In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.
The in vitro production, assay and partial characterization of an extremely potent antigen-specific T helper cell factor to poly-L-(Tyr, Glu)-poly-DL-Ala--poly-L-Lys [(T,G)-A--L] which may be an important physiological mediator of T cell function in vivo is described. The factor has an antigen-binding site, Ia and Ig-like determinants on the same molecular complex. The response to (T, G)-A--L is under H-2-linked Ir gene control, some but not all low responder haplotypes will produce the factor.
D000818:Animals; D001666:Binding Sites, Antibody; D003429:Cross Reactions; D004136:Dinitrobenzenes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D008040:Genetic Linkage; D006238:Haploidy; D006649:Histocompatibility Antigens; D007164:Immunosorbents; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D004136:Dinitrobenzenes; D000939:Epitopes; D006649:Histocompatibility Antigens; D007164:Immunosorbents; D010455:Peptides