Association between leucocyte group-5a antigen and acute lymphoblastic leukaemia.
Leucocyte group 5 has two dominant alleles (5a and 5b) which segregate independently of the major histocompatibility complex. The group-5 system was studied in a Caucasian population of controls and patients with acute lymphoblastic leukaemia. The 5a gene frequency was 0-09 in 72 controls and 0-38 in 39 patients with acute lymphoblastic leukaemia (p less than 0-001). 15 patients with acute myelogenous leukaemia and 12 patients with aplastic anaemia had 5a and 5b frequencies similar to those seen in the control population. It is concluded that 5a or a closely linked gene is involved in susceptibility to acute lymphoblastic leukaemia.
D000483:Alleles; D000741:Anemia, Aplastic / Q000235:genetics / Q000276:immunology; D000939:Epitopes; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D006680:HLA Antigens / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens