Stimulation of T lymphocytes by autologous non-T lymphoid cells. Participation of HLA-D?
Non-T lymphoid cells were found to be able to stimulate autologous T cells in vitro. This "autologous" response was shown to be about 20% of the response to allogeneic unfractionated lymphocytes. The ability to induce autostimulation appeared to be a property of the Ig-positive lymphocyte fraction. Blocking experiments with allosera recognizing HLA-D-associated determinants suggested that the HLA-D determinants present on the stimulating cells might be involved in the stimulation of autologous T cells.
D002458:Cell Fractionation; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007104:Immune Adherence Reaction; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014182:Transplantation, Autologous
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens