[Role of macrophages in the immune response to soluble protein antigen and in staphylococcal infection].
In experiments on rabbits immunized with soluble protein antigen immune reactions were found to be accompanied by the production of lipofuscin in macrophages. This process was the morphological manifestation of the digestion of antigen by macrophages which thus acquired the ability to migrate in the organ and to form lymphoid follicules in the medullary zone of lymph nodes. The newly formed follicules seem to be the basis of pronounced specific immune response. In staphylococcal bacteriemia the phagocytic activity of macrophages was delayed, thus causing disturbances in lipofuscin production; as a result, the subsequent phases of immune response also lagged somewhat behind in time.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology*; D002465:Cell Movement; D006801:Humans; D007114:Immunization; D008062:Lipofuscin / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008457:Measles / Q000276:immunology; D011817:Rabbits; D012995:Solubility; D013154:Spleen / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors; D005719:gamma-Globulins / Q000276:immunology*
D000941:Antigens; D008062:Lipofuscin; D005719:gamma-Globulins
Rol' makrofagov pri immunnom otvete na belkovyĭ rastvorimyĭ antigen i pri stafilokokkovoĭ infektsii.