title: Cell lines derived from teratocarcinomas.
abstract: A variety of cell lines have been isolated in vitro from transplantable teratocarcinomas. Some of them correspond to embryonal carcinoma (EC) cells. They are malignant and represent the stem cells from which all differentiated tissues derive in the tumor or in vitro. EC cells share some biochemical and antigenic properties with multipotential embryonic cells. From one of these EC cell lines, variants have been isolated in vivo and in vitro. Some are of EC type but restricted in their pattern of differentiation; others are altered in their tumorigenicity or in their antigenic characteristics. Another class of such variants corresponds to non-EC types. The most interesting ones correspond to tumoral lines of extra-embryonic tissues. All these cell lines constitute a valuable material for the study of mouse development and differentiation.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002449:Cell Aggregation; D002454:Cell Differentiation; D002460:Cell Line; D002869:Chromosome Aberrations; D046508:Culture Techniques / Q000379:methods; D005966:Glucuronidase / Q000378:metabolism; D006649:Histocompatibility Antigens; D007181:Inclusion Bodies, Viral; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism; D013724:Teratoma / Q000201:enzymology / Q000235:genetics / Q000382:microbiology; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens; D000509:alpha-Fetoproteins; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005966:Glucuronidase