[Effect of actinomycin D, carminomycin and bleomycin and their joint use with serotonin and zymosan on the functional state of the peritoneal macrophages].
The study of the effect of actinomycin D, karminomycin and bleomycin used alone or in combination with zimozan or serotonine on the functional state of the peritoneal macrophages showed that the use of the antibiotics in mice without tumors induced a decrease mainly in the absorptive capacity of the macrophages not changing significantly their digestive activity. The same antibiotics did not significantly change the initial low values of the functional activity of the cells in mice with transplantable tumors. The use of zimozan after completeness of the treatment course with actinomycin D, karminomycin and bleomycin in mice without tumors had a stimulating effect on the functional activity of the macrophages. Zimozan had a stimulating effect on the functional activity of the cells in mice with transplantable tumors only on its use after completeness of the treatment course with actinomycin D or bleomycin. Serotonine in combination with the above antibiotics had no stimulating effect on the functional activity of macrophages in mice both with and without tumors.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use*; D002360:Carubicin / Q000627:therapeutic use*; D003609:Dactinomycin / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010529:Peritoneal Cavity / Q000166:cytology*; D010587:Phagocytosis / Q000187:drug effects; D012701:Serotonin / Q000627:therapeutic use*; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D015054:Zymosan / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D004338:Drug Combinations; D001761:Bleomycin; D003609:Dactinomycin; D012701:Serotonin; D015054:Zymosan; D002360:Carubicin
Vliianie aktinomitsina D, karminomitsina i bleomitsina i ikh sochetannogo primeneniia s serotoninom i zimozanom na funktsional'noe sostoianie peritoneal'nykh makrofagov.