title: Changes of vasopressin in hypertension: Cause or effect?
abstract: Plasma concentrations of arginine-vasopressin (antidiuretic hormone) have been measured in 40 patients with benign essential hypertension and 12 patients with malignant-phase hypertension. Values tended to be low in the benign phase and high in the malignant phase. 5 normal subjects were infused with synthetic arginine-vasopressin, producing plasma concentrations up to five times the highest value recorded in malignant-phase hypertension, without any effect on blood-pressure. There is no evidence that vasopressin has a direct role in the pathogenesis of benign essential hypertension or its transition to the malignant phase. On the contrary, abnormal vasopressin concentrations may be caused by hypertension.
mesh_terms: D000328:Adult; D000368:Aged; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D006974:Hypertension, Malignant / Q000097:blood; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D014667:Vasopressins / Q000031:analogs & derivatives*
chemical_list: D014667:Vasopressins; D001127:Arginine Vasopressin