Aldosterone in myxoedema.
Ten patients with severe myxoedema were treated with regular increments of thyroxine. The urine aldosterone excretion rate and plasma-aldosterone level increased with each increasing dose of thyroxine. Two patients in whom the serum-aldosterone rose to abnormally high levels had cardiac failure which resolved when the thyroxine dose was reduced.
D000450:Aldosterone / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D006929:Hyperaldosteronism / Q000139:chemically induced; D009230:Myxedema / Q000188:drug therapy* / Q000378:metabolism; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity
D000450:Aldosterone; D013974:Thyroxine