title: Decrease in vital capacity in PCB-exposed workers in a capacitor manufacturing facility.
abstract: Pulmonary function was evaluated in 243 workers exposed to PCB in the manufacture of capacitors. Mean employment was greater than 15 years. Thirty-four of the workers (14%) were found to have a reduced Forced Vital Capacity (FVC less than 80% of Morris' predicted). Of the 34 with reduced FVC, 27 (80%) demonstrated a restrictive pattern of impairment (FEV1/FVC greater than 0.7). Only one of these 27 workers had an abnormal chest roentgenogram (greater than or equal to 1/0 by ILO UC Classification of Radiographs of Pneumoconioses). These findings are of interest in view of recent experimental data indicating the accumulation of PCBs and PCB metabolites in lung tissue (Brandt and Jansson). Restrictive spirometric impairment with no radiographic change is unusual in occupational exposure.
mesh_terms: D000328:Adult; D001991:Bronchitis / Q000139:chemically induced* / Q000503:physiopathology; D005069:Evaluation Studies as Topic; D005128:Eye Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D012907:Smoking; D014797:Vital Capacity / Q000187:drug effects*
chemical_list: D011078:Polychlorinated Biphenyls