Liver injury following administration of 8-methoxypsoralen during PUVA therapy.
A case of liver injury caused by 8-methoxypsoralen given orally during PUVA therapy is presented. The reaction, manifested by elevated serum alanine-aminotransferase and serum aspartate-aminotransferase, was provoked on three consecutive occasions, on the last one with 8-MOP only. The liver injury seems to be of the hepatocellular and nonpredictable type.
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000201:enzymology; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008730:Methoxsalen / Q000009:adverse effects*; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008730:Methoxsalen