Immunological nature of genetic resistance of mice to herpes simplex virus type 1 infection.
Treatment of mice genetically resistant to HSV-1 with agents which impair T-cell or macrophage function markedly diminished resistance. Bone marrow transplantation of genetically susceptible mice with marrow from resistant F1 mice produced chimeras resistant to HSV-1. Resistance thus appears to be immunological in nature. Striking similarities were found between resistance to HSV-1 and allogeneic resistance.
D000818:Animals; D016026:Bone Marrow Transplantation; D005802:Genes, MHC Class II; D006084:Graft Rejection; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology*; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous