Supportive effect of simultaneous immunization to other H-antigens on the female response to male-specific antigen in mice.
The response of A-strain females to the male-specific antigen is very weak; both first- and second-set test skin grafts are rejected protractedly and about 50% of the grafts are retained in spite of generally present morphologic signs of cellylar immunity induced by these grafts. When the first-set skin graft involved H-incompatibilities additional to the MSA (such as H-2 only or H-2 plus multiple non-H-2) all the second-set grafts, which were only MSA-incompatible, underwent a markedly accelerated rejection. The possible mechanism of this adjuvant-like effect is discussed.
D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000939:Epitopes; D005260:Female; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D012737:Sex Factors; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000939:Epitopes; D006649:Histocompatibility Antigens