Isoelectric focusing of CSF proteins in known or probable infectious neurological diseases and the Guillain-Barré syndrome.
The CSF and serum proteins of 120 patients with known or probable infectious neurological diseases or the Guillain-Barré syndrome were examined with thin-layer IEF. All but two of these patients exhibited one or combinations of different CSF-protein aberrations in the acidic and alkaline range. Aberrant non-Ig fractions (including transferrin, the tau-fraction and gamma-trace protein) were found in frequencies varying between 4 and 48%. CSF Ig components of restricted heterogeneity, i.e. oligoclonal bands and/or regional increases of gamma-globulins, were more frequent in patients with (meningo-)encephalitic or (meningo-)-myelitis/radiculitic disorders (respectively 69 and 48%) than in subjects with meningitis or Guillain-Barré syndrome (17%). The occurrence of such Ig abnormalities was higher in subacute or chronic than in acute disease and in subjects examined greater than 4 weeks after the onset rather than earlier. Ig-band spectra with marked anodal extension were found predominantly in (meningo-)encephalitic disorders with infratentorial symptoms. Age and sex were not found to influence the occurrence of abnormal Ig fractions. Such components could be detected in spite of pronounced blood-CSF barrier defects.
D000328:Adult; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007239:Infections; D007525:Isoelectric Focusing; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009187:Myelitis / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid; D005719:gamma-Globulins / Q000032:analysis
D002556:Cerebrospinal Fluid Proteins; D005719:gamma-Globulins