Responsiveness to HY antigen Ir gene complementation and target cell specificity.
The H-2 restricted nature of the cytotoxic T cell responses to the HY antigen in mice has been reviewed, together with mapping data for the H-2 K and/or D association of responses to male cells of the following haplotypes: H-2b, H-2d, H-2k, H-2s. Ir gene complementation is implicated in the HY response of a number of F1 mice derived from non-responder parental haplotypes, and in one recombinant strain. Thus, at least two and possibly more Ir genes are involved in the anti-HY response, in addition to the K and/or D gene products with which HY is obligatorily associated, certainly at the target cell level.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002874:Chromosome Mapping; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005260:Female; D005816:Genetic Complementation Test; D006238:Haploidy; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens