[Brain rat histoenzymological changes induced by microsphere injection during ischemia (author's transl)].
The cerebral thrombosis of the rat with 35 micrometer labeled microspheres gives infarcted areas easily seen. After 15 min, in these areas, there is no change in NADH diaphorase-, succinic-dehydrogenase-, mono-amino-oxidase-, glucose-6-phosphate-dehydrogenase-, isocitric dehydrogenase-, lactic-dehydrogenase-, ATPase, alpha galactosidase-, acid phospatase activity. After 2, 4, 6 h all these activities diminish in the neuropil but they are preserved in the neurones for diaphorase, succinic-dehydrogenase and mono-amino-oxidase. The margin of infarcted areas shows a strong staining for acid phosphatase. Before 2 h there is not enzymatic changes neither oedema. This experimental model seems trustly and could be developped.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002545:Brain Ischemia / Q000201:enzymology*; D002544:Cerebral Infarction / Q000201:enzymology*; D006651:Histocytochemistry; D006867:Hydrolases / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D010088:Oxidoreductases; D006867:Hydrolases
Modifications histoenzymologiqes du cerveau de rat au cours de l'ischémie provoquée par injection de microsphères.