title: [Experimental analysis of the complement-binding activity of gamma-globulin].
abstract: It was experimentally demonstrated that the anticomplimentary characteristics of gamma-globulin perparations was associated with disturbances of the colloid condition of the serum system and the absence of any stabilizing action of albumin and other serum proteins. It is also expressed as a result of a high complement-binding activity of protein aggregates. The anticomplementary characteristics of the nonaggregated part of protein in commercial preparations of gamma-globulin could be depressed by the addition of albumin or fresh serum; as to the anticomplementary characteristics of protein aggregates -- it remains unchanged. An intermolecular electrostatic interaction exists between albumin and gamma-globulin; it prevents sorption of the complement on Fc-fragment of IgG, whose destruction leads to the manifestation of the gamma-globulin complement-binding activity.
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D003102:Colloids; D003169:Complement Inactivator Proteins / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D007141:Immunoglobulin Fc Fragments; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D005719:gamma-Globulins / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D003102:Colloids; D003169:Complement Inactivator Proteins; D007141:Immunoglobulin Fc Fragments; D012709:Serum Albumin; D005719:gamma-Globulins; D003165:Complement System Proteins
vernacular_title: Eksperimental'nyĭ analiz komplementsviazyvaiushcheĭ aktivnosti gamma-globulina.