Identification and incidence of a urinary fragment of IgG.
Urine from some patients, when concentrated approximately three hundred fold and immunoelectrophoresed against anti-IgG, shows an unexpected additional precipitin line in the alpha-globulin region. This reaction has been shown to be due to the presence of a low molecular weight (approximately 20 000) fragment of the heavy chain of IgG. A retrospective examination of immunoelectrophoretic plates run over a period of five years has revealed that this fragment was present in 30 out of 110 patients.
D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis; D007141:Immunoglobulin Fc Fragments / Q000302:isolation & purification* / Q000652:urine; D007074:Immunoglobulin G / Q000276:immunology / Q000652:urine*; D007143:Immunoglobulin Heavy Chains / Q000302:isolation & purification / Q000652:urine; D010265:Paraproteinemias / Q000276:immunology / Q000652:urine*; D012189:Retrospective Studies
D007106:Immune Sera; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains