The effect of simultaneous administration of 3,4-dihydroxyphenylpyruvic acid and L-dopa on the bioavailability of L-dopa in rat and mouse.
In the rat, administration of 3-(3,4-dihydroxy)-L-phenylalanine (L-dopa) simultaneously with the corresponding alpha-keto acid, 3,4-dihydroxyphenylpyruvic acid (DHPPA), gives significantly higher concentrations of L-dopa in the serum and of dopamine and homovanillic acid in the brain than the same dose of L-dopa alone. Correspondingly, DHPPA potentiates the effect of L-dopa on the locomotor activity in reserpine-treated mice. DHPPA is postulated to increase the absorption of intact L-dopa from the gut by preventing the transamination reaction between L-dopa and the physiological alpha-keto acids.
D000818:Animals; D001682:Biological Availability; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000378:metabolism; D007980:Levodopa / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010667:Phenylpyruvic Acids / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology
D010667:Phenylpyruvic Acids; C019344:3,4-dihydroxyphenylpyruvic acid; D007980:Levodopa; D012110:Reserpine; D004298:Dopamine; D006719:Homovanillic Acid