Characterization of a type-C virus produced by co-cultures of human leukemic bone-marrow and fetal canine thymus cells.
The putative human helper virus SKA-21/A204V, isolated by Nooter et al. in 1977 from human leukemic bone-marrow cells following co-culture with normal fetal canine thymus cells, Cf2th, has been characterized with respect to its major viral core protein, reverse transcriptase, and nucleic acid sequences. The results of these analyses show that this virus is not distinguishable from the woolly monkey type-C virus, SSAV-1, by the techniques employed.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000382:microbiology*; D002460:Cell Line; D002478:Cells, Cultured; D004279:DNA, Viral / Q000276:immunology; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000382:microbiology*; D009500:Neutralization Tests; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000276:immunology; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D011863:Radioimmunoassay; D012190:Retroviridae / Q000201:enzymology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
D004279:DNA, Viral; D012367:RNA, Viral; D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase