Macrophage-lymphocyte interaction: antigen-independent binding of guinea pig lymph node lymphocytes by macrophages.
The antigen independent binding of guinea pig lymph node lymphocytes by glass-adherent macrophages was investigated. Binding was found to be mediated by a trypsin digestible, divalent cation-dependent, temperature-sensitive macrophage receptor mechanism that was not competitively inhibited by excess immunoglobulin. Data are presented to indicate that in the absence of antigen, macrophages were capable of binding both thymus-derived and bone marrow-derived lymphocytes without apparent selectivity, and further, that the binding of neither cell was mediated by surface membrane-associated immunoglobulin.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D001202:Ascitic Fluid / Q000166:cytology; D001665:Binding Sites; D002478:Cells, Cultured; D003078:Colchicine; D003165:Complement System Proteins; D003571:Cytochalasin B; D004492:Edetic Acid; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D010544:Peroxidases; D011817:Rabbits / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D012756:Sheep / Q000276:immunology; D013194:Staining and Labeling; D014357:Trypsin; D014747:Vinblastine
D000888:Antibodies, Anti-Idiotypic; D011947:Receptors, Antigen, B-Cell; D003571:Cytochalasin B; D014747:Vinblastine; D003165:Complement System Proteins; D004492:Edetic Acid; D010544:Peroxidases; D014357:Trypsin; D003078:Colchicine