[Short-term effects of gamma-globulins on sleep organization in epileptic patients (author's transl)].
A study of the effect of gamma-globulins on sleep was conducted in 8 patients aged 1 to 35 years with epilepsy not responding to any of the conventional treatments. Two polygraphic recordings were carried out during the 4th and 5th nights following a placebo injection and then an injection of gamma-globulin 16 Merieux (1 ml/kg). The short-term effects of the gamma-globulins were : --reduction in percentage of paroxysms, --an acceleration in the electroencephalographic tracings of the different stages of sleep and those of the waking period, --a statistically significant increase in the percentage of paradoxical sleep, though the general organization of sleep remained unchanged.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D005719:gamma-Globulins / Q000627:therapeutic use*
D005719:gamma-Globulins
Effets à court terme des gamma-globulines sur l'organisation du sommeil chez des malades êpileptiques.