Effects of verapamil in ventricular premature beats of acute myocardial infarction.
In 8 patients affected with acute myocardial infarction verapamil was highly effective in controlling ventricular extrasystoles. Theoretically the drug ought not to be effective if the extrasystoles were related to fast cardiac fibers characterized by a rapid inward Na+ current. The result suggests that in acute myocardial ischemia ventricular extrasystoles are related to slow inward Ca++ currents.
D000368:Aged; D002118:Calcium / Q000378:metabolism; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000209:etiology; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D012964:Sodium / Q000378:metabolism; D014700:Verapamil / Q000627:therapeutic use*
D012964:Sodium; D014700:Verapamil; D002118:Calcium