[The effect of heparin and a human heparin precipitable plasma fraction on antibody producing cells in vitro].
A study was made of the effect of heparin and heparin-precipitable fractions of human blood plasms (HPF) on the capacity of the cells of mouse spleen immunized with sheep erythrocytes to plaque-formation in vitro. It was found that heparin and HPF produced an inhibitory effect on the reaction of plaque formation as a result of interaction with lymphocytes. It is supposed that a possible point of application of heparin and HPF action are surface cell membranes of the antibody-forming cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D003864:Depression, Chemical; D005260:Female; D006462:Hemolytic Plaque Technique; D006493:Heparin / Q000494:pharmacology*; D007106:Immune Sera / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D051381:Rats; D013154:Spleen / Q000276:immunology*; D005719:gamma-Globulins / Q000494:pharmacology
D007106:Immune Sera; D005719:gamma-Globulins; D006493:Heparin
Deĭstvie geparina i geparinosazhdaemoĭ fraktsii plazmy krovi cheloveka na antiteloprodutsiruiushchie kletki in vitro