Pharmacological activity of some pyrazolo[1,5-a]pyrimidines.
The paper reports the pharmacological activity in vitro and in vivo of a series of pyrazolo[1,5-a]pyrimidine derivatives. Some of these compounds have proved to be active in decreasing the body temperature. They are also very active inhibitors of the guinea-pig lung prostaglandin-sintetase.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008996:Monoamine Oxidase Inhibitors; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats
D016861:Cyclooxygenase Inhibitors; D008996:Monoamine Oxidase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines