title: Acquired lipidosis of marrow macrophages: birefringent blue crystals and Gaucher-like cells, sea-blue histiocytes, and grey-green crystals.
abstract: Three varieties of compound lipid inclusions occurring as a secondary phenomenon in marrow macrophages are detectable and distinguishable by Romanowsky staining, ultraviolet fluorescence, and polarised light. Birefringent blue crystals and Gaucher-like cells form one variety, sea-blue granules another, and grey-green crystals a third. All occur chiefly in myeloid leukaemias, either acute or chronic.
mesh_terms: D001718:Birefringence; D001853:Bone Marrow / Q000378:metabolism*; D005776:Gaucher Disease / Q000473:pathology; D006644:Histiocytes / Q000378:metabolism / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000648:ultrastructure; D050356:Lipid Metabolism; D008264:Macrophages / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008859:Microscopy, Polarization; D008860:Microscopy, Ultraviolet; D013194:Staining and Labeling