[Evaluation of the antigenic structural changes in the rat liver after a single carcinogenic exposure].
A single injection of hepatocarcinogen (4-dimethylaminoazobenzene) to rats resulted in antigenic rearrangement in rat liver, typical of hepatocellular tumors, whereas the treatment with a non-carcinogen isomere (4-diethylaminoazobenzene) did not have the same effect. It is assumed that antigenic rearrangement in hepatocytes caused by 4-dimethylaminoazobenzene might be due to its carcinogenity.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D002273:Carcinogens; D000939:Epitopes; D007536:Isomerism; D008099:Liver / Q000187:drug effects* / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology; D008297:Male; D011233:Precipitin Tests; D051381:Rats; D012995:Solubility; D013997:Time Factors; D010128:p-Aminoazobenzene / Q000031:analogs & derivatives; D004124:p-Dimethylaminoazobenzene / Q000276:immunology*
D000941:Antigens; D002273:Carcinogens; D000939:Epitopes; D010128:p-Aminoazobenzene; D004124:p-Dimethylaminoazobenzene
K otsenke izmeneniĭ antigennoĭ struktury pecheni krys posle odonkratnogo kantserogennogo vozdeĭstviia.