Cancer-specific density changes in lymphocytes after stimulation with phytohaemagglutinin.
A fluorescence polarisation technique ("S.C.M. test") for detecting responses to phytohaemagglutinin revealed that the responsive lymphocytes from patients with malignant disease had an abnormal distribution after centrifugation through lymphocyte separation medium. In a small blind series the technique accurately distinguished patients with histologically proven malignancies from those with nonmalignant disease and normal people.
D000230:Adenocarcinoma / Q000175:diagnosis; D001249:Asthma / Q000175:diagnosis; D001943:Breast Neoplasms / Q000175:diagnosis; D001984:Bronchial Neoplasms / Q000175:diagnosis; D002291:Carcinoma, Papillary / Q000175:diagnosis; D018288:Carcinoma, Small Cell / Q000175:diagnosis; D002469:Cell Separation / Q000379:methods; D002499:Centrifugation, Density Gradient / Q000379:methods; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009369:Neoplasms / Q000175:diagnosis*; D003557:Phyllodes Tumor / Q000175:diagnosis; D010835:Phytohemagglutinins / Q000494:pharmacology; D012507:Sarcoidosis / Q000175:diagnosis; D013268:Stimulation, Chemical; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis
D010835:Phytohemagglutinins