Enhancing effect of X-ray irradiation on a new blood vessel formation in mice tested by lymphocyte induced angiogenesis assay.
X-irradiation enhanced a new blood vessel formation occurring in the course of a local GvH reaction in mice. Maximal enhancing effect was exerted by single total body irradiation doses ranging from 700 to 1050 R. Fractionation in daily doses smaller than 200 R did not exhibit enhancing effect. Proliferative ability of angiogenesis inducing cells is not necessary for enhancing effect of irradiation.
D043925:Angiogenesis Inducing Agents / Q000032:analysis*; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006087:Graft vs Host Reaction / Q000528:radiation effects*; D006133:Growth Substances / Q000032:analysis*; D007158:Immunologic Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology* / Q000528:radiation effects; D051379:Mice; D012867:Skin / Q000098:blood supply; D013154:Spleen / Q000276:immunology; D014965:X-Rays
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances