Uptake of taurine by platelets in retinitis pigmentosa.
Uptake of 3H-taurine by platelets from twelve patients with retinitis pigmentosa (R.P.) and from healthy controls was measured. Platelets were incubated in autologous plasma with 3H-taurine for different times and at different substrate concentrations. The uptake of taurine by R.P. platelets at each incubation time was about two-thirds of the control value, the difference being statistically significant. Km was about the same, but Vmax was lower in R.P. platelets. The results suggest that R.P. is a disease affecting not only the eye but also taurine transport and/or storage in general.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D007553:Isotope Labeling; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000097:blood*; D013654:Taurine / Q000097:blood* / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D013654:Taurine