Effect of norepinephrine on in vitro histamine release from rat mast cells.
The effect of norepinephrine on compound 48/80-induced histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine, within the concentration range 10(-5)--10(-3) M, exerts a significant, dose-related, repressive effect. This effect is greatly potentiated by the beta-antagonist practolol (10(-3) M), throughout the concentration range of 10(-11)--10(-3) M norepinephrine. Methoxyamine, a selective alpha-adrenergic agonist, also represses histamine release in a dose-dependent manner; however, it is not as potent as norepinephrine. The present results would seem to suggest that the repressive effect on histamine release, observed within a low concentration range of norepinephrine, may be due to alpha-adrenoceptor mechanisms.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008729:Methoxamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine; D011433:Propranolol; D008729:Methoxamine; D011217:Practolol; D009638:Norepinephrine