Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding.
Following unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.
D000818:Animals; D001058:Apomorphine / Q000378:metabolism*; D002090:Butyrophenones / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*; D013378:Substantia Nigra / Q000187:drug effects*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002090:Butyrophenones; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D013134:Spiperone; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine