[A contribution to the stabilisation of the MVA-vaccine (author's transl)].
The titre of the MVA-vaccine remains constant at -20 degrees C with human serum albumin, sorbitol, Haemaccel, Rheomacrodex and cysteine within 8 month. At -20 degrees C the stability of the MVA-virus is equivalent to the Vaccinia-virus, stabilized by peptone and sorbitol. Storing the MVA-Virus at +4 degrees C, +20 degrees C for 8 month or at 27 degrees C for 4 weeks, 1% human serum albumin and 5% sorbitol preserves the virustitre best, but the stability of Vaccinia-virus with 5% peptone and 5% sorbitol can, however, not be obtained by the MVA-virus under these conditions.
D000818:Animals; D002642:Chick Embryo; D003545:Cysteine; D003911:Dextrans; D004355:Drug Stability; D005321:Extraembryonic Membranes / Q000382:microbiology; D005612:Freeze Drying; D010461:Peptones; D011097:Polygeline; D012709:Serum Albumin; D012900:Smallpox Vaccine / Q000276:immunology*; D013012:Sorbitol; D014616:Vaccinia virus / Q000276:immunology* / Q000302:isolation & purification; D014776:Virus Cultivation
D003911:Dextrans; D010461:Peptones; D012709:Serum Albumin; D012900:Smallpox Vaccine; D013012:Sorbitol; D011097:Polygeline; D003545:Cysteine
Ein Beitrag zur Stabilisierung des MVA-Impfstoffs.