Circulating thymic-hormone activity in congenital immunodeficiency.
Circulating thymic-hormone activity was assayed by measuring Thy 1-2 antigen induction on null lymphocytes from athymic mice incubated with human plasma or serum. Plasma from 19 normal children aged under 10 had inductive activity equivalent to 10-6-16-2 ng thymopoitin/ml. Plasma from 15 infants were severe combined immuno-deficiency, 2 of whom had appreciable immunoglobulin synthesis, and from 2 infants with DiGeorge syndrome had little or no inductive activity. Successful reconstitution with thymus or bone-marrow grafts and with red-cell infusions (if adenosine-deaminase deficiency is present) was followed by a rise in circulating thymic-hormone activity.
D000361:Agammaglobulinemia / Q000151:congenital / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D001681:Biological Assay; D001803:Blood Transfusion; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D004062:DiGeorge Syndrome / Q000151:congenital / Q000503:physiopathology / Q000628:therapy; D004912:Erythrocytes; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000151:congenital* / Q000503:physiopathology / Q000628:therapy; D007223:Infant; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D013946:Thymopoietins / Q000378:metabolism*; D013950:Thymus Gland / Q000002:abnormalities / Q000503:physiopathology / Q000637:transplantation; D013951:Thymus Hormones / Q000378:metabolism*; D014184:Transplantation, Homologous
D013946:Thymopoietins; D013951:Thymus Hormones