Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome.
In a study of HLA types in Caucasian patients with nephritis due to antibodies to glomerular basement membrane, antigen frequencies at A, B, or CW loci were normal. However, 15 out of 17 (88%) patients to whom DRW types were definitely assigned had HLA-DRW2 compared with 32 out of 100 Caucasian blood-donors. This difference is highly significant.
D019867:Anti-Glomerular Basement Membrane Disease / Q000209:etiology* / Q000276:immunology; D001323:Autoantibodies / Q000302:isolation & purification; D001324:Autoantigens; D001327:Autoimmune Diseases; D001485:Basement Membrane / Q000276:immunology; D003429:Cross Reactions; D006680:HLA Antigens / Q000302:isolation & purification; D006650:Histocompatibility Testing; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D006680:HLA Antigens