Bone-marrow transplant from an unrelated donor for chronic granulomatous disease.
A boy with chronic granulomatous disease received a bone-marrow graft from a fully compatible unrelated donor, in association with a modified immunosuppressant regimen. He showed considerable clinical improvement with definite evidence of engraftment, and he has enjoyed a normal life for over 3 years.
D000017:ABO Blood-Group System; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival; D006105:Granulomatous Disease, Chronic / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D009504:Neutrophils; D009580:Nitroblue Tetrazolium; D010585:Phagocyte Bactericidal Dysfunction / Q000628:therapy*; D011300:Preoperative Care; D012204:Rh-Hr Blood-Group System; D012729:Sex Chromosome Aberrations; D014019:Tissue Donors; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D006680:HLA Antigens; D012204:Rh-Hr Blood-Group System; D009580:Nitroblue Tetrazolium; D003520:Cyclophosphamide