Genetic control of tolerance induction to human gamma-globulin in mice.
Susceptibility to tolerance induction with monomeric human gamma-globulin (HGG) was tested in different inbred strains of mice. The results indicated a differential tolerance susceptibility among the strains and that the basis for the variation is genetic in nature. By using a protocol that permits genetic analysis, F1, F2, and backcross generations of the parental strains SJL/J and C3H/Bi were examined. A multigenic control model by H-2-linked and non-H-2-linked genes showing Mendelian autosomal inheritance is proposed.
D000818:Animals; D003433:Crosses, Genetic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D010641:Phenotype; D013045:Species Specificity; D005719:gamma-Globulins / Q000235:genetics / Q000276:immunology*
D005719:gamma-Globulins