title: Anatomical and functional aspects of the septo-hippocampal projections.
abstract: The origins, distribution, and cellular targets of the septo-hippocampal projections are reviewed. It appears that the distribution of acetylcholinesterase-positive neurons in the medial septum and diagonal bands and those cells labelled after injections of horseradish peroxidase into the hippocampus coincide; however, the possibility of a non-acetylcholinesterase septal projection remains. Good agreement is found between the distribution of hippocampal acetylcholinesterase and the patterning of silver grains after injection of [3H]leucine into the medial septum. A major target of septal efferents to the hippocampus is the interneuron population; the possibility of septal mediation of intrahippocampal circuitry via this anatomical arrangement is discussed.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001307:Auditory Perception / Q000502:physiology; D001345:Autoradiography; D001370:Axonal Transport; D001931:Brain Mapping; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology; D009410:Nerve Degeneration; D009433:Neural Inhibition; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000201:enzymology; D051381:Rats; D012688:Septum Pellucidum / Q000033:anatomy & histology* / Q000502:physiology
chemical_list: D000110:Acetylcholinesterase