title: The identification of individuals at high risk for large bowel cancer and the application of preventive measures in their management: chromosome studies in Gardner syndrome and familial polyposis.
abstract: The significance of chromosomal markers in linkage and assignment has been pointed out. The usefulness of linkage in disease prevention is discussed with the limitations of this approach.
mesh_terms: D002875:Chromosomes / Q000648:ultrastructure; D002877:Chromosomes, Human; D003110:Colonic Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D011110:Polymorphism, Genetic; D011127:Polyps / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics*; D013194:Staining and Labeling