Delay in the development of the allergic response to metals following intratracheal instillation.
Intracheal intubation with the soluble metal salts potassium dichromate (K2Cr2O7) and nickel sulphate (NiSO4) causes a delay of up to 8 weeks in the development of delayed hypersensitivity to the specific agent. It is suggested that absorption of sensitizers by the respiratory route may, under certain circumstances, induce a state of specific immunological unresponsiveness, rather than necessarily lead to the development of a state of allergic sensitivity.
D000818:Animals; D002840:Chromates / Q000008:administration & dosage*; D000939:Epitopes; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology; D007442:Intubation, Intratracheal; D008297:Male; D009532:Nickel / Q000008:administration & dosage*; D009787:Occupational Medicine; D011192:Potassium Dichromate / Q000008:administration & dosage*; D013431:Sulfates / Q000008:administration & dosage
D002840:Chromates; D000939:Epitopes; D013431:Sulfates; D009532:Nickel; D011192:Potassium Dichromate