Immunologic features of a carcinogen-induced murine bladder cancer: in vivo and in vitro studies.
Certain in vivo and in vitro immunologic features of carcinogen-induced murine bladder cancer have been studied. The consistency of tumor induction, its natural history, and immunogenicity both in vivo and in vitro render this syngeneic murine bladder tumor a suitable model for immunologic studies. Pre-immunization of strain C3H/Hen mice with mid-gestational fetal cells did not protect the animals from tumor challenge. Sera of mice immunized with mid-gestational fetal cells were not cytotoxic to cultured tumor cells in a microcytotoxicity assay indicative of dissimilarity between the tumor associated antigen and the syngeneic mid-gestational fetal antigen.
D000818:Animals; D000951:Antigens, Neoplasm; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005200:FANFT; D005260:Female; D005333:Fetus / Q000276:immunology; D007109:Immunity; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology; D011247:Pregnancy; D013844:Thiazoles; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000276:immunology*
D000951:Antigens, Neoplasm; D000939:Epitopes; D013844:Thiazoles; D005200:FANFT