[Studies on the significance of antigen in the 6-mercapopurine-influenced humoral antibody response in guinea pigs].
The mechanism of suppression of humoral immune response to dinitrophenylated bovine gamma globulin (DNP23-BGG), human serum albumin (HSA), and trinitrophenylated sheep red blood cells (TNP-SRBC) by 6-mercaptopurine (6-MP) was studied in guinea pigs. Following the intradermal application of the antigens emulsified in complete (CFA) or incomplete Freund's adjuvant (IFA) each test animal was given 6-MP, 10 mg/kg/day for 7 days. This treatment resulted in a significant suppression of the anti BGG and anti SRBC agglutinating and complement binding antibody production. The latter was only significantly suppressed if the TNP-SRBC were applied together with CFA and not if TNP-SRBC were given in IFA. The anti DNP and anti HSA antibody formation was not influenced.
D000371:Agglutination / Q000187:drug effects; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody / Q000187:drug effects; D002417:Cattle; D000939:Epitopes; D005620:Freund's Adjuvant / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D015122:Mercaptopurine / Q000494:pharmacology*; D012709:Serum Albumin / Q000494:pharmacology; D012756:Sheep
D000939:Epitopes; D012709:Serum Albumin; D005620:Freund's Adjuvant; D015122:Mercaptopurine
Untersuchungen über die Bedeutung des Antigens bei der durch 6-Merkaptopurin beeinflussten humoralen Immunantwort des Meerschweinchens