Histamine H1- and  H2- receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle.
Intra-arterial fusions of histamine cause vasodilation of resistance vessels, extravasation of albumin and oedema in cat skeletal muscle. Treatment with either mepyramine or metiamide significantly reduced the extravasation of albumin and rate of oedema formation. The doses of mepyramine and metiamide used did not modify the vascular responses to bradykinin.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002415:Cats; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D009132:Muscles / Q000098:blood supply; D011738:Pyrilamine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D012709:Serum Albumin; D008785:Metiamide; D006632:Histamine; D011738:Pyrilamine; D001920:Bradykinin