Effects of reserpine on the incidence of 9,10-dimethyl-1,2-benzanthracene-induced tumors in pinealectomised and thymectomised rats.
After reserpine treatment the incidence of dimethyl-benzathrance-induced tumors was found to be significantly higher in pinealectomised rats than in intact or thymectomised ones. A very high rate of DMBA-leukemia was observed in immune deficient pinealectomised rats after reserpine administration. It is therefore suggested that the neuro-endocrine disturbances, due to removal of the pineal gland in the new-born animals, are latent and become evident after reserpine administration, as reflected in an increased tumor incidence.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D007165:Immunosuppression Therapy; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000209:etiology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013934:Thymectomy
D015127:9,10-Dimethyl-1,2-benzanthracene; D012110:Reserpine