A methodology for the production of carbohydrate-specific antibody.
8-Methoxycarbonyloctyl glycosides are recommended as precursors for the preparation of artificial antigens that possess strongly immunodominant carbohydrate antigenic determinants. The preparation and immunochemical properties of a selected number of these antigens are reported to demonstrate the high levels of hapten-specific antibodies that are normally achieved using standard immunization schedules. The method, based on glycoside synthesis, promises to make available a wide spectrum of well defined antigens and the homologous antibodies.
D000818:Animals; D000917:Antibody Formation; D002241:Carbohydrates / Q000276:immunology*; D000939:Epitopes; D006027:Glycosides / Q000276:immunology; D006241:Haptens; D005779:Immunodiffusion; D011233:Precipitin Tests; D011817:Rabbits / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000276:immunology
D002241:Carbohydrates; D000939:Epitopes; D006027:Glycosides; D006241:Haptens; D012710:Serum Albumin, Bovine