title: Red-blood-cell composition in thyroid disease.
abstract: Eight red-blood-cell (R.B.C.) consitituents were measured in ten patients with hyperthyroidism and in ten healthy subjects. Only R.B.C. sodium ([Na]) and zinc ([Zn]) differed much between the groups. Therefore, only these variables were measured in a larger group of untreated hyperthyroid patients. The increase in. R.B.C. [Na] and decrease in R.B.C. [Zn] were confirmed. The R.B.C. [Na] and [Zn] were related to each other and to the plasma-thyroid-hormone concentration. However, more patients had low R.B.C. [Zn] (91%) than had raised R.B.C. [Na] (50%). Further studies suggest that the R.B.C. [Zn] lags behind the clinical response when these patients are treated. These results suggest that the measurement of R.B.C. [Zn] may have a role in the diagnosis of hyperthyroidism.
mesh_terms: D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000032:analysis* / Q000201:enzymology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000628:therapy; D007037:Hypothyroidism / Q000097:blood* / Q000628:therapy; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D014284:Triiodothyronine; D012964:Sodium; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D015032:Zinc; D013974:Thyroxine; D011188:Potassium