Photic and pentylenetetrazol-induced seizure susceptibility in Macaca mulatta.
Ninety-five out of 100 male Macaca mulatta of varying ages from a restricted habitat in N. India showed no abnormal seizure susceptibility or EEG response to photic stimulation and no electro-clinical features of epilepsy after pentylenetetrazol, 40 mg/kg sc.c. Autopsy studies on the remaining five monkeys with increased seizure proneness revealed depressed skull fractures with cortical trauma in four and a neoplasm in one. Presumably, these factors were responsible for the lowered seizure susceptibility to photic stimulation and pentylenetetrazol activation.
D000818:Animals; D001254:Astrocytoma / Q000150:complications / Q000662:veterinary; D001932:Brain Neoplasms / Q000150:complications / Q000662:veterinary; D006259:Craniocerebral Trauma / Q000150:complications / Q000662:veterinary; D004569:Electroencephalography / Q000662:veterinary; D000882:Haplorhini; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000209:etiology* / Q000503:physiopathology; D010433:Pentylenetetrazole; D010775:Photic Stimulation; D012640:Seizures / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*
D010433:Pentylenetetrazole