A schizophreniform behavioral psychosis mediated by dopamine.
The authors conducted a study in which schizophrenic-like behavioral disturbances were induced in members of a macaque social colony by the chronic administration of d-amphetamine. Animals given the drug showed hypervigilance, hyperactivity, fragmented and repetitive behaviors, and progressive social withdrawal as well as the development of solitary stereotypies. The syndrome was dissected pharmacologically with alpha-methyl-para-tyrosine, chlorpromazine, pimozide, and haloperidol. Based on the behavioral findings and the known mechanisms of action of these drugs, the authors conclude that the major elements of the psychotic-like behavior induced by d-amphetamine were mediated by dopamine systems.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D003913:Dextroamphetamine / Q000009:adverse effects*; D004195:Disease Models, Animal; D008251:Macaca; D011954:Receptors, Dopamine / Q000502:physiology*; D012559:Schizophrenia / Q000139:chemically induced* / Q000503:physiopathology
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D003913:Dextroamphetamine