Platelet antithrombin deficiency: a new clinical entity.
A kindred with a history of multiple thromboses was studied for coagulant abnormalities. A deficiency of serum antithrombin III was found in approximately half of the 13 family members by either coagulant or immunologic assay. No clear relationship between antithrombin III deficiency and a history of thrombosis was present. Platelet antithrombin assays were also studied in the same subjects. Ten of the 13 members were deficient. None of the remaining three had a history of thrombosis. On the basis of these findings, the hypothesis is proposed that in some cases familial hypercoagulability may be due to a platelet antithrombin deficiency and that the serum antithrombin III deficiency in some cases is a secondary rather than a primary effect.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology; D000990:Antithrombin III / Q000032:analysis; D000991:Antithrombins / Q000032:analysis; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000235:genetics*; D001800:Blood Specimen Collection; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008722:Methods; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood* / Q000235:genetics
D000925:Anticoagulants; D000991:Antithrombins; D000990:Antithrombin III