title: Chemical modification of crude timothy grass pollen extract. I. Antigenicity and immunogenicity changes following amino group modification.
abstract: Glutaraldehyde modification was found to reduce the allergenic potency of crude timothy pollen extracts yet even highly substituted materials retained the capability of inducing the formation of allergen-specific antibody in animals. Experiments showed that these antibodies were capable of blocking skin test reactions to native timothy allergens in pollen-sensitive human volunteers. The value of glutaraldehyde-modified allergen extracts for use in desensitization vaccine therapy is discussed.
mesh_terms: D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D001667:Binding, Competitive; D000939:Epitopes; D005976:Glutaral / Q000494:pharmacology*; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006801:Humans; D010323:Passive Cutaneous Anaphylaxis; D010936:Plant Extracts / Q000276:immunology* / Q000494:pharmacology; D006109:Poaceae / Q000276:immunology*; D011058:Pollen; D051381:Rats; D012882:Skin Tests
chemical_list: D000447:Aldehydes; D000906:Antibodies; D000939:Epitopes; D010936:Plant Extracts; D005976:Glutaral