title: Study of substances related to carcinoembryonic antigens, CEA-NCA and association with alpha1-antichymotrypsin.
abstract: The alpha-protein which we previously detected in PCA extracts of malignant tumours, normal tissues, sera and other body fluids has been further tested. The alpha-protein was identified by immunological methods as alpha1-antichymotrypsin. Experiments by crossed immunoelectrophoresis showed that this protein cross-reacts with the betaE-protein found in the PCA extracts. The betaE-protein shows heterogeneity in molecular size, electrophoretic mobility and it has been demonstrated that it shares antigenic determinants with the CEA or betaI-molecule. Cross-reaction between betaE and other glycoproteins found in the PCA extract of normal or malignant tissue or serum was not detected.
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002850:Chromatography, Gel; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D003110:Colonic Neoplasms / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis; D009363:Neoplasm Proteins / Q000032:analysis*; D010472:Perchlorates / Q000494:pharmacology
chemical_list: D002272:Carcinoembryonic Antigen; D000939:Epitopes; D007106:Immune Sera; D009363:Neoplasm Proteins; D010472:Perchlorates; D002918:Chymotrypsin