[Regional variations and particle binding of free amino acids in the rat brain: effects of amphetamine and methaqualone].
Amphetamine and methaqualone affected aspartate level in various regions of Rat brain. Increased aspartate level in cerebral cortex of methaqualone treated Rats was produced in the aspartate fraction whose binding to subcellular particules was Na+ dependant. This work suggest that aspartate level was altered only in brain fraction implicated in the pharmacological effects of the drugs.
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D005260:Female; D008702:Methaqualone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D051381:Rats
D000596:Amino Acids; D001224:Aspartic Acid; D008702:Methaqualone; D000661:Amphetamine; D000409:Alanine
Variations régionales et liaisons particulaires des amino-acides libres dans le cerveau de Rat: effets de l'amphétamine et de la méthaqualone.