[Comparative study, in the Allium test, of the cytotoxicity of tubulosine and of 6 synthetized pseudo-tubulosines].
Comparing cytotoxicity of tubulosine and of six newly synthesized pseudo-tubulosines in the Allium test, we have characterized all the current features of protein inhibition. Nevertheless cytotoxicity of the six pseudotubulosines is much weaker. Furthermore, "floating poles anaphasis", a disturbance characteristic of the action of tubulosine, has been found with a lesser intensity with the other compounds.
D004640:Emetine / Q000031:analogs & derivatives* / Q000633:toxicity; D007211:Indoles / Q000032:analysis / Q000633:toxicity; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index / Q000187:drug effects; D011418:Prophase / Q000187:drug effects; D014176:Protein Biosynthesis; D011506:Proteins / Q000037:antagonists & inhibitors
D007211:Indoles; D011506:Proteins; D004640:Emetine
Etude comparative à l'aide du test Allium de la cytotoxicité de la tubulosine et de six pseudotubulosines de synthèse.