Matching for DLA-A, DLA-B and DLA-D antigens and skin allograft survival in unrelated beagle dogs.
The effect of matching for immunogenetic markers on the survival of skin allografts in unrelated dogs has been studied. Skin grafts in recipients differing from donors for either DLA-A or DLA-B antigens, or both, had mean survival times (MST) of 9.3, 9.7 and 8.5 days, respectively. Differences between these groups were not significant. Prolonged survival of skin grafts, however, was found in SK-LD-indentical (MST: 12.4 days) or SD-identical/LD-different (MST: 12.5 days) donor-recipient combinations. We conclude that dkin allograft survival in dogs appears to be controlled by DLA-A and DLA-B, but not by DLA-D determinants.
D000818:Animals; D004285:Dogs / Q000276:immunology*; D000939:Epitopes; D006085:Graft Survival; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000939:Epitopes; D006649:Histocompatibility Antigens