Acquired resistance to parathyroid hormone.
Studies are presented in a patient with pseudohypoparathyroidism who showed a partial response to parathyroid extract. Resistance to the extract was observed after its short-term administration for the gourth time. Serum from the patient contained antibodies of the gamma G globulin class which bound 125I-labelled bovine parathyroid hormone. Prior incubation of parathyroid hormone with the serum prevented the activation in vitro of adenylate cyclase from pork renal cortex. The antibodies were directed primarily toward the C-terminal portion of the molecule. Thus, clinical resistance to parathyroid hormone is attributed to specific antibodies.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000293:Adolescent; D000917:Antibody Formation; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000652:urine; D004351:Drug Resistance; D006801:Humans; D008297:Male; D010280:Parathyroid Glands; D010281:Parathyroid Hormone / Q000276:immunology*; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011547:Pseudohypoparathyroidism / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D013960:Thyroid Function Tests; D014020:Tissue Extracts / Q000276:immunology / Q000627:therapeutic use*
D010281:Parathyroid Hormone; D010710:Phosphates; D014020:Tissue Extracts; D010758:Phosphorus; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium