Further studies on the mode of action of Clostridium welchii type-D epsilon toxin.
Intradermal injection of Clostridium welchii type-D epsilon toxin increased the permeability of blood vessels in guinea-pig skin to Evans blue dye by a mechanism not dependent on the release of histamine. The toxin was also found to raise the plasma concentration of cyclic adenosine 3', 5'-monophosphate in mice. It is concluded that epsilon toxin is an enterotoxin capable of causing widespread damage, after binding to receptor sites on the surface of certain cells, through a mechanism mediated by an adenyl cyclase-cAMP system.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D003016:Clostridium perfringens; D000242:Cyclic AMP / Q000097:blood*; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D051379:Mice; D011738:Pyrilamine / Q000494:pharmacology
D001427:Bacterial Toxins; D000242:Cyclic AMP; D011738:Pyrilamine