title: Cyclic AMP and allergic histamine release. Influence of methylxanthines on rat mast cells.
abstract: Both isobutylmethylxanthine and theophylline increased the level of cyclic AMP in rat mast cells. Theophylline reduced the allergic histamine release, whereas isobutylmethylxanthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is inadequate.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology*
chemical_list: D014970:Xanthines; D013806:Theophylline; D000242:Cyclic AMP