Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate.
A recent study by Kling et al (1978) noted the finding of higher lithium concentrations in serum and brain of rats after an intraperitoneal injection (2 mmol lithium kg-1) of lithium orotate as a slurry than of lithium carbonate in solution. The authors suggested that lithium orotate might offer advantages in the treatment of patients. We repeated the experiments of Kling et al but in addition examined the kidney function of the rats. Glomerular filtration rate and urine flow were markedly lower in rats given lithium orotate than in rats given lithium carbonate, sodium chloride or a sham injection. The renal lithium clearance was significantly lower, the kidney weight and the lithium concentrations in serum, kidney and heart significantly higher after injection of lithium orotate than after injection of lithium carbonate. The higher lithium concentrations could be accounted for by the lower kidney function. It seems inadvisable to use lithium orotate for the treatment of patients.
D000818:Animals; D002254:Carbonates / Q000378:metabolism / Q000494:pharmacology; D003404:Creatinine / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008094:Lithium / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009963:Orotic Acid / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D014018:Tissue Distribution
D002254:Carbonates; D009963:Orotic Acid; D008094:Lithium; D003404:Creatinine