[Differentiation and tumorigenicity of human malignant melanocytes. Comparative study of two "non pigmented" and pigmented lines from the same fibroblastoid cells].
A morphological, caryological and biochemical study of two established cell lines of human malignant melanocytes derived from the same original tumour, when compared with heterotransplantation results in nude Mice, showed that "non-pigmented" cells are more tumorigenic than pigmented cells. Differentiation and tumorigenicity, although concomitant, here seem to be two independent phenomena.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D010641:Phenotype; D010858:Pigmentation; D014183:Transplantation, Heterologous
Différenciation et tumorigénicité des mélanocytes malins humains. Etude comparée de deux lignées "achromique" et pigmentée issues des mêmes cellules fibroblastoïdes.