[Induction of interferon by Bacillus subtilis (author's transl)].
Although it is generally admitted that Gram-positive bacteria cannot induce interferon, we were able to show that organisms and cell walls of Bacillis subtilis as well as components obtained through the extraction of endotoxins from Gram-negative bacteria can induce type II interferon. Moreover we have ascertained that those components have the same biological activity as the endotoxins, espcially with regard to their behaviour with B cells of lymphocytes, the results of pyrogen test, the incidence of cycloheximide and their function as inhibitors of bacteriophages. However, it has appeared that chemically they are quite different from the lipopolysaccharide of the Gram-negative bacteria: no lipid A could be detected.
D000818:Animals; D001412:Bacillus subtilis / Q000032:analysis; D001435:Bacteriophages / Q000187:drug effects; D002473:Cell Wall; D003513:Cycloheximide / Q000494:pharmacology; D004731:Endotoxins / Q000032:analysis / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D013347:Subcellular Fractions
D004731:Endotoxins; D007369:Interferon Inducers; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D007372:Interferons; D003513:Cycloheximide
Induction d'interféron par Bacillus subtilis.