Does gastrin (pentagastrin) act directly on the parietal cell in the isolated whole stomach of the mouse?
Acid secretory effect of pentagastrin and compound 48/80 was studied in the isolated whole stomach of the mouse. Acid secretory response to compound 48/80 was inhibited by cimetidine, indicating histamine involvement in this reaction. Acid secretion stimulated by pentagastrin was not diminished after pre-treatment with compound 48/80 suggesting that gastrin releases non-mast cell histamine. Secretory response to pentagastrin was reduced in Ca++-free serosal media but not to histamine and compound 48/80. A possible pathway of gastrin will be discussed.
D006631:Amine Oxidase (Copper-Containing) / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D008297:Male; D051379:Mice; D010418:Pentagastrin / Q000494:pharmacology*; D013270:Stomach / Q000166:cytology / Q000187:drug effects*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine; D002927:Cimetidine; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D010418:Pentagastrin; D002118:Calcium