title: Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment.
abstract: Replication times for all important chromosome bands, of both types R and Q (277 structures) are analysed. The R-bands form a group of structures whose DNA replicates during the early S-phase, while the DNA situated in the Q-bands replicates during the late S-phase. There may not exist overlapping between replication times of these two types of structures. The widest R-bands are those which are the earliest to replicate; in general, the most intense Q-bands are those which are the latest to replicate. Especially among these last ones, a certain asynchronism exists between the replication times. Finally the heterochromatin of chromosomes 1, 16 and Y and of the short arms of the acrocentrics could contain two types of DNA which replicate at different times.
mesh_terms: D001973:Bromodeoxyuridine; D002875:Chromosomes / Q000378:metabolism*; D004261:DNA Replication; D006570:Heterochromatin / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D011796:Quinacrine; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D006570:Heterochromatin; D001973:Bromodeoxyuridine; D011796:Quinacrine