Energy-dependent accumulation of Ca2+ by human embryonic lung fibroblasts.
Human embryonic fibroblasts accumulate Ca2+ in the presence of extracellular ATP and Mg2+, the uptake being maximal at 3 mM ATP. Iodoacetic acid, oligomycin and temperatures of 2 degrees C all inhibit the ATP-potentiated uptake suggesting that an active process may be involved in the transport of Ca2+ into these cells under certain conditions.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003080:Cold Temperature; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007461:Iodoacetates / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D009840:Oligomycins / Q000494:pharmacology; D011247:Pregnancy
D007461:Iodoacetates; D009840:Oligomycins; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium