Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases.
It is suggested that the mechanism of muscle-cell necrosis in various muscle diseases is explained by an increased net influx of calcium into cells which triggers a "vicious cycle" of mitochondrial calcium overloading and energy depletion. If correct, this hypothesis may offer the basis of a more rational treatment of some muscle diseases even before their primary aetiology is known.
D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism*; D008954:Models, Biological; D009132:Muscles / Q000473:pathology*; D009136:Muscular Dystrophies / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D010085:Oxidative Phosphorylation
D002118:Calcium