Primary intracranial mixed choriocarcinoma and malignant teratoma.
Primary intracranila choriocarcinoma, either alone or with malignant teratoma, is a rare tumor. The 22 reported cases of primary intracranila mixed choriocarcinoma and malignant teratoma are reviewed, and a further case is added. This 4 1/2-year-old girl presented with multiple cranial nerve palsies, panhypopituitarism and markedly elevated blood and urine human chorionic gonadotrophin (HCG) titres. After subtotal removal of the suprasellar tumor, supervoltage radiation was given with a remarkably rapid and complete response. She died 14 months after diagnosis with no evidence of local recurrence nor of distant metastases.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D002822:Choriocarcinoma / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000378:metabolism; D003391:Cranial Nerves; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology; D008297:Male; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D010243:Paralysis / Q000209:etiology; D011247:Pregnancy; D011882:Radiotherapy, High-Energy; D013724:Teratoma / Q000628:therapy*
D000970:Antineoplastic Agents; D006063:Chorionic Gonadotropin