title: [Does lead contribute to the pathogenesis of spine disease?].
abstract: Statistical data of a public  insurance office of West Germany show a drastic increase  of the carriage impairments in juveniles. A plausible explanation of this phenomenon is presented by the lead quantities in auto exhaust. Present levels of environmentall lead produce a measurable biochemical alteration in the population of industrialized countries (inhibition of the activity of the enzyme ALAD). By disturbing the synthesis of nucleics acids and porteins lead impairs fundamental processes of life. Epidemiological and biochemical evidence for an influence of lead on the vertebral column and its diseases are brought forward.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000397:Air Pollution; D000818:Animals; D001847:Bone Diseases / Q000209:etiology / Q000662:veterinary; D001842:Bone and Bones / Q000378:metabolism; D002249:Carbon Monoxide Poisoning / Q000150:complications; D002908:Chronic Disease; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D005860:Germany, West; D006734:Horse Diseases / Q000209:etiology; D006736:Horses; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism; D007854:Lead / Q000494:pharmacology; D007855:Lead Poisoning / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051381:Rats; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology; D013122:Spinal Diseases / Q000453:epidemiology / Q000209:etiology* / Q000662:veterinary; D001335:Vehicle Emissions
chemical_list: D001335:Vehicle Emissions; D007854:Lead; D004492:Edetic Acid
vernacular_title: Spielt Bei eine Rolle in der Pathogenese der Wirbelsäulenleiden?