Experimental studies on hydrocarbon neuropathies induced by methyl-ethyl-ketone (MEK).
An outbreak of neuropathies among Berlin solvent sniffers was closely related to the denaturation by methyl-ethyl-ketone (MEK) of the mixture used. The solvent was composed of n-hexane, toluene and ethyl-acetate. Nervous system responses to chronic repeated exposure to 10,000 ppm pure n-hexane, 10,000 ppm MEK/n-hexane (ratio 1:9) and 6000 ppm pure MEK were investigated in rats. Motor neuropathy of the dying back type with giant swelling of axons in the peripheral and central nervous system developed in animals exposed to MEK/n-hexane and n-hexane. Severe potentiation of n-hexane neurotoxicity and shortened onset of morphological and clinical signs were demonstrated in animals exposed to MEK/n-hexane. MEK alone did not produce neuropathy under these conditions. The findings suggest that commercial solvent mixtures containing MEK/n-hexane should be avoided.
D000281:Administration, Intranasal; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D004347:Drug Interactions; D006586:Hexanes / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D007659:Ketones / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009186:Myelin Sheath / Q000648:ultrastructure; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology; D051381:Rats; D012997:Solvents / Q000633:toxicity*; D019966:Substance-Related Disorders
D006586:Hexanes; D007659:Ketones; D012997:Solvents