Polymorphic hydroxylation of Debrisoquine in man.
Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the urine of 94 volunteers after a single oral dose of 10 mg debrisoquine. The ratio between excreted debrisoquine and its metabolite was bimorphically distributed in the study population. Family studies supported the view that alicyclic 4-hydroxylation of debrisoquine is controlled by a single autosomal gene and that a defect in this metabolic step is caused by a recessive allele.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000483:Alleles; D001682:Biological Availability; D055598:Chemical Phenomena; D002621:Chemistry; D002648:Child; D003647:Debrisoquin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000652:urine*; D005260:Female; D005808:Genes, Recessive; D005838:Genotype; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000652:urine*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics; D008875:Middle Aged
D007546:Isoquinolines; D003647:Debrisoquin