title: [Postcoital contraception in primates. II. Examination of STS 153 and STS 287 as interceptives in the baboon (Papio hamadryas)].
abstract: The interceptive activity of 2 new synthesized steroid compounds: STS 153 (17 beta-Phenylaminocarbonyloxy-estra-1,3,5(10)-triene-3-methyl ether and STS 287 (16 alpha-Bromo-17 beta-[N',N'-dimethylhydrazino]-carbonyloxy-estra-1,3,5(10)-triene-3-methyl ether) and of 17 alpha-Ethynylestradiol was investigated in baboons.--Postcoital oral administration of 1--3 mg/kg b. w. STS 153 for 5--7 days and of 1 mg/kg b. w. STS 287 for 5 days resulted in a fertility inhibition of about 90% and 95% respectively. A dose of 2 mg/kg b. w. of ethynylestradiol was necessary to attain complete fertility inhibition. Following administration of STS 153 and STS 287, side effects were not observed. Pharmacokinetic aspects are discussed.
mesh_terms: D000818:Animals; D001682:Biological Availability; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D003283:Contraceptives, Postcoital, Synthetic / Q000378:metabolism / Q000494:pharmacology*; D047108:Embryonic Development / Q000187:drug effects; D004963:Estrenes; D005260:Female; D000882:Haplorhini; D006801:Humans; D010215:Papio / Q000378:metabolism; D011247:Pregnancy
chemical_list: D003281:Contraceptives, Postcoital; D003283:Contraceptives, Postcoital, Synthetic; D004963:Estrenes; C016653:17 beta-phenylaminocarbonyloxy-estra-1,3,5(10)-triene-3-methyl ether
vernacular_title: Postkoitale Kontrazeption bei Primaten. II. Prüfung von STS 153 und STS 287 als Interzeptiva beim Pavian (Papio hamadryas).