title: Immunochemical comparisons among myelin basic proteins.
abstract: 1. The relationships among myelin encephalitogenic or basic proteins were immunochemically examined. 2. Rabbit antisera to myelin basic proteins isolated from chicken, rabbit, bovine, guinea-pig, and human brain specimens were prepared. By quantitative microcomplement fixation these rabbit antisera were used to measure cross-reactions among the myelin basic proteins of the turtle, chicken, rat, rabbit, cow, pig, sheep, dog, guinea-pig, monkey and human. 3. A spectrum of cross-reactivities was detected even though some cross-reactivity persisted across major phylogenetic barriers. Varying, but sometimes marked, differences existed in reactivities of the small and large basic proteins of the rat. Reciprocity of cross-reactivities among basic proteins was inconstant. 4. This study demonstrates the range of immunochemical cross-reactivities among myelin basic proteins and the sensitivity of quantitative microcomplement fixation in assessing such antigenic or conformational differences.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002645:Chickens; D004285:Dogs; D000939:Epitopes / Q000032:analysis*; D006168:Guinea Pigs; D006801:Humans; D008253:Macaca mulatta; D004676:Myelin Basic Protein / Q000276:immunology / Q000302:isolation & purification*; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D014426:Turtles
chemical_list: D000939:Epitopes; D004676:Myelin Basic Protein