Systemic lupus erythematosus with negative LE cells and antinuclear factor.
In the course of a prospective study of 165 patients with SLE a subgroup of eight patients with active SLE yet with persistently negative tests for ANF and LE cells was identified. These patients were characterized by a photosensitive skin rash with a negative lupus band test, a high incidence of arthritis, mild form of renal disease, and a positive family history for connective tissue disease. Antibodies to DNA and cytoplasmic antigens were detected in a few.
D000328:Adult; D000974:Antibodies, Antinuclear; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008875:Middle Aged; D009504:Neutrophils
D000974:Antibodies, Antinuclear; D004247:DNA