Demonstration of HLA restricted killer cells in patients with acute measles.
The relationship between HLA determinants on effector and target cells and cell-mediated cytotoxicity was studied using the release of 51Cr from measles virus-infected PHA-blasts. HLA compatibility between effector and target cells was not required if effector lymphocytes were derived from measles seropositive adults, from a patient with SSPE, and from children after live measles vaccination. Cytotoxicity was always abolished after removal of Fc receptor-bearing lymphoid cells. In these donors, the effect is, therefore, probably due to K cells. In contrast, lymphocytes from children with acute measles preferentially killed those virus-infected target cells with which they shared HLA antigens. Selective lytic activity was still observed after elimination of Fc receptor-bearing lymphoid cells. It is suggested that HLA-dependent killer cells represent specific cytotoxic T lymphocytes. These cells seem to be limited to the acute phase of measles.
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D006680:HLA Antigens; D006648:Histocompatibility; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008457:Measles / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology
D000939:Epitopes; D006680:HLA Antigens; D007141:Immunoglobulin Fc Fragments; D010835:Phytohemagglutinins