Immune responses in mice infected with lactic dehydrogenase virus. IV. Functional status of the macrophage during acute LDV infection.
Macrophages from uninfected and lactic dehydrogenase virus (LDV)-infected mice were compared with respect to the affinity and number of their Fc receptors for IgG2a; no differences were found regarding these parameters. When the uptake of DNP-BGG by macrophages from uninfected and acutely LDV-infected mice was compared, again no differences were observed. However, when the per cent membrane-bound DNP-BGG was determined as a function of time after antigen uptake in these two groups, more DNP-BGG was found membrane-bound on the macrophages from the LDV-infected mice, than on uninfected macrophages. In view of the fact that humoral immunity is enhanced during acute LDV infection, these data provide a positive correlation between increased retention of membrane-bound antigen and enhanced humoral immune responses.
D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000941:Antigens; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007772:Lactate dehydrogenase-elevating virus / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D014777:Virus Diseases / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D000914:Antibodies, Viral; D000941:Antigens; D004136:Dinitrobenzenes; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D005719:gamma-Globulins