[Pharmaco-kinetic aspects of protein-binding (author's transl)].
Binding of drugs to plasma proteins will influence distribution and elimination especially if factors interfere altering the extent of binding. These factors are: dependence on species, age, H+-concentration, speed of i.v. injection or the interaction of another drug for instance. Considering the quantitative aspects changes in binding to the plasma proteins will turn only then relevant to drug action if the extent of alteration is very large or the drugs are bound to a very high degree. But the scene changes completely if the binding to other proteins of the organism is considered. Experimental results concerning the binding of drugs to hemoglobin and muscle tissue suggest that this kind of binding is possibly more effective in pharmacokinetics than binding to plasma proteins.
D000367:Age Factors; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle; D004285:Dogs; D004304:Dosage Forms; D004341:Drug Evaluation; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D051379:Mice; D009132:Muscles / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine; D013997:Time Factors
D001798:Blood Proteins; D004304:Dosage Forms; D006454:Hemoglobins; D004364:Pharmaceutical Preparations
Pharmakokinetische Bedeutung der Proteinbindung.