Modulation of plasma 1,25-dihydroxyvitamin D in man by stimulation and suppression tests.
In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) levels by 80% (peak 8--40 h after infusion) without producing any significant change in plasma calcium, phosphate, or magnesium. An oral calcium load suppressed plasma 1,25-(OH)2D to 63% of control values within 48--72 h. These responses will be useful in the diagnosis and management of disturbances of calcium and mineral metabolism in which vitamin D metabolism is abnormal.
D000284:Administration, Oral; D002118:Calcium / Q000008:administration & dosage; D002128:Calcium Metabolism Disorders / Q000175:diagnosis; D004100:Dihydroxycholecalciferols / Q000037:antagonists & inhibitors / Q000097:blood*; D006728:Hormones; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D007263:Infusions, Parenteral; D010281:Parathyroid Hormone / Q000008:administration & dosage
D004100:Dihydroxycholecalciferols; D006728:Hormones; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002118:Calcium