Genetic polymorphism of the A subunit of human coagulation factor XIII.
Utilizing a fluorescent technique for the localization of transglutaminase activity after electrophoresis on thin layer agarose gels, we observed a new polymorphism of coagulation factor XIII in both platelets and plasma. The electrophoretic pattern was that of a dimeric protein. Homozygotes gave a single band, while heterozygotes presented a three banded pattern. The polymorphism was found to be due to variation of the A subunit. Data from Australian blood donors indicate that the A subunit of factor XIII has an autosomal locus.
D001315:Australia; D001782:Blood Donors; D004587:Electrophoresis, Agar Gel; D005176:Factor XIII / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000235:genetics; D013194:Staining and Labeling; D005723:gamma-Glutamyltransferase
D011498:Protein Precursors; D005176:Factor XIII; D005723:gamma-Glutamyltransferase