title: [Endocarditis therapy with high doses of oral doxycycline: Part II: Clinical study (author's transl)].
abstract: Nineteen patients previously treated unsuccessfully, usually with bactericidal antibiotics, received large doses (average: 15-20 mg/kg/day) of oral doxycycline (Vibramycin) after suitable testing for resistance. The good therapeutic results -- complete cure in eleven cases, great improvement in one, doubtful response to doxycycline in four, three failures -- justifies the observation that high oral doses of doxycycline can be considered as an important addition to the possibilities for treatment of endocarditis.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004696:Endocarditis / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D004698:Endocarditis, Subacute Bacterial / Q000188:drug therapy; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013210:Staphylococcus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification
chemical_list: D004318:Doxycycline
vernacular_title: Endokarditis-Therapie mit hochdosiertem Doxycyclin oral. Teil II: Klinische Studie.