Studies on the sterilization of pharmaceutical base materials with ionizing radiation and ethylene oxide.
The use of ionizing radiation and ethylene oxide for the sterilization of pharmaceutical base materials of animal origin, used to produce organopreparations, was studied. The materials included liver extract, pancreas extract, dried thyroid and intrinsic factor. The effective sterilizing doses for the examined materials and dependence between effective ionizing radiation dose and primary contamination were determined.
D000818:Animals; D001688:Biological Products; D004340:Drug Contamination / Q000517:prevention & control*; D005027:Ethylene Oxide / Q000008:administration & dosage / Q000494:pharmacology*; D007437:Intrinsic Factor / Q000528:radiation effects; D008110:Liver Extracts / Q000528:radiation effects; D010184:Pancreatic Extracts / Q000528:radiation effects; D010592:Pharmaceutic Aids; D011829:Radiation Dosage; D011830:Radiation Effects; D011839:Radiation, Ionizing; D013242:Sterilization / Q000379:methods*; D013962:Thyroid (USP) / Q000528:radiation effects; D014020:Tissue Extracts
D001688:Biological Products; D008110:Liver Extracts; D010184:Pancreatic Extracts; D010592:Pharmaceutic Aids; D013962:Thyroid (USP); D014020:Tissue Extracts; D007437:Intrinsic Factor; D005027:Ethylene Oxide