title: Urinary metabolites from gamma- and beta-BHC in the mouse: chlorophenol conjugates.
abstract: Metabolites produced from gamma- and beta-BHC in the mouse urine were purified and characterized. Most metabolites from both isomers were not extractable by non-polar organic solvents and were conjugates such as sulfates and glucuronides. After hydrolysis with an appropriate enzyme, the conjugates gave chlorophenols, among which 2,4,6-trichlorophenol existed most abundantly (total, about 25% in the urine metabolites). 2,4-Dichlorophenol also constituted a significant portion.
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D005965:Glucuronates / Q000652:urine; D001556:Hexachlorocyclohexane / Q000378:metabolism / Q000652:urine*; D051379:Mice; D008815:Mice, Inbred Strains; D010636:Phenols / Q000652:urine*; D013237:Stereoisomerism; D013431:Sulfates / Q000652:urine; D013997:Time Factors
chemical_list: D005965:Glucuronates; D010636:Phenols; D013431:Sulfates; D001556:Hexachlorocyclohexane