[Insensitivity to pain: electrophysiological study of the nociceptive reflex. Influence of naloxone (author's transl)].
Electrophysiological studies of the nociceptive reflex (R3) were carried out in eight normal subjects, and one patient with congenital insensitivity to pain, in order to compare the effects of naloxone and a placebo. No significant variation in the reflex threshold was seen in the normal subjects. Two electrophysiological abnormalities were observed in the patient: a 350 per cent spontaneous elevation in the R3 threshold compared to the control group; a rapid and large drop (67 per cent) in the threshold lasting for about ten minutes after the injection of Naloxone. These results suggest that in this particular case the insensitivity to pain could be related to the permanent hyperactivity of a morphine-like inhibitory system.
D000328:Adult; D004723:Endorphins / Q000378:metabolism; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects / Q000503:physiopathology*; D000699:Pain Insensitivity, Congenital / Q000503:physiopathology*; D010919:Placebos; D011957:Receptors, Opioid / Q000187:drug effects; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D012684:Sensory Thresholds / Q000187:drug effects
D004723:Endorphins; D010919:Placebos; D011957:Receptors, Opioid; D009270:Naloxone; D005283:Fentanyl
Insensibilité à la douleur: étude électrophysiologique du réflexe nociceptif. Influence de la naloxone.