[Action of secretin on the gastric secretion induced by food stimuli, pentagastrin, histamine and the parenteral administration of casein hydrolysate].
In tests on dogs with innervated and vagus denervated miniature stomaches and gastric fistula the action of secretin on the gastric secretion provoked by food stimulants-pentagastrin, histamine and parenteral introduction of casein hydrolysate was studied. Experiments showed the secretin to produce an inhibiting action only on the 2nd phase of the gastric secretion after feeding on 100 g of meat, depresses secretion, called forth with pentagastrin, but it does not affect the secretion induced by sham feeding, histamine and intravenous administration of casein hydrolysate. Hence, secretin displays specific properties, by arresting only the action of gastrin on the gastric glands.
D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D003864:Depression, Chemical; D004285:Dogs; D005502:Food; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D010288:Parenteral Nutrition; D010418:Pentagastrin / Q000494:pharmacology*; D011492:Protein Hydrolysates; D012633:Secretin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013270:Stomach / Q000294:innervation
D002364:Caseins; D011492:Protein Hydrolysates; D012633:Secretin; D006632:Histamine; D010418:Pentagastrin
Deĭstvie sekretina na zheludochnuiu sekretsiiu, vyzvannuiu pishchevymi razdrazhiteliami, pentagastrinom, gistaminom i parenteral'nym vvedeniem gidrolizata kazeina.