[Activity of acid protease in subcellular fractions of dog brain with intracysternal administration of antibodies].
The intracysternal administration of the immunoglobulins G fraction containing mainly antiboides to myelin basic protein activites acid protease in the lysosomic, soluble fractions and in myelin of the brain white matter and spinal cord of dogs. Administration of the fraction of immunoglobulins G obtained from the intact dog blood serum does not change (with some exception) the protease activity. Therefore, a definite specificity is observed in the reaction of the acid protease activation when the brain is affected by antibodies to the myelin basic protein.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D004285:Dogs; D004789:Enzyme Activation; D007074:Immunoglobulin G; D008247:Lysosomes / Q000201:enzymology; D004676:Myelin Basic Protein / Q000276:immunology*; D009186:Myelin Sheath / Q000201:enzymology; D010447:Peptide Hydrolases / Q000378:metabolism*; D013347:Subcellular Fractions / Q000201:enzymology
D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D010447:Peptide Hydrolases
Aktivnost' kisloĭ proteazy subkletochnykh fraktsii mozga sobak pri vnutritsisternal' nom vvedenii antitel.