Effect of pre-exposure on acute toxicity of organophosphorus insecticides to white mice.
LD50 and in vitro ChE I50 values of Chlorpyrifos, Leptophos, Phosfolan, and Stirophos against white mice showed that the formulated insecticides were higher in their mammalian toxicity than the corresponding technical materials. Pretreatment of mice with a sublethal dose of Phosfolan potentiated the toxicity of post-treatment with formulated Stirophos, Phosfolan, or Chlorpyrifos, but antagonized the toxicity of post-treatment with Leptophos. On the other hand, pretreatment with sublethal doses of Leptophos resulted in potentiation of Stirophos or Phosfolan, but decreased the toxicity of Chlorpyrifos or Leptophos. Pretreatment of mice by sublethal dose of Phosfolan synergized the in vivo inhibitory power of post-treatment by Phosfolan, Chlorpyrifos or Leptophos against brain and Plasma ChE. On the other hand pretreatment with sublethal doses of Leptophos antagonized the inhibitory power of post-treatment with either Chlorpyrifos, Leptophos or Stirophos against mice brain-ChE.
D000818:Animals; D001921:Brain / Q000201:enzymology; D004390:Chlorpyrifos / Q000633:toxicity; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000378:metabolism; D004357:Drug Synergism; D007306:Insecticides / Q000494:pharmacology / Q000633:toxicity*; D010773:Leptophos / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009946:Organothiophosphorus Compounds; D013329:Structure-Activity Relationship; D013751:Tetrachlorvinphos / Q000633:toxicity
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D010773:Leptophos; C002301:phosfolan; D013751:Tetrachlorvinphos; D002802:Cholinesterases; D004390:Chlorpyrifos