[Modification of the immune reaction by antigen-immunosuppressive-agent conjugates. I. Tentative hypothesis for the induction of antigen-specific suppression by antigen-immunosuppressive-agent conjugates].
The most important mechanisms for the specific depression of immune reactions--immuno-tolerance, enhancement, transfer of antibodies, drug induced tolerance, immunological suicide, application of antibody-toxin-complexes--are discussed with regard to their possible application in the clinical practice. A tentative hypothesis for induction of antigen specific suppression is proposed, basing on the use of antigen-immunosuppressive agent-conjugates (AIC). Antigen binding lymphocytes are supposed to bind the AIC and to pick them up through endocytosis. After breakdown of the AIC in the lymphoid cells the free immunosuppressive agent can become effective causing damage to the specific cell clones.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D000939:Epitopes; D007108:Immune Tolerance / Q000187:drug effects; D007136:Immunoglobulins / Q000302:isolation & purification; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D007136:Immunoglobulins; D007166:Immunosuppressive Agents
Die Beeinflussung von Immunreaktionen durch Antigen-Immunsuppressivum-Konjugate. I. Arbeitshypothese zur Induktion antigenspezifischer Suppression mittels Antigen-Immunsuppressivum-Konjugaten