[Placental origin of the progesterone binding protein in the pregnant guinea pig; immunohistoligical study].
The origin of the high affinity progesterone binding protein (PBP) occurring during pregnancy in the guinea pig serum has been investigated. An indirect immunofluorescence technique has been developed using a specific antiserum raised in rabbits. An accumulation of PBP-like immunofluorescent material was detected in the trophoblastic syncytium of the placenta tissue, whereas all other examined pregnant guinea pig organs gave negative reactions. It is concluded that this placental accumulation of immunoreactive PBP-like material may express a placental biosynthesis of this glycoprotein.
D000510:Alpha-Globulins / Q000096:biosynthesis*; D000818:Animals; D005260:Female; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D010920:Placenta / Q000378:metabolism* / Q000648:ultrastructure; D011247:Pregnancy; D011376:Progesterone-Binding Globulin / Q000096:biosynthesis*
D000510:Alpha-Globulins; D011376:Progesterone-Binding Globulin
Origine placentaire de la protéine de liaison de la progestérone chez le cobaye gravide; étude immunohistologique.