[Monoclonal gammopathy and platelet function (author's transl)].
This study of 20 patients with monoclonal gammopathy (17 patients with multiple myeloma and 3 patients with Waldenström's syndrome) showed a decreased platlet aggregation induced by ADP and collagen, a reduced platlet retention and a prolonged bleeding time in 25% of the cases in comparison with 30 age- and sex-matched healthy controls. Using Wu and Hoak's technique as increased number of reversible platelet aggregates was observed. There was no relationship between the parameters of primary haemostasis and protein analysis. A disturbed mechanism of primary haemostasis is the main factor responsible for the bleeding diathesis in patients with monoclonal gammopathy.
D000368:Aged; D005260:Female; D006474:Hemorrhagic Disorders / Q000209:etiology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010976:Platelet Count; D008258:Waldenstrom Macroglobulinemia / Q000097:blood*
Monoklonale Gammopathie und Thrombozytenfunktion.