Cytostasis against self-antigens.
Effector cells from mice of the C57Bl/10 congenic series, alloimmunized against K end- or D end-identical I region incompatible lymphocytes, were cytostatic for tumour and macrophage targets bearing syngeneic K-end and D-end antigens. If incompatibility during immunization was restricted to the I-B subregion only, cytostasis was directed against K end syngeneic antigens; further incompatibility in the I region was required to obtain cytostasis against D-end self-antigens. Cytostasis against self-antigens was also obtained after immunization with syngeneic tumour cells; in one instance this was directed against syngeneic K-end antigens only. The implications of these findings in relation to neoplastic change and autoimmune damage are discussed.
D000818:Animals; D002455:Cell Division; D000939:Epitopes; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007519:Isoantigens; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D014185:Transplantation, Isogeneic
D000939:Epitopes; D006649:Histocompatibility Antigens; D007519:Isoantigens