Immunological features and corticosteroid therapy of midline granuloma.
This paper presents treatment of midline granuloma with corticosteroids and immunological features of this disease. The cellular immunity state of this patient was examined by counting T cell subpopulation and lymphocyte blastformation index (BI) by phytohemagglutinin at various time intervals during the corticosteroid therapy. Consequently, the percentage of T cells and BI became greatly increased according to the subsiding of the primary lesion, whereas non-T cell production and its function were depressed. In this communication we discuss a possible autoantibody mechanism and impared lymphocyte transformation in midline granuloma.
D002610:Cheek; D006103:Granuloma, Lethal Midline / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D011859:Radiography; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D011239:Prednisolone