Effect of polychlorinated biphenyls on drug metabolism in Japanese quail and its progeny.
PCB (DP5, 1 and 5 mg/female/day, orally for 40 days) induce microsomal hepatic enzymes (cytochrome P-450, aniline hydroxylase, aldrin epoxidase, p-nitroanisole demethylase, p-nitrophenol: UDPGA-transferase) in adult female Japanese quail. Toxicity of dinitro-o-cresol (DNOC) is reduced in treated animals. High hepatic activity occurs in young quails issued from treated females, but closely related to residue levels, normal enzyme activities are reestablished within 1 month.
D000818:Animals; D003370:Coturnix; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004138:Dinitrocresols / Q000494:pharmacology; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D013997:Time Factors
D004138:Dinitrocresols; D004364:Pharmaceutical Preparations; D011506:Proteins; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases; D014453:Glucuronosyltransferase