Spontaneous pneumothorax as a result of intensive cytotoxic chemotherapy.
Spontaneous pneumothorax occurring as a complication of the antitumor effect of cytotoxic chemotherapy has been reported in occasional cases of osteogenic sarcoma. Its occurrence in other tumors has not been described. This report describes two cases of this complication in patients with germinal tumors and discusses possible pathophysiologic mechanisms.
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000150:complications / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy*; D011030:Pneumothorax / Q000209:etiology*; D011247:Pregnancy; D012075:Remission, Spontaneous; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy*; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001761:Bleomycin; D003609:Dactinomycin; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin