title: Failure of saralasin to predict a response to surgery in renovascular hypertension.
abstract: Arteriography in two patients with renovascular hypertension suggested fibromuscular hyperplasia, mainly affecting the right renal artery. When saralasin was infused intravenously there was no fall in blood-pressure in either patient. However, both had a raised renal-vein plasma-renin activity on the affected side, relative to the unaffected kidney. Auto-transplantation resulted in a sustained reduction in arterial pressure in both patients. A negative saralasin test should not necessarily exclude further investigation of young patients with severe hypertension.
mesh_terms: D000328:Adult; D000792:Angiography; D000804:Angiotensin II / Q000031:analogs & derivatives*; D001794:Blood Pressure; D001795:Blood Pressure Determination; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D006977:Hypertension, Renal / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D008297:Male; D011379:Prognosis; D012077:Renal Artery / Q000473:pathology; D012082:Renal Veins; D012083:Renin / Q000097:blood; D012504:Saralasin; D014182:Transplantation, Autologous
chemical_list: D000804:Angiotensin II; D012083:Renin; D012504:Saralasin