Forebrain projections of the ventral tegmentum as studied by axonal transport of [3H]dopamine in the rat.
Twenty-four hours after [3H]dopamine ([3H]DA) injections into different parts of the ventral tegmentum the radioactivity recovered in the forebrain showed a highly regional distribution which corresponded to well-known DA projections. Selective degeneration of DA-neurons with 6-hydroxydopamine (6-OHDA) markedly reduced the axoplasmic transport after [3H]DA injections. The ventral tegmental area (VTA) was found to project primarily to the nucleus accumbens, olfactory tubercle and amygdala. The DA-innervation of the entorhinal cortex and the amygdala derive from cells widely distributed in the VTA and SN.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism*; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology / Q000378:metabolism
D004298:Dopamine