Binding of fatty acids and tryptophan to alpha-fetoprotein from fetal pigs.
Using gel electrophoresis and autoradiography, we have shown that plamitic, stearic, oleic and arachidonic acids as well as tryptophan bind to alpha-fetoprotein derived from fetal swine serum. It is also shown that these ligands bind to albumin from both fetal and adult swine serum. The results suggest that alpha-fetoprotein in the fetus has transport functions similar to albumin in the adult.
D000818:Animals; D001095:Arachidonic Acids; D005230:Fatty Acids, Nonesterified; D005333:Fetus; D009829:Oleic Acids; D010169:Palmitic Acids; D011485:Protein Binding; D013229:Stearic Acids; D013552:Swine; D014364:Tryptophan; D000509:alpha-Fetoproteins
D001095:Arachidonic Acids; D005230:Fatty Acids, Nonesterified; D009829:Oleic Acids; D010169:Palmitic Acids; D013229:Stearic Acids; D000509:alpha-Fetoproteins; D014364:Tryptophan