[Clinical importance of antiprolactinaemic treatment of functional infertility (author's transl)].
Reported in this paper is the effectiveness of antiprolactinaemic treatment of 40 infertile women. All case histories revealed previous unsuccessful attempts to induce ovulation. Antiprolactinaemic treatment was in all cases preced by RIA determination of prolactin and gonadotrophin. Prolactin levels were found to be somewhat increase in 19 cases, while 21 women were normal. The gonadotrophin plasma levels usually were closer to the lower limits of normal values. The presence of hypophyseal adenoma had been ruled out beforehand. Long-time treatment was based on the administration of 5 mg Parlodel/die. The effect was excellent in all cases of hyperprolactinaemia, but response was recorded, as well, from a group of patients with normal prolactin levels. Galactorrhoea ceased to exist in all cases. Clomiphen was applied again to induce ovulation in those patients who had not responded at all or developed only bleeding without ovulation. That treatment proved to be effective in several cases.
D000328:Adult; D002986:Clinical Trials as Topic; D002996:Clomiphene / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood*; D011389:Prolactin Release-Inhibiting Factors / Q000627:therapeutic use*
D002996:Clomiphene; D011388:Prolactin; D011389:Prolactin Release-Inhibiting Factors
Die klinische Bedeutung der antiprolaktinämischen Behandlung bei der funktionellen Infertilität.