title: The endoscopic appearance of the duodenum in Whipple's disease.
abstract: Duodenoscopic examination of a patient with Whipple's disease revealed that the duodenal mucosa appeared to be partially covered with a yellow-white material. On closer inspection, however, this was found to consist of enlarged villi interspersed with normal-looking mucosa. Histologically these enlarged white villi were shown to contain a heavy accumulation of lipid and typical PAS positive macrophages. The duodenal mucosa was endoscopically normal and histologically showed only a few PAS positive macrophages one year after instituting antibiotic therapy.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004386:Duodenum / Q000473:pathology; D004724:Endoscopy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D008061:Whipple Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents