Effect of a single dose of dimethyl sulphoxide on renal amyloidosis.
An amyloid-like fibrillar substance was obtained under certain chemical conditions from the urine of 11 patients with amyloid nephropathy who had been given a test dose of dimethyl sulphoxide. This fibrillar material could not be produced in the urine from 9 patients with proteinuria due to other causes. This finding may be useful in the diagnosis of amyloid nephropathy and could lead to a new approach to thearpy.
D000284:Administration, Oral; D000682:Amyloid / Q000652:urine*; D000686:Amyloidosis / Q000175:diagnosis / Q000652:urine*; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine*; D051379:Mice; D011507:Proteinuria / Q000175:diagnosis*
D000682:Amyloid; D004121:Dimethyl Sulfoxide