Macromolecular binding in assessing drug and chemical-induced tissue lesions.
The general concepts that underlie the use of macromolecular binding in studies of chemical-induced tissue lesions are reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is presented.
D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D002509:Cephaloridine / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D004247:DNA / Q000378:metabolism*; D005663:Furans / Q000633:toxicity; D006834:Hydrazines / Q000494:pharmacology; D011485:Protein Binding; D012313:RNA / Q000378:metabolism*; D013876:Thiophenes / Q000633:toxicity; D014116:Toxicology
D005663:Furans; D006834:Hydrazines; D013876:Thiophenes; D000082:Acetaminophen; D012313:RNA; D004247:DNA; D002509:Cephaloridine