[Enzymatic N-acetylation of tryptamine by brain homogenates of Locusta migratoria before and after intoxication by chlordimeform or lindane (author's transl)].
Brain homogenates of Locusta migratoria are found to possess enzyme capable of catalyzing the N-acetylation of tryptamine. A main product of the enzymatic reaction is isolated and identified as N-acetyltryptamine by chromatography analyse. Both insecticides, chlordimeform and lindane, inhibit enzyme activity. A direct correlation between the degree of intoxication and acetylation of tryptamine is described.
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002742:Chlorphenamidine / Q000494:pharmacology*; D006110:Grasshoppers / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007700:Kinetics; D014363:Tryptamines / Q000378:metabolism*
D000578:Amidines; D014363:Tryptamines; D001556:Hexachlorocyclohexane; D000123:Acetyltransferases; D002742:Chlorphenamidine
N-Acétylation enzymatique de la tryptamine par des homogénats de cerveaux de Locusta migratoria avant et après intoxication par le chlordimeform ou le lindane.