title: Influence of the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride on the lifetime of Drosophila melanogaster.
abstract: A slowdown of the aging process was established in Drosophila melanogaster than received the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride. The action of the preparation in a dose of 0.01% at the larval stage of development leads to an 18--20% increase in the average lifetime of females and males and lengthens the maximum lifespan of males. The older the individuals by the beginning of the experiment, the weaker the influence of the geroprotector: The average lifetime of females taken in the experiment at one day old is increased 12%; the influence at an age greater than 20 days is ineffective.
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male; D010847:Picolines / Q000494:pharmacology*
chemical_list: D010847:Picolines