[Effect of drugs used for the prevention of urinary calculi recurrence on the growth and metabolism of young experimental animals].
In the animal experiment should be made clear whether several medicaments which stood the test in the prevention of relapses of urinary calculi may be used without any danger also in the infantile carrier of concrements. For this purpose young rabbits high doses of diuretics, kation exchangers, aluminium oxide, extracts of the root of rubia tinctorum, succinimide and diphosphonate were given. Growth and development of the animals were negatively influenced by the medicaments, with the exception of the kation exchanger and the extracts of the root of rubia tinctorum. Numerous animals died under the administration of duiretics. The results of the examinations of metabolism only partly allow general conclusions. The medicamentous long-term metaphylaxis of the urolithiasis in childhood is also to be used like dietetic restrictions under strong indication and permanent control.
D000537:Aluminum Oxide / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D002411:Cation Exchange Resins / Q000009:adverse effects / Q000627:therapeutic use; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use; D012968:Etidronic Acid / Q000009:adverse effects / Q000627:therapeutic use; D006128:Growth / Q000187:drug effects*; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use; D008660:Metabolism / Q000187:drug effects*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use; D011817:Rabbits; D013388:Succinimides / Q000009:adverse effects / Q000627:therapeutic use; D014545:Urinary Calculi / Q000188:drug therapy*
D002411:Cation Exchange Resins; D004232:Diuretics; D010936:Plant Extracts; D013388:Succinimides; D006852:Hydrochlorothiazide; D000537:Aluminum Oxide; D012968:Etidronic Acid
Der Einfluss verschiedener in der Harnsteinmetaphylaxe verwendeter Medikamente auf das Wachstum und den Stoffwechsel junger Versuchstiere.