[The effect of pesticide combinations on laboratory rats. I. Determination of the acute oral toxicity (LD50) of pesticide combinations].
The growing use of a diversity of pesticides in agricultural practice calls for studies into the toxicity of pesticides when used in combinations. Fundamental studies were conducted into the acute toxicity of pesticide combinations in rat and showed that double or triple combinations of parathion-methyl, carbaryl, and Lindan could aggravate or mitigate toxicity, depending on the active ingredients involved. The above findings were obtained from acute animal experiments, but it may well be necessary to develop proper screening models for optimum information and to study subchronic toxicity as well.
D000818:Animals; D012721:Carbaryl / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D001556:Hexachlorocyclohexane / Q000633:toxicity; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008743:Methyl Parathion / Q000633:toxicity; D051381:Rats
D007306:Insecticides; D008743:Methyl Parathion; D001556:Hexachlorocyclohexane; D012721:Carbaryl
Untersuchungen zur Wirkung von Pestizidkombinationen auf die Laboratoriumsratte. 1. Mitteilung: Bestimmung der akuten oralen Toxizität (DL50) von Pestizidkombinationen.