title: The effects of some drugs--pentamidine, stibocaptate, Hoechst 33258, F 151, compound 'E' and Nifurtimox--on Onchocerca volvulus in chimpanzees.
abstract: Several drugs were investigated for action against Onchocerca volvulus in chimpanzees. Pentamidine at 4 mg/kg daily for 16 days had no filaricidal action; nor did stibocaptate at 10 mg/kg monthly for 8 months. Hoechst 33258, a substituted bis-benzamidazole, showed micro- and macrofilaricidal activity; F151 (an arsenical compound) showed a purely macrofilaricidal action; and Compound E (a reaction product of Hoechst 33258 and F151) was micro- and macrofilaricidal. The toxicity of the three last-mentioned compounds was high, and further trials were not made. Nifurtimox, at doses of up to 40 mg/kg for 10 days, was shown not be microfilaricidal, but there was a suggestion that this drug may have some macrofilaricidal action.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000965:Antimony / Q000494:pharmacology / Q000627:therapeutic use; D001152:Arsenicals / Q000494:pharmacology / Q000627:therapeutic use; D006690:Bisbenzimidazole / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D008297:Male; D009547:Nifurtimox / Q000494:pharmacology / Q000627:therapeutic use; D009854:Onchocerca / Q000187:drug effects*; D009855:Onchocerciasis / Q000188:drug therapy; D009942:Organometallic Compounds; D002679:Pan troglodytes; D010419:Pentamidine / Q000494:pharmacology / Q000627:therapeutic use; D004113:Succimer; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D001152:Arsenicals; D009942:Organometallic Compounds; D013386:Succinates; C013747:F151; D010419:Pentamidine; D000965:Antimony; C004443:stibocaptate; D004113:Succimer; D006690:Bisbenzimidazole; D009547:Nifurtimox