Ovarian activity, and total gonadotrophin and gonadotrophin releasing hormone levels in response to some synthetic non-steroidal ovulating agents in the catfish, Heteropneustes fossilis (Bloch).
Effects of clomiphene citrate, cyclofenil and prostaglandins (PGE1 and PGF2 alpha) on ovarian 32P uptake, on gonadotrophin levels in the pituitary gland and blood serum and on a gonadotrophin releasing hormone-like (GnRH-like) substance in the hypothalamus were investigated in Heteropneustes fossilis. These drugs were very effective in increasing the serum level of gonadotrophin with a subsequent increase in ovarian 32P uptake in sham-hypophysectomized recipients. All the drugs except cyclofenil failed to stimulate 32P incorporation by the ovary in hypophysectomized fish. Clomiphene citrate and cyclofenil also induced a significant increase in the GnRH-like factor in the hypothalamus of H. fossilis. Such a response was not obtained in fish treated with PGE1 and PGF2 alpha. It seems likely that the action of clomiphene is routed through the hypothalamo-pituitary-ovarian axis and that of prostaglandins directly through the pituitary-ovarian axis. The action of cyclofenil is bimodal; one effect like that of clomiphene and the other direct upon the ovary probably by increasing its sensitivity to the available gonadotrophin.
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology; D003506:Cyclofenil / Q000494:pharmacology; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D005399:Fishes / Q000378:metabolism*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D007016:Hypophysectomy; D007031:Hypothalamus / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology; D014020:Tissue Extracts / Q000494:pharmacology
D005300:Fertility Agents, Female; D006065:Gonadotropins, Pituitary; D010906:Pituitary Hormone-Releasing Hormones; D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D014020:Tissue Extracts; D002996:Clomiphene; D010758:Phosphorus; D003506:Cyclofenil