[Effect of axoplasmic flow blockade on enzymic activities and components of the rat muscle adenylate system].
Proteolytic aspartate and alanine aminotransferase, beta-D-galactosidase, N-acetyl-beta-D-glucosaminidase activities, contents of phosphocreatine, AMP + IMP, ADP, ATP were studied in the rat musculi gastrocnemius after denervation and blockade of axoplasmic flow, the latter being caused by 0.05 M colchicin solution applied to the sciatic nerve. Two weeks after denervation and the axoflow disturbance all the indices (except the N-acetyl-beta-D-glucoseaminidase activity) showed uniform changes. A month following the colchicin blockade the phosphocreatine and adenylates contents became normal. A conclusion is made on significance of the axoplasmic flow as a factor performing the trophic function of the nervous system.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000227:Adenine Nucleotides / Q000378:metabolism*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001370:Axonal Transport / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology*; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D001616:beta-Galactosidase / Q000378:metabolism
D000227:Adenine Nucleotides; D010725:Phosphocreatine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase; D003078:Colchicine
Vliianie blokady aksoplazmaticheskogo toka na fermentativnye aktivnosti i komponenty adenilovoĭ sistemy myshts krys.