The influence of smoking on the haemostatic mechanism in pregnancy.
A prospective study through pregnancy is described comparing smokers with non-smokers in an attempt to assess possible changes in the haemostatic mechanism. Various components of the coagulation and fibrinolytic enzyme systems were assayed serially up to 38 weeks of gestation. Plasma fibrinogen was lower in the smokers than in the non-smokers. Also plasminogen was slightly decreased and plasminogen activator activity and serum F.D.P. increased in the former group. Although the results failed to demonstrate motor disseminated intravascular coagulation in smokers, the pattern of a possible low grade syndrome emerged.
D000328:Adult; D000991:Antithrombins / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D010958:Plasminogen / Q000032:analysis; D010960:Plasminogen Activators / Q000097:blood; D011247:Pregnancy; D011446:Prospective Studies; D012907:Smoking / Q000503:physiopathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000991:Antithrombins; D005338:Fibrin Fibrinogen Degradation Products; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D005340:Fibrinogen; D010958:Plasminogen; D010960:Plasminogen Activators