title: Immunologic tolerance and immunopathology.
abstract: Immune tolerance has an antigen-directed specificity analogous to that of immune responsiveness. Studies have shown the direction of response-immunization or tolerization-is often dependent on the physical form and the dose of antigen, and that the two major lymphocyte classes, B cells and T cells, have different tolerance requirements. The critical relationships of these findings to autoimmunity are explored.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001323:Autoantibodies; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D003429:Cross Reactions; D000939:Epitopes; D007108:Immune Tolerance; D007136:Immunoglobulins; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB; D013601:T-Lymphocytes / Q000276:immunology; D013954:Thyroglobulin; D005719:gamma-Globulins
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001323:Autoantibodies; D000939:Epitopes; D007136:Immunoglobulins; D008070:Lipopolysaccharides; D005719:gamma-Globulins; D013954:Thyroglobulin