title: [Clinical biochemical aspects of the prophylaxis and therapy of senile cataract with zinc aspartate (author's transl)].
abstract: In the aetiology and pathogenesis of senile cataract a disturbed glucose utilisation is found. This reflects a loss of activity of some key enzymes for glycolysis in the lens. These enzymes (ALD, G6PDH, HK, LDH, MDH and phosphofructokinase) are zinc metal enzymes. The decrease in activity of these enzymes can be compensated by the administration of specific cations. With zinc one can improve the impaired glucose metabolism occurring in old age. For the prophylaxis and therapy of senile cataract the prolonged administration of zinc aspartate is indicated. In the presence of magnesium deficiency magnesium salts should also be given. Cation eliminating exogenous or endogenous factors must be taken into consideration.
mesh_terms: D000367:Age Factors; D000368:Aged; D001224:Aspartic Acid / Q000008:administration & dosage; D002386:Cataract / Q000188:drug therapy / Q000517:prevention & control*; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007908:Lens, Crystalline / Q000201:enzymology; D008134:Long-Term Care; D008291:Malate Dehydrogenase / Q000378:metabolism; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D001224:Aspartic Acid; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D005634:Fructose-Bisphosphate Aldolase; D015032:Zinc
vernacular_title: Klinisch-biochemische Aspekte einer Prophylaxe und Therapie der senilen Katarakt mit Zinkaspartat.