Erythrosin B inhibition of neurotransmitter accumulation by rat brain homogenate.
A mixture of seven food dyes inhibited the accumulation of eight neurotransmitters or neurotransmitter precursors by rat brain homogenate. At a low concentration (1 microgram per milliliter), erythrosin B (FD&C red 3) was the only dye that inhibited dopamine accumulation. Erythrosin also was effective in decreasing the accumulation of all the other transmitter substances, suggesting that the inhibition is nonspecific and probably secondary to general membrane alteration.
D000818:Animals; D002474:Cell-Free System; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism; D004923:Erythrosine / Q000009:adverse effects / Q000494:pharmacology*; D005452:Fluoresceins / Q000494:pharmacology*; D005505:Food Coloring Agents / Q000009:adverse effects / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D013569:Synapses / Q000187:drug effects*
D005452:Fluoresceins; D005505:Food Coloring Agents; D018377:Neurotransmitter Agents; D004923:Erythrosine; D004298:Dopamine