The carboxy-terminal peptides of in vitro precursor and in vivo mature kappa light chains are identical.
Protein structural analysis of several precursor light chains indicates that these in vitro products include a cysteine-containing tryptic peptide that is indistinguishable from the carboxy-terminal tryptic tripeptide present in in vivo mature kappa light chains. It is concluded that although in vitro precursor light chains contain an additional amino-terminal sequence, their carboxy-terminus is the same as that found in in vivo mature light chains.
D000595:Amino Acid Sequence; D000818:Animals; D002474:Cell-Free System; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D003545:Cysteine / Q000378:metabolism; D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D051379:Mice; D009842:Oligopeptides; D010954:Plasmacytoma / Q000276:immunology; D011498:Protein Precursors; D014357:Trypsin / Q000494:pharmacology
D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D009842:Oligopeptides; D011498:Protein Precursors; D014357:Trypsin; D003545:Cysteine