Effect of meseclazone and other non-steroidal anti-inflammatory drugs on isolated tracheal chain tone.
Meseclazone, 5-CSA and several representative NSAIDs caused concentration-dependent relaxation of the tracheal ring preparation and are listed in order of descending potency: isoproterenol greater than naproxen greater than ibuprofen greater than diflunisal greater than tolmetin approximately equal to fenoprofen approximately equal to indomethacin greater than phenylbutazone greater than meseclazone greater than 5-CSA greater than aspirin. This relaxation may be related to inhibition of prostaglandin synthetase, but relative potencies of NSAIDs in this test do not necessarily correspond to their potency in inhibiting PG synthethase in other tissue. Thus other factors may play a role.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D010078:Oxazines / Q000031:analogs & derivatives / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D010078:Oxazines