alpha-Amanitin: inactivation by bovine lactoperoxidase.
The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.
D000546:Amanitins / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004331:Drosophila melanogaster / Q000201:enzymology; D066298:In Vitro Techniques; D007784:Lactoperoxidase / Q000378:metabolism / Q000494:pharmacology*; D010544:Peroxidases / Q000494:pharmacology*; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors; D013997:Time Factors
D000546:Amanitins; D007784:Lactoperoxidase; D010544:Peroxidases; D012319:RNA Polymerase II