Protection by 4-amino-hex-5-enoic acid (gamma-vinyl GABA) and hypobaric hypoxia against kainic acid neurotoxicity.
The behavioral effects following IP injection of kainic acid in rats could be cancelled with hypobaric hypoxia (8% O2 corresponding to 7000 m altitude) or with IP injections of 7-amino-hex-5-enoic acid at a dose of 0.9 g/kg-1. This protection may result from increased accumulations of GABA in brain tissues.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D001274:Atmospheric Pressure; D001522:Behavior, Animal / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D010100:Oxygen / Q000494:pharmacology*; D011759:Pyrrolidines / Q000037:antagonists & inhibitors*; D051381:Rats; D013997:Time Factors; D000637:Transaminases / Q000037:antagonists & inhibitors*; D020888:Vigabatrin
D000614:Aminocaproates; D011759:Pyrrolidines; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin; D010100:Oxygen; D007608:Kainic Acid