Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine. This study demonstrates the appearance of the MII-type isoenzyme in various gliomas. This MII type is also found in meningiomas but not in normal brain tissue. The method of enzyme examination described may be valuable as a diagnostic aid in the surgery of gliomas.
D000409:Alanine / Q000494:pharmacology; D001932:Brain Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D005910:Glioma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008579:Meningioma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D011770:Pyruvate Kinase / Q000037:antagonists & inhibitors*
D007527:Isoenzymes; D011770:Pyruvate Kinase; D000409:Alanine