title: Blood eosinophil leucocyte and eosinophil cationic protein. In vivo study of the influence of beta-2-adrenergic drugs and steroid medication.
abstract: The in vivo effect of beta-2-adrenergic stimulating and blocking drugs and of corticosteroid medication on blood eosinophils and serum eosinophil cationic protein (S-ECP) has been studied. The beta-2-adrenergic drugs, salbutamol and terbutaline, had an eosinopenic effect. They were able to decrease S-ECP concentration, which administration of steroid was not, indicating that only the adrenergic stimulators affect leucocyte secretion. Care must be taken in interpretation of blood eosinophil count and S-ECP concentration, and the actual medical treatment must be known.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D001249:Asthma / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced; D011239:Prednisolone / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013726:Terbutaline / Q000494:pharmacology
chemical_list: D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D001798:Blood Proteins; D011239:Prednisolone; D011433:Propranolol; D013726:Terbutaline; D000420:Albuterol