title: Yolk sac tumor of the anterior mediastinum. Case report with light- and electron-microscopic examination and immunohistochemical study of alpha-fetoprotein.
abstract: A case of yolk sac tumor of the anterior mediastinum was studied by light and electron microscopy and found to have characteristic patterns which were similar to a neoplasm of gonadal origin. These findings, in addition to the immunohistochemical identification of alpha-fetoprotein in the tumor, indicated that the neoplasm was germ cell in origin. A brief review of previously reported cases is included. Prognosis of the patients with yolk sac tumor of the anterior mediastinum was generally dismal; however, those patients with tumors incidentally found but completely excised survived without evidence of reucrrence.
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D008649:Mesonephroma / Q000032:analysis / Q000648:ultrastructure*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins