ND1, a new neutrophil granulocyte antigen.
The serum of 2 patients suffering from autoimmune neutrophil granulocytopenia contained autoantibodies that were directed against a new granulocyte-specific antigen. Genetic analysis showed that this new antigen was not correlated with the already known neutrophil antigens, NA1, NA2, NB1, NC1 or 9a. This was studied in a four-generation family. In the Dutch population the frequency of the antigen, tentatively called ND1, is 98.5% (n = 67), pointing to a gene frequency of 0.88.
D000941:Antigens; D000939:Epitopes; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D010375:Pedigree
D000941:Antigens; D000939:Epitopes; D007106:Immune Sera