The effect of organic nitrites and nitrates on glycogenolytic activity in the heart and skeletal muscle.
Organic nitrites (sodium nitrite, amyl nitrite) and nitrates (nitroglycerin, pentaerythritol, nitromannite) affect similarly phosphorolytic, amylolytic and total glycogenolytic activities in the heart and skeletal muscle. The action of these drugs on glycogen metabolism is due to liberation of adrenaline and concurrent inhibition of its effect on enzymatic activities. The drugs antagonize the stimulatory action of adrenaline on phospholytic activity and inhibitory action on amylolytic activity.
D000818:Animals; D002395:Catecholamines / Q000097:blood; D006003:Glycogen / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009566:Nitrates / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
D002395:Catecholamines; D009566:Nitrates; D009573:Nitrites; D006003:Glycogen; D005996:Nitroglycerin