[Chemotherapy of skin tumors of the head and neck].
The authors report on the therapeutic results performed in the 126 skin tumors with three different chemotherapic schedules: a) Endovenous Bleomycin (BLM); b) Combined schedule with BLM, Methotrexate (MTX), Cyclophosphamide and Corticoid; c) Local BLM infiltration. There were 42,8 % of complete remission and 87,2 % of responsiveness (effectiveness). The best response rates were achieved in not advanced tumors. Local BLM infiltration has shown the best response rates 63,9 % being this schedule performed mainly in not advanced tumors. Overdosage of local infiltration may produce tissue necrose. Response rates for squamouscell carcinoma and basal cell carcinoma were alike. BMEM therapy presents the best results in the squamous cell carcinoma and the BLM infiltration in the basal cell carcinoma. There were 24 % of recurrence from the complete remissions.
D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*
D001761:Bleomycin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate
Chimiothérapie des tumeurs cutanées de la tête et du cou.