The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro.
A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DSCG as an inhibitor of histamine release by antigen from actively and passively sensitized rat peritoneal cells and rat skin fragments.
D000818:Animals; D000941:Antigens; D002478:Cells, Cultured; D004205:Cromolyn Sodium / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D007192:Indenes / Q000627:therapeutic use*; D007962:Leukocytes / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D013189:SRS-A / Q000378:metabolism*; D012867:Skin / Q000187:drug effects
D000941:Antigens; D007189:Indans; D007192:Indenes; D013189:SRS-A; C012136:nivimedone; D004205:Cromolyn Sodium