Heparin cofactor activity and antithrombin III concentration in plasma related to age and sex.
Heparin cofactor activity and antithrombin III (At-III) concentration were measured in plasma from 219 healthy men and 177 women. Narrow ranges for heparin cofactor activity and At-III concentration were found. The standard deviation for heparin cofactor activity in men and women was 8.6 and 10.1, respectively, for At-III concentration 10.4 and 12.5. In men, mean heparin cofactor activity and mean At-III concentration decreased significantly with increasing age. In women, mean heparin cofactor activity and mean At-III concentration tended to be lower in fertile age. Hereditary At-III deficiency was detected in one individual.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000510:Alpha-Globulins / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D000991:Antithrombins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
D000510:Alpha-Globulins; D000991:Antithrombins; D000990:Antithrombin III