Irgasan-induced pigmentation in Serratia marcescens and Pseudomonas aeruginosa.
Two irgasan-resistant micro-organisms (P. aeruginosa and S. marcescens) were used to study the effects of various antibiotic and chemotherapeutic agents on pigment production. These agents included streptomycin, thallium acetate, polymyxin B, hexachlorophene, irgasan, prodigiosin and DMSO (dimethyl sulphoxide). Only irgasan, compared to other drugs and membrane-active agents showed the unique property of inducing pigmentation in both P. aeruginosa and S. marcescens, i.e. prodigiosin in S. marcescens and pyocyanin in P. aeruginosa.
D004305:Dose-Response Relationship, Drug; D006582:Hexachlorophene / Q000494:pharmacology; D010619:Phenazines / Q000096:biosynthesis*; D010647:Phenyl Ethers / Q000494:pharmacology*; D011112:Polymyxin B / Q000494:pharmacology; D011353:Prodigiosin / Q000096:biosynthesis* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism; D011710:Pyocyanine / Q000096:biosynthesis*; D012706:Serratia marcescens / Q000187:drug effects* / Q000378:metabolism; D013793:Thallium / Q000494:pharmacology; D014260:Triclosan / Q000494:pharmacology*
D010619:Phenazines; D010647:Phenyl Ethers; D014260:Triclosan; D011710:Pyocyanine; D013793:Thallium; D006582:Hexachlorophene; D011112:Polymyxin B; D011353:Prodigiosin