title: Conditioned EEG desynchronization and seizure occurrence in patients.
abstract: Five patients with seizures poorly controlled by standard anticonvulsant medication, underwent EEG operant conditioning. The operant paradigm reinforced the production of low voltage fast activity while decreasing frequencies below 10 c/sec. Seizure frequency decreased in 2 patients, seizure severity was attenuated in 2 others, and one patient who was only given reinforecement for scalp EMG suppression whowed no change in seizure parameters. Pseudoconditioning and control periods ruled out placebo effects. A rationale for this phenomenon is proposed.
mesh_terms: D000328:Adult; D003216:Conditioning, Operant / Q000502:physiology*; D003344:Cortical Synchronization; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male