[The influence of 6-mercaptopurine on the humoral immune response in guinea pig. 1. The importance of antigen and adjuvans (author's transl)].
Following an intradermal immunization of guinea pigs with dinitrophenylated bovine gamma globulin (DNP23-BGG), human serum albumin (HSA) and trinitrophenylated sheep red blood cells (TNP-SRBC) emulsified in complete or in incomplete Freund's adjuvans the effectivity of 6-mercaptopurine (6-MP) on the formation of specific antibodies was investigated. By application of 10 mg 6-MP/kf/day--in guinea pigs a significant depression of antibody formation against BGG could be demonstrated if treatment is started on the day of antigen injection and continued for seven days. The production of anti-SRBC agglutinating antibodies was only suppressed if the antigen was injected together with complete Freund's adjuvans. The anti-DNP and anti-HSA antibody formation was not influenced by this kind of immunosuppressive treatment.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D000941:Antigens; D002417:Cattle; D004912:Erythrocytes / Q000276:immunology*; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006801:Humans; D007165:Immunosuppression Therapy; D015122:Mercaptopurine / Q000494:pharmacology*; D012709:Serum Albumin / Q000276:immunology; D012756:Sheep; D005719:gamma-Globulins
D000941:Antigens; D012709:Serum Albumin; D005719:gamma-Globulins; D005620:Freund's Adjuvant; D015122:Mercaptopurine
Der Einfluss von 6-Merkaptopurin auf die humorale Immunantwort des Meerschweinchens. 1. Die Bedeutung von Antigen und Adjuvans