[Consumption hypocomplementemia: comparative value of haemolytic and protein estimations of the components of the classical pathway (author's transl)].
Titrations of total complement (CH50) and of the different components of the classical pathway of the complement system in patients with supposed consumption hypocomplementemia, show that the complement depression involves in an order of decreasing severity hemolytic C4, hemolytic C2, total complement, hemolytic C1, protein C4 and protein C3. These results as well as correlative studies between these different parameters suggest that C4 is the most specific target of activited C1 esterase (C1s). They stress the interest of hemolytic titrations as well as the strong limitations of protein titrations.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001796:Blood Protein Disorders / Q000175:diagnosis*; D002648:Child; D003167:Complement Activation; D003172:Complement C1 / Q000032:analysis; D003173:Complement C1s / Q000502:physiology; D003175:Complement C2 / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003168:Complement Fixation Tests / Q000379:methods; D003171:Complement Pathway, Classical; D003165:Complement System Proteins / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged
D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins; D003173:Complement C1s
Hypocomplémentémies de consommation: intérêt comparé des dosages hémolytiques et protéliques des composants de la voie classique du complément.