[Comparative study of the action of tranquilizers on reinforcement systems].
In experiments on rats the benzodiazepine tranquilizers diazepam (0.5 -- 1 mg/kg), nitrazepam (0.5 -- 5 mg/kg), phenazepam (0.5 -- 5 mg/kg) and grandaxin (5 mg/kg) facilitated the reaction of self-stimulation (RS), with electrodes implanted in the area of the lateral hypothalamus and medial fascicle of the forebrain. Increased doses of the tranquilizers (up to 10 mg/kg) depressed RS, diminished the searching activity and muscle tone. The tranquilizer elroquil belonging to the phenothiazine series depressed RS in doses 15--35 mg/kg. Diazepam (0.2 and 1 mg/kg), nitrazepam (0.2 and 0.5 mg/kg) and phenazepam (0.2 and 1 mg/kg) reduced the latent period of the reaction of active avoidance (RA) during aversive electric stimulation of the medial lemnisk. In doses of 10 mg/kg the drugs inhibited RA. Elroquil and grandaxin raised the latent period of RA within the dosage range studied. The drug effects and efficacious dose ranges varied among the tranquilizers.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects; D010640:Phenothiazines; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D010640:Phenothiazines; D001569:Benzodiazepines
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