Cause of anaemia in malaria.
51Cr studies showed that after complete eradication of malarial parasites erythrocyte life-span is reduced for 4-5 weeks and that the reduction is associated with the presence of complement-containing immune complexes on the red-cell surface. The rate of erythrophagocytosis in the spleen is increased during this period. 59Fe studies of erythropoiesis indicated a mild degree of marrow depression. A very important factor causing anaemia in malaria appears to be a complement-mediated immune process.
D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D001327:Autoimmune Diseases; D003165:Complement System Proteins / Q000276:immunology; D004906:Erythrocyte Count; D004910:Erythrocyte Membrane / Q000276:immunology; D004912:Erythrocytes / Q000473:pathology; D004920:Erythropoiesis; D006461:Hemolysis; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology*; D008288:Malaria / Q000097:blood / Q000276:immunology*; D010963:Plasmodium falciparum; D010966:Plasmodium vivax
D003165:Complement System Proteins