Etomidate, a new water-soluble non-barbiturate intravenous induction agent.
This paper describes clinical experimence, in 100 patients, with the new non-barbiturate, water soluble induction agent, etomidate. This drug produces sleep in one arm/brain circulation-time. There was no effect on pulse-rate, a slight fall in blood-pressure, and a low frequency of apnoea. Involuntary movements were noted, and in some patients these were severe. Etomidate warrants further evaluation as an intravenous induction agent.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001049:Apnea / Q000139:chemically induced; D001593:Benzyl Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced; D011674:Pulse / Q000187:drug effects; D012995:Solubility; D013997:Time Factors
D000777:Anesthetics; D001593:Benzyl Compounds; D007093:Imidazoles