Three cases of hemoglobin O Arab.
Three new cases of Hb 0 Arab in two families are reported from districts of Bulgaria, where a carrier state  of this abnormal hemoglobin has not been established so far. One of the propositi is a double heterozygote for Hb 0 Ar/beta(0)-thalassemia. His father is a simple heterozygote for Hb 0 Ar with clear-cut cytomorphological stigmata, indicating hemoglobinosis. The second propositus, according to clinical and laboratory data is also a double heterozygote for Hb 0 Ar and beta(0)-thalassemia. The carriers investigated are of Bulgarian nationality. Their territorial origin supportsthe thesis that the gene mutation for Hb 0 Arab most probably has taken place out of the present boundaries of Bulgaria.
D000328:Adult; D002031:Bulgaria; D005260:Female; D005319:Fetal Hemoglobin; D006453:Hemoglobinopathies / Q000150:complications / Q000235:genetics*; D006455:Hemoglobins, Abnormal; D006529:Hepatomegaly / Q000209:etiology; D006579:Heterozygote; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000209:etiology
D006455:Hemoglobins, Abnormal; D005319:Fetal Hemoglobin