The association of HLA--B8 with atrophic thyroiditis.
One-hundred-and-forty-seven patients with autoimmune thyroiditis were studied with respect to HLA antigens as they related to various clinical features. HLA--B8 was found to be significantly increased among 59 patients with atrophic thyroiditis (57% vs. 26% for controls) but was identical to controls in 88 patients with goitrous thyroiditis (26%). No relation was found in either group between B8 and thyroid autoantibody titer or, in the case of goitrous thyroiditis, the rate of progression of the disease. Thus a link seems to be established between Graves' disease and atrophic thyroiditis in that both are significantly associated with HLA-B8. This study stresses the need to take clinical features into consideration when examining for HLA/disease associations.
D001284:Atrophy; D001327:Autoimmune Diseases; D000939:Epitopes; D006042:Goiter / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D013961:Thyroid Gland / Q000473:pathology; D013966:Thyroiditis / Q000235:genetics / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens