Clinical trials on chemical radiosensitization of malignant melanoma of the choroid.
The experimental investigations carried out in model systems and on plant, animal or human tissues have demonstrated that it is possible to increase significantly the radiosensitivity of pigmented cells, including hamster melanoma. On the basis of these data, a clinical pilot study was undertaken in order to establish whether a similar methodical approach will prove effective if applied to the radiotherapy of malignant melanoma of the choroid in patients treated with 60Co gamma-rays according to Stallard's technique. Cuprenil and Chelaton Polfa were used as radiosensitizers. The results of therapy differed distinctly in the two groups of patients (receiving or not receiving radiosensitizing drugs), the rate of tumour regression being much higher in those with a parallel pharmacological treatment.
D000328:Adult; D000368:Aged; D002830:Choroid Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use*; D010865:Pilot Projects; D011838:Radiation-Sensitizing Agents
D011838:Radiation-Sensitizing Agents; D004492:Edetic Acid; D010396:Penicillamine