The regulation of adenylate cyclase of the adrenal cortex.
This short review summarizes some of the data concerning the regulation of adrenocortical adenylate cyclase by ACTH and other putative effectors, such as guanosine and nucleotides, divalent cations and adenosine. The available information on ACTH-sensitive adenylate cyclase of the adrenal cortex is discussed in comparison to other cyclase systems and the possible biochemical mechanisms of action of ACTH on the adrenal cortex.
D000241:Adenosine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000302:Adrenal Cortex / Q000201:enzymology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D000242:Cyclic AMP / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000378:metabolism; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D007455:Iodine / Q000378:metabolism; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D011485:Protein Binding; D014443:Tyrosine / Q000378:metabolism
D010446:Peptide Fragments; D006165:Guanylyl Imidodiphosphate; D014443:Tyrosine; D006160:Guanosine Triphosphate; D000324:Adrenocorticotropic Hormone; D007455:Iodine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D008274:Magnesium; D000241:Adenosine; D002118:Calcium