title: Effects of changes in cortical excitability upon the epileptic bursts in generalized penicillin epilepsy of the cat.
abstract: Previous studies had suggested that the epileptic bursts of feline generalized penicillin epilepsy represent the response of hyperexcitable cortex to thalamocortical volleys normally evoking spindles. If this were the case, it should be possible to convert the epileptic bursts of generalized penicillin epilepsy into spindles by decreasing the excitability of cortical neurons. In cats exhibiting the EEG signs of feline generalized penicillin epilepsy cortical excitability was decreased by hypoxia, by the topical application to the cortex of KCl (inducing spreading depression), barbiturates, GABA, AMP or noradrenaline. During generalized penicillin epilepsy, hypoxia and KCl-induced spreading depression abolished epileptic bursts which were replaced by spindles. When spindles and epileptic complexes occurring in the same animal were compared, a direct correlation between the frequencies of these two rhythms could be demonstrated, that of the epileptic complexes being about half that of the spindle waves. These observations support the hypothesis that the epileptic bursts of feline generalized penicillin epilepsy are induced by thalamocortical volleys normally involved in spindle genesis. Topical cortical applications of barbiturates, GABA, AMP and noradrenaline reduced or inverted the negative spikes of the spike and wave complexes, while augmenting the negative slow waves, or revealing them clearly in instances in which they had been poorly developed. This effect is interpreted as being due to a selective inactivation of the superficial cortical layers. That topical cortical application of barbiturates, GABA, AMP and noradrenaline was capable of transforming into typical spike and wave complex epileptic bursts, which had not previously conformed to this pattern, indicates that the intracortical electrophysiological events of typical and atypical epileptic bursts in feline generalized penicillin epilepsy are fundamentally the same and reflect an alternation between excitatory and inhibitory sequences.
mesh_terms: D000249:Adenosine Monophosphate / Q000008:administration & dosage; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D002415:Cats; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D013181:Cortical Spreading Depression / Q000187:drug effects; D003344:Cortical Synchronization; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D002534:Hypoxia, Brain / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D009638:Norepinephrine / Q000008:administration & dosage; D010400:Penicillin G / Q000633:toxicity*; D011188:Potassium / Q000008:administration & dosage; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage
chemical_list: D001463:Barbiturates; D002492:Central Nervous System Depressants; D000249:Adenosine Monophosphate; D005680:gamma-Aminobutyric Acid; D010400:Penicillin G; D011188:Potassium; D009638:Norepinephrine