Prophylactic treatment of Rocky Mountain spotted fever.
Prophylactic treatment of Rocky Mountain spotted fever with a single dose of oxytetracycline was investigated in guinea pigs. Disease was prevented when treatment was administered shortly before expected onset. Relapses occurred when treatment preceded expected onset by 48 h or more.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D008213:Lymphocyte Activation; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage*; D012008:Recurrence; D012284:Rickettsia rickettsii / Q000276:immunology; D012373:Rocky Mountain Spotted Fever / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors
D000907:Antibodies, Bacterial; D010118:Oxytetracycline