Sequential studies on components of the haemostatic mechanism in pregnancy with particular reference to the development of pre-eclampsia.
Components of the haemostatic mechanism were studied at intervals in 60 primigravidae over the course of pregnancy and the puerperium; 12 of these developed pre-eclampsia. During pregnancy there was a fall in fibrinolytic activity and fibrinolytic capacity and a rise in fibrinogen, FR-antigen, alpha 1-antitrypsin and alpha 2-macroglobulin. The women who subsequently developed pre-eclampsia could not be identified on the basis of these measurements. Following delivery there was a more rapid return of fibrinolytic activity and capacity towards normal in the women who had not had pre-eclampsia. The urinary FR-antigen level was higher in the women with pre-eclampsia.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000652:urine; D005260:Female; D005337:Fibrin / Q000276:immunology; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis; D006801:Humans; D010958:Plasminogen / Q000032:analysis*; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine; D011247:Pregnancy; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000941:Antigens; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D005337:Fibrin; D005340:Fibrinogen; D010958:Plasminogen