title: Two mechanisms for hypothyroidism after 131I therapy.
abstract: It is proposed that the incidence of hypothyroidism after radioiodine therapy of thyrotoxicosis has two distinct mechanism. One operates in the first two years after therapy and depends on radiation dose. The other operates in later years, and is not, to any significant extent, dose dependent. Possible canidates for each mechanism are explored.
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D006980:Hyperthyroidism / Q000532:radiotherapy*; D007037:Hypothyroidism / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D011830:Radiation Effects; D011879:Radiotherapy Dosage; D013961:Thyroid Gland / Q000166:cytology / Q000528:radiation effects*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes