title: Genetic instability in Drosophila melanogaster: tandem duplications as monitors of intrastrand exchange.
abstract: Two tandem duplications of the X chromosome associated with the white eye color locus are described. In heterozygous females both revert to a nonduplicated chromosome without detectable meiotic recombination. Clustering of revertants suggests the reversion event occurs in the germ line prior to meiosis. Similarly in males one duplication also reverts with clustering implying a premeiotic event. Revertant X chromosomes derived from males are either nonduplicated or deleted. Intrastrand exchange can account for some but not all revertants recovered.
mesh_terms: D000818:Animals; D004261:DNA Replication; D004331:Drosophila melanogaster / Q000235:genetics*; D005127:Eye Color; D005260:Female; D005796:Genes; D005804:Genes, Lethal; D008040:Genetic Linkage; D008297:Male; D008540:Meiosis; D011995:Recombination, Genetic; D014960:X Chromosome