title: Acute intoxication with sodium valproate.
abstract: Two epileptic patients developed an acute toxic encephalopathy consisting of altered behavior, deteriorating seizure control, and confusion while taking sodium valproate alone. Serum valproate levels were greater than 100 microgram/ml in both. Toxic symptoms resolved when the dose of valproate was reduced, with a consequent fall in serum concentration of the drug.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000097:blood / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*
chemical_list: D014635:Valproic Acid