Centrally administered neurotensin: activity in the Julou-Courvoisier muscle relaxation test in mice.
Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects on NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002946:Cisterna Magna; D066298:In Vitro Techniques; D007267:Injections; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013997:Time Factors
D013373:Substance P; D009496:Neurotensin; D013973:Thyrotropin-Releasing Hormone; D001920:Bradykinin