Adjuvanticity (immunity-inducing property) of cord factor in mice and rats.
Cord factor, a glycolipid in mycobacteria, was found to make a tolerogenic protein antigen immunogenic when injected 0 to 2 days before tolerogen injection in mice and rats. Cord factor was also found to increase phagocytic function of the reticuloendothelial system of mice, and the relationship between the immunity-inducing capacity and the phagocytic function is discussed.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002417:Cattle / Q000276:immunology; D003311:Cord Factors / Q000494:pharmacology*; D005260:Female; D006017:Glycolipids / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D012882:Skin Tests; D005719:gamma-Globulins
D000276:Adjuvants, Immunologic; D003311:Cord Factors; D006017:Glycolipids; D005719:gamma-Globulins