An experimental kidney disease in dogs produced by injection of heterologous antisera to dog tubular fraction 3 antigen.
Glomerular disease characterised by morphological alterations of the glomerular basement membrane and the mesangium was produced in dogs by injections of heterologous anti-dog renal tubular fraction 3 antibody. The renal lesion was characterised by irregular thickening of the glomerular basement membrane, with electron-dense deposits and loose granular material within it.
D000818:Animals; D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001485:Basement Membrane / Q000648:ultrastructure; D004285:Dogs; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D007105:Immune Complex Diseases; D007678:Kidney Glomerulus / Q000648:ultrastructure; D007684:Kidney Tubules / Q000276:immunology*; D011817:Rabbits; D005719:gamma-Globulins
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D005719:gamma-Globulins