The enhancing effect of multiple sclerosis brain homogenates on the active E rosette forming lymphocytes.
Lymphocytes from 15 of 17 patients with clinically well defined multiple sclerosis (MS) responded to all four MS brain homogenates as assayed by active E rosette test. Lymphocytes from only one neurological patient, out of 18 tested, responded to MS brain homogenates. The nature of the stimulating agent from MS brains remains to be determined.
D000328:Adult; D000368:Aged; D001921:Brain / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology; D012397:Rosette Formation