In vitro release of eosinophil chemotactic factor of anaphylaxis (ECF-A) from guinea pig skin.
An in vitro release of the eosinophil chemotactic factor of anaphylaxis (ECF-A) in anaphylactic reactions was studied using skin slices from actively sensitized guinea pigs. ECF-A and histamine were released in vitro from actively sensitized guinea pig skin by antigen challenge. The magnitude of ECF-A release did not always parallel that of anaphylactic histamine release in guinea pig skin, suggesting that there may be no correlation between the amount of ECF-A and that of histamine released from the skin in anaphylactic reactions in guinea pigs.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D002630:Chemotactic Factors / Q000378:metabolism*; D002631:Chemotactic Factors, Eosinophil / Q000378:metabolism*; D003165:Complement System Proteins; D006168:Guinea Pigs; D006636:Histamine Release; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008970:Molecular Weight; D012867:Skin / Q000276:immunology*
D002630:Chemotactic Factors; D002631:Chemotactic Factors, Eosinophil; D003165:Complement System Proteins