Human schistosomiasis: Schistosoma mansoni antigen detection in renal glomeruli.
Twelve kidney, five biopsy and seven necropsy specimens, all from schistosomiasis mansoni patients were studied by light and immunoflurescent microscopy in an attempt to detect antigen in the glomerular walls. Deposits of IgM, IgG,I gA, IgE, complement C3 and fibrinogen were observered in most cases. Antigen was successfully detected in two cases(one biopsy and one necropsy specimen), both exhibiting proliferative glomerulonephritis. The only clinical manifestation was a slight proteinuria. IgG antibodies eluted from the sutopsy kidney homogenates showed specific binding mostly to Schistosoma mansoni gut, thus spggesting that the fixed antibodies (eluates) are, at least partially, consituted by antibodies similar to the anti-circulating antigen. These data reinfroce the hypothesis that renal injury in schistosomiasis is mediated through an immune complex disease.
D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000032:analysis; D002648:Child; D000939:Epitopes; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology* / Q000469:parasitology; D008297:Male; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology*
D000936:Antigen-Antibody Complex; D000941:Antigens; D000939:Epitopes