[Non-amyloid nephrotic syndrome: first isolated manifestation of a kappa light chain myeloma (author's transl)].
The authors describe a case which demonstrates that nephrotic syndromes occuring during the course of a myeloma are not always of the amyloid type. They emphasize the possibility of a dysglobulinemia being involved in a glomerular nephropathy syndrome, especially when there are histological lesions of a glomerulosclerosis. The published literature is reviewed and the possible pathogenesis of these nephropathies briefly discussed: either protein deposits, the nature of which has not been fully determined, or mesangial modifications induced by the filtered light chains.
D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000652:urine*; D007145:Immunoglobulin kappa-Chains / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology / Q000652:urine; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000276:immunology
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains
Syndrome néphrotique non amyloïde: première manifestation, isolée, d'un myélome à chaînes légères kappa.