[Electrophoretic mobility test in the early diagnosis of malignant tumors; findings in the prestages of cervical and breast cancers].
A double-blind pilot study of 130 female patients was carried out to determine the feasibility and significance of the EM test in the early diagnosis of carcinoma of the female genital organs and breast. Early stages of cervical carcinoma (carcinoma in situ) as well as fibroid adenoma, mastopathy and breast tumors were tested and compared with the results of their manifest forms. Positive results were recorded in 87.5% of the cases of middle-grade to severe epithelial dysplasia (Papanicolaou III and IV) (n = 10) and in 90% of the cases of carcinoma in situ (n = 16). A positive result in 90% of the cases of carcinoma in situ (n = 16). A positive result in 90% of the cases of genital carcinoma was also recorded. In the case of fibroid adenoma (n = 10) and breast tumor (Prechtel I and II) (n = 16), negative results were recorded in 80.8%, whereas in the manifest forms of carcinoma of the breast a positive result of over 95% was shown. As a result of this pilot study, it can be seen that immunological in vitro screening has clinical significance in the early diagnosis of tumors as well as for confirmation of their manifest forms.
D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000032:analysis*; D004676:Myelin Basic Protein; D011230:Precancerous Conditions / Q000175:diagnosis*; D012756:Sheep / Q000276:immunology; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D008222:Lymphokines; D004676:Myelin Basic Protein
Der Elektrophorese-Mobilitäts-(EM-)Test in der Frühdiagnostik maligner Tumoren; Befunde bei Vorstufen des Zervixkarzinoms und Mammakarzinoms.