[Effect of diiodobenzotefa on the functionally different subpopulations of T-lymphocytes].
Diiodobenzo-tepa (DIB) was given orally to CBA mice in a dose of 25 mg/kg for 3 successive days. The number of nucleus-containing cells decreased 3.9 fold in the thymus and 1.4 fold in the bone marrow. In experiments on transplantation of lymphoid cells to intact or lethally irradiated (CBA X C57BL/6J)F1 mice treated with DIB this substance did not influence the helper activity of T lymphocytes but inhibited the activity or B and T lymphocytes, inducing "graft-versus-host" and T cell-suppressor functions.
D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology*; D001389:Azirines / Q000494:pharmacology*; D001854:Bone Marrow Cells; D007958:Leukocyte Count; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology; D013721:Triethylenephosphoramide / Q000031:analogs & derivatives / Q000494:pharmacology*
D001389:Azirines; D013721:Triethylenephosphoramide
Deĭstvie diiodbenzotéfa na funktsional'no razlichnye subpopuliatsii T-limfotsitov.