5-Hydroxytryptamine and myoclonus induced by 1,2-di-hydroxybenzene (catechol) in the guinea-pig.
Myoclonus induced by catechol in the guinea-pig is not altered by manipulation of cerebral 5-hydroxytryptamine (5-HT). The administration of catechol does not alter brain levels of 5-HT or its metabolite 5-hydroxyindole acetic acid. This form of myoclonus therefore is not of relevance to the 5-HT-sensitive post-anoxic action myoclonus occurring in man.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002396:Catechols / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009207:Myoclonus / Q000139:chemically induced* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D002396:Catechols; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid