Axoplasmic transport blockage therapy in herpes zoster ophthalmicus.
Three patients with herpes zoster ophthalmicus were treated with an oral administration of colchicine and corticosteroid, while another seven were given systemic corticosteroid, vitamins, and sedatives. Colchicine inhibited the formation of new skin lesions but did not suppress the already grown vesicles. The effect of colchicine was attributed to a blockage of intra-axonal dissemination by neurotrophic virus.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001370:Axonal Transport / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014780:Viruses / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D003078:Colchicine