Enhancement of human kidney allografts by cold B-lymphocyte cytotoxins.
The sera of 233 kidney transplant patients before transplantation were tested by cytotoxicity against a panel of B and T lymphocytes at 5 degrees C and 37 degrees C. The results divided the patients into four groups: those whose sera reacted with B lymphocytes at 5 degrees C; those reacting with B lymphocytes at 5 degrees C and 37 degrees C; those reacting with T lymphocytes at 37 degrees C; and those with no antibodies. The patients with pre-transplant antibodies reactive with B lymphocytes at 5 degrees C had a significantly higher kidney-transplant survival rate at 6 months (70%) and 1 year (65%) than patients who had no antibodies (47% and 46%, respectively). Patients with antibodies reactive at 37 degrees C had a 6-month survival-rate of 38% when reactive against B cells and 43% when reactive against T lymphocytes. The cold cytotoxins were IgM.
D001402:B-Lymphocytes / Q000276:immunology; D003080:Cold Temperature; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007075:Immunoglobulin M / Q000302:isolation & purification*; D066298:In Vitro Techniques; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D008233:Lymphotoxin-alpha / Q000302:isolation & purification*; D008297:Male; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous
D007075:Immunoglobulin M; D008233:Lymphotoxin-alpha