[New data on the tachyphylactic properties of sodium nucleinate].
Sodium nucleinate, when injected into mice in combination with killed E. coli or prodigiozan, caused a decrease in side effects produced by the vaccine or polysaccharide. The combined injection of sodium nucleinate and prodigiozan in doses, ineffective if introduced separately, was accompanied by the potentiation of their tachyphylactic action. The use of sodium nucleinate in combination with polyvinylprrolidone (hemodez) prolonged the tachyphylactic action of sodium nucleinate and increased its effectiveness. The proposed principle is supposed to be suitable for decreasing the reactogenicity of bacterial vaccines and polysaccharides.
D000818:Animals; D001428:Bacterial Vaccines / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D004357:Drug Synergism; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli / Q000276:immunology; D007709:Klebsiella / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009696:Nucleic Acids / Q000276:immunology*; D011354:Prodigiozan / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000276:immunology; D013268:Stimulation, Chemical; D013618:Tachyphylaxis
D001428:Bacterial Vaccines; D004731:Endotoxins; D009696:Nucleic Acids; D011354:Prodigiozan
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