Progesterone derivative binds to cardiac ouabain receptor and shows dissociation between sodium pump inhibition and increased contractile force.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002715:Chlormadinone Acetate / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010042:Ouabain / Q000378:metabolism* / Q000494:pharmacology; D045167:Progesterone Congeners / Q000378:metabolism* / Q000494:pharmacology; D011955:Receptors, Drug / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D045167:Progesterone Congeners; D011955:Receptors, Drug; D002715:Chlormadinone Acetate; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose