Leucocyte migration inhibition in myasthenia gravis. The effect of thymectomy.
Cellular hypersensitivity in myasthenia gravis (MG) to the thymus, muscles and peripheral nerves was examined by the method of the leucocyte migration inhibition test. The group of MG patients without thymoma had inhibition of leucocyte migration by thymus antigens. After thymectomy, they had a normal value of leucocyte migration. However, in the group of MG patients with thymoma, the inhibition of leucocyte migration by thymus antigens was observed after thymectomy. No significant inhibition of leucocyte migration was observed using muscle and peripheral nerve antigens. Cellular immunity in myasthenia gravis and the pathogenesis of the disease was discussed.
D000328:Adult; D001327:Autoimmune Diseases; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology* / Q000601:surgery; D012584:Sciatic Nerve / Q000276:immunology; D013934:Thymectomy; D013945:Thymoma / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology