[Effects of TSH on thyroid ribonucleic acids (author's transl)].
Bovine thyroid slices were incubated with TSH (20 mU/ml) in the presence of 0.04 microgram/ml actinomycin D. The incorporation of 3H Adenosine or 3H Uridine in the microsomal RNA fraction was studied. TSH enhanced the labeling of this RNA. After gel electrophoresis in 100% formamide, the distribution of the radioactivity showed a relatively larger incorporation of the precursors in the region corresponding to heavy molecular weight RNA (3 X 10(6) daltons). These data suggest that TSH could exert a specific effect on transcription in the thyroid gland.
D000818:Animals; D002417:Cattle; D003609:Dactinomycin / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology*
D012333:RNA, Messenger; D003609:Dactinomycin; D013972:Thyrotropin
Effets de la TSH sur les acides ribonucléiques thyroidiens.