Effect of triac on the developing heart.
Triac (diethanolamine salt of triiodothyroacetic acid) was administered by intramuscular injection to 12 pregnant female rats. These were divided into a control group and three other groups, each receiving different doses of triac. The effect of triac on the hearts of their offspring was studied morphologically. Histological examination showed evidence of only mild hypertrophy, but ultrastructurally, disarray of myocardial fibrils and other changes similar to those observed in patients with hypertrophic cardiomyopathy were found in the litter of the group receiving the highest dose. It is suggested that thyroid function should be studied in patients with obscure cardiac disease.
D000818:Animals; D000831:Animals, Newborn; D006332:Cardiomegaly / Q000139:chemically induced* / Q000196:embryology / Q000473:pathology; D003110:Colonic Neoplasms / Q000453:epidemiology*; D004983:Ethanolamines / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D007273:Injections, Intramuscular; D009206:Myocardium / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D014284:Triiodothyronine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology
D004983:Ethanolamines; D014284:Triiodothyronine