The patas monkey as a model for dihydrostreptomycin ototoxicity.
Although the cochlear toxicity of dihydrostreptomycin (DHSM) is well-recognized in man, it has always proved difficult to demonstrate in animals. Hearing thresholds in M. nemestrina monkeys remained essentially unchanged after DHSM 100 mg/kg im daily for 8 months, but E. patas monkeys were severely deafened by DHSM 20 mg/kg for 90 days, a regimen formerly used in treating human tuberculosis. The patas monkey may prove to be the animal model of choice for evaluating aminoglycoside ototoxicity.
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D003638:Deafness / Q000139:chemically induced*; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004901:Erythrocebus patas; D000882:Haplorhini; D007273:Injections, Intramuscular; D008251:Macaca; D008252:Macaca fascicularis; D009925:Organ of Corti / Q000187:drug effects; D013997:Time Factors; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects
D004096:Dihydrostreptomycin Sulfate