Surgery of congenital heart disease assessed by radionuclide scintigraphy.
Intravenous injection of 99mTc-labeled macroaggregated albumin (MAA) followed by lung and whole-body scintigraphy results in data from which magnitude of right-to-left shunting and distribution of pulmonary arterial blood flow can be calculated. This information is useful in assessing the functional capacity of a surgical systemic-pulmonic anastomosis. Malfunctioning anastomoses do not significantly reduce right-to-left shunting and may cause unilateral pulmonary hyperperfusion. However, preferential nuclide accumulation may occur in either lung, regardless of shunt function. Consequently, the degree of right-to-left shunting must be determined to fully assess a surgical anastomosis. This technique also allows for assessment of the reduction of right-to-left shunting after intracardiac repairs of congenital cardiac abnormalities.
D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010166:Palliative Care; D011652:Pulmonary Circulation; D011877:Radionuclide Imaging; D012709:Serum Albumin; D013667:Technetium; D013771:Tetralogy of Fallot / Q000503:physiopathology / Q000601:surgery
D012709:Serum Albumin; D013667:Technetium