title: Preliminary evaluation of the histotoxicity and radiopacity of lead-containing elastic impression materials.
abstract: Severe reactions can be caused when elastic impression materials are trapped beneath soft tissues. To develop a rank order of severity of responses, a series of these materials was injected beneath the oral mucosa of a baboon. Alginate and polysulfide rubbers containing lead peroxide produced severe reactions; hydrocolloid, polysulfide without lead, silicone, and polyether produced more mild reactions. The more toxic materials proved to be more radiopaque than the others. Tests for foreign body toxicity should be made a part of future specifications for these materials, and the use of toxic ingredients should be reduced as much as possible. These materials should be made opaque to X rays and of a different color than those of soft or hard tissues.
mesh_terms: D000038:Abscess / Q000139:chemically induced; D000464:Alginates / Q000494:pharmacology; D000818:Animals; D003102:Colloids / Q000494:pharmacology; D003287:Contrast Media; D003300:Copper; D003760:Dental Impression Materials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced; D004987:Ethers / Q000494:pharmacology; D000882:Haplorhini; D007854:Lead / Q000494:pharmacology*; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects*; D010215:Papio; D011108:Polymers; D012826:Silicone Elastomers / Q000494:pharmacology; D013440:Sulfides / Q000494:pharmacology; D013492:Suppuration / Q000139:chemically induced
chemical_list: D000464:Alginates; D003102:Colloids; D003287:Contrast Media; D003760:Dental Impression Materials; D004987:Ethers; D011108:Polymers; D012826:Silicone Elastomers; D013440:Sulfides; D007854:Lead; D003300:Copper