Kainic acid injections result in degeneration of cochlear nucleus cells innervated by the auditory nerve.
When kainic acid, a putative neurotoxin for neurons with glutamatergic input, is injected into the brainstem, it produces a selective pattern of degeneration in the cochlear nucleus. The rate and extent of degeneration is correlated with the distribution of the primary auditory fibers. This evidence supports the hypothesis that glutamate is the neurotransmitter for primary auditory fibers.
D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000502:physiology; D006168:Guinea Pigs; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000502:physiology; D011759:Pyrrolidines / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D000159:Vestibulocochlear Nerve / Q000187:drug effects* / Q000502:physiology
D005971:Glutamates; D018377:Neurotransmitter Agents; D011759:Pyrrolidines; D017981:Receptors, Neurotransmitter; D007608:Kainic Acid