Cumulation and elimination of horse-anti-dog lymphocyte and normal horse gammaglobulin in dogs.
Two groups of dogs received daily intravenous doses of 20 mg/kg 131-I-labelled horse-anti-dog lymphocyte globulin or normal horse gammaglobulin respectively over a period of 11 days. Horse-anti-dog lymphocyte globulin showed a significantly higher eleimination rate than normal horse gammaglobulin. In contrary to the continuous increase in serum radioactivity during normal horse gammaglobulin treatment, there was a plateau after the 5th day in the horse-anti-dog lymphocyte globulin group. The xenogeneic protein concentration, measured with the single radial immunodiffusion technique, at the end of treatment was 165 +/- 8 mg/1 in the horse-anti-dog lymphocyte globulin, compared to 498 +/- 15 mg/1 in the normal horse gammaglobulin group. After treatment horse-anti-dog-lymphocyte globulin treated animals showed a significantly higher increase in active hemagglutination titer against horse erythrocytes with an average of 2(-8).
D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D006207:Half-Life; D006736:Horses / Q000276:immunology; D007700:Kinetics; D008297:Male; D005719:gamma-Globulins
D000961:Antilymphocyte Serum; D005719:gamma-Globulins