Infertility in male pesticide workers.
A number of cases of infertility were discovered among men working in a California pesticide factory. The suspected cause was exposure to the chemical 1,2-dibromo-3-chloropropane (D.B.C.P.). The major effects, seen in 14 of 25 non-vasectomised men, were azoospermia or oligospermia and raised serum-levels of follicle-stimulating hormone and luteinising hormone. No other major abnormalities were detected, and testosterone levels were normal. Although a quantitative estimation of exposure could not be obtained, the observed effects appeared to be related to duration of exposure to D.B.C.P.
D000328:Adult; D000969:Antinematodal Agents / Q000009:adverse effects*; D002140:California; D002452:Cell Count; D002617:Chemical Industry; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000009:adverse effects*; D007248:Infertility, Male / Q000139:chemically induced* / Q000175:diagnosis; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D009845:Oligospermia / Q000139:chemically induced / Q000473:pathology; D011407:Propane / Q000009:adverse effects / Q000031:analogs & derivatives*; D013094:Spermatozoa / Q000473:pathology; D013739:Testosterone / Q000097:blood
D000969:Antinematodal Agents; D006846:Hydrocarbons, Halogenated; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C007318:1,2-dibromo-3-chloropropane; D011407:Propane