Effects of some cardioactive drugs on the oxygen affinity of whole blood.
Increasing amounts of Digoxin, Lasix, Teofyllamin and CI-775 were added to human blood in vitro and the whole blood oxygen affinity was measured. We found no definite proof that any of the drugs was able to affect the oxygen affinity of the red cells even at unphysiologically high concentrations.
D000070:Acebutolol / Q000494:pharmacology*; D000628:Aminophylline / Q000494:pharmacology*; D004077:Digoxin / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins; D013806:Theophylline / Q000494:pharmacology*
D010108:Oxyhemoglobins; D000628:Aminophylline; D000070:Acebutolol; D004077:Digoxin; D013806:Theophylline; D010100:Oxygen