Ultrastructural localization of in vivo bound immunoglobulins in bullous pemphigoid--a preliminary report.
The ultrastructural location of in vivo bound immunoglobulins in a case of bullous pemphigoid was determined by coupling peroxidase to antihuman gamma globulin. Immunoglobulin deposits were found exclusively in the space between the basal cells and the basal lamina. The location of the immunoglobulin in bullous pemphigoid thus differs from that in lupus erythematosus where immunoglobulins are found mainly below the basal lamina.
D000888:Antibodies, Anti-Idiotypic; D002462:Cell Membrane / Q000276:immunology / Q000648:ultrastructure; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010544:Peroxidases; D010944:Plants / Q000201:enzymology; D012867:Skin / Q000276:immunology / Q000648:ultrastructure; D012871:Skin Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005719:gamma-Globulins
D000888:Antibodies, Anti-Idiotypic; D007136:Immunoglobulins; D005719:gamma-Globulins; D010544:Peroxidases