[Viral acanthomas and specialized forms of keratinosome "membrane coating granules" (author's transl)].
In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epithelium. The participation of intercellular extruded "wagon-wheel" bodies, MVB and atypical keratinosomes on an irregular baso-apical diffusion-barrier in the epidermis of cases with viral acanthomas has been discussed. On the basis of the relation seen between MVB and the Golgi-apparatus, their transition to partially atypical keratinosomes in cases of viral acanthomas and their "expulsion" into the intercellular space could indicate that in keratinozytes the enzymatically regulated feed-back between the cellular surface and the capability to synthesize is changed by viral agents. The interference appears to manifest itself in the Golgi-apparatus and also appears to be "specified" by the terrain present.
D003218:Condylomata Acuminata / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D000078404:Epidermal Cells; D004817:Epidermis / Q000473:pathology; D005110:Extracellular Space; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D007633:Keratins / Q000096:biosynthesis*; D007636:Keratoacanthoma / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008566:Membranes / Q000648:ultrastructure; D008854:Microscopy, Electron; D014780:Viruses / Q000302:isolation & purification
D007633:Keratins
Virusacanthome und besondere Formen von Keratinosomen "Membrane Coating Granules".