title: [Humoral immunity and blastic transformation of lymphocytes in trisomy 21].
abstract: Studies of immunologic parameters in 52 children with trisomy 21 revealed that -the changes in serum immunoglobulin patterns were minimal, although some delay in the age-dependent rise of IgG concentration was observed; -lymphocyte reactivity to phytohemagglutinin showed a shift with maximal 3H-thymidine incorporation at low PHA concentration; -presence of HBs antigen at an increased incidence, possible existence of anti-thyroid antibodies in serum of trisomy patients and also in that of their parents, abnormalities in phagocytosis, illustrate that trisomy 21 can be associated with multiple immunologic dysfunctions.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007223:Infant; D008213:Lymphocyte Activation; D008297:Male; D012463:Saliva / Q000276:immunology; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006511:Hepatitis B Antigens; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D000509:alpha-Fetoproteins
vernacular_title: Etude de l'immunité humorale et de la transformation blastique des lymphocytes chez le trisomique 21