Rubella infection and diabetes mellitus.
The incidence of diabetes mellitus was increased in patients with congenital rubella. Experimental congenital rubella infection in rabbits caused histological changes in the beta-cells of the pancreatic islets similar to those found in mice made diabetic by the M variant of the encephalomyocarditis virus. It is concluded that the diabetes seen in congenital rubella is due to viral infection of the pancreatic islet cells.
D000328:Adult; D000818:Animals; D002648:Child; D003593:Cytoplasm / Q000648:ultrastructure; D003920:Diabetes Mellitus / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology; D005260:Female; D005333:Fetus / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D011247:Pregnancy; D011817:Rabbits; D012409:Rubella / Q000150:complications* / Q000151:congenital / Q000196:embryology