Drugs that antagonize limb flick behavior induced by D-lysergic acid diethylamide (LSD) in cats.
In cats observed in their home cages limb flicks (LF) are a sensitive measure of the behavioral effects of LSD. LF induced by LSD (50 microgram/kg) were blocked by dextrorphan (0.6 mg/kg), dextromethorphan (0.6 mg/kg), and imipramine (5 mg/kg) at doses that did not produce ataxia or sleep. Levorphanol (0.6 mg/kg), a narcotic that is a congener of dextrorphan, did not block LF induced by LSD possibly because it produced an excitatory effect when given alone. Pentobarbital at low doses (2 and 4 mg/kg) increased the number of LF induced by LSD but at a high dose (8 mg/kg) decreased LF induced by LSD either by producing ataxia, so the cats tended to remain immobile, or by producing sleep. Chlorpromazine (CPZ) at three doses (2, 4, and 8 mg/kg) attenuated the effects of LSD on LF, but did not block LF as completely as the above three blocking drugs, and produced ataxia and sleep.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats; D002746:Chlorpromazine / Q000494:pharmacology; D003915:Dextromethorphan / Q000494:pharmacology; D003917:Dextrorphan / Q000494:pharmacology; D005260:Female; D005552:Forelimb; D007099:Imipramine / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology
D003917:Dextrorphan; D003915:Dextromethorphan; D008238:Lysergic Acid Diethylamide; D010424:Pentobarbital; D007099:Imipramine; D002746:Chlorpromazine