Behaviour in ferrets of swine influenza virus isolated from man.
After intranasal instillation into ferrets, the "swine" influenza virus A/New Jersey/8/76(Hsw1 N1) had a 50% minimal infectious dose similar to that of previously tested A/PR/8-A/England (H3 N2) recombinants virulent and attenuated for man. A/New Jersey produced only a mild upper respiratory tract infection. However, higher titres of virus were recovered from the lungs over a longer period than experienced previously with Asian and Hong Kong virus strains. There was a diphasic pyrexia the second and higher peaks of which correlated with peak titres of virus in lung macerates. These results suggest that A/New Jersey has a pneumotropic potential in ferrets and, if the animal model is valid, possible in man.
D000818:Animals; D002335:Carnivora / Q000382:microbiology*; D004195:Disease Models, Animal; D005289:Ferrets / Q000382:microbiology*; D005334:Fever / Q000150:complications / Q000382:microbiology; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification / Q000472:pathogenicity*; D007251:Influenza, Human / Q000150:complications / Q000382:microbiology*; D008168:Lung / Q000382:microbiology; D009666:Nose / Q000382:microbiology; D011024:Pneumonia, Viral / Q000209:etiology / Q000382:microbiology; D014774:Virulence