Neurophysin biosynthesis: conversion of a putative precursor during axonal transport.
[35S]Cysteine injected adjacent to the supraoptic nucleus of the rat is rapidly incorporated into a 20,000-dalton protein that, in time, is converted to a 12,000-dalton labeled protein, neurophysin. This putative precursor of neurophysin appears to be synthesized in the supraoptic nucleus and transformed to neurophysin and related peptides during axonal transport to the neurohypophysis.
D000818:Animals; D001370:Axonal Transport; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008473:Median Eminence / Q000378:metabolism; D008970:Molecular Weight; D009481:Neurophysins / Q000096:biosynthesis*; D010904:Pituitary Gland, Posterior / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats; D013495:Supraoptic Nucleus / Q000378:metabolism; D013997:Time Factors; D014667:Vasopressins / Q000096:biosynthesis
D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins