A rabbit used as a model for testing hematopoietic tissue transplants.
Allogenic transplantations of bone marrow or spleen cells were carried out on rabbits treated with cyclophosphamide. About 50% of the recipients developed chimerism of peripheral blood cells. Chimerism was a passing phenomenon prevailing from 14 to 180 days after grafting. A phenomenon indicating that not all cell lines develop after transplantation from the donor stem cells, was observed. This phenomenon has been called "restricted chimerism". The GvH reaction was of a chronic type. Relative spleen weights were significantly increased in animals receiving the spleen cell grafts, but not in animals receiving bone marrow grafts. A direct positive erythrocyte Coombs test was found in almost all graft recipients. In addition cytotoxic autoantibodies against lymphocytes were present in sera of about 20% of the recipients.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001789:Blood Group Antigens; D016026:Bone Marrow Transplantation; D002678:Chimera; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011817:Rabbits / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D014184:Transplantation, Homologous
D000954:Antigens, Surface; D001323:Autoantibodies; D001789:Blood Group Antigens; D003520:Cyclophosphamide