Ionic composition and cardiotoxicity of dimeric contrast media at injection into the coronary arteries of rabbits.
The relation between ionic composition and cardiotoxicity of two dimers, iocarmate and iozomate, was investigated by selective injection into the left and right coronary arteries, Least toxic reactions developed at a sodium concentration of 263 to 315 mmol/l for sodium-meglumine iocarmate and 271 to 379 mmol/l for sodium-meglumine iozomate.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D005117:Cardiac Complexes, Premature / Q000139:chemically induced; D017023:Coronary Angiography; D003973:Diatrizoate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006327:Heart Block / Q000139:chemically induced; D006329:Heart Conduction System / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000633:toxicity*; D007483:Iothalamic Acid / Q000031:analogs & derivatives*; D009994:Osmolar Concentration; D011817:Rabbits; D014693:Ventricular Fibrillation / Q000139:chemically induced
D003973:Diatrizoate; D007483:Iothalamic Acid; D007482:Iothalamate Meglumine