title: [Production of purified foot-and-mouth disease virus antigens and the specific sera against them].
abstract: It was demonstrated that the use of laboratory techniques could be contributive to the production of purified antigens of the F.M.D. virus, such a-140 S, 12 S, and VIA. The isolated purified antigens were used to immunize guinea pigs, obtaining specific antisera against them. It was found that the latter contained specific complement-fixing and precipitating antibodies, while the 140 S serum also had neutralizing antibodies. The produced 140 S serum contained certain amounts of 12 S antibodies, which was considered to be the result of a spontaneous degradation of the 140 S antigen.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000302:isolation & purification*; D005537:Aphthovirus / Q000276:immunology*; D003168:Complement Fixation Tests; D000939:Epitopes; D006168:Guinea Pigs; D007106:Immune Sera / Q000302:isolation & purification*; D007114:Immunization; D009500:Neutralization Tests
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D007106:Immune Sera
vernacular_title: Poluchavane na prechisteni antigeni na shapniia virus i na spetsifichni serumi sreshtu tiakh.