MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats.
Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats. The effects of serotonin (5-HT) and 5-methoxytryptamine (5-MT) are greatly potentiated by these substances. Brain levels of LSD are not affected by MAO inhibition whereas levels of 5-HT and 5-MT are significantly elevated. It is postulated that the decreased behavioral response to LSD is the result of 'MAO inhibitor-induced' changes whereas the increased response of 5-HT and 5-MT results from increased brain levels of these compounds.
D008735:5-Methoxytryptamine / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001923:Brain Chemistry; D003010:Clorgyline / Q000494:pharmacology; D007276:Injections, Intraventricular; D007490:Iproniazid / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis / Q000494:pharmacology*; D014363:Tryptamines / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines; D012642:Selegiline; D012701:Serotonin; D008735:5-Methoxytryptamine; D008238:Lysergic Acid Diethylamide; D007490:Iproniazid; D003010:Clorgyline