Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia.
A chromosomal anomaly, 21q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicators are found in platelet homogenates of thrombocythemic patients. Evidence is presented from 2 laboratories (Philadelphia, USA and Bologna, Italy) for the 21q- deletion in MPD patients. Thirty patients evaluated for the presence of both viral and chromosomal markers in Philadelphia showed positive correlations.
D000818:Animals; D001792:Blood Platelets / Q000032:analysis; D002872:Chromosome Deletion; D002904:Chromosomes, Human, 21-22 and Y; D005819:Genetic Markers; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000032:analysis*; D007951:Leukemia, Myeloid / Q000209:etiology; D009196:Myeloproliferative Disorders / Q000209:etiology*; D011087:Polycythemia Vera / Q000209:etiology; D012194:RNA-Directed DNA Polymerase / Q000097:blood; D012190:Retroviridae; D013922:Thrombocytosis / Q000209:etiology; D014412:Tumor Virus Infections / Q000175:diagnosis
D005819:Genetic Markers; D012194:RNA-Directed DNA Polymerase