Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa.
Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology; D004336:Drug Antagonism; D005133:Eye Movements / Q000187:drug effects; D000882:Haplorhini; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008251:Macaca; D008253:Macaca mulatta; D008781:Methyltyrosines / Q000494:pharmacology*; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D012559:Schizophrenia / Q000503:physiopathology; D013239:Stereotyped Behavior / Q000187:drug effects
D008781:Methyltyrosines; D010627:Phenethylamines; D007980:Levodopa; D004298:Dopamine; D010634:Phenobarbital