title: Neurotransmitter regulation of arginine vasotocin release from rat pineal glands in vitro.
abstract: Studies were performed to determine the effects of neurotransmitters on arginine vasotocin (AVT) release in vitro. Rat pineal glands were incubated with 10(-8)M or 10(-6)M norepinephrine (NE), dopamine (DA), serotonin (5HT), and acetylcholine (ACH) for eight h after which the concentrations of AVT in the media were determined by radioimmunoassay. With the exception of ACH, none of the neurotransmitters had a significant effect on AVT release. ACH significantly (P less than 0.05) elevated AVT release in vitro at the 10(-6)M concentration but not at the 10(-8)M concentration. The data indicate that ACH may play a role in the regulation of rat pineal gland secretion of AVT in vitro.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D018377:Neurotransmitter Agents; D001127:Arginine Vasopressin; D012701:Serotonin; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine