[Alpha fetoprotein and HbF cells in the maternal blood and their modification through amniocentesis].
In 101 patients of the Frauenklinik der Medizinischen Hochschule Hannover we have measured the concentrations of fetal cells and alpha-fetoprotein before and after amniocentesis. There was a significant increase in both parameters corresponding to an arbitrary fetomaternal haemorrhage of 0,05--0,4 ml. AFP seemed to be more reliable than the fetal cell count. The site of placentation was of no influence on the fetomaternal haemorrhage. As less than 0,1 ml rhesus-positive fetal blood is enough to cause isoimmunization in mothers at risk we highly recommend to give immunoglobulin-anti-D to all unsensitized rhesus-negative mothers after amniocentesis.
D000649:Amniocentesis; D004899:Erythroblastosis, Fetal / Q000097:blood; D004906:Erythrocyte Count; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D005331:Fetomaternal Transfusion / Q000097:blood; D006801:Humans; D011247:Pregnancy; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D005319:Fetal Hemoglobin
Alpha-Fetoprotein und HbF-Zellen im maternen Blut und ihre Beeinflussung durch Amniozentesen.