[Immunologic study of artificial complex antigens obtained from P. aeruginosa lipopolysaccharides].
Artificial antigens were obtained on the basis of the polysaccharide component of P. aeruginosa complexed with an indifferent protein. Immunological study indicated that the specific polysaccharide of P. aeruginosa lipopolysaccharide contained two structures, high molecular and low molecular, having qualitative and quantitative differences in their hydrocarbon composition. Artificial complex antigens possessed serological and immunogenic properties, the low molecular polysaccharide fraction complexed with protein having less pronounced serological and immunogenic activity than polysaccharide and the high molecular fraction complexed with protein. Antificial complex antigens exerted no protective effect in generalized P. aeruginosa infection in rats.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines; D055598:Chemical Phenomena; D002621:Chemistry; D006386:Hemagglutination Tests; D005779:Immunodiffusion; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008970:Molecular Weight; D011134:Polysaccharides / Q000032:analysis; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D011134:Polysaccharides
Immunologicheskoe izuchenie iskusstvennykh komplekenykh antigenov, poluchennykh iz lipopolisakharidov P. aeruginosa.