B- and T-cell determination in ALL.
The influence of different cytostatic treatment schemes on T- and B-cell behaviour has been studied in children with ALL and UAL. Under these treatment schemes the percentage of B-cells decreased, while the percentage of T-cells remained within normal limits. In long-term remissions, we found normal values. In the first attack of ALL before therapy, a different behaviour of lymphoid cells was found. One group of patients had no lymphoid cells with membrane-bound Ig and no rosette forming cells; a second group had mainly T-cells, and a third group showed normal values of lymphoid cells with membrane-bound Ig, but the ability of rosette formation was slightly diminished. Whether this membrane-bound Ig is really cell-produced or only attached to the cell-membrane (blocking antibodies?) is discussed. Capping and pitching behaviour was observed. There were no differences in cell-membrane fluidity as compared with the normal controls.
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000939:Epitopes