title: Effect of the pesticides phosalone and lindane on the activity of some dipeptidases and disaccharidases in rat intestinal mucosa.
abstract: The intestinal dipeptidase and disaccharidase activities were investigated in 120 male albino rats of the Wistar strain after administration of 21 mumol.kg-1 body weight phosalone, 14.8 mumol.kg-1 body weight lindane and 10.5 mumol.kg-1 body weight phosalone combined with 7.4 mumol.kg-1 body weight lindane. The dipeptidase activity under the effect of these comparatively low doses of pesticides reveals slightly to moderate changes. The activity of intestinal disaccharidases after a 90-day phosalone and lindane treatment is markedly decreased, particularly that of sucrase. The mechanism of these changes remains unknown.
mesh_terms: D000818:Animals; D004150:Dipeptidases / Q000378:metabolism*; D004186:Disaccharidases / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D009946:Organothiophosphorus Compounds; D051381:Rats
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; C003117:phosalone; D001556:Hexachlorocyclohexane; D004186:Disaccharidases; D004150:Dipeptidases