Comparison of accuracy of 99mTc-pyridoxylidene glutamate scanning with oral cholecystography and ultrasonography in diagnosis of acute cholecystitis.
A prospective study of 116 patients admitted as emergencies with a clinical diagnosis of acute cholecystitis or biliary colic has shown that the best investigation for confirming a diagnosis of acute cholecystitis is 99mTc-pyridoxylidene glutamate (PG) scanning. Its sensitivity is 99% and its specificity 86%, whereas those of oral cholecystography are 75% and 82%, respectively, and those of ultrasonography are 54% and 62%, respectively. However, estimation of plasma liver enzymes is essential to exclude acute hepatitis before proceeding to early cholecystectomy.
D000208:Acute Disease; D002764:Cholecystitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002765:Cholecystography / Q000379:methods*; D002769:Cholelithiasis / Q000175:diagnosis; D003085:Colic / Q000175:diagnosis; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D005704:Gallbladder / Q000000981:diagnostic imaging; D005971:Glutamates; D006801:Humans; D011446:Prospective Studies; D011730:Pyridoxal / Q000031:analogs & derivatives*; D011877:Radionuclide Imaging; D013667:Technetium; D014463:Ultrasonography
D005971:Glutamates; C011096:pyridoxylideneglutamate; D011730:Pyridoxal; D013667:Technetium