[Effect of phthalic esters on lecithin cholesterol acyltransferase].
The in vitro effects of different esters of phthalic acid at increasing levels on the activity of LCAT have been studied using three currently known methods (Mickel and Foulds, Stokke and Norum, Alcindor). Inhibition from phthalates is high. It is proportional to the amounts used and in inverse ratio to the length of the carbon chains.
D003993:Dibutyl Phthalate / Q000494:pharmacology; D004051:Diethylhexyl Phthalate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008968:Molecular Conformation; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000097:blood; D010795:Phthalic Acids / Q000494:pharmacology*; D011143:Polyvinyl Chloride / Q000009:adverse effects
D010795:Phthalic Acids; D003993:Dibutyl Phthalate; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Effets des esters de l'acide phtalique sur la l'cithine-cholestérol-acyltransférase.