Persistence of drug-resistant malaria parasites.
Mixtures of drug-resistant and sensitive forms of Plasmodium chabaudi were used to infect mice, and the resulting infections were maintained in the absence of drug. Both chloroquine-resistant and pyrimethamine-resistant mutans were able to survive in such mixed infections. The results of experiments on chloroquine resistance indicated an apparent selective advantage of the resistant over the sensitive form.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D009154:Mutation; D010961:Plasmodium / Q000187:drug effects* / Q000235:genetics; D011739:Pyrimethamine / Q000494:pharmacology / Q000627:therapeutic use*
D002738:Chloroquine; D011739:Pyrimethamine