Investigations on the efficacy of two schemes of standard gammaglobulin administration in the prevention of viral hepatitis.
Prophylactic administration of standard gammaglobulin (G) to over 5,000 children led to a more than 6-fold decrease in the incidence of icteric viral hepatitis (V.H.) as compared with the control group and to the disappearance of the autumn--winter epidemic peak. A 3-fold decrease in the incidence of subclinical forms was also achieved. In another group of 5,000 children G was only given to contacts in epidemic foci; the incidence of icteric V. H. was similar to that recorded in controls, while subclinical forms were 2 times more frequent in children having received G after the infectant contact.
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D012383:Romania; D012621:Seasons; D005719:gamma-Globulins / Q000008:administration & dosage*
D006514:Hepatitis B Surface Antigens; D005719:gamma-Globulins; D000410:Alanine Transaminase