Qualitative alterations in plasma esterases in BALB/c mice following the administration of diethylnitrosamine.
Selected non-specific plasma esterases in female BALB/c mice, separated by polyacrylamide gel electrophoresis, were qualitatively altered following treatment of the mice with diethylnitrosamine (DEN). These alterations include a decreased preference for naphthyl butyrate as a substrate relative to naphthyl acetate; decreased sensitivity to enhancement by divalent cations such as Ca2+, Mg2+, and Mn2; and an increased sensitivity to inhibition by eserine. All esterase species affected were also quantitatively altered and some were testosterone-dependent.
D000818:Animals; D002412:Cations / Q000494:pharmacology; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D004950:Esterases / Q000097:blood*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009281:Naphthalenes / Q000494:pharmacology; D009602:Nitrosamines / Q000494:pharmacology*
D002412:Cations; D009281:Naphthalenes; D009602:Nitrosamines; D004052:Diethylnitrosamine; D004492:Edetic Acid; D004950:Esterases