A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone.
The concomitant administration of pethidine (meperidine) and phenobarbitone results in enhanced sedation in a patient previously tolerant of pethidine. A complete analysis of pethidine kinetics and metabolism was performed in this patient, in four additional patients undergoing similar treatment but not receiving phenobarbitone, and in a volunteer after placebo and phentobarbitone pretreatment. The results indicate that phentobarbitone enhances the production of the toxic metabolite norpethidine by increasing N-demethylation.
D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006207:Half-Life; D006801:Humans; D008614:Meperidine / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity*; D009447:Neuroblastoma / Q000601:surgery; D010149:Postoperative Pain / Q000517:prevention & control; D010634:Phenobarbital / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery; D011300:Preoperative Care
D008614:Meperidine; D010634:Phenobarbital