title: Translocation 46XY, t (17;18) (q25;q21) in a mentally retarded boy with progressive eye abnormalities.
abstract: A 10-year-old boy with reciprocal translocation between chromosomes 17 and 18- 46XY,t (17;18) (q25; q21), appeared cytogenetically balanced. The patient was a healthy, thriving boy whose main abnormal feature was moderate mental retardation. However, abnormal ocular signs were present, including macular "fibrosis", optic disc abnormalities with a traction retinal detachment, tapeto-retinal degeneration, and tilting of the disc to the nasal side. These changes are consistent with the ocular changes previously described in the 18q- syndrome, suggesting that there has been a minimal deletion of chromosome material at the 18q21 breakpoint. The case also demonstrates that the ocular changes of the 18- syndrome may be progressive.
mesh_terms: D002648:Child; D002902:Chromosomes, Human, 16-18; D003878:Dermatoglyphics; D005124:Eye Abnormalities; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014792:Visual Acuity