[On the narco-hypnotic of o-chloro 2-phenyl ethyl allophanate (S. C. S. 100) in animal (author's transl)].
Oral administration of o-chloro 2-phenyl éthyl allophanate (S. C. S. 100) to male and pregnant, or not, female mice, to male and female rats, to male guinea-pigs and rabbits induces, according to tested doses and animal species, a reduction of motoricity, a state of sleepiness giving way to exterior solicitations, a loss of balance, a diminution of muscular tonus or a temporary loss of righting reflex going with narcosis and a reversible suppression of sensibility. The narco-hynoticaction of S. C. S. 100 qualitatively similar to that of secobarbital needs 1.5 to 3 times higher doses to appear and has a little longer latent period but without any excitation. The new synthesized molecule differs also from the barbiturate as its therapeutic index is 3 times more important which means a better maniability confirmed moreover in mouse after several repeated administrations of ED 50 doses of S. C. S. 100.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012631:Secobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D012631:Secobarbital; D014508:Urea
Sur les effets narco-hypnotiques qu'exerce l'o-chloro phényl-2 allophanate d'éthyle (S.C.S. 100) chez l'animal.