Studies on the cytophilic properties of human beta2 microglobulin.
Human beta2 microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more beta2 microblobulin than thymocytes although hydrocortisone-resistant thymocytes resemble spleen cells in this regard. The beta2 microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for beta2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.
D000818:Animals; D001001:Anura; D001402:B-Lymphocytes / Q000276:immunology; D001609:Beta-Globulins / Q000276:immunology* / Q000302:isolation & purification; D001666:Binding Sites, Antibody; D002645:Chickens; D004351:Drug Resistance; D006168:Guinea Pigs; D006649:Histocompatibility Antigens; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007106:Immune Sera; D007457:Iodine Radioisotopes; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009194:Myeloma Proteins / Q000302:isolation & purification; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous; D014426:Turtles; D014556:Urine / Q000032:analysis
D001609:Beta-Globulins; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007457:Iodine Radioisotopes; D009194:Myeloma Proteins; D006854:Hydrocortisone