Effects of 5-hydroxytryptophan, oxotermorine, and tetrahydroaminoacridine on apomorphine-induced stereotypy.
The stereotyped behavior induced by apomorphine in rats was inhibited by oxotremorine and tetrahydroaminoacridine (THA). 5-Hydroxytryptophan (5-HTP) did not change stereotypy scores. These data show influence of cholinergic mechanisms on such behavior. Possible clinical applications are discussed.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D006801:Humans; D008297:Male; D010095:Oxotremorine / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013619:Tacrine / Q000494:pharmacology*; D013997:Time Factors
D000166:Acridines; D013619:Tacrine; D010095:Oxotremorine; D006916:5-Hydroxytryptophan; D001058:Apomorphine