title: [Remote results of long-term mercazolyl treatment combined with irradiation of the the hypothalamo-hypophyseal region in patients with diffuse toxic goiter].
abstract: Prolonged mercazolyl therapy (for from 9 months to 10 years) in combination with X-irradiation of the hypothalamo-hypophysial area (sum total dose of 5000 to 15000 rad) led only in 19 of 54 patients with diffuse toxic goiter to normalization of I131 uptake by the thyroid gland and depression of I131 uptake by the thyroid gland in a test with T3, which could indicate recovery from the disease. Despite a stable euthyroid state in 34 of 54 patients there persisted a hyperthyroid type of the curve of I131 uptake by the thyroid gland, and no depression of I131 uptake by the thyroid gland occurred in a test with T3. Thyrotoxicosis relapses were observed in 15 of 34 of the patients of this group. Development of thyrotoxicosis relapses only in the patients in whom pathological tests persisted pointed to the significance of disturbed interrelations in the hypothalamus-hypophysis-thyroid gland system in the genesis of thyrotoxicosis relapses.
mesh_terms: D000328:Adult; D000368:Aged; D013956:Antithyroid Agents / Q000627:therapeutic use*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D014964:X-Ray Therapy
chemical_list: D013956:Antithyroid Agents
vernacular_title: Otdalennye rezul'taty dlitel'nogo lecheniia merkazolilom v sochetanii s oblucheniem gipotalamo-gipofizarnoĭ oblasti u bol'nykh diffuznym toksicheskim zebom