Cellular changes in tissues of newborn mice infected with Mokola virus: ultrastructural and biochemical changes.
Cellular and biochemical changes which occurred in the tissues of newborn mice infected with Mokola virus, a rabies-related virus (rhabdovirus group), were described. The virus was transmitted along the peripheral nerves and appeared in various tissues of the body, but did not replicate in any except the nervous system, where it manifested its gross effects. While Mokola virus increased the synthesis of glycogen and total protein in infected brain, liver, lung, spleen and heart, it reduced the activity of monoamine oxidase in the brain. Virus multiplication occurred in the normal rough endoplasmic reticulum. During virus reproduction the membranes of the endoplasmic reticulum, Golgi complex and mitochondria were destroyed and replaced by a viral matrix. Virus maturation also occurred within the rough endoplasmic reticulum.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D002531:Cerebellum / Q000648:ultrastructure; D006003:Glycogen / Q000378:metabolism; D007181:Inclusion Bodies, Viral / Q000473:pathology; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012209:Rhabdoviridae; D014777:Virus Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
D011506:Proteins; D006003:Glycogen; D008995:Monoamine Oxidase