title: Combination chemothereapy with cis-diamminedichloroplatinum (II) and bleomycin in tumors of the head and neck.
abstract: 28 patients with head and neck tumors not suitable for definitive treatment with radiation or surgery were treated with cis-diamminedichloroplatinum (II) and bleomycin in combination. Of 24 adequately treated patients, there were 3 partial remissions lasting for 3,3 and 6 months, respectively. Toxicity of the regimen as given was substantial; 13 patients showed some evidence of nephrotoxicity and there were 2 drug deaths related to progressive renal failure. 1 patient developed bleomycin pulmonary toxicity.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006311:Hearing Disorders / Q000139:chemically induced; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D007958:Leukocyte Count; D008171:Lung Diseases / Q000139:chemically induced; D009325:Nausea / Q000139:chemically induced
chemical_list: D001761:Bleomycin; D002945:Cisplatin