A defect in catecholamine neurons in patients with prolactin-secreting pituitary adenoma.
Although basal plasma concentrations of dopamine, noradrenaline, and adrenaline in patients with prolactin-secreting pituitary adenoma are normal, responses to oral bromocriptine are not. 1 and 2 h after bromocriptine, plasma concentrations of these three catecholamines are decreased in normal men but not in patients with hyperprolactinaemia secondary to prolactin-secreting pituitary adenoma or in normoprolactinaemic patients in whom a pituitary adenoma has been removed. Patients with prolactin-secreting pituitary adenoma probably have a defect in the regulation of brain catecholamine metabolism.
D000236:Adenoma / Q000378:metabolism*; D000284:Administration, Oral; D001921:Brain / Q000473:pathology*; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology; D004298:Dopamine / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D009384:Paraneoplastic Endocrine Syndromes / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011941:Receptors, Adrenergic / Q000378:metabolism*
D011941:Receptors, Adrenergic; D001971:Bromocriptine; D011388:Prolactin; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine