Effect of oil-attached BCG cell-wall skeleton and thymectomy on the incidence of lung cancer and amyloidosis induced by chemical carcinogens in rabbits.
Intravenous injection of oil-attached BCG cell-wall skeleton showed potent preventive activity for induction of lung cancer by the intrabronchial instillation of chemical carcinogens (3-methylcholanthrene, 4-nitroquinoline 1-oxide) in rabbits. On the other hand, the thymectomized rabbits developed lung cancer by instillation of chemical carcinogens at an 80% incidence, compared to 47.2% in the controls. There were no differences in the appearance of amyloidosis between thymectomized and BCG cell-wall skeleton-treated rabbits and the controls.
D015112:4-Nitroquinoline-1-oxide; D000230:Adenocarcinoma / Q000517:prevention & control*; D000686:Amyloidosis / Q000139:chemically induced*; D000818:Animals; D001500:BCG Vaccine; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D002473:Cell Wall / Q000276:immunology; D008175:Lung Neoplasms / Q000517:prevention & control*; D008748:Methylcholanthrene; D009163:Mycobacterium bovis / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000517:prevention & control; D011817:Rabbits; D013934:Thymectomy / Q000009:adverse effects*
D001500:BCG Vaccine; D008748:Methylcholanthrene; D015112:4-Nitroquinoline-1-oxide