[Tumor hyperacidification through glucose infusion enhanced by local hyperthermia (author's transl)].
Local tumor hyperthermia (42--43 degrees C) during moderate whole body hyperthermia (40 degrees C) and hyperglycemia (5 . 10(-3) g ml-1) led to an amplification of tumor hyperacidification of deltapH = 0,47 +/- 0,19 In 12 from 20 animals. As cause of this phenomenon the stimulation of glycolysis by temperature increase (van't Hoff's law) and the stop of microcirculation by hyperthermia plus decrease of erythrocyte flexibility was discussed 5 tumors regressed totally.
D000818:Animals; D002296:Carcinosarcoma / Q000098:blood supply / Q000628:therapy*; D005947:Glucose / Q000627:therapeutic use*; D006358:Hot Temperature / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008297:Male; D008833:Microcirculation; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000628:therapy; D051381:Rats
D005947:Glucose
Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersäuerung durch lokale Hyperthermie.