Hypoimmunoglobulinaemia with deficiency of pre-B cells.
No pre-B cells were found in the marrows of two girls with congenital antibody deficiency who lacked B cells. The presence of variable T-lymphocyte defects in these and thymoma patients lacking pre-B cells favours a metabolic aetiology rather than selective failure of a single cell series.
D000361:Agammaglobulinemia / Q000097:blood / Q000150:complications* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007075:Immunoglobulin M; D007958:Leukocyte Count; D008231:Lymphopenia / Q000097:blood / Q000276:immunology; D008297:Male; D011947:Receptors, Antigen, B-Cell
D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell