title: [Role of vitamin B 12 in the incorporation of ribonucleosides into the DNA of various Periplaneta americana cell lines].
abstract: Hemocytes and non hemocytes in vitro cell lines from Periplaneta americana, have been tested for their ability to incorporate, in the presence of vitamin B 12, various nucleic acid precursors into their DNA. Evidence was shown for enhanced transformation of all ribonucleotides into deoxyribonucleotides in the presence of vitamin B 12. Moreover, in hemocyte cell lines, it was demonstrated that vitamin B 12 produced an activation of thymidine kinase activity.
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D003058:Cockroaches / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D009705:Nucleosides / Q000378:metabolism*; D009711:Nucleotides / Q000096:biosynthesis; D010526:Periplaneta / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D013937:Thymidine Kinase / Q000378:metabolism; D014529:Uridine / Q000378:metabolism; D014805:Vitamin B 12 / Q000502:physiology*
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D004247:DNA; D013937:Thymidine Kinase; D000241:Adenosine; D014805:Vitamin B 12; D013936:Thymidine; D014529:Uridine
vernacular_title: Rôle de la vitamine B 12 dans l'incorporation de ribonucléosides dans l'ADN de diverses lignées cellulaires de Periplaneta americana.