Inhibition of absorption capacity of HLA antigens on in vitro hormone-treated lymphocytes.
Hydrocortisone, Agostilben, Agovirin, Neolutin and Superanabolon partially to completely inhibit the absorption capacity of HLA antigens on the lymphocytes in vitro. The effect is directly proportional to the duration of lymphocyte treatment and the type of hormone, yet unrelated to the type of antigen. The importance of this phenomenon for HLA antigen typing in hormones-treated patients is discussed.
D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004054:Diethylstilbestrol / Q000494:pharmacology; D006680:HLA Antigens; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D006908:Hydroxyprogesterones / Q000494:pharmacology; D007518:Isoantibodies; D008214:Lymphocytes / Q000187:drug effects*; D009277:Nandrolone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
D006680:HLA Antigens; D006728:Hormones; D006908:Hydroxyprogesterones; D007518:Isoantibodies; D013739:Testosterone; D009277:Nandrolone; D004054:Diethylstilbestrol; D006854:Hydrocortisone