title: Clinical and microbiological aspects of chemotherapeutic agents used according to the specific plaque hypothesis.
abstract: Certain forms of dental decay and periodontal disease appear to be due to specific bacterial infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypothesis, If so, then antimicrobial treatment based on a diagnosis of elevated levels or proportions of these organisms should be considered. Such treatment cannot be administered according to concepts of the non-specific plaque hypothesis. A treatment philosophy is presented which is based upon considerations long established in medical infections following overgrowth of certain indigenous plaque bacteria, i.e., the specific plaque hypomicrobial to the site of the infection for periods long enough to suppress or destroy the pathogenic agent. Examples of this treatment philosophy are given.
mesh_terms: D000190:Actinomyces / Q000187:drug effects; D000818:Animals; D018407:Bacterial Physiological Phenomena; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002710:Chlorhexidine / Q000494:pharmacology / Q000627:therapeutic use; D003731:Dental Caries / Q000188:drug therapy / Q000382:microbiology; D003773:Dental Plaque / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D005459:Fluorides / Q000627:therapeutic use; D005891:Gingivitis / Q000188:drug therapy; D006801:Humans; D009910:Oral Hygiene; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D001443:Prevotella melaninogenica / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations; D005459:Fluorides; D002710:Chlorhexidine