[Enzymatic profile of the exudate leukocytes in diabetes mellitus].
The activity of enzymes regulating the processes providing functional activity of leukocytes was studied in the exudate leukocytes of healthy rabbits and animals with alloxan diabetes. Rabbits with diabetes displayed a reduction of hexokinase, phosphoglucomutase, glucose-6-phosphate dehydrogenase and adenylate kinase activity. The activity of UDPH-pyrophosphorylase, UDPH-glycogentranspherase, 6-phosphogluconate dehydrogenase and glutathion reductase showed no significant changes in the exudate leukocytes in diabetes. A reduction of hexokinase and glucose-6-phosphate dehydrogenase limiting glycolysis and the pentose-phosphate cycle, respectively, providing energy for leukocytes and important in protein metabolism of these cells, is of great significance in the reduction of functional activity of leukocytes in the inflammatory focus in diabetes.
D000263:Adenylate Kinase / Q000378:metabolism; D000496:Alloxan; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates; D005980:Glutathione Reductase / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology*; D010733:Phosphoglucomutase / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D011817:Rabbits; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase / Q000378:metabolism
D005958:Glucosephosphates; D000496:Alloxan; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D006006:Glycogen Synthase; D006593:Hexokinase; D000263:Adenylate Kinase; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase; D010733:Phosphoglucomutase
Enzimaticheskiĭ profil' leĭkotsitov ekssudata pri diabete.