Effects of beta-adrenoceptor agonists on airway smooth muscle and on slow-contracting skeletal muscle: in vitro and in vivo results compared.
Ten beta-adrenoceptor agonists were examined with respect to a) relaxation of pilocarpine-contracted trachea and depression of contractions of the soleus muscle of the guinea-pig in vitro and b) counteraction of histamine-induced bronchospasm and depression of contractions of the soleus muscle of the cat in vivo. There was a close correlation between the results obtained in vitro and results obtained on the corresponding tissues in vivo in spite of the different species used. A close correlation was also observed between effects on airway smooth muscle and on the soleus muscle contractions in vitro as well as in vivo for all compounds examined.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D002415:Cats; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010862:Pilocarpine / Q000494:pharmacology; D013045:Species Specificity; D014132:Trachea / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D010862:Pilocarpine; D006632:Histamine