title: Prostaglandin synthetase and prostaglandin E2 levels in human breast carcinoma.
abstract: Prostaglandin synthetase activity and tissue prostaglandin E2 levels were measured in 53 human breast carcinoma specimens. Each set of data is log-normally distributed. There is a weak but statistically significant correlation between prostaglandin synthetase activity and tissue prostaglandin E2 levels of individual specimens. In addition, in a series of four rat mammary tumors, a rough correlation between prostaglandin synthetase activity and tissue prostaglandin E2 levels was observed. The data suggest a multifactorial explanation for abnormalities of prostaglandin metabolism in human breast cancer.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats
chemical_list: D001095:Arachidonic Acids; D011458:Prostaglandins E; D011451:Prostaglandin-Endoperoxide Synthases