Laryngeal malignancy following iodine-125 therapy for thyrotoxicosis.
A 52-year-old woman presented with a laryngeal sarcoma eight years after receiving two doses, each of 30 mCi, of iodine-125 for thyrotoxicosis. That extrathyroidal tissue receives a higher radiation dose of low-energy photon radiation from iodine-125 than from an equivalent microcurie dose of iodine-131 and that the tumour was of a type which rarely arises spontaneously in the larynx suggest a possible link between the development of the tumour and iodine-125 therapy.
D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors
D007457:Iodine Radioisotopes