Effects of cytosine arabinoside on the incorporation of pyrimidine nucleosides into hamster cells transformed by herpes simplex type 1 and type 2 viruses and by human cytomegalovirus.
The incorporation of 3H-thymidine and 3H-deoxycytidine into acidoprecipitable fraction of hamster cells transformed by herpes simplex viruses type 1 and type 2 and of 3H-thymidine into hamster cells transformed by human cytomegalovirus was found to be resistant to the action of cytosine arabinoside. More 3H-thymidine was incorporated into these cells in the presence than in the absence of the drug. Similar stimulaton of 3H-thymidine uptake could be achieved by using unlabelled deoxycytidine instead of cytosine arabinoside. Incorporation of both nucleosides into spontaneously and SV40 transformed cells was efficiently inhibited by the drug.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D006224:Cricetinae; D003561:Cytarabine / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000502:physiology*; D003841:Deoxycytidine / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D010766:Phosphorylation; D011741:Pyrimidine Nucleosides / Q000378:metabolism*; D018139:Simplexvirus / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism
D011741:Pyrimidine Nucleosides; D003561:Cytarabine; D003841:Deoxycytidine; D013936:Thymidine