Fatal graft-versus-host disease following transfusion of granulocytes from normal donors.
A case of fatal graft-versus-host disease was seen in an adult with acute leukaemia, after transfusion of leucocytes from normal donors. This is the first reported case of graft-versus-host disease following transfusion of normal blood-products to a patient with a disease not usually associated with severe immunoincompetence. The number of lymphocytes transfused was no higher than that given when platelet concentrates are prepared from a single donor.
D006086:Graft vs Host Disease / Q000209:etiology / Q000401:mortality / Q000473:pathology; D006087:Graft vs Host Reaction; D006098:Granulocytes; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D007962:Leukocytes; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D065227:Transfusion Reaction