Frequency of eye complaints and rashes among patients receiving practolol and propranolol.
Among 71 patients treated with practolol by general practitioners, eye complaints were recorded in the case-notes of 14 (20%) during treatment, compared with 4 (6%) during equal periods before the drug was prescribed. Half the patients with eye complaints also had a rash while receiving practolol. These findings, which were not due to greater numbers of attendances during treatment nor to awareness of the hazards of the drug, suggest that mild eye complaints were relatively common among patients treated with practolol. Among 246 patients treated with propranolol, the numbers with eye complaints before and during treatment were similar, although there was a significant excess of patients with both an eye complaint and a rash during treatment.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D003231:Conjunctivitis / Q000139:chemically induced* / Q000453:epidemiology*; D003316:Corneal Diseases / Q000139:chemically induced* / Q000453:epidemiology; D004485:Eczema / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D006980:Hyperthyroidism / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011217:Practolol / Q000009:adverse effects* / Q000627:therapeutic use; D011433:Propranolol / Q000009:adverse effects* / Q000627:therapeutic use
D011433:Propranolol; D011217:Practolol