Effects of toyocamycin on the biological activity of a murine oncornavirus produced by a chronically infected cell line.
Production of Friend virus by chronically infected cells (Friend-Eveline cell line) is depressed by Toyocamycin, an adenosine analogue, at doses which stop cellular growth. The infectivity and the endogenous reverse transcriptase activity of the virions are diminished. These effects are likely to be due to the incorporation of Toyocamycin into the 70S RNA.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005622:Friend murine leukemia virus / Q000187:drug effects* / Q000472:pathogenicity; D051379:Mice; D012367:RNA, Viral / Q000378:metabolism; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D014127:Toyocamycin / Q000494:pharmacology*; D014771:Virion / Q000201:enzymology / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase; D014127:Toyocamycin