title: Treatment of attacks in hyperkalaemic familial periodic paralysis by inhalation of salbutamol.
abstract: In fifteen patients with hyperkalaemic familial periodic paralysis, inhalation of salbutamol alleviated hyperkaleamia and paralysis precipitated by exercise or oral administration of potassium chloride. In-vitro studies with rat soleus muscles indicated that the hypokalaemic effect of salbutamol is related to stimulation of the active coupled transport of sodium and potassium in muscle cells. Follow-up studies proved that the inhalation of salbutamol is a simple and adequate method for the treatment of the paralytic episodes in these patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002986:Clinical Trials as Topic; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D010245:Paralyses, Familial Periodic / Q000188:drug therapy* / Q000209:etiology; D005082:Physical Exertion; D011188:Potassium / Q000378:metabolism; D011189:Potassium Chloride / Q000009:adverse effects; D051381:Rats; D012964:Sodium / Q000378:metabolism
chemical_list: D000336:Aerosols; D010042:Ouabain; D011189:Potassium Chloride; D012964:Sodium; D000420:Albuterol; D011188:Potassium; D004837:Epinephrine