[Endocrine disorders in children with neurofibromatosis von Recklinghausen (author's transl)].
Endocrine disturbances have been studied in 4 children with neurofibromatosis von Recklinghausen, aged 5.0-10.5 years. Hypothalamic precocious puberty was seen in three boys; growth hormone deficiency was diagnosed in a girl. After TRH stimulation one boy and the girl showed a diminished TSH-response. Another boy showed a relatively high basal level of TSH and an elevated TSH-response to TRH. All children were euthyroid. Two boys had a hyperprolactinemia even under basal conditions; the one with elevated TSH-response showed an excessive response of prolactin as well. In all our patients a suprasellar tumor caused the endocrine disorders described.
D001254:Astrocytoma / Q000150:complications; D001932:Brain Neoplasms / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004700:Endocrine System Diseases / Q000150:complications*; D005260:Female; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D011388:Prolactin / Q000097:blood; D011629:Puberty, Precocious / Q000150:complications
D011388:Prolactin; D013006:Growth Hormone
Endokrine Störungen bei Kindern mit Neurofibromatose von Recklinghausen.