Hereditary aspects of duodenal ulceration: pepsin 1 secretion in relation to ABO blood groups and ABH secretor status.
Pepsin 1, the ulcer-associated pepsin, occurred significantly more frequently in the gastric juice of those patients with duodenal ulcer who did not secrete A, B, or H antigens into gastric juice than in those secreting these antigens. This observation may explain the increased proportion of such non-secretors among patients with duodenal ulceration. In patients with gastric ulcer and non-ulcer dyspepsia, and in a miscellaneous group of patients, there was no association of pepsin 1 secretion with secretor status, suggesting that the association noted in duodenal ulceration is an indirect rather than a direct one. No increase of pepsin 1 occurred in group O patients with peptic ulcer, so that the increased proportion of such patients in peptic ulcer does not arise from differences in pepsin 1 secretion.
D000017:ABO Blood-Group System / Q000235:genetics*; D004381:Duodenal Ulcer / Q000235:genetics* / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D010434:Pepsin A / Q000378:metabolism*; D010641:Phenotype; D012463:Saliva / Q000378:metabolism; D013276:Stomach Ulcer / Q000235:genetics* / Q000378:metabolism
D000017:ABO Blood-Group System; D010434:Pepsin A