Amylase secretion in the rabbit parotid gland when stimulating the sympathetic nerves during parasympathetic activity.
1. In anaesthetized rabbits amylase secretion from the parotid gland was investigated. Secretion was evoked by sympathetic nerve stimulation, either alone or superimposed on a parasympathetic background secretion, imitating the resting secretion present in the waking animal.2. Sympathetic nerve stimulation at frequencies below 1 Hz was alone subthreshold for fluid secretion, but could greatly increase the amounts of amylase present in fluid secretion produced by parasympathetic nerve stimulation. The amylase output due to sympathetic nerve stimulation alone at 10 Hz did not exceed that seen in response to a stimulation at 1 Hz superimposed on parasympathetic activity.3. The amylase output in response to superimposed sympathetic stimulation was not influenced by the rate of fluid secretion, which was altered by stimulating the parasympathetic nerves at different frequencies.4. Sympathetically-evoked amylase secretion was abolished after beta(1)-block. The amylase secretion remaining on parasympathetic activation was sparse.5. It is concluded that secretion of amylase in response to sympathetic nerve stimulation requires the presence of a parasympathetic fluid secretion to be washed along the glandular ducts. Parasympathetic activity may also augment the sympathetic effect on amylase secretion.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D004558:Electric Stimulation; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010306:Parotid Gland / Q000378:metabolism*; D011217:Practolol / Q000494:pharmacology; D011817:Rabbits; D012636:Secretory Rate / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology*
D001262:Atenolol; D000681:Amylases; D011217:Practolol