Activation of human suppressor cells in mixed lymphocyte cultures.
Lymphocytes transferred from 6-day-old human mixed lymphocyte cultures (MLC) inhibited the response to allogeneic cells of freshly taken lymphocytes autologous to the transferred MLC-responding cells. No specificity for this cell-dependent suppression could be determined. The inhibitory effects of the suppressing cells could be abrogated by moderate X-ray irradiation and significantly reduced by pretreating them with an anti-Ia-like antiserum and complement. The human suppressor cell responsible for the observed effects therefore appears to carry determinants equivalent to the murine Ia alloantigens.
D003165:Complement System Proteins; D000939:Epitopes; D006801:Humans; D007106:Immune Sera; D008213:Lymphocyte Activation / Q000528:radiation effects; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D000939:Epitopes; D007106:Immune Sera; D003165:Complement System Proteins