Proliferative response of H-2 incompatible leukocytes to an Abelson virus-induced lymphoma cell line apparently not expressing Ia-antigens.
The proliferative response of normal lymph node cells from different mouse strains to an Abelson virus-induced leukemic cell line (MLVA) in mixed leukocyte culture (MLC) has been investigated. MLVA leukemic cells do stimulate a specific response and the stimulating determinants are controlled, most likely, by genes in the K-end of the H--2 complex. However, using two different anti-Ia sera and different assay systems, we were unable to detect the expression of Ia-antigens on MLVA. In addition, an alloantiserum raised against MLVA, and absorbed with P815, a nonstimulating mastocytoma cell line, showed no residual activity against MLVA cells.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005796:Genes; D006183:H-2 Antigens; D007106:Immune Sera; D007519:Isoantigens; D007942:Leukemia, Experimental / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012190:Retroviridae
D000939:Epitopes; D006183:H-2 Antigens; D007106:Immune Sera; D007519:Isoantigens; D003165:Complement System Proteins