Evidence for a particle-associated RNA-directed DNA polymerase in rabbit placental and uterine tissues.
A RNA-directed DNA polymerase associated with particles that band at a density characteristic of type C RNA viruses was found in normal rabbit placental and uterine tissues taken during the early stages of gestation. That the rabbit RNA-directed DNA polymerase is distinct from the known cellular DNA polymerases and similar to the RNA-directed DNA polymerase of mammalian type C RNA viruses is shown by column chromatographic characteristics, template primer preferences, molecular weight determination, and an absolute requirement for the divalent cations.
D000818:Animals; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D009838:Oligodeoxyribonucleotides / Q000378:metabolism; D010920:Placenta / Q000201:enzymology* / Q000382:microbiology; D011061:Poly A / Q000378:metabolism; D011071:Poly T / Q000378:metabolism; D011119:Polynucleotides / Q000378:metabolism; D011247:Pregnancy; D012367:RNA, Viral / Q000378:metabolism; D012194:RNA-Directed DNA Polymerase / Q000302:isolation & purification*; D011817:Rabbits; D012190:Retroviridae / Q000201:enzymology*; D014599:Uterus / Q000201:enzymology* / Q000382:microbiology
D009838:Oligodeoxyribonucleotides; D011119:Polynucleotides; D012367:RNA, Viral; D011061:Poly A; D011071:Poly T; D012194:RNA-Directed DNA Polymerase; D004259:DNA-Directed DNA Polymerase