Effect of nutritional status and 5-fluorouracil on protein synthesis in parenterally alimented LEW/Mai rats.
LEW/Mal rats bearing transplantable adenocarcinomas were maintained parenterally for 4 days on 1) a regimen adequate in amino acids and glucose and 2) severely hypocaloric glucose. Rats from both groups were given 17.5 mg 5-fluorouracil (FUra)/kg/day as a continuous infusion for 3 days. Cumulative nitrogen balance, fractional tissue protein synthesis rates, and liver and muscle distribution of FUra and its metabolites were determined. Results were compared to those found with a series of control rats that were not treated with FUra. No changes attributable to FUra were found in the starved rats (1.25 g glucose/day). In the fed rats (15 g glucose plus 2.5 g amino acids/day), FUra decreased the liver and diaphragm fractional protein synthesis rates and the nitrogen retention.
D000230:Adenocarcinoma / Q000628:therapy; D000818:Animals; D005472:Fluorouracil / Q000378:metabolism / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy*; D009747:Nutritional Physiological Phenomena; D010289:Parenteral Nutrition, Total; D051381:Rats; D011917:Rats, Inbred Lew
D009363:Neoplasm Proteins; D005472:Fluorouracil