Hematoporphyrin-sensitized photodynamic inactivation of viral RNA-dependent DNA polymerase.
Visible light (6328A) was shown to inactivate RNA-dependent DNA polymerase activity of Moloney mouse leukemia virus, in the presence of hematoporphyrin. The same treatment on exogenous, template-initiation complex had no effect on enzyme activity. It was suggested that this enzyme may be the target of photodynamic inactivation of this and related viruses.
D006415:Hematoporphyrins / Q000494:pharmacology*; D007834:Lasers; D008027:Light; D008979:Moloney murine leukemia virus / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors
D006415:Hematoporphyrins; D012194:RNA-Directed DNA Polymerase