[Exocrine function of the pancreas under the effect of different doses of hexachlorocyclohexane].
Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Of a prolonged action of relatively small doses of HCCH (1/20 and 1/50 DL50) is characteristic an initial inhibition and subsequent stimulation of the exosecretory function of the pancreas. A definite inverse relation between the amount of the introduced HCCH dose and the duration of the pancreatic inhibition period was noted.
D000681:Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010179:Pancreas / Q000201:enzymology* / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors; D051381:Rats
D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D001556:Hexachlorocyclohexane; D008049:Lipase; D000681:Amylases; D010447:Peptide Hydrolases
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