title: Use of prostaglandin E1 in infants with d-transposition of the great arteries and intact ventricular septum.
abstract: Prostaglandin E1 was used to treat five infants with d-transposition of the great arteries and intact ventricular septum who had persistent severe hypoxemia after the creation of an interatrial communication. Three infants had a dramatic improvement in systemic arterial oxygen saturation associated with dilation of the ductus arteriosus; in two of the three cases urgent surgery was avoided. Two infants had no clinical evidence of increased ductal shunting and no improvement in oxygen saturation. A trial of prostaglandin E1 is recommended for treatment of severe hypoxemia in infants with d-transposition of the great arteries with intact ventricular septum if the presence of a large atrial septal defect is established.
mesh_terms: D006328:Cardiac Catheterization; D004106:Dilatation; D004341:Drug Evaluation; D004373:Ductus Arteriosus / Q000187:drug effects*; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D007261:Infusions, Intra-Arterial; D008297:Male; D008722:Methods; D010166:Palliative Care; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D014188:Transposition of Great Vessels / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D011459:Prostaglandins E, Synthetic