HLA restriction of non-HLA--A, --B, --C and --D cell mediated lympholysis (CML).
The aim of our study was to define target determinants other than those coded for by the classical HLA-A, -B, -C or -D loci which were responsible for killing in CML. In one of the families studied, strong evidence was found for the existence of a determinant coded for within the HLA region. CML was restricted to targets carrying the classical HLA-Bw35 and Cw4 determinants but the targets were neither HLA-Bw35 nor Cw4 themselves. We therefore concluded that this new HLA determinant was either the product of a new locus closely associated with HLA-B or that it was a product of the classical HLA-B locus which has not been recognized by serology.
D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005260:Female; D005838:Genotype; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010375:Pedigree
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens