Selective lesions of acinar pancreatic cells in rats poisoned with abrin. A morphological and biochemical study.
Rats poisoned with abrin (2.5 micrograms/100 g body weight) died within 36 h with severe necrosis of acinar pancreatic cells. Incorporation in vivo of labelled amino acids into pancreatic protein was greatly impaired 6 h after poisoning. Microsomes isolated from the pancreas of poisoned rats at 6 h had a reduced capacity for protein synthesis in vitro. Incorporation in vivo of orotic acid into pancreatic RNA was decreased 12 h after poisoning.
D000036:Abrin / Q000506:poisoning*; D000818:Animals; D003864:Depression, Chemical; D008297:Male; D008854:Microscopy, Electron; D008861:Microsomes / Q000648:ultrastructure; D009336:Necrosis; D009963:Orotic Acid / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D010940:Plant Proteins / Q000506:poisoning*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013997:Time Factors
D010940:Plant Proteins; D000036:Abrin; D009963:Orotic Acid; D012313:RNA