99mtc-unithiol complex, a new radiopharmaceutical for kidney scintigraphy III. Studies of labelling unithiol with 99mtc.
Labelling of 2, 3-dimercaptopropane sodiumsulphonate (Unithiol) with 99mTc resulted in essentially three components in the GCS pofile: the top zone, a low-molecular Complex A and a high-molecular Complex B. In the presence of tin metal a fourth component, Complex C, could be distinguished. Complex A was relatively independent of pH, the proportion of Complex B increased with increasing pH. Methods were developed for preparing, with over 80% labelling efficiency, either Complex A or Complex B, each having high stability in the preparation vials and in human blood.
D002712:Chlorides; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007553:Isotope Labeling; D007668:Kidney / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013667:Technetium; D014001:Tin / Q000032:analysis; D014494:Unithiol / Q000032:analysis
D002712:Chlorides; D004338:Drug Combinations; D004112:Dimercaprol; D014494:Unithiol; D013667:Technetium; D014001:Tin