Aspirin-caffeine interaction in the rat.
Both aspirin at a high dose (400 mg kg-1) and caffeine (5 mg kg-1) induced hyperactivity in the DA rat, but lower doses of aspirin were without effect. Caffeine-induced hyperactivity was brief (2 h) but that due to aspirin was evident from 1--6 h after dosing. Co-administration of the two drugs caused long-lasting hyperactivity, even with doses of aspirin which had no stimulant effects themselves. Absorptive and metabolic effects did not appear to play a major role in the interaction. The most likely effect is that of salicylate on catecholamine utilization in the central nervous system, which is compounded in the presence of a phosphodiesterase inhibitor.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002110:Caffeine / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012459:Salicylates / Q000097:blood
D012459:Salicylates; D002110:Caffeine; D001241:Aspirin