[The effect of exogenous alkalization on cytokinetics and on the survival rate of mice with lymphoblastic leukemia].
In mice vaccinated with two forms of lymphoblastic leukaemia and alkalized with intravenous administration of sodium bicarbonate, the survival rate, the extent of leukaemic infiltration and the proliferative capacity of cells in the bone-marrow, thymus, spleen, lymphnodes, liver and lungs were investigated. The survival rate in the TAL leukaemia of the AKR stem producing an endogenous acidosis could be significantly prolonged in a statistical way by alkalization. Yet an accelerated expiring rate could be observed after exogenous alkalization in L-1210 leukaemia of the DBA/2J stem producing an endogenous alkalosis. By means of cytological and impulse-cytophotometrical investigations the exogenous alkalization of both forms of leukaemia could be proved to have a direct bearing on the proliferative kinetics. In TAL leukaemia the leukaemic proliferation was inhibited by the exogenously involved correction of the acid-base balance; in the L-1210 leukaemia, however, the pH disturbances were enhanced, thus accelerating the leukaemic proliferation. Consequently, the disturbances of the acid base balance seem to be an essential cofactor in the leukaemia genesis. The exogenous direction of the acid-base balance may be important as a means of treating leukaemia.
D000818:Animals; D001639:Bicarbonates / Q000009:adverse effects*; D001854:Bone Marrow Cells; D002455:Cell Division; D006863:Hydrogen-Ion Concentration; D007942:Leukemia, Experimental / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
D001639:Bicarbonates
Der Einfluss exogener Alkalisierung auf zytokinetische Vorgänge und die Uberlebensrate von Mäusen mit lymphoblastischer Leukämie