title: Specificity and effector-target interaction.
abstract: When effector cells were tested on a number of target cells, the most obvious effect observed was a nonselective cytotoxicity that is now known as natural cell-mediated cytotoxicity. The apparent nonselectivity was a result of specific cytotoxic activity against many different antigens on target cells. This specificity was demonstrated in the cross-competition assay in which target cells sharing common antigens selectively inhibited natural cytotoxicity.
mesh_terms: D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D066298:In Vitro Techniques
chemical_list: D000939:Epitopes