Anthracene with near ultraviolet light inhibiting epidermal proliferation.
Anthracene plus near ultraviolet (UV) light (UV-A, 320 to 400 nm) suppresses DNA synthesis and mitosis in mouse epidermis. Ultraviolet-A light or anthracene alone does not have any effect. There is no photoactivation of anthracene to enhance depression of DNA synthesis by either UV-B (290 to 320 nm) or UV-C (254 nm) light. While methoxsalen with UV-A light inhibits DNA synthesis, the phototoxic drugs chlorpromazine hydrochloride and demethylchlortetracycline do not. The combination of anthracene plus UV-A light may have therapeutic effectiveness for psoriasis with less potential for photocarcinogenesis than psoralens plus UV-A light.
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D003707:Demeclocycline / Q000494:pharmacology; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects* / Q000528:radiation effects; D008730:Methoxsalen / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D008954:Models, Biological; D014466:Ultraviolet Rays
D000873:Anthracenes; D003707:Demeclocycline; D004247:DNA; D002746:Chlorpromazine; D008730:Methoxsalen