A role for clonal dominance in the maintenance of allotype suppression?
The establishment of immunological memory during the early and complete phase of allotype suppression in the young rabbit has been shown to lead to the preferential production of antibodies with the nonsuppressed allotypic specificity in response to recall injections given after spontaneous or induced release from suppression. It is suggested that this manifestation of clonal dominance, applied to stimulation by environmental antigens, may contribute to the long lasting persistence of allotype imbalance in allotype suppressed rabbits.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002999:Clone Cells; D005260:Female; D005293:Ferritins / Q000276:immunology; D006433:Hemocyanins / Q000276:immunology; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis*; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D011817:Rabbits; D013604:T-Phages / Q000276:immunology
D000914:Antibodies, Viral; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains; D010047:Ovalbumin; D005293:Ferritins; D006433:Hemocyanins