title: Formation of the horny layer in psoriasis--primarily defective or secondarily affected.
abstract: It is our belief that any abnormality in keratinization is secondary to an increased rate of epidermal cell production and decreased transit time and research into the underlying nature of psoriasis should concentrate on the issue of whether the stimulus to increased epidermopoietic activity is dermally or epidermally derived.
mesh_terms: D002455:Cell Division; D002462:Cell Membrane / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004817:Epidermis / Q000648:ultrastructure*; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000648:ultrastructure; D011565:Psoriasis / Q000473:pathology*; D012867:Skin / Q000648:ultrastructure*
chemical_list: D007633:Keratins