Prevention of tolerance in differentiating B lymphocytes by T cells.
Normal, but not tolerant, adult thymocytes prevented particulate antigen inducing tolerance in differentiating B lymphocytes. This was demonstrated by measuring the emergence of responsive B cells (identified by their allotype) developing from a foetal liver innoculum in irradiated hosts with or without the addition of antigen, thymocytes or tolerant thymocytes. The relevance of these findings to the recruitment of B lymphocytes in adult animals and to the development of those autoreactive B cells found in normal animals is discussed.
D000818:Animals; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D004136:Dinitrobenzenes / Q000276:immunology; D007108:Immune Tolerance; D008099:Liver / Q000166:cytology / Q000196:embryology; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014185:Transplantation, Isogeneic; D005719:gamma-Globulins / Q000276:immunology
D000941:Antigens; D004136:Dinitrobenzenes; D005719:gamma-Globulins