Inactivation of slow reacting substance of anaphylaxis (SRS-A) by lipoxidase.
Lipoxidase (E.C.1.13.1.13) inactivates rat SRS-A. The inactivation is time, temperature, and concentration-dependent. Linoleic acid and eicosatetraynoic acid inhibit the enzymatic deactivation of the mediator. It is concluded that SRS-A is a genuine substrate for lipoxidase and contains a cis, cis-1, 4-pentadiene structure. It is suggested that lipoxidase could play a major role in tissue removal of the mediator during hypersensitivity reactions.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D008041:Linoleic Acids / Q000494:pharmacology; D008084:Lipoxygenase / Q000494:pharmacology*; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013696:Temperature; D013997:Time Factors
D001095:Arachidonic Acids; D008041:Linoleic Acids; D013189:SRS-A; D008084:Lipoxygenase