Inhibiton of Fc-rosette formation by serum of patients with renal allograft rejection.
A test which measures the inhibition of Fc-rosette formation by the patient's serum was used in a group of 23 renal allograft recipients. All 13 serum samples obtained during acute rejection and 2 of 3 obtained during chronic rejection showed strong inhibitory activity, suggesting that the test is of value in confirming the presence of rejection. Its value as a predictive test remains to be established. Preliminary experiments suggest that both immune complexes and alloantibodies contribute to the observed inhibition of Fc-rosette formation.
D000208:Acute Disease; D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody; D002908:Chronic Disease; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007158:Immunologic Techniques; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D007962:Leukocytes / Q000276:immunology; D008297:Male; D014184:Transplantation, Homologous
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G