Inhibition of prostaglandin synthesis as a treatment for biliary pain.
Twenty patients with confirmed gallbladder disease were treated with intravenous indomethacin during 24 separate attacks of biliary pain. In all cases the pain was promptly relieved and there were no important side-effects. Indomethacin, and inhibitor of prostaglandin synthesis, may reduce intraluminal pressure in the gallbladder, and relieve pain.
D002769:Cholelithiasis / Q000188:drug therapy*; D003085:Colic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*; D011453:Prostaglandins / Q000096:biosynthesis
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D007213:Indomethacin