[Biogenic amine metabolism in homeotherms exposed to pesticides of different chemical nature].
Some aspects of the biogenic amines -- serotonin and histamine metabolism in rats and guinea pigs following introduction to them of pesticides of different chemical nature, viz. gamma-isomer of hexachlorcyclohexane (lindane) and dimethyldithiocarbamate zinc (zyram) were studied. These pesticides were found to dissimilarly affect the passage with urine of the principal serotonin metabolite -- 5-oxyindol-acetic acid. A short-term (2 days) introduction to rats of large doses (34 mg/kg) of lindane and a protracted (90 days) action of low doses (1.7 mg/kg) produce changes in the content of serotonin and of 5-oxyindol-acetic acid in the brain, liver and kidneys. In the blood of guinea pigs receiving for a lenthy time (120 days) small amounts (4 mg/kg) of zyram shifts in the histamine-histaminase-histaminopexy system were revealed, this pointing to the ability of this pesticide to provoke the state of sensitization.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D004125:Dimethyldithiocarbamate / Q000494:pharmacology*; D006168:Guinea Pigs; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D006632:Histamine / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013859:Thiocarbamates / Q000494:pharmacology*
D004125:Dimethyldithiocarbamate; D013859:Thiocarbamates; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001556:Hexachlorocyclohexane; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing)
Osobennosti obmena biogennykh aminov u teplokrovnykh pri vozdeĭstvii pestitsidami razlichnoĭ khimicheskoĭ prirody.