title: Dynamics of the interaction between Entamoeba histolytica and components of the immune response. I. Capping and endocytosis; influence of inhibiting and accelerating factors; variation of the expression of surface antigens.
abstract: The possible implications of cell membrane dynamics in the host--parasite relationship has been studied. Entamoeba histolytica rapidly redistributed and internalized antibodies and Con A bound to its surface. The process was dependent on temperature, cell metabolism and changes of pH in the environment. Phagocytizing amoebae displayed a higher rate of membrane perturbations, which were similarly affected by temperature, cell metabolism and pH variations. Cytochalasin B partially inhibited the redistribution whereas colchicine did not. Colchicine in combination with Cytochalasin B augmented the inhibitory effect of Cytochalasin B alone. The expression of antigens at the surface of the amoeba showed cyclic fluctuations during cell growth.
mesh_terms: D000941:Antigens; D002462:Cell Membrane / Q000276:immunology*; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D003208:Concanavalin A / Q000276:immunology; D003571:Cytochalasin B / Q000494:pharmacology; D004705:Endocytosis; D004748:Entamoeba histolytica / Q000276:immunology*; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera; D007152:Immunologic Capping; D013696:Temperature
chemical_list: D000941:Antigens; D000939:Epitopes; D007106:Immune Sera; D003208:Concanavalin A; D003571:Cytochalasin B; D003078:Colchicine