title: [Effect of cooling and electrical stimulation of nuclei of raphe system on states of alertness in cat].
abstract: In cats prepared in a 'semi-chronic' manner (spinal cord transected, brachial plexus sectioned bilaterally) all states of alertness are present; their quantitative evolution is characterized by an immediate postoperative period with continuous wakefulness and a secondary period of recovery of the states of sleep, which are then maintained. In such a preparation, localized moderate cooling (+10 degrees C) of the nucleus raphe dorsalis induces slow wave sleep and paradoxical sleep; the same type of cooling of the nucleus raphe magnus induces wakefulness; however, the electrical stimulation of these two nuclei always induces wakefulness. Cooling of the nuclei raphe centralis or pontis suppresses only the 'ponto-geniculo-occipital' (PGO) waves. Colling of the nuclei raphe obscurus and pallidus induces wakedfulness, but stage I of slow wave sleep may occur. Treatment with p-chlorophenylalanine (PCPA) before making the semi-chronic preparation produces the classical syndrome characterized by cortical activation and continuous discharge of PGO waves; in this case cooling of the nucleus raphe dorsalis no longer induces slow wave sleep but only paradoxical sleep; after injection of DL-5-HTP, slow wave sleep is obtained again through cooling; this effect diminishes progressively.
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology*; D002415:Cats; D003080:Cold Temperature; D003344:Cortical Synchronization; D004558:Electric Stimulation; D010134:Fenclonine / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D006916:5-Hydroxytryptophan; D010134:Fenclonine
vernacular_title: Effets du refroidissement et de la stimulation des noyaux du systeme du raphe sur les etats de vigilance chez le chat.