Infantile vaginal tumour with alpha-fetoprotein synghesis.
A 17-month-old girl with a vaginal embryonal carcinoma (germ cell tumour) is reported. Alpha-fetoprtoein (AFP) was elevated before treatment in blood and vaginal fluid. Normal levels of AFP in blood and vaginal fluid were found after radiation and comination chemotherapy. By an indirect immunoperoxidase staining AFP was demonstrated in tumour tissue. 24-month-old local recurrence was preceded by a slight increase in serum AFP, and AFP could also be demonstrated in vaginal fluid and vaginal smears.
D005260:Female; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism*; D014621:Vagina / Q000378:metabolism; D014625:Vaginal Neoplasms / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000032:analysis / Q000096:biosynthesis*
D000509:alpha-Fetoproteins