[Electron microscopical and enzyme histochemical investigation of kidney and liver of the albino rat after cytostatic treatment (author's transl)].
Within 5 days following treatment with cytostatics (vincristine, vinblastine, trenimon, 5-fluorouracil) enzyme-histochemical and ultrastructural changes occurred in the kidney and liver of Wistar rats. The enzyme activities were influenzed by cytostatics in different ways. It was found that the activity of some enzymes increased whereas that of others decreased. Kidney and liver showed a different response in their enzymatic behaviour. The cytostatics used did not have the same effect. The histochemical changes following injection of cytostatics in juvenile rats do not agree with those in adult ones. The electronmicroscopic findings reveal marked morphological changes of the kidney and liver cells within the first 5 days following injection of cytostatics. From the 8th day on after administration of cytostatics neither histochemical nor ultrastructural changes as compared with the controlls were found.
D000818:Animals; D005472:Fluorouracil / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D014228:Triaziquone / Q000494:pharmacology*; D014747:Vinblastine / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D014747:Vinblastine; D014228:Triaziquone; D005472:Fluorouracil
Elektronenmikroskopische und enzymhistochemische Untersuchungen der Niere und Leber von Albinoratten nach Cytostatikabehandlung.