Sclerodermatous graft-versus-host disease limited to an area of measles exanthem.
A female patient with severe idiopathic aplastic anaemia received a successful bone-marrow transplant from her HLA-identical, mixed-lymphocyte-culture-compatible, brother. 8 months after transplantation she had localised cutaneous measles. Chronic sclerodermatous changes developed which were indistinguishable from chronic graft-versus-host disease and were limited to the areas of the original exanthem. Interaction between viral infection and minor histocompatibility differences probably resulted in graft-versus-host disease in this patient.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D005260:Female; D006087:Graft vs Host Reaction; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D011183:Postoperative Complications / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology*; D012867:Skin / Q000276:immunology; D014185:Transplantation, Isogeneic