[Effect of a single dose of some long-acting neuroleptics on the estrus cycle and the mammary gland of the rat].
The effects of two neuroleptics (pipotiazine and fluphenazine) and five long-acting neuroleptics (pipotiazine undecylenate and palmitate, fluphenazine enanthate and decanoate, fluopentixol decanoate) are tested in the rat, during an observation period of 20 to 40 days following only one injection of compound. The compounds administered at three different and non toxic doses, are showing effects, the intensity and duration of which are different according to the dose and the compound: diestrus of pseudo-gestation or more than 15 days, hypertrophy of mammary gland, decreasing of the uterine weight. Some long-acting neuroleptics are active during more than forty days.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002208:Caproates / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005475:Flupenthixol / Q000031:analogs & derivatives / Q000494:pharmacology; D005476:Fluphenazine / Q000031:analogs & derivatives / Q000494:pharmacology; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010640:Phenothiazines / Q000031:analogs & derivatives / Q000494:pharmacology; D011247:Pregnancy; D011555:Pseudopregnancy; D051381:Rats; D013843:Thiazines / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects
D014150:Antipsychotic Agents; D002208:Caproates; D010640:Phenothiazines; D013843:Thiazines; C007761:flupenthixol decanoate; C023377:pipothiazine undecylenate; D005475:Flupenthixol; C011825:fluphenazine depot; C017610:fluphenazine enanthate; D005476:Fluphenazine
Effets d'une dose unique de quelques neuroleptiques à action prolongée sur le cycle estral et la glande mammaire de la ratte.