Ocular findings in systemic cutaneous basophil hypersensitivity.
SCBH was induced by immunizing guinea pigs with a protein antigen and challenging 1 week later with a large intraperitoneal dose of the same antigen. Animals developed a delayed-onset, erythematous skin rash and dermal infiltration by basophils and eosinophils. The uveal tracts of these animals were infiltrated by eosinophils, as were several other internal organs. The eye is affected in SCBH, and as in other forms of ocular cell-mediated hypersensitivity, the eosinophil is a prominent cellular component of these reactions.
D000818:Animals; D001491:Basophils; D002829:Choroid / Q000473:pathology; D002924:Ciliary Body / Q000473:pathology; D004804:Eosinophils; D004890:Erythema / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000473:pathology*; D007958:Leukocyte Count; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D014603:Uveal Diseases / Q000473:pathology*; D005719:gamma-Globulins / Q000276:immunology
D005719:gamma-Globulins; D010047:Ovalbumin