Association between HLA and red cell antigens. VII. Survival studies of incompatible red blood cells in a patient with HLA-associated haemagglutinins.
Serum from a multitransfused patient with bladder papilloma was examined. The serum contained anti-Kell as well as polyspecific, cytotoxic HLA antibodies and HLA-associated haemagglutinins. The HLA haemagglutinins were demonstrated by the Auto Analyzer method and reacted predominantly with red blood cells (RBC) from HLA-A28-positive individuals, and were distinctly weaker with all other test cells. Survival studies with 51Cr-RBC from an HLA-A28-positive, Kell-negative donor with strong A28 RBC reactivity were performed. A small component of the RBC showed clearly reduced survival time, while the main component showed nearly normal survival.
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D001787:Blood Group Incompatibility / Q000276:immunology*; D002470:Cell Survival; D005260:Female; D006680:HLA Antigens; D006388:Hemagglutinins; D006801:Humans; D007626:Kell Blood-Group System; D008099:Liver / Q000276:immunology; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology; D012204:Rh-Hr Blood-Group System; D013154:Spleen / Q000276:immunology
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D006680:HLA Antigens; D006388:Hemagglutinins; D007626:Kell Blood-Group System; D012204:Rh-Hr Blood-Group System