Effect of myo-inositol on peripheral-nerve function in diabetes.
myo-Inositol, 500 mg twice a day, given to seven diabetic patients for two weeks, increased the amplitude of the evoked action potentials of the median, sural, and popliteal nerves by an average of 76%, 160%, and 40%, respectively. There was no significant change in the conduction velocities of these nerves, myo-Inositol may be valuable in the treatment of diabetic neuropathy.
D000368:Aged; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007294:Inositol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008160:Lumbosacral Plexus / Q000503:physiopathology; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects* / Q000503:physiopathology; D010919:Placebos; D013497:Sural Nerve / Q000503:physiopathology
D010919:Placebos; D007294:Inositol