Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat.
Different equimolar doses of d-amphetamine and methylphenidate were compared for their potency in eliciting stereotyped behavior in rats. Although at lower doses d-amphetamine appeared more effective in causing stereotyped gnawing, repetitive body movements, and sniffing, at higher doses methylphenidate at certain times caused a greater incidence of gnawing than did d-amphetamine. Understanding these differences and comparing related biochemical correlates may lead to a better definition of mechanisms underlying psychostimulant effects.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D008774:Methylphenidate; D003913:Dextroamphetamine