Naloxone-reversible analgesic action of SKF 525-A in mice.
SKF 525-A, given i.p. to mice at doses from 50 to 100 mg/kg, had analgesic activity approximately 40% the analgesic potency of d-propoxyphene HCl, a chemically similar narcotic. While the analgesia produced by propoxyphene was totally antagonized by naloxone, however, that produced by SKF 525-A was only partly reversed. We suspect that SKF 525-A may exert its antinociceptive actions partly by an interaction with CNS narcotic receptors and partly by a nonspecific sedating action.
D000700:Analgesics; D000818:Animals; D011431:Dextropropoxyphene / Q000494:pharmacology; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D011335:Proadifen / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects
D000700:Analgesics; D009270:Naloxone; D011335:Proadifen; D011431:Dextropropoxyphene