Association between pregnancy-associated alpha2-glycoprotein (alpha2-PAG) and mixed leucocyte reaction determinants on the leucocyte surface.
alpha2-PAG is present on the surface on mononuclear blood leucocytes and can be demonstrated predominantly on B-lymphocytes and monocytes. Pretreatment of cells with antibody to alpha2-PAG leads to a marked reduction in Fc-rosette formation. Competitive blocking experiments with specific antisera reveal a particularly close association between alpha2-PAG and MLR (mixed leucocyte reaction) determinants on the cell surface. These findings suggest one mechanism whereby alpha2-PAG may modify cell-mediated immune responses.
D001402:B-Lymphocytes / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000032:analysis / Q000276:immunology* / Q000648:ultrastructure; D007959:Lymphocyte Culture Test, Mixed; D009000:Monocytes / Q000276:immunology; D011247:Pregnancy; D012397:Rosette Formation; D000511:alpha-Macroglobulins / Q000032:analysis*
D000511:alpha-Macroglobulins