title: [Severe pulmonary embolism and recurrent thrombophlebitis caused by hereditary antithrombin III deficiency].
abstract: Severe pulmonary embolism with thrombosis of the inferior vena cava was observed in a 16 year old girl with no risk factors and treated successfully by fibrinolytic therapy. Secondarily, despite heparino-therapy, upper limb venous thrombosis occurred. Investigation of the clotting factors in the patient and her family revealed a hereditary deficit of antithrombin III. The features of the haemotological diagnosis of this rare condition and the therapeutic implications are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000990:Antithrombin III; D005260:Female; D006487:Hemostasis; D006801:Humans; D010375:Pedigree; D011655:Pulmonary Embolism / Q000209:etiology*; D013924:Thrombophlebitis / Q000209:etiology / Q000235:genetics*; D014682:Vena Cava, Inferior
chemical_list: D000990:Antithrombin III
vernacular_title: Embolie pulmonaire sévère et thrombophlébite récidivante en rapport avec un déficit héréditaire en antithrombine III.