Liberation of histamine by compound 48/80, tolazoline, betahistine and burimamide from isolated spontaneously beating guinea pig and rabbit atrial pairs.
Tolazoline, betahistine, burimamide and compound 48/80 release histamine from isolated guinea pig atria resulting in histamine concentrations that stimulate H2-receptors. Tolazoline, burimamide and 48/80 also release histamine from rabbit atria but do not result in histamine concentrations that will stimulate either H1- or H2-receptors. However, betahistine (which does not release histamine from rabbit atria) and tolazoline stimulate the rabbit atrial chronotropic response by releasing catecholamines.
D000818:Animals; D001621:Betahistine / Q000494:pharmacology*; D002049:Burimamide / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D013045:Species Specificity; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors; D014043:Tolazoline / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D011725:Pyridines; D003189:p-Methoxy-N-methylphenethylamine; D014043:Tolazoline; D013890:Thiourea; D002049:Burimamide; D001621:Betahistine