Cell-mediated immunity in pregnant women.
Phytohemagglutinin-induced lymphocyte transformation (PHA-T) was depressed in pregnant women, as compared with that in nonpregnant women. Pregnancy serum had a suppressive action on PHA-T which was enhanced with the advance in pregnancy. Hydrocortisone, progesterone, alpha-fetoprotein and trophoblast-specific antigen, were demonstrated as immune suppressive factors. From these results, it was concluded that cell-mediated immunity might be reduced in pregnant women and that this reduction might be one of the causes for the maintenance of pregnancy.
D000941:Antigens; D006063:Chorionic Gonadotropin / Q000097:blood / Q000494:pharmacology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011374:Progesterone / Q000097:blood / Q000494:pharmacology; D014327:Trophoblasts / Q000276:immunology; D000509:alpha-Fetoproteins / Q000032:analysis
D000941:Antigens; D006063:Chorionic Gonadotropin; D037102:Lectins; D000509:alpha-Fetoproteins; D011374:Progesterone; D006854:Hydrocortisone