Cytotoxic effect of anti-H-2 and anti-Ia antisera on human B and T cells.
Anti-H-2 and anti-Ia alloimmune mouse antisera were tested by the microcytotoxicity test on human peripheral blood B- and T-cell preparations. Anti-H-2 antisera react by a higher titer and/or cytotoxicity scoring grade on B cels than on T cells. Anti-Ia antisera react practically only with B cells. It was assumed that anti-H-2 antisera contain two components. One component reacts specifically with certain HLA-A- or -B-locus antigens or other closley linked gene products. The other component reacts predominantly or only with B-cell determinants; the specificity of the latter component has not yet been studied in sufficient detail.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007519:Isoantigens; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D007106:Immune Sera; D007519:Isoantigens