[Effect of reserpine on the formation of 9,10-dimethyl-1,2-benzanthracene induced tumors in pinealectomized and thymectomized rats].
After reserpine treatment the incidence of dimethylbenzanthracene-induced tumors was found to be significantly higher in pinealectomized rats than in intact or thymectomized ones. A very high rate of DMBA-leukemia was observed in immune-deficient pinealectomized rats after reserpine administration. It is therefore suggested that the neuroendocrine disturbances due to removal of the pineal gland in the newborn animals, are latent and become evident after reserpine administration as reflected in an increased tumor incidence.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D007942:Leukemia, Experimental; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010870:Pineal Gland / Q000601:surgery; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013934:Thymectomy
D015127:9,10-Dimethyl-1,2-benzanthracene; D012110:Reserpine
Auswirkung von Reserpin auf das Auftreten von 9,10-Dimethyl-1,2-Benzanthrazen-induzierten Tumoren bei pinealketomierten und thymektomierten Ratten.