[In vitro antibacterial activity of a halogenated derivative of D-alanine].
The "in vitro" effect of beta-chloro-D-alanine, a drug that inhibits cell-wall synthesis, was studied. We used some strains of microorganisms, mainly Gram-negative and resistant to antibiotics with the same mechanism of action. MIC and MBC values obtained show a poor efficacy of this drug. Therefore we studied the association of beta-chloro-D-alanine with ampicillin and fosfomycin. The evaluation of the results, determined by means of a graphic and a mathematical method, shows a good synergistic effect with both associations. Synergism is more marked with ampicillin.
D000409:Alanine / Q000031:analogs & derivatives*; D000667:Ampicillin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology
D015091:beta-Alanine; D005578:Fosfomycin; C006977:3-chloroalanine; D000667:Ampicillin; D000409:Alanine
Attivita' antibatterica in vitro di un derivato alogenato della D-alanina.