Study of the anti-tumor effect of polypeptide pineal extract.
Bovine pineal polypeptide extract (PPE) exerted an anti-tumor effect on mouse-transplantable tumors: mammary cancer (RSM), squamous cell cervical carcinoma (SCC), hepatoma-22a and lympholeukemia LIO-1, and had no effect on Harding-Passey melanoma and leukemia L-1210. It was shown that PPE possessed the ability to decrease the incidence of DMBA-induced mammary adenocarcinomas in rats. The daily administration of 0.5 mg PPE prolonged the life span of rats by 25% and failed to influence spontaneous tumor development. The arguments in favor of a possible mechanism of anti-tumor action of the pineal gland are submitted. It is suggested that the anti-tumor effect of PPE may occur when the syndrome of cancrophilia is induced by tumor transplantation or chemical carcinogens.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D010455:Peptides / Q000276:immunology / Q000494:pharmacology*; D010870:Pineal Gland / Q000032:analysis*; D051381:Rats; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D010455:Peptides; D015127:9,10-Dimethyl-1,2-benzanthracene