Association between exaggerated responsiveness to thyrotrophin-releasing hormone and hypercholesterolaemia.
Thyroid-function tests were performed on one hundred patients with suspected premyxoedema and the results compared with those in twenty age and sex matched controls. The increase in thyroid-stimulating hormone (T.S.H.) in response to thyrotrophin-releasing hormone (T.R.H.) was exaggerated in eighty-eight of the hundred patients with suspected premyxoedema. These included twenty-five with normal basal T.S.H. and sixty-three with a raised basal T.S.H. Serum-cholesterol concentration was significantly higher in those in whom premyxoedema was suspected than in the controls, even when patients presenting with degenerative arterial disease were excluded.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000302:isolation & purification; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013960:Thyroid Function Tests / Q000379:methods; D013961:Thyroid Gland / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D001323:Autoantibodies; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D002784:Cholesterol; D013974:Thyroxine