Experimental studies on the mechanism of the nitroglycerin effect.
The regional decrease of the speed and extent of the contraction and the relaxation of the canine myocardium induced by coronary ligation was enhanced by intravenously administered nitroglycerin (GTN), simultaneously with the decrease of the left ventricular pressure, while the increase of myocardial fiber length caused by that procedure was partly abolished. The above changes could be reproduced by GTN applied directly onto the ischaemic myocardial surface even before the decrease of the left ventricular pressure. These changes induced by GTN might play a role in the decrease or abolishment of regional asynergic wall motion.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D003864:Depression, Chemical; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D013599:Systole; D016276:Ventricular Function
D005996:Nitroglycerin