Reduction of serum-1, 25-dihydroxyvitamin-D3 in children receiving glucocorticoids.
Serum-1,25-dihydroxyvitamin-D3 (1,25-[OH]2D3) was subnormal in children receiving long-term glucocorticoid treatment for various glomerular diseases, including nephrotic syndrome. In children with chronic glomerulonephritis not treated with glucocorticoids who had similar serum-creatinine with glucocorticoids who had similar serum-creatinine concentrations, serum-1,25-dihydroxyvitamin-D3 concentrations resembled those in healthy controls, indicating that glomerular renal disease per se does not account for reduced serum-1,25(OH)2DE concentrations in steroid-treated patients. The reduction in concentration of this most active vitamin-D metabolite correlated with the dose of steroid administered and with reduction in forearm bone mineral content measured by the photon absorption technique. Reduced serum-1,25-(OH)2D3 concentration may be important in the pathogenesis of steroid-induced osteopenia.
D000284:Administration, Oral; D000293:Adolescent; D001847:Bone Diseases / Q000139:chemically induced; D001842:Bone and Bones / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004100:Dihydroxycholecalciferols / Q000097:blood* / Q000378:metabolism; D005921:Glomerulonephritis / Q000188:drug therapy; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D014808:Vitamin D Deficiency / Q000139:chemically induced*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D011241:Prednisone