Suppression of chronic allergic encephalomyelitis: relevance to multiple sclerosis.
The expression of chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs was suppressed with a single series of injections of myelin basic protein in incomplete Freund's adjuvant. The suppression appeared permanent, and subsequent rechallenge with central nervous system antigen failed to elicit exacerbations.
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D007167:Immunotherapy; D007958:Leukocyte Count; D009103:Multiple Sclerosis / Q000628:therapy*; D004676:Myelin Basic Protein / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D004676:Myelin Basic Protein; D005620:Freund's Adjuvant