Immunogenecity of hapten-protein conjugates in rabbits and monkeys preimmunized against the carrier protein.
The effect of preimmunization with carrier protein on the subsequent response to immunization with hapten-protein conjugate was investigated. Rabbits immunized against bovine serum albumin (BSA) showed a delay in the production of anti-progesterone antibodies upon immunization with progesterone-11-BSA. After a booster injection with P-11-BSA, however, they achieved antiprogesterone levels comparable to those in animals immunized with P-11-BSA only. Similarly, rhesus monkeys preimmunized with tetanus toxoid (TT) showed a delay in the development of anti-hCG titers when immunized with beta-hCG-TT. Here again, after booster immunizations they achieved anti-hCG levels comparable to those of the control animals.
D000818:Animals; D000917:Antibody Formation; D002352:Carrier Proteins / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology; D005260:Female; D000882:Haplorhini; D006241:Haptens / Q000276:immunology*; D007114:Immunization; D007117:Immunization, Secondary; D008253:Macaca mulatta; D011374:Progesterone / Q000276:immunology; D011506:Proteins / Q000276:immunology*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors
D002352:Carrier Proteins; D006063:Chorionic Gonadotropin; D006241:Haptens; D011506:Proteins; D013745:Tetanus Toxoid; D012710:Serum Albumin, Bovine; D011374:Progesterone