d-Amphetamine binding to brain lipid.
The interaction of d-amphetamine with several brain tissue components has been investigated. A brain lipid extract and a number of individual phospholipids were found to bind d-amphetamine when measured by means of a hexane-buffer partition coefficient technique. Phosphatidylserine showed the greatest binding and phosphatidylethanolamine and dipalmitoyllecithin were also effective. Phospholipid binding of d-amphetamine was shown to be related to fatty acid composition. Cholesterol and ganglioside did not bind. It is suggested that phospholipid binding of d-amphetamine may play a role in the pharmacological action of this drug.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D003913:Dextroamphetamine / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008563:Membrane Lipids / Q000378:metabolism*; D008956:Models, Chemical; D010743:Phospholipids / Q000378:metabolism; D012995:Solubility; D013329:Structure-Activity Relationship
D008563:Membrane Lipids; D010743:Phospholipids; D003913:Dextroamphetamine