title: Karyotypic conversion in Ph1-positive chronic myeloid leukaemia with combination chemotherapy.
abstract: Twelve previously untreated patients with Ph1-positive chronic myeloid leukaemia received combination chemotherapy soon after diagnosis. There was karyotypic conversion in five: in four, the percentage of Ph1-positive cells fell to 10 or less. In two other patients, who had mosaic karyotypes at presentation, the percentage fell to 5% and zero.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002904:Chromosomes, Human, 21-22 and Y; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D012075:Remission, Spontaneous; D014178:Translocation, Genetic
chemical_list: D000970:Antineoplastic Agents