Studies on the effect of tolbutamide, glibenclamide, HB 699, and glucose on serum insulin and blood glucose in gastro-enterectomized dogs.
The influence of intravenously administered tolbutamide, glibenclamide, HB 699, and glucose on serum insulin and blood glucose kinetics was examined in 36 enterectomized dogs. The substances induced an immediate and long-lasting insulin release even in the absence of all insulinotropic intestinal mediators. Maximum and mean insulin concentrations after treatment, measured for 180 minutes, were markedly higher in resected dogs than in sham operated or non-operated animals. The data suggest that intestinal mediators might be of no importance in vivo for the insulin-releasing activity of the compounds examined, at least in dogs.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004068:Digestive System Physiological Phenomena; D004285:Dogs; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects; D013453:Sulfonylurea Compounds / Q000494:pharmacology; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology; D014628:Vagotomy
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; D014044:Tolbutamide; D005947:Glucose; D005905:Glyburide