Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing n-glycolylneuraminic acid.
Gangliosides that possess the same sugar sequence but differing in the type of sialic acid (N-acetyl- or N-glycolylneuraminic acid) were compared for their reactivity with Hanganutziu-Deicher ('serum sickness') antibodies by double-diffusion gel precipitation tests. Only N-glycolylneuraminic acid containing gangliosides formed precipitation lines with Hanganutziu-Deicher antibodies, thus suggesting that Hanganutziu-Deicher antigens are gangliosides that contain N-glycolylneuraminic acid.
D000918:Antibody Specificity; D000941:Antigens; D000939:Epitopes; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D012713:Serum Sickness / Q000276:immunology*; D012794:Sialic Acids
D000941:Antigens; D000939:Epitopes; D005732:Gangliosides; D012794:Sialic Acids