title: [Mitochondrial transhydrogenase: general principles of functioning].
abstract: A new mechanism for the functioning of mitochondrial transhydrogenase has been proposed. This mechanism makes it possible, without additional postulates, to explain the generation of delta muH+ of different signs in the forward and reverse transhydrogenase reactions and why this generation is not accompanied by the membrane uncoupling. It is suggested that the reduced nicotinamide rings of NADH and NADPH participate in a relay transfer of H+ ions across the membrane, while the oxidized nicotinamide rings of NAD+ and NADP+ block the H+-transporting paths in the transhydrogenase.
mesh_terms: D000818:Animals; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000201:enzymology; D007700:Kinetics; D008928:Mitochondria / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D009247:NADH, NADPH Oxidoreductases
vernacular_title: Mitokhondrial'naia transgidrogenaza: obshchie printsipy funktsionirovaniia.