Serum protein changes associated with alpha1-antitrypsin deficiency.
Using a radial immunodiffusion technique, the concentrations of eight serum proteins have been measured in sera from 60 chest clinic patients previously shown to have abnormally low alpha1-antitrypsin levels, and in 60 age and sex matched control sera. Of the proteins, only alpha2-macroglobulin showed a highly significant increase in the alpha1-antitrypsin deficient group. The findings confirm a previously reported association between alpha1-antitrypsin deficiency and increased alpha2-macroglobulin, and lend support to the suggestion that the rise in alpha2-macroglobulin is a specific compensatory response.
D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D019896:alpha 1-Antitrypsin Deficiency; D000511:alpha-Macroglobulins / Q000378:metabolism*
D001798:Blood Proteins; D007075:Immunoglobulin M; D012709:Serum Albumin; D000511:alpha-Macroglobulins