Stimulation of luteinising hormone (L.H.) release after oral administration of an analogue of L.H. releasing hormone.
An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly-NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.
D000284:Administration, Oral; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D013268:Stimulation, Chemical; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone