[Abolition by naloxone of the inhibitory effect of peripheral electrical stimulation on the blink reflex].
The effects of a low frequency (2 c/sec) peripheral stimulation (electro-acupuncture, EA) on the nociceptive (R2) response of the blink reflex elicited by supra-orbital nerve stimulation (0.1 msec, 1 shock/8 sec) were studied in 10 healthy subjects. EA stimulation produced a very significant inhibition of the reflex in 8 subjects. Double-blind injection of naloxone (0.8 mg) reversed this inhibition while no signiificant change was observed with placebo. These results suggest that EA stimulation induces the release of endogenous opiates.
D000328:Adult; D003391:Cranial Nerves / Q000502:physiology; D004558:Electric Stimulation; D005143:Eyelids / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009892:Opium / Q000378:metabolism; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
D009270:Naloxone; D009892:Opium
Abolition par la naloxone de l'effet inhibiteur d'une stimulation électrique périphérique sur la composante tardive du réflexe de clignement.