title: Cystic fibrosis: normal volumes of red cells. Model experiments on the pathomechanism of the disease.
abstract: Normal values of mean cell volume (M.C.V.) and of distribution of single cell volumes (S.C.V.) have been observed in erythrocytes of patients with cystic fibrosis using an electronical particle-volume analyzer (sheath flow detector). From these results a strong defect in red cell salt transport seems improbable. Valinomucin induces shrinking (by increase of K+ permeability) and gramicidin D induces swelling (by increase of Na+ permeability) of normal erythrocytes. Addition of C.F. sweat to normal erythrocytes induces no volume change. From this result no influence of the "C.F. factor" on passive ion permeability is concluded.
mesh_terms: D003550:Cystic Fibrosis / Q000097:blood* / Q000503:physiopathology; D004912:Erythrocytes / Q000187:drug effects; D006096:Gramicidin / Q000494:pharmacology; D006801:Humans; D007474:Ion Exchange; D010539:Permeability; D011188:Potassium / Q000502:physiology; D012964:Sodium / Q000502:physiology; D013542:Sweat; D014634:Valinomycin / Q000494:pharmacology
chemical_list: D006096:Gramicidin; D014634:Valinomycin; D012964:Sodium; D011188:Potassium