Hypnotic susceptibility to various depressants in rats selected for differential ethanol sensitivity.
MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting reflex following a hypnotic dose of ethanol was replicated. The results are discussed in terms of a phenotypic difference in central nervous systems sensitivity to a range of sedative-hypnotics.
D000818:Animals; D002697:Chloral Hydrate / Q000008:administration & dosage / Q000494:pharmacology*; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005824:Genetics, Behavioral; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D010641:Phenotype; D051381:Rats; D012890:Sleep / Q000187:drug effects*
D000431:Ethanol; D002697:Chloral Hydrate; D010634:Phenobarbital