[Cerebrospinal fluid gamma globulins in neurological disorders affecting black Africans (author's transl)].
Four hundred C.S.F. electrophoreses were carried out in black West Africans (Ivory Coast) suffering from inflammatory disorders of the nervous system. In the normal state, the C.S.F. of the black African contains more gamma globulins than that of the white (15.8% as opposed to 10%). The study provides indirect evidence of the classical notion of the extreme rarity of DS (Disseminated sclerosis) in the tropics. Hypergammaglobulinorachia was demonstrated in 22% of cases, the two principal disorders responsible being trypanosomiasis (57.3%) and sub-acute sclerosing panencephalitis (16.8%). The oligoclonal distribution described in trypanosomiasis was not found. On the contrary, a homogeneous appearance of the gamma zone was constantly demonstrated (49/50). It is possible that these differences are related to the various phases in the course of the disease, and that oligoclonal disturbation is a marker of the auto-immune phase.
D000354:Africa, Western; D044383:Black People; D004586:Electrophoresis; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D009422:Nervous System Diseases / Q000276:immunology*; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology; D005719:gamma-Globulins / Q000134:cerebrospinal fluid*
D005719:gamma-Globulins
Les gamma-globulines du liquide céphalo-rachidien dans les affections neurologiques du Noir African.