[State and development of liquid conservation of thrombocytes].
In the present investigation the storage effect of AcD-AG and CPD-AG-stabilizers on thrombocytes was tested. The platelets were stored in platelet-rich plasma (PRP) at 4 degrees C or room temperature for 3 days. The concentrates gained by it were marked with Na251CrO4 and reinjected. The thrombocytokinetic parameters were evaluated. The results show that storage with the help of the mentioned stabilizers can be made to a certain extent only. Platelets stored in AcD-AG stabilizerhad a survival time of 2.7 +/- 1.1 days towards 9.0 +/- 1.0 days of fresh whole blood concentrates. The survival time of CPD-AG thrombocytes stored at 4 degrees C for 3 days amounted to 2.0 +/- 0.5 days. Storage of CPD-AG platelets at room temperature showed favourable results. Their survival time amounted to 6.2 +/- 0.6 days. Measurements of surface activity above the spleen and the liver indicate that degradation of stored platelets is mainly performed in the spleen. Problems of liquids storing in view of the significance of therapeutic thrombocyte substitution for hospitals are referred to.
D001772:Blood Cell Count; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D001793:Blood Preservation / Q000379:methods*; D002470:Cell Survival; D006801:Humans; D008099:Liver / Q000378:metabolism; D010949:Plasma; D013154:Spleen / Q000378:metabolism; D013696:Temperature
Stand und Entwicklung der Flüssigkonservierung von Thrombozyten.