HLA determinants in idiopathic hemochromatosis.
HLA-A and B antigens were defined in 154 unrelated idiopathic hemochromatosis patients. The study confirmed the highly significant positive association with HLA antigens A3 (corrected P less than 10(-10)) and B14 (corrected P less than 10(-9)). HLA-DR typing showed increased frequency of the specificity DRw6, which was frequently associated with the phenotype A3, B14 and antigen B14, suggesting linkage disequilibrium. This was borne out by PLT data.
D000939:Epitopes; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000032:analysis; D006432:Hemochromatosis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens