Investigation of biological activity of antigen--immunosuppressive drugs conjugates.
The influence of conjugate 6MP with bovine gamma-globulin on some cellular immunologic reactions was investigated. The animals were immunized with the protein carrier and then conjugate or its components, in not coupled form, were introduced. Selective, but not strong, suppression of the immunological answer was observed in the migration inhibition of the mice splenocytes and the foot pad test. Conjugate was not changing the activity of the factor increasing vascular permeability. It was also confirmed, that conjugates of the nonsteroidal antiinflammatory drugs, except for conjugate of phenylbutazone with HSA, were not different in its influence (in the hyperaemic and oedema tests) from the individual components in not coupled form.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000941:Antigens; D002199:Capillary Permeability; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D012709:Serum Albumin / Q000276:immunology; D005719:gamma-Globulins / Q000276:immunology
D000893:Anti-Inflammatory Agents; D000941:Antigens; D007166:Immunosuppressive Agents; D012709:Serum Albumin; D005719:gamma-Globulins; D015122:Mercaptopurine