Inductive influence of macrophages on cytotoxic properties of lymphocytes.
Normal rat lymphocytes preincubated over syngeneic peritoneal macrophages derived from rats sensitized to tuberculous bacilli and then cultured with PPD showed a cytotoxic effect on sheep red blood cells coated with PPD. This effect was antigen specific and did not involve the nonspecific influence of macrophages.
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D014373:Tuberculin
D000939:Epitopes; D014373:Tuberculin