[Chloramphenicol and dextramycin, inhibitors of mammary carcinogenesis induced by 7,12-dimethylbenz(a)anthracene].
In noninbred rats chloramphenicol and its optical isomer dextramycin diminished the blastomogenic effect of 7,12-dimethylbenz(a)anthracene on mammary glands. The protective effect was shown by a decreased tumor incidence at all periods of observation and an increase in the life span of rats and in the case of dextramycin this action consisted in a prolongation of the latent period of tumor emergence.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D013237:Stereoisomerism
D015127:9,10-Dimethyl-1,2-benzanthracene; D002701:Chloramphenicol
Khloramfenikol i dekstramitsii: ingibitory kantserogeneza, vyzavannogo 7,12-dimetilbenz(a) antratsenom v molochnykh zhelezakh.