[In vitro and inhibition of anaphylactic reactions 1-methyl-3-isobutylxanthine].
1-methyl-3-isobutylxanthine (MIBX), a potent antiphosphodiesterase drug, inhibited the anaphylactic reactions both in vitro and in vivo: anaphylactic histamine release from the isolated mast cells of rats, anaphylactic contracture of the isolated trachea of guinea pigs, passive cutaneous anaphylaxis (PCA) in mice and anaphylactic bronchial constriction (ABC) in guinea pigs. MIBX inhibited the anaphylactic reaction of the trachea, PCA and ABC more than the corresponding reactions induced by histamine.
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D006636:Histamine Release / Q000187:drug effects; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D014970:Xanthines / Q000494:pharmacology / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D014970:Xanthines; D006632:Histamine
Tormozhenie in vitro i in vivo anafilakticheskikh reaktsiĭ 1-metil-3-izobutilksantinom