Characterization of antibodies to the structural polypeptides of HGSAg: evidence for subtype-specific determinants.
Antisera prepared in guinea pigs to the structural polypeptides of HBAAg/adw and HBSAg/ayw were examined by a modified passive hemagglutination assay for antibodies to the subtype-specific d and y determinants. All of the isolated polypeptide fractions stimulated antibodies to both group specific and subtype-specific antigens of the native HBSAg particle from which they were derived. These data indicate that the polypeptides have similarities in their immunochemical structure.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002353:Carrier State / Q000276:immunology; D000939:Epitopes; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D006514:Hepatitis B Surface Antigens; D010455:Peptides