[Effect of procaine on the loss of erythrocyte phospholipids during blood preservation in ACD-AG-stabilizer].
The phospholipid changes of erythrocytes were investigated following the storage under blood bank conditions up to 42 days (ACD-AG-stabilisator) without and with addition of procaine (25 mM). The phospholipid loss of erythrocytes is described as two-step occurrence. The rapid decrease in the first three days is followed by a further loss up to the end of the storage period. The concomitant increase of phospholipid fractions of supernatant shows that the erythrocyte membranes lose their phospholipids mainly by a passive way. For the further loss of phospholipids the action of a phospholipase A is adopted. The addition of procaine hinders strongly the phospholipid loss of erythrocytes. The clinical importance of these procaine action is shortly discussed.
D000143:Acids; D001793:Blood Preservation; D002951:Citrates; D004912:Erythrocytes / Q000032:analysis; D005947:Glucose; D006454:Hemoglobins; D006801:Humans; D010743:Phospholipids / Q000097:blood*; D011188:Potassium / Q000097:blood
D000143:Acids; D002951:Citrates; D006454:Hemoglobins; D010743:Phospholipids; D005947:Glucose; D011188:Potassium
Untersuchungen über die Wirkung des Procain auf den Phospholipidverlust des Erythrozyten bei der Blutkonservierung in ACD-AG-Stabilisator.