Changes in lung lysyl oxidase activity in streptozotocin-diabetes and in starvation.
The effects of streptozotocin-induced diabetes and of starvation on the lysyl oxidase activity of rat lung were investigated. Enzyme activity was elevated 2--3 fold in the lungs of streptozotocin-diabetic rats. In contrast, starvation of rats produced a rapid loss of lung lysyl oxidase activity, with levels approximating 25% of control values after 48--72 h of starvation. Enzyme activity was essentially fully restored to control values upon refeeding the 48-h starved animals for 3 h. These studies demonstrate the responsiveness of lysyl oxidase to these physiological states and suggest a component, enzymatic basis of change in lung function known to occur in the diabetic state.
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D004549:Elastin / Q000096:biosynthesis; D008168:Lung / Q000201:enzymology*; D008297:Male; D008249:Protein-Lysine 6-Oxidase / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D013217:Starvation / Q000201:enzymology*
D003094:Collagen; D004549:Elastin; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase