Disequilibrium in control of proteolysis as a cause of pre-eclampsia.
The interrelated systems which control proteolysis may go into disequilibrium during pregnancy so that a renin-like enzyme in the plasma produces effects such as the early clinical manifestations of pre-eclampsia; the overactivity of the reninlike enzyme may in turn lead to undue activity of other physiological systems including those of the coagulation and complement systems.
D000991:Antithrombins / Q000378:metabolism; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D003174:Complement C1 Inactivator Proteins; D004791:Enzyme Inhibitors / Q000378:metabolism*; D005260:Female; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D006801:Humans; D006868:Hydrolysis; D010447:Peptide Hydrolases / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism*; D012083:Renin / Q000097:blood; D014361:Trypsin Inhibitors / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000991:Antithrombins; D003174:Complement C1 Inactivator Proteins; D004791:Enzyme Inhibitors; D011506:Proteins; D014361:Trypsin Inhibitors; D000511:alpha-Macroglobulins; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D005341:Fibrinolysin; D012083:Renin