In-vitro synthesis of anti-acetylcholine-receptor antibody by thymic lymphocytes in myasthenia gravis.
Cultures of thymic tissue or thymic lymphocytes from nine patients undergoing thymectomy for myasthenia gravis were examined for evidence of anti-acetylcholine-receptor-antibody synthesis. One of four thymic tissues and three of five thymic lymphocyte preparations synthesised this antibody.
D000109:Acetylcholine / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D009157:Myasthenia Gravis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
D001323:Autoantibodies; D000109:Acetylcholine