Gas chromatographic determination of glibenclamide in plasma.
A gas-chromatographic method for glibenclamide determination in plasma is described. It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard. Characteristics and specificity of the method for the principal metabolite of glibenclamide are examined.
D000284:Administration, Oral; D002849:Chromatography, Gas / Q000379:methods*; D005905:Glyburide / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D008832:Microchemistry; D014044:Tolbutamide / Q000097:blood
D014044:Tolbutamide; D005905:Glyburide