The beta-adrenoceptors of the lung mediating inhibition of antigen-induced histamine release.
The beta-adrenoceptor stimulants, isoprenaline (IPR), orciprenaline (OPR), terbutaline (TRB), and ITP were studied for effects on antigen-induced release of histamine from guinea-pig lung tissue and for effects on guinea-pig isolated trachea and heart. The order of potency for the agents in the four funct-ons studied were: (a) inhibition of histamine release, IPR greater than OPR approximately equal to TRB greater than ITP equal 0; (b) heart stimulation, chronotropic effect, IPR greater than OPR greater than ITP approximately equal to TRB; (c) heart stimulation, inotropic effect, IPR greater than OPR greater than ITP greater than TRB; (d) trachea relaxation: IPR greater than TRB greater than OPR greater than ITP. These findings suggest that the beta-adrenoceptors mediating inhibition of antigen-induced release of histamine are more related to those mediating trachea relaxation (beta2) than those mediating cardiac stimulation (beta1).
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000707:Anaphylaxis / Q000378:metabolism; D000818:Animals; D000941:Antigens; D001013:Aorta, Thoracic / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D011941:Receptors, Adrenergic; D012110:Reserpine / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D000941:Antigens; D011941:Receptors, Adrenergic; D012110:Reserpine