[Comparative study of histamine liberation after administration of anesthetic substances, curare agents and plasma substitutes in man].
The authors studied in 270 volunteers histamine liberation after administration of drugs. Definite histamine liberation was noted after propanidide, pentothal, methohexital, Alfatesine, and also after muscle relaxants including pancuronium bromide. Until now, among all the substances studies, both clinically and in the laboratory, after 4 years, only etomidate, according to their personal experience is not a histamine liberator. Similar results were observed after ketamine, but also after administration of Atosil (Phenergan) fenestil (Dimethendène) and Trasylol (Zymofren). As far as plasma susbtitutes are concerned, the search for mediators of the anaphylactoid and anaphylactic reactions should be considered in a differential way.
D000707:Anaphylaxis / Q000139:chemically induced* / Q000209:etiology; D000768:Anesthesia, General; D000777:Anesthetics / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D010952:Plasma Substitutes / Q000009:adverse effects*
D000777:Anesthetics; D003473:Neuromuscular Nondepolarizing Agents; D010952:Plasma Substitutes
Etude comparative de l'histaminolibération aprés administration de produits anesthésiques de curarisants et de substituts du plasma chez l'homme.