Mimickry of anti-granuloma effect of prostaglandin E by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors.
Local administration of PGE1 to pre-formed inflammatory granulomata of rats results in a decrease of granulomatous tissue and reduction of prostaglandin concentrations in granulomatous exudates. Under the same experimental conditions, a similar correlation between these two effects is observed with dibutyryl cyclic-AMP. An anti-granuloma effect is also achieved with the phosphodiesterase inhibitors, IBMX and RA-233, but not with theophylline, a rather feeble inhibitor of this enzyme. The present findings provide further support for the concept that elevation of cyclic-AMP in cell population(s) within granuloma is a promising line for pharmacological suppression of inflammatory tissue proliferation.
D015056:1-Methyl-3-isobutylxanthine / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents; D003994:Bucladesine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy*; D009012:Mopidamol / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011458:Prostaglandins E / Q000627:therapeutic use*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D010726:Phosphodiesterase Inhibitors; D011458:Prostaglandins E; D009012:Mopidamol; D003994:Bucladesine; D013806:Theophylline; D015056:1-Methyl-3-isobutylxanthine