[The morphogenesis of chronic synovitis in rheumatoid arthritis].
The synovial sheath obtained in synovectomy in 35 patients with rheumatic- and rheumatic-visceral forms of rheumatoid arthritis was studied histochemically and immunomorphologically. At early stages of exacerbation of the pathological process in the synovial tissue there were revealed predominantly catabolic processes: an increased permeability of vessels; mucoid oedema; fibrinoid changes in the subintimal layer. Further development of the disease was characterized by predominance of anabolic processes with proliferation of synoviocytes, subintimal histiocytes, productive vasculites, massive lymphoid-plasmocytic infiltration, diffuse, or in the form of lymphoid follicles. Using the immunofluorescent technique the authors revealed luminescence of the rheumatoid factor and gamma=globulin in plasmatic cells, extracellularly, and more rarely in macrophages. Pronounced immunological changes in the synovial sheath in the active course of rheumatoid arthritis were accompanied by a high level of metabolic processes and an intensive phagocytic reaction in synoviocytes and subintimal histiocytes. In observations with a low activity of rheumatoid arthritis the synovial tissue was characterized by low levels of enzymes of oxidative metabolism and hydrolysis, emptying of the capillary bed, processes of sclerosis, hyalinosis, amyloidosis.
D000135:Acid Phosphatase / Q000378:metabolism; D000232:Adenofibroma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D002199:Capillary Permeability; D002908:Chronic Disease; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology; D011859:Radiography; D012217:Rheumatoid Factor / Q000378:metabolism; D013583:Synovial Membrane / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D013585:Synovitis / Q000201:enzymology / Q000209:etiology* / Q000276:immunology; D005719:gamma-Globulins / Q000378:metabolism
D006025:Glycosaminoglycans; D005719:gamma-Globulins; D012217:Rheumatoid Factor; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Morfogenez khronicheskogo sinovita pri revmatoidnom artrite