Effects of selenium and retinoic acid on the metabolism of N-acetylaminofluorene and N-hydroxyacetylamino-fluorene.
Male albino rats were given 4 ppm selenium (Se(as Na2SeO3) in the water, or 0.25% retinoic acid was added to the basal diet for 3 days. Control and treated animals were given 17 mg acetylaminofluorene (AAF)-9-14C or N-hydroxyacetylaminofluorene (NOHAAF)-9-14C/kg body wt. The administration of Se enhanced glucuronyl transferase activity by 100% and inhibited p-nitrophenol-sulfotransferase by 50%. Retinoic acid enhanced the glucuronyl transferase 37% and inhibited the p-nitrophenol-sulfotransferase by 50%. Pretreatment with Se lowered levels of both AAF and NOHAAF in liver tissue by 30%. Se administration lowered the binding of the labeled carcinogens, or metabolites thereof, to the liver DNA and tRNA.
D015073:2-Acetylaminofluorene / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D005449:Fluorenes / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D006881:Hydroxyacetylaminofluorene / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009596:Nitrophenols; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D012643:Selenium / Q000494:pharmacology*; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000037:antagonists & inhibitors; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives*
D005449:Fluorenes; D009596:Nitrophenols; D014801:Vitamin A; D006881:Hydroxyacetylaminofluorene; D014212:Tretinoin; D004247:DNA; D012343:RNA, Transfer; D015073:2-Acetylaminofluorene; D014453:Glucuronosyltransferase; D013466:Sulfurtransferases; C021871:4-nitrophenol-sulfotransferase; D015238:Sulfotransferases; D012643:Selenium