CEA-like antigens in different histologic types of human lung carcinoma.
Comparative studies on the presence and immunological reactivity of CEA and CEA-like antigens in lung and digestive tract cancers were performed. Specific goat and rabbit anti-CEA immune sera were used. Immunofluorescence studies revealed in histologically different types of the lung carcinomas the presence of the cross reacting antigen with classical CEA. Absorption procedures, and double diffusion tests have shown the existence of two at least antigenic determinants in CEA molecule: 1. the determinant specific for the lower parts of the digestive tract cancers not found in the lung carcinomas, and 2. the determinant common for the lung, and the digestive tract cancers.
D000230:Adenocarcinoma / Q000276:immunology; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes; D005770:Gastrointestinal Neoplasms / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000276:immunology; D012509:Sarcoma / Q000276:immunology
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D000939:Epitopes