Histamine release reaction of basophils in chronic granulocytic leukaemia. Induction by heterologous anti-immunoglobulin E, concanavaline A, and phytohaemagglutinin; effect of heavy water.
Basophils possess membrane bound IgE molecules, and immunological activation leads to a secretory process with cell degranulation and histamine release. Heterologous anti IgE, concanavaline A, and phytohaemagglutinin are potent non-cytotoxic releasing agents. They operate by a mechanism similar to that of immunological activation. Heavy water is not a histamine releasing inducer but it increases histamine release of the cells. We studied the histamine release reaction of leukaemic basophils in 10 patients and found a physiological response such as that previously reported with normal human basophils.
D000888:Antibodies, Anti-Idiotypic; D001491:Basophils / Q000276:immunology / Q000502:physiology*; D003208:Concanavalin A / Q000494:pharmacology; D003903:Deuterium / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E; D007951:Leukemia, Myeloid / Q000276:immunology* / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology
D000888:Antibodies, Anti-Idiotypic; D010835:Phytohemagglutinins; D003208:Concanavalin A; D007073:Immunoglobulin E; D003903:Deuterium