Hyperviscosity syndrome attributable to hyperglobulinemia in chronic active hepatitis.
A young women with clinical and histological features of chronic active hepatitis was noted to have extremely high levels of immunoglobulin (14.6 g per dl). This was associated with the hyperviscosity syndrome, diffuse coagulation abnormalities, and renal insufficiency in the absence of severe liver disease. Correction of these features occurred with plasmapheresis before corticosteroid therapy was begun. A similar group of persons with very high gamma-globulin levels, described previously under the heading of "plasma cell hepatitis," may form a distinct and rare subgroup of chronic active hepatitis patients.
D000293:Adolescent; D001219:Aspartate Aminotransferases / Q000097:blood; D001707:Biopsy, Needle; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000209:etiology; D008099:Liver / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D010956:Plasmapheresis; D013577:Syndrome; D008258:Waldenstrom Macroglobulinemia / Q000150:complications; D005719:gamma-Globulins
D005719:gamma-Globulins; D001219:Aspartate Aminotransferases