Immunological and chemical correlation between alpha-fetoproteins from human and several mammalian species.
Alpha-Fetoproteins of several animals were purified and their molecular weights, amino acid compositions and peptide maps were compared, demonstrating the close similarities. These data indicated that the alpha-fetoproteins of mammalian species have closely related antigenical and chemical structures. Rabbits and horses were immunized with human alpha-fetoprotein, and it was observed that the animals produced antibodies reaction not only with human alpha-fetoprotein but with their homologous alpha-fetoproteins. The results were interpreted as the breakdown of the tolerance to their own alpha-fetoprotein.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002415:Cats; D002417:Cattle; D002645:Chickens / Q000276:immunology; D003429:Cross Reactions; D004285:Dogs / Q000276:immunology; D005326:Fetal Proteins / Q000276:immunology*; D006736:Horses / Q000276:immunology; D006801:Humans; D005779:Immunodiffusion; D051379:Mice; D008970:Molecular Weight; D010446:Peptide Fragments / Q000032:analysis; D011817:Rabbits / Q000276:immunology; D051381:Rats / Q000276:immunology; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D000509:alpha-Fetoproteins / Q000276:immunology*
D000596:Amino Acids; D005326:Fetal Proteins; D010446:Peptide Fragments; D000509:alpha-Fetoproteins