Effects of ketotifen and clemastine on passive transfer of reaginic reaction.
Passive transfer (PK) tests were performed with a reaginic serum on a recipient reacting with an immediate and a more prolonged reaction when specificity challenged. Both reactions are thought to be mediated by IgE immunology. Ketotifen, a cycloheptathiophene derivative, and clemastine, given to the recipient in maximal clinical doses for 3 days, inhibited the immediate reaction. Ketotifen had a very slight effect also on the prolonged reaction. The results indicate that the in vivo effects of ketotifen in the human system are due not so much to mast cell inhibitory mechanisms, but more to post-release antihistaminic and some anti-inflammatory properties.
D002974:Clemastine / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000276:immunology; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D010880:Piperidines / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000627:therapeutic use*; D011935:Reagins / Q000276:immunology; D013876:Thiophenes / Q000627:therapeutic use*; D013997:Time Factors
D006634:Histamine H1 Antagonists; D010880:Piperidines; D011759:Pyrrolidines; D011935:Reagins; D013876:Thiophenes; D007073:Immunoglobulin E; D002974:Clemastine