Baboon veno-arterial cardiopulmonary bypass without anticoagulants.
Four hr veno-arterial cardiopulmonary bypass via a median sternotomy utilizing a membrane oxygenator was done in 15 baboons. A comparison of perfusion with and without anticoagulants was made. From this study systemic heparin had no advantage over no anticoagulants. These findings, in a clinically-relevant primate model, suggest that the scientific basis for the use of systemic heparin in membrane oxygenation is unclear.
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001772:Blood Cell Count; D001792:Blood Platelets; D002315:Cardiopulmonary Bypass; D000882:Haplorhini; D006400:Hematocrit; D006493:Heparin / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D008297:Male; D010100:Oxygen / Q000097:blood; D010215:Papio
D000925:Anticoagulants; D006493:Heparin; D010100:Oxygen