[Role of 17-beta-estradiol in the synthesis and secretion of prolactin].
In 5 post-menopausal women TSH and prolactin secretions, induced by TRH, were studied before and after treatment with mg 20 of polyestradiol valerate. After this drug, plasma prolactin concentration increased, but no difference was observed in TSH secretion. The data suggest that 17-beta-estradiol doesn't increase the number of TRH receptors on pituitary cell surface, but stimulates prolactin synthesis.
D000367:Age Factors; D000368:Aged; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D011388:Prolactin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin
Role of 17-beta-estradiol in the synthesis and secretion of prolactin.