Suppressor T cells and suppressor factor.
The ability to suppress antibody response to specific antigens has been found to be inherent in a subpopulation of T lymphocytes. The suppressor pathway has been shown to involve an initial T-cell clone that that elaborates a soluble factor which, in turn, induces a second cohort of effector cells. The implications of this system for autoimmune and neoplastic diseases--and some relevant experiments--are discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002352:Carrier Proteins; D003520:Cyclophosphamide / Q000494:pharmacology; D000939:Epitopes; D006649:Histocompatibility Antigens; D007106:Immune Sera / Q000494:pharmacology; D007108:Immune Tolerance; D007694:Killer Cells, Natural; D008211:Lymphocyte Cooperation; D051379:Mice; D008815:Mice, Inbred Strains; D009369:Neoplasms / Q000276:immunology; D013489:Suppression, Genetic; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D002352:Carrier Proteins; D000939:Epitopes; D006649:Histocompatibility Antigens; D007106:Immune Sera; D003520:Cyclophosphamide