Cardiovascular effects of amphepramone.
The i.v. administration of amphepramone in dogs induced a dose-related depressor reaction. This effect was due to a peripheral myotropic vasodilatation. When the drug was administered intracerebroventricularly it elicited a marked pressor response, due, to the release of catecholamines with its subsequent action on alpha-adrenergic receptors. Small doses of amphepramone administered in dogs, rats and rabbits, induced a sinus tachycardia. Larger doses brought about a sinus bradycardia, bradyarrhythmias, extrasystoles, ventricular bradycardia and ventricular fibrillation or asystolia. The respiratory movements as well as the EEG tracings were depressed by larger doses of amphepramone.
D000818:Animals; D001049:Apnea / Q000139:chemically induced; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D004053:Diethylpropion / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D004562:Electrocardiography; D004569:Electroencephalography; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects
D004053:Diethylpropion