Dapsone and severe hypoalbuminaemia. A report of two cases.
Severe hypoalbuminaemia developed in two patients on long-term dapsone treatment for dermatitis herpetiformis. The patients had been treated with dapsone for 3 and 11 years before the syndrome developed and both recovered completely when dapsone was withdrawn. Albumin-turnover studies revealed a great increase in intravascular albumin catabolism and a modest decrease in synthesis.
D000328:Adult; D001796:Blood Protein Disorders / Q000139:chemically induced* / Q000175:diagnosis; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects*; D003874:Dermatitis Herpetiformis / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis*; D012711:Serum Albumin, Radio-Iodinated; D012964:Sodium / Q000097:blood
D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D003622:Dapsone; D012964:Sodium