Ultrastrutural studies of vascular and muscular changes in ascorbic acid deficient guinea-pigs.
Disorganization of muscle structures such as fragmentation of myofilaments with a loss of contrast in the Z bands, swelling of mitochondria and glycogenic infiltration, was seen in ascorbic acid deficient guinea-pigs. Vacuolar degeneration of external and internal endothelial cell membranes with accompanying dystrophic changes of the surrounding muscle and lack of collagen formation were consistent findings. Chondroblasts showed a marked dissolution of the matrix vesicle and a lack of hyaline droplets.
D000818:Animals; D001206:Ascorbic Acid Deficiency / Q000473:pathology*; D001808:Blood Vessels / Q000648:ultrastructure*; D002196:Capillaries / Q000648:ultrastructure; D002356:Cartilage / Q000648:ultrastructure; D003094:Collagen; D004727:Endothelium / Q000648:ultrastructure; D005260:Female; D006168:Guinea Pigs; D006651:Histocytochemistry; D006818:Hyalin; D008297:Male; D009132:Muscles / Q000648:ultrastructure*
D003094:Collagen