[Derivatives of 2,3,4,5,-tetrahydro-1H-pyrido-(3,2-b)azepine and 2,3,4,5-tetrahydro-1H-pyrido(2,3-b)azepine and their corresponding lactams. II. Synthesis and pharmacologic study of their psychotropic activity].
Preparation of the N-(2-diethylaminoethyl) derivatives of lactam (II) and of the N-(3-dimethylaminopropyl) derivative of lactam (XI) is described. Synthesis of the N-[4-(2-hydroxyethyl)piperazinylacetyl]- and 1-carbothiamide derivatives of azepine (I) and of the n-(chloroformyl)- and N-(carbamoyl) derivatives of azepine (XII) are also described. Some pharmacological results indicate a partial tranquilizing activity.
D000818:Animals; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005247:Feeding Behavior / Q000187:drug effects; D006168:Guinea Pigs; D006635:Histamine H2 Antagonists; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis*
D001381:Azepines; D006635:Histamine H2 Antagonists; D011619:Psychotropic Drugs
Derivés de la tétrahydro-2,3,4,5 1H-pyrido[3,2-b]azépine, de la tétrahydro-2,3,4,5 1H-pyrido[2,3-b]azépine et de leurs lactames correspondants. II. Synthèse et étude pharmacologique de leur activité psychotrope.