Gamma-globulins patterns in CSF of inflammatory neurological diseases in tropical Africa.
400 CSF electrophoreses were performed on Black West Africans (Ivory Coast) with inflammatory infections of the nervous system. In the normal state, the CSF of the Black African contains a higher concentration of gamma-globulins than the European (15.8% compared to 8--10%). This study permits us to confirm indirectly the classical idea of the extreme rarity of MS in tropical areas: an increase in the gamma-globulins of the CSF has been shown in 22% of the cases and the two principal responsible infections are trypanosomiasis (57.3%) and SSPE (16.8%). The oligoclonal distribution by various authors in trypanosomiases was not found. On the contrary, a nonclonal aspect of gamma-zone was constantly found (49/50). It is possible that the differences are in accordance with the different evolutionary phases of the disease, and that the oligoclonal distribution is a marker of the autoimmune state of the disease.
D000349:Africa; D001327:Autoimmune Diseases; D044383:Black People; D001797:Blood Protein Electrophoresis; D006801:Humans; D009443:Neuritis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology; D005719:gamma-Globulins / Q000134:cerebrospinal fluid*
D005719:gamma-Globulins