Denaturization of allergen P: effect on allergenicity, antigenicity and immunogenicity.
When allergen P was denatured by 8M urea, the modified molecule still reacted with IgE specific for the native allergen but not with hemagglutinating antibodies. Heating at 100 degrees C abolished the reaction in both cases. The results suggested differences between allergenic and antigenic capacities which may be based on structural differences of the antigenic determinants.
D000485:Allergens / Q000276:immunology* / Q000528:radiation effects; D000818:Animals; D000941:Antigens / Q000276:immunology*; D004220:Disulfides / Q000378:metabolism; D006636:Histamine Release; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008407:Mast Cells / Q000276:immunology; D011852:Radioallergosorbent Test; D051381:Rats; D014197:Trees / Q000276:immunology*; D014466:Ultraviolet Rays; D014508:Urea / Q000494:pharmacology
D000485:Allergens; D000941:Antigens; D004220:Disulfides; D014508:Urea