Expression of I-A and I-E,C region-coded Ia antigens on functional B cell subpopulations.
Ia antigens from specific subregions have been examined on functional B cell populations. Expression of both I-A and I-E,C region antigens was demonstrated on cells required for both lipopolysaccharide mitogenesis and polyclonal activation. Similar I-A and I-E,C subregion expression was found on cells required for response to the T-independent antigen, polyvinylpyrrolidone. TNP-specific IgM and hen egg lysozyme-specific IgG plaque-forming cells also express I-A and I-E,C region antigens. No evidence was found for an Ia- population responsive in the systems tested. Further, no evidence of preferential expression of I-A or I-E,C region antigens was observed in any system examined. Therefore, it appears that B cells express both I-A and I-E,C region-coded Ia antigens.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D000939:Epitopes; D005815:Genetic Code; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G; D007519:Isoantigens / Q000235:genetics*; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D013154:Spleen / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology
D000939:Epitopes; D007106:Immune Sera; D007074:Immunoglobulin G; D007519:Isoantigens; D014301:Trinitrobenzenes