Herbicidins C and E, two new necleoside antibiotics.
Streptomyces saganonensis No. 4075 used for production of herbicidins A and B has also produced other two antibiotics, herbicidins C and E in submerged culture. Isolation of the antibiotics was performed by adsorption on resinous adsorbent followed by elution with aqueous MeOH and completed by silica-gel chromatography. Physico-chemical characteriation revealed that herbicidins C and E are new nucleoside antibiotics having an adenine moiety in their structures. Herbicidins C and E indicated inhibitory activity against germination of chinese cabbage at 12.5 micrograms/ml and 25 micrograms/ml, respectively, and Anacystis nidulans, a blue green algae, at 100 approximately 200 micrograms/ml.
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D000458:Cyanobacteria / Q000187:drug effects / Q000254:growth & development; D005285:Fermentation; D006540:Herbicides / Q000032:analysis* / Q000378:metabolism; D009705:Nucleosides / Q000378:metabolism / Q000494:pharmacology; D011684:Purine Nucleosides / Q000032:analysis; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D006540:Herbicides; D009705:Nucleosides; D011684:Purine Nucleosides