Antimicrobial action of compound 48/80 against protozoa, bacteria, and fungi.
Compound 48/80 inhibited the growth of protozoa, bacteria, and fungi but had no effect on the multiplication of viruses. All susceptible organisms were inhibited by 10 microgram/ml of crude compound 48/80, and some were inhibited by as little as 0.1 microgram/ml. Against Tetrahymena pyriformis, this drug was seven times more potent than quinine. Separation of compound 48/80 into different fractions indicated that some antimicrobial activity could be separated from the histamine-liberating activity. It was found that compound 48/80 is not surface active at 500 microgram/ml.
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002850:Chromatography, Gel; D056890:Eukaryota / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013500:Surface Tension; D014780:Viruses / Q000187:drug effects; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D003189:p-Methoxy-N-methylphenethylamine