Possible virus in schizophrenia and some neurological disorders.
Cerebrospinal fluid from 13 of 38 patients with schizophrenia had a cytopathic effect in cultures of MRC5 cells. The cytopathic agent passed a 100 nm but not a 50 nm filter and was unaffected by heat at 56 degrees C for 30 min, treatment with chloroform, or the presence in cultures of bromodeoxyuridine. The agent could not be propagated serially in a satisfactory manner but its properties were those of a virus. A similar cytopathic effect was induced by cerebrospinal fluid from 8 of 11 patients with serious or chronic nervous system disease but only 1 of 25 patients with surgical or general medical conditions.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003588:Cytopathogenic Effect, Viral; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D000882:Haplorhini; D006367:HeLa Cells / Q000166:cytology; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid / Q000209:etiology; D007668:Kidney / Q000166:cytology; D008168:Lung / Q000166:cytology; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology*; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000209:etiology*; D014777:Virus Diseases / Q000150:complications*; D014713:Viruses, Unclassified / Q000302:isolation & purification