title: Erythrocyte-sedimentation rate before and after in-vitro defibrination: A rapid and simple method for increasing its specificity.
abstract: The erythrocyte-sedimentation rate (E.S.R.) was measured before and after in-vitro defibrination in 107 patients with high E.S.R.S. The reduction in E.S.R. on defibrination correlates with the fibrinogen level while the post-defibrination E.S.R. correlates with the globulin level. The ratio between the post-defibrination E.S.R. and the pre-defibrination, or standard, E.S.R. varies with different diseases; it is highest when an excess of globulins is the cause of the high E.S.R. and lowest when there is an excess of fibrinogen. Measurement of the post-fibrination E.S.R. is quick and easy and may help in the initial investigation of a high E.S.R.
mesh_terms: D001796:Blood Protein Disorders / Q000097:blood; D001799:Blood Sedimentation / Q000379:methods*; D003095:Collagen Diseases / Q000097:blood; D005337:Fibrin; D005340:Fibrinogen / Q000032:analysis; D005734:Gangrene; D006801:Humans; D066298:In Vitro Techniques; D007239:Infections / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood; D009369:Neoplasms / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis
chemical_list: D012709:Serum Albumin; D012712:Serum Globulins; D005337:Fibrin; D005340:Fibrinogen