On the cause of raised serum-amylase in diabetic ketoacidosis.
7 of 13 patients with diabetic ketoacidosis had raised serum-amylase concentrations. Isoenzymes analysis by polyacrylamide-gel electrophoresis showed that salivary-type amylases and not pancreatic-type amylases were responsible for the rise in 6 or the 7 cases. This demonstrates that the pancreas is usually not the origin of the increase in serum-amylase. Since salivary-type amylases are widely distributed in glandular epithelium, it is suggested that hyperamylasaemia in diabetic ketoacidosis is most often caused by systemic derangement of carbohydrate metabolism.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D003404:Creatinine / Q000097:blood; D016883:Diabetic Ketoacidosis / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007527:Isoenzymes / Q000097:blood*; D007651:Keto Acids; D007659:Ketones / Q000097:blood; D008297:Male; D008875:Middle Aged; D010189:Pancreatic Juice / Q000201:enzymology; D012463:Saliva / Q000201:enzymology
D001786:Blood Glucose; D007527:Isoenzymes; D007651:Keto Acids; D007659:Ketones; D002245:Carbon Dioxide; D003404:Creatinine; D000681:Amylases