title: Tienilic acid in mild to moderate hypertension.
abstract: Tienilic acid has blood pressure lowering properties alone and in combined treatment with beta-adrenergic blocking agents; 250 mg of tienilic acid seems to correspond to 50 mg of hydrochlorothiazide. Tienilic acid effectively reduces serum urate and has no marked or rapid effect on potassium balance. During short-term treatment, no impairment of glucose tolerance was found.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006016:Glycolates / Q000627:therapeutic use*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013989:Ticrynafen / Q000627:therapeutic use*; D014527:Uric Acid / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D006016:Glycolates; D006852:Hydrochlorothiazide; D014527:Uric Acid; D013989:Ticrynafen