[The effect of oral contraceptives on levels of thyroid hormone, blood coagulation and ceruloplasmin (author's transl)].
The effect of various hormonal contraceptives on the thyroid hormone level, plasmatic and thrombocytic coagulation, cholesterol and ceruloplasmin levels and the activity of gamma-glutamyl transpeptidase was investigaged by the changes produced by long term cyclic estrogen-gestagen therapy on the metabolism of the organism. The free thyroxine index and the total cholesterol were within the normal range. The thyroxine binding index at 44% was above the normal level and the mean value was significantly raised. The ceruloplasmin concentration in the serum was also significantly increased. Pointers to a general hypercoagulability could not be ascertained with a statistical significance.
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D002570:Ceruloplasmin / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005165:Factor V; D005170:Factor X; D005260:Female; D005340:Fibrinogen; D006801:Humans; D008656:Mestranol / Q000494:pharmacology; D008875:Middle Aged; D011372:Progestins / Q000494:pharmacology; D011516:Prothrombin; D013916:Thrombelastography; D013925:Thromboplastin; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood*
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D011372:Progestins; D004997:Ethinyl Estradiol; D005165:Factor V; D011516:Prothrombin; D005170:Factor X; D005340:Fibrinogen; D013925:Thromboplastin; D002784:Cholesterol; D008656:Mestranol; D002570:Ceruloplasmin; D013974:Thyroxine
Beeinflussung von Schilddrüsen-hormonspiegel, Blutgerinnung und Zöruloplasmin durch Ovulationshemmer.