Failure of tranexamic acid to influence the ellagic acid-induced hypercoagulable state.
Tranexamic acid in a dose of 50 mg/kg b.w. was unable to alter the ellagic acid induced hypercoagulable state. No change in the hypercoagulability pattern was observed regardless of the time of administration of the compound (before or after the ellagic infusion). The silicone clotting times after the infusion of ellagic acid were markedly shortened and remained so for about 60 minutes. The results observed in two control groups treated with saline were similar. The euglobulin lysis times were clearly prolonged after the administration of tranexamic acid, whereas no changes were observed after the administration of saline. These results indicate that tranexamic acid has no anti-factor XII activity.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D004285:Dogs; D004610:Ellagic Acid; D005174:Factor XII / Q000037:antagonists & inhibitors; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D014148:Tranexamic Acid / Q000494:pharmacology*
D003509:Cyclohexanecarboxylic Acids; D004610:Ellagic Acid; D014148:Tranexamic Acid; D005174:Factor XII