The effect of anti-eosinophil serum on skin histamine replenishment following passive cutaneous anaphylaxis in the guinea-pig.
Depletion of eosinophils by an antieosinophil serum resulted in the inhibition of histamine reaccumulation into guinea-pig skin sites following IgG1-mediated passive cutaneous anaphylaxis. This suggests that eosinophils may have a regulatory role in the repair mechanism which follows immediate-type hypersensitivity reactions.
D000818:Animals; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D006636:Histamine Release; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G; D008297:Male; D010323:Passive Cutaneous Anaphylaxis; D012867:Skin / Q000276:immunology / Q000378:metabolism
D007106:Immune Sera; D007074:Immunoglobulin G; D006632:Histamine