["In vitro" activity of a new cephalosporin (CGP-7174-E or cefsulodin) against "Pseudomonas aeruginosa" (author's transl)].
The minimal inhibitory concentration (MIC) of four betalactamins (carbenicillin, ticarcillin, piperacillin and (CGP-7174-E) against 109 clinical isolates of Pseudomonas aeruginosa was determined by an agar dilution method. CGP-7174-E was the most active (MIC 3.4 micrograms/ml), followed in descending order by piperacillin (MIC 4.9 micrograms/ml), ticarcillin (MIC 22 micrograms/ml) and carbenicillin (MIC 36 microgram/ml). High correlation was found between the MIC of these betalactamins (r greater than 0.60). In 12 strains where MIC for carbenicillin was greater than or equal to 1,024 microgram/ml, MIC for CGP-7174-E was less than or equal to 128 micrograms/ml and less than 16 micrograms/ml in four strains.
D002228:Carbenicillin / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D002511:Cephalosporins; D010406:Penicillins; D002228:Carbenicillin
Activité in vitro d'une nouvelle céphalosporine (CGP-7174-E ou cefsulodin) sur Pseudomonas aeruginosa.