title: The steering function of T cells in expression of the antibody repertoire directed against multideterminant protein antigen.
abstract: Limitation in the T-cell repertoire has the consequence of reducing the heterogeneity of antibody production. This has been demonstrated in three different systems, in which the T-cell restriction was imposed (1) by tolerance, (2) by peptide priming (3) by natural scarcity. Therefore, expressed repertoires may represent only a portion of the genetically prescribed V regions.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D001717:Birds; D003429:Cross Reactions; D000939:Epitopes; D000882:Haplorhini; D006801:Humans; D007108:Immune Tolerance; D008247:Lysosomes / Q000276:immunology; D010215:Papio; D010455:Peptides / Q000276:immunology; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000939:Epitopes; D010455:Peptides