Induction of SV40-related transplantation immunity in mice by BK virus-transformed cells.
The reactivity of tumor-specific transplantation antigens (TSTAs) induced by SV40 and BK virus (BKV) was studied in Balb/Ccr mice with SV40-transformed tumor cells (mKSA-4AC). The mice, which had received BKV-transformed mouse or hamster cells, were highly resistant to the challenge with mKSA-4AC. The mKSA-rejected animals, however, were as susceptible as non-immunized ones to the subsequent challenge with Moloney sarcoma virus (Kirsten)-transformed cells. The result shows that BKV-transformed cells have a TSTA immunologically related closely to that induced by SV40.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D001739:BK Virus / Q000276:immunology*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006224:Cricetinae; D000939:Epitopes; D006649:Histocompatibility Antigens / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus / Q000276:immunology; D009368:Neoplasm Transplantation; D011120:Polyomavirus / Q000276:immunology*; D013539:Simian virus 40 / Q000276:immunology*
D000951:Antigens, Neoplasm; D000939:Epitopes; D006649:Histocompatibility Antigens