[Antitumor resistance induced by immunization with normal definitive tissues].
Immunization of C3HA mice with homogenates of various normal definitive tissues, obtained from syngeneic, allogeneic and xenogeneic donors, resulted in an increase of antitumor resistance, as evidenced by a considerable retardation of growth of the transplantable strain-specific hepatoma 22a. The effect may be due to sensibilization of animals to the antigens of normal definitive cells, and, in particular to the tissue-specific antigens characteristic of cells of the tumor in question.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D000939:Epitopes; D007109:Immunity; D007114:Immunization / Q000379:methods*; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D008168:Lung / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000276:immunology; D009368:Neoplasm Transplantation; D051381:Rats; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D000941:Antigens; D000939:Epitopes
K issledovaniiu protivoopukholevoĭ rezistentnosti, vyzvannoĭ immunizatsieĭ normal'nymi definitivnymi tkaniami.