Increased plasma binding of quinidine after surgery: a preliminary report.
The plasma binding of quinidine and phenytoin has been studied pre- and postoperatively in nine patients submitted to planned gastric surgery. The binding of phenytoin showed a slight and transient reduction, whilst quinidine binding was markedly increased, on average from 78.5% on the day of operation to a maximum of 87.5%, after 2-4 days. The time course of the increase was strikingly parallel to that of the concentration of certain acute phase proteins.
D000328:Adult; D000510:Alpha-Globulins / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism; D010672:Phenytoin / Q000097:blood; D011485:Protein Binding; D011802:Quinidine / Q000097:blood*; D012709:Serum Albumin / Q000378:metabolism; D013514:Surgical Procedures, Operative
D000510:Alpha-Globulins; D001798:Blood Proteins; D009961:Orosomucoid; D012709:Serum Albumin; D010672:Phenytoin; D011802:Quinidine