title: Acute intravenous premedication with nalbuphine.
abstract: In a randomized, double blind study of 75 adult surgical patients, nalbuphine (0.1 mg/kg), morphine (0.1 mg/kg), or a placebo were administered intravenously as premedication 12 to 16 minutes prior to induction of anesthesia. Comparison of the 3 groups showed: (1) patients receiving nalbuphine and morphine had a significant reduction of minute ventilation and a significantly greater incidence of immediate side effects than did patients receiving placebo injections; (2) patients receiving morphine required no medication for pain in the early postoperative period; and (3) patients receiving nalbulphine experienced less nausea and/or vomiting postoperatively than did those in the other 2 groups.
mesh_terms: D002584:Cervix Uteri / Q000601:surgery; D002986:Clinical Trials as Topic; D004107:Dilatation and Curettage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009019:Morphinans / Q000627:therapeutic use*; D009020:Morphine / Q000009:adverse effects / Q000627:therapeutic use; D009266:Nalbuphine / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D010166:Palliative Care; D010919:Placebos; D011229:Preanesthetic Medication
chemical_list: D009019:Morphinans; D010919:Placebos; D009020:Morphine; D009266:Nalbuphine