Oncornavirus: isolation from a squirrel monkey (Saimiri sciureus) lung culture.
An oncornavirus isolated from a squirrel monkey (Saimiri sciureus) lung culture has a density of 1.16 to 1.17 grams per milliliter, contains 70S RNA, and has an RNA-directed DNA polymerase that prefers Mg2+ over Mn2+ in an assay in which polyribocytidylate - oligodeoxyguanylate (12-18) is used as a synthetic template. Morphologically, the virus resembles Mason-Pfizer monkey virus but is antigenically distinct from this virus. The virus grows in cells of human, chimpanzee, rhesus monkey, canine, and mink origin, but not cells of squirrel monkey origin. On the basis of its properties, the newly isolated virus can be classified as a retravirus.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D003429:Cross Reactions; D004789:Enzyme Activation; D000882:Haplorhini / Q000382:microbiology*; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008168:Lung / Q000382:microbiology*; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009858:Oncogenic Viruses / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology; D012367:RNA, Viral / Q000032:analysis; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012453:Saimiri / Q000382:microbiology*; D013698:Templates, Genetic
D000956:Antigens, Viral; D012367:RNA, Viral; D008345:Manganese; D012194:RNA-Directed DNA Polymerase; D008274:Magnesium