Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability.
A quantitative ratio measure was developed which permitted comparisons between the reinforcing and anorectic potency of eight phenylethylamine anorectics and cocaine in laboratory baboons. The ordering of these compounds based upon this ratio bears a reasonable correspondence to clinical drug evaluations. The measure may provide information for preclinical evaluation of relative abuse potential of anorectic drugs.
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000494:pharmacology*; D002745:Chlorphentermine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004053:Diethylpropion / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005277:Fenfluramine / Q000494:pharmacology; D000882:Haplorhini; D006801:Humans; D010215:Papio; D010627:Phenethylamines / Q000494:pharmacology; D010633:Phenmetrazine / Q000494:pharmacology; D010645:Phentermine / Q000494:pharmacology; D010665:Phenylpropanolamine / Q000494:pharmacology; D012054:Reinforcement, Psychology; D019966:Substance-Related Disorders / Q000517:prevention & control*
D001067:Appetite Depressants; D010627:Phenethylamines; D005277:Fenfluramine; D010665:Phenylpropanolamine; D010645:Phentermine; D003042:Cocaine; D002745:Chlorphentermine; D004053:Diethylpropion; D003913:Dextroamphetamine; D010633:Phenmetrazine