Further evidence for a role of secretory component (SC) and J chain in the glandular transport of IgA.
These studies support the transport model depicted in Figure 3: Incorporation of J chains into dimeric IgA induces a configurational fit allowing complexing of IgA with SC available in the plasma membrane of serous secretory epithelial cells. This complexing on the surface of the cell stimulates pinocytosis, and the completed secretory IgA molecules are transported in cytoplasmic vesicles to the gland lumen. The same transport model can be applied for the external translocation of IgM.
D000293:Adolescent; D003106:Colon; D006362:Heavy Chain Disease / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007128:Immunoglobulin Fragments / Q000378:metabolism*; D007144:Immunoglobulin J-Chains / Q000502:physiology*; D007075:Immunoglobulin M / Q000378:metabolism; D007137:Immunoglobulin alpha-Chains; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D011485:Protein Binding; D012635:Secretory Component / Q000378:metabolism*
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007128:Immunoglobulin Fragments; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; D007137:Immunoglobulin alpha-Chains; D012635:Secretory Component