title: Transmission of non-A non-B hepatitis to chimpanzees by factor-IX concentrates after fatal complications in patients with chronic liver disease.
abstract: 6 cases of non-A non-B hepatitis which followed administration of four different batches of concentrates of coagulation factor IX from commercial and non-commercial sources are described. Of 17 patients who received the concentrate on account of chronic liver disease, 4 developed hepatitis, and in 3 of these the illness proved fatal. The incubation periods ranged from 42 to 103 days (mean 65 days). 3 chimpanzees were inoculated with concentrate from the same batch used on the above patients, a further commercial batch upon which no adverse reactions had been reported, and plasma from a known non-A non-B carrier. All developed hepatitis after 10 weeks' incubation. Liver biopsy when serum-aminotransferase was at its highest level showed features consistent with acute hepatitis. As in the patients, viral markers for hepatitis A and B, cytomegalovirus, and Epstein-Barr virus were unchanged.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000368:Aged; D000818:Animals; D004340:Drug Contamination; D005164:Factor IX / Q000009:adverse effects*; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000209:etiology* / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000635:transmission*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D002679:Pan troglodytes; D065227:Transfusion Reaction
chemical_list: D005164:Factor IX