New rapid method for diagnosis of deep venous thrombosis.
The plasma concentration of the platelet-specific protein beta-thromboglobulin was measured in fourteen patients who had been investigated for deep venous thrombosis by venography or 125I-fibrinogen scanning. All six patients with a proven thrombus had a raised plasma concentration of beta-thromboglobulin. Eight patients in whom no thrombus could be demonstrated had plasma concentrations of beta-thromboglobulin similar to a control group of thirty-five normal individuals. These results indicate that the measurement of plasma beta-thromboglobulin concentrations may be of use in the diagnosis of deep venous thrombosis.
D000328:Adult; D000368:Aged; D001609:Beta-Globulins / Q000032:analysis*; D005069:Evaluation Studies as Topic; D005260:Female; D005340:Fibrinogen; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008722:Methods; D008875:Middle Aged; D010690:Phlebography; D010974:Platelet Aggregation; D011863:Radioimmunoassay; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000097:blood / Q000175:diagnosis*; D013997:Time Factors
D001609:Beta-Globulins; D007457:Iodine Radioisotopes; D005340:Fibrinogen