title: Early degeneration of the cerebellar cortex, particularly the granular cells.
abstract: An 8 month old infant, who died of severe gastroenteritis, presented a degeneration of the cerebellar cortex involving cells arising from the outer granular layer as well as Purkinje and Golgi II cells. Residual Purkinje cells showed vacuolar change of the cell body and dendritic abnormalities. Related lesions were atrophy of the inferior olives and degeneration of the mossy fibers.
mesh_terms: D001284:Atrophy; D001933:Brain Stem / Q000473:pathology; D002525:Cerebellar Cortex / Q000473:pathology; D002526:Cerebellar Diseases / Q000473:pathology; D005260:Female; D005911:Gliosis; D006801:Humans; D007223:Infant; D009847:Olivary Nucleus / Q000473:pathology; D011689:Purkinje Cells