Reciprocal 8;14 translocation in EBV-negative B-cell acute lymphocytic leukemia with Burkitt-type cells.
A cytogenetic study, including prophase-prometaphase chromosome analysis, of a patient with EBV-genome-negative acute lymphocytic leukemia of B-cell type with Burkitt-type cells is presented. All bone-marrow mitoses examined had a 14q+ marker chromosome which was identified as a reciprocal 8;14 translocation of exactly the same type as in Burkitt's lymphoma.
D000956:Antigens, Viral; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000235:genetics; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D004279:DNA, Viral; D000939:Epitopes; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011418:Prophase; D011947:Receptors, Antigen, B-Cell; D014178:Translocation, Genetic
D000956:Antigens, Viral; D004279:DNA, Viral; D000939:Epitopes; D011947:Receptors, Antigen, B-Cell