title: Macroglobulinemia Waldenström complicated by autoimmune hemolytic anemia, meningeal sign and femoral lysis.
abstract: A necropsied case of macroglobulinemia Waldenström with unusual complications was presented; the patient was found to have autoimmune hemolytic anemia, first. During the course of its treatment, he developed monoclonal immunoglobulin M in serum together with lytic osseous lesion in both femurs, and died of meningeal involvement by tumor cells. Clinically, he had hepatosplenomegaly and generalized lymphadenopathy. The macroglobulin was kappa type of light chain, ultracentrifugation showed sharp spike of 21S in 18.6%, and myelogram revealed increased lymphocytoid series of 29.6%. It was proved that autoantibody causing autoimmune hemolytic anemia was composed of IgG and macroglobulin itself had no activity as an anti-red cell antibody. An emphasis was made that autoimmune hemolytic anemia followed by macroglobulinemia is based on the state of immunodeficiency of this patient.
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D001862:Bone Resorption / Q000209:etiology*; D005269:Femur; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D008297:Male; D008578:Meninges / Q000473:pathology*; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000473:pathology
chemical_list: D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains