Gut endocrinology: correlation of physiology and morphology.
The gastrointestinal tract is a large and complex endocrine organ. Elucidation of its nature, and the actions of its individual hormonal components, has advanced in recent years following the purification and sequencing of six probable hormones and the subsequent development of radioimmunoassay techniques for their measurement and immunocytochemistry for the determination of their cellular origin. Immunoassay and immunocytochemistry are clearly complimentary to each other in providing a fuller understanding of the dynamics of endocrine function at the cellular level. This is illustrated in the examples described in this paper.
D000818:Animals; D004064:Digestive System / Q000166:cytology / Q000378:metabolism; D004068:Digestive System Physiological Phenomena; D004285:Dogs; D005753:Gastric Mucosa / Q000032:analysis / Q000166:cytology / Q000378:metabolism; D005755:Gastrins / Q000032:analysis / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D004763:Glucagon-Like Peptides / Q000032:analysis / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007082:Ileum / Q000032:analysis / Q000166:cytology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000032:analysis / Q000166:cytology / Q000378:metabolism; D010179:Pancreas / Q000032:analysis / Q000166:cytology / Q000378:metabolism; D011863:Radioimmunoassay; D012633:Secretin / Q000032:analysis / Q000378:metabolism; D013004:Somatostatin / Q000032:analysis / Q000378:metabolism; D013194:Staining and Labeling; D013552:Swine; D014660:Vasoactive Intestinal Peptide / Q000032:analysis / Q000378:metabolism
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D004763:Glucagon-Like Peptides