title: The specific reduction of a and d antigenic determinants after periodate treatment of hepatitis B surface antigen (HBsAg).
abstract: HBsAg antigenicity was found to be sensitive to periodate treatment. Antigenic determinants a and d were especially sensitive, losing almost all of their activity, while determinants r and w were found to be quite stable. Also, it is now possible to prepare the monospecific antibodies, anti-r and anti-w, by the use of this new, simpler procedure.
mesh_terms: D000918:Antibody Specificity; D000939:Epitopes / Q000302:isolation & purification; D006511:Hepatitis B Antigens; D010504:Periodic Acid / Q000494:pharmacology*
chemical_list: D000939:Epitopes; D006511:Hepatitis B Antigens; D010504:Periodic Acid