title: Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster.
abstract: Uptakes of guanine into Malpighian tubules of wild-type Drosophila and the eye color mutants white (w), brown (bw), and pink-peach (pp) have been compared. Tubules for each of these mutants are unable to concentrate guanine intracellularly. The transport of xanthine and riboflavin is also deficient in w tubules. The transport of guanosine, adenine, hypoxanthine, and guanosine monophosphate is similar in wild-type and white Malpighian tubules. These data and other information about these mutants make it likely that these pteridine-deficient eye color mutants do not produce pigments because of the inability to transport a pteridine precursor. This view supports the hypothesis that mutants which lack both pteridine and ommochromes do so because precursors to both classes of pigments share a common transport system.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002988:Cloaca / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D005127:Eye Color; D006147:Guanine / Q000378:metabolism*; D008317:Malpighian Tubules / Q000378:metabolism*; D009154:Mutation; D012256:Riboflavin / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
chemical_list: D014970:Xanthines; D006147:Guanine; D012256:Riboflavin