Ethanol metabolism in Drosophila melanogaster.
A quantitative study of the transformation of ethanol into acetaldehyde shows that, in Drosophila melanogaster, the mitochondrial ethanol oxidizing system is not very active but that the part played by catalase appears more important than expected. For a strain without alcoholdehydrogenase, ethanol is highly toxic. The presence of acetaldehyde in the culture medium is toxic for all the strains studied. But, since even a strain without any aldehydeoxidase lives normally, the metabolic production of acetaldehyde does not seem dangerous.
D000079:Acetaldehyde / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D002374:Catalase / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity; D013045:Species Specificity; D013997:Time Factors
D000431:Ethanol; D000429:Alcohol Oxidoreductases; D002374:Catalase; D000445:Aldehyde Oxidoreductases; D000079:Acetaldehyde