Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.
Fifty adult female rats were used to study the effect of 1-alpha-hydroxyvitamin D3 (1alpha-OH-D3) on bone after oophorectomy. The experimental period was 6 months. At the end of the experiment the femurs and the tibias were investigated for bone mass and composition. Significant signs of osteopenia occurred as a result of oophorectomy. The treatment with 1alpha-OH-D3 induced only minor changes in blood chemistry but increased bone mass significantly. The findings support the view that 1alpha-OH-D3 may be a valuable tool in the treatment of osteoporosis resulting from ovarian insufficiency.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002369:Castration; D005260:Female; D005269:Femur; D006887:Hydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D010024:Osteoporosis / Q000188:drug therapy*; D051381:Rats; D013977:Tibia
D006887:Hydroxycholecalciferols