Use of specific antisera against leukemia-associated antigens in the diagnosis of childhood acute lymphoblastic leukemia.
A series of 66 children with acute lymphoblastic leukemia (ALL) at diagnosis were investigated (simultaneously) for various surface markers. For this purpose the reaction of specific antisera against ALL antigens and T cell antigens was analysed in every case by several test systems, namely immunofluorescence, microcytotoxicity and complement fixation. A clearly defined classification in 6 subgroups of ALL emerged. The clinical data at presentation and possible correlations with the immunological subgroups were demonstrated.
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007106:Immune Sera; D011947:Receptors, Antigen, B-Cell