The frequency of chromosome aberrations in tall men with special reference to 47, XYY and 47, XXY.
All men born during the years 1944-1947 to mothers who were inhabitants of Copenhagen when they gave birth, were identified. The adult heights of all but 2,552 of these 31,438 men were obtained; a group of 4,591 men at least 184 cm tall were selected for examination. Samples for chromosome studies were obtained from 4,139 (90.2%) of these tall men. A total of 41 (1%) abnormalities were identified (33 sex chromosome abnormalities, including 12 XYYs (0.3%) and 16 XXYs (0.4%), 6 autosomal abnormalities, and two of uncertain origin). The XYY and XXY groups were taller than the selected sample of tall XY men.
D000328:Adult; D001827:Body Height; D002869:Chromosome Aberrations; D002986:Clinical Trials as Topic; D003718:Denmark; D006801:Humans; D007621:Karyotyping; D008297:Male; D012728:Sex Chromatin / Q000648:ultrastructure; D012729:Sex Chromosome Aberrations / Q000453:epidemiology*; D012730:Sex Chromosomes; D013194:Staining and Labeling