Effect of histamine receptor antagonists on bile damage to the gastric mucosa of canine Heidenhain pouches.
The net ionic fluxes of H+ and Na+ were examined in Heidenhain pouches during damage with sodium taurocholate solution. The increase in ionic flux which occurred with taurocholate could be prevented in animals given H1 and H2 histamine antagonists in combination. The results suggest that histamine mediates changes in the transmucosal ionic flux produced by bile acid.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004285:Dogs; D005753:Gastric Mucosa / Q000503:physiopathology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials / Q000187:drug effects; D008785:Metiamide / Q000494:pharmacology; D011738:Pyrilamine / Q000031:analogs & derivatives / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D013656:Taurocholic Acid / Q000009:adverse effects* / Q000502:physiology
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D008785:Metiamide; D013656:Taurocholic Acid; D012964:Sodium; D011738:Pyrilamine