Suppression of specific MLC responsiveness during skin allograft rejection in rats.
During the effector phase of allograft rejection a specific MLC unresponsiveness of PBL has been observed in skin-grafted rats. This unresponsiveness is caused by a suppressive effect that is dependent on a cooperative interaction between macrophages and alloantigen-activated T cells. The interaction is mediated by a soluble factor released from the alloantigen-activated T cells on exposure to the specific antigen. The suppression itself is nonspecific.
D000818:Animals; D000939:Epitopes; D006084:Graft Rejection; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000939:Epitopes