title: Antigenic analysis of acute hemorrhagic conjunctivitis viruses (enterovirus type 70).
abstract: The antigenic characteristics of enterovirus type 70 (EV 70) were investigated by means of cross and kinetic neutralization tests (NT). Twelve strains of EV 70 isolated in a period from 1971 to 1976 were analyzed using seven rabbit and one monkey hyper-immune sera. All the strains investigated were found to possess a common and prime variant antigens in varying proportions. Accordingly, EV 70 isolates were devided intratypically into three antigenic sub groups; (1) prototype-like (four strain from 1971 to 1972), (2) intermediate, G-10/72-like (two strains from 1972 to 1973), and (3) prime variant, G-2/74-like (six strains from 1974 to 1976) groups. Thus it was considered that EV 70 might represent a virus type with antigenic heterogeneity, and that antigenic drift from the prototype to the prime type may have occurred successively after 1971.
mesh_terms: D015478:Antigens, Heterophile / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D003231:Conjunctivitis / Q000382:microbiology*; D003429:Cross Reactions; D004770:Enterovirus / Q000145:classification / Q000276:immunology*; D004769:Enterovirus Infections / Q000382:microbiology*; D000939:Epitopes; D006801:Humans; D007564:Japan; D009500:Neutralization Tests
chemical_list: D015478:Antigens, Heterophile; D000956:Antigens, Viral; D000939:Epitopes