[Electrophysiological study of latent neuropathies induced by perhexiline].
The aim of this study was to estimate the frequency of latent perhexiline-induced neuropathy in man. Several electrophysiological parameters were recorded and compared between a control group and a group of treated patients, without clinical evidence of neuropathy. The Hmax/Mmax amplitude ratio of the soleus H reflex was decreased in 2/3 of the patients. The H reflex latency was increased in 1/3 of them. The distal motor latencies of ulnar and popliteal nerves were increased in 1/4 of them. Only 1/3 of the patients treated did not show any electrophysiological abnormality. The validity of these results and the possible mechanisms involved are discussed.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D004558:Electric Stimulation; D005071:Evoked Potentials; D006181:H-Reflex; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction; D010480:Perhexiline / Q000009:adverse effects* / Q000627:therapeutic use; D010525:Peripheral Nerves / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010880:Piperidines / Q000009:adverse effects*
D010880:Piperidines; D010480:Perhexiline
Etude électrophysiologique des neuropathies latentes induites par la perhexiline.