title: Drug-induced gastrointestinal bleeding. Report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.
abstract: Rates of drug-induced gastrointestinal bleeding were estimated from data on 16 646 consecutively monitored medical inpatients who had no known predisposing illness. Heparin, warfarin, ethacrynic acid, steroids, and aspirin-containing drugs were associated with gastrointestinal bleeding and were estimated to account for about two-thirds of such bleeds. Major gastrointestinal bleeding, defined as bleeding severe enough to require transfusion, occurred in only 57 patients (0.3%).
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D002707:Chlordiazepoxide / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004976:Ethacrynic Acid / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D005938:Glucocorticoids / Q000009:adverse effects*; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D009582:Nitrofurantoin / Q000009:adverse effects; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; D014859:Warfarin; D002707:Chlordiazepoxide; D006493:Heparin; D009582:Nitrofurantoin; D004976:Ethacrynic Acid; D001241:Aspirin