[Electron microscopic structure of the mycelium of Actinomyces chrysomallus, the producer of the antibiotic chrysomallin, during the stab fermentation process].
Ultrastructural changes in the mycelium of Actinomyces (Streptomyces) chrysomallus 2703 producing the antibiotic chrysomallin in the process of submerged fermentation are described. When the antibiotic was produced at a high rate, most hyphae remained viable for a long period of time and had the ultrastructure typical of the young cells of actinomycetes. At the same time, a number of degenerative changes due to aging were observed; these resulted in autolysis. A decrease in the antibiotic titre was accompanied with intensive sporulation in a considerable number of the submerged hyphae. Structural changes in the sporeforming hyphae distinctly differed from those in the vegetative ones: the cell walls became thicker and numerous septa were formed. The exogenous formation of submerged spores in the culture under study has been studied in detail for the first time.
D003470:Culture Media; D003609:Dactinomycin / Q000096:biosynthesis*; D008854:Microscopy, Electron; D013171:Spores, Bacterial / Q000648:ultrastructure; D013302:Streptomyces / Q000378:metabolism / Q000648:ultrastructure*; D013997:Time Factors
D003470:Culture Media; D003609:Dactinomycin
Elektronno-mikroskopicheskoe stroenie mitseliia Actinomyces chrysomallus--produtsenta antibiotika khrizomallina v protsesse glubinnoĭ fermentatsii.