title: Effects of antiprostatic agents on 5alpha-dihydrotestosterone binding to rat hypophyseal and hypothalamic cytosol macromolecules.
abstract: The binding of 5alpha-dihydrotestosterone to the hypophyseal and hypothalamic cytosol macromolecules prepared from castrated male rats was observed. The effects of antiprostatic agents on 5alpha-dihydrotestosterone binding to both hypophyseal and hypothalamic cytosol macromolecules was examined. Cyproterone acetate and chlormadionone acetate showed the significant inhibiting effects on 5alpha-dihydrotestosterone binding to 7-8 S macromolecules of cytosol from both hypophysis and hypothalamus. SCH 13521 and AA 560 did also affect 5alpha-dihydrotestosterone binding to 7-8 S macromolecules of cytosol from both tissues.
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D002715:Chlormadinone Acetate / Q000494:pharmacology; D003534:Cyproterone / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008297:Male; D051381:Rats
chemical_list: D000726:Androgen Antagonists; D046911:Macromolecular Substances; D013196:Dihydrotestosterone; D002715:Chlormadinone Acetate; D003534:Cyproterone