title: Anterior pituitary adenylate cyclase: stimulation by dopamine and other monoamines.
abstract: Adenylate cyclase activity of homogenates of anterior pituitary from rat, rabbit and monkey was stimulated by dopamine, other amine neurotransmitters and Gpp(NH)p. The concentration of dopamine for half-maximal stimulation of activity was 2--5 micrometer. Studies with selective agonists and antagonists indicated the presence of dopamine receptors and beta-adrenergic receptors coupled to adenylate cyclase in anterior pituitary. In addition, histamine stimulated activity in rabbit and monkey, but not in rat, anterior pituitary.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002395:Catecholamines / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D000882:Haplorhini; D066298:In Vitro Techniques; D008253:Macaca mulatta; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects
chemical_list: D001679:Biogenic Amines; D002395:Catecholamines; D011954:Receptors, Dopamine; D000262:Adenylyl Cyclases; D004298:Dopamine