title: Excretion and biotransformation of carboxymethyl-cysteine in rat, dog, monkey and man.
abstract: 1. Following an oral dose of S-carboxymethyl [35S]cysteine monkey (rhesus and African green), rat, dog, and man excreted 77,88,95, and 100% respectively of the 35S radioactivity in urine and 7.0, 2.5, 0.7, and 0.3% in faeces during a 3 to 4 day period. 2. The principal drug-related components excreted were unchanged carboxymethylcysteine, dicarboxymethyl sulphide and inorganic sulphate. 3. Rat, dog, and man excreted primarily dicarboxymethyl sulphide and unchanged carboxymethylcysteine and no inorganic sulphate (rat, 7%). 4. Monkey excreted largely inorganic sulphate, moderate amounts of dicarboxymethyl sulphide and a trace of unchanged drug.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002233:Carbocysteine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003545:Cysteine / Q000031:analogs & derivatives*; D004285:Dogs; D005243:Feces / Q000032:analysis; D005260:Female; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D002233:Carbocysteine; D003545:Cysteine