Aluminium hydroxide in bile-salt diarrhoea.
The treatment of choleraic diarrhoea remains a problem. Cholestyramine is effective but long-term treatment is often impracticable. In-vitro studies have shown that aluminium hydroxide has bile-acid-binding properties comparable with those of cholestyramine. The bile-acid-binding properties of aluminium hydroxide have now been investigated in vivo and applied to the treatment of patients with choleraic diarrhoea. Aluminium hydroxide increased the faecal bile-salt concentration of patients with a normal bowel habit whereas magnesium hydroxide had no effect. Eight patients with severe choleraic diarrhoea were treated with aluminium-hydroxide suspension: bowel motion became less frequent and daily faecal weight fell.
D000328:Adult; D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D001647:Bile Acids and Salts / Q000032:analysis / Q000378:metabolism*; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy; D005243:Feces / Q000032:analysis; D006801:Humans; D008276:Magnesium Hydroxide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013535:Suspensions
D001647:Bile Acids and Salts; D013535:Suspensions; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide