The gastric antisecretory activity of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide).
3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide) possesses potent gastric antisecretory activity in a number of animal species. It causes a marked inhibition in the volume and concentration of basal and chemically-stimulated gastric acid secretion in the conscious rat and guinea-pig, and of chemically-stimulated secretion in the anaesthetised cat, dog and monkey. Marked activity is also seen in conscious Heidenhain-pouch dogs, against secretion stimulated by betazole and gastrin tetrapeptide. In the pylorus-ligated rat preparation, the antisecretory effect of 30 mg/kg tiquinamide persists for 8-9 h. The possible mode of action of this drug, in view of its wide non-selective antisecretory profile, is discussed.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005765:Gastrointestinal Agents; D006168:Guinea Pigs; D000882:Haplorhini; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D005765:Gastrointestinal Agents; D006632:Histamine; D002217:Carbachol; D010434:Pepsin A; D010418:Pentagastrin