title: An experimental study on the effect of plasma expanders on blood coagulability.
abstract: The effect of various plasma expanders on blood coagulation was studied using the thromboelastography (TEG). Solutions of 5, 10, 20, and 50% concentration of each expander (6% low molecular weight hydroxyethyl-starch (6% Hespander), 3% dextran-40, 6% high molecular weight hydroxyethyl-starch (6 HES), and 6% dextran-70) or solvent (lactated Ringer solution and normal saline) in blood were prepared and their coagulability was examined by TEG. In the low molecular weight plasma expanders (6% Hespander and 3% dextran-40), in general, the coagulability decreased when the concentration was increased. In the high molecular weight plasma expanders (6 HES and 6% dextran-70), the coagulability increased slightly at low and high concentrations and the coagulability was reduced. As a conclusion, at clinically used concentrations of less than 20% in blood, changes in the TEG of the plasma expanders are minimum and have no clinical significance.
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001780:Blood Coagulation Tests; D003911:Dextrans / Q000494:pharmacology*; D004548:Elasticity; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D010952:Plasma Substitutes / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D013213:Starch / Q000031:analogs & derivatives*; D013917:Thrombin / Q000096:biosynthesis; D013925:Thromboplastin / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D012965:Sodium Chloride; D013213:Starch; D013925:Thromboplastin; D013917:Thrombin