The effects of BCG on both cellular and humoral immunity during the early response to a hapten carrier complex.
Cell-mediated reactions to the carrier and antibody-mediated reactions to hapten and carrier were studied in guinea-pigs treated with a single i.v. injection of BCG at different intervals of time before immunization with two different doses of a hapten-carrier complex. The results clearly show that BCG-induced delayed hypersensitivity reactions to the carrier and decreased antibody synthesis to the hapten. It is proposed that BCG acts on a dispatcher cell which controls both cellular and humoral immunity.
D000707:Anaphylaxis; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D001500:BCG Vaccine; D004140:Dinitrophenols / Q000276:immunology; D006168:Guinea Pigs; D006241:Haptens; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007114:Immunization; D009163:Mycobacterium bovis; D012882:Skin Tests; D013997:Time Factors; D005719:gamma-Globulins
D001500:BCG Vaccine; D004140:Dinitrophenols; D006241:Haptens; D005719:gamma-Globulins