The structure and evolution of the HLA--Bw4 and Bw6 antigens.
The HLA--Bw4 and Bw6 antigenic determinants have been shown to co-migrate with HLA--B determinants on gel-filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human beta 2 microbulin. These and other published data imply that the HLA--Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA--B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA--B locus are discussed.
D005075:Biological Evolution; D002462:Cell Membrane / Q000276:immunology; D002499:Centrifugation, Density Gradient; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D002874:Chromosome Mapping; D003429:Cross Reactions; D000939:Epitopes; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D001613:beta 2-Microglobulin / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens; D001613:beta 2-Microglobulin