Deposits of complement and immunoglobulins in dermal and synovial vessels in psoriasis.
Deposits of complement C3 and/or immunoglobulin were found in the vessel walls and/or at the dermal-epidermal junction in skin lesions of all of 11 patients with psoriatic arthritis and guttate psoriasis. Similar deposits were seen in 6 out of 15 patients with psoriasis vulgaris. Synovial tissue available from 2 patients revealed deposits in the vessel walls.
D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D011565:Psoriasis / Q000276:immunology*; D012867:Skin / Q000098:blood supply*; D013583:Synovial Membrane / Q000098:blood supply*
D003176:Complement C3; D007070:Immunoglobulin A; D007075:Immunoglobulin M