Silymarin, an inhibitor of prostaglandin synthetase.
Silybin (I), silydianin (II) and silychristin (III), the main constituents of silymarin, inhibit the formation of prostaglandins in vitro. The inhibition is log-linearly dependent on the concentration of the effectors.
D000818:Animals; D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D012838:Silymarin / Q000494:pharmacology*; D013270:Stomach / Q000201:enzymology*; D013329:Structure-Activity Relationship
D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids; D012838:Silymarin