title: Malignant acanthosis nigricans--a para-endocrine syndrome?
abstract: A case is reported of acanthosis nigricans associated with a gastric carcinoma. The gastric cancer was of the diffuse, infiltrating type. Many tumour cells were identified by means of histochemistry and electron microscopy as neoplastic enterochromaffin-like cells. It is suggested that cancers associated with acanthosis nigricans might constitute a certain group of carcinomas in which parts of the tumour cells arise from the APUD-series of endocrine cells.
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology