Filtrability of erythrocytes in "hypersplenic" rats.
The values of haemoglobin, reticulocytes and half-times of the filtrability of non-washed and washed erythrocytes were examined in male albino rats, Wistar strain, after i.p. injections of methylcellulose (MC) and compared with controls. In individual experiments the rats received 2 to 32 injections of MC. In injected animals, the filtrability of non-washed erythrocytes was altered. The filtrability half-times of the washed erythrocytes did not differ from the controls. Thus, the filtrability is altered for extracorpuscular reasons. "Hypersplenism" being completely developed, (after 32 MC injections), the filtrability of non-washed erythrocytes repaired when the application of MC had been discontinued, the reticulocyte values remained however increased. Problems of the mechanism of anaemia in experimental "hypersplenism" after MC injections in rats and relations between the altered filtrability of the erythrocytes and the haemolysis are discussed.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects*; D005374:Filtration; D006971:Hypersplenism / Q000097:blood* / Q000139:chemically induced; D008297:Male; D008747:Methylcellulose / Q000494:pharmacology*; D051381:Rats
D008747:Methylcellulose