Effect of a diet of polyunsaturated fats on some platelet-function tests.
The fat in the normal diet of 19 apparently well men was partly replaced by linoleic acid. This produced striking changes in many platelet-function tests, suggesting decreased platelet activation. Twenty controls maintaining their normal diet showed no change. It is concluded that normal people have a degree of platelet activation which can be decreased. This may be relevant to the benefits attributed to a diet containing polyunsaturated fats.
D000328:Adult; D001772:Blood Cell Count; D001777:Blood Coagulation; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D004032:Diet; D004041:Dietary Fats; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010977:Platelet Factor 3 / Q000032:analysis; D010978:Platelet Factor 4 / Q000032:analysis
D004041:Dietary Fats; D008041:Linoleic Acids; D010977:Platelet Factor 3; D010978:Platelet Factor 4