Inhibition of tyrosinase by indole compounds and reaction products. Protection by albumin.
Tyrosinase activity decreases as the reaction proceeds and is inhibited by L-3,4-dihydroxyphenylalanine oxidation products. Indole and tryptophan inhibit tyrosinase reaction and bovine albumin protects against end-product(s) inhibition or inactivation. Since the same tyrosinase reaction products are indole compounds and some authors reported the binding of indole derivatives with albumin, it is here suggested that indole intermediates of melanin synthesis inhibit or inactivate tyrosinase.
D001487:Basidiomycota / Q000201:enzymology; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008543:Melanins / Q000494:pharmacology; D008550:Melatonin / Q000494:pharmacology; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D012710:Serum Albumin, Bovine / Q000494:pharmacology*
D007211:Indoles; D008543:Melanins; D012710:Serum Albumin, Bovine; D004295:Dihydroxyphenylalanine; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase; D008550:Melatonin