Degradation of dermal fibrillar structures: effects of collagenase, elastase, dithioerythritol and citrate.
Clostridial collagenase, elastase, medium material of human skin culture, dithioerythritol and citrate buffer, pH 3.5, were applied to fresh human skin specimens. Phenomena of degradation of dermal fibrils were observed by electron microscopy.
D002951:Citrates / Q000494:pharmacology*; D003094:Collagen; D004226:Dithioerythritol / Q000494:pharmacology*; D004229:Dithiothreitol / Q000031:analogs & derivatives*; D004547:Elastic Tissue / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D003012:Microbial Collagenase / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure
D002951:Citrates; D004226:Dithioerythritol; D003094:Collagen; D010196:Pancreatic Elastase; D003012:Microbial Collagenase; D004229:Dithiothreitol