Identification of additional antigenic sites on Dane particles and the tubular forms of hepatitis B surface antigen.
Additional antigenic sites, distinct from those present on spherical 20 nm diam. particles of hepatitis B surface antigen (HBsAg), are exposed on the surface of Dane particles and tubular forms of HBsAg. The immunological relationship of these sites to e-antigen, an antigen detected earlier in HBsAg-positive sera from patients with chronic hepatitis, cirrhosis or acute hepatitis but not in healthy HBsAg-carriers, was established by immune electron microscopy and affinity chromatography. These findings suggest that e-antigen may be potentially useful in active immunization against hepatitis B.
D000208:Acute Disease; D000818:Animals; D000936:Antigen-Antibody Complex; D002908:Chronic Disease; D000939:Epitopes; D006505:Hepatitis / Q000276:immunology*; D006511:Hepatitis B Antigens; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007106:Immune Sera; D008103:Liver Cirrhosis / Q000276:immunology*; D011817:Rabbits / Q000276:immunology
D000936:Antigen-Antibody Complex; D000939:Epitopes; D006511:Hepatitis B Antigens; D007106:Immune Sera