Inhibitor of in-vitro granulopoiesis in plasma of patients with renal failure.
Plasmas from 31 patients with moderately severe to severe renal failure inhibited granulopoietic colony formation in human marrow in vitro. The inhibitory activity could not be removed by in-vitro dialysis but was present in an ultrafiltered fraction of molecular weight less than 25 000 daltons. It inhibited the production of colony-stimulating activity (C.S.A.) by leucocytes in the culture system but had little or no effect on preformed C.S.A. or on the granulopoietic colony-forming cell itself. The level of plasma inhibitory activity correlated with the degree of azotaemia but not with the neutrophil or monocyte counts. Despite the potency with which granulopoiesis was inhibited in vitro, none of the patients was severely neutropenic, and only 4 had mild neutropenia (neutrophil count 1.5--2.1 x 10(9)/1).
D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002999:Clone Cells / Q000473:pathology; D003114:Colony-Forming Units Assay; D003404:Creatinine / Q000097:blood; D006131:Growth Inhibitors / Q000494:pharmacology; D006410:Hematopoiesis; D006801:Humans; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000097:blood*; D007958:Leukocyte Count; D009504:Neutrophils / Q000473:pathology*; D006435:Renal Dialysis
D006131:Growth Inhibitors; D003404:Creatinine