title: A tissue culture model of cartilage breakdown in rheumatoid arthritis. III. Effects of antirheumatic drugs.
abstract: The effects of hydrocortisone, indomethacin, and gold thiomalate on proteoglycan release were assessed in bovine nasal cartilage-rheumatoid synovium cocultures. Of the three agents, only hydrocortisone consistently inhibited both basal and synovium-stimulated cartilage breakdown. Hydrocortisone responsivity was a direct function of the degradative capacity of synovial specimens, and this was equally well demonstrated both in patients receiving long-term therapy and those given perioperative glucocorticoid therapy. The data are consistent with significant hydrocortisone inhibition of lysosomal enzyme-mediated degradation of cartilage.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002356:Cartilage / Q000187:drug effects*; D046508:Culture Techniques; D005260:Female; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011509:Proteoglycans / Q000378:metabolism; D013583:Synovial Membrane
chemical_list: D011509:Proteoglycans; D006052:Gold Sodium Thiomalate; D006854:Hydrocortisone; D007213:Indomethacin