Urinary excretion of hydromorphone and metabolites in humans, rats, dogs, guinea pigs, and rabbits.
Hydromorphone was administered as a single dose to humans, rats, dogs, guinea pigs, and rabbits, and timed urinary collections were made. GLC-mass spectrometric and GLC analyses of the samples revealed the presence of the parent compound and both 6-hydroxy epimers as metabolites in the urine of all species. Free or conjugated parent drug predominated, while levels of free or conjugated 6beta-hydroxy metabolite were higher than or equal to those of the 6alpha-form. The time courses of excretion of drug and metabolites were similar for all species, with the major portion being excreted in the first 24 hr. Generally, free and conjugated drug were undetectable in human urine after 8 and 48 hr, respectively.
D000328:Adult; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D004091:Hydromorphone / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D011817:Rabbits; D051381:Rats
D004091:Hydromorphone