Generalization study with some narcotic and nonnarcotic drugs in rats trained for morphine-saline discrimination.
Rats were trained to lever-press on an FR-10 schedule for food reinforcement, and to respond differentially on two levers while discriminating the effects of morphine (10 mg/kg) injection from those of saline (1 ml/kg). Following discrimination training, the morphine stimulus was generalized to propoxyphene, methadone, fentanyl, and sulfentanyl in a dose-dependent manner, and saline was generalized to alcohol, pentobarbital, azaperone, clonidine, naloxone, and p-chloroamphetamine. p-Chloroamphetamine failed to block the morphine stimulus.
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects*; D005793:Generalization, Psychological / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats
D009294:Narcotics; D009020:Morphine