title: [The karyotype of bone marrow cells in the preleukemic phase of chronic myelocytic leukemia].
abstract: The caryotype of bone-marrow cells of 19 patients affected with leukocytosis of obscure origin was examined by means of G-staining. A chronic myelogenous leukaemia in its preleukaemic stage was diagnosed in 11 patients by identifying Ph'-chromosomes in all metaphases observed and a lowered acid leukocyte phosphatase. Besides Ph'-chromosomes an aneuploida (47 chromosomes with trisomia 8) was observed in one patient. The diagnostic and prognostic significance of this pathological caryotype is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000782:Aneuploidy; D001854:Bone Marrow Cells; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D007964:Leukocytosis / Q000188:drug therapy / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000097:blood*; D013163:Splenomegaly / Q000209:etiology
chemical_list: D000469:Alkaline Phosphatase
vernacular_title: Untersuchungen über den Karyotyp der Knochenmarkzellen in der präleukämischen Phase der chronischen myeloischen Leukämie.