[Evidence of 5 alpha-androstane-3 beta, 6 alpha, 17 beta-triol and of 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol in the anterior pituitary of the prepuberal male rate].
Incubation of 3H-5 alpha-androstane-3 beta, 17 beta-diol with anterior pituitaries from immature male Rats led to the major production of polar radio-metabolites. Of these, 53 and 27% were identified with 5 alpha-androstane-3 beta, 6 alpha, 17 beta-triol and 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol, respectively. The formation of these trihydroxysteroids may be involved in the intracellular regulation of 5 alpha-androstane-3 beta, 17 beta-diol levels.
D015113:Androstane-3,17-diol / Q000378:metabolism; D000731:Androstanes / Q000378:metabolism*; D000818:Animals; D002855:Chromatography, Thin Layer; D003460:Crystallization; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D014316:Tritium
D000731:Androstanes; D014316:Tritium; D015113:Androstane-3,17-diol; D006899:Mixed Function Oxygenases
Mise en évidence du 5 alpha-androstane-3 beta, 6 alpha, 17 beta-triol et du 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol dans l'hypophyse antérieure du rat mâle prépubère.