Regulation of autoimmune response to mouse thyroglobulin: influence of H-2D-end genes.
Studies were initiated to define the H-2-linked genetic control of response to self-determinants of MTg. In addition to the Ir gene control of H-2K end, a modifying effect of D end was seen. The extent of regulation depended upon the derivation of the K-end Ir-Tg gene(s) as well as the D-end genes. When the Ir-Tg gene was from good responder H-2k and H-Ss strains, and the H-2D-end gene from the d allele, antibody levels were moderate to high but cellular infiltration was significantly reduced. These findings demonstrate genetic interaction between I-region and D-end gene products in the response to a self-antigen, MTg.
D000483:Alleles; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D004306:Dose-Response Relationship, Immunologic; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D011995:Recombination, Genetic; D013954:Thyroglobulin / Q000276:immunology*
D001323:Autoantibodies; D006183:H-2 Antigens; D013954:Thyroglobulin