Drug therapy reviews: pharmacotherapy of diarrhea.
Gastrointestinal physiology, and the pathophysiology, diagnosis, symptoms and treatment of acute and chronic diarrhea are reviewed. Drugs used in the treatment of diarrhea include opiates (morphine, codeine), synthetic anti-diarrheals (diphenoxylate, loperamide), anticholinergics (atropine, propantheline), adsorbents (kaolin, pectin, cholestyramine resin) and Lactobacillus acidophilus. Chronic diarrhea and acute diarrhea caused by microorgansims, drugs and viruses are described. The management of diarrhea can be divided into three categories: (1) supportive therapy (fluid and electrolyte replacement); (2) symptomatic therapy which improves the consistency of the stool and reduces the frequency of bowel movements; and (3) specific therapy aimed at treating the cause (e.g., antibiotics for bacteria-induced diarrhea) or blocking the cellular mechanisms of fluid and electrolyte loss. Most acute diarrheal conditions can be managed successfully by avoiding oral solids and ingesting carbohydrate-electrolyte solutions. Synthetic antidiarrheals may increase the toxicity associated with bacterial diahhrea.
D000327:Adsorption; D000562:Amebiasis / Q000150:complications; D000930:Antidiarrheals / Q000627:therapeutic use; D002771:Cholera / Q000150:complications; D003967:Diarrhea / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004064:Digestive System / Q000378:metabolism; D004068:Digestive System Physiological Phenomena; D004405:Dysentery, Bacillary / Q000150:complications; D005873:Giardiasis / Q000150:complications; D006801:Humans; D007779:Lactobacillus acidophilus; D009892:Opium / Q000031:analogs & derivatives / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use; D012480:Salmonella Infections / Q000150:complications; D014195:Travel; D014777:Virus Diseases / Q000150:complications
D000930:Antidiarrheals; D010276:Parasympatholytics; D009892:Opium