[Tissue concentrations of sulfametrol-trimethoprim in the human prostate (author's transl)].
Ten patients with normal liver and kidney functions were admitted to a urology department for prostatectomy because of benign prostatic hypertrophy. They received a twice daily administration of 2 tablets of sulfametrole/trimethoprim (Lidaprim) for 4 days; the last dose of 2 tablets was given 4 hours before surgery. Having been enucleated by the suprapubic route, the prostatic glands were examined both histologically and chemico-analytically. The concentrations of the chemotherapeutically active substances were determined in the plasma and in the prostatic tissues. The prostatic tissue concentration of sulfametrole was 24,0 +/- 8,6 mg/kg and that of trimethoprim 7,1 +/- 2,2 mg/kg.
D000368:Aged; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011467:Prostate / Q000378:metabolism*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000601:surgery*; D013424:Sulfanilamides / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D013607:Tablets; D014295:Trimethoprim / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D004338:Drug Combinations; D013424:Sulfanilamides; D013607:Tablets; D014295:Trimethoprim
Zur Bestimmung der Gewebskonzentration von Sulfametrol-Trimethoprim in der menschlichen Prostata.