title: HLA-DW3 associated with coeliac disease.
abstract: 28 patients with coeliac disease (C.D.) were typed for the HLA-A, -B, and -D loci by several techniques. It was found that C.D. is primarily associated with the DW3 determinant and only secondarily with HLA-B8. The previously described association with HLA-B8 is explained by linkage disequilibrium between HLA-B8 and DW3.
mesh_terms: D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens