Target cell in chronic myeloid leukaemia and its relationship to acute lymphoid leukaemia.
On the basis of membrane marker analysis with an antiserum made against acute lymphoblastic leukaemia and other immunological markers it is suggested that some chronic myeloid leukaemias (C.M.L.) and some acute lymphoblastic leukaemias (A.L.L.) originate in a common target cell or precursor. This is possibly a pluripotential stem cell or a closely related derivative. These leukaemic cells retain their undifferentiated membrane characteristics C.M.L. patients in blast crisis who are A.L.L.-antigen-positive and have terminal transferase enzyme activity might benefit from therapy usually given in typical Philadelphia-chromosome-negative A.L.L.
D000951:Antigens, Neoplasm; D002462:Cell Membrane / Q000276:immunology; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm