Idiotype-specific transplantation resistance to MOPC-315: abrogation by post-immunization thymectomy.
The idiotype-specific myeloma transplantation resistance induced in BALB/c mice by immunization with the DNP-binding IgAlambda2 protein produced by plasmacytoma MOPC-315 is ablated by post-immunization thymectomy. Sham-thymectomy has no effect. The ablative effect of thymectomy is observed is observed in mice challenged subcutaneously with MOPC-315 cells either 3 days after thymectomy, or after a rest period of 44 days after thymectomy. These observations suggest that short-lived, thymic-dependent suppressive factors may play a role in the idiotype-specific myeloma graft resistance.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D000939:Epitopes; D005838:Genotype; D007114:Immunization; D007279:Injections, Subcutaneous; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000209:etiology*; D013934:Thymectomy; D013997:Time Factors
D000939:Epitopes