title: Maternal allotype dominance and allelic exclusion in the B lineage cells of the newborn rabbit.
abstract: Newborn rabbits from parents which differ at the b allotype locus (kappa chain), show a strong maternal allotype dominance, especially in the bone marrow. This concerns not only the membrane but also the cytoplasm, and it cannot be simply due to a passive uptake of maternal immunoglobulins. The spleen precedes the bone marrow for a high level of expression of the paternal allotype. In the thymus, cells which contain cytoplasmic immunoglobulin are found at low frequency, but their absolute number represent a substantial contribution to the B lineage cell pool. A small proportion of such thymus cells do not show allelic exclusion of kappa chain allotypes.
mesh_terms: D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000196:embryology; D005260:Female; D005799:Genes, Dominant; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains; D008221:Lymphoid Tissue / Q000196:embryology; D008297:Male; D011817:Rabbits; D013154:Spleen / Q000196:embryology; D013950:Thymus Gland / Q000196:embryology
chemical_list: D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains