title: [Focalized irrigation-lavage and sequential use of a new antiseptic by local and general route. Preliminary report apropos of 2 cases of suppurative pancreatic necrosis].
abstract: In view of the severe course seen in the presence of any suppurated pancreatic necrosis, it was felt to be of value to treat two patients by the adjuvant use of a new antiseptic tauroline, administered locally and, where appropriate, systemically. After surgical excision of pancreatic and peripancreatic necrotic tissue, the authors prefer to avoid active suction drainage of the residual pocket, replacing it by continuous and prolonged post-operative irrigation-lavage, together with the sequential, twice-daily use of a solution of 2 p. 100 tauroline. In view of the presence of a Gram negative septicemia (organisms identical to those of the suppurated area), the same substance was given by intravenous infusion in a 0.5 p. 100 solution, this being the only systemic, anti-infectious therapy. The effectiveness, good tolerance and originality of this new substance, active against Gram negative, Gram positive, aerobic and anaerobic organisms as well as yeast, have led the authors to immediately report their initial experience with its use.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009336:Necrosis; D010182:Pancreatic Diseases / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D013492:Suppuration; D013654:Taurine / Q000031:analogs & derivatives; D007507:Therapeutic Irrigation / Q000379:methods*; D013829:Thiadiazines / Q000008:administration & dosage*; D013843:Thiazines / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D013829:Thiadiazines; D013843:Thiazines; D013654:Taurine; C012566:taurolidine
vernacular_title: Irrigation-lavage focalisée et utilisation séquentielle d'un nouvel anti-septique par voies locale et générale. Note préliminaire à propos de deux cas de nécrose pancréatique suppurée.