[Nature and origin of hepatocellular hyaline, Mallory bodies].
The current concepts on the nature and origin of alcohol hyaline are analysed. The latter is a sign of acute alcoholic hepatitis and reflects the severity of destructive and inflammatory processes in the organ; it is based on the protein-polysaccharide-phospholipid complex which has three ultrastructural varieties. The pathogenesis of alcohol hyaline is complex. In addition to the metabolic and toxic effect of ethanol, it includes the following stages: (1) inhibition of dissemination of intermediate filaments synthesized by rough reticulum; (2) accumulation of filaments in cisternae of the rough endoplasmic reticulum and formation of fibrillar hyaline; (3) transformation of the fibrillar hyaline into granular one; (4) hepatocyte necrosis. Alcoholic hyaline as an autoantigen induces antibody production followed by the involvement of the immunopathological mechanisms.
D001324:Autoantigens; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology; D003599:Cytoskeleton / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D006818:Hyalin / Q000276:immunology / Q000378:metabolism; D002479:Inclusion Bodies / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D008099:Liver / Q000276:immunology / Q000648:ultrastructure*; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology; D009504:Neutrophils / Q000648:ultrastructure; D013194:Staining and Labeling
D001324:Autoantigens
O prirode i proiskhozhdenii gepatotselliuliarnogo gialina--telets Mallori.