Effects of atenolol and propranolol on human performance and subjective feelings.
In a double-blind, double crossover experiment, 18 healthy young men received over 3-day periods either 100 mg atenolol, 80 mg propranolol, or placebo. The subjects underwent various motor and cognitive tests 18 h after each last dose had been taken. Propranolol significantly increased variability of a choice reaction-time task. Scores on various subjective rating scales showed that propranolol had a larger mood elevating effect than atenolol. Heart rate and blood pressure were significantly reduced 24h after atenolol medication; these effects were absent or reduced after propranolol had been given.
D000293:Adolescent; D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D004644:Emotions / Q000187:drug effects*; D005425:Flicker Fusion / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects*; D010919:Placebos; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D014785:Vision, Ocular / Q000187:drug effects
D010919:Placebos; D011412:Propanolamines; D001262:Atenolol; D011433:Propranolol