title: Are histamine H2-receptor depressions of neuronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate?
abstract: Iontophoretic application of histamine H2-agonists depressed spontaneous firing of tuberal hypothalamic neurons in tissue culture. Perfusion with inhibitors of cyclic nucleotide phosphodiesterase increased the strength of these depressions, which persisted during perfusion with Ca2+-free medium. These results support a role of cyclic AMP as a mediator of histamine H2-elicited depressions of neuronal activity.
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / Q000494:pharmacology; D000818:Animals; D046508:Culture Techniques; D000242:Cyclic AMP / Q000502:physiology*; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*
chemical_list: D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D000242:Cyclic AMP; D015056:1-Methyl-3-isobutylxanthine