Release of immuno-reactive and biologically active LH from fetal mouse pituitary in response to synthetic gonadotropin releasing factor (LRF).
In an incubation system, LRF stimulated significantly the release of LH from 18-day-old mouse fetal pituitary. This LRF-induced LH release, measured by RIA in the incubation medium was able to increase the testosterone production by age-matched fetal testes. This data suggests that the hypothalamo-hypophyseal-testicular axis is functional at the end of mouse prenatal life.
D000818:Animals; D000939:Epitopes; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D010902:Pituitary Gland / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism
D000939:Epitopes; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone