title: The effects of a hydroxyl group on some chemical and biological properties of n-pentyl ammonium salts.
abstract: The effects of a hydroxyl group on the activity and affinity of compounds related to n-pentyltrimethylammonoum have been studied on the guinea-pig ileum, frog rectus, acetylcholinesterase and on partitioning (Rm) and size (phiov, Vm). The hydroxyl group lowered affinity in all tests, confirming the importance of hydrophobic forces in binding to receptors. Activity on the ileum was lowered appreciably but on the rectus only slightly. The effects on Rm did not indicate any interactions between hydroxyl, onium group and water but the apparent size of the hydroxyl group (deltaphiov) depends on the nature of the onium group.
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001001:Anura; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002800:Cholinesterase Inhibitors; D002854:Chromatography, Paper; D004593:Electrophorus; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000032:analysis / Q000494:pharmacology*; D011896:Rana temporaria; D011950:Receptors, Cholinergic / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D000109:Acetylcholine