Localization and chemical characterization of Plasmodium knowlesi schizont antigens.
The identification of malarial antigens that induce protective immunity could provide a rational basis for developing an effective antimalarial vaccine as well as specific serodiagnostic tests indicative of clinical immune status. Since protective immunity is probably induced by stage-dependent rather than stage-independent antigens, the antigenic composition of different stages of Plasmodium knowlesi has been compared, and a limited chemical characterization undertaken. This information should provide some insight into the types of preparative procedure appropriate for the purification of functionally important malarial antigens.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D010961:Plasmodium / Q000276:immunology*; D012100:Reproduction, Asexual
D000941:Antigens