Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex.
CBA/N mice have an X-linked recessive effect that results in the absence of a subpopulation of B cells carrying the Lyb3 surface marker. It has been shown previously that this marker is present on a mature subset of B cells in all mouse strains. In this paper the Lyb3+ B cell population in C57BL/6 mice was analyzed further. This subset of B cells selectively expresses a surface marker controlled by the I-A subregion of the H-2 complex. A cytotoxic antiserum recognizing this marker was raised by immunizing defective (CBA/N X C57BL/6)F1 male mice with C57BL/6 spleen cells. This antiserum also contained noncytotoxic, non-strain-restricted anti-Lyb3 antibodies. The possible functional relevance of this surface marker is discussed.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001402:B-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005802:Genes, MHC Class II; D005819:Genetic Markers; D006183:H-2 Antigens / Q000235:genetics*; D007518:Isoantibodies; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D000954:Antigens, Surface; D000939:Epitopes; D005819:Genetic Markers; D006183:H-2 Antigens; D007518:Isoantibodies