Efficacy of 100 microgram (250 IU) anti-D IgG in the prevention of Rh-haemolytic disease.
In the years 1975-1976, 6,766 unselected (ABO compatible and incompatible) primigravidae parturients with uncomplicated delivery were given 100 microgram (250 IU) anti-D IgG. A total of 4,473 presented for the 6-month control examination. IAGT was positive in 5 cases (0.11%). The 200 microgram (500 IU) dose was administered to 1,543 women. Of these, 962 presented for serological control. IAGT was positive in 1 case (0.10%). The difference is not significant. The findings support the results of previous studies suggesting that 100 microgram anti-D is a sufficient dose to prevent immunization in uncomplicated deliveries.
D004306:Dose-Response Relationship, Immunologic; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007743:Labor, Obstetric; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D007074:Immunoglobulin G; D012204:Rh-Hr Blood-Group System