[Expression of C-type oncornavirus proteins in tumors of CC57BR mice].
Murine endogenous oncornavirus (C-type) genome expression was investigated in methylcholanthrene-induced (MC-induced) tumours of low-leukemic CC57BR mice by means of the radioimmunodiffusion method, using the precipitating test-systems. The gs-1 antigen of murine C-type viral p30 protein and Gross leukemia virus type-specific antigen (AGLV) served as viral genome markers. The gs-1 antigen was found in the primary and continuous MC-induced sarcomas, whereas AGLV appeared only during the tumour passage. A distinct association was revealed between the quantity of p30 protein (gs-1 antigen titre) and the presence of AGLV. Simultaneously with the appearance of AGLV the gs-1 titre increased markedly and the AGLV disappearance was always accompanied by a decrease of the gs-1 titre. The data presented suggest a coordinated expression of the two investigated proteins of murine C-type endogenous oncornaviruses in the chemically-induced tumours of CC57BR mice.
D000406:AKR murine leukemia virus; D000818:Animals; D000951:Antigens, Neoplasm / Q000302:isolation & purification; D000956:Antigens, Viral / Q000302:isolation & purification; D000939:Epitopes; D005814:Genes, Viral; D051379:Mice; D008815:Mice, Inbred Strains; D012190:Retroviridae; D012513:Sarcoma, Experimental / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins
Vyrazhenie belkov onkornavirusov C-tipa v opukholiakh mysheĭ CC57BR.