Recognition of lysozyme by lymphocyte subsets.
Extensive studies with antisera from a variety of animals have failed to detect any cross-reactivity between egg white lysozyme and its reduced, S-carboxymethylated (CM-) derivative. In contrast, a number of studies addressing the specificity of T lymphocytes have revealed that these two forms of lysozyme cross-react rather extensively at that level. Preliminary attempts to eliminate this latter cross-reactivity by further denaturation and/or chemical modification have so far proven unsuccessful. In a second line of experimentation the response to CM-lysozyme of mice which are genetically unresponsive to native lysozyme was assessed and found deficient. The implications of these findings are discussed.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002464:Cell Migration Inhibition; D000939:Epitopes; D006241:Haptens; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D009113:Muramidase / Q000276:immunology*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006241:Haptens; D009113:Muramidase