Expression of Ia determinants on immunocompetent cells.
The expression of Ia (immune response region-associated) antigens on the surface of lymphocyte subpopulations with defined immunological function has been investigated by negative selection of subpopulations with anti-Ia sera and complement. Ia determinants were found on both unprimed (IgM) and on primed (IgG) antibody-forming precursor cells. No Ia antigens were detected on the surface of helper T cells. In contrast, suppressor T cells were sensitive to treatment with anti-Ia sera and complement demonstrating the presence of Ia determinants on this T cell subpopulation.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D000939:Epitopes; D005796:Genes; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D051379:Mice; D008805:Mice, Inbred A; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens; D012710:Serum Albumin, Bovine