[Serum concentrations of alpha-1-fetoprotein suggestive of, or pathognomonic for hepatoma (author's transl)].
A short review of alpha-1-fetoprotein (AFP), is followed by a presentation of the serum AFP concentrations obtained in healthy subjects and in patients with hepatoma, cirrhosis of the liver or metastatic liver cancer, measured by radioimmunoassay (RIA). A calculation is made from these results of the upper limit of normal (9 ng/ml), a limit which is suggestive of hepatoma (215 ng/ml) and a limit which is pathognomonic for hepatoma (7500 ng/ml). It is concluded that the quantitative determination of AFP by RIA represents a sensitive method which provides valuable clinical information for the early diagnosis of hepatoma.
D006528:Carcinoma, Hepatocellular / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood*; D009362:Neoplasm Metastasis; D011863:Radioimmunoassay; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins
Hepatom-suspekte und -pathognomonische Serumkonzentrationen von alpha-1-Fetoprotein.