[Inhibition of non-cytotoxic histamine liberation from isolated rat mast cells by antihistaminic preparations].
Phenothiazines (chlorpromazine and promethazine) and antihistaminic quinuclidine derivatives [phencarol, quinuclidyl-3-di-(o-tolyl) carbinol, hydrochloride quinuclidyl-3-di-(o-methoxyphenyl) carbinol--HQMC] at concentrations preceding the histamine-releasing ones inhibited the compound 48/80-induced histamine release from the isolated rat mast cells. HQMC inhibited histamine release induced by selective liberators (compound 48/80, MCD-peptide, specific antigen), but potentiated histamine release induced by nonselective liberators (chlorpromazine, tryton X-100). The inhibition by HQMC of histamine release induced by compound 48/80 increased during 1 min and was reversible. The inhibitory effect of all the compounds tested was partially counteracted by glucose.
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D011398:Promethazine / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology*; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors*
D001559:Benzhydryl Compounds; D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D010455:Peptides; D011812:Quinuclidines; D011092:Polyethylene Glycols; D003189:p-Methoxy-N-methylphenethylamine; D011398:Promethazine; D002746:Chlorpromazine; C014742:quifenadine
Tormozhenie antigistaminnymi preparatami netsitotoksicheskogo vysvobozhdeniia gistamina iz izolirovannykh tuchnykh kletok krys.