[General characteristics and comparative evaluation of the radioprotective properties of aryl alkyl amine adrenomimetics in experiments on mice].
The radioprotective effect (RPE) of some arylalkylamines (AAAs) was studied in experiments on mice. Mesaton and its close analogues were injected subcutaneously 15 minutes prior to irradiation at a dose of 800 rad. The protective effect is exerted by AAAs in low doses (25--50 mumole/kg), the compounds show stable and high RPE (80--80% survival, dose reduction factor being 1.3--1.4) and low toxicity (LD50 = 4--8 mumole/kg). AAAs studied are not less effective than aminothiols. Their pharmacological spectrum--K = LD50/ED50 (200--500) is superior to that of known aminothiols and indolylalkylamines.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005039:Etilefrine / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009655:Octopamine / Q000633:toxicity; D010656:Phenylephrine / Q000633:toxicity; D011837:Radiation-Protective Agents; D013566:Sympathomimetics / Q000633:toxicity*; D000338:beta-Aminoethyl Isothiourea / Q000633:toxicity
D011837:Radiation-Protective Agents; D013566:Sympathomimetics; D009655:Octopamine; D000338:beta-Aminoethyl Isothiourea; D010656:Phenylephrine; D005039:Etilefrine
Obshchaia kharakteristika i sravnitel'naia otsenka radiozashchitnykh svoistv adrenomimetikov riada arilalkilaminov v opytakh na myshakh.