Inhibition of pancreas and gallbladder by pancreatic polypeptide.
Stimulated pancreatic and biliary outputs were studied in seven healthy subjects during intravenous infusion of bovine pancreatic polypeptide (P.P.) (mean dose 65 pmol/kg/h). P.P. significantly inhibited outputs of trypsin and bilirubin at plasma concentrations similar to those observed after meals. In four cholecystectomised subjects, P.P. inhibited only trypsin output.
D000328:Adult; D000368:Aged; D000818:Animals; D001639:Bicarbonates / Q000037:antagonists & inhibitors; D001663:Bilirubin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002417:Cattle; D004435:Eating; D005704:Gallbladder / Q000187:drug effects* / Q000503:physiopathology; D006728:Hormones / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors
D001639:Bicarbonates; D006728:Hormones; D014361:Trypsin Inhibitors; D010191:Pancreatic Polypeptide; D014357:Trypsin; D001663:Bilirubin