Plasma vitamin D-binding globulin in vitamin D deficiency, pregnancy and chronic liver disease.
Plasma concentrations of vitamin D-binding globulin were measured by radial immunodiffusion in healthy subjects, pregnancy, and during oestrogen therapy. Subjects with disorders of vitamin D metabolism (dietary deficiency, malabsorption, anticonvulsant therapy, chronic liver disease) were also studied. Neither sex nor age influenced the plasma vitamin D-binding globulin concentration in healthy subjects, but there was a significant increase in concentration during pregnancy and oestrogen therapy. Elevated levels were found in vitamin D deficient elderly but not younger subjects, while levels in subjects with chronic liver disease were significantly reduced. Normal levels of vitamin D-binding globulin were present in hypervitaminosis D and no vitamin D-binding globulin was detected in human milk. No correlation was observed between plasma 25-hydroxycholecalciferol levels and plasma vitamin D-binding globulin concentrations.
D000328:Adult; D000368:Aged; D000375:Aging; D000510:Alpha-Globulins / Q000032:analysis; D000927:Anticonvulsants / Q000009:adverse effects; D002352:Carrier Proteins / Q000097:blood*; D002908:Chronic Disease; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D014807:Vitamin D / Q000009:adverse effects; D014808:Vitamin D Deficiency / Q000097:blood*
D000510:Alpha-Globulins; D000927:Anticonvulsants; D002352:Carrier Proteins; D004967:Estrogens; D014807:Vitamin D