Studies with Brugia pahangi. 18. Anthelmintic effects of stibocaptate.
Stibocaptate (Asiban, Hoffman--La Roche) killed third stage larvae of Brugia pahangi in vitro at 50 p.p.m. but had no effect on microfilariae at 1 X 10(4) p.p.m No larvae developed in infected mosquitoes fed 1% stibocaptate in 10% sucrose. It was neither micro-nor macrofilaricidal in either jirds or cats but did affect embryogenesis.
D000818:Animals; D000965:Antimony / Q000494:pharmacology*; D002009:Brugia / Q000187:drug effects*; D002415:Cats; D009033:Culicidae / Q000469:parasitology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005370:Filarioidea / Q000187:drug effects*; D008297:Male; D009942:Organometallic Compounds; D004113:Succimer; D013386:Succinates / Q000494:pharmacology*
D009942:Organometallic Compounds; D013386:Succinates; D000965:Antimony; C004443:stibocaptate; D004113:Succimer