In vitro studies on H-2 linked unresponsiveness to synthetic polypeptide antigens. II. Induction of suppressor cells in both responsive and unresponsive mice to (T,G)-A-L and GAT;.
Antigen-specific T-suppressor cells can be induced in vitro from unprimed lymphoid cells of high responder (C57BL/10) and low responder (B10.Br, B10.A, CBA) mice to (T,G)-A-L and high responder (B10, B10;A) and non-responder (B10.G, DBA/1) mice to GAT10. The suppressor cells induced from high and low or non-responder mice appear identical in efficiency, in the antigen concentration required for induction and in their induction kinetics.
D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes; D005796:Genes; D006648:Histocompatibility; D007108:Immune Tolerance; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000939:Epitopes; D010455:Peptides