Neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex.
When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001921:Brain / Q000196:embryology / Q000254:growth & development; D001931:Brain Mapping; D002454:Cell Differentiation; D002540:Cerebral Cortex / Q000166:cytology*; D000882:Haplorhini; D008253:Macaca mulatta; D009434:Neural Pathways / Q000166:cytology*; D013569:Synapses / Q000648:ultrastructure*