Does bile promote extra-colonic cancer?
The incidence of biliary-tract cancer and of several other gastrointestinal tumours is increased when conditions favour conversion of bile acids to more active substances. This may indicate that bacterial degradation of bile salts is related to the pathogenesis of cancer in parts of the alimentary tract other than the large bowel.
D001646:Bile / Q000378:metabolism / Q000382:microbiology; D001647:Bile Acids and Salts / Q000378:metabolism*; D001650:Bile Duct Neoplasms / Q000209:etiology* / Q000378:metabolism; D001660:Biliary Tract Diseases / Q000150:complications; D003013:Clostridium / Q000378:metabolism; D003110:Colonic Neoplasms / Q000209:etiology / Q000378:metabolism; D005706:Gallbladder Neoplasms / Q000209:etiology* / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism; D007421:Intestine, Small
D001647:Bile Acids and Salts