title: Effect of progesterone on collagen breakdown and tissue collagenolytic activity in the involuting rat uterus.
abstract: Progestational agents were studied for their effects on collagenolytic activity and loss of collagen and wet weight from the involuting post-partum rat uterus. Administration of very large doses of progesterone (80-150 mg/day) significantly retarded uterine involution and loss of collagen. This was accompanied by a significant reduction in uterine collagenolytic activity. By 72 h post partum, uteri of rats treated with 150 mg progesterone/day had wet weights 30% above, collagen 85% above, and collagenolytic activity 45% below, those of the control uteri. Similar effects were produced by 17alpha-acetoxy-6alpha-methylprogesterone at the same dosage levels. However, the progestational agent 6-chloro-17alpha-acetoxypregna-4,6-diene-3,20-dione acetate had no effect in this system.
mesh_terms: D000818:Animals; D002715:Chlormadinone Acetate / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006908:Hydroxyprogesterones / Q000031:analogs & derivatives* / Q000494:pharmacology; D049590:Postpartum Period; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
chemical_list: D006908:Hydroxyprogesterones; D002715:Chlormadinone Acetate; D011374:Progesterone; D003094:Collagen