[Effect of S-adenosyl-L-methionine on the cerebral and peripheral metabolism of L-dopa].
The repartition of [3H]L-dopa administered i.p. does not change in rats treated with S-adenosyl-L-methionine (SAM). The effect was studied on the central nervous system and at the periphery. The biosynthesis of metabolites [3H]dopamine and [3H]3-O-methyldopamine are also unchanged. On the other hand, in the kidney an accumulation of [3H]norepinephrine +[3H]normetanephrine was observed, while in the brainstem + midbrain the synthesis of these metabolites was decreased after SAM injection. The relations between these biochemical results and the pharmacological antiparkinsonian effects are discussed.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D007980:Levodopa / Q000378:metabolism*; D008297:Male; D008750:Methyldopa / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009647:Normetanephrine / Q000378:metabolism; D051381:Rats; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D014018:Tissue Distribution
D002395:Catecholamines; D009647:Normetanephrine; D007980:Levodopa; D008750:Methyldopa; D012436:S-Adenosylmethionine; D004298:Dopamine; D009638:Norepinephrine
Effet de la S-adénosyl-L-méthionine sur le métabolisme cérébral et périphérique de la L-dopa.