title: [Drug interactions in cardiovascular therapy].
abstract: Cardiovascular therapy frequently requires simultaneous administration of several drugs. These drugs may interact pharmacokinetically or pharmacodynamically, and most drug interactions are therapeutically useful. The clinical importance of adverse drug interactions is often overestimated; they are almost always predictable and preventable, if their mechanisms are understood and the drug dosages appropriately modified. Coumarin anticoagulants and cardiac glycosides are involved in the most serious interactions. Diuretics, antiarrhythmic drugs, sympatholytics, sympathomimetics and monoamine oxidase blockers also interact in clinically significant fashion with other drugs.
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology; D001692:Biological Transport; D001711:Biotransformation; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D001728:Dicumarol / Q000378:metabolism; D004077:Digoxin / Q000378:metabolism; D004347:Drug Interactions; D006145:Guanethidine / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D011485:Protein Binding; D012709:Serum Albumin
chemical_list: D000928:Antidepressive Agents; D012709:Serum Albumin; D004077:Digoxin; D001728:Dicumarol; D006145:Guanethidine
vernacular_title: Medikamentöse Wechselwirkungen in der kardiovaskulären Therapie