Cell-mediated cytotoxic response to cells bearing Marek's disease tumor-associated surface antigen in chickens infected with Marek's disease virus.
In a microcytotoxicity test in which 51Cr-labeled cells of a Marek's disease (MD) lymphoblastoid line (MSB-1 line) were used, cell-mediated cytotoxicity of spleen cell suspensions prepared from chickens inoculated with MD virus was demonstrated. This cytotoxic response, presumably directed against MD tumor-associated surface antigen, was detectable briefly after virus infection and paralleled the appearance of early lymphoproliferative lesions characteristic of MD.
D000818:Animals; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002645:Chickens; D002860:Chromium Radioisotopes; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D008381:Herpesvirus 2, Gallid / Q000276:immunology*; D007111:Immunity, Cellular; D008380:Marek Disease / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D002860:Chromium Radioisotopes; D000939:Epitopes