Mucociliary transport in allergic patients with antigen-induced bronchospasm.
Tracheal mucous velocity (TMV) and respiratory mechanics were measured in asymptomatic asthmatic patients with ragweed hypersensitivity before and after inhalation of specific antigen, and with or without cromolyn sodium pretreatment. TMV was measured radiographically, and the airway response to bronchial provocation was monitored by measurements of forced expiratory volume in one sec and specific airway conductance. TMV was significantly less (6.3 +/- 2.3 mm per min, mean +/- SD) in the 6 asymptomatic asthmatic patients than in 7 normal subjects (11.6 +/- 3.6 mm per min, mean +/- SD). In the asthmatic patients, mean TMV diminished to 72 per cent of baseline immediately after bronchial provocation when specific airway conductance was decreased to 65 per cent of baseline or less, with a further decrease in TMV to 47 per cent of baseline after one hour, at which time respiratory mechanics had returned to baseline values. Pretreatment with cromolyn sodium prevented the decrease in TMV after bronchial provocation. We concluded that in asymptomatic patients with allergic asthma, (1) baseline TMV is impaired, (2) inhalation of specific antigen causes a marked decrease in TMV independent of the degree of bronchospasm, and (3) the decrease in TMV may be related to the release of chemical mediators.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000403:Airway Resistance; D000485:Allergens / Q000008:administration & dosage; D001249:Asthma / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000503:physiopathology*; D002923:Cilia; D004205:Cromolyn Sodium / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation; D012119:Respiration; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D013147:Spirometry; D014132:Trachea / Q000503:physiopathology*
D000336:Aerosols; D000485:Allergens; D004205:Cromolyn Sodium