Is non-specific cross-reacting antigen a marker on the surface of human basophils?
Leucocytes challenged with anti-NCA serum (non-specific cross-reacting antigen) can release histamine. This release is Ca++, glucose and temperature dependent as usually described for basophils. Only half of the subjects whose basophils can release histamine when challenged with anti-IgE serum are also able to release histamine with anti-NCA serum. There is no cross-reaction between IgE and anti-NCA serum or between NCA and anti-IgE serum. So it seems likely that NCA might be a marker on the surface of some human basophils.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis*; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D002272:Carcinoembryonic Antigen; D002462:Cell Membrane / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E; D008297:Male; D008875:Middle Aged
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D002272:Carcinoembryonic Antigen; D007073:Immunoglobulin E