[Mechanisms of the potentiating and blocking effects of the sera from tumor patients in the leukocyte migration inhibition reaction model].
In the model of the reaction of human blood leucocyte migration inhibition the in vitro study was conducted on some mechanisms of blocking and enhancement effects of the serum in 54 tumor patients. Both effects were shown to be specific to an antigen. The enhancement effect could render a nonspecific action on intact cells in the presence of the corresponding antigen. This effect is thermolabile and may occur due to the interaction with cells. The blocking effect is thermostabile and may be realizied through interaction with the antigen, cells or both simultaneously. Some possible mechanisms of the manifestation of the blocking and enhancement effects are discussed.
D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000276:immunology; D001859:Bone Neoplasms / Q000276:immunology*; D002464:Cell Migration Inhibition; D003165:Complement System Proteins / Q000276:immunology; D000939:Epitopes; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology*; D013696:Temperature
D000951:Antigens, Neoplasm; D000939:Epitopes; D007106:Immune Sera; D003165:Complement System Proteins
Mekhanizmy usilivaiushchego i blokiruiushchego éffektov syvorotok opukholevykh bol'nykh na modeli RTML.