Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli.
Under conditions where a maximum stimulation of 3-O-methyl-glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra-membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002462:Cell Membrane / Q000648:ultrastructure; D003208:Concanavalin A / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D008757:Methylglucosides / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D008934:Mitogens / Q000494:pharmacology*; D009997:Osmotic Pressure; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*
D008757:Methylglucosides; D008934:Mitogens; D003208:Concanavalin A; D000001:Calcimycin; D006861:Hydrogen Peroxide