title: Cytogenetic localisation of the purine 1 and guanosine 1 loci of Drosophila melanogaster; the purine 1 locus specifies a vital function.
abstract: Three auxotrophic mutants at two loci (pur 1 and gua 1) apparently involved in purine metabolism were mapped cytologically to region 9E1-9E3 on the X-chromosome of Drosophila. Because mutants of pur 1 behaved as semi-lethals against deficiencies even on permissive medium, it appears that the pur 1 locus is vital to the fly and its auxotrophic mutants are hypomorphs.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005796:Genes; D006151:Guanosine / Q000235:genetics*; D009154:Mutation; D011687:Purines; D014960:X Chromosome
chemical_list: D011687:Purines; D006151:Guanosine