title: The effect of antipsychotic drugs on body weight: a retrospective review.
abstract: Weight gain in schizophrenic patients during chemotherapy was first reported with chlorpromazine. Since then other antipsychotic drugs have exhibited this effect, while some have reduced weight. A retrospective review of 78 schizophrenic patients revealed that thiothixene, fluphenazine, haloperidol, and thioridazine produced a mean weight gain and loxapine a mean weight loss after 12 and 36 weeks of treatment. The ability of an effective antipsychotic drug, such as loxapine, to prevent weight gain or to produce weight loss offers a clinical advantage in the treatment of those schizophrenic patients where weight gain should be a problem.
mesh_terms: D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects*; D005476:Fluphenazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008152:Loxapine / Q000494:pharmacology; D012559:Schizophrenia / Q000188:drug therapy*; D013881:Thioridazine / Q000494:pharmacology; D013888:Thiothixene / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D013888:Thiothixene; D006220:Haloperidol; D008152:Loxapine; D013881:Thioridazine; D005476:Fluphenazine