Cold pressor test in detection of coronary heart-disease and cardiomyopathy using technetium-99m gated blood-pool imaging.
50 normotensive subjects (22 controls with no cardiac disease, 24 patients with coronary heart-disease, and 4 with early cardiomyopathy) were investigated with gated cardiac blood-pool scintigraphy before and during cold pressor stimulation. The controls had no change or a significant rise (p less than 0.005) in left ventricular ejection fraction and preserved normal myocardial-wall motion, whereas patients with coronary-artery disease or cardiomyopathy had a significant fall (p less than 0.001) in left ventricular ejection fraction and many developed abnormal regional wall motion despite the absence of angina pectoris. Cold pressor gated cardiac blood-pool studies were more sensitive than single-lead exercise electrocardiography (p = 0.03) in the detection of patients with severe coronary-artery disease without previous myocardial infarction.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003080:Cold Temperature; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004912:Erythrocytes; D005069:Evaluation Studies as Topic; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000379:methods*; D013667:Technetium
D013667:Technetium