Blocking the encephalitogenic activity of the C-terminal part of the basic myelin protein in rabbits by treatment with serum.
Peptides HNB-92-169 and 116-169, tyr, derivatives of the C-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (EAE). Dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with Freund's complete adjuvant (FCA) abrogated their disease-inducing activity. Dissolving them in homologous or autologous serum only slightly affected the encephalitogenicity.
D000818:Animals; D000941:Antigens; D001769:Blood; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D004676:Myelin Basic Protein; D011817:Rabbits
D000941:Antigens; D004676:Myelin Basic Protein