Sensitivity to apomorphine in the guinea pig as a function of age and body weight.
Male albino guinea pigs aged 4--10 weeks were challenged with 0.1, 0.2, and 0.4 mg/kg apomorphine. Mean stereotypy scores rose signfiicantly as a function of age. Stereotypy scores were better correlated with age than with body weight, suggesting that CNS maturation, rather than weight-related factors, were responsible. Although age and body weight were correlated, there was enough variability to make bvody weight an unreliable indicator of age.
D000375:Aging; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D001058:Apomorphine