Clinical tolerance and catabolism of plasmin-treated gamma-globulin for intravenous application.
Plasmin-treated gamma-globulin of placental origin was tested in clinical and laboratory studies and found to be suitable for intravenous use both for prophylactic and therapeutic purposes. Plasmin treatment of gamma-globulin (IgG) results in proteolytic cleavage of 60-70% of the molecules into Fab and Fc fragments whereas 30-40% of the molecules are plasmin resistant. The antibody spectrum of plasmin-treated gamma-globulin is similar to that of standard gamma-globulin. Catabolic properties of the plasmin-resistant portion of this preparation and of standard gamma-globulin are identical. Plasmin-treated gamma-globulin has no anticomplementary activity and its intravenous administration is well tolerated even by highly sensitive immunodeficient patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D001424:Bacterial Infections / Q000628:therapy; D002648:Child; D002845:Chromatography; D002850:Chromatography, Gel; D003169:Complement Inactivator Proteins; D003911:Dextrans; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D007116:Immunization, Passive; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G / Q000302:isolation & purification; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010920:Placenta / Q000276:immunology; D014461:Ultracentrifugation; D014777:Virus Diseases / Q000628:therapy; D005719:gamma-Globulins / Q000008:administration & dosage / Q000378:metabolism / Q000592:standards*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D003169:Complement Inactivator Proteins; D003911:Dextrans; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D005719:gamma-Globulins; D005341:Fibrinolysin