A pharmacological and in vitro comparison of three oral cephalosporins.
The pharmacology of cephradine, cephalexin and a new oral cephalosporin, cefaclor, has been compared in six volunteers. Cefaclor was absorbed rapidly and was cleared from the serum more rapidly than the other two agents. This was probably partially due to its instability in serum at body temperature, which was investigated. Against a wide range of common pathogens cefaclor was the more active oral cephalosporin. In particular the activity against Neisseria gonorrhoeae and Haemophilus influenzae was of interest.
D000284:Administration, Oral; D001419:Bacteria / Q000187:drug effects*; D002433:Cefaclor / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D002511:Cephalosporins / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D002515:Cephradine / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects
D002511:Cephalosporins; D002433:Cefaclor; D002515:Cephradine; D002506:Cephalexin