title: Altered activation of tyrosine hydroxylation by gamma-butyrolactone following chronic ethanol treatment.
abstract: The results from the present study support the contention that chronic ethanol administration alters the activity of central dopamine neurons. Chronic ethanol administration was shown to disrupt normally occurring feedback mechanisms involved in the regulation of tyrosine hydroxylation.
mesh_terms: D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000096:biosynthesis; D000431:Ethanol / Q000494:pharmacology*; D005246:Feedback; D005663:Furans / Q000494:pharmacology*; D006900:Hydroxylation; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
chemical_list: D005663:Furans; D011954:Receptors, Dopamine; D000431:Ethanol; D004295:Dihydroxyphenylalanine; D014446:Tyrosine 3-Monooxygenase; D015107:4-Butyrolactone