Increased tendency to spontaneous in-vitro lymphocyte transformation in clinically active multiple sclerosis.
Lymphocytes from 8 of 10 patients with clinically active multiple sclerosis (MS) but from only 3 of 18 patients with quiescent MS and 4 of 20 healthy donors transformed spontaneously on in-vitro culture. The transformed cells from all donors had the characteristics of B lymphocytes (surface and intracytoplasmic immunoglobulin and complement receptors) and carried antigens of Epstein-Barr virus. It is suggested that these results are further evidence that immunoregulation in active MS is abnormal.
D000914:Antibodies, Viral / Q000134:cerebrospinal fluid; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D008213:Lymphocyte Activation; D009103:Multiple Sclerosis / Q000276:immunology*; D011951:Receptors, Complement / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007136:Immunoglobulins; D011951:Receptors, Complement