Relation between hypotensive effect in cats and reactions in children using normal human immunoglobulin.
The paper deals with the rare adverse reactions following administration of normal human immunoglobulins in Bulgaria. Experimental work has shown that such lots cause hypotensive effect in cats and lead to the release of pharmacologically active substances, measured biologically and spectrofluorometrically. The same immunoglobulins give two peaks of IgG aggregates by gel-chromatography and possess high anti-complementary activity. The possible relation between hypotensive effect in cats and reactions in children is discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002648:Child; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D006636:Histamine Release; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D007074:Immunoglobulin G / Q000009:adverse effects*; D007136:Immunoglobulins / Q000592:standards; D066298:In Vitro Techniques; D012119:Respiration / Q000187:drug effects
D007074:Immunoglobulin G; D007136:Immunoglobulins; D006632:Histamine