[Antibacterial in-vitro activity of pipemidic acid and nalidixic acid (author's transl)].
The in-vitro activity of nalidixic acid and pipemidic acid was investigated in a combined study in 450 freshly isolated bacterial strains using the agar dilution test. Gram-positive cocci were resistant to both substances except for a few pipemidic acid sensitive staphylococci. Both substances had good antibacterial activity in the gram-negative spectrum. However, the MIC values of pipemidic acid were generally clearly lower than those of nalidixic acid. Only pipemidic acid showed activity against Pseudomonas aeruginosa. Thus the in-vitro results showed that pipemidic acid has clear-cut and valuable advantages for the treatment of urinary tract infections when compared with nalidixic acid.
D000900:Anti-Bacterial Agents; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007709:Klebsiella / Q000187:drug effects; D009268:Nalidixic Acid / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D010876:Pipemidic Acid / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D009539:Nicotinic Acids; D009268:Nalidixic Acid; D010876:Pipemidic Acid
Antibakterielle In-vitro-Wirksamkeit von Pipemidsäure und Nalidixinsäure. Vergleichende Untersuchungen.