[The appearance of immature cell leukemias after radiologic and cytostatic intensive therapy of Hodgkin's lymphoma].
Among 106 patients with Hodgkin's lymphoma in stage IIIB and IVB treated from September 1969 to June 1977 by a working team for hematology and oncology at the clinic and outpatients clinic of the Medical School of Erfurt, there were two cases (=1.9%) showing a final transition to leukaemia with immature cells. A third neoplasia which had developed in a former field of irradiation was additionally observed in one patient. The various possibilities arising from an oncologic effect of ionizing rays and those substances having a cytostatic effect are discussed. After frequent reports on the occurrence of secondary tumours following intensive radiological and cytostatic therapy of advanced Hodgkin's lymphoma the enhanced risk of a secondary tumour being induced by this combined therapy cannot be excluded. Various conclusions are drawn from that by the authors.
D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014748:Vinca Alkaloids / Q000627:therapeutic use
D014748:Vinca Alkaloids; D003520:Cyclophosphamide; D011239:Prednisolone
Zum Auftreten unreifzelliger Leukosen nach radiologischer und zytostatischer Intensivtherapie des Hodgkin-Lymphoms.