Clonidine induced hyperphagia and weight gain in monkeys.
The effect of the alpha-noradrenergic receptor agonist, clonidine, on food intake and weight was examined in ten adult Stumptail macaque monkeys. An intramuscular injection of 0.1 mg/kg of clonidine HCl for seven consecutive days significantly increased food intake from baseline levels throughout treatment. All but two monkeys gained weight during clonidine treatment with seven animals gaining from 5--15% of their original body weight by the end of 1 week.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D000882:Haplorhini; D008251:Macaca; D008297:Male; D013268:Stimulation, Chemical
D003000:Clonidine