[Structural proteins of C-type RNA tumor viruses. Properties and significance for tumor immunity].
Five main structural polypeptides of Friend murine leukemia virus, a typical C-type RNA tumor virus, have been isolated. Their localization within the particle was attempted. They range from 10,000-71,000 in molecular weight and display three kinds of immunological determinants. The major envelope glycoprotein binds to cellular receptors and elicits the formation of antibodies which neutralize the virus and kill virus producing tumor cells in vitro. Natural as well as artificial immunity to this component protects mice against virus induced leukemia.
D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis; D003429:Cross Reactions; D000939:Epitopes; D005622:Friend murine leukemia virus / Q000032:analysis*; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D013045:Species Specificity; D014764:Viral Proteins / Q000032:analysis*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins
Strukturproteine von RNS-Tumorviren des C-Typs. Eigenschaften und Bedeutung für die Tumorimmunität.