title: Toxicology of clobazam.
abstract: 1 Extensive toxicological investigations of clobazam are summarized. 2 LD50 values after oral administration ranged from 100 mg/kg in the dog to 6000 mg/kg in the rat. 3 Long-term repeated dose studies have shown withdrawal effects in the dog and monkey (notably convulsions leading to death), similar to those known to occur with other benzodiazepines. 4 It is concluded that the overall safety and tolerability of clobazam have been demonstrated in the preclinical animal studies.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000633:toxicity*; D001569:Benzodiazepines; D004285:Dogs; D005260:Female; D005298:Fertility / Q000187:drug effects; D006168:Guinea Pigs; D000882:Haplorhini; D007928:Lethal Dose 50; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D012737:Sex Factors; D013045:Species Specificity; D013723:Teratogens
chemical_list: D014151:Anti-Anxiety Agents; D013723:Teratogens; D001569:Benzodiazepines