The action of DL-2,4-diaminobutyric acid on the cataleptogenic effects of pilocarpine and alpha-flupenthixol in rats.
The existence of a strionigral GABA-ergic pathway having an inhibitory effect on the nigrostriatal dopaminergic system has been proposed. The work reported in this paper was undertaken to investigate whether modification of the GABA-eric system by the GABA neuronal uptake inhibitor DL-2,4-diaminobutyric acid (DABA) would affect cholinergic (pilocarpine) and/or neuroleptic alpha-flupenthixol (alpha-FPT) induced catalepsy. DABA pretreatment was shown to enhance significantly both alpha-FPT and pilocarpine induced catalepsy. DABA alone had no cataleptic activity. The results are interpreted as supporting the existence of an inhibitory strionigral GABA-ergic pathway.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D004357:Drug Synergism; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology*; D006801:Humans; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D013892:Thioxanthenes / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000613:Aminobutyrates; D013892:Thioxanthenes; D010862:Pilocarpine; D005680:gamma-Aminobutyric Acid; D005475:Flupenthixol