Cellular immunity to encephalitogenic protein in multiple sclerosis. Correlations with other laboratory characteristics at different disease courses.
A very suggestive, although non-significant, correlation was found between cellular immunity to encephalitogenic protein in multiple sclerosis and the genetic marker HLA-B7 in patients with no disease activity during at least the past 5 years and in those with a chronic progressive disease course during recent years, but not in patients studied longitudinally after a relapse. Only the latter group showed a significant correlation with parameters indicating intrathecal synthesis of immunoglobulin. No correlation was demonstrable with a parameter indicating intrathecal synthesis of measles antibodies.
D000914:Antibodies, Viral / Q000032:analysis; D001772:Blood Cell Count; D002464:Cell Migration Inhibition; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007145:Immunoglobulin kappa-Chains / Q000134:cerebrospinal fluid; D007146:Immunoglobulin lambda-Chains / Q000134:cerebrospinal fluid; D007962:Leukocytes / Q000276:immunology; D008459:Measles virus / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology*; D012709:Serum Albumin / Q000032:analysis
D000914:Antibodies, Viral; D006680:HLA Antigens; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D004676:Myelin Basic Protein; D012709:Serum Albumin