title: Anticlotting properties of fragments D from human fibrinogen and fibrin.
abstract: It appeared from our previous studies that Ca2+ concentrations comparable to those occurring in blood protect the C-terminal part of the gamma-chain remnants of fibrin(ogen) fragments D against further plasmin attack. This study shows that purified fibrin(ogen) fragments D formed in the presence of Ca2+ ions have anticlotting activity in vitro, whereas shortening of the gamma-chain remnants leads to loss of such activity.
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D002118:Calcium; D002417:Cattle; D004533:Egtazic Acid; D005338:Fibrin Fibrinogen Degradation Products / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D011108:Polymers; D013918:Thrombin Time
chemical_list: D000925:Anticoagulants; D005338:Fibrin Fibrinogen Degradation Products; D011108:Polymers; D004533:Egtazic Acid; D002118:Calcium