How the lower oesophageal sphincter affects submucosal oesophageal varices.
Oesophageal varices are found in the submucosa of the lower oesophageal sphincter (L.E.S.). Portagraphic studies after vasopressin administration showed occlusion of submucosal oesophageal varices and distension of the para-oesophageal veins. Oesophagography and endoscopy after administration of anticholinergics showed considerable dilatation of the submucosal oesophageal varices. Because vasopressin increases, and anticholinergics decrease, L.E.S. pressure it is suggested that L.E.S. pressure is an important factor in the development of submucosal oesophageal varices.
D001794:Blood Pressure / Q000187:drug effects; D004932:Esophageal and Gastric Varices / Q000188:drug therapy / Q000209:etiology*; D004943:Esophagogastric Junction / Q000098:blood supply*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology; D011169:Portal Vein / Q000503:physiopathology; D014667:Vasopressins / Q000627:therapeutic use; D014682:Vena Cava, Inferior / Q000503:physiopathology
D014667:Vasopressins