title: Effect of inhibitors of sterol biosynthesis on growth and sexuality of Pythium and Zygorhynchus.
abstract: Seven commercial inhibitors of sterol biosynthesis were tested for their effect upon vegatative growth and sexuality in Pythium acanthicum and Zygorhynchus moelleri. Five compounds (SKF 525, Chlorpropamide, Tolbutamide, Benzmalacene, AY 9944) inhibited both growth and sexuality of both fungi and two (SKF 7732 and SKF 7997) were ineffective. Pythium was more sensitive to the activity of the inhibitors than was Zygorhynchus. None of the compounds tested inhibited sexuality without similarly reducing vegetative growth.
mesh_terms: D002747:Chlorpropamide / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D008298:Maleates / Q000494:pharmacology; D009090:Mucorales / Q000187:drug effects* / Q000254:growth & development; D011335:Proadifen / Q000494:pharmacology; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development; D014044:Tolbutamide / Q000494:pharmacology; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride / Q000494:pharmacology
chemical_list: D008298:Maleates; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; D014044:Tolbutamide; D011335:Proadifen; D002747:Chlorpropamide