title: In vitro activity of HR 756, a new cephalosporin, against Neisseria gonorrhoeae.
abstract: The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml.
mesh_terms: D002510:Cephalosporinase / Q000378:metabolism; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology
chemical_list: D002511:Cephalosporins; D010406:Penicillins; D002510:Cephalosporinase