Immunoglobulin in Reed-Sternberg and Hodgkin cells.
In eight cases of Hodgkin's disease of various types, Ig was found within approximately one-third of the RS and HD cells. The Ig within each RS and HD cell consisted of gamma heavy chains and both k and lambda light chains. The most probable origin of the Ig would appear to be uptake of IgG-containing immune complexes. The presence of both types of light chain in individual RS and HD cells is inconsistent with an origin of these types of cell from B lymphocytes.
D001402:B-Lymphocytes / Q000276:immunology; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007142:Immunoglobulin gamma-Chains / Q000032:analysis
D007147:Immunoglobulin Light Chains; D007142:Immunoglobulin gamma-Chains