Matching for HLA antigens of A, B, and DR loci in renal transplantation by Eurotransplant.
79 patients and their respective cadaveric kidney donors were typed for HLA-A, HLA-B, and HLA-DR antigens using frozen stored spleen lymphocytes and fresh peripheral-blood lymphocytes. The kidney-graft survival-rate at 3 to 18 months was highest when donor and recipient shared one or two DR antigens and three or four A and B antigens. The graft-survival rate was significantly higher (87 +/- 6%) at 18 months in these patients than in less well matched patients (48 +/- 9%).
D000939:Epitopes; D005500:Follow-Up Studies; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D007390:International Agencies; D016030:Kidney Transplantation; D009426:Netherlands; D011379:Prognosis; D013997:Time Factors; D014015:Tissue Banks; D014184:Transplantation, Homologous
D000939:Epitopes; D006680:HLA Antigens