title: Hypotensive activity of some dihydroxycoumarins and their congeners.
abstract: Evaluation of the hypotensive activity of dihydroxy coumarins and their congeners reveal that the naturally occurring dimethoxy coumarin Scoparone has maximal activity, more significant than L-alpha-methyl dopa. Structure activity relationship studies are reported with an attempt to offer a probable mechanism of action.
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D001794:Blood Pressure / Q000187:drug effects; D001728:Dicumarol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D008750:Methyldopa / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000959:Antihypertensive Agents; D008750:Methyldopa; D001728:Dicumarol