Heterogeneity of sickle cell anaemia in Arabs: review of cases with various amounts of fetal haemoglobin.
A study is presented on eleven patients with homozygous sickle cell anaemia. They are non-Sheeah Arabs from the United Arab Emirates on the south-eastern coast of the Arabian Peninsula. The proportions of fetal haemoglobin in these patients are variable, and there is a marked variation in the severity of their disease condition; these facts are not related. African sickle cell gene admixture is a likely affecting factor.
D000755:Anemia, Sickle Cell / Q000097:blood* / Q000235:genetics; D005319:Fetal Hemoglobin / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics; D006443:Hemoglobin A2 / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D014479:United Arab Emirates
D006451:Hemoglobin, Sickle; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin