title: Fesults of the failure to perform adequate preclinical studies before administering new drugs to humans.
mesh_terms: D000818:Animals; D002386:Cataract / Q000139:chemically induced; D002715:Chlormadinone Acetate / Q000633:toxicity; D003280:Contraceptives, Oral, Synthetic / Q000633:toxicity; D004232:Diuretics / Q000633:toxicity; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D004983:Ethanolamines / Q000633:toxicity; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity; D007880:Legislation, Drug; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced; D051381:Rats; D013424:Sulfanilamides / Q000009:adverse effects; D014308:Triparanol / Q000506:poisoning / Q000633:toxicity; D014481:United States; D014486:United States Food and Drug Administration; D014665:Vasodilator Agents / Q000009:adverse effects / Q000633:toxicity
chemical_list: D003280:Contraceptives, Oral, Synthetic; D004232:Diuretics; D004983:Ethanolamines; D007166:Immunosuppressive Agents; D013424:Sulfanilamides; D014665:Vasodilator Agents; D002715:Chlormadinone Acetate; D014308:Triparanol