Delayed hypersensitivity reactions of cancer patients to antigens on lymphoid cell lines.
Four-hundred and fifty nine cancer patients were skin tested with extracts from five lymphoid cell lines. More than 50% of patients with lymphoma had positive skin tests with the extracts prepared from the cell line derived from Burkitt's lymphoma (BL) and more than 50% of nasopharyngeal carcinoma (NPC) patients reacted to the NPC-derived cell line extracts. Although the significant association between patient diagnosis and orgin of cell lines suggested that tumor-associated antigens were responsible for the pattern of delayed hypersensitivity, problems in standardization of antigen potency and non-specificity need to be resolved before this in vivo assay achieves its full potential.
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D002051:Burkitt Lymphoma / Q000276:immunology; D002460:Cell Line; D002464:Cell Migration Inhibition; D000939:Epitopes; D006801:Humans; D006968:Hypersensitivity, Delayed; D007428:Intradermal Tests; D007945:Leukemia, Lymphoid / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000939:Epitopes