Problems relating to immunoselection of leukemias.
Problems relating to immunoselection of neoplastic, in particular leukemic, cell lines are reviewed. Since there is ample evidence that specific immune reactions of the host against malignant neoplastic cells do occur, it becomes important to consider the effectiveness and the relevance of immunity in suppression or elimination of neoplastic growth. Emphasis is placed on experimental results obtained in syngeneic tumor-host combinations, because they more closely resemble the situation of spontaneous tumorigenesis or leukemogenesis than xenogeneic or allogeneic model systems. Studies of types of neoplasia observed in cases of human immunodeficiency syndromes offer an important insight into problems involved in immunoselection of leukemic cell lines: the marked predominance of leukemias and lymphoreticular neoplasias in immunodeficient patients invites speculation on both the mechanisms of leukemogenesis and the relative importance of the immune system in eliminating malignant neoplastic cells.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D002999:Clone Cells; D004195:Disease Models, Animal; D000939:Epitopes; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007938:Leukemia / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude
D000939:Epitopes