Anaphylactic reactions to muscle relaxants under general anesthesia.
Eleven patients who suffered a reaction to the administration of muscle relaxants during induction of general anesthesia were explored using skin tests, leukocyte histamine release, lymphocyte transformation test, and the Prausnitz-Küstner test (P-K). Fifteen normal subjects served as controls. Patients who suffered a reaction showed considerable cutaneous hypersensitivity to muscle relaxants. Leukocyte histamine release was positive in three cases and the P-K test was positive in one case. These findings suggest possible specific serum IgE antibodies to muscle relaxants. However, reliable discrimination between immunological and idiosyncratic pharmacological mechanism is difficult to obtain.
D000707:Anaphylaxis / Q000139:chemically induced*; D000768:Anesthesia, General; D000906:Antibodies; D005260:Female; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects
D000906:Antibodies; D009125:Muscle Relaxants, Central; D007073:Immunoglobulin E; D013390:Succinylcholine