In-vitro monitoring of cell-mediated immunity to dinitrochlorobenzene.
A dinitrochlorobenzene (D.N.C.B.)/red-blood-cell conjugate inhibited migration of leucocytes which came from D.N.C.B. sensitised patients. This effect provided the basis for a rapid, sensitive, and quantitative in-vitro measure of D.N.C.B. sensitivity. Frequent serial measurement of cell-mediated immunity was possible with the test, provided D.N.C.B. sensitivity was maintained by occasional skin patch tests.
D002464:Cell Migration Inhibition; D004137:Dinitrochlorobenzene / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology; D009578:Nitrobenzenes / Q000276:immunology*; D010328:Patch Tests; D013997:Time Factors
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes