[Vaccine from the cell fragments of Bordetella pertussis. I. Protective, sensitizing properties and morphological characteristics of the vaccine].
The authors present the results of studying the protective and sensitizing properties of a new preparation made of a ultrasonic disintegrate of pertussis microbes treated by ethyl ether. As shown by electron microscopy, the preparation consisted of the cell wall elements (the membrane), remnants of the cytoplasm and protectosome, i.e. it represented a vaccine consisting of cell fragments. In crude and sorbed condition it possessed marked protective properties (a test on mice). The content of protective units in the adsorbed preparation increased 1.5-3 times. The vaccine produced no sensitizing action, and its histamine-sensitizing activity was 3-5 times lower by protein and 5-10 times--by IOU than that of the whole-cell vaccine prepared form the same microbial suspension.
D000818:Animals; D001886:Bordetella pertussis / Q000166:cytology* / Q000276:immunology; D002473:Cell Wall / Q000276:immunology; D005069:Evaluation Studies as Topic; D006636:Histamine Release; D051379:Mice; D010567:Pertussis Vaccine; D013010:Sonication; D014917:Whooping Cough / Q000517:prevention & control
D010567:Pertussis Vaccine
Vaktsina iz kletochnykh fragmentov Bordetella pertussis. Soobshchenie I. Zashchitnye, sensibiliziruiushche svoĭstva i morfologicheskaia kharacteristika vaktsiny