Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs.
The antiarrhythmic effects of dl'propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied. It was found that contrary to earlier findings in the dog, the effects of the adrenergic beta-blockers against ouabain-arrhythmias in guinea pigs were due to beta-blocking activity and not the membrane-stabilizing activity of the compounds. The cardioselective beta-blocker, metoprolol, was more or equally effective as dl-propranolol against ouabain-induced arrhythmias in guinea pigs.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D006168:Guinea Pigs; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D010042:Ouabain; D011433:Propranolol / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D010042:Ouabain; D008012:Lidocaine; D011433:Propranolol; D008790:Metoprolol