Mutagenicity studies with 5-thio-D-glucose. Cytogenetic investigation in mice, and the sex-linked recessive lethal gene test in Drosophila.
Cytogenetic studies in bone marrow cells and dividing spermatocytes I in male mice and the sex-linked recessive lethal gene test in Drosophila melanogaster were initiated to evaluate the mutagenic potential of 5-thio-D-glucose, a reversible male contraceptive in some mammals. The compound was administered by oral intubation to mice at 40 or 60 mg/kg for various time periods. Oregon-R D. melanogaster males were fed medium containing 600 or 1200 ppm of the substance for 72 hours and mated with virgin Muller-5 females to test for gene mutation. The compound did not enhance structural and numerical chromosomal aberrations or elevate sex-linked recessive lethals in D. melanogaster. It is concluded that under the conditions of the present study 5-thio is a nonmutagenic male antifertility agent.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D004331:Drosophila melanogaster / Q000235:genetics*; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D009153:Mutagens; D009154:Mutation; D013091:Spermatogenesis / Q000187:drug effects; D013863:Thioglucosides / Q000494:pharmacology*; D013865:Thioglycosides / Q000494:pharmacology*
D009153:Mutagens; D013863:Thioglucosides; D013865:Thioglycosides