[Chronobiological characteristics of the cytological indicators of the islands of Langerhans in mice].
This experimental work was conducted on 40 sexually mature albino mice; with the aid of cytometry and cytochemistry the 24-hour rhythm of functional activity of beta-cells of the pancreas was shown. An enlargement of the nuclei and nucleoli of beta-cells, an accumulation of specific fuchsinophilic and zinc-containing granules was noted at night (10 p.m.--6 a.m.); this pointed to the high functional activity of the insular cells at this time. During the day (10 a.m.--6 p.m.) the volume of the nuclei and nucleoli proved to decrease, and the specific granularity of beta-cells became less pronounced. Circadian rhythmicity of the insulin production by beta-cells was also indicated by the changed count of the insulin-containing blood erythrocytes.
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D002940:Circadian Rhythm; D004912:Erythrocytes / Q000032:analysis; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000166:cytology*; D007620:Karyometry; D008297:Male; D051379:Mice; D013194:Staining and Labeling
D007328:Insulin
Khronobiologicheskaia kharakteristika tsitologicheskikh pokazateleĭ insuliarnogo apparata podzheludochnoĭ zhelezy u mysheĭ.