title: L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT): A probe for regulatory mechanisms in antibody responses.
abstract: The synthetic random terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) has been used as a probe to investigate regulatory mechanisms in antibody responses in tissue culture systems. In this brief review, the mechanisms of H-2 linked Ir gene control of antibody responses to GAT and genetic restrictions governing Mphi-immune T cell interactions in antibody responses to GAT are summarized.
mesh_terms: D000409:Alanine; D000818:Animals; D000917:Antibody Formation; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D005971:Glutamates; D006183:H-2 Antigens / Q000235:genetics; D007165:Immunosuppression Therapy; D008211:Lymphocyte Cooperation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014443:Tyrosine
chemical_list: D005971:Glutamates; D006183:H-2 Antigens; D010455:Peptides; D014443:Tyrosine; D000409:Alanine