title: Microbial secondary metabolites with potential use in cancer treatment. (Plasmid involvement in biosynthesis and compounds.
abstract: Antibiotics and small molecular enzyme inhibitors produced by micro-organisms are microbial secondary metabolites which have no obvious function in the growth of microorganisms. Involvement of plasmids in their biosyntheses has been studied and the structure of the microbial world where various compounds with widely varying structures have been found has been shown to be due to the presence of a great variety of plasmids. On the basis of this structure of microbial world, the author has found the microbial products which have various activities useful in treatment of cancer or in suppression of carcinogenesis. In this paper, the author reviewed his following studies: the plasmid involvement in biosyntheses of bioactive microbial secondary metabolites; the mechanism of therapeutic effect of bleomycin, and the development of useful analogs and derivatives of bleomycin and anthracyclic antibiotics; the screening method to find compounds affecting immune system, and the action of bestatin in enhancing delayed-type hypersensitivity and therapeutic effects of anticancer agents; enzyme inhibitors with potential utility in treatment or prevention of cancer.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000167:Acriflavine / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001761:Bleomycin / Q000378:metabolism / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002701:Chloramphenicol / Q000096:biosynthesis; D002874:Chromosome Mapping; D003300:Copper / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000096:biosynthesis; D005796:Genes; D006689:Hodgkin Disease / Q000188:drug therapy; D007111:Immunity, Cellular / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000276:immunology; D010957:Plasmids / Q000187:drug effects; D012878:Skin Neoplasms / Q000188:drug therapy; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors; D001761:Bleomycin; D000167:Acriflavine; D002701:Chloramphenicol; D003300:Copper; D015105:3',5'-Cyclic-AMP Phosphodiesterases