[Circadian variations of the plasma proteins in the adult male rat under natural synchronisation (author's transl)].
Circadian rhythms of blood total proteins, albumin, alpha 1-, alpha 2-, beta- and gamma-globulins were documented in 80 Wistar SPF adult male rats, synchronized by natural light (06.00-18.00 h) and darkness (18.00-06.00 h) during the month of October 78. Blood was sampled at four fixed time points in the 24 h scale (i.e. 04.00, 10.00, 16.00 or 24.00 h). Total proteins, albumin, alpha 2- and gamma-globulins showed a statistically significant rhythm with a maximum at 04.00 h. The data obtained in anaesthetized rats under artificial synchronization and in man are compared, taking into account that the rat is a nocturnally active rodent. The present work partially confirms the hypotheses of previous chronopharmacological studies, thus e.g. curarizing substances have a mimimum activity when the protein plasma level, especially albumin, is the highest.
D000510:Alpha-Globulins / Q000378:metabolism; D000818:Animals; D001609:Beta-Globulins / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D002940:Circadian Rhythm; D008027:Light; D008297:Male; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism
D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D012709:Serum Albumin; D005719:gamma-Globulins
Variations circadiennes des protéines plasmatiques chez le rat mâle adulte en synchronisation naturelle.