title: Treatment of duodenal ulcer by metiamide. A multicentre trial.
abstract: In a multicentre double-blind trial 68 patients with endoscopically confirmed duodenal ulceration received metiamide (36 patients) or placebo (32 patients) for four weeks. Healing of duodenal ulcers was significantly increased in patients receiving metiamide (67%) compared with those on placebo (25%). There was also an assoicated significant decrease in daytime pain and antacid consumption in those on metiamide.
mesh_terms: D000863:Antacids / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004378:Duodenal Diseases / Q000188:drug therapy; D004381:Duodenal Ulcer / Q000188:drug therapy*; D004751:Enteritis / Q000188:drug therapy; D006801:Humans; D008785:Metiamide / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy; D013890:Thiourea / Q000031:analogs & derivatives*
chemical_list: D000863:Antacids; D008785:Metiamide; D013890:Thiourea