Mixed lymphocyte culture search for HLA-D homozygous typing cells in the Hungarian inbred population of Ivád.
Six functionally HLA-D homozygous typing cells were identified by a restricted investigation into the Hungarian inbred population of Ivád. These putative HLA-D homozygous typing cells were then tested against a highly selected Scandinavian population sample of 60 individuals previously typed by histocompatibility reference reagents. The different HLA-D specificities could thus be identified: one closely matching HLA-Dw5, another resembling the Oslo LDoH specificity, while the last seems to be unique. Only one of the typing cells thus ascertained were HLA-B homozygous and were selected on the basis of the Ivád family structure and not on the basis of serological HLA typing.
D000939:Epitopes; D005260:Female; D005828:Genetics, Population; D006680:HLA Antigens / Q000032:analysis; D006720:Homozygote; D006801:Humans; D006814:Hungary; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D012537:Scandinavian and Nordic Countries
D000939:Epitopes; D006680:HLA Antigens