Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal. Autoreactivity in rabbits of antibodies to sperm-whale myoglobin.
Sequence comparisons between the antigenic sites of sperm-whale myoglobin and the corresponding regions in rabbit myoglobin indicate that rabbits make antibodies to regions of the sperm-whale myoglobin molecule which are identical to the corresponding regions in rabbit myoglobin. Rabbit myoglobin did not precipitate with antisera to sperm-whale myoglobin. However, it exhibited an extensive cross-reaction as demonstrated by its ability to inhibit the precipitin reaction of sperm-whale myoglobin, and on an immunoadsorbent, bound a large amount of antibodies to sperm-whale myoglobin.
D000595:Amino Acid Sequence; D000818:Animals; D000937:Antigen-Antibody Reactions; D001323:Autoantibodies; D000939:Epitopes; D006041:Goats / Q000276:immunology; D007163:Immunosorbent Techniques; D009211:Myoglobin / Q000276:immunology*; D011487:Protein Conformation; D011817:Rabbits / Q000276:immunology; D013045:Species Specificity; D014907:Whales / Q000276:immunology
D001323:Autoantibodies; D000939:Epitopes; D009211:Myoglobin