[Mechanical resistance of amidinated human erythrocytes].
The amidination reactions by means of dimethyl adipimidate (0.25-10.0 mM) or dimethyldodecane-imidate (0.1-1.0 mM) cause an alteration of the mechanical resistance of red blood cells. Low amidination results in peripheral cross-links of erythrocytes whose mechanical resistance increase relative to borate buffer treated cells. Increasing cross-linking reduces the mechanical resistance of erythrocytes, which finally appears to have become restored. The final state, however, is characterized by an almost complete cross-linking of the cell, which than no longer behaves like an osmometer.
D000578:Amidines / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D009995:Osmosis / Q000187:drug effects
D000578:Amidines
Mechanische Resistenz amidinierter Humanerythrozyten