Probable identification of an HL-A second-locus antigen associated with a high risk of nasopharyngeal carcinoma.
An HL-A antigen profile comprising an increased frequency of HL-A2 and undetectable second-locus antigen(s) in Chinese patients with nasopharyngeal carcinoma (N.P.C.) has been reported. To investigate whether the deficit of second-locus antigen(s) had a genetic basis, sera from parous women in Singapore were screened for anti HL-A activity corresponding to the second-locus "bland". A second-locus (Singapore-2) was identified which seems to be associated with a high risk of N.P.C.
D000951:Antigens, Neoplasm / Q000302:isolation & purification; D001666:Binding Sites, Antibody; D005260:Female; D006680:HLA Antigens / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*; D011247:Pregnancy; D012703:Serotyping; D012846:Singapore
D000951:Antigens, Neoplasm; D006680:HLA Antigens; D006649:Histocompatibility Antigens