title: Department of medicine - rheumatology service rheumatic diseases study group.
abstract: Human heavy chain diseases offer an opportunity to examine the molecular events taking place in cells which produce naturally occurring structural variants of a well-studied complex protein. Extensive structural analyses have been carried out on many of these proteins and have revealed the existence of certain characteristic features. Current studies are beginning to elucidate the molecular biology underlying these structural features.
mesh_terms: D000939:Epitopes; D006362:Heavy Chain Disease / Q000235:genetics / Q000276:immunology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis; D007136:Immunoglobulins / Q000378:metabolism; D009101:Multiple Myeloma; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000302:isolation & purification
chemical_list: D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007136:Immunoglobulins; D012333:RNA, Messenger