The inhibition of cutaneous basophil hypersensitivity reactions by a heterologous anti-guinea pig T cell serum.
Systemic treatment with a heterologous anti-T cell serum of guinea pigs immunized with EA in IFA markedly suppressed CBH reactivity to specific antigen and T cell mitogens, as judged by gross reactivity, histology, and skin histamine. The antiserum produced a marked drop in circulating lymphocytes, mainly at the expense of T cells, as indicated by the ability of surviving lymphocytes to rosette with rabbit RBC. It was postulated that the suppression of CBH reactivity is due to the depletion of T cells, which would have released a factor chemotactic for basophils. The data therefore provide further evidence that cutaneous reactions rich in basophils are primarily dependent on a population of T cells.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001491:Basophils / Q000276:immunology*; D003208:Concanavalin A / Q000008:administration & dosage; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D007104:Immune Adherence Reaction; D037102:Lectins / Q000494:pharmacology; D007958:Leukocyte Count; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008934:Mitogens / Q000008:administration & dosage; D010047:Ovalbumin / Q000008:administration & dosage; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D037102:Lectins; D008070:Lipopolysaccharides; D008934:Mitogens; D003208:Concanavalin A; D010047:Ovalbumin