title: Effect of ergocristine on prolactin secretion in the male rat with pituitaries grafted beneath the kidney capsule.
abstract: Male rats in which three pituitaries were grafted beneath the kidney capsule showed approximately a fourfold increase in circulating plasma prolactin concentration. The elevated plasma prolactin concentration did not remain at a constant level but fluctuated with time. The elevated prolactin concentration declined immediately after a single bolus injection of ergocristine (30 micrograms/kg). The slope of the prolactin decay curve, determined by sequential blood sampling, was parallel to a theoretical slope having a 7-min half-life. This result indicates that ergocristine blocked prolactin secretion immediately and completely as the decay curve (T 1/2 = 6.5 min, confidence interval 4.5--11.3) resulting from the administration of ergocristine is the same as the endogenous prolactin decay curve (T 1/2 = 7 min).
mesh_terms: D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D007016:Hypophysectomy; D007031:Hypothalamus / Q000502:physiology*; D007668:Kidney; D008297:Male; D010902:Pituitary Gland / Q000502:physiology* / Q000637:transplantation; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011389:Prolactin Release-Inhibiting Factors / Q000502:physiology; D051381:Rats; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D004873:Ergolines; D011388:Prolactin; D011389:Prolactin Release-Inhibiting Factors