[18F]-labeled 3-deoxy-3-fluoro-D-glucose: synthesis and preliminary biodistribution data.
A cyclotron target system for the production of anhydrous [18F] fluoride ion has been developed and used for the synthesis of carrier-free [18F]-3-deoxy-3fluoro-D-glucose (3-FDG). The synthesis is sufficiently rapid and efficient to allow production of usable amounts of 3-FDG with a 6-MeV cyclotron. Preliminary animal studies show that 3-FDG is in fact a glucose analog.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002586:Cesium; D003837:Deoxy Sugars / Q000138:chemical synthesis*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism; D005461:Fluorine; D000882:Haplorhini; D007553:Isotope Labeling / Q000379:methods*; D008253:Macaca mulatta; D010315:Particle Accelerators; D011854:Radiochemistry; D011868:Radioisotopes; D014018:Tissue Distribution
D003837:Deoxy Sugars; D011868:Radioisotopes; D002586:Cesium; D005461:Fluorine; D003847:Deoxyglucose