A comparison of tissue gold levels in guinea-pigs after treatment with myocrisin injected intramuscularly and triethylphosphine gold chloride and myocrisin administered orally.
A comparative study of tissue gold levels produced in guinea-pigs after the oral administration of either triethylphosphine gold chloride or Myocrisin (sodium aurothiomalate) or after the injection of Myocrisin intramuscularly is reported. Gold concentrations were determined 5, 24 and 168 hours after administration in stomach, small intestine, large intestine, kidney, liver and spleen and 5 and 24 hours after administration in skin, adrenals, heart, lung and brain. In gastrointestinal tissues, tissue gold concentrations were highest with triethylphosphine gold chloride. The stomach gold level 5 hours after oral administration of triethylphosphine gold chloride is particularly high and, taken in conjunction with the other gastrointestinal gold levels measured, suggests that a stomach rather than an intestinal absorption mechanism may predominate. A more extensive time-course study on kidney and liver is reported and the possible relationship between tissue concentration and toxicity is discussed.
D000284:Administration, Oral; D000818:Animals; D005260:Female; D006046:Gold / Q000008:administration & dosage / Q000378:metabolism*; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000378:metabolism*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D050607:Organogold Compounds; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000378:metabolism*; D010720:Phosphines; D013997:Time Factors; D014018:Tissue Distribution
D050607:Organogold Compounds; D009943:Organophosphorus Compounds; D010720:Phosphines; D006052:Gold Sodium Thiomalate; C016797:triethyl phosphine gold; D006046:Gold