Effect of furosemide on the urinary excretion of some plasma proteins.
In 30 patients with a variety of glomerular renal disorders, intravenously administered furosemide was associated with a significant increase of the urinary excretion of the protein fraction with a molecular weight higher than 50,000. The excretion of protein with a molecular weight less than 50,000 was not altered. In relation to endogenous clearance of creatinine the clearance of transferrin, IgG and alpha2-macroglobulin increased significantly. In relation to transferrin clearance, the clearance values of albumin and IgG remained unchanged, whereas that of alpha2-macroglobulin increased significantly. These results support the view that furosemide increases the permeability of the glomerular capillary for serum proteins.
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007674:Kidney Diseases / Q000652:urine; D007678:Kidney Glomerulus / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011507:Proteinuria; D014168:Transferrin / Q000652:urine; D000511:alpha-Macroglobulins / Q000652:urine
D001798:Blood Proteins; D014168:Transferrin; D000511:alpha-Macroglobulins; D005665:Furosemide