Immunological dissection of human Ia molecules.
The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000032:analysis* / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D003167:Complement Activation; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex
D000954:Antigens, Surface; D000939:Epitopes; D006680:HLA Antigens; D007519:Isoantigens; D046911:Macromolecular Substances