Intermediate filaments in hyaline material in alcoholic liver disease (Mallory bodies) and in cultured hepatoma cells.
Antibodies specific for cytoskeletal intermediate (10 nm) filaments reacted both with the hyaline deposits in alcoholic liver disease (Mallory bodies) and with perinuclear hyaline material of cultured hepatoma cells used as a model for hyaline formation in vitro. Our results suggest that disorganization and accumulation of intermediate filaments is an important step in the pathogenesis of alcoholic liver injury.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D046508:Culture Techniques; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006801:Humans; D006818:Hyalin; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D051381:Rats