Acute eosinophilic leukemia. An ultrastructural study.
Observations on a 32 year old male are described. Hematological examination demonstrated leukocytosis with circulating blastosis and dystrophic hypereosinophilia of the blood and bone marrow, with cells at various stages of maturation. Cytotoxic chemotherapy led to complete remission for 5 months followed by a terminal relapse. No features in favor of an "eosinophilic collagenosis" were revealed at autopsy. Repetitive ultrastructural studies performed during evolution of the illness demonstrated considerable anomalies of the eosinophil line. The present observation thus shows the clinical, evolutional, cytological and autopsy criteria of an acute eosinophilic leukemia.
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D004804:Eosinophils / Q000648:ultrastructure*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000648:ultrastructure*; D015470:Leukemia, Myeloid, Acute / Q000648:ultrastructure; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012008:Recurrence
D003561:Cytarabine; D011241:Prednisone; D003630:Daunorubicin