[Effect of inhibitors of polyamine biosynthesis on primary differentiation of mouse egg].
Alpha-Methylornithine, an inhibitor of the synthesis of putrescine does not affect the cleavage of Mouse eggs, cultured in vitro from the 2-cell stage, before blastocyst formation, whereas methylglyoxal-Bis (guanylhydrazone), an inhibitor of the syntheses of spermidine and spermine induces the embryos to become quiescent at about the 8-cell stage; resumption of their development, after transfer to fresh medium, is followed by a delay in cavitation. These results may be related to the biological clock theory for primary differentiation.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D005260:Female; D005306:Fertilization; D006146:Guanidines / Q000494:pharmacology*; D051379:Mice; D008935:Mitoguazone / Q000494:pharmacology*; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010063:Ovum / Q000502:physiology*; D011700:Putrescine / Q000037:antagonists & inhibitors*
D006146:Guanidines; D009952:Ornithine; D008935:Mitoguazone; D011700:Putrescine
Effets de deux inhibiteurs de la biosynthèse des polyamines sur la différenciation primaire de l'oeuf de Souris.