Management of postoperative constipation in anorectal surgery.
Fifty patients who had undergone proctologic operations were given a combination of standardized senna concentrate and dioctyl sodium sulfosuccinate for prevention or treatment of postoperative constipation. Two Senokot S tablets were given on the evening of the first postoperative day. Patients who had bowel movements after receiving this dose and remained in the hospital received two tablets on each of the following two days. Otherwise, dosage was increased gradually to a maximum of four tablets twice daily until defecation occurred or until the four-day treatment period was over. All patients achieved bowel movements, and in no case was it necessary to administer an enema. No hard stools were passed on the day patients were discharged from the hospital. Overall results were excellent or good in 94 per cent of cases; these results were not affected by age. Ninety-two per cent had bowel movements after the first or second dose was administered. On the day of discharge from the hospital, fecal consistency was satisfactory in 88 per cent of cases and loose in 12 per cent. Except for a single instance of diarrhea after administration of one dose, which involved a patient with a history of loose stools, no side effect occurred during the trial. In view of these responses and the virtual absence of side effects in this study group, Senokot S tablets are judged to be of demonstrated value in the postoperative management of patients undergoing proctologic operations.
D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery*; D002400:Cathartics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy*; D004143:Dioctyl Sulfosuccinic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010528:Peristalsis / Q000187:drug effects; D011183:Postoperative Complications / Q000188:drug therapy*; D012007:Rectum / Q000601:surgery*; D012676:Senna Extract / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013386:Succinates / Q000627:therapeutic use*
D002400:Cathartics; D006027:Glycosides; D013386:Succinates; D004143:Dioctyl Sulfosuccinic Acid; D012676:Senna Extract