title: Subepithelial collagen in intestinal malabsorption.
abstract: Intestinal biopsies from 146 patients with adult coeliac disease and 13 patients with intestinal villous atrophy of different aetiology were assessed for the presence of subepithelial collagen and compared with a group of 20 control subjects. Subepithelial collagen was a common and non-specific finding observed in intestinal biopsies from patients suffering from adult coeliac disease (36%) and tropical sprue. In adult coeliac disease the described subepithelial changes usually regress following treatment, though marked subepithelial collagen deposition may indicate a poor prognosis. The study showed that the presence of marked subepithelial collagen in a flat jejunal biopsy does not define a separate clinical entity.
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000473:pathology; D001284:Atrophy / Q000473:pathology; D001485:Basement Membrane / Q000032:analysis; D001706:Biopsy; D002446:Celiac Disease / Q000178:diet therapy / Q000473:pathology*; D003094:Collagen / Q000032:analysis*; D004847:Epithelial Cells; D004848:Epithelium / Q000032:analysis / Q000473:pathology; D005983:Glutens; D006801:Humans; D007410:Intestinal Diseases / Q000473:pathology; D007583:Jejunum / Q000032:analysis / Q000473:pathology*; D008286:Malabsorption Syndromes / Q000473:pathology*; D013322:Strongyloidiasis / Q000473:pathology; D008061:Whipple Disease / Q000473:pathology
chemical_list: D005983:Glutens; D003094:Collagen