Developmental pharmacology and the Ah locus: regulatory and temporal genes affecting teratogenesis.
The "Ah cluster" is a group of regulatory, temporal, and structural genes associated with the inducibility of numerous monooxygenase activities by polycyclic aromatic compounds such as 3-methylcholanthrene. Age- and tissue-specific differences in temporal control of these enzymes are shown to exist. These differences could be important in the age- and tissue-specific differences in one's susceptibility to cancer, drug toxicity, and birth defects. Allelic differences at the Ah locus are shown in the mouse to be associated with benzo[a]-pyrene-produced in utero toxicity: increased stillborns, resorptions, and dysmorphogenesis, plus decreased fetal weight.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000014:Abnormalities, Drug-Induced / Q000235:genetics*; D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis; D001580:Benzopyrenes / Q000494:pharmacology; D004790:Enzyme Induction; D005260:Female; D005333:Fetus / Q000201:enzymology; D005796:Genes; D005809:Genes, Regulator; D005838:Genotype; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011817:Rabbits; D013723:Teratogens
D001580:Benzopyrenes; D013723:Teratogens; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases