Comparative metabolism and excretion of adriamycin in man, monkey, and rat.
Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D004317:Doxorubicin / Q000378:metabolism* / Q000652:urine; D005260:Female; D000882:Haplorhini; D006801:Humans; D007700:Kinetics; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D004317:Doxorubicin