Immunological properties of ampicillin polymers.
The immunologic effects of ampicillin polymers were studied in mice and rabbits. Polymerized ampicillin--in contrast to monomers--had a suppressive effect on the antibody response to penicilloylated proteins. Unfractionated ampicillin polymer, and high molecular weight fractions were found to have an immunogenic effect in mice, when tested by a haemolytic plaque assay. The immunogenic effect of variously sized polymers did not correspond to their antigenic activity as reflected by passive cutaneous anaphylaxis experiments.
D000667:Ampicillin / Q000276:immunology*; D000917:Antibody Formation; D000941:Antigens; D004306:Dose-Response Relationship, Immunologic; D004903:Erythrocyte Aggregation; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D008970:Molecular Weight; D009211:Myoglobin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D010406:Penicillins / Q000276:immunology*; D011108:Polymers; D012709:Serum Albumin / Q000276:immunology; D005719:gamma-Globulins
D000941:Antigens; D009211:Myoglobin; D010406:Penicillins; D011108:Polymers; D012709:Serum Albumin; D005719:gamma-Globulins; D000667:Ampicillin