Immune mechanisms in leukemia role of the Ia antigens.
We have shown that the selective removal of cells possessing Ia determinants coded by the I-A, I-B, and I-J regions of the H-2 gene complex completely abrogates the protective capacity of nylon-wool-purified T lymphocytes against leukemic challenge. This suggests that the Ia antigen bearing T cells play an important role in tumor immunity.
D000818:Animals; D003165:Complement System Proteins; D000939:Epitopes; D007165:Immunosuppression Therapy; D007518:Isoantibodies; D007519:Isoantigens; D007938:Leukemia / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D007518:Isoantibodies; D007519:Isoantigens; D003165:Complement System Proteins