title: trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound.
abstract: The synthesis and antiallergic activity of a new heterocyclid steroidal molecule are described. Compound 1 was shown to inhibit the rat passive cutaneous anaphylaxis and its activity in this system was compared to that of disodium cromoglycate. It is orally active at a dose of 35 mg/kg (ED50) and its activity persists for up to 6 h for larger doses.
mesh_terms: D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D006633:Histamine Antagonists; D011720:Pyrazoles; D004205:Cromolyn Sodium