title: [Sensitivity of microorganisms isolated from swine to aqueous and proteinic solutions of gentamycin].
abstract: Employing a microbiologic method (in vitro) the activity was investigated of Gentamicin DSO Pharmachim, dissolved in water, in normal swine gamma-globulin, and in normal swine polyglobulin with regard to swine strains of Escherichia coli, Salmonella choleraesis Bordetella bronchiseptica, and Pseudomonas aeruginosa as well as Mycoplasms. A strong sensitivity was found to exsist in all tested strains (except for the Mycoplasms) to gentamycin both in a water and in a protein solution. The in vivo testing of the therapeutic effect of the two types of solutions in an experimental infection in albino mice revealed that the differences found in the activity of the various gentamicin solutions were statistically insignificant. The step agglutination test was used to follow up the effect of gentamycin on the OK agglutinating antibodies of a gamma-globulin preparation against oedema disease in pigs. Results showed a slight increase in the agglutinating activity of the gamma-globulin antibodies under the effect of the antibiotic.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D004488:Edema Disease of Swine / Q000188:drug therapy; D004927:Escherichia coli Infections / Q000188:drug therapy; D005839:Gentamicins / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D051379:Mice; D008826:Microbial Sensitivity Tests; D012996:Solutions; D013552:Swine / Q000382:microbiology*; D005719:gamma-Globulins
chemical_list: D005839:Gentamicins; D012996:Solutions; D005719:gamma-Globulins
vernacular_title: Vurkhu chuvstvitelnostta na niakoi mikroorganizmi, izolirani ot svine, kum voden i beltuchni raztvori na gentamitsin.