The transient HLA antigenic loss dependent on hormonal state of organism in a healthy woman.
In a healthy 44-year-old female blood donor with HLA phenotype HLA-A 2, A 10/B 7, BW 15 repeatedly the transient loss of HLA antigens was proved during the menstrual period and supposed ovulation. Within the interval between menstruation and ovulation the antigens could reliably be proved. The results support the view that in women hormonal effects may influence the HLA antigenic expressivity. The significance of this observation for reliable typing of HLA antigens in women is discussed.
D000328:Adult; D000939:Epitopes; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing / Q000592:standards; D006801:Humans; D007165:Immunosuppression Therapy; D008598:Menstruation; D010060:Ovulation
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens