Immunologically active zones in bovine growth hormone.
Antigenic determinant areas were detected in bovine growth hormone fragments 6--124 and 125--149, the former being predominant. Reduction and carboxymethylation of disulfide bridge 53--164 destroys the immunological reactivity of the area which is little affected by reduction and carbamoylmethylation. All the activity found in fragment 6--124 seems to be concentrated in the sequence 87--124.
D000818:Animals; D002417:Cattle; D003168:Complement Fixation Tests; D000939:Epitopes; D013006:Growth Hormone / Q000032:analysis / Q000276:immunology*; D006384:Hemagglutination; D006385:Hemagglutination Inhibition Tests; D006736:Horses; D006801:Humans; D010446:Peptide Fragments / Q000032:analysis
D000939:Epitopes; D010446:Peptide Fragments; D013006:Growth Hormone