title: Evidence for the involvement of the Na+-K+-ATPase in the mechanism of axonal protein and nucleoside transport.
abstract: [3H]Proline and [3H]uridine were injected into both eyes of the goldfish. 1 h before and after this injection 3X10)-6)M ouabain was administrated unilaterally to the retina. 8 h and 24 h after tracer injection the radioactivity in the retina, optic nerve and tectum was measured. It is suggested that the inhibition of the neuronal Na+-K+-ATPase inside the retina is responsible for the reduction of the labelled material transported into the optic nerve.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001370:Axonal Transport; D002531:Cerebellum / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006054:Goldfish; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011392:Proline / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D013477:Superior Colliculi / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D010042:Ouabain; D011392:Proline; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium; D014529:Uridine