Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?
Different doses of glibenclamide and of 4-transhydroxy-glibenclamide (main metabolite in man) were administered i.p. to rats and blood glucose was measured. The comparison of the doses capable of producing a 30% decrease of the glycemia shows that 4-trans-hydroxy-glibenclamide is about 6.5 times less potent than glibenclamide in our experimental conditions.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005905:Glyburide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006900:Hydroxylation; D007004:Hypoglycemic Agents; D007274:Injections, Intraperitoneal; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D005905:Glyburide