Modification of testicular steroid metabolism in the rat during gonadotrophin administration.
The administration of human chorionic gonadotrophins to adult rats stimulates the formation of testosterone, 7alpha-hydroxy-testosterone and 5alpha-androstanediol in incubated testes. When the gonadotrophins are injected for several days, the testosterone formation is maintained at a high level; however, the transformation to 7alpha-hydroxy-testosterone decreases progressively to subcontrol levels, while 5alpha-androstanediol is produced in greater amounts.
D015113:Androstane-3,17-diol / Q000096:biosynthesis*; D000731:Androstanes / Q000096:biosynthesis*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D006915:Hydroxytestosterones / Q000096:biosynthesis; D008297:Male; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D000731:Androstanes; D006063:Chorionic Gonadotropin; D006915:Hydroxytestosterones; D015113:Androstane-3,17-diol; D013739:Testosterone