Lymphocyte subpopulations in man. Expression of HLA-DR determinants on human T cells in infectious mononucleosis.
In a study of lymphocyte subpopulations in peripheral blood during infectious mononucleosis the lymphocytosis was found to be of T-cell origin (i.e. E-RFC), while the number of non T lymphocytes (i.e. EA-, EAC-RFC and SmIg + ve cells) was normal in 7 out of 8 patients. Ten patients were tested for the presence of HLA-DR determinants on their B and T cells and not only B lymphocytes but also a great part (31--75%) of T cells were lysed by the anti HLA-DR testsera, indicating that HLA-DR determinants are expressed on a population of T cells in IM patients. After recovery all patients were retested and showed a normal pattern of HLA-DR typing. This indicates an increase of HLA-DR antigens on T cells or a vigorous proliferation of a small DR-positive T-cell subpopulation during the acute stage of IM.
D000042:Absorption; D000293:Adolescent; D000328:Adult; D000954:Antigens, Surface; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D000939:Epitopes; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D000939:Epitopes; D006680:HLA Antigens