Therapy of cluster headache with histamine H1 and H2 receptor antagonists.
Treatment with the histamine H2 receptor antagonist, cimetidine, alone and/or in combination with the histamine H1 receptor antagonist, chlorpyramine, in 13 patients showed that cimetidine alone was ineffective. 7 of 9 patients taking the combination of H1 and H2 receptor antagonists responded well to the treatment; in 1 patient, medication was ineffective and in 1 patient, success was doubtful. In 3 patients with chronic cluster headache, the effect faded after 4 weeks. The results are discussed.
D002927:Cimetidine / Q000627:therapeutic use*; D003027:Cluster Headache / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005029:Ethylenediamines / Q000627:therapeutic use*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011725:Pyridines / Q000627:therapeutic use; D014653:Vascular Headaches / Q000188:drug therapy*
D005029:Ethylenediamines; D006146:Guanidines; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D011725:Pyridines; C004664:chloropyramine; D002927:Cimetidine