Factor VIII-related antigen (VIII R:AG) in haemophilic patients and in carriers.
All of fourteen patients with severe classic haemophilia and twelve of fifteen obligate carriers had a pre-peak ("rocket") above the sample well when factor VIII-related antigen was examined by crossed immunoelectrophoresis. The pre-peak may be found in other conditions--including von Willebrand's disease--but if these conditions can be excluded, the pre-peak may be helpful in identification of carriers or haemophilia.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006580:Genetic Carrier Screening; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007223:Infant; D008297:Male; D008875:Middle Aged; D014842:von Willebrand Diseases / Q000276:immunology
D000941:Antigens; D005169:Factor VIII