[Pharmacokinetic study of 14C-carbaryl in pregnant mice (author's transl)].
The distribution of a single oral dose of 1-naphthyl-N-méthyl 14C-carbamate (Carbaryl), a cholinesterase inhibitor, in pregnant mice (18th day) was determined by whole-body autoradiography and 14C-activity counting of main organs. Although most of the 14C was quickly eliminated (24 h), mainly by the biliary route, there was retention in the maternal organs. Placental transfer of the radioactivity was rapid and readily detectable 5 h after administration. Radioactivity in the foetus remained higher than in the maternal kidney, spleen and heart and persisted after birth. Localisation in foetal eye, liver and central nervous system was observed.
D000818:Animals; D001345:Autoradiography; D012721:Carbaryl / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D013997:Time Factors; D014018:Tissue Distribution
D012721:Carbaryl
Etude de la pharmacocinétique du 14C-carbaryl chez la souris gestante.