title: Regulation of the in vivo immune response to an autologous red blood cell antigen (Hb) by prostaglandins.
abstract: Mice treated with inhibitors of prostaglandin synthetase showed an alteration in the number of spontaneous, anti-autologous erythrocyte antigen (Hb)-antibody-forming cells in the spleens. The number of anti-Hb plaque-forming cells and rosette-forming cells in the peritoneum of mice treated with inhibitors of prostaglandin synthesis was regulated depending on a magniture of the response in the individual experiments. Depletion of T cells after the antithymocyte treatment of animals resulted in a significant diminution of the regulatory action of the prostaglandin synthetase inhibitor. The results indicate that prostaglandins are involved in the regulation of the in vivo anti-Hb autoimmune response mediating the regulatory cell action.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D000941:Antigens / Q000276:immunology*; D001202:Ascitic Fluid / Q000166:cytology; D001323:Autoantibodies / Q000096:biosynthesis*; D001324:Autoantigens / Q000276:immunology*; D016861:Cyclooxygenase Inhibitors; D004912:Erythrocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D051379:Mice; D011453:Prostaglandins / Q000378:metabolism*; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins