[Unmasking of the fast sodium channel in less than 4 day old embryonic chicken heart by inhibitors of sodium inactivation].
Embryonic Chick hearts aged less than 4 days are not always sensitive to tetrodotoxin, an inhibitor of fast sodium channel. It is shown that in the most frequent cases, in which tetrodotoxin sensitivity is apparently absent, this sensitivity can be demonstrated after previous treatment by veratridine or by toxin II of androctonus australis Hector Scorpion venom. It is concluded that the fast tetrodotoxin-sensitive sodium channel is regularly present in the heart of Chick embryos aged 2 and 3 days, but most often in a permanently inactivated state.
D000818:Animals; D002642:Chick Embryo; D006321:Heart / Q000196:embryology; D007473:Ion Channels / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D012604:Scorpion Venoms / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology*; D013997:Time Factors; D014701:Veratridine / Q000494:pharmacology
D007473:Ion Channels; D012604:Scorpion Venoms; D013779:Tetrodotoxin; D014701:Veratridine; D012964:Sodium
Démasquage du canal sodium rapide chez le coeur d'embryon de poulet de moins de 4 jours sous l'action d'inhibiteurs de l'inactivation sodique.