The fine specificity of regulatory T cells. IV. Idiotypic complementarity and antigen-bridging interactions in the anti-lysozyme response.
The hen egg-white lysozyme (HEL)-specific B cells which are activated in response to HEL share a cross-reactive idiotype as well as submolecular specificity. Helper T cells of two different specificities are implicated in their optimal activation, one recognizing the idiotype and the other, an epitope on the HEL molecule opposite to the one recognized by B cells. Thus, efficient T-B collaboration involves both idiotypic complementary and antigen bridging.
D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002450:Cell Communication; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007130:Immunoglobulin Idiotypes; D051379:Mice; D008805:Mice, Inbred A; D009113:Muramidase / Q000276:immunology*; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D009113:Muramidase