title: Selective decontamination of the digestive tract of Syrian hamsters.
abstract: Conventional Syrian hamsters colonized with aerobic gram-negative bacteria such as Pasteurella pneumotropica and various Enterobacteriaceae species were successfully and permanently freed from these microorganisms by oral treatment for 4 weeks with dihydrostreptomycin and 'Orabase' premixed with appropriate antibiotics. Concomitant oral treatment with dimetridazol for the elimination of intestinal flagellates was unsuccessful. During treatment the animals were maintained under germ-free isolation conditions.
mesh_terms: D000818:Animals; D006224:Cricetinae / Q000382:microbiology*; D004064:Digestive System / Q000382:microbiology*; D004096:Dihydrostreptomycin Sulfate / Q000494:pharmacology; D004131:Dimetridazole / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D056890:Eukaryota / Q000187:drug effects; D005856:Germ-Free Life; D007422:Intestines / Q000469:parasitology; D008647:Mesocricetus / Q000382:microbiology* / Q000469:parasitology; D009355:Neomycin / Q000494:pharmacology; D011549:Pseudomonas / Q000187:drug effects
chemical_list: D009355:Neomycin; D004131:Dimetridazole; D004096:Dihydrostreptomycin Sulfate