Metabolism of sulpiride in man and rhesus monkeys.
The metabolism of 14C-carbonyl-sulpiride (form A) and of 14C-3, 4 pyrrolidine-sulpiride (form B) was studied in the rhesus monkey and man. In the monkey, the metabolites in both the urine and the bile were the same with form A and form B: 60-80% sulpiride, 10-30% 5-oxopyrrolidine sulpiride and 3-8% an unidentified metabolite (ME-X). In four human volunteers given a single oral dose of either 108 mg form A or 100 mg form B, more than 95% of the 14C recovered in the urine and feces was unchanged sulpiride. Sulpiride levels in plasma reached maximum in 3 hr and ranged from 232 to 403 ng/ml. The plasma t1/2 was 8.3 hr. Pharmacokinetic analyses indicated little or no biliary excretion of sulpiride in man.
D000328:Adult; D000818:Animals; D001646:Bile / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000032:analysis; D005260:Female; D000882:Haplorhini; D006801:Humans; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D013058:Mass Spectrometry; D013469:Sulpiride / Q000378:metabolism* / Q000652:urine
D013469:Sulpiride