title: Banding and spiralization of human metaphase chromosomes.
abstract: A new technique is described which produces spiralization of human metaphase chromosomes. The important feature is heat followed by trypsin treatment. By varying conditions, it is possible to produce bands, spirals and intermediate stages. This provides a new approach to the understanding of banding and chromosome structure.
mesh_terms: D002875:Chromosomes / Q000032:analysis*; D006358:Hot Temperature; D006801:Humans; D008938:Mitosis; D013194:Staining and Labeling; D014357:Trypsin
chemical_list: D014357:Trypsin