Peripheral catecholamines and memory: characteristics of syrosingopine-induced amnesia.
The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002395:Catecholamines / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology*; D013997:Time Factors
D002395:Catecholamines; D012110:Reserpine; D004298:Dopamine; D009638:Norepinephrine