[Effect of inductors of alkali cation permeability on cytochrome c bound to mitochondrial membrane].
The effect of inductors of alkali cation permeability--valinomycin, gramicidin A, gramicidin S and its N,N'-diacetyl derivative--on rat liver mitochondria during respiration has been studied. It is shown that valinomycin, gramycidin A and diacetylgramicidin S at optimal concentration for uncoupling cause two-phase activation of mitochondrial respiration and that this effect results from cytochrome c solubilization. Gramicidin S at optimal concentration cannot remove cytochrome c from the respirating mitochondria. It is suggested that this property of gramicidin S is owned to cytochrome c immobilisation in membrane, due to the effect of this compound.
D000818:Animals; D002412:Cations / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006096:Gramicidin / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption; D010539:Permeability; D051381:Rats; D012995:Solubility; D014475:Uncoupling Agents; D014634:Valinomycin / Q000494:pharmacology*
D002412:Cations; D003574:Cytochrome c Group; D014475:Uncoupling Agents; D006096:Gramicidin; D014634:Valinomycin
Deistvie induktorov kationnoĭ pronitsaemosti na sviaz' tsitokhroma c s membranoĭ mitokhondriĭ.