[Structure-activity relationship of various ephedrine isomers on noradrenaline uptake by the isolated perfused rabbit heart].
(-)Ephedrine, (+) Ephedrine, (-) psi ephedrine and (+) psi ephedrine inhibit both the neuronal and extraneuronal uptakes of noradrenaline in isolated Rabbit heart. (-) ephedrine is the most active isomer for the inhibition of both neuronal and extraneuronal uptakes. The relative inhibition potential of the three other isomers is not the same when applied to one or other uptake.
D000818:Animals; D004809:Ephedrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D009433:Neural Inhibition / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D013329:Structure-Activity Relationship
D004809:Ephedrine; D009638:Norepinephrine
Relation structure-acitivité de différents isomères de l'éphédrine sur la captation de la noradrénaline par le coeur isolé et perfusé de lapin.