[Effect of antihistaminics on bradykinin action].
On isolated ileum of the guinea pig the antihistamine drugs dimedrol, diprazin (pipolphen), tavegil and suprastin diminished spasmogenic effects of bradykinin and an enhancement of microvascular permeability induced by this polypeptid. The antihistamine drugs display a nonspecific antibradykinin activity. No relationship between the chemical structure and pronounced antibradykinin action of the antihistamines studied was revealed.
D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001920:Bradykinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D002974:Clemastine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D005029:Ethylenediamines / Q000494:pharmacology; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007082:Ileum / Q000098:blood supply; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010640:Phenothiazines / Q000494:pharmacology; D011398:Promethazine / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011727:Pyridinolcarbamate / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology
D000631:Aminopyridines; D001559:Benzhydryl Compounds; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D011725:Pyridines; D011759:Pyrrolidines; C004664:chloropyramine; D011727:Pyridinolcarbamate; D004155:Diphenhydramine; D002974:Clemastine; D011398:Promethazine; D001920:Bradykinin
Vliianie antigistaminnykh preparatov na éffekty bradikinina.