Protection of cattle against experimental haemorrhagic septicaemia by the capsular antigens of Pasteurella multocida, types B and E.
Aluminum hydroxide adjuvant vaccines containing endotoxin-free capsular antigens of Pasteurella multocida, types B and E, were administered to cattle. Dose dependent serological responses were observed which were similar for both antigens. The immunised cattle were subjected to intravenous challenge by a virulent type E strain. All animals which received the highest vaccine dose survived and all unimmunised control animals died and a vaccine dose-response relationship was obtained. The results of passive mouse protection and indirect haemagglutination tests (type E) on the sera of immunised cattle corresponded with the degree of protection against challenge of the cattle.
D000818:Animals; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D000939:Epitopes; D006386:Hemagglutination Tests; D006470:Hemorrhage / Q000662:veterinary; D007116:Immunization, Passive; D007279:Injections, Subcutaneous; D051379:Mice; D010325:Pasteurella / Q000276:immunology*; D010326:Pasteurella Infections / Q000276:immunology / Q000662:veterinary*; D018805:Sepsis / Q000662:veterinary*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D000939:Epitopes