title: Split unresponsiveness to trinitrophenyl (TNP) determinant. Suppression of anti-TNP antibody responses by sensitization with picryl chloride.
abstract: Contact sensitization by epicutaneous application of picryl chloride causes in mice a significant reduction of the antibody responses to immunogenic TNP-conjugates. This split unresponsiveness is along-lasting. It was found that hapten applied on the skin became attached to the serum proteins and the transfer of such a serum into normal recipients, while not influencing the ability of these animals to become contact-sensitized to PCl, rendered them unable to mount the anti-TNP antibody response. Possible mechanisms of split unresponsiveness to the TNP determinant induced by PCl treatment are suggested.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D003877:Dermatitis, Contact / Q000276:immunology; D000939:Epitopes; D005260:Female; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009578:Nitrobenzenes / Q000276:immunology*; D010853:Picryl Chloride / Q000276:immunology*; D012882:Skin Tests; D013997:Time Factors; D014301:Trinitrobenzenes / Q000276:immunology*
chemical_list: D000939:Epitopes; D009578:Nitrobenzenes; D014301:Trinitrobenzenes; D010853:Picryl Chloride