Urinary 4-hydroxy-3-methoxyphenylglycol is not a predictor for clinical response to amitriptyline in depressive illness.
The urinary excretion of 4-hydroxy-3-methoxyphenylglycol was compared in a group of 23 depressive patients and 27 control subjects of similar age. There was no difference between patients and controls although female controls excreted less than males. After 6 weeks' treatment with 150 mg daily of amitriptyline there was no correlation between therapeutic response and pretreatment urinary excretion value.
D000639:Amitriptyline / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000652:urine; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D012737:Sex Factors
D006018:Glycols; D000639:Amitriptyline; D008734:Methoxyhydroxyphenylglycol