[Experience in using P. hamadryas for assessing the effectiveness of a peroral vaccination method against plague].
For the first time P. hamadryas were used for studying the effectiveness of oral immunization with dried live plague vaccine. Oral immunization was shown to produce morphological changes in the organs and tissues of the monkeys, which indicated the immune transformation of the organism. The challenge of the immunized animals with the infective agent introduced in aerosol showed the effectiveness of the inhalation and oral methods of immunization. P. hamadryas proved to be a suitable model for the evaluation of the effectiveness of oral vaccination. A more precise quantitative evaluation of the effectiveness of oral vaccination against plague requires further research.
D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D004353:Drug Evaluation, Preclinical; D000882:Haplorhini; D008198:Lymph Nodes / Q000473:pathology; D010215:Papio / Q000276:immunology*; D010930:Plague / Q000473:pathology / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage; D013997:Time Factors; D014611:Vaccination / Q000379:methods*
D000336:Aerosols; D010931:Plague Vaccine
Opyt ispol'zovaniia P. hamadryas dlia otsenki éffektivnosti peroral'nogo sposoba vaktsinatsii protiv chumy.