Influence of some anti-inflammatory, antipyretic and analgesic agents on urinary enzyme level in rats.
The influence of single oral dose of anti-inflammatory, antipyretic and analgesic agents on urinary enzymes was investigated in rats as a indicator of nephrotoxic effect. Urinary LDH activity was significantly elevated by aspirin, ketophenylbutazone, aminopyrine, phenacetin and acetaminophen. These drugs increased also H/M ratio of LDH isoenzymes. Although other test drugs have no effect on LDH in urine phenylbutazone and indomethacin elevated GPT and A1-P, oxyphenbutazone did gamma-GT and anthranilic acid derivatives did Al-P and gamma-GT. Other drugs such as sodium salicylate, ibufenac, ibuprofen, bucolome, aminopropylone, sulfinpyrazone, benzydamine and mepirizole did not significantly influence any enzyme activities measured in urine.
D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology; D004798:Enzymes / Q000652:urine*; D007213:Indomethacin / Q000494:pharmacology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008297:Male; D008628:Mercury / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology; D051381:Rats; D012459:Salicylates / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001463:Barbiturates; D004798:Enzymes; D007527:Isoenzymes; D010648:Phenylacetates; D012459:Salicylates; D062367:ortho-Aminobenzoates; D007770:L-Lactate Dehydrogenase; D008628:Mercury; D007213:Indomethacin