Drug-induced neutropenias in the Stockholm region 1976-1977.
Previously we reviewed the incidence and causes of drug-induced neutropenia in the Stockholm region during the years 1973-75. We here present an equivalent study for the years 1976-77. The yearly incidence of drug-induced neutropenia, cytostatics excluded, remained around 0.01%. About one half of the cases were caused by sulphonamides. Among the other causes, antithyroid drugs and phenothiazines were most frequent. The mortality rate was 27%, in contrast to only 2% in our previous study. Of the seven patiets who died, 5 had taken sulphonamides.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D013956:Antithyroid Agents / Q000009:adverse effects; D002648:Child; D004232:Diuretics / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced* / Q000453:epidemiology; D010640:Phenothiazines / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects; D013548:Sweden
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D013956:Antithyroid Agents; D004232:Diuretics; D010640:Phenothiazines; D013449:Sulfonamides