Effect of tetrahydroaminoacridine and 4-aminopyridine on recovery from ketamine-diazepam anesthesia in the macacus rhesus monkey.
Tetrahydroaminoacridine (T.H.A., Tacrine) 1 mg/kg, and 4-aminopyridine (Pymadin) 0.2 and 1.0 mg/kg i.v., significantly reduced the recovery time when the were administered after ketamine-diazepam anesthesia in Maccacus Rhesus monkeys. Anesthesia was induced with ketamine (50 mg), diazepam (1.2 mg) and sodium glycopyrrolate (0.02 mg) as a secretiondrying agent, as a single bolus injection. Anesthesia was continued with ketamine by constant infusion of a solution of 5 mg/ml, at a speed of 20 mg/ml, at a speed of 20 ml/hour, during 30 minutes. The 5 monkeys in the control group were allowed to recover spontaneously. The test series consisted of the same monkeys, with an adequate rest period of one or more weeks between anesthesias. Recovery was indicated by production of nystagmus, and by an awake pattern in the EEG. Clinical signs, restlessness and purposeful movements, were also used.
D015761:4-Aminopyridine; D000166:Acridines / Q000494:pharmacology*; D000631:Aminopyridines / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D000818:Animals; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004569:Electroencephalography; D000882:Haplorhini; D007649:Ketamine / Q000037:antagonists & inhibitors*; D008253:Macaca mulatta; D013619:Tacrine / Q000494:pharmacology*
D000166:Acridines; D000631:Aminopyridines; D013619:Tacrine; D007649:Ketamine; D015761:4-Aminopyridine; D003975:Diazepam