Cerebral metabolic and hemodynamic activities of l-eburnamonine in the anesthetized dog. A comparison with vincamine.
1. The cerebral metabolic and hemodynamic activities of l-eburnamonine (l-E) were investigated in anesthetized dogs and compared with those of vincamine (Vi). 2. The injection of l-E (2 mg/kg i.v.) increased vertebral, carotid and femoral blood flows (VBF, CBF, FBF) while corresponding resistances decreased. aortic blood flow (A0 BF) and systolic ejection volume (SEV) increased. Cerebral O2 and glucose consumption (CMRO2, CMRG) increased as did the O2 extraction coefficient and the O2 supply. This last increase was due to the simultaneous increase of VBF, hemoglobin (Hb) and arterial pO2.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004285:Dogs; D005260:Female; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014749:Vincamine / Q000494:pharmacology*
D006454:Hemoglobins; D014748:Vinca Alkaloids; D002245:Carbon Dioxide; D014749:Vincamine; D005947:Glucose