Effects of perphenazine enanthate injections on prolactin levels in plasma from schizophrenic women and men.
Levels of prolactin (PRL) in plasma were determined in schizophrenic women and men after i.m. injections of 50-150 mg perphenazine enanthate (PE). In both sexes PRL levels increased dose-dependently. In men the effect was significant for 2 and in women for 9 days. Biperiden treatment did not influence the effect of PE on the PRL levels. The data support the view that clinically used doses of PE induce a small but significant blockade of central dopamine receptors.
D000368:Aged; D001712:Biperiden / Q000494:pharmacology; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010546:Perphenazine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012737:Sex Factors; D013997:Time Factors
D001712:Biperiden; D011388:Prolactin; D010546:Perphenazine