Sequential release of histamine and 5-hydroxytryptamine during pinnal anaphylaxis in the mouse.
Histamine and 5-HT have been demonstrated to be involved in pinnal anaphylaxis in mice. Each predominates at different stages during the 30-min development of the reaction. The main mediator of the early stage of the reaction (0-10 min) is histamine, that of the middle stage (10-20 min) is 5-HT, and that of the final 20- to 30-min stage is, again, histamine. The source and mechanism of release of the 5-HT and the late histamine are, as yet, unknown but under investigation.
D000707:Anaphylaxis / Q000378:metabolism*; D004423:Ear; D006636:Histamine Release; D008784:Methysergide / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*; D012867:Skin / Q000276:immunology; D013997:Time Factors
D012701:Serotonin; D011738:Pyrilamine; D008784:Methysergide