Functional differentiation of T cell precursors. I. Parameters of carrier-specific tolerance in murine helper T cell precursors.
Irradiated mice reconstituted with bone marrow from sheep gamma-globulin- (SGG) tolerant syngeneic donors display reduced IgG responsiveness to challenge with trinitrophenylated (TNP)-SGG compared with recipients of normal marrow. This effect is SGG-specific and is due neither to suppressor T cells nor to antigen carryover. "Helper T cell precursor tolerance" can be induced with as little as 40 micrograms tolerogen (SGG). Unlike mature helper T cells, these precursors show both a rapid induction and rapid waning patterns, suggesting a high rate of turnover. Our results imply that marrow helper T cell precursors bear antigen-specific receptors and that the T cell repertoire must be at least partially generated before residence in the thymus.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D002454:Cell Differentiation; D004306:Dose-Response Relationship, Immunologic; D007108:Immune Tolerance; D007700:Kinetics; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D012756:Sheep; D013601:T-Lymphocytes / Q000166:cytology*; D013997:Time Factors; D005719:gamma-Globulins / Q000276:immunology
D002352:Carrier Proteins; D005719:gamma-Globulins