title: Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.
abstract: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1  and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004274:DNA, Recombinant; D005796:Genes; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D008099:Liver; D051379:Mice; D008807:Mice, Inbred BALB C; D009694:Nucleic Acid Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D004274:DNA, Recombinant; D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains; D007136:Immunoglobulins; D009694:Nucleic Acid Precursors; D012333:RNA, Messenger