[Repeated, 2-10 fold asparaginase treatments in children with lymphoproliferative diseases].
In 42 children being in the advanced stage of an acute lymphoblastic leukaemia as well in 7 children with lymphosarcoma a total of 83 series of treatment with L-asparaginase were carried out. During the first blastic crisis of acute leukaemia 74% of complete or partial remissions could be obtained by two treatments and 52% by the following ones. The best results were obtained by organ manifestations of acute leukaemia (80% of complete or partial remissions). Less satisfactory results were achieved in treating lymphosarcoma. All remissions were only of a short duration.
D000293:Adolescent; D001215:Asparaginase / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D012075:Remission, Spontaneous; D013163:Splenomegaly / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy
D001215:Asparaginase
Mehrfache, 2- bis 10malige Asparaginase-Behandlung bei Kindern mit lymphoproliferativen Erkrankungen