Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis.
Incubation of human leukocytes with certain viruses results in the enhancement of IgE-mediated release of histamine. This enhancement is produced by interferon. The present experiments show that an induction period of 6 to 9 hr and new RNA synthesis are required for interferon to enhance histamine release. This points to the possibility that interferon may exert its antiviral and histamine-release enhancing activities by acting through a common pathway.
D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D001491:Basophils / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E; D007372:Interferons / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D013997:Time Factors
D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D003609:Dactinomycin; D007073:Immunoglobulin E; D012313:RNA; D007372:Interferons