Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats, and guinea pigs.
Syngeneic tumour transplants to inbred female animal strains were carried out with basaliomas, squamous cell carcinomas and fibrosarcomas of the skin, induced by DMBA (9,10-dimethyl-1,2-benzanthracene) in the mouse, rat and guinea pig. A completely successful transplantation of all tumors was only achieved in the group of fibrosarcomas of the rat when a myocardial suspension of a young rat was used as a "supporting agent". This may be a new immuno-biological aspect in tumor transplantation. In the other groups, five tumors developed in the host animals after a period of latency of 10 months or more. Therefore, it is discussed whether two of these tumors grown in the host rats should be considered spontaneous. In addition I have found no earlier reports in the literature with successful DMBA-induced epidermal tumors transplantations in homologous or syngeneic animal strains. Tumors were grafted on to altogether 100 animals.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D006168:Guinea Pigs; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation / Q000379:methods*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013045:Species Specificity; D014185:Transplantation, Isogeneic
D015127:9,10-Dimethyl-1,2-benzanthracene