title: Detection and possible functional influence of antibodies directed againt the pancreatic islet cell surface.
abstract: Antibodies directed towards determinants on the surface of rat islet cells can be detected qualitatively by the indirect immunofluorescence or quantitatively by a specific radioassay for IgG. Antibodies are found in insulin-dependent diabetics or in rabbits immunized with islet cells. Such antibodies may affect the B-cell function as indicated by the inhibition of incorporation of radioactive leucine into proinsulin/insulin in vitro.
mesh_terms: D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D007074:Immunoglobulin G; D007328:Insulin / Q000096:biosynthesis; D007515:Islets of Langerhans / Q000276:immunology* / Q000378:metabolism; D051381:Rats
chemical_list: D000906:Antibodies; D000954:Antigens, Surface; D000939:Epitopes; D007074:Immunoglobulin G; D007328:Insulin