[Origin of a mitogrenic factor for cultivated macrophages (IMF: Inflammatory Mitogenic Factor) found in exudates of non-specific acute inflammation].
The mitogenic activity of inflammatory exudate obtained from irradiated Rats is reduced. After transfer of bone marrow syngeneic cells into irradiated Rats this mitogenic activity is further decreased, while after transfer of thymic cells it is increased. It is postulated that the mitogenic activity of inflammatory exudate could be related to thymic cells and that T lymphocytes may be involved in non specific-inflammatory reactions.
D000208:Acute Disease; D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D002588:Cesium Radioisotopes; D004247:DNA / Q000096:biosynthesis; D005122:Exudates and Transudates / Q000276:immunology / Q000528:radiation effects; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism* / Q000528:radiation effects; D008222:Lymphokines / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
D002588:Cesium Radioisotopes; D007376:Interleukin-2; D008222:Lymphokines; D004247:DNA
Recherche sur l'origine d'un facteur mitogène pour les macrophages en culture (I.M.F.: Inflammatory Mitogenic Factor) présent dans des exsudats d'inflammations aiguës non spécifiques.