title: Genetics of complement deficiencies associated with lupus-like syndromes.
abstract: There appears to be an association between deficiencies of a number of complement components, particularly of the second component (C2), and rheumatic diseases, especially lupus. The meaning of this association is not clear, but the linkage of deficiency of C2 with HLA, especially HLA-A10, B18, Dw2, as well as with BfS, suggests a possible linkage to immune response genes.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003175:Complement C2 / Q000172:deficiency; D011415:Complement Factor B; D003165:Complement System Proteins / Q000172:deficiency*; D005802:Genes, MHC Class II; D005838:Genotype; D006680:HLA Antigens; D006579:Heterozygote; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*
chemical_list: D003175:Complement C2; D006680:HLA Antigens; D003165:Complement System Proteins; D011415:Complement Factor B