title: Splenectomy in myeloid metaplasia.
abstract: A retrospective review of 19 patients with documented myeloid metaplasia undergoing, elective splenectomy during the past ten years at the Peter Bent Brigham Hospital is presented. The primary indications for splenectomy in 17 of these 19 were either hypersplenism or symptomatic splenomegaly. Eighteen of the 19 underwent both 59Fe-ferrokinetic studies and 51Cr-sequestration studies or, alternatively, 111In-marrow scintigraphy as a part of their routine preoperative evaluation. The death from sepsis of one patient six weeks post-operatively, whose marrow function was poor and whose level of splenic sequestration was minimal, confirms the efficacy of these studies in the preoperative prediction of hematologic response to splenectomy. Eighteen of the 19 patients benefited from the operation in terms of symptomatic relief and/or hematologic improvement, although surgery presumably did nothing to prolong survival in these patients. We conclude that splenectomy is indicated as a palliative maneuver for carefully selected patients with myeloid metaplasia without prohibitive operative risk, provided the criteria for selection of patients are adhered to and the surgeon and hematologist work together as a team.
mesh_terms: D001900:Boston; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011183:Postoperative Complications; D011300:Preoperative Care; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology / Q000601:surgery