The behaviour of transporting epithelial cells. I. Computer analysis of a basic model.
We analyse the non-steady state behaviour of a computer model representing functional epithelial cells. The results show that a simple model of an epithelium, containing the essential ion transport asymmetries of the original Koefoed-Johnsen-Ussing model, predicts much of the observed behaviour of 'tight-type' epithelia under various well characterized experimental conditions.
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001001:Anura; D001692:Biological Transport / Q000187:drug effects; D002414:Cations, Monovalent / Q000378:metabolism; D002451:Cell Compartmentation; D002712:Chlorides / Q000378:metabolism; D003201:Computers; D004848:Epithelium / Q000378:metabolism*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D010042:Ouabain / Q000494:pharmacology; D012879:Skin Physiological Phenomena
D002414:Cations, Monovalent; D002712:Chlorides; D010042:Ouabain; D000584:Amiloride