Bone morphology in epileptics.
In 31 epileptics, most of whom had been on anticonvulsive drugs for decades, the amount of osteoid--active and inactive--and the osteoclast activity were measured in iliac crest biopsies and compared with the same variables from a control group. Although falling within normal limits, the amount of osteoid, in particular the inactive osteoid, was significantly increased in the epileptics. The osteoclast activity was also significantly increased in the epileptics.
D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000209:etiology; D001862:Bone Resorption / Q000473:pathology; D001842:Bone and Bones / Q000033:anatomy & histology*; D004827:Epilepsy / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000166:cytology; D010018:Osteomalacia / Q000473:pathology*; D010024:Osteoporosis / Q000473:pathology; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use
D010672:Phenytoin; D010634:Phenobarbital