Suppression of serum thyrotropin (TSH) concentrations following thyroidectomy and cold exposure by passive immunization with antiserum to thyrotropin-releasing hormone (TRH) in rats.
Administration of antiserum to synthetic thyrotropin-releasing hormone (TRH) to thyroidectomized rats caused a significant depression of serum thyrotropin (TSH). Serum TSH and triiodothyronine (T3) responses to cold exposure (4 +/- 1 C) were abolished by administration of anti-TRH serum. In addition, synthetic TRH lost its biological activity when bound to the gamma globulin fraction from the anti-TRH serum. These observations provide evidence that TRH is involved in the mechanism of enhanced TSH secretion from the pituitary following thyroidectomy and cold exposure.
D000818:Animals; D003080:Cold Temperature; D007106:Immune Sera / Q000494:pharmacology; D007112:Immunity, Maternally-Acquired; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D051381:Rats; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood* / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000276:immunology*; D014284:Triiodothyronine / Q000097:blood; D005719:gamma-Globulins / Q000494:pharmacology
D007106:Immune Sera; D005719:gamma-Globulins; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin