Interaction among IgE-mediated hypersensitivity reaction, PCA reaction and delayed hypersensitivity reaction (at local skin sites of monkeys).
The effect of the IgE-mediated reaction on the passive cutaneous anaphylaxis (PCA) reaction was studied at local skin sites of monkeys, and we found that the IgE-mediated reaction appeared to enhance the PCA reaction. Interactions among IgE-mediated reaction, PCA reaction and delayed hypersensitivity reaction were also determined. Contact dermatitis induced with DNCB was utilized as the delayed hypersensitivity reaction. The IgE-mediated reactior or PCA reaction, as well as simple serum irritation, enhanced the delayed hypersensitivity reaction. It is thus assumed that the IgE-mediated reaction enhances the PCA reaction and that this in turn accelerates the delayed hypersensitivity reaction.
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology; D000882:Haplorhini; D006967:Hypersensitivity; D006968:Hypersensitivity, Delayed; D007073:Immunoglobulin E / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis; D012882:Skin Tests
D007073:Immunoglobulin E