Increased hepatic copper concentration in Indian childhood cirrhosis.
19 Indian children with liver disease were studied. 5 in whom a clinical and histological diagnosis of Indian Childhood Cirrhosis was made had massive orcein-staining deposits in liver cells. The hepatic copper content in these 5 cases was strikingly high (1389 microgram/g dry tissue, range 1045--2303) the normal range being 15--55 microgram/g. Of the other 14 cases, only 2 had hepatic copper levels above normal (170 and 262 microgram/g.) This high hepatic copper concentration may be caused by excessive copper ingestion or an abnormality of copper metabolism.
D004396:Coloring Agents; D003300:Copper / Q000032:analysis / Q000378:metabolism* / Q000506:poisoning; D006801:Humans; D007194:India; D007223:Infant; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008664:Metal Metabolism, Inborn Errors / Q000150:complications; D010078:Oxazines; D013194:Staining and Labeling / Q000379:methods
D004396:Coloring Agents; D010078:Oxazines; C002313:PAcein; D003300:Copper