Effect of bleomycin on cell survival and some implications for tumor therapy.
Tumor is normally composed of cells growing and non-growing and, therefore, of cells having different responses to exogenous agents. Hence, it is not possible to treat a tumor with an unitary principle. As far as the tumor cell sterilization by bleomycin is concerned, the growing fraction of tumor should be managed by fractional schedule, while plateau phase cells by continuous infusion. Based on the cell sterilization kinetics, further improvement of chemotherapy by bleomycin must be sought. The investigation will duly involve the studies on the nature of resistance induction and PLD repair.
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D066298:In Vitro Techniques; D007700:Kinetics; D007739:L Cells / Q000187:drug effects; D009994:Osmolar Concentration; D013997:Time Factors
D001761:Bleomycin