IgA immune complexes in Henoch-Schönlein purpura.
Raised levels of IgA immune complexes were found in 13 of 18 children with Henoch-Schönlein purpura irrespective of whether they developed nephritis or not. In contrast, only those children who developed nephritis had raised levels of IgG immune complexes as well. In 2 children with nephritis, two discrete peaks of IgA complexes were found, corresponding to 4 x 10(5) to 8 x 10(5) and 2.5 x 10(6) to 4 x 10(6) daltons. IgG complexes were found only in the larger-molecular-weight peak. Such differences in immune complexes may underlie the different manifestations of this disease.
D000293:Adolescent; D000936:Antigen-Antibody Complex; D002648:Child; D002675:Child, Preschool; D003172:Complement C1 / Q000032:analysis; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D011695:IgA Vasculitis / Q000150:complications / Q000276:immunology*; D007105:Immune Complex Diseases / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009393:Nephritis / Q000209:etiology / Q000276:immunology
D000936:Antigen-Antibody Complex; D003172:Complement C1; D007070:Immunoglobulin A; D007074:Immunoglobulin G