Effect of histamine H2-receptor antagonists on delayed hypersensitivity.
The delayed skin-test response to four antigens was assessed before and after 6 weeks' cimetidine therapy in patients with duodenal-ulcer disease. In the eight patients who received cimetidine there was a significant increase in both erythema and induration after six weeks' cimetidine therapy. In contrast, the intensity of delayed-hypersensitivity reactions at 6 weeks was not increased in eight control patients who did not receive cimetidine. These studies indicate that therapy with an H2-receptor antagonist may be associated with an augmentation of delayed hypersensitivity responses.
D002927:Cimetidine / Q000276:immunology* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D004381:Duodenal Ulcer / Q000188:drug therapy; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D006146:Guanidines / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D012867:Skin / Q000276:immunology; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine