title: Characterization of virus-free guinea pig tumors induced by Kirsten sarcoma virus.
abstract: Tumors were induced by Kirsten sarcoma virus (KiSV) in an inbred guinea pig, strain 13. The tumor cells were established in culture and characterized. The KiSV-induced sarcoma cells were virus-free and nonproducing; however, they contained resuable sarcoma genome. A type B guinea pig retravirus was readily activated from the tumor cells after induction with 5-bromodeoxyuridine (BUDR). BUDR induction of guinea pig retravirus was further enhanced by treatment with dexamethasone, a synthetic glucocorticoid hormone.
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D005796:Genes; D006168:Guinea Pigs; D006378:Helper Viruses; D012194:RNA-Directed DNA Polymerase / Q000096:biosynthesis; D009053:Sarcoma Viruses, Murine; D012513:Sarcoma, Experimental / Q000201:enzymology / Q000209:etiology* / Q000382:microbiology
chemical_list: D000956:Antigens, Viral; D012194:RNA-Directed DNA Polymerase; D001973:Bromodeoxyuridine