title: Evidence for the absence of a mutagenic effect of methadone in germ cells of Drosophila melanogaster.
abstract: The compound, methadone, used as a modality in the treatment of heroin addiction, was tested for mutagenic activity in germ cells of Drosophila. Results were negative in tests for sex-linked recessive lethals using feeding and injection procedures. Similarly, results from tests for chromosome breakage and nondisjunction failed to provide evidence of a mutagenic effect.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004331:Drosophila melanogaster / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D008691:Methadone / Q000494:pharmacology*; D009153:Mutagens; D013094:Spermatozoa / Q000187:drug effects; D014960:X Chromosome / Q000187:drug effects
chemical_list: D009153:Mutagens; D008691:Methadone