[Effect of combined administration of hydrocortisone and EDTA on the number of the antibody-producing cells in the spleen of mice immunized with sheep erythrocytes].
Experiments on mouse hybrids (CBA X C57BL)F1I indicated that injection of hydrocortisone in a dose of 1 mg/mouse 24 hours after the immunization with sheep red blood cells against the background of multiple EDTA injection resulted in a relative reduction of the plaque-forming cells in the spleen--more than 6-fold in comparison with control, and more than 3-fold in comparison with the effect of hydrocortisone or EDTA alone. This may possibly be the consequence of a more intensive hydrocortisone incorporation under conditions of prolonged hypocalciemic action of EDTA complexon.
D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology* / Q000187:drug effects; D002452:Cell Count / Q000187:drug effects; D004492:Edetic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000494:pharmacology; D007114:Immunization; D051379:Mice; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology*
D004492:Edetic Acid; D006854:Hydrocortisone
Vliianie sovmestnogo vvedeniia gidrokortizona i EDTA ns kolichestvo antiteloobrazuiushchikh kletok v selezenke mysheĭ, immunizirovannykh eritrotsitami barana.