Cell lines with spontaneous secretion of pregnancy-associated alpha 2-globulin.
Pregnancy-associated alpha 2-globulin (PA alpha 2G) was quantitated by radioimmunoassay in culture media from 34 exponentially growing human cell lines. Only 8/34 cell lines produced PA alpha 2G. The highest secretion was found in cell lines of histiocytic lymphoma origin while it was low in some carcinoma-derived lines. The results may support an assumption that PA alpha 2G is a normal cell product of B-lymphoid, monocytic and epithelial cells but may also simply indicate that ectopic PA alpha 2G production is especially common in tumors derived from such cells. The availability of PA alpha 2G-producing cell lines should facilitate studies of the immunoregulatory role of this protein.
D000510:Alpha-Globulins / Q000378:metabolism*; D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002460:Cell Line; D003470:Culture Media; D005260:Female; D006367:HeLa Cells / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000378:metabolism; D011863:Radioimmunoassay
D000510:Alpha-Globulins; D003470:Culture Media