[Behavior of some enzymes of nucleoside catabolism in circulating lymphocytes during paraproteinemia].
The circulating lymphocytes of 16 normal subjects and of 18 patients with paraproteinemia have been characterized by measuring the levels of ADA, AMPA, PNPase, CDA. The results obtained reveal a highly significant increase in PNPase of subjects affected by paraproteinemia as compared to that of normal subjects (p less than 0.005). The fact that the increased enzymatic levels are found mainly in patients not affected by Bence-Jones proteinuria seems to indicate that the evolution of the paraproteinemia disease is in some way related to the intralymphocyte levels of PNPase.
D000659:AMP Deaminase / Q000097:blood*; D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D000368:Aged; D003564:Cytidine Deaminase / Q000097:blood*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009700:Nucleoside Deaminases / Q000097:blood*; D009709:Nucleotide Deaminases / Q000097:blood*; D010265:Paraproteinemias / Q000201:enzymology*; D010430:Pentosyltransferases / Q000097:blood*; D011683:Purine-Nucleoside Phosphorylase / Q000097:blood*
D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D009700:Nucleoside Deaminases; D009709:Nucleotide Deaminases; D000243:Adenosine Deaminase; D003564:Cytidine Deaminase; D000659:AMP Deaminase
Comportamento di alcuni enzimi del catabolismo nucleosidico nei linfociti circolanti in corso di paraproteinemia.