title: The pathogenesis of osteoarthrosis.
abstract: Recent investigations on protease inhibitors in articular cartilage have provided new insights into the possible initial lesions of osteoarthrosis. A hypothesis has been formulated based upon an impaired ability of chondrocytes to synthesize protease inhibitors, which leads to loss of matrix integrity and vascular invasion from subchondral bone and the joint margins.
mesh_terms: D002358:Cartilage, Articular / Q000201:enzymology / Q000503:physiopathology*; D006801:Humans; D009389:Neovascularization, Pathologic; D010003:Osteoarthritis / Q000209:etiology*; D011480:Protease Inhibitors / Q000096:biosynthesis*
chemical_list: D011480:Protease Inhibitors