title: Free-radical oxidation and antioxidants.
abstract: Cells and tissues are protected against oxidising free radicals by a complexity of antioxidant mechanisms. In disease these mechanisms may fail; or the mechanisms may fail and cause disease. The primary products of free-radical oxidation undergo rapid and spontaneous fragmentation. Many of these fragments are highly active in biological systems. Some may have considerable survival value. Others are potentially lethal.
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism; D014131:Trace Elements / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D014131:Trace Elements; D014168:Transferrin; D014810:Vitamin E; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D001205:Ascorbic Acid