Metronidazole for Crohn's disease.
Five patients with Crohn's disease for 4 months to 12 years were treated with metronidazole. Four of them improved after 2-4 weeks' treatment. In three of them corticosteroids and sulphasalazine could be withdrawn. One patient did not improve until 4 months of metronidazole treatment had passed and corticosteroids were reintroduced. In three patients metronidazole was discontinued after 4-6 months of treatment. Two of them had no signs or symptoms of relapse 3 and 6 months later. The third patient is free from symptoms but laboratory data indicate disease activity.
D000328:Adult; D002648:Child; D003424:Crohn Disease / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006941:Hyperesthesia / Q000139:chemically induced; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D010292:Paresthesia / Q000139:chemically induced; D011239:Prednisolone / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use
D008795:Metronidazole; D012460:Sulfasalazine; D011239:Prednisolone