beta-Adrenergic regulation of adenosine 3',5'-monophosphate concentration in brain microvessels.
Norepinephrine increases the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the beta receptors, but the alpha-adrenergic agonist phenylephrine is without effect; beta-adrenergic blockade abolishes the response while alpha-adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002196:Capillaries / Q000294:innervation / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D013565:Sympatholytics; D000242:Cyclic AMP; D009638:Norepinephrine