title: [Effect of L-asparaginase on humoral immune response against protein antigens in mice (author's transl)].
abstract: The immune response of CBA-mice against alum adsorbed BGG is depressed by daily injections of 20, 40 and 80 I.U. of asparaginase (Crasnitin) from the first day before to the second day after immunisation. After a period of 14 or 21 days the antibody levels slowly rises again. The early IgM-response is not altered. Pretreatment of the animals with BGG-asparaginase conjugate has not any influence on the immune reaction. The conjugate is because its high molecular weight more immunogenic than the BGG and the enzyme allone respectively.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D000941:Antigens; D001215:Asparaginase / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011292:Premedication; D011485:Protein Binding; D013997:Time Factors; D005719:gamma-Globulins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000941:Antigens; D005719:gamma-Globulins; D001215:Asparaginase
vernacular_title: Zur Beeinflussung der humoralen Immunantwort der Maus gegen Proteinantigene mit L-Asparaginase.