title: Operating room nurses' psychomotor and driving skills after occupational exposure to halothane and nitrous oxide.
abstract: Concentrations of halothane and nitrous oxide were assayed by gas chromatography throughout a working day in three operating theatres and in the end-tidal air of 19 nurses 15 and 60 min after leaving the theatres. Perceptual, psychomotor and driving skills were measured in these nurses and in 11 younger nurses working in the wards of the same hospital. A complicated psychomotor test battery and a driving simulator were used. End-tidal air concentrations of halothane and nitrous oxide were positively correlated with the exposure level of these gases in the operating theatres. Some of the operating room nurses had greater amounts of halothane in their end-tidal air (average 15 to 10 ppm) than student volunteers 4.5 h after 3.5 min of general anaesthesia with a combination of halothanenitrous-oxide oxygen (10 ppm halothane). These volunteers had worse psychomotor and driving performances when measured than controls who had not been anaesthetized. No correlations were found between the concentrations of halothane or nitrous oxide in end-tidal air and psychomotor or driving performance. Despite their higher age and exposure to the operating room environment, the driving skills of the operating room nurses were similar to those of the ward nurses. The results suggest that tolerance to anaesthetic gases develops among operating room personnel. No impairment of driving skills can be expected after daily exposure to halothan and nitrous oxide among long-term employees in operating theatres.
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001334:Automobile Driving; D004781:Environmental Exposure; D006221:Halothane / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D009048:Motor Skills / Q000187:drug effects*; D009609:Nitrous Oxide / Q000009:adverse effects* / Q000032:analysis; D009873:Operating Rooms / Q000592:standards*; D013527:Perioperative Nursing; D011581:Psychological Tests
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D009609:Nitrous Oxide; D006221:Halothane