title: Regulation of the immune response by macrophages.
abstract: Regulation of the immune response by macrophages was studied with cellular resistance to Listeria monocytogenes as parameter. The use of agents which suppress macrophage activity during the induction-phase of immunity enabled the induction of protective immunity with killed listeria. Fractionation of the cell content of listeria yielded an RNA'se sensitive fraction which in a dose of 300 ng and in combination with the cationic surfactant dimethyl dioctadecyl ammonium bromide induced protective immunity against listeria.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D003911:Dextrans / Q000276:immunology; D006358:Hot Temperature; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology / Q000517:prevention & control; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013498:Suramin / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D003911:Dextrans; D000644:Quaternary Ammonium Compounds; C015831:dimethyldioctadecylammonium; D013498:Suramin