[Effect of polychlorinated biphenyls in the rat. III - PCB distribution, storage and elimination relation time (author's transl)].
The study of accumulation and elimination of Phenoclor DP6 (a commercial PCB mixture) was carried out in three experiments : 1) Rats were fed diet containing 100 ppm of DP6 and were sacrificed after 1, 3, 8, 15 and 30 days. 2) Rats fed DP6 diet during 15 days were subsequently fed with a control diet and sacrificed 8, 15, 52 and 78 days after removal DP6 diet. 3) Bile was collected from surgically treated rats fed DP6 diet during 15 days. Polychlorobiphenyls were spotted in fat carcasses, liver, brain, kidney, muscle, feces and urine to determine absorption, distribution in the animal organism and the clearence rates in urine and feces. We found a very hight DP6 absorption and retention. The low excretion and metabolisation of DP6 result in low decrease after removal DP6 diet.
D000818:Animals; D001646:Bile / Q000378:metabolism; D004032:Diet; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D011078:Polychlorinated Biphenyls
Intoxication alimentaire par les polychlorobiphényles (PCB) chez le rat. III - Distribution, stockage et élimination des PCB en fonction du temps.