A model of experimental endotoxin shock in monkeys and its therapeutic control.
The course and therapy of endotoxin shock were studied in 34 monkeys Macaca mulatta. E. coli endotoxin was infused intravenously to conscious animals. The individual responses to a dose of 3 mg . kg-1 exhibited a considerable variability. A part of shocked animals were successfully rescued by a combined infusion of dopamine, hydrocortisone, and dextran; untreated animals died of endotoxin shock. Morphological changes in their parenchymatous organs were little marked in the acute experiment.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003911:Dextrans / Q000627:therapeutic use; D004195:Disease Models, Animal; D004298:Dopamine / Q000627:therapeutic use; D004731:Endotoxins; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D000882:Haplorhini; D006854:Hydrocortisone / Q000627:therapeutic use; D008253:Macaca mulatta; D008297:Male; D012772:Shock, Septic / Q000628:therapy*
D003911:Dextrans; D004731:Endotoxins; D004298:Dopamine; D006854:Hydrocortisone