T-, B- and Fc-gamma-receptor-bearing lymphocytes in asthma.
T-, B- and Fc-gamma-receptor-bearing lymphocytes were detected using six different membrane markers in patients suffering from asthma having either normal or low serum IgA levels. E rosettes, aE rosettes and a human anti-T lymphocyte antiserum (HTLA) were used for T cell determination. In patients with low serum IgA levels E rosettes were significantly decreased. B lymphocytes were identified by EAC rosette formation and visualization of surface membrane immunoglobulins (SmIg). No significant difference was seen. Fc-gamma-receptor-bearing lymphocytes were assessed by the EA rosette assay and were significantly decreased in asthmatics with normal IgA levels. This result might be explained by the presence of immune complexes.
D000293:Adolescent; D000328:Adult; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001249:Asthma / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology; D002648:Child; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000276:immunology*; D007142:Immunoglobulin gamma-Chains / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D007070:Immunoglobulin A; D007141:Immunoglobulin Fc Fragments; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains