[7 alpha-Hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in normal and hyperplastic human prostate].
Incubation of 4-14C-5 alpha-androstane-3 beta, 17 beta-diol with human normal and hyperplastic prostate minces led to the NADPH-dependent production of a major polar radiometabolite which was identified as 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol and proved the presence of a 3 beta-hydroxysteroid-7 alpha-hydroxylase in prostate. Such evidences may bring new leads for the study of the mechanisms of androgenic steroid action in the prostate gland.
D015113:Androstane-3,17-diol / Q000378:metabolism*; D000731:Androstanes / Q000378:metabolism*; D006801:Humans; D008297:Male; D009249:NADP; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D013250:Steroid Hydroxylases / Q000378:metabolism*
D000731:Androstanes; D015113:Androstane-3,17-diol; D009249:NADP; D013250:Steroid Hydroxylases
7 alpha-Hydroxylation du 5 alpha-androstane-3 beta, 17 beta-diol dans la prostate humaine normale et hyperplasique.