[Increased demethylation of aminopyrine under long-term treatment with anticonvulsive drugs (author's transl)].
Demethylation of aminopyrine was measured in 25 healthy controls and 19 epileptics on long-term treatment with anticonvulsants by the 14C-aminopyrine breath test. Compared to controls epileptics exhibited increased cumulative 14CO2-exhalation rates (88.7% at 30 min, 62.6% at 2 h and 24.8% at 8h) following ingestion of 2 mu Ci 14C-aminopyrine. The results suggest that long-term treatment with antiepileptic drugs results in increased demethylating function of the liver which can be easily detected by a simple breath analysis technique like decreased demethylation in chronic liver disease.
D000632:Aminopyrine / Q000378:metabolism*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001944:Breath Tests; D002118:Calcium / Q000378:metabolism; D002250:Carbon Radioisotopes; D002908:Chronic Disease; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000175:diagnosis; D008111:Liver Function Tests; D008134:Long-Term Care
D000927:Anticonvulsants; D002250:Carbon Radioisotopes; D000632:Aminopyrine; D002118:Calcium
Gesteigerte Demethylierung von Aminophenazon unter antikonvulsiver Langzeitbehandlung.