title: Adenoid cystic carcinoma of minor salivary gland. Histochemical and electron microscopic studies of cystlike space.
abstract: Five cases of adenoid cystic carcinoma of minor salivary glands were studied. The mucoid material in the characteristic cystlike space of this neoplasm was distaseresistant periodic acid-Schiff (PAS)--positive, alcain blue-positive, toluidine blue-positive, and mucicarmine-positive. Verhoeff-Van Gieson's method and Weighert's method did not reveal elastic tissue in the cystlike spaces. Mallory's method revealed that a central core in cystlike spaces was similar in stainability to collagen. Wilder's method did not reveal reticular fibers in these spaces. Electron microscopy revealed three readily recognizable zones: a juxtacellular zone of a network of replicated basal lamina, and intermediate zone of stellate granules of mucoid material, and a central core of densely packed aperiodic filaments or collagen fibrils. The histogenesis of cystlike spaces and their realtionship with biologic behaviors of the neoplasm were discussed.
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000032:analysis / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000648:ultrastructure; D003239:Connective Tissue Cells; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004547:Elastic Tissue / Q000032:analysis; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D009093:Mucus / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D013194:Staining and Labeling
chemical_list: D003094:Collagen