Artifacts produced by using dichloromethane in the extraction and storage of some antihistaminic drugs.
The use of dichloromethane for the extraction of amines may lead to the formation of artifacts. Dichloromethane reacts rapidly (37.5 degrees) with brompheniramine, diphenylpyraline, cyclizine, cyproheptadine but not with antazoline and lignocaine. This difference in reactivity as well as the thin-layer chromatographic, gas-liquid chromatographic, nuclear magnetic resonance, and mass spectrometric characteristics of cyclizine and diphenylpyraline chloromethochlorides are investigated.
D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006634:Histamine H1 Antagonists / Q000302:isolation & purification*; D006843:Hydrocarbons, Chlorinated; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008752:Methylene Chloride
D006634:Histamine H1 Antagonists; D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride