Vitreoretinal degeneration as a sign of generalized connective tissue diseases.
Dominant vitreoretinal degeneration was first described by Wagner as a benign ocular condition. This term has since become widely associated with a familial retinal degenerative process accompanied by retinal detachments, even though nobody in the family described by Wagner suffered from a retinal detachment. Vitreoretinal degeneration, often progressing to detachments, occurs also in several distinct bone dysplasias. I have provided a classification of syndromes with vitreoretinal degeneration and its signficance as a sign of connective tissue diseases (probably involving type II collagen). In this sense, it is similar to ectopia lentis as a sign of various connective tissue diseases.
D000015:Abnormalities, Multiple / Q000150:complications; D000293:Adolescent; D000328:Adult; D001848:Bone Diseases, Developmental / Q000150:complications / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008382:Marfan Syndrome / Q000150:complications; D009085:Mucopolysaccharidosis IV / Q000150:complications; D009216:Myopia / Q000150:complications / Q000235:genetics*; D012162:Retinal Degeneration / Q000150:complications / Q000235:genetics*; D013577:Syndrome; D014822:Vitreous Body