The effect of intravenous heparin infusions on the thyroid stimulating hormone response to thyrotrophin releasing hormone.
1 The TSH response to TRH is suppressed 24 h after the commencement of i.v. heparin infusion in euthyroid subjects, as compared to repeat testing, both after 7 days of continuous i.v. heparin and after 7 days without heparin but while on warfarin. 2 This suggests that the rise in serum free thyroid hormones, which heparin produces, has a 'metabolic effect'. Possible clinical effects of this action must be considered. 3 Heparin has no effect on the radio-immunoassay of TSH.
D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors; D014859:Warfarin / Q000494:pharmacology
D014859:Warfarin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D006493:Heparin