Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.
Antiserum against normal human neurotubules purified by in-vitro assembly precipitated both neurotubules and a polypeptide isolated from Alzheimer neurofibrillary tangles in Ouchterlony double-diffusion tests. The antiserum specifically labelled neurofibrillary tangles, in isolated neurons by immunofluorescence and in tissue sections by the peroxidase-antiperoxidase technique. These results indicate that neurofibrillary tangles in Alzheimer's disease probably originate from neurotubules.
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D002648:Child; D003704:Dementia / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D008297:Male; D009454:Neurofibrils / Q000276:immunology; D009474:Neurons / Q000473:pathology*; D011817:Rabbits
D007106:Immune Sera