title: [Role of calcium in realization of nervous control during RNA synthesis in skeletal muscles].
abstract: The effects of Ca2+ on the RNA polymerase activity of the nuclei isolated from normal and denervated gastrocnemius muscles of the rabbit were studied. It was shown that 18 hrs after denervation the RNA synthesis in vitro, Ca2+ content and the Ca, Mg-ATPase activity of the nuclei are decreased. After addition of exogenous Ca2+ the incorporation of labelled UTP into the nuclei is stimulated in the denervated muscle and is inhibited in the control. Electrostimulation of the denervated muscle at the peripheral part of the sciatic nerve for 3 hrs increases both the RNA synthesis in the nuclei and the Ca2+ content, as well as the Ca, Mg-ATPase activity. Exogenous Ca2+ has an inhibitory effect on the nuclei of the stimulated muscle. The correlation established is indicative of participation of Ca2+ in the transmission of excitation in skeletal muscle sarcolemma to the processes occurring in nuclear structures.
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004558:Electric Stimulation; D008274:Magnesium / Q000494:pharmacology; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology* / Q000502:physiology; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D012584:Sciatic Nerve / Q000502:physiology
chemical_list: D012313:RNA; D012321:DNA-Directed RNA Polymerases; D000252:Calcium-Transporting ATPases; D008274:Magnesium; D002118:Calcium
vernacular_title: Rol'kal'tsiia v realizatsii nervnogo kontrolia sinteza RNK b skeletnykh myshtsakh.