title: [Estimation of the contribution of thiophosphamide-induced chromosomal aberrations to perimplantation embryonic mortality in mice].
abstract: Thiotepa-induced perimplantation mortality in mice was analysed cytologically. The contribution of induced chromosomal aberrations to preimplantation embryonic death was studied. Under the influence of 1.25 mg/kg of thiotepa on late spermatids the stop of cleavage division was found at 2--16 cell stage in 27% of the cases and at 17--22 cell stage in 11.9% (totally in 38.9%) as compared to 6% in the controls. The cytogenetic analysis of embryos consisting of 2--16 cells revealed gross structural chromosomal aberrations in 75% metaphases suitable for analysis.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004622:Embryo, Mammalian / Q000187:drug effects; D047108:Embryonic Development; D005260:Female; D005313:Fetal Death; D007621:Karyotyping; D051379:Mice; D011247:Pregnancy; D013852:Thiotepa / Q000494:pharmacology*
chemical_list: D013852:Thiotepa
vernacular_title: Otsenka vklada indutsirovannykh tiofosfamidom khromosomnykh aberratsiĭ v embrional'nuiu smertnost' do implantatsiiu mysheĭ.