White platelet arterial thrombus formation is inhibited by indomethacin in vivo.
White platelet thrombi induced after electrical current application followed by ADP superfusion can be inhibited by indomethacin. These findings suggest that the synthesis of PGG2 and PGH2 is inhibited, which results in less local platelet aggregating activity.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D011453:Prostaglandins / Q000097:blood
D011453:Prostaglandins; D000244:Adenosine Diphosphate; D007213:Indomethacin