title: Pleiotropic control mutations affecting the sporulation of Bacillus subtilis.
abstract: Mutations affecting quantitatively the production of the sporulation-associated extracellular alkaline protease were isolated and characterized. They fall into at least five genes, three of which, ScoA, B and C, were mapped in the argC-metC region. The pleiotropic effects of these mutations concern several or all of the following: rate and timing of protease production, synthesis of alkaline phosphatase, time-course of spore formation. Electron microscopic evidence indicates delayed switch from one morphological stage to another. The nature of the Sco mutations and the genetic regulation of sporulation are discussed.
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis; D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D002874:Chromosome Mapping; D007700:Kinetics; D008854:Microscopy, Electron; D009024:Morphogenesis; D009154:Mutation; D010447:Peptide Hydrolases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D012098:Reproduction; D013171:Spores, Bacterial / Q000378:metabolism; D000516:alpha-Amylases / Q000096:biosynthesis
chemical_list: D000469:Alkaline Phosphatase; D000516:alpha-Amylases; D010447:Peptide Hydrolases