Serum IgG, IgM and slow alpha-globulin levels in carrageenan-treated rats.
Serum levels of IgM, IgG, slow alpha 1- and slow alpha 2-globulins were measured either by quantitative radial immunodiffusion (IgG) or immunoelectrophoresis (IgM and slow alpha-globulins) during the 3-week period after i.p. injection of 50 mg potassium carrageenan. There was a significant elevation in levels of IgM and slow alpha 1-globulin, maximal on Day 4 and returning to normal by Day 14. Slow alpha 2-globulin was detectable within 24 h, reached a peak at Day 2, and was no longer measurable in most rats by Day 14. Levels of IgG however, were unaffected by carrageenan injection.
D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000378:metabolism*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000096:biosynthesis / Q000378:metabolism*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000511:alpha-Macroglobulins; D002351:Carrageenan