title: Lactate--a suppressor of differentiation in embryonic cells.
abstract: All kinds of visible differentiation in cultured amphibian embryonic cells are suppressed in the presence of lactate. This effect differs in certain respects from that observed with actinomycin, but like the latter lactate inhibits RNA synthesis. In this communication we present some further observations on the effect of lactate.
mesh_terms: D000557:Ambystoma / Q000196:embryology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology; D007773:Lactates / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D012335:RNA, Ribosomal / Q000096:biosynthesis; D014529:Uridine / Q000378:metabolism
chemical_list: D007773:Lactates; D012335:RNA, Ribosomal; D003609:Dactinomycin; D012313:RNA; D014529:Uridine