Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension.
Continuous recording of intra-arterial blood pressure in 11 ambulant patients taking postganglionic blocking drugs for the treatment of hypertension has shown an alternating pattern of high pressures at rest and very low pressures associated with exertion during normal daily activities. In 4 patients there was evidence of decreased cerebral or myocardial blood-flow during hypotensive episodes. It is suggested that these agents may predispose towards cerebral and myocardial infarction.
D000328:Adult; D000368:Aged; D001627:Bethanidine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D003647:Debrisoquin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006145:Guanethidine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006146:Guanidines / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D007546:Isoquinolines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011674:Pulse / Q000187:drug effects; D012146:Rest
D006146:Guanidines; D007546:Isoquinolines; D001627:Bethanidine; D003647:Debrisoquin; D006145:Guanethidine