Cerebrospinal fluid markers in central nervous system metastases from testicular carcinoma.
Serum values of alpha-fetoprotein (AFP) and human chorionic gonadotrophin (HCG) have been used to monitor disseminated testicular carcinoma. Serial measurements of these markers have been used to monitor the response to therapy, to follow the progress of disease, and to detect subclinical recurrences. With increasingly effective chemotherapy for systemic disease, central nervous system (CNS) metastases in testicular carcinoma are becoming increasingly important as a cause of treatment failure. Cerebrospinal fluid (CSF) values of AFP and HCG seem to be important ancillary acids in the neurosurgical management of CNS metastases from testicular cancer. Our preliminary experience with three cases suggests that these CSF markers (plus computerized tomograhic scanning) should be evaluated in patients with this disease.
D000328:Adult; D001927:Brain Diseases / Q000134:cerebrospinal fluid*; D002277:Carcinoma / Q000134:cerebrospinal fluid*; D002822:Choriocarcinoma / Q000134:cerebrospinal fluid*; D006063:Chorionic Gonadotropin / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D013724:Teratoma / Q000134:cerebrospinal fluid*; D013736:Testicular Neoplasms / Q000134:cerebrospinal fluid*; D000509:alpha-Fetoproteins / Q000134:cerebrospinal fluid
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins