[The acid-base equilibrium during mouse lymphoblastic leukemia].
In transplantable and in spontaneous lymphoblastic mouse leukemia blood pH, PCO2, TCO2 and BB were examined. Spontaneous Gross-leukemia in AKR mice was found to develop in its final phase respiratory acidosis. Transplantable (TAL) leukemia of AKR mice presents from the onset a tendency toward respiratory acidosis. "L-1210"-leukemia, on the contrary, was shown to alcalise the recipients during the first 8 days after inoculation, later on it can bring about an acidosis. The pH-deviations in "L-1210"-leukemia display a respiratory character in syngeneic DBA/2J recipients, whereas in semiallogeneic recipients the observed changes are metabolic or mixt in nature. This finding strongly argues for the importance of histocompatibility. Intranodally inoculated animals distinctly differ in their parameters in comparison to intravenously and intraperitoneally recipients, hence, an important role of the tissular-milieu which is put first in contact with the leukemic factor must be concluded.
D000406:AKR murine leukemia virus; D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000209:etiology; D000471:Alkalosis / Q000209:etiology; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D007939:Leukemia L1210 / Q000378:metabolism; D007942:Leukemia, Experimental / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D051379:Mice; D008806:Mice, Inbred AKR; D009368:Neoplasm Transplantation
D002245:Carbon Dioxide
Das Säure-Basen-Gleichgewicht im Verlauf lymphoblastischer Leukämien der Maus