title: Anti-allergic activities of a new benzopyranopyridine derivative Y-12,141 in rats.
abstract: Passive cutaneous anaphylaxis (PCA) mediated in rats by IgE-like antibodies against egg albumin or the benzylpenicilloyl determinant was inhibited in a dose-dependent manner by intravenous treatment with Y-12,141; the ED50 was 0.09--0.2 mg/kg. The inhibitory effect of Y-12,141 ON PCA was about 5 times as potent as that of disodium cromoglycate (DSCG). Oral treatment with Y-12,141 resulted in the inhibition of PCA, showing an ED50 of 2.5 mg/kg. This action of Y-12,141 on PCA was considered to be due to the inhibition of the release of allergic mediatros from mast cells in a manner similar to DSCG. The results suggest that Y-12,141 may have an anti-allergic activity.
mesh_terms: D000818:Animals; D001393:Azoles / Q000494:pharmacology*; D002867:Chromones / Q000494:pharmacology*; D004205:Cromolyn Sodium / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006633:Histamine Antagonists; D006636:Histamine Release / Q000187:drug effects; D006967:Hypersensitivity / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010400:Penicillin G / Q000276:immunology; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D001393:Azoles; D002867:Chromones; D006633:Histamine Antagonists; D013777:Tetrazoles; D007073:Immunoglobulin E; D010047:Ovalbumin; C020178:traxanox; D004205:Cromolyn Sodium; D010400:Penicillin G