title: [Intensity renewal of skin and serum soluble proteins in rats with vitamin A deficiency].
abstract: Intensity of skin and blood serum soluble proteins renewal under conditions of vitamin A deficiency in animal organism was studied with application of the label incorporation into the electrophoretic fractions of proteins 1,3 and 24 h after administration of 14C-lysine. Metabolism of collagen proteins, amino acid composition of skin soluble proteins, content of free amino acids and nucleic acid in skin were also examined. With vitamin A deficiency the intensity of 14C-lysine incorporation into the globulin fractions of serum proteins is 2-4 times as high and into the corresponding fractions of skin proteins is 3-5 times as low as in the control. Metabolism of gamma-globulins and collagen proteins of skin under conditions of vitamin A deficiency is found to be slow. The content of DNA and RNA in skin of the avitaminous animals is reliably 17 and 23% lower, respectively. In the skin extracts obtained by means of 0.15 M NaCl the content of free amino acids with vitamin A deficiency increases. No significant changes are found in the amino acid composition of skin proteins soluble in 0.15 M NaCl, with the exception for a 20% decrease in the content of cystine together with cystein.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D003094:Collagen / Q000378:metabolism; D007700:Kinetics; D008239:Lysine / Q000378:metabolism; D009696:Nucleic Acids / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D012712:Serum Globulins / Q000096:biosynthesis; D012867:Skin / Q000378:metabolism*; D012995:Solubility; D014802:Vitamin A Deficiency / Q000378:metabolism*; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D000596:Amino Acids; D001798:Blood Proteins; D009696:Nucleic Acids; D012712:Serum Globulins; D005719:gamma-Globulins; D003094:Collagen; D008239:Lysine
vernacular_title: Intensivnist' onovlennia rozchinnikh bilkiv shkiri ta sirovatkii krovi shchuriv za nedostatnosti vitaminu a.