Impairment of acute protein reactivity in chronic renal failure.
The acute phase protein response was studied after elective surgery in 13 normal subjects and 9 patients with severe  chronic renal failure. Total haemolytic complement reactivity (CH50) and serum concentrations of C1q, C1s, C4, C3, factor B, properdin, C5, C9, C-reactive protein (CRP), caeruloplasmin, alpha1-acid glycoprotein and haptoglobin were measured preoperatively and on days 2, 4 and 6 after operation. Abnormalities were seen in the group with chronic renal failure. Firstly, there was no significant acute phase response of C1s, C3, C5, C9 and CH50 and a significant reduction in the response of factor B. Secondly, CRP showed prolonged elevation in the post-operative period in contrast to the transient rise seen in the control group. With the possible exception of alpha1-acid glycoprotein, the behaviour of the non-complement proteins (caeruloplasmin and haptoglobin) was comparable for the two groups. These defects could impair the physiological response to infection in patients with severe chronic renal failure.
D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D003172:Complement C1 / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003186:Complement C9 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis
D000510:Alpha-Globulins; D003172:Complement C1; D003176:Complement C3; D003182:Complement C5; D003186:Complement C9; D006242:Haptoglobins; D009961:Orosomucoid; D003165:Complement System Proteins; D002097:C-Reactive Protein; D002570:Ceruloplasmin