title: [Experimental infection of domestic animals with R. prowazeki and R. canada].
abstract: The authors infected lambs with R. prowazeki and R. canada to ascertain their possible role in the natural infection of the animals. The lambs were infected subcutaneously with increasing doses; rickettsiemia was recorded with the aid of tests on guinea pigs and Ixodidae and Argasidae ticks fed on the lambs. Dynamics of antibody formation was ascertained in the infected animals in the agglutination reaction and in the complement fixation test. The antigenic affinity of R. canada and rickettsia of the typhoid group and the presence of common antigenic determinants with the Proteus OX19 was confirmed. The absence of any clinical manifestations, the character of antibody formation, impossibility of inducing the generalized infection and of the isolation of the causative agent from the blood pointed to the low susceptibility of lambs to R. prowazeki and R. canada; thus a possibility of circulation of the causative agents of typhius among the domestic animals scarcely probable.
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D003168:Complement Fixation Tests; D003429:Cross Reactions; D000939:Epitopes; D011511:Proteus / Q000276:immunology; D012281:Rickettsia / Q000276:immunology / Q000472:pathogenicity*; D012282:Rickettsia Infections / Q000276:immunology / Q000662:veterinary*; D012283:Rickettsia prowazekii / Q000276:immunology / Q000472:pathogenicity; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology*; D014438:Typhus, Epidemic Louse-Borne / Q000276:immunology / Q000635:transmission / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D000939:Epitopes
vernacular_title: Eksperimental'noe zarazhenie domashnikh zhivotnykh R. prowazeki i R. canada