The effect of intravenous injection of ethyl palmitate emulsion on sequestration of thermally damaged erythrocytes in rats with experimentally induced hypersplenism, and in normal rats.
The authors attempted at experimental elimination of sequestration function of the spleen in Wistar rats using an i.v. injection of ethyl palmitate emulsion, both in "hypersplenic" animals being long-term applied i.p. methyl cellulose solution, and in control rats. In the rats clearance of 51Cr-labelled and thermally damaged erythrocytes from blood was examined and their sequestration in the spleen and liver followed. The ethyl palmitate injection resulted in both experimental groups in a significant decrease of the erythrocyte counts sequestrated in the spleen, and significant prolongation of the elimination half time for thermally damaged erythrocytes from the blood.
D000818:Animals; D004905:Erythrocyte Aging / Q000187:drug effects*; D004912:Erythrocytes / Q000502:physiology; D006358:Hot Temperature; D006971:Hypersplenism / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010168:Palmitates / Q000494:pharmacology*; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000502:physiology
D010168:Palmitates; D010169:Palmitic Acids