[Decreased anaphylactogenic properties of disaggregated gamma-globulin].
Immunological properties of native, aggregated, and disaggregated (tolerogenic) human gamma-globulin were compared in experiments on mice and guinea pigs. Disaggregated preparation was shown to give diminished local and general hypersensitivity reaction in sensitized animals and had decreased ability to induce secondary humoral immune response.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D004342:Drug Hypersensitivity; D006168:Guinea Pigs; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D011489:Protein Denaturation; D005719:gamma-Globulins / Q000276:immunology*
D005719:gamma-Globulins
Snizhennye anafilaktogennye svoĭstva dezagregirovannogo gamma-globulina.