Sulphur-containing metabolites of beta-bromostyrene formed by the marmoset, rabbit and rat.
1. The administration of beta-bromostyrene to the rat results in a fall in the level of hepatic glutathione. 2. Marmosets, rabbits and rats dosed with beta-bromostyrene excrete two mercapturic acids. One of these, N-acetyl-S-(2-hydroxy-2-phenyl-1-bromoethyl)-cysteine is readily converted into N-acetyl-S-(1-phenyl-2-bromo-2-ethenyl)-cysteine, the structure of which was established by mass spectrometry. 3. Mass spectrometric evidence suggests that the second mercapturic acid is N-acetyl-S-(1-hydroxy-2-phenylethyl)cysteine. 4. Mandelic acid was detected as a metabolite in all three species.
D000818:Animals; D002143:Callitrichinae; D003545:Cysteine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D005421:Flavoring Agents / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D000882:Haplorhini; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013343:Styrenes / Q000378:metabolism*; D013997:Time Factors
D005421:Flavoring Agents; D013343:Styrenes; D005978:Glutathione; D003545:Cysteine