[Conformational coupling between structural units. A decisive step in the functional structure formation].
Proteins built up of several structural domains are compared with oligomeric proteins made up of several subunits. On this basis the functional consequences of a conformational coupling between domains are analyzed. From the data obtained on the elastase molecule it is proposed that the last step in protein folding insures the optimal coupling between domains and the energy of interaction is utilized for catalysis.
D002384:Catalysis; D004798:Enzymes / Q000378:metabolism; D010446:Peptide Fragments; D014176:Protein Biosynthesis; D011487:Protein Conformation; D013816:Thermodynamics
D004798:Enzymes; D010446:Peptide Fragments
Couplage conformationnel entre unités structurales. Etape décisive dans la formation de la structure fonctionnelle des protéines.