title: 3-Phenyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]indole-2-carbonitrile, a potent inhibitor of prostaglandin synthetase and of platelet aggregation.
abstract: A number of indoles containing the 2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl side chain have been prepared by standard methods. Alternate, novel syntheses of indole-2-carboxamides and indole-2-carbonitriles have been developed. The title compound, 7e, was found to be a potent inhibitor of bovine prostaglandin synthetase in vitro and to lower serum prostaglandin levels after oral or intraperitoneal administration to rats. Consistent with prostaglandin synthetase inhibition, 7e prevented arachidonic acid induced diarrhea in mice and also collagen, ADP, or epinephrine induced platelet aggregation in human platelet-rich plasma. In contrast to many prostaglandin synthetase and platelet-aggregation inhibitors, 7e had neither ulcerogenicity nor systemic antiinflammatory activity in rats.
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D003967:Diarrhea / Q000139:chemically induced; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D010974:Platelet Aggregation / Q000187:drug effects*; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D051381:Rats
chemical_list: D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D009570:Nitriles; D011460:Prostaglandins F; D001241:Aspirin; D007213:Indomethacin