Diurnal rhythmicity in folic acid metabolism of rat liver and kidney.
In rat liver and kidney, tetrahydrofolate formylase activities show diurnal rhythms with maxima in the middle of the dark phase. The rhythms are not generated by de novo synthesis of enzyme protein. Dihydrofolate reductase activity is arrhythmic in both liver and kidney.
D000818:Animals; D002940:Circadian Rhythm; D003513:Cycloheximide / Q000494:pharmacology; D003624:Darkness; D005492:Folic Acid / Q000378:metabolism*; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D005492:Folic Acid; D003513:Cycloheximide; D013762:Tetrahydrofolate Dehydrogenase; D008025:Ligases; D005574:Formate-Tetrahydrofolate Ligase