[Cystostatic drug sensitivity testing of primary cultures of human tumours (author's transl)].
One to eight week-old primary tissue cultures of human tumours (1 rhabomysarcoma, 1 renal adenocarcinoma, 1 hymphogranuloma, 2 melanomas) and cultures of chicken embryo cells and HeLa-cells were tested for their sensitivity to chemotherapeutic agents. The drugs tested were: vincristine, actinomycin D, adriblastine, bleomycin. The drug effect was recorded by registration of morphological changes and, in some cultures by a change in the 3-H-thymidine incorporation. The cultures showed a variable reaction to vincristine, a good response to actinomycin D and adriblastine and were uniformly resistant to bleomycin. Two cultures were pulse labelled with 3-H-thymidine to obtain some data in regard to their growth characteristics.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology; D002478:Cells, Cultured; D003609:Dactinomycin / Q000494:pharmacology; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D009101:Multiple Myeloma / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000473:pathology; D013936:Thymidine / Q000378:metabolism; D014750:Vincristine / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D003609:Dactinomycin; D014750:Vincristine; D013936:Thymidine
Zytostatikatest an Primärkulturen von menschlichen Tumoren