title: Cross-neutralization between vesicular stomatitis virus type Indiana and Chandipura virus.
abstract: Using highly potent immune sheep sera, it was possible to demonstrate that: (1) Two rhabdoviruses, classified in the Vesiculovirus genus on morphological grounds but previously considered unrelated, viz., the vesicular stomatitis virus type Indiana (VSV), and Chandipura virus (ChV), show a low-level, but distinct cross-neutralization. This was, in most combinations, considerably increased by complement. (2) The species of cells used for growing the viruses for immunization and for neutralization tests, influenced the level of cross-neutralization. (3) No cross-reaction between VSV and ChV could be detected in the immunodiffusion reaction. (4) Immune sera, raised in sheep by immunization with the two purified rhabdoviruses contained complement-dependent cytotoxic antibodies specifically reacting with the cell species used for growing the viruses.
mesh_terms: D000956:Antigens, Viral / Q000032:analysis*; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D005779:Immunodiffusion; D009500:Neutralization Tests; D012209:Rhabdoviridae / Q000276:immunology*; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology*
chemical_list: D000956:Antigens, Viral