title: [Treatment of chronic coronary insufficiency with Irrigor].
abstract: The results of treatment of 103 patients suffering from ischemic heart disease with irrigor for 7--25 days are discussed. The drug was given in a daily dose of 30 to 150 mg in tablets, intramuscularly, and intravenously. Ergometry, study of the values of central hemodynamics and lipid metabolism, and recording of the rheoencephalo-, rheovaso-, and electroencephalogram were conducted before and after the treatment. The efficacy of irrigor was appraised in treatment applied in courses, in a single intravenous infusion, and under conditions of the double blind method. A relatively stable clinical effect was noted on the 9th--12th day. A good effect was produced in 49.3% of patients. The efficacy of irrigor was the highest in patients with grade I and II chronic coronary insufficiency, with no history of circulatory insufficiency or myocardial infarction, and in intramuscular and intravenous administration. Treatment with irrigor improved the indices of central hemodynamics and cerebral and peripheral blood flow. No side effects of the treatment were noted. The study showed irrigor to be an effective agent in the treatment of ischemic heart disease.
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003327:Coronary Disease / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D010069:Oxadiazoles / Q000008:administration & dosage*; D010919:Placebos; D012306:Risk; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D010069:Oxadiazoles; D010919:Placebos; D014665:Vasodilator Agents; D005996:Nitroglycerin; C002787:imolamine
vernacular_title: Lechenie bol'nykh s khronicheskoĭ koronarnoĭ nedostatochnost'iu irrigorom.