[Immunostimulating and adjuvant activities of a low molecular weight lipopeptide].
From crude extracts of a Streptomyces strain exhibiting immunopotentiating effects, a tetrapeptide was isolated and its structure established as L Ala leads to D isoGlu leads to L, L Dap comes from Gly. This peptide was devoid of biological activity but its chemical coupling with lauric acid gave a substance endowed with adjuvant and immunostimulating properties. This substance and the corresponding synthetic lauroyltetrapeptide were as active in this respect as the muramyl-dipeptide, thus far considered as the minimal adjuvant-active structure of bacterial cell walls: the presence of a sugar moiety is therefore not a prerequisite for immunopotentiating activities.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D006020:Glycopeptides / Q000276:immunology*; D007850:Lauric Acids; D051379:Mice / Q000276:immunology; D009112:Muramic Acids; D009842:Oligopeptides / Q000302:isolation & purification; D013154:Spleen / Q000276:immunology; D013302:Streptomyces / Q000276:immunology*
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D007850:Lauric Acids; D009112:Muramic Acids; D009842:Oligopeptides
Propriétés immunostimulantes et adjuvantes d'un lipopeptide de faible poids moléculaire.