Evidence for an HLA-linked resistance gene in Buerger's disease.
The incidence of Thromboangiitis Obliterans in brothers and the high prevalence in some ethnic groups have led us to investigate the histocompatibility HLA-A, B and DR antigens of 46 Buerger's disease patients. The main result indicates a marked decreased freqeuncy of the B12 antigen: 2.2% vs 28% in controls. Our study suggests that Buerger's disease is, on the basis of HLA antigens, a distinct immunogenetic entity and not a particular form of arteriosclerosis. Moreover, this disorder may represent a clue to the existence of resistance genes linked to HLA.
D000328:Adult; D000939:Epitopes; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013919:Thromboangiitis Obliterans / Q000235:genetics* / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens