The metabolic and functional effects of thyroid hormone excess in rats.
Oral administration of thyroid powder for 21 days produces hyperglycemia, hypocholesterolemia, increase of the energetic metabolism ratio and diminishing of the anaerobic metabolism ratio. Prolonged oral administration (30--45 days) induces involution of the thyroid gland, symptoms of an aggravated thyrotoxic hepatosis, hypoglycemia, hypocholesterolemia, a significant increase of the energetic metabolism and of the anaerobic metabolism ratios.
D000818:Animals; D001786:Blood Glucose / Q000096:biosynthesis; D056486:Chemical and Drug Induced Liver Injury; D002784:Cholesterol / Q000097:blood; D004734:Energy Metabolism / Q000187:drug effects*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D007773:Lactates / Q000378:metabolism; D008297:Male; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D013962:Thyroid (USP); D013963:Thyroid Hormones / Q000008:administration & dosage
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D013962:Thyroid (USP); D013963:Thyroid Hormones; D002784:Cholesterol