Detection and molecular characterization of the thymus-brain antigen in human brain.
Anti-human brain sera were found to contain antibodies reacting with determinants present on murine thymocyte plasma membranes. This determinant is borne by the thymocyte-brain antigen of mouse thymocytes. The non species-specific determinant of the thymocyte-brain system is detectable on the thymocyte-brain antigen of human and mouse brain in comparable amounts. In contrast to these findings, the allogenic Thy-1 and the species-specific determinant of this system were only found on the thymocyte-brain antigen of mouse brain but not on the corresponding antigen of human brain. The molecular weight, Stokes radius and diffusion coefficient of the thymocyte-brain antigen of human and mouse brain are in good accordance with the data estimated for the corresponding antigen of murine thymocytes.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D001921:Brain / Q000276:immunology*; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006801:Humans; D051379:Mice; D009928:Organ Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000939:Epitopes