[Immunochemical study of the specific antigens of human amniotic fluid].
Four specific antigens (trophoblastic beta 1-globulin, placental lactogen, alpha 1- and alpha 2-globulins of human placenta) were identified using antisera to the native amniotic fluid. Five antigens with the mobility of prealbumins, alpha 1-globulins, alpha 2-globulins and beta 2-globulins which bear no resemblance with the previously studied antigens were identified using antisera to the acid fraction of the amniotic fluid. Both the prealbumins and alpha 2-globulin were found in the blood serum of foetuses of different age and of newborn infants; these proteins were absent from the blood serum of pregnant women and donors. They received the names of embryonic prealbumine 1, embryonic prealbumine 2 and embryonic alpha 2-globulin. The protein with the mobility of alpha 1-globulins was found in the amniotic fluid of foetuses and in the blood serum of pregnant women only and received the name of amniotic alpha 1-globulin. The concentration of the antigens in question was studied in the developing foetuses and in the blood serum of pregnant women at different stages of pregnancy.
D000510:Alpha-Globulins / Q000032:analysis; D000653:Amniotic Fluid / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000032:analysis*; D001609:Beta-Globulins / Q000032:analysis; D000939:Epitopes; D005260:Female; D005865:Gestational Age; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization; D005779:Immunodiffusion / Q000379:methods; D007122:Immunoelectrophoresis / Q000379:methods; D007123:Immunoelectrophoresis, Two-Dimensional / Q000379:methods; D007231:Infant, Newborn; D011228:Prealbumin / Q000032:analysis; D011247:Pregnancy; D011817:Rabbits; D013997:Time Factors
D000510:Alpha-Globulins; D000941:Antigens; D001609:Beta-Globulins; D000939:Epitopes; D007106:Immune Sera; D011228:Prealbumin
Immunokhimicheskoe izuchenie spetsificheskikh antigenov amnioticheskoĭ zhidkosti cheloveka.