Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor.
The biologically acitve entity termed allogeneic effect factor, which is produced by alloantigen-activated T cells and has been shown to regulate triggering and differentiation of B lymphocytes in vitro, has previously been demonstrated to possess antigenic determinants coded by genes in the I region of the H-2 gene complex of the mouse. The studies presented here provide evidence that allogeneic effect factor also possesses antigenic determinants identical or cross-reactive with beta2-microglobulin. These observations suggest an important role for beta2-microglobulin in the mechanism of cell-cell interactions and the consequences of such interactions on lymphocyte triggering and differentiation.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001609:Beta-Globulins / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D006649:Histocompatibility Antigens; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology*
D001609:Beta-Globulins; D000939:Epitopes; D006649:Histocompatibility Antigens; D001613:beta 2-Microglobulin