The effect of native and sonicated double-stranded polyribonucleotides on the course of spontaneous autoimmune disease in NZB and NZB/Swiss F1 mice.
The administration of sonicated fractions of f2 phage polyribonucleotides caused an increased weight loss and deterioration of the clinical state in female NZB mice. Discontinuance of the treatment resulted in an improvement of both the clinical state and the genetically determined autoimmune disorders of these mice. Some potential explanations of this effect are discussed.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003176:Complement C3 / Q000032:analysis; D004247:DNA / Q000276:immunology; D005260:Female; D007372:Interferons / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D008970:Molecular Weight; D011070:Poly I-C / Q000627:therapeutic use; D011131:Polyribonucleotides / Q000627:therapeutic use*; D012330:RNA, Double-Stranded / Q000276:immunology / Q000627:therapeutic use; D013010:Sonication
D000906:Antibodies; D003176:Complement C3; D011131:Polyribonucleotides; D012330:RNA, Double-Stranded; D004247:DNA; D007372:Interferons; D011070:Poly I-C