[Biological properties of the modified actinomycins synthesized by the aurantin producer].
The effect of 2 new modified actinomycins was studied. Actinomycin AuGl had the residue of sarcozin replaced by glycine and actinomycin AuNv had 1 residue of norvaline. It was shown that the new actinomycins had a similar to the actinomycin type effect on the microbial and animal cells. Still, higher concentrations of the antibiotics were required. In concentrations equal to those of actinomycins the new antibiotics were less effective with respect to the bacteriostatic action, suppression of the RNA synthesis and mitotic division of the ascitic hepatoma 22A cells.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D004269:DNA, Bacterial / Q000494:pharmacology; D003609:Dactinomycin / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000188:drug therapy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008826:Microbial Sensitivity Tests; D008938:Mitosis / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013302:Streptomyces / Q000378:metabolism
D000596:Amino Acids; D004269:DNA, Bacterial; D005419:Flavonoids; D012334:RNA, Neoplasm; D003609:Dactinomycin
Biologicheskie svoĭstva modifitsirovannykh aktinomitsinov, sinteziruemykh produtsentom aurantina.