Specificities of antibodies to acetylcholine receptors.
Antisera to acetylcholine receptor purified from the electric organs of Torpedo and Electrophorus were highly species specific, but showed limited cross-reaction with receptors from all mammalian species tested. Antisera to receptor purified from rat muscle cross-reacted extensively with receptor from the muscles of other mammals. Antibodies to receptor from Electrophorus cross-reacting with receptor from Torpedo were affinity purified. Subsequently these showed increased cross-reaction with receptor from mammalian muscle. Sera from patients with myasthenia gravis reacted best with receptor from human muscle, but such sera also cross-reacted with receptor from other mammals, especially squirrel monkeys. These sera cross-reacted slightly with receptor from Torpedo, but not detectably with receptor from Electrophorus,
D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D004557:Electric Organ / Q000276:immunology; D000939:Epitopes; D005399:Fishes; D006041:Goats / Q000276:immunology; D000882:Haplorhini; D006801:Humans; D051379:Mice; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D051381:Rats / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology*; D012453:Saimiri / Q000276:immunology; D013045:Species Specificity
D000939:Epitopes; D011950:Receptors, Cholinergic