Neuronal ischemic injury: light microscopy, ultrastructure and biochemistry.
A uniform, predictable pattern of cellular abnormalities is seen after complete, irreversible ischemic injury to the central nervous system. This is in contrast to the heterogeneous, multifocal picture which characterizes incomplete ischemia. The range of abnormalities in neuronal soma after an arterial occlusion changes considerably as a function of time and site. There is no single pattern of neuronal alteration that can be ascribed exclusively to ischemia. Red neurons are a relatively late (about 18 h) indicator of ischemia and are seen only in areas where blood supply is marginal. In addition to depletion of high-energy-phosphate reserves, brain ischemia results in characteristic alterations of amino acid concentrations in the ischemic tissue. Glutamate, glutamine, and aspartate either decrease or remain constant while alanine increases. Proportional decreases in the former three amino acids may be explained by simple dilution due to edema. Increases in alanine relative to glutamate and aspartate may be utilized as a biochemical index of perfusion to various brain regions.
D000409:Alanine / Q000032:analysis; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis; D001921:Brain / Q000098:blood supply; D001923:Brain Chemistry; D001926:Brain Death; D002415:Cats; D002470:Cell Survival; D002561:Cerebrovascular Disorders / Q000473:pathology; D004678:Encephalomalacia / Q000473:pathology; D005260:Female; D005971:Glutamates / Q000032:analysis; D005973:Glutamine / Q000032:analysis; D000882:Haplorhini; D006801:Humans; D007511:Ischemia / Q000473:pathology*; D008253:Macaca mulatta; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D013997:Time Factors
D005971:Glutamates; D005973:Glutamine; D001224:Aspartic Acid; D000409:Alanine