Biochemical and haematological changes induced by tienilic acid combined with propranolol in essential hypertension.
Sixteen patients with moderate essential hypertension completed a double-blind crossover trial with four treatment periods each of 6 weeks. They received in random order: placebo; tienilic acid 250 mg/day; propranolol 80 mg twice daily; and tienilic acid 250 mg/day combined with propranolol 80 mg twice daily. Average blood-pressure in the lying position was 22.6/13.1 kPa (169/98 mm Hg) on placebo; 21.0/12.5 (157/94) on tienilic aicd; 21.2/12.0 (159/90) on propranolol, and 18.9/11.5 (142/86) on tienilic acid combined with propranolol. The effects of tienilic acid and propranolol on blood-pressure were additive and there were no statistically significant interactions. Tienilic acid significantly reduced serum-urate from 0.33 to 0.18 mmol/l and induced hypokalaemia which was corrected by propranolol. Basophil count and haemoglobin were lower after tienilic acid treatment than they had been at the start of the study.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001799:Blood Sedimentation; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000008:administration & dosage*; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006016:Glycolates / Q000008:administration & dosage*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010642:Phenoxyacetates / Q000008:administration & dosage*; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
D004232:Diuretics; D006016:Glycolates; D006454:Hemoglobins; D010642:Phenoxyacetates; D013876:Thiophenes; D014527:Uric Acid; D014508:Urea; D011433:Propranolol; D003404:Creatinine; D011188:Potassium