[Problems in prenatal diagnosis of neural tube defects (author's transl)].
The determination of AFP in amniotic fluid for the prediction of neural tube defects fails in cases of myelomeningoceles which changes their status from the open to the closed form. AFP values laying in a borderline range require a fundamental clarification by ultrasound examination for the detection of spinal malformation.
D000015:Abnormalities, Multiple / Q000175:diagnosis; D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000032:analysis; D005260:Female; D006801:Humans; D006849:Hydrocephalus; D007231:Infant, Newborn; D008297:Male; D008588:Meningocele / Q000175:diagnosis*; D009436:Neural Tube Defects / Q000175:diagnosis*; D011247:Pregnancy; D013131:Spine / Q000002:abnormalities; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins
Probleme bei der pränatalen Diagnose von Neuralrohrdefekten.