title: Deterioration of glucose tolerance in hypertensive patients on prolonged diuretic treatment.
abstract: Glucose tolerance was investigated in 51 hypertensive patients before and after 1 and 6 years of treatment with oral diuretics. Glucose tolerance was unchanged after 1 year but had deteriorated significantly after 6 years' therapy. In a comparable group of 16 patients tested at similar intervals in which diuretic therapy had been given only for 3 of the 6 years there was no change in glucose tolerance, suggesting that prolonged oral treatment with thiazide diuretics is diabetogenic.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001581:Benzothiadiazines; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D003920:Diabetes Mellitus / Q000139:chemically induced; D004232:Diuretics; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D001581:Benzothiadiazines; D001786:Blood Glucose; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D014508:Urea; D011188:Potassium