A suppressor T cell in the human mixed lymphocyte reaction.
Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.
D002478:Cells, Cultured; D000939:Epitopes; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006720:Homozygote; D006801:Humans; D007158:Immunologic Techniques; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens