Cytotoxic and agglutinating H-Y antibodies in multiparous female mice.
Pregnancy in inbred mice is associated with long-term accceptance of H-Y-incompatible skin grafts (in some "rejector" strain females) and with the formation of cytotoxic and agglutinating H-Y antibodies (in females generally). Yet there is no evident correlation between the two phenomena; postpartum females of nonrejector (H-2k), intermediate rejector (H-2d), and rejector (H-2b) strains all may produce H-Y antibodies, and postpartum H-2b females bearing H-Y-incompatible male skin grafts of long-standing may or may not produce H-Y antibodies depending on the individual recipient. Thus, it remains to be seen whether the presence of H-Y antibodies, as detectable to our sperm cytotoxicity and Protein A-SRBC agglutaination tests, signifies a corresponding presence of enhancing H-Y antibodies in pregnant females, and indeed whether enhancement (with respect to H-Y antigen) may play any part in the survival of the inbred male fetus.
D000372:Agglutination Tests; D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D003602:Cytotoxicity, Immunologic; D005260:Female; D005802:Genes, MHC Class II; D006084:Graft Rejection; D006085:Graft Survival; D006649:Histocompatibility Antigens / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D016038:Skin Transplantation
D000906:Antibodies; D006649:Histocompatibility Antigens