Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to  alloreactive parental T cells.
The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T-cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients.
D000818:Animals; D001666:Binding Sites, Antibody; D000939:Epitopes; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology*; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D006824:Hybridization, Genetic; D007111:Immunity, Cellular / Q000528:radiation effects; D017710:Lymphocyte Transfusion; D008297:Male; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D000939:Epitopes; D006649:Histocompatibility Antigens