title: Local effect of single stranded polyadenylic acid on passive cutaneous anaphylaxis in mice.
abstract: Single stranded polyadenylic acid (Poly A) administered locally inhibited passive cutaneous anaphylaxis in mice. In experiments performed by equilibrium dialysis Poly A was able to bind histamine. The association constant of the reaction was determined, Ka = 1.3 +/- 0.2 x 10(5) I/M. One Poly A molecule can bind maximally two molecules of histamine dichloride. Poly A inhibited the antigen-induced release of histamine from the peritoneal rat mast cells when it was given together with sensitizing antibodies.
mesh_terms: D000818:Animals; D006632:Histamine / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011061:Poly A / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
chemical_list: D011061:Poly A; D006632:Histamine