title: Changes in synaptic function induced by blockage of axonal transport in the rabbit optic pathway.
abstract: This study was undertaken to elucidate the physiological significance of material involved in the rapid axonal transport. The effects of colchicine-induced inhibition of axonal transport in the retinal ganglion cells on the electrophysiological properties of the retrobulbar visual pathways were investigated in Albino rabbits. An impaired signal transmission to the contralateral visual cortex, superior colliculus and lateral geniculate body following flash light stimulation as well as direct optic nerve stimulation appeared 4--6 days after an intravitreous injection of 10--25 microgram colchicine. It was concluded that inhibition of the fast axonal transport within the retinal ganglion cells interferes with transsynaptic signal transmission from optic nerve terminals in the subcortical nuclei. This indicates a functional relationship between material supplied via the rapid phase of axonal transport and an unimpaired transsynaptic signal transmission, previously not revealed in the central nervous system of mammals.
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology; D004558:Electric Stimulation; D004594:Electrophysiology; D007839:Functional Laterality; D005724:Ganglia / Q000502:physiology; D005829:Geniculate Bodies / Q000502:physiology; D009411:Nerve Endings / Q000502:physiology; D009900:Optic Nerve / Q000502:physiology; D010775:Photic Stimulation; D011817:Rabbits; D012160:Retina / Q000166:cytology; D013477:Superior Colliculi / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology*
chemical_list: D003078:Colchicine