Medically refractory unstable angina pectoris. II. Hemodynamic and angiographic effects of intraaortic balloon counterpulsation.
Of 60 patients receiving intraaortic balloon counterpulsation for angina refractory to maximal medical therapy, a subgroup of 10 patients underwent left ventricular angiography both with and without counterpulsation. Severe stenosis of the left anterior descending coronary artery was present in all 10 patients. Counterpulsation resulted in a significant decrease in systolic and end-diastolic left ventricular pressures and no increase in cardiac index. Left ventricular diastolic and systolic volume, ejection fraction and regional contraction patterns, often abnormal, were unchanged. However, mean normalized systolic ejection rate was improved by the addition of counterpulsation. It is concluded that intraaortic balloon counterpulsation has relatively little effect on the left ventricular volume of patients with medically refractory angina pectoris. The symptomatic improvement that takes place seems to occur mainly through the effect of counterpulsation on preload and afterload.
D000284:Administration, Oral; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D000790:Angiocardiography; D001243:Assisted Circulation; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use; D009824:Ointments; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use; D011652:Pulmonary Circulation
D009824:Ointments; D011433:Propranolol; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate