Cross-reactive T-cell antigens among mammalian species.
Fluoresceinated heteroantisera prepared against T cells of rats, monkeys, and humans were reacted withthymus and spleen cells from 11 selected species. These reagents recognized cross-reacting T cell antigen(s) among rodent species (mouse, rat, guinea pig, and hamster) and among primate species (monkey and humans). With one exception, the cross-reactivity was restricted to a phylogenetic order. All three antisera required relatively few absorptions to achieve T cell specificity for related species when compared to absorption requirements for the isologous species. Differentiation antigens within a phylogenetic order thus appear to be more homologous than other cell surface constituents on T cells.
D000042:Absorption; D000818:Animals; D000941:Antigens; D000961:Antilymphocyte Serum; D003429:Cross Reactions; D000939:Epitopes; D000882:Haplorhini; D006801:Humans; D011323:Primates; D051381:Rats; D012377:Rodentia; D013045:Species Specificity; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D000941:Antigens; D000961:Antilymphocyte Serum; D000939:Epitopes