Enhanced mortality in offsprings of male mice treated with 5-azacytidine prior to mating. Morphological changes in testes.
5-Azacytidine administered to male mice prior to mating resulted in their decreased fertility and in the loss of offsprings at different periods of embryonic and postnatal development. The drug interfered with mature spermatozoa and spermatids; considerable distortion of cellular associations in seminiferous epithelium has been observed. The possible interaction of 5-azacytidine with the function and/or formation of microtubule protein is discussed.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005298:Fertility / Q000187:drug effects; D005313:Fetal Death / Q000139:chemically induced*; D005327:Fetal Resorption / Q000139:chemically induced*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011247:Pregnancy; D012725:Sexual Behavior; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
D001374:Azacitidine