title: The binding of phenobarbitone and phenytoin to kwashiorkor serum.
abstract: The binding of phenytoin and phenobarbitone to the serum of kwashiorkor patients and normal serum has been investigated. There was no alteration in the binding of phenytoin. However, there was a decrease in the binding of phenobarbitone to kwashiorkor serum, and this was particularly striking in the presence of added phenytoin. It was confirmed that phenytoin was almost exclusively albumin-bound, while phenobarbitone was bound to albumin, alpha 1-and alpha 2-globulin in almost equal proportions.
mesh_terms: D000510:Alpha-Globulins; D001798:Blood Proteins; D002648:Child; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D007732:Kwashiorkor / Q000097:blood*; D010634:Phenobarbital / Q000097:blood* / Q000494:pharmacology; D010672:Phenytoin / Q000097:blood* / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin
chemical_list: D000510:Alpha-Globulins; D001798:Blood Proteins; D012709:Serum Albumin; D010672:Phenytoin; D010634:Phenobarbital