Inhibition of rat mast cell degranulation and histamine release by histamine-rat gammaglobulin conjugate.
Histamin-rat-gamma-globulin conjugate inhibited degranulation and histamine release of rat peritoneal mast cells to a greater extent than the rat globulin or histamine alone. Since mast cells contain histamine receptors, it may be assumed that the histamine bound to the gamma-globulin combines with the rat mast cell histamine receptor and inhibits the degranulation and histamine release by a feedback mechanism.
D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects; D005260:Female; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011968:Receptors, Histamine / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism / Q000494:pharmacology
D011968:Receptors, Histamine; D005719:gamma-Globulins; D006632:Histamine