Investigation of DNA-content of leukoplakia cells or oral mucosa.
DNA-histograms of smears of 11 plain leukoplakias, one of a precancerous leukoplakia, three of leukoplakia carcinoma in early stage, and one of a keratotic seqamous cell carcinoma of the floor of the mouth were prepared. The cell nuclei of the plain leukoplakia are mostly diploid, a small proportion has a DNA-content of 4 C. Intermediate values or polyploid nuclei are absent. In precancerous leukoplakia, intermediate values were noticed; in the cases of carcinoma in early stage, intermediate and polyploid nuclei were present, and in one case only polyploid nuclei. Only 2C and 4C nuclei occurred in a case of keratotic squamous cell carcinoma, which in comparison to earlier examined cases must be termed DNA negative.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003581:Cytodiagnosis; D004247:DNA / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis; D004171:Diploidy; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology*; D008010:Lichen Planus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology; D009060:Mouth Floor / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology; D010212:Papilloma / Q000032:analysis; D011123:Polyploidy; D011230:Precancerous Conditions / Q000473:pathology; D013194:Staining and Labeling
D004273:DNA, Neoplasm; D004247:DNA