Polychlorinated biphenyls induced rat liver adenomas.
Multiple liver adenomas were found in 30 month old female rats which had received for 28 months, 200 ppm polychlorinated biphenyls (Arochlor 1254) in their drinking water. No lung metastases were detected. The examination of fragments of these adenomas under the electron microscope showed group polymorphism of the hyperplastic liver cells. The ultrastructural changes were considered to be as a result of chemical lesions induced by polychlorinated biphenyls and as adaptive morphological responses to the long term exposure to toxic chemical compounds. The group polymorphism was seen in the light of the clonal theory, to be the result of inherited biochemical lesions occurring in cells of hyperplastic liver nodules.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D005260:Female; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats
D011078:Polychlorinated Biphenyls