title: [Principle of constructing polyvalent Pseudomonas aeruginosa vaccines].
abstract: Dependence of the range of protective action of P. aeruginosa vaccine on the number of its composites was studied. A principle of the selection of strains who vaccines differed in vivo by immunological specificity was applied to construction of the experimental preparations and modelling a polyvalent vaccine. Increase of the number of components in the vaccine was accompanied by increase of its protective action range. However, with the increase of the number of polyvaccine components in the polyvaccine the accretion of the protective effect expressed in the mean protective index per component displayed a gradual reduction. It was calculated theoretically that a 6--7-component vaccine should provide protection from 94--96% of the P. aeruginosa strains; as to further increase of the number of components--it would induce overloading of the vaccine with a possible absence of any effect.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D000939:Epitopes; D007110:Immunity, Active / Q000187:drug effects; D007114:Immunization; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D000939:Epitopes
vernacular_title: Printsip konstruirovaniia polivalentnykh vaktsin Pseudomonas aeruginosa.