Presence of glucuronyltransferase activity in human lymphocytes.
Human lymphocytes contain glucuronyltransferase activity. This enzyme requires a high concentration of uridine diphosphoglucuronic acid and can be measured with testosterone as a substrate. This finding is of interest because glucuronidation is a deactivating process for many pharmacologically active compounds that are substrates of glucuronyltransferase.
D001402:B-Lymphocytes / Q000201:enzymology; D002460:Cell Line; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000201:enzymology*; D013739:Testosterone / Q000378:metabolism; D013997:Time Factors
D005965:Glucuronates; D013739:Testosterone; D014453:Glucuronosyltransferase