Beneficial effects of colchicine in experimental nephrotoxic serum nephritis in the rat.
Glomerulonephritis was induced in rats by multiple injections of rabbit anti-rat kidney serum. Colchicine was administered daily for 4 months to nephrotoxic serum treated rats and untreated control animals. Nephritic rats receiving colchicine had significantly less proteinuria and less glomerular damage than unprotected nephritis animals. A possible role for colchicine in the early treatment of human glomerulonephritis is suggested.
D000818:Animals; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000276:immunology; D007106:Immune Sera; D007678:Kidney Glomerulus / Q000276:immunology; D051381:Rats
D007106:Immune Sera; D003078:Colchicine