The effect of ethanol on the metabolism of chronically-administered l-alpha-acetylmethadol (LAAM) in the rhesus monkey.
The metabolism of 3H-LAAM was studied in monkeys treated acutely and chronically with 2 mg/kg LAAM via intragastric catheter three times weekly. From the 15th week, 250 mg/kg ethanol every 2 hours (3g/kg/day) was also administered. This dose of ethanol did not impair the metabolism of LAAM in monkeys.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D000882:Haplorhini; D008253:Macaca mulatta; D008691:Methadone / Q000031:analogs & derivatives*; D008692:Methadyl Acetate / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D000431:Ethanol; D008692:Methadyl Acetate; D008691:Methadone