title: Mesangial cell dysfunction detected by accumulation of aggregated protein in rats with streptozotocin induced diabetes.
abstract: Diminished renal glomerular mesangial phagocytic function has been found in rats with streptozotocin induced diabetes. Similar impairment was produced by high dose cortisone and growth hormone, whereas oestrogen had a stimulant effect. The findings could be relevant to the understanding of human diabetic nephropathy.
mesh_terms: D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism*; D005227:Fatty Acids / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism*; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D011489:Protein Denaturation; D051381:Rats; D013311:Streptozocin; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D005719:gamma-Globulins; D013311:Streptozocin; D013006:Growth Hormone; D003348:Cortisone