title: Diazepam modification of evoked and spontaneous lateral geniculate activity.
abstract: The effects of diazepam on evoked and spontaneous activity of dorsal lateral geniculate nucleus (dLGN) principal (P) and inhibtory (I) cells were examined in rats. In the majority of P cells tested both spontaneous and evoked activity were suppressed following diazepam treatment with these effects being altered little by a pentylenetetrazol (Metrazol) challenge. In two P cells, which were offresponding to photic pulse stimulation, evoked and spontaneous activity was enhanced by diazepam but again these effects were altered little by the Metrazol challenge. I cell spontaneous activity was suppressed by diazepam and augmented by the Metrazol challenge; however, post-stimulus activity was relatively unaffected by either treatment. These results were discussed in terms of support for a functional re-evaluation of the rat dLGN.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects*; D005829:Geniculate Bodies / Q000166:cytology / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D051381:Rats
chemical_list: D003975:Diazepam