[Experimental studies into syncarcinogenesis. 7th communication: Syncarcinogenic effects of polycylic aromatic hydrocarbons (PAH) in epicutaneous tests in mice].
A mixture of 11 carcinogenic and noncarcinogenic hydrocarbons was applied to the shorn skin of the back of 3400 female NMRI-mice. The proportion of the hydrocarbons in the mixture corresponded to the analytical findings in condensates of cigarette smoke, automobil exhaust gas, and preservation curing smoke and tar. Antagonistic effects by the individual hydrocarbons in the mixture were not observed, on the contrary the substances in the mixture showed additive effects. There were no differences in the mode of action of the different mixtures.
D000818:Animals; D002273:Carcinogens; D004357:Drug Synergism; D005260:Female; D005519:Food Preservation; D051379:Mice; D009374:Neoplasms, Experimental; D011083:Polycyclic Compounds / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000139:chemically induced*; D012906:Smoke; D012907:Smoking / Q000150:complications; D001335:Vehicle Emissions
D002273:Carcinogens; D011083:Polycyclic Compounds; D012906:Smoke; D001335:Vehicle Emissions
Experimentelle Untersuchungen zur Syncarcinogenese. 7. Mitteilung: Syncarcinogene Wirkung von polycyclischen aromatischen Kohlenwasserstoffen (PAH) im Epicutantest an der Mäusehaut