title: Towards a unified theory for immunogenetic systems. Some selected properties of ABC- and AB-D reaction patterns generated by S3 and T3 universes.
abstract: The principles of a radically new unified theory and a unified but fundamentally theory-invariant classification system are described and exemplified for immunogenetic systems. The classification system permits a differentiation of immunogenetic systems into 15 qualitatively distinct classes with quantitative subsets when tested against two reagents. It can easily be expanded into a n-reagent taxonomy. The theory logically explains a set of selected and previously more or less "unexplainable" properties and their (even more unexplainable and probably previously unnoticed) associations in two main classes of immunogenetic systems, the ABC- and AB-D systems. The associated properties discussed are the presence (+) or absence (-) of: 1. antithetical alleles; 2. dosage effects; 3. inherited "strong" and "weak" antigens; 4. "silent" or "amorphous" genes. In ABC- systems, properties 1 and 2 are present while 3 and 4 are absent or extremely rare (i.e. 1+2+3-4-). In AB-D systems, properties 1 and 2 are absent while 3 and 4 are present (i.e. 1-2-3+4+). Through the design of hypothetical immunogenetic universes (HIU), these property associations are shown to be produced by the contemporary (simple-complex) framework-dependent transformations of experimental observables/matrix facts and not by any corresponding associated properties present in the input HIU in themselves.
mesh_terms: D000017:ABO Blood-Group System; D000483:Alleles; D000918:Antibody Specificity; D001789:Blood Group Antigens; D000939:Epitopes; D005838:Genotype; D006801:Humans; D007125:Immunogenetics / Q000145:classification*; D007518:Isoantibodies; D007519:Isoantigens; D008433:Mathematics; D008954:Models, Biological; D010127:P Blood-Group System; D010641:Phenotype; D012204:Rh-Hr Blood-Group System
chemical_list: D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D000939:Epitopes; D007518:Isoantibodies; D007519:Isoantigens; D010127:P Blood-Group System; D012204:Rh-Hr Blood-Group System