Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H.
Fourteen mycotoxins were tested for inhibitory effects on ribonucleic acid polymerase of rat liver and Escherichia coli and nuclear ribonuclease H of rat liver and Tetrahymena pyriformis. These enzymes were strongly inhibited by (-)-luteoskyrin, (+)-rugulosin, patulin, and PR toxin.
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000201:enzymology; D005670:Fusarium; D008099:Liver / Q000201:enzymology; D009183:Mycotoxins / Q000494:pharmacology*; D009285:Naphthoquinones / Q000494:pharmacology; D010365:Patulin / Q000494:pharmacology; D010407:Penicillium; D012318:RNA Polymerase I / Q000037:antagonists & inhibitors*; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors*; D051381:Rats; D012260:Ribonucleases / Q000037:antagonists & inhibitors*; D013769:Tetrahymena pyriformis / Q000201:enzymology
D009183:Mycotoxins; D009285:Naphthoquinones; D010365:Patulin; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases; D012318:RNA Polymerase I; D012260:Ribonucleases