Cocaine as a discriminative cue in rats: interactions with neuroleptics and other drugs.
Rats were trained to discriminate between the effects of 4 mg/kg of cocaine HCl and saline (1 ml/kg) in a T-shaped maze. When the animals reliably differentiated the imposed training conditions (cocaine vs. no drug), test sessions were interspersed in between the regular training sessions. Test trials resulted in a median effective dose (ED50) of 1.6 mg/kg of cocaine, and the duration of the discriminable effects of cocaine in producing 50% cocaine-appropriate responding was 57.9 min postinjection. Pretreatment with neuroleptics (pimozide, haloperidol, and chlorpromazine), but not with propranolol, phenoxybenzamine, alpha-methyl-para-tyrosine, or physostigmine, attenuated the cocaine discrimination. Data are discussed with reference to previous results from amphetamine discriminations.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D003463:Cues; D004192:Discrimination, Psychological / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D014150:Antipsychotic Agents; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D011433:Propranolol; D003042:Cocaine