The influence of lindane on enzymes activity in the tissues of rats on protein rich diet.
Lindane in the dose of 1/10 LD50 given to rats on standard diet decreases the activity of 3.1.3.1. and 3.1.3.2. alkaline and acid phosphatases (AP and AcP) in blood serum, 2.6.1.1. glutamic oxalacetic transaminase (GOT), 2.6.1.2. glutamic pyruvic transaminase (GPT) in liver and 1.1.1.27 lactate dehydrogenase (LDH) in blood serum, kidney and liver. The same dose of lindane but given to rats on protein rich diet induces much stronger inactivation of the discussed enzymes, the stated differences being statistically significant. On determining LDH isoenzyme activity in homogenates from kidneys, no statistically significant differences were noted either in the groups treated with standard diet or those on protein rich diet, as compared with the controls not given lindane.
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004794:Enzyme Repression / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D000637:Transaminases / Q000097:blood
D004044:Dietary Proteins; D004791:Enzyme Inhibitors; D001556:Hexachlorocyclohexane; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase