title: Plasma assay of fetal factors VIIIC and IX for prenatal diagnosis of haemophilia.
abstract: Fetal blood unmixed with maternal blood or amniotic fluid was obtained by direct-vision fetoscopy in 22 consecutive cases at 15--22 weeks' gestation; the investigation was done either for prenatal diagnosis or before therapeutic abortion. Fetal plasma factors VIIIC and IX averaged 50 I.U./dl (S.D. 12.8) and 12.5 I.U./dl (S.D. 2.4), respectively. Two male fetuses at risk of haemophilia had normal factor VIIIC levels by these criteria, and both pregnancies ended in the birth of a normal boy. Five others gave 3 normal and 2 haemophilic results, which were confirmed in two of the three terminated pregnancies.
mesh_terms: D000649:Amniocentesis / Q000379:methods; D001780:Blood Coagulation Tests / Q000379:methods; D005164:Factor IX / Q000032:analysis*; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D020669:Fetoscopes; D005865:Gestational Age; D006467:Hemophilia A / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012737:Sex Factors
chemical_list: D005169:Factor VIII; D005164:Factor IX