[Anti-arrhythmic effect of tetrodotoxin in the late stage of experimental myocardial infarct].
The action of tetrodotoxin (TT), blocking the fast sodium current, on arrhythmias that occurred 24 hours after occlusion of the coronary artery was studied in 10 dogs. TT injected intravenously in doses of 0.5--3.0 micrograms/kg significantly decreased the number of ventricular extrasystoles, and completely restored sinum rhythm in 4 animals. The maximum antiarrhythmic effect was noted 3 to 5 minutes after TT adminstration. It is suggested that arrhythmias and the antiarrhythmic effect of the drugs in the late stage of myocardial infarction are connected with the fast inward sodium current.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D005117:Cardiac Complexes, Premature / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D011690:Purkinje Fibers / Q000503:physiopathology; D013779:Tetrodotoxin / Q000627:therapeutic use*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D013779:Tetrodotoxin
Antiaritmicheskoe deĭstvie tetrodotoksina v pozdneĭ stadii éksperimental'nogo infarkta miokarda.