title: Studies on the antigenic structure of tetanus toxin.
abstract: The isolation and purification of split-products from tetanus toxin after freezing is reported. Antigenically defective and non-defective fragments exhibiting reduced molecular weights with respect to that of intact toxin were investigated as to their biological and immunological properties. The results obtained are discussed in relation to other data from the literature.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial / Q000032:analysis*; D002850:Chromatography, Gel; D004356:Drug Storage; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D005428:Flocculation Tests; D005615:Freezing; D007106:Immune Sera / Q000302:isolation & purification; D005779:Immunodiffusion; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D011233:Precipitin Tests; D011817:Rabbits; D013744:Tetanus Toxin / Q000032:analysis / Q000302:isolation & purification / Q000633:toxicity; D014121:Toxoids / Q000302:isolation & purification
chemical_list: D000942:Antigens, Bacterial; D000939:Epitopes; D007106:Immune Sera; D013744:Tetanus Toxin; D014121:Toxoids