Toxic fatty acid resistant mutant of Trichophyton rubrum.
A mutant of Trichophyton rubrum which could tolerate high concentration (110 microgram/ml) of undecanoic acid was isolated from undecanoic (27.5 microgram/ml) sensitive parent. The mutant showed cross resistance towards other fatty acids like propionic acid, caprylic acid and undecenoic acid which were toxic for the parent strain. Development of fatty acid resistance in the mutant strain was associated with increased pigment production. There was no difference in colony or cell morphology between fatty acid resistant mutant and fatty acid sensitive parent.
D002210:Caprylates / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005227:Fatty Acids / Q000494:pharmacology*; D009154:Mutation; D011422:Propionates / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects*; D014476:Undecylenic Acids / Q000494:pharmacology
D002210:Caprylates; D005227:Fatty Acids; D011422:Propionates; D014476:Undecylenic Acids; C016173:undecanoic acid