Protein-binding polyhedral boranes.
A series of polyhedral borane derivatives containing protein-binding functional groups has been synthesized. Problems encountered in earlier studies (low incorporation levels, gross precipitation of conjugates) have been overcome by including a water-solubilizing gluconamide group in the structure. This modification has allowed high levels of boron to be covalently bound to HGG, forming a completely water-soluble conjugate.
D001880:Boranes / Q000138:chemical synthesis* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D005719:gamma-Globulins / Q000378:metabolism
D001880:Boranes; D011506:Proteins; D005719:gamma-Globulins