Polyamine interaction with pregnancy serum in suppression of lymphocyte transformation.
Biogenic polyamines interacting with pregnancy serum elicit potent suppression of lymphocyte transformation in vitro. Within the assay limits, activity was first shown after about 15 weeks' gestation and reached its highest level at about 28 weeks. This level was maintained until term. It is thought that specific humoral amine oxidases were the cause. Fetal-cord serum and non-pregnancy serum were inactive. This system may have an immunoregulatory function in pregnancy.
D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011700:Putrescine / Q000097:blood / Q000276:immunology; D051381:Rats; D013096:Spermine / Q000097:blood / Q000276:immunology
D007106:Immune Sera; D007166:Immunosuppressive Agents; D013096:Spermine; D008995:Monoamine Oxidase; D011700:Putrescine