Biochemical studies on RNA tumor virus information and its transmission in B16 murine melanoma.
The mouse melanoma B16 contains particles encapsulating a high molecular weight RNA of 60--70S size associated with a reverse transcriptase. The particles possess a density of 1.14--1.18 g/cm3. The RNA shares sequences with the 70S RNAs of several mammalian C-type RNA tumor viruses. The nuclear DNA of the mouse melanoma B16 possesses particle-related sequences not present in the genome of normal C57BL mice.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000378:metabolism; D008545:Melanoma / Q000382:microbiology*; D051379:Mice; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D012328:RNA Viruses / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012867:Skin / Q000032:analysis; D012878:Skin Neoplasms / Q000382:microbiology*
D004273:DNA, Neoplasm; D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase