title: Early idiopathic hemochromatosis with absent stainable bone marrow iron stores.
abstract: Early idiopathic hemochromatosis was diagnosed in a 52-year-old woman during the course of a hospitalization for another disorder. Quantitative studies revealed massive hepatic parenchymal siderosis and absent stainable marrow iron. Additionally, intestinal absorption and hepatic sequestration of radiolabeled iron were elevated. These studies in a patient with very early hemochromatosis, before organ damage, complement observations previously made in patients with advanced disease and provide further support for the concept that this disorder may result from impaired reticuloendothelial handling of iron.
mesh_terms: D001815:Bloodletting; D001853:Bone Marrow / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005293:Ferritins / Q000097:blood; D006680:HLA Antigens / Q000032:analysis; D006432:Hemochromatosis / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D007504:Iron Radioisotopes; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000378:metabolism; D013194:Staining and Labeling; D014018:Tissue Distribution
chemical_list: D006680:HLA Antigens; D007504:Iron Radioisotopes; D005293:Ferritins; D007501:Iron