The use of Midodrin in the treatment of ejaculation disorders following retroperitoneal lymphadenectomy.
The long-term treatment of retrograde ejaculation disorders following retroperitoneal lymphadenectomy with the alpha-sympathomimetic, Midodrin, administered orally, led to improvements in the intensity of orgasm and the degree of erection. Normal ejaculation was induced in 7 out of 12 patients and emission of spermatozoa into the posterior urethra was restored in 3 out of 12 patients by a single intravenous injection of 25--30 mg Midodrin.
D000328:Adult; D001011:Aorta; D004542:Ejaculation / Q000187:drug effects*; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007083:Iliac Artery; D008197:Lymph Node Excision / Q000009:adverse effects*; D008297:Male; D008879:Midodrine / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy / Q000209:etiology; D013094:Spermatozoa / Q000187:drug effects
D004983:Ethanolamines; D008879:Midodrine