title: NMR observation of gramicidin A' in phosphatidylcholine vesicles.
abstract: Dimyristoyl phosphatidylcholine was prepared with perdeuterated hydrocarbon chains and sonicated into bilayer vesicles together with gramicidin A'. The 1H NMR resonance from the tryptophan residues in the gramicidin has a linewidth of approximately 80 Hz, indicating significant local mobility for these residues. Paramagnetic lanthanides added to the aqueous medium cause a chemical shift of this signal indicating that some of the tryptophans may be located in the interfacial region of the bilayer.
mesh_terms: D006096:Gramicidin; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008567:Membranes, Artificial; D008954:Models, Biological; D009227:Myristic Acids; D010713:Phosphatidylcholines; D013932:Thulium; D014364:Tryptophan; D015019:Yttrium
chemical_list: D008567:Membranes, Artificial; D009227:Myristic Acids; D010713:Phosphatidylcholines; D006096:Gramicidin; D015019:Yttrium; D014364:Tryptophan; D013932:Thulium