Defective neutrophil migration in sarcoidosis.
A quantitative skin-window-chamber technique was used to study 13 patients with sarcoidosis. Neutrophil migration into the chambers in 24 hours was less than that in normal subjects. Chemotaxis of neutrophils in vitro was normal. Serum from patients with sarcoidosis inhibited neutrophil chemotaxis more than normal serum.
D002634:Chemotaxis, Leukocyte; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000473:pathology / Q000502:physiology*; D012507:Sarcoidosis / Q000097:blood*; D012884:Skin Window Technique