Contamination of human melanoma cell lines by mouse L cells.
Five of 8 cell lines from human melanomas originally established elsewhere were found to consist exclusively of mouse cells when examined in our laboratory some months after their receipt. Cytogenetic studies, including G- and C-banding, showed that the mouse cells in all cultures had originated from a single cell line, identified as the L-line. Contamination probably occurred, one year before its discovery, in a laboratory where L cells and human melanoma cells were briefly kept in the same incubator.
D000818:Animals; D002460:Cell Line; D002875:Chromosomes / Q000032:analysis; D002877:Chromosomes, Human / Q000032:analysis; D006801:Humans; D007739:L Cells; D008545:Melanoma; D051379:Mice; D013194:Staining and Labeling