Effect of morphine on the brain histamine levels in stress-exposed rats.
The effect of morphine on brain histamine levels in stress-exposed rats was investigated. It seemed that the brain histamine level was not directly affected by stressors. However, morphine induced a sharp rise in the brain histamine levels in both morphine-treated and morphine-treated stressed groups. This effect of morphine was reversed by naloxone.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005508:Food Deprivation; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013997:Time Factors
D009270:Naloxone; D009020:Morphine; D006632:Histamine