Coexistence of helper and suppressor activities in carrier-primed spleen cells.
Both helper and suppressor activities for an in vitro IgG anti-hapten (Lac) response to Lac-HRBC were demonstrated in the same population of carrier (HRBC)-primed spleen cells. The relative radiosensitivity of suppressor activity permitted the selective removal of suppression and the demonstration of help. Both activities appear to be T cell-dependent and antigen-specific. Dilution analysis showed that help and suppression are mediated by distinct populations of cells.
D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002469:Cell Separation; D002645:Chickens; D003165:Complement System Proteins; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D006433:Hemocyanins / Q000276:immunology; D006736:Horses; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D051379:Mice; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D000939:Epitopes; D003165:Complement System Proteins; D006433:Hemocyanins