Specific anti-fibroblast cytotoxicity of antibodies to fibroblast surface antigen.
An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture of human serum containing SFA.
D000937:Antigen-Antibody Reactions; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005347:Fibroblasts / Q000276:immunology*; D006367:HeLa Cells / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D008545:Melanoma / Q000276:immunology
D000939:Epitopes; D007106:Immune Sera