[Inhibition of DNAse I activity in vivo].
Immune gamma-globulins containing antibodies to bovine DNAse I inhibit activities of bovine and mouse DNAse I both in vitro and in vivo. Bovine DNAse I was used as exogenous DNAse I in the in vivo studies and was injected to mice intraperitoneally in combination with gamma-globulins. The serous fluid of mice was used as a source of endogenous DNAse I. Both in in vitro and in vivo studies immune gamma-globulins caused a practically complete inhibition of bovine DNAse I activity, whereas the activity of mouse DNAse I (endogenous) was inhibited by 60-80%. Nonimmune gamma-globulins had no inhibitory effects whatsoever.
D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors*; D051379:Mice; D013045:Species Specificity; D005719:gamma-Globulins
D005719:gamma-Globulins; D003851:Deoxyribonucleases
Ingibirovanie aktivnosti DNKazy I v opytakh in vivo.