Localization of genetic control in mice over response to liver-specific F antigen.
Antibody production to the liver-specific F antigen was tested in recombinant strains of mice of different H-2 types to determine whether a histocompatibility-linked immune response (Ir) gene controlled responsiveness to this antigen. Responseiveness was found to be controlled by an Ir gene located in the K end (K and/or I-A subregions) of the H-2 complex.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001324:Autoantigens; D000939:Epitopes; D005260:Female; D005802:Genes, MHC Class II; D008099:Liver / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic
D000941:Antigens; D001324:Autoantigens; D000939:Epitopes