Induction of leukochemotaxis by peptidoglycan of Staphylococcus aureus.
Leukochemotactic activity of staphylococcal peptidoglycan and isolated, specified fragments has been studied. The D-Ala-D-Ala group of the pentapeptide was found to be the major cytotaxigen, and C5a to be the dominant cytotaxin. A molecular weight of about 2,000 appeared to be a critical lower limit for inducing chemotactic response, the highest effect being observed with a fragment having a molecular weight of 3,000. The effect seems to depend on the kind of available antigenic determinants in the fragments and the proportion of specific antibodies in the complement source.
D000818:Animals; D000906:Antibodies; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D000939:Epitopes; D007106:Immune Sera; D007958:Leukocyte Count; D008970:Molecular Weight; D010457:Peptidoglycan / Q000276:immunology / Q000494:pharmacology*; D011817:Rabbits; D013211:Staphylococcus aureus
D000906:Antibodies; D000939:Epitopes; D007106:Immune Sera; D010457:Peptidoglycan