Bleomycin-methotrexate-chemotherapy in combination with telecobalt-radiation for patients suffering from advanced oral carcinoma.
20 patients suffering from advanced oral carcinoma (T3NXMO) were treated simultaneously with the cytostatics Bleomycin and Methotrexate and Telecobalt-radiation. 14 of them (70%) showed complete remission. Four relapses were treated by surgery. These patients are still alive and tumour-free. One patient with a tumour is also still alive. Five died of their tumours or other causes. As a preliminary result, overall survival of about 80% after the first year seems to be much higher than with other therapeutic procedures.
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000627:therapeutic use*; D002277:Carcinoma / Q000175:diagnosis / Q000628:therapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000628:therapy*; D011379:Prognosis; D011867:Radioisotope Teletherapy
D003037:Cobalt Radioisotopes; D001761:Bleomycin; D008727:Methotrexate