title: Effect of beta-blockers on sodium and potassium content of human erythrocytes.
abstract: Recently, hyperpotassemia was reported in patients treated with propranolol, but the mechanism has not yet been delineated. We have investigated the effects of various beta-adrenergic blockers and of D-propranolol on the Na+ and K+ distribution intra- and extracellularly in human erythrocytes. K+ loss and Na+ gain by cells was demonstrated at drug concentrations of 10(-4) M or greater. D-Propranolol was more effective than L-propranolol, whereas pindolol was ineffective. Practolol increased Na+ content but did not influence K+. The results suggest that electrolyte redistribution across cell membranes is not a likely explanation for hyperpotassemia in patients treated with propranolol, or for the local anaesthetic effect of this drug.
mesh_terms: D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010869:Pindolol / Q000494:pharmacology*; D011188:Potassium / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology*; D012964:Sodium / Q000097:blood*
chemical_list: D012964:Sodium; D011433:Propranolol; D010869:Pindolol; D011188:Potassium