title: [Quantitative behavior of eosinophil granulocytes in the bone marrow of children with acute lymphoblastic leukemia].
abstract: Of 31 children affected with acute lymphoblastic leukaemia the quantitative behaviour of eosinophilie granulocytes was examined in the course of the disease. Nearly all patients were treated according to a chemotherapy scheme (Memphis IV). During this therapy the eosinophils greatly diminished initially increased significantly to subnormal values and to the values of healthy persons with persisting full remission. Another significant decrease occurred during the relapse and in the pre-final stage. During each following relapse a greater diminution of bone-marrow eosinophils could be observed. Simultaneously the decrease of eosinophils led to a shift in the degree of maturation. In this connection the similar behaviour of neutrophilic and eosinophilic granulocytes of the bone-marrow must be stressed. Eventually, the lbast excrescence in the bone-marrow and its therapy cannot solely be decisive for the findings made. Relations to the lymphocytic system can be referred to.
mesh_terms: D001854:Bone Marrow Cells; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D015122:Mercaptopurine; D011241:Prednisone; D008727:Methotrexate
vernacular_title: Quantitatives Verhalten der eosinophilen Granulozyten im Knochenmark von Kindern mit akuter lymphoblastischer Leukose.