Failure to detect mouse species-specific antigens in Toxoplasmin Sevac.
Toxoplasmin--a highly purified extract from the protozoa Toxoplasma gondii propagated in mice--was tested for the presence of the mouse species-specific antigens by immunodiffusion in agar gel and by PCA test. Neither test gave positive reaction. It was concluded therefore that Toxoplasmin Sevac used for the detection of dermal hypersensitivity to toxoplasma antigens in humans does not contain any detectable contamination by mouse species-specific antigens within the limits of sensitivity of both methods used.
D000818:Animals; D000941:Antigens / Q000032:analysis* / Q000276:immunology; D000939:Epitopes; D006168:Guinea Pigs; D005779:Immunodiffusion; D051379:Mice / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis; D013045:Species Specificity; D014122:Toxoplasma / Q000254:growth & development / Q000276:immunology*
D000941:Antigens; D000939:Epitopes