Conformational requirements at the prostaglandin cyclooxygenase receptor site.
When space-filling models of the peroxy radical precursor of PGG were compared with models of 2(S)-(3-chloro-4-cyclohexylphenyl)propionic acid and other acidic cyclooxygenase inhibitors several common structural features were revealed. This led us to propose a template for synthesising non-steroidal anti-inflammatory drugs (NSAIS's) based on the geometry of the peroxy radical immediately prior to its cyclisation to PGG.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001665:Binding Sites; D016861:Cyclooxygenase Inhibitors; D008958:Models, Molecular; D011451:Prostaglandin-Endoperoxide Synthases; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D011451:Prostaglandin-Endoperoxide Synthases