The identification of individuals at high risk for large bowel cancer and the application of preventive measures in their management: chromosome studies in Gardner syndrome and familial polyposis.
The significance of chromosomal markers in linkage and assignment has been pointed out. The usefulness of linkage in disease prevention is discussed with the limitations of this approach.
D002875:Chromosomes / Q000648:ultrastructure; D002877:Chromosomes, Human; D003110:Colonic Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D011110:Polymorphism, Genetic; D011127:Polyps / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics*; D013194:Staining and Labeling