The effect of the photodecomposition of chlorpromazine on lecithin monolayers.
Chlorpromazine hydrochloride (cpz) is decomposed when irradiated with ultraviolet light, forming H+, hydrochloric acid, chlorpromazine sulphoxide and 2-hydroxypromazine. The order of the reaction (as measured by the expansion that is produced in a lecithin/cpz monolayer) varies between zero and about 3/4. The results have been used to explain some of the adverse side effects that are observed when patients are treated with cpz.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002746:Chlorpromazine / Q000032:analysis / Q000494:pharmacology / Q000528:radiation effects*; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010777:Photochemistry; D014466:Ultraviolet Rays
D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D002746:Chlorpromazine