The relation of HL-A antigens to liver histology in methotrexate-treated psoriatics.
A total of 45 patients with severe psoriasis vulgaris treated with Methylaminopterin NFN (Methotrexate Lederle) were HL-A typed in order to seek a possible correlation between HL-A antigens and the histological abnormalities in post-Methotrexate (MTX) liver biopsies. Highly significantly increased frequencies of w17 and TY (P less than 0.0001) were found, while HL-A13 Was only slightly increased. No statistically significant correlations were found between HL-A antigens and liver histology. HL-A typing does not seem to be of any predictive value in the pre-MTX screening of psoriatics in order to rule out patients with a high risk of liver damage during long-term MTX therapy.
D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D008727:Methotrexate