title: Isoprinosine increases the antitumor action of interferon.
abstract: The association of relatively low doses of interferon with an immunostimulant, isoprinosine, enhanced the antitumor effect of interferon. Each mouse was inoculated with 10(6) Crocker Tumor 180/TG cells. The best results were obtained when both interferon and isoprinosine were injected three times a week for 1 month. Under these conditions, the mean survival time increased from 26 days in the controls to 45 days in the interferon-treated group to 64 days when both agents were used. Isoprinosine alone had no effect. The final survival rate increased from 1 mouse out of 50 mice in the control group to 10 mice out of 50 in the interferon-treated groups and to 25 mice out of 50 with the combined treatment.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D004357:Drug Synergism; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D007288:Inosine; D007372:Interferons; D007542:Inosine Pranobex