The effect of uremia and dialysis on cell-mediated immunity.
Delayed-type hypersensitivity to PPD, two types T rosettes as well as lymphokine production were studied in patients with end-stage renal failure maintained on hemodialysis. A significant impairment of skin reactivity and the lowering of the number of T cells were found, while no definite changes of lymphokine production were detected. No conclusive data are obtained as to the role of hemodialysis in reversing of immunologic deficits noted in uremia.
D001485:Basement Membrane / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007678:Kidney Glomerulus / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis*; D006435:Renal Dialysis; D012397:Rosette Formation; D012882:Skin Tests; D014511:Uremia / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D008222:Lymphokines; D005719:gamma-Globulins