Cytochrome b is present in neutrophils from patients with chronic granulomatous disease.
Analysis of dithionite difference spectra demonstrated that cytochrome b was present in neutrophil homogenates from a 17-year-old girl and her 25-year-old brother who had the autosomal recessive form of chronic granulomatous disease, and from an 18-year-old boy with the X-linked form of chronic granulomatous disease. These results indicate that the postulated importance of cytochrome b in the oxygen burst during phagocytosis is questionable.
D000293:Adolescent; D000328:Adult; D003580:Cytochromes / Q000097:blood*; D004227:Dithionite; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000097:blood* / Q000235:genetics; D006801:Humans; D009504:Neutrophils / Q000201:enzymology*; D010375:Pedigree; D013053:Spectrophotometry / Q000379:methods
D003580:Cytochromes; D004227:Dithionite