A preliminary assessment of possible mutagenicity of betel nut and ingredients of the betel quid when administered alone or in combinations to larvae of Drosophila melanogaster.
The "carcinogenic" betel nut and constituents of betel quid were tested for possible mutagenicity in Drosophila. The test compounds were administered either alone or in combinations by larval feeding. The data on sex-chromosome loss, sex-linked recessive lethals and autosomal translocations suggest lack of mutagenicity.
D000818:Animals; D001114:Areca; D002273:Carcinogens / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D003212:Condiments; D004331:Drosophila melanogaster / Q000235:genetics*; D004353:Drug Evaluation, Preclinical; D005804:Genes, Lethal; D005808:Genes, Recessive; D005821:Genetic Techniques; D009153:Mutagens; D010946:Plants, Medicinal; D010947:Plants, Toxic; D014026:Nicotiana
D002273:Carcinogens; D009153:Mutagens