Correlated inhibition of ribosomal RNA synthesis and silver staining by actinomycin D.
Preferential inhibition of the synthesis of ribosomal RNA by low doses of actinomycin D was used to investigate the quantitative relationship between the intensity of silver staining of nucleoli and the rate of RNA-synthesis. The two parameters were found to be strongly correlated in human diploid fibroblasts.
D002466:Cell Nucleolus / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D012335:RNA, Ribosomal / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012836:Silver Proteins; D013194:Staining and Labeling
D012335:RNA, Ribosomal; D012836:Silver Proteins; D003609:Dactinomycin