HLA and mycobacterial infection: increased frequency of B8 in Japanese leprosy.
A total of 60 leprosy patients, 28 of lepromatous and 32 of tuberculoid form, and 70 active tuberculosis patients was compared with a control of 184 for 34 HLA specificities. The most interesting finding was an increased frequency (10.0%) for HLA-B8 (corrected P = 0.062, relative risk = 20.3) in the leprosy patients as compared with the control group, despite the fact that the frequency of HLA-B8 was extremely low in Japanese. Furthermore, all leprosy patients with B8 had leprous member(s) in their family.
D000328:Adult; D000368:Aged; D000939:Epitopes; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007564:Japan; D007918:Leprosy / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D010641:Phenotype; D014376:Tuberculosis / Q000235:genetics
D000939:Epitopes; D006680:HLA Antigens