Plasma levels of 8-methoxypsoralen and phototoxicity studies during PUVA treatment of psoriasis with meladinin tablets.
A new tablet formulation of 8-methoxypsoralen was used in PUVA treatment for psoriasis. The 8-Mop plasma level showed a maximum at about 1 hour after ingestion (mean values: 1/2 hr, 284 microgram/1; 1 hr, 275 microgram/1; 1 1/2 hr, 198 microgram/1; 2 hrs, 129 microgram/1). Phototoxicity tests showed the optimal time for exposure to be about 1 hour after peroral intake of 8-MOP.
D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D008875:Middle Aged; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy*; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D008730:Methoxsalen