[Peroral nitrate therapy in severe cardiac insufficiency following acute myocardial infarct].
Ten patients with severe congestive heart failure after acute myocardial infarction were treated with 40 mg isosorbiddinitrate-retard every 4 hours and additional sublingual nitroglycerine. There was a prompt improvement of hemodynamic parameters which was maintained for 24 hours: pulmonary capillary wedge pressure (PCW) decreased within 10 min from 26 +/- 5 (X +/- SEM) to 17 +/- 2 mm Hg (p less than 0.01) and mean arterial pressure from 109 +/- 7 to 98 +/- 6 mm Hg. The heart rate remained constant, and the cardiac index improved from 2.3 +/- 0.2 to 2.5 +/- 0.21/min/m2. The fall in blood pressure was dependent on the pretreatment pressure: it was significantly greater in patients with elevated blood pressure and only slight in those with a low pretreatment blood pressure. In the presented series of patients neither adverse effects or symptoms nor a critical reduction of blood pressure were observed. Combined oral treatment with isosorbiddinitrate and nitroglycerine can therefore be carried out without invasive blood pressure monitoring.
D000284:Administration, Oral; D000368:Aged; D003692:Delayed-Action Preparations; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D009566:Nitrates / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000008:administration & dosage
D003692:Delayed-Action Preparations; D009566:Nitrates; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate
Perorale Nitrattherapie der schweren Herz-insuffizienz nach akutem Myokardinfarkt.