Altered vitamin-D metabolism in pregnancy.
Low levels of plasma-25-hydroxy-vitamin-D (25-OHD) (less than 16 nmol/1) were found in 33% of a group of pregnant women studied in South London. Non-White women in the last 10 weeks of pregnancy had significantly reduced levels compared with non-pregnant controls (P less than 0.02). Plasma-25-OHD was unrelated to dietary vitamin-D intake, age, parity, social class, plasma-calcium, and plasma-albumin. Reduction of plasma-25-OHD could contribute to the fall in plasma-calcium during pregnancy, and may result from enhanced maternal metabolism or increased utilisation of vitamin D by the fetus.
D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood / Q000378:metabolism*; D006996:Hypocalcemia / Q000209:etiology; D010710:Phosphates / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000378:metabolism*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D044469:Racial Groups; D012709:Serum Albumin / Q000032:analysis; D014807:Vitamin D / Q000008:administration & dosage; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications
D006454:Hemoglobins; D006887:Hydroxycholecalciferols; D010710:Phosphates; D012709:Serum Albumin; D014807:Vitamin D; D000469:Alkaline Phosphatase; D002118:Calcium