Inhibition of sebum excretion by an H2 blocker.
Cimetidine, 1g orally per day, partially inhibited sebum excretion in patients with acne. Whether this was the result of H2-receptor blockade or an antiandrogen action is unknown.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012629:Sebum / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
D006146:Guanidines; D002927:Cimetidine