Treatment of Prinzmetal's angina due to coronary artery spasm using verapamil: a report of three cases.
In 3 patients with Prinzmetal's variant angina there were inferior epicardial injury patterns on the electrocardiogram, corresponding to right coronary artery narrowing. Attacks were provoked by beta-adrenergic blockade and stopped by nitroglycerine and atropine. Spasm of the right coronary artery was demonstrated in the 2 patients who had high parasympathetic activity. In all 3 cases attacks disappeared on verapamil. We suggest that calcium-antagonists, which dilate the coronary arteries, should be used in the treatment of Prinzmetal's angina pectoris rather than beta-adrenergic blockers, which do not have this property.
D000787:Angina Pectoris / Q000188:drug therapy*; D000788:Angina Pectoris, Variant / Q000188:drug therapy* / Q000209:etiology; D001285:Atropine / Q000627:therapeutic use; D003327:Coronary Disease / Q000150:complications; D004562:Electrocardiography; D006327:Heart Block / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D013035:Spasm / Q000150:complications; D014700:Verapamil / Q000627:therapeutic use*
D001285:Atropine; D014700:Verapamil; D005996:Nitroglycerin