Phototoxic reaction to long-term low-dose administration of chlorpromazine in mice.
The mouse tail in vivo technique for the study of acute drug phototoxicity was tested in experiments involving prolonged administration of chlorpromazine and ultraviolet light. A phototoxic reaction was induced with lower combined doses of drug and radiation than was the case in single exposures.
D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004890:Erythema / Q000209:etiology; D005260:Female; D051379:Mice; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D013623:Tail; D013997:Time Factors; D014466:Ultraviolet Rays
D002746:Chlorpromazine