Further studies on the influence of calf alpha-globulin on survival of skin allografts in mice.
A single injection of 10 mg of alpha-globulin fraction isolated from calf serum prolonged survival of skin allografts in mice provided the preparation was injected two days before grafting. An immunosuppressive effect was also obtained by injecting alpha-globulin in a total dose of 13 mg in the second week after grafting in mice pretreated with antithymocyte serum; On the other hand, such an effect was not obtained when alpha-globulin was injected in the early days after grafting in doses of up to 25 mg per mouse.
D000510:Alpha-Globulins / Q000494:pharmacology*; D000818:Animals; D002417:Cattle / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D007109:Immunity / Q000528:radiation effects; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011830:Radiation Effects; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D000510:Alpha-Globulins