Kinetics of drug-drug interactions: biliary excretion of iodoxamic acid and iopanoic acid in rhesus monkeys.
The dynamic method originally developed for studying the capacity-limited kinetics of the cholecystographic agents iodoxamic acid and iopanoic acid was applied to study the in vivo interactions of these two compounds following coadminstration in the monkey. Results indicate that these interactions are complex. The compounds appear to compete for plasma protein binding sites as well as for binding sites on intrahepatic proteins. The biliary excretion data apparently fit the "ligand exclusion" model in which iopanoic acid acts as an inhibitor and competes with iodoxamic acid for binding to either of two identical sites within the liver. This competition probably is the rate-limiting step in the liver's overall elimination of these radiographic contrast agents.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D000882:Haplorhini; D007457:Iodine Radioisotopes; D007463:Iodobenzoates / Q000378:metabolism*; D007480:Iopanoic Acid / Q000378:metabolism*; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D011485:Protein Binding; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000378:metabolism*
D007457:Iodine Radioisotopes; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007480:Iopanoic Acid