[Effect of the nude mutation on alpha-fetoprotein synthesis and hemopoiesis in the mouse liver in the postnatal period of development].
The dynamics of population of alpha-fetoprotein (AFP)-containing cells in the liver and the level of AFP in the blood of C3H/HeJ+/+ and thymus-less mutant C3H/HeJnu/nu mice during postnatal development was studied by means of indirect immunofluorescence and radial immunodiffusion. The content of AFP-positive hepatocytes and AFP concentration in the blood serum of C3H/HeJnu/nu mice were shown to exceed markedly those in C3H/HeJ+/+ mice beginning from the age of 2 weeks. The histological analyses has revealed the foci of hemopoiesis in the liver of adult C3H/HeJnu/nu mice, unlike in the liver of normal mice. The neonatal thymectomy of C3H/HeJ+/+ mice did not influence the parameters under study. A possible relationship between the increased AFP level and the preservation of hemopoiesis in the liver of the mice homozygous by the mutation nude is discussed.
D000818:Animals; D003433:Crosses, Genetic; D006410:Hematopoiesis; D006720:Homozygote; D008099:Liver / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude / Q000502:physiology*; D009154:Mutation; D013934:Thymectomy; D000509:alpha-Fetoproteins / Q000096:biosynthesis* / Q000097:blood
D000509:alpha-Fetoproteins
Vliianie mutatsii nude na sintez al'fa-fetoproteina i gempoéz v pecheni mysheĭ v postnatal'nom periode razvitiia.