title: Erythromycin and clindamycin resistance in Corynebacterium diphtheriae from skin lesions.
abstract: Erythromycin- and clindamycin-resistant Corynebacterium diphtheriae isolates were recovered from skin lesions. Resistance to erythromycin and clindamycin was induced by a subinhibitory concentration (0.03 microgram/ml) of erythromycin. Clindamycin (0.07 microgram/ml) was a more effective inducer of its own resistance than of erythromycin resistance. Erythromycin-inducible cross-resistance to vernamycin B alpha was demonstrated in disk diffusion tests.
mesh_terms: D002981:Clindamycin / Q000494:pharmacology*; D003353:Corynebacterium diphtheriae / Q000187:drug effects* / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D012874:Skin Diseases, Infectious / Q000382:microbiology*; D013997:Time Factors
chemical_list: D002981:Clindamycin; D004917:Erythromycin