Patterns of pulmonary maturation in normal and abnormal pregnancy.
Fetal pulmonary maturation may be a variable event depending on various feto-maternal environmental and biochemical influences. The patterns of maturation were studied in 211 amniotic fluid samples from 123 patients (normal 55; diabetes 23; Rh sensitization 19; preeclampsia 26). The phenomenon of globule formation from the amniotic fluid lipid extract and is relation to pulmonary maturity was utilized for this analysis. Validation of this technique is presented. A normal curve was constructed from 22 to 42 weeks; gestation and compared to the abnormal pregnancies. Patients with class A, B, and C diabetes and Rh-sensitized pregnancies had delayed pulmonary maturation. Patients with class D diabetes and preclampsia paralleled the normal course of maturation. A discussion of these results and their possible cause is presented.
D000653:Amniotic Fluid; D001787:Blood Group Incompatibility / Q000150:complications; D004899:Erythroblastosis, Fetal / Q000150:complications; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids; D008168:Lung / Q000196:embryology*; D011225:Pre-Eclampsia / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications; D011250:Pregnancy Complications, Hematologic; D011254:Pregnancy in Diabetics / Q000150:complications; D011296:Prenatal Diagnosis; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis; D012204:Rh-Hr Blood-Group System; D013500:Surface Tension
D008055:Lipids; D012204:Rh-Hr Blood-Group System