A new hydrolase specific for taurine-conjugates of bile acids.
Through the investigation of the bile acid-deconjugation activities of human intestinal anaerobes, a new enzyme was discovered in Peptostreptococcus intermedius which hydrolyzed specifically the taurine-conjugates, but not the glycine-conjugates of bile acids. However, the enzymes in Streptococcus faecalis and Lactobacillus brevis hydrolyzed chiefly the glycine-conjugates.
D001647:Bile Acids and Salts / Q000378:metabolism*; D013293:Enterococcus faecalis / Q000201:enzymology; D006000:Glycocholic Acid / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D007778:Lactobacillus / Q000201:enzymology; D010462:Peptostreptococcus / Q000201:enzymology*; D013045:Species Specificity; D013379:Substrate Specificity; D013656:Taurocholic Acid / Q000378:metabolism
D001647:Bile Acids and Salts; D013656:Taurocholic Acid; D006867:Hydrolases; D006000:Glycocholic Acid