title: Body fluid oxygen tension and prognosis in patients with ruptured aneurysm.
abstract: Body fluid gas pressure and electrolytes of patients with ruptured aneurysm were continuously analyzed. Intracranial pressure (ICP) was regulated at the level of 120-100 mm H2O by cerebral ventricular drainage. There was no significant change in the pH, PCO2, HCO3-, Na+, K+, Ca++ in the cerebrospinal fluid (CSF) of patients with slight or moderate disturbance of consciousness (lethargic-drowsy state). The PcsfO2 of the patients with marked disturbances of consciousness (semicoma-coma) was significantly low. PcsfO2 of the patients with cerebral vasospasm was significantly lower than for those without vasospasms. PcsfO2/PaO2 was 0.27 +/- 0.01 in the patients with vasospasm and 0.50 +/- 0.01 in those with vasospasm. PcsfO2 tended to decrease in patients with markedly bloody CSF. When the bloody CSF was cleared by ventricular drainage, PcsfO2 increased. PcsfO2 did not return to a normal value in the patients with marked disturbances of consciousness despite sufficient arterial oxygen tension. This suggests that PcsfO2 and PcsfO2/PaO2 should provide a convenient index for the prognosis of patients with ruptured aneurysm.
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000134:cerebrospinal fluid; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000209:etiology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid / Q000150:complications* / Q000503:physiopathology; D007427:Intracranial Pressure; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000134:cerebrospinal fluid*; D010313:Partial Pressure; D011379:Prognosis; D012422:Rupture, Spontaneous
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen