title: [Effect of protein synthesis inhibitors on the growth and biosynthetic activity of Trichothecium roseum].
abstract: The effect of inhibitors of protein synthesis on growth was studied with Trichothecium roseum producing thichothecin and fibrinolytic enzymes. Levomycetin, acridine orange and polymyxin inhibited the biomass accumulation, the growth rate, and the biosynthesis of fibrinolytic enzymes, particularly at the early stages of fungal growth. This effect was found either when the substances were added at the same time as the mycelium was inoculated, or when they were introduced 24 hours after the beginning of cultivation. The substances inhibited the differentiation of the substrate mycelium of T. roseum. Substrate conidia, budding and initial cells were formed by the mycelium only after 72--96 hours of growth.
mesh_terms: D000165:Acridine Orange / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000494:pharmacology; D004996:Ethidium / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000096:biosynthesis*; D005419:Flavonoids / Q000494:pharmacology; D006118:Griseofulvin / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D011113:Polymyxins / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D005343:Fibrinolytic Agents; D005419:Flavonoids; D011113:Polymyxins; D006118:Griseofulvin; D002701:Chloramphenicol; D004996:Ethidium; D000165:Acridine Orange
vernacular_title: Vliianie ingibitorov belkovogo sinteza na rost i biosinteticheskuiu aktivnost' Trichlothecium roseum.