Galactorrhea in sarcoidosis: dynamic studies of prolactin, growth and gonadotropic hormone levels.
Five of 300 women with sarcoidosis had galactorrhea. Basal prolactin levels were mildly but significantly elevated when compared to controls and sarcoidosis patients without galactorrhea. Prolactin levels responded to thyrotropin releasing hormone and L-dopa administration, but not chlorpromazine. Luteinizing hormone and follicle-stimulating hormone concentrations responded normally to luteinizing hormone-releasing hormone in all sarcoidosis patients studied, as did growth hormone to insulin hypoglycemia. These results indicate that galactorrhea in sarcoidosis is an uncommon phenomenon, probably due to hypothalamic dysfunction and associated with mildly elevated prolactin levels.
D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000150:complications* / Q000503:physiopathology*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006065:Gonadotropins, Pituitary / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007775:Lactation Disorders / Q000150:complications* / Q000503:physiopathology*; D007980:Levodopa / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D012507:Sarcoidosis / Q000150:complications* / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone
D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D002746:Chlorpromazine