Serum-high-density-lipoprotein and atherosclerotic heart-disease.
Serum-high-density-lipoprotein (H.D.L.) concentrations were determined in 49 men who had had a myocardial infarction and in 102 healthy, middle-aged men, all from Northern Sweden. A quantitative immunological assay based on a monospecific antiserum to the main polypeptide (apoprotein A-I) of H.D.L. was used. The mean H.D.L. concentration was significantly lower in the men with coronary heart-disease than in the controls. The results accord with the hypothesis that high levels of H.D.L. to some extent protect against ischaemic heart-disease.
D000328:Adult; D000368:Aged; D000818:Animals; D001059:Apoproteins / Q000276:immunology; D002784:Cholesterol / Q000097:blood; D002850:Chromatography, Gel; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D013552:Swine
D001059:Apoproteins; D007106:Immune Sera; D008075:Lipoproteins, HDL; D002784:Cholesterol