HLA determinants in chronic active liver disease: possible relation of HLA-Dw3 to prognosis.
Thirty-eight patients with severe chronic active liver disease (CALD) were found to have a significantly higher frequency of HLA-Dw3 (68%) than 91 healthy controls (24%) (P less than 0;0001). The association of CALD was statistically significantly stronger with the D locus than with the B locus of HLA. The response to treatment was significantly worse in patients with HLA-Dw3 than in patients who lacked this antigen.
D000328:Adult; D002908:Chronic Disease; D000939:Epitopes; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000276:immunology*; D008297:Male
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens