Specific inhibition of formation of acid-fastness in mycobacteria by 3,3'-di-O-methylellagic acid.
3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibited the formation of acid-fastness in mycobacteria without retardation of their growth. Gross reductions in contents of wax D, cord factor and free mycolic acids were found in the nonacid-fast bacilli compared with the normal ones.
D000143:Acids; D001578:Benzopyrans / Q000494:pharmacology*; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects* / Q000254:growth & development; D013194:Staining and Labeling; D013997:Time Factors
D000143:Acids; D001578:Benzopyrans; D004610:Ellagic Acid