Auto anti-Kpb associated with weakened antigenicity in the Kell blood group system: a second example.
An 84-year-old woman with intestinal bleeding had marked reduction of red blood cell antigenicity in the Kell system, and a positive direct antiglobulin test caused by auto-anti-Kpb. KX antigen activity of her cell was increased, an observation which supports the belief that KX marks a precursor structure utilized in the normal Kell biosynthetic pathway. It is postulated that reduced Kell antigenicity was an acquired change that resulted from enzymatic degradation, possibly of bacterial origin.
D000293:Adolescent; D000368:Aged; D001323:Autoantibodies; D001789:Blood Group Antigens; D000939:Epitopes; D005260:Female; D006801:Humans; D007626:Kell Blood-Group System; D008297:Male
D001323:Autoantibodies; D001789:Blood Group Antigens; D000939:Epitopes; D007626:Kell Blood-Group System