[delta-9-Tetrahydrocannabinol (THC) inhibition of the membrane transport system for thymidine].
THC decreases 3H-thymidine uptake within 15 sec. after addition of the drug to the culture (L1210 murine lymphoma cells and human lymphocytes). Experiments performed at 0 degrees C indicate that THC has no action on thymidine binding to the carrier. THC in micromolar concentration inhibits DNA synthesis through a alteration of membrane configuration.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D013759:Dronabinol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism*; D013997:Time Factors
D010835:Phytohemagglutinins; D013759:Dronabinol; D013936:Thymidine
Inhibition par le delta-9-tétrahydrocannabinol (THC) du système de transport membranaire de la thymidine.