Comparison of antibody responses and reactivity of "Alice" and WRL 105 strain live influenza vaccines.
Groups of 45 adult volunteers were vaccinated intranasally with a single dose of either "Alice" or WRL 105 strain live influenza vaccines. Seroconversion rates against A/Scotland/840/74 were significantly greater following administration of WRL 105 but seroconversion rates against A/England/42/72, A/Port Chalmers/1/73, A/Finland/4/74, A/Victoria/3/75, and A/England/864/75 did not differ significantly between the two vaccines. Poor antibody responses were elicited by both "Alice" and WRL 105 strains against A/Victoria/3/75 and A/England/864/75. No severe reactions followed the administration of either vaccine.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000910:Antibodies, Heterophile / Q000302:isolation & purification; D000914:Antibodies, Viral / Q000302:isolation & purification*; D000937:Antigen-Antibody Reactions; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007110:Immunity, Active; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007252:Influenza Vaccines / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination
D000910:Antibodies, Heterophile; D000914:Antibodies, Viral; D007252:Influenza Vaccines