[Inhibition by the enterotoxin of Vibrio cholerase of meiosis reinitiation of the Xenopus laevis oocyte induced in vitro by progesterone].
Progesterone reinitiates in vitro meiosis in Xenopus laevis oocytes. This action of the hormone can be abolished by the exotoxin of vibrio cholerae. The concentration of toxin which inhibits 50% of the progesterone (10 muM) action in about 2.5 pM. Binding experiments using 125I labelled toxin demonstrated the existence of high affinity binding sites (KD approximately 0.2 nM) located probably on the surface of the oocytes.
D000818:Animals; D002772:Cholera Toxin / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008540:Meiosis / Q000187:drug effects*; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D010063:Ovum / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D011955:Receptors, Drug / Q000378:metabolism; D014981:Xenopus
D011955:Receptors, Drug; D011374:Progesterone; D002772:Cholera Toxin
Inhibition par l'entéro-toxine de Vibrio cholerae de la réinitiation méiotique de l'ovocyte  de Xenopus laevis induite in vitro par la progestérone.