Human beta-endorphin. Immunoreactivity of synthetic analogs with various chain lengths.
Immunoreactivity of synthetic human beta-endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that beta-endorphin-(1--21) and analogs of shortened chain exhibit no immunoreactivity, whereas beta-endorphin-(1--15) possesses significant in vitro opiate activity. It appears that immunoreactivity of beta-endorphin resides in the COOH-terminal segment of residues (22--31). The data also show the lack of correlation between opiate and immunological activities of beta-endorphin.
D000595:Amino Acid Sequence; D004723:Endorphins / Q000138:chemical synthesis / Q000276:immunology*; D000939:Epitopes; D007106:Immune Sera; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D011863:Radioimmunoassay; D013329:Structure-Activity Relationship
D004723:Endorphins; D000939:Epitopes; D007106:Immune Sera; D007457:Iodine Radioisotopes