Antigenic variation and increase in pathogenicity in Pseudomonas aeruginosa as a result of growth on glucose or N-hexadecane as sole carbon source.
When Pseudomonas aeruginosa is grown on glucose as opposed to n-hexadecane as the sole carbon source, the antigenicity, virulence, and protein composition of the outer membrane are altered. The hydrocarbon-grown cells demonstrate a 3-log increase in virulence over the glucose-grown cells (in mice). There also appears to be an additional protein present in the outer membrane of the n-hexadecane-grown cells. This protein may contribute to the observed antigenic differences between the two cell types.
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis; D001426:Bacterial Proteins / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism*; D006586:Hexanes / Q000378:metabolism*; D007928:Lethal Dose 50; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D006586:Hexanes; D005947:Glucose