Virus-like structures in lupus erythematosus discoides.
Biopsy specimens from typical skin lesions of DLE patients were studied by means of electron microscopy. Virus-like structures were discovered in the cytoplasm of fibrocytes, endothelial cells and keratinocytes. After prolonged chloroquine treatment a decrease in the frequency and size of these structures was observed.
D002738:Chloroquine / Q000627:therapeutic use; D003593:Cytoplasm / Q000382:microbiology; D005260:Female; D006801:Humans; D007181:Inclusion Bodies, Viral; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D012867:Skin / Q000382:microbiology*
D002738:Chloroquine