title: The effect of isoproterenol on hypoxia-mediated histamine release.
abstract: In 13 guinea pigs the pulmonary circulation was isolated from the systemic circulation and perfused with Tris buffer alone or with isoproterenol. The lungs were initially ventilated with 100% O2 and then switched to 100% N2 to induce alveolar hypoxia. The effluent was collected from the aorta and assayed for histamine. In the control group (n = 7) the histamine levels rose markedly with hypoxia. In the group perfused with Tris buffer and isoproterenol (n = 6) the rise in histamine levels was markedly diminished. Therefore, the authors conclude that isoproterenol, in their in vivo model, had a dramatic effect on hypoxia (non-immunologic) mediated histamine release.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects*; D000860:Hypoxia / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D009584:Nitrogen; D010100:Oxygen
chemical_list: D006632:Histamine; D007545:Isoproterenol; D009584:Nitrogen; D010100:Oxygen