Myopathy in Whipple's disease.
We report a patient with Whipple's disease who developed a myopathy that improved during antibiotic therapy. The muscle biopsy showed mild type 2 fibre atrophy, type 1 fibre preponderance, variability in fibre size, and changes in the myofibrillar pattern of affected fibres. Interfascicular macrophages contained PAS-positive material. With the electron microscope these macrophages contained membranous inclusions and bacillary bodies, similar to those seen in the jejunal biopsy.
D001706:Biopsy; D006801:Humans; D007583:Jejunum / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000648:ultrastructure; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology; D008061:Whipple Disease / Q000150:complications* / Q000473:pathology