title: [Carcinine (beta-alanyl-histamine): rapid synthesis and action on vertebrate blood pressure].
abstract: 1.-- Synthesis of carcinine was performed by direct condensation of beta-alanine with histamine (free base), in the presence of N-N'-dicyclocarbodiimide. The amine radical of beta-alanine was protected by the t-butoxycarbonyl radical. This fast and simple method yielded a perfectly pure crystalline product. 2.-- Carcinine had no influence upon heartbeat frequency nor on respiratory movements in rats. 3. -- Carcinine had a vasodepressive action upon Vertebrates. It was active at half the concentration of carnosine and at about a thousand times the concentration of histamine. It appeared that histamine lost a great extent of its activity when linked with beta-alanine.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002336:Carnosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D004024:Dicyclohexylcarbodiimide; D004151:Dipeptides / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D004151:Dipeptides; D004024:Dicyclohexylcarbodiimide; D002336:Carnosine; C015055:carcinine
vernacular_title: La carcinine (beta-alanyl-histamine): synthèse rapide, action sur la pression sanguine des vertébrés.