title: [Significance of metabolic parameters in Hodgkin's disease (author's transl)].
abstract: In 56 patients with Hodgkin's disease, the following bloodtests were carried out: erythrocyte sedimentation rate (ESR), fibrinogen, alpha2-globuline, serium iron concentrations and alkaline phosphatase activity. In some patients we additionally measured alkaline leucocyte phosphatase and serum ribonuclease activity. In our series ESR, serum iron and alpha2-globuline concentrations were the most sensitive metabolic parameters. A rise in fibrinogen concentration, alkaline phosphatase and serum ribonclease activity seems to indicate extensive disease. It is not possible, however, to discern between a state of remission and stage I by means of these parameters. ESR, serum iron and alpha2-globuline concentrations might be either elevated or normal in both instances. These parameters seem important in order to distinguish between a remission or stage I on the one hand and extensive disease in stage III and IV on the other hand. Concomitant findings of ESR above 40 mmh, elevated concentrations of fibrinogen and alpha2-globuline, as well as elevated alkaline phosphatase and serum and serum ribonuclease activity mostly indicate stage III or IV.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000510:Alpha-Globulins / Q000032:analysis; D001799:Blood Sedimentation; D005340:Fibrinogen / Q000032:analysis; D006689:Hodgkin Disease / Q000097:blood* / Q000473:pathology; D006801:Humans; D007501:Iron / Q000097:blood; D012075:Remission, Spontaneous; D012260:Ribonucleases / Q000097:blood
chemical_list: D000510:Alpha-Globulins; D005340:Fibrinogen; D007501:Iron; D012260:Ribonucleases; D000469:Alkaline Phosphatase
vernacular_title: Zur Bedeutung metabolischer parameter beim morbus Hodgkin