title: Critical evaluation of hypertonic and hypotonic solutions to resuscitate severely burned children: a prospective study.
abstract: Children with thermal burns covering 30% or more of the body surface area were alternately resuscitated with either hypertonic lactated saline (HLS) or lactated Ringer's solution (LRS). Parameters sequentially measured and calculated included: 1) serum and urine electrolyte concentrations, 2) serum and urine osmolalities, 3) arterial blood gases, 4) total and fractional serum proteins, 5) blood urea nitrogen, complete blood count and blood sugar concentration, 6) changes in body weight, 7) sodium, potassium and water balance. The water load received by the HLS group was significantly less through 48 hours postburn (49% at 8 hours, 44% at 24 hours and 38% at 48 hours postburn). Although the HLS group received significantly more sodium than the LRS group, there was no difference in sodium balance at 48 hours postburn. This is explained by the fact that the HLS group, at 48 hours postburn, retained significantly less of the administered sodium load (69% vs. 83%). Positive water balance was significantly greater in the LR group for the first 48 hours postburn. This study suggests that current hypotonic fluid regimens for burn resuscitation contain water in excess of that required for proper resuscitation. Severely burned children may be safely and efficiently resuscitated with conventional salt loads and one-third less than usual water loads.
mesh_terms: D001769:Blood; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D002056:Burns / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007038:Hypotonic Solutions / Q000627:therapeutic use*; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood; D011188:Potassium / Q000097:blood; D011446:Prospective Studies; D012151:Resuscitation / Q000379:methods*; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance
chemical_list: D001798:Blood Proteins; D007038:Hypotonic Solutions; D012462:Saline Solution, Hypertonic; D002245:Carbon Dioxide; D012965:Sodium Chloride; D012964:Sodium; D011188:Potassium; D010100:Oxygen