title: The arrangement and rearrangement of antibody genes.
abstract: Cloned segments of mouse chromosomal DNA provide direct evidence for the somatic rearrangement of kappa variable and constant region genes in antibody producing cells. This rearrangement apparently affects only one member of an allelic pair of light chain genes.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000378:metabolism; D001483:Base Sequence; D001666:Binding Sites, Antibody / Q000235:genetics*; D004622:Embryo, Mammalian / Q000276:immunology; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D051379:Mice; D009194:Myeloma Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010954:Plasmacytoma / Q000276:immunology
chemical_list: D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins; D009194:Myeloma Proteins