Lung lecithin synthesis in primates as related to respiratory distress syndrome.
Lecithin is synthesized de novo in the lung by two biochemical pathways, choline incorporation and phosphatidylethanolamine methylation. These studies in the Macaca mulatta fetus and neonate have demonstrated the relative contributions of the two pathways and the timing in monkey gestation of increased pulmonary lecithin production.
D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D002794:Choline / Q000378:metabolism; D004983:Ethanolamines / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D000882:Haplorhini; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008168:Lung / Q000378:metabolism*; D008251:Macaca / Q000378:metabolism*; D008253:Macaca mulatta / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology*; D013109:Sphingomyelins / Q000096:biosynthesis
D004983:Ethanolamines; D010713:Phosphatidylcholines; D013109:Sphingomyelins; D002794:Choline