title: Cockroach cause of allergic asthma. Its specificity and immunologic profile.
abstract: To assess the etiologic role of cockroach antigen in bronchial asthma, 46 asthmatic subjects were studied using in vitro assays for total and cockroach-specific IgE antibodies (IgEcr) and the responsiveness of the skin and bronchial tree to the antigen challenge in vivo. Asthmatic subjects were divided into skin test-positive (PCR) and skin test-negative (NCR) groups according to immediate skin response to cockroach antigen. The 28 in the PCR group showed high total IgE (1,901 ng/ml) and a high cockroach-specific IgE antibody level (329%) in the serum compared to the 10 in the NCR group (IgE: 915 ng/ml, IgEcr:84%) (p less than 0.001). Bronchial challenge with the antigen revealed immediate asthmatic reaction (30/33) and late asthmatic reaction (16/33) in the PCR asthmatics, whereas the NCR asthmatics showed neither immediate asthmatic reaction (2/13 showed questionable decrease in FEV1) nor late asthmatic reaction (p less than 0.001). A marked increase in peripheral eosinophils (758% vs 121%) was noted following antigen inhalation in the skin test-positive asthmatics (p less than 0.025). The results indicate that cockroach antigen causes antigen-specific IgE-mediated bronchial asthma and peripheral eosinophilia in specifically sensitized asthmatic subjects.
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis; D000941:Antigens; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D001772:Blood Cell Count; D003058:Cockroaches / Q000276:immunology*; D004804:Eosinophils; D000939:Epitopes; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D008297:Male; D012129:Respiratory Function Tests
chemical_list: D000906:Antibodies; D000941:Antigens; D000939:Epitopes; D007073:Immunoglobulin E