In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.
Nine of 25 carefully selected compounds (from a stock of more than 200 000 chemical species amassed principally as a result of testing against other parasitic diseases) were found to have significant suppressive activity against the parasites in the blood of a Trypanosoma cruzi mouse model. Eight of these compounds evaluated in this model had suppressive activity equal to or greater than the reference compound, nifurtimox. For the first time, suppressive activity against T. cruzi is reported for a 7-aminoquinoline, a phosphonium salt, and TAC pamoate; The biological model is believed to be able to serve as a means of identifying other new "leads* in seeking drugs broadly effective against T=ruzi infections in man.
D013184:5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole / Q000494:pharmacology / Q000627:therapeutic use; D000634:Aminoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009547:Nifurtimox / Q000627:therapeutic use; D009861:Onium Compounds / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014320:Triphenylmethyl Compounds / Q000494:pharmacology / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects
D000634:Aminoquinolines; D009861:Onium Compounds; D014320:Triphenylmethyl Compounds; D014344:Trypanocidal Agents; C014872:tris(4-aminophenyl)carbonium pamoate; D013184:5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole; D009547:Nifurtimox