Response of isolated axonal preparations to hyperosmoticity: evidence for a cellular volume regulation.
When submitted to a hyperosmotic stress, isolated axons of Callinectes sapidus shrink. Volume regulation is observed if the experiment is carried out by using serum from a crab adapted to sea water. 3' : 5'-AMP and dibutyryl AMP are also effective. A compound isolated from the hemolymph and having a molecular weight close to 10 000 mimics the effects of the serum and induces a partial regulation of the axonal volume.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D003386:Brachyura; D003839:Deoxyadenosines; D004837:Epinephrine / Q000494:pharmacology; D009994:Osmolar Concentration; D011188:Potassium / Q000494:pharmacology
D003839:Deoxyadenosines; D000249:Adenosine Monophosphate; D011188:Potassium; D004837:Epinephrine