Paraproteinemic variety of pure red cell aplasia: immunological studies in 1 patient.
A case of adult pure red cell aplasia (PRCA) with a serum IgG inhibitor to erythropoiesis and an IgG lambda M component is presented. The study of lymphocyte populations revealed a slight but definite decrease of E and EA rosettes, with dissociation between E rosettes and PHA blastic transformation of blood lymphocytes and increase of membrane IgM-bearing lymphocytes. The relationship between PRCA and paraproteinemia is discussed: it is suggested that the serum M component may derive from an immunological unbalance between T and B lymphocytes. Since a survey of the literature reveals 5 similar cases, it is suggested that paraproteinemia may be the hallmark of a particular variety of chronic PRCA 'type 1'.
D000368:Aged; D000741:Anemia, Aplastic / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D004921:Erythropoietin / Q000097:blood; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G; D008214:Lymphocytes / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell; D012397:Rosette Formation
D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell; D004921:Erythropoietin