Canine distemper virus and multiple sclerosis.
Serum samples from patients with multiple sclerosis (M.S.), patients with subacute sclerosing panencephalitis (S.S.P.E.), and controls were examined for virus-neutralising antibodies against measles virus (M.V.) and 2 strains of canine distemper virus (C.D.V.). M.S. and S.S.P.E. patients had higher M.V. antibody titres than controls. In contrast, no significant differences were observed in mean C.D.V.-neutralising antibody titres between M.S. patients and controls. The results, though obtained from a small number of patients, fail to implicate C.D.V. in the aetiology of M.S.
D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification; D004199:Disease Vectors; D004216:Distemper / Q000382:microbiology* / Q000635:transmission; D004217:Distemper Virus, Canine / Q000276:immunology* / Q000472:pathogenicity; D004285:Dogs; D006801:Humans; D008459:Measles virus / Q000276:immunology / Q000472:pathogenicity; D009103:Multiple Sclerosis / Q000209:etiology / Q000382:microbiology*; D009500:Neutralization Tests; D013344:Subacute Sclerosing Panencephalitis / Q000382:microbiology*; D015047:Zoonoses
D000914:Antibodies, Viral