Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell interactions to determinants linked together: suppression vs. enhancement.
The experiments presented in this paper demonstrate the existence of T-T cell interactions in responses to azobenzenearsonate (ABA)-protein conjugates, and also make the point that the spectrum of T-cell regulation from facilitation (i.e., help) at one end to suppression at the other, which has been well documented in T-B cell interactions, is also followed in T-cell regulation of other T lymphocytes. The data extend the activity of ABA-specific suppressor cells, which were shown to specifically suppress the development of delayed hypersensitivity to ABA-T, to T cells responsible for delayed hypersensitivity to protein antigens provided immunization is carried out with ABA conjugates of these antigens. Thus, suppressor T cells acting on the development of delayed hypersensitivity are not limited in their effects to T cells bearing the same specificity but can effectively suppress responses on immunologically unrelated T cells if they are specific for carrier antigens covalently linked to the ABA-T determinant. Moreover, these studies demonstrate that, as is true of T-B cell interactions, the most efficient T-T cell interactions occur to determinants linked together on the same molecule thus supporting the concept that development of effector T-cell function may involve participation of at least two distinct precursor cells, each of which may convey independent determinant specificities and/or genetic control.
D000818:Animals; D001555:Benzene Derivatives / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D000939:Epitopes; D005620:Freund's Adjuvant / Q000494:pharmacology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007074:Immunoglobulin G; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007271:Injections, Intradermal; D007428:Intradermal Tests; D008297:Male; D008968:Molecular Conformation; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D001555:Benzene Derivatives; D000939:Epitopes; D007074:Immunoglobulin G; D005620:Freund's Adjuvant