Neonatal low-level lead exposure in monkeys (Macaca fascicularis): effect on two-choice non-spatial form discrimination.
Monkeys were dosed orally with 500 microgram/kg/day of lead as lead acetate from day 1 of life. No overt signs of lead toxicity were observed. At 2--3 years of age they were tested on a two-choice non-spatial form discrimination using a WGTA apparatus. Treated monkeys showed deficits compared to controls on a series of 20 discrimination reversals; there was no difference between the groups in the effect of a series of "overtraining" trials introduced between reversals.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004912:Erythrocytes / Q000378:metabolism; D005556:Form Perception / Q000187:drug effects*; D000882:Haplorhini; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000523:psychology*; D008252:Macaca fascicularis; D011524:Protoporphyrins / Q000097:blood; D012193:Reversal Learning / Q000187:drug effects
D011524:Protoporphyrins; D007854:Lead