title: [Qualities and application of macromolecular volume substitutes (author's transl)].
abstract: The effective volume substitution in shock requires normalizing of the circulating blood volume as well as the restitution of microcirculation. Saline solutions are unsuited for their missed oncotic efficiency and their short intravenous staying. Also stored blood is unsuitable because of its rheological properties, plasma protein preparations for economical and infectious reasons. The different qualities and effects of the known plasma substitutes on the basis of dextran, gelatine and starch are described, their special indications being explained. Haemodilution and the so-called secondary effects limit the dosage of volume substitution.
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D003911:Dextrans / Q000627:therapeutic use; D005780:Gelatin / Q000627:therapeutic use; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D012769:Shock / Q000188:drug therapy
chemical_list: D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D005780:Gelatin
vernacular_title: Eigenschaften und Anwendung von makromolekularen Volumenersatzmitteln.