Synthesis and biological properties of 9-deoxo-16,16-dimethyl-9-methylene-PGE2.
The in vivo monkey uterine stimulating potency of 9-deoxy-16,16-dimethyl-9-methylene-PGE2 is similar to that of 16,16-dimethyl-PGE2 and approximately 15 times that of PGE2. Low doses of this compound stimulated uterine contractions when administered vaginally. Pregnancy was terminated prematurely following subcutaneous, intramuscular or vaginal suppository treatment. Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
D000028:Abortion, Induced; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003106:Colon / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004951:Esterification; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D005849:Gerbillinae; D000882:Haplorhini; D006868:Hydrolysis; D008253:Macaca mulatta; D010084:Oxidation-Reduction; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects*
D011459:Prostaglandins E, Synthetic