[Adaptation to the action of several teratogens as a consequence of preliminary administration of pesticides to females].
The effect of DDT and lindane pesticides on the intensity of the teratogenic action of sodium acetylxalicylate (SA) and of the cabomate benlate group of pesticides was studied on Wistar rats given the mentioned pesticides from the onset of pregnancy. The teratogens were administered on the 10th and the 12th days of gestation, respectively. Preliminary administration of these pesticides was found to weaken the teratogenic and the embryotoxic action of benlate given in a dose of 250 mg/kg, and of SA administered in a dose of 400 mg/kg. When SA was given in a dose of 600 mg/kg preliminary administration of the pesticides decreased the postimplantation mortality of the embryos, but the number of fetuses with developmental anomalies was the same as in the isolated action of the preparation given in this dose.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002219:Carbamates; D003634:DDT / Q000506:poisoning*; D004347:Drug Interactions; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D007306:Insecticides / Q000506:poisoning*; D011247:Pregnancy; D051381:Rats; D012980:Sodium Salicylate / Q000506:poisoning*
D002219:Carbamates; D007306:Insecticides; D001556:Hexachlorocyclohexane; D003634:DDT; D012980:Sodium Salicylate
K voprosu ob adaptatsii k deĭstviiu nekotorykh teratogenov vsledstvie predvaritel'nogo vvedeniia samke pestitsidov