Specific immune response genes of new inbred strains of guinea pigs.
Distribution of specific immune-response (Ir) genes controlling responsiveness to synthetic polypeptide antigens, homopolymer of poly-L-lysine (PLL), copolymer of L-glutamic acid and L-alanine (GA) and copolymer of L-glutamic acid and L-tyrosine (GT), and limiting doses of 2,4-dinitrophenyl guinea pig serum albumin  (DNP-GPA) was surveyed in new inbred strains of guinea pigs, JY 1, JY 2, JY 9  and JY 10, established in this Institute. The PLL gene was not found in any of the guinea pigs. The GA gene was found in JY 1 and JY 2 guinea pigs and the GT gene in all the guinea pigs. The gene controlling responsiveness to low doses (1 microgram) of DNP-GPA was found in JY 1, JY 9 and JY 10 guinea pigs. The associated (Ia) antigens was discussed.
D000818:Animals; D000939:Epitopes; D005796:Genes; D006168:Guinea Pigs / Q000235:genetics* / Q000276:immunology; D007178:Inbreeding
D000939:Epitopes