Myo-inositol-1-phosphate synthase from streptomyces griseus (studies on the biosynthesis of cyclitols, XXXVIII).
It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.
D002238:Carbohydrate Epimerases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008970:Molecular Weight; D009154:Mutation; D007296:Myo-Inositol-1-Phosphate Synthase / Q000302:isolation & purification / Q000378:metabolism*; D013305:Streptomyces griseus / Q000201:enzymology* / Q000235:genetics
D002238:Carbohydrate Epimerases; D007296:Myo-Inositol-1-Phosphate Synthase