title: Silicon, fibre, and atherosclerosis.
abstract: A logical argument can be made for the hypothesis that lack of silicon may be an important aetiological factor in atherosclerosis. As silicic acid or its derivatives, silicon is essential for growth. It is found mainly in connective tissue, where it functions as a cross-linking agent. Unusually high amounts of bound silicon are present in the arterial wall, especially in the intima. Various kinds of dietary fibre have been reported to be effective in preventing experimental models of atherosclerosis, reducing cholesterol and blood-lipid levels, and binding bile acids in vitro. Exceptionally large amounts of silicon (1000 to 25 000 p.p.m.) were found in fibre products of greatly varying origin and chemical composition which were active in these tests. Inactive materials, such as different types of purified cellulose, contained only negligible quantities of the element. It is concluded that silicate-silicon may be the active agent in dietary fibre which affects the development of atherosclerosis. Two out of three samples of bran also had relatively low levels, which could explain why bran does not lower serum-cholesterol. The fact that atherosclerosis has a low incidence in less developed countries may be related to the availability of dietary silicon. Two instances are presented where silicon is reduced by industrial treatment: white flour and refined soy products were much lower in silicon than--their respective crude natural products. The chemical nature of silicon in different types of fibre is not known. It could exist as orthosilic acid, polymeric silicic acid, colloidal silica (opal), dense silica concentrations, or in the form of organically bound derivatives of silicic acid (silanolates). Possible mechanisms of action are discussed.
mesh_terms: D000924:Anticholesteremic Agents; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002482:Cellulose / Q000032:analysis / Q000627:therapeutic use; D004043:Dietary Fiber / Q000032:analysis / Q000627:therapeutic use; D002523:Edible Grain / Q000032:analysis; D005433:Flour / Q000032:analysis; D006801:Humans; D010368:Pectins / Q000032:analysis; D012825:Silicon / Q000032:analysis / Q000627:therapeutic use; D013025:Glycine max / Q000032:analysis
chemical_list: D000924:Anticholesteremic Agents; D004043:Dietary Fiber; D010368:Pectins; D002482:Cellulose; D012825:Silicon