Hyponatraemic hypertensive syndrome with renal-artery occlusion corrected by captopril.
Malignant hypertension with severe hyponatraemia, hypokalaemia, depletion of sodium and potassium, and elevated blood levels of renin, angiotensin I, angiotensin II, aldosterone, and arginine vasopressin developed in a woman with renal-artery occlusion. Plasma angiotensin II was disproportionately high in relation to exchangeable sodium. Captopril, by inhibiting conversion of angiotensin I to angiotensin II, further elevated the blood levels of renin and angiotensin I but corrected all other abnormalities. Unilateral nephrectomy was subsequently curative.
D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000097:blood; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy*; D007010:Hyponatremia / Q000188:drug therapy*; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011392:Proline / Q000031:analogs & derivatives*; D012078:Renal Artery Obstruction / Q000503:physiopathology*; D012083:Renin / Q000097:blood; D013577:Syndrome
D000804:Angiotensin II; D001127:Arginine Vasopressin; D000450:Aldosterone; D000803:Angiotensin I; D011392:Proline; D002216:Captopril; D012083:Renin; D011188:Potassium