The effect of endotoxin on the mast cell c'AMP system.
To determine whether the endotoxin induced release of histamine is mediated via the mast cell c'AMP system, hamster mast cells were isolated and incubated (prior to endotoxin-serum stimulates (ET-S) with disodium cromoglycate, isoproterenol and aminophylline. All drugs caused significant inhibition of the ET-S histamine release. The authors conclude that ET-S utilizes the c'AMP system to release histamine.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D006224:Cricetinae; D004205:Cromolyn Sodium; D000242:Cyclic AMP / Q000378:metabolism*; D004731:Endotoxins / Q000494:pharmacology*; D006636:Histamine Release; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008407:Mast Cells / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology
D004731:Endotoxins; D000628:Aminophylline; D001285:Atropine; D000242:Cyclic AMP; D007545:Isoproterenol; D004205:Cromolyn Sodium; D010646:Phentolamine