Immunological abnormalities in patients who had the oculomucocutaneous syndrome associated with practolol therapy.
Patients with and without adverse reactions on practolol therapy showed altered immune responses. There was cutaneous anergy to Candida albicans and streptokinase/streptodornase antigens and depression of lymphocyte function in vitro. Anticomplementary activity and a wide range of autoantibodies were found in patients who had received practolol.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000302:isolation & purification*; D001327:Autoimmune Diseases / Q000175:diagnosis; D003327:Coronary Disease / Q000188:drug therapy; D003875:Drug Eruptions / Q000150:complications / Q000276:immunology*; D005128:Eye Diseases / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011217:Practolol / Q000009:adverse effects* / Q000627:therapeutic use; D013577:Syndrome
D001323:Autoantibodies; D011217:Practolol