Failure of the reaction of beta2-microglobulin with staphylococcal protein A.
Because beta2-microglobulin is structurally similar to IgG, the reaction of beta2-microglobulin with Staphylococcal Protein A, which is known to react with the Fc region of IgG, was examined. 125I-beta2-microglobulin did not bind to Protein A. This may due to the difference in the amino acid sequence between beta2-microglobulin and the Fc region of IgG.
D001609:Beta-Globulins / Q000378:metabolism*; D002846:Chromatography, Affinity; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D013205:Staphylococcal Protein A / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001609:Beta-Globulins; D007074:Immunoglobulin G; D013205:Staphylococcal Protein A; D001613:beta 2-Microglobulin