[Antigenic determinants of beta-LPH, beta-MSH, alpha-endorphin, ACTH and alpha-MSH revealed by anti-beta-endorphin in neurons of the human infundibular nucleus].
Comparison of adjacent serial sections of the tubero-infundibular region of Human adult hypothalamus demonstrates that the same perikarya, axons and terminals are stained both with anti-beta-endorphin and anti 17-39 ACTH antisera. The most immunoreactive of these neurons are also revealed with anti alpha-endorphin, anti alpha and beta-MSH, anti-1-24 ACTH and anti beta-LPH. These results suggest that neurons of the infundibular nucleus can store and probably secrete peptide similar to propiocortin or fragment(s) of this molecule.
D000324:Adrenocorticotropic Hormone / Q000276:immunology; D000328:Adult; D004723:Endorphins / Q000276:immunology; D000939:Epitopes; D006801:Humans; D007031:Hypothalamus / Q000276:immunology*; D009074:Melanocyte-Stimulating Hormones / Q000276:immunology; D009474:Neurons / Q000276:immunology*; D008083:beta-Lipotropin / Q000276:immunology
D004723:Endorphins; D000939:Epitopes; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin
Présence de déterminants antigéniques de la beta-LPH, de la beta-MSH, de l'alpha-endorphine, de l'ACTH et de l'alpha-MSH dans les neurones révélés par l'anti-beta-endorphine au niveau du noyau infundibulaire de l'Homme.