title: Effect of heptabarbital on bioavailability of bishydroxycoumarin in the rat.
abstract: The influence of oral administration of heptabarbital on the gastrointestinal absorption of bishydroxycoumarin (BHC) was investigated in rats. Pretreatment of the animals with 20 mg/kg heptabarbital twice dialy for three days prior to the administration of 50 mg/kg BHC resulted in a 40% decrease from controls in the area under the BHC plasma concentration time curve (AUC). Preliminary studies indicated that a similar decrease in gastrointestinal absorption of BHC could be seen following a single oral dose of heptabarbital administered concomitantly with the anticoagulant.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001682:Biological Availability; D001728:Dicumarol / Q000008:administration & dosage / Q000378:metabolism*; D004347:Drug Interactions; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D051381:Rats
chemical_list: D001463:Barbiturates; D001728:Dicumarol