Relationship between Fc receptors and Ia alloantigens: analysis with a sensitive radioimmunoassay.
This paper describes the successful use of 125I-labeled CgG aggregate to detect Ia-type alloantibodies in pregnancy sera. The blockade of aggregate uptake of a variety of normal mononuclear and leukemic cell types by anti-Ia alloantibodies is analyzed. Fc receptors and Ia alloantigens are clearly two distinct moleculr entities. The association between Fc receptors and Ia alloantigens on a quantitative level seems to depend on a ligand-binding mechanism to control their interaction rather than the presence of a topographical molecular tandem arrangement.
D001665:Binding Sites; D001667:Binding, Competitive; D002462:Cell Membrane; D000939:Epitopes; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens; D011247:Pregnancy; D011863:Radioimmunoassay
D000939:Epitopes; D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens