Hanganutziu-Deicher antigen and antibody in pathologic sera and tissues.
Heterophile, Hanganutziu-Deicher (H-D) antigen was studied in pathologic sera by means of inhibition of agglutination of bovine erythrocytes by H-D antibodies. H-D antigen was demonstrated in 38% of random cancer sera, 25% of lymphoma or leukemia sera, 25% of leprosy sera, 8% of infectious mononucleosis sera, 6% of rheumatoid arthritis sera, and 27% of synovial fluids of rheumatoid arthritis patients. None of 134 normal human sera gave positive results. Some of the inhibition-positive cancer sera formed precipitation lines with H-D antibody-containing sera. Over 50% of various extracts of cancer tissues as well as spleens of lymphoma or leukemia patients were shown to contain H-D antigen by means of the inhibition test.
D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002417:Cattle; D002499:Centrifugation, Density Gradient; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006801:Humans; D005779:Immunodiffusion; D007244:Infectious Mononucleosis / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D012756:Sheep