Serum-derived immunosuppressive substances. III. Regulation of the immune response by human serum alpha-globulin fractions: the dose-response relationship.
Suppression of the plaque-forming cell response in mice following injection of substances fractionated from pooled normal serum alpha-globulin was investigated. The dose-response relationship for fractions obtained by ion-exchange chromatography show that a single preparation has both enhancing and suppressive activities which are revealed at different doses. Whether this observation reflects the sum of activities of a number of molecular species remains to be determined. The immune responses to both thymus-dependent (heterologous erythrocytes) and thymus-independent (DNP-ficoll) antigens are suppressed while the response to the thymus-independent antigen lipopolysaccharide is enhanced. Thus, the cellular locus for immunosuppression cannot be exclusively on the T cell, and the magnitude of the action of the two populations (T and B cells) remains unclear.
D000510:Alpha-Globulins / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D004136:Dinitrobenzenes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005362:Ficoll / Q000276:immunology; D006041:Goats; D006462:Hemolytic Plaque Technique; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008070:Lipopolysaccharides / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008805:Mice, Inbred A
D000510:Alpha-Globulins; D004136:Dinitrobenzenes; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D005362:Ficoll