title: WRL 105 strain (H3N2) live attenuated influenza vaccine: acceptability, reactivity, and antibody response in normal, bronchitic, and geriatric volunteers.
abstract: The acceptability, reactivity, and antibody responses of recombinant WRL 105 strain, live, attenuated influenza virus vaccine administered intranasally were studied in seventeen normal adults, and in seventeen bronchitic and twenty-one geriatric volunteers. The effect on peak flow and 1-second forced expiratory volume (F.E.V.1) on the 3rd, 5th, and 7th days after vaccination was measured in the bronchitic and normal groups. Seroconversion occurred in 80% to tht homologous virus, in 40.6% to A/Victoria/3/75, and in 26.5% to A/England/864/75 in subjects with pre-vaccination haemagglutination inhibition titres of less than 1/40. A fourfold or greater increase in homologous anti-neuraminidase antibody was found in 48% of twenty-seven infected subjects when measured by a new elution inhibition technique. The frequency and nature of symptoms were similar in both infected and non-infected groups. No significant changes in F.E.V.1 occurred, but on days 5 and 7 there was a decrease in peak flow measurements in both infected and non-infected groups when assessed as the percentage change of the pre-vaccination value.
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000302:isolation & purification*; D000917:Antibody Formation; D001991:Bronchitis / Q000276:immunology* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D005260:Female; D005541:Forced Expiratory Volume; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000032:analysis; D009975:Orthomyxoviridae / Q000276:immunology*; D010366:Peak Expiratory Flow Rate; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D009439:Neuraminidase