T-lymphoblastoid cell lines from Marek's disease lymphomas.
The establishment and continuous culture of two lymphoblastoid cell lines derived from Marek's disease lymphomas is described. Although the cells carried T-lymphocyte surface antigens, they had many features in common with cultured Burkitt's lymphoma lymphoblasts, which carry B-cell determinants. A small proportion acted as infectious units in tissue culture, and a similarly small proportion contained intranuclear immature herpesvirus particles. The cells did not respond to phytohaemagglutinin. One cell line possessed some graft-versus-host capacity, as measured by the induction of splenomegaly. It is concluded that the development of acute Marek's disease involves the malignant transformation of thymus-dependent lymphocytes by Marek's disease virus.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002455:Cell Division; D002460:Cell Line; D002642:Chick Embryo; D002645:Chickens; D000939:Epitopes; D005260:Female; D008381:Herpesvirus 2, Gallid / Q000276:immunology; D007181:Inclusion Bodies, Viral; D037102:Lectins / Q000494:pharmacology; D008223:Lymphoma; D008380:Marek Disease; D010051:Ovarian Neoplasms; D013163:Splenomegaly / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology / Q000648:ultrastructure
D000956:Antigens, Viral; D000939:Epitopes; D037102:Lectins