Age-related changes in chromatin of liver cell nuclei of different ploidity.
A comparison of the Feulgen hydrolysis curves and the chromatin compactness of the liver cell nuclei of young and old rats was made. It was found that the rate of DNA depurination and chromatin compactness are higher in the liver cell nuclei of old rats, both in di-and tetraploidal cells. The effect of fixation upon the course of the hydrolysis curves is discussed.
D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism* / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D003201:Computers; D004247:DNA / Q000378:metabolism; D008099:Liver / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D011003:Ploidies; D051381:Rats; D013194:Staining and Labeling
D002843:Chromatin; D004247:DNA