The influence of chemotherapy on the distribution of 57Co-bleomycin in chemically induced squamous cell carcinoma of mouse skin.
Organ distribution and tumor uptake of 57Co-bleomycin (BLM) were examined in NMRI mice without tumor and with chemically (DMBA-) induced squamous cell carcinoma. In these tumors high accumulation of 57Co-BLM was recorded shortly after injection of 57Co-BLM and low uptake 24--48 h after application. Two groups of tumor-bearing mice received unlabeled bleomycin as a cytostatic in two different doses. Uptake of 57Co-bleomycin was reduced. The study suggests that in patients currently or previously under chemotherapy, 57Co-bleomycin tumor scintigraphy may lead to false negative results.
D000818:Animals; D001761:Bleomycin / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism; D003037:Cobalt Radioisotopes / Q000378:metabolism*; D004358:Drug Therapy; D005188:False Negative Reactions; D008297:Male; D051379:Mice; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism; D014018:Tissue Distribution
D003037:Cobalt Radioisotopes; D001761:Bleomycin