Evidence for a mutagenic effect of the narcotic antagonist, naltrexone, in germ cells of Drosophila.
The narcotic antagonist, Naltrexone, was tested for mutagenicity in Drosophila. The frequency of sex-linked recessive lethals at a non-toxic dose of 10 mg/ml was 0.43% (42 lethals in 9697 X-chromosomes tested) and 0.16% (19/11536) in the controls. The difference is statistically significant (P less than 0.001). Results from large-scale experiments testing for chromosome breakage and nondisjunction were negative.
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009153:Mutagens; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects; D014960:X Chromosome / Q000187:drug effects
D009153:Mutagens; D009270:Naloxone; D009271:Naltrexone