title: The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats.
abstract: The effects of arsenate on the levels of free amino acids in rat plasma and red blood cells have been investigated. The biggest changes occur in the branched-chain amino acids valine, isoleucine and leucine which are markedly decreased. The levels of several other amino-acids also change. The effects on the amino acids are not due to a change in the food intake caused by dosing with arsenate. This has been shown by comparing the results with those on fasting rats (40 h). Branched-chain amino acids in particular are markedly increased in plasma of fasting rats as opposed to a decrease in arsenate-treated rats.
mesh_terms: D000596:Amino Acids / Q000097:blood*; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D001149:Arsenates / Q000494:pharmacology*; D001151:Arsenic / Q000494:pharmacology*; D001224:Aspartic Acid / Q000097:blood; D001622:Betaine / Q000097:blood; D002940:Circadian Rhythm; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D005973:Glutamine / Q000097:blood; D005998:Glycine / Q000097:blood; D006909:Hydroxyproline / Q000097:blood; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008297:Male; D009952:Ornithine / Q000097:blood; D011392:Proline / Q000097:blood; D051381:Rats; D012694:Serine / Q000097:blood; D012737:Sex Factors; D013217:Starvation; D013654:Taurine / Q000097:blood; D014633:Valine / Q000097:blood
chemical_list: D000596:Amino Acids; D000613:Aminobutyrates; D001149:Arsenates; D007532:Isoleucine; D005973:Glutamine; D013654:Taurine; D001224:Aspartic Acid; D001622:Betaine; D012694:Serine; C009277:sodium arsenate; D011392:Proline; D009952:Ornithine; D007930:Leucine; D014633:Valine; D001151:Arsenic; D006909:Hydroxyproline; D005998:Glycine