Relationship between leukemia antigens and stimulation in mixed leukocyte culture.
Leukemia cells from 13 of 27 patients stimulated lymphocytes of their HLA-identical siblings in mixed leukocyte cultures (MLC). Stimulation correlated with high background uptake of tritiated thymidine and high percentages of cells that stained with fluorescein-conjugated polyvalent goat antiserum against human immunoglobulin. Results were similar to those reported with fractionated autologous lymphocyte subpopulations in normal individuals. Investigation of leukemia-specific stimulation in MLC is therefore problematic.
D000951:Antigens, Neoplasm; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes; D005191:Family Characteristics; D006680:HLA Antigens; D006801:Humans; D007109:Immunity; D007938:Leukemia / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000939:Epitopes; D006680:HLA Antigens