Effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracene-induced, two-stage mouse skin carcinogenesis.
The effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracenecroton oil carcinogenesis in mouse skin was tested. Painting deoxycholic acid in addition to croton oil during promotion resulted in the earlier appearance of tumors, a greater tumor incidence, and a larger number of tumors per animal. DMBA initiation followed by either deoxycholic acid or solvents during the promotion period produced no tumors. Animals receiving deoxycholic acid or solvents alone developed no tumors.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D003436:Croton Oil / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004347:Drug Interactions; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D001551:Benz(a)Anthracenes; D003840:Deoxycholic Acid; D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil