title: Chicken high molecular weight immunoglobulin (IgM) allotypes: localization on the heavy chains and proposed nomenclature.
abstract: An alloantiserum recognizing a genetic marker (CM-1.4) on chicken 17S Ig was generated by immunizing jungle fowl with Salmonella O-anti-Salmonella O (UCD 3) agglutinates. Specificities CM-1.4 and M1a were present on 7S subunits and H chains based on their ability to inhibit in RIA the binding of alloantibody (anti-CM-1.4 or anti-M1a) to UCD 3 125I-17S Ig. CM-1.4 appears to be fully expressed on 7S subunits but is altered on H chains. In contrast, anti-M1a bound both 7S subunits and H chains with decreased avidity indicating that the M1a specificity was altered in both preparations. Since CM-1.4 and M1a are present on 17S Ig H chains, and absent from 7S Ig, they probably represent allotypic markers in the constant region of 17S Ig H chains. Having assigned two 17S Ig allotypic specificities to H chains, we propose that the locus controlling their expression be called CM-1. Based on the distribution of the CM-1.4 and M1a allotypes in inbred lines of chickens, 3 alleles are defined at the CM-1 locus.
mesh_terms: D000483:Alleles; D000818:Animals; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000145:classification / Q000235:genetics*; D007148:Immunoglobulin mu-Chains / Q000096:biosynthesis / Q000145:classification / Q000235:genetics; D011110:Polymorphism, Genetic; D009626:Terminology as Topic
chemical_list: D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007075:Immunoglobulin M; D007148:Immunoglobulin mu-Chains