Radiation-released histamine in the rhesus monkey as modified by mast-cell depletion and antihistamine.
4000 rads of mixed gamma neutron radiation administered to rhesus monkeys released a significant amount of histamine into their circulation. When the monkeys were treated with a mast-cell histamine depleter (compound 48/80) for 4 days and then irradiated, no increase in circulating histamine was seen. When 48/80 was give 20 min after irradiation, only a slight increase in histamine was seen, indicating that 4000 rads had released most of the mast-cell histamine.
D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology*; D005260:Female; D000882:Haplorhini; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects / Q000528:radiation effects*; D008253:Macaca mulatta; D008297:Male; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine; D003189:p-Methoxy-N-methylphenethylamine