Mechanisms of generation of signals in vertebrate photoreceptors.
The electrical responses of rods are analyzed in different ionic environments. It is shown that the dark level of the membrane potential is predominantly determined by a sodium current, while the peak of responses to bright light is controlled by the concentration of external potassium. The sag from the peak to the plateau of photoresponses seems to be generated by different ionic mechanism. The effects produced by substituting the external calcium with EGTA are also analyzed. It is suggested that calcium plays a role in different mechanisms of generation of electrical responses.
D000818:Animals; D002023:Bufo bufo; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D010786:Photoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D004533:Egtazic Acid; D012964:Sodium; D011188:Potassium; D002118:Calcium