Modulation of E rosette forming activity of human lymphocytes by rosette inhibiting factor (RIF) ann rosette restoring factor (RRF).
The mechanism of action of RIF and RRF on spontaneous rosette formation by human T lymphocytes with SRBC was studied on cells isolated from healthy donors and from patients with active pulmonary tuberculosis. E rosette formation by lymphocytes from healthy donor is inhibited in vitro by RIF. The effect of RIF is reversible since the primary activity of lymphocytes can be restored by contact with RRF. On the other hand, E rosette formation by lymphocytes from tuberculous patients by means of RRF can be depressed by RIF to the starting level. It was found that prostaglandin synthetase inhibitors (indomethacin and RO 20-5720) prevent inhibition or restoration of E rosette activity by RIF and RRF, respectively.
D001782:Blood Donors; D001798:Blood Proteins / Q000494:pharmacology*; D001853:Bone Marrow / Q000276:immunology; D002227:Carbazoles / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000097:blood
D001798:Blood Proteins; D002227:Carbazoles; D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin