[Stimulation of pituitary LH and FSH secretion after immunoneutralization of endogenous substance P in the cycling rat].
In the cycling female Rat, administration of substance P antisera performed at noon on the proestrous day provokes a significant increase in LH and FSH serum level, right before or after the preovulatory surges, but had no effect on its occurrence or magnitude. These results suggest that substance P has a normal physiological inhibitory role in gonadotropin regulation.
D000818:Animals; D000937:Antigen-Antibody Reactions; D004971:Estrus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007106:Immune Sera; D007986:Luteinizing Hormone / Q000097:blood*; D011247:Pregnancy; D011359:Proestrus; D011388:Prolactin / Q000097:blood; D051381:Rats; D013373:Substance P / Q000097:blood* / Q000276:immunology
D007106:Immune Sera; D013373:Substance P; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Stimulation de la sécrétion de la LH et de la FSH hypophysaires après immunoneutralisation de la substance P endogène, chez la Ratte cyclique.