Growth-stimulating factor in regenerating canine liver.
Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. The response reached its peak 3 days later. In the left but not the right liver lobes, both the 48-h and the 72-h regenerating liver extract reversed the atrophy ordinarily caused by Eck fistula in 3 days and partly prevented the ultrastructural hepatocyte deterioration characteristic of Eck fistula. The active liver extracts apparently contained a growth-control factor or factors which is (are) not insulin or glucagon.
D000818:Animals; D002452:Cell Count; D004285:Dogs; D006133:Growth Substances / Q000008:administration & dosage / Q000494:pharmacology*; D006498:Hepatectomy; D007263:Infusions, Parenteral; D008099:Liver / Q000473:pathology; D008110:Liver Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D008115:Liver Regeneration; D008938:Mitosis; D011167:Portacaval Shunt, Surgical; D011169:Portal Vein; D011183:Postoperative Complications / Q000517:prevention & control; D013268:Stimulation, Chemical
D006133:Growth Substances; D008110:Liver Extracts