Value of immune-complex assays in diagnosis and management.
Two complement-dependent assays for circulating immune complexes, the C1q-binding assay and the conglutinin binding, were used to study patients with suspected immune-complex disease. Complexes were detected most frequently in multisystem disease such as infective endocarditis (69%) and systemic lupus erythematosus (60%), and less frequently in isolated nephritis (26% of membrano-proliferative nephritis). Sequential estimations in 32 patients showed that concentrations of circulating immune complexes correlated with disease activity and were useful in monitoring therapy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D001666:Binding Sites, Antibody; D003172:Complement C1 / Q000032:analysis*; D003168:Complement Fixation Tests / Q000379:methods*; D004698:Endocarditis, Subacute Bacterial / Q000175:diagnosis; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis; D007105:Immune Complex Diseases / Q000175:diagnosis*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000175:diagnosis; D014657:Vasculitis / Q000175:diagnosis
D000936:Antigen-Antibody Complex; D003172:Complement C1