[Prostatic osteosis. Retrospective study of 110 cases treated with high-dose estrogens].
On the basis of 110 prostatic osteoses that were histologically proven, constantly painful and demonstrated by X-ray, treated by early estrogenotherapy using very high doses, backed up by a high-dose maintenance estrogenotherapy, the authors study the clinical, radiological, histological and biological profile of this metastatic cancer, as well as the response to treatment. The median actuarial survival time of the patients studied is 18.5 months. No statistically significant prognostic correlation was found. Only patients who are clinically estrogen-sensitive, are suffering from bone metastases without a combined visceral conditions, and have a normal initial rate of alcaline phosphates, tend to have a better prognosis (median actuarial survival 31 months versus 18.5 months for the overall population).
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D045166:Estradiol Congeners / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D012189:Retrospective Studies
D045166:Estradiol Congeners
L'ostéose prostatique. Etude rétrospective de 110 observations traitées par les oestrogènes a fortes doses.