title: [Controlled study on the efficacy of external treatment in surface-near thrombophlebitis].
abstract: The efficacy of an organo-heparinoid ointment (Hirudoid 40,000) compared with a placebo ointment was tested in a double blind trial on 40 patients with post-operative infusion thrombophlebitis. It was possible to provide objective data by means of the 125I-fibrinogen test for accelerated regression of thrombi following treatment with organo-heparinoid. The differences found between the 2 treatment groups were statistically significant. The clinical results conformed largely to the measured data. Especially pain and swelling were favourably affected by treatment with the active compound. 1 case of local allergic reaction to organo-heparinoid was observed. No further side-effects were seen.
mesh_terms: D004341:Drug Evaluation; D005260:Female; D005340:Fibrinogen / Q000302:isolation & purification; D006496:Heparinoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011183:Postoperative Complications; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
chemical_list: D006496:Heparinoids; D009824:Ointments; D005340:Fibrinogen
vernacular_title: Kontrollierte Studie zur Wirksamkeit einer externen Therapie bei oberflächennaher Thrombophlebitis.