Fulminant hepatic failure associated with methyldopa.
A patient with fatal submassive hepatic necrosis after methyldopa is described. Patient had positive L.E. cell preparation. The literature and the two previous cases of submassive hepatic necrosis were briefly reviewed. Methyldopa occasionally produces severe hepatitis, chronic active and rarely submassive necrosis.
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008750:Methyldopa / Q000009:adverse effects*; D009336:Necrosis / Q000139:chemically induced*; D009504:Neutrophils
D008750:Methyldopa