Ly and Ia phenotype of suppressor T cells induced by graft-vs.-host reaction.
Suppressor T cells were generated in (CBA X C57BL)F1 mice undergoing graft-vs.-host (GvH) reaction and treated with anti-Ly and anti-Ia antisera to determine their membrane antigen phenotype. Pretreatment of CBA-induced GvH suppressor T cells with anti-Ly-1.1, anti-Ly-2.1 or anti-Iak antisera plus complement abrogated their suppressive properties when tested against primed F1 spleen cells in vitro. In contrast, concanavalin A (Con A)-induced suppressor T cells were insensitive to anti-Ly-1.1 serum. It is concluded that GvH-induced suppressor T cells are Ly-1+,2+,3+,Ia+, and thus distinct from Con A or antigen-induced suppressor T cells.
D000818:Animals; D000941:Antigens; D000961:Antilymphocyte Serum / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D000939:Epitopes; D005260:Female; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000961:Antilymphocyte Serum; D000939:Epitopes; D003208:Concanavalin A