1,25-dihydroxyvitamin-D-receptor in breast cancer cells.
A specific receptor for 1,25-dihydroxyvitamin D has been demonstrated in a cultured human breast cancer cell line. This is the first such demonstration in any cancer cell. It may explain the high incidence of metastatic bone destruction and hypercalcaemia in this common malignancy, and the limited success of other steroid-receptor assays in predicting the response of breast cancer to therapy.
D001667:Binding, Competitive; D001859:Bone Neoplasms / Q000209:etiology / Q000556:secondary; D001940:Breast / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000378:metabolism*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000378:metabolism*; D006934:Hypercalcemia / Q000209:etiology; D011987:Receptors, Steroid / Q000302:isolation & purification* / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D011987:Receptors, Steroid; D002118:Calcium