Convulsive effects of 3-aminopyridine on cortical neurones.
The authors examined the effects of 3-aminopyridine (3-AP) on pyramidal tract neurones in the motor cortex of anesthetised cats. 3-AP proved to be a strong convulsive agent. Local application of 3-AP in concentrations of 15-20 mM resulted in typical paroxysmal alterations of neuronal activity: (a) enhancement of background firing, (b) augmentation of EPSPs, (c) depression of IPSPs and (d) single and serial paroxysmal depolarization shifts (PDSs). Serial PDSs were reflected by large synchronous waves in the surface ECoG.
D000287:Administration, Topical; D000631:Aminopyridines / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004569:Electroencephalography; D005071:Evoked Potentials; D007275:Injections, Intravenous; D008564:Membrane Potentials / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects* / Q000503:physiopathology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
D000631:Aminopyridines