[Distribution of gamma-hexachlorcyclohexane in subcellular fractions of the liver and brain].
The character of the gamma-HCCH distribution in the subcellular fractions of the liver and brain of albino rats with peroral threefold introduction of the compound in doses of 34 mg/kg (1/5 LD50) and in a dose of 1.7 mg/kg (1/100 LD50) for a space of 1, 3 and 6 months was investigated. It was found that gamma-HCCH penetrates the cells of the liver and brain and is non-uniformly distributed among subcellular fractions, viz. nuclear, mitochondrial and supernatant. Both in acute and chronic experiments the greatest amounts of the preparation were found in the nuclear fraction of the cell. The established features distinguishing the accumulation and distribution of the preparation in the subcellular fractions of the liver and brain explain the previously elicited biochemical and physiological shifts occurring in the organism after entrance of gamma-HCCH thereinto.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D001556:Hexachlorocyclohexane
Kharakter raspredeleniia gamma-geksakhlortsiklogeksana v subkletochnykh fraktsiiakh pecheni i mozga