title: Schizophrenia: Reconciliation of the dopamine, prostaglandin, and opioid concepts and the role of the pineal.
abstract: In recent years it has been suggested that the biological defect in schizophrenia may be related to excess dopamine activity, to production of an abnormal opioid or a normal opioid in excess, to a prostaglandin deficiency, to a hypersensitivity to wheat proteins, to an allergic phenomenon, to a defect in zinc metabolism, or to a pineal deficiency. The present hypothesis proposes that the various concepts are not mutually exclusive but represent different aspects of the same problem. The final common path in schizophrenia may be a failure of formation and action of prostaglandins of the 1 series.
mesh_terms: D000485:Allergens; D004298:Dopamine / Q000378:metabolism*; D004723:Endorphins / Q000096:biosynthesis*; D004745:Enkephalins / Q000096:biosynthesis*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D008550:Melatonin / Q000172:deficiency*; D010870:Pineal Gland / Q000378:metabolism*; D010940:Plant Proteins / Q000009:adverse effects; D011458:Prostaglandins E / Q000172:deficiency*; D012559:Schizophrenia / Q000209:etiology*; D014908:Triticum / Q000009:adverse effects; D015032:Zinc / Q000172:deficiency
chemical_list: D000485:Allergens; D004723:Endorphins; D004745:Enkephalins; D010940:Plant Proteins; D011458:Prostaglandins E; D015032:Zinc; D008550:Melatonin; D004298:Dopamine