Monoclonal characteristics of organising arterial thrombi: Significance in the origin and growth of human atherosclerotic plaques.
The clonal characteristics of 26 arterial thrombi at different stages of organisation were determined using the X-linked enzyme, glucose-6-phosphate dehydrogenase (G.-6-P.D.), as a clonal marker in 13 women heterozygous for electrophoretically separable G.-6-P.D. isoenzymes. A gradation of increasing monoclonality was observed with increasing organisation of the thrombi, such that only 21% of poorly organised (red) thrombi displayed monoclonal characteristics similar to those of atherosclerotic plaques, whereas 78% of moderately organised (pink) thrombi and 91% of well-organised (white) thrombi showed such characteristics. These results provide objective evidence for the role of thrombosis in the formation of human atherosclerotic plaques.
D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D002455:Cell Division; D002999:Clone Cells / Q000473:pathology; D005260:Female; D005263:Femoral Artery / Q000473:pathology; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D007083:Iliac Artery / Q000473:pathology; D007527:Isoenzymes / Q000032:analysis; D011651:Pulmonary Artery / Q000473:pathology; D013927:Thrombosis / Q000201:enzymology / Q000235:genetics / Q000473:pathology*
D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase