[Effectiveness of the tularemia-antibody erythrocyte diagnostic agent for the detection of specific antigen and antibodies to it].
The authors demonstrated the efficacy of utilization of tularemia antibody erythrocytic diagnostic agent. Data are presented indicating a strict specificity and a high sensitivity of this diagnostic agent for detection of the Vi-antigen both in the tularemia microbe cultures and in the suspensions of the organs of rodents which perished of tularemia, irrespective of the state of cadaver. There was revealed relationship between the sensitivity of the diagnostic agent and the virulence of the tularemia microbe cultures. A possibility of using the diagnostic agent in the antigen neutralization test for detection of specific antibodies in the sera of patients, who sustained the disease, and of the vaccinated humans and animals was revealed.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000302:isolation & purification; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005069:Evaluation Studies as Topic; D005604:Francisella tularensis / Q000276:immunology; D006168:Guinea Pigs; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D051379:Mice; D009500:Neutralization Tests / Q000379:methods; D011817:Rabbits; D014406:Tularemia / Q000175:diagnosis* / Q000382:microbiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes
Effektivnost' ispol'zovaniia tuliaremiĭnogo antitel'nogo eritrotsitarnogo diagnostikuma dlia vyiavleniia spetsificheskogo antigena i antitel k nemu.