Endothelium-associated IgG in the post-capillary venules of the lymphatic tissues in mice bearing experimental neoplasia.
Post-capillary venules (PVC) of the lymph nodes and Peyer's patches were studied in frozen sections stained with an indirect immunoperoxidase technique to demonstrate their endothelium-associated IgG in DBA/2 mice bearing mastocytoma. The previously established three types of IgG-distribution (luminal, intraendothelial and basement membrane site), each confined to one of the three PCV grades (graded on the basis of the endothelial cell height), were found in these tumor-bearing mice, too. This finding shows that the tool applied in T-lymphocyte deprivation, be it a tumor or anti-theta-globulin, does not influence the behavior of this IgG-distribution profile. This fact lends further support to the thesis that the endothelium-associated IgG could be involved in the regulation of the T-cell passage through the wall of the post-capillary venules.
D000818:Animals; D004727:Endothelium / Q000276:immunology; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis*; D008198:Lymph Nodes / Q000276:immunology / Q000648:ultrastructure*; D008212:Lymphocyte Depletion; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000648:ultrastructure; D010581:Peyer's Patches / Q000276:immunology; D014680:Veins / Q000276:immunology*; D014699:Venules / Q000276:immunology*
D007074:Immunoglobulin G