Lack of linkage between acute intermittent porphyria and the A and B loci of the HLA system.
Forty-six members of a family known to have Porphyria were studied. As the disease is often latent clinically, erythrocyte uroporphyrinogen I synthetase activity was determined to classify the subjects as being healthy or carriers. HLA--A, B, C, Bf, GLO antigens were determined. No linkage between acute intermittent Porphyria and the HLA system was noted in this family.
D000208:Acute Disease; D002874:Chromosome Mapping; D000939:Epitopes; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens; D006801:Humans; D008297:Male; D017118:Porphyria, Acute Intermittent; D011164:Porphyrias / Q000235:genetics* / Q000276:immunology; D011995:Recombination, Genetic
D000939:Epitopes; D006680:HLA Antigens