[Late chronic dyskinesia from neuroleptic drugs (CSF and pharmacological data) (author's transl)].
CSF values of dopamine and serotonine metabolites (homovanillic acid and 5-hydroxy-indoleacetic acid) have been studied in 4 patients suffering from late dyskinesia due to neuroleptics. Trazodone (which acts on all monoaminergic systems, namely noradrenergic, dopaminergic and serotoninergic) induced a marked clinical improvement associated with CSF HVA increase and 5-HIAA decrease. The Authors suggest that involuntary movements could be due to an impairment of 5-HT e DA link.
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000134:cerebrospinal fluid / Q000188:drug therapy; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D012701:Serotonin / Q000378:metabolism; D014196:Trazodone / Q000627:therapeutic use*
D014150:Antipsychotic Agents; D010879:Piperazines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid; D014196:Trazodone
Discinesie croniche tardive da neurolettici. Dati farmacologici e liquorali.