Mononuclear cells in human synovial fluid. Identification of lymphoblasts in rheumatoid arthritis.
A simple method was developed to identify large mononuclear (LMN) cells in human synovial fluid based on morphology and staining with Sudan black B. All cells were classified as monocyte-derived macrophages (MDM), lymphoblasts (LB), or synovial lining cells (SLC). Lymphoblasts were seen in 58 of 60 rheumatoid fluids (mean: 69 +/- 18% LB per LMN cells). However lymphoblasts were rarely seen in synovial fluids from patients with crystal-induced synovitis or bacterial infections.
D001172:Arthritis, Rheumatoid / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D013194:Staining and Labeling; D013582:Synovial Fluid / Q000166:cytology*; D013583:Synovial Membrane / Q000473:pathology