Effects of some neuroleptic drugs on aggressive behavior in isolated mice.
Effects of some neuroleptic drugs on aggressive behavior in isolated mice. Acta Physiol. Pol. 1979, 30 (2): 295--298. Albino-Swiss male mice were isolated for 28 days and their isolation-induced aggressive behavior was tested after housing them in groups. The effects of the following neuroleptics were investigated: spiroperidol (0.2 mg/kg i.p.), pimozide (1 and 2 mg/kg i.p.), and clozapine (2 and 5 mg/kg i.p.). Among the drugs examined the strongest inhibitory action on the isolation-induced aggressive behavior was inserted by spiroperidol. Primozide and closapine had weaker, but significant anti-aggressive effect.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003024:Clozapine / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D010868:Pimozide / Q000494:pharmacology; D013134:Spiperone / Q000494:pharmacology
D014150:Antipsychotic Agents; D010868:Pimozide; D013134:Spiperone; D003024:Clozapine