Selective inactivation of vitamin B12 in rats by nitrous oxide.
Exposure of rats to nitrous oxide rapidly inactivated the cytosol enzyme, methionine synthetase, but the mitochondrial enzyme, methylmalonyl CoA mutase, seemed to be unaffected, although both enzymes require vitamin B12.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D008099:Liver / Q000166:cytology; D008764:Methylmalonic Acid / Q000652:urine; D008765:Methylmalonyl-CoA Mutase / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D009609:Nitrous Oxide / Q000494:pharmacology*; D051381:Rats; D014805:Vitamin B 12 / Q000037:antagonists & inhibitors*; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced* / Q000201:enzymology
D008764:Methylmalonic Acid; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D008765:Methylmalonyl-CoA Mutase; D009609:Nitrous Oxide; D014805:Vitamin B 12