Plasma-arginine-vasopressin response to insulin-induced hypoglycaemia.
Insulin-induced hypoglycaemia caused a threefold rise in plasma-arginine-vasopressin concentration (to 4-36 +/- 0-77 pmol/1) in ten subjects who had normal posterior-pituitary function. Plasma-arginine vasopressin reached a peak 30 min after injection of insulin. Plasma concentrations of arginine vasopressin obtained with hypoglycaemia were similar to those achieved after overnight dehydration for 14-16 h. No rise in plasma-arginine-vasopressin was observed in three patients with cranial diabetes insipidus in whom severe hypoglycaemia developed after insulin infusion. It is suggested that the measurement of arginine vasopressin during insulin-induced hypoglycaemia may be a useful clinical test of posterior-pituitary function.
D000293:Adolescent; D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D010904:Pituitary Gland, Posterior / Q000502:physiology* / Q000503:physiopathology; D013997:Time Factors; D014667:Vasopressins / Q000031:analogs & derivatives*
D001786:Blood Glucose; D007328:Insulin; D014667:Vasopressins; D001127:Arginine Vasopressin