Mast cells and tumor angiogenesis.
Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2-3 days after implantation. A 40-fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague-Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D005321:Extraembryonic Membranes / Q000187:drug effects*; D006133:Growth Substances / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000209:etiology*; D051381:Rats; D012972:Sodium Hydroxide / Q000494:pharmacology; D013194:Staining and Labeling; D013997:Time Factors
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances; D012972:Sodium Hydroxide