title: Deposition of IgA in renal glomeruli of mink affected with Aleutian disease.
abstract: The glomerular deposition of immunoglobulin (Ig) was studied in sapphire mink affected with terminal Aleutian disease (AD). Fluorescein conjugated Ig-class specific antiserums were used to evaluate and identify the glomerular Ig. Kidneys of all 28 mink with documented AD had deposits of IgA and beta 1 C in a capillary and mesangial distribution. Only 7 of 28 mink had demonstrable glomerular IgG and/or IgM. In addition, interstitial plasma cell infiltrates in 17 of 19 kidneys stained exclusively with anti-IgA. All antiserums used in this study were evaluated for Ig-class specificity by both gel diffusion and agarose-bead techniques. The striking Ig class restriction demonstrated for glomerular Ig deposition in AD is discussed in light of current knowledge of the pathogenesis of AD glomerulopathy.
mesh_terms: D000453:Aleutian Mink Disease / Q000276:immunology*; D000818:Animals; D005455:Fluorescent Antibody Technique; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M