Demonstration of chicken fetal antigen (CFA) on normal splenic lymphocytes, Marek's disease lymphoblastoid cell lines and other neoplasms.
Chicken fetal antigen (CFA) was detected on normal splenic lymphocytes and a direct relationship was observed between the percentage of CFA-positive cells and the age of the donor. The fetal antigen was also detected on lymphoblastoid tumor cells and cell lines induced by known avian oncogenic viruses (Marek's disease virus and avian leukosis virus), and on spontaneously occurring adenocarcinoma cells. The fetal antigen appears to be distinct from Marek's disease tumor-associated surface antigen.
D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D001353:Avian Leukosis / Q000276:immunology*; D002460:Cell Line; D002642:Chick Embryo; D002645:Chickens; D000939:Epitopes; D005260:Female; D006824:Hybridization, Genetic; D008214:Lymphocytes / Q000276:immunology*; D008380:Marek Disease / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology*; D011784:Quail; D013154:Spleen / Q000166:cytology / Q000276:immunology
D000951:Antigens, Neoplasm; D000939:Epitopes