[Anaphylactic type of accidents due to myorelaxing agents during general anesthesia. Clinical and biological study].
Six patients who had suffered a reaction to the administration of muscle relaxants at the time of induction of general anaesthesia were explored using skin tests, the Prausnitz-Küstner reaction, the blastic transformation test, the Shelley test and the basophil histamine release test. Fifteen normal subjects were used as controls. The patients who had suffered a reaction showed considerable cutaneous hypersensitivity to muscle relaxants. None of the biological tests carried out revealed an immunological mechanism.
D000707:Anaphylaxis / Q000139:chemically induced*; D000768:Anesthesia, General / Q000009:adverse effects; D004342:Drug Hypersensitivity; D005260:Female; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D006969:Hypersensitivity, Immediate; D007073:Immunoglobulin E / Q000032:analysis; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D012871:Skin Diseases / Q000175:diagnosis; D012882:Skin Tests
D009125:Muscle Relaxants, Central; D007073:Immunoglobulin E
Accidents de type anaphylactique imputables aux myorelaxants au cours de l'anesthésie générale. Etude clinique et biologique