Adverse reactions following fazadinium-thiopentone induction.
Three cases of hypersensitivity to an anaesthetic induction with fazadinium and thiopentone are described. One reaction was fatal. Two patients had documented and the third presumptive previous exposure to thiopentone, and all had a history of allergy (skin rash) to penicillin. None of the patients had received fazadinium before. The possibility that fazadinium contributed to the severity of the reactions is conjectural.
D000368:Aged; D000771:Anesthesia, Intravenous; D001986:Bronchial Spasm / Q000139:chemically induced; D003165:Complement System Proteins / Q000032:analysis; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007022:Hypotension / Q000139:chemically induced; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011726:Pyridinium Compounds / Q000009:adverse effects*; D013874:Thiopental / Q000009:adverse effects*
D011726:Pyridinium Compounds; D007073:Immunoglobulin E; D003165:Complement System Proteins; D013874:Thiopental