[Morphologic and histochemical characteristics of frog skeletal muscle following application of colchicine to a motor nerve].
Experiments with application of colchicine to the muscle motor nerve carried out; this was done for the purpose of disturbance of rapid axoplasmic transport. A reduction of the areas of transverse sections of the muscle fibers, an increase in the number of fibers with a low succinic dehydrogenase (SDH) activity a greater homogeneity of the muscle fibers by the degree of optic density in staining for detection of the SDH activity was noted. Analogous changes were revealed under conditions of section of the motor nerve. However, denervation was accompanied by the block of conductivity and by degenerative changes in the nerve endings. As to the preparations treated with colchicine, transmission of excitation in the nerve and through the synapse was retained and was recorded by the end plate miniature potentials, end plate potentials and the action potentials of the muscle fibers. A conclusion was drawn that rapid axoplasmic transport brought substances maintaining differentiated state of the muscle fibers.
D000818:Animals; D001001:Anura; D001370:Axonal Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003864:Depression, Chemical; D006651:Histocytochemistry; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology / Q000294:innervation*; D013057:Spectrum Analysis; D013385:Succinate Dehydrogenase / Q000378:metabolism
D013385:Succinate Dehydrogenase; D003078:Colchicine
Morfologicheskaia i gistokhimicheskaia kharakteristika skeletnoĭ myshtsy liagushki pri applikatsii na dvigatel'nyĭ nerv kolkhitsina