title: Severe malaria and glucose-6-phosphate-dehydrogenase deficiency: a reappraisal of the malaria/G-6-P.D. hypothesis.
abstract: Nigerian children with convulsions and Plasmodium falciparium parasitaemia above 100,000/microliter did not show a decreased frequency of glucose-6-phosphate-dehydrogenase (G.-6-P.D.) deficiency. A re-evaluation of earlier studies has led to the conclusion that clinical evidence of protection against falciparum malaria in G.-6-P.D.-deficient individuals is lacking. Evidence for the possible role of malaria in selecting for G.-6-P.D.-deficient genes consists solely of the geographical association of high frequencies of G.-6-P.D. deficiency with endemic malaria.
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D005958:Glucosephosphates; D006801:Humans; D008288:Malaria / Q000201:enzymology / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D009549:Nigeria; D010963:Plasmodium falciparum; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D012737:Sex Factors
chemical_list: D005958:Glucosephosphates; D005954:Glucosephosphate Dehydrogenase