Human embryonic prealbumin as a marker for tumours and fibroblasts.
Embryonic prealbumin (E.P.A.) was demonstrated by agar immunodiffusion in 122 out of 505 homogenates of various tumours and in 7 out of 20 serum samples from patients with connective-tissue tumours. Analogous antigen was found in human embryonic and adult cultured fibroblasts. This newly identified antigen is probably actively secreted by fibroblasts into the circulation of patients with tumours.
D000328:Adult; D002272:Carcinoembryonic Antigen / Q000302:isolation & purification*; D002478:Cells, Cultured; D004622:Embryo, Mammalian / Q000166:cytology / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion / Q000379:methods; D007122:Immunoelectrophoresis / Q000379:methods; D009369:Neoplasms / Q000276:immunology*; D011228:Prealbumin / Q000276:immunology*; D011247:Pregnancy; D012709:Serum Albumin / Q000276:immunology*
D002272:Carcinoembryonic Antigen; D006023:Glycoproteins; D011228:Prealbumin; D012709:Serum Albumin