A new actinomycin complex produced by a Micromonospora species: fermentation, isolation, and characterization.
A species of Micromonospora, Micromonospora floridensis NRRL 8020, has been found to produce an actinomycin complex consisting of at least 25 active components. After solvent extraction of the complex, separation of the individual components was carried out by preparative thin-layer chromatography. Hydrolysis and subsequent electrophoretic and chromatographic identification of the amino acid content of each of the isolated components have shown differences from known actinomycins, and the probability exists that these contain a number of amino or imino acids not previously found in other members of this group of antibiotics.
D000596:Amino Acids / Q000032:analysis; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003609:Dactinomycin / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D005285:Fermentation; D008847:Micromonospora / Q000032:analysis / Q000378:metabolism*
D000596:Amino Acids; D003609:Dactinomycin