Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals.
Iron--EDTA was shown to catalyse OH. production from H2O2 and ascorbate by a mechanism largely independent of superoxide. When ascorbate and superoxide were both present, the ascorbate mechanism was more important than superoxide as a source of OH., and would appear to be more significantly biologically.
D000447:Aldehydes / Q000378:metabolism; D001205:Ascorbic Acid / Q000378:metabolism*; D005030:Ethylenes / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
D000447:Aldehydes; D005030:Ethylenes; D005609:Free Radicals; D013438:Sulfhydryl Compounds; D009243:NAD; D013481:Superoxides; D009249:NADP; D005978:Glutathione; D001205:Ascorbic Acid; D010100:Oxygen