title: Metabolic acidosis in patients receiving anticonvulsants.
abstract: Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.
mesh_terms: D000138:Acidosis / Q000139:chemically induced*; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D001639:Bicarbonates / Q000097:blood; D002118:Calcium / Q000097:blood; D002256:Carbonic Anhydrases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D006863:Hydrogen-Ion Concentration
chemical_list: D000927:Anticonvulsants; D001639:Bicarbonates; D000469:Alkaline Phosphatase; D002256:Carbonic Anhydrases; D002118:Calcium