Effect of taurine on release of 3H-GABA by depolarizing stimuli from superfused slices of rat brain cerebral cortex in vitro.
The effect of taurine on potassium (30 mM), veratrine (10 micrograms ml-1) and ouabain (100 microM) induced release of 3H-GABA from superfused slices of rat brain cerebral cortex had been studied. Taurine (10--100 mM) potentiated K+-induced release of 3H-GABA but was more potent in potentiating veratrine- and ouabain-induced release, having significant effects at 5 mM and 1 mM respectively. The potentiation of stimulus induced release does not appear to be due to inhibition of reuptake and the effect is consistent with both a 'modulatory' role and anticonvulsant action for taurine.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013654:Taurine / Q000494:pharmacology*; D014702:Veratrine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D009467:Neuromuscular Depolarizing Agents; D000625:Aminooxyacetic Acid; D013654:Taurine; D005680:gamma-Aminobutyric Acid; D010042:Ouabain; D014702:Veratrine; D011188:Potassium