title: Raised alpha-fetoprotein levels in amniotic fluid and maternal serum associated with distension of the fetal bladder caused by absence of urethra.
abstract: Raised alpha-fetoprotein concentrations were found at 29 and 30 weeks' gestation in the amniotic fluid and maternal serum of a woman who presented in her seventh pregnancy with apparent polyhydramnios. The fetus had multiple abnormalities including gross distension of the bladder resulting from absence of the urethra, intestinal artresia, and a congenital heart defect.
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D014521:Urethra / Q000002:abnormalities*; D001745:Urinary Bladder Diseases / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins