title: Effect of chewable fluoride tablets on dental caries in schoolchildren: results after six years of use.
abstract: Two groups of children, initially in the first  and second grades, chewed, rinsed with, and swallowed an acidulated phosphate-fluoride tablet containing 1 mg of fluoride either once or twice a day in school. A control group of children followed the procedure once a day using a placebo tablet. An evaluation after six years of treatments showed that both the once-a-day and the twice-a-day procedures with fluoride tablets effectively reduced the incidence of dental caries.
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003362:Cost-Benefit Analysis; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D004341:Drug Evaluation; D005459:Fluorides / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D010919:Placebos; D013607:Tablets; D014070:Tooth / Q000033:anatomy & histology; D014078:Tooth Eruption
chemical_list: D010919:Placebos; D013607:Tablets; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides