Effects of a new glucocorticoid, oxazacort, on some variables connected with bone metabolism in man: a comparison with prednisone.
The urinary elimination of calcium, other electrolytes, and hydroxyproline and the oral absorption of 47Ca have been evaluated in three groups of 8 patients before and during a 15-day treatment with prednisone at daily doses of 25 and 50 mg and with oxazacort, a new glucocorticoid, at a daily dose of 50 mg. The results obtained demonstrate that oxazacort in short-term teatment with a high dose has no significant effect on the urinary elimination of calcium and hydroxypyroline in experimental conditions in which prednisone produces statistically significant and clinically relevant increase, both when given at the same dose and when given at half that dose. On the other hand, the oral absorption of 47Ca is decreased by oxazacort, but less than by prednisone at the same dose. As the antirheumatic activity of oxazacort appears to be only slightly lower than that of prednisone (activity ratio of about 0.84: 1), these findings may have interesting therapeutic implications.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010080:Oxazoles / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011241:Prednisone / Q000494:pharmacology*; D011244:Pregnadienediols / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D005938:Glucocorticoids; D010080:Oxazoles; D010710:Phosphates; D011244:Pregnadienediols; D012964:Sodium; D003404:Creatinine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D011188:Potassium; D002118:Calcium; D011241:Prednisone