A hapten-specific Ir gene.
When mice of different strains were immunized with a conjugate of 2-phenyloxazolone (phOx) and chicken serum albumin (CSA), the antibody response was controlled by an Ir gene (Ir-phOx). H-2 alleles d and f were associated with a high response, k and a with an intermediate response, and allele b with a low response. The effect of the Ir gene was clear-cut in anti-carrier antibodies of the primary and the secondary response when the concentrations of anti-carrier antibodies varied between 1 and 350 microgram/ml. Anti-hapten antibodies reached a ceiling of ca. 1000 microgram/ml that was unaffected by the Ir gene. Before the ceiling was reached, antihapten antibodies were also subject to the control of the Ir-phOx gene. When the same carrier CSA was coupled with other haptens, BOC-ABA-Tyr or NO2phOx, antibody responses were not under the control of the Ir-phOx gene. This gene is probably responsible for the differences that have been observed earlier in delayed hypersensitivity and antibody responses to skin painting by phOx.
D000818:Animals; D000917:Antibody Formation; D002645:Chickens; D002874:Chromosome Mapping; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006241:Haptens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010081:Oxazolone / Q000031:analogs & derivatives / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology
D000939:Epitopes; D006183:H-2 Antigens; D006241:Haptens; D012709:Serum Albumin; C018361:2-phenyloxazolone; D010081:Oxazolone