Juvenile chronic myelogenous leukemia and dermal histiocytosis. In Von Recklinghausen's disease.
A 4-year-old boy with multiple café-au-lait spots and a family history of neurofibromatosis had generalized edema, histiocytic rash characterized by benign histiocytic infiltration, hepatomegaly, and life-threatening infection. Six months later, progessive splenomegaly led to juvenile chronic myelocytic leukemia that eventually proved fata. The case represents an important association of diseases.
D001424:Bacterial Infections / Q000150:complications; D002675:Child, Preschool; D006529:Hepatomegaly / Q000150:complications; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008206:Lymphatic Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology