title: [Evaluation of the results of treatment of Graves' disease by synthetic antithyroid drugs].
abstract: A study of 43 case records of Grave's disease followed up for at least two years after stopping treatment with synthetic antithyroid drugs, revealed 7 patients who did not relapse, 12 cases of rebound, (less than six months after stopping treatment), and 21 cases of recurrence (more than six months) of 10 cases (23%) had several recurrences. In relation to the 87 patients who formed this series, the cure rate after a single acute attack was only 50%. The good tolerance of antithyroid drugs, their almost complete efficacy, (2 failures out of 87 patients), indicate however that for a first attack they should be given for at least 18 months. Rebounds and recurrences suggest that radical treatment, mainly surgery, still have their place.
mesh_terms: D000293:Adolescent; D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use*; D002231:Carbimazole / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006111:Graves Disease / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008779:Methylthiouracil / Q000627:therapeutic use; D008875:Middle Aged; D012008:Recurrence; D012075:Remission, Spontaneous
chemical_list: D013956:Antithyroid Agents; D002231:Carbimazole; D008779:Methylthiouracil
vernacular_title: Evaluation des résultats du traitement de la maladie de Basedow par les anti-thyroïdiens de synthèse.