Induction of tolerance to nucleic acid determinants by administration of a complex of nucleoside D-glutamic acid and D-lysine (D-GL).
The administration of nucleosides coupled covalently to the copolymer of D-glutamic acid and D-lysine (D-GL) or to its stereoisomer, L-GL, induces a state of nucleoside (NUC)-specific tolerance in inbred SJL and BALB/c mice, irrespective of their immune status at the time of treatment. Such tolerance is characterized by the inability of treated animals to mount either primary or secondary, intact or adoptive, anti-NUC antibody responses following immunization with a highly immunogenic conjugate of NUC-Keyhole limpet hemocyanin. These observations have potential therapeutic importance in autoimmune processes involving anti-DNA antibody production.
D000818:Animals; D000974:Antibodies, Antinuclear; D000917:Antibody Formation; D000939:Epitopes; D005971:Glutamates / Q000276:immunology*; D006433:Hemocyanins / Q000276:immunology; D007108:Immune Tolerance; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007116:Immunization, Passive; D007117:Immunization, Secondary; D008239:Lysine / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008974:Mollusca / Q000276:immunology; D009696:Nucleic Acids / Q000276:immunology; D009705:Nucleosides / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000939:Epitopes; D005971:Glutamates; D009696:Nucleic Acids; D009705:Nucleosides; D006433:Hemocyanins; D008239:Lysine