The induction of sister chromatid exchanges by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene and 3-methylcholanthrene.
The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-K-region dihydrodiols. The most active compounds were the 3,4-dihydrodiol of 7,12-dimethylbenza[a]anthracene and the 7,8- and 9,10-dihydrodiols of 3-methylcholanthrene: the parent hydrocarbons and their corresponding K-region dihydrodiols were relatively less active. The results are consistent with others that suggest that the metabolic activation of both hydrocarbons proceeds through the conversion of non-K-region dihydrodiols into vicinal diol-epoxides.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism* / Q000494:pharmacology*; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects*; D006224:Cricetinae; D005260:Female; D008748:Methylcholanthrene / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D010053:Ovary
D001551:Benz(a)Anthracenes; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene