On the synthesis of serine and homoserine samples asymmetrically labelled with tritium and deuterium in the hydroxymethylene group.
(1R) [1-3H, 2H1] 3-Phenylpropanol, the key intermediate in the synthesis of (4R) [4-3H, 2H1] D,L-homoserine and of the (4S)-isomer, is obtained from (1S) [1-2H1] 3-phenylpropanol and (1RS) [1-3H] ethanol upon incubation with yeast alcohol dehydrogenase and NAD+; under similar conditions 2-phenylethanol undergoes very small exchange with [1-2H2] ethanol.
D000433:1-Propanol / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D006714:Homoserine / Q000096:biosynthesis*; D010626:Phenylethyl Alcohol / Q000378:metabolism; D020005:Propanols; D012694:Serine / Q000096:biosynthesis*
D020005:Propanols; D012694:Serine; D006714:Homoserine; D000433:1-Propanol; D000429:Alcohol Oxidoreductases; D010626:Phenylethyl Alcohol