[Elaboration of an in vivo model, in half life size, for aeronautical purposes].
Toxic effects of combustion products originating from plane cabin constituents are studied, in vivo, in Rats. The model associates an important combustion room, and an experience room containing eight revolving cages for Rats; these cages allow a remote control of the movements of the Rats which can be electrically stimulated and ejected. Such a device permits to study the incapacitance, i.e. the inability to move. For the combustion of a seat, without ventilation, incapacitation appears in 2 to 6 min. Biochemical screening demonstrates on increase of pCO2, carboxyhemoglobin and glycemia and a decrease of pO2.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002263:Carboxyhemoglobin / Q000032:analysis; D005390:Fires; D005740:Gases / Q000633:toxicity*; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D051381:Rats; D012149:Restraint, Physical; D013026:Space Flight
D005740:Gases; D002245:Carbon Dioxide; D002263:Carboxyhemoglobin; D010100:Oxygen
Mise au point d'un modéle d'étude, in vivo, en semi-vraie grandeur dans le domaine aéronautique.