title: [Acute and subacute intracranial hepatoma with hemophilia A--two cases report (author's transl)].
abstract: Two cases of traumatic intracerebral hemorrhage in hemophiliac are presented. Case 1 was a 3-year-old boy, who had a mild trauma and became semicomatous. The carotid angiogram showed the findings of intracerebral hematoma and extravasation of contrast medium from the temporal branch of the middle cerebral artery. Evacuation of hematoma was successfully performed under human AHF administration. Postoperatively, the human AHF was administrated to maintain 30% of the plasma concentration of the VIII factor for 3 weeks. He discharged without any neurological deficit. Case 2 was a 14-year-old boy who had experienced several episodes of hemorrhage in nose and knee joints. He had a minor head trauma. Then, 12 days later, he became drowsy and the left hemiparesis developed. The right carotid angiogram revealed the presence of thin subdural hematoma and intracerebral hematoma. From clinical state, however, the conservative treatment was selected and human AHF was administered. The concentration of plasma VIII factor was kept in 30% with human AHF for 2 weeks like case 1. He completely recovered. The authors believe that the human AHF is very effective and 30% of plasma VIII factor is enough for treatment of intracerebral hemorrhage in hemophiliac.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000601:surgery; D002675:Child, Preschool; D002908:Chronic Disease; D005169:Factor VIII / Q000627:therapeutic use; D006406:Hematoma / Q000150:complications* / Q000601:surgery; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D008297:Male; D010166:Palliative Care
chemical_list: D005169:Factor VIII