Effect of aging on immune and tolerant states.
A model has been described for studying the effect of aging on the cellular events involved in the induction, maintenance, and termination of a central tolerant state representative of the natural tolerant state to self. This model may permit an approach to the examination of the immune status of subpopulations of T and B cells to self antigens during aging. Prelminary data with NBZ mice, which show signs of accelerated autoimmune disease, suggest a possible defect detected by changes in polyclonal activation of B cells. This defect appears to be at the B cell level and not to involve suppressor T cells.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001324:Autoantigens; D001402:B-Lymphocytes / Q000276:immunology; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D008805:Mice, Inbred A; D008814:Mice, Inbred NZB; D013601:T-Lymphocytes / Q000276:immunology; D005719:gamma-Globulins / Q000276:immunology
D001324:Autoantigens; D005719:gamma-Globulins