title: Urinary excretion of beta2 microglobulin after the induction of a diuresis. A study in healthy subjects.
abstract: An increased diuresis was induced in each of four healthy subjects by intravenous infusion of urea, saline and sodium bicarbonate and by an oral water load. The excretion of a low molecular weight protein (LMW-protein), beta2-Microglobulin (beta2mu), was determined by a radioimmunoassay, the urinary concentrations of the protein being in the range 0.007-0,3 mug/ml. The hourly excretion of beta2 mu was not significantly influenced by varying loads of water, sodium, and osmoles which suggests that the tub ular reabsorption of LMW-proteins is stable under these conditions and that even a moderately increased excretion of such proteins may reflect a distrubed proximal tubular function.
mesh_terms: D001609:Beta-Globulins / Q000652:urine*; D003404:Creatinine / Q000652:urine; D004231:Diuresis; D006801:Humans; D007684:Kidney Tubules / Q000502:physiology*; D007687:Kidney Tubules, Proximal / Q000503:physiopathology; D008297:Male; D009997:Osmotic Pressure; D011507:Proteinuria / Q000503:physiopathology; D011863:Radioimmunoassay; D012964:Sodium / Q000652:urine; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D001609:Beta-Globulins; D001613:beta 2-Microglobulin; D012964:Sodium; D003404:Creatinine