Fc-rosette inhibition by pregnant women's sera and by rabbit anti-beta2-microglobulin.
Some anti-HLA sera showed Fc-rosette inhibitory activity, which had little correlation with type-specific anti-HLA activity. Cytotoxic titers did not correlate with Fc-rosette inhibition rate and these antisera showed considerable inhibition of rosette formation even after absorption of anti-HLA activity with T lymphocytes. These results suggest that some anti-HLA sera contain B-cell-specific inhibitory activity against Fc-receptor like anti-Ia antibody in mice. Rabbit antiserum against human beta2-microglobulin showed specific inhibition of Fc-rosette formation. It was suggested that Fc-receptor or Ia-like antigen in human has a close relation with beta2-microglobulin.
D000818:Animals; D000906:Antibodies; D001609:Beta-Globulins / Q000276:immunology*; D001769:Blood; D005260:Female; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D011247:Pregnancy; D011817:Rabbits; D012397:Rosette Formation; D001613:beta 2-Microglobulin / Q000276:immunology*
D000906:Antibodies; D001609:Beta-Globulins; D007141:Immunoglobulin Fc Fragments; D001613:beta 2-Microglobulin