Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944.
Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D003510:Cyclohexanes / Q000494:pharmacology*; D003864:Depression, Chemical; D004195:Disease Models, Animal; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D009542:Niemann-Pick Diseases / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D010743:Phospholipids / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000096:biosynthesis*; D051381:Rats; D013108:Sphingomyelin Phosphodiesterase / Q000096:biosynthesis* / Q000378:metabolism; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride / Q000494:pharmacology*
D003510:Cyclohexanes; D010743:Phospholipids; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; D002784:Cholesterol; D010727:Phosphoric Diester Hydrolases; D013108:Sphingomyelin Phosphodiesterase