Effects of passive immunization against morphine on heroin self-administration.
Antimorphine antibodies produced in Rhesus monkeys immunized with morphine-6-hemisuccinate-BSA were passively administered to recipient monkeys trained to self-administer heroin and cocaine. Following antibody administration, changes in heroin self-administration behavior were observed which were similar to those achieved with low doses of naloxone. Both manipulations increased heroin self-administration without affecting cocaine responding.
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage; D003216:Conditioning, Operant / Q000187:drug effects; D000882:Haplorhini; D003932:Heroin / Q000008:administration & dosage; D006556:Heroin Dependence / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007112:Immunity, Maternally-Acquired; D008253:Macaca mulatta; D009020:Morphine / Q000276:immunology*; D009270:Naloxone / Q000494:pharmacology; D012646:Self Administration
D007106:Immune Sera; D009270:Naloxone; D003932:Heroin; D009020:Morphine; D003042:Cocaine