Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D003510:Cyclohexanes / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D066298:In Vitro Techniques; D008748:Methylcholanthrene / Q000494:pharmacology; D008797:Metyrapone / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D011078:Polychlorinated Biphenyls / Q000494:pharmacology; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D013045:Species Specificity
D001580:Benzopyrenes; D003510:Cyclohexanes; D004791:Enzyme Inhibitors; D005419:Flavonoids; D000072317:Polychlorinated Dibenzodioxins; D011285:Pregnenolone Carbonitrile; D000431:Ethanol; D008748:Methylcholanthrene; D004247:DNA; D011078:Polychlorinated Biphenyls; D010634:Phenobarbital; D008797:Metyrapone