Sucrose malabsorption in man after ingestion of alpha-glucosidehydrolase inhibitor.
The effect of an alpha-glucosidehydrolase inhibitor (alpha-G.H.I.) on intestinal absorption of sucrose was assessed by measuring rises in blood-glucose and intestinal hydrogen production after ingestion of 100 g sucrose. 200 mg alpha-G.H.I. given with the sucrose completely inhibited early postprandial blood-glucose rises, prevented late postprandial dips in blood-glucose, and considerably increased breath-hydrogen levels, which indicates sucrose malabsorption. Thus the inhibitor can be used to study carbohydrate malabsorption and may be useful as a method for retarding carbohydrate absorption.
D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000037:antagonists & inhibitors; D001944:Breath Tests; D003903:Deuterium / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007408:Intestinal Absorption / Q000187:drug effects; D008286:Malabsorption Syndromes / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D013395:Sucrose; D003903:Deuterium; D005959:Glucosidases