Quantitative determinations of two decongestants and an antihistamine in combination using paired ion high-pressure liquid chromatography.
A single method for the quantitative determinations of three active ingredients, phenylephrine hydrochloride, phenylpropanolamine hydrochloride, and brompheniramine maleate, and one inactive ingredient (sodium benzoate) in a commercial product for colds is reported. The method is based on paired ion high-pressure liquid chromatography using 1-heptanesulfonic acid as the counterion. It is accurate and precise. The relative standard deviations based on six readings are reported. This method is sensitive; less than 1 microgram of each ingredient can be assayed. The peak area of each ingredient is related to its concentration.
D001977:Brompheniramine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations / Q000032:analysis; D008722:Methods; D014663:Nasal Decongestants / Q000032:analysis; D010656:Phenylephrine / Q000032:analysis*; D010665:Phenylpropanolamine / Q000032:analysis*; D011725:Pyridines / Q000032:analysis*
D004338:Drug Combinations; D014663:Nasal Decongestants; D011725:Pyridines; D010656:Phenylephrine; D010665:Phenylpropanolamine; D001977:Brompheniramine