Raised urinary fibrin-degradation products, complement, and IgG during an influenza-like illness.
Urine from eight normal controls in whom an influenza-like illness developed contained high concentrations of fibrin-degradation products (F.D.P.), IgG, and C3. The study was carried out when influenza A was prevalent in the community. However, a wide range of serological investigations revealed no evidence for influenza A or other viruses. The infection may have been caused by other viruses which produce upper-respiratory-tract infections and which are not readily diagnosed by serology. Urinary fibrin-degradation products are a well-known marker of glomerulonephritic activity and viral antigens may have induced an immune-complex glomerulonephritis in the 8 controls in whom an influenza-like disease developed. A larger normal population should be investigated during a virus epidemic.
D002940:Circadian Rhythm; D003176:Complement C3 / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine*; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology / Q000652:urine; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology / Q000652:urine; D007074:Immunoglobulin G / Q000652:urine*; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000652:urine*; D011507:Proteinuria / Q000652:urine; D014777:Virus Diseases / Q000150:complications / Q000276:immunology / Q000652:urine*
D003176:Complement C3; D005338:Fibrin Fibrinogen Degradation Products; D007074:Immunoglobulin G; D003165:Complement System Proteins