title: Schistosoma mansoni in the Kenyan baboon (Papio anubis): the development and predictability of resistance to homologous challenge.
abstract: Groups of baboons were exposed to primary infections of either 500 or 2,000 Schistosoma mansoni cercariae per baboon (c.p.b.). Five from each infection level and five uninfected baboons were challenged with 2,500 c.p.b. at one of four intervals of time after primary infection and killed ten weeks later, together with unchallenged appropriate primary infection controls. Primary faecal egg excretion was related to the cercarial dose, showing some systematic fluctuations during the 78 weeks of the experiment. Challenge infections increased faecal egg excretion in certain cases only. Faecal and tissue egg production were usually suppressed in the challenge worms. In contrast to less heavily infected, challenge-control baboons bearing primary infections, the challenged baboons had minimal gross pathology and there were no deaths due to acute schistosomiasis from the challenge infection. Over-all resistance to reinfection was low and unrelated to the age or intensity of the primary infections. However, seven baboons yielded less than 50% of the expected challenge worms. An in vitro assay, measuring anti-schistosomula antibody and peripheral leucocyte cytotoxic activity, successfully identified the in vivo immune status at thetime of challenge of 14/18 baboons tested. The in vivo significance of the immunological mechanism upon which the test is based is discussed in relation to possible future baboon and human studies.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D000920:Antibody-Dependent Cell Cytotoxicity; D005243:Feces / Q000469:parasitology; D000882:Haplorhini; D010215:Papio; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology* / Q000469:parasitology; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000906:Antibodies