title: [Observations on antibacterial activity of thiamphenicol glycinate acetylcysteinate (author's transl)].
abstract: In vitro thiamphenicol antibacterial activity in the presence of N-acetylcysteine as sodium salt proved to be enhanced when compared with that of the antibacterial alone against both Gram-positive and Gram-negative bacterial strains. The in vitro results were confirmed in vivo in the guinea-pig, where the sera from animals previously treated by i.m. route with thiamphenicol glycinate acetylcysteinate, showed a higher antibacterial activity than sera from animals treated with thiamphenicol glycinate hydrochloride. The observation, even after allowing for differences between species might be of some interest in view of use of this chemotherapeutic agent in the treatment of respiratory infections.
mesh_terms: D000111:Acetylcysteine / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D004338:Drug Combinations / Q000097:blood / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007711:Klebsiella pneumoniae / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; C028814:thiamphenicol glycinate acetylcysteinate; D013839:Thiamphenicol; C028813:thiamphenicol glycinate; D000111:Acetylcysteine
vernacular_title: Osservazioni sull'attività antibatterica del tiamfenicolo glicinato acetilcisteinato.