title: Effect of trypsin treatment on the antigenic characteristics of plaque variants of type-O 1 and type Asia-1 foot-and-mouth disease viruses.
abstract: Antigenic differences were demonstrated between the large and small plaque variants of both types O1 and Asia-1 foot-and-mouth disease viruses. Treatment of the large and small plaque variants of the viruses with trypsin essentially abolished the observed antigenic differences. Thus, these plaque variants have antigenically different trypsin-sensitive determinants that may influence their immunogenicity and infection capabilities.
mesh_terms: D000956:Antigens, Viral; D005537:Aphthovirus / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D002460:Cell Line; D000939:Epitopes; D014644:Genetic Variation / Q000187:drug effects*; D014357:Trypsin / Q000494:pharmacology*
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D014357:Trypsin