[Nonspecificity of antiviral protein action].
The authors studied the antiviral activity of the informative RNA of antiviral protein (M-RNA AVP) isolated from the cells following superinduction of interferon in them for the purpose of ascertaining the action specificity of the product of their translation--AVP. Following the administration of M-RAN AVP a marked (from 1 to 5 lg PFU/mil) reduction of the infectious titres was observed in the homologous and heterologous cells. RNA preparations from control (noninduced) cells possessed a weak (0.4--0.1 lg PFU/mil) antiviral activity.
D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D002645:Chickens; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects; D000882:Haplorhini; D006801:Humans; D007372:Interferons; D051379:Mice; D012333:RNA, Messenger / Q000494:pharmacology*; D013045:Species Specificity; D014776:Virus Cultivation
D000998:Antiviral Agents; D012333:RNA, Messenger; D007372:Interferons
Nespetsifichnost' deĭstviia antivirusnogo belka.