title: Measurement of multiple simultaneous small dimensions and study of arterial pressure-dimension relations in conscious animals.
abstract: This paper describes the development of several important modifications that were incorporated into the ultrasonic, transit-time dimension system in order to obtain multiple simultaneous, instantaneous, and continuous measurements of the external dimensions of the aorta and its major branches in conscious, unrestrained animals. At operation a pair of small piezoelectric crystals was sutured to arterial adventitia, and a miniature pressure gauge was implanted in the vessel at the same cross-sectional plane. After recovery from surgery, wall motion was not altered appreciably and scarring was minimal. This technique allows long-term monitoring of aortic pressure-dimension relations and is applicable for small (fetal and neonatal) as well as large (adult dogs and sheep) animals. When vessel wall thickness is measured, stress-radius analysis can be performed so as to compute vascular elastic stiffness as a function of stress. Moreover, the suitability for radiotelemetry of the pressure and dimension signals measured with this technique enables the study of these parameters in unrestrained animals, e.g., during spontaneous severe exercise.
mesh_terms: D000809:Angiotensins / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000502:physiology; D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology; D012756:Sheep; D013686:Telemetry / Q000295:instrumentation; D014463:Ultrasonography
chemical_list: D000809:Angiotensins; D005996:Nitroglycerin