Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Five permanent tumor cell lines derived originally from either a solid or an ascites biopsy of rat hepatoma exhibited differential sensitivities to bleomycin, Adriamycin, 1-beta-D-arabinofuranosylcytosine, hydroxyurea, 1-trans-(2)-chloroethyl)-3-(4-methoylcyclohexyl)-1-nitrosourea, and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. The cells were least sensitive to hydroxyurea and 1-beta-D-arabinofurano-sylcytosine, with some cell lines being almost totally resistant to these drugs. However, from 25- to 700-fold differences in survival were obtained between cell lines treated with either bleomycin or Adriamycin.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004351:Drug Resistance; D006918:Hydroxyurea / Q000494:pharmacology; D008113:Liver Neoplasms / Q000188:drug therapy*; D008130:Lomustine / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D012673:Semustine / Q000494:pharmacology
D000970:Antineoplastic Agents; D003561:Cytarabine; D001761:Bleomycin; D012673:Semustine; D008130:Lomustine; D004317:Doxorubicin; D006918:Hydroxyurea