The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells.
Murine neoplastic mast cells which have been loaded with exogenous labelled histamine, released 14C-histamine when exposed to increasing concentrations of phenylephrine and noradrenaline. Adrenaline was only slightly effective, while isoprenaline and dibutyryl-cyclic-AMP were fully inactive. The release of histamine evoked by alpha-adrenergic agonists was antagonized by phentolamine, and left unchanged by practolol and cocaine. It is concluded that alpha-adrenoceptors may be valuable in evoking histamine release by murine neoplastic mast cells.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002460:Cell Line; D003042:Cocaine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D012515:Mast-Cell Sarcoma / Q000503:physiopathology*; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D003994:Bucladesine; D003042:Cocaine; D007545:Isoproterenol; D011217:Practolol; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine