title: [Effect of pindolol on tachycardia and certain metabolic variations dependent of muscular exertion].
abstract: 1. -- In young well trained adults, adrenergic beta receptors blockade by pindolol or propranolol causes a relative bradycardia during running on a threadmill during 10 to 20 min at 50% VO2 max. 2. -- Pindolol activity is maximum for 5-7.5 mg ingested one hour before starting. In two subjects, tachycardia reappears for 30 mg : this secondary increase may be explained by an intrinsic sympathetic activity of pindolol. 3. -- Propranolol is about 14 times less active than pindolol without any intrinsic sympathetic activity.
mesh_terms: D000328:Adult; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D005082:Physical Exertion / Q000187:drug effects*; D010869:Pindolol; D011433:Propranolol
chemical_list: D011433:Propranolol; D010869:Pindolol
vernacular_title: Influence du pindolol sur la tachycardie et sur certaines variations métaboliques liées à l'exercice musculaire.