Effect of gastrointestinal hormone infusions of lower oesophageal competence of rhesus monkeys.
The lower oesophageal high pressure zone (HPZ) was studied in 5 non-refluxing and 3 refluxing Rhesus monkeys. The changes in HPZ and reflux status in response to infusion of various doses of secretin, cholecystokinin and glucagon were measured in all animals, and, in the 5 non-refluxing monkeys, after oesophagogastrectomy with replacement of the lower oesophagus by a stomach tube. All three hormones consistently produced a transient decrease in the HPZ pressure. The only change in response following oesophagagastrectomy and gastric tube replacement was a significant delay in the response to each hormone. Neither hormone infusion nor operation altered gastro-oesophageal reflux status. It appears that lower oesophageal competence in primates is more dependent on the presence of narrow, muscular, intra-abdominal tube than on a specialized segment of the lower oesophagus.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004943:Esophagogastric Junction / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D004947:Esophagus / Q000601:surgery; D005743:Gastrectomy; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D005934:Glucagon / Q000494:pharmacology*; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D011312:Pressure; D012633:Secretin / Q000494:pharmacology*; D013997:Time Factors
D012633:Secretin; D005934:Glucagon; D002766:Cholecystokinin