title: Binding studies with antibodies having phosphorylcholine specificity and fragments derived from their homologous Streptococcus pneumoniae type 27 capsular polysaccharide.
abstract: The capsular polysaccharide from Streptococcus pneumoniae type 27 (S-27) has been fragmented into oligosaccharides by controlled degradations. Binding of these derived small ligands with heterogeneous rabbit anti-S-27 antibody of selected phosphorylcholine affinity indicates that a major immunodeterminant of S-27 is the phosphorylcholine moiety, but that these anti-PC. antibodies are also capable of binding to the polysaccharide backbone from which the P.C. has been removed.
mesh_terms: D000818:Animals; D001666:Binding Sites, Antibody; D002794:Choline / Q000031:analogs & derivatives*; D000939:Epitopes; D009844:Oligosaccharides / Q000276:immunology; D010767:Phosphorylcholine / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000939:Epitopes; D009844:Oligosaccharides; D011135:Polysaccharides, Bacterial; D010767:Phosphorylcholine; D002794:Choline