Mutagenicity tests with griseofulvin.
Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse. It was also tested for its capacity to produce his+ revertants in Salmonella typhimurium. All tests yielded negative results, whereas highly significant effects were recorded in control assays with thio-TEPA.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D003338:Corpus Luteum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006118:Griseofulvin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D012098:Reproduction / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology
D006118:Griseofulvin; D013852:Thiotepa