title: Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats, and guinea pigs.
abstract: Syngeneic tumour transplants to inbred female animal strains were carried out with basaliomas, squamous cell carcinomas and fibrosarcomas of the skin, induced by DMBA (9,10-dimethyl-1,2-benzanthracene) in the mouse, rat and guinea pig. A completely successful transplantation of all tumors was only achieved in the group of fibrosarcomas of the rat when a myocardial suspension of a young rat was used as a "supporting agent". This may be a new immuno-biological aspect in tumor transplantation. In the other groups, five tumors developed in the host animals after a period of latency of 10 months or more. Therefore, it is discussed whether two of these tumors grown in the host rats should be considered spontaneous. In addition I have found no earlier reports in the literature with successful DMBA-induced epidermal tumors transplantations in homologous or syngeneic animal strains. Tumors were grafted on to altogether 100 animals.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D006168:Guinea Pigs; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation / Q000379:methods*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013045:Species Specificity; D014185:Transplantation, Isogeneic
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene