title: Serum protein fractions from children of differing nutritional status analysed by polyacrylamide gel electrophoresis and electroimmunoassay.
abstract: 1. The nutritional status of children showing no clinical signs of malnutrition, from the University School of Khon Kaen, Khon Kaen province, north-east Thailand and from two villages nearby, was tested. The children were grouped according to their body-weight expressed as a percentage of expected weight-for-height (Harvard standards (Stuart & Stevenson, 1959), as given by Jelliffe (1966)). 2. The differing prealbumin concentrations indicated that nutritional status differed between the groups. 3. The urinary urea: creatinine ratio was significantly lower in the village children compared with the children from Khon Kaen, indicative of the higher dietary protein intake of the latter. 4. alpha1-Acid glycoprotein and the first 'post-albumin peak' (obtained by polyacrylamide gel electrophoresis of serum and containing mainly mainly Gc-globulin, alpha1-antichymotrypsin and alpha1-B-glycoprotein) were found to be significantly higher in the village children compared with children from Khon Kaen. 5. The three main proteins of the first 'post-albumin peak' from polyacrylamide gel electrophoresis of serum were tested separately using the electroimmunoassay method. There was no significant difference in Gc-globulin between the children from Khon Kaen and the village children. The concentration of alpha1-B-glycoprotein from those Khon Kaen children whose body-weight was more than 95% expected weight-for-height was significantly lower compared with that of village children, alpha1-Antichymotrypsin concentration was significantly higher in serum from Khon Kaen children than in serum from village children.
mesh_terms: D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000378:metabolism*; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007122:Immunoelectrophoresis; D011228:Prealbumin / Q000378:metabolism; D012424:Rural Population; D013785:Thailand; D014505:Urban Population; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D006023:Glycoproteins; D006454:Hemoglobins; D011228:Prealbumin; D005719:gamma-Globulins; D002918:Chymotrypsin