[Changes of platelet function, coagulation and fibrinolysis during induction of labour at term by prostaglandin F2alpha and oxytocin (author's transl)].
Platelet function (induced and spontaneous aggregability according to Born and Breddin respectively) and some parameters of coagulation and fibrinolysis have been investiagted during induction of term labour by PgF2alpha i.v. (n = 9) and oxytocin i.v. (n = 9). During infusion of PgF2alpha there was a slight decrease of platelet aggregation with both methods. Desaggregation in the Born-test was increased. On the contrary there was no change of platelet function except a small increase of the speed of aggregation if one applicates oxytocin. The parameters of the plasmatic coagulation system remained almost unchanged in both groups and hint only at a slight increase of the fibrinolytic activity in the oxytocin group. The clinical importance of the results is discussed.
D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D007751:Labor, Induced; D010121:Oxytocin / Q000627:therapeutic use; D010958:Plasminogen / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects*; D011247:Pregnancy; D011460:Prostaglandins F / Q000627:therapeutic use*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D011460:Prostaglandins F; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010121:Oxytocin; D010958:Plasminogen
Veränderungen von Thrombozytenfunktion, Gerinnung und Fibrinolyse bei Geburtseinleitung mit PgF2alpha und oxytocin.