[Intraarterial bleomycin therapy on squamous cell carcinomas of the oral cavity. Clinico-pathological investigations (author's transl)].
The mode of action of bleomycin after intraarterial perfusion in 53 patients with advanced squamous cell carcinoma of the oral cavity is reported on the basis of clinical results and pathologico-anatomic findings. In 29 out of 32 cases not previously treated a clinically complete remission could be achieved by primary chemotherapy. In 8 cases these findings were histomorphologically confirmed and 7 patients have shown a persistant remission for 9 to 61 months. The chances of success are much less favorable in the treatment of recurrences. No clinical advantages were observed when combining bleomycin with other chemotherapeutics.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D006801:Humans; D007269:Injections, Intra-Arterial; D008168:Lung / Q000187:drug effects / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D012039:Regional Blood Flow; D014652:Vascular Diseases / Q000139:chemically induced
D000970:Antineoplastic Agents; D001761:Bleomycin
Intraaterielle Bleomycintherapie von Plattenepithelcarcinomen der Mundhöhle. Klinik und pathologische Anatomie