title: HLA and cell-mediated immunity in HBsAg negative chronic active hepatitis.
abstract: In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic immunoregulatory action might be involved in the pathogenetic mechanisms of chronic active hepatitis in vivo.
mesh_terms: D000328:Adult; D002908:Chronic Disease; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006505:Hepatitis / Q000276:immunology*; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged
chemical_list: D000939:Epitopes; D006680:HLA Antigens; D006514:Hepatitis B Surface Antigens