The influence of myoneural blockers on intracranial dynamics.
A series of animals was studied to evaluate the effect of commonly used myoneural blockers (curare, succinylcholine, gallamine, and pancuronium) on intracranial physical dynamics. Of this group, only curare alters intracranial pressure. Histamine release secondary to curare administration results in bronchoconstriction with subsequent major alterations in pulmonary ventilation. Resultant hypercarbia along with a decreased cerebral vascular resistance affects intracranial dynamics by alterations in cerebral blood flow; changes in CSF flow patterns passively reflect the alterations in intracranial pressure. These changes can be blocked by prior treatment with antihistamines.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000502:physiology; D003472:Curare / Q000494:pharmacology; D004285:Dogs; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D007427:Intracranial Pressure / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology
D009466:Neuromuscular Blocking Agents; D002245:Carbon Dioxide; D003472:Curare; D013390:Succinylcholine; D010197:Pancuronium; D005703:Gallamine Triethiodide