title: Effects of perphenazine enanthate injections on prolactin levels in plasma from schizophrenic women and men.
abstract: Levels of prolactin (PRL) in plasma were determined in schizophrenic women and men after i.m. injections of 50-150 mg perphenazine enanthate (PE). In both sexes PRL levels increased dose-dependently. In men the effect was significant for 2 and in women for 9 days. Biperiden treatment did not influence the effect of PE on the PRL levels. The data support the view that clinically used doses of PE induce a small but significant blockade of central dopamine receptors.
mesh_terms: D000368:Aged; D001712:Biperiden / Q000494:pharmacology; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010546:Perphenazine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012737:Sex Factors; D013997:Time Factors
chemical_list: D001712:Biperiden; D011388:Prolactin; D010546:Perphenazine