Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase.
The synthesis and characterization of the addition product of NADP and decanaldehyde are described. This adduct is an inhibitor of beef brain NADP-linked aldehyde reductase (Ki = 2.3 x 10(-6) M) along with the NADP adducts of butyraldehyde, phenylpropionaldehyde, and phenylacetaldehyde.
D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors*; D000447:Aldehydes / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002417:Cattle; D066298:In Vitro Techniques; D007700:Kinetics; D009249:NADP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000447:Aldehydes; C021170:decanaldehyde; D009249:NADP; D000445:Aldehyde Oxidoreductases