In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents.
The binding of sodium aurothiomalate, sodium aurothiosulphate and aurothioglucose to plasma proteins has been  investigated in vitro. All gold compounds were bound to protein at a similar rate and had similar apparent affinity constants and binding capacities. Penicillamine (10 or 100 microgram/ml) was unable to chelate significant amounts of bound gold from plasma protein.
D006051:Aurothioglucose / Q000378:metabolism; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism*; D002614:Chelating Agents / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006046:Gold / Q000378:metabolism*; D006052:Gold Sodium Thiomalate / Q000378:metabolism; D012971:Gold Sodium Thiosulfate / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D010396:Penicillamine / Q000378:metabolism
D001798:Blood Proteins; D002614:Chelating Agents; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D006046:Gold; D012971:Gold Sodium Thiosulfate; D010396:Penicillamine