Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism.
A 57-year-old woman with hypertension and moderate renal insufficiency had chronic unexplained hyperkalaemia. Metabolic balance studies confirmed a diagnosis of hyporeninaemic hypoaldosteronism. Two observations suggested that impaired renal prostaglandin production contributed to the pathogenesis of the patient's disorder. Baseline renal-prostaglandin synthesis (as determined by urinary excretion of P.G.E and P.G.F) was was substantially depressed when compared with that in nine normal females. Infusion of low doses of P.G.A1 produced a significant increase in serum-aldosterone and urinary potassium excretion; it also led to a dramatic fall in blood-pressure and serum-potassium. It appears from these studies that a defect in renal prostaglandin synthesis has an important role in the pathogenesis of hyporeninaemic hypoaldosteronism.
D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D000450:Aldosterone / Q000172:deficiency* / Q000378:metabolism; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000652:urine; D011460:Prostaglandins F / Q000096:biosynthesis* / Q000652:urine; D012083:Renin / Q000097:blood / Q000172:deficiency*; D012964:Sodium / Q000378:metabolism
D011458:Prostaglandins E; D011460:Prostaglandins F; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium