Synthesis of alpha-fetoprotein by human yolk sac tumor transplanted into nude mice.
All nude mice bearing primary or secondary transplants of a human yolk sac tumor exhibited a high serum alpha-fetoprotein level. This finding clearly indicates the synthesis of alpha-fetoprotein by the human yolk sac tumor and supports an idea that human yolk sac tumor simulates yolk sac endoderm not only morphologically but also functionally.
D000328:Adult; D000818:Animals; D004407:Dysgerminoma / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013736:Testicular Neoplasms / Q000378:metabolism*; D014183:Transplantation, Heterologous; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins