24-hour control of intragastric acidity by cimetidine in duodenal-ulcer patients.
The effects of two dose regimens of cimetidine on 24 h intragastric acidity were investigated in six patients with duodenal ulcer. They received placebo capsules on the first day and cimetidine on the second day. Cimetidine 0-8 g/day decreased 24 h mean H+ activity by 55% but 1-6 g/day decreased it by 67%, the difference being due to a greater nocturnal decrease in the high-dose group. Intragastric pH remained below 2-0 for much of the treatment day but similar values were found in four post-vagotomy patients. Cimetidine 0-8-1-6 g/day results in a decrease of intragastric acidity that is compatible with successful medical treatment of duodenal ulceration.
D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D005215:Fasting; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006146:Guanidines / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D010919:Placebos; D014628:Vagotomy
D005755:Gastrins; D006146:Guanidines; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D010919:Placebos