Cardiorespiratory assessment of decongestant-antihistamine effects on altitude, +Gz, and fatigue tolerances.
Decongestants and antihistamines are known to produce effects capable of adversely modifying physiological function and psychomotor task performance. Because of relevance to safe pilot performance, the effects of single doses of two decongestant-antihistamine preparations (Compound A and Compound B), or a placebo on cardiorespiratory responses to two equally spaced +2 Gz tests during separate 2-h exposures at 388 m (1,274 ft MSL) ground level (GL) and 3,810 m (12,500 ft) chamber altitude were assessed. Post-altitude fatigue was assessed by cardiorespiratory responses to submaximal bicycle ergometry. Compound A and Compound B appeared to exert no significant detrimental effects on short-duration post-altitude ergometric fatigue-ability. With two exceptions, all combinations of medication, altitude, and +Gz were well tolerated. Two subjects were clearly incapacitated during the first +2 Gz test under Compound A at 3,810 m (12,500 ft) altitude. It is felt that the +Gz-intolerance resulted mainly from an adverse interactive effect of Compound A and altitude on vasomotor and/or chronotropic mechanisms.
D000328:Adult; D000531:Altitude; D004338:Drug Combinations; D004809:Ephedrine / Q000009:adverse effects / Q000494:pharmacology; D006804:Ergonomics; D005221:Fatigue / Q000503:physiopathology*; D006112:Gravitation; D006439:Hemodynamics / Q000187:drug effects*; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007192:Indenes / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D004366:Nonprescription Drugs; D010656:Phenylephrine / Q000009:adverse effects / Q000494:pharmacology; D010919:Placebos; D011725:Pyridines / Q000009:adverse effects / Q000494:pharmacology; D014311:Triprolidine / Q000009:adverse effects / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000494:pharmacology*
D004338:Drug Combinations; D006634:Histamine H1 Antagonists; D007192:Indenes; D004366:Nonprescription Drugs; D010919:Placebos; D011725:Pyridines; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D014311:Triprolidine; D004809:Ephedrine