title: Prostaglandin E, pessaries for induction of labour.
abstract: Vaginal pessaries containing 3 mg of prostaglandin E2 were used to induce labour in 200 patients with variable induction features. Prostaglandin-induced labour was augmented where necessary by synthetic oxytocin. There was on failed induction. Only 23% of patients with favourable induction features and 53% of patients with unfavourable features needed oxytocin. There were no adverse fetal or maternal effects. The prostaglandin E2 pessary was as effective in inducing labour as 350 microgram extra-amniotic prostaglandin E2 in tylose in a comparable group of 200 patients in which there were 4 failed inductions.
mesh_terms: D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives; D002584:Cervix Uteri / Q000187:drug effects*; D004341:Drug Evaluation; D005260:Female; D007751:Labor, Induced; D009824:Ointments; D010121:Oxytocin / Q000627:therapeutic use; D010298:Parity; D010570:Pessaries; D014677:Pharmaceutical Vehicles; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage* / Q000494:pharmacology; D014621:Vagina / Q000187:drug effects
chemical_list: D009824:Ointments; D014677:Pharmaceutical Vehicles; D011459:Prostaglandins E, Synthetic; D010121:Oxytocin; D002482:Cellulose