Reduced monocyte phagocytosis in patients with advanced Hodgkin's disease and lymphosarcoma.
The monocytes of 7 patients with advanced Hdgkin's disease (stages III and IV) and of two patients with generalized lymphosarcoma exhibited a highly significant impairment of the phagocytosis of IgG-coated red cells, regardless of receiving therapy or not.  In contrast three patients with M. Hodgkin, stage II B, and one with lymphosarcoma in complete remission showed a rather elevated monocyte phagocytic acitivity.  The nitroblue tetrazolium reduction by monocytes in the mean was significantly enhanced in all patients investigated, compared with normal persons, although only in one patient a bacterial infection was apparent at the time of the test.  The possible implication of the findings in the well known immunodeficiency present in M. Hodgkin and lymphosarcoma is discussed.
D002499:Centrifugation, Density Gradient; D004912:Erythrocytes / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D009000:Monocytes; D010587:Phagocytosis; D013194:Staining and Labeling
D007074:Immunoglobulin G