An in-vitro study of acidosis, platelet function, and perinatal cerebral intraventricular haemorrhage.
Platelet aggregation in response to adenosine diphosphate was studied in umbilical-vein blood from 24 term infants. The pH of platelet-rich plasma was experimentally reduced by adding increasing concentrations of lactic acid or by exposure to carbon dioxide. Aggregation was significantly impaired by acidosis and there was a significant positive correlation between falling pH and impaired platelet aggregation in both experiments. Impaired platelet aggregation secondary to acidosis may be a factor in perinatal intracerebral haemorrhage.
D000138:Acidosis / Q000097:blood*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D001794:Blood Pressure; D001810:Blood Volume / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D007773:Lactates / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood
D007773:Lactates; D002245:Carbon Dioxide; D000244:Adenosine Diphosphate