Deficits in reticuloendothelial humoral control mechanisms in patients after trauma.
Plasma opsonic activity as expressed by an alpha-2-globulin which stimulates hepatic Kupffer cell phagocytosis, and thus modulates RES clearance, was determined in patients at varying intervals following whole-body trauma. Plasma opsonic activity decreased markedly following trauma in both nonsurviving (NS) and surviving (S) trauma patients as compared to an age- and sex-matched group of healthy volunteers. The initial post-traumatic hypoopsonemia (0-72 hr) was more severe (p less than 0.01) in nonsurviving patients than surviving patients. Survivors following trauma manifested restoration of opsonin levels with a definite transient rebound hyperopsonemia during the recovery phase (11-30 days); nonsurviving patients exhibited persistent systemic alpha-2-globulin opsonic deficiency. On the basis of previous animal and human studies, the presently observed humoral deficits following trauma in patients could contribute to impairment of reticuloendothelial Kupffer cell clearance of blood-borne particulate matter such as fibrin, damaged platelets, and other altered autologous tissue. The importance of post-trauma RES dysfunction to survival following severe injury warrants further investigation and clinical consideration.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000510:Alpha-Globulins / Q000032:analysis; D005260:Female; D006801:Humans; D007728:Kupffer Cells / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D009895:Opsonin Proteins / Q000032:analysis*; D010587:Phagocytosis; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology; D018805:Sepsis / Q000209:etiology / Q000276:immunology; D014947:Wounds and Injuries / Q000150:complications / Q000276:immunology*
D000510:Alpha-Globulins; D009895:Opsonin Proteins