title: Loss of nitroglycerin from intravenous infusion sets.
abstract: During initial studies with nitroglycerin infusion in patients with acute myocardial infarction, higher doses than previously reported were required to achieve the desired haemodynamic effect. A flow-rate-dependent loss of drug from the plastic infusion set was demonstrated during simulated infusion. This loss was considerably reduced when nitroglycerin was infused from glass syringes through high-density polyethylene tubing.
mesh_terms: D000208:Acute Disease; D004058:Diffusion; D004347:Drug Interactions; D005898:Glass; D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation; D009203:Myocardial Infarction / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage*; D011095:Polyethylenes / Q000494:pharmacology; D012212:Rheology; D013594:Syringes
chemical_list: D011095:Polyethylenes; D005996:Nitroglycerin