Effect of transection on choline acetyltransferase, thyrotropin releasing hormone and substance P in the cat cervical cord.
The effects of a transection on the choline acetyltransferase activity, the thyrotropin releasing hormone and substance P contents in the cat cervical spinal cord have been investigated. Seven days after the hemitransection at the C1 level, the grey matter of the C6-7 levels of the spinal cord were dissected for the biochemical measurements. The choline acetyltransferase activity and the thyrotropin releasing hormone content remained unchanged in any regions in the grey matter following the high cervical transection. On the other hand, the substance P content was decreased by approx. 70% in the ventral horn. These results suggest that the fibers originating the supraspinal structures and terminating in the grey matter of the spinal cord, contain the substance P-releasing fibers, whereas there seems to be little cholinergic or thyrotropin releasing hormone-containing fibers.
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002415:Cats; D018377:Neurotransmitter Agents / Q000032:analysis*; D013116:Spinal Cord / Q000032:analysis* / Q000201:enzymology / Q000601:surgery; D013373:Substance P / Q000032:analysis*; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*
D018377:Neurotransmitter Agents; D013373:Substance P; D013973:Thyrotropin-Releasing Hormone; D000123:Acetyltransferases