Influence of contrast media osmolality on isolated rabbit heart performance.
A low osmolality contrast medium (Iopamidol) caused less cardiac disturbance on isolated rabbit heart than a high osmolality medium (Urografin). The same effects were induced by glucose solutions iso-osmolal with the two media. After perfusion with Propranolol (1 microgram/ml) and Cimetidine (1 microgram/ml) the observed effect was unaltered.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003287:Contrast Media; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009994:Osmolar Concentration; D010477:Perfusion; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits
D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D002927:Cimetidine; D011433:Propranolol; D005947:Glucose