[Disodiumcromoglycate and histamine liberation by cotton dust extract in the rat (author's transl)].
1. Disodiumcromoglycate (DSCG) had no influence on the microscopical appearance of rat peritoneal mast cells either by i.p. injection (2 times 10(-5) g/ml) or by i.v. infection (10 mg/kg) nor by local application (2 times 10(-5)/1 times 10(-4) g/ml). 2. A particular effect of DSCG (2 times 10(-6)/2 times 10(-5) on the tonus of guinea pig ileum or an interaction with contractor activity due to histamine (3 times 10(-8)/1 times 10(-7) g/ml) has not been established. 3. Histamine liberation from rat peritoneal mast cells by i.p. injection of aqueous cotton dust extract was not inhibited by DSCG (2 times 10(-8)/2 times 10(-7) g/ml), histamine liberation was rather increased.
D000287:Administration, Topical; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000494:pharmacology*; D004391:Dust; D005260:Female; D003368:Gossypium; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D004391:Dust; D004205:Cromolyn Sodium
Dinatriumcromoglycat und Histaminfreisetzung bei der Ratte durch Extrakte von Baumvollstaub