title: Interaction between vagal and chemoreceptors afferents in ventilatory response to transient hypercapnia (anaesthetized rabbit).
abstract: In rabbits anaesthetized with ethyl-carbamate, stimulation of chemoreceptors afferents was allowed by transient hypercapnia, before and after vagal blockade by DC current. In these relatively fast breathing animals, the transient hypercapnia produced light changes of inspiratory tidal volume (VI), inspiratory (TI) and expiratory durations (TE). Despite the identity of transient hypercapnia, it ensued that: (1) the higher the spontaneous VI and the lower the respiratory frequency (fR), the greater their respective changes (deltaVI and deltafR) during the ventilatory response; (2) after vagal blockade, greater changes in VI, TI, TE and mean inspiratory flow rate (VI/TI) occurred than in control state, while the relation between deltafR and fR was more significant than in control state. Respective roles played by vagal and chemoreceptors afferents in the ventilatory response to transient hypercapnia are discussed.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide; D002628:Chemoreceptor Cells / Q000503:physiopathology*; D004558:Electric Stimulation; D006935:Hypercapnia / Q000503:physiopathology*; D010100:Oxygen; D010313:Partial Pressure; D011817:Rabbits; D012119:Respiration; D013990:Tidal Volume; D014630:Vagus Nerve / Q000502:physiology* / Q000503:physiopathology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen