Mutagenic effects of vinyl chloride on Drosophila melanogaster with and without pretreatment with sodium phenobarbiturate.
Treatment of Drosophila males with 1--20% vinyl chloride in air gave an increased frequency of complete and mosaic recessive lethals. Pretreatment with phenobarbiturate for 24 h caused an increase in the mutagenic effect of vinyl chloride. This indicates that the mixed-function oxygenase system can be induced in Drosophila in the same way as in mammals.
D000818:Animals; D004331:Drosophila melanogaster; D004359:Drug Therapy, Combination; D005804:Genes, Lethal; D005808:Genes, Recessive; D008040:Genetic Linkage; D005821:Genetic Techniques; D008297:Male; D009153:Mutagens; D010634:Phenobarbital / Q000494:pharmacology*; D012730:Sex Chromosomes; D014752:Vinyl Chloride / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D009153:Mutagens; D014753:Vinyl Compounds; D014752:Vinyl Chloride; D010634:Phenobarbital