title: Immunological abnormalities in patients who had the oculomucocutaneous syndrome associated with practolol therapy.
abstract: Patients with and without adverse reactions on practolol therapy showed altered immune responses. There was cutaneous anergy to Candida albicans and streptokinase/streptodornase antigens and depression of lymphocyte function in vitro. Anticomplementary activity and a wide range of autoantibodies were found in patients who had received practolol.
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000302:isolation & purification*; D001327:Autoimmune Diseases / Q000175:diagnosis; D003327:Coronary Disease / Q000188:drug therapy; D003875:Drug Eruptions / Q000150:complications / Q000276:immunology*; D005128:Eye Diseases / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011217:Practolol / Q000009:adverse effects* / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D001323:Autoantibodies; D011217:Practolol