[Acute renal failure in the course of occupational lead intoxication. Chelation therapy responsability (author's transl)].
In a patient with occupational plumbism and a normal kidney function, EDTA therapy (1 g/24 h) resulted in a massive lead excretion (15 000 microgram/24 h) together with acute renal failure. A direct nephrotoxic effect of EDTA was excluded: after renal function returned to normal, EDTA could be subsequently readministered at progressively increasing doses (250 mg to 1 g/24 h) without any renal dysfunction. These findings strongly suggest a close relationship between the burden of lead mobilized by EDTA and the acute renal failure. This case can be classified as acute lead nephropathy of which only a few instances have been reported in the literature. The interest of monitoring lead excretion during chelation therapy is particularly emphasized.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D004492:Edetic Acid / Q000627:therapeutic use*; D006801:Humans; D008658:Inactivation, Metabolic; D007855:Lead Poisoning / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*
D004492:Edetic Acid
Insuffisance rénale aiguë au cours d'un saturnisme professionnel. Responsabilité du traitement chélateur.