Effect of chemotherapeutic agents on the growth of rat bladder cancer, BC-47.
Effect of clinically available chemotherapeutic agents on transplantable and tissue culture bladder carcinoma cell line, BC-47, which were syngeneic to host animals, was confirmed. Adriamycin, vincristine, and bleomycin possessed predominant antitumor activity. 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) also reduced the tumor load of the host after which the tumor began to grow at the site of inoculation. Alkylating agents such as nitrogen mustard N-oxide (Nitromin), cyclophosphamide, 3,3'-dimesyloxydipropylamine tosylate (864T), and mitomycin-C possessed a weak activity, while antimetabolites such as 5-fluorouracil, 1-(1'=furyl)-5-fluorouracil (FT-207), cytosine arabinoside, and behenoylcytosine arabinoside possessed no activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002330:Carmustine / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D008937:Mitomycins / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D008937:Mitomycins; D009588:Nitrogen Mustard Compounds; D003561:Cytarabine; D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D005472:Fluorouracil; D002330:Carmustine