[Is it possible to predict experimentally the anti-inhibitory action of some neuroleptics?].
Shortening of behavioural despair in mice, test that Porsolt and coll. have proposed for the screening of anti-depressive drugs, is able to reveal thymoanaleptic and/or desinhibitory properties of several neuroleptic-desinhibiting substances such as thioproperazine, carpipramine and sulpiride.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004336:Drug Antagonism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010640:Phenothiazines / Q000494:pharmacology; D012149:Restraint, Physical; D013469:Sulpiride / Q000494:pharmacology; D013976:Tiapamil Hydrochloride / Q000494:pharmacology
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D010640:Phenothiazines; D013469:Sulpiride; D013976:Tiapamil Hydrochloride
L'action désinhibitrice de certains neuroleptiques est-elle prévisible expérimentalement?