Immunoproliferation and cancer: a common macrophage-derived promoter substance.
It is suggested that a common proliferative factor is required for the growth of clones of both antigen-triggered B lymphocytes and carcinogen-triggered epithelial cells, and that the common growth-promoting substance is secreted by macrophages which have originally differentiated in support of the immune response. This macrophage-derived factor seems to be antigenically distinct from granulocyte colony-stimulating factor. Identification of the macrophage-derived clonal proliferative factor could provide new understanding of the proliferation of clones of immunocytes and neoplastic cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002999:Clone Cells / Q000473:pathology; D004815:Epidermal Growth Factor / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology
D006133:Growth Substances; D004815:Epidermal Growth Factor