Fatty acid biosynthesis in Wallerian degeneration of rat sciatic nerve.
In-vitro fatty acid biosynthesis was studied in normal rat sciatic nerve and during wallerian degeneration. Normal nerve incorporated 1,3-C14-malonyl-CoA and 1-C14-acetyl-CoA into fatty acids by a de-novo biosynthetic pathway. The reaction product with highest radioactivity was palmitic acid, and the free fatty acids of nerve contained 90% of the total fatty acid label. During wallerian degeneration, there was a rapid increase of fatty acid biosynthesis that reached a peak between 16 and 24 days after nerve section. Values declined to normal levels at approximately 50 days.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D005227:Fatty Acids / Q000096:biosynthesis*; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000096:biosynthesis; D008316:Malonyl Coenzyme A / Q000378:metabolism; D009410:Nerve Degeneration; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012584:Sciatic Nerve / Q000378:metabolism*; D014855:Wallerian Degeneration
D000596:Amino Acids; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D008055:Lipids; D011506:Proteins; D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A