Differential enhancement of locomotor activity by dopamine agonists following chronic morphine treatment.
Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity which may be anatomically distinct in origin.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D004873:Ergolines / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D004873:Ergolines; D009020:Morphine; D001058:Apomorphine; D004298:Dopamine