Independent segregation of two functional markers expressed on the same B-cell subset in the mouse: the Mls determinants and LPS receptors.
Mice of the C3H/Tif strain display a mixed leukocyte reaction (MLR) with all H-2k strains carrying any of the known alleles of the Mls locus. In particular, C3H/Tif is incompatible with the related substrain C3H/HeJ, from which it also differs at the locus responsible for the recognition of lipopolysaccharides (LPS) as B-cell mitogens, and at the Mod-1 locus. Our genetic analysis indicates that the MLR incompatibility between these strains is not H-2-linked and segregates as controlled by a single locus, most probably identical to Mls, for which the C3H/Tif strain expresses a previously unidentified allele, Mlse. Moreover, segregation data show that this locus assorts independently of LPS responsiveness and that neither marker is closely linked to the Mod-1 locus in linkage group II.
D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology*; D000939:Epitopes; D008040:Genetic Linkage; D006183:H-2 Antigens; D006650:Histocompatibility Testing; D008070:Lipopolysaccharides / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D008934:Mitogens; D011955:Receptors, Drug
D000939:Epitopes; D006183:H-2 Antigens; D008070:Lipopolysaccharides; D008934:Mitogens; D011955:Receptors, Drug