Increased alpha-fetoprotein biosynthesis in rats following DL-ethionine and carbon tetrachloride injuries.
The incorporation of 14C-leucine into alpha-fetoprotein (AFP) in serum and liver extracts from DL-ethionine and carbon tetrachloride (CCl4)-injured rats was measured directly by using an immunochemical technique. The maximum value with nearly 10-fold increases of serum AFP was obtained in 3 days of both treatments. However, no significant increase in the immunoprecipitable AFP in liver extracts was detected under these conditions.
D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects*; D005001:Ethionine / Q000009:adverse effects*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000096:biosynthesis* / Q000302:isolation & purification
D000509:alpha-Fetoproteins; D002251:Carbon Tetrachloride; D007930:Leucine; D005001:Ethionine