Amydopyrine pancytopenia: detection of leucocytotoxic antibodies by a 51Cr-release test.
Amydopyrine is known to cause agranulocytosis by an immunological mechanism [2]. However, pancytopenia due to amydopyrine is extremely rare and usually mild and transient [3]. This report describes a patient with severe pancytopenia presumably due to amydopyrine sensitivity. Granulocytotoxic and lymphocytotoxic antibodies were detected in the patient's serum using a 51Cr-release test.
D000632:Aminopyrine / Q000009:adverse effects* / Q000276:immunology; D000906:Antibodies / Q000032:analysis*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D002860:Chromium Radioisotopes; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology*; D008875:Middle Aged; D010198:Pancytopenia / Q000139:chemically induced*
D000906:Antibodies; D002860:Chromium Radioisotopes; D000632:Aminopyrine