Coordination behaviour of antithyroid drugs against the Fe(I)(NO)2 group in solution: ESR and FT-NMR study.
The binding sites of some types of antithyroid drugs in the presence of the Fe(I)(NO)2 paramagnetic probe were investigated. Coordination behaviour in solution of different structured ligands was determined by means of ESR parameters and 13C FT-NMR spectra. Selective isotopic substitution with 15NO combined with computer simultation was used to elucidate overlapping ESR patterns. A correlation between chemical structure and antithyroid activity of the pharmacological bases is suggested.
D000814:Aniline Compounds; D013956:Antithyroid Agents; D001665:Binding Sites; D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds; D009682:Magnetic Resonance Spectroscopy; D009573:Nitrites; D010636:Phenols; D013329:Structure-Activity Relationship; D013854:Thioamides
D000814:Aniline Compounds; D013956:Antithyroid Agents; D005296:Ferrous Compounds; D009573:Nitrites; D010636:Phenols; D013854:Thioamides