Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline.
1. Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002784:Cholesterol / Q000096:biosynthesis*; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D015103:Droxidopa / Q000494:pharmacology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology
D013565:Sympatholytics; D003609:Dactinomycin; D003994:Bucladesine; D002784:Cholesterol; D003513:Cycloheximide; D010293:Pargyline; D006903:Hydroxymethylglutaryl CoA Reductases; D015103:Droxidopa; D009638:Norepinephrine