title: The concentration of doxycycline in human prostate gland and its role in the treatment of prostatitis.
abstract: The concentrations of doxycycline were measured in 36 enucleated, enlarged prostate glands. After administration of 200 mg of doxycycline intravenously significant tissue concentrations (mean value 1.79 mug/g) were rapidly obtained. The mean concentration of the drug 14 hours after a repeated oral dose of 100 mg was 1.56 mug/g. The ratios of tissue and serum concentrations were 0.610 and 0.568, respectively. As there are only a few antibiotics which penetrate into the prostate, the importance of these data for the treatment of bacterial or mycoplasma prostatitis is obvious.
mesh_terms: D000284:Administration, Oral; D004318:Doxycycline / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D011472:Prostatitis / Q000188:drug therapy*
chemical_list: D004318:Doxycycline