title: [2-14C-phenazepam metabolism in vitro].
abstract: Phenazepam undergoes aromatic and C3-hydroxylation in the microsomes of albino rats. Saturation of phenazepam oxidising enzymes proceeds at different substrate concentrations for both processes. Interaction of cytochrome P-450 with phenazepam is accompanied by spectral changes in the type II hemoprotein.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000032:analysis / Q000378:metabolism*; D001569:Benzodiazepines; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013053:Spectrophotometry
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Metabolizm 2-14C-fenazepama in vitro.