[Hydramnios and fetal malformations. Use of estimating the level of alpha-fetoprotein and of bilirubin in the amniotic fluid during the last trimester of pregnancy (author's transl)].
Alpha-fetoprotein (AFP) levels in amniotic fluid have been measured by electro-immunodiffusion methods in the last trimester of pregnancy. 122 samples have been taken by abdominal amniocentesis during 58 pregnancies without hydramnios and 51 pregnancies with hydramnios. The level of AFP was always less than 1.2 mcg/ml when the children were normal in the latter group. On the other hand levels were higher than 1.2 mcg/ml in 17 out of 19 abnormal children. These had 5 neural tube abnormalities, 1 hydrocephalus, 3 duodenal atresias, 1 oesophageal atresia, 1 hare lip, 1 omphalocoele and 5 different malformations. The two abnormal children who had levels of AFP within normal limits were hydrocephalic. The diagnostic value of measuring bilirubinaemia which was also measured in 22 cases has been demonstrated.
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000032:analysis*; D001663:Bilirubin / Q000032:analysis*; D000013:Congenital Abnormalities / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D006831:Polyhydramnios / Q000209:etiology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D001663:Bilirubin
Hydramnios et malformations foetales. Intérêt du dosage de l'alpha-foetoprotéine et de la bilirubine amniotique au cours du dernier trimestre de la grossesse.