The nature of prostaglandin-like substances released from guinea-pig lung in anaphylaxis.
The pulmonary inactivation of infused prostaglandin E2 by isolated perfused lungs of guinea pigs was inhibited with di-4 phloretin phosphate (DPP) without significantly altering the antigen-induced release of prostaglandin-like substances or histamine. Similar data were obtained when the lungs were perfused in a reverse direction. These results suggest that parent prostaglandins are not major constituents of the prostaglandin-like substances released from guinea-pig lungs during anaphylaxis.
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D003864:Depression, Chemical; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D008168:Lung / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D010693:Phloretin / Q000031:analogs & derivatives / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*
D011458:Prostaglandins E; D010693:Phloretin