[Schizophrenia: association of the paranoid form and antigens HLA-A9 and B5].
30 unrelated Schizophrenic patients (15 Hebephrenic and 15 Paranoïd forms) were Typed for 14 A and 16 B Specificities by microlymphocytotoxicity. We note: 10 (5H + 5P) HLA--A1 (33.3 % / controls 23.4 %) 5 (2H + 3P) HLA--A3 (16.6 % / controls 26.2 %) 6 (5H + 1P) HLA--B8, 0 HLA--B27, 0 HLA BW16 and more specially: 10 (3H + 7P) HLA--A9 (23 + 24) 8 (2H + 6P) HLA--B5 These two last antigens are more often found in the Paranoïd patients of whom 46.6% are A9 Tcontrols: 24 %) and 40 % are B5 (controls 13.2 %. The Pc values are not significant in these too short seria but the strongly increased frequencies of A9 and B5 in the Paranoïd group seem to open a new biological aspect in the nosographic distinction of the Schizophrenia and so confirm previous results of C. L. CAZZULLO et al.
D000939:Epitopes; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D012562:Schizophrenia, Disorganized / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000235:genetics*
D000939:Epitopes; D006680:HLA Antigens; D006649:Histocompatibility Antigens
Schizophrénie: association de la forme paranoïde aux antigènes HLA-A9 et B5.