title: [Recommendations for transfusion therapy. Volume substitution, raising oxygen transport capacity and replacement of clotting factors (author's transl)].
abstract: The principal aims of whole blood transfusion therapy are simultaneous volume substitution, raising the oxygen transport capacity and the replacement of clotting factors. The necessary control factors for volume substitution are described. It must be borne in mind that the blood undergoes changes during storage which among other things affects the ability of the blood to transport oxygen and the clotting potential. Not only the destruction of thrombocytes must be considered but also the loss of activity of the proaccelerin and the antihemophilic globulin A. For this reason for massive blood transfusions using older blood conserves it is recommended that the loss of activity be compensated by antihemophilic cryoprecipitate.
mesh_terms: D001692:Biological Transport; D001793:Blood Preservation / Q000379:methods*; D001803:Blood Transfusion / Q000592:standards*; D001810:Blood Volume; D005169:Factor VIII / Q000627:therapeutic use; D006801:Humans; D010100:Oxygen
chemical_list: D005169:Factor VIII; D010100:Oxygen
vernacular_title: Empfehlungen zur Transfusionstherapie. Volumensubstitution, Erhöhung der Sauerstofftransportkapazität und Ersatz von Gerinnungsfaktoren.