Myoglobinaemia in Duchenne muscular dystrophy patients and carriers: A new adjunct to carrier detection.
Myoglobinaemia was detected in 14 of 18 patients with Duchenne muscular dystrophy (D.M.D.) with a sensitive specific complement-fixation assay. Myoglobinaemia was also detected in 10 of 16 known D.M.D. carriers, including 4 with normal serum-creatine-phosphokinase activity. 9 of 27 possible carriers also had myoglobinaemia. It is suggested that this assay is a useful adjunct to present methods of carrier detection in D.M.D.
D000293:Adolescent; D000328:Adult; D002648:Child; D003168:Complement Fixation Tests; D003402:Creatine Kinase / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D009211:Myoglobin / Q000097:blood*; D012737:Sex Factors; D014960:X Chromosome
D009211:Myoglobin; D003402:Creatine Kinase