HLA antigens in severe pre-eclampsia.
When the HLA types of 80 pre-eclamptic women and their husbands and 83 control couples were compared significantly more pre-eclamptic women had only one identifiable HLA B antigen, and were presumed to be homozygous at this locus. Those who were homozygous for HLA B were more likely to be homozygous for HLA A as well, and more likely to be homozygous for HLA A as well, and to have more severe pre-eclampsia. There was neither increased HLA incompatibility nor greater antigen-sharing between pre-eclamptic women and their husbands, but maternal HLA A and B homozygosity reduced the number of antigenic disparities between pre-eclamptic women and their husbands. The data are consistent with the hypothesis that maternal recessive immune-response genes may contribute to the development of pre-eclampsia. Alternatively maternal HLA homozygosity may predispose to fetal changes comparable to runting.
D000939:Epitopes; D005260:Female; D005802:Genes, MHC Class II; D005808:Genes, Recessive; D006086:Graft vs Host Disease / Q000235:genetics*; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D008297:Male; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies
D000939:Epitopes; D006680:HLA Antigens