Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus.
Somatostatin in concentrations of 10(-6) to 10(-8) M inhibited basal release of thyrotropin releasing factor in organ culture of rat hypothalamus. Norepinephrine in doses of 10(-4)--10(-6) M induced release of thyrotropin releasing factor which increased progressively with time and was temperature and dose dependent. This enhanced thyrotropin-releasing-factor release was inhibited by somatostatin at 10(-6)--10(-8) M.
D000818:Animals; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009924:Organ Culture Techniques; D011863:Radioimmunoassay; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D013696:Temperature; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D009638:Norepinephrine