[Induction of hepatic microsomal enzymes in chickens effected by various persistent foreign materials].
Changes in the levels of microsomal proteins, in the activity of microsomal aniline hydroxylase, and in the effectivity of Thiopental were studied in chickens given the Czechoslovak-produced type of polychlorinated biphenyls - Delor 103. The increased activity of aniline hydroxylase and the decrease of Thiopental sleeping time in chickens exposed to the action of Delor 103 indicate that this preparation is able to induce liver microsomal enzymes in doses as low as 5 mg per kg of feed. The induction of liver microsomal enzymes appears to be an important factor, able to exercise a direct influence on the biotransformation of various biologically important substances in the organism of chickens.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D002645:Chickens; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology
D011078:Polychlorinated Biphenyls; D000815:Aniline Hydroxylase; D013874:Thiopental
Indukcia mikrozomálnych enzýmov pecene kurciat úcinkom niektorých perzistentných cudzorodých látok.