Regulation of the secondary antibody response in vitro. III.--inhibitor-containing cells of antigen stimulated rabbit lymph node organ cultures.
The existence of inhibitor cells influencing the immune response has been inferred in many recent studies employing mice or chickens. The mechanism of this presumed suppression is unknown. The present report describes the isolation of AIM (antibody inhibitory material) from migrant lymphoid cells which normally escape from fragements of rabbit lymph mode cultures. The RNAse activity of AIM was demonstrated and the implications of this property discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002478:Cells, Cultured; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000276:immunology*; D011817:Rabbits; D012260:Ribonucleases / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000276:immunology*; D014020:Tissue Extracts / Q000494:pharmacology; D005719:gamma-Globulins
D014020:Tissue Extracts; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine; D012260:Ribonucleases