title: [Further observations on the stimulation of the secondary immunological response in the Rh system].
abstract: The present paper is a continuation of studies for establishing the optimal schedule of blood-donor immunization for obtaining of plasma suitable for production of anti-RhD immunoglobulin. After 3 years of observation of 12 immunized subjects it was found that stimulation of the secondary immune response should be done with small doses (0.5-1 ml) of blood injected intravenously at long time intervals, that is 1-3 times in a year. This method leads to a high and long-term rise in the titre of antibodies exceeding in all cases the value of 1/128 in indirect antiglobulin test, that is suitable for production of the preparation Gamma anti-D 150.
mesh_terms: D000917:Antibody Formation; D001782:Blood Donors; D006801:Humans; D007117:Immunization, Secondary; D012204:Rh-Hr Blood-Group System; D013997:Time Factors
chemical_list: D012204:Rh-Hr Blood-Group System
vernacular_title: Dalsze obserwacje nad stymulacja wtórnej odpowiedzi immunologicznej w układzie Rh.