Effect of age on amnesia and sedation induced by flunitrazepam during local anaesthesia for bronchoscopy.
Bronchoscopy was undertaken in 79 outpatients using local anaesthesia plus an i.v. injection of flunitrazepam 0.01 mg kg-1. The co-operation of the patients and the ease of bronchoscopy were good regardless of the age of the patient. There was an increase in amnesia for the bronchoscopy with increasing age, but the most distinct difference between different age groups was that the amnesic action of flunitrazepam was evident earlier and persisted longer in patients of more than 60 yr. Eye co-ordination and ability to stand steadily and walk on a line returned to normal more slowly in patients more than 60 than in those less than 60 yr, but no differences in recovery were noted between patients less than 40 and those of 40--59 yr, or between those 60--69 and those more than 70 yr.
D000328:Adult; D000368:Aged; D000375:Aging; D000647:Amnesia / Q000139:chemically induced*; D000772:Anesthesia, Local; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001999:Bronchoscopy; D005445:Flunitrazepam / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D011581:Psychological Tests; D013997:Time Factors
D014151:Anti-Anxiety Agents; D005445:Flunitrazepam