Iron absorption in iron-loading anaemias: Effect of subcutaneous desferrioxamine infusions.
Absorption of 59Fe ferrous sulphate was measured in patients with a variety of iron-loading anaemias both before and during subcutaneous infusions of desferrioxamine. The infusions were associated with a reduction in absorption (P less than 0-025). This effect was not altered by saturation with ascorbic acid.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000378:metabolism*; D000756:Anemia, Sideroblastic / Q000151:congenital / Q000378:metabolism*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D001665:Binding Sites; D001803:Blood Transfusion; D003676:Deferoxamine / Q000008:administration & dosage* / Q000627:therapeutic use; D004357:Drug Synergism; D004912:Erythrocytes / Q000473:pathology; D005260:Female; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D007504:Iron Radioisotopes; D007553:Isotope Labeling; D008297:Male; D013789:Thalassemia / Q000378:metabolism*
D005296:Ferrous Compounds; D007504:Iron Radioisotopes; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine; D001205:Ascorbic Acid