Slow-reacting substance of anaphylaxis:  studies on purification and characterisation.
We have demonstrated the role of arachidonic acid and lipoxygenase in the genesis of SRS-A and the possible role of lipoxygenases in its metabolism. SRS-A has been purified in microgram quantities together with closely related material. We have identified 5,12 di-hydroxy-6, 8, 10, 14 eicosatetranenoic acid released by antigen challenge, and which we feel is related to SRS-A. Further structural work is in progress.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D012898:Autacoids / Q000302:isolation & purification / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D005227:Fatty Acids / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D008084:Lipoxygenase / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D014132:Trachea / Q000187:drug effects
D001095:Arachidonic Acids; D012898:Autacoids; D005227:Fatty Acids; D008084:Lipoxygenase; D007213:Indomethacin