title: Osteosarcoma complicating Paget's disease of the spine with neurologic complications.
abstract: An osteosarcoma with neurologic manifestations complicated Paget's disease of the lumbar spine in a 63-year-old man. Initially without demonstrable metastasis, the patient was treated by decompressive laminectomy followed by radiation and adjuvant chemotherapy (COMPADRI-1 regimen). While such treatment may not be curative, there are significant palliative benefits.
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010001:Osteitis Deformans / Q000150:complications* / Q000000981:diagnostic imaging; D012516:Osteosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D010166:Palliative Care; D011859:Radiography; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D013122:Spinal Diseases / Q000150:complications* / Q000000981:diagnostic imaging