title: Dietary fibre, transit-time, faecal bacteria, steroids, and colon cancer in two Scandinavian populations. Report from the International Agency for Research on Cancer Intestinal Microecology Group.
abstract: A comparison of dietary intake and faecal characteristics in population samples from two areas of Denmark and Finland with 4-fold variation in colon-cancer incidence suggests that the aetiology of colon cancer may be multifactorial and is not associated in a simple manner with dietary fat, neutral steroids, acid steroids, or their bacterial metabolites. However, meat consumption was greater in the high-incidence areas. Higher intakes of dietary fibre and milk in the low-incidence area suggest a possible protective effect, unrelated to mouth-anus transit-time. Further careful dietary and metabolic studies are needed to clarify the relationships between possible carcinogenic and protective effects of diet.
mesh_terms: D002482:Cellulose / Q000032:analysis*; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D003718:Denmark; D004034:Diet Surveys; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000032:analysis*; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005243:Feces / Q000032:analysis / Q000382:microbiology*; D005247:Feeding Behavior; D005260:Female; D005387:Finland; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology; D012424:Rural Population; D012621:Seasons; D013256:Steroids / Q000032:analysis*; D014505:Urban Population
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D013256:Steroids; D002482:Cellulose