[Toxicity, pharmacokinetics and pharmacodynamics of the Soviet bleomycin, bleomycetin, in a single administration to laboratory animals].
Toxicity of bleomycetin (bleomycin A2) administered intravenously, intraperitoneally, subcutaneously or intramusculary in a single dose to animals was almost identical. On its oral administration bleomycetin was 10--14 times less toxic than on its parenteral use. Rats were somewhat less sensitive to bleomycetin than mice. Bleomycetin had no significant effect on the level of the arterial pressure, respiration, ECG characteristics and elements of the vegetative nervous system in narcotized cats. After a single intravenous or subcutaneous administration to rabbits bleomycetin was detectable in the blood for 4--5 hours. The highest bleomycetin levels were registered in the skin, kidneys and lungs. Bleomycetin was mainly excreted with the urine.
D000818:Animals; D001702:Biopharmaceutics; D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014586:USSR
D001761:Bleomycin
Izuchenie toksichnosti, farmaokinetiki i farmakodinamiki otechestvennogo bleomitsina--bleomitsetina pri odnokratnom vvedeni laboratornym zhivotnym.