Familial occurrence of monoclonal gammapathies.
The purpose of this work was to evaluate the genetic propensity importance in the monoclonal gammapathies occurrence. Systematic serum-electrophoreses were performed on 172 relatives of 37 reported patients and on 10,784 controls over 30. The 4 families including one or more "paraproteinemia" other than the proband's were investigated. Experimental, epidemiologic, immunologic and genetic arguments are discussed.
D001327:Autoimmune Diseases / Q000235:genetics; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology; D010266:Paraproteins / Q000032:analysis; D010375:Pedigree; D012217:Rheumatoid Factor / Q000032:analysis; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics
D007136:Immunoglobulins; D010266:Paraproteins; D012217:Rheumatoid Factor