title: Depression of protective mechanisms against microörganisms in tumor-bearing mice and its restoration by adjuvants.
abstract: Bacterial growth within 72 hr after an intravenous inoculation with Listeria monocytogenes was enhanced strikingly in the liver of mice, when viable cells of sarcoma-180 were injected subcutaneously into ddN, C3H/He, and BALB/c mice 5 hr before the inoculation. Such an enhanced bacterial growth appears to be attributable to a depressed ability of macrophages to digest engulfed bacteria. Pretreatments with zymosan, killed BCG, or viable BCG prevented such depression in tumor-bearing mice and increased the bactericidal activity in the liver of normal and tumor-bearing mice above the level of non-treated normal mice. Such adjuvants may be useful not only for augmentation of antitumor activity but also for augmentation of antimicrobial activity in tumor-bearing hosts.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D001500:BCG Vaccine; D001419:Bacteria / Q000276:immunology*; D002464:Cell Migration Inhibition; D005260:Female; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology; D008099:Liver / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D012510:Sarcoma 180 / Q000276:immunology*; D015054:Zymosan / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D015054:Zymosan