Prostacyclin overproduction in Bartter's syndrome.
Urinary excretion of 6-keto-prostaglandin F1alpha and thromboxane B2, the major metabolites of prostacyclin and of thromboxane A2, respectively, was measured by specific radioimmunoassays in five female patients with Bartter's syndrome and in five normal female controls. The patients with Bartter's syndrome excreted about four times as much 6-keto-PGF1alpha as the controls; their excretion of thromboxane B2 was no different from that of the controls. These data suggest that overproduction of prostacyclin mediates both the hyper-reninaemia and the hyporesponsiveness of blood-pressure to pressor agents in Bartter's syndrome.
D000293:Adolescent; D000328:Adult; D001095:Arachidonic Acids / Q000378:metabolism; D001477:Bartter Syndrome / Q000503:physiopathology*; D001794:Blood Pressure; D002648:Child; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000503:physiopathology*; D007651:Keto Acids / Q000652:urine; D008875:Middle Aged; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000652:urine; D011460:Prostaglandins F / Q000652:urine; D011863:Radioimmunoassay / Q000379:methods; D012083:Renin / Q000097:blood; D013929:Thromboxane B2 / Q000652:urine; D014662:Vasoconstrictor Agents
D001095:Arachidonic Acids; D007651:Keto Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D014662:Vasoconstrictor Agents; D013929:Thromboxane B2; D011464:Epoprostenol; D012083:Renin