title: [Correlations between chemical structure and cardiac effectivity of a group of beta-receptor blockaders].
abstract: 13 compounds from the families of halogenated phenylethanolamines and phenoxypropanol-amines were tested for their antagonistic effect against an isoproterenol-induced increase in heart rate and lowering of blood pressure, and the AD50 values were determined. All the substances had beta-adrenolytical effects. 2.4-Difluoroisoproterenol and 1-(2.4-dichlorophenoxy)-3-t-butylaminopropanol-(2) showed a higher affinity to the beta1-receptors of the heart than to the beta2-receptors of the vessels. Correlations existing between chemical structure and action on the adrenergic beta-receptors are described.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000319:Adrenergic beta-Antagonists; D007545:Isoproterenol
vernacular_title: Beziehungen zwischen chemischer Struktur und Herz-Kreislauf-Wirksamkeit einer Gruppe von beta-Rezeptorenblockern.