Modulation of antigen-induced histamine release from bovine granulocytes by several anti-allergic agents.
Sensitised bovine granulocytes release histamine when exposed to antigen. Several anti-allergic agents, some previously shown to be active in cattle, were tested to investigate their modulation of this histamine release process. Diethylcarbamazine citrate potentiated release at low concentrations and inhibited at high concentrations. Sodium meclofenamate and PR-D-92-EA were potent inhibitors. Acetylsalicylic acid and ICI 74,917 inhibited at high concentrations. Disodium cromoglycate was relatively ineffective, although it potentiated histamine release at low concentrations.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology; D002417:Cattle; D004205:Cromolyn Sodium / Q000494:pharmacology; D004049:Diethylcarbamazine / Q000494:pharmacology; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism*; D008469:Meclofenamic Acid / Q000494:pharmacology; D010618:Phenanthrolines / Q000494:pharmacology
D001578:Benzopyrans; D006634:Histamine H1 Antagonists; D010618:Phenanthrolines; D008469:Meclofenamic Acid; C010685:PR-D-92; D004205:Cromolyn Sodium; D001241:Aspirin; D004049:Diethylcarbamazine