Acute mouse and chronic dog toxicity studies of danthron, dioctyl sodium sulfosuccinate, poloxalkol and combinations.
Because of an apparent typographic error in a US patent, there has been some confusion as to the acute oral toxicity of danthron and danthron in combination with dioctyl sodium sulfosuccinate (DSS). Acute oral toxicity studies in mice revealed LD50 values of greater than 7 gm/kg for danthron, 2.64 gm/kg for DSS and 3.42 gm/kg for danthron/DSS mixture (1:2 ratio). These results indicate that the lethality of these compounds is in the gm/kg range and not in the mg/kg range. A one year chronic toxicity study of danthron, dioctyl sodium sulfosuccinate, poloxalkol and combinations in dogs failed to reveal any toxic effects. In particular, there was no evidence of hepatotoxicity or of any changes in the myenteric plexuses in the chronically treated dogs.
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002400:Cathartics / Q000633:toxicity*; D004143:Dioctyl Sulfosuccinic Acid / Q000633:toxicity*; D004285:Dogs; D004338:Drug Combinations; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D011060:Poloxalene / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000633:toxicity*; D013386:Succinates / Q000633:toxicity*; D013997:Time Factors
D000880:Anthraquinones; D002400:Cathartics; D004338:Drug Combinations; D013386:Succinates; D004143:Dioctyl Sulfosuccinic Acid; D011092:Polyethylene Glycols; D011060:Poloxalene; C004315:danthron