Effects of cerulenin on antibiotic-induced lysis of streptococcus faecalis (S. faecium).
Addition of the antibiotic cerulenin to cultures lowered the minimal effective concentration of penicillin G or methicillin required to produce bacterial lysis and killing. This effect was most pronounced at subinhibitory antibiotic concentrations. Cerulenin had no significant effects on lysis or killing induced in the presence of D-cycloserine, fosfomycin, bacitracin, or vancomycin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002569:Cerulenin / Q000494:pharmacology*; D004357:Drug Synergism; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008712:Methicillin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002569:Cerulenin; D007930:Leucine; D010400:Penicillin G; D008712:Methicillin