[Action of feeding lindane or/and zineb on aflatoxin B1-induced toxic effects in rat and mouse liver (author's transl)].
The action of the ingestion of balanced diets containing pesticides [lindane (125 ppm) or/and zineb (5200 ppm)] on aflatoxin B1-induced toxic effects (inhibition of RNA and protein syntheses in liver) has been determined in two animal species. In the rat, the ingestion of these diets for 4 weeks before aflatoxin B1 treatment (0,7 mg/kg for 3 h), strongly decreased the toxic effects on both transcription and translation. By contrast, in the mouse, the above-mentioned diets did not modify the extent of the inhibition produced by aflatoxin B1 (60 mg/kg for 3 hr) on RNA and protein syntheses. These results were discussed.
D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008297:Male; D051379:Mice; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013045:Species Specificity; D013859:Thiocarbamates / Q000494:pharmacology*; D015038:Zineb / Q000494:pharmacology*
D000348:Aflatoxins; D013859:Thiocarbamates; D001556:Hexachlorocyclohexane; D012313:RNA; D015038:Zineb
Influence de l'ingestion de zinèbe ou/et de lindane sur les effets toxiques de l'aflatoxine B1 chez le rat et la souris.