Prevention of plasmin autodigestion by human plasma alpha2-macroglobulin.
The autodigestion of plasmin in neutral solution at 37 degrees C and prevention of plasmin autodigestion by methylamine were confirmed by using rho-Tosyl-L-Arginine-Methyl ester as a substrate of plasmin. The autodigestion of plasmin was prevented by human plasma alpha2-macroglobulin which has been reported as an antiplasmin of immediate and reversible type but was not prevented by alpha1-antitrypsin which has been reported as an antiplasmin of slow and irreversible type.
D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D008744:Methylamines; D010958:Plasminogen; D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator; D000511:alpha-Macroglobulins / Q000302:isolation & purification
D008744:Methylamines; D000511:alpha-Macroglobulins; D010958:Plasminogen; D013300:Streptokinase; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator