Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells.
Transformation of cultured fibroblasts usually results in a decrease in a high molecular weight cell surface glycoprotein (LETS protein) and often in increased numbers of surface microvilli and ruffles. We have isolated such a major cell surface glycoprotein from chick embryo fibroblasts; this protein, CSP, is decreased after transformation. Treatment of a mouse tumor cell line (SV1), L929 cells, and transformed chick fibroblasts with CSP results in a decrease in the number of microvilli and marginal ruffles, accompanied by restoration of a more normal morphology.
D000199:Actins / Q000494:pharmacology; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic; D003094:Collagen / Q000494:pharmacology; D005340:Fibrinogen / Q000494:pharmacology; D006023:Glycoproteins / Q000494:pharmacology*; D006657:Histones / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000494:pharmacology; D008565:Membrane Proteins / Q000494:pharmacology*; D009218:Myosins / Q000494:pharmacology; D011107:Polylysine / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D000509:alpha-Fetoproteins / Q000494:pharmacology
D000199:Actins; D006023:Glycoproteins; D006657:Histones; D008565:Membrane Proteins; D000509:alpha-Fetoproteins; D011107:Polylysine; D012710:Serum Albumin, Bovine; D005340:Fibrinogen; D006820:Hyaluronic Acid; D003094:Collagen; D009218:Myosins