Studies on the characteristics of poliovirus type 3. II. Characteristics of "hot" clones.
Markers d, IST, EA1(OH)3, rct (at sub- and supraoptimal temperatures) and neurovirulence were determined for clones isolated from two lots (S2 and S3) of vaccines containing poliovirus strain Leon 12a1b. Changes of markers rct, d and neurovirulence were observed in several clones isolated from S2 vaccine. No changes were observed in IST and EA1(OH)3 markers.
D000818:Animals; D001921:Brain / Q000382:microbiology; D002521:Cercopithecus; D000939:Epitopes; D005796:Genes; D000882:Haplorhini; D017955:Poliovirus / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity; D011054:Poliovirus Vaccine, Inactivated; D013116:Spinal Cord / Q000382:microbiology; D013696:Temperature; D014774:Virulence; D014779:Virus Replication
D000939:Epitopes; D011054:Poliovirus Vaccine, Inactivated