Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles.
Two new recombinant H-2 haplotypes have been detected and established as congenic resistant lines on the C57BL/10 background. On the basis of serologic testing and immunoprecipitation analyses, the sublocus composition of the first recombinant haplotype, H-2bq1 (B10.MBR) has been shown to be KbIkDq, and that of the second recombinant, H-2sq3 (B10.SQR) to be KsIsSsDq. The occurrence of the Kb I-Ak juxtaposition after a recombination between H-2b and H-2m contrasts with the almost uniform failure to observe H-2b/H-2k recombinants in previous studies. This finding and the occurrence of a second recombination event involving the same chromosome soon after the first in our studies may imply that recombination within H-2 is not generally a random event. The B10.MBR line has proved useful in the production of specific anti-H-2Kb and anti-I-Ab antisera previously quite difficult to obtain contamination by anti-Ia or anti-H-2K antibodies, respectively.
D000483:Alleles; D000818:Animals; D003429:Cross Reactions; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D051379:Mice; D008815:Mice, Inbred Strains; D010375:Pedigree; D011817:Rabbits; D011995:Recombination, Genetic
D006183:H-2 Antigens