[Chemical reactivity and biological properties of a series of aminochlorambucil derivatives].
The substitution of aminochlorambucil by a methyl group increased the chemical reactivity in IV b (n = 1) and IV b (n = 2) but their cytotoxicity remained low. The immunosuppressive effect (adjuvant arthritis in Rats and tuberculin related skin reaction) was observed with IV b (n = 2). Aminochlorambucil was effective on adjuvant arthritis only and IV b (n = 1) had no activity. Aminochlorambucil, IV b (n = 1) and IV b (n = 2) were devoid of any non-specific anti-inflammatory activity.
D000818:Animals; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001169:Arthritis, Experimental / Q000188:drug therapy; D002699:Chlorambucil / Q000031:analogs & derivatives* / Q000494:pharmacology; D007166:Immunosuppressive Agents; D008297:Male; D051381:Rats; D014374:Tuberculin Test
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D002699:Chlorambucil
Réactivité chimique et propriétés biologiques dans la série de l'aminochlorambucil.