title: [The "hitch-hiking" effect of a selected gene and gamete combination (linkage disequilibrium): the example of 2 closely linked loci in the swine, Hal (halothane sensitivity) and PHI (phosphohexose isomerase)].
abstract: The observation of two lines of pigs selected differently for four generations confirms a recent theoretical work (Thomson, 1977) showing that a possible source of linkage disequilibrium may be the hitch-hiking effect of a selected locus (Hal) on another closely linked neutral locus (PHI).
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle; D002874:Chromosome Mapping; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D005956:Glucose-6-Phosphate Isomerase / Q000235:genetics; D006221:Halothane / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects; D012641:Selection, Genetic; D013552:Swine / Q000235:genetics*
chemical_list: D005956:Glucose-6-Phosphate Isomerase; D006221:Halothane
vernacular_title: Effet d'entraînement d'un gène sélectionné et association gamétique (déséquilibre de "linkage"): l'example de deux locus étroitement liés chez le Porc, Hal (sensibilité à l'halothane) et PHI (phosphohexose isomérase).