Enhancement by chlordiazepoxide of the anticholinergic-induced locomotor stimulation in mice.
Spontaneous locomotor activity has been studied in mice treated with chlordiazepoxide, atropine, and scopolamine, given alone or in combination. Chlordiazepoxide alone increased activity for a short time, while the two anticholinergic drugs produced longer lasting stimulatory effects. Locomotor stimulation was stronger when chlordiazepoxide and anticholinergics were given in combination.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D010276:Parasympatholytics; D002707:Chlordiazepoxide; D001285:Atropine; D012601:Scopolamine