Effect of 17 phenyl PGF2 alpha on nasal patency in man.
The effect of three different doses (12.5 microgram, 25 microgram and 50 microgram) of 17 phenyl PGF2 alpha on nasal patency in fourteen patients with vasomotor rhinitis was studied on separate occasions. In all subjects the three doses of the prostaglandin analogue increased nasal patency for varying duration. With the 50 microgram single dose the duration of action ranged between three hours and more than seven hours. There were no side effects in most of the patients.
D015237:Dinoprost / Q000031:analogs & derivatives*; D006801:Humans; D007765:Lacrimal Apparatus / Q000187:drug effects; D014663:Nasal Decongestants; D009666:Nose / Q000187:drug effects* / Q000503:physiopathology; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D012223:Rhinitis, Vasomotor / Q000188:drug therapy* / Q000503:physiopathology
D014663:Nasal Decongestants; D011461:Prostaglandins F, Synthetic; C027042:17-phenylprostaglandin F2alpha; D015237:Dinoprost