[Comparison of the effect of acetone and isopropanol on lipid metabolism in rats].
Isopropanol and acetone administered to rats in conditions leading to a similar blood acetone level differ markedly in their effects on lipid metabolism. Isopropanol administration determines a fatty liver, which is mainly related to a defect in hepatic lipoprotein synthesis. Acetone administration gives only raise to a slight increase in the liver triacylglycerol level. It does not alter the [1-14C] palmitate, [1-14C] glycerol or [U-14C] leucine incorporation into blood lipoproteins. Acetone does thus not appear to play a preminent role in the isopropanol induced fatty liver which seems to be related mainly to a direct action of the alcohol itself.
D000433:1-Propanol / Q000494:pharmacology*; D000096:Acetone / Q000494:pharmacology*; D000818:Animals; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D000096:Acetone; D000433:1-Propanol
Etude comparative des actions de l'acétone et de l'isopropanol sur le métabolisme lipidique chez le rat.