Pathophysiology of generalized penicillin epilepsy in the cat: the role of cortical and subcortical structures. I. Systemic application of penicillin.
The mechanism of precipitation of generalized epileptiform discharges in feline generalized penicillin epilepsy, a model of human generalized corticoreticular ('centrencephalic') epilepsy, was studied in acute and chronic experiments in cats with implanted skull and intracerebral electrodes. Single shock and low frequency repetitive stimulation of subcortical sites from which prior to penicillin administration spindle activity and recruiting responses could be elicited, readily triggered epileptiform discharges in the same animals after penicillin. These structures comprised the intralaminar and midline thalamic nuclei, the neostriatum, and some posterior thalamic association nuclei (Pulvinar and nucleus lateralis posterior). Subcortical and cortical structures which prior to penicillin elicited neither spindle activity nor recruiting responses were significantly less effective in  triggering generalized epileptic bursts after penicillin injection. The probability with which such bursts were elicited from these structures was still, however, in many instances above chance level. It is concluded that the generalized epileptiform discharges in feline generalized penicillin epilepsy can be triggered from a large number of brain sites, but most reliably so from subcortical nuclei involved in spindle generation and recruiting responses. The experimental evidence presented still does not allow one to determine whether epileptic alteration of neuronal function in this form of epilepsy primarily resides in cortical or subcortical nerve cells or in both.
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002415:Cats; D002540:Cerebral Cortex / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D006179:Gyrus Cinguli / Q000503:physiopathology; D007273:Injections, Intramuscular; D008297:Male; D010400:Penicillin G / Q000008:administration & dosage* / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced*; D013787:Thalamic Nuclei / Q000503:physiopathology
D010400:Penicillin G