title: The effect of endotoxin on the mast cell c'AMP system.
abstract: To determine whether the endotoxin induced release of histamine is mediated via the mast cell c'AMP system, hamster mast cells were isolated and incubated (prior to endotoxin-serum stimulates (ET-S) with disodium cromoglycate, isoproterenol and aminophylline. All drugs caused significant inhibition of the ET-S histamine release. The authors conclude that ET-S utilizes the c'AMP system to release histamine.
mesh_terms: D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D006224:Cricetinae; D004205:Cromolyn Sodium; D000242:Cyclic AMP / Q000378:metabolism*; D004731:Endotoxins / Q000494:pharmacology*; D006636:Histamine Release; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008407:Mast Cells / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology
chemical_list: D004731:Endotoxins; D000628:Aminophylline; D001285:Atropine; D000242:Cyclic AMP; D007545:Isoproterenol; D004205:Cromolyn Sodium; D010646:Phentolamine