title: Evolutionary relationships between gag gene-coded proteins of murine and primate endogenous type C RNA viruses.
abstract: Several low molecular weight proteins of endogenous type C viruses of the RD114/baboon group are compared with the gag gene translational products of endogenous type C viruses of murine origin. The p10 proteins of each virus group are shown to be immunologically and biochemically related, while the p12 proteins of RD114/baboon viruses are demonstrated to share antigenic determinants with murine viral p15. Moreover, highly type-specific phosphoproteins, p15 of RD114/baboon viruses and p12 of murine viruses, are shown to possess very similar biochemical properties. These findings, along with previous studies indicating immunologic cross-reactivity between their major internal antigens, p30, demonstrate that each of the gag gene-coded proteins of murine type C viruses has a analogue in viruses of the RD114/baboon group. The immunologic and biochemical relatedness of their gag gene translational products supports the concept of a common progenitor in the evolution of these endogenous viruses.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002415:Cats; D003429:Cross Reactions; D000939:Epitopes; D005796:Genes; D000882:Haplorhini; D051379:Mice; D008970:Molecular Weight; D014176:Protein Biosynthesis; D012328:RNA Viruses / Q000032:analysis* / Q000276:immunology; D011925:Rauscher Virus / Q000032:analysis / Q000276:immunology; D012190:Retroviridae / Q000032:analysis* / Q000276:immunology; D014764:Viral Proteins / Q000032:analysis* / Q000276:immunology
chemical_list: D000939:Epitopes; D014764:Viral Proteins