Effect of gold salts on adherent mononuclear cells in tissue culture.
Adherent mononuclear cells from normals and patients with rheumatoid arthritis (RA) were isolated and effects of gold salts on cell cultures assessed in vitro. Phagocytic function of adherent mononuclear cells was assessed by the injestion of opsonized chicken red blood cells. Absolute numbers of phagocytic cells were higher in the RA patients than normals. Gold salts in concentrations 0.5-5.0 microgram/ml significantly reduced the numbers of both adherent and phagocytic cells when compared to control cultures. This suppression was particularily marked in the RA patients and was dose and time dependent. However, mononuclear cells surviving incubation with gold salts appeared to maintain phagocytic function in similar proportions to control cultures.
D001172:Arthritis, Rheumatoid / Q000276:immunology; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D006052:Gold Sodium Thiomalate / Q000494:pharmacology*; D006801:Humans; D010586:Phagocytes / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects
D006052:Gold Sodium Thiomalate