Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.
Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5,8,10,14-eicosatetraenoic acid.
D001095:Arachidonic Acids / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism; D006801:Humans; D006880:Hydroxy Acids / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors; D010544:Peroxidases / Q000378:metabolism*; D012459:Salicylates / Q000494:pharmacology*; D013917:Thrombin / Q000378:metabolism
D001095:Arachidonic Acids; D006880:Hydroxy Acids; D016859:Lipoxygenase Inhibitors; D012459:Salicylates; D010544:Peroxidases; D013917:Thrombin; D001241:Aspirin; D007213:Indomethacin