[Influence of radiotherapy upon tumor accumulation and organ distribution of 57Co-bleomycin in mice with chemically induced squamous cell carcinoma (author's transl)].
Squamous cell carcinoma was induced in male 6 to 8-week old NMRI-mice by application of 9,10-dimethyl-1,2-benzanthracene on the skin. 15 weeks later macroscopically visible skin tumors are developed. Then organ distribution and tumor accumulation of 57Co-Bleomycin (spec. activity 1 mCi/3.3 mg) were studied 1 to 48 hours after injection. In squamous cell carcinoma a high uptake of this tumor-seeking agent can be demonstrated (n = 46). After radiotherapy (100 kV; 1.7 mm Al-filter; 18.8 Gy) (n = 26), however, a significantly reduced uptake of 57Co-Bleomycin in tumor tissue is observed. Possible consequences from these animal studies for tumor scintigraphy with this radiopharmaceutical in man are discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001761:Bleomycin / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000378:metabolism* / Q000532:radiotherapy; D003037:Cobalt Radioisotopes; D008297:Male; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000532:radiotherapy
D003037:Cobalt Radioisotopes; D001761:Bleomycin; D015127:9,10-Dimethyl-1,2-benzanthracene
Einfluss der Strahlentherapie auf Speicherung von 57Co-Bleomycin im Tumor und Verteilung in den Organen bei Máusen mit chemisch induziertem Plattenepithelkarzinom.