title: Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum.
abstract: The inhibitory effect of L-lysine on penicillin biosynthesis by Penicillium chrysogenum has been compared in a low-producing strain (Wis. 54-1255) and a high-producing strain (ASP-78). Lysine inhibited total penicillin synthesis to a similar extent in both strains. However, in the high-producing strain the onset of penicillin synthesis occurred even at a high lysine concentration, whereas in the low-producing strain lysine had to be depleted before penicillin production commenced.
mesh_terms: D003470:Culture Media; D008239:Lysine / Q000494:pharmacology*; D010406:Penicillins / Q000096:biosynthesis*; D010407:Penicillium / Q000378:metabolism*; D010408:Penicillium chrysogenum / Q000187:drug effects / Q000378:metabolism*
chemical_list: D003470:Culture Media; D010406:Penicillins; D008239:Lysine