Dihydrotestosterone-binding protein in cytosols of normal and hypertrophic human prostates, and influence of estrogens and anti-androgens on the binding.
Dihydrotestosterone-binding protein was observed in cytosols of the normal and hypertrophic human prostates. Association constant for dihydrotestosterone of cytosol of the normal prostate differed slightly from that of the hypertrophic prostate. However, maximum binding capacity was almost identical in these tissues. No distinct correlation was detected between proportion of glandular constituent and binding characteristics (Ka and maximum binding capacity) in the hypertrophic prostates. Influence of some steroids on the binding with dihydrotesterone was examined. Testosterone, estradiol-17beta, estriol, cyproterone acetate and SK & F 7690 inhibited the binding competitively. However, Sch 13521 did not exhibit any influence on the binding.
D001667:Binding, Competitive; D003600:Cytosol / Q000032:analysis / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011467:Prostate / Q000032:analysis / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011485:Protein Binding; D013739:Testosterone / Q000494:pharmacology
D004967:Estrogens; D006727:Hormone Antagonists; D013196:Dihydrotestosterone; D013739:Testosterone