Influence of dimercaprol on the early hepatic uptake of 111In-bleomycin in the BALB/c mouse.
Dimercaprol (BAL) administered 1 hr before 111In-bleomycin in the normal BALB/c mouse produced an early preferential hepatic loading of 111In-bleomycin without a loading of the spleen, skin, bone, or muscle. Liver-to-muscle ratios were increased about threefold under the influence of BAL. Liver (c BAL)/liver (s BAL) ratios also increased threefold at 3 hr whereas relative muscle uptake remained at about unity. Indium-111 chloride (colloid, pH 6.5) used as a control did not show a similar increase. The findings suggest that the kinetics and distribution of 111In-bleomycin in the normal BALB/c mouse can be influenced by pretreatment with BAL.
D000818:Animals; D001761:Bleomycin; D004112:Dimercaprol; D005260:Female; D007204:Indium; D008113:Liver Neoplasms / Q000175:diagnosis*; D051379:Mice; D008807:Mice, Inbred BALB C; D011877:Radionuclide Imaging
D007204:Indium; D004112:Dimercaprol; D001761:Bleomycin