title: Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin.
abstract: A series of ester and amide analogues of ambruticin (1) was prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans and Streptococcus pyogenes. Structure-activity relationships are described.
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004952:Esters / Q000138:chemical synthesis; D005658:Fungi / Q000187:drug effects; D009231:Myxococcales; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000935:Antifungal Agents; D004952:Esters; D011714:Pyrans; C014964:ambruticin