Evidence for the presence of choleragen receptor on the thymocyte-brain antigen molecule of mice.
CBA thymocytes were subjected to cocapping experiments using AThy-1.2 and choleragen. The finding that both structures showed a common ligant-induced redistribution implies that choleragen receptors of the cell membrane are associated with the thymocyte-brain molecule. Furthermore, it was found that the thymocyte-brain antigenic determinants on the thymocyte were not blocked by prior choleragen treatment. This suggests a spatial distance between these structures on the molecule.
D000818:Animals; D001666:Binding Sites, Antibody; D001921:Brain / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D004768:Enterotoxins; D000939:Epitopes; D051379:Mice; D011955:Receptors, Drug; D013601:T-Lymphocytes / Q000276:immunology*; D014733:Vibrio
D004768:Enterotoxins; D000939:Epitopes; D011955:Receptors, Drug