title: Confirmation by radial immunodiffusion of depression of the fourth component of complement in guinea pigs fed aflatoxin or rubratoxin.
abstract: Guinea pigs were fed either aflatoxin or rubratoxin in concentrations known to reduce serum complement activity. Depression of complement activity was accompanied by a decrease in C4. The measurement of C4 by radial immunodiffusion indicated it to be a useful and simple procedure for testing the effect of hepatotoxic mycotoxins on a component of the complement system of guinea pigs.
mesh_terms: D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D003181:Complement C4 / Q000037:antagonists & inhibitors*; D003169:Complement Inactivator Proteins; D006168:Guinea Pigs; D005779:Immunodiffusion; D009183:Mycotoxins / Q000494:pharmacology*
chemical_list: D000348:Aflatoxins; D003181:Complement C4; D003169:Complement Inactivator Proteins; D009183:Mycotoxins