[Induction of sister chromatid exchanges in vivo in bone marrow cells of AKR mice].
Induction of sister chromatid exchanges (SCEs) in bone-marrow cells of AKR Mice receiving in vivo four drugs well-known for their mutagenesis activity has been tested. A decreasing activity in SCE was shown by the drugs tested in the order cyclophosphamide, procarbazine, methylmethane sulfonate and diethylnitrosamine. This technique presents an encouraging method for testing the effect of chemical agents in vivo.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001854:Bone Marrow Cells; D002842:Chromatids / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D004052:Diethylnitrosamine / Q000494:pharmacology; D005260:Female; D008297:Male; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D011344:Procarbazine / Q000494:pharmacology
D000477:Alkylating Agents; D011344:Procarbazine; D004052:Diethylnitrosamine; D003520:Cyclophosphamide; D008741:Methyl Methanesulfonate
Induction d'échanges entre chromatides soeurs in vivo sur les cellules de moelle osseuse de souris AKR.