title: [Complex genesis of anemia in chronic liver diseases].
abstract: 36% of a total of chronic liver patients suffered from anaemia and 50.5% of patients affected with liver cirrhosis. In most cases the anaemias were normochrome and hypochrome or hyperchrome only in some cases. In analyzing possible single factors the reductions of vitamin B12 absorption could be made probable by means of the Schilling test and sometimes a folic acid deficiency in macrocyte anaemia with normal vitamin B12 absorption by determining the folic acid content in the serum and by successes of test treatment 82% of patients with liver cirrhosis showed a latent or manifest haemolysis. However, it was only in 1/3 of the patients with liver cirrhosis that the spleen turned out to be the place of an increased degradation of erythrocytes. In some cases an increased erythrocytoclasia into the liver could be identified. Predominantly, however, an increased degradation of erythrocytes in the total RHS had to be assumed. Twice an ineffective erythropoiesis could be found by ferrokinetic examinations. As a whole ferrokinetic examinations cannot be interpreted easily, because their static and dynamic values of iron transport in the plasma volume of liver patients will undergo considerable changes. Patients with disturbances of haematopoiesis and with haemolysis remaining in the latent stage may develop a manifest anaemia because of the influence of additional factors, such as increase of the plasma volume at lowered haematocrit value or microbleedings. The cause of anaemia cannot be concluded with sufficient probability from the type of anaemia; in a single case all pathogenetic factors will rather have to be analyzed. Therapeutic possibilities for hepatogenous anaemia of complex genesis are discussed.
mesh_terms: D000328:Adult; D000740:Anemia / Q000209:etiology*; D002908:Chronic Disease; D004906:Erythrocyte Count; D004911:Erythrocyte Volume; D005492:Folic Acid / Q000097:blood; D006400:Hematocrit; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications; D008107:Liver Diseases / Q000097:blood / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications*; D009362:Neoplasm Metastasis; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D005492:Folic Acid; D014805:Vitamin B 12
vernacular_title: Zur komplexen Genese der Anämie bei chronischen Lebererkrankungen.