[Results of long-lasting drug intake on child development; clinical and electrophysiological study during drug withdrawal].
The case of a child under continuous anticonvulsant medication, especially barbiturate, since the age of 8 months for atypical seizures is reported. Medication was withdrawn when the child was 7.7 years old. The child was then under care in a Day Hospital with an autistic-like syndrome associated with important disturbances of sleep-waking regulation, complete learning incapability and major EEG abnormalities. The EEG paroxysmal discharges observed in the waking and all-night sleep records gradually decreased and then disappeared as the withdrawal was pursued over a period of several months. During the same period, the child's behaviour markedly improved and his sleep disturbances disappeared. The possibility of iatrogenic effects of early and continuous anti-convulsant therapies is discussed, even though the drug plasma levels remain within ranges generally considered as non-toxic.
D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001463:Barbiturates / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000139:chemically induced; D004569:Electroencephalography; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012893:Sleep Wake Disorders / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013997:Time Factors
D000927:Anticonvulsants; D001463:Barbiturates
Conséquences de l'imprégnation médicamenteuse de longue durée sur le développement de l'enfant; étude clinique et éléctrophysiologique au cours du sevrage.