Assignment of structural beta-galactosidase loci to human chromosomes 3 and 22.
Hybrid cell lines isolated after fusions between Chinese hamster E36 cells and normal human white blood cells were analyzed for human beta-galactosidase isoenzymes and for human chromosomes, especially 3, 12, and 22, the candidates for bearing a beta-galactosidase locus. Results of neuraminidase treatment of the cell lysates and immunological studies showed that in man two structural beta-galactosidase loci are present and can be assigned to chromosomes 3 and 22. No correlation was found between the expression of human beta-galactosidase and the presence of human chromosome 12.
D000818:Animals; D002460:Cell Line; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D006224:Cricetinae; D005696:Galactosidases / Q000096:biosynthesis*; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D001616:beta-Galactosidase / Q000096:biosynthesis*
D005696:Galactosidases; D001616:beta-Galactosidase