The impact of HLA-A, B or HLA-D identity on the MIF production in MLC.
The relative influence on MIF release in MLC of different parts of the HLA region was studied in 1) MLCs between cells from HLA-A and B identical (probably HLA-D unidentical) unrelated persons and 2) MLCs between cells from HLA-D identical, HLA-A and B unidentical unrelated persons. It was found that the HLA-D part of the region has the major effect on the MIF production. Studies of MIF activity in supernatants from mitomycin treated cultures lent some evidence to the hypothesis that there is an extreme linkage disequilibrium between the HLA-D alleles and hypothetical separate MIF alleles. Examination of families with crossover between the HLA-A, B and HLA-D part of the region is required for confirmation of these findings.
D000939:Epitopes; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D008937:Mitomycins / Q000494:pharmacology
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D008263:Macrophage Migration-Inhibitory Factors; D008937:Mitomycins