Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction induced by secretin, cholecystokinin-pancreozymin and carbachol administration.
The effect of somatostatin on secretin-, CCK-pancreozymin-and-carbachol-stimulated pancreatic secretion was studied in eight healthy volunteers. In all instances there was a significant reduction in duodenal secretory volume after secretin without any change in bicarbonate concentration. CCK-parcreozymin and carbachol stimulated volume and enzyme secretion were significantly inhibited and gallbladder contraction was abolished by somatostatin. In three volunteers a reversible hypercoagulation during infusion of 200 mug/h cyclic somatostatin has been observed. Somatostatin inhibited the CCK-pancreozymin stimulated pancreatic enzyme secretion of anaesthesized rats.
D000681:Amylases / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D002217:Carbachol / Q000008:administration & dosage*; D002766:Cholecystokinin / Q000008:administration & dosage; D005704:Gallbladder / Q000187:drug effects*; D005768:Gastrointestinal Hormones / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010179:Pancreas / Q000187:drug effects*; D010189:Pancreatic Juice / Q000201:enzymology / Q000378:metabolism*; D012633:Secretin / Q000008:administration & dosage; D013004:Somatostatin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014357:Trypsin / Q000378:metabolism
D005768:Gastrointestinal Hormones; D012633:Secretin; D013004:Somatostatin; D002217:Carbachol; D002766:Cholecystokinin; D000681:Amylases; D014357:Trypsin; D001663:Bilirubin