Fibrinolytic factors in aqueous humour and serum from patients with Fuchs' dystrophy and patients with cataract.
The concentration of alpha 2-macroglobulin, alpha 1-antitrypsin, plasminogen, C3-complement, fibrinogen degradation products (FDP) and fibrinolytic activity, were studied in the aqueous humour and serum from nine patients with Fuchs' endothelial dystrophy, 17 patients with uncomplicated senile cataract and in the secondary aqueous from six cataract patients. Finally, the aqueous humour and serum from two patients anterior uveitis were studied. An increased concentration of alpha 2-macroglobulin, alpha 1-antitrypsin, plasminogen and C3-complement was found in both the aqueous and the serum from patients with Fuchs' dystrophy when compared with the primary aqueous and serum from patients with cataract but this was only significant for alpha 1-antitrypsin in aqueous humour. A significant increase in the amount of FDP was found in the serum of the Fuchs' patients compared with the cataract patients. Fibrinolytic activity could not be demonstrated in the serum in any of the patient groups. The concentrations of the various factors found in the secondary aqueous of the cataract patients differed only slightly from the content of the primary aqueous of the Fuchs' patients.
D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D002386:Cataract / Q000097:blood / Q000378:metabolism*; D003176:Complement C3 / Q000378:metabolism; D003317:Corneal Dystrophies, Hereditary / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000097:blood / Q000378:metabolism*; D005642:Fuchs' Endothelial Dystrophy / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010958:Plasminogen / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D003176:Complement C3; D005338:Fibrin Fibrinogen Degradation Products; D005343:Fibrinolytic Agents; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010958:Plasminogen