Local tissue effects of surface-applied ENT drugs.
Local tissue effects caused by a selected group of topically applied ENT-drugs are analysed. By means of a testing system consisting of vital mircoscopy, infrared thermography and microangiography applied to hamsters and rabbits, an evaluation of the varying degree of tissue injury is made. According to the degree of tissue damage the tested substance could be graded in three groups (I-III). The drugs belonging to group I show fairly little microcirculatory disturbance, while those belonging to group III cause tissue necrosis. Our conclusion is that topically applied drugs should be used with caution, especially on previously injured tissues.
D000792:Angiography; D000818:Animals; D001414:Bacitracin / Q000494:pharmacology; D002610:Cheek / Q000098:blood supply; D002701:Chloramphenicol / Q000494:pharmacology; D006224:Cricetinae; D003864:Depression, Chemical; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D008619:Mepivacaine / Q000494:pharmacology; D008622:Merbromin / Q000494:pharmacology; D008833:Microcirculation / Q000187:drug effects*; D009061:Mouth Mucosa / Q000098:blood supply / Q000187:drug effects; D009278:Naphazoline / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology; D010109:Oxymetazoline / Q000494:pharmacology; D010118:Oxytetracycline / Q000494:pharmacology; D011817:Rabbits; D012836:Silver Proteins / Q000494:pharmacology; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D013501:Surface-Active Agents / Q000494:pharmacology*; D013634:Tannins / Q000494:pharmacology; D013817:Thermography; D014221:Triamcinolone / Q000494:pharmacology
D007093:Imidazoles; D012836:Silver Proteins; D013501:Surface-Active Agents; D013634:Tannins; D001414:Bacitracin; D014221:Triamcinolone; D002701:Chloramphenicol; D010109:Oxymetazoline; D008619:Mepivacaine; D009278:Naphazoline; D009355:Neomycin; D008622:Merbromin; D006854:Hydrocortisone; D010118:Oxytetracycline