Effect of co-trimoxazole on normal creatinine clearance.
The effect of co-trimoxazole on creatinine clearance was studied in six individuals with normal kidney function. The mean decrease in creatinine clearance during treatment was 47 ml/min and the mean increase in plasma-creatinine was 0.27 mg/dl (P less than 0.01). Although creatinine clearance decreased by 29%, sodium excretion increased by 22%. Discontinuation of co-trimoxazole resulted in a prompt return of creatinine clearance to pretreatment values, and a consistent antinatriuresis.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects; D004338:Drug Combinations; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007677:Kidney Function Tests; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D004338:Drug Combinations; D014295:Trimethoprim; D003404:Creatinine; D013420:Sulfamethoxazole