The interaction of short-chain aralkyl alcohols and amines with the erythrocyte membrane.
Erythrocytes in isotonic saline are hemolyzed by benzyl alcohol and by 2-phenylethanol, but not by the corresponding amines nor by the ring-or side-chain-hydroxylated analogs. All these compounds could however interact with the erythrocyte membrane since: a) they facilitated the hemolytic effect of benzyl alcohol and/or of phenylelytic effect of benzyl alcohol and/or of phenylethanol; b) they exerted a protective effect against controlled hypotonic hemolysis.
D000438:Alcohols / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001592:Benzyl Alcohols / Q000494:pharmacology; D002417:Cattle; D002463:Cell Membrane Permeability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000438:Alcohols; D000588:Amines; D001592:Benzyl Alcohols; D010626:Phenylethyl Alcohol