[Isolation of the islands of Langerhans and their transplantation under experimental conditions].
Isolated islets of Langerhans were obtained from sexually immature rats by means of collagenase. Interperitoneal isotransplantation of the islets to rats with alloxan diabetes caused an improvement of their condition, normoglycemia, and elevation of the immunoreactive insulin level, and prolonged survival of these rats, in the presence of coarse morphological changes in the endocrine part of the pancreas of the recipient (in 2--4 weeks). It is suggested that the insular cells of the islets of Langerhans isolated from the immature rats were viable.
D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D005500:Follow-Up Studies; D016381:Islets of Langerhans Transplantation; D051381:Rats; D014020:Tissue Extracts / Q000302:isolation & purification; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D014020:Tissue Extracts; D000496:Alloxan
Izoliatsiia ostrovkov Langergansa i ikh transplantatsiia v eksperimente.