[Dose distribution of bone-seeking radiopharmaceuticals in the rat (author's transl)].
The biokinetics of 32P-P, 32P-PPi, 85Sr, 99mTc- and 113Sn-EHDP were evaluated in the young rat. The dose distribution of the beta-emitters 32P, 89Sr, 121Sn and 188Re was calculated from the measured biological half-lifes. The highest dose to soft tissues and therefore also to bone-marrow in relation to the bone dosis was found for 32P-P. The lowest dose was found for 89Sr. Favourable results were obtained in the diphosphonate compounds. The use of 32P-PPi instead of 32P-P appears to be advantageous, too. The dose relation between normal bone and the growth plate of the femur was significantly lower for 89Sr than for the other radiopharmaceuticals.
D000818:Animals; D012968:Etidronic Acid / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D051381:Rats; D013326:Strontium Radioisotopes; D013667:Technetium; D014001:Tin
D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D013667:Technetium; D014001:Tin; D012968:Etidronic Acid
Dosisverteilung osteotroper Radiopharmaka in der Ratte.