[Immunological importance of a new protein: the beta2-microglobulin (author's transl)].
The Authors are presenting a concise review on a protein, beta2-microglobulin, that has gained in notable importance in the immunological field during these last years. The story of this protein begins with nephrology because it has a notable importance in the diagnosis of renal tubular diseases; in fact its presence in the electrophoretic pattern of proteinuria puts in evidence renal tubular damage. Nextly immunological studies have shown the beta2-microglobulin has strict correlations with the HL-A system; probably it forms a part of this system, as shown by the new immunofluorescent methods applied to the lymphocte. A recent study has shown also the beta2-microglobulin serum levels are very high in some malignant diseases, like in acute leukemia; however this low molecular weight protein could also be the expression of malignancy because it can be a product of non mature cells in a large quantity.
D000328:Adult; D000361:Agammaglobulinemia / Q000276:immunology; D000917:Antibody Formation; D001609:Beta-Globulins / Q000302:isolation & purification*; D002648:Child; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens; D006801:Humans; D007938:Leukemia / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D011507:Proteinuria / Q000276:immunology; D001613:beta 2-Microglobulin / Q000302:isolation & purification*
D001609:Beta-Globulins; D006680:HLA Antigens; D001613:beta 2-Microglobulin
Importanza immunologica di una nuova proteina: la beta2-microglobulina