title: Immunoblastic sarcoma with features of Sjögren's syndrome and systemic lupus erythematosus in a patient with immunoblastic lymphadenopathy.
abstract: A patient with immunoblastic lymphadenopathy and features of Sjögren's syndrome and systemic lupus erythematosus is presented. Clinical features included generalized lymphadenopathy, rash, alopecia, and synovitis, with associated laboratory abnormalities of a positive antinuclear factor and double-stranded DNA antibodies, positive lupus band test, and hemolytic anemia. Symptoms of Sjögren's syndrome included dry eyes and mouth and swollen parotid gland; biopsy results of the accessory salivary glands were positive. At autopsy immunoblastic sarcoma was found that involved the myocardium, which stained for both kappa and lambda light chains by immunoperoxidase techniques.
mesh_terms: D000368:Aged; D000743:Anemia, Hemolytic / Q000209:etiology; D000974:Antibodies, Antinuclear / Q000032:analysis; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D009206:Myocardium / Q000276:immunology; D012469:Salivary Glands / Q000473:pathology; D012509:Sarcoma / Q000150:complications*; D012859:Sjogren's Syndrome / Q000209:etiology*
chemical_list: D000974:Antibodies, Antinuclear; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains