Inhibition of 3'-methyl-4-dimethylaminoazobenzene (3'MeDAB)-induced hepatocarcinogenesis in the rat: chloramphenicol inhibits N,N-dimethylaniline N-oxidase and in vitro binding of [3H]3'MeDAB to protein but not to RNA.
D000814:Aniline Compounds; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D004032:Diet; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D008749:Methyldimethylaminoazobenzene / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D011485:Protein Binding / Q000187:drug effects; D012313:RNA / Q000378:metabolism; D051381:Rats; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives*
D000814:Aniline Compounds; D008749:Methyldimethylaminoazobenzene; D012313:RNA; D002701:Chloramphenicol; D004124:p-Dimethylaminoazobenzene; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)