Blood-transfusions induce prolonged kidney allograft survival in rhesus monkeys.
A prospective study has been carried out in rhesus monkeys to investigate the influence of blood-transfusions on kidney allograft survival. Unrelated animals matched for 2 or 3 antigens of the A and B locus of the major histocompatibility complex were given five consecutive blood-transfusions before transplantation and received conventional immunosuppressive treatment. Transfused recipients showed a four-fold increase in mean survival time compared with the non-transfused controls. These results may contribute to a change of policy regarding blood-transfusions in transplant patients.
D000818:Animals; D000917:Antibody Formation; D001379:Azathioprine / Q000627:therapeutic use; D001803:Blood Transfusion; D005260:Female; D006085:Graft Survival; D000882:Haplorhini; D006649:Histocompatibility Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D007668:Kidney / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D008297:Male; D011182:Postoperative Care; D011239:Prednisolone / Q000627:therapeutic use; D011300:Preoperative Care; D011446:Prospective Studies; D013997:Time Factors; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D011239:Prednisolone; D001379:Azathioprine