title: Effect of the acute administration of haloperidol and pimozide on plasma GH levels in acromegaly.
abstract: In 11 untreated acromegalic patients the plasma GH levels were determined after the acute administration of bromocriptine, haloperidol, pimozide (only in 8 patients) and of placebo. A 50% or more suppression of the basal GH levels was arbitrarily defined as a positive response to bromocriptine. Five patients displayed a negative response to bromocriptine. Of these, 4 responded to both antidopaminergic drugs. We conclude that the acute administration of antidopaminergic drugs reduces the GH secretion in some bromocriptine-insensitive acromegalic patients. Therapeutical implications will require further studies.
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000188:drug therapy*; D000284:Administration, Oral; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010868:Pimozide / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use
chemical_list: D010919:Placebos; D010868:Pimozide; D001971:Bromocriptine; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D006220:Haloperidol