The occurrence of homoreactant factors and the examination of their influence on IgG synthesis.
Authors studied the occurrence of antibodies agglutinating IgG determinants with Rh positive red blood cells covered with IgG molecules of anti-Rh(D) activity treated with papain, pepsin, and trypsin. The occurrence of Fab antibodies was studied in the sera of newborn and of 1-6 years old healthy children, further on quantitative immunoglobulin assays were performed in these to determine whether homoreactant antibodies influence IgG production. Based on their results authors conclude that homoreactant antibodies do not influence IgG production. Authors assume a role in the IgG catabolism viz., they are involved in the elimination of antigen-antibody complexes.
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007223:Infant; D010206:Papain; D010434:Pepsin A; D014357:Trypsin
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D014357:Trypsin; D010206:Papain; D010434:Pepsin A