Pre-beta1-lipoprotein and Lp(a) antigen in relation to triglyceride levels and insulin release following an oral glucose load in middle-aged males.
A series of 30 previously investigated and presumably healthy middle-aged males have been studied, following an oral glucose tolerance test (OGTT). The insulin mean value 120 min after the start of the OGTT was found to be significantly lower in persons possessing the pre-beta1-lipoprotein (pre-beta1 +) and Lp(a) antigen, than in those who were pre-beta1-/Lp(a-). At 60 min during the OGTT, triglyceride and insulin correlated significantly in pre-beta1-/Lp(a-) individuals, but not in pre-beta1 + or Lp (a+) individuals; on the other hand, insulin correlated significantly with blood glucose at this time in the pre-beta1 + and Lp(a+) individuals, but not in the pre-beta1-/Lp(a-). These findings may reflect an important biochemical difference between the two subpopulations.
D000941:Antigens; D001786:Blood Glucose / Q000032:analysis; D000939:Epitopes; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008074:Lipoproteins / Q000276:immunology*; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
D000941:Antigens; D001786:Blood Glucose; D000939:Epitopes; D007328:Insulin; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides