title: Thyroid-stimulating immunoglobulins do not cause non-autonomous, autonomous, or toxic multinodular goitres.
abstract: Thyroid-stimulating immunoglobulins (TSIs) were measured by radioreceptor assay in serum from 51 patients with a multinodular goitre, divided into four groups according to thyroid function, and in 30 normal people. In 9 patients who were euthyroid and had non-autonomous thyroid function and in 6 patients who were hyperthyroid, TSI index was normal . Of 21 euthyroid patients with autonomous function only 2 had a slightly abnormal TSI index (66 in both, normal greater than or equal to 68). Another series of 15 clinically euthyroid patients also had a normal TSI index. These results suggest that TSIs do not contribute to the pathogenesis of multinodular goitre, as has been suggested by others.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006044:Goiter, Nodular / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008135:Long-Acting Thyroid Stimulator / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay / Q000379:methods; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology* / Q000503:physiopathology
chemical_list: D007136:Immunoglobulins; D008135:Long-Acting Thyroid Stimulator