Leukaemia-associated antigen in serum of patients with acute lymphoblastic leukaemia.
A antigen (HThy-L) previously found in extracts of human thymocytes and leukalphaemic cells was detected in sera from four patients with E-rosette-positive untreated acute lymphoblastic leukalphaemia (A.L.L.) and one patient with previously treated acute myelogenous leukaemia (A.M.L.) The disappearance HYth-L angignaplhaemia with treatment was coindent with a decrease in the number of leukaemic blast cells in the peripheral blood. HThy-L antigen was not detected in the sera of the remaining twenty-one patients with E-rosette-negative A.L.L. and seven patients with A.M.L..
D000293:Adolescent; D000818:Animals; D000951:Antigens, Neoplasm / Q000302:isolation & purification*; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002648:Child; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D007106:Immune Sera; D007945:Leukemia, Lymphoid / Q000097:blood / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000276:immunology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D013949:Thymus Extracts / Q000276:immunology
D000951:Antigens, Neoplasm; D007106:Immune Sera; D013949:Thymus Extracts