T-lymphocyte differentiation antigens shared by humans and rhesus monkeys.
Anti-human T-lymphocyte serum (anti-HTLA) was used to investigate the relationship between differentiation antigens of human (HTLA) and Macaca lymphocytes. The percentage of lymphocytes sensitive to anti-HTLA is the same in both species, with thymocytes having a higher concentration of HTLA than more mature T-lymphocytes. Macaca bone marrow cells acquire phenotypic properties of T-lymphocytes in vitro in the presence of calf thymic factors. Our data suggest that phylogenetic distinctions between various T-lymphocyte differentiation antigens may be utilized to provide antisera of narrow specificity.
D000818:Animals; D000961:Antilymphocyte Serum / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D000939:Epitopes; D000882:Haplorhini; D006801:Humans; D008251:Macaca; D008253:Macaca mulatta; D010802:Phylogeny; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D000939:Epitopes