Non-A, non-B post-transfusion hepatitis.
To clarify the role of hepatitis-A virus (H.A.V.) in the aetiology of post-transfusion hepatitis unrelated to hepatitis-B virus, we have tested and titred pre-transfusion and convalescent serum samples from 32 patients for antibody to hepatitis-A antigen (anti-HA) by quantitative immune adherence haemagglutination. 12 patients had no detectable anti-HA in either pre-transfusion or late convalescent serum; the other 20 had anti-HA in pretransfusion serum and no significant chance in titre during convalescence. This study excludes H.A.V. as the agent responsible for these cases of post-transfusion hepatitis and supports the existence of "non-A, non-B" hepatitis virus(es).
D000914:Antibodies, Viral / Q000302:isolation & purification; D000956:Antigens, Viral / Q000302:isolation & purification; D006386:Hemagglutination Tests; D006506:Hepatitis A / Q000382:microbiology; D006509:Hepatitis B / Q000382:microbiology; D006511:Hepatitis B Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000209:etiology* / Q000382:microbiology; D006507:Hepatovirus / Q000276:immunology; D007104:Immune Adherence Reaction; D065227:Transfusion Reaction
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006511:Hepatitis B Antigens