Importance of experimental data for the improvement of the therapeutical effect of bleomycin.
The intimate mechanism of action of bleomycin has been extensively studied at molecular and cellular level. From the analysis of dose-response curves, different hypotheses have been formulated, and the importance and the extent of DNA repairability has been emphasized in correlation with the different phases of the cell cycle. Sensitivity to bleomycin depends on the fixation of DNA damage which occurs when damaged sites become involved in replication before they can be repaired.
D000818:Animals; D001483:Base Sequence; D001761:Bleomycin / Q000378:metabolism / Q000494:pharmacology*; D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects; D002477:Cells / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism; D004260:DNA Repair; D004351:Drug Resistance; D066298:In Vitro Techniques; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism; D009690:Nucleic Acid Conformation / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis
D001761:Bleomycin; D012313:RNA; D004247:DNA