In vitro secondary MLR. III: Hybrid histocompatibility determinants.
With cells obtained from long-term mixed lymphocyte culture (MLC) we have have demonstrated hybrid histocompatibility determinants that are recognized as mixed lymphocyte reaction (MLR)-stimulating determinants. Hybrid determinants can also be detected (1) in an in vitro assay for effector cells that measure inhibition of immunoglobulin secretion by LPS-blasts, and (2) in DTH-like responses of in vitro-primed cells injected into "B" mice and challenged in vivo with stimulator cells. The possible implications of these findings for the physiologic function of MLR determinants are discussed.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D003433:Crosses, Genetic; D000939:Epitopes; D006649:Histocompatibility Antigens; D006824:Hybridization, Genetic; D008070:Lipopolysaccharides / Q000276:immunology; D016031:Liver Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera
D000941:Antigens; D000939:Epitopes; D006649:Histocompatibility Antigens; D008070:Lipopolysaccharides