title: Myoclonus developing after vermisectomy in photosensitive Papio papio.
abstract: Two vermisectomized photosensitive baboons exhibited two different types of myoclonus, one induced by intermittent light stimulation (ILS) and the other occuring "spontaneously". The characteristics of these two types of myoclonus are described from a clinical and from an ECoG point of view. Myoclonus induced by ILS (ML) started at the eyelids and secondarily invaded the face and body; it was always preceded by frontorolandic spike-waves or polyspike-waves. The "spontaneous" myoclonus which followed vermisectomy (MV) was "massive", but involved firstly the trunk and secondarily the face and limbs; no ECoG paraoxysm accompanied this myoclonus, but we observed a parietal evoked potential of small amplitude, 10--15 msec after its onset. If MLs can be considered as consequences of the fronto-rolandic paroxysmal discharges, MVs seem to originate in the brain stem but appear similar to action myoclonus. This experimental situation showing two types of myoclonus resembles human hereditary degenerative syndromes (dyssynergic cerebellar myoclonus, progressive myoclonic epilepsy), without being exactly comparable. The conditions in which MVs were seen and their modifications during sleep and by different drugs are described. The relationships between MVs and MLs and myoclonic epilepsy are discussed.
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000601:surgery*; D003975:Diazepam / Q000494:pharmacology; D004195:Disease Models, Animal; D004569:Electroencephalography; D000882:Haplorhini; D007649:Ketamine / Q000494:pharmacology; D008027:Light; D009207:Myoclonus / Q000209:etiology* / Q000503:physiopathology; D010215:Papio; D010775:Photic Stimulation
chemical_list: D007649:Ketamine; D003975:Diazepam