[Composition and properties of immunoglobulin G in cattle with lymphatic leukemia].
The data are presented concerning the qualitative changes in cattle immunoglobulin G with lymphoid leukosis. Protein peculiar to cattle leucosis is shown to be an immunoglobulin G subfraction which is washed out of the DEAE-cellulose column by 0.1 M of NaCl. Its molecular mass is 130,000 Daltons. The data of immunoelectrophoresis and ultracentrifugation show that it is homogeneous. The protein sedimentation constant is 7.2 S. The electrophoretic mobility is 0.18-0.19 of bull albumin mobility. The amino acid analysis of this protein shows that the content of methionine in it is more than 20% lower. This evidences for its similarity to protein characteristic of myeloma and Shvets leukosis in rats. This manifests similarly of proteins peculiar to different forms of malignant growth. This protein has common antigenic determinants with the protein peculiar to human malignant growth.
D000596:Amino Acids; D000818:Animals; D000951:Antigens, Neoplasm; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D000939:Epitopes; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D007942:Leukemia, Experimental; D007945:Leukemia, Lymphoid / Q000276:immunology*; D009363:Neoplasm Proteins / Q000032:analysis
D000596:Amino Acids; D000951:Antigens, Neoplasm; D000939:Epitopes; D007074:Immunoglobulin G; D009363:Neoplasm Proteins
Sostav i svoĭstva immunoglobulina G krupnogo rogatogo skota pri limfoleĭkoze.