title: The measurement of pain in terminal carcinoma.
abstract: 1. A method is described for comparing narcotic analgesics and adjuvants in patients with terminal cancer. 2. A randomized controlled trial of orally administered diamorphine and morphine is reported to illustrate the method. 3. It is concluded that there is no over-all clinical difference between diamorphine and morphine when administered by mouth every four hours at individually optimized doses in association with cocaine and a phenothiazine. 4. The validity, reliability and sensitivity of the method are discussed.
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation / Q000379:methods; D005260:Female; D003932:Heroin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008722:Methods; D009020:Morphine / Q000627:therapeutic use; D009369:Neoplasms / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy*; D010166:Palliative Care; D011795:Surveys and Questionnaires; D013727:Terminal Care
chemical_list: D000701:Analgesics, Opioid; D003932:Heroin; D009020:Morphine