[Release of prostaglandins and their precursors by bradykinin].
Bradykinin induces a release of unsaturated fatty acids and of prostaglandins from the perfused rat lung. This release is inhibited by chloroquine, a phospholipase A inhibitor. Histamine has no stimulating effect on fatty acids production. It is suggested that prostaglandins release induced by bradykinin might depend on a phospholipase activation.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins; D002738:Chloroquine; D001920:Bradykinin
Sur la libération des prostaglandines et de leurs précurseurs, par la bradykinine.