Cell cycle dependent response and combined treatment of tumor.
Attempt was made to summarize data indicating cell cycle dependence of survival response to various antitumor agents. Normalized patterns of survival response permitted us to group agents into two major categories. It was known that effect of agents on cell progression was not only related to respective periods of the cell cycle but also rather specific for each category of agents. The extent of progression inhibition was not compared on a quantitative basis. On the basis of above findings a rational combination and a scheduled administration of agents for effective sterilization of tumor cells were considered.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001761:Bleomycin / Q000008:administration & dosage; D002453:Cell Cycle / Q000187:drug effects* / Q000528:radiation effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008937:Mitomycins / Q000008:administration & dosage; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012107:Research Design
D000970:Antineoplastic Agents; D008937:Mitomycins; D001761:Bleomycin