Peters' anomaly: dominant inheritance in one pedigree and dextrocardia in another.
Two case reports are described to illustrate the unusual occurrence of dominant inheritance of Peters' anomaly and the concomitant occurrence of Peters' anomaly with colobomatous microphthalmos and dextrocardia. Studies of additional families are necessary to determine conclusively the pathogenesis, genetic mode of inheritance, ocular and systemic associated malformations, and proper management of this complex entity.
D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003103:Coloboma / Q000150:complications; D000013:Congenital Abnormalities / Q000235:genetics*; D003316:Corneal Diseases / Q000150:complications; D003914:Dextrocardia / Q000150:complications; D004483:Ectropion / Q000150:complications; D005124:Eye Abnormalities; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007498:Iris / Q000002:abnormalities; D008297:Male; D008850:Microphthalmos / Q000150:complications; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013285:Strabismus / Q000150:complications; D014188:Transposition of Great Vessels / Q000150:complications