American Burkitt's lymphoma-hand-mirror variant. A detailed investigation of cytologic, ultrastructural, and immunologic features.
Previous studies of patients with lymphoid malignancies have suggested a relationship between survival and the presence of more than 40% hard-mirror cells in the bone marrow. This report represents the first detailed study of a patient with American Burkitt's lymphoma with numerous hand-mirror cells in the bone marrow during the course of the disease. The Burkitt cells were atypical because of their hand-mirror configuration in the bone marrow, the presence of cytoplasmic glycogen, the finding of an IgG surface marker, and a strongly positive acid phosphatase staining reaction. The presence of increased numbers of hand-mirror forms in the bone marrow during the course of the patient's illness may have clinical significance, because they were replaced by non-hand-mirror Burkitt cells in the terminal phase. More reports and investigations of patients with large numbers of hand-mirror forms in the bone marrow are needed to elucidate the full significance of this unusual cellular phenomenon.
D000328:Adult; D001365:Axilla; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D002051:Burkitt Lymphoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D002502:Centrioles / Q000648:ultrastructure; D003599:Cytoskeleton / Q000648:ultrastructure; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008858:Microscopy, Phase-Contrast; D008870:Microtubules / Q000648:ultrastructure; D008928:Mitochondria / Q000648:ultrastructure; D011132:Polyribosomes / Q000648:ultrastructure; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D014617:Vacuoles / Q000648:ultrastructure
D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D011947:Receptors, Antigen, B-Cell