title: Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus.
abstract: Recombination between Esterase-4 and Esterase-2 in the rat was not observed in 278 backcross offspring. Es-4 is thus included within the "esterase cluster" in Linkage group V. A new map of this region was constructed and the relationship of the four esterase loci was found to be: Es-4-(9.6+/-1.6 cM)-Es-2, Es-4-(1.5+/-0.7cM)-Es-3. Homology of this region with a region of Linkage Group XVIII (Chromosome 8) of the mouse was proposed on the basis of tissue distribution, subcellular localization and response of enzymes to inhibiotrs. Specifically, rat Es-1 was suggested as the homolog of mouse Es-6. An autosomal segment comprising at least 15cM of the rat and mouse genomes appears to have remained relatively intact with respect to genetic content during rodent speciation. In addition, a new polymorphism for mouse esterase was described. The locus was designated Esterase-10 (Es-10) and proposed as the mouse homolog of human Esterase D. Linkage of Es-10 with nucleoside phosphorylase-1-(Np-1) on Chromosome 14 was established.
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure; D004586:Electrophoresis; D004950:Esterases / Q000096:biosynthesis*; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D051379:Mice; D011110:Polymorphism, Genetic; D051381:Rats; D011995:Recombination, Genetic; D013045:Species Specificity; D013194:Staining and Labeling
chemical_list: D004950:Esterases