Different  behaviour of 19S thyroglobulin extracted from normal thyroid, simple goitre and toxic goitre in polyacrylamide slab gel isoelectric focusing.
19S thyroglobulin (19S TG) was isolated from normal thyroids, simple goitres and one case of toxic goitre (Graves' disease). With isoelectric focusing on polyacrylamide gel slabs (pH 4--6) several bands for each specimen were detected. The migration patterns of the toxic goitre 19S TG were clearly different from the patterns of normal 19S TG and simple goitre 19S TG.
D004591:Electrophoresis, Polyacrylamide Gel; D006042:Goiter / Q000378:metabolism*; D006801:Humans; D005779:Immunodiffusion; D007525:Isoelectric Focusing; D013954:Thyroglobulin / Q000032:analysis* / Q000302:isolation & purification; D013961:Thyroid Gland / Q000032:analysis*
D013954:Thyroglobulin