The effect of combination chemotherapy on neutrophil function in cancer patients.
The effect of adjuvant and palliative combination chemotherapy (Vincristine, MeCCNU, 5-Fluorouracil) on neutrophil function was studied in 18 patients prior to and during the anticancer treatment. Neutrophil responsiveness was assessed by leukocyte chemotaxis and chemiluminescence. No impairment could be observed in the circulating phagocyte function in either of the 2 groups before or in connection with short or long-term treatment.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D009504:Neutrophils / Q000187:drug effects*; D010166:Palliative Care; D012673:Semustine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D012673:Semustine; D014750:Vincristine; D005472:Fluorouracil