A comparison of the effects of 50 MeVd leads to be neutron and cobalt-60 irradiation of the kidneys of rhesus monkeys.
Twenty rhesus monkeys had one kidney irradiated (after undergoing unilateral nephrectomies) with one of four doses: 960 or 1080 rads of 50 MeVd leads to Be neutrons, or 2350 or 2700 rads of 60Co. Whereas animals treated with the lower dose of neutrons or 60Co are alive with relatively normal renal function, those treated with the higher dose of neutrons died of radiation nephritis. Animals treated with the higher dose of 60Co developed radiation nephritis but survived. The physiological and histopathological changes of radiation nephritis secondary to neutron irradiation are not qualitatively different from those reported for radiation nephritis secondary to photon irradiation.
D000818:Animals; D003037:Cobalt Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D000882:Haplorhini; D007668:Kidney / Q000528:radiation effects*; D007678:Kidney Glomerulus / Q000528:radiation effects; D007684:Kidney Tubules / Q000473:pathology / Q000528:radiation effects; D008253:Macaca mulatta; D008297:Male; D009392:Nephrectomy; D009393:Nephritis / Q000209:etiology / Q000473:pathology; D009502:Neutrons; D011832:Radiation Injuries / Q000473:pathology; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012077:Renal Artery / Q000528:radiation effects; D012082:Renal Veins / Q000528:radiation effects
D003037:Cobalt Radioisotopes