Possible effects of growth hormone on development of acute lymphoblastic leukaemia.
Growth hormone (G.H.) or a G.H.-dependent somatomedin may be involved in the process of acute lymphoblastic leukaemia (A.L.L.). Growth hormone has a trophic effect on lymphoid tissue and also specific receptors on lymphocytes, most probably T cells. Hypophycess. Resting concentrations of G.H. and somatomedin activity are raised in some children with A.L.L. and may be reduced after remission is achieved. It is suggested that control of G.H. and/or somatomedin concentrations may be necessary for adequate treatment of some cases of A.L.L. in children.
D000293:Adolescent; D000818:Animals; D002648:Child; D013006:Growth Hormone / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007016:Hypophysectomy; D007942:Leukemia, Experimental / Q000209:etiology / Q000628:therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy; D008221:Lymphoid Tissue / Q000473:pathology; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D013002:Somatomedins / Q000502:physiology; D013004:Somatostatin / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000473:pathology / Q000502:physiology
D011956:Receptors, Cell Surface; D013002:Somatomedins; D013004:Somatostatin; D013006:Growth Hormone