Experimental approaches to the treatment of CNS leukemia.
Some of the current experimental approaches to the treatment of CNS leukemia are reviewed. While small animal models have provided a basic understanding of the pathophysiology of meningeal leukemia, large animal models, particularly the subhuman primate, allow a more detailed examination of the complex dynamics of CNS pharmacokinetics. Principles derived from these models have provided a rational basis for the development of new approaches to the treatment of meningeal leukemia in man.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002408:Catheters, Indwelling; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D000882:Haplorhini; D006801:Humans; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008253:Macaca mulatta; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism; D010477:Perfusion
D000970:Antineoplastic Agents; D008727:Methotrexate