Immunological studies of subacute measles encephalitis in ferrets: similarities to human subacute sclerosing panencephalitis.
Ferrets inoculated with subacute sclerosing panencephalitis virus strains D.R. and Biken developed a subacute encephalitis. Brain extracts, at neutral pH, from these ferrets showed high measles antibody titers, increased concentrations of immunoglobulin G (IgG), and higher IgG/albumin ratios than those of controls. Although the brain extracts of subacute encephalitic animals showed significant synthesis of measles-specific IgG (20 to 60% of the total IgG) within the central nervous system, the electrophoretic patterns of these extracts did not show oligoclonal bands in the gamma-globulin region. Brain residues from most ferrets with subacute encephalitis, when eluted at low pH, demonstrated the presence of bound measles-specific antibodies. Excluding the electrophoresis data, other results are identical to those seen in human subacute sclerosing panencephalitis, indicating that the subacute encephalitis in ferrets may serve as a model for human subacute sclerosing panencephalitis.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D001921:Brain / Q000276:immunology; D004195:Disease Models, Animal; D005289:Ferrets; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008459:Measles virus / Q000276:immunology; D013190:SSPE Virus / Q000276:immunology*; D012709:Serum Albumin / Q000032:analysis; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D012709:Serum Albumin