Encephalitogenic activity of the N-terminal part of bovine myelin basic protein in rabbits.
The disease-inducing activity of the N-terminal part (residues 1-42) of bovine myelin basic protein in rabbits is localized to two regions. One encephalitogenic determined probably incorporates at least one of the lysine residues (Nos. 4 and 11); the other is within residues 20-36. It is concluded that region 1-42 shows a comparably strong degree of encephalitogenicity for rabbits.
D000818:Animals; D000941:Antigens; D001933:Brain Stem / Q000276:immunology / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D000939:Epitopes; D007114:Immunization; D004676:Myelin Basic Protein / Q000276:immunology*; D009185:Myelin Proteins / Q000276:immunology*; D010443:Peptide Chain Termination, Translational; D010446:Peptide Fragments / Q000032:analysis / Q000276:immunology; D011817:Rabbits
D000941:Antigens; D000939:Epitopes; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D010446:Peptide Fragments