Chromosome aberrations and sister-chromatid exchange in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory workers.
Cultured lymphocytes from 73 workers in chemical laboratories and the printing industry were found to have a significantly increased frequency of chromatid and isochromatid breaks, in comparison with 49 control subjects (42 adults and 7 children). An increase of the same magnitude was also found in 14 children, aged 4 days--11 yr, of 11 women laboratory workers who had worked during pregnancy. A significant correlation between age and frequency of chromosome aberrations was noted for both the exposed and control children but not for the adults. The frequency of sister-chromomatid exchange was significantly increased in 12 technicians working in laboratories performing hormone analysis. 4 children of 2 female technicians working during pregnancy also had a significnatly increased frequency of sister-chromatid exchange. The cause and biological significance of these findings are not yet known.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000494:pharmacology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002842:Chromatids / Q000032:analysis* / Q000187:drug effects; D002869:Chromosome Aberrations; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007753:Laboratories; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D009784:Occupational Diseases; D011247:Pregnancy; D011327:Printing; D012997:Solvents / Q000009:adverse effects / Q000494:pharmacology; D013548:Sweden
D000395:Air Pollutants, Occupational; D012997:Solvents