The neurology of vitamin B12 deficiency. Metabolic mechanisms.
The widely held view that the neurological and haematological complications of vitamin-B12 deficiency have different metabolic mechanisms appears unsound. It is suggested that the metabolic mechanisms involved are similar and that the neurological manifestations are the result of a secondary disturbance in folate metabolism as has already been postulated for the megaloblastosis.
D000752:Anemia, Pernicious / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D005492:Folic Acid / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D009420:Nervous System / Q000378:metabolism; D009422:Nervous System Diseases / Q000209:etiology*; D009461:Neurologic Manifestations; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D012075:Remission, Spontaneous; D013118:Spinal Cord Diseases / Q000209:etiology; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000378:metabolism*
D005492:Folic Acid