[Adenylate cyclase and guanylate cyclase activity in the isolated kidney glomerulus of the rat].
Isolated rat renal glomeruli contain an adenylate cyclase system and guanylate cyclase system. Adenylate cyclase was strikingly activated by purified parathyroid hormone, epinephrine, prostaglandin I2 and histamine. The demonstration of PTH activated adenylate cyclase in glomeruli raises the possibility of a role of this hormone in regulation of glomerular filtration rate. Guanylate cyclase was strikingly activated by CA2+, nitrate derivatives such as sodium nitroprusside. Its role remained still unknown.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006162:Guanylate Cyclase / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000201:enzymology*; D051381:Rats
D001337:Autonomic Agents; D006728:Hormones; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase
Activité adénylate cyclasique et guanylate cyclasique du glomérule isolé de rein de rat.