Liver damage from long-term methyltestosterone.
Of 60 patients (42 female transsexuals and 18 impotent males) receiving long-term therapy with methyltestosterone 50 mg three times a day, 19 had abnormal liver-function tests and 33 out of 52 had abnormal liver scans, particularly those who had been treated for more than a year. Liver biopsy specimens showed accumulation of hepatocytes in the liver cords and within the walls of centrilobular veins, and early peliosis hepatis. One patient had a hepatic adenoma. Of the androgens, only 17alpha-alkylated steroids seem to be implicated in the development of cholestatic jaundice, peliosis hepatis, and liver tumours.
D000236:Adenoma / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008777:Methyltestosterone / Q000009:adverse effects* / Q000627:therapeutic use; D011693:Purpura / Q000139:chemically induced* / Q000175:diagnosis; D014189:Transsexualism / Q000188:drug therapy
D008777:Methyltestosterone