title: Diurnal variations of plasma and pituitary thyrotrophin in adult male and female rats.
abstract: Male and female rats fed a low iodine diet for 20 days were used to study the diurnal variations in resting levels of plasma and pituitary TSH concentration using a highly sensitive radioimmunoassay. Sex differences in the fluctuations in plasma TSH levels and in amount of TSH in the pituitary gland were observed. The daily fluctuations of plasma TSH were characterized by two peaks that occurred in males at 6 a.m. and at 3 p.m. while in females the peaks were delayed until 9 a.m. and 7:30 p.m. Moreover, in the females the morning and the afternoon peaks were of the same intensity while in the males the afternoon peak that occurred just before the onset of darkness was much greater than the morning peak. There was a fall in TSH content of the pituitary in the male rats at 6 a.m. and also in the afternoon just before the onset of darkness. Thus, the diurnal variations in the plasma and pituitary TSH levels were related in male rats. In the females, however, the pituitary TSH concentration did not reflect the changes observed in the plasma TSH levels. The level of plasma PBI did not appear to be responsible for the fluctuations in plasma TSH concentration. It is suggested that the main mechanism for the control of the circadian rhythm of TSH might be related to a high activity at night.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004032:Diet; D005260:Female; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*
chemical_list: D013972:Thyrotropin