[Coating of centrospheres by reticulum cisternae and formation of spindle residues in segmentation mitosis under the action of an antitubulin substance: nocodazole].
When cleaving eggs are treated by nocodazole the reticulum cisternae coat the centrospheres instead of the chromosomes, as normally occurs at the late anaphase. At the same time the spindle is reduced to a common mass or spindle remnant, constituted of unorientated and fragmented microtubules which embed the kinetochores, i. e. the star configuration of the chromosomes. This action is quite similar to that of chloralhydrate but is different from that of colchicine.
D000705:Anaphase / Q000187:drug effects; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002502:Centrioles / Q000187:drug effects / Q000648:ultrastructure; D002697:Chloral Hydrate / Q000494:pharmacology; D002875:Chromosomes / Q000648:ultrastructure; D003078:Colchicine / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure; D008938:Mitosis / Q000187:drug effects*; D009940:Organoids / Q000648:ultrastructure*; D014319:Triturus / Q000196:embryology; D015053:Zygote / Q000648:ultrastructure*
D001562:Benzimidazoles; D002697:Chloral Hydrate; D003078:Colchicine
Enveloppement des centrosphères par des citernes de réticulum et formation de résidus fusoriaux dans les mitoses de segmentation sous l'influence d'une substance antitubuline, le nocodazole.