Regional mapping of the HLA on the short arm of chromosome 6.
A detailed gene marker study was performed on a partial 6p trisomic child resulting from a balanced maternal translocation t (2;6) (p 2505; p2105). HLA typing and mixed lymphocyte reaction showed that the breakpoint on chromosome 6 was located within the HLA gene cluster, allowing an accurate location of the D determinants. Localization of the P blood group locus within the region 6 p 2105 to 6 p ter was excluded.
D002478:Cells, Cultured; D002648:Child; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D003165:Complement System Proteins / Q000032:analysis; D000939:Epitopes; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D010375:Pedigree; D014178:Translocation, Genetic; D014314:Trisomy
D000939:Epitopes; D006680:HLA Antigens; D003165:Complement System Proteins