title: Does the cancer accompanying acanthosis nigricans contain endocrine cells of the APUD series?
abstract: Following the publication of Hage & Hage, who believe that gastric cancers accompanying malignant acanthosis nigricans might constitute a specific group of carcinomas in which cells from parts of the tumor arise from the APUD-series of endocrine cells, carcinomas of 2 patients with malignant acanthosis nigricans were subjected to investigation. There were no APUD-cells in the adenocarcinomas studied but they were present in the overlying mucosa. It is known, moreover, that internal carcinomas not accompanying malignant acanthosis nigricans may contain APUD cells.
mesh_terms: D001078:APUD Cells / Q000473:pathology*; D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000150:complications / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology*