Delayed hypersensitivity and febrile acne conglobata.
Delayed hypersensitivity reactions were investigated in 5 patients with febrile acne conglobata. Each of them had febrile periods, large abscesses and leukocytosis. They reacted negatively to tuberculin 10 TU/ml, to Schick toxin, to oidiomycin, to trichophytin as well as to 25 common contact allergens. DNCB did not induce sensitization in those 4 patients in whom it was carried out. However, the transforamtion of lymphocytes by phytohaemagglutinin (PHA) was normal. Five of 7 control patients with cystic or ordinary acne had positive tuberculin test reactions and 3 of them were sensitized to DNCB.
D000152:Acne Vulgaris / Q000188:drug therapy / Q000276:immunology*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005334:Fever; D006801:Humans; D006968:Hypersensitivity, Delayed; D012882:Skin Tests
D000900:Anti-Bacterial Agents