title: Synthesis of 5''-amino-3,5''-dideoxybutirosin A.
abstract: The titled compound was prepared by condensation of 3'-deoxyparomamine derivative (5) with 2,3-O-bis(p-nitrobenzoyl)-5-O-tosyl-D-xylofuranosyl bromide followed by 1-N-acylation with the active ester of (S)-4-benzyloxycarbonylamino-2-hydroxybutyric acid. The compound was slightly more active than 3'-deoxybutirosin A against Pseudomonas.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002076:Butirosin Sulfate / Q000138:chemical synthesis* / Q000494:pharmacology; D008722:Methods; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002076:Butirosin Sulfate