Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602).
On account of the conflicting data concerning the action of 5-HTP on human sleep, repeated high doses were administered to three healthy subjects. The paradoxical sleep time and percentage tend to show a decrease during the 2nd week of treatment, followed by a rebound effect after the end of the treatment. In two subjects who initially had a small amount of slow wave sleep (SWS), the treatment induced an increase in SWS that persisted after the end of the treatment. Similar results were obtained after administration of 5-HTP together with RO.04.4602.
D006916:5-Hydroxytryptophan / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001545:Benserazide / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D004569:Electroencephalography; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D008606:Mental Processes / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*
D004338:Drug Combinations; D006834:Hydrazines; D001545:Benserazide; D006916:5-Hydroxytryptophan