Chelates of dicumarol I: Preparation and structure identification of magnesium chelate.
A magnesium chelate of dicumarol was prepared by reacting a suspension of dicumarol and magnesium oxide in 50% water-methanol. GLC, thermogravimetric, and elemental analyses showed that this compound has a 2:1 ligand-metal stoichiometry with 2 moles of water associated with the complex. Although the chelate does not melt, two endothermic peaks at 205 and 274 degrees were observed in the thermogram, in contrast to a single endothermic peak corresponding to a melting point of 288 degrees for dicumarol. IR spectroscopy indicated that the magnesium is bonded between the carbonyl at C-2 and the oxygen at C-4' (or vice versa).
D002244:Carbon / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D003720:Densitometry; D001728:Dicumarol / Q000138:chemical synthesis*; D004055:Differential Thermal Analysis; D006859:Hydrogen / Q000032:analysis; D008274:Magnesium; D009682:Magnetic Resonance Spectroscopy; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared
D002244:Carbon; D001728:Dicumarol; D006859:Hydrogen; D008274:Magnesium