Coexistence of protein AA and immunoglobulin light-chain fragments in amyloid fibrils.
Coexistence of amyloid fibril protein AA and homogeneous immunoglobulin light-chain fragments was found in the isolated amyloid fibrils of two patients with amyloidosis secondary to rheumatoid arthritis. The light-chain amyloid fibril protein showed antigenic identity with a light-chain amyloid from a patient with primary amyloidosis, which was identified as the VlambdaIV subgroup by amino acid sequence analysis. In the amyloid fibrils isolated from another patient with primary amyloidosis there was a mixture of VlambdaIV and VlambdaV homogeneous immunoglobulin light chains. Thus, a mixture of protein AA had lambda light chains or two different types of homogeneous light chains may be found in the amyloid fibrils of some patients.
D000595:Amino Acid Sequence; D000682:Amyloid / Q000031:analogs & derivatives* / Q000276:immunology; D000686:Amyloidosis / Q000276:immunology*; D002850:Chromatography, Gel; D000939:Epitopes; D006801:Humans; D007122:Immunoelectrophoresis; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis
D000682:Amyloid; D000939:Epitopes; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains