title: Effects of the number of DNP groups on dinitrophenylated human serum albumin upon the induction of immunological memory for the dinitrophenyl determinant.
abstract: Immunological memory to the DNP determinant is shown to be a positive correlate of the primary anti-DNP response and of the extent of DNP substitution in the priming antigen. Antigen dose-response curves for immunological memory first increase with antigen dose to reach a maximum and then decrease in the high dose region. Increasing the extent of DNP substitution in the priming antigen shifts the dose-response curves to lower antigen doses and promotes the antigen's ability to induce immunological memory to a level greater than that expected by its ability to induce a primary response. The findings are interpreted in terms of postulated effects of degree of DNP substitution on the binding of antigen to cell receptors.
mesh_terms: D000917:Antibody Formation / Q000187:drug effects; D004136:Dinitrobenzenes / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D006801:Humans; D007156:Immunologic Memory; D009578:Nitrobenzenes / Q000276:immunology*; D012709:Serum Albumin / Q000276:immunology*
chemical_list: D004136:Dinitrobenzenes; D000939:Epitopes; D009578:Nitrobenzenes; D012709:Serum Albumin