title: [Experience with polychemotherapy based on cell synchronization, via intra-arterial infusions. Preoperative treatment of maxillofacial tumors].
abstract: Chemotherapy based upon cellular synchronisation via intra-arterial infusion was used in the treatment of 21 carcinomas of the maxillo-facial region. These tumours had never been treated either by surgery, nor by irradiation. This pre-operative treatment was not aimed at altering ghe indication for the type of operation decided upon at the outset. It was found that a combination of Vincristine, Bleomycine, Methotrexate and Dibromdulcide was more satisfactory than other types of chemotherapy. The most important complication of the method was a thrombosis of the common carotid.
mesh_terms: D001761:Bleomycin / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D004359:Drug Therapy, Combination; D005153:Facial Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007573:Jaw Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D014062:Tongue Neoplasms / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014750:Vincristine; D008727:Methotrexate
vernacular_title: Expérience de polychimiothérapie basée sur la "synchronisation" cellulaire, par infusion intra-artérielle. Traitement pré-opératoire des tumeurs maxillo-faciales.