[Ketotifen, a selective histamine liberator].
Ketotifen-induced histamine release from isolated rat mast cells is inhibited under conditions of ATP content depletion in the mast cells. The histamine release is a temperature-dependent process and is blocked at a low temperature. It is concluded that ketotifen is a selective histamine liberator. Time course of ketotifen-induced histamine release corresponds with the process of partial cellular uptake of histamine released.
D000818:Animals; D006636:Histamine Release / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D013696:Temperature; D013876:Thiophenes / Q000494:pharmacology*
D010880:Piperidines; D013876:Thiophenes
Ketotifen - izbiratel'nyĭ vysovoboditel' gistamina.