Effect of n-dipropylacetate and L-glutamine on gamma amino-n-butyric acid levels in brains of rats intoxicated with ethanol.
The concentrations of gamma-amino-n-butyric acid in brains of rats intoxicated with half intraperitoneal LD50 ethanol were determined at various times and found increased at early times (10 min) and decreased later (1 to 3 hours). The concentration tended to be restored to normal values upon administration of n-dipropylacetate (400 mg/kg) or L-glutamine (340 mg/kg). The treatment with both substances showed a positive interaction with an overall positive effect greater than the sum of each.
D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005973:Glutamine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D051381:Rats; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D005973:Glutamine; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid