title: Blood substitutes.
abstract: With the development of modern methods of surgery, anaesthesia, and pre- and postoperative care the requirement for blood substitutes is continuously increasing. We present a review of the different blood substitutes which are already in clinical use or in an advanced stage of experimental investigation for possible practical administration. Our own clinical experience with dextrans and experimental studies on stroma-free haemoglobin and hydroxyethyl starch solutions are described.
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001810:Blood Volume; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use; D004573:Electrolytes / Q000627:therapeutic use; D004655:Emulsions; D004912:Erythrocytes; D005466:Fluorocarbons / Q000009:adverse effects / Q000627:therapeutic use; D005780:Gelatin / Q000494:pharmacology / Q000627:therapeutic use; D006454:Hemoglobins / Q000502:physiology; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology / Q000627:therapeutic use; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011205:Povidone / Q000627:therapeutic use
chemical_list: D003911:Dextrans; D004573:Electrolytes; D004655:Emulsions; D005466:Fluorocarbons; D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D005780:Gelatin; D011205:Povidone