About some common biochemical and pharmacological properties of bile salts and non steroidal anti-inflammatory drugs.
Glyco- and tauro-deoxycholate, -chenodeoxycholate, -dehydrocholate and -cholate uncouple the mitochondrial oxidative phosphorylation in this order of potency. They also induce pseudo-energized mitochondrial swelling and lymphocyte swelling in the same order of potency. Similar swelling properties were observed for glyco- and tauro-lithocholate. Glyco- and tauro-deoxycholate induce alkalinization of the intra-mitochondrial space as determined on bromothymol blue pre-loaded mitochondria. These two bile salts conjugates also increase the amount of -SH groups available on lymphocyte membranes for sulfhydryl-disulfide interchange reactions. All these biochemical properties have been described for non-steroidal anti-inflammatory drugs. They could thus be implicated in the jaundice remission observed in various inflammatory states.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001647:Bile Acids and Salts / Q000494:pharmacology*; D004228:Dithionitrobenzoic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008634:Mersalyl / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D009941:Organomercury Compounds / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology; D013950:Thymus Gland / Q000502:physiology; D014475:Uncoupling Agents
D000893:Anti-Inflammatory Agents; D001647:Bile Acids and Salts; D009941:Organomercury Compounds; D014475:Uncoupling Agents; D008634:Mersalyl; D004228:Dithionitrobenzoic Acid