Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.
Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.
D000627:Aminophenols / Q000378:metabolism; D000818:Animals; D003414:Crigler-Najjar Syndrome / Q000201:enzymology*; D004195:Disease Models, Animal / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000172:deficiency / Q000378:metabolism*; D006933:Hyperbilirubinemia, Hereditary / Q000201:enzymology*; D007659:Ketones / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013268:Stimulation, Chemical
D000627:Aminophenols; D007659:Ketones; D014453:Glucuronosyltransferase