title: Heavy metal nephropathy of rodents.
abstract: Heavy metal nephropathy is a pathologic entity of the renal tubular epithelium of rats, evoked by lead, gold, and other heavy metals. It is characterized acutely by coagulative necrosis, subacutely by cortical fibrosis, and chronically by cytomegaly and karyomegaly. Finally, adenomas develop, some of which become malignant.
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D000818:Animals; D002104:Cadmium / Q000633:toxicity; D005260:Female; D006046:Gold / Q000633:toxicity; D006052:Gold Sodium Thiomalate / Q000633:toxicity; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000662:veterinary*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D007855:Lead Poisoning / Q000473:pathology / Q000662:veterinary; D008297:Male; D008630:Mercury Poisoning / Q000473:pathology / Q000662:veterinary; D008670:Metals / Q000633:toxicity*; D051379:Mice; D009400:Nephrosclerosis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D051381:Rats; D012376:Rodent Diseases / Q000139:chemically induced*
chemical_list: D008670:Metals; D002104:Cadmium; D006052:Gold Sodium Thiomalate; D006046:Gold