[Chemotherapy for digestive carcinomas. Results of a phase II clinical trial (author's transl)].
A so-called "phase II" clinical trial was carried out in 89 patients with digestive carcinomas who were treated either by chemotherapy alone or by a combination of surgery and chemotherapy. Thirty-five patients with inoperable tumours received chemotherapy alone without any noticeable improvement. Thirty-two patients had tumours which were operable but with inoperable extension. Palliative chemotherapy, given after surgery to reduce the size of the tumour, resulted in a prolongation of survival. Twenty-two patients with operable tumours without inoperable extension benefited from routine adjuvant chemotherapy.
D001650:Bile Duct Neoplasms / Q000188:drug therapy*; D003110:Colonic Neoplasms / Q000473:pathology; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005472:Fluorouracil / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D009026:Mortality; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D012075:Remission, Spontaneous
D005472:Fluorouracil
Chimiothérapie des cancers digestifs. Résultats d'un essai clinique phase II.