Emergence of trimethoprim-resistant enterobacteria in patients receiving long-term co-trimoxazole for the control of intractable urinary-tract infection.
In patients with previously intractable urinary-tract infection treated with low-dose co-trimoxazole for 6--58 (mean 32.7) months, the percentage of infected urines fell from 41.4 before treatment to 6.3 during treatment. Only 6 episodes of infection were due to trimethoprim-resistant bacteria. Results in a small group of patients in whom treatment was continued with trimethoprim alone were similar. Under the conditions of this study, long-term control of urinary-tract infection was not materially compromised by breakthrough infections due to trimethoprim-resistant organisms.
D001437:Bacteriuria / Q000188:drug therapy*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D010957:Plasmids / Q000187:drug effects; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000008:administration & dosage / Q000494:pharmacology*
D014295:Trimethoprim; D013420:Sulfamethoxazole