Role of cyclic GMP in submandibular gland secretion.
Cholinergic stimulation of rat submandibular gland slices resulted in a rapid increase in the level of cyclic GMP. This increase was dependent upon the presence of Ca2+ and a phosphodiesterase inhibitor. Adrenergic agonists did not produce a significant elevation of cyclic GMP. The addition of Ca2+ to slices preincubated with the divalent ionophore A23187 caused a rapid rise in cyclic GMP levels which were unaffected by cholinergic stimulation. While these results could support a function for cyclic GMP in cholinergic-mediated K+-release from these glands, they do not support a role for this nucleotide in alpha-adrenergic agonist-induced K+-release or protease secretion.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D006152:Cyclic GMP / Q000096:biosynthesis*; D004533:Egtazic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013363:Submandibular Gland / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology
D010277:Parasympathomimetics; D013566:Sympathomimetics; D000001:Calcimycin; D004533:Egtazic Acid; D002217:Carbachol; D006152:Cyclic GMP; D002118:Calcium; D015056:1-Methyl-3-isobutylxanthine