Demonstration of cross-reacting tumor rejection antigens in chemically induced respiratory tract carcinomas in rats.
Experiments were performed to determine whether chemically induced rat respiratory tract carcinomas, which possess considerable immunogenicity, contain cross-reacting antigens. In vivo studies showed that effective cross-protection can be induced with four of the five respiratory tract cancers studied, suggesting that these tumors have common tumor rejection antigens. In vitro cytotoxicity studies with sera from tumor-immune hosts showed cross-reactivity among three of the carcinomas tested.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm / Q000032:analysis*; D001580:Benzopyrenes; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D002460:Cell Line; D003429:Cross Reactions; D006084:Graft Rejection; D066298:In Vitro Techniques; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced / Q000276:immunology*; D014185:Transplantation, Isogeneic
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001580:Benzopyrenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D012194:RNA-Directed DNA Polymerase