Effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migration.
Possible modes of action of the anti-inflammatory drug, benoxaprofen, have been explored. The drug caused inhibition of leucocyte migration, principally of mononuclear cells into the pleural cavity of rats undergoing carrageenan-induced pleurisy. Evidence was obtained from in vitro leucocyte migration and chemotaxis models that the drug acted directly on the mononuclear cells rather than by inhibition of chemotactic factors.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001583:Benzoxazoles / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006168:Guinea Pigs; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D010998:Pleurisy / Q000503:physiopathology; D011422:Propionates; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; C011677:benoxaprofen