Acid-phosphatase reaction in acute lymphoblastic leukaemia.
The diagnostic value of the acid-phosphatase reaction was assessed double-blind in 148 cases of acute lymphoblastic leukaemia (A.L.L.) classified by surface-membrane markers and entered into the M.R.C. U.K. A.L.L. trials. 90% of cases of T-A.L.L. showed a positive reaction in the majority of blast cells, while only 2% of common-A.L.L. and 10% of null-A.L.L. were positive. This cytochemical reaction distinguished the more aggressive form of A.L.L. any may aid the choice of therapy.
D000135:Acid Phosphatase; D001402:B-Lymphocytes / Q000473:pathology; D002462:Cell Membrane / Q000201:enzymology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006651:Histocytochemistry; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood / Q000175:diagnosis*; D010641:Phenotype; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology
D000135:Acid Phosphatase