Prevention by bedtime cimetidine of duodenal-ulcer relapse.
45 patients with healed duodenal ulcers completed a six-month double-blind trial to compare the effects of cimetidine and placebo on the prevention of duodenal-ulcer relapse. A single bedtime dose of cimetidine (800 mg) was given and ulcer relapse was assessed endoscopically at regular intervals. At the end of the six-month trial, 16 of the 21 (76%) cimetidine-treated patients remained ulcer-free compared with only 3 of the 24 (12.5%) placebo-treated patients. No untoward effects of this treatment were observed.
D000328:Adult; D002648:Child; D002927:Cimetidine / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012008:Recurrence; D013997:Time Factors
D006146:Guanidines; D010919:Placebos; D002927:Cimetidine