title: Prevention of necrotising enteritis in Papua New Guinea by active immunisation.
abstract: Necrotising enteritis (pig-bel) caused by Clostridium welchii type C is a major cause of illness and death in the Highlands of Papua New Guinea. In a controlled trial of active immunisation with a clostridial toxoid prepared from type-C cultures the incidence of pig-bel in over 2500 immunised children within 24 months of immunisation was less than an eighth of that in a control group. Necrotising enteritis in Papua New Guinea is now a preventable disease.
mesh_terms: D000293:Adolescent; D000992:Antitoxins / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003015:Clostridium Infections / Q000517:prevention & control*; D003016:Clostridium perfringens / Q000276:immunology; D004311:Double-Blind Method; D004751:Enteritis / Q000209:etiology / Q000517:prevention & control*; D004761:Enterocolitis, Pseudomembranous; D005260:Female; D006801:Humans; D007114:Immunization; D007115:Immunization Schedule; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D009336:Necrosis; D009512:New Guinea; D014121:Toxoids / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000992:Antitoxins; D001428:Bacterial Vaccines; D014121:Toxoids