title: [Antidiabetogenic activity of maninyl].
abstract: Experiments were conducted on rabbits. A study was made of the effect of administration of maninyl (glybenclamide) into the stomach in a dose of 10 mg/kg of body weight for 7 days on the blood glucose level, insulin and zinc content in the pancreatic islands, and on the "dithizone" diabetes development. Maninyl administration was accompanied by a significant glycemia reduction. The amount of deposited insulin and zinc determined histochemically was sharply reduced up to complete disappearance from the majority of beta-cells. "Dithizone" diabetes was not reproducible in animals given maninyl preliminarily: the required condition for induction of this affection was formation of zinc dithizonate in beta-cells.
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000037:antagonists & inhibitors*; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D004230:Dithizone / Q000037:antagonists & inhibitors*; D005905:Glyburide / Q000494:pharmacology / Q000627:therapeutic use*; D006651:Histocytochemistry; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D015032:Zinc / Q000378:metabolism
chemical_list: D001391:Azo Compounds; D001786:Blood Glucose; D007328:Insulin; D004230:Dithizone; D015032:Zinc; D005905:Glyburide
vernacular_title: O protivodiabetogennom deĭstvii maninila.