[The effect of anesthetics on the basal secretion of immunoreactive growth hormone in rats].
The authors investigated basal levels of plasma immunoreactive growth-hormone in the rat (R-GH) after administration of 3 different anesthetic drugs: urethan, chloral hydrate and gamma-hdroxy-butyrate (GHB). Lowest R-GH concentrations (5 +/- 3 ng/ml) are observed after urethan; they are significantly higher (15 +/- 4 ng/ml) after chloral hydrate but this anesthetic also causes hyperglycemia (210 +/- 30 mg/100 ml). Normal blood glucose levels are observed under GHB narco-analgesia which elicits a clear-cut R-GH secretory episode (70 +/- 5 ng/ml); basal values (12 +/- 3 ng/ml) are maintained for several hours thereafter.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002697:Chloral Hydrate / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000494:pharmacology; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology
D000777:Anesthetics; D001786:Blood Glucose; D006885:Hydroxybutyrates; D014520:Urethane; D002697:Chloral Hydrate; D013006:Growth Hormone
Incidence des anesthésiques sur la sécrétion basale de l'hormone de croissance immunoréactive chez le rat.