Circulating carcinoembryonic antigen immune complexes in sera of patients with carcinomata of the gastrointestinal tract.
The sera of patients with histologically proven carcinomata of the gastrointestinal tract were fractionated by gel filtration and the fractions assayed for the presence of free carcinoembryonic antigen (CEA) binding immunoglobulins and CEA immune complexes by radioimmuno-double-diffusion, using 125I-CEA as a marker. In eleven out of thirteen cases with disease recurrence, the presence of CEA-IgM complexes was observed, and in three out of thirteen cases the presence of CEA-IgG complexes, could be demonstrated. Free CEA-binding immunoglobulins could not be detected.
D000230:Adenocarcinoma / Q000276:immunology*; D000936:Antigen-Antibody Complex; D002272:Carcinoembryonic Antigen / Q000032:analysis* / Q000276:immunology; D002850:Chromatography, Gel; D005770:Gastrointestinal Neoplasms / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D007136:Immunoglobulins / Q000032:analysis / Q000276:immunology; D008970:Molecular Weight
D000936:Antigen-Antibody Complex; D002272:Carcinoembryonic Antigen; D007136:Immunoglobulins