title: Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease.
abstract: A unique cytochrome b which becomes incorporated into phagocytic vacuoles has been described in human neutrophils. This cytochrome b appears to be situated in the plasma membrane of these cells, and acts as a component of the microbicidal oxidase system. Absence or gross abnormality of this cytochrome b was demonstrated in all four patients with chronic granulomatous disease who were investigated, and reduced concentrations in two mothers known to be carriers of the disease.
mesh_terms: D002648:Child; D003580:Cytochromes / Q000172:deficiency*; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D010101:Oxygen Consumption; D010375:Pedigree; D009195:Peroxidase / Q000172:deficiency / Q000302:isolation & purification; D010587:Phagocytosis; D013053:Spectrophotometry / Q000379:methods
chemical_list: D003580:Cytochromes; D009195:Peroxidase