[DNA synthesis in rat liver following administration of antihepatocytotoxic serum].
Experiments were conducted on adult female rats. The autoradiographic method was applied to the study of thymidine-3H incorporation into the parenchymatous and reticulo-endothelial cells of the liver under conditions of using low doses (0.06 microgram of protein per 100 of body weight) of antihepatocytotoxic serum (AHCS), gamma-globulin isolated from it (gammaAHCS) and gamma-globulin fraction of normal rabbit serum (gammaNRS) to intact animals and rats with carbon tetrachloride affection of the liver. The labelled nuclei index of both the parenchyma and the reticuloendothelial cells increased in case of gammaAHCS administration, and, to a lesser extent, of AHCS to intact animals. gammaAHCS used against the background of CCl4 administration intensified the reparative regeneration. The action of gammaAHCS has phasic character--the period of the labeled nuclei elevation was followed by their reduction, replaced by new intensification of the proliferative processes.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology* / Q000628:therapy; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D007106:Immune Sera / Q000494:pharmacology*; D007116:Immunization, Passive; D008099:Liver / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D005719:gamma-Globulins / Q000627:therapeutic use
D007106:Immune Sera; D005719:gamma-Globulins; D004247:DNA
Sintez DNK v pecheni krys v usloviiakh primeneniia antigepatotsitotoksicheskoĭ syvorotki.