[Storage of histamine in the blood following liberation from liver and antrum through trypsin: protective mechanism or a factor promoting pancreatic shock].
In dogs histamine was predominantly released from liver and antrum by intravenous injection of trypsin. The histamine content of the human liver was found to be high enough to allow the invasion of mg amounts of histamine into the circulation after histamine release. In blood histamine was rapidly taken up by corpuscular elements. At present it cannot be decided whether this mechanism leads to detoxification or to a more powerful action of histamine in the microcirculation.
D000818:Animals; D004285:Dogs; D005260:Female; D006632:Histamine / Q000097:blood / Q000494:pharmacology; D006636:Histamine Release; D008099:Liver / Q000378:metabolism*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010182:Pancreatic Diseases / Q000209:etiology* / Q000517:prevention & control; D011706:Pyloric Antrum / Q000378:metabolism*; D012769:Shock / Q000209:etiology* / Q000517:prevention & control; D014357:Trypsin / Q000378:metabolism
D006632:Histamine; D014357:Trypsin
Speicherung von Histamin im Blut nach Freisetzung aus Leber und Antrum durch Trypsin: protektiver Mechanismus oder Faktor in der Genese des pankreogenen Schocks