title: [Prophylaxis of immediate and delayed reactions in exogenic allergic bronchial asthma (author's transl)].
abstract: In 14 antigen provocation tests in 12 patients with allergic bronchial asthma, an immediate bronchoconstriction could be demonstrated by whole body plethysmography and a delayed reaction in 6 other cases. The examinations were repeated after a single prophylactic application of 40 mg disodium cromoglicate. By this means, 10 of the 14 immediate reactions and 4 of the 6 delayed reactions could be completely or largely prevented; in 4 and 2 patients respectively the protective effect was unsatisfactory. In longterm experiments over 4--6 months an improvement in the findings was recorded in 9 of the 12 patients. A rare side-effect of disodium cromologlicate therapy is irritation of the respiratory tract, in some cases with not inconsiderable respiratory obstruction.
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D004205:Cromolyn Sodium / Q000009:adverse effects / Q000627:therapeutic use*; D004781:Environmental Exposure; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000517:prevention & control*; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000517:prevention & control*; D008875:Middle Aged
chemical_list: D004205:Cromolyn Sodium
vernacular_title: Prophylaxe von Sofort- und Spätreaktionen bei exogen-allergischem Asthma bronchiale.