Immunoassay of macrophage stimulating alpha 2 SB (surface binding) glycoprotein in pig plasma following missile trauma.
Pigs were subjected to a standardized missile trauma in the thigh and plasma samples were collected at various times after trauma. The plasma level of an opsonic alpha 2 SB (surface binding) glycoprotein related to macrophage phagocytosis was determined by an agglutination assay using 125I-labelled gelatin particles. The results indicated a transient but significance decrease (p less than 0.01) in the plasma agglutination activity after trauma reflecting a deficiency in plasma alpha 2 SB glycoprotein. One non-surviving animal showed a persistent decrease in the plasma level of alpha 2 SB glycoprotein, while the surviving animals showed a normalization indicating that this agglutination assay may have prognostic value during the course of posttraumatic therapy.
D000372:Agglutination Tests; D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000502:physiology*; D010587:Phagocytosis; D013552:Swine; D013848:Thigh / Q000293:injuries; D014948:Wounds, Gunshot / Q000097:blood* / Q000276:immunology; D000511:alpha-Macroglobulins / Q000032:analysis
D000511:alpha-Macroglobulins