title: Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells.
abstract: The ability of NP-coupled syngeneic spleen cells to induce antigen-specific T-suppressor cells capable of binding to NP-BSA-coated Petri dishes and mediating transfer of specific suppressive activity to NP was demonstrated. Furthermore, in strains of mice bearing the Ig-1b allotype, including SJL, and in (non-Ig-1b x Ig-1b)F1 hybrids, the NP-specific suppressor cells also interferes with expression of immunity after priming with NIP-BGG. Anti-NPb anti-idiotype antiserum plus complement treatment effectively abrogated the ability to transfer suppression. Formal genetic mapping of the fine specificity of cross-reactivity with Ig-1 allotypic congenic mice implies that expression of this trait is linked to the Ig-1b heavy chain linkage group. The sensitivity of NP-suppressor cells of appropriate strains to anti-idiotype treatment was also consistent with the formal mapping data. These experiments suggest that there are shared V-region structures on antibody and T cells that are crucial in the suppression pathway for the same antigen.
mesh_terms: D000818:Animals; D000939:Epitopes; D006241:Haptens / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D009596:Nitrophenols / Q000276:immunology*; D010648:Phenylacetates; D011948:Receptors, Antigen, T-Cell; D012710:Serum Albumin, Bovine / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
chemical_list: D000939:Epitopes; D006241:Haptens; D007143:Immunoglobulin Heavy Chains; D009596:Nitrophenols; D010648:Phenylacetates; D011948:Receptors, Antigen, T-Cell; D005719:gamma-Globulins; C026242:4-hydroxy-5-nitrophenyl acetic acid; D012710:Serum Albumin, Bovine