[beta2-Microglobulin and experimental nephropathies in macacus monkey (author's transl)].
In the monkey, the action of four renal toxics : lead acetate, sodium maleate, cadmium chloride and sodium chromate was compared. Tubulopathies were obtained only with cadmium chloride and sodium chromate with in the best cases about 16 mg/l of beta2-microglobulin (beta2m) in the urine. Monkey and human beta2m have the same molecular weight and are antigenically similar. However, they differed in electrophoretic mobility, the monkey beta2m being slightly more cathodic.
D000818:Animals; D001609:Beta-Globulins / Q000652:urine*; D002104:Cadmium / Q000009:adverse effects; D002840:Chromates / Q000009:adverse effects; D004195:Disease Models, Animal; D000882:Haplorhini; D007674:Kidney Diseases / Q000652:urine*; D007684:Kidney Tubules / Q000187:drug effects; D007854:Lead / Q000009:adverse effects; D008251:Macaca; D008298:Maleates / Q000009:adverse effects; D008970:Molecular Weight; D011507:Proteinuria / Q000652:urine; D012964:Sodium / Q000009:adverse effects; D001613:beta 2-Microglobulin / Q000652:urine*
D001609:Beta-Globulins; D002840:Chromates; D008298:Maleates; D001613:beta 2-Microglobulin; D002104:Cadmium; D007854:Lead; D012964:Sodium
Néphropathies expérimentales et beta2-microglobuline chez le singe.