Reduced severity of lesions in mink infected transplacentally with Aleutian disease virus.
Inoculation of mink late in the second trimester of pregnancy with Aleutian disease virus (ADV) produces a persistent infection in the offspring. When these mink were analyzed at 83 days of age and compared with adolescent mink infected for a similar length of time, the transplacentally infected mink show: 1) a marked reduction in plasmacytosis, immunoglobulin level and specific ADV antibody; 2) increased amounts of infectious ADV and numbers of cells containing viral antigen; 3) a marked reduction in immune complex glomerulonephritis and absence of immune complex arteritis; 4) free ADV antigen in the glomeruli; and 5) a striking accumulation of eosinophils in the tissues. The findings suggest that the degree of ADV expression is partially immunologically controlled.
D000375:Aging; D000453:Aleutian Mink Disease / Q000276:immunology*; D000454:Aleutian Mink Disease Virus / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral; D001167:Arteritis / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008907:Mink; D010950:Plasma Cells / Q000473:pathology; D011247:Pregnancy; D005719:gamma-Globulins / Q000032:analysis
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G; D005719:gamma-Globulins