[Quantitative determination of glia-specific proteins in the cerebrospinal fluid of patients with MS (author's transl)].
150 cerebrospinal fluids from MS patients (85 cases) and patients with different neurological diseases (65 cases) were investigated for their glia-specific content. The demonstration was made quantitatively by means of modified passive hemagglutination tests. The brain-specific glycoprotein was examined for its possible endogenous antigen and/or antibody properties in the cerebrospinal fluid (csf). It could only be demonstrated in the CSF as antigen. CSF with a quantitatively detectable glia-specific protein content- recognizable by a significant increase in titer - were set in relation to other CSF parameters such as cell count, total protein and globulin ratio, and investigated for possible relationships to the clinical syndromes mentioned and their development. A firm correlation was found between the glia-specific protein content and the total protein content of the CSF with retained equivalence.
D000941:Antigens / Q000032:analysis; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D000939:Epitopes; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D009457:Neuroglia
D000941:Antigens; D002556:Cerebrospinal Fluid Proteins; D000939:Epitopes
Nachweis Glia-spezifischen Proteins im Liquor bei multipler Sklerose