title: Bacillus of Calmette and Guérin and 7, 12-dimethylbenz(a)-anthracene carcinogenesis in mice.
abstract: The effects of single or repeated Bacillus of Calmette and Guérin (BCG) treatment on the onset of tumors induced by the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) injected at birth into Swiss mice were studied. Multiple doses of BCG, given at regular intervals significantly lowered the incidence of carcinogen-induced tumors. The DMBA-induced lung adenomas did not differ morphologically from the ones that appeared in mice simultaneously treated with both DMBA and BCG.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology / Q000628:therapy; D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000628:therapy; D008223:Lymphoma / Q000139:chemically induced / Q000473:pathology / Q000628:therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D013953:Thymus Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000628:therapy
chemical_list: D001500:BCG Vaccine; D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene