Prolactin response to TRH after intravenous cimetidine.
Cimetidine administered intravenously to six healthy volunteers caused a significant increase in plasma prolactin response to TRH. The meaning of these results and their relation with the physiological role of histamine H2-receptors in the control of prolactin secretion is discussed.
D001812:Blood-Brain Barrier / Q000187:drug effects; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D006146:Guanidines; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D013973:Thyrotropin-Releasing Hormone; D002927:Cimetidine; D011388:Prolactin