Occurrence of M-proteins in the CSF of a child with prolonged meningococcal meningitis.
CSF of a 4-month-old boy with prolonged, meningococcal meningitis revealed oligoclonal immunoglobulin G about 10 weeks after hospital admission. These proteins persisted for at least 4 months. In contrast to this child, a further 10 infants and young children with bacterial meningitis, whose CSF was examined between 4 weeks and 6 3/4 months subsequent to onset of the disease, showed no such abnormality. Since the presented boy was the only patient treated with a corticosteroid, his altered immune reaction could be related to the immunosuppressive effect of this drug.
D000293:Adolescent; D002555:Cerebrospinal Fluid / Q000166:cytology; D003907:Dexamethasone / Q000009:adverse effects; D004586:Electrophoresis; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid*; D043025:Oligoclonal Bands
D007136:Immunoglobulins; D043025:Oligoclonal Bands; D003907:Dexamethasone