[Alpha-fetoprotein in assessing obstetric diagnosis (author's transl)].
Radio-immunologic measurement of alpha-fetoprotein is possible in small amounts of blood and amniotic fluid. During the first half of pregnancy the AFP values in maternal serum are lowered when there is fetal abnormality (hydatid cyst, immnent abortion). In the second half of pregnancy high values of AFP also indicate danger to the fetus (Rh-incompatibility). The older the pregnancy the AFP values in amniotic fluid fall. In pathologic pregnancy (hydramnion, anencephaly, trisomy) AFP concentration was normal or raised. Measurement of the AFP level in umbilical cord -- blood provides further diagnostic chances: assessment of the duration of pregnancy and, therefore, of fetal maturity.
D000033:Abortion, Threatened / Q000097:blood; D000653:Amniotic Fluid / Q000032:analysis; D000757:Anencephaly / Q000097:blood; D004899:Erythroblastosis, Fetal / Q000097:blood; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood; D006831:Polyhydramnios / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D014314:Trisomy; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000097:blood
D005326:Fetal Proteins; D000509:alpha-Fetoproteins
Die Bedeutung des Alpha-Fetoproteins in der geburtshilflichen Zustandsdiagnostik