[Antialdosterones and enzymes of the adrenal gland].
With subcellular fractions of animal adrenals, the authors have looked for the effect of antialdosterones on different aspects of adrenal metabolism (steroidogenesis, some enzymes of intermediary metabolism, mitochondrial respiration). Antialdosterones act on mitochondrial respiration by inducing an uncoupling effect. Nature of this uncoupling cannot yet by precised. Antialdosterones inhibit steroidogenesis with concentrations corresponding to blood concentrations observed during treatment with these compounds. This inhibition could explain the annulation of hyperaldosteronism secondary to sodium loss and kaliemic replenishment. This enhance the interest of antialdosterones over other diuretics.
D000305:Adrenal Cortex Hormones / Q000096:biosynthesis; D000311:Adrenal Glands / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D002192:Canrenone / Q000494:pharmacology; D004372:Ducks; D006801:Humans; D006900:Hydroxylation; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D008928:Mitochondria / Q000201:enzymology; D013148:Spironolactone / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D002192:Canrenone
Antialdostérones et enzymes de la surrénale.