High dose desipramine, plasma drug levels and clinical response.
The concentration of tricyclic antidepressants in plasma may be a more important factor than the oral dose in determining whether or not a patient will respond to treatment. Knowledge of the drug dose-response curve and its levels in blood may enable the physician to convert a patient from a "nonresponder" into a "responder."
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002779:Cholestasis / Q000139:chemically induced; D003863:Depression / Q000188:drug therapy* / Q000201:enzymology; D003891:Desipramine / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012008:Recurrence; D005723:gamma-Glutamyltransferase / Q000097:blood
D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D003891:Desipramine