Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice.
In mice poisoned by alpha-amanitin nuclear changes typical of this toxin were observed in beta-cells of pancreatic islets. The lesions became progressively more severe and at 48 h after toxin injection some cells were necrotic. The damage to these cells could have implications in the changes in glycogen metabolism which occur after alpha-aminitin poisoning.
D000546:Amanitins / Q000494:pharmacology* / Q000506:poisoning; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D006003:Glycogen / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009336:Necrosis
D000546:Amanitins; D006003:Glycogen