title: Coumarin-induced abnormal factor IX: an immunological study in humans.
abstract: An excess of factor IX antigen or protein with respect to factor IX activity is present in coumarin treated patients. The average factor IX antigen value found in a group of 16 patients was 96.2 (S.D. = 24.46) whereas the average clotting activity was 19 (S.D. = 4.54) (p less than 0.001). In the electroimmunoassay system a normal peak or precipitate were seen in every instance. In haemophilia B--no peak or precipitate were seen. The coumarin induced abnormal factor IX shows a more anodic migration in the bidimensional immunoelectrophoresis system as compared with the normal counterpart. On the contrary, the factor IX protein present in haemophilia BM or in haemophilie B+ migrates as normal factor IX.
mesh_terms: D000941:Antigens / Q000032:analysis*; D003374:Coumarins / Q000009:adverse effects*; D005164:Factor IX / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007106:Immune Sera
chemical_list: D000941:Antigens; D003374:Coumarins; D007106:Immune Sera; D005164:Factor IX