Oestrogen receptors in human malignant melanoma.
16 of 35 patients (46%) with malignant melanoma were found to have cytoplasmic oestrogen-receptor activity in biopsy specimens. OEstrogen-receptor activity was detected in primary lesions, lymph-node metastases, skin metastases, and visceral metastases. Equal percentages of males and females had positive assays. Scatchard analysis of binding in one case was consistent with a single class of high affinity receptor sites.
D000328:Adult; D000367:Age Factors; D001665:Binding Sites; D001667:Binding, Competitive; D003593:Cytoplasm; D004958:Estradiol; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000378:metabolism*; D008875:Middle Aged; D011869:Radioligand Assay / Q000379:methods; D011956:Receptors, Cell Surface; D012737:Sex Factors; D012878:Skin Neoplasms / Q000378:metabolism*
D011956:Receptors, Cell Surface; D004958:Estradiol