title: Evaluation of Debrisan as a treatment for leg ulcers.
abstract: Dextranomer beads, a new treatment for leg ulcerations, has been widely promoted. Comparison with simple saline dressings in an animal model demonstrated no significant difference in its ability to decrease the quantitative bacterial count of granulation tissue. In a prospective randomized clinical study it appeared that, in moist exudative venous stasis ulcers, dextranomer beads may be an effective way of decreasing bacterial contamination. In drier ulcerations caused by this ischemia, this difference was not observed. Recognized principles of treatment such as elevation, debridement, physiological protection of granulation tissue, or vascular reconstruction are as important as a particular dressing regimen and must be utilized in the treatment of leg ulcerations.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001458:Bandages; D003911:Dextrans / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D006097:Granulation Tissue / Q000382:microbiology; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000628:therapy; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D013203:Staphylococcal Infections / Q000628:therapy; D014945:Wound Healing; D014946:Wound Infection / Q000628:therapy
chemical_list: D003911:Dextrans; D012965:Sodium Chloride