Lower plants as a source of anticancer drugs.
The NCI's antineoplastic fermentation program is reviewed. Clinically useful antitumor antibiotics are discussed in terms of their activity, mechanism of action, and the producing microbe.
D000192:Actinomycetales / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification; D001761:Bleomycin / Q000302:isolation & purification / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D003609:Dactinomycin / Q000302:isolation & purification / Q000627:therapeutic use; D003630:Daunorubicin / Q000302:isolation & purification / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D006801:Humans; D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000188:drug therapy; D008926:Plicamycin / Q000302:isolation & purification / Q000627:therapeutic use; D013241:Sterigmatocystin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000627:therapeutic use; D013302:Streptomyces; D014481:United States
D000903:Antibiotics, Antineoplastic; D013241:Sterigmatocystin; D001761:Bleomycin; D003609:Dactinomycin; D008926:Plicamycin; D003630:Daunorubicin