Response-dependent effects of morphine on reinforcing lateral hypothalamic self-stimulation.
The effects of morphine (10mg/kg) on intracranial self-stimulation were studied in three separate test situations, each requiring rats to perform different types of responses. Self-stimulation was depressed in a test of rate of bar-pressing, to a lesser extent in a test of rate of wall-pressing in which a wider range of movements were reinforced, but not in a shuttle-box, with brain stimulation continuously available on one side of box. This resonse dependency suggests that the depressive effect of morphine on bar-pressing for lateral hypothalamic stimulation reflects a performance deficit rather than an effect on the reinforcing value of the stimulation.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D007031:Hypothalamus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects*; D013997:Time Factors
D009020:Morphine