[The heart in hypertension. V. Systolic and diastolic wall stress and degree of hypertrophy as determinants of diagnostic and therapeutical consequences (author's transl)].
The appropriateness of hypertrophy was analyzed in 64 patients with essential hypertension during diagnostic cardiac catheterization and left ventriculography. The degree of hypertrophy may be described by the relationships between peak systolic pressure, mass to volume ratio and peak systolic wall stress. The peak systolic wall stress represents an important determinant of the appropriateness of hypertrophy and has great influence on left ventricular function and myocardial energy demand. The hypertrophy in essential hypertension may be subdivided into 3 different types of hypertrophy: (a) inappropriate hypertrophy associated with increased mass-to-volume ratio and decreased systolic wall stress, (b) appropriate hypertrophy with normal systolic wall stress and (c) inappropriate hypertrophy with normal or decreased mass-to-volume ratio, however with significantly increased systolic wall stress. On the basis of the appropriateness or degree of left ventricular hypertrophy in essential hypertension the therapeutical consequences are being discussed with special reference to beta receptor blockade and digitalis glycosides.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002306:Cardiac Volume; D006332:Cardiomegaly / Q000150:complications; D004071:Digitalis Glycosides / Q000627:therapeutic use; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D013312:Stress, Physiological; D013599:Systole
D000319:Adrenergic beta-Antagonists; D004071:Digitalis Glycosides
Das Hochdruckherz. V. Masse-Volumen-Relation, Wandspannungen und Hypertrophiegrad: Diagnostische und therapeutische Konsequenzen.