Comparative study of ascorbic acid and disodium cromoglycate in some models of experimental anaphylaxis.
The pharmacological activity of vitamin C and the antiallergic drug disodium cromoglycate are compared in models of rat mast cell degranulation and histamine release, and in protracted anaphylactic shock in the guinea pig. Our results demonstrate that ascorbic acid has a very weak inhibitory effect on degranulation and histamine release from mast cells, and therefore cannot be considered a prophylactic antiallergic drug such as disodium cromoglycate.
D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000494:pharmacology* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology*
D006633:Histamine Antagonists; D001205:Ascorbic Acid; D004205:Cromolyn Sodium