Antenatal diagnosis of Duchenne muscular dystrophy.
As a means of assessing the value of fetal serum-creatine-kinase (S.C.K.) levels in the antenatal diagnosis of Duchenne muscular dystrophy (D.M.D.), fetal muscle from control and at-risk fetuses was studied histologically and the findings were related to fetal S.C.K. levels. Of 7 at-risk fetuses 4 were believed to have normal muscle and all these had normal S.C.K. levels. However, of 3 fetuses with abnormal muscle only 1 had a raised S.C.K. level. At present caution should be exercised in offering antenatal diagnosis in D.M.D. on the basis of fetal S.C.K. levels.
D003402:Creatine Kinase / Q000097:blood; D004804:Eosinophils / Q000032:analysis; D005069:Evaluation Studies as Topic; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D005333:Fetus / Q000473:pathology; D006801:Humans; D006818:Hyalin / Q000032:analysis; D008297:Male; D009132:Muscles / Q000473:pathology; D009136:Muscular Dystrophies / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis
D003402:Creatine Kinase