Effect of irradiation on thyroid-autoantibody production.
Irradiated lymphocytes have been found to stimulate thyroid-autoantibody synthesis by lymphocyte cultures. It is proposed that a similar effect is involved in the increased autoimmune response which follows radioiodine treatment for Graves' disease.
D000921:Antibody-Producing Cells / Q000528:radiation effects*; D001323:Autoantibodies / Q000096:biosynthesis*; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D006111:Graves Disease / Q000532:radiotherapy; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007457:Iodine Radioisotopes; D011829:Radiation Dosage; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D013954:Thyroglobulin / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D013954:Thyroglobulin