title: Antigenic relationship between the fourth component of human and guinea pig complement.
abstract: Antigenic similarity between cell-bound human and guinea pig C4 was detected with antisera specific for each of these molecules. No cross-reaction could be detected between C4 of normal guinea pig or human sera or after treatment of the sera with antigen-antibody C1 complexes. The cross-reactivity between cell-bound human and guinea pig C4 may reflect conformational changes in the C4 molecule as a result of binding of the cell surface.
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens; D002417:Cattle / Q000276:immunology; D003165:Complement System Proteins; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005577:Forssman Antigen; D006168:Guinea Pigs; D006461:Hemolysis; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D011817:Rabbits / Q000276:immunology; D012710:Serum Albumin, Bovine
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D000939:Epitopes; D007106:Immune Sera; D012710:Serum Albumin, Bovine; D003165:Complement System Proteins; D005577:Forssman Antigen