[The influence of ritodrine-hcl (prepar), bunitrolol (stresson) and oxytocin (syntocinon) on Uteroplacental perfusion (author's transl)].
The administration of betamimetics has proved to be useful for symptom-oriented treatment in patients with reduced utero-placental flow. In order to quantify the betamimetic effect flow measurements were carried out in a total of 12 sheep, yielding the following experimental results: 1) Betamimetics, up to a certain point which correlates with maternal heart rate, raise the uteroplacental flow-rate. 2) The use of cardio-selective betablocker prevents undesired betamimetic side-effects but there is also a loss of the rise in utero-placental flow rate. 3) In sheep pretreated with Oxytoxin the application of betamimetics not only offsets oxytoxin-action but also greatly improves utero-placental blood flow.
D000818:Animals; D005260:Female; D006801:Humans; D010121:Oxytocin / Q000494:pharmacology*; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects; D011247:Pregnancy; D011412:Propanolamines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012312:Ritodrine / Q000494:pharmacology*; D012756:Sheep; D014599:Uterus / Q000098:blood supply* / Q000187:drug effects
D011412:Propanolamines; D010121:Oxytocin; D012312:Ritodrine
Der Einfluss von Ritodrine-HCl (Prepar), Bunitrolol (Stresson) und Oxytocin (Syntocinon) auf die uteroplazentare Perfusion.