Specific inhibition of XC syncytia formation by anti-MuLV gp69/71 antibodies.
The XC syncytia formation observed when ecotropic murine leukemia virus producer cells were cocultivated with XC cells was specifically inhibited by anti-MuLV gp69/71 antibodies with type- or group-specific activities. Thus, the major glycoprotein of budding viruses was probably responsible for the fusion with XC cells. Since this inhibition is specific for anti-gp69/71, it provides a simple, sensitive and convenient way to type ecotropic type C viruses and to detect anti-gp69/71. The micromethod we have developed has been applied to the detection of type-specific anti-GLV gp69/71 natural antibodies in the serum of normal mice.
D000818:Animals; D000914:Antibodies, Viral; D002459:Cell Fusion; D002460:Cell Line; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology*; D009052:Leukemia Virus, Murine / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D006023:Glycoproteins; D010455:Peptides; D014764:Viral Proteins