Significance of HLA-D/DR matching in renal transplantation.
A low mixed-lymphocyte-culture response, indicating matching for HLA-D, was associated with a relatively good chance of graft survival in 62 recipients of renal transplants from living relatives mismatched for one or two HLA A and/or B antigens. In 96 cadaveric transplants prospectively typed for HLA-DR antigens, compatibility for these antigens improved the prognosis, irrespective of matching for HLA A and B antigens. In cadaveric transplants, a positive B-cell cross-match test before transplantation tended to predict inferior graft survival.
D000017:ABO Blood-Group System; D001402:B-Lymphocytes / Q000276:immunology; D002102:Cadaver; D005069:Evaluation Studies as Topic; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis*; D006238:Haploidy; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D011379:Prognosis; D011446:Prospective Studies; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D000017:ABO Blood-Group System; D006680:HLA Antigens