[Histamine-liberating action of MCD-peptide from bee venom].
Histamine release (HR) from the isolated rat mast cells induced by MCD-peptide, mellitin (from the Apis mellifica venom) and compound 48/80 was studied. The dose-response curve, the latent period and temperature dependence of HR induced by MCD-peptide were similar to those of HR induced by compound 48/80. The HR induced by MCD-peptide proved to be an energy-dependent process that was independent of cyclic adenosine-3',5'-monophosphate.
D000818:Animals; D001516:Bees; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008555:Melitten / Q000494:pharmacology; D010208:Papaverine / Q000037:antagonists & inhibitors; D010455:Peptides / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013696:Temperature; D014688:Venoms / Q000032:analysis*; D014970:Xanthines / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D010455:Peptides; D011458:Prostaglandins E; D014688:Venoms; D014970:Xanthines; D008555:Melitten; D003189:p-Methoxy-N-methylphenethylamine; D010208:Papaverine; D000242:Cyclic AMP
Osobennosti gistaminvysvobozhdaiushchego deĭstviia MCD-peptida iz iada pchel.