[Bioavailability of orally administered antibiotics: influences of food on resorption (author's transl)].
After the administration of a liquid suspension of Penicillin V-K, Epicillin, Cephalexin, Ampicillin, Pivampicillin and Amoxycillin on fasting and not fasting children, plasma levels and urine excretion of antibiotics were determined. A standard meal influences in Penicillin V-K and Ampicillin not only the maximum plasma levels, but also the absorbed amount of the drug. In Epicillin, Pivampicillin and Cephalexin we were not able to detect an influence of food on absorption. Amoxycillin doesn't seem to be impaired by food. However, the considerable individual differences could have its reasons in a number of other factors presently investigated.
D000658:Amoxicillin / Q000378:metabolism; D000667:Ampicillin / Q000031:analogs & derivatives / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism*; D002506:Cephalexin / Q000378:metabolism; D005215:Fasting; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D010404:Penicillin V / Q000378:metabolism; D010917:Pivampicillin / Q000378:metabolism; D013535:Suspensions
D000900:Anti-Bacterial Agents; D013535:Suspensions; D010917:Pivampicillin; D000667:Ampicillin; D000658:Amoxicillin; D002506:Cephalexin; D010404:Penicillin V
Resorptionsbeeinflussung oraler Antibiotika in Saftform durch Nahrungsmittel.