Effects of some anti-rheumatic agents on copper-catalyzed thermal aggregation of gamma globulin.
Gerber has shown that specific anti-rheumatics, D-penicillamine and aurothiomalate, inhibit copper(II)-catalyzed thermal aggregation of human gamma globulin. Various anti-rheumatics were tested for the activity. Steroidal and non-steroidal anti-inflammatory agents were almost ineffective, while a new non-steroidal anti-inflammatory agent, TAI-284 (6-chloro-5-cyclohexyl-1-indancarboxylic acid), was found to be one half as active as aurothiomalate. The structure-activity relationship of TAI-284 derivatives and the mode of action of TAI-284 were investigated.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D003300:Copper / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D005439:Flufenamic Acid / Q000494:pharmacology; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007189:Indans / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D010396:Penicillamine / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D005719:gamma-Globulins / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D007189:Indans; D005719:gamma-Globulins; D006052:Gold Sodium Thiomalate; D004008:Diclofenac; D005439:Flufenamic Acid; D003300:Copper; D003907:Dexamethasone; D011239:Prednisolone; D010653:Phenylbutazone; D010396:Penicillamine; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin