title: Toxic effects of dental amalgam implants. Optical histological and histochemical observations.
abstract: Dental amalgam and porcelain control discs were implanted in the subcutaneous tissue of rats. Amalgam implants exerted a toxic effect caused by release of metal ions which was characterized by prolonged inflammation, delayed granulation and disordered collagen formation. Dental porcelain was found to be a suitable biocompatible control which provided a bulk similar to that of dental amalgam but induced only an uncomplicated granulation response.
mesh_terms: D000818:Animals; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D003723:Dental Amalgam / Q000009:adverse effects* / Q000378:metabolism; D003776:Dental Porcelain; D003872:Dermatitis / Q000473:pathology; D005347:Fibroblasts / Q000166:cytology; D006097:Granulation Tissue / Q000033:anatomy & histology; D051381:Rats; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D013194:Staining and Labeling
chemical_list: D003776:Dental Porcelain; D003723:Dental Amalgam; D003094:Collagen