[Results of polychemotherapy and immunotherapy in acute leukemias].
For the purpose of evaluating the efficiency of an unspecific immunostimulation in acute leukaemias the results of treatment obtained from two groups of patients (a total of 55 children) were compiled. In the first group an unspecific immunostimulation with vaccination (BCG, diphtheria-tetanus-pertussis, measles) could be observed after the induction of remission during a cytostatic maintenance therapy. In the second group a polychemical therapy and the CNS-irradiation was applied according to the treatment scheme developed by the working team of Donald Pinkel. The group of patients treated with unspecific immunostimulation involved a high percentage of surviving children. In total there was no essential difference between the treatment results of both schemes of therapy during our period of observation. As before, the treatment of hyperleukocytic forms of leukaemias will cause particular difficulties.
D000208:Acute Disease; D001500:BCG Vaccine; D001932:Brain Neoplasms / Q000532:radiotherapy; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D004168:Diphtheria Toxoid / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006050:Gold Radioisotopes / Q000627:therapeutic use; D006801:Humans; D007278:Injections, Spinal; D007938:Leukemia / Q000628:therapy*; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D010567:Pertussis Vaccine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013745:Tetanus Toxoid / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D001500:BCG Vaccine; D004168:Diphtheria Toxoid; D006050:Gold Radioisotopes; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid; D014750:Vincristine; D003520:Cyclophosphamide; D015122:Mercaptopurine; D011241:Prednisone; D008727:Methotrexate
Ergebnisse der Polychemotherapie und Immuntherapieversuche bei akuten Leukosen