Strong association between B-lymphocyte group-2 specificity and asthma.
30 families in which at least one member has asthma were tested for five new specificities of B lymphocytes as well as for twenty-five HLA antigens. 41 other asthmatic patients were also tested. HLA-B8 was slightly less common than normal in the 71 patients with asthma and there was a trend towards an increased frequency of HLA-A2 in these patients. However, 88% of the 30 asthma patients had B lymphocyte group 2 compared with 24% of the 109 controls. This strong association between asthma and B lymphocyte group 2 was not completely paralleled by linkage with a postulated susceptibility gene of the HLA complex in 9 families whose members were investigated in detail.
D000328:Adult; D000483:Alleles; D001249:Asthma / Q000235:genetics* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D000939:Epitopes; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens; D006238:Haploidy; D006649:Histocompatibility Antigens; D006801:Humans; D008297:Male
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens