title: [Isolation and analysis of encephalitogenic fractions of spinal cord proteins].
abstract: Main encephalitogenic protein was isolated from bovine medulla spinalis and separated into homogenous polypeptide fractions by gel filtration; some of these fractions had the high encephalitogenic activity. The main protein and its fractions, possessing the encephalitogenic activity, caused a development of cross-reacting antibodies and a sensitization to intracutaneous administration of encephalitogenic preparations in animals. Non-encephalitogenic main protein sensitized animals only to this protein and did not induce the formation of distinct amount of antibodies. The amino acid composition of the encephalitogenic polypeptide is exhibited.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000906:Antibodies / Q000032:analysis; D002417:Cattle; D003168:Complement Fixation Tests; D004681:Encephalomyelitis, Autoimmune, Experimental; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D004676:Myelin Basic Protein / Q000032:analysis / Q000276:immunology / Q000302:isolation & purification*; D013116:Spinal Cord / Q000032:analysis* / Q000276:immunology
chemical_list: D000596:Amino Acids; D000906:Antibodies; D004676:Myelin Basic Protein
vernacular_title: Vydelenie i analiz éntsefalitogennykh fraktsiĭ belkov spinnogo mozga.