title: Sterilized hepatitis B (surface) antigen for production of specific antisera.
abstract: The combined treatment with beta-propiolactone and ultraviolet rays described for the sterilization of HBsAg-positive sera does not interfere with the purification procedures for the production of HBs antigen. The immunogenicity of the HBs antigen is retained.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000939:Epitopes; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D007122:Immunoelectrophoresis; D011420:Propiolactone / Q000494:pharmacology; D011817:Rabbits; D013242:Sterilization; D014466:Ultraviolet Rays
chemical_list: D000939:Epitopes; D006514:Hepatitis B Surface Antigens; D011420:Propiolactone