[Antibodies in gamma-globulin preparations (author's transl)].
A commerical preparation of gamma-globulin with 16% protein content for i. m. administration, as well as two commercial preparations of 5% protein content for i.v. administration, were tested for their antibodies to different viruses. The highest antibody titres were found in the 16% gamma-globulin. Sufficient levels of antibodies to justify prophylactic use were demonstrated in the case of rubella, measles, polio and EBV, whilst antibodies to mumps, coxsackie A9, B1-5 and herpes simplex type I and II were present to a moderate degree. Only low concentrations of antibodies or none at all were found with respect to influence A and B, para-influenza 1--3, vaccinia, adeno 3 and 7, and echo 4, 6, 9, 18 and HBs-antigen. This study shows that normal gamma-globulin can be used prohylactically against many different viral diseases.
D000914:Antibodies, Viral / Q000302:isolation & purification*; D000917:Antibody Formation; D003384:Coxsackievirus Infections / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006385:Hemagglutination Inhibition Tests; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D009107:Mumps / Q000276:immunology; D009500:Neutralization Tests; D012409:Rubella / Q000276:immunology; D005719:gamma-Globulins / Q000032:analysis*
D000914:Antibodies, Viral; D005719:gamma-Globulins
Der Gehalt an Antikörpern gegen Viren in einigen Gammaglobulinpräparaten