Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.
UDP-glucuronyltransferase activities towards 2-aminophenol and bilirubin were studied in a total of 70 human subjects, including premature and full-term newborn babies, infants, children and adults. These two activities have been reported in rat to develop latefoetally and neonatally respectively, but in man they both develop neonatally. There is a linear relationship between the logarithm of each liver transferase activity and the logarithm of the number of days after birth during the first 3 months of life, after which each activity remains constant.
D000328:Adult; D000627:Aminophenols / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D002648:Child; D003414:Crigler-Najjar Syndrome / Q000201:enzymology; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000201:enzymology* / Q000254:growth & development
D000627:Aminophenols; D014453:Glucuronosyltransferase; D001663:Bilirubin