Nocturnal ulcer pain associated with slow-wave sleep.
It is suggested that the early-morning growth-hormone release associated with slow-wave sleep is due to inhibition of somatostatin secretion from the hypothalamus. It is also associated with inhibition of gastrointestinal somatostatin, causing a release of gastrin and insulin. Because the levels of glucocorticoid hormones are concurrently low, the insulin effect is unopposed and increases gut motility through augmented vagal tone. This results in an increased delivery of acid to the duodenum. In duodenal-ulcer patients, whose duodenal buffering capacity is reduced because of a relative deficiency of secretin response, this leads to pain.
D000818:Animals; D002415:Cats; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000503:physiopathology*; D004386:Duodenum / Q000503:physiopathology; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology; D000078790:Insulin Secretion; D010146:Pain / Q000209:etiology*; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D012890:Sleep / Q000502:physiology*; D013004:Somatostatin / Q000172:deficiency / Q000378:metabolism
D005755:Gastrins; D007328:Insulin; D013004:Somatostatin; D013006:Growth Hormone