title: Mutagenicity of skin tanning lotions.
abstract: Two lotions that tan skin in the absence of sunlight and their active ingredient, dihydroxyacetone (DHA), are mutagenic in Salmonella typhimurium strain TA100 without metabolic activation. However, addition of S-9 mix that contains Aroclor 1254-induced rat hepatic microsomes enhances significantly the mutagenic activity of all three agents. Both lotions and DHA also cause primary DNA damage as determined by the rec-assay in Bacillus subtilis. The potential human health hazard of these lotions is discussed.
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism; D003358:Cosmetics / Q000494:pharmacology*; D004269:DNA, Bacterial; D004098:Dihydroxyacetone / Q000494:pharmacology*; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D014306:Trioses / Q000494:pharmacology*
chemical_list: D003358:Cosmetics; D004269:DNA, Bacterial; D014306:Trioses; D004098:Dihydroxyacetone