Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats.
The intraperitoneal injection of apomorphine (APO) or N-n-propyl-norapomorphine (NPA) to adult male rats markedly increases the incidence of episodes of penile erection (PE). The effect is dose related for a dose range of APO from 25 to 500 microgram kg-1 and NPA from 1.25 to 50 microgram kg-1. Higher doses are progressively less effective until 1 and 5 mg kg-1 of APO and NPA, respectively, suppress even the natural occurrence of PE. APO differs from NPA not only on a potency basis but also in that doses of APO which elicit stereotypy no longer evoke PE, while a wide range of doses of NPA (12.5 to 500 microgram kg-1) produces simultaneously strong PE activation and stereotypy. The sexual stimulant response to APO and NPA is prevented by haloperidol (0.3 mg kg-1) and sulpiride (50 mg kg-1) but is not affected by domperidone (3 mg kg-1), an inhibitor of extracerebral dopamine receptors.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001058:Apomorphine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D010413:Penis / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; C009074:N-n-propylnorapomorphine; D001058:Apomorphine