title: [Use of various preparations with beta-adrenergic blocking action in the overall therapy of thyrotoxicosis].
abstract: Three beta-adrenoblockers (trasicor, alpheprol, isoptin) were used in 68 patients with thyrotoxicosis in the complex therapy of the disease. Their effect on hemodynamic indices, urinary catecholamine excretion were studied, and the results of investigation were compared with the data obtained earlier with the use of anaprylin. The action of the latter on the thyroid metabolism was ascertained. Anaprylin proved to be the most effective of the aforementioned preparations. Trasicor, which was somewhat less effective, could be used in patients with thyrotoxicosis complicated by cardiovascular insufficiency due to its less pronounced inotropic action. Isoptin may be recommended as an anti-arrhythmic agent in thyrotoxicosis. The action mechanism of beta-adrenoblockers in thyrotoxicosis is suggested.
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000526:Alprenolol / Q000627:therapeutic use; D002395:Catecholamines / Q000652:urine; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010096:Oxprenolol / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D013963:Thyroid Hormones; D010096:Oxprenolol; D000526:Alprenolol; D014700:Verapamil
vernacular_title: Primenenie razlichnykh preparatov beta-adrenoblokiruiushchego deĭstviia v kompleksnoĭ terapii tireotoksikoza.