title: Glycosidases in serum of cystic fibrosis patients.
abstract: In a study of eight glycosidases in serum samples from 72 cystic fibrosis patients, 85 cystic fibrosis parents and 34 healthy and diseased controls, significant elevations of mean alpha-glucosidase levels were found in cystic fibrosis patients. All other glycosidases did not show any significant change. Mean alpha-glucosidase levels in obligate heterozygotes were the same as in control individuals. Moreover, alpha-glucosidase levels in cystic fibrosis patients correlated with the degree of clinical impairment as measured by the Schwachman score.
mesh_terms: D000118:Acetylglucosaminidase / Q000097:blood; D000328:Adult; D001192:Arylsulfatases / Q000097:blood; D002648:Child; D003550:Cystic Fibrosis / Q000201:enzymology* / Q000235:genetics; D005966:Glucuronidase / Q000097:blood; D006026:Glycoside Hydrolases / Q000097:blood*; D006801:Humans; D008361:Mannosidases / Q000097:blood; D012016:Reference Values; D005644:alpha-L-Fucosidase / Q000097:blood; D001616:beta-Galactosidase / Q000097:blood
chemical_list: D001192:Arylsulfatases; D006026:Glycoside Hydrolases; D008361:Mannosidases; D001616:beta-Galactosidase; D005966:Glucuronidase; D005644:alpha-L-Fucosidase; D000118:Acetylglucosaminidase