Simultaneous detection of reverse transcriptase and high molecular weight RNA in tissue of patients with Hodgkin's disease and patients with leukemia.
Complexes of high-molecular-weight RNA and reverse transcriptase (RNA-dependent DNA nucleotidyltransferase) have been detected in 14(77.8%) of 18 spleen from patients with Hodgkin's disease and in all samples tested of peripheral leukocytes and spleens from leukemic patients. The enzyme and its template are localized in a particle having a density between 1.16 and 1.19 g/ml. These observations describe characteristic features of RNA tumor viruses.
D006689:Hodgkin Disease / Q000201:enzymology / Q000382:microbiology*; D006801:Humans; D007938:Leukemia / Q000201:enzymology / Q000382:microbiology*; D007962:Leukocytes / Q000382:microbiology; D008970:Molecular Weight; D012367:RNA, Viral / Q000032:analysis*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis*; D012190:Retroviridae / Q000032:analysis; D013154:Spleen / Q000382:microbiology
D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase