title: Rapid axonal transport in trigeminal nerve of rat.
abstract: The rat trigeminal nerve was investigated as a model system for axonal transport to identifiable sensory nerve endings. Following stereotaxic injection of [3-H]proline into the ganglion, the distribution of label in protein and other extracts of ligated or unligated infraorbital nerve was measured in replicates at various time intervals from 30 min to 3 days. In unligated nerves the average maximum velocity of somatofugal protein transport was 228 mm/day. Light microscope autoradiography demonstrated rapid intraaxonal transport of radioactive material to nerve endings in molar teeth and vibrissae. The system appears suitable for investigating the fate of axonally transported material at peripheral receptors.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism*; D011232:Chemical Precipitation; D008026:Ligation; D008297:Male; D009411:Nerve Endings / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D011392:Proline / Q000378:metabolism; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D013238:Stereotaxic Techniques; D013997:Time Factors; D014238:Trichloroacetic Acid / Q000494:pharmacology; D014276:Trigeminal Nerve / Q000378:metabolism*; D014316:Tritium
chemical_list: D009419:Nerve Tissue Proteins; D014316:Tritium; D011691:Puromycin; D014238:Trichloroacetic Acid; D011392:Proline