Isolation of ekatetrone, a new metabolite of producing variants of Streptomyces aureofaciens.
From a mixture of substances formed by producing strains of Streptomyces aureofaciens under conditions of submerged fermentation a new metabolite, ekatetrone, was isolated. Its isolation and basic physical and chemical data are described. Ekatetrone is a quinone derivative with a carboxamide group. In tests in vitro with cells of Ehrlich's ascites tumour evidence was provided that ekatetrone inhibits proteo- and nucleosynthesis.
D000818:Animals; D000880:Anthraquinones / Q000096:biosynthesis / Q000302:isolation & purification; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013304:Streptomyces aureofaciens / Q000378:metabolism*; D014633:Valine / Q000378:metabolism
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D014633:Valine