Pool-priming: A means of generating T lymphocytes cytotoxin to tumour or virus-infected cells.
It is proposed that cells cytotoxic for autologous or syngeneic tumour cells can be produced in vitro by sensitisation of lymphocytes to a pool of normal cells from 20 unrelated individuals. Restriction on molecules that can serve as cytotoxic determinants (C.D.), may explain why a random pool of cells from 20 people could present essentially all of the determinants (C.D.) may explain why a random pool of occur because of extensive cross-reactivity of antigens on tumour cells with normal alloantigens present in the stimulating pool.
D000951:Antigens, Neoplasm; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006680:HLA Antigens; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D000951:Antigens, Neoplasm; D000939:Epitopes; D006680:HLA Antigens