Comparison of vitamin D and 25-hydroxy-vitamin-D in the therapy of primary biliary cirrhosis.
Skeletal demineralisation and low serum concentrations of 25-hydroxy-vitamin-D were observed in patients with primary biliary cirrhosis. Neither oral nor parenteral vitamin-D increased 25-hydroxy-vitamin-D in serum or prevented further skeletal demineralisation. In contrast, oral 25-hydroxy-vitamin-D increased serum-25-hydroxy-vitamin D concentrations in all patients, and bone mineral content either improved or stabilised in all but one, 25-hydroxy-vitamin-D may be the preferred form of vitamin-D therapy in primary biliary cirrhosis.
D000284:Administration, Oral; D000328:Adult; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002118:Calcium