A new alloantigenic system associated with the Mls locus in the mouse.
An antiserum prepared by injecting C3H/HeJ mice with CBA/J tissue has been shown to react with cell surface components that are not part of any previously described system of serologically detectable alloantigens. The antiserum, which is designated AST-101, acts selectively in cytotoxic tests carried out with lymphoid cells, killing B cells, but not T cells. Phagocytic cells found in peritoneal exudates are also killed by AST-101 and complement in vitro; the sensitivity of other cell types has not been determined. Strain distribution does not indicate any association of the AST-101 system with H-2, Ly, or Thy systems; genetic analysis reveals close linkage with the mouse minor MLC-stimulating (Mls) locus. Serologic analysis also points to a close association between antigens reactive with AST-101 and the products of the Mls genes.
D000818:Animals; D002874:Chromosome Mapping; D000939:Epitopes; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000302:isolation & purification; D007111:Immunity, Cellular; D007519:Isoantigens / Q000032:analysis*; D037102:Lectins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D000939:Epitopes; D007106:Immune Sera; D007519:Isoantigens; D037102:Lectins; D008070:Lipopolysaccharides