Effect of dehydration on erythropoiesis in mice: relevance to the "anemia" of space flight.
Mice deprived of water for 24 h showed an increase in hematocrit and loss of body weight comparable to that seen in men during space flight. The increase in hematocrit was entirely due to a decrease in plasma volume and was associated with suppression of erythropoiesis, but with no significant change in the serum titer of a presumptive humoral regulator of erythropoiesis, Erythroid Stimulating Activity (ESA). Mice deprived of water for 24 h may be a useful model for the study of the early hematological effects of space flight. The suppression of erythropoiesis due to a relative erythrocytosis appears to be independent of ESA.
D000818:Animals; D003681:Dehydration / Q000503:physiopathology*; D004920:Erythropoiesis; D005260:Female; D000882:Haplorhini; D006400:Hematocrit; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D013026:Space Flight; D014868:Water Deprivation