Plasma oestrone, oestradiol and gonadotrophin concentrations in postmenopausal patients treated with oestradiol or with a combination of oestradiol and oestriol.
The effect of adding oestriol or oestriol succinate to oestradiol in the treatment of climacteric postmenopausal patients was examined in a cross-over trial. Plasma concentrations of oestrone (E1), oestradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay after collection over a day after each medication. The subjective effect of each therapy was evaluated by the patient herself. The combination of 1 mg oestriol with 2 mg oestradiol did not change the daily profiles of plasma E1, E2, LH and FSH in three out of four patients, compared with only 2 mg of oestradiol. The other combination, 8 mg of oestriol succinate with 1 mg oestradiol, similarly did not change the daily plasma profiles of oestrogens or gonadotrophins, compared with only 1 mg of oestradiol. Neither oestriol succinate changed the clinical response during the treatment of these climacteric patients.
D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D004964:Estriol / Q000008:administration & dosage / Q000627:therapeutic use*; D004970:Estrone / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause; D008875:Middle Aged; D011863:Radioimmunoassay; D013997:Time Factors
D004338:Drug Combinations; D006065:Gonadotropins, Pituitary; D004970:Estrone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004964:Estriol