[Disordered regulation of cell membrane adenyl cyclase and guanyl cyclase activity as a possible factor in carcinogenesis].
The author suggests an interpretation of the recently recognized significant enzymatic imbalance in cancer cell as a result of the shift in the balance of cell memrane adenyl- and guanylcyclase activities in favour of the former. The alternative patterns of the development of hypothetical central and peripheral regulatory disturbances are dealt with. The prospective new therapeutic approaches offered by the pathomechanism under study are pointed out.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP
Narushennaia reguliatsiia aktivnosti adeniltsiklazy i guaniltsiklazy kletochnoĭ membrany kak vozmozhnyĭ faktor v kantserogeneze.