title: [HLA-DRW antigens and multiple sclerosis].
abstract: Previous studies of multiple sclerosis patients showed the existence of a positive association between multiple sclerosis and HLA-A3 and B7, as well as a negative association with B12, These observations have been confirmed. In addition, a more marked association has been observed with two recently identified B-cell antigens, DRW2 and DRW3, closely related to HLA-D locus. The presence of cold lymphocytotoxic antibodies was found to bear no relationship with those two specificities. These results suggest that two genes of the HLA-DR region may play a role in the pathogenesis of multiple sclerosis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000961:Antilymphocyte Serum / Q000032:analysis; D002648:Child; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology / Q000235:genetics / Q000276:immunology*
chemical_list: D000961:Antilymphocyte Serum; D000939:Epitopes; D006680:HLA Antigens
vernacular_title: Antigènes HLA-DRW et la sclérose en plaques.