Sensitivity of human lymphocytes to bleomycin increases with age.
The sensitivity of human peripheral blood lymphocytes to bleomycin and mitomycin-C was assessed by measuring the inhibition of phytohemagglutinin stimulated proliferation. The sensitivity to bleomycin, and not to mitomycin-C, increased with the age.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001761:Bleomycin / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D008875:Middle Aged; D008937:Mitomycins / Q000494:pharmacology
D008937:Mitomycins; D001761:Bleomycin