[Development of follicular and parafollicular adenomas in the thyroid of rats treated with thiamazole (author's transl)].
Hypothyroidism is induced in rats treated with thiamazole, an antithyroid drug. If this phase lasts long enough, the follicular cells develop adenomas. Within the same period, the number of parafollicular or C cells increases threefold on an average, but without producing corresponding adenomas, the formation of which is inhibited. When treatment is stopped, a second phase appears during which thyroid function reverts to normal. The previously observed inhibition disappears, and, after a period of latency, the hyperplastic C cells develop parafollicular adenomas. The type of tumors to be found in treated rats (either of them, or both simultaneously) is determined by respective durations of the two phases. The endocrine mechanisms of these phenomena are discussed.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D013956:Antithyroid Agents / Q000506:poisoning*; D007037:Hypothyroidism / Q000139:chemically induced; D008297:Male; D008713:Methimazole / Q000506:poisoning*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D013956:Antithyroid Agents; D008713:Methimazole
Les adénomes à cellules folliculaires et parafolliculaires de la thyroïde du rat soumis au thiamazole.