Inflammation inhibiting properties of rat alphaM foetoprotein (rat-alpha2 macroglobulin), an acute phase reactant.
alphaMFoetoprotein of the rat (rat alpha2macroglobulin) is present in serum during foetal development. After birth, alphaMFP declines rapidly, but the protein returns after injury. The injury we used consisted of skin and muscle incision, laparotomy, BaSO4 i.p. The protein occurs also during liverregeneration, livercardinogenesis en during infections. Therefore, alphaMFP can be considered as an acute phase reactant. We found that this protein strongly inhibits inflammatory exudation caused by carrageenin, histamin, prostaglandin E2, 5HT and bradykinin. Furthermore, we found that alphaMFP suppresses completely inflammatory reactions during Ga1.N-hepatitis. In this condition, the primary biochemical lesion, consisting of liver UDPG depletion, does occur in spite of the protective effect of alphaMFP. Thus, the inflammatory inhibiting effects of alphaMFP seem to be an important mechanism reducing inflammatory reaction patterns.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001920:Bradykinin / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D004487:Edema / Q000503:physiopathology; D005688:Galactosamine; D006632:Histamine / Q000378:metabolism; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D011458:Prostaglandins E; D000511:alpha-Macroglobulins; D012701:Serotonin; D005688:Galactosamine; D006632:Histamine; D001920:Bradykinin