Effect of catecholamines and beta-blockers on linoleic acid desaturation activity.
The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 microgram/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through beta receptors by an enhancement of the intracellular levels of cyclic AMP.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D044943:Fatty Acid Desaturases / Q000037:antagonists & inhibitors; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008041:Linoleic Acids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D000319:Adrenergic beta-Antagonists; D008041:Linoleic Acids; D011433:Propranolol; D044943:Fatty Acid Desaturases; D007545:Isoproterenol; D004837:Epinephrine