[Indices of lipid metabolism, thyroid gland and adrenal cortical function in prolonged stress of the central nervous system in chronic stimulation of the adrenals].
The experiments were conducted in 14 male rabbits dynamically on the 5th, 10th, 20th, 30th, 40th, 60th and 80th day of the central nervous system tension or at rest, including the studies of lipid metabolism (total cholesterol and beta-lipoproteins content), the function of the thyroid gland (protein bound iodine content) and the function of the adrenal cortex (11-OCS content). Such lasting stimulation of the adrenal cortex was found to be accompanied by hypercholesterolemia, hyper-beta-lipoproteinemia, elevated 11-OCS level and lack of thyroid function changes. A lasting tension of the central nervous system against the background of chronic stimulation of the adrenals delays the development of hypercholesterolemia and hyper-beta-lipoproteinemia, reduces the function of the thyroid gland, and increases the function of the adrenal cortex. The observed shifts in the lipid metabolism may be of atherogenic importance. The obtained data may be useful for the study of the pathogenesis of hormonal shifts in atherosclerosis.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000302:Adrenal Cortex / Q000503:physiopathology*; D000311:Adrenal Glands / Q000503:physiopathology*; D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D002784:Cholesterol / Q000378:metabolism; D002908:Chronic Disease; D003214:Conditioning, Classical / Q000502:physiology; D008026:Ligation; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology*; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol
Pokazateli lipidnogo obmena, funktsii shchitovidnoĭ zhelezy i kory nadpochechnikov pri dlitel'nom napriazhenii tsentral'noĭ nervnoĭ sistemy v usloviiakh khronicheskoĭ stimuliatsii nadpochechnikov