Pharmacokinetic behaviour of bleomycin-cobalt-57 with special regard to intraarterial perfusion of the maxillo-facial region.
Bleomycin was traced by the isotope Cobalt-57. By using this radioactive substance the pharmacokinetic behaviour of the drug was examined. It was given either intravenously or intra-arterially or directly into the tumor in patients suffering from epidermoid carcinoma in the maxillo-facial region. The differences in the pharmacokinetic data are delineated. Practically, the intra-arterial route of administration is the best one because of the high adherence rate of the drug to the perfused tissue.
D001761:Bleomycin / Q000008:administration & dosage* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D010478:Chemotherapy, Cancer, Regional Perfusion; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D007269:Injections, Intra-Arterial; D007700:Kinetics; D011877:Radionuclide Imaging
D003037:Cobalt Radioisotopes; D001761:Bleomycin