Antibiotic-induced colitis implication of a toxin neutralised by Clostridium sordellii antitoxin.
A toxin(s) has been demonstrated in the stools of two patients with antibiotic-associated colitis. This toxin(s) was heat-labile, was rapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against other clostridia; Escherichia coli, and Vibrio cholerae toxins. These characteristics were identical to those of a toxin implicated in the aetiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.
D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D000992:Antitoxins / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000633:toxicity; D003013:Clostridium; D006224:Cricetinae; D046508:Culture Techniques; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011817:Rabbits; D013530:Surgical Wound Infection / Q000517:prevention & control; D014552:Urinary Tract Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000992:Antitoxins; D001427:Bacterial Toxins