title: Pulmonary function changes in normal rats induced by antibody against rat IgE.
abstract: Changes in pulmonary function, as measured by airway conductance and dynamic compliance, in normal rats have been provoked by the administration of a rabbit antisera prepared against rat IgE myeloma protein. The response is specific in that neither anti-IgG nor normal rabbit serum induced pulmonary changes. Pre-treatment with disodium cromoglycate inhibits the bronchospasm in a dose related manner. In addition, drug protection can be demonstrated with as long 1 hr pre-dosing.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001986:Bronchial Spasm / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D004205:Cromolyn Sodium / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E / Q000276:immunology*; D008170:Lung Compliance; D012123:Pulmonary Ventilation; D051381:Rats; D013997:Time Factors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E; D004205:Cromolyn Sodium