25-Hydroxylation of vitamin D in primary biliary cirrhosis.
The ability to 25-hydroxylate vitamin D was investigated in thirty-nine patients with symptomatic primary biliary cirrhosis (P.B.C.). In seven previously untreated patients serum-25-hydroxy-vitamin-D (25-OHD) concentration increased after regular monthly injections of vitamin D. After a single injection of vitamin D in eight P.B.C. patients serum-25-OHD did not change significantly over 12 days; in contrast there were significant increases in eight normal subjects and in seven patients with nutritional osteomalacia. Twenty-three of twenty-five P.B.C. patients on regular vitamin-D therapy had normal serum-25-OHD values. These results indicate that serum-25-OHD concentrations become normal in P.B.C. if adequate amounts of vitamin D are presented to the liver as substrate.
D000328:Adult; D000368:Aged; D004872:Ergocalciferols / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood / Q000378:metabolism*; D007273:Injections, Intramuscular; D008099:Liver / Q000378:metabolism; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000150:complications / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology
D004872:Ergocalciferols; D006887:Hydroxycholecalciferols