[Treatment of chronic hepatitis. A comparative study of the effect azathioprine and (+)-cyanidanol-3].
The clinical, biochemical and histological results of the treatment of 2 groups of 8 patients each with chronic hepatitis (persistent or aggressive) treated with azathioprine (100mg daily) or (+)-cyanidanol-3(1.5g daily) are compared. The duration of treatmant was 6 months, with monthly examination during this period. The clinical results were comparable in the 2 groups. Among the liver function tests, (+)-cyanidanol-3 appeared superior in the case of total bilirubin, transaminases and BSP retention and azathioprine was superior as regards reduction of gamma-globulin, IgG and IgM. These different results appear to correspond to their different mechanisms of action. The tolerance was superior in the (+)-cyanidanol-3 group, in which no side effects were observed, whereas in the azathioprine group, treatment had to be temporarily interrupted in 3 patients showing leukopenia and/or thrombocytopenia. We therefore believe that it can be asserted that treatment with (+)-cyanidanol-3 yields results similar to those obtained with azathioprine, but being a non-immunosuppressive therapy is devoid of the severe consequences produced by a decrease in immunity in day-to-day clinical practice.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001578:Benzopyrans / Q000627:therapeutic use*; D001663:Bilirubin / Q000097:blood; D002392:Catechin / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006505:Hepatitis / Q000188:drug therapy*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013448:Sulfobromophthalein; D005719:gamma-Globulins / Q000032:analysis
D001578:Benzopyrans; D007136:Immunoglobulins; D005719:gamma-Globulins; D013448:Sulfobromophthalein; D002392:Catechin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001379:Azathioprine; D001663:Bilirubin
Zur Behandlung der chronischen Hepatitis. Eine vergleichende Studie zur Wirksamkeit von Azathioprin und (+)-Cyanidanol-3.