Extrapancreatic action of sulphonylureas: effect of gliquidone on insulin and glucagon binding to rat liver plasma membranes.
Gliquidone (a second generation sulphonylurea) was administered orally to normal rats 1 h before killing. Gliquidone treatment led to a decrease in plasma glucose, an increase in insulin and a diminution in glucagon concentration. Insulin binding to liver plasma membranes was enhanced by 40% in comparison with controls, whereas glucagon binding was slightly diminished. These findings indicate a greater sensitivity of liver cells to insulin during sulphonylurea treatment and support the view that sulphonylureas potentiate insulin action on the liver.
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000494:pharmacology*
D007328:Insulin; D013453:Sulfonylurea Compounds; D005934:Glucagon; C010969:gliquidone