title: CSF circulation and blood-CSF barrier.
abstract: Results of microzone electrophoresis of non-concentrated CSF after staining with nigrosine and after evaluation on non-transparent acetate film are compared with those of isotope cisternography (111In-DTPA). We found that blood-CSF barrier disturbances begin with an increase of the absolute values of prealbumins in normal CSF circulation. When a barrier impairment occurs, by first increasing the absolute values of alpha1-globulins, we state a pathological CSF circulation. In this case, most of the globulin region is pathologic (globulin-type).
mesh_terms: D000418:Albumins / Q000134:cerebrospinal fluid; D000510:Alpha-Globulins / Q000134:cerebrospinal fluid; D001609:Beta-Globulins / Q000134:cerebrospinal fluid; D001798:Blood Proteins / Q000032:analysis*; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D004586:Electrophoresis; D006801:Humans; D009192:Myelography; D009468:Neuromuscular Diseases / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging; D011228:Prealbumin / Q000134:cerebrospinal fluid
chemical_list: D000418:Albumins; D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D011228:Prealbumin