Increase of contractile proteins in human cancer cells.
Human cells from skin and mammary-gland carcinomas show strong immunofluorescent staining with specific antibodies against smooth-muscle actin, myosin heavy meromyosin and light meromyosin, and contain numerous microfilaments as seen by electron microscopy. This increase in the amount of contractile proteins distinguishes cancer cells from the cells of normal tissues.
D000199:Actins / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D003285:Contractile Proteins / Q000378:metabolism*; D003599:Cytoskeleton / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D015879:Myosin Subfragments / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000378:metabolism
D000199:Actins; D003285:Contractile Proteins; D015879:Myosin Subfragments; D009363:Neoplasm Proteins; D009218:Myosins