Ascorbate metabolism in the trained monkey.
The metabolic fate of 14C-1-ascorbate was studied in trained monkeys (Macacca fasicularis) by measurement of the 14C in the expired breath, urine, and feces. To minimize stress, each monkey was placed in a restraining primate chair and trained to all experimental procedures prior to the isotope studies. The majority of the 14C-1-ascorbate was absorbed by the trained monkeys and ascorbate turnover increased with increasing plasma levels. The urine of trained monkeys was the major excretion route of 14C-1-ascorbate and its metabolites. less than 2.5% of the 14C-1-ascorbate was oxidized in 24 hr to 14CO2. The 14CO2 production was not changed by diet or the ascorbate nutritional status in the trained monkey. A significant increase in 14CO2 production was measured in an untrained monkey. The metabolic fate of 14C-1-ascorbate in man and the trained monkey was similar. Therefore, the trained monkey could be a study model for ascorbate metabolism in man.
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D002245:Carbon Dioxide / Q000378:metabolism; D005243:Feces / Q000032:analysis; D000882:Haplorhini; D008251:Macaca / Q000378:metabolism*; D008252:Macaca fascicularis / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D012107:Research Design; D012119:Respiration; D013312:Stress, Physiological / Q000378:metabolism*
D002245:Carbon Dioxide; D001205:Ascorbic Acid