Collagenase in synovial fluid.
Free collagenase activity was demonstrated in all 13 normal, 5 osteoarthrotic and 54 rheumatoid synovial fluids studied. Osteoarthrotic, normal, and rheumatoid fluids showed a free collagenase content increasing in that order. However, the total activities after trypsin activation did not differ significantly. The concentrations of alpha1-at and alpha2-M in synovial fluids reflected those in sera. The complex interactions between serum inhibitors, and free or latent collagenase released from both synovial cells and leukocytes are discussed.
D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D006801:Humans; D003012:Microbial Collagenase / Q000378:metabolism*; D010003:Osteoarthritis / Q000201:enzymology*; D013582:Synovial Fluid / Q000201:enzymology*; D014357:Trypsin / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D014357:Trypsin; D003012:Microbial Collagenase