title: Ulstrastructural study of leukodermic skin in Waardenburg-Klein syndrome.
abstract: The skin of a patient with Waardenburg syndrome has been studied by electron microscope. In leukodermic skin, there were neither melanocytes nor indeterminate cells; Langerhans cells were normal in number and distribution. On the edge of the lesion, melanocytes were few and appeared degenerated, with abnormal melanosomes; indeterminate cells were observed in suprabasal areas. Healthy skin also showed melanosome abnormalities. These findings are discussed and compared with the characteristics of piebaldism.
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000648:ultrastructure; D008544:Melanocytes / Q000648:ultrastructure; D012867:Skin / Q000648:ultrastructure*; D014849:Waardenburg Syndrome / Q000473:pathology*