title: Paradoxical sleep deprivation: effects on brain energy metabolism.
abstract: A study was made of brain nucleotides and glycolytic intermediates in paradoxical sleep (PS)-deprived and recovery-sleeping rats. It was observed that PS deprivation of 24 h produced a fall in glucose, glucose 6-phosphate and pyruvate in cerebral frontal lobes. After three hours of recovery sleep all values returned toward their predeprivational levels. In cerebellar hemispheres ATP was increased, while glucose 6-phosphate and pyruvate were decreased. After three hours of recovery sleep, glucose 6-phosphate was increased and pyruvate decreased, indicating restoration of glycogen and creatine phosphate respectively.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D012892:Sleep Deprivation; D012895:Sleep, REM
chemical_list: D005958:Glucosephosphates; D007773:Lactates; D011773:Pyruvates; D000255:Adenosine Triphosphate; D005947:Glucose