Chemical occlusion of rhesus monkey oviducts with chloroquine.
Fertility control through chemical occlusion of the oviducts with chloroquine was investigated in rhesus monkeys (M.m.). Chloroquine was instilled retrograde through the tubal ostium after laparotomising the monkeys as a 10, 50 and 100% suspension (w/v) in aqueous carboxymethyl cellulose (CMC) solution which was used as a carrier vehicle. Complete occlusion of the Fallopian tubes at the uterotubal junction and also the intramural portions resulted in 15 days after a single instillation.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D010057:Oviducts / Q000187:drug effects* / Q000473:pathology
D002738:Chloroquine