title: Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides.
abstract: Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines. Antibodies to these immunogens were measured and sera were allotyped for several Gm, A2m, and Km antigens. A highly significant association was found between the Km(1) allotype and the immune responses (difference between post-immunisation and pre-immunisation antibody levels) to H. influenzae and meningococcus C polysaccharides in the White children.
mesh_terms: D000907:Antibodies, Bacterial / Q000302:isolation & purification*; D001428:Bacterial Vaccines / Q000276:immunology*; D044383:Black People; D004168:Diphtheria Toxoid / Q000276:immunology; D005802:Genes, MHC Class II; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification*; D007223:Infant; D007519:Isoantigens / Q000235:genetics / Q000276:immunology; D009345:Neisseria meningitidis / Q000276:immunology*; D010567:Pertussis Vaccine / Q000276:immunology; D010641:Phenotype; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D044465:White People
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D007136:Immunoglobulins; D007519:Isoantigens; D010567:Pertussis Vaccine; D011135:Polysaccharides, Bacterial; D013745:Tetanus Toxoid