Synthesis of high affinity antibodies in irradiated rabbits grafted with allogeneic cells from hyperimmune donors.
Irradiated rabbits grafted with allogeneic lymph node, spleen and bone marrow cells from a donor rabbit hyperimmunized against TMV synthesize high affinity antibodies, displaying mainly recipient allotypic specificities, after antigen boosting. By contrast, recipient rabbits from non-immune donors synthesize antibodies of lower affinity. It is suggested that the differentiation of new emerging host B cells is specifically influenced by the presence of donor-memory cells.
D000042:Absorption; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000915:Antibody Affinity; D007106:Immune Sera; D007116:Immunization, Passive; D005779:Immunodiffusion; D007126:Immunoglobulin Allotypes; D017710:Lymphocyte Transfusion; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D014027:Tobacco Mosaic Virus / Q000276:immunology; D014184:Transplantation, Homologous; D014965:X-Rays
D000914:Antibodies, Viral; D007106:Immune Sera; D007126:Immunoglobulin Allotypes