Immunoglobulin E in rectal mucosa of patients with proctitis.
Rectal-biopsy specimens were obtained from a group of patients with proctitis in different stages of activity. Large numbers of brightly fluorescent IgE-producing cells were demonstrated in rectal-biopsy specimens taken from these patients during disease activity and clinical remission. An immediate hypersensitivity reaction is suggested as one of the mechanisms involved in the pathogenesis of proctitis.
D001706:Biopsy; D006801:Humans; D006969:Hypersensitivity, Immediate; D007070:Immunoglobulin A / Q000302:isolation & purification; D007073:Immunoglobulin E / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D007413:Intestinal Mucosa / Q000276:immunology*; D011349:Proctitis / Q000276:immunology*; D012007:Rectum / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E