title: Orcein-positive liver deposits in Indian childhood cirrhosis.
abstract: A striking, previously unreported pattern of orcein-positive deposits attributed to excess copper-binding protein was found in liver-biopsy specimens from twelve cases of Indian childhood cirrhosis. A comparable picture was found only in biopsy specimens from patients with Wilson's disease. Deposits seen in about 20% of the two hundred and seventy-nine cases in various control groups, which were associated with prolonged cholestasis, were slight in comparison. This finding could have important therapeutic and pathogenic implications.
mesh_terms: D002648:Child; D002675:Child, Preschool; D004396:Coloring Agents; D003300:Copper / Q000032:analysis* / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000032:analysis*; D006801:Humans; D002479:Inclusion Bodies / Q000032:analysis*; D007194:India / Q000208:ethnology; D007223:Infant; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000209:etiology / Q000473:pathology*; D008131:London; D010078:Oxazines; D011485:Protein Binding; D013194:Staining and Labeling / Q000379:methods
chemical_list: D004396:Coloring Agents; D010078:Oxazines; C002313:PAcein; D003300:Copper