[Shy and Drager syndrome. Physiopathological and pharmacological approach based upon one case (author's transl)].
The authors report a new case of Shy and Drager syndrome characterized by the severity of the extrapyramidal signs as well as that of orthostatic hypotension and urinary dysfunction. Peripheral adrenergic disturbance was proven, associated with an abnormality of the renin-angiotensin system. The authors describe the various drugs tried experimentally in treatment of the three main symptoms of the disease. A combination of Trihexyphenidyl and Dibenzepine finally appeared to be the most effective. Six months later, there remained a marked improvement in extrapyramidal signs and orthostatic hypotension. By contrast there was no improvement in urological symptoms.
D001480:Basal Ganglia Diseases / Q000188:drug therapy / Q000503:physiopathology*; D003984:Dibenzazepines / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014282:Trihexyphenidyl / Q000627:therapeutic use; D014555:Urination Disorders / Q000188:drug therapy / Q000503:physiopathology*
D003984:Dibenzazepines; D014282:Trihexyphenidyl
Syndrome de Shy et Drager. Approche physiopathologique et pharmacologique à propos d'un cas.