Effects of feeding lindane to dogs for periods of up to 2 years.
Lindane was administered to male and female Beagle dogs at dietary levels of 25, 50 and 100 ppm for 104 weeks, and of 200 ppm for 32 weeks. One death at 25 ppm and one at 200 ppm were not considered to be related to the test compound. At 100 and 200 ppm, SAP levels were raised and the livers were dark, friable and slightly enlarged but without any detected histopathological change. HVSA changes, possibly indicative of non-specific neuronal irritation, were recorded in the EEG tracings at 200 but not at 100 ppm. There were no other indications of an adverse effect of lindane. The negative findings at 50 ppm are consistent with a 'no-effect level' for this species of 1.25 mg/kg body weight, comparable with for the rat, and with proposed human ADI of 0.0125 mg/kg body weight.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D001556:Hexachlorocyclohexane / Q000032:analysis / Q000633:toxicity*; D008099:Liver / Q000032:analysis / Q000187:drug effects; D008297:Male; D013997:Time Factors
D001556:Hexachlorocyclohexane