[WR, a new strain of mice, highly sensitive to the cytogenetic effect of thiotepa].
Mice of the WR strain (genotype -aa, +WY) were selected for the appearance of black spots with normal pigmentation, presumably due to genetic recombination in the W gene region. The frequency of heterozigotes +WY with black spots was 25% in the 11th generation. The cytogenetic effect of thioTEPA (dose 5 mg/kg) was investigated in bone marrow cells of C57BL/10 NZW, 101/H and 129/Re mice. Mice of the WR strain were most sensitive to thioTEPA. It is suggested that the WR mice may be used as a sensitive object for the genetical screening of chemical compounds.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D003433:Crosses, Genetic; D005260:Female; D006579:Heterozygote; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains / Q000235:genetics*; D009030:Mosaicism / Q000187:drug effects; D009154:Mutation; D013852:Thiotepa / Q000494:pharmacology*
D013852:Thiotepa
Novaia liniia mysheĭ WR--vysokochuvstvitel'naia k tsitogeneticheskomu éffektu tiotéf.