title: Priming potency of the products of individual regions of the H-2 complex and their role in the restimulation in secondary MLC.
abstract: Genetic analysis of the determinants causing an early proliferation in MLC after priming with allogeneic cells in vivo was performed. The active determinants were localized in the I-A subregion of the H-2 complex by using appropriate recombinant mouse strains. Upon priming with antigens coded by the whole H-2 complex, the lymphocytes gave a strong MLC response only to the priming stimulator cells and cells sharing the I-A subregion determinants of the latter. The response to third party stimulator cells and cells not sharing I-A subregion determinants was low. Upon priming with various H-2 region products, only lymphocytes primed against I-A subregion products gave an early proliferative MLC response to the priming stimulator cells, whereas lymphocytes primed against other H-2 region products gave none.
mesh_terms: D000818:Animals; D000939:Epitopes; D005796:Genes; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000939:Epitopes; D006183:H-2 Antigens