Correction of renal hypertension in the rat by prolonged infusion of angiotensin inhibitors.
Injection of saralasin or converting-enzyme inhibitor produced a small variable reduction of blood-pressure in rats with two-kidney hypertension. Prolonged infusion of the inhibitors gradually reduced blood-pressure to normal. Control infusions of saralasin in normal animals and of dextrose in normal and hypertensive animals did not reduce blood-pressure. Plasma-renin concentration correlated significantly with the early but not with the later fall of blood-pressure. Plasma-concentrations of renin and angiotensin II were closely related except in rats receiving converting-enzyme inhibitor, when angiotensin II was relatively reduced. The gradual reduction of arterial pressure by saralasin was not associated with increased urinary sodium excretion.
D000803:Angiotensin I / Q000627:therapeutic use; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use; D006977:Hypertension, Renal / Q000097:blood / Q000188:drug therapy*; D007263:Infusions, Parenteral; D051381:Rats; D012083:Renin / Q000097:blood; D012504:Saralasin / Q000008:administration & dosage* / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D000803:Angiotensin I; D012083:Renin; D012504:Saralasin; D005947:Glucose