Effect of magnitude of daily continuous radiation dose on serum proteins and survival in rats.
Changes in serum prealbumin, A1-macroglobulin, transferrin, and complement levels were studied in rats irradiated with daily doses of 100R (0.0258 C/kg), 200R (0.0516 C/kg) and 400R (0.1032 C/kg) until death. The daily dose of 100R applied for 39 days produced no changes in prealbumin and transferrin and a rise in the levels of A1-macroglobulin and complement. Shortly before death, i.e., between 39 and 44 days of irradiation, the levels of all four patients dropped. Daily doses of 200 and 400R caused a reduction in the levels of all four proteins since the very beginning. The LD 50 was 4 270R (1.1017 C/kg) at 100R/day, 4 060 R (1.0475 C/kg) at 200R/day, and 4 520 R (1.1342 C/kg) at 400R/day.
D000818:Animals; D001798:Blood Proteins / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects*; D003165:Complement System Proteins / Q000528:radiation effects; D008297:Male; D011228:Prealbumin / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D014168:Transferrin / Q000528:radiation effects; D000511:alpha-Macroglobulins / Q000528:radiation effects
D001798:Blood Proteins; D011228:Prealbumin; D014168:Transferrin; D000511:alpha-Macroglobulins; D003165:Complement System Proteins