Cholic acid accumulation by the ciliary body and by the iris of the primate eye.
Cholic acid accumulates in both the ciliary body and the iris of the primate eye during in vitro incubations at 37 degrees C for 1 hr. Incubation at 0 degrees C depresses uptake in both tissues. The washout of preaccumulated cholic acid occurs some 3.4 times faster from the iris than from the ciliary body. The mechanism of cholic acid accumulation in both tissues is less sensitive to inhibition by high iodipamide concentrations and also is less sensitive to inhibition by high hippurate concentrations than the mechanism of p-aminohippurate (PAH) accumulation. Therefore, although overlap may exist, the cholic acid--uptake mechanism differs from the PAH-uptake mechanism in both the primate ciliary body and the primate iris.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002793:Cholic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002924:Ciliary Body / Q000378:metabolism*; D004140:Dinitrophenols / Q000494:pharmacology; D000882:Haplorhini; D006626:Hippurates / Q000494:pharmacology; D007458:Iodipamide / Q000494:pharmacology; D007498:Iris / Q000378:metabolism*; D008253:Macaca mulatta; D011817:Rabbits
D002793:Cholic Acids; D004140:Dinitrophenols; D006626:Hippurates; D007458:Iodipamide