title: Effect of radiotherapy on the neutrophil and the lymphocyte enzymatic equipment and serum immunoglobulins in patients with cancer of the larynx.
abstract: In 30 patients with cancer of the larynx, aged 40 to 70 years, treated by radiotherapy 6 to 9 years ago the decreased activity of neutrophil beta-glucuronidase and N-acetyl-beta-glucosaminidase accompanied by a decrease of absolute count of enzyme-positive cells was noted. Numbers of acid phosphatase-positive neutrophils were also decreased. Moderate increase of the neutrophil alkaline phosphatase activity and of numbers of enzyme-positive cells was another observed feature. The main finding in lymphocytes of the patients consisted in the appearance of cells exhibiting diffusion of lysosomal enzymes, especially of beta-glucuronidase, N-acetyl-beta-glucosaminidase and to a lesser degree of acid phosphatase into the cell cytoplasm. Moderate increase of immunoglobulin level, especially that of IgA, reflected probably the immunologic mobilization of patients.
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D005966:Glucuronidase / Q000097:blood; D006596:Hexosaminidases / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008214:Lymphocytes / Q000201:enzymology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology* / Q000528:radiation effects; D009195:Peroxidase / Q000097:blood
chemical_list: D007136:Immunoglobulins; D009195:Peroxidase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D006596:Hexosaminidases; D005966:Glucuronidase