title: A membrane-bound enzyme in rabbit aorta capable of inhibiting adenosine-diphosphate-induced platelet aggregation.
abstract: A membrane-bound enzyme that is capable of inhibiting adenosine-diphosphate (A.D.P.)-induced platelet aggregation has been found in rabbit aorta. This inhibition is caused by degradation of A.D.P. to products (adenosine monophosphate and adenosine) which can also inhibit aggregation. The enzyme could be important in regulating haemostasis and thrombosis.
mesh_terms: D000241:Adenosine / Q000378:metabolism / Q000494:pharmacology; D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000201:enzymology*; D001081:Apyrase / Q000494:pharmacology / Q000502:physiology*; D002457:Cell Extracts / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D002457:Cell Extracts; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D010744:Phosphoric Monoester Hydrolases; D001081:Apyrase; D000241:Adenosine