[Study of the histaminergic mechanisms of the action of malaben].
In rabbits (intact and with experimental myocardial infarction) histamine metabolism (histamine content and diaminoxidase activity) following introduction of malaben was studied. In intact animals the ability of malaben to reduce the blood histamine level and to activate diaminoxidase was discovered. Administration of malaben in experimental myocardial infarction promotes a quicker normalization of the disturbed metabolism of histamine.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D000208:Acute Disease; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D062365:Aminobenzoates / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D006632:Histamine / Q000097:blood; D006633:Histamine Antagonists; D006636:Histamine Release / Q000187:drug effects*; D008314:Malonates / Q000494:pharmacology / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D011817:Rabbits; D013997:Time Factors; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D006633:Histamine Antagonists; D008314:Malonates; D062366:para-Aminobenzoates; C002593:disodium 4,4'-9((1,3-dioxo-1,3-propanediyl)diimino)dibenzoate; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D010129:4-Aminobenzoic Acid
Izuchenie gistaminérgicheskikh mekhanizmov deĭstviia malabena.