[Evaluation of the immunogenicity of meningococcal vaccines in experiments on mice].
The immunogenicity of 2 meningococcal vaccines, multicomponent vaccine produced at the Mechnikov Research Institute for Vaccines and Sera in Moscow and polysaccharide vaccine obtained from Merck Sharp & Dohme (USA), was evaluated on experimental meningococcal sepsis in mice, produced by the injection of meningococcal culture in mucin suspension. The protective effect of these 2 vaccines, expressed in terms of ED50, was 0.28 +/- 0.12 for the multicomponent vaccine and 0.25 +/- 0.24 for the polysaccharide vaccine; the challenge dose used in the test was 10 LD50 of the culture. The multicomponent vaccine gave the maximum immunological effect in a dose of 8 micrograms, while higher or lower doses induced a lesser increase in antibody titer and thus gave lower protection to mice against infection.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D001428:Bacterial Vaccines / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007110:Immunity, Active / Q000187:drug effects; D007114:Immunization; D008297:Male; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D009345:Neisseria meningitidis / Q000276:immunology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Otsenka immunogennosti meningokokkovykh vaktsin v opytakh na myshakh.