[Impairment of rapid axonal transport and concomitant anomaly of smooth endoplasmic reticulum in acrylamide induced neuropathy].
The axonal transport of proteins was studied by radioautography in preganglionic axons of ciliary ganglia in Leghorn chickens treated by acrylamide. The slow axonal transport of proteins was hardly affected. In contrast, the fast axonal transport was severely impaired. Indeed, radioactive proteins accumulated focally at the periphery of several preterminal axons in regions showing a local disorganization of the smooth endoplasmic reticulum which seemed to be one of the earliest changes induced by acrylamide.
D000178:Acrylamides; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D001369:Axons / Q000187:drug effects / Q000503:physiopathology* / Q000648:ultrastructure; D002645:Chickens; D002924:Ciliary Body / Q000294:innervation*; D004721:Endoplasmic Reticulum / Q000187:drug effects*; D005725:Ganglia, Autonomic / Q000503:physiopathology*; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009498:Neurotoxins; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects
D000178:Acrylamides; D009419:Nerve Tissue Proteins; D009498:Neurotoxins
Altération du transport axonal rapide et anomalie concomitante du reticulum endoplasmique lisse dans la neuropathie à l'acrylamide.