Experimental autoimmune demyelinating diseases: experimental allergic encephalomyelitis and experimental allergic neuritis.
Experimental allergic encephalomyelitis (EAE) and experimental allergic neuritis (EAN) are reproducible models of auto-allergic demyelinating diseases of central and peripheral neurons tissue respectively. EAE bears a close resemblance to naturally-occuring post-infectious encephalomyelitis and EAN to Laundry-Guillain-Barré polyneuritis, in humans. In the experimental models the antigen responsible for disease induction is a different myelin basic protein in each disease. Although a variety of humoral antibodies to various neural fractions are found in both disorders, it has been shown that disease results from cell-mediated immune reactions to specific myelin antigens.
D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D004676:Myelin Basic Protein / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology; D011115:Polyneuropathies / Q000276:immunology*
D001323:Autoantibodies; D004676:Myelin Basic Protein