The transient loss of HLA antigens on lymphocytes in patients following administration of penicillin and tetracyclin.
Ten patients with inflammatory affections of urinary, respiratory and bile tract, as well as otitis patients were administered Penicillin. Six or seven days after the start of the treatment, four of them showed weakening or loss of minimally two earlier determined HLA antigens. The loss of HLA antigen was likewise demonstrated in a patient treated with Tetracycline. The HLA antigens were reliably demonstrated again six to seven days after the end of the treatment. The results suggest a possible false typing of HLA antigens in patients who had been administered Penicillin or Tetracycline. In accordance with Ben-David et al. [1] transient loss of two HLA antigens with concomitant development of lymphocyte polyreactivity was found in one of four patients treated with Chloramphenicol.
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002701:Chloramphenicol / Q000009:adverse effects; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D010406:Penicillins / Q000009:adverse effects; D013752:Tetracycline / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D006680:HLA Antigens; D010406:Penicillins; D002701:Chloramphenicol; D013752:Tetracycline