[TRH-test in hyperthyreoidism. Investigations of the TRH stimulated TSH-secretion in anti-thyroid drug treated primary hyperthyreoidism and in experimentally induced hyperthyreoidism (author's transl)].
Determinations in 11 patients with anti-thyroid drug therapy of hyperthyreoidism showed, that a pronounced lag period exist between normalisation of thyroid hormone level and TRH responsiveness. The lag period range between 5 and 27 weeks. During this time it is not necessary to give simultaneously thyroid hormones in antithyroid drug therapy to compensate hyperresponsiveness of TSH. - Investigations in 12 volunteers with experimental hyperthyreoidism induced by administration of thyroxine suggest a longterm suppression of the hypophysis to be the cause of the lag period of TSH-secretion. There are some similarities to the ACTH-suppression in therapy with corticosteroids and to the so-called "syndrome of oversuppression" in long lasting treatment with contraceptive drugs.
D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
D013956:Antithyroid Agents; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine
TRH-Test im Verlauf von Hyperthyreosen. Untersuchungen über die TRH-stimulierte TSH-Sekretion bei thyreostatisch behandelter primärer Hyperthyreose und Hyperthyreosis factitia