Anti-Rh39--a "new" specificity Rh system antibody.
Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C-negative individuals and ostensibly resembled anti-C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a "normal" Rh phenotype and on D--/D-- and Dc--/Dc--samples. The antigen detected is not present on Rhnull red blood cells. Serologic studies have shown that the new antibody, that has been named anti-Rh39, has a different specificity from those that define the antigens C, Ce(rhi), G, Hro, Hr, CG, LW, Rh:29, Rh:34 and U. A possible relationship between auto-anti-Rh39 and allo-anti-C, in terms of the immune response, is discussed.
D000327:Adsorption; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D003298:Coombs Test; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D012204:Rh-Hr Blood-Group System
D001323:Autoantibodies; D012204:Rh-Hr Blood-Group System