Inhibition of isolation-induced aggressive behavior with GABA transaminase inhibitors.
Administration of aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG) resulted in a dose-dependent suppression of aggressive behavior and a concomitant increase in brain GABA. The increase in GABA levels persisted beyond the time when AOAA and GAG exerted an anti-aggressive effect. Brain GABA levels remained significantly elevated over controls for 120 h after a single injection of AOAA and 46 h after a single dose of GAG.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000374:Aggression / Q000187:drug effects*; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003864:Depression, Chemical; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012934:Social Isolation; D000637:Transaminases / Q000037:antagonists & inhibitors*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase