Immunological properties of partially purified material with monocytosis-producing activity from Listeria monocytogenes.
A fraction rich in a monocytosis-producing activity (MPA) has been obtained by a two-stage chromatographic separation from a saline extract (SE) of Listeria monocytogenes. Like SE, the purified material elicits monocytosis and decreases the halftime of circulating monocytes. The purification of MPA eliminates the following found in SE: the in vitro mitogenic activity, the in vitro adjuvant activity, the immunosuppressive activity, and the granulocytosis-promoting and the lymphopenia-inducing activities.
D000818:Animals; D005260:Female; D006462:Hemolytic Plaque Technique; D008055:Lipids / Q000276:immunology* / Q000494:pharmacology; D008089:Listeria monocytogenes / Q000032:analysis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008934:Mitogens; D012965:Sodium Chloride; D012995:Solubility; D013154:Spleen / Q000166:cytology; D014867:Water
D008055:Lipids; D008934:Mitogens; D014867:Water; D012965:Sodium Chloride