Reappearance of alpha-fetoprotein in spontaneous hepatitis in the rat.
Reappearance of AFP was demonstrated in a single rat out of a large control population. At autopsy, this DOCA-hypertensive rat was found to have a form of hepatitis associated with proliferative activity, i.e., cellular unrest, mitotic figures and oval cell hyperplasia. It is submitted that increased AFP synthesis in this animal with spontaneous hepatitis is causally related to hepatocellular regeneration.
D000818:Animals; D003900:Desoxycorticosterone / Q000009:adverse effects; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D006520:Hepatitis, Animal / Q000097:blood* / Q000150:complications / Q000473:pathology; D006973:Hypertension / Q000139:chemically induced / Q000150:complications / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000009:adverse effects; D000509:alpha-Fetoproteins / Q000032:analysis*
D005326:Fetal Proteins; D000509:alpha-Fetoproteins; D003900:Desoxycorticosterone; D012965:Sodium Chloride