Cytogenetics of acute and chronic myelofibrosis.
In myelofibrosis, acute or chronic, as well as in other myeloproliferative disorders which carry an increased risk of developing leukemia, a clone of hemic cells with a chromosome abnormality is a relatively common occurrence. To date, however, the presence or absence of a cytogenetic alteration has not been of prognostic value with respect to subsequent clinical course. No particular karyotypic change is specific for myelofibrosis, but many of the same non-random abnormalities occur as in other leukemic and preleukemic states. Both cytogenetic and isoenzyme data indicate that the fibrous tissue in the marrow is not part of the myeloproliferative clone.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D002908:Chronic Disease; D002999:Clone Cells; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis