[Inhibition of compound 48--80 induced histamine liberation from mast cells by triton X-100].
Triton X-100 at concentrations preceding those which liberated histamine, produced dose-dependent inhibition of compound 48/80-induced histamine release from rat mast cells. Triton X-100 (0.00002 1/1) depleted ATP content in the mast cells and blocked compound 48/80-induced histamine release. The inhibition of compound 48/80-induced histamine release and depletion of the ATP content in the mast cells was reversed by glucose (10 mmole). It is concluded that inhibition by Triton X-100 of histamine release induced by compound 48/80 is dependent on inhibition of energy production.
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000032:analysis / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors*
D011092:Polyethylene Glycols; D003189:p-Methoxy-N-methylphenethylamine; D000255:Adenosine Triphosphate
Tormozhenie tritonom X-100 vyzvannogo veshchestvom 48/80 vysvobozhdeniia gistamina iz tuchnykh kletok.