title: Antithyroid-antibody activity in the snyovial fluid of patients with various arthritides.
abstract: Microsomal and thyroglobulin autoantibody activity has been detected in synovial fluid from 34 of 50 patients with various arthritides (rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis, and gout). Serum from only 4 of these patients showed thyroid-autoantibody activity, and the serum titres were considerably lower than the synovial-fluid titres. This suggests that thyroid autoantibody is produced locally in the joints of these patients.
mesh_terms: D000974:Antibodies, Antinuclear / Q000302:isolation & purification*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D006073:Gout / Q000276:immunology; D006801:Humans; D008861:Microsomes / Q000276:immunology; D010003:Osteoarthritis / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology* / Q000473:pathology; D012217:Rheumatoid Factor / Q000302:isolation & purification*; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013582:Synovial Fluid / Q000166:cytology / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology*; D013961:Thyroid Gland / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D012217:Rheumatoid Factor; D013954:Thyroglobulin