A neuronal nucleolar trigger mechanism traceable by a routine staining method.
In experimental Wilson's disease produced by the intracardiac injection of copper sulphate, it is seen that the glia-neuronal interactions play an important role in the pathogenesis of neural lesions. A "trigger" copper-RNA particle is transferred from the oligodendroglial nucleus to activate the neuronal nucleolus causing a flooding of the neurone with RNA. This trigger particle stains differently with Mason's trichrome, giving a bright red colour. This altered reaction gives an insight into the feedback process for the formation of ribosomal RNA in the neurones. The alteration appears to lead to a block in the repressor activity of the neuronal RNA formation.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002466:Cell Nucleolus / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D003300:Copper; D003593:Cytoplasm / Q000378:metabolism; D006527:Hepatolenticular Degeneration / Q000139:chemically induced / Q000378:metabolism*; D006651:Histocytochemistry; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009562:Nissl Bodies / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D051381:Rats; D013194:Staining and Labeling
D012335:RNA, Ribosomal; D012313:RNA; D003300:Copper