[Effect of partial modification of serum albumin on its conformation and complex-forming activity].
In using a series of the succinic anhydride concentration the authors obtained preparations of succinylated albumin with a different degree of modification. The effect of succinylation on the immunochemical and some physico-chemical properties of albumin were investigated; depending on the concentration of the modifying reagent preparations of succinylated albumin proved to differ by the antigenic properties, electrophoretic mobility in agar gel and the complex-forming activity in interaction with rivanol. Conditions of partial modification permitting to increase the complex-forming properties of albumin 3-fold with the minimal changes in its structure were determined.
D055598:Chemical Phenomena; D002621:Chemistry; D004587:Electrophoresis, Agar Gel; D000939:Epitopes; D006801:Humans; D011487:Protein Conformation; D012709:Serum Albumin; D013386:Succinates
D000939:Epitopes; D012709:Serum Albumin; D013386:Succinates
Vliianie chastichnoĭ modifikatsii syvorotochnogo al'bumina na ego konformatsiiu i kompleksoobrazuiushchuiu aktivnost'