[Modelling modification of chemical mutagenesis in human cells. III. Linear index of protection as the standardized criterion of modification].
The effect of substances with radioprotective activity, APAETP 2,3 (aminopropylaminoethylthiophosphoric acid 2,3), APAETP 3,3 and cystaphos, on chromosome aberrations, induced by thioTEPA in the culture of human lymphocytes was investigated. It is shown that the obtained curves "concentration -- effect" for thioTEPA can be described by equations rho = 1 -- e-(KC + alpha)2 and X = E -(KC + alpha)2 --1 for aberrant cells and for chromosome breaks in the presence of the investigated substances. On the basis of comparison of angle coefficients of regression the unificated characteristic of the efficiency of chemical mutagenesis is proposed: the linear protection index (LPI), with generalizes the effect of modificators in chemical mutagenesis.
D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000187:drug effects*; D003539:Cystaphos / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008433:Mathematics; D008954:Models, Biological; D009153:Mutagens / Q000037:antagonists & inhibitors*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013852:Thiotepa / Q000037:antagonists & inhibitors*
D009153:Mutagens; D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D013852:Thiotepa; D003539:Cystaphos
Modelirovanie modifikatsii khimicheskogo mutageneza v kletkakh cheloveka. Soobshchenie III. Lineĭnyĭ pokazatel' zashchity--unifitsirovannyĭ kriterii modifikatsii.