title: On the expressivity of aberration hot spots after treatment with mutagens showing delayed or non-delayed effects.
abstract: The intrachromosomal distribution patterns of chromatid aberrations induced by agents with delayed effects (as exemplified by ethanol and maleic hydrazide) were compared with those produced by agents with non-delayed effects (as exemplified by fast neutrons, X-rays and bleomycin). Despite nonrandomness of aberration distribution in all cases, the mutagens with nondelayed effects generally showed up with much less pronounced aberration hot spots than the mutagens with delayed effects. From the results obtained it is concluded that hot-spot expressivity is a characteristic "group-specific" feature of the two classes of mutagen and that aberration production during DNA replication (S-phase) by agents with delayed effects strongly favours a very pronounced aberration clustering, which is partly mutagen-specific. Possible causes of these differences with respect to hot-spot expressivity after treatment with mutagens showing non-delayed and delayed effects, respectively, are discussed.
mesh_terms: D001761:Bleomycin / Q000494:pharmacology; D002453:Cell Cycle; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects; D004261:DNA Replication; D000431:Ethanol / Q000494:pharmacology; D005214:Fast Neutrons; D008300:Maleic Hydrazide / Q000494:pharmacology; D009153:Mutagens; D010944:Plants; D014965:X-Rays
chemical_list: D009153:Mutagens; D001761:Bleomycin; D000431:Ethanol; D008300:Maleic Hydrazide