Distinct target determinants on two lymphoblastoid lines derived from the same individual1.
Specifically cytotoxic cells were generated in undirectional mixed leukocyte culture against both T and B lymphoblastoid cell lines. The cytotoxicity observed included both specific and less selective components which were differentiated by the interaction analysis based on the two-way analysis of variance. The results indicate that a T cell line and a B cell line derived from the same person possessed distinct target specificities. The antigens detected by direct cytotoxicity were confirmed by inhibition studies with competitor cells.
D002460:Cell Line; D002469:Cell Separation; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens