M components and cancer.
Intention of this study was to prove or exclude in patients with different neoplasms some M components which can escape routine electrophoretic analysis or immunoelectrophoretic analysis with polyvalent antiserum. All serum samples from 606 patients were investigated also with monospecific antisera against heavy chains--alpha, gamma, mu and delta--and in suspicion of abnormality also with antisera against light chains. Patterns similar to those found in cases of heavy chain diseases were absent in all patients. M components of IgD class were not found, as well. As to M components of usual types a relatively high incidence was found in lymphoproliferative malignancies excluded myelomas or Waldenstroöm's macroglobulinemias (5.61% in adults and 2.32% in children). On the basis of results the importance of immunoelectrophoretical analysis with monospecific antisera in all these cases is pointed out; not only in attempt to discover additional subjects of heavy chain diseases but also to detect mild "macroglobulinemic" abnormalities which may not be so far detected on electrophoretical pattern.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D007223:Infant; D007938:Leukemia / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology; D010266:Paraproteins / Q000378:metabolism*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D010266:Paraproteins