The effect of high dose oxprenolol on stress-induced physical and psychophysiological variables.
The effects of oral oxprenolol (480 mg) and lorazepam (2 mg) on skin conductance, reaction time, critical flicker frequency and self-rating visual analogue scales for anxiety, sedation and concentration were investigated in 6 healthy male volunteers. Oxprenolol exerted a central action similar to lorazepam as shown by a significant lowering of skin conductance and decrease in the number of spontaneous fluctuations during stress, impaired critical flicker frequency and decrease in alertness with reduced concentration.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005425:Flicker Fusion / Q000187:drug effects; D005712:Galvanic Skin Response / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D010096:Oxprenolol / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology; D013997:Time Factors
D010096:Oxprenolol; D008140:Lorazepam