[Immunoglobulin FAB-fragments: specific activity and reactogenicity. III. Comparative study of the antigenic properties of anti-encephalitic gamma-globulin and FAB-fragments isolated from it].
Parenteral administration of antiencephalytic gamma-globulin and of the Fab-fragments, extracted from it, to rabbits stimulated the formation of specific antibodies. The maximal blood serum specific antibody level in rabbits reimmunized with Fab-fragments was much lower than that following the reimmunization of rabbits with gamma-globulin. Antibodies specific to gamma-globulin and Fab-fragments were concentrated in the gamma-globulin fraction of the immune sera and could be referred to the immunoglobulins of G class.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000917:Antibody Formation; D000918:Antibody Specificity; D000941:Antigens; D002850:Chromatography, Gel; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D011817:Rabbits / Q000276:immunology; D005719:gamma-Globulins
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D005719:gamma-Globulins
FAB-fragmenty immunoglobulinov: izuchenie spetsificheskoĭ aktivnosti i reaktogennosti. Soobshchenie III. Sravnitel'noe izuchenie antigennykh svoĭstv protivońtsefalitnogo gamma-globulina i vydelennykh iz nego FAB-fragmentov.