Determination of the minimum alveolar concentration (MAC) of aliflurane in dogs.
The minimum alveolar concentration (MAC) of aliflurane was measured in ten dogs. A value of 1.84 volumes per cent was determined, which correlates well with predictions based on lipid solubility. Induction of anesthesia and recovery were rapid, as would be anticipated with an agent of relatively low solubility in blood (blood-gas partition coefficient = 1.7). Circulatory responses over a relatively narrow range of aliflurane concentrations (0.8 to 1.4 MAC) remained stable, but the development of tachypnea, irregular ventilatory patterns, and increased muscle tone were frequently encountered during aliflurane anesthesis.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000032:analysis*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D003521:Cyclopropanes / Q000032:analysis*; D004285:Dogs; D005390:Fires / Q000517:prevention & control; D006339:Heart Rate; D006846:Hydrocarbons, Halogenated / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007442:Intubation, Intratracheal; D008297:Male; D011650:Pulmonary Alveoli / Q000032:analysis*
D000777:Anesthetics; D003521:Cyclopropanes; D006846:Hydrocarbons, Halogenated; D002245:Carbon Dioxide; C022572:aliflurane