Separation of drugs by high-performance liquid chromatography with porous polymer resins.
The separation of cold drugs and neuroleptics by high-performance liquid chromatogarphy with the porous polymer resin DVB-MCL-O (or 11-30-0), which is a styrene-divinylbenzene-methyl methacrylate copolymer substituted with hydroxymethyl groups, was studied. This copolymer was compared with the commercial porous polymers Hitachi gel 3011, 3011-0 and 3030. A very small theoretical plate height was obtained by using DVB-MCL-O and methanol-ammonia solution (99:1) as the stationary and mobile phases, respectively. This combination was found to be the most suitable for the rapid separation of condensed aromatic ring compounds.
D000700:Analgesics; D014150:Antipsychotic Agents / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D011108:Polymers; D012117:Resins, Synthetic
D000700:Analgesics; D014150:Antipsychotic Agents; D004364:Pharmaceutical Preparations; D011108:Polymers; D012117:Resins, Synthetic