Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.
The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.
D000818:Animals; D003433:Crosses, Genetic; D003470:Culture Media; D004032:Diet; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D005942:Gluconates / Q000633:toxicity; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics*
D003470:Culture Media; D005942:Gluconates; D010734:Phosphogluconate Dehydrogenase