[Studies on cellular protein synthesis in synovial fluid following intraarticular gold administration (author's transl)].
Na-aurothiomalate was applied intraarticularly in the conentration range between 2 and 40 mg to joints of patients with rheumatoid arthritis. Between 2 and 20 mg a constant inhibition of 3H-aminoacids incorporation in proteins was observed. At a dosage of 40 mg of this gold salt a strong inhibition could be detected. In the low concentration range an additional degradation of structurally changed proteins could be the cause of the lower incorporation rate of 3H-aminoacids. From 40 mg on a real inhibition of protein synthesis seems to occur.
D000596:Amino Acids / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D006052:Gold Sodium Thiomalate / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D014176:Protein Biosynthesis; D013582:Synovial Fluid / Q000166:cytology / Q000378:metabolism*; D013997:Time Factors
D000596:Amino Acids; D006052:Gold Sodium Thiomalate
Untersuchungen über die Proteinsynthese der Zellen der Synovialflüssigkeit nach intraartikulärer Goldapplikation.