Antigenic changes of DBA/2J mastocytoma cells when grown in the BALB/c mouse.
A 10-day growth period of the DBA/2J strain-specific P815-X2 mastocytoma in the BALB/c mouse altered the antigenicity of the tumor cell surface. The in vivo-modified mastocytoma cells differed from mastocytoma cells grown in the original DBA/2J mice in suspectibility to lysis by immune peritoneal exudate cells, in vitro antigenic recognition by cytotoxic T-cells, and immunizing capacity in allogeneic C57BL/6 mice. Propagation of the altered tumor cells in the original host or maintenance in tissue culture for 40 hours restored complete susceptibility to lymphocyte-mediated cytotoxicity.
D000818:Animals; D000951:Antigens, Neoplasm; D001202:Ascitic Fluid / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006649:Histocompatibility Antigens; D007109:Immunity; D007930:Leucine / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology; D012515:Mast-Cell Sarcoma / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism; D013045:Species Specificity; D014184:Transplantation, Homologous
D000951:Antigens, Neoplasm; D000939:Epitopes; D006649:Histocompatibility Antigens; D007930:Leucine