The site of benzyl penicillin accumulation in Penicillium chrysogenum.
Benzyl penicillin was localized in cells of Penicillium chrysogenum by means of enzymatical and immunological methods, enabling the determination of minute amounts of penicillin. The reactions were performed on ultrathin sections. They allow to determine the antibiotic inside of the cells. The results indicate that benzyl penicillin is present in the vesicles belonging to the Golgi apparatus. Benzyl penicillin is transported from the cytoplasm outside the cell membrane by the Golgi vesicles.
D006056:Golgi Apparatus / Q000032:analysis / Q000378:metabolism*; D008928:Mitochondria / Q000032:analysis; D010400:Penicillin G / Q000032:analysis / Q000378:metabolism*; D010407:Penicillium / Q000648:ultrastructure*; D010408:Penicillium chrysogenum / Q000378:metabolism / Q000648:ultrastructure*; D014617:Vacuoles / Q000032:analysis
D010400:Penicillin G