Increased HLA-B heterozygosity with age.
427 healthy individuals ranging in age from 16 to 101 years were tested for HLA-A and -B antigens. No significant differences were found for any particular antigen according to the age of the individual. However, a significant trend of increasing frequency with age was found for individuals possessing two detectable HLA-B antigens. An apparent trend of increasing frequencies for individuals possessing four HLA-A and -B antigens was not significant. These results concur with those of some previously published studies.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000939:Epitopes; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged
D000939:Epitopes; D006680:HLA Antigens