Specificity of the Tumor-specific transplantation antigen induced by JC virus, a human polyomavirus.
The specificity of the tumor-specific transplantation antigen (TSTA) induced by JC virus was investigated by cross protection tests in weanling hamsters. Hamsters immunized with JC virus, BK virus, or SV40 were challenged 5 weeks later with known numbers of JC virus- or SV40-induced hamster tumor cells. Both the JC virus-immune and the SV40-immune hamsters showed resistance to challenge with homologous but not heterologous tumor cells, and the BK virus-immune hamsters were not resistant to either heterologous tumor cell. The TSTA induced by JC virus did not cross-react with that induced by SV40.
D000818:Animals; D001739:BK Virus / Q000276:immunology; D006224:Cricetinae; D003429:Cross Reactions; D046508:Culture Techniques; D000939:Epitopes; D006649:Histocompatibility Antigens / Q000008:administration & dosage; D006801:Humans; D007114:Immunization; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000517:prevention & control; D027383:Papillomaviridae / Q000276:immunology*; D027382:Polyomaviridae; D013539:Simian virus 40 / Q000276:immunology
D000939:Epitopes; D006649:Histocompatibility Antigens