Daily rhythm and regulation of AIB transport in rat liver.
The active transport of AIB in rat liver slices shows a daily rhythm with a maximum at 18(00) and a minimum at 10(00). The rhythmic increase of transport activity is inhibited by cycloheximide. At the time of low transport rate, cycloheximide does not affect AIB transport. During the diurnal decrease of AIB transport activity, after its maximum, cycloheximide partially diminishes the transport rate. 5-azacytidine and alpha-amanitin stimulate AIB transport. The stimulation is prevented by simultaneous administration of cycloheximide.
D000546:Amanitins / Q000494:pharmacology; D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D002940:Circadian Rhythm; D003513:Cycloheximide / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats
D000546:Amanitins; D000621:Aminoisobutyric Acids; D003513:Cycloheximide; D001374:Azacitidine