Experiments for producing specific immunological tolerance by intrauterinely administered immunocompetent human cells.
As a consequence of living human leukocytes administered intrauterinely on the 16th day of pregnancy, it was not possible to study the litter since it fell victim to cannibalism immediately after delivery. After the administration of sonically disintegrate leukocyte antigen healthy newborns were dropped. Living human leukocytes administered before the age of 2 day to mice treated in this way, produced no GVH reaction ascertainable with loss of weight but a considerable number of deaths occurred in comparison to the control. Further possibilities of studying the anti-human anti-thymocyte serum by means of cell chimeras are discussed.
D000818:Animals; D001835:Body Weight; D000939:Epitopes; D005260:Female; D006087:Graft vs Host Reaction; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007267:Injections; D007962:Leukocytes / Q000276:immunology*; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D014599:Uterus
D000939:Epitopes