The induction and transplantation of hepatomas in Wistar and BD IX rats.
Hepatomas were induced by feeding rats laboratory chow containing 0,6375 g of 3'-methyl-4-dimethylaminoazobenzene per kg for 3 to 5 months. DAB-1 was a hepatoma induced in randomly bred Wistar rats and was transplanted for 3 years after which it failed to grow in vivo but not in vitro. DAB-2 and DAB-3 are new transplantable hepatoma lines established in highly inbred DBIX rats. DAB-3 has a metaplastic morphology showing, inter alia, goblet cells, cartilagenous areas, duct-like structures and glandular follicles. This is unlike DAB-1 and DAB-2 which showed poorly differentiated trabecular or anaplastic carcinomatous patterns.
D000818:Animals; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D009368:Neoplasm Transplantation / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains; D004124:p-Dimethylaminoazobenzene
D004124:p-Dimethylaminoazobenzene