[Course of the rheumatic process in mitral heart defects after primary and repeated courses of treatment with titrated gamma-globulin].
Titrated gamma-globulin, which the authors used in the preoperative management of patients with acquired valvular disease and minimum rheumatism activity, contained high titers of antibodies against the antigens of streptococcus (streptokinase, streptohyaluronidase, streptolysin 0) and Coxsackie A13, A18, and B3 viruses. Its use in combination with antirheumatic agents did not cause any complications and made it possible to reduce the activity of the process in most cases with grade I and after repeated courses also in grade II activity of rheumatism. Treatment with titrated gamma-globulin stimulates the organism's defence forces (factors of nonspecific immunity: complement, lysozyme, interferon) and leads to diminution of the isolation of cardiotropic viruses from blood and bioptic material of the atria of patients.
D000328:Adult; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000188:drug therapy*; D011300:Preoperative Care; D012214:Rheumatic Heart Disease / Q000188:drug therapy*; D013997:Time Factors; D005719:gamma-Globulins / Q000008:administration & dosage*
D005719:gamma-Globulins
Techenie revmaticheskogo protsessa u bol'nykh mitral'nymi porokami serdtsa posle pervichnykh i povtornykh kursov lecheniia titrovannym gamma-globulinom.