Influence of once-daily administration of beta-adrenoceptor antagonists on arterial pressure and its variability.
Intra-arterial pressure was recorded over 24 h in hypertensive patients before and during long-term treatment with beta-adrenoceptor antagonists given once daily under standardised conditions. Arterial pressure was reduced throughout the 24 h after the last dose as was variability of pressure during physical activity; variability during sleep and rest did not change significantly.
D000070:Acebutolol / Q000008:administration & dosage* / Q000494:pharmacology; D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D001510:Bed Rest; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D005082:Physical Exertion; D011412:Propanolamines / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage* / Q000494:pharmacology; D012890:Sleep / Q000502:physiology; D013599:Systole
D011412:Propanolamines; D000070:Acebutolol; D011433:Propranolol; D008790:Metoprolol