Independent mobility of cholera toxin binding sites and Thy-1 alloantigen on mouse thymocytes.
The hypothesis that Thy-1.2 carries a carbohydrate antigenic determinant with the same specificity as the monosialoganglioside GM1 was tested by attempting to co-cap Thy-1.2 and GM1 in CBA thymocytes using anti-Thy-1.2 alloantiserum and cholera toxin. Co-capping of these determinants was not observed suggesting that they are on separate molecules. We do not therefore confirm the previous reported association between Thy-1 and GM1 (Thiele, Arndt & Stark, 1977).
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology; D002772:Cholera Toxin / Q000276:immunology*; D000939:Epitopes; D005677:G(M1) Ganglioside / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D007152:Immunologic Capping; D007519:Isoantigens; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D005732:Gangliosides; D007519:Isoantigens; D005677:G(M1) Ganglioside; D002772:Cholera Toxin