Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations.
A case of acute monocytic leukemia (AMoL) studied by cytologic, histologic, cytochemical, ultrastructural, and cytogenetic technics is reported. The immature monocytes were characterized by strong fluoride-sensitive nonspecific esterase activity. Nuclear irregularity, prominent nucleoli, erythrophagocytosis, and pinocytosis were observed on transmission electron microscopy, whereas broad-based ruffles, similar to those found on normal monocytes, were identified with scanning electron microscopy. Cytogenetic analysis showed an 8/9 translocation and four or five identical 8p- marker chromosomes in most bone marrow cells.
D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology / Q000648:ultrastructure; D013194:Staining and Labeling; D014178:Translocation, Genetic