The effects of gonadectomy and oestradiol-17 beta on pituitary responsiveness to LH-RH in the adult male marmoset (Callithrix jacchus).
Exogenous luteinizing hormone-releasing hormone (LH-RH) administered in a wide range of doses (0.2-25 micrograms) to intact male marmoset monkeys induced a marked increased in plasma luteinizing hormone (LH) concentrations. Maximum LH concentrations achieved after injection of LH-RH occurred progressively later as the dosage increased. Bilateral orchidectomy sigificantly enhanced pituitary responsiveness to a standard dose (2.0 microgram) of LH-RH, whereas the introduction of oestradiol-17 beta implants effectively inhibited the responses. LH-RH-induced LH release after gonadectomy (with and without oestradiol-17 beta treatment) was similar in males and females. The use of marmosets for appropriate investigation into the physiological role of LH-RH in controlling LH secretion in primates is proposed.
D000818:Animals; D002143:Callitrichinae / Q000502:physiology*; D002369:Castration / Q000662:veterinary*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D000882:Haplorhini; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects*
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone