title: Intra-amniotic urea and prostaglandin F2alpha for midtrimester abortion: clinical and laboratory evaluation.
abstract: The clinical management of the elective midtrimester abortion continues to be unsatisfactory as judged by either national mortality or morbidity rates. This report documents the results of a randomized series of 19 midtrimester abortions induced by either intra-amniotic hyperosmolar urea and 5 mg. of prostaglandin F2alpha (PGF2alpha) or intra-amniotic hyperosmolar urea alone. Pertinent clinical characteristics and biochemical determinations were compared between these two groups. A series of 150 patients were then treated with urea and 5 mg. of PGF2alpha. The clinical results of this series of patients are presented and compared with a previous group who had urea and 10 mg. of PGF2alpha. These studies demonstrate that 5 mg. of PGF2alpha with 80 Gm. of urea achieves injection-abortion intervals that are less than 24 hours.
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000650:Amnion; D001806:Blood Urea Nitrogen; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors; D014508:Urea / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D011460:Prostaglandins F; D000509:alpha-Fetoproteins; D014508:Urea