title: Comparative mutagenicity of palmotoxin Bo and aflatoxins B1 and M1.
abstract: The mutagenicity of palmotoxin Bo and of aflatoxin M1 relative to that of aflatoxin B1, the potent mutagen, was studied in five Ames' Tester Strains of Salmonella typhimurium (TA-98, TA-100, TA-1535, TA-1537, TA-1538). Aflatoxins B1 and M1 are both highly mutagenic in a microsome-mediated system in TA-100. The prediction of the relative carcinogenicity of aflatoxin M1 to aflatoxin B1 posed by the mutation of TA-100 is probably more authentic than TA-87. The mutagenic potency of palmotoxin Bo is less than that of either aflatoxin B1 or M1.
mesh_terms: D000348:Aflatoxins / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001231:Aspergillus flavus / Q000032:analysis; D006900:Hydroxylation; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009183:Mycotoxins / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000348:Aflatoxins; D009153:Mutagens; D009183:Mycotoxins; C008759:palmotoxin Bo