[Preventive action of phenylalanine on acute intoxication of ochratoxin-A].
Ochratoxin-A, a mycotoxin causing kidney and liver damage, inhibits protein synthesis by competition with phenylalanine in the phenylalanyl-tRNA synthetase catalysed reaction. A dose of 0,8 mg ochratoxine per Mouse is 100% lethal within 24 hrs, when injected intraperitoneally. When phenylalanine is injected simultaneously with ochratoxine-A, the survival of the animals was 100% for 1 mg of phenylalanine per Mouse. Ten times higher doses of phenylalanine are necessary to obtain a 85% survival if the amino acid is injected 30 min. after the mycotoxin. Phenylalanine gives a very low protection if injected 1 hr or more ochratoxine-A.
D000818:Animals; D003967:Diarrhea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D051379:Mice; D009793:Ochratoxins / Q000633:toxicity*; D010649:Phenylalanine / Q000494:pharmacology*
D009793:Ochratoxins; C025589:ochratoxin A; D010649:Phenylalanine
Action préventive de la phenylalanine sur l'intoxication aiguë par l'ochratoxine-A.