Proteolytic activity in CSF.
Proteolytic enzyme activity, present at both acid and neutral pH values, in cerebrospinal fluid, can be measured by a sensitive assay, which monitors the rate of 125I-basic protein breakdown on polyacrylamide gel electrophoresis. CSF cellular neutral proteinase and supernatant acid proteinase are increased in acute multiple sclerosis and in CNS infections.
D000208:Acute Disease; D002493:Central Nervous System Diseases / Q000201:enzymology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008214:Lymphocytes / Q000201:enzymology; D009103:Multiple Sclerosis / Q000201:enzymology*; D004676:Myelin Basic Protein / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology; D010447:Peptide Hydrolases / Q000134:cerebrospinal fluid*
D004676:Myelin Basic Protein; D010447:Peptide Hydrolases