title: Thyroid function in primary depression.
abstract: The thyroid function of 20 female inpatients with primary depression was investigated by the following tests: serum thyroxine, in vitro radioactive triiodothyronine uptake, free-thyroxine index, thyroidal 131I uptake and 48 hours protein-bound 131I. The mean values of serum thyroxine, free-thyroxine index and thyroidal 131I uptake of the patients were found decreased, compared to those of the euthyroid controls (to a statistically significant level for serum thyroxine and free-thyroxine index P less than .001). These findings point to a decreased thyroid activity in primary depression. The possibility of implication of a common neurochemical mechanism in both primary depression and thyroid hypoactivity was discussed.
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine