Enhancement by caffeine of sister-chromatid exchange frequency induced by antineoplastic agents in human lymphocytes.
The SCE frequency induced by Thiotepa and the effect of this antineoplastic drug in combination with caffeine have been studied in cultures of human peripheral blood. Caffeine was found to enchance SCE and breakage frequencies induced by Thiotepa in human lymphocytes.
D002110:Caffeine / Q000494:pharmacology*; D002842:Chromatids / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D013852:Thiotepa / Q000494:pharmacology*; D013997:Time Factors
D002110:Caffeine; D013852:Thiotepa