[On the absorption of decongestive nose-drops-investigation with a radioactive labelled imidazoline-derivate (author's transl)].
In animal experiments, the absorption of a nasal decongestive substance after application to the nasal mucosa was studied. After an exposition-time of 60 minutes, about 1% of the substance applied could be measured in the total blood volume. An incorporation of the substance into proteins of the nasal mucosa could not be found. By means of frozen-section-autoradiography, the way of the applied decongestive substance through the mucosa could be investigated. The reasons for the relative small absorption rate are discussed. The chemical structure and the vasoconstrictory effect probably are reliable for that.
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D000042:Absorption; D000818:Animals; D007093:Imidazoles / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D014663:Nasal Decongestants / Q000378:metabolism* / Q000494:pharmacology; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012996:Solutions
D007093:Imidazoles; D014663:Nasal Decongestants; D012996:Solutions; D015057:1-Naphthylamine
Zur Resorption abschwellender Nasentropfen