title: [Antithyroid activity of various newly synthesized 1,3-thiazine derivatives].
abstract: Experiments were performed on rats. It was revealed that three newly-synthesized 1,3-thiazine derivative (1,3-thiazandithion-2,4, 1,3-thiazanthion-2-on-4-thiosemicarbazone-4, and 1,3-thiazandion-2,4) possessed and antithyroidal action in doses equal to 15% of LD50; in the two former preparations it was accompanied by an goiterogenic effect. 1,3-thiazandion-2,4 had the most antithyroidal action and relatively weak goiterogenic effect.
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D008297:Male; D011134:Polysaccharides / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013843:Thiazines / Q000494:pharmacology*; D013871:Thiones / Q000494:pharmacology; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D013956:Antithyroid Agents; D011134:Polysaccharides; D013843:Thiazines; D013871:Thiones; D012313:RNA; D001205:Ascorbic Acid
vernacular_title: Ob antitireoidnoĭ aktivnosti nekotorykh vnov' sintezirovannykh proizvodnykh 1,3-tiazana.