title: Genetic marker for insulin-dependent diabetes mellitus.
abstract: A rare genetic type (Bf F1) of properdin factor B is found in 22.6% of patients with insulin-dependent diabetes mellitus but in only 1.9% of the general population, yielding a relative risk of 15.0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.
mesh_terms: D000328:Adult; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D011415:Complement Factor B / Q000235:genetics*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000235:genetics* / Q000635:transmission; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D004200:Diseases in Twins; D004792:Enzyme Precursors / Q000235:genetics*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D014430:Twins, Monozygotic
chemical_list: D004792:Enzyme Precursors; D007328:Insulin; D011415:Complement Factor B