Genetic and cytogenetic studies of the malate dehydrogenases of Drosophila melanogaster.
Genetic and cytogenetic locations of the structural genes for the NAD-dependent malate dehydrogenases have been studied. The mitochondrial form (mMDH) is coded for by a gene (mMdh) found at 62.6 on the third chromosome and included in Df(3R)R14, which includes 90C2-91A3 in the salivary gland chromosomes. Based on its inclusion within several J (Jammed; 2-41.0) deficiencies, the structural gene (cMdh) for the cytoplasmic form (cMDH) was determined to lie in region 31B-E, confirming the earlier finding of Grell. Flies lacking any cMDH activity (cMdhn-gamma 10069/Df(2L)J-der-27) were both viable and fertile.
D000818:Animals; D002874:Chromosome Mapping; D003593:Cytoplasm / Q000201:enzymology; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D007527:Isoenzymes / Q000235:genetics*; D008291:Malate Dehydrogenase / Q000235:genetics*; D008928:Mitochondria / Q000201:enzymology; D011995:Recombination, Genetic
D007527:Isoenzymes; D008291:Malate Dehydrogenase