Substrate requirements in vitro for the spontaneous motility of uterine strips from ovariectomized or natural estrus rats. Relationships with tissue levels of glycogen and triglycerides.
The influence of metabolic substrates (glucose, fructose, lactate, pyruvate) on the spontaneous motility of uterine strips isolated from estrus or spayed rats was explored. The effects of substrate omission on tissue glycogen and triglycerides in both hormonal conditions were also studied. The results indicate an important role of glycolysis for rat uterine motility. It would appear also that the better contractile performance of strips from ovariectomized animals might be related to their capacity to metabolize readily triglyceride energy stores.
D000818:Animals; D002369:Castration; D004971:Estrus; D005260:Female; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism*; D006019:Glycolysis; D066298:In Vitro Techniques; D007773:Lactates / Q000494:pharmacology; D011247:Pregnancy; D011773:Pyruvates / Q000494:pharmacology; D051381:Rats; D014280:Triglycerides / Q000378:metabolism*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000378:metabolism*
D007773:Lactates; D011773:Pyruvates; D014280:Triglycerides; D005632:Fructose; D006003:Glycogen; D005947:Glucose