Reinforcing properties of nicocodine in the rhesus monkey.
The present study demonstrates that nicocodine is self-administered by the rhesus monkey in cross self-administration experiments. The minimum reinforcing dose is 10 times higher than that of codeine and 100 times higher than that of heroin. At reinforcing doses the rate of self-administered infusions of nicocodine is comparable with those of codeine. Further experiments are necessary to rank order nicocodine as to its positive reinforcing properties among the opiate-like compounds. On the other hand the present experiments demonstrate that nicocodine is an opium-like reinforcing compound.
D000818:Animals; D003061:Codeine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000882:Haplorhini; D003932:Heroin / Q000494:pharmacology; D008253:Macaca mulatta; D009539:Nicotinic Acids / Q000494:pharmacology; D012054:Reinforcement, Psychology; D012646:Self Administration
D009539:Nicotinic Acids; D003932:Heroin; D003061:Codeine