Potentiation of the response of rat vas deferens to noradrenaline by dicylohexylamine and related amines.
The results of a previous study on protection by propranolol and dicyclohexylamine of alpha-blockade suggested that these compounds potentiated the response of the isolated rat vas deferens to noradrenaline. A number of structural analogues of dicyclohexylamine (DCHA) have now been investigated for their effects on noradrenaline responses and some of them have been shown to potentiate these responses. At concentrations approaching those necessary to achieve maximum potentiation they also brought about the spiked contraction of the vas deferens. The potentiating effects of these amines are discussed together with their relevance to the protection of alpha-blockade.
D000319:Adrenergic beta-Antagonists; D000588:Amines / Q000494:pharmacology*; D000818:Animals; D003514:Cyclohexylamines / Q000494:pharmacology*; D004357:Drug Synergism; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D000588:Amines; D003514:Cyclohexylamines; D009638:Norepinephrine