Morphological characterisitcs of the pathological process in the central nervous system of monkeys infected with variants of measles virus strain L-16.
The neurovirulence of L-16 vaccine measles virus strains and its 9 clonal variants was investigated in intracerebrally infected Macaca mulatta monkeys. Two groups of clones were distinguished: one comprised variants that caused destructive changes of neurons in the brain and diffuse proliferative gliosis, and the second variants that caused changes of a transitory character, connected with the traumatic exposure.
D000818:Animals; D001921:Brain / Q000473:pathology*; D014644:Genetic Variation; D000882:Haplorhini; D008253:Macaca mulatta; D008457:Measles / Q000473:pathology*; D008458:Measles Vaccine; D008459:Measles virus / Q000235:genetics / Q000472:pathogenicity*; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology
D008458:Measles Vaccine