title: Electron microscopical and biochemical investigations on retra viruses in spleen tissue in malignancy.
abstract: Simultaneous biochemical and electron microscopical investigations on surgically removed spleens yielded evidence for the presence of reverse transcriptase containing (Retra) virus in two patients with hematological malignancies with spleen involvement. In three other patients with hematological diseases and in one control patient, the spleens were negative in both assays. The results of these combined studies support the view, that retraviruses are present in human malignancies.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007181:Inclusion Bodies, Viral; D007943:Leukemia, Hairy Cell / Q000382:microbiology; D008223:Lymphoma / Q000382:microbiology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000382:microbiology; D012328:RNA Viruses / Q000201:enzymology / Q000302:isolation & purification*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D013160:Splenic Neoplasms / Q000201:enzymology / Q000382:microbiology* / Q000648:ultrastructure
chemical_list: D012194:RNA-Directed DNA Polymerase