Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver.
D020642:Acatalasia; D000085:Acetates / Q000009:adverse effects; D000818:Animals; D002273:Carcinogens; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008830:Microbodies / Q000187:drug effects*; D008934:Mitogens; D009940:Organoids / Q000187:drug effects*; D011743:Pyrimidines / Q000009:adverse effects*; D051381:Rats; D011916:Rats, Inbred F344; D000509:alpha-Fetoproteins / Q000378:metabolism
D000085:Acetates; D002273:Carcinogens; D000960:Hypolipidemic Agents; D008934:Mitogens; D011743:Pyrimidines; D000509:alpha-Fetoproteins