Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.
The production of osteoclast-activating factor (OAF) by normal human peripheral blood leukocytes stimulated by phytohemagglutinin was inhibited by a series of structurally unrelated inhibitors of prostaglandin synthetase. Inhibition of OAF production by these agents was reversed by adding prostaglandins of the E series back to the leukocyte suspension. These results indicate that prostaglandin synthesis is necessary for OAF production.
D001862:Bone Resorption / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D005439:Flufenamic Acid / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis*; D010010:Osteoclasts / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D008222:Lymphokines; D010835:Phytohemagglutinins; D011458:Prostaglandins E; D005439:Flufenamic Acid; D007213:Indomethacin