title: Design and evaluation of leukaemia trials.
abstract: A satisfactory clinical trial in acute leukaemia has always required a substantial investment in terms of both time and resources. Today, the therapeutic success in the disease is increasing further the difficulty in carrying such trials through to completion. Unless careful thought is given to all aspects of these trials prior to their initiation, there is a very real risk that discoveries of further improvements in treatment through clinical trials may be greatly delayed.
mesh_terms: D000208:Acute Disease; D000328:Adult; D002490:Central Nervous System / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D007938:Leukemia / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D007945:Leukemia, Lymphoid / Q000628:therapy; D008134:Long-Term Care; D012075:Remission, Spontaneous; D013997:Time Factors; D014481:United States