Susceptibility to experimental allergic encephalomyelitis in two strains of rats and their hybrids.
Lewis and PVG strains of rats and their F1-hybrids were challenged with guinea-pig or bovine encephalitogenic protein (EP) in Freund's complete adjuvant (FCA) to produce experimental allergic encephalomyelitis (EAE). The Lewis and F1-rats were also challenged with guinea-pig EP in FCA with a fivefold lower concentration of Mycobacterium butyricum. Data are presented concerning clinical signs and histological changes of EAE showing an intermediate position of susceptibility to EAE for the F1-hybrids compared to the parental strains. The findings are discussed in relation to the mode of inheritance of susceptibility to EAE. Among rats immunized with bovine encephalitogenic protein in FCA a weak activity was registered; this was difficult to evaluate, as it could be an effect of FCA only.
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics*; D005260:Female; D006824:Hybridization, Genetic; D008297:Male; D009161:Mycobacterium; D004676:Myelin Basic Protein; D051381:Rats; D011919:Rats, Inbred Strains
D004676:Myelin Basic Protein