title: [Improvement in the primary immunization scheme for children against whooping cough, diphtheria and tetanus].
abstract: The authors studied the reactigenic properties, immunological and epidemiological efficacy of vaccination of children aged under one year by the experimental schemes (AKDC-AKDC-K -- 1 ml, and AKDC-AKDC-K -- 0.5 ml) in comparison with the official pertussis, diphtheria, and tetanus immunization scheme. There proved to be a greater immunogenicity and a better protective effect against pertussis in vaccination according to the experimental schemes. The vaccine reactions were somewhat more incident in children vaccinated according to the AKDC-AKDC-K -- 1 ml scheme, but their essential reduction was reached with reduction of the pertussis antigen third vaccination dose to 0.5 ml.
mesh_terms: D000327:Adsorption; D000942:Antigens, Bacterial / Q000276:immunology; D002648:Child; D004165:Diphtheria / Q000517:prevention & control*; D004168:Diphtheria Toxoid / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007115:Immunization Schedule; D008213:Lymphocyte Activation / Q000187:drug effects; D010567:Pertussis Vaccine / Q000008:administration & dosage; D013742:Tetanus / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects; D014917:Whooping Cough / Q000517:prevention & control*; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D000942:Antigens, Bacterial; D004168:Diphtheria Toxoid; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid; D005719:gamma-Globulins
vernacular_title: Sovershenstvovanie skhemy pervichnoĭ immunizatsii deteĭ protiv kokliusha, difterii i stolbniaka.