Isolation and structure elucidation of a novel griseorhodin.
Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A. A second, FCRC-57-U, was found to be identical to griseorhodin C. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D005285:Fermentation; D009285:Naphthoquinones / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification; D013305:Streptomyces griseus / Q000378:metabolism
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones