Penicillin-induced coagulation disorder.
A coagulation disorder was seen after penicillin-G administration (10 million units/day) in uraemic patients and after high-dose penicillin G (40 million units/day) in patients with a normal glomerular filtration-rate (5 patients after cardiac surgery). This disorder was characterised by: prolongation of bleeding-time, appearing immediately after penicillin-G administration and persisting until 4 days after withdrawal of therapy; disturbance of collagen-induced and ristocetin-induced platelet aggregation; increase of antithrombin-III activity; and inhibition of factor-xa activity. The inhibition of factor-xa activity corresponded to that seen after low-dose-heparin prophylaxis. The clinically latent coagulation disorder, when super-imposed upon pre-existing coagulation abnormalities (uraemia, treatment with anti-coagulants) may cause severe bleeding, as observed in 1 patient with acute renal failure on haemodialysis.
D000038:Abscess / Q000097:blood / Q000150:complications / Q000188:drug therapy; D058186:Acute Kidney Injury / Q000097:blood / Q000150:complications; D000328:Adult; D001780:Blood Coagulation Tests; D005260:Female; D006474:Hemorrhagic Disorders / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D010400:Penicillin G / Q000009:adverse effects*; D010406:Penicillins / Q000627:therapeutic use; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced; D013530:Surgical Wound Infection / Q000517:prevention & control
D010406:Penicillins; D010400:Penicillin G