Gold nephropathy in juvenile rheumatoid arthritis.
A 2-year-old girl was treated with gold salts for juvenile rheumatoid arthritis. Treatment had to be discontinued when persistent proteinuria was detected. As this case report indicates, close monitoring of the urine is mandatory during treatment with gold salts to detect early signs of toxicity: hematuria followed by casts and then proteinuria as therapy is continued. Histologic examination with electron microscopy will help to differentiate the different forms of gold toxicity. When the findings are consistent with gold-induced renal involvement, therapy should be discontinued. The gold nephropathy usually resolves in time, with no permanent renal damage.
D001171:Arthritis, Juvenile / Q000188:drug therapy*; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D011507:Proteinuria / Q000139:chemically induced / Q000209:etiology
D006052:Gold Sodium Thiomalate