IgE-induced changes in human basophil cyclic AMP levels.
We studied a unique patient with 77% basophils, not different from normal by a number of criteria, in order to measure the changes in cyclic AMP level associated with IgE-mediated histamine release. In accordance with previous hypothesis and circumstantial evidence, anti-IgE challenge led to a significant fall in the cyclic AMP level which preceded histamine release.
D001491:Basophils / Q000276:immunology / Q000378:metabolism*; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology; D000242:Cyclic AMP / Q000276:immunology / Q000378:metabolism*; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E; D007951:Leukemia, Myeloid / Q000097:blood / Q000276:immunology
D007073:Immunoglobulin E; D000242:Cyclic AMP