Studies on the clastogenic effects of biologic stains and dyes.
We have surveyed the clastogenic potential of 12 different groups of stains and dyes totalling 48 compounds. We observed that 18 compounds induced significant increase in chromosome damage. Most of them were also found to be mutagenic, carcinogenic, or toxic in other reported studies. However, no significant studies were reported on six of them. It is concluded that these agents are potentially harzardous and should be studied further in detail.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004396:Coloring Agents / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D009152:Mutagenicity Tests; D009153:Mutagens; D010053:Ovary; D013194:Staining and Labeling
D004396:Coloring Agents; D009153:Mutagens