title: Studies on non-H-2-linked lymphocyte-activating determinants. II. Nonexpression of Mls determinants in a mouse strain with an X-linked B lymphocyte immune defect.
abstract: Minor lymphocyte-stilulating (MIs) coded non-H-2-linked lymphocyte-activating determinants (LADs) are present on a late developing subpopulation of murine B lymphocytes. Spleen cells derived from CBA/N mice, a strain with an X-linked defect in B cell function, failed to stimulate a response in MIs-defined mixed lymphocyte reactions (MLRs) with H-2 identical CBA/J or C3H/N responder spleen cells. However, both CBA/J and C3H/N spleen cells induced significant responses in CBA/N responder spleen cells. The inability of CBA/N cells to induce an MIs-defined response was not due to the presence of the nonstimulatory MIsb genotype, since spleen cells of immunologically normal F1 mice derived from crosses of CBA/N and C3H/N mice were stimulatory in MLRs for C3H/N responder cells. Immunologically abnormal CBA/N female x C3H/N male) F1 male mice, which are hemizygous for the CBA/N X chromosome, were also unable to induce a response in MIs-defined MLRs. Although the MIs coded LADs are not X linked in immunologically normal mouse strains, these data indicate that the failure of CBA/N mice to functionally express the MIs-coded LADs is X linked. This characteristic was not secondary to the presence of suppressor cells and is most likely related to the absence of a late developing (mature) subpopulation of B lymphocytes in these mice.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002874:Chromosome Mapping; D000939:Epitopes; D005260:Female; D006649:Histocompatibility Antigens; D007136:Immunoglobulins / Q000032:analysis; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D012730:Sex Chromosomes / Q000276:immunology; D013154:Spleen / Q000166:cytology
chemical_list: D000939:Epitopes; D006649:Histocompatibility Antigens; D007136:Immunoglobulins