title: Effects of intrafollicular administration of gonadotropins in two species of nonhuman primates using laparoscopy.
abstract: Direct administration of 0.5 IU of human chorionic gonadotropin (HCG) into the matured ovarian follicles of adult female Saimiri sciureus resulted in ovulation in 45% of the animals treated. When purified ovine luteinizing hormone (LH) was administered, ovulation was observed in 55% of the animals while intrafollicular injection of saline had no effect. Similar injections of HCG into matured follicles of Macaca fascicularis would not cause ovulation but did result in a 55% increase in menstrual cycle length. These results indicate that the necessity of a primate source of LH for inducing ovulation may be due to an extrafollicular mechanism.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D000882:Haplorhini / Q000502:physiology*; D007267:Injections; D007813:Laparotomy / Q000662:veterinary; D007986:Luteinizing Hormone / Q000494:pharmacology; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects; D010062:Ovulation Induction / Q000662:veterinary*; D012453:Saimiri / Q000502:physiology*
chemical_list: D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone