Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning.
In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.
D000818:Animals; D001646:Bile / Q000378:metabolism; D007631:Chlordecone / Q000378:metabolism / Q000506:poisoning*; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D005243:Feces / Q000378:metabolism; D008658:Inactivation, Metabolic; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D051381:Rats; D014018:Tissue Distribution
D007306:Insecticides; D002792:Cholestyramine Resin; D007631:Chlordecone