title: Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital.
abstract: The boys of Christ's Hospital experienced outbreaks of influenza A in 1972 (A/England/42/72), in 1974 (A/Port Chalmers), and in 1976 (A/Victoria). In each outbreak, the protective effect of inactivated influenza-A vaccine was limited to those boys, not already immune, who were vaccinated for the first time with the most up-to-date strain. Revaccination with the same strain did not increase the degree of protection, and revaccination with a later strain did not afford protection against subsequent challenge. The cummulative attack-rate in the three outbreaks was similar in all groups irrespective of vaccination history. These observations suggest that annual revaccination with inactivated influenza-A vaccine confers no long-term advantage.
mesh_terms: D000293:Adolescent; D002648:Child; D004196:Disease Outbreaks / Q000453:epidemiology / Q000517:prevention & control*; D004739:England; D005069:Evaluation Studies as Topic; D006801:Humans; D007117:Immunization, Secondary; D009980:Influenza A virus; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology / Q000627:therapeutic use; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D012572:School Health Services; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated