Decreased smooth muscle side effects with 16, 16-dimethyl-trans-delta2-PGE1 methyl ester in Japanese monkey (Macaca Fuscata Fuscata).
The smooth muscle stimulating activity of a new PGE1 analog, 16, 16-dimethyl- trans delta2 -PGE1 methyl ester (ONO-802) was evaluated by simultaneously recording the EMG of the uterus and intestines, along with urinary bladder pressure, and blood pressure in pregnant and non-pregnant Japanese monkeys (Macaca fuscata fuscata). Single intravenous injections of ONO-802 in increasing dosages (0.2-5 microgram/kg) were found to be 50-100 times or more effective in inducing uterine contraction than PGF2alpha and PGE1. A mild, transient gastrointestinal muscle stimulating activity was observed, but change in urinary bladder pressure and blood pressure was not evident. ONO-802 induced uterine contractions in the pregnant animals were 10 times greater than in the non-pregnant animals. These results suggest that ONO-802 may be a suitable clinical prostaglandin for use in therapeutic abortion.
D000028:Abortion, Induced; D000818:Animals; D001795:Blood Pressure Determination; D004353:Drug Evaluation, Preclinical; D005260:Female; D000882:Haplorhini; D007422:Intestines / Q000187:drug effects*; D008251:Macaca; D009130:Muscle, Smooth / Q000187:drug effects*; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects*
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic