Secretin-induced histamine release in duodenal-ulcer patients.
Because a majority of duodenal-ulcer patients responded locally to intradermal secretin, skin samples from 7 patients with duodenal ulceration and 6 patients with goitre or cholelithiasis were incubated with "tris" buffer alone and with tris buffer containing 20 C.U./ml synthetic secretin or 100 microng/ml compound 48/80. Skin from duodenal-ulcer patients released significantly more histamine than did that of controls (p less 0-01). Histological examination of skin samples from these patients showed that the number of histamine-containing mast-cells averaged 5-7 per field and dropped to 1-2 per field after incubation with secretin. It is concluded that in a certain type of duodenal ulceration intradermal secretin releases histamine from mast-cells and thus induces a local anaphylactic reaction. This might prove suitable for preclinical ulcer diagnosis and/or for detection of patients at risk of acquiring that disease.
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced; D046508:Culture Techniques; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007271:Injections, Intradermal; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D008875:Middle Aged; D012306:Risk; D012633:Secretin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D012867:Skin / Q000473:pathology; D012877:Skin Manifestations; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D012633:Secretin; D003189:p-Methoxy-N-methylphenethylamine