[The influence of 6-mercaptopurine on the humoral immune response in guinea pig. 2. The influence on formation of complement binding antibodies (author's transl)].
The effectivity of treatment with 10 mg 6-mercaptopurine/kg/day--beginning on the day of antigen injection and continuing for seven days--on the synthesis of complement binding antibodies is very different. The formation of gamma-2-antibodies against BGG was nearly complete suppressed, an influence on the anti-DNP-gamma-2-antibody formation was not detectable and the antibody formation against HSA was enhanced. The results suggest that the kind of antigen is very important for the immunosuppressive activity of 6-mercaptopurine in guinea pigs.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D000941:Antigens; D002417:Cattle; D003168:Complement Fixation Tests; D004912:Erythrocytes / Q000276:immunology; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006801:Humans; D007165:Immunosuppression Therapy; D015122:Mercaptopurine / Q000494:pharmacology*; D012709:Serum Albumin / Q000276:immunology; D012756:Sheep; D005719:gamma-Globulins
D000941:Antigens; D012709:Serum Albumin; D005719:gamma-Globulins; D005620:Freund's Adjuvant; D015122:Mercaptopurine
Der Einfluss von 6-Merkaptopurin auf die humorale Immunantwort des Meerschweinchens. 2. Die Beeinflussung komplementbindender Antikörper.