Raman spectroscopic investigation of the interaction of gramicidin A with dipalmitoyl phosphatidylcholine liposomes.
The interaction of gramicidin A with dipalmitoyl phosphatidylcholine liposomes is investigated by Laser-Raman spectroscopy. As revealed by the methylene C-H stretching mode the phase transition of the hydrocarbon chains near 40 degree C is eliminated in the presence of gramicidin A. Liposomes prepared from a mixture of lecithin and cholesterol seem to be unaffected by gramicidin A and show only the normal broadened phase transition.
D001665:Binding Sites; D006096:Gramicidin; D007700:Kinetics; D008081:Liposomes; D008968:Molecular Conformation; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D011485:Protein Binding; D011487:Protein Conformation; D013059:Spectrum Analysis, Raman; D013696:Temperature
D008081:Liposomes; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D006096:Gramicidin