A species comparison of 2,4-dinitrotoluene metabolism in vitro.
Postmitochondrial supernatants prepared from livers of mice, rats, rabbits, dogs, and monkeys metabolized 2,4-dinitrotulene. The pattern of metabolites was characterized in both sexes of the species examined. In addition, the pattern of metabolites was altered by varying incubation conditions and pretreating male rats with phenobarbital or SKF 525-A.
D000818:Animals; D002250:Carbon Radioisotopes; D004136:Dinitrobenzenes; D004285:Dogs; D005260:Female; D000882:Haplorhini; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008253:Macaca mulatta; D008297:Male; D009574:Nitro Compounds / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D011817:Rabbits; D012737:Sex Factors; D013045:Species Specificity; D014050:Toluene / Q000031:analogs & derivatives* / Q000378:metabolism
D002250:Carbon Radioisotopes; D004136:Dinitrobenzenes; D009574:Nitro Compounds; D014050:Toluene; C016403:2,4-dinitrotoluene; D011335:Proadifen; D010634:Phenobarbital