title: CEA and non-specific cross-reacting antigen (NCA) in medullary carcinomas of the thyroid.
abstract: An immunohistological study of five cases of medullary carcinoma of the thyroid was undertaken with monospecific antisera against CEA and NCA. CEA was present in different areas of the tumors: cell cytoplasm, cell membrane at its apical pole when the tumor had a pseudoglandular organization, deposits in the lumen of pseudoglands, and peri- and extra-cellular deposits. From these extra-cellular deposits, CEA could easily reach the circulation, thus causing rising serum levels up to high values. NCA was found in the same tumors and in the same localizations.
mesh_terms: D000941:Antigens / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002462:Cell Membrane / Q000276:immunology; D003429:Cross Reactions; D003593:Cytoplasm / Q000276:immunology; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D013964:Thyroid Neoplasms / Q000276:immunology*
chemical_list: D000941:Antigens; D002272:Carcinoembryonic Antigen; D000939:Epitopes; D007106:Immune Sera