The correlation of bacteriophage types of Mycobacterium tuberculosis with guinea-pig virulence and in vitro-indicators of virulence.
Among 58 isoniazid-sensitive strains of Mycobacterium tuberculosis from India, Burma and East Africa, 23 were of phage type A, 31 of type I (intermediate), 4 of type B and none of type C. Type I strains differed from type A strains in being attenuated in the guinea-pig, susceptible to H2O2, sensitive to thiophen-2-carboxylic acid hydrazide and resistant to thiacetazone and p-aminosalicylic acid; the content of strongly acidic lipids and of sulphatide lipids was low and the attenuation indicator lipid was present. The pattern of results with the type B strains did not correspond to the patterns for types A or I. Strains of type I appear to be a distinct group within the species M. tuberculosis.
D010131:Aminosalicylic Acid / Q000494:pharmacology; D000818:Animals; D001434:Bacteriophage Typing; D006168:Guinea Pigs; D006834:Hydrazines / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008055:Lipids / Q000032:analysis; D009160:Mycobacteriophages; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000472:pathogenicity*; D013828:Thioacetazone / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology
D006834:Hydrazines; D008055:Lipids; D013876:Thiophenes; D010131:Aminosalicylic Acid; D006861:Hydrogen Peroxide; D013828:Thioacetazone