[The effect of a synthetic anticholinergic agent, N-methyl hyoscine methyl sulfate, on the exocrine pancreatic secretion of the alert dog].
The inhibitory action of N-methyl hyoscine methyl sulphate (N-methyl scopolamine, an anticholinergic drug) has been studied on the exocrine pancreatic secretion stimulated by secretin + caerulein on the conscious dog provided with Thomas cannulae. The dose-response curve shows an "all or nothing" effect on protein secretion since 0.38 microgram/kg. The inhibition of water and bicarbonate secretion is only observed from 12 micrograms/kg. The inhibitory effect of this drug was much greater than that obtained with similar molar quantities of atropine and no central effect has been observed.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012602:Scopolamine Derivatives / Q000494:pharmacology*
D001639:Bicarbonates; D011506:Proteins; D012602:Scopolamine Derivatives
Action d'un anticholinergique de synthése, le méthyl sulfate de N-méthyl hyoscine sur la sécrétion pancréatique exocrine du chien éveillé.