title: In vitro sensitivity of Trichomonas vaginalis and Candida albicans to chemotherapeutic agents.
abstract: Strains of fresh clinical isolates of Trichomonas vaginalis and Candida albicans have been tested in vitro for their sensitivity to eight drugs used in the therapy of monilial and trichomonal vaginitis. Three of the chemotherapeutic agents, chlorchinaldol, clotrimazole and broxyquinoline were effective against both organisms. Tinidazole and metronidazole were active against T. vaginalis. The strains of C. albicans were also sensitive to trichomycin, natamycin and nystatin. Tinidazole was the most effective trichomonacide, clotrimazole and chlorchinaldol were most effective against C. albicans, while chlorchinaldol had the best in vitro effect against both organisms. The ranges of the MICs are compared to values previously reported.
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002750:Chlorquinaldol / Q000494:pharmacology; D003022:Clotrimazole / Q000494:pharmacology; D006912:Hydroxyquinolines / Q000494:pharmacology*; D008795:Metronidazole / Q000494:pharmacology; D010866:Natamycin / Q000494:pharmacology; D009761:Nystatin / Q000494:pharmacology; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology*; D014011:Tinidazole / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D000994:Antitrichomonal Agents; D006912:Hydroxyquinolines; D014011:Tinidazole; D009761:Nystatin; D008795:Metronidazole; D015125:Oxyquinoline; D010866:Natamycin; D002750:Chlorquinaldol; D003022:Clotrimazole