Sexual precocity in a male due to thoracic polyembryoma.
A 7-year-old boy with sexual precocity of recent onset was found to have elevated levels of chorionic gonadotropin, alpha fetoprotein, and testosterone. Removal of a retropleural, posterior mediastinal mass with an intraspinous epidural extension was followed by prompt declines in the plasma concentrations of the tumor markers and cessation  of adolescent development. The neoplasm proved to be a polyembryoma, unusual in the multiplicity of its embryoid bodies and extra gonadal location. Following local irradiation and two years of systemic chemotherapy, the patient, now 13 years of age, has done well except for evidence of testicular tubular insufficiency.
D002648:Child; D006063:Chorionic Gonadotropin / Q000378:metabolism; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology* / Q000378:metabolism; D013724:Teratoma / Q000150:complications* / Q000473:pathology; D013739:Testosterone / Q000378:metabolism; D013899:Thoracic Neoplasms / Q000150:complications* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000378:metabolism
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D013739:Testosterone