Plasma-secretin in management of cimetidine therapy for Zollinger-Ellison syndrome.
A patient with Zollinger-Ellison syndrome was treated by an H2-receptor blocking drug (cimetidine). Treatment was successfully monitored by plasma-secretin levels which were linearly related to the acid load delivered to the duodenum.
D000284:Administration, Oral; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D003864:Depression, Chemical; D004386:Duodenum / Q000378:metabolism; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D012633:Secretin / Q000097:blood*; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000188:drug therapy*
D006146:Guanidines; D012633:Secretin; D002927:Cimetidine