title: Dual-demand pacing for refractory atrioventricular re-entry tachycardia.
abstract: An automatic dual-demand pacemaker has been used in six patients to treat refractory attacks of paroxysmal re-entry atrioventricular tachycardia that occurred in the Wolff-Parkinson-White syndrome. The pacemaker was designed to pace at a fixed rate of 70 beats per minute when sensed heart rates were either below this rate or above 150 beats per minute; in the latter case, it would compete with the paroxysmal tachycardia and interrupt it after a short period of random scaning. The best location for the permanent pacing electrode and the feasibility of using the pacemaker were tested in each case during a detailed preliminary intracardiac electrophysiological study. The permanent pacing electrode was positioned in the coronary sinus in three patients and was attached to the epicardium of either the left or right ventricle in another three. All patients were given regular oral doses of verapamil or propranolol to enhance the effectiveness of the pacemaker system and, with the latter, to prevent pacemaker activation during sinus tachycardia. Over a follow-up period of between 11 and 47 months, the pacemaker system remained completely effective in three patients, but developed unreliable sensing in another two (one coronary sinus and one left ventricular lead). In the sixth patient the pacemaker was only effective when the rate of the tachycardia remained below 170 beats a minute, as when she was resting supine; when sitting or standing, however, her tachycardia rate considerably exceeded this value and the pacemaker was ineffective. Explantation of the pacemaker and either successful cryosurgical ablation of the accesory AV pathway or treatment with amiodarone was undertaken in the three patients in whom the pacemaker had failed.
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000187:drug effects; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011433:Propranolol / Q000627:therapeutic use; D012804:Sick Sinus Syndrome / Q000150:complications; D012850:Sinus of Valsalva / Q000503:physiopathology; D013614:Tachycardia, Paroxysmal / Q000628:therapy*; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications*
chemical_list: D011433:Propranolol; D014700:Verapamil; D000638:Amiodarone