title: [Current problems in therapy of evolutive malignant granuloma. Our experience with a new scheme of polychemotherapy].
abstract: Treatment of advanced Hodgkin's disease by associating vincristine, adriblastine, prednisone and procarbazine is compared with other widely employed protocols. Most subjects in the series had already received one or more drugs and had relapsed. In spite of this, 60% were still in complete remission one year after the administration of 6 courses of the new association. An account is given of maintenance therapy in Hodgkin's disease once remission is obtained, and the problems thus raised are illustrated.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008466:Mechlorethamine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Problemi attuali di terapia del granuloma maligno evoluto. La nostra esperienza su un nuovo schema di polichemioterapia