title: Studies on the cutaneous sensitization reaction of guinea pigs to purified aromatic chemicals.
abstract: The sensitization reactions to purified cinnamic aldehyde and its chemically related substances were investigated using the maximization test on guinea pigs. Mutual cross-sensitivities were also examined. Cinnamic aldehyde was found to be the most potent sensitizer in this series, and a strong cross-sensitizer. From the chemical structures of these substances, the following speculations were made. There was a tendency that as the number of hydrocarbons of alkyl groups replacing the alpha-hydrogen in the molecule increased, the rate of sensitization reaction declined. The conjugated system of double bonds was suspected to be a determinant factor in relation to the sensitization ability of the substances in this series.
mesh_terms: D000447:Aldehydes / Q000276:immunology*; D000818:Animals; D002934:Cinnamates / Q000276:immunology*; D003429:Cross Reactions; D003877:Dermatitis, Contact; D006168:Guinea Pigs; D007114:Immunization; D008297:Male; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D013343:Styrenes / Q000276:immunology*
chemical_list: D000447:Aldehydes; D002934:Cinnamates; D013343:Styrenes