Eosinophilic spongiosis in early pemphigus foliaceus.
A case of widespread non-specific, itchy exanthema in a 74-year-old female is presented. An early skin biopsy showed eosinophilic spongiosis. Later a dermatitis herpetiformis-like eruption developed. However, immunofluorescence microscopy showed intercellular IgG deposits characteristic of pemphigus. Recognition of eosinophilis spongiosis may be helpful in differentiating early pemphigus from other bullous diseases.
D000328:Adult; D000368:Aged; D003874:Dermatitis Herpetiformis / Q000175:diagnosis; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D010392:Pemphigus / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology
D007074:Immunoglobulin G