Minaxolone: a new water-soluble steroid anaesthetic.
The induction characteristics of minaxolone, a water-soluble steroid anaesthetic, were studied in fit patients undergoing minor urological or gynaecological operations. Minaxolone acted as rapidly as thiopentone. A dose of 0.25 mg kg-1 did not always produce anaesthesia in patients who had not received premedication but 0.5 mg kg-1 was an adequate dose. Excitatory effects were less common with the higher doses of anaesthetic. These effects were usually slight and rarely interfered with the course of anaesthesia. Unlike propanidid, minaxolone did not prolong the duration of action of suxamethonium. Minaxolone is easy to administer and causes little venous damage.
D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D013511:Minor Surgical Procedures; D011278:Pregnanes / Q000494:pharmacology*; D011280:Pregnanolone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D011410:Propanidid / Q000494:pharmacology; D012995:Solubility; D013874:Thiopental / Q000494:pharmacology
D000777:Anesthetics; D011278:Pregnanes; C020413:minaxolone; D011410:Propanidid; D011280:Pregnanolone; D013874:Thiopental