title: Preservation of platelet viability and function during storage of concentrates.
abstract: It has now been substantiated that the viability and function of concentrated platelets stored for 72 hours are best preserved at a storage temperature of 22 degrees C rather than 4 degrees C. However, in order to preserve viability at 22 degrees C several other conditions must be met and maintained, namely, an appropriate storage bag (Fenwal's PL-146, McGaw or Cutter's CL-2383), constant gentle agitation with a platform shaker, CPD anticoagulation, and a platelet concentration of less than 1.6 x 10(12)/liter. Unfortunately, in vitro parameters which can accurately assess stored platelet viability and function are not reliable.
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000925:Anticoagulants / Q000494:pharmacology; D001692:Biological Transport; D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation; D001810:Blood Volume; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival; D002951:Citrates / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000378:metabolism; D010974:Platelet Aggregation; D011143:Polyvinyl Chloride; D012701:Serotonin / Q000378:metabolism; D013696:Temperature
chemical_list: D000925:Anticoagulants; D002951:Citrates; D007773:Lactates; D012701:Serotonin; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D011143:Polyvinyl Chloride; D004492:Edetic Acid; D005947:Glucose