Subendocardial protection during cardiopulmonary bypass. Its use with methylprednisolone and glucose-insulin-potassium.
Fifteen adult dogs were equally divided into three groups: group 1 (control) received no medication before or after cardiopulmonary bypass (CPB), group 2 was administered glucose-insulin-potassium (GIK) according to Maroko's protocol before, during, and after CPB, whereas group 3 was treated with methylprednisolone (30 mg/kg) 30 minutes prior to and near the end of CPB. Moderately severe subendocardial hemorrhage was present in 80% of group 1, 50% of group 2, and only 20% of group 3 ventricles. Endocardial viability ratios after CPB were greater than 0.75 in 20% of group 1, 80% of group 2, and 100% of group 3 animals. Both GIK and steroids improved subendocardial perfusion after anoxic arrest and CPB compared with controls. However, steroid-treated dogs exhibited less endocardial hemorrhage, improved contractility, and more rapid return to baseline conditions than either GIK or control animals. These data suggests that steroids could be considered whenever normothermic anoxic cardiac arrest is used for cardiac operations.
D000818:Animals; D002315:Cardiopulmonary Bypass / Q000379:methods*; D004285:Dogs; D004359:Drug Therapy, Combination; D004699:Endocardium / Q000378:metabolism / Q000502:physiology*; D005947:Glucose / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000188:drug therapy; D007328:Insulin / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000627:therapeutic use; D011188:Potassium / Q000627:therapeutic use*
D007328:Insulin; D005947:Glucose; D011188:Potassium; D008775:Methylprednisolone