[The effect of the AcD-AG stabilizer on the survival time and surface properties of fluid preserved platelet concentrates compared to concentrates from fresh blood].
In the present investigations the storage effect the AcD-AG stabilizer on thrombocytes is examined. The thrombocytokinetic parameters of 9 fresh blood concentrates and 15 concentrates of AcD-AG plasma containing platelets were determined. Storage time amounted to three days. The results show that storage with AcD-AG is only possible to a limited degree. On an average the survival time of the platelets was reduced to 2.7 +/- 1.1 days compared with 9.0 +/- 1.0 days of fresh blood concentrates. The recovery of the stored platelets amounted to 25.3 +/- 16.1%, that of the fresh blood concentrates to 63.3 +/- 23.6%. The spleen-heart quotients and those of the liver-heart or the surplus impulses over the spleen and liver respectively indicate that there is a predominant destruction in the spleen for those thrombocytes stored for three days. The liver is scarcely involved in this sequestration process. With 36.1% platelet yield was very low in concentrates gained from AcD-AG plasma containing platelets and having been stored for 3 days. In cases of emergency a clinical application of concentrates prepared in this way should not be given up. If being used, the greater requirement has to be taken into account. If the substitution therapy is continued, however, fresh blood concentrates have to be used as soon as possible.
D000225:Adenine / Q000494:pharmacology; D001792:Blood Platelets; D001793:Blood Preservation; D001803:Blood Transfusion; D002470:Cell Survival / Q000187:drug effects; D002951:Citrates / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006151:Guanosine / Q000494:pharmacology; D006801:Humans; D013499:Surface Properties
D002951:Citrates; D006151:Guanosine; D005947:Glucose; D000225:Adenine
Der Einfluss von AcD-AG-Stabilisator auf die Uberlebenszeit und Oberflächenaktivität von flüssigkeitskonservierten Plättchenkonzentraten im Vergleich zu Konzentraten aus Frischblut.