Modulation of T-dependent cell-mediated immune responses by antigen-reactive cell opsonization and active suppression.
We have studied both specific and non-specific suppression in allogeneic combinations. On the one hand, achievement of specific suppression may circumvent both HVGR and GVHR, while on the other, Cy-resistant suppressor cells may exacerbate the GVHR in bone marrow graft recipients. A greater understanding of both of these aspects of modulation of immune responsiveness will be important in clinical bone marrow transplantation.
D000818:Animals; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D003520:Cyclophosphamide / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D000939:Epitopes; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007519:Isoantigens; D051379:Mice; D009895:Opsonin Proteins; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D000939:Epitopes; D007519:Isoantigens; D009895:Opsonin Proteins; D003520:Cyclophosphamide