Continuous lymphoblastoid suspension cultures from cells of haematopoietic organs of baboons with malignant lymphoma. Report III: Immunological studies.
Lymphoblastoid cultures established from haematopoietic organs of baboons with lymphoma belong to the B-cell type. Cytoplasmic antigen is revealed in 2--6% of suspension culture cells established from lymphomatous baboons by indirect immunofluorescence reaction using serum from human Burkitt's lymphoma patients with antibody titer to capsid antigen of Epstein-Barr virus 1: 320. There is a correlation between the number of antigen-containing cells in these cultures and the number of cells in which herpes virus is revealed electron microscopically. Sera of baboons with lymphoma contain high titers of antibodies to Epstein-Barr (EBV) virus. Specific differences between antigens being produced in cultures by HBV (herpes virus of baboon) and EBV (Epstein-Barr virus) are minimal, that indicates their immunologic similarity.
D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification; D002478:Cells, Cultured; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D006413:Hematopoietic System / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D066298:In Vitro Techniques; D008223:Lymphoma / Q000276:immunology*; D010215:Papio; D011947:Receptors, Antigen, B-Cell / Q000302:isolation & purification
D000956:Antigens, Viral; D000939:Epitopes; D011947:Receptors, Antigen, B-Cell