The effect of gamma-butyrolactone on locomotor activity in the rat.
The effect of gamma-butyrolactone (GBL) on locomotor activity in the rat was studied. Low doses of GBL (100 and 200 mg/kg) had a biphasic effect on activity. Initially, the activity of the rats was reduced, and this reduction was then followed by a period of hyperactivity. The effect of alpha-flupenthixol (50 microgram/kg alpha-FPT), atropine (10 mg/kg), benztroine (25 mg/kg), protriptyline (15 mg/kg), and clomipramine (25 mg/kg) was investigated on this biphasic effect. alpha-FPT reduced the hyperactivity while benztropine potentiated it; atropine, clomipramine, and protriptyline had little effect. It is concluded that the increase in activity could be due to a release of dopamine.
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001590:Benztropine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology; D005663:Furans / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D011530:Protriptyline / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D005663:Furans; D001590:Benztropine; D011530:Protriptyline; D001285:Atropine; D005475:Flupenthixol; D010424:Pentobarbital; D002997:Clomipramine; D015107:4-Butyrolactone; D004298:Dopamine