[Mechanism of action of synthetic heparinoids: results in patients with hypertriglyceridaemia (author's transl)].
The effect of two synthetic heparinoids, SP-54 and Depot-Thrombocid, on serum lipids was studied in 17 patients with primary hyperlipidaemia (types IIb, IV and V of Fredrickson) and 15 healthy persons. SP-54 had no lipid-lowering effect, neither on oral nor rectal suppository application. Intramuscular injection of Depot-Thrombocid, however, resulted in a decrease of serum triglyceride concentrations of maximally 50% after six hours. There was a marked increase in the activity of the two lipolytic enzymes, lipoprotein lipase and hepatic triglyceride lipase in plasma, as well as an increase in free fatty acids and an extension of thrombin time and PTT. Twenty-four hours after injection all values returned to pretreatment levels. Intramuscular administration of Depot-Thrombocid two or three times a week for seven weeks had no lasting effect on serum lipids. However, there were considerable side effects such as haemorrhagic diatheses, hair loss and thrombocytopenia.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000505:Alopecia / Q000139:chemically induced; D001780:Blood Coagulation Tests; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006474:Hemorrhagic Disorders / Q000139:chemically induced; D006496:Heparinoids / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D005230:Fatty Acids, Nonesterified; D006496:Heparinoids; D014280:Triglycerides
Der Wirkungsmechanismus synthetischer Heparinoide. Resultate bei Patienten mit Hypertriglyceridämie.