title: [Thrombocytopenic purpura during heparinotherapy. Two cases (author's transl)].
abstract: In two patients treated by heparin for thrombosis, thrombocytopenia under 10 000/cumm occured accompanied with bleeding cud recurrent thrombosis. The demonstration in the patients' serum of a factor inducing platelet aggregation and serotonin release in the presence of heparin suggests that the thrombocytopenia could be of immuno-allergic origin. In both cases, the discontinuation of heparin resulted in clinical and biological improvement. The rare cases of heparin-induced thrombocytopenia reported in the literature are discussed.
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D010974:Platelet Aggregation; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced*; D012701:Serotonin / Q000097:blood; D013921:Thrombocytopenia / Q000276:immunology; D013924:Thrombophlebitis / Q000188:drug therapy; D005719:gamma-Globulins
chemical_list: D005719:gamma-Globulins; D012701:Serotonin; D006493:Heparin; D007770:L-Lactate Dehydrogenase
vernacular_title: Purpura thrombopénique lors d'une héparinothérapie. Deux observations.