Effect of removal of calcium-activated adenosine triphosphatase from rat mast cells by treatment with sodium glycocholate.
Sodium glycocholate was shown to remove a Ca2+-activated adenosine triphosphatase from the external surface of the rat mast cell without causing lysis. Sensitized mast cells pretreated with sodium glycocholate showed a decrease in histamine-releasing capacity when triggered with antigen, Synacthen and ATP. Release induced by calcium ionophore A23187 was unaffected.
D000251:Adenosine Triphosphatases / Q000172:deficiency*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006000:Glycocholic Acid / Q000494:pharmacology*; D006636:Histamine Release; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats
D000251:Adenosine Triphosphatases; D006000:Glycocholic Acid; D002118:Calcium