Inhibition of spontaneous transformation of rat embryo cells releasing endogenous type C virus by virus-specific antiserum.
Noninbred Sprague-Dawley rat embryo cell clones predictably undergo transformation after 20-30 in vitro passages following spontaneous release of endogenous rat leukemia virus (RaLV). In the presence of RaLV-specific antiserum, virus production and infectivity were reduced and transformation was delayed from 6 to 25 weeks. Transformation was not associated with an increased expression of Kirsten murine sarcoma virus-related src gene RNA.
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage*; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D004622:Embryo, Mammalian; D012367:RNA, Viral / Q000378:metabolism; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D051381:Rats; D012190:Retroviridae / Q000201:enzymology / Q000276:immunology*; D009053:Sarcoma Viruses, Murine / Q000378:metabolism; D014779:Virus Replication
D000914:Antibodies, Viral; D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase