Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary biliary cirrhosis.
Bone histology and intestinal absorption of 25-hydroxyvitamin D3 (25-OHD) were investigated in 11 patients with primary biliary cirrhosis (P.B.C.). 4 patients had osteomalacia, and all these had received long-term cholestyramine. Plasma-25-hydroxyvitamin-D (25-OHD) concentrations after an oral dose of 25-OHD3 were significantly lower in the patients with P.B.C. (especially those with osteomalacia) than in normal controls. Serum calcium and urinary calcium excretion were lower, and serum-alkaline-phosphatase higher, in patients with osteomalacia. It is suggested that absorption of 25-OHD undergoing enterohepatic circulation and of dietary vitamin D is reduced in patients with P.B.C. Absorption of 25-OHD is further decreased by cholestyramine and the development of osteomalacia is thus hastened.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001842:Bone and Bones / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D002792:Cholestyramine Resin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood / Q000378:metabolism*; D007408:Intestinal Absorption; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008286:Malabsorption Syndromes / Q000139:chemically induced / Q000150:complications; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D014808:Vitamin D Deficiency / Q000150:complications / Q000209:etiology
D006887:Hydroxycholecalciferols; D002792:Cholestyramine Resin; D000469:Alkaline Phosphatase; D001663:Bilirubin; D002118:Calcium