The dorsal noradrenergic bundle and varieties of passive avoidance.
Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by testing 24 h post-operation) and by using the F-344 strain of rat which does not show denervation supersensitivity as measured by NA-sensitive adenylate cyclase. Nonassociative freezing to electric footshock, changed by the injections, resulted in slower acquisition at a footshock level 4 mA, but not at 1 mA.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D004597:Electroshock; D004924:Escape Reaction / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009434:Neural Pathways / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344
D000262:Adenylyl Cyclases; D009638:Norepinephrine