Intracytoplasmic hyaline globules in hepatocellular carconomas.
Intracytoplasmic hyaline globules (IHG) were found in 16 out of 105 hepatocellular carcinomas (15.2%). In all cases, there was a male preponderance, most of the patients were Black, and the mean age was in the fifth decade. IHG were mostly noted in the better-differentiated tumors. Bile production was present in 12% of all tumors. Over 80% of tumors with globules showed necrosis as compared with 40% of the tumors without globules. Cirrhosis was present in almost half the cases, with liver cell dysplasia in 15%. These globules are possibly alpha-fetoprotein. Some of them may be giant lysosomes. Their role in carcinogenesis and prognosis is uncertain.
D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology*; D005260:Female; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D006818:Hyalin / Q000648:ultrastructure*; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D019896:alpha 1-Antitrypsin Deficiency; D000509:alpha-Fetoproteins / Q000032:analysis
D006511:Hepatitis B Antigens; D000509:alpha-Fetoproteins