Chemical exposure and intestinal function.
The particular substances that are ingested by individuals are the consequence of their environmental, residential, and occupational exposures. The possible effects of these exposures on intestinal functions can be examined by the evaluation of in vivo or in vitro exposure followed by an in vivo and/or in vitro monitoring of effects. Several examples of the in vivo exposure and in vitro monitoring approach are presented to demonstrate the consequences of oral exposure to either a heavy metal (arsenic), or a herbicide contaminant (2,3,7,8-tetrachlorodibenzo-p-dioxin) or a jet fuel propellant (hydrazine) and the subsequent measurement of either a particular metabolic pathway, or a cell-specific enzyme induction or the development of brush border enzymes are presented.
D000818:Animals; D001149:Arsenates / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity*; D004790:Enzyme Induction / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D006834:Hydrazines / Q000633:toxicity; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D051381:Rats
D001149:Arsenates; D004785:Environmental Pollutants; D006834:Hydrazines; D000072317:Polychlorinated Dibenzodioxins; D014453:Glucuronosyltransferase; D005947:Glucose