Regulatory substances produced by lymphocytes--VII. IDS (inhibitor of DNA synthesis) inhibits stimulated lymphocyte proliferation by activation of membrane adenylate cyclase at a restriction point in late G1.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D000242:Cyclic AMP / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis*; D004789:Enzyme Activation / Q000187:drug effects; D006023:Glycoproteins / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D007399:Interphase; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000201:enzymology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D051381:Rats
D006023:Glycoproteins; D007093:Imidazoles; D004247:DNA; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D015056:1-Methyl-3-isobutylxanthine