Brief note. Induction of experimental allergic encephalomyelitis in sheep with purified bovine basic protein and adjuvant.
A large animal model for the induction of experimental allergic encephalomyelitis to study the immunological disease parameters through closed-circuit extracorporeal thoracic duct filtration was successfully produced in two different strains of sheep. This study demonstrates the advantages of using a well-defined antigen to obtain both rapid onset of disease and a higher percentage of animals succumbing to the illness.
D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D004676:Myelin Basic Protein / Q000009:adverse effects / Q000276:immunology*; D012756:Sheep
D004676:Myelin Basic Protein