title: Heparin cofactor activity during and after extracorporeal circulation with bubble and membrane oxygenators.
abstract: Heparin cofactor activity as measured by an amidolytic method has been investigated in 48 patients undergoing cardiac surgery with extra-corporeal circulation (E.C.C.). Heparin cofactor activity is reduced soon after the start of E.C.C., due to hemodilution but it returns towards initial levels at the completion of the procedure and 3 hours later. Thus heparin cofactor does not seem to play a role in the heparin rebound phenomenon. In our patients bubble oxygenators did not modify heparin cofactor activity more than did membrane oxygenators.
mesh_terms: D000510:Alpha-Globulins / Q000378:metabolism*; D000990:Antithrombin III / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D006801:Humans; D010106:Oxygenators; D010107:Oxygenators, Membrane; D011479:Protamines / Q000494:pharmacology
chemical_list: D000510:Alpha-Globulins; D011479:Protamines; D000990:Antithrombin III