Possible cellular events in leukemia.
An immunologically unresponsive state induced in experimental animals can be modulated by a number of procedures. Such modulation can result in the termination of the unresponsive state if there exists a normal complement of immunocompetent B cells in the presence of unresponsive T cells. It is possible to bypass the T cells and activate the B cells to respond to otherwise tolerated antigens. The bypass results from supplying a second (nonspecific) signal to the B cells, which, in the presence of antigen (specific signal), permits the B cell to differentiate. The role of the T and B cells and their activation and/or inactivation in the fate of both leukemic cells and oncogenic viruses is discussed.
D000276:Adjuvants, Immunologic; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D001798:Blood Proteins / Q000276:immunology; D003429:Cross Reactions; D006087:Graft vs Host Reaction; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007938:Leukemia / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D005719:gamma-Globulins
D000276:Adjuvants, Immunologic; D001798:Blood Proteins; D011135:Polysaccharides, Bacterial; D012709:Serum Albumin; D005719:gamma-Globulins