The failure of prolactin to initiate lactogenesis in the ewe.
Infusion of exogenous prolactin (NIH-P-S11) at 1 mg/h for 10 h into ewes pretreated for 30 days with oestradiol benzoate and progesterone was unable to initiate milk secretion. Similarly primed ewes injected with 10 microgram thyrotrophin releasing hormone also failed to lactate but all ewes injected with dexamethasone (10 mg daily for 5 days) after oestrogen plus progesterone treatment secreted copious quantities of milk. The results suggest that prolactin, itself, is not capable of initiating lactogenesis in the ewe.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D007774:Lactation / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D011388:Prolactin / Q000494:pharmacology*; D012756:Sheep / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D004967:Estrogens; D011374:Progesterone; D013973:Thyrotropin-Releasing Hormone; D003907:Dexamethasone; D011388:Prolactin