The effect of cyclical administration of levonorgestrel and ethinyloestradiol on blood pressure, body mass, blood glucose and serum triglycerides.
The effects of two differing dosage schedules of ethinyloestradiol and levonorgestrel, taken cyclically as oral contraceptives, on blood pressure, body mass, blood glucose and serum triglycerides were measured. After 12 months there were no significant changes in systolic and diastolic blood pressure or blood glucose levels. There was a small but statistically significant increase in body mass after 1 year in the group taking levonorgestrel 15 microgram and ethinyloestradiol 30 microgram (P < 0,02), but not in the other group, although the mass in this group was significantly increased after 3 months of therapy. There was a statistically significant increase in serum triglycerides in the group taking levonorgestrel 50 microgram with ethinyloestradiol 50 microgram for 11 days, followed by levonorgestrel 125 microgram for 11 days, followed by levonorgestrel 125 microgram with ethinyloestradiol 50 microgram for 10 days. This effect appears to be dose-related and progressive with continued therapy; the significance of these results is discussed.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016912:Levonorgestrel; D009644:Norgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D014280:Triglycerides; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel