Aetiology of juvenile-onset diabetes. A prospective study.
110 people in whom insulin-dependent diabetes developed when they were less than 30 years old were studied as soon as possible after diagnosis. There was evidence for clustering of cases with BW15-positive phenotypes during the winter peak (1976) but not during the autumn peak (1975). Subjects who were BW15-positive, and in particular those who were both B8 and BW15-positive, had higher neutralising antibody titres to Coxsackle virus types B1-B4 58% of cases had islet-cell antibodies (I.C.A.), but the presence of I.C.A. was not correlated with HLA phenotypes or viral antibody titres. In 41 subjects (37%), who gave a definite history of antecedent illness, evidence indicated that this was a precipitating infection and not the initiating event producing islet-cell damage. Nearly half the subjects had had diabetic symptoms for more than 4 weeks before diagnosis.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D001323:Autoantibodies / Q000302:isolation & purification; D001327:Autoimmune Diseases; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications / Q000382:microbiology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics; D004770:Enterovirus / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000302:isolation & purification; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D010641:Phenotype; D011446:Prospective Studies; D012621:Seasons
D000914:Antibodies, Viral; D001323:Autoantibodies; D006680:HLA Antigens