Batrachotoxin inhibits axonal transport without affecting membrane potential in single neurons of Aplysia californica.
Intrasomatic injection of 0.25 ng of batrachotoxin (BTX) caused no depolarization of giant cerebral neurons (GCN) of Aplysia californica within 4 hr at 23 degrees C. The amplitude of action potential and the input resistance were slightly and reversibly decreased. The same dose of BTX caused a 68% inhibition of fast axonal transport.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia; D001370:Axonal Transport / Q000187:drug effects*; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D001496:Batrachotoxins / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
D001496:Batrachotoxins