The unstable Hb Genova (beta 28Leu replaced by Pro) in an East African Family. Family study and the effect of splenectomy.
A fifth family with the unstable Hb Genova is reported from Kenya, East Africa. This almost certainly represents an independent mutation. The beneficial effect of splenectomy has been carefully assessed in one member of the family.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006453:Hemoglobinopathies / Q000097:blood / Q000235:genetics* / Q000628:therapy; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D007630:Kenya; D007930:Leucine / Q000097:blood; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011247:Pregnancy; D011392:Proline / Q000097:blood; D013156:Splenectomy
D006455:Hemoglobins, Abnormal; D011392:Proline; D007930:Leucine