Induction of allergic encephalomyelitis using hydrosoluble adjuvant and the tryptophan region of myelin basic protein.
Experimental allergic encephalomyelitis has been induced in guinea pigs using the encephalitogenic tryptophan peptide as antigen and a hydrosoluble adjuvant extracted from Mycobacterium tuberculosis, var. hominis, strain H37Ra. The maximum response was observed using 100mug of adjuvant per animal. This is a quantity of adjuvant substantially higher than was necessary to induce disease utilizing the whole myelin basic protein as antigen.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced*; D005260:Female; D006168:Guinea Pigs; D007271:Injections, Intradermal; D009169:Mycobacterium tuberculosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000494:pharmacology*; D010452:Peptide Biosynthesis; D010455:Peptides / Q000008:administration & dosage; D013116:Spinal Cord / Q000473:pathology; D014364:Tryptophan / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004676:Myelin Basic Protein; D010455:Peptides; D014364:Tryptophan