title: [Separation of potassium and calcium channels in the nerve cell soma membrane].
abstract: Calcium inward and potassium outward currents were studied on internally dialysed isolated neurons of the snail Helix pomatia. Different sensitivity of the corresponding channels to changes in external pH was found. This difference was used for separation of their activation regions on the potential axis so that the characteristics of the inward and outward currents could be studied with minimal overlap. It is shown that the outward current channels possess a definite permeability to Tris ions (PTris :PK=0.05). This explains the impossibility to switch off this current by substituting Tris for internal potassium. The channels for the inward calcium current inactivate slowly with a first order kinetic; their instantaneous current-voltage characteristic reveals considerable Goldman-type rectification. The selectivity of the calcium channels to other bivallent cations is Ba:Sr:Ca:Mg=2.8:2.6:1.0:0.2.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006372:Helix, Snails / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007473:Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials; D009474:Neurons / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D014325:Tromethamine / Q000378:metabolism
chemical_list: D007473:Ion Channels; D013757:Tetraethylammonium Compounds; D014325:Tromethamine; D011188:Potassium; D002118:Calcium
vernacular_title: Razdelenie kalievykh i kal'tsievykh kanalov v membrane somy nervnoĭ kletki.