Preparation and antibacterial activity upon Micrococcus luteus of derivatives of iturin A, mycosubtilin and bacillomycin L, antibiotics from Bacillus subtilis.
Methylated and acetylated derivatives of iturin A and mycosubtilin and methylated derivatives of bacillomycin L were prepared and their antibacterial activity on Micrococcus luteus was compared with the activity of the original substance. the results obtained show the importance of polar groups for the antibiotic activity of the substances of iturin group.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000138:chemical synthesis / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D008837:Micrococcus / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000138:chemical synthesis / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic