Increased unsaturated transcobalamin II in active autoimmune disease.
Measurements of transcobalamin II (T.C. II) concentrations in 26 patients with lupus erythematosus, 4 with dermatomyositis, 2 with autoimmune haemolytic anaemia, and in 40 immunosuppressed renal-transplant patients showed that T.C. II levels were raised during active phases of autoimmune disease. Changes in T.C. II levels correlated better with the clinical course of autoimmune disease than did changes in C3, the titre of antinuclear antibody, or native D.N.A.-binding capacity.
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology; D001798:Blood Proteins / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D003882:Dermatomyositis / Q000097:blood / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D014155:Transcobalamins / Q000032:analysis* / Q000276:immunology; D014184:Transplantation, Homologous
D001798:Blood Proteins; D003176:Complement C3; D014155:Transcobalamins