The alpha-adrenoceptor control of adrenocorticotropin secretion in man.
Oral administration to six normal male volunteers of an alpha-adrenoceptor agonist, guanfacine (4 mg daily for 4 days) had no significant effect on ACTH release induced by metyrapone (a single oral 1-g dose). The same treatment with guanifacine significantly reduced ACTH secretion stimulated by insulin-induced hypoglycemia in another group of six male volunteers. These results indicate that, in man, the adrenergic system has an inhibitory input on stress-induced ACTY secretion via alpha-adrenoceptors. The concept of alpha-adrenergic control of ACTH secretion in man is in agreement with some experimental in vivo and in vitro data recorded in animals.
D000316:Adrenergic alpha-Agonists; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005246:Feedback; D006146:Guanidines; D006801:Humans; D007003:Hypoglycemia / Q000503:physiopathology; D007328:Insulin; D007700:Kinetics; D008297:Male; D008797:Metyrapone; D010648:Phenylacetates; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D001786:Blood Glucose; D006146:Guanidines; D007328:Insulin; D010648:Phenylacetates; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D000324:Adrenocorticotropic Hormone; D008797:Metyrapone