On the induction of the hepatic tyrosine aminotransferase by quinolinic acid.
The induction of tyrosine aminotransferase by quinolinic acid is inhibited completely by cycloheximide and by alpha-amanitin, but only partially during the first 3 hours by 5-azacytidine and 8-azaguanine; longer treatment with 8-azaguanine, however, also prevents the major increase in enzyme activity. The hepatic concentration of cyclic AMP does not change after administration of quinolinic acid. Insulin, like hydrocortisone, acts additively to qlinolinic acid. The isoenzyme pattern of tyrosine aminotransferase is not changed cosniderably during induction of quinolinic acid. Most likely, quinolinic acid acts through its own mechanism of induction.
D000546:Amanitins / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D014444:Tyrosine Transaminase / Q000096:biosynthesis
D000546:Amanitins; D011725:Pyridines; D011805:Quinolinic Acids; D003513:Cycloheximide; D000242:Cyclic AMP; D014444:Tyrosine Transaminase