[Effect of aggregation inducers and inhibitors on the functional properties and the ultrastructure of platelets].
The influence of inductors and inhibitors of platelet aggregation on certain functional properties and structural peculiarities of platelets are investigated. Inductors of aggregation, such as ADP and thrombin, will cause the calcium binding to the platelet membrane to be diminished, whereas inhibitory substances of platelet aggregation will cause an increase of calcium binding. Inductors increase the number of partially degranulated platelets. Inhibitors, such as triphtazin and papaverin, inhibit these morphological changes.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology
D011458:Prostaglandins E; D000244:Adenosine Diphosphate; D004176:Dipyridamole; D010208:Papaverine; D013917:Thrombin; D002118:Calcium; D004837:Epinephrine
Der Einfluss einiger Induktoren und Inhibitoren der Aggregation auf die funktionellen Eigenschaften und die Ultrastruktur der Blutplättchen.