Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis.
The syntheses and structure--activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are both antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy(-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring, 168, 171, 173, and 174.
D015110:4-Hydroxycoumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006636:Histamine Release / Q000187:drug effects*; D008722:Methods; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D015110:4-Hydroxycoumarins; D013189:SRS-A