title: Combined regional chemotherapy and radiation therapy in the treatment of epidermoid carcinoma in the oro-facial region.
abstract: Followed treatment of oro-facial epidermoid carcinoma by combined chemo- and radiation therapy with eventual surgical intervention. Cytostatic drugs were applied intraarterially. After a monocytostatic treatment trial with Methotrexat (MTX), a combined cytostatic program was worked out utilizing two cytostatic drugs, viz. MTX and Bleomycin (BLM) in a cyclic alternation. Usefulness of chemotherapy and its inclusion into the treatment of epidermoid carcinoma in the oro-facial region was found justified principally in the case of combined therapy. However, the selected intraarterial mode of cytostatic administration is attended by certain drawbacks, mainly of a technical nature and is not suitable for routine application. For this reason, the authors have abandoned the i. a. mode of cytostatic administration in epidermoid oro-facial carcinoma and have adopted systemic application and this in combination with radiation, eventually surgical therapy with the utilization of chemotherapy.
mesh_terms: D001761:Bleomycin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D005153:Facial Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D001761:Bleomycin; D008727:Methotrexate