The treatment of threatened premature labor by betamimetic drugs: a comparison of fenoterol and ritodrine.
Studies have shown that, in patients with threatened premature labor, fenoterol and ritodrine are effective agents for delaying its onset. However, the side-effects of these drugs can be a problem. Among 133 patients studied, the intravenous administration of either agent caused marked tachycardia (but no changes in blood pressure) and a high incidence of palpitations, trembling, and nausea. During oral therapy, subjective symptoms were less frequent. The addition of the calcium antagonist, iproveratril, to the therapeutic regimen did not influence the effectiveness of the 2 agents or the incidence of their adverse side-effects.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005313:Fetal Death; D006339:Heart Rate; D006801:Humans; D007226:Infant Mortality; D009325:Nausea / Q000139:chemically induced; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies; D012312:Ritodrine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D014700:Verapamil; D012312:Ritodrine