title: Cocaine: plasma concentrations after intranasal application in man.
abstract: Cocaine (1.5 milligrams per kilogram) was applied to the nasal mucosa of human subjects. The cocaine persisted in the plasma for 4 to 6 hours and reached peak concentrations of 120 to 474 nanograms per milliliter at 15 to 60 minutes. In that residual cocaine was detectable on the nasal mucosa for 3 hours, continuous absorption secondary to its vasoconstrictive action might explain its persistence in the plasma.
mesh_terms: D000281:Administration, Intranasal; D000367:Age Factors; D003042:Cocaine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D007440:Intubation; D014663:Nasal Decongestants; D013997:Time Factors
chemical_list: D014663:Nasal Decongestants; D003042:Cocaine