Channel structures of gramicidin: characterization of succinyl derivatives.
Succinyl derivatives of gramicidin were tested for their ability to form channels in planar artificial lipid bilayers. Both N-succinyldeformylgramicidin methyl ester and charged O-succinylgramicidin formed channels, but the channels had markedly different sizes and lifetimes. This implies that gramicidin forms channels by end-to-end association. However, the doubly charged N,O-bissuccinyldeformylgramicidin was inactive, which suggests that only end-to-end association of gramicidin may result in channel formation.
D004553:Electric Conductivity; D006096:Gramicidin; D006860:Hydrogen Bonding; D007476:Ionophores; D008567:Membranes, Artificial; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D007476:Ionophores; D008567:Membranes, Artificial; D006096:Gramicidin