title: Immune response of guinea-pigs to chemically abbreviated prepatent Metastrongylus apri infection.
abstract: The effect of chemical abbreviation of the primary infection dose (PID) of 160 infective larvae of Metastrongylus apri on the immune status of the guinea-pig host was studied. The criteria used for assessing the status of immunity consisted of clinical manifestations following administration of a challenge infection dose (CID) of 800 infective larvae of M. apri, the rate of worm recovery 15 days post-CID and the rate of mortality following administration of CID. Among the guinea-pigs of the main experimental group, where 15-day-old PID was abbreviated by two parenteral doses of levamisole, a strong immunity to CID given 35 days post-PID was built-up. Against this, all the guinea-pigs of a control group, which did not receive PID, died between 16 and 22 days post-CID. The increase in serum gamma-globulin level of the guinea-pigs, where the PID was abbreviated chemically, suggested that the rise of this globulin fraction in the serum could be in some way related to the resistant state of guinea-pigs.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007109:Immunity; D008168:Lung / Q000469:parasitology; D008681:Metastrongyloidea / Q000276:immunology*; D009349:Nematode Infections / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology; D005719:gamma-Globulins / Q000032:analysis
chemical_list: D005719:gamma-Globulins