Evidence for a neuronal release of isotopically labelled gamma-amino-n-butyric acid (GABA) from the rat dorsal medulla in vivo.
High potassium and electrical stimulation consistently increase efflux of labelled GABA from the in vivo superfused rat dorsal medulla in a calcium-dependent fashion. The depolarizing alkaloid, veratridine, also evokes a large increase in efflux of labelled GABA. These data strongly suggest release from a neurotransmitter pool in this region.
D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D004558:Electric Stimulation; D005071:Evoked Potentials; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D014701:Veratridine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002712:Chlorides; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D014701:Veratridine; D011188:Potassium