Rapid and accurate stability-indicating assay for nitroglycerin.
A rapid high-pressure liquid chromatographic method for determining the nitroglycerin concentration in liquid dosage forms and intravenous admixture solutions is presented. A coefficient of variation of less than 1.8% was achieved over the concentration range most commonly encountered (50-500 microgram/ml). A variable wavelength detector (lambda = 218 nm) and a micro-alkyl phenyl column were employed. The mobile phase was acetonitrile-tetrahydrofuran-water (26:10:64). Total analysis time was 12 min.
D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004355:Drug Stability; D007275:Injections, Intravenous; D008722:Methods; D005996:Nitroglycerin / Q000032:analysis*; D012996:Solutions / Q000032:analysis
D004338:Drug Combinations; D012996:Solutions; D005996:Nitroglycerin