[Effect of heparin, heparin derivatives and heparinoids on blood sugar levels of diabetes mellitus patients].
The effect of heparin, its derivatives--sodium iodoheparinate (dioparin), diethylaminoethyltheophylline heparinate (milheparin), and also heparinoids--eleparon, "thrombo" Goltzinger and Sp-51 degrees on the blood sugar level in patients with diabetes mellitus and in healthy persons was studied. The preparations were administered by drop intravenous infusion for 4 hours in a dose corresponding to 10 000 U of heparin activity. Glycemia, lipoproteid lipase, blood lipid fractions, and blood endogenous heparin levels were studied before and after the drug administration. In diabetic patients these preparations decreased the blood sugar level and effected the blood lipid fractions level. Potential mechanisms of the influence on the blood sugar level are discussed; four action mechanisms are assumed--the effect on insulin secretion and on the sensitivity to it, the effect on the liver, on disturbances of fat metabolism, and on increase of glucose use in the peripheral tissues.
D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D002809:Chondroitin Sulfates / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006493:Heparin / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D006496:Heparinoids / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use; D010743:Phospholipids / Q000097:blood; D013806:Theophylline / Q000031:analogs & derivatives / Q000627:therapeutic use
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006496:Heparinoids; D007004:Hypoglycemic Agents; D008055:Lipids; D010743:Phospholipids; D010426:Pentosan Sulfuric Polyester; D006493:Heparin; D002809:Chondroitin Sulfates; D002784:Cholesterol; D013806:Theophylline; D008071:Lipoprotein Lipase
Vliianie geparina, geparinovykh proizvodnykh i geparinoidov na uroven' sakhara v krovi u bol'nykh sakharnym diabetom.