title: [Alterations in pharmacokinetics during toxicity tests (author's transl)].
abstract: Some possible reasons are discussed which may lead to changes in the pharmacokinetics of a drug during long-term toxicity tests. Since most of these alterations have toxicological consequences, their evaluation can be helpful in the interpretation of toxicity studies. Furthermore, and altered pharmacokinetic profile may be a diagnostic tool for the detection of organ damage (e.g., eliminatory organs). In this paper three examples of the "radioactive test dose method" are shown. This method allows a direct comparison of the pharmacokinetics between pretreated animals and controls by administration of a single radioactive test dose to both groups.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001556:Hexachlorocyclohexane / Q000378:metabolism; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014116:Toxicology
chemical_list: D004364:Pharmaceutical Preparations; D001556:Hexachlorocyclohexane
vernacular_title: Pharmakokinetische Untersuchungen als Hilfsmittel zur Interpretation des Verlaufs von Toxizitätsprüfungen.