The in vitro metabolism of progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one by fetal rhesus monkey testes.
Homogenates prepared from fetal rhesus monkey testes were incubated with progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one. The major progesterone metabolite was 17-hydroxy-4-pregnene-3,20-dione. Testosterone also accumulated in the progesterone incubations. 4-Androstene-3,17-dione was converted chiefly to testosterone. Testosterone was not actively metabolized by the fetal monkey testis. 17 beta-Hydroxy-5 alpha-androstan-3-one was actively converted primarily to 5 alpha-androstane-3 beta,17 beta-diol.
D000735:Androstenedione / Q000378:metabolism*; D000818:Animals; D002855:Chromatography, Thin Layer; D013196:Dihydrotestosterone / Q000378:metabolism*; D005260:Female; D005333:Fetus; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium
D013196:Dihydrotestosterone; D014316:Tritium; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone