Survival of heart allografts in rats treated with azathioprine and sodium salicylate.
In a rat heart transplant model representing a severe mismatch, median survival time (M.S.T.) with no treatment was 6 days. M.S.T. with azathioprine was 6 days, and with azathioprine and methylprednisolone 7 days. Azathioprine with promethazine hydrochloride gave an M.S.T. of 15 days. In rats treated with sodium salicylate alone M.S.T. was 16 days, and when azathioprine was administered for 12 days in a group continuously treated with sodium salicylate, all hearts were beating normally at 50 days.
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011398:Promethazine / Q000627:therapeutic use; D051381:Rats; D012980:Sodium Salicylate / Q000627:therapeutic use*; D013997:Time Factors; D014184:Transplantation, Homologous
D011398:Promethazine; D001379:Azathioprine; D012980:Sodium Salicylate; D008775:Methylprednisolone