Morphometric investigations on endocrine glands. V. Changes in the testes of Wistar rats after application of chlormadinone acetate and norethisterone acetate.
In growth inhibiting tests of rat testes the tubular diameter and, somewhat less sensitive, the nuclear volume of the Leydig cell follow the weight changes. Chlormadinone acetate shows antigonadotropic activity only at high doses and a dose-dependent antiandrogenic activity. The dose-weight curve under norethisterone acetate has a minimum at 4.2 mg/rat/14 days; higher doses seem to be accompanied by androgenic efficiency.
D000818:Animals; D002467:Cell Nucleus; D002715:Chlormadinone Acetate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007985:Leydig Cells / Q000187:drug effects*; D008297:Male; D009640:Norethindrone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000254:growth & development
D002715:Chlormadinone Acetate; D009640:Norethindrone