The preparation of the factors IX, II, and X concentrate by means of DEAE cellulos and its therapeutic effectiveness.
Starting from a plasma used for producing cryoprecipitate a concentrate was gained by means of adsorption on DEAE cellulose, the factor IX activity of which was six to thirteen times higher than that of the original plasma. Even the factors X and II are enriched to the same extent approximately. In patients with haemophilia B the concentrate proved to be very efficient and compatible during surgical operations.
D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002848:Chromatography, DEAE-Cellulose / Q000379:methods; D005164:Factor IX / Q000302:isolation & purification*; D005170:Factor X / Q000302:isolation & purification*; D002836:Hemophilia B / Q000628:therapy; D006801:Humans; D008722:Methods; D011516:Prothrombin / Q000302:isolation & purification*; D013917:Thrombin / Q000032:analysis; D013925:Thromboplastin / Q000032:analysis
D001779:Blood Coagulation Factors; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D013925:Thromboplastin; D013917:Thrombin