title: Specificity of human cytotoxic responses to chemically modified autologous cells.
abstract: Human PBML can generate cytotoxic responses to autologous cells that have been chemically modified with TNP or DNP. The cytotoxic effectors have precise hapten specificity. The DNP-specific effectors recognize DNP in association with cell surface alloantigens, which appear to be at least partially associated with HLA-A and -B. The TNP-specific effectors recognize TNP in association with several classes of determinants--some of which are HLA-linked alloantigens that are incompletely associated with HLA-A and -B, while other determinants are widely shared among humans.
mesh_terms: D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D004136:Dinitrobenzenes / Q000276:immunology; D000939:Epitopes; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
chemical_list: D004136:Dinitrobenzenes; D000939:Epitopes; D006680:HLA Antigens; D014301:Trinitrobenzenes