[Interferon induced in the hamster by subunits of "Nocardia": essay of protection against rabies (author's transl)].
Lipid-free cells of Nocardia opaca and a cell extract (NWSM) are interferon inducers in syrian hamsters: peak interferon appears 2 h after injection as compared to 8 h in the case of interferon induced by inactivated NDV virus. The interferon induced by Nocardia product is inactivated by a treatment for 30 min at 56 degrees C or 24 h at pH 2: NDV-induced interferon is more stable under these conditions. Hamsters inoculated with NWSM before and after infection with rabies virus are partially protected: their survival time is slightly increased.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D006224:Cricetinae; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007369:Interferon Inducers; D007372:Interferons / Q000032:analysis; D008647:Mesocricetus; D051379:Mice; D009522:Newcastle disease virus / Q000276:immunology; D009615:Nocardia / Q000276:immunology*; D011818:Rabies / Q000517:prevention & control*
D007369:Interferon Inducers; D007372:Interferons
Induction de la synthèse d'interféron chez la hamster par des fractions de Nocardia: essais de protection contre la rage par le NWSM.