Extraordinary hyperbilirubinemia in a neonate with idiopathic hypertrophic pyloric stenosis.
This case describes an extraordinarily elevated total bilirubin level that reverted to normal 9 1/2 wk after Fredet-Ramstedt pyloromyotomy. Although the etiology of jaundice occurring in patients with IHPS remains uncertain, theories implicating inhibition of the glucuronyl transferase system have been proposed. Infants with IHPS have a documented hypergastrinemia. An hypothesis is offered, illustrated by this case, to explain the inhibition of the glucuronyl transferase system with resultant hyperbilirubinemia by the hypergastrinemia of idiopathic hypertrophic pyloric stenosis.
D005078:Exchange Transfusion, Whole Blood; D005755:Gastrins / Q000097:blood; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D006984:Hypertrophy; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D008297:Male; D008722:Methods; D011707:Pyloric Stenosis / Q000150:complications* / Q000601:surgery
D005755:Gastrins; D014453:Glucuronosyltransferase