The effect of sexual hormones on skin graft survival, thymic morphology and serum levels of glycoproteins and albumin in mice.
Inbred mice of the B10LP strain were injected subcutaneously over a period of 28 days with chloromadinone acetate, mestranol, both hormones together, and the carrier alone. Treatment with the gestagen chloromadinone acetate alone or in combination with mestranol caused a significant prolongation of the H-2 different skin graft survival. This was not seen after mestranol treatment alone. All the hormone-treated mice developed characteristic cysts in the thymic medulla and changes in the concentration of some plasma proteins, e.g. a fall of albumin level and a simultaneous increase of glycoprotein level. Therefore, it is necessary to look for such side-effects in humans also to prevent or to notice early alterations of immunological surveillance.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002715:Chlormadinone Acetate / Q000494:pharmacology; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006085:Graft Survival / Q000187:drug effects*; D008656:Mestranol / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D016038:Skin Transplantation; D013950:Thymus Gland / Q000187:drug effects*; D014184:Transplantation, Homologous
D001798:Blood Proteins; D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D006023:Glycoproteins; D012709:Serum Albumin; D002715:Chlormadinone Acetate; D008656:Mestranol