Hyperinsulinism, diabetes mellitus, and respiratory distress of the newborn: A common link?
Hyperinsulinism may reduce glycerol-3-phosphate and dihydroxyacetone phosphate production and thus impair phospholipid synthesis and surfactant production in the lung. This mechanism could be responsible for the increased incidence of respiratory-distress syndrome in the infants of diabetic mothers.
D004099:Dihydroxyacetone Phosphate / Q000172:deficiency; D005260:Female; D005333:Fetus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005994:Glycerophosphates / Q000172:deficiency; D006019:Glycolysis; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007231:Infant, Newborn; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008431:Maternal-Fetal Exchange; D010743:Phospholipids / Q000096:biosynthesis; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000096:biosynthesis; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology*
D005994:Glycerophosphates; D007328:Insulin; D010743:Phospholipids; D011663:Pulmonary Surfactants; D004099:Dihydroxyacetone Phosphate; D005947:Glucose