Sudanophilic lipid accumulation in astrocytes in periventricular leukomalacia in monkeys.
Sudanophilic lipid accumulation is a characteristic feature of periventircular leukomalacia (PVL) of infants. At least two types of lipid-containing cells have been identified, one being the macrophage, the other the "pre-myelin glial cell". A third type of lipid-containing cell has been seen in two monkeys with spontaneous PVL. Electron microscopically this cell appears to be an astrocyte. This probably represents a reaction of the astrocyte to hypoxia and may be the equivalent of the "hypertrophic" astrocytes found in human infants.
D000818:Animals; D001253:Astrocytes / Q000032:analysis* / Q000648:ultrastructure; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D000882:Haplorhini; D000860:Hypoxia; D008055:Lipids / Q000032:analysis*; D008251:Macaca; D008854:Microscopy, Electron; D009336:Necrosis
D008055:Lipids