[Study of the fucose-rich oligosaccharides in the urine of healthy and melituric subjects with A, B and O blood groups].
The application of adsorption chromatography on charcoal-Celite leads the authors to characterize in normal urines a class of fucose-rich oligosaccharides which possess blood group activities and are related to the phenotypes ABH, Le and secretor. Most of these oligosaccharides have a glucose residue in reducing terminal positions. Excretion of some oligosaccharides increases in the urine of diabetic and lactosuric subjects. In spontaneous or induced galactosurias, the elimination of oligosaccharides with a glucose residue in reducing terminal position decreases while appears a large amount of new oligosaccharides which all possess a galactose residue in reducing terminal position. These results lead to the conclusion that urinary oligosaccharides do not originate from glycosphingolipids, but from transglycosylation on carbohydrates which exist free in the organism: glucose for normal and diabetic subjects, lactose or galactose for lactosuric and galactosuric subjects, respectively.
D000017:ABO Blood-Group System; D002845:Chromatography; D002854:Chromatography, Paper; D003920:Diabetes Mellitus / Q000652:urine; D000939:Epitopes; D005260:Female; D005643:Fucose / Q000652:urine*; D005690:Galactose / Q000652:urine; D005693:Galactosemias / Q000652:urine; D006029:Glycosuria / Q000652:urine*; D006801:Humans; D007785:Lactose / Q000652:urine; D007983:Lewis Blood Group Antigens; D008297:Male; D008970:Molecular Weight; D009844:Oligosaccharides / Q000652:urine*
D000017:ABO Blood-Group System; D000939:Epitopes; D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; D005643:Fucose; D007785:Lactose; D005690:Galactose
Etude des oligosaccharides riches en fucose présents dans les urines de sujets sains et mélituriques de groupes sanguins A, B et O