Dextran anaphylactoid reaction in Sprague-Dawley CFY rats.
From a closed colony of randomly-bred Sprague-Dawley CFY rats about 23% failed to respond to intravenous dextran with the characteristic generalized anaphylactoid reaction, but still exhibited an inflammatory response when dextran was given into the foot pad. Brother-sister mating of rats showing the most expressed generalized reaction (reactor rats) yielded good responder offsprings, while the non-reactors had descendants completely unresponsive to systemic dextran. Brother-sister mating of selected non-reactor rats led to a gradual decrease in dextran paw oedema in the subsequent generations, and after the third mating, a complete local non-reactivity developed. In these rats the intradermal injection of dextran failed to increase vascular permeability, while the inflammatory response evoked by histamine, 5-HT, bradykinin, and compound 48/80 remained unchanged as compared to that of the reactor animals. These result show that the anaphylactoid reaction in Sprague-Dawley CFY rats is under genetic control.
D000707:Anaphylaxis / Q000139:chemically induced / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D002199:Capillary Permeability; D003911:Dextrans / Q000276:immunology; D005260:Female; D007428:Intradermal Tests; D008297:Male; D051381:Rats
D003911:Dextrans