Effect of dihydroergocristine infusion on tolbutamide-induced insulin secretion in man.
The insulinemic response to 1 g of tolbutamide i.v. is greatly enhanced (+ 145%) after a 60-min infusion of the alpha-lytic dihydrogenated ergot alkaloid, dihydroergocristine (83.3 micrograms/min, corresponding to a total dose of 5 mg) in 7 healthy subjects. No differences are observed in the glycemic responses.
D000328:Adult; D004088:Dihydroergotoxine; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D008297:Male; D014044:Tolbutamide
D007328:Insulin; D004088:Dihydroergotoxine; D014044:Tolbutamide