[The value of potassium phosphate supplements in the treatment of diabetic ketoacidosis. Effects upon 2.3-diphosphoglycerate and tissue oxygenation (author's transl)].
Amongst 8 diabetics with severe ketoacidosis and treated identically, 4 received intravenous supplements of potassium phosphate (25 mmol PO4/I) for 24 hours. This resulted in blood 2.3-diphosphoglycerate and in vivo P50 levels which were invariably higher than in the control subjects and a fall in lactate/pyruvate ratio. These results reflect improved tissue oxygenation.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000188:drug therapy* / Q000378:metabolism; D004163:Diphosphoglyceric Acids / Q000097:blood; D006801:Humans; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D004163:Diphosphoglyceric Acids; D011188:Potassium
Traitement de la céto-acidose diabétique: intérêt d'un supplément de phosphate de potassium. Effet sur le 2,3-diphosphoglycérate et l'oxygénation tissulaire.