Transformation of normal bone-marrow cells by a leukaemic cell line associated with a presumptive new human virus.
Intracytoplasmic leukovirus-like bodies were found in the cells and culture medium of a T-cell lymphoblast line established from a leukaemic patient. When the cells were lethally irradiated and added to normal bone-marrow cells the latter were transformed into continuous replication and produced the same types of virus-like particle.
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002472:Cell Transformation, Viral; D005260:Female; D006056:Golgi Apparatus / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D007181:Inclusion Bodies, Viral; D007948:Leukemia, Monocytic, Acute / Q000473:pathology* / Q000635:transmission; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011829:Radiation Dosage; D012190:Retroviridae / Q000302:isolation & purification*; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology* / Q000528:radiation effects