[Transforming activity and the oncogenicity of simian adenovirus SA7 DNA].
The transforming and oncogenous activity of uncleaved DNA of simian adenovirus SA7 (AdSA7) and the products of its restriction by endonucleases R. Bam HI and R. SalI was studied. It was shown that uncleaved virus DNA transformed the rat kidney cells and rat embryo fibroblasts and induced tumors in newborn hamsters. AdSA7 DNA, hydrolysed by R. Bam HI, posessed the transforming activity. The mixture of DNA fragments, obtained after hydrolysis by R. SalI was oncogenous in hamsters.
D000256:Adenoviridae / Q000472:pathogenicity*; D000261:Adenoviruses, Simian / Q000472:pathogenicity*; D000818:Animals; D002472:Cell Transformation, Viral / Q000187:drug effects*; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral; D004262:DNA Restriction Enzymes / Q000494:pharmacology; D004279:DNA, Viral / Q000494:pharmacology*; D000882:Haplorhini; D006868:Hydrolysis; D009374:Neoplasms, Experimental / Q000209:etiology*; D051381:Rats; D013997:Time Factors; D014776:Virus Cultivation
D004279:DNA, Viral; D004262:DNA Restriction Enzymes
Transformiruiushchaia aktivnost' i onkogennost' DNK adenovirusa obez'ian SA7.