Inhibition of platelet aggregation during hypovolemic hypotension by acetylsalicylic acid and artificial respiration.
In vivo measurement of platelet aggregation was performed by a previously described photoelectric method. It is shown that platelet aggregation induced by arterial hypotension can be inhibited by i.v. administration of ASA and by artificial respiration. The inhibition of platelet aggregation following artificial ventilation is significantly more pronounced than by ASA given 24 h prior to the beginning of the experiments. Different sources of platelet aggregation in venous and arterial blood are informative about the canine lung not only as a filter for aggregates but also as a source of aggregating substances.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004285:Dogs; D006636:Histamine Release; D007022:Hypotension / Q000097:blood / Q000150:complications*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000378:metabolism; D012121:Respiration, Artificial; D012701:Serotonin / Q000378:metabolism; D012769:Shock / Q000097:blood / Q000150:complications*
D011453:Prostaglandins; D012701:Serotonin; D000244:Adenosine Diphosphate; D001241:Aspirin