Sideroblastic anaemia and leukaemia in multiple myeloma.
Two patients with IgA myeloma and one patient with kappa light chain disease developed sideroblastic anaemia from two to four years after the initial diagnosis. All had previously received radiotherapy and chemotherapy (melphalan and prednisone). In two patients the myeloma was quiescent when the sideroblastic change occurred. Leukaemia occurred in two patients two and seven months respectively after the diagnosis of sideroblastic anaemia was made. In one of them, the myeloma became active again at the same time. The development of sideroblastic anaemia may be a pre-leukaemic event and may be recognised by the appearance of a dimorphic blood film.
D000756:Anemia, Sideroblastic / Q000209:etiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D007938:Leukemia / Q000209:etiology*; D008297:Male; D008558:Melphalan / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology / Q000628:therapy; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D011289:Preleukemia
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D008558:Melphalan; D011241:Prednisone