Effects of hexachlorocyclohexane isomers on concanavalin A 'capping' in bovine lymphocytes.
The effects of alpha, beta, gamma, and delta isomers of hexachlorocyclohexane on concanavalin A 'capping' in bovine lymphocytes were evaluated, gamma and delta hexochlorocyclohexane inhibited 'capping' whereas the alpha and beta isomers were without effect. In addition, gamma-hexachlorocyclohexane has been shown to antagonize the maintenance of preformed 'caps' and cause the rapid dispersal of the concanavalin A-receptor complexes over the surface of cells by a temperature-dependent mechanism. The possible role of a gamma-hexachlorocyclohexane-sensitive process in the organization of microflow patterns in the lectin-activated lymphocyte membrane is discussed.
D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology*; D003567:Cytidine Diphosphate Diglycerides / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007152:Immunologic Capping / Q000187:drug effects*; D007294:Inositol / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D013237:Stereoisomerism
D003567:Cytidine Diphosphate Diglycerides; D003208:Concanavalin A; D007294:Inositol; D001556:Hexachlorocyclohexane