Oncogenicity in marmosets of HL-23V, a type C oncornavirus isolated from human leukemic cells, and comparison with simian sarcoma virus type 1 (SSV-1/SSAV-1).
Type C virus produced by dog thymus cells (A7573) that were infected with virus (HL-23V), isolated from cultured leukocytes of an acute myelogenous leukemia patient, transformed marmoset and horse cells in vitro and induced virus-producing fibromas in marmosets. The tumors and transformed foci were indistinguishable morphologically from those induced by simian sarcoma virus, type 1 (SSV-1/SSAV-1). HL-23V was indistinguishable from SSV-1/SSAV-1 by immunofluorescence and neutralization tests, and the nontransforming virus associated with HL-23V completely inhibited SSV-1 focus induction in interference tests. Cell cultures established from a marmoset fibroma produced transforming and nontransforming virus biologically and antigenically indistinguishable from HL-23V and SSV-1/SSAV-1.
D000818:Animals; D000831:Animals, Newborn; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D002143:Callitrichinae; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D000939:Epitopes; D000882:Haplorhini; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology*; D009858:Oncogenic Viruses; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D012513:Sarcoma, Experimental / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D014776:Virus Cultivation
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000939:Epitopes