Histamine-releasing effect of a corticotrophin derivative. II. Mechanism of action of histamine release by C 44 680-Ba, compared with that of Cpd. 48/80, dextran and triton.
The mechanism of the histamine-liberating action of the synthetic polypeptide C 44 680-Ba, an alkyl-prolyl derivative of beta 1-19 corticotrophin, was investigated and compared with those of Compound 48/80, dextran, Melittin and Triton X-100. It was found that the release of histamine from rat peritoneal cells induced by the polypeptide is dependent on temperature, pH, calcium ions and energy-providing processes. In regard to these criteria, the mode of action of this histamine liberator resembles that of Compound 48/80 but is quite distinct from that of the unspecific substance Triton X-100.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology*; D004347:Drug Interactions; D005947:Glucose / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D010718:Phosphatidylserines / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D012966:Sodium Cyanide / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D003911:Dextrans; D010718:Phosphatidylserines; D011092:Polyethylene Glycols; D003189:p-Methoxy-N-methylphenethylamine; D000324:Adrenocorticotropic Hormone; D005947:Glucose; D012966:Sodium Cyanide; D002118:Calcium