Hypotensive activity of some dihydroxycoumarins and their congeners.
Evaluation of the hypotensive activity of dihydroxy coumarins and their congeners reveal that the naturally occurring dimethoxy coumarin Scoparone has maximal activity, more significant than L-alpha-methyl dopa. Structure activity relationship studies are reported with an attempt to offer a probable mechanism of action.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D001794:Blood Pressure / Q000187:drug effects; D001728:Dicumarol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D008750:Methyldopa / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D008750:Methyldopa; D001728:Dicumarol