Comparison of tienilic acid with cyclopenthiazide in hyperuricaemic hypertensive patients.
Tienilic acid, a diuretic with uricosuric properties, was compared with cyclopenthiazide, in an open, random-order, within-patient crossover study (3 months on each drug) in 36 hyperuricaemic hypertensive patients. All were on an established dose of cyclopenthiazide; most were also on a beta-blocker which they continued to take in their usual dose. A mean dose of 210 mg of tienilic acid gave the same antihypertensive and diuretic effect as a mean dose of 0.41 mg of cyclopenthiazide. Serum uric acid was very much lower when patients were on tienilic acid (0.29 mmol/l) than on cyclopenthiazide (0.50 mmol/l). Apart from slightly higher serum-chloride and serum-urea during the period on tienilic acid, no major differences in serum-electrolytes, renal-function tests, glucose tolerance, and fasting lipids were observed. Audiometric tests showed that tienilic acid was not ototoxic. S.G.O.T. and S.G.P.T. rose to pathological values in 3 women when they were on tienilic acid, to a lesser extent, in 2 men when they were on cyclopenthiazide. There is no definite evidence that the changes in the transaminases were related to tienilic acid. Some postural hypotension or slight fluid retention occurred during the initial, dose-finding period, and 3 patients had mild indigestion but no patient had to discontinue the trial because of side-effects.
D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002986:Clinical Trials as Topic; D003518:Cyclopenthiazide / Q000008:administration & dosage*; D004232:Diuretics; D004341:Drug Evaluation; D004573:Electrolytes / Q000097:blood; D005951:Glucose Tolerance Test; D006016:Glycolates / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D010642:Phenoxyacetates / Q000008:administration & dosage*; D011674:Pulse / Q000187:drug effects; D011897:Random Allocation; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*; D014527:Uric Acid / Q000097:blood*
D004232:Diuretics; D004573:Electrolytes; D006016:Glycolates; D010642:Phenoxyacetates; D049993:Sodium Chloride Symporter Inhibitors; D013876:Thiophenes; D014527:Uric Acid; D003518:Cyclopenthiazide