[Effects of premedication, narcosis and surgery on the coagulation and fibrinolysis systems and the platelets. The influence of dextran and hydroxyethyl starch (hes) during and after operation (author's transl)].
Patients who had undergone orthopaedic surgery were investigated. The changes attributable to premedication and narcosis were characterized by a primary fibrinolysis which was accompanied by a slight hypercoagulability. This increased fibrinolytic activity was more pronounced immediately after the beginning of the operation. The post operative changes are characterized by increased ADP-induced aggregation, increased release of platelet factors 3 and 4 and hypercoagulability with reduced fibrinolysis. The reduction in platelets during the operation could be prevented due to the influence of dextran and hydroxyethyl starch (HES). It came further to a slight increase in the activity of factor VII, to an increased fibrinogen polymerization and also to an increased release of platelet factor 4.
D000244:Adenosine Diphosphate; D000777:Anesthetics / Q000494:pharmacology*; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000209:etiology; D001792:Blood Platelets / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology*; D005169:Factor VIII; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation; D010977:Platelet Factor 3; D010978:Platelet Factor 4; D011229:Preanesthetic Medication; D013213:Starch / Q000031:analogs & derivatives*; D013514:Surgical Procedures, Operative
D000777:Anesthetics; D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D010977:Platelet Factor 3; D010978:Platelet Factor 4; D000244:Adenosine Diphosphate; D005169:Factor VIII; D013213:Starch
Durch Prämedikation, Narkose und Operation bedingte Anderungen des Gerinnungs- und Fibrinolysesystems und der Thrombozyten. Einfluss von Dextran und Hydroxyäthylstärke (HAS) während und nach Operation