[Use of blockers and stimulators of prolactin secretion in the syndrome of persistent lactorrhea--amenorrhea].
The results of use of rifathyroin (the Soviet preparation thyroliberin), a stimulant of prolactin secretion, and of L-DOPA and cholstylbegit, blockers of prolactin secretion, in patients with various forms of the persisting lactorrhea-amenorrhea syndrome are presented in this work. Reaction of rifathyroin proved to be disturbed in these patients, i.e. decreased in adenomas and hypothalamic disturbances and exceedingly increased in combination of primary hypothyroidism and lactorrhea. L-DOPA and chlostylbegit were capable of reducing prolactin level in patients with the persisting lactorrhea-amenorrhea syndrome, this being accompanied by restoration of biphasic menstrual cycle in some of the patients. The use of estrogens led to increase of the serum prolactin level. Problems of diagnostic value of the test with rifathyroin, and of the efficacy of various therapeutic methods applied in lactorrhea-amenorrhea are discussed.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy / Q000503:physiopathology*; D002996:Clomiphene / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005687:Galactorrhea / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007775:Lactation Disorders / Q000503:physiopathology*; D007980:Levodopa / Q000627:therapeutic use; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D013577:Syndrome; D013973:Thyrotropin-Releasing Hormone
D003278:Contraceptives, Oral, Hormonal; D002996:Clomiphene; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin
Primenenie blokatorov i stimuliatorov sekretsii prolaktina pri sindrome persistiruiushcheĭ laktorei--amenorei.