A new case of gamma-3 heavy chain disease. Biochemical and immunological investigations.
A new gamma 3 heavy chain disease (gamma 3-HCD) protein (Emm) is described. A molecular weight of 70,000-80,000 daltons was estimated. Antigenic analysis showed that protein Emm lacks light chains and the CH1 domain of heavy chains, whereas the antigenic determinants of the gamma 3 Fc fragment (CH2 and CH3 domains) as well as those of the gamma 3 hinge region were present. Since the anomalous protein was temporarily present in serum Emm, a transient triggering of a cell clone which produces the gamma 3-HCD protein is suggested.
D055598:Chemical Phenomena; D002621:Chemistry; D000939:Epitopes; D005260:Female; D006362:Heavy Chain Disease / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007143:Immunoglobulin Heavy Chains / Q000276:immunology*; D007142:Immunoglobulin gamma-Chains / Q000276:immunology* / Q000302:isolation & purification; D008875:Middle Aged; D008970:Molecular Weight
D000939:Epitopes; D007106:Immune Sera; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains