[Relative sensitivity of various cell cultures to the thermostable exotoxin of B. thuringiensis].
The "thermostable" B. thuringiensis exotoxin is active on cell cultures of Mammals "in vitro", except on the KB strain from a human tumor. The primary cultures are the most sensitive: first, with monkey kidney cells, the growth is inhibited by 0.1 mg of toxin per ml; next, the young rabbit kidney cells react to 0.25 mg of toxin per ml. The established lines of cells come last: human diploid cells (Lyon 4) and heteroploid cells (BHK21C13), with the same active dose of 1 mg of toxin per ml. No protection is obtained by adding ATP to monkey kidney cells at the same time as the exotoxin.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001413:Bacillus thuringiensis; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects* / Q000254:growth & development; D005098:Exotoxins / Q000494:pharmacology*; D000882:Haplorhini; D006801:Humans; D007668:Kidney; D011817:Rabbits
D005098:Exotoxins; D000255:Adenosine Triphosphate
Sensibilité relative de diverses cultures cellulaires vis-à-vis de l'exotoxine thermostable de B. thuringiensis.