[Characteristics of the phlogistic action of melittin, its C-terminal fragment and some basic peptides in the rat paw (author's transl)].
Injection into the rat paw of either melittin, its C-terminal dekapeptide, tetralysine or triarginine causes an inflammatory response with melittin having the highest and the last mentioned peptides the lowest activity. The inflammatory action of melittin and the dekapeptide has the following characteristics: 1. it is mainly due to the liberation of histamine, since on both compounds the anti-histaminic diphenhydramine has a pronounced inhibitory effect; 2. di-sodium-cromoglycate inhibits only the inflammatory action of the dekapeptide but has no effect on the activity of melittin. Melittin and its fragment thus liberate histamine via different routes.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D004195:Disease Models, Animal; D006614:Hindlimb; D006636:Histamine Release / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced; D007509:Irritants; D008239:Lysine / Q000494:pharmacology; D008297:Male; D008555:Melitten / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D014688:Venoms / Q000494:pharmacology*
D007509:Irritants; D009842:Oligopeptides; D010446:Peptide Fragments; D014688:Venoms; D008555:Melitten; D001120:Arginine; D008239:Lysine; D004205:Cromolyn Sodium
Charakterisierung der entzündungserregenden Wirkung des Melittins, seines C-terminalen Fragments und einiger basischer Peptide an Rattenpfoten