title: An outbreak of hepatitis associated with intravenous injection of factor-VIII concentrate.
abstract: An outbreak of jaundice associated with three out of four batches of a commercial brand of freeze-dried factor-VIII concentrate occurred at the Bournemouth haemophilia centre between April and June, 1974. Seven cases of non-B hepatitis and four of hepatitis B occurred within 6 months of the first use of this product. Two patients contracted both types of hepatitis; thus nine patients became ill out of a total of twenty regularly seen at the centre, eighteen of whom received commercial factor-VIII concentrate.
mesh_terms: D000914:Antibodies, Viral / Q000302:isolation & purification; D004196:Disease Outbreaks; D004739:England; D005169:Factor VIII / Q000008:administration & dosage*; D006506:Hepatitis A / Q000209:etiology* / Q000276:immunology; D006509:Hepatitis B / Q000209:etiology* / Q000276:immunology; D006511:Hepatitis B Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007275:Injections, Intravenous; D007565:Jaundice / Q000209:etiology; D065227:Transfusion Reaction
chemical_list: D000914:Antibodies, Viral; D006511:Hepatitis B Antigens; D005169:Factor VIII