title: Further studies on telestability in DNA. The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20).
abstract: The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20) are described. Thermal denaturation studies on these DNAs in the absence and presence of actinomycin, which binds only to the GC portions of these molecules, have confirmed and extended our previous observation that the properties of one region of a DNA can be influenced (telestabilized) by a remote region. In addition, the large scale synthesis of d(C15A15) - d(T15G15) is described.
mesh_terms: D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D003090:Coliphages / Q000201:enzymology; D004247:DNA / Q000096:biosynthesis; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004267:DNA Viruses / Q000201:enzymology; D003609:Dactinomycin / Q000494:pharmacology; D003851:Deoxyribonucleases; D003854:Deoxyribonucleotides; D004355:Drug Stability; D006358:Hot Temperature; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000096:biosynthesis; D010179:Pancreas / Q000201:enzymology; D011119:Polynucleotides / Q000096:biosynthesis; D013950:Thymus Gland / Q000201:enzymology
chemical_list: D003854:Deoxyribonucleotides; D009841:Oligonucleotides; D011119:Polynucleotides; D003609:Dactinomycin; D004247:DNA; D004254:DNA Nucleotidyltransferases; D003851:Deoxyribonucleases