Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells.
Monosialoganglioside liposomes are rapidly taken up by the liver as compared to dicetylphosphate, phosphatidic acid or neutral liposomes. Asialoganglioside GM 1 liposomes are taken up with the same avidity as ganglioside GM 1 liposomes. Competition experiments with asialofetuin suggest that this uptake is mediated by specific recognition of the terminal galactose residues of the glyco-lipid liposomes by the receptor present on the plasma membrane of the parenchymal cells of liver. Thus liposomes containing glycolipids with terminal beta-galactosyl residues should provide an approach for specifically directing biologically active molecules to liver parenchymal cells.
D000818:Animals; D005732:Gangliosides / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008081:Liposomes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats; D012794:Sialic Acids; D013393:Sucrase / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000378:metabolism
D005732:Gangliosides; D008081:Liposomes; D012794:Sialic Acids; D000509:alpha-Fetoproteins; D013393:Sucrase