Phototoxic reaction to chlorpromazine as studied with the quantitative mouse tail technique.
A quantitative in vivo technique for the study of the phototoxic reaction to systemic chlorpromazine has been developed, based on the increasing tissue fluid content of the albino mouse tail. A maximum increase in tissue fluid of about 25% was registered 24 hours after starting the long-wave ultraviolet light exposure. The minimum phototoxic dose of chlorpromazine was 2.5 mg/kg.
D000818:Animals; D002746:Chlorpromazine / Q000633:toxicity*; D005260:Female; D008722:Methods; D051379:Mice; D009929:Organ Size; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D013623:Tail
D002746:Chlorpromazine