Polyadenylate-polyuridylate enhancement of 7,12-dimethylbenz-anthracene skin carcinogenesis.
Double-stranded polynucleotide polyadenylate-polyuridylate (Poly AU) enhanced skin tumor formation in Swiss mice by 75% when injected prior to a single application of 7,12-dimethylbenzanthracene (DMBA). When given after the carcinogen application Poly AU did not significantly enhance tumor formation.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology; D011063:Poly A-U / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000503:physiopathology*
D011063:Poly A-U; D015127:9,10-Dimethyl-1,2-benzanthracene