Effects of prostaglandins and some anti-inflammatory drugs on the binding of 7,12-dimethylbenz[alpha]anthracene to the DNA of murine epidermal cells in culture.
The effects of prostaglandins (PG) E1, E2, F1 alpha and F2 alpha and some anti-inflammatory drugs such as acetylsalicyclic acid, flufenamic acid, indomethacin, and fluocinolone acetonide (FA) on the binding of [3H]7,12-demthylbenz[alpha]anthracene (DMBA) to DNA of murine epidermal cells have been investigated. PG E1 and E2 significantly inhibit the binding of DMBA to murine epidermal cells (MEC) DNA while PG F1 alpha and F2 alpha do not affec the binding. Salicyclic acid and flufenamic acid also do not alter the binding; whereas, indomethacin and FA lowered the binding of DMBA to DNA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism*; D005439:Flufenamic Acid / Q000494:pharmacology; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D001551:Benz(a)Anthracenes; D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D005446:Fluocinolone Acetonide; D015127:9,10-Dimethyl-1,2-benzanthracene; D005439:Flufenamic Acid; D004247:DNA; D001241:Aspirin; D007213:Indomethacin