title: Visualisation of thrombi with technetium-99m urokinase. A negative report.
abstract: Direct imaging of thrombi with isotopically labelled agents would provide a convenient atraumatic method of diagnosing deep venous thrombosis. Urokinase labelled with technectium-99m has many theoretical advantages and successful use of this agent has been reported. A method for tagging urokinase with Tc-99m has been developed which preserves the clot-lysing ability of the urokinase. The thrombus imaging previously reported has not been duplicated.
mesh_terms: D000208:Acute Disease; D010450:Endopeptidases; D005069:Evaluation Studies as Topic; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007553:Isotope Labeling; D007866:Leg / Q000098:blood supply; D010690:Phlebography; D011877:Radionuclide Imaging; D013667:Technetium / Q000008:administration & dosage; D013924:Thrombophlebitis / Q000175:diagnosis*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
chemical_list: D013667:Technetium; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator