Effects of glucagon on regional blood flow during cardiogenic shock.
We studied the effects of two dosage levels of glucagon infusion on systemic hemodynamic and regional blood flow measurements during experimental cardiogenic shock in monkeys. Cardiogenic shock was induced in monkeys by embolization of coronary arteries with glass microspheres. Glucagon 1 microgram/kg/min was infused in five monkeys and five remaining monkeys received glucagon infusion at 10 micrograms/kg/min. Radioactive microsphere technique was used to measure regional blood flows. During cardiogenic shock, there were significant decreases in heart rate, mean arterial pressure, cardiac output and rate of rise of left ventricular pressure and significant increases in total peripheral resistance. Blood flows to the heart, brain, kidney and splanchnic bed were markedly reduced. Neither dosage level of glucagon produced any significant improvement in systemic hemodynamic or regional blood flow values. Glucagon produced only nonsignificant increases in splanchnic blood flow during cardiogenic shock. These findings suggest that glucagon infusions in dosages of 1 microgram/kg/min and 10 micrograms/kg/min do not improve systemic or regional hemodynamic status in severe cardiogenic shock.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008099:Liver / Q000098:blood supply; D008253:Macaca mulatta; D012039:Regional Blood Flow / Q000187:drug effects; D012770:Shock, Cardiogenic / Q000503:physiopathology*; D014655:Vascular Resistance
D005934:Glucagon