title: [The morphogenesis of chronic hepatitis].
abstract: The concept of chronic hepatitis is very complex. There is no generally recognized definition and no agreement on the nomenclature. In more recent times a subdivision into chronic persisting (CPH) and chronic active (aggressive or progressive) hepatitis (cah) has been proposed. Morphologically CPH has a mononuclear inflammatory infiltration of the portal fields with preservation of the lobules. In positive hepatitis B CPH, orcein-positive milkglass-shaped hepatocytes and washed-out nuclei have recently been established by immunofluorescence. Periportal inflammation (piecemeal necrosis) is characteristic of CAH. Severe forms show hepatocytolysis and confluent necroses in addition. Since there is not always a sharp division between CPH and CAH, an unequivocal diagnosis of clinical, biochemical, serologic and immunological data is required.
mesh_terms: D002908:Chronic Disease; D006505:Hepatitis / Q000473:pathology*; D006801:Humans; D007249:Inflammation; D008099:Liver / Q000473:pathology*; D009336:Necrosis; D011379:Prognosis; D009626:Terminology as Topic
vernacular_title: Die Morphogenese der chronischen Hepatitis.