Twenty-five years of progress in bilirubin metabolism (1952-77).
This review deals with the development of our understanding of the chemistry of bilirubin and its glucuronide derivatives during the years 1952-1977. It examines the relation between haem metabolism and bilirubin formation and our present knowledge of hepatic transport of bilirubin. The heterogeneity of familial hyperbilirubinaemia is discussed.
D000818:Animals; D001663:Bilirubin / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins; D055598:Chemical Phenomena; D002621:Chemistry; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000378:metabolism; D008099:Liver / Q000378:metabolism
D002352:Carrier Proteins; D005965:Glucuronates; D006418:Heme; D014453:Glucuronosyltransferase; D001663:Bilirubin