[Comparative study of the antibacterial activity of a number of new antibiotics and their combinations in relation to Pseudomonas aeruginosa].
Tobramycin and sisomycin proved to have the highest antibacterial activity against 156 clinical strains of Ps. aeruginosa and were 4--8 times more effective than monomycin, kanamycin, neomycin and to a lesser extent gentamicin. The combination of mecillinam and sisomycin had a synergistic effect with respect to 26 out of 50 strains of Ps. aeruginosa and the combination of mecillinam and tobramycin had a synergistic effect on 18 strains. An antagonistic effect was observed with the use of the above combinations in 3 cases. The effect of the combinations depended on sensitivity of Ps. aeruginosa cultures to the aminoglycoside antibiotic included into the compositions.
D000560:Amdinocillin / Q000494:pharmacology; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004336:Drug Antagonism; D004338:Drug Combinations; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012853:Sisomicin / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D010406:Penicillins; D000560:Amdinocillin; D014031:Tobramycin; D012853:Sisomicin
Sravnitel'noe izuchenie antibakterial'noĭ aktivnosti riada novykh antibiotikov i ikh kombinatsiĭ v otnoshenii sinegnoinoi palochki.