Studies on the immunosuppressive effect of organochlorine and organophosphoric pesticides in subacute experiments.
Subacute experiments were carried out on rabbits by daily oral administration of Lindane, Malathion and Dichlorophos. A dose-dependent significant decrease in Salmonella typhi induced immune response was found in sera of animals treated with these pesticides compared to untreated controls. Inihbition of cholinesterase activity confirmed the immunological findings.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D004006:Dichlorvos / Q000494:pharmacology*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012485:Salmonella typhi / Q000276:immunology
D000907:Antibodies, Bacterial; D001556:Hexachlorocyclohexane; D004006:Dichlorvos; D008294:Malathion