Cellular origin of interferon induced by bacterial lipopolysaccharide.
Bacterial lipopolysaccharide (LPS) induces interferons with different properties in mouse macrophages and B lymphocytes. Macrophage interferon is labile at 56 degrees C and is neutralized by anti-mouse fibroblast interferon at a dilution of 1:6,142. B cell interferon is more heat stable and is neutralized by the same antiserum only at a dilution of 1:276. Serum obtained early (1 h) after an intravenous injection of 100 mug of LPS resembled macrophage interferon, whereas serum obtained at later times resembled more and more B cell interferon. The diverse cellular origin of LPS-induced interferon may explain the broad hyporesponsiveness produced by LPS in animals.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D000961:Antilymphocyte Serum; D000939:Epitopes; D007369:Interferon Inducers; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D007372:Interferons