HLA-A1, B8-phenotype association and HBs antigenemia evolution in 440 hemodialyzed patients.
HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HL-A-A1, B8 association (18.6%) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population (5.05%, p less than 10(-4), and with the group of patients unable to eliminate HBsAg (7.0%,  less than 0.01). Chronic aggressive hepatitis was only found in the latter. This high frequency of the HLA-A1, B8 association has also been found in patients with seronegative active chronic hepatitis and suggests that this phenotype might be associated with high immune response against HBsAg.
D002908:Chronic Disease; D000939:Epitopes; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000032:analysis; D006505:Hepatitis / Q000276:immunology; D006511:Hepatitis B Antigens / Q000032:analysis; D006525:Hepatitis, Viral, Human / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D010641:Phenotype; D006435:Renal Dialysis; D014511:Uremia / Q000276:immunology / Q000628:therapy
D000939:Epitopes; D006680:HLA Antigens; D006511:Hepatitis B Antigens; D006649:Histocompatibility Antigens