Pathological features of cantharidin-induced toxic cardiomyopathy: lack of correlation between electron-microscopic and histopathologic myocardial damage.
Electron-microscopic evidence of the cardiotoxic effects of cantharidin administered to rabbits was observed. No correlation was found between the electron-microscopic changes and the light-microscopic features as assessed by special histological stains. The reasons for this are discussed.
D000818:Animals; D002193:Cantharidin / Q000008:administration & dosage / Q000633:toxicity*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D009210:Myofibrils / Q000648:ultrastructure; D011817:Rabbits; D013194:Staining and Labeling
D002193:Cantharidin