title: Clinical features of 22 cases with "inter-sterno-costo-clavicular ossification". A new rheumatic syndrome.
abstract: We present 22 cases with inter-sterno-costoclavicular ossification. Clinical and pathological findings show that abnormal ossification observed in this situation is due to non-suppurative chronic inflammation of the soft tissues around the sterno-costo-clavicular region such as the costo-clavicular ligament. We have classified X-ray findings into three stages according to the extent of the ossification; localized, generalized, and hyperostotic, and show that the disease progressed in this sequence. A considerable number of the patients showed abnormal X-ray findings in the spine or the sacro-iliac joint. Frequent association of pustulosis palmaris et plantaris was noted in this disease. Most of the cases were treated effectively with anti-inflammatory drugs, but a few cases required surgical resection of the ossified mass with the clavicle or the first rib in order to relieve the severe pain.
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D005533:Foot Dermatoses / Q000150:complications; D006229:Hand Dermatoses / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D012216:Rheumatic Diseases / Q000150:complications*; D013247:Sternoclavicular Joint / Q000000981:diagnostic imaging / Q000601:surgery; D013248:Sternocostal Joints / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone