Bleomycin effects on malignant tumors of the male genitalia.
Bleomycin was applied alone or in combination with actinomycin D, vinblastine, radiation and/or surgery in cancer of the penis (6) and testis (6). In early stages of penile cancer (T2 N0 M0) a total response was noted. The failure in advanced stages is discussed. In terato-, embryonal- and choriocarcinomas of the testis (T2-4 N0-2 M0-1) remarkable responses of short and long duration were observed in all patients. The reasons for different biological action are discussed.
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004407:Dysgerminoma / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000188:drug therapy*; D013724:Teratoma / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy*
D001761:Bleomycin