Changes in ovarian activity during hepatocarcinogenesis by N-2-fluorenylacetamide: role of alpha-fetoprotein.
During chemical hepatocarcinogenesis by N-2-fluorenylacetamide, the hormonal status of female Sprague Dawley rats is largely modified. Ovaries present a reduced activity which is evidenced by a decreased number of follicles and corpora lutea. The level of progesterone in N-2-fluorenylacetamide treated rats is low and agrees with the lack of corpora lutea. Conversely, estradiol level remains normal. This fact may be explained by the presence of alpha-fetoprotein, a carcino-embryonic protein which binds specifically estrogenic hormones.
D015073:2-Acetylaminofluorene; D000818:Animals; D003338:Corpus Luteum / Q000166:cytology; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005856:Germ-Free Life; D008113:Liver Neoplasms / Q000139:chemically induced / Q000503:physiopathology*; D009374:Neoplasms, Experimental / Q000503:physiopathology; D006080:Ovarian Follicle / Q000166:cytology; D010053:Ovary / Q000473:pathology / Q000503:physiopathology*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins; D011374:Progesterone; D004958:Estradiol; D015073:2-Acetylaminofluorene