Thyrotrophin-releasing hormone inhibits the pentagastrin stimulated gastric secretion in man. A dose response study.
Actions of thyrotrophin-releasing hormone (TRH) have generally been confined to the central nervous system (CNS). We have studied the effect of increasing doses of TRH i.v. (8, 40, 200 and 1000 microgram/h) on pentagastrin-stimulated gastric secretion in ten normal individuals. All doses caused stepwise inhibition of gastric juice (volume), acid and pepsin output. When employing the largest dose of i.v. TRH (1000 microgram/h) the inhibition was 44% for gastric volume, 51% for acid output and 57% for pepsin output. This study shows that TRH inhibits gastric secretion, and indicates that TRH has actions outside the CNS in man.
D000328:Adult; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D013270:Stomach / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D010434:Pepsin A; D010418:Pentagastrin