title: Bleomycin (review).
abstract: Since the original observation and description of the various forms of Bleomycin (BLM), numerous articles have appeared dealing with the activity on mammalian cells and its possible clinical use. The present review on this very important compound, although not very comprehensive, deals with the important characteristics; such as the action of DNA and cells, and its chromosome breaking effects. The manner in which the minute detail of the action of BLM on cells has helped to implement in vivo chemotherapeutic regimes, is also discussed.
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D001761:Bleomycin; D004247:DNA