The effect of nasal decongestant on nasal mucous velocity.
Nasal mucous velocity was measured in 13 healthy nonsmokers before and 10 min after topical application of 2 alpha adrenergic nasal decongestant sprays, phenylephrine and tetrahydrozoline. Phenylephrine increased nasal mucous velocity from 8.4 +/- 2.7 mm per min (mean +/- SD) to 13.7 +/- 4.8 mm per min and tetrahydrozoline from 8.1 +/- 3.8 mm per min (mean +/- SD) to 13.8 +/- 5.1 mm per min. These increases were significant (P less than 0.01) when compared to topical application of phenylephrine and tetrahydrozoline vehicles, normal saline, and sham (empty aerosol container).
D000287:Administration, Topical; D000328:Adult; D000336:Aerosols; D000368:Aged; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D004338:Drug Combinations; D004349:Drug Packaging; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000187:drug effects*; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000187:drug effects; D014677:Pharmaceutical Vehicles; D010656:Phenylephrine / Q000494:pharmacology; D012212:Rheology; D012965:Sodium Chloride / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D000336:Aerosols; D001548:Benzalkonium Compounds; D002951:Citrates; D004338:Drug Combinations; D007093:Imidazoles; D014663:Nasal Decongestants; D014677:Pharmaceutical Vehicles; D013764:Tetrahydronaphthalenes; D010656:Phenylephrine; D012965:Sodium Chloride; D004492:Edetic Acid; D006851:Hydrochloric Acid