Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy.
beta-Thromboglobulin levels and platelet-aggregate ratios were determined in blood-samples from healthy control subjects and from diabetic patients with and without microangiopathic complications. Patients with diabetic microangiopathy had significantly elevated beta-thromboglobulin levels and also reversible platelet aggregates. In nine newly treated diabetics blood-glucose control was associated with a significant fall in plasma beta-thromboglobulin. Since beta-thromboglobulin is a platelet-specific protein the results indicate that diabetic microangiopathy is associated with evidence of platelet activation and that this may be influenced by the degree of biochemical control.
D000368:Aged; D001609:Beta-Globulins / Q000032:analysis*; D001792:Blood Platelets; D002196:Capillaries; D003920:Diabetes Mellitus / Q000097:blood / Q000628:therapy; D003925:Diabetic Angiopathies / Q000097:blood* / Q000209:etiology; D003930:Diabetic Retinopathy / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation; D013927:Thrombosis / Q000097:blood* / Q000209:etiology
D001609:Beta-Globulins