title: Inhibition of pancreas and gallbladder by pancreatic polypeptide.
abstract: Stimulated pancreatic and biliary outputs were studied in seven healthy subjects during intravenous infusion of bovine pancreatic polypeptide (P.P.) (mean dose 65 pmol/kg/h). P.P. significantly inhibited outputs of trypsin and bilirubin at plasma concentrations similar to those observed after meals. In four cholecystectomised subjects, P.P. inhibited only trypsin output.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001639:Bicarbonates / Q000037:antagonists & inhibitors; D001663:Bilirubin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002417:Cattle; D004435:Eating; D005704:Gallbladder / Q000187:drug effects* / Q000503:physiopathology; D006728:Hormones / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors
chemical_list: D001639:Bicarbonates; D006728:Hormones; D014361:Trypsin Inhibitors; D010191:Pancreatic Polypeptide; D014357:Trypsin; D001663:Bilirubin