Cannabis sativa: ultrastructural changes in organelles of neurons in brain septal region of monkeys.
Ultrastructural studies of layer V pyramidal neurons of the septal region of rhesus monkeys exposed to smoke of active marihuana and of those exposed to intravenous delta-9-THC revealed low volume density and various degrees of fragmentation and disorganization of rough endoplasmic reticulum. In contrast, no changes were observed in these neurons of the septal region of control monkeys (unexposed monkeys and one monkey exposed to smoke of inactive marihuana). There were no significant differences in volume density of mitochondria or golgi apparatus between exposed animals and controls.
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000209:etiology*; D002188:Cannabis; D002452:Cell Count; D013759:Dronabinol / Q000506:poisoning*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D000882:Haplorhini; D008253:Macaca mulatta; D008928:Mitochondria / Q000648:ultrastructure; D012688:Septum Pellucidum / Q000473:pathology* / Q000648:ultrastructure
D013759:Dronabinol