A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression.
It has previously been shown that J.H., a human leukocyte antigen (HLA)-Dw2 homozygous multiparous woman, fails to respond in a mixed lymphocyte reaction (MLR) to her Dw1 homozygous husband W.H., and that her T cells suppress the responses of HLA matched responders to W.H. The present studies take advantage of the observation that J.H. suppressor cells resist a dose of gamma-irradiation which functionally eliminates her MLR responder cells. J.H. cells, depleted of alloreactive cells, suppress the responses of Dw2 heterozygous or homozygous cells to W.H., regardless of their associated HLA-A or B antigens. Only when W.H. or a few other cells are present as the irradiated stimulator is J.H. suppression of Dw2 responses detected. Thus, the J.H. suppressor T cell recognizes determinants in the irradiated stimulator cells as well as D locus products in the responder.
D004307:Dose-Response Relationship, Radiation; D000939:Epitopes; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007165:Immunosuppression Therapy; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010641:Phenotype; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D000939:Epitopes; D006680:HLA Antigens