Spinal cord injury: effect of thyrocalcitonin on periarticular bone formation in three subjects.
Sodium fluoride 18F scintimetry was performed before and after 1 month of salmon thyrocalcitonin treatment of 3 spinal cord injured patients with periarticular ossification of the hips and knees. Thyrocalcitonin therapy caused a marked diminution of 18F uptake in 1 patient with long-standing periarticular bone of both hips. Clinically, the range of motion in this subject increased by 25 degrees and there was a marked decrease in pain locally. The results were, however, not duplicated in the 2 patients with periarticular bone formation of short duration.
D000328:Adult; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D005461:Fluorine; D006801:Humans; D007596:Joints; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000188:drug therapy; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013119:Spinal Cord Injuries / Q000503:physiopathology*
D011868:Radioisotopes; D005461:Fluorine; D002116:Calcitonin; D002118:Calcium