Potentiation of cutaneous reactivity and blood leucocyte histamine release by deuterium oxide in human beings.
Deuterium oxide (D2O) is known to potentiate non-cytotoxic histamine release in vitro. It has been shown (5) that D2O could also potentiate in vivo immediate-type hypersensitivity in dogs and monkeys. Present studies demonstrate potentiation in vivo by D2O of the cutaneous reactivity in 48/80, PHA and Dermatophagoides cutaneous reactions in human beings. PHA histamine release from human leucocytes is also potentiated by D2O in vitro.
D003903:Deuterium / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D037102:Lectins / Q000494:pharmacology; D007962:Leukocytes / Q000378:metabolism*; D008925:Mites / Q000276:immunology; D012882:Skin Tests; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D037102:Lectins; D003189:p-Methoxy-N-methylphenethylamine; D003903:Deuterium