Adrenergic and dopaminergic response to chronic chair restraint in the rhesus monkey.
Prolonged chair restraint and social isolation in the rhesus monkey led to a reduction in the urinary excretion of HVA (4-hydroxy-3-methoxyphenylacetic acid), DOPAC (3,4-dihydroxyphenylacetic acid), VMA methoxy-4-hydroxymandelic acid), and MHPG (3-methoxy-4-hydroxyphenylethylglycol) over a 3 week period. This adaptation to a chronically "stressful" situation corresponds to earlier studies on the rhesus monkey indicating a gradual reduction in the urinary excretion of norepinephrine and epinephrine after initiation of restraint. The following basic information on the urinary excretion of catecholamine metabolites was obtained: (1) the rate of excretion of the dopamine metabolites (HVA and DOPAC) is about four times higher than the rate of excretion of adrenergic metabolites (VMA and MHPG): (2) MHPG is the major adrenergic metabolite in the rhesus monkey; and (3) the excretion rates of the urinary metabolites varied considerably between animals.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000652:urine; D000818:Animals; D002395:Catecholamines / Q000652:urine*; D000882:Haplorhini; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D008251:Macaca / Q000652:urine*; D008253:Macaca mulatta / Q000652:urine*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D012149:Restraint, Physical; D012934:Social Isolation; D013315:Stress, Psychological / Q000652:urine*; D013997:Time Factors; D014642:Vanilmandelic Acid / Q000652:urine
D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D014642:Vanilmandelic Acid; D006719:Homovanillic Acid