title: Schizontocidal activity of antibiotics against blood-induced Plasmodium gallinaceum infection.
abstract: Comparative studies on the blood schizontocidal activity of antibiotics against Plasmodium gallinaceum infection of chicks have shown that doxycycline, minocycline, demeclocycline, tetracycline and oxytetracycline possess high antimalarial activity as judged by suppression of parasitaemia and extension of survival period. Of these, demeclocycline, tetracycline and oxytetracycline were effective only at high dose level. Chloramphenicol, erythromycin and gentamicin were relatively inactive. Treatment in 5- to 6-day-old established infection of chicks has shown that doxycycline and minocycline are relatively more effective than oxytetracycline and tetracycline in controlling acute infection.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000962:Antimalarials; D002645:Chickens; D002701:Chloramphenicol / Q000627:therapeutic use; D003707:Demeclocycline / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use; D004341:Drug Evaluation; D004917:Erythromycin / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008289:Malaria, Avian / Q000188:drug therapy* / Q000401:mortality; D008911:Minocycline / Q000627:therapeutic use; D010118:Oxytetracycline / Q000627:therapeutic use; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D005839:Gentamicins; D003707:Demeclocycline; D004917:Erythromycin; D002701:Chloramphenicol; D013752:Tetracycline; D008911:Minocycline; D004318:Doxycycline; D010118:Oxytetracycline