(N-Barbituryl)phenyl- and cyclohexylalkanoic acids and some of their derivatives as potential anti-inflammatory agents.
A series of p-(N-barbituryl)phenyl- and cyclohexylalkanoic acids and their esters were synthesized. The preliminary pharmacological screening using the carrageenin, xylene and cotton tests revealed strong anti-inflammatory activity of several compounds in some of the tests performed, compound (Ij) being active in all the tests.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001241:Aspirin / Q000494:pharmacology; D001463:Barbiturates / Q000138:chemical synthesis* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D007249:Inflammation / Q000503:physiopathology; D008722:Methods; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D001463:Barbiturates; D002264:Carboxylic Acids; D016861:Cyclooxygenase Inhibitors; D010653:Phenylbutazone; D001241:Aspirin