title: Effects of the epipodophyllotoxin derivative VM 26 in mitosis and in interphase.
abstract: The epipodophyllotoxin derivative VM 26 inhibits entry of mouse mastocytoma cells into mitosis in cell cultures at drug concentrations of 0.01--1 microgram/ml, the cells being arrested in G2 phase of the cell cycle. At higher concentrations, the compound exhibits spindle poison activity which manifests itself in a shortlasting rise in the number of cells arrested in metaphase of mitosis. These cells then disintegrate after a short period of time.
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D007399:Interphase / Q000187:drug effects*; D012515:Mast-Cell Sarcoma / Q000188:drug therapy; D008938:Mitosis / Q000187:drug effects*; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013713:Teniposide / Q000494:pharmacology*
chemical_list: D013713:Teniposide; D011034:Podophyllotoxin