[Search for viral genetic information in human tumor DNA by means of transfection].
In embryonal human cell culture there was found the biological activity of DNA preparations, obtained from peripheral blood cells of acute leukemia patients, which was manifested in the production of virus-like RNA-containing particles, as evidenced by the radioisotope analysis findings and by the reverse transcriptase content in these particles. Also, a rapid growth of the cultures was noted. The DNA preparations from rhabdomyosarcoma, neurinoma and synovial sarcoma in man would cause only an enhancement of human embryonal cell cultures growth. No production of virus-like particles in the latter was noted.
D000328:Adult; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000235:genetics*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008168:Lung; D009369:Neoplasms / Q000235:genetics*; D009442:Neurilemmoma / Q000235:genetics; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012190:Retroviridae / Q000235:genetics*; D012208:Rhabdomyosarcoma / Q000235:genetics; D012509:Sarcoma / Q000235:genetics; D013584:Sarcoma, Synovial / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics; D013997:Time Factors; D014162:Transfection
D004273:DNA, Neoplasm; D012194:RNA-Directed DNA Polymerase
Poiski virusogeneticheskoĭ informatsii v DNK opukholeĭ cheloveka metodom transfektsii.