Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen.
The antibody response to dextran B1355 is thymus independent, and in high responder mice, over 90% of the antibodies carry the idiotype of an alpha-1,3 binding myeloma protein (J558). The present experiments demonstrate: (a) dextran B1355 is a B-cell mitogen both in a strain which carries the J558 idiotype on antibodies and in a low-responder strain which does not express that idiotype on antibodies to dextran; (b) anti-idiotypic antibodies to J558 recognize a dextran-specific surface receptor on 10--15% of all splenic B cells in those two strains as well as in all strains so far tested; (c) as shown by inhibition experiments such surface receptors cross-react with J558, and (d) anti-idiotypic antibodies are mitogenic for spleen cells of both strains resulting in B-cell proliferation and maturation to polyclonal antibody secretion.
D000906:Antibodies; D001402:B-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D001665:Binding Sites; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D003911:Dextrans / Q000276:immunology*; D000939:Epitopes; D008934:Mitogens; D009194:Myeloma Proteins / Q000276:immunology
D000906:Antibodies; D003911:Dextrans; D000939:Epitopes; D008934:Mitogens; D009194:Myeloma Proteins