Further definition of the encephalitogenic region for guinea pigs.
The effect on encephalitogenicity of using a serinyl substitution for the glutaminyl group in the peptide ser arg phe ser trp gly ala glu gly gln arg is reported. We conclude from these results that the function of the glutaminyl residue is assisting this peptide to produce allergic encephalomyelitis in guinea pigs is as a hydrogen donor-receptor.
D000595:Amino Acid Sequence; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced*; D005973:Glutamine / Q000378:metabolism; D006168:Guinea Pigs; D004676:Myelin Basic Protein / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D014364:Tryptophan / Q000378:metabolism
D004676:Myelin Basic Protein; D010446:Peptide Fragments; D005973:Glutamine; D014364:Tryptophan