The treatment of hypertrophy of the prostate of rats with 4-nitro-3-trifluoromethylisobutyranilide (Sch 13521).
A study was carried out in 146 common rats to assess the effects of 4'-nitro-3'-trifluoromethylisobutyranilide (Sch 13521) on the hypertrophied prostate gland. The hypertrophy was induced in castrated, sexually immature males by s.c. implantation of a pill of testosterone-propionate. After 20 days of administration of Sch 13521 in oral doses of 5, 10 and 25 mg/kg, the dimensions and weight of the hypertrophied prostate gland were reduced by 1.5 to 2 times. After 2 months of administration of the preparation in doses of 10 and 25 mg/kg a reduction of the hypertrophied prostate gland to the dimensions of the intact control was observed. Morphological studies confirmed the efficacy of the therapeutic action of Sch 13521.
D000813:Anilides / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002369:Castration; D005485:Flutamide / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
D000813:Anilides; D013739:Testosterone; D005485:Flutamide