Peripheral vascular disease in cigarette smokers and impaired hepatic metabolism of lipoprotein remnants.
The metabolism of very-low-density lipoproteins and chylomicrons includes the extrahepatic hydrolysis of their triglycerides by lipoprotein lipase. This results in cholesterol-rich "remnants" which are further metabolised by the liver. There is experimental evidence that in both patients with type-III hyperlipoproteinaemia and cigarette smokers hepatic-remnant metabolism may be depressed. In type-III hyperlipoproteinaemia the defect is inherited while in smokers it occurs in response to raised blood concentrations of carboxyhaemoglobin. The striking clinical similarity between type-III hyperlipoproteinaemic patients and smokers--namely, a high incidence of peripheral vascular disease--may be due to a common cause, the accumulation of cholesterol-rich remnants in the plasma.
D001161:Arteriosclerosis / Q000209:etiology*; D002263:Carboxyhemoglobin / Q000032:analysis; D002784:Cholesterol / Q000378:metabolism; D002914:Chylomicrons / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D006949:Hyperlipidemias / Q000150:complications* / Q000209:etiology; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D012907:Smoking / Q000150:complications*; D014280:Triglycerides / Q000378:metabolism
D002914:Chylomicrons; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002263:Carboxyhemoglobin; D002784:Cholesterol