title: Controlled trial of hyposensitisation to Dermatophagoides pteronyssinus in children with asthma.
abstract: Hyposensitisation with Dermatophagoides pteronyssinus tyrosine absorbate in asthmatic children with bronchial sensitivity to D. pteronyssinus was effective in a 12-month double-blind controlled clinical trial. Compared with controls, treated children used a smaller quantity of drugs while maintaining clinical and lung function improvements. In most children who improved there was no change in immediate response to D. pteronyssinus on bronchial provocation test, but the late reaction was lost in half the patients and these showed the greatest improvement in symptoms.
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage*; D001249:Asthma / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008925:Mites; D010919:Placebos; D012129:Respiratory Function Tests; D012882:Skin Tests; D014020:Tissue Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D014443:Tyrosine / Q000627:therapeutic use
chemical_list: D000485:Allergens; D010919:Placebos; D014020:Tissue Extracts; D014443:Tyrosine