Effects of repeated oral doses of demethylchlortetracycline on bones and dentin of young rhesus monkeys.
Seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. Bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. Cessation of bone growth and its duration could be correlated with serum levels.
D000284:Administration, Oral; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D003707:Demeclocycline / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003804:Dentin / Q000187:drug effects* / Q000378:metabolism; D005269:Femur / Q000187:drug effects; D005624:Frontal Bone / Q000187:drug effects; D007275:Injections, Intravenous; D007854:Lead / Q000008:administration & dosage; D008253:Macaca mulatta; D008297:Male; D008334:Mandible / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010294:Parietal Bone / Q000187:drug effects; D013194:Staining and Labeling
D007854:Lead; D003707:Demeclocycline