Effect of a lipid load on blood and urinary carnitine in man.
Blood and urine carnitine contents have been determined in patients before and after a lipid load and in patients on haemodialysis. Oral and intravenous lipid administration significantly depressed blood carnitine content and after 500 ml intravenous Intralipid urinary carnitine excretion fell by 43%. Blood carnitine was reduced by 50% by haemodialysis and returned to the pre-dialysis value within 20 h in 5 out of 8 patients. It is concluded that the blood carnitine level is normally controlled over a narrow range. The fall in blood carnitine concentration and urine excretion which follows a lipid load indicate a limiting role for carnitine in lipid utilization in man, and suggest that carnitine supplements could be of value during parenteral nutrition with fats.
D000284:Administration, Oral; D002331:Carnitine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004041:Dietary Fats / Q000008:administration & dosage; D005223:Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000652:urine; D008286:Malabsorption Syndromes / Q000097:blood / Q000652:urine; D010288:Parenteral Nutrition; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology; D011247:Pregnancy; D006435:Renal Dialysis; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology
D004041:Dietary Fats; D005223:Fats; D005227:Fatty Acids; D010713:Phosphatidylcholines; D014280:Triglycerides; D005990:Glycerol; D002331:Carnitine