The depletion of the granules of argentaffin and argyrophile cells of monkey duodenum by reserpine.
The influence of reserpine (5 mg/kg) on the argentaffin and argyrophile cells has been studied in 4 monkeys, and in 4 controls. In the treated animals, there is a marked and obvious reduction in the number of argentaffin cells; the cells that remain also show signs of partial depletion. Reduction of the number of argyrophile cells is not obvious on casual examination, but cell counts reveal a statistically significant reduction. The persisting argyrophile cells show signs of partial depletion.
D000818:Animals; D002838:Chromaffin System / Q000187:drug effects*; D003594:Cytoplasmic Granules; D004386:Duodenum / Q000166:cytology*; D004759:Enterochromaffin Cells / Q000032:analysis / Q000187:drug effects*; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D012110:Reserpine / Q000494:pharmacology*; D012701:Serotonin / Q000032:analysis; D012834:Silver; D013194:Staining and Labeling
D012701:Serotonin; D012834:Silver; D012110:Reserpine