B-cell alloantigen associated with chronic mesangiocapillary glomerulonephritis.
Thirteen patients with chronic mesangiocapillary glomerulonephritis (M.C.G.) defined by light and immunofluorescent microscopy were examined for possible B-lymphocyte alloantigen associations by means of antisera from multiparous mothers of M.C.G. probands. Three such sera reacted with M.C.G.-patient B-cells. One of these sera (M.C.G.3) was highly discriminative for a B-cell antigen present in 77% of M.C.G. patients and only 17% of normal individuals tested. The risk of developing M.C.G. was estimated to be 16-6 times greater in the presence of the M.C.G.3 antigen than in its absence. This is the first demonstration of an association between a specific B-lymphocyte determinant and immune-mediated glomerulonephritis.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D002908:Chronic Disease; D000939:Epitopes; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007106:Immune Sera; D007519:Isoantigens / Q000302:isolation & purification*; D010298:Parity; D007690:Polycystic Kidney Diseases / Q000276:immunology; D012306:Risk
D000939:Epitopes; D007106:Immune Sera; D007519:Isoantigens