NE1: a new neutrophil specific antigen.
The sera of three children with chronic benign neutropenia, due to anti-neutrophil antibodies, were studied with respect to their antibody specificity. This was done by screening the sera against a panel of leukocyte donors in the EDTA micro-agglutination test and in the indirect fluorescence test. Two of the sera contained antibodies against the known neutrophil-specific antigen NA2. The third serum was directed against a new neutrophil-specific antigen. Genetic analysis showed no correlation between this antigen and the already known neutrophil-specific antigens: 9A, NA1, NA2, NB1, and NC1. In the Dutch population the frequency of the new antigen, tentatively called NE1, is 23%, which gives a gene frequency of 0.12.
D000372:Agglutination Tests; D000380:Agranulocytosis / Q000276:immunology*; D000918:Antibody Specificity; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D005787:Gene Frequency; D006801:Humans; D007223:Infant; D009503:Neutropenia / Q000235:genetics / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*
D000939:Epitopes