[Selective action of novobiocin on Act. levoris, the producer of levorin and levoristatin].
The effect of sodium novobiocin on Act. levoris, strain LIA 0868 producing levorin and levoristatin was studied. High lethal effect of the antibiotic on Act. levoris was found. The effect increased with a rise in the antibiotic concentration in the agar from 2 to 6 lambda/ml. The inhibitory effect of novobiocin on Act, levoris was evident from a marked increase in the number of morphologically changed colonies with a low level of levorin production. The selective effect of novobiocin on the organism producing levorin and levoristatin was evident from selection of variants with high levels of levoristatin production on media containing novobiocin.
D000935:Antifungal Agents / Q000096:biosynthesis*; D002174:Candicidin / Q000096:biosynthesis*; D003470:Culture Media; D003609:Dactinomycin / Q000096:biosynthesis* / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D014644:Genetic Variation / Q000187:drug effects; D009675:Novobiocin / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism
D000935:Antifungal Agents; D003470:Culture Media; C008276:levoristatin; D002174:Candicidin; D009675:Novobiocin; D003609:Dactinomycin
Selektivnoe deĭstvie novobiotsina na produtsent levorina i levoristatina Act. levoris.