Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity.
Both during the primary (localized) inflammation and the development of the secondary (generalized) inflammation in adjuvant-treated rats, the plasma level of functional alpha-macroglobulins increases while proteases (measured as peptide hydrolases) sharply decrease. The decreased peptide hydrolase levels during episodes when protease 'spillage' into the bloodstream is elevated, suggests a more rapid clearance of alpha-macroglobulin-protease complexes associated with inflammation.
D000276:Adjuvants, Immunologic; D000818:Animals; D001799:Blood Sedimentation; D007249:Inflammation / Q000097:blood* / Q000201:enzymology / Q000209:etiology; D008297:Male; D009174:Mycoplasma / Q000276:immunology; D010447:Peptide Hydrolases / Q000097:blood*; D011480:Protease Inhibitors / Q000097:blood*; D051381:Rats; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000276:Adjuvants, Immunologic; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010447:Peptide Hydrolases