Teratogenic action and embryo lethality of AY 9944R. Prevention by a hypercholesterolemia-provoking diet.
Embryomortality and teratogenesis provoked by inhibitors of cholesterol synthesis are well demonstrated. Teratogenic action is particularly reflected by holoprosencephalies, but also by uro-genital abnormalities. A hypercholesterolemia-provoking diet has been shown to be completely effective for preventing holoprosencephaly, but only partially so for preventing the uro-genital malformations and fetal mortality. It is thus possible that the two types of abnormalities are governed by different mechanisms. In addition, the diet itself, whose hypercholesterolemic effect is considerable, has certain disadvantages. It seems to have a certain effect on fetal mortality and could be responsible for several uro-genital malformations. This deserves further study.
D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D001921:Brain / Q000002:abnormalities; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary; D003510:Cyclohexanes / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D006937:Hypercholesterolemia / Q000209:etiology; D008297:Male; D011247:Pregnancy; D051381:Rats; D014564:Urogenital Abnormalities; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride / Q000633:toxicity*
D002791:Cholesterol, Dietary; D003510:Cyclohexanes; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; D002784:Cholesterol