Human fibroblasts produce "pregnancy-specific" beta-1 glycoprotein in vitro.
Normal and genetic variant strains of nonmalignant human fibroblasts produce in vitro a substance indistinguishable from the recently described "pregnancy-specific" beta-1 glycoprotein (PSbetaG, PAPP-C, SP1). Demonstration of this presumed placenta-specific material in a nonplacental site raises questions about its normal physiologic role and use as a cancer marker.
D001609:Beta-Globulins / Q000096:biosynthesis*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism*; D014644:Genetic Variation; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D011863:Radioimmunoassay / Q000379:methods
D001609:Beta-Globulins; D006023:Glycoproteins