[Immunological aspects in the L-asparaginase treatment of children with lymphoproliferative diseases].
A group of 20 children, including 14 with acute lymphoblastic leukemia and 6 with lymphosarcoma, was studied. 24 cures of l-asparaginase therapy were carried out. The increase of serum immunoglobulin (IgG, IgA, IgM) levels was found in children treated with smaller (from 300 to 500 I.U./kg b. w.) doses of asparaginase. In the group treated with higher doses (from 501 to 760 I.U./kg b. w.) the maximal increase of immunoglobulins was observed in the second half of the cure with l-asparaginase, followed by a decrease of the immunoglobulins levels at the end of treatment. The presence of anti-asparaginase antibodies in two children with anaphylactic shocks after l-asparaginase has been shown. In these two children and 6 others the lymphocyte count significantly dropped down on the day of shock before l-asparaginase injection.
D000293:Adolescent; D000707:Anaphylaxis / Q000276:immunology; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D001215:Asparaginase / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007958:Leukocyte Count; D008214:Lymphocytes; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use
D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D001215:Asparaginase; D011241:Prednisone
Immunologische Aspekte bei der L-Asparaginase-Behandlung von Kindern mit lymphoproliferativen Erkrankungen