Crossed immunoelectrofocusing of cerebrospinal fluid immunoglobulins.
The combination of the high separation capacity of isoelectric focusing and the specificity of immunoelectrophoresis gives a valuable tool for protein studies. This technic can be applied to immunoglobulin examinations by using KOCN-treated antibodies isoelectric at pH 5 and performing the immunoelectrophoretic procedure at this pH. CSF and serum samples of patients exhibiting CSF immunoglobulin abnormalities and blood-CSF barrier damages were examined by this method.
D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006801:Humans; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000032:analysis*; D007525:Isoelectric Focusing
D002556:Cerebrospinal Fluid Proteins; D007136:Immunoglobulins