[Light- and electron-microscopic changes in liver cells of a patient with acute liver damage caused by Lindane].
Acute liver-lesion was observed in a 77 years old women, using a preparate "Hungaria L. 7" consisting 7,8 percent of Lindan, without keeping directions for use. In 24 hours onset of toxic exanthema, lack of appetite, and abdominal pains were seen. After a longlasting discomfort and loss of weight on the 4th week jaundice have occurred. In the liver biopsy specimen microscopically centrolobular necrosis of lytic type, steatosis and a moderate periportal inflammatory reaction was revealed. On the electron micrographs steatosis and paralelly arranged osmiophilic inclusions in the mitochondria seemed to the most characteristic feature. Authors stress that in cases of acute liver lesions careful analysis of the history may evidence a toxic origin of the lesion, and the latter morfologically--as it is demonstrated in the presented case--can be distinguished from the acute virus-hepatitis.
D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000139:chemically induced; D008930:Mitochondria, Liver / Q000648:ultrastructure
D001556:Hexachlorocyclohexane
Fény- és elektronmikroszkópos májsejt elváltozások Lindan hatásnak kitett egyén heveny májkárosodásában