title: Effect of encephalitogenic protein on migration in agarose of leukocytes from patients with multiple sclerosis. A longitudinal study of patients with relapsing multiple sclerosis or with cerebral infarction.
abstract: Ten patients with MS were studied with leukocyte migration in agarose technique to detect changes in reactivity to encephalitogenic protein in connexion with a relapse. Six showed significant reactivity within a few days after the relapse. It decreased or disappeared during the 2 weeks after the relapse, but sometimes reappeared and was found in tests performed 2-3 months later. Five patients with cerebral infarction were studied in a similar way--in three, marked reactivity was noted within a few days after the stroke; in these, reactivity decreased or disappeared in later tests. In the two other patients, reactivity appeared in the second and/or third test. The possibility of a reactivity as in epiphenomenon due to CNS tissue destruction is discussed, and the need for antigens with a more restricted specificity for such an analysis is stressed.
mesh_terms: D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008137:Longitudinal Studies; D008214:Lymphocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000150:complications / Q000276:immunology*; D004676:Myelin Basic Protein / Q000494:pharmacology*; D012008:Recurrence; D012685:Sepharose
chemical_list: D004676:Myelin Basic Protein; D012685:Sepharose