Episodic and TRH induced growth hormone release in primary hypothyroidism of man and rat.
In 27 hypothyroid subjects studied over 20 to 120 minutes, the concentration of serum growth hormone (GH) was variable with the amplitude and frequency of the secretory patterns similar to those reported by others for normal individuals. Serum GH, after the administration of thyrotropin releasing hormone (TRH) did not differ from values observed as spontaneous surges, in contrast to a consistent increase in thyrotropin and prolactin. Episodic secretion of GH persisted in thyroidectomized rats and did not differ significantly from that present in intact controls. It is concluded that episodic GH secretion is not abolished in primary hypothyroidism and that TRH is not a constant GH secretagogue in human subjects with hypothyroidism.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D051381:Rats; D013973:Thyrotropin-Releasing Hormone; D013997:Time Factors
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013006:Growth Hormone