Suppression of experimental allergic neuritis with P2 protein of PNS myelin.
Experimental allergic neuritis was induced in the guinea pig with bovine PNS myelin. Treatment with P2 protein at the onset of the disease markedly reduced the severity of the clinical signs compared with untreated controls and animals treated with CNS myelin basic protein. The mortality was reduced from 94% in the combined control group to 50% in the treated group. Saline was a better vehicle for administration of the suppressive inoculation than incomplete Freund's adjuvant.
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D002417:Cattle; D006168:Guinea Pigs; D004676:Myelin Basic Protein / Q000627:therapeutic use; D009185:Myelin Proteins / Q000627:therapeutic use*; D009186:Myelin Sheath / Q000502:physiology*; D009443:Neuritis / Q000188:drug therapy* / Q000276:immunology; D010525:Peripheral Nerves
D004676:Myelin Basic Protein; D009185:Myelin Proteins