Localization of blood-group A and I antigenic sites on inside-out and rightside-out human erythrocyte membrane vesicles.
Investigations of the fixation of 125I-labelled anti-A and anti-I antibodies onto rightside-out and inside-out membrane vesicles prepared from human A1 and OI erythrocytes, respectively, showed that both antibodies were bound to the rightside-out vesicles, giving clear evidence that blood group A and I antigenic sites are exclusively localized on the external surface of the membrane.
D000017:ABO Blood-Group System; D001666:Binding Sites, Antibody; D001789:Blood Group Antigens; D000939:Epitopes; D004910:Erythrocyte Membrane / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007048:I Blood-Group System
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D000939:Epitopes; D007048:I Blood-Group System