Pathogenesis and phenotypes of an X-linked recessive lymphoproliferative syndrome.
A new X-linked recessive lymphoproliferative syndrome has variable phenotypes: fatal infectious mononucleosis (I.M.), agammaglobulinaemia after I.M., American Burkitt's lymphoma, histiocytic lymphoma, immunoblastic sarcoma of B cells, or plasmacytoma. An immunodeficiency to rubeola and the Epstein-Barr virus probably ensues from the mutant gene. The phenotypes (spectrum of B-cell disorders) have a common inheritance and the aetiology is similar.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000209:etiology / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007223:Infant; D007244:Infectious Mononucleosis / Q000209:etiology / Q000235:genetics; D008223:Lymphoma / Q000209:etiology / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology; D008297:Male; D010641:Phenotype; D010954:Plasmacytoma / Q000209:etiology / Q000235:genetics; D012509:Sarcoma / Q000209:etiology / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000150:complications; D013577:Syndrome