Circulating lymphocytes and the spread of myeloma. Review of the evidence.
Patients with myeloma harbour circulating lymphocytes which bear the idiotypic determinants (SIg-id+ cells) of their own myeloma protein. Circulating white cells with abnormal karyotypes have been found in other patients with this disease. SIg-id+ lymphocytes have also been identified in the peripheral blood of myeloma-tumour-bearing mice. Murine myelomas have been propagated in vivo from circulating mononuclear cells that possessed myeloma-tumour-associated antigens. This and other evidence reviewed here points strongly to the involvement of circulating lymphocyte-like stem cells in the spread of human myeloma.
D000818:Animals; D000951:Antigens, Neoplasm; D001775:Blood Circulation; D001798:Blood Proteins / Q000276:immunology; D000939:Epitopes; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology / Q000473:pathology*; D009194:Myeloma Proteins / Q000276:immunology; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology; D009360:Neoplastic Cells, Circulating
D000951:Antigens, Neoplasm; D001798:Blood Proteins; D000939:Epitopes; D009194:Myeloma Proteins