Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs.
To find out if growth-hormone release-inhibiting hormone (G.H.-R.I.H.) had any direct action on gastric acid production independent of its effect on gastrin release, cyclic G.H.-R.I.H. was infused at a rate of 20 mug. per kg. per hour into dogs with gastric fistulae. Gastric acid output fell sharply in response to three stimuli acid production--a meal and pentagastrin and histamine infusions. The fact that acid output was inhibited during pentagastrin administration suggests that G.H.-R.I.H. has a direct action on the gastric parietal cell.
D000821:Animal Feed; D000818:Animals; D004285:Dogs; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D007263:Infusions, Parenteral; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013004:Somatostatin; D006632:Histamine; D010418:Pentagastrin