Controlled storage of biological energy: The role of plasma lipoproteins.
A scheme is advanced whereby plasma-lipoproteins form an integrated controlled pathway for storage of energy as triglyceride. The importance of insulin within this system is indicated and the consequence of possible errors considered. Changes secondary to organ disease are found to fit within the proposed pathway. Although many refinements remain to be added, this hypothesis seems to form a plausible framework within which lipoprotein abnormality and the underlying condition may be better understood and thereby treated.
D001053:Apolipoproteins / Q000097:blood; D002096:C-Peptide / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002914:Chylomicrons / Q000097:blood; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D007009:Hypolipoproteinemias / Q000378:metabolism; D007328:Insulin / Q000502:physiology; D007674:Kidney Diseases / Q000378:metabolism; D007863:Lecithin Cholesterol Acyltransferase Deficiency / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000172:deficiency; D008074:Lipoproteins / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D001053:Apolipoproteins; D002096:C-Peptide; D002914:Chylomicrons; D007328:Insulin; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008071:Lipoprotein Lipase