[Study of the nature of the antigens detectable in antiserum cross reactions to the milk antigens of patients with breast carcinoma and to the type D oncornavirus isolated from HEp-2 cells (author's transl)].
Antigens of milk from normal women and from patients with mammary gland carcinoma and antigens of D type virus from HEp-2 cells were studied by means of microprecipitation in the gel and indirect immunofluorecence tests. An antiserum to HEp2 virus precipitated antigens of some milk specimens from cancer patients. However their virus precipitated antigens of some milk specimens from cancer patients. However their precipitation line was not identical to that of the test-system for group-specific antigens and the antiserum to HE-2 virus detected an antigen localized in the cytoplasm in the following cells: HEp-2, continuous cell lines and imprints of human mammary gland cancer, and epithelial cells from milk of patients with mammary gland carcinoma and from milk of normal women. The antiserum for the antigen of milk from cancer patients absorbed with HEp-2 cell homogenate lost its activity in the IF test. The nature of the detected antigens is discussed.
D000951:Antigens, Neoplasm / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology*; D002277:Carcinoma / Q000276:immunology*; D002460:Cell Line; D002478:Cells, Cultured; D003429:Cross Reactions; D000939:Epitopes; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D005779:Immunodiffusion; D007158:Immunologic Techniques; D008895:Milk, Human / Q000276:immunology*; D009858:Oncogenic Viruses / Q000276:immunology* / Q000302:isolation & purification
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000939:Epitopes; D007106:Immune Sera
Izuchenie priorody antigenov, vyiavliaemykh v perekrestnykh reaktsiiakh antisyvorotkami k antigenam moloka bol'nykh kartsinomoĭ molochnoĭ zhelezy i onkornavirusu tipa D, vydelennomu iz kletok HEp-2