Renin lowers blood-pressure.
The hypothesis that increased plasma-renin tends to lower blood-pressure is proposed. Binding of renin to blood-vessel walls is postulated to have some vasodilator action which would oppose the usual blood-pressure-raising action caused by generation of angiotensin. Many of the effects of saralasin and of converting-enzyme inhibitor on blood-pressure in relation to concentrations of renin in blood plasma and in the kidneys seem to support this hypothesis.
D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000502:physiology; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D007610:Kallikreins / Q000502:physiology; D007668:Kidney / Q000378:metabolism; D051379:Mice; D051381:Rats; D012083:Renin / Q000097:blood / Q000172:deficiency / Q000502:physiology*; D012504:Saralasin / Q000502:physiology; D013722:Teprotide / Q000494:pharmacology; D014665:Vasodilator Agents
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D000804:Angiotensin II; D013722:Teprotide; D007610:Kallikreins; D012083:Renin; D012504:Saralasin