[The effects of gammaglobulins in resistant epilepsies. A preliminary study (author's transl)].
The effect of injections of gammaglobulins 16 Mérieux (1 ml/kg) was studied in 9 patients aged from 1 to 35 years suffering from epilepsy resistant to conventional anticonvulsant treatment. Different types of epilepsy were studied to try to discover a possible indication as a function of the type of epilepsy. Results were assessed according to the patients' behaviour, the frequency and severity of clinical fits, the results of psychological tests, and EEG tracing recorded over long periods of time. Recordings were repeated every 2 to 3 weeks. Favourable results were observed in 7 cases with: --an increased rate of sleeping and waking EEG tracings, --a reduction in the percentage of paroxysms whatever the wakefulness stage, --alterations in the percentages of some sleep stages. The possible mechanisms of action of IgG are discussed.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D008297:Male; D012894:Sleep Stages / Q000187:drug effects; D005719:gamma-Globulins / Q000494:pharmacology / Q000627:therapeutic use*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005719:gamma-Globulins
Effets des gammaglobulines sur des épilepsies rebelles. Etude préliminaire.