Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A.
Cyclosporin A was given to pigs receiving orthotopic cardiac allografts from donors mismatched at the major locus. Median survival in 20 control pigs was only 6 days; in 5 pigs given cyclosporin A at 15 mg/kg on 3 days median survival was 22 days; and when 6 animals were given 25 mg/kg intramuscularly for 2 days and then orally median survival is greater than 68 days, with 4 animals still alive.
D000284:Administration, Oral; D000818:Animals; D005656:Fungal Proteins / Q000008:administration & dosage*; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D003904:Mitosporic Fungi; D010456:Peptides, Cyclic / Q000008:administration & dosage*; D013170:Spores; D013552:Swine; D013997:Time Factors; D014184:Transplantation, Homologous; D014242:Trichoderma
D005656:Fungal Proteins; D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic