Evaluation of the teratogenicity of anticonvulsants.
Evaluation and comparison of the reports on teratogenicity of drugs are very difficult because many fundamental, clinical and social problems exist in the research of congenital anomalies and detection of human teratogens. Since the etiological significance of anti-convulsants has not been established in humans, the following efforts should be made extensively: 1) systematic collection and detailed analysis of more human cases, 2) study on the role of epilepsy and treatment with multiple drugs, 3) investigation on the mechanism of teratogenesis including comparative pharmacokinetic studies in animals and humans.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D000882:Haplorhini; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D051381:Rats
D000927:Anticonvulsants