[Relations between urinary 3-methoxytyramine and the peripheral metabolism of dopamine in human adults and children].
3-Methoxytyramine (3-MT), the direct metabolite of dopamine (DA) is present in human urines at birth. The rate of its urinary excretion (microgram/24 h) increases highly from birth to 12 months of age; in the next period of infancy, the increase is slower and parallel to that of creatininury; after 15 years, the urinary amounts of 3-MT remain nearly constant, with advancing age. The analysis of the possible sources of urinary 3-MT, lead us to suggest that this compound has essentially a peripheral origin. On the other hand the comparison between urinary data of 3-MT and DA in normal infants and adult subjects has shown that 3-MT excretion is less affected by dietary input than DA itself, so that it can be concluded that urinary 3-MT is a better indication of peripheral dopaminergic activity than urinary DA, chiefly in the young child.
D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004298:Dopamine / Q000378:metabolism* / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014439:Tyramine / Q000031:analogs & derivatives* / Q000652:urine
D003404:Creatinine; C001746:3-methoxytyramine; D004298:Dopamine; D014439:Tyramine
Relations entre la 3-méthoxytyramine urinaire et le métabolisme périphérique de la dopamine chez l'homme et chez l'enfant.