[Effect of long-term cytostatic therapy on the hematopoietic stem cells].
CFU-C and diffusion chamber studies were performed in patients with teratocarcinoma, who underwent long term chemotherapy. No significant decline of bone marrow CFU-C or diffusion chamber cell recovery was found during twelve months of cytotoxic treatment. In contrast to the results in these patients the CFU-C-content of the remission marrow in leukemic patients showed a significant decrease in relation to the duration of remission and chemotherapy.
D001761:Bleomycin / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D003114:Colony-Forming Units Assay; D004317:Doxorubicin / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D013724:Teratoma / Q000188:drug therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000627:therapeutic use
D001761:Bleomycin; D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin
Einfluss von zytostatischer Langzeitchemotherapie auf hämatopoetische Stammzellen.