Contraceptive steroid toxicology in the Beagle dog and its relevance to human carcinogenicity.
Problems associated with the use of the Beagle dog in chronic toxicological studies of contraceptive steroids are described. A short review is presented on the occurrence of spontaneous tumours in dogs and in bitches of various breeds. The current status of knowledge of canine reproductive hormones and endocrinology is outlined, together with effects of contraceptive steroids. The pathology and histological classification of spontaneous and induced mammary neoplasia in the dog is discussed and compared with breast cancer in women. A series of recommendations are included for future research in this field which it is hoped may resolve some of the outstanding issues and lead to a more suitable toxicological model for contraceptive steroids.
D000818:Animals; D001943:Breast Neoplasms; D002415:Cats; D002715:Chlormadinone Acetate / Q000633:toxicity; D003271:Contraceptive Agents, Female / Q000633:toxicity*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000453:epidemiology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004967:Estrogens / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000032:analysis; D006801:Humans; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D008535:Megestrol / Q000633:toxicity; D009369:Neoplasms / Q000662:veterinary; D011374:Progesterone / Q000097:blood / Q000633:toxicity; D013552:Swine
D003271:Contraceptive Agents, Female; D004967:Estrogens; D006065:Gonadotropins, Pituitary; D002715:Chlormadinone Acetate; D011374:Progesterone; D008535:Megestrol