[Viral acanthomas and specialized forms of keratinosome "membrane coating granules" (author's transl)].
In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epithelium. The participation of intercellular extruded "wagon-wheel" bodies, MVB and atypical keratinosomes on an irregular baso-apical diffusion-barrier in the epidermis of cases with viral acanthomas has been discussed. On the basis of the relation seen between MVB and the Golgi-apparatus, their transition to partially atypical keratinosomes in cases of viral acanthomas and their "expulsion" into the intercellular space could indicate that in keratinozytes the enzymatically regulated feed-back between the cellular surface and the capability to synthesize is changed by viral agents. The interference appears to manifest itself in the Golgi-apparatus and also appears to be "specified" by the terrain present.
D000818:Animals; D003218:Condylomata Acuminata / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D007633:Keratins / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000648:ultrastructure; D008854:Microscopy, Electron; D010212:Papilloma / Q000648:ultrastructure*; D012871:Skin Diseases / Q000473:pathology; D012878:Skin Neoplasms / Q000648:ultrastructure; D014412:Tumor Virus Infections / Q000648:ultrastructure*; D014860:Warts / Q000473:pathology
D007633:Keratins
Virusacanthome und besondere Formen von Keratinosomen "Membrane Coating Granules".