title: The ultrastructural changes of prostate adenocarcinoma following external beam radiation therapy.
abstract: Ultrastructural studies were done to determine the effects of radiation therapy on prostatic adenocarcinoma. Twenty patients were included in the study: 6 with benign hyperplasia, 4 with untreated adenocarcinoma and 10 with adenocarcinoma who had received radiation therapy. Benign and malignant ultrastructural characteristics were established. On the basis of these characteristics 6 of the 10 radiated prostates were believed to have tumor cells present after therapy. Of the remaining 4 patients 3 had ultrastructural changes suggesting radiation effects and a possibly altered malignant potential.
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D011467:Prostate / Q000648:ultrastructure; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000648:ultrastructure*; D011882:Radiotherapy, High-Energy