Effect of anti-alpha1-fetoprotein on alpha1-fetoprotein-producing rat tumors in vivo and in vitro.
Active or passive immunization of rats to alpha1-fetoprotein (AFP) does not consistently inhibit the growth of AFP-producing transplantable hepatomas in vivo, and anti-AFP does not kill these hepatomas in vitro. However, 3 of 14 rats in 1 experiment responded to passive immunization by reversal of tumor growth as evidenced by normalization of elevated AFP serum concentrations, and 1 of 9 rats actively immunized with rat AFP in complete Freund's adjuvant had suppressed growth of transplantable hepatoma 7777.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D005326:Fetal Proteins / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D066298:In Vitro Techniques; D008113:Liver Neoplasms; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D012882:Skin Tests; D000509:alpha-Fetoproteins / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D005326:Fetal Proteins; D000509:alpha-Fetoproteins