Axoplasmic and nonaxoplasmic transport along the optic pathway of albino rabbits; a theoretical pattern of distribution.
Distribution of nonaxoplasmically transported material along the optic pathway of the rabbit was studied after blockage of the axonal flow by vinblastine, and a clear pattern of distribution of the axoplasmic transport was deduced by subtraction from the pattern seen in nontreated animals. Vascular participation in the nonaxoplasmic transport was certified by autoradiographic studies. The theoretical pattern of distribution of axoplasmic transport in the optic system under ideal conditions was calculated from an idealized model system. From the comparison of theoretical and experimental patterns, partial obstruction of the axonal flow likely occurs at the optic foramen and chiasma.
D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport / Q000187:drug effects*; D008433:Mathematics; D008954:Models, Biological; D009897:Optic Chiasm / Q000502:physiology; D009900:Optic Nerve / Q000502:physiology; D011817:Rabbits; D014747:Vinblastine / Q000494:pharmacology*; D014795:Visual Pathways / Q000502:physiology*
D014747:Vinblastine