Ischaemic heart-disease: possible genetic markers.
National death-rates from ischaemic heart-disease are significantly correlated with population frequencies of histocompatibility antigen HLA-8 and haplotype 1-8. Serum-cholesterol levels may also be correlated with population frequencies of HLA-8. Inexplicably high death-rates from ischaemic heart-disease and high levels of serum-cholesterol in Finland may be due to the combined effects of HLA-8 and W15. It is suggested that HLA-8 (and possibly W15) are linked to genes which predispose to hypercholesterolaemia and ischaemic heart-disease. These findings provide some support for i-munogenetic hypotheses for vascular disease in man.
D001327:Autoimmune Diseases / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D005260:Female; D005796:Genes; D006680:HLA Antigens / Q000302:isolation & purification*; D006238:Haploidy; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D002784:Cholesterol