[Admixtures present in antitoxic horse sera and pepsin preparations].
Antitoxic therapeutic sera produced by the method "Diaferm-3" (devised at the Institute of Epidemiology and Microbiology of the USSR Academy of Medical Sciences) are contaminated in the process of production with group-specific substances and extraneous enzymes contained in crude preparations of swine pepsin. These ballast substances have a negative influence on the process of purification and the stability of antitoxin during the storage of the sera and constitute one of the reasons of their high reactogenicity.
D000818:Animals; D000941:Antigens / Q000032:analysis / Q000302:isolation & purification; D004340:Drug Contamination; D000939:Epitopes; D006736:Horses / Q000276:immunology; D007106:Immune Sera / Q000032:analysis / Q000302:isolation & purification*; D007164:Immunosorbents; D010434:Pepsin A / Q000032:analysis / Q000302:isolation & purification*; D013743:Tetanus Antitoxin / Q000032:analysis / Q000302:isolation & purification
D000941:Antigens; D000939:Epitopes; D007106:Immune Sera; D007164:Immunosorbents; D013743:Tetanus Antitoxin; D010434:Pepsin A
Izuchenie primeseĭ, prisutstvuiushchikh v antitoksicheskikh loshadinykh syvorotkakh i preparatakh pepsina.