Short term effects of Clophen A 50 and of dichlorobiphenyl in rats.
In short term experiments, rats were treated with single oral doses of the polychlorinated biphenyls (PCB's), Clophen A 50 (high chlorinated compound) and dichlorobiphenyl (low chlorinated compound). Clophen A 50 treatment resulted in a marked increase in liver weight and in the activities of GPT, GOT and G1DH in rat serum at 1000 mg/kg similar effects were observed, but to a lesser degree. The levels of the serum lipids, cholesterol and triglycerides were significantly elevated at both dose levels and they remained elevated up to seven days. In contrast, one single oral dose of 1000 mg of dichlorobiphenyl per kg did not cause significant changes in the above mentioned parameters. Histological examination of the liver showed irregularly disseminated droplets of fat in both experiments. These results indicate that Clophen A 50 causes liver damage and alters the lipid metabolism of rats, whereas the low chlorinated dichlorobiphenyl does not exert such effects.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol; D011078:Polychlorinated Biphenyls; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin