title: Cold-induced profuse sweating on back and chest. A new genetic entity?
abstract: Two sisters whose parents shared a grandfather had cold-induced sweating. Since childhood they had sweated profusely from the back and chest when exposed to environmental temperatures of 18 degrees to 7 degrees C. They had additional abnormalities--e.g., high palate and inability fully to extend the elbows--which neither their parents nor their sibs shared. The cold-induced sweating, which could not be stopped by a beta-adrenergic blocking agent, was abolished by postganglionic blockade with atropine sulphate. This indicates the possibility of a peripheral mechanism.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001285:Atropine / Q000008:administration & dosage; D001338:Autonomic Fibers, Postganglionic / Q000187:drug effects; D001340:Autonomic Nerve Block; D001415:Back; D003080:Cold Temperature / Q000009:adverse effects*; D004439:Eccrine Glands / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy / Q000235:genetics*; D011433:Propranolol / Q000008:administration & dosage; D012007:Rectum; D012881:Skin Temperature; D013545:Sweat Glands / Q000378:metabolism*; D013909:Thorax
chemical_list: D001285:Atropine; D011433:Propranolol