title: Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial.
abstract: 40 adult outpatients with active endoscopically proven duodenal ulceration, who would otherwise have merited elective ulcer surgery, entered a double-blind trial of either cimetidine (1g/day) or placebo. After twenty-eight days, 17 of 20 (85%) patients receiving cimetidine showed ulcer healing, compared with 5 of 20 patients receiving placebo (p less than 0.0005). Patients receiving cimetidine had significantly more pain-free days and pain-free nights than those receiving placebo. There was good correlation between ulcer healing and symptomatic relief (p less than 0.0005).
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000863:Antacids / Q000008:administration & dosage / Q000627:therapeutic use; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology / Q000534:rehabilitation; D005260:Female; D005500:Follow-Up Studies; D005750:Gastric Juice / Q000378:metabolism; D006146:Guanidines / Q000008:administration & dosage* / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000453:epidemiology; D010434:Pepsin A / Q000378:metabolism; D010919:Placebos
chemical_list: D000863:Antacids; D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D010919:Placebos; D010434:Pepsin A