[Some notes on the specifity of the fluorescence histochemical demonstration of GABA (author's transl)].
The distribution of the GABA in the Purkinje cells of the rat cerebellum was demonstrated by means of modified fluorescence histochemical method according to WOLMAN (1971). Three types of Purkinje cells, with respect to their fluorescence intensity and GABA distribution, were evident. The GABA-fluorescence was strikingly by pharmacological pretreatment. Isonicotinic acid hydrazide, Penicillamine and Chlorpromazine cause a granulation and marked reduction of the fluorescence compound, being normally homogeneous.
D000818:Animals; D002531:Cerebellum / Q000032:analysis*; D002746:Chlorpromazine / Q000494:pharmacology; D006651:Histocytochemistry / Q000379:methods*; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008856:Microscopy, Fluorescence; D010396:Penicillamine / Q000494:pharmacology; D011689:Purkinje Cells / Q000032:analysis* / Q000187:drug effects; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D005680:gamma-Aminobutyric Acid; D010396:Penicillamine; D002746:Chlorpromazine; D007538:Isoniazid
Zur Spezifität des fluororescenzhistochemischen Nachweises der gamma-Aminobuttersäure (GABA).