Pulmonary carcinoid tumours: a comparative regional study.
Twenty-two pulmonary carcinoid tumours (18 central, 4 peripheral) were seen in this department over an 11-year period. The majority of the tumours displayed a mixed pattern on microscopic examination, and cell-nest formation was a prominent feature in sixteen. The findings are at variance with the results of a similar series reported from Japan and suggest that there is regional variation in the tumour pattern of pulmonary carcinoids. Various aspects of the histopathology are discussed, and a causal relationship between ossification of bronchial cartilage in these tumours and locally produced calcitonin is postulated.
D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000453:epidemiology / Q000473:pathology* / Q000648:ultrastructure; D004739:England; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007494:Ireland; D008175:Lung Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013194:Staining and Labeling; D014481:United States