Studies on non-H-2 linked lymphocyte activating determinants. I. Description of the cell type bearing the Mls product.
The non-H-2 linked, lymphocyte activating determinants (LADs), which are coded by the minor (histocompatibility) lymphocyte stimulating locus (Mls), were detected on B lymphocytes, but not on immunoglobuin (Ig) negative or on theta positive T lymphocytes. These determinants, like the complement receptor and surface IgD, develop late in neonatal life. Thus, the Mls coded LADs mark a population of B lymphocytes which are not present in the spleens of newborn to 2-week-old mice. Studies of B lymphocytes derived from the spleens of adult mice indicated that the cells bear the Mls coded LADs have a high density of surface Ig and possess the complement receptor.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002469:Cell Separation; D000939:Epitopes; D005815:Genetic Code; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D007106:Immune Sera / Q000494:pharmacology; D007075:Immunoglobulin M; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D014176:Protein Biosynthesis; D011828:Radiation Chimera; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012995:Solubility; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell