title: [The effect of pesticide combinations in laboratory rats. III. Modification of selected enzymes].
abstract: After oral administration of pesticides Parathion-methyl, Carbaryl, Lindane and their combinations were investigated the activities of enzyme SGOT, SGPT, Alkaline Phosphatase and Cholinesterase. Results concerning SGOT-activity demonstrated a significant increase in all groups. The cause of this rise can be found in its effect on liver, muscle and/or heart. The activity of cholinesterase is significantly lower in the combinations of Parathion-methyl/Lindane, Lindane/Carbaryl and Carbaryl/Parathion-methyl. In future the extent of these investigations concerning the subacute toxicity, chronical toxicity, the additive or cumulative effects of pesticide--combinations, combinations of pesticides with drugs and/or xenobiotics etc. must be enhanced in any case.
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D012721:Carbaryl / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D001556:Hexachlorocyclohexane / Q000633:toxicity; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008743:Methyl Parathion / Q000633:toxicity; D051381:Rats
chemical_list: D007306:Insecticides; D008743:Methyl Parathion; D001556:Hexachlorocyclohexane; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase; D012721:Carbaryl
vernacular_title: Untersuchungen zur Wirkung von Pestizidkombinationen auf die Laboratoriumsratte. 3. Mitteilung: Untersuchungen zur Beeinflussung von ausgewählten Fermenten.