Use of co-trimoxazole in chronic renal failure.
Twenty patients with chronic renal failure and either urinary or respiratory tract infection were treated with co-trimoxazole. Seventeen patients showed no deterioration in renal function while receiving co-trimoxazole. Deterioration in renal function during treatment in the other three patients was due to factors other than administration of the drug. It is concluded that co-trimoxazole can be used in patients with chronic renal failure provided the dose is adjusted according to the degree of renal failure.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011446:Prospective Studies; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*; D014508:Urea / Q000097:blood
D004338:Drug Combinations; D013607:Tablets; D014508:Urea; D014295:Trimethoprim; D003404:Creatinine; D013420:Sulfamethoxazole