Effect of bilateral adrenalectomy and parenteral betamethasone on gastric mucosal mast cell population in albino rats.
The histamine-laden mast cells of gastric mucosa in albino rats are shown to degranulate on administration of Betamethasone, but they increase in number in adrenalectomized rats. It is concluded that Betamethasone, and also adrenal glucocorticoids increase gastric secretion by liberating histamine from mast cells and histamine in turn acts on the gastric glands.
D000315:Adrenalectomy; D000818:Animals; D001623:Betamethasone / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology* / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013997:Time Factors
D001623:Betamethasone