Priming increases the amount of interferon mRNA in poly(rI).poly(rC)-treated L cells.
Priming by mouse interferon pre-treatment resulted in an accumulation of interferon mRNA in poly(rI).poly(rC)-treated L cells, starting early in the period of interferon synthesis. On electrophoresis, the priming activity of an interferon preparation co-migrated with the antiviral activity, which suggests identity of the functional principle(s) for these activities.
D000818:Animals; D005260:Female; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009522:Newcastle disease virus; D009865:Oocytes / Q000378:metabolism; D011070:Poly I-C / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis*; D012845:Sindbis Virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014981:Xenopus
D012333:RNA, Messenger; D007372:Interferons; D011070:Poly I-C