[Characteristics of the cardiotropic effect of gutimine].
Experiments proved gutimine capable of intensify the collateral coronary circulation, intraventricular pressure and the rate of its accretion (dp/dt), the excitability and permeability of the heart, as well as to raise the cardiac contractility in dogs during an acute period of myocardial ischemia. In rats with pituitrin-isadrine induced cardiopathy the drug drastically depressed the permeability of the histohematogenous barriers of the myocardium and lengthened somewhat the life span of the animals. Parallel with is rising doses gutimine depressed the excitability threshold of the frog's heart "in situ" in a test with a liminal current producing extrasystole.
D000578:Amidines / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001001:Anura; D003097:Collateral Circulation / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy*; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D009200:Myocardial Contraction / Q000187:drug effects; D010909:Pituitary Hormones, Posterior / Q000037:antagonists & inhibitors; D051381:Rats; D013268:Stimulation, Chemical; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000578:Amidines; D010909:Pituitary Hormones, Posterior; D013890:Thiourea; D007545:Isoproterenol
K kharakteristike kardiotropnogo deĭstviia gutimina