An explanation fro chloracne -- an industrial hazard.
Patients with chloracne were investigated and the results compared with data matched for age and site from patients with acne vulgaris. The ultrastructural appearances of pilo-sebaceous ducts in both groups were similar. The industrial group had significantly fewer C. acnes than the patients with ordinary acne. They also showed a significant increase in the surface lipid percentage composition of squalene, wax ester and cholesterol and this was associated with a significant decrease in the triglyceride free fatty acids and total triglyceride pool. We suggest that the acnegenic agent has produced its effect by modifying the metabolism of the pilo-sebaceous fluid.
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D009783:Dermatitis, Occupational / Q000139:chemically induced; D004781:Environmental Exposure; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000506:poisoning*; D050356:Lipid Metabolism; D008297:Male; D012627:Sebaceous Glands / Q000378:metabolism; D013185:Squalene / Q000378:metabolism
D006843:Hydrocarbons, Chlorinated; D013185:Squalene