title: Phagocytosis and trypsin-resistant glass adhesion by osteoclasts in culture.
abstract: Osteoclasts were cultured in vitro and tested for the functions normally associated with cells of the mononuclear phagocyte system. They were found to ingest glutaraldehyde-fixed red cells and latex, but not opsonised or complement-coated sheep red cells. Osteoclasts are glass-adherent and resist removal by trypsin. The implications of these findings for the identity of the osteoclast precursor cell and its mechanism of fusion are discussed.
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000378:metabolism; D004912:Erythrocytes; D005347:Fibroblasts / Q000502:physiology; D005976:Glutaral / Q000494:pharmacology; D008264:Macrophages / Q000502:physiology; D009895:Opsonin Proteins; D010010:Osteoclasts / Q000187:drug effects*; D010587:Phagocytosis; D011817:Rabbits; D012756:Sheep
chemical_list: D009895:Opsonin Proteins; D003165:Complement System Proteins; D005976:Glutaral