Antihypertensive effects of intra-cisternal beta-blocking agents in dogs with acute nerogenic hypertension.
Dl-propranolol, acebutolol, atenolol, bupranolol, oxprenolol, pindolol, practolol, sotalol and d-propranolol were injected into the cisterna magna of anesthetized dogs with neurogenic hypertension induced by deafferentation and vagotomy. Dl-propranolol and bupranolol correct the hypertension and the tachycardia of the debuffered dog, whereas oxprenolol has only an action on the heart rate. The other beta-blocking drugs and d-propranolol were inactive at the doses used. Our results show that a mere central effect cannot explain the antihypertensive properties of all the tested beta-blocking agents.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents; D002946:Cisterna Magna; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007267:Injections; D008297:Male; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents