Sendai virus multiplication in the presence of ceruloplasmin and homologous virus envelopes.
Preincubation of Sendai virus with ceruloplasmin induced in chorioallantoic membrane (CAM) fragments the synthesis of a population with decreased infectivity and high haemagglutinating (HA) and neuraminidase (NA) activities, whereas preincubation with solubilized virus envelopes led to the production of a viral population with the same infectivity as the control, but with lower HA and NA activities. Preincubation of the virus with a mixture of ceruloplasmin and solubilized envelopes depressed the overall virus synthesis; the resulting population had a low infectivity and high HA and NA activities. The variation in the HA/NA ratio indicates a modification in the envelope structure.
D000818:Animals; D002570:Ceruloplasmin / Q000494:pharmacology*; D002642:Chick Embryo; D046508:Culture Techniques; D005321:Extraembryonic Membranes; D006389:Hemagglutinins, Viral / Q000032:analysis; D009439:Neuraminidase / Q000032:analysis; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects* / Q000254:growth & development* / Q000276:immunology; D014764:Viral Proteins / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D002570:Ceruloplasmin; D009439:Neuraminidase