title: Fe(III)-EDTA complex as iron fortification. Further studies.
abstract: The data presented confirm the advantages of Fe(III)-EDTA as a salt for iron fortification. This iron compound exchanges completely with intrinsic wheat iron in the lumen of the gut. The iron absorption data from this salt tested with six different food vehicles compared with the absorption of ferrous sulfate administered with the same vehicles indicate that while the mean absorption from ferrous sulfate varies from 2 to 30% according to the food vehicle mixed with the salt, the absorption from Fe(III)-EDTA remains practically the same. Apparently, the iron absorption from Fe(III)-EDTA complex is slightly or not affected by the presence of vegetable foods or milk. All these data suggest that only a small amount of iron from this salt, about 10 mg/day, would be necessary to prevent iron deficiency anemia even in those populations relying for their subsistence on vegetable food only.
mesh_terms: D000042:Absorption; D000747:Anemia, Hypochromic / Q000517:prevention & control; D004040:Dietary Carbohydrates; D004492:Edetic Acid; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000378:metabolism; D005527:Food, Fortified; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007502:Iron Chelating Agents / Q000378:metabolism*; D008297:Male; D013329:Structure-Activity Relationship; D013431:Sulfates; D014168:Transferrin / Q000378:metabolism; D014908:Triticum
chemical_list: D004040:Dietary Carbohydrates; D005290:Ferric Compounds; D005296:Ferrous Compounds; D006454:Hemoglobins; D007502:Iron Chelating Agents; D013431:Sulfates; D014168:Transferrin; D005293:Ferritins; D004492:Edetic Acid; C019179:Fe(III)-EDTA