[Antigen-specific T-cell factors in the regulation of the immune response (author's transl)].
We have examined in this brief review several facets of antigen-specific T-cell mediators found independently by different investigators. These factors have many common properties: (1) they are produced as a consequence of antigen stimulation; (2) they are obtained from T-cell populations and not from B cells or macrophages; their synthesis by T cells, however, has not been formally demonstrated; (3) they are antigen-specific and are selectively adsorbed by antigen-Sepharose columns; (4) they lack immunoglobulin constant region determinants of either L or H chain; (5) their estimated molecular weight by gel filtration is between 40,000 and 50,000 daltons; (6) they bear distinct I region controlled determinants; the helper factors are removed by anti-I-A immunoadsorbents; the suppressor factors in different distinct systems bear determinants coded foor by the I-J sub-region.
D000818:Animals; D001665:Binding Sites; D000939:Epitopes; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D007130:Immunoglobulin Idiotypes; D007163:Immunosorbent Techniques; D051379:Mice; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens; D007130:Immunoglobulin Idiotypes
Les mèdiateurs spécifiques impliqués dans la régulation de la réponse immunitaire.