[Variation of the inflammatory response of an autologus implant function and viability: mixed and unilateral inflammatory response].
The behaviour of an autologous grafted implant depends upon its viability. In our study, pericardial implants were used as cardiac valves. Results showed that when using fresh live pericardium, an inflammatory response developed destroying it within 8 days. When implants cells were killed without alteration of their antigenicity--in order to prevent rejection--cellular growth and neovascularisation from implantation site occurred leading to a secondary live graft. Controlled killing of the implant seems to be an essential step in order to get live grafts.
D000818:Animals; D004285:Dogs; D006351:Heart Valves / Q000637:transplantation*; D006651:Histocytochemistry; D007249:Inflammation; D014182:Transplantation, Autologous
Variation de la réponse inflammatoire à un implant autologue en fonction de sa viabilité : réponse inflammatoire mixte et unilatérale.