Altered theophylline pharmacokinetics during acute respiratory viral illness.
The plasma half-life of theophylline was determined during and 1 month after serologically confirmed upper-respiratory-tract viral illness in six children with chronic asthma. In this group the plasma-theophylline half-life (mean = 419.8 min) was significantly longer during the acute stage of their illness than 1 month later (mean 249.9 min). There was no appreciable change in half-life in 4 patients who were febrile but in whom seroconversion did not occur. These preliminary results suggest that certain upper-respiratory-tract viral infections may affect theophylline metabolism.
D000208:Acute Disease; D000257:Adenoviridae Infections / Q000188:drug therapy* / Q000378:metabolism; D000258:Adenovirus Infections, Human / Q000188:drug therapy*; D000293:Adolescent; D001249:Asthma / Q000150:complications / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D005260:Female; D006207:Half-Life; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000378:metabolism; D013806:Theophylline / Q000378:metabolism* / Q000627:therapeutic use
D013806:Theophylline