[Determination of intravasal volume loss in arteria mesenterica superior shock in the rat and attempt for adequate substitution therapy].
In ams-shock of rats the weight of the small bowel contents of an animal 310 g of weight increases from 2.5 g to 13.0 g. The fluid loss into the bowel lumen amounts to 10.5 g and exceeds the plasma volume of 9.6 g. Drainage into the large bowel is not taken into consideration. After treatment of the ams-shock with gelatine infusion the weight of the small bowel wall increases significantly for a limited period of time to 3.2 g% body weight compared to normal controls with 2.3 g% body weight. After at least 24 hours the necrotic epithelium of the small bowel is fully recovered. Following ams-shock it is possible by means of gelatine infusion to improve the time and rate of survival significantly and to give support to the theory of volume loss.
D000818:Animals; D001810:Blood Volume; D001834:Body Water; D005780:Gelatin / Q000627:therapeutic use; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D007421:Intestine, Small / Q000473:pathology; D007511:Ischemia / Q000188:drug therapy; D008297:Male; D008638:Mesenteric Arteries / Q000503:physiopathology*; D051381:Rats; D012769:Shock / Q000188:drug therapy / Q000503:physiopathology*
D006895:Hydroxyethyl Starch Derivatives; D005780:Gelatin
Bestimmung des intravasalen Volumenverlustes beim Arteria mesenterica superior-Schock der Ratte und Versuche zur adäquaten Substitutionstherapie