Accelerated growth of mammary tumor cells in normal and athymic mice after treatment in vitro with dexamethasone.
The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in athymic mice suggests that T-lymphocyte-mediated  immunity was not a factor in the accelerated progression in vivo of the tumor cells that had been cultured in the presence of dexamethasone.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology; D000818:Animals; D002460:Cell Line; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D007109:Immunity / Q000187:drug effects; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology; D008324:Mammary Tumor Virus, Mouse / Q000201:enzymology; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014412:Tumor Virus Infections / Q000188:drug therapy*
D003907:Dexamethasone; D012194:RNA-Directed DNA Polymerase