title: Hb Lepore and (haemo-) blastomata.
abstract: The still increasing amount of carriers and anemics by thalassemia (Th) and other Hb-pathies (approximately 4,000 among approximately 48,000 investigated people) have shown that Campania is the most affected world area by all Hb Lepre conditions. Among 161 people with heterozygous Hb Lepore we have noticed 10 cases associated with (hemo-) blastomata as follows: 2 Chr. Lymphatic Leukemia, 2 Ac. Lymphoblastic Leukemia, 1 Lymphosarcom, 1 Colon Cancer, 1 Uterin Cancer, 1 Plasmocytom, 1 Hodkgin Disease, 1 Ac. Promyelocyte Leukemia (or fatal ac. agranulocytemia?). In the literature we recently found 2 other similar cases. The incidence of such malignancies in our Hb Lepore people reaches 6%. On the contrary in the heterozygous Th. group, among 3,150 carriers, we diagnosed only 20 people with (hemo-) blastomata as follows: 12 Ac. Leukemia (9Lymphoblastic) and 8 Chr. Myeloid Leukemia, with  an incidence rate of 0.6% namely a little higher than in normal people. This highly significant discrepancy rate shows an elective predisposition to (haemo-) blastomata from Leporian people.
mesh_terms: D003110:Colonic Neoplasms / Q000097:blood; D005260:Female; D005838:Genotype; D006453:Hemoglobinopathies / Q000276:immunology; D006455:Hemoglobins, Abnormal; D006579:Heterozygote; D006689:Hodgkin Disease / Q000097:blood; D006720:Homozygote; D007558:Italy; D007938:Leukemia / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood; D010954:Plasmacytoma / Q000097:blood; D013789:Thalassemia / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood
chemical_list: D006455:Hemoglobins, Abnormal