Deficient neutrophil function in a patient with chronic mucocutaneous candidiasis, thymoma and myasthenia gravis.
The case of a 68-year-old man who suffered the onset of chronic mucocutaneous candidiasis, thymoma, myasthenia gravis and a reversible neutrophil dysfunction during adult life is reported. All tests for humoral and cellular immunity proved normal. Thymectomy and the administration of transfer factor had no effect on the skin disease. Long-term oral administration of 5-fluorocytosine almost cleared the skin lesions; the neutrophil defect disappeared.
D000368:Aged; D002179:Candidiasis, Cutaneous / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D013945:Thymoma / Q000276:immunology*; D013953:Thymus Neoplasms / Q000276:immunology*