[Development of a pediatric amino-acid solution for premature and newborn infants following pharmacokinetic principles].
The blood level kinetics of an amino-acid solution following short-term infusions was measured in 25 premature and 5 hypotrophic newborns. From the calculated transfer rates it was possible to compose an amino-acid solution capable of avoiding imbalances. Clinical tests showed that the solution was tolerated well. Balance studies in 10 premature infants demonstrated a positive nitrogen balance from the first day of life on with a 55% retention of administered amino-acid nitrogen.
D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007700:Kinetics; D009584:Nitrogen / Q000378:metabolism; D010288:Parenteral Nutrition; D012996:Solutions
D000596:Amino Acids; D012996:Solutions; D009584:Nitrogen
Entwicklung einer pädiatrischen Aminosäurenlösung für Frühgeborene und Neugeborene nach pharmakokinetischen Gesichtspunkten.