Hypothesis: volatile anaesthetic agents enhance transplacental exchange between mother and fetus. A preliminary study of fetal scalp blood gas changes associated with enflurane anaesthesia.
A hypothesis that volatile anaesthetic agents, represented by enflurane, facilitate transplacental exchange was tested by simultaneous blood sampling of both mother and fetus. A trend towards improved fetal scalp blood gas status and maternal-to-fetal acid-base matching was observed with enflurane. Our results encourage further research into the feasibility of intra-uterine fetal resuscitation by anaesthetically induced promotion of intervillous perfusion.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D000769:Anesthesia, Inhalation; D000773:Anesthesia, Obstetrical; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008738:Methyl Ethers / Q000494:pharmacology*; D009609:Nitrous Oxide; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011674:Pulse / Q000187:drug effects
D008738:Methyl Ethers; D002245:Carbon Dioxide; D004737:Enflurane; D009609:Nitrous Oxide; D010100:Oxygen