title: Hyponatraemic hypertensive syndrome with renal-artery occlusion corrected by captopril.
abstract: Malignant hypertension with severe hyponatraemia, hypokalaemia, depletion of sodium and potassium, and elevated blood levels of renin, angiotensin I, angiotensin II, aldosterone, and arginine vasopressin developed in a woman with renal-artery occlusion. Plasma angiotensin II was disproportionately high in relation to exchangeable sodium. Captopril, by inhibiting conversion of angiotensin I to angiotensin II, further elevated the blood levels of renin and angiotensin I but corrected all other abnormalities. Unilateral nephrectomy was subsequently curative.
mesh_terms: D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000097:blood; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy*; D007010:Hyponatremia / Q000188:drug therapy*; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011392:Proline / Q000031:analogs & derivatives*; D012078:Renal Artery Obstruction / Q000503:physiopathology*; D012083:Renin / Q000097:blood; D013577:Syndrome
chemical_list: D000804:Angiotensin II; D001127:Arginine Vasopressin; D000450:Aldosterone; D000803:Angiotensin I; D011392:Proline; D002216:Captopril; D012083:Renin; D011188:Potassium