[Effect of 7,8-benzoflavone on the incidence of skin tumors induced by polycyclic hydrocarbons].
Tumours were induced in CBA mice or (C57BL X CBA)F1 hybrids by the application of benz(a)pyrene (BP), 6-methylBP, 6-formylBP or 7,12-dimethylbenzanthracene (DMBA) to the skin. 7,8-benzoflavone (BF) used in combination with the mentioned agents decreased the carcinogenic action of methyl-substituted hydrocarbons--DMBA and 6-methylBP and had no effect on the carcinogenic action of BP and 6-formylBP. It is suggested that the inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons was due to the inhibited oxidation of the methyl group.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D001571:Benzoflavones / Q000494:pharmacology*; D001580:Benzopyrenes; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000453:epidemiology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000453:epidemiology*
D001551:Benz(a)Anthracenes; D001571:Benzoflavones; D001580:Benzopyrenes; D005419:Flavonoids; D015127:9,10-Dimethyl-1,2-benzanthracene
Deĭstvie 7,8-benzoflavona na chastotu vozniknoveniia opukholeĭ kozhi, vyzvannykh politsiklicheskimi uglevodorodami.