title: The effect of intravenous injection of ethyl palmitate emulsion on sequestration of thermally damaged erythrocytes in rats with experimentally induced hypersplenism, and in normal rats.
abstract: The authors attempted at experimental elimination of sequestration function of the spleen in Wistar rats using an i.v. injection of ethyl palmitate emulsion, both in "hypersplenic" animals being long-term applied i.p. methyl cellulose solution, and in control rats. In the rats clearance of 51Cr-labelled and thermally damaged erythrocytes from blood was examined and their sequestration in the spleen and liver followed. The ethyl palmitate injection resulted in both experimental groups in a significant decrease of the erythrocyte counts sequestrated in the spleen, and significant prolongation of the elimination half time for thermally damaged erythrocytes from the blood.
mesh_terms: D000818:Animals; D004905:Erythrocyte Aging / Q000187:drug effects*; D004912:Erythrocytes / Q000502:physiology; D006358:Hot Temperature; D006971:Hypersplenism / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010168:Palmitates / Q000494:pharmacology*; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000502:physiology
chemical_list: D010168:Palmitates; D010169:Palmitic Acids