Is pancreatic polypeptide a marker for Zollinger-Ellison syndrome?
Basal human pancreatic polypeptide (H.P.P.) concentrations have been measured in 41 pateints with Zollinger-Ellison syndrome (Z.E.S.) and in 100 controls. Basal H.P.P. concentrations in controls varied widely from less than 8 pmol/l (assay detection limit) to 313 pmol/l. In controls, but not in the Z.E.S. patients, there was a highly significant positive correlation between basal H.P.P. and age (P less than 0.01). 4 of the Z.E.S. patients (9.8%) and 3 of the controls (3%) had H.P.P. concentrations over 240 pmol/l. These findings indicate that raised basal H.P.P. concentration is an infrequent finding in patients with gastrinomas and therefore it is not a useful tumour marker.
D000328:Adult; D005755:Gastrins / Q000097:blood / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010187:Pancreatic Hormones / Q000097:blood* / Q000378:metabolism; D010455:Peptides / Q000097:blood* / Q000378:metabolism; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism
D005755:Gastrins; D010187:Pancreatic Hormones; D010455:Peptides