Influence of boar acrosin antibodies produced in rabbit and sheep on chymotrypsinogen activation catalyzed by acrosin from boar, bull, ram, rabbkt and human.
Activation of bovine chymotrypsinogen is catalyzed with increasing velocity by human, rabbit, boar, bull and ram acrosin. Antiboar-acrosin rabbit gamma-globulins cause a significant reduction in the proenzyme activation rate induced by boar and bull acrosin, but only a weak reduction or none if ram or rabbit acrosin is the activating agent. The antiboar-acrosin gamma-globulins from sheep strongly inhibit chymotrypsinogen activation by ram, bull and boar acrosin, and significantly inhibit the human acrosin-catalyzed reaction.
D000176:Acrosin / Q000276:immunology* / Q000494:pharmacology; D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D002417:Cattle; D002919:Chymotrypsinogen / Q000378:metabolism*; D010450:Endopeptidases / Q000276:immunology*; D004789:Enzyme Activation; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D014361:Trypsin Inhibitors; D005719:gamma-Globulins / Q000494:pharmacology
D000906:Antibodies; D007074:Immunoglobulin G; D014361:Trypsin Inhibitors; D005719:gamma-Globulins; D002919:Chymotrypsinogen; D010450:Endopeptidases; D000176:Acrosin