The origin of serum protein, A, B, and H blood group, and Gm and Inv antigens in house dust.
Materials precipitated from an aqueous extract of house dust by saturation with ammonium sulphate showed immunological reaction with antisera to human serum albumin, human alpha1-acid glycoprotein, human IgG, Gm and Inv antigens and to A, B and H antigens. It is concluded that the albumin and alpha1-acid glycoprotein are of human origin. It seems that the apparent IgG activity is due to cross-reactivity since, from the anticipated specificities of the Fab and Fc fragments of human IgG, the former could not be detected, and since Gm (6) activity was present, unexpectedly, in Swiss house dust. The A, B and H blood group antigenic activities were detected in relative concentration different from those expected if they were solely of human origin. It is concluded that they are from both human and non-human sources.
D000017:ABO Blood-Group System; D001798:Blood Proteins / Q000032:analysis* / Q000276:immunology; D004391:Dust / Q000032:analysis*; D000939:Epitopes; D006385:Hemagglutination Inhibition Tests; D007106:Immune Sera; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments / Q000032:analysis; D007141:Immunoglobulin Fc Fragments / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007202:Indicators and Reagents; D012463:Saliva / Q000276:immunology
D000017:ABO Blood-Group System; D001798:Blood Proteins; D004391:Dust; D000939:Epitopes; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007202:Indicators and Reagents