Pseudomembranous colitis: Presence of clostridial toxin.
A toxin was found in the faeces of nine out of nine patients with pseudomembranous colitis and two out of two with antibiotic-associated non-specific colitis. The toxin was neutralised by Clostridium sordellii antitoxin but not by a commercial mixture of C. welchii, oedematiens, and septicum antitoxins. The in-vitro and in-vivo properties of pseudomembranous-colitis toxin closely resemble those of the toxin of C. sordellii.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000992:Antitoxins / Q000494:pharmacology; D001427:Bacterial Toxins / Q000032:analysis / Q000302:isolation & purification / Q000633:toxicity; D001681:Biological Assay; D003013:Clostridium; D046508:Culture Techniques; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology* / Q000382:microbiology; D005243:Feces / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000992:Antitoxins; D001427:Bacterial Toxins