title: Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles.
abstract: The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport.
mesh_terms: D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000494:pharmacology; D007210:Indoleacetic Acids / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology; D010525:Peripheral Nerves / Q000187:drug effects*; D010870:Pineal Gland / Q000032:analysis*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D007210:Indoleacetic Acids; D007211:Indoles; D009419:Nerve Tissue Proteins; D012701:Serotonin; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin; D010431:Pentoxifylline