Genetic determination of the immune response in mice to cells of different histological type.
The intensity of the cellular immune response to strong transplantation antigens of the H-2 complex is related to the histological type of cells taken for immunization. Splenic cells from C3H mice immunized BALB/c mice better than cells of non-lymphoid origin from the same donor. The reverse was observed when, instead of BALB/c mice, C57B1/6 and A/He were used in immunization experiments. Analysis of the inheritance of this immunization pattern studied in mice of the first generation from various crosses between strains (BALB/c, C57B1/6 and A/He) and in mice from backcrosses has demonstrated that this immunization pattern is not inherited as a simple Mendelian character. Therefore, it could be supposed that efficiency of immunological control of cells having different histological types, may be genetically determined.
D000818:Animals; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005802:Genes, MHC Class II; D007106:Immune Sera; D007111:Immunity, Cellular; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology*; D009368:Neoplasm Transplantation; D014184:Transplantation, Homologous
D007106:Immune Sera