Electroradioimmunoassay: a sensitive method for the quantitation of alpha-fetoprotein.
A sensitive technique, electroradioimmunoassay has been adapted for the estimation of alpha1-fetoprotein in normal adult human plasma and serum. Commercially available antisera were used and a 10-fold increase in sensitivity was obtained in comparison with two conventional radioimmunoassays. Plasma alpha 1-fetoprotein levels of 2.6 +/- 1.2 microgram/1 (mean and standard deviation) were found in a normal population as compared with levels of 4.1 +/- 2.6 microgram/l in a group of 49 patients with alcoholic liver disease.
D000437:Alcoholism / Q000150:complications; D000937:Antigen-Antibody Reactions; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism; D008297:Male; D008722:Methods; D011863:Radioimmunoassay / Q000379:methods; D000509:alpha-Fetoproteins / Q000032:analysis*
D007457:Iodine Radioisotopes; D000509:alpha-Fetoproteins