[Influence of five commercial heparin preparations on the collagen induced platelet aggregation (author's transl)].
The ADP- and collagen-induced aggregation of platelets in PRP of healthy probands was tested in vitro in the presence of 4 heparin preparations (Novo, Vitrum, Liquemin, Haemoderivate) and of a heparinoid (Eleparon). None of the preparations caused a significant direct aggregation. The collagen-induced aggregation was inhibited by all mentioned preparations; thereby the heparins proved to be effective approx. to the same degree whereas the heparinoid proved to be significantly less effective. The ADP-induced aggregation was potentiated by all preparations. A considerably different sensitivity to heparin could be observed in the single PRP's. A special method was found out to exclude the influence of the heparin-sensitivity of the PRP's to compare the special effects of the heparins.
D003094:Collagen / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000145:classification / Q000494:pharmacology*; D006496:Heparinoids / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010974:Platelet Aggregation / Q000187:drug effects*
D006496:Heparinoids; D006493:Heparin; D003094:Collagen
Die Beeinflussung der Kollagen-induzierten Plättchen-Aggregation durch fünf käuflich erhältliche Heparinpräparate.