title: Detection by electron microscope of rod-shaped organisms in synovial membrane from a patient with the arthritis of Whipple's disease.
abstract: Rod-shaped organisms identical to those present in the jejunal mucosa have been found in the synovial membrane of a patient with Whipple's disease. These probably caused inflammatory changes which sere reflected in an increase of the cellular content and high enzyme levels (acid phosphatase and 5-nucleotidase) of the synovial fluid. Tetracycline was effective in controlling the bowel lesion but only had a temporary effect upon the arthritis. Erythromycin controlled both the bowel lesion and the arthritis.
mesh_terms: D001168:Arthritis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D004917:Erythromycin / Q000627:therapeutic use; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013582:Synovial Fluid / Q000032:analysis; D013583:Synovial Membrane / Q000473:pathology; D013752:Tetracycline / Q000627:therapeutic use; D008061:Whipple Disease / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*
chemical_list: D004917:Erythromycin; D013752:Tetracycline