Drug-induced lupus erythematosus aggravated by oral zinc therapy.
A woman with hypertension had been treated with hydralazine and propranolol for the past 6 years. Leg ulcers and mild joint involvement had been observed for 3 years. When oral zinc therapy was started, multisystemic manifestations of a lupus erythematosus-like syndrome developed within one week. The possible implication of zinc in drug-induced lupus is discussed.
D000284:Administration, Oral; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D015032:Zinc / Q000008:administration & dosage / Q000009:adverse effects*
D015032:Zinc