Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes.
During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2d) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2d alloantisera throughout the transplantation cycle.
D000818:Animals; D000937:Antigen-Antibody Reactions; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005260:Female; D006183:H-2 Antigens; D007518:Isoantibodies; D008297:Male; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000939:Epitopes; D006183:H-2 Antigens; D007518:Isoantibodies