Hematologic and serologic studies in 6-sulfanilamidoindazole arthritis.
6-sulfanilamidoindazole (6-SAI), an antibacterial sulfonamide, is known to cause an acute, self-limited inflammatory reaction in the hind paws of older rats. Administration of 6-SAI results in hyperfibrinogenemia which precedes the onset of clinical arthritis. The hyperfibrinogenemia is associated with the prolongation of dilute blood clot lysis times, appearance of heparin-precipitable fibrinogen, elevations in fibrin degradation products, and complement titers and serum electrophoretic pattern changes that consist of decreased albumin concentrations and increased beta globulin concentrations. Alterations in 6-SAI medicated young rats are less marked and require higher doses.
D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D001168:Arthritis / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control; D001609:Beta-Globulins / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006614:Hindlimb; D007016:Hypophysectomy; D007279:Injections, Subcutaneous; D007501:Iron / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011485:Protein Binding; D051381:Rats; D012709:Serum Albumin / Q000032:analysis; D013424:Sulfanilamides / Q000008:administration & dosage / Q000097:blood
D001609:Beta-Globulins; D005338:Fibrin Fibrinogen Degradation Products; D012709:Serum Albumin; D013424:Sulfanilamides; D005340:Fibrinogen; D003165:Complement System Proteins; D007501:Iron; D008775:Methylprednisolone