title: Reversible insensitivity to androgens in men with untreated gluten enteropathy.
abstract: Plasma androgen and gonadotrophin concentrations have been measured before and during treatment of 23 men with gluten enteropathy. Before treatment, there was marked rise in total plasma-testosterone, free testosterone concentration (as assessed by the free testosterone index), and plasma-luteinising-hormone concentration. In contrast, 5 alpha-dihydrotestosterone concentrations were lower than normal. All these abnormalities reverted towards normal with successful treatment of the jejunal mucosal lesion. These data are consistent with a reversible tissue resistance to circulating plasma-testosterone in men with gluten enteropathy and subtotal villous atrophy.
mesh_terms: D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000097:blood* / Q000178:diet therapy / Q000209:etiology; D003424:Crohn Disease / Q000097:blood; D013196:Dihydrotestosterone / Q000097:blood*; D005983:Glutens / Q000009:adverse effects; D006801:Humans; D007583:Jejunum / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000097:blood*; D013739:Testosterone / Q000097:blood*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D005983:Glutens; D007986:Luteinizing Hormone