[Saralasin and prediction of the surgical result in renovascular arterial hypertension].
The response of arterial pressure to an infusion of saralasin was compared to the effect of surgical correction of renal vascular lesions (3 to 6 months after surgery) in eleven patients whose hypertension was associated with uni or bilateral stenosis of renal artery. Saralasin was infused after four days of dietary sodium restriction (10-40 mEq/day). An excellent correlation (r = 0.83, p less than 0.005) between the effects of saralasin and surgery was obtained. There was no correlation between the response to saralasin or to surgery and the ratio of renal vein renin activities. It is suggested that saralasin may be a good tool for predicting the effect of surgery in renovascular hypertension, when infused in moderately sodium depleted patients.
D000328:Adult; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000601:surgery*; D006978:Hypertension, Renovascular / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012083:Renin / Q000097:blood; D012504:Saralasin / Q000494:pharmacology
D000804:Angiotensin II; D012083:Renin; D012504:Saralasin
Saralasine et prédiction du résultat chirurgical dans l'hypertension artérielle réno-vasculaire.