Histamine release by chemotactic, formyl methionine-containing peptides.
Certain formyl dipeptides and tripeptides containing methionine released histamine from human basophils at concentrations of 10(-4) to 10(-7) M. However, N-formyl amino acids did not release histamine. Tripeptides, in general, were more active than dipeptides. An acyl group was required for histamine release although an N-terminal position for Met was not essential. Histamine release from human basophils by these peptides correlated well with their chemotactic activity for rabbit leukocytes.
D000818:Animals; D001491:Basophils / Q000276:immunology; D002633:Chemotaxis; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits
D010455:Peptides; D009239:N-Formylmethionine; D008715:Methionine