[Experiences with the electrophoretic mobility test in children. A diagnostic help in pediatric oncology? (author's transl)].
Lymphocyte sensitisation to encephalitogenic factor (EF) was determined in 131 children with the electrophoretic mobility test (EM-test) to find out, whether this test may be helpful in the diagnosis of malignant disease in children. None of 34 healthy controls showed a decrease of electrophoretic mobility of more than 5%, while all 10 children with malignant solid tumors showed a slowing of more than 5%. 3 of 54 patients with non malignant disease showed a slowing of more than 5% in the EM-test. Children with malignant solid tumors during therapy and children with leukemia during different stages of the disease often showed a slowing of less than 5% in the EM-test. The possible diagnostic help of the EM-test is shown in a case history. Finally some technical remarks are made on improving this test, and further studies are suggested.
D002465:Cell Movement; D002648:Child; D004586:Electrophoresis / Q000379:methods; D004827:Epilepsy / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000175:diagnosis; D008214:Lymphocytes; D004676:Myelin Basic Protein; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology
D004676:Myelin Basic Protein
Erafhrungen mid dem Elektrophorese-Mobilitäts-Test bei Kindern. Eine diagnostische Hilfe in der pädiatrischen Onkologie?