title: The antigen-specific signal in T-lymphocyte activation by alloantigen.
abstract: Current concepts of the mechanism of alloactivation of cytotoxic lymphocytes and the identity of the target cell determinants with which they interact are reviewed. The results of a quantitative analysis of the stimulatory activity of different forms of antigen and the role of a costimulator factor are presented. These lead to the conclusions that SD antigens are not the target cell antigens and that existing theories of cytotoxic T cell activation are inadequate. A new theory of activation of alloareactive cytotoxic lymphocytes is proposed.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005976:Glutaral / Q000494:pharmacology; D007519:Isoantigens / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008954:Models, Biological; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014965:X-Rays
chemical_list: D000939:Epitopes; D007519:Isoantigens; D005976:Glutaral