The craniofacial skeleton in anencephalic human fetuses. II. Calvarium.
A detailed study of the calvarium of twelve anencephalic and four normal human fetuses 26 to 40 weeks gestational age using gross dissection, alizarin red S staining, silver nitrate radiography and histology revealed dramatic alterations in the presence, form, location and relationship of the individual bones. In the larger dorsal cranial defects the interparietal portions of the occipital bone were relocated anteriorly to approximate the frontal bone. The occipital components were rotated anterolaterally and inferiorly with lack of fusion of the chondrocranium posterior to the foramen magnum. The squamae of the frontal bone were collapsed horizontally and reduced in size to lie peripheral to the anterior cranial fossa forming most of the orbital roofs. In anencephaly the bones derived from the chondrocranium were not as severely affected morphologically as those derived from the neurocranium. The sutures were narrow and smooth instead of wide and serrated as in the normally developing calvarium. In general the degree of maldevelopment was proportional to the extent of the dorsal cranial defect in anencephaly.
D000757:Anencephaly / Q000196:embryology* / Q000473:pathology; D005260:Female; D005624:Frontal Bone / Q000196:embryology / Q000473:pathology; D006801:Humans; D009777:Occipital Bone / Q000196:embryology / Q000473:pathology; D011247:Pregnancy; D012886:Skull / Q000196:embryology*; D013194:Staining and Labeling