Dietary cholesterol is co-carcinogenic for human colon cancer.
Colorectal carcinoma is becoming the most common form of visceral cancer in Western populations. A fat-related dietary factor is implicated in its pathogenesis, and evidence in man suggests that this factor may be cholesterol. Dietary cholesterol is co-carcinogenic in animals with colon cancer, and there is indirect evidence for a similar role in man. It is proposed that prolonged exposure to dietary cholesterol is co-carcinogenic for human colon cancer in that it facilitates the development, growth, and spread of this disease.
D000818:Animals; D001647:Bile Acids and Salts / Q000009:adverse effects / Q000378:metabolism; D002273:Carcinogens; D002791:Cholesterol, Dietary / Q000009:adverse effects* / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D003110:Colonic Neoplasms / Q000209:etiology*; D006801:Humans
D001647:Bile Acids and Salts; D002273:Carcinogens; D002791:Cholesterol, Dietary