Preservation of carrageenan-induced immune suppression with alleviation of toxicity in aprotinin-treated mice.
Although the immunosuppressive effect of carrageenan was unimpaired in aprotinin-treated mice, the extent of intravascular coagulation induced by this macrophage toxic agent was substantially reduced. Use of antiproteases such as aprotinin may prove beneficial in management of this adverse side effect of certain immunotherapeutic agents.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D007611:Aprotinin / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology* / Q000633:toxicity; D004347:Drug Interactions; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007166:Immunosuppressive Agents; D051379:Mice; D012756:Sheep / Q000276:immunology
D007166:Immunosuppressive Agents; D002351:Carrageenan; D007611:Aprotinin