[2,4-dinitro-(pyrimidine-2-yl) thiophenol, a new drug with antimitotic properties].
A new thiopyrimidine derivative has been synthesized. It can inhibit cell multiplication in Chick embryo fibroblasts, in Mouse Ehrlich ascites tumor cells and in Rat hepatoma cells (line Rueber) cultivated in vitro.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002642:Chick Embryo; D003864:Depression, Chemical; D005347:Fibroblasts / Q000187:drug effects; D066298:In Vitro Techniques; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000494:pharmacology* / Q000627:therapeutic use
D011743:Pyrimidines; D013438:Sulfhydryl Compounds
Le "dinitro-2,4 (phyrimidyl-2)-thiophénol", une nouvelle substance à propriétés antimitotiques.