title: [Disorders of blood coagulatiion during haemoperfusion (author's transl)].
abstract: Charcoal haemoperfusion of patient may cause a fall in thrombocyte and fibrinogen levels. The possible cause of these changes in haemostasis was investigated by means of five haemoperfusion devices which were filled with 2000 ml ACD fresh blood and perfused for three hours. A continous reduction in the thrombocytes and the plasma coagulation proteins resulted, while the ethanol test and the level of fibrin degradation products stayed within normal levels. These results indicate the adsorption of thrombocytes and protein on to the surface of the charcoal haemoperfusion device. An activation of the coagulation system (i. e. disseminated intravasal coagulation, fibrinolysis) appears unlikely.
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D000991:Antithrombins / Q000032:analysis; D001772:Blood Cell Count; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000209:etiology*; D001792:Blood Platelets; D002091:Butyrylcholinesterase / Q000378:metabolism; D002606:Charcoal; D005169:Factor VIII / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D010958:Plasminogen / Q000032:analysis; D010974:Platelet Aggregation; D006435:Renal Dialysis / Q000009:adverse effects*; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000991:Antithrombins; D005338:Fibrin Fibrinogen Degradation Products; D000511:alpha-Macroglobulins; D002606:Charcoal; D000990:Antithrombin III; D005169:Factor VIII; D005340:Fibrinogen; D010958:Plasminogen; D002091:Butyrylcholinesterase
vernacular_title: Gerinnungsstörungen im Rahmen der Hämoperfusion