Demonstration and partial characterization of 22-nm HBsAg and Dane particles of subtype HBsAg/ady.
The present paper describes the demonstration of d, y, w, and r HBsAg determinants in one serum. It was shown that there are two populations of HBsAg particles: HBsAg/ad and HBsAg/ady. All complete Dane particles were of subtype HBsAg/ady. Further characterization of HBsAg/ady particles did not reveal morphologic differences when they were compared with HBsAg/ad and HBsAg/ay particles. An HBsAg/ady phenotype may be the result of a double infection with hepatitis B viruses or exchanges of DNA sequences that determine HBsAg/ay and HBsAg/ad to form a new genotype.
D000328:Adult; D000906:Antibodies / Q000276:immunology; D001667:Binding, Competitive; D002353:Carrier State / Q000276:immunology; D003378:Counterimmunoelectrophoresis; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D005260:Female; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D011863:Radioimmunoassay
D000906:Antibodies; D000939:Epitopes; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens