title: Propranolol as an adjunct to the treatment of schizophrenia.
abstract: Propranolol contributed usefully to the practical management of patients with chronic schizophrenia whose florid symptoms had not remitted with major tranquillisers. 14 patients who had received an average equivalent of 954 mg per day of chlorpromazine for 10 years were given, in addition, either propranolol or a placebo for 12 weeks. Both groups had improved by the twelfth week, but the propranolol group had improved significantly more.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects; D012075:Remission, Spontaneous; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D010919:Placebos; D011433:Propranolol; D002746:Chlorpromazine