Terminal transferase in human bone-marrow lymphocytes.
Activity of the enzyme terminal transferase (TdT) has been localised in normal human bone-marrow lymphocytes. These cells may represent a prothymocyte population, which, on malignant transformation, may give rise to acute lymphoblastic leukaemia, and to some cases of chronic granulocytic leukaemia in the blastic phase.
D001853:Bone Marrow / Q000201:enzymology* / Q000473:pathology; D001854:Bone Marrow Cells; D002452:Cell Count; D002454:Cell Differentiation; D004254:DNA Nucleotidyltransferases / Q000502:physiology*; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology; D007951:Leukemia, Myeloid / Q000209:etiology; D008214:Lymphocytes / Q000201:enzymology* / Q000473:pathology
D004254:DNA Nucleotidyltransferases