[beta2-Microglobulin in renal transplanted patients (author's transl)].
Plasma beta2m has been measured frequently during long term follow-up of kidney transplanted outpatients. The ratio of beta2m/log creatinine was abnormally high in 15 patients of this series bearing a symptomatic hepatitis independently of any modification of immunodepressive drug administration schedule (azathioprine and corticoids). The true effect of azathioprine could not be isolated whereas corticotherapy modified clearly the beta2m/creatinine ratio : increase of dosage for rejection resulted in a fall of the ratio whereas fast reduction increased the ratio acting essentially on circulating beta2m level (12 cases). The beta2m/creatinine ratio was normal or occasionally diminished in the 22 patients having an uneventful clinical course. Six patients showed mixed effects of hepatitis and variation of corticoid dosage and 7 cases were too much intricated to permit a good analysis of the data.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D001379:Azathioprine / Q000494:pharmacology; D001609:Beta-Globulins / Q000032:analysis*; D003404:Creatinine / Q000097:blood; D003864:Depression, Chemical; D005500:Follow-Up Studies; D006505:Hepatitis / Q000503:physiopathology; D006801:Humans; D016030:Kidney Transplantation; D001613:beta 2-Microglobulin / Q000032:analysis* / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D001609:Beta-Globulins; D001613:beta 2-Microglobulin; D003404:Creatinine; D001379:Azathioprine
La beta2-microglobuline plasmatique chez les transplantés rénaux.