The inhibition of corneal vascularization with aortic extracts in rabbits.
A low molecular weight fraction of bovine aortic extract inhibited corneal vascularization and edema in rabbits when administered either subconjunctivally or topically as long as 48 hours after injury. The extract also appeared to enhance the regression of newly formed corneal vessels. Topical administration for as long as two months had no deleterious ocular side effects. Tissue culture experiments showed that analagous fractions prepared from bovine vitreous inhibit endothelial cell growth. The major growth inhibitor of corneal neovascularization was not the Kunitz bovine protease inhibitor.
D000818:Animals; D001011:Aorta / Q000502:physiology*; D007611:Aprotinin / Q000494:pharmacology; D002057:Burns, Chemical / Q000209:etiology; D002417:Cattle; D003315:Cornea / Q000098:blood supply*; D065306:Corneal Injuries; D004487:Edema / Q000517:prevention & control; D004727:Endothelium / Q000166:cytology; D005126:Eye Burns / Q000139:chemically induced; D008297:Male; D008970:Molecular Weight; D009389:Neovascularization, Pathologic / Q000187:drug effects*; D011480:Protease Inhibitors / Q000494:pharmacology; D011817:Rabbits; D012835:Silver Nitrate; D014020:Tissue Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D011480:Protease Inhibitors; D014020:Tissue Extracts; D007611:Aprotinin; D012835:Silver Nitrate