[Possible quantification of vascularization and of non-proliferating, hypoxic and nerotic proportions of lung cancer in man (author's transl)].
In hematoxylin-eosin stained quatorial sections of 14 human bronchial tumors, the relative proportions of different tissue elements were determined in two perpendicular planes, 500 and 200 mu wide, using the target principle. Data characterizing the level of necrotization of these tumors have revealed a poor supply of oxygen and nutritive substances to tumors in which large stroma areas were alternating with large fields of tumor parenchyma. As anticipated, necrotization increases with increasing size of the tumor. A network of narrow stroma strips in the tumor affords a more favourable supply of the cells. The proportions of necrotic, hypoxic and GO areas were calculated.
D001808:Blood Vessels / Q000473:pathology*; D001984:Bronchial Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008938:Mitosis; D009336:Necrosis; D010101:Oxygen Consumption; D013194:Staining and Labeling
Untersuchungen zur quantitativen Erfassung der Vaskularisierung und der nicht proliferierenden, hypoxischen und nekrotischen Anteile menschlicher Bronchialkarzinome