[Immunosuppressive effect of a human serum ferroprotein of hepatic origin: alpha-2-HF-globulin].
alpha 2HF, a serum  ferroprotein increased during some malignant diseases, displays a suppressive effect on in vitro antibody responses, whether T-independent or T-dependent. This effect is not related to the presence of iron, nor to the macroglobulin nature of the molecule. The immunosuppressive properties of alpha 2 HF might depend on its carbohydrate moeity.
D000178:Acrylamides / Q000276:immunology; D000510:Alpha-Globulins / Q000302:isolation & purification / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects*; D001059:Apoproteins / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005293:Ferritins / Q000494:pharmacology; D006801:Humans; D007165:Immunosuppression Therapy; D008099:Liver / Q000032:analysis; D008667:Metalloproteins; D008970:Molecular Weight; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology
D000178:Acrylamides; D000510:Alpha-Globulins; D001059:Apoproteins; D008667:Metalloproteins; D014301:Trinitrobenzenes; D005293:Ferritins
Effet immunosuppresseur d'une ferroprotéine sérique humaine d'origine hépatique l'alpha 2 HF-globuline. Action sur la synthèse des anticorps in vitro