Inhibition of blastic transformation and immunoglobulin release in lymphocytes cultured in the presence of alpha-fetoprotein (AFP).
Blastic transformation of phytohemagglutinin-stimulated lymphocytes in cultures containing various concentrations of homogenous alpha-fetoprotein (AFP) was studied. It was found that AFP in concentrations of 4-12 microgram/ml inhibits both blastic transformation and immunoglobulin release (IgA, IgG) in lymphocyte cultures. It is suggested that AFP plays an important role in immunoregulation during the fetal life.
D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008940:Mitotic Index; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors*; D000509:alpha-Fetoproteins / Q000494:pharmacology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins; D010835:Phytohemagglutinins; D000509:alpha-Fetoproteins