24-hour extracorporeal membrane oxygenation in the hypoxic dog: hemodynamics and pulmonary gas exchange.
Hemodynamic and pulmonary gas exchange values were investigated during 24-hour extracorporeal membrane oxygenation performed on 7 anesthetized dogs subjected to alveolar hypoxia. The chief effects of extracorporeal membrane oxygenation were demonstrated. The duration of the extracorporeal membrane oxygenation was associated with a progressive decline in the systemic arterial pressure and heart rate and a progressive increase in the pulmonary blood flow rate. Left-ventricular stroke work remained constant. The sum of the pulmonary and extracorporeal oxygen uptakes showed no change in spite of large variations in pulmonary flow rate.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D004285:Dogs; D005112:Extracorporeal Circulation; D006339:Heart Rate; D006439:Hemodynamics; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D011652:Pulmonary Circulation; D012039:Regional Blood Flow; D014655:Vascular Resistance
D002245:Carbon Dioxide; D010100:Oxygen