title: Alteration in thermal stability of ribosomes from Drosophila melanogaster with age.
abstract: Thermal analysis of high salt (0.5 M) washed ribosomal monomers from young and old male Drosophila melanogaster revealed an 8 degrees C downshift in the mean temperature of denaturation (Tm). Moreover, there was observed a marked loss in the ability of ribosomes extracted from older flies to reassociate upon cooling. These observations suggest that age-dependent alterations in the structural integrity of the rRNA-r protein complex could, at least in part, be responsible for the diminished capacity for protein synthesis in this species with advancing age.
mesh_terms: D000375:Aging; D000818:Animals; D004331:Drosophila melanogaster / Q000254:growth & development*; D004355:Drug Stability; D008297:Male; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; D012270:Ribosomes / Q000648:ultrastructure*; D013696:Temperature
chemical_list: D012335:RNA, Ribosomal; D012269:Ribosomal Proteins