Use of dextran 75 as a macromolecular agent in centrifugal leukapheresis.
Twenty-five leukaphereses were done by the Haemonetics system using citrated Dextran 75 in normal saline as anticoagulant, and were compared with a much larger series using hydroxyethyl starch (HES) with and without steroid premedication. The granulocyte and platelet yields were only minimally different between the two agents. Both were inferior in granulocyte collection to the group that was premedicated with a steroid. Dextran is thus a satisfactory substitute for HES in leukapheresis with this system.
D000925:Anticoagulants; D001803:Blood Transfusion / Q000379:methods*; D002469:Cell Separation / Q000592:standards; D002498:Centrifugation; D003911:Dextrans; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D017708:Leukocyte Transfusion
D000925:Anticoagulants; D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives