title: The production and control of anti--venous sera.
abstract: This paper describes the species of venomous snakes found in Costa Rica as well as anti-venom sera prepared by the Instituto Clodomiro Picado: polyvalent sera for use in human or veterinary medicine, and anti-Micrurus and anti-Lachesis monovalent sera. These sera are prepared in horses, purified with ammonium sulphate, then concentrated and delivered either in liquid or freeze-dried form. Controls are in accordance with NIH recommendations. For cases of hypersensitivity to horse serum, a polyvalent anti-Bothrops and anti-Crotalus serum from sheep has been prepared.
mesh_terms: D000569:Americas; D000818:Animals; D000997:Antivenins / Q000276:immunology*; D001688:Biological Products; D002489:Central America; D003364:Costa Rica; D003435:Crotalid Venoms / Q000633:toxicity; D004546:Elapid Venoms; D007106:Immune Sera; D007115:Immunization Schedule; D009500:Neutralization Tests; D012911:Snakes
chemical_list: D000997:Antivenins; D001688:Biological Products; D003435:Crotalid Venoms; D004546:Elapid Venoms; D007106:Immune Sera