Haematological changes in experimental hydralazine-induced collagen-like syndrome in guinea pigs.
Haematological studies were carried out in hydralazine-induced collagen-like syndrome in guinea pigs. 37.5 per cent of animals were found to be LE-positive. It was found that long-term administration of hydralazine caused a decrease of erythrocyte count, a decrease of haemoglobin concentration and a decrease of haemoglobin content in individual red blood cell as well as a decrease of a single erythrocyte volume. A significant leukopenia was shown in LE-positive subgroup of hydralazine-treated guinea pigs. The obtained results confirmed the similarity of hydralazine syndrome to systemic lupus erythematosus.
D000818:Animals; D002452:Cell Count; D003095:Collagen Diseases / Q000097:blood* / Q000139:chemically induced; D004912:Erythrocytes; D006168:Guinea Pigs; D006400:Hematocrit; D006454:Hemoglobins; D006830:Hydralazine; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D051379:Mice; D009504:Neutrophils
D006454:Hemoglobins; D006830:Hydralazine