In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs.
D000631:Aminopyridines; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D006993:Hypnotics and Sedatives; D051379:Mice; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011738:Pyrilamine; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*
D000631:Aminopyridines; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011738:Pyrilamine