title: [Primary liver cell carcinoma, aetiology and clinical picture (author's transl)].
abstract: Geographic area, age and sex influence the epidemiology of hepatoma. Aetiological factors are aflatoxins, sex hormones, thorotrast, alpha 1-antitrypsin deficiency, immunosuppression, vinylchloride, parasites, cirrhosis of the liver, and the hepatitis-B virus. Early diagnosis of the tumour is possible using alpha 1-fetoprotein estimations and modern morphological methods, particularly scintiscanning. Tumour resection is therapeutically desirable, while selective chemotherapy remains palliative and liver transplantation failed to prolong survival.
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary; D000348:Aflatoxins / Q000633:toxicity; D000728:Androgens / Q000009:adverse effects; D001859:Bone Neoplasms / Q000556:secondary; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D005260:Female; D006511:Hepatitis B Antigens / Q000009:adverse effects; D006801:Humans; D007165:Immunosuppression Therapy; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000209:etiology*; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009381:Neoplasms, Radiation-Induced; D009787:Occupational Medicine; D010272:Parasitic Diseases / Q000150:complications; D011169:Portal Vein; D013927:Thrombosis / Q000209:etiology; D014752:Vinyl Chloride / Q000009:adverse effects; D019896:alpha 1-Antitrypsin Deficiency; D000509:alpha-Fetoproteins / Q000097:blood
chemical_list: D000348:Aflatoxins; D000728:Androgens; D002273:Carcinogens; D003278:Contraceptives, Oral, Hormonal; D006511:Hepatitis B Antigens; D000509:alpha-Fetoproteins; D014752:Vinyl Chloride
vernacular_title: Das primäre Leberzellkarzinom, Atiologie und Klinik.