title: Chemical occlusion of rhesus monkey oviducts with chloroquine.
abstract: Fertility control through chemical occlusion of the oviducts with chloroquine was investigated in rhesus monkeys (M.m.). Chloroquine was instilled retrograde through the tubal ostium after laparotomising the monkeys as a 10, 50 and 100% suspension (w/v) in aqueous carboxymethyl cellulose (CMC) solution which was used as a carrier vehicle. Complete occlusion of the Fallopian tubes at the uterotubal junction and also the intramural portions resulted in 15 days after a single instillation.
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D010057:Oviducts / Q000187:drug effects* / Q000473:pathology
chemical_list: D002738:Chloroquine