Regulation of the rate of beta-galactosidase synthese by the Bgs and Bgt loci in the mouse.
We have developed an assay for the in vivo rate of beta-galactosidase synthesis in mouse tissues to assess the mechanism by which the Bgs and Bgt loci regulate activity levels of this enzyme. Genetically determined differences in liver and kidney beta-galactosidase content reflect equivalent differences in specific rates of enzyme synthesis. We conclude that Bgs and Bgt regulate beta-galactosidase activity by controlling the rate of synthesis of the beta-galactosidase molecule.
D000483:Alleles; D000818:Animals; D005696:Galactosidases / Q000235:genetics*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D009928:Organ Specificity; D013045:Species Specificity; D001616:beta-Galactosidase / Q000096:biosynthesis / Q000235:genetics*
D005696:Galactosidases; D001616:beta-Galactosidase