title: [Studies on the diffusion of cephapirin into prostatic tissue].
abstract: After i.v.-application of 2 grams of Cephaprin (= Bristocef) to 13 patients with prostatic adenoma the mean serum concentrations after 30 minutes were 50 microgram/ml and 21.5 microngram/ml after 60 minutes. The corresponding tissue values were 20.8 and microgram/g respectively in prostatic tissue. The evaluated serumand tissue cncentrations are suited to the therapy of infections with cephapirin sensitive rods.
mesh_terms: D000368:Aged; D002511:Cephalosporins / Q000378:metabolism*; D002514:Cephapirin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002514:Cephapirin
vernacular_title: Untersuchungen zur Diffusion von Cephapirin in das Prostata-Gewebe.