Swimming capacity of mice after prolonged treatment with psychostimulants. III. Effect of fencamfamine on swimming endurance and availability of metabolic substrates.
The effect of long-term treatment with fencamfamine on swimming endurance and availability of metabolic substrates was investigated in mice. Fencamfamine (14 micrograms/g per day orally for 6 weeks) reduced maximum swimming capacity by more than 40%. This effect could not be attributed to motor incoordination or a diminution of pre-swimming levels of metabolic substrates such as liver and muscle glycogen or blood glucose and non-esterfied fatty acids. However, during swimming the hepatic and muscular glycogen stores were depleted more rapidly in the fencamfamine-treated animals. Thus it appears that fencamfamine leads more rapidly to a shortage of combustible substrates in the swimming animals.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D051379:Mice; D009132:Muscles / Q000378:metabolism; D009636:Norbornanes / Q000494:pharmacology*; D010807:Physical Endurance / Q000187:drug effects*; D013550:Swimming
D001786:Blood Glucose; D000697:Central Nervous System Stimulants; D005230:Fatty Acids, Nonesterified; D008112:Liver Glycogen; D009636:Norbornanes; D006003:Glycogen; C020900:fencamfamine