Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles.
The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport.
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000494:pharmacology; D007210:Indoleacetic Acids / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology; D010525:Peripheral Nerves / Q000187:drug effects*; D010870:Pineal Gland / Q000032:analysis*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology
D007210:Indoleacetic Acids; D007211:Indoles; D009419:Nerve Tissue Proteins; D012701:Serotonin; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin; D010431:Pentoxifylline