The effect of bleomycin on rat bone marrow cells.
Experiments were carried out to determine the cytogenetic effects of the antibiotic bleomycin (BLM) in rats using the bone marrow system. A total of eighteen male and eighteen female Sprague-Dawley rats were injected with varying concentration of BLM, over varying periods of time. The results revealed that at low concentrations BLM showed no alteration in the ploidy or the morphology of rat chromosomes. This however, was not the case when the dose or administration period was increased.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011003:Ploidies; D051381:Rats; D013997:Time Factors
D001761:Bleomycin