Primary immune response of guinea pig spleen cells in vitro.
Spleen cells of the primed guinea pig, when cultured alone, failed to make a primary immune response against heterologous erythrocytes. When supplemented with lymphocytes obtained from mineral oil induced peritoneal exudate (PEL), a primary immune response against sheep, horse and chicken RBC was obtained. The kinetics, dose response and requirement of PELs for this response are reported.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D002645:Chickens; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D006736:Horses; D007111:Immunity, Cellular; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D000939:Epitopes; D014301:Trinitrobenzenes