Epidural morphine in treatment of pain.
Epidural injections of a 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior-horn cells of the spinal cord.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000698:Analgesia / Q000379:methods*; D002908:Chronic Disease; D004824:Epidural Space / Q000187:drug effects; D005260:Female; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D010146:Pain / Q000209:etiology; D010148:Intractable Pain / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy*; D011957:Receptors, Opioid / Q000187:drug effects; D013376:Substantia Gelatinosa / Q000187:drug effects
D011957:Receptors, Opioid; D009020:Morphine