Glucose and cation transport in rat jejunum, ileum and colon in vivo: effects of anionic and nonionic surfactants, and of desoxycholate.
Osmotically balanced solutions of glucose (0.5--300 mM) and sodium chloride, containing surfactants, were instilled into the small or large intestine of anaesthetized rats. Net absorption or secretion of glucose, sodium and potassium was studied. The surfactants tested were dodecylsulphate (3.4--17 mM), dioctylsulphosuccinate (1.8--11 m/M), Lubrol WX (0.1--5%), Triton X 100 (0.25%) and desoxycholate (2.5 mM). Qualitatively, the results were similar to those obtained previously with cationic compounds, suggesting a common mode of action for all surfactants studied. 17 mM dodecylsulphate seemed to abolish completely physiological glucose transport in the jejunum and ileum. At a lower concentration, and witth the other surfactants, normal glucose transport was affected to an intermediate extent.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002412:Cations; D003106:Colon / Q000378:metabolism; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004143:Dioctyl Sulfosuccinic Acid / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D011092:Polyethylene Glycols / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012965:Sodium Chloride / Q000378:metabolism; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology*
D002412:Cations; D013501:Surface-Active Agents; D003840:Deoxycholic Acid; D004143:Dioctyl Sulfosuccinic Acid; D012967:Sodium Dodecyl Sulfate; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D005947:Glucose; D011188:Potassium