title: Focal epithelial hyperplasia in rabbit oral mucosa.
abstract: Several papules on the floor of the mouth and the ventral surface of the tongue of a zinc-deficient rabbit were studied by light and electron microscopy. These papules appeared to be consistent with focal epithelial hyperplasia of man and chimpanzees. There was a concurrence of cytoplasmic vacuolization with the appearance of viral particles within the nucleus. Intranuclear crystalline viral aggregates were frequently observed in the upper spinous cells.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D006965:Hyperplasia; D008297:Male; D009059:Mouth Diseases / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology* / Q000648:ultrastructure; D011817:Rabbits; D012270:Ribosomes / Q000648:ultrastructure; D013577:Syndrome; D014617:Vacuoles / Q000648:ultrastructure; D015032:Zinc / Q000172:deficiency*
chemical_list: D015032:Zinc