Inhibition of gastric acid and gastrin secretion by somatostatin in man.
Somatostatin inhibited gastric acid secretion significantly in three ZE patients, while serum gastrin was lowered only in two. A direct inhibition of pentagastrin-stimulated acid secretion by somatostatin was demonstrated in three healthy volunteers and four patients with duodenal ulcer disease. Somatostatin reduced betazole-stimulated gastric acid secretion to a lesser degree. The immunohistological demonstration of somatostatin-producing cells apposite to antral G-cells suggest a physiological role of somatostatin in the regulation of gastrin secretion in man.
D000293:Adolescent; D000328:Adult; D000906:Antibodies; D000917:Antibody Formation; D000941:Antigens; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000276:immunology; D008297:Male; D013004:Somatostatin / Q000096:biosynthesis / Q000276:immunology / Q000494:pharmacology*; D015043:Zollinger-Ellison Syndrome / Q000503:physiopathology
D000906:Antibodies; D000941:Antigens; D005755:Gastrins; D007328:Insulin; D013004:Somatostatin