Chemotherapy in the treatment of osteogenic sarcoma of the maxilla (case report).
A case of osteogenic sarcoma of the maxilla is described. The tumor was excised by a hemimaxillectomy but recurred in 3 months. The patient died 8 months after the initial onset of symptoms. Chemotherapy and radiation were ineffective with the exception of bleomycin, which caused necrosis of the tumour, with no apparent increase in growth, and a decrease of the serum alkaline phosphatase level to less than half of the maximum value. There was a close correlation between the fluctuating pattern of the serum alkaline phosphatase level and the growth and remission of the tumour during the entire course of treatment.
D000469:Alkaline Phosphatase / Q000097:blood; D001761:Bleomycin / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008441:Maxillary Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D015122:Mercaptopurine / Q000627:therapeutic use*; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000188:drug therapy* / Q000201:enzymology; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use*
D008937:Mitomycins; D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D015122:Mercaptopurine; D000469:Alkaline Phosphatase