Quinazoline analogues of folic acid as inhibitors of thymidylate synthetase from bacterial and mammalian sources.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D007780:Lacticaseibacillus casei / Q000201:enzymology; D007939:Leukemia L1210 / Q000201:enzymology; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D011799:Quinazolines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D011799:Quinazolines; D005492:Folic Acid; D008780:Methyltransferases; D013940:Thymidylate Synthase