Prevention of effects of alcohol intoxication by naloxone.
In a double-blind, cross-over study of twenty male volunteers intravenous injection of 0.4 mg naloxone prevented the impairment of psychomotor performance induced by low levels of blood alcohol. The possibility that alcohol produces intoxication by stimulating the release of endogenous opioid peptides should be investigated.
D000328:Adult; D000435:Alcoholic Intoxication / Q000517:prevention & control*; D001786:Blood Glucose / Q000032:analysis; D002986:Clinical Trials as Topic; D000431:Ethanol / Q000097:blood; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects*
D001786:Blood Glucose; D009270:Naloxone; D000431:Ethanol