Anti-D immunoglobulin preparations: the stability of anti-D concentrations and the error of the assay of anti-D.
An analysis of the assay of 28 preparations of anti-D immunoglobulin using a radioisotope method carried out at 6-montly intervals for 2--4.5 years showed an average fall in anti-D concentration of 10.6% each year, with 99% confidence limits of 6.8--14.7%. The fall in anti-D concentration after storage at 37 degrees C for 1 month was less than 8%, the minimum change that could be detected. No significant change in physical characteristics of the immunoglobulin were detected. The error of a single estimate of anti-D by the radioisotope method (125I-labelled anti-IgG) used here was calculated to be such that the true value probably (p = 0.95) lay between 66 and 150% of the estimated value.
D000888:Antibodies, Anti-Idiotypic; D003080:Cold Temperature; D004355:Drug Stability; D006358:Hot Temperature; D006801:Humans; D007074:Immunoglobulin G; D011309:Preservation, Biological; D012204:Rh-Hr Blood-Group System; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D012204:Rh-Hr Blood-Group System