Urinary polyamine levels in human cancer.
Polyamine levels (putrescine, spermidine, spermine) were determined in 24-hour urine samples by a high voltage electrophoresis technique. Normal values were established in 42 normal volunteers. Thirty-eight of 56 patients with metastatic cancer had two or more levels elevated. Approximately two-thirds of patients with metastatic adenocarcinoma, metastatic squamous cell cancer or metastatic disease to the liver, lings, or bones had elevated levels. All 6 patients with localized malignant tumors had elevated urinary polyamine levels. Elevations were also seen in patients with benign prostatic hypertrophy and bronchial adenoma.
D000230:Adenocarcinoma / Q000652:urine; D000236:Adenoma / Q000652:urine; D001859:Bone Neoplasms / Q000652:urine; D001943:Breast Neoplasms / Q000652:urine; D001984:Bronchial Neoplasms / Q000652:urine; D002294:Carcinoma, Squamous Cell / Q000652:urine; D003110:Colonic Neoplasms / Q000652:urine; D004586:Electrophoresis; D008113:Liver Neoplasms / Q000652:urine; D008175:Lung Neoplasms / Q000652:urine; D008297:Male; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000652:urine*; D011073:Polyamines / Q000652:urine*; D011470:Prostatic Hyperplasia / Q000652:urine; D011700:Putrescine / Q000652:urine; D013095:Spermidine / Q000652:urine; D013096:Spermine / Q000652:urine
D011073:Polyamines; D013096:Spermine; D013095:Spermidine; D011700:Putrescine