title: Effect of pregnancy zone protein on leucocyte migration inhibition, lymphoycte transformation and rosette formation by lymphocytes.
abstract: Pregnancy zone protein from pregnancy serum and control preparations from male serum were tested in lymphocyte transformation tests, in a system for rosette formation by T and B lymphocytes and in leucocyte migration inhibition tests using PPD-induced inhibition. PZ-protein preparations caused a dose dependent inhibition of lymphocyte transformation after stimulation with PHA, PPD and MLC. Inhibition was most pronounced in the PHA-system. In the rosette tests there was a tendency for T lymphocytes to bind fewer SRBC after incubation with PZ-protein while no effect on B rosettes was observed. In contrast, PPD-induced inhibition of leucocyte migration was abrogated effectively by PZ-protein, but not by corresponding fractions from male serum.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology; D014373:Tuberculin / Q000494:pharmacology; D000511:alpha-Macroglobulins / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents; D010835:Phytohemagglutinins; D014373:Tuberculin; D000511:alpha-Macroglobulins