Specificity of the antibody response of rabbits to a self-antigen.
The demonstration that the antigenic determinants on rabbit cytochrome c that elicit antibodies in rabbits occur in regions of variability among mammalian cytochromes c suggests the existence of an evolutionary process which eliminates genetic specificities for self-determinants.
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D005075:Biological Evolution; D003574:Cytochrome c Group / Q000276:immunology*; D000939:Epitopes; D007108:Immune Tolerance; D008297:Male; D010446:Peptide Fragments / Q000276:immunology; D011487:Protein Conformation; D011817:Rabbits; D013045:Species Specificity
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D003574:Cytochrome c Group; D000939:Epitopes; D010446:Peptide Fragments