Cellular co-operation by mouse lymphocytes to chemically defined antigens.
When populations of mouse spleen cells were treated with a highly radioactive 125I-labelled haptenic conjugate (125I-labelled PDG-N) and subsequently injected into X-irradiated, immunized (N-10-C) syngeneic BALB/c mice, it was found that after autoradiography with 125I-labelled N and C haptenic conjugates, the numbers of ABC to both the N and C haptens decreased. The number of ABC found were significantly lower than those found in mice that had been reconstituted with cells "suicided" with another 125I-labelled antigen (125I-labelled BSA) and subsequently immunized with N-10-C.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D000939:Epitopes; D005971:Glutamates / Q000276:immunology; D006241:Haptens; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D005971:Glutamates; D006241:Haptens; D010455:Peptides