Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product.
F151 was a potent filaricide against adult Brugia pahangi in cats and jirds. HOE 33258 did not kill adult worms in cats but had a marginal effect on adult worms in the peritoneal cavity of jirds. It was not immediately microfilaricidal in cats but the microfilarial counts of treated cats fell within a few weeks of treatment. The reaction product, or mixture, of these two compounds (V5851 = E) was strongly macrofilaricidal in cats and jirds.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001152:Arsenicals / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D006690:Bisbenzimidazole / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001769:Blood / Q000469:parasitology; D002009:Brugia / Q000187:drug effects; D002415:Cats; D004338:Drug Combinations; D005368:Filariasis / Q000188:drug therapy* / Q000469:parasitology; D005369:Filaricides / Q000009:adverse effects / Q000627:therapeutic use*; D005849:Gerbillinae; D012883:Skin Ulcer / Q000139:chemically induced
D000871:Anthelmintics; D001152:Arsenicals; D001562:Benzimidazoles; D004338:Drug Combinations; D005369:Filaricides; C013747:F151; C013768:V5851; D006690:Bisbenzimidazole