Absorption, hydroxylation, and excretion of vitamin D3 in primary biliary cirrhosis.
Oral vitamin D3 was poorly absorbed by 4 out of 6 patients with primary biliary cirrhosis; absorption was negatively correlated with faecal fat excretion. 25-hydroxylation of vitamin D3 given by mouth or intravenously was not impaired in the patients compared with controls of similar vitamin-D nutritional status. Urinary radioactivity derived from the intravenous dose of vitamin D3 was significantly greater in patients than in controls and was positively correlated with the serum-bilirubin concentration. Excretion in the urine may lead to loss of administered and endogenous vitamin D and thus contribute to vitamin-D deficiency in patients with primary biliary cirrhosis.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D002762:Cholecalciferol / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D006801:Humans; D006900:Hydroxylation; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007553:Isotope Labeling; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008105:Liver Cirrhosis, Biliary / Q000378:metabolism*; D008875:Middle Aged
D002250:Carbon Radioisotopes; D008055:Lipids; D002762:Cholecalciferol