B and T cell markers of bone marrow and peripheral blood lymphoid cells in patients with paraproteinaemia.
Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D003176:Complement C3 / Q000032:analysis; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D009101:Multiple Myeloma / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D003176:Complement C3; D000939:Epitopes; D007136:Immunoglobulins