title: Clues to cancer risk: biologic markers.
abstract: Two large kindreds manifesting the "cancer family syndrome" have been studied. Genetic and biologic studies reveal markers which have important implications for cancer detection, control and prevention. Valuable markers may be found in the major histocompatibility system, HL-A. The presence of carcinoembryonic antigen and SV-40 viral transformation of skin fibroblasts are other possibly important markers. Relationships of the ABO blood groups to cancer are under intensive study, as is the hepatitis-associated antigen.
mesh_terms: D000017:ABO Blood-Group System / Q000302:isolation & purification; D000483:Alleles; D000510:Alpha-Globulins / Q000302:isolation & purification; D000951:Antigens, Neoplasm / Q000302:isolation & purification*; D002116:Calcitonin / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000302:isolation & purification*; D002471:Cell Transformation, Neoplastic; D046508:Culture Techniques; D005326:Fetal Proteins / Q000302:isolation & purification; D005347:Fibroblasts; D005770:Gastrointestinal Neoplasms / Q000276:immunology; D006680:HLA Antigens; D006511:Hepatitis B Antigens / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009101:Multiple Myeloma / Q000276:immunology; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D011083:Polycyclic Compounds; D011230:Precancerous Conditions; D013539:Simian virus 40; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism
chemical_list: D000017:ABO Blood-Group System; D000510:Alpha-Globulins; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D005326:Fetal Proteins; D006680:HLA Antigens; D006511:Hepatitis B Antigens; D011083:Polycyclic Compounds; D002116:Calcitonin; D006899:Mixed Function Oxygenases