title: [Flunitrazepam with anterograde amnesia and reduction of blood pressure before local anaesthesia without intubation in 3000 ENT operations (author's transl)].
abstract: After premedication with flunitrazepam=Rohypnol 2 mg orally (2--3 hours preop.) and morphine-atropine (30 min preop.) the patient receives slowly "Ro" i.v. until the phenomenon of volume reduction when speaking is observed. This allows for the smallest possible dosis to achieve sufficient amnesia. After about 20 min the patient becomes responsive again, while his amnesia lasts for about 3 hours more. The cardiovascular functions remain stable with a 25% decrease of systolic blood pressure. Vomiting is reduced. The dry operative field makes microsurgery much easier and improves the final result of the operation. After gaining sufficient experience of the staff, 100% amnesia was achieved in all operations during the last 3 months.
mesh_terms: D000284:Administration, Oral; D000772:Anesthesia, Local; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001285:Atropine; D001794:Blood Pressure / Q000187:drug effects*; D005445:Flunitrazepam / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D009020:Morphine; D010038:Otorhinolaryngologic Diseases / Q000601:surgery*; D011229:Preanesthetic Medication; D012677:Sensation / Q000187:drug effects*
chemical_list: D014151:Anti-Anxiety Agents; D005445:Flunitrazepam; D009020:Morphine; D001285:Atropine
vernacular_title: Flunitrazepam mit anterograder Amnesie und Blutdrucksenkung vor der Lokalaästhesie ohne intubation bei 3000 HNO-Operationen.