The tumor-producing effect of automobile exhaust condensate and fractions thereof. Part II: animal studies.
The induction of squamous cell carcinomas and papillomas in a total of 1,950 mice in a lifelong skin-dropping experiment with different doses of automobile exhaust condensate and its fractions is described. Results of the dose-response studies reported indicate that local oncogenic activity of automobile condensate is contained primarily in its polycyclic aromatic hydrocarbon-fractions. In addition, findings in lung tumor incidences are given. Results of the sebaceous gland suppression screening test were found to be comparable to findings of the skin-dropping experiments.
D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D012627:Sebaceous Glands / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced; D013997:Time Factors; D001335:Vehicle Emissions / Q000009:adverse effects* / Q000032:analysis
D001335:Vehicle Emissions