The distribution of carcinogens, 4-nitroquinoline-1-oxide and 4-hydroxyaminoquinoline-1-oxide, in the nervous system and its possible neurotoxicological significance.
4-NQO-14C can enter the grey matter parenchyma of the central nervous system of mice after i.v. injection. The level of its uptake by the central grey is higher than that taken up by the central white and by the trigeminal and spinal dorsal root ganglia. This pattern of distribution is strikingly different from that obtained after i.v. injection of 4-HAQO-14C, suggesting the possible occurrence of 4-NQO encephalomyelopathy having entirely different sites of lesions from those of 4-HAQO neuropathy.
D015108:4-Hydroxyaminoquinoline-1-oxide / Q000378:metabolism* / Q000633:toxicity; D015112:4-Nitroquinoline-1-oxide / Q000378:metabolism* / Q000633:toxicity; D000634:Aminoquinolines / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000139:chemically induced; D005727:Ganglia, Spinal / Q000378:metabolism; D008297:Male; D051379:Mice; D009600:Nitroquinolines / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism; D013997:Time Factors
D000634:Aminoquinolines; D009600:Nitroquinolines; D015108:4-Hydroxyaminoquinoline-1-oxide; D015112:4-Nitroquinoline-1-oxide