title: Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the white gene position effect variegation in Drosophila melanogaster.
abstract: The deficiency of the 38B-40 region containing histone genes in one of the 2nd chromosomes of D. melanogaster triploid intersexes increases the template activity of X-chromosomes both in vivo and in vitro without noticeably affecting autosome activity. This deficiency in the heterozygous state inhibits the variegated position effect of the white gene in the T(1;3)Wvco translocation in diploid females and males, but not affect their rate of development. The variegation suppressor Su(var)hg-1 not only suppress the gene position effect in diploid flies, but also increases the template activity of X-chromosomes in triploid intersexes. The results are discussed with respect to the dependence of gene activity on the structure of chromosomes (density of DNP packing).
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005796:Genes; D006657:Histones / Q000235:genetics*; D009154:Mutation; D011003:Ploidies; D014158:Transcription, Genetic; D014960:X Chromosome
chemical_list: D006657:Histones