An animal model for the growth of human tumor cell lines.
Newborn rats were thymectomized at less than 24 hr of age and received antilymphocyte serum and heterologous human tumor cells. This model allows the growth of large primary tumors with a high metastatic percentage. This model may be applicable to the study of a wide variety of genitourinary tumors.
D000818:Animals; D000831:Animals, Newborn; D000961:Antilymphocyte Serum; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D002460:Cell Line; D004195:Disease Models, Animal; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013934:Thymectomy; D014183:Transplantation, Heterologous; D001749:Urinary Bladder Neoplasms / Q000473:pathology
D000961:Antilymphocyte Serum