[Effect of cell proliferation on the condensation of the X chromosome in culture medium of the individual karyotype 49 XXXXX].
The influence of cell proliferation on the condensation of the X chromosome was observed in vitro in human fibroblasts with 49 XXXXX karyotype. The frequency of cells with four Barr-bodies is low during the logarithmic growth phase and increases to 80% when the cells are becoming confluent or, independently of cell contact, when cell growth is arrested in a medium with low serum content. The condensation of th X chromosomes is reversible when the cells start growing again in medium with a higher serum content.
D002455:Cell Division; D002478:Cells, Cultured; D002875:Chromosomes / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D007621:Karyotyping; D012729:Sex Chromosome Aberrations / Q000503:physiopathology
L'influence de la prolifération cellulaire sur la condensation du chromosome X en culture des individus à caryotype 49 XXXXX.