Studies on pyrazine derivatives. Part X. Synthesis and tuberculostatic activity of some 6-cyclamino-, 6-imidazolyl--and triazolylpyrazine-2-carboxylic acids derivatives.
The 6(2'-methylpiperidine-, 2',6'-dimethylmorpholino-, imidazolyl- and triazolyl)-2-cyanopyrazines were prepared from 2-cyano-6-chloropyrazine. The -CN group was then transformed into COOH, CONH2, CSNH2, CONHNH2, CONHOH and C(NOH)NH2 functions. All compounds obtained were of weak tuberculostatic activity. Comp. 13 was active against isoniazide, capreomycin and ethionamide resistent strains at the concentration range of 31.2--62.5 microgram/cm3.
D000995:Antitubercular Agents; D002207:Capreomycin / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D004352:Drug Resistance, Microbial; D005000:Ethionamide / Q000627:therapeutic use; D007093:Imidazoles / Q000627:therapeutic use; D007538:Isoniazid / Q000627:therapeutic use; D009161:Mycobacterium / Q000187:drug effects; D011719:Pyrazines / Q000138:chemical synthesis / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy
D000995:Antitubercular Agents; D007093:Imidazoles; D011719:Pyrazines; D014230:Triazoles; D002207:Capreomycin; D005000:Ethionamide; D007538:Isoniazid