[Delayed implantation and early developmental defects in the mouse caused by PCB: 2,2'-dichlorobiphenyl (author's transl)].
Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on the investigations during the early development it is concluded, that retardation of the fetus is caused by a delayed implantation. It is assumed, that increased resorption is due to kyematopathies detected during the periimplantation period.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D051379:Mice; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D011247:Pregnancy; D013997:Time Factors
D011078:Polychlorinated Biphenyls
Verzögerte Implantation und frühembryonale Keimschäden bei der Maus nach Applikation des PCB: 2,2'-Dichlorbiphenyl.