Renal function in hypercalcemic dogs during hydropenia and during saline infusion.
The effects of calcium-gluconate infusions on renal function were studied in unanesthetised dogs. Each dog was studied during hydropenia and saline infusion. Hypercalcemia, mean serum calcium 3.85 mmol/l (hydropenia) and 3.62 mmol/l (saline infusion), increased fractional excretion of sodium (CNa/CIn), calcium (CCa/CIn), and magnesium (CMg/CIn). The increase was significantly higher in saline-expanded dogs than in hydropenic dogs. Fractional excretion of potassium (CK/CIn) was increased in hydropenia but remained unchanged in saline-expanded animals. Fractional excretion of phosphate (Cp/CIn) was not consistently changed by hypercalcemia. Fractional excretion of chloride (CCl/CIn) was markedly increased in saline-expanded dogs but was not changed in hydropenia. Urine osmolality was reduced in hydropenic dogs but unchanged in saline-expanded dogs. In hydropenic as well as in saline-expanded dogs tubular reabsorption of solute-free water (TcH2O/CIn) increased during the first hour of hypercalcemia. In hydropenic dogs hypercalcemia caused a slight but significant decrease in blood pH, standard bicarbonate, and base excess. In hydropenic as well as in saline-expanded dogs glomerular filtration rate (CIn), renal plasma flow (CPAH), and filtration fraction were unaffected.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001834:Body Water / Q000378:metabolism*; D002125:Calcium Gluconate / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D006934:Hypercalcemia / Q000503:physiopathology*; D007263:Infusions, Parenteral; D007668:Kidney / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D009994:Osmolar Concentration; D010101:Oxygen Consumption; D010313:Partial Pressure; D012039:Regional Blood Flow / Q000187:drug effects; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D001639:Bicarbonates; D012965:Sodium Chloride; D002125:Calcium Gluconate