Rosette-forming mast cells in rat anaphylaxis. Immunological characteristics of mast cell rosettes.
Peritoneal mast cells from immunized rats can form rosettes with antigen-coated sheep red blood cells. The receptor responsible for this active rosette formation is shown to be IgE cytophilic antibody: rosettes are inhibited by previous contact of mast cells with antigen, or with anti-IgE antiserum; the kinetics of mast cell rosettes following a primary immunization with ovalbumin and Bordetella pertussis vaccine is similar to the kinetics of reaginic antibody response. Furthermore, a reaginic serum can induce passive rosette formation. There is no correlation between cell-bound and circulating IgE.
D000818:Animals; D005260:Female; D006636:Histamine Release; D007106:Immune Sera; D007114:Immunization; D007073:Immunoglobulin E; D007700:Kinetics; D008407:Mast Cells / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D012397:Rosette Formation; D014357:Trypsin / Q000494:pharmacology
D007106:Immune Sera; D007073:Immunoglobulin E; D010047:Ovalbumin; D014357:Trypsin