title: One-hour blood-xylose test in diagnosis of cow's milk protein intolerance.
abstract: In this prospective study, 18 consecutive children suspected of cow's milk protein intolerance (C.M.P.I.) on clinical grounds were investigated before and after challenge with cow's milk. One-hour blood-xylose, serum-IgE, eosinophil count, serum-complement (C3) and a jejunal biopsy specimen for histology and disaccharidase activity were obtained from all patients before challenge. Serum-complement was measured again 24 h after the beginning of the challenge and the first three tests were repeated on the fifth day. A second jejunal biopsy was obtained in 9 of the first 10 children. 15 of the 18 children were considered to have C.M.P.I. The one-hour blood-xylose test emerged as a simple and valuable test in the diagnosis of C.M.P.I. A significant drop (51--81%) in the one-hour blood-xylose level was observed in all 15 patients. In all patients but one it dropped below 25 mg/dl. Mean value (+/- S.D.) for the group was 47.5 +/- 11.1 mg/dl before and 17.2 +/- 4.2 mg/dl after cow's milk ingestion.
mesh_terms: D000818:Animals; D002417:Cattle; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D004186:Disaccharidases / Q000097:blood; D004804:Eosinophils / Q000473:pathology; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D007583:Jejunum / Q000473:pathology; D007958:Leukocyte Count; D008286:Malabsorption Syndromes / Q000175:diagnosis* / Q000276:immunology; D008894:Milk Proteins / Q000009:adverse effects*; D011446:Prospective Studies; D013997:Time Factors; D014994:Xylose / Q000097:blood
chemical_list: D003176:Complement C3; D008894:Milk Proteins; D007073:Immunoglobulin E; D014994:Xylose; D004186:Disaccharidases