Cytomegalovirus strain differentiation by DNA restriction analysis.
The heterogeneity of CMV DNA obtained from standard strains and new isolates, including a vaccination strain (Towne 125), was investigated. The cleavage patterns produced by the restriction endonucleases Eco RI and Bam 1 revealed stable strain specificities of CMV. On the other hand, a remarkable homology of sequence-specific CMV DNA fragmentation was demonstrated. A CMV subtyping relevant to clinical questions seems to be improbable.
D000956:Antigens, Viral / Q000145:classification; D003587:Cytomegalovirus / Q000145:classification*; D004262:DNA Restriction Enzymes; D004279:DNA, Viral; D000939:Epitopes
D000956:Antigens, Viral; D004279:DNA, Viral; D000939:Epitopes; D004262:DNA Restriction Enzymes