Studies on 3-methylhistidine metabolism in children with protein-energy malnutrition.
Twenty-four hour urinary excretion of 3-methylhistidine (3-MeHis) was determined in children suffering from severe and moderate degrees of protein-energy malnutrition before and after treatment. Excretion of 3-MeHis was decreased both in children with severe protein-energy malnutrition and during undernutrition and increased considerably after treatment. The results suggest that there is a quantitative as well as a qualitative change in 3-MeHis metabolism in protein-energy malnutrition. A sensitive index for studying muscle protein metabolism is not available so far. Studies reported herein seem to suggest that 3-MeHis may fulfill such a requirement.
D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004044:Dietary Proteins / Q000627:therapeutic use; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D007223:Infant; D008762:Methylhistidines / Q000652:urine*; D009124:Muscle Proteins / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000178:diet therapy / Q000378:metabolism*
D004044:Dietary Proteins; D008762:Methylhistidines; D009124:Muscle Proteins; D006639:Histidine; D003404:Creatinine