Induction of interferon synthesis in mice by fractions from Nocardia.
Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h after injection. The interferon induced by NSWMP and NWSM was acid stable and antigenically related to viral interferon, as shown by neutralization with antibodies directed against Newcastle disease virus-induced interferon.
D000818:Animals; D000939:Epitopes; D005260:Female; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood* / Q000276:immunology; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D009615:Nocardia; D010457:Peptidoglycan / Q000494:pharmacology*; D012995:Solubility; D013347:Subcellular Fractions; D014867:Water
D000939:Epitopes; D007369:Interferon Inducers; D008934:Mitogens; D010457:Peptidoglycan; D014867:Water; D007372:Interferons