title: Prostaglandins and breast cancer.
abstract: Malignant human breast tumours produced more prostaglandin-like material during homogenisation than did benign tumours or normal breast tissue. Greatest synthesis in vitro occurred with tumours associated with bone metastases, and the highest "basal" amounts tended to occur in tumours showing spread histologically. It is suggested that prostaglandins may play a part in tumour spread and growth in bone and that drugs which inhibit prostaglandin synthesis may be valuable therapeutic agents in cancer.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011458:Prostaglandins E / Q000032:analysis / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D001241:Aspirin