Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole.
Twenty-one women were studied who had received propylthiouracil or methimazole during 26 pregnancies. Four of the infants had a goiter at birth, and 3 of these had neonatal thyrotoxicosis. In 2 children neonatal thyrotoxicosis was not evident at birth because of maternal antithyroid therapy. Five children had congenital defects. Two mothers were responsible for 4 of the children with abnormalities, and both mothers had been treated with thiourea drugs for long periods, ranging from 7 to 11 years. The majority of children who are exposed to these drugs in utero appear to have no subsequent ill effects. However, prolonged therapy with these agents may be undesirable.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005313:Fetal Death / Q000139:chemically induced; D006042:Goiter / Q000139:chemically induced; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D008135:Long-Acting Thyroid Stimulator / Q000032:analysis; D008297:Male; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D012535:Scalp / Q000002:abnormalities; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood
D008713:Methimazole; D011441:Propylthiouracil; D008135:Long-Acting Thyroid Stimulator; D013974:Thyroxine