Effects of terbutaline, a synthetic beta adrenoceptor agonist, on in vivo erythropoietin production.
Terbutaline sulfate, a new synthetic beta2-adrenoceptor agonist, was found to produce a dose-related increase in 59Fe-incorporation into newly formed red blood cells of exhypoxic polycythemic mice. This effect was blocked by prior treatment of the polycythemic mice with the potent beta-adrenoceptor antagonist, DL-propranolol. Terbutaline was also infused (i.v.) (500 microgram/kg/min) into restrained unanesthetized rabbits for a period of 5 hr with constant monitoring of arterial blood pressure and periodic blood Po2, Pco2, and pH analyses. Terbutaline was found to significantly elevate plasma erythropoietin titers in rabbits while producing a slight but nonsignificant decrease in mean blood pressure. Terbutaline did not produce a significant effect upon blood gases or blood pH. These data suggest a possible involvement of beta2-adrenoceptor activation of erythropoietin production.
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000096:biosynthesis*; D005260:Female; D006863:Hydrogen-Ion Concentration; D051379:Mice; D011086:Polycythemia / Q000503:physiopathology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D013726:Terbutaline / Q000494:pharmacology*; D013997:Time Factors
D004921:Erythropoietin; D011433:Propranolol; D013726:Terbutaline; D004837:Epinephrine