Cell surface changes in HeLa cells as an indication of cell cycle events.
A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to that of synchronized cells in the same phase. The results indicated a close association between the cell surface topography and the cycles of DNA synthesis in the cell nucleus of this HeLa line.
D001761:Bleomycin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D003561:Cytarabine / Q000494:pharmacology; D006367:HeLa Cells / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D006918:Hydroxyurea / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D008937:Mitomycins / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology
D008937:Mitomycins; D003561:Cytarabine; D001761:Bleomycin; D014747:Vinblastine; D013936:Thymidine; D006854:Hydrocortisone; D006918:Hydroxyurea