Immunological cross-reactivities of sulfocephalosporins.
The immunological cross-reaction among sulfocephalosporins (cefsulodin, SFC-I, SFC-II), cephaloridine, sulbenicillin, penicillin G and 7-aminocephalosporanic acid has been investigated. A specific antibody was produced in rabbits against several structurally related haptens. The sensitization was conducted with a hapten-human serum albumin conjugate, which was prepared in an alkaline solution, with Freund's complete adjuvant. A cross-reaction was claraly demonstrated between sulfocephalosporins and sulbenicillin, but not between sulfocephalosporins and cephaloridine, penicillin G or 7-aminocephalosporanic acid.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002511:Cephalosporins / Q000276:immunology*; D003429:Cross Reactions; D006168:Guinea Pigs; D006241:Haptens / Q000276:immunology; D005779:Immunodiffusion; D010323:Passive Cutaneous Anaphylaxis; D011233:Precipitin Tests; D011817:Rabbits
D002511:Cephalosporins; D006241:Haptens