Acid hydrolases in monocytes from patients with inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis.
A sensitive technique was used to estimate two acid hydrolases--N-acetyl-beta-glucosaminidase (N.A.G.) and beta-glucuronidase (B.G.)--produced by peripheral-blood monocytes. Enzyme levels were measured after in-vitro incubation of monocytes with or without stimulation by zymosan and endotoxin. Compared with controls, enzyme production and release in inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis were markedly raised. It is suggested that various stimuli, including immunological ones, may be responsible for the release of such enzymes from monocytes and that such release may be a factor in the production of the chronic inflammation seen in these disorders.
D000118:Acetylglucosaminidase / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000201:enzymology; D003424:Crohn Disease / Q000201:enzymology; D004731:Endotoxins / Q000494:pharmacology; D005966:Glucuronidase / Q000097:blood*; D006505:Hepatitis / Q000201:enzymology; D006519:Hepatitis, Alcoholic / Q000201:enzymology; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000201:enzymology; D007410:Intestinal Diseases / Q000201:enzymology*; D008104:Liver Cirrhosis, Alcoholic / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology*; D008180:Lupus Erythematosus, Systemic / Q000201:enzymology; D009000:Monocytes / Q000201:enzymology*; D012485:Salmonella typhi; D013268:Stimulation, Chemical; D015054:Zymosan / Q000494:pharmacology
D004731:Endotoxins; D015054:Zymosan; D006596:Hexosaminidases; D005966:Glucuronidase; D000118:Acetylglucosaminidase