Response of the living organism to dead and fixed dead, enclosed isologous tissue.
Polyethylene tubes closed at both ends and with four perforations in the side walls were filled either with isologous muscle tissue or with formaldehyde-fixed or glutaraldehyde-fixed isologous tissue, and then implanted subcutaneously in rats. As controls, tubes with solutions of the fixatives were implanted. When cell reaction in the tissues surrounding the differently filled tubes was examined, the reaction to untreated necrotic tissue was found to be the least severe.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D003238:Connective Tissue / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology / Q000601:surgery; D062109:Dermatologic Surgical Procedures; D005404:Fixatives / Q000494:pharmacology*; D005557:Formaldehyde / Q000494:pharmacology*; D005976:Glutaral / Q000494:pharmacology*; D007440:Intubation; D009132:Muscles / Q000503:physiopathology* / Q000637:transplantation; D009336:Necrosis; D011095:Polyethylenes; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects; D012879:Skin Physiological Phenomena; D014185:Transplantation, Isogeneic; D014945:Wound Healing
D000447:Aldehydes; D005404:Fixatives; D011095:Polyethylenes; D005557:Formaldehyde; D005976:Glutaral