Studies of vasospasm. II. The use of nitroglycerin cigarettes.
It was discovered that smoking a cigarette containing nitroglycerin produced identical action on the peripheral pulses and relieved angina pectoris in the same way as sublingual administration. A group of 73 patients with various vascular conditions was subjected to 121 acute tests using a cigarette containing 0.0012 Gm (1/50th grain) nitroglycerin. Thirteen patients smoked cigarettes containing 0.0004 Gm (1/150th grain) nitroglycerin six to 20 times daily for periods up to two years. This method of using the drug assures frequent application of small doses and gives a nearly continuous nitroglycerin effect.
D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000494:pharmacology; D012907:Smoking / Q000150:complications / Q000503:physiopathology*; D014652:Vascular Diseases / Q000209:etiology / Q000503:physiopathology*
D005996:Nitroglycerin