Chromosome changes (trisomy 15) in murine T-cell leukemia induced by 1,12-dimethylbenz(a)anthracene (DMBA).
The banding pattern of DMBA-induced leukemias in C57BL/6 mice revealed a very constant chromosome pattern: the presence of trisomy 15 in almost all leukemic cells. This finding strongly suggests that chromosome 15 trisomy is the first detectable specific chromosome change associated with the development of DMBA-induced T-cell lymphomas. A similar association was previously shown with regard to development of radiation-leukemia-virus-induced T-cell lymphoma. It is conceivable that in tumors of diverse etiologies common cytogenetic changes may appear in the same common target-cell precursor, by a process of the "convergent microevolution" type.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001551:Benz(a)Anthracenes; D002871:Chromosome Banding; D002875:Chromosomes / Q000187:drug effects*; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D008677:Metaphase; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000648:ultrastructure; D014185:Transplantation, Isogeneic; D014314:Trisomy
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene