Acupuncture in heroin addicts; changes in Met-enkephalin and beta-endorphin in blood and cerebrospinal fluid.
In heroin addicts showing features of heroin withdrawal basal beta-endorphin levels were elevated in both blood and cerebrospinal fluid (CSF) and did not change during electroacupuncture, although this therapy suppressed the clinical features of withdrawal. Met-enkephalin levels were not elevated in blood or CSF before treatment. However, successful electroacupuncture was associated with a rise in CSF met-enkephalin levels in all patients studied, although concentrations in blood did not alter.
D015670:Acupuncture Therapy; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000134:cerebrospinal fluid; D000328:Adult; D000941:Antigens; D004723:Endorphins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004745:Enkephalins / Q000097:blood / Q000134:cerebrospinal fluid; D006556:Heroin Dependence / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008715:Methionine / Q000097:blood; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D008083:beta-Lipotropin / Q000097:blood / Q000134:cerebrospinal fluid
D000941:Antigens; D004723:Endorphins; D004745:Enkephalins; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin; D008715:Methionine; D006854:Hydrocortisone