Effect of bleomycin on peripheral lymphocytes.
Five patients with carcinoma of the penis receiving radiation therapy and injections of Bleomycin were examined to determine whether Bleomycin affects the peripheral pool of lymphoid cells. Total lymphocyte counts were not decreased, but transient reduction of the frequency of thymus-dependent cells occurred in 3 patients. The responses of the lymphocytes to phytomitogens and PPD were temporarily decreased these 3 patients. In 2 subjects the phytomitogen reactivity of the lymphocytes was improved after treatment.
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use; D002478:Cells, Cultured; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy
D008934:Mitogens; D001761:Bleomycin