Immunosuppression by a mouse tumor resembles antigenic competition.
The intraperitoneal injection of gamma-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of manner similar to the suppression caused by the injection of horse erythrocytes and termed antigenic competition. In both cases, the greatest suppression occurred when the sheep erythrocytes were injected at the same site (intraperitoneal) as the tumor or antigen several days after the tumor or antigen and in a dose of 10(8) erythrocytes or less.
D000818:Animals; D002460:Cell Line; D004912:Erythrocytes / Q000276:immunology; D005720:Gamma Rays; D007165:Immunosuppression Therapy; D008223:Lymphoma / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental; D012756:Sheep / Q000276:immunology; D013045:Species Specificity; D014466:Ultraviolet Rays