Epidermal growth factor stimulates proliferation of rat hepatoma cells producing alpha-fetoprotein.
Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. However, the increase in cell number was not accompanied by a proportional increase in the levels of alpha-fetoprotein of the culture media. The effects of EGF on the cell proliferation were antagonized by N6,O2'-dibutyryl cAMP.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D007328:Insulin; D010455:Peptides; D000509:alpha-Fetoproteins; D004815:Epidermal Growth Factor; D003994:Bucladesine; D013936:Thymidine