title: Ionic composition and cardiotoxicity of dimeric contrast media at injection into the coronary arteries of rabbits.
abstract: The relation between ionic composition and cardiotoxicity of two dimers, iocarmate and iozomate, was investigated by selective injection into the left and right coronary arteries, Least toxic reactions developed at a sodium concentration of 263 to 315 mmol/l for sodium-meglumine iocarmate and 271 to 379 mmol/l for sodium-meglumine iozomate.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D005117:Cardiac Complexes, Premature / Q000139:chemically induced; D017023:Coronary Angiography; D003973:Diatrizoate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006327:Heart Block / Q000139:chemically induced; D006329:Heart Conduction System / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000633:toxicity*; D007483:Iothalamic Acid / Q000031:analogs & derivatives*; D009994:Osmolar Concentration; D011817:Rabbits; D014693:Ventricular Fibrillation / Q000139:chemically induced
chemical_list: D003973:Diatrizoate; D007483:Iothalamic Acid; D007482:Iothalamate Meglumine