[Rhythmicity in the structure-functional changes in hepatocytes following exposure to pesticides].
The processes of dursban biotransformation during the liver perfusion in rats exposed to CCl4 and milbex for 4, 8 and 15 days (microsomal enzyme inhibitor and inducer, respectively) were studied. The ultrastructure of hepatocytes was examined in the animals treated with the mentioned poisons. Three stages of the structural and functional changes were revealed. Reconstruction of the dursban biotransformation ways occurred from the 8th day, i.e. the dialkylation processes were intensified, resulting in production of less toxic metabolites.
D000435:Alcoholic Intoxication; D000818:Animals; D001391:Azo Compounds / Q000506:poisoning; D001711:Biotransformation; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004390:Chlorpyrifos / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004790:Enzyme Induction; D000431:Ethanol / Q000031:analogs & derivatives; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats
D001391:Azo Compounds; D007306:Insecticides; D000431:Ethanol; D010088:Oxidoreductases; D004390:Chlorpyrifos
Ritmichnost' strukturno-funktsional'nykh izmeneniĭ gepatotsitov pri vozdeĭstvii pestitsidov