title: Comparative scanning and transmission electron microscopy of the prostatic gland in different species (mouse, rat, dog, man).
abstract: Man, dog, rat and mouse prostatic glandular cells were compared by light microscopy (LM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). In rodents and dogs, a merocrine secretion exists, and in these species the undulating surface represented a confluence of secretory granules. The prominent secretory blebs observed in dog and human benign prostatic hyperplasia (BPH) corresponded to apocrine secretions. Also variations in the amount of secretory activity were seen. Androgenic hormones were responsible for the differentiation of the prostatic epithelial cells during development. Therefore, an absence of microvilli as well as the appearance of ruffles, microplicae, and bare cells were seen in the prepuberal and castrated rat. In the elderly rat and in human BPH, a pleomorphism of the apical cell surface was evident.
mesh_terms: D000367:Age Factors; D000818:Animals; D002369:Castration; D004285:Dogs / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice / Q000502:physiology*; D008854:Microscopy, Electron / Q000379:methods*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008871:Microvilli / Q000648:ultrastructure; D011467:Prostate / Q000648:ultrastructure*; D011470:Prostatic Hyperplasia / Q000473:pathology; D051381:Rats / Q000502:physiology*; D012741:Sexual Maturation; D013045:Species Specificity