absence of noxious effects of selected neuroleptics in dominant-lethal mutagenesis assay.
In a dominant-lethal assay in mice the following tricyclic neuroleptics were tested: prothiaden, imipramine, oxyprothepin decanoate and docloxythepin. No dominant-lethal effect was induced by these neuroleptics, even when administered at doses many times as great as clinical doses. The reduced percentages of pregnancies, in females who had copulated with males receiving docloxythepin, observed during and immediately after its administration, were directly connected with marked sedation induced in the males by this neuroleptic.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003988:Dibenzothiepins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004308:Dothiepin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009153:Mutagens
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D009153:Mutagens; C019360:docloxythepin; D007099:Imipramine; D004308:Dothiepin