Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly (Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion.
Previous studies have demonstrated that both the antibody and T-lymphocyte proliferative immune responses to poly(Glu53Lys36Phe11)n (GLphi) are under the control of two major histocompatibility-linked immune response (Ir) genes. One gene, termed Ir-GL phi-alpha, has been mapped to the I-C or I-E subregion of the major histocompatibility complex, while the other, termed Ir-GL phi-beta, has been mapped to the I-A subregion. In this paper we examine the effect of anti-I-region-associated (Ia) antisera on the T-lyphocyte proliferative response to GL phi. Antibodies directed against Ia antigens coded for by genes in either the I-A or I-C subregion were found to inhibit the proliferative response to GLphi. These results suggest that a function mediated by two Ir gene products can be blocked by anit-Ia antisera directed against either one, and thus, that both products are expressed on the cell surface.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002462:Cell Membrane / Q000276:immunology; D005802:Genes, MHC Class II; D005971:Glutamates; D006183:H-2 Antigens / Q000235:genetics; D007518:Isoantibodies; D007519:Isoantigens / Q000235:genetics; D008213:Lymphocyte Activation; D008239:Lysine; D051379:Mice; D010455:Peptides / Q000276:immunology; D010649:Phenylalanine; D013601:T-Lymphocytes / Q000276:immunology*
D005971:Glutamates; D006183:H-2 Antigens; D007518:Isoantibodies; D007519:Isoantigens; D010455:Peptides; D010649:Phenylalanine; D008239:Lysine