title: Comparison of the lytic effects of four prostaglandin analogues in the chacma baboon (Papio ursinus ursinus).
abstract: Six healthy, cycling female chacma baboons (Papio ursinus ursinus) were used to determine the luteolytic effects of four prostaglandin analogues. The compounds were administered according to a study design which made provision for adequate controls. Five to seven days following ovulation, venous blood was collected and the baboon given a single intramuscular injection of a compound at a recommended dose. Blood was then collected serially every 3 h for three samples and again at 24, 48, and 72 h to determine the continued effect of the prostaglandin analogues on corpus luteum production of progesterone. It was found that PGF2alpha-1,15-lactone, 11alpha(15S)-17-phenyl-18,19,20-trinor-ent-PGE2 methyl ester and 17-phenyl-18,19,20-trinor-PGF2alpha exhibited definite luteolytic potential in this species. Equivocal results were obtained with (15S)-15-methyl-PGF2Alpha THAM and its toxic qualities resulted in the demise of three animals.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D000882:Haplorhini; D007273:Injections, Intramuscular; D008186:Luteolytic Agents / Q000008:administration & dosage / Q000633:toxicity; D010215:Papio; D011374:Progesterone / Q000097:blood; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D008186:Luteolytic Agents; D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D011374:Progesterone