Local treatment of recent arterial thromboembolic occlusions with brinase.
Brinase was administered intra-arterially in 16 patients with thrombotic or embolic arterial occlusions. Angiography could be performed before and after treatment in 13 patients. Thrombolysis was obtained in 3 of 9 patients with thrombotic and in 3 of 4 patients with embolic occlusions. In 3 patients severe local side effects occurred.
D001794:Blood Pressure / Q000187:drug effects; D001954:Brinolase / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011859:Radiography; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010447:Peptide Hydrolases; D001954:Brinolase