title: Inhibition of the Fc receptor of human lymphoid cells by antisera-recognizing determinants of the hla system.
abstract: The inhibitory effect of HLA antisera on Fc receptors of human lymphoid cells was investigated. The ability of lymphoid cells to form rosettes (FcRFC) with antibody-coated sheep red blood cells and to function as effector cells (K cells) in antibody-dependent cell-mediated cytotoxicity were used as assay systems. We found that antisera recognizing determinants of the HLA-A, -B, and -C series had no effect on FcRFC, while a specific inhibitory effect was observed of antisera probably reacting with determinants identical to or closely associated with those of the HLA-D series. This inhibitory effect was retained in the F(ab')2 fragments. Specific inhibition of K cells was observed with all HLA antisera, but this effect was lost in the F(ab')2 fragments. We conclude that the Fc receptor of rosette-forming lymphocytes may be closely associated with products of the HLA-D region. This is analogous to the association between the Fc receptor and the Ia antigens on murine rosette-forming B lymphocytes.
mesh_terms: D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007104:Immune Adherence Reaction; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies; D008214:Lymphocytes / Q000276:immunology*; D011955:Receptors, Drug
chemical_list: D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies; D011955:Receptors, Drug