Effect of diet on the metabolism and toxicology of drugs.
The human organism is continuously exposed to a variety of xenobiotics, as drugs, pesticides, food additives and many environmental contaminants, all of which are potentially toxic. The body metabolizes these highly reactive chemicals to pharmacologically-inert compounds, which are readily eliminated from the body. This process of deactivation is dependent on nutritional status. Malnutrition, almost invariably, leads to a reduced capacity to deactivate these exogenous materials with consequent increase in toxicity.
D000818:Animals; D001206:Ascorbic Acid Deficiency / Q000150:complications; D001361:Avitaminosis / Q000150:complications; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism; D002648:Child; D004785:Environmental Pollutants / Q000378:metabolism; D005503:Food Additives / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D008055:Lipids / Q000172:deficiency; D051379:Mice; D008903:Minerals / Q000172:deficiency; D006899:Mixed Function Oxygenases / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000150:complications; D051381:Rats; D014116:Toxicology
D002273:Carcinogens; D004785:Environmental Pollutants; D005503:Food Additives; D008055:Lipids; D008903:Minerals; D004364:Pharmaceutical Preparations; D006899:Mixed Function Oxygenases