Allergic reactions, cyclic AMP and histamine release.
Both isobutylmethylxanthine and theophylline increased the level cyclic AMP in the mast cell. Theophylline reduced the allergic histamine release, whereas isobutylmethylxynthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is too simple.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects; D006967:Hypersensitivity / Q000378:metabolism*; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D014970:Xanthines; D013806:Theophylline; D000242:Cyclic AMP