Immunological properties of dialysis retentates from penicillin.
Retentates from benzylpenicillin preparations marketed in Canada were used in immunological studies in order to determine if they were immunogenic in experimental animals with respect to anaphylactic antibody production. The retentates obtained consisted mainly of penicillin polymers. Impurities of protein nature were either insignificant or absent. The penicillin polymers were found to be non-immunogenic in Albino Wistar rats, Wistar Furth rats and Hartley guinea pigs. Furthermore, they were unable to effect positive PCA tests in rats passively sensitized to the penicilloyl determinant.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001202:Ascitic Fluid / Q000166:cytology; D003956:Dialysis; D004340:Drug Contamination; D004342:Drug Hypersensitivity; D006636:Histamine Release / Q000187:drug effects; D007114:Immunization; D008297:Male; D008407:Mast Cells / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D010400:Penicillin G / Q000276:immunology* / Q000494:pharmacology / Q000592:standards; D011108:Polymers; D051381:Rats; D012709:Serum Albumin / Q000032:analysis / Q000276:immunology
D011108:Polymers; D012709:Serum Albumin; D010400:Penicillin G