title: [Blocking of the reaction of the pituitary gland to exogenic thyroxine after its administration together with an antithyroid agent].
abstract: It was experimentally revealed that 1-thyroxin administered in combination with an antithyroid preparation caused no depression of the thyrotropic function of the hypophysis whose activation was caused by the inhibitory action of the antithyroid agent on the thyroid gland. At the same time combined administration of the preparations failed to lead to the thyroxin inactivation. The "block effect" of the hypophysis response to the thyroxin administration persisted even with such low doses of antithyroid preparation which failed to depress the thyroid function, and, correspondingly, did not activate the thyrotropic hormone production by the hypophysis.
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003864:Depression, Chemical; D004336:Drug Antagonism; D005260:Female; D010902:Pituitary Gland / Q000187:drug effects*; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D013956:Antithyroid Agents; D013974:Thyroxine
vernacular_title: Blokada gipofiza na ekzogennyĭ tiroksin pri sovmestnom vvedenii poslednego s antitireoidnym agentom.