title: Clinical pharmacokinetics of nitroxoline.
abstract: 14C-Nitroxoline was given orally to the rats, and its distribution as well as plasma and bile levels were determined autoradiographically and by the aid of radioactivity measurements, respectively. Nitroxoline was also given to the human volunteers orally and intravenously in three various doses and the corresponding urine concentrations of unconjugated and conjugated nitroxoline were determined spectrophotometrically. A pharmacokinetical model was generated on the basis of the results. The curve fitting procedure between total nitroxoline cumulative quantities in urine and the model response simulated on analog-hybrid computer enabled the evaluation of the validity of the chosen model as well as of the identification of its parameters.
mesh_terms: D000328:Adult; D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001345:Autoradiography; D001646:Bile / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009600:Nitroquinolines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism / Q000652:urine; D051381:Rats; D013997:Time Factors
chemical_list: D000892:Anti-Infective Agents, Urinary; D009600:Nitroquinolines; D015125:Oxyquinoline; C005308:nitroxoline