Thyrotropin-releasing hormone and thyroid hormones in amniotic fluid.
Immunoassayable TRH (iTRH) was measured in 50 amniotic fluid specimens with a mean concentration of 207 +/- 26 (SE) pg/ml. This iTRH demonstrates parallelism with the standard curve for synthetic TRH. With increasing gestational age there is an increase in iTRH levels in amniotic fluid with a decrease in 3,3',5'-triiodothyronine levels (rT3), while thyroxine levels (T4) remain unaltered. Preliminary data suggest that iTRH levels in amniotic fluid that are less than 150 pg/ml after 32 weeks of gestation may correlate well with low Apgar scores at birth. There was no correlation of rT3 or T4 amniotic fluid levels with the Apgar scores.
D000653:Amniotic Fluid / Q000032:analysis*; D001034:Apgar Score; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D013963:Thyroid Hormones / Q000032:analysis*; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*
D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone