Induction of antibody to the "y" determinant of HBsAg in a chimpanzee carrier of HBsAg subtype "adw".
Antibody to the y determinant of hepatitis B surface antigen (HBsAg) was induced in a chimpanzee chronically infected with hepatitis B virus and circulating HBsAg subtype adw. The chimpanzee was immunized with purified preparations of HBsAg subtypes adw and ayw. Six weeks after immunization, antibody to HBsAg (anti-HBs) specific for the y determinant, appeared. No change occurred in titers of HBsAg or antibody to hepatitis B core antigen (anti-HBc) and "e" antigen remained detectable. The circulating HBsAg subtype adw remained present despite the persistence of anti-y for greater than 8 months.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002353:Carrier State / Q000276:immunology*; D002908:Chronic Disease; D000939:Epitopes; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D002679:Pan troglodytes
D000914:Antibodies, Viral; D000939:Epitopes; D006514:Hepatitis B Surface Antigens