Transplantation of hamster buccal pouch carcinoma to neonatal hamsters.
Epidermoid carcinomas of oral mucosa were induced with DMBA in the buccal pouches of hamsters. The well-differentiated primary tumors were allografted into the peritoneal cavities of neonatal hamsters that had been treated with antilymphocyte serum. Solid tumors grew rapidly in the peritoneum and were harvested 6 to 31 days postimplantation. Gross and histopathologic specimens revealed infiltrative masses of tumor that had become more anaplastic than the original tumor. This in vivo model has considerable potential as a means of studying the immunology of oral cancers during tumor progression.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000008:Abdominal Neoplasms / Q000473:pathology; D000708:Anaplasia / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D002610:Cheek; D006224:Cricetinae; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000473:pathology; D014184:Transplantation, Homologous
D015127:9,10-Dimethyl-1,2-benzanthracene