Evidence that L-rhamnose is the antigenic determinant of hyporesponsiveness of BALB/c mice to Klebsiella pneumoniae type 47.
The genetic polymorphism in early, immunoglobulin M, responsiveness to the Klebsiella pneumoniae type 47 polysaccharide (K47-PS) is determinant specific, and L-rhamnose is probably the determinant against which differential responsiveness is expressed. This is inferred from tests of the response to the cross-reacting Streptococcus pneumoniae type 23 and non-cross-reacting pneumococcal polysaccharides of known chemical construction. B10.2/Sn new-line mice are high responders and BALB/c mice are low responders to K47-PS. Upon immunization with killed S. pneumoniae type 23, these strains produce cross-reacting antibody to K47-PS. The cross-reacting antibody responses of these strains are congruent with their responses to K47-PS.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial; D003429:Cross Reactions; D000939:Epitopes; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012210:Rhamnose / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes; D011135:Polysaccharides, Bacterial; D012210:Rhamnose