Tolerance to azobenzenearsonate: preferential loss of the major normal cross-reactive idiotype.
A specific tolerant state was induced in A/J mice to the hapten p-aminobenzenearsonate (Ars) by the injection of deaggregated conjugates of Ars and human gemma-globulin (Ars-DHGG). The kinetics of tolerance to Ars-DHGG was found to be identical to that of B cell tolerance to human gamma-globulin alone. The ability to produce antibody (anti-Ars) bearing the major normal cross-reactive idiotype was found to be preferentially lost. In addition, recovery of the ability to produce anti-Ars bearing this cross-reactive idiotype was found to be delayed as compared to the total anti-Ars response upon spontaneous loss of tolerance.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D001391:Azo Compounds / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D051379:Mice; D010132:p-Azobenzenearsonate / Q000276:immunology*
D000906:Antibodies; D001391:Azo Compounds; D000939:Epitopes; D010132:p-Azobenzenearsonate