title: [Acid reduction and ulcer healing through vagotomy: is an inhibition of histamine release an essential reason for this?].
abstract: In a prospective, consecutive study the histamine content of corpus mucosa and the basal and maximally stimulated acid output were measured in male patients who had selective vagotomy to correct a chronic duodenal ulcer. The increase in histamine content after vagotomy was directly proportional to a decrease in maximum acid output. The relationships between histamine content, recurrent ulcer, and reduction in acid output point to a causal relationship between inhibition of histamine release and successful vagotomy.
mesh_terms: D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000503:physiopathology / Q000601:surgery*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006636:Histamine Release; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D014628:Vagotomy
vernacular_title: Säurereduktion and Ulcusheilung durch Vagotomie: Ist eine Hemmung der Histaminfreisetzung hierfür eine wesentliche Ursache?