Antigenic relationships of alphaviruses by a simple micro-culture cross-neutralization method.
A cross-neutralization study of 22 alphaviruses disclosed two major antigenic complexes and two viruses that were distinct from all the others. Cross-reactions were common but were restricted within the complexes. Sub-groupings within a complex were also shown, and some viruses proved to be indistinguishable by neutralization testing. The results generally paralleled previously reported data. Investigations were carried out, using BHK 2I cells in a micro tissue-culture system, on all available alphaviruses.
D000956:Antigens, Viral / Q000032:analysis*; D001103:Arboviruses / Q000145:classification / Q000276:immunology*; D002460:Cell Line; D003429:Cross Reactions; D000939:Epitopes; D009500:Neutralization Tests
D000956:Antigens, Viral; D000939:Epitopes