Evidence for quasi-silent germline genes coding for phylogenetically ancient determinants of the rabbit a locus allotypes.
Anti-a2 sera raised in a3 rabbits are shown to detect determinants on a2 molecules which are different from those detected by anti-a2 sera raised in a1 animals. The former determinants are occasionally observed at a low level in rabbits of the a1 allotype and at a high level in sera of Leporidae of different genera. The two types of anti-a2 sera are shown to compete for the same sterical region of the a2 molecules. All homogeneous a2 molecules which have been tested show both types of determinants.
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D003429:Cross Reactions; D000939:Epitopes; D005796:Genes; D005779:Immunodiffusion; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G / Q000302:isolation & purification; D007518:Isoantibodies; D010802:Phylogeny; D011817:Rabbits; D011863:Radioimmunoassay; D013045:Species Specificity
D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007518:Isoantibodies