[Absorption, excretion, distribution and metabolism of 3H-labelled pepleomycin sulfate (author's transl)].
Absorption, excretion, distribution and metabolism of pepleomycin sulfate (NK631) were investigated in rats after intravenous administration of 3H-NK631 by whole-body autoradiography, CM-Sephadex column chromatography and high performance liquid chromatography. The highest radioactivity was found in kidney, followed by cartilage, blood, lung, esophagus, adrenal gland and skin at 0.5 hour after the administration and little radioactivity was observed in central nerve system. The NK631 and deamide NK631 were identified as major (90%) and minor metabolites in the 24-hour urine.
D000042:Absorption; D000818:Animals; D001345:Autoradiography; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D005260:Female; D007275:Injections, Intravenous; D007553:Isotope Labeling; D008297:Male; D008431:Maternal-Fetal Exchange; D009374:Neoplasms, Experimental / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D001761:Bleomycin