Mapping of the genetic control of murine response to low doses of the dinitrophenyl conjugates of ovomucoid and bovine gamma-globulin.
The antibody responses in mice to low doses of the DNP-conjugates of ovomucoid (OM) and bovine gamma-globulin (BGG) were measured for a number of inbred strains carrying independent and recombinant H-2 haplotypes. This permitted mapping the gene(s) controlling the response to low doses of OM (Ir-1-OM) within the I-A subregion of the H-2 complex. Similarly, it was possible to map the primary gene(s) controlling the response to low doses of BGG (Ir-1-BGG) within the I-A and/or I-B subregions. Further localization of the Ir-1-BGG gene(s) to the I-A or I-B subregion of the H-2 complex was not possible due to the ambiguous response of the B10.A(4R) strain of mice.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000917:Antibody Formation; D002417:Cattle; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004136:Dinitrobenzenes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004527:Egg Proteins / Q000276:immunology*; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010059:Ovomucin / Q000276:immunology*; D005719:gamma-Globulins
D000888:Antibodies, Anti-Idiotypic; D004136:Dinitrobenzenes; D004527:Egg Proteins; D006649:Histocompatibility Antigens; D005719:gamma-Globulins; D010059:Ovomucin