Genetic control of the immune response to the GAT terpolymer. I. Interstrain and interspecies cross-reactive idiotype.
An antiidiotypic antiserum specific for the GAT antibodies of BALB/c mice has been obtained in rabbits. This serum recognizes the GAT idiotype of 13 inbred strains of mice as well as the GAT idiotype present in sera of guinea-pigs, rats and rabbits immunized with GAT. Such an antiidiotypic antiserum should serve as a good reagent to detect putative idiotypic determinants on GAT-specific suppressor factor.
D000818:Animals; D000918:Antibody Specificity; D003429:Cross Reactions; D005802:Genes, MHC Class II; D006168:Guinea Pigs; D007106:Immune Sera; D007130:Immunoglobulin Idiotypes; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D007106:Immune Sera; D007130:Immunoglobulin Idiotypes; D010455:Peptides