The effect of lampit on Trypanosoma cruzi in mice organs and in the bloodstream.
Mice infected with bloodstream forms of Trypanosoma cruzi were treated with an active Nitrofuran compound (Nifurtimox, Lampit). Determination of the number of intracellular forms of T. cruzi in the liver and the spleen of control and Lampit-treated mice showed that the drug induced a decrease in the number of parasites inside the cells. A decrease in the number of bloodstream forms was also observed. Ultrastructural observations showed that Lampit induces several alterations in T. cruzi, the most characteristic alteration being the appearance of dense masses localized in the mitochondrial matrix of the parasites.
D000818:Animals; D014355:Chagas Disease / Q000097:blood / Q000469:parasitology*; D008099:Liver / Q000469:parasitology; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D009547:Nifurtimox / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology*; D012270:Ribosomes / Q000187:drug effects; D013154:Spleen / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000648:ultrastructure; D014617:Vacuoles / Q000187:drug effects
D009581:Nitrofurans; D009547:Nifurtimox