Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines.
Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.
D000818:Animals; D003080:Cold Temperature; D000939:Epitopes; D005289:Ferrets; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines; D009975:Orthomyxoviridae / Q000276:immunology; D011995:Recombination, Genetic; D014613:Vaccines, Attenuated
D000939:Epitopes; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated