title: [Optimization of the nutrient medium makeup for the biosynthesis of bleomycine antibiotic using a mathematical method of experimental design].
abstract: The fermentation medium for bleomycin biosynthesis was optimized with the help of a mathematical method for experiment modelling. With the use of the schemes of orthogonal latin squares the optimal concentrations of the sources of nitrogen, carbon and mineral salts were determined and the negative effect of cupric sulphate on the antibiotic biosynthesis was shown. The antibiotic production on the developed medium was 3.7 times higher than that on the initial medium.
mesh_terms: D001761:Bleomycin / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008433:Mathematics; D012107:Research Design; D013306:Streptomycetaceae / Q000378:metabolism
chemical_list: D003470:Culture Media; D001761:Bleomycin
vernacular_title: Optimizatsiia sostava pitatel'noĭ sredy dlia biosinteza antibiotika bleomitsina s pomoshch'iu matematicheskogo metoda planirovaniia éksperimenta.