Histone inhibition of mitochondrial proton transport.
Histone blocks proton uptake by mitochondria incubated in the presence of valinomycin or DNP. In the presence of DNP valinomycin-induced H+ uptake is not affected by histone. H+ uptake induced by nigericin is not affected by histone as well. Postulated mechanism of histone action involves the immobilization of proton translocation in mitochondrial membrane and induction of local change in H+ concentration, the prevention of the interaction between H+ and natural K+-carrier and Mg2+ transport system or valinomycin.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects*; D004140:Dinitrophenols / Q000494:pharmacology; D006657:Histones / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009550:Nigericin / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D014634:Valinomycin / Q000494:pharmacology
D004140:Dinitrophenols; D006657:Histones; D014634:Valinomycin; D008274:Magnesium; D009550:Nigericin; D011188:Potassium