[Fibrinolytic properties of a heparin-ocrase complex].
The obtained heparin-ocrase complex includes properties of inhibiting coagulation and a high fibrinolytic activity in vitro and in vivo. The fibrinolytic activity of the heparin-ocrase complex is higher than the equivalent amount of ocrase. The fibrinolytic activity of the complex is not only evident on non-stabilized fibrin plates, but likewise on stabilized ones and at the presence of inhibitors of enzymatic fibrinolysis, such as Trasylol and epsilon-aminocaproic acid. The complex formation between heparin and protease was confirmed by means of cross-paper electrophoresis and spectrophotometry.
D000925:Anticoagulants; D001230:Aspergillus / Q000201:enzymology; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D010447:Peptide Hydrolases / Q000494:pharmacology*
D000925:Anticoagulants; D005340:Fibrinogen; D006493:Heparin; D010447:Peptide Hydrolases
Uber fibrinolytische Eigenschaften eines Heparin-Ocrase-Komplexes