Splanchnic production of discoidal plasma high-density lipoprotein in man.
The morphology of human plasma high-density lipoprotein (H.D.L.) subfractions in arterial and hepatic venous blood from seven human subjects was investigated by electron microscopy. The H.D.L.3 subclass from both sources and the H.D.L.2 subclass from arterial blood were composed of spherical particles, identical with normal human peripheral venous H.D.L. In contrast, H.D.L.2 isolated from hepatic venous blood was composed of a mixture of spherical and discoidal particles. The latter tended to form rouleaux, and had a diameter similar to that of nascent H.D.L. particles obtained from the peripheral venous blood of a patient with lecithin: cholesterol acyltransferase deficiency. This supports the view that nascent H.D.L. is secreted into the splanchnic bed in man.
D000328:Adult; D002445:Celiac Artery; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007863:Lecithin Cholesterol Acyltransferase Deficiency / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000098:blood supply*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010316:Particle Size
D008075:Lipoproteins, HDL