Platelet dysfunction in patients with vitamin B12 deficiency.
10 cases of pernicious anaemia are reported in which 6 had abnormal aggregation with epinephrine, 3 with fibrinogen, 2 with ADP, and 2 with ristocetin. 5 patients had thrombocytopenia and 3 of these had a prolongation of the bleeding time. These abnormalities were normalized after vitamin B12 treatment. After treatment, platelet size changed toward a smaller diameter, but platelet size, however, was not significantly different from the normal platelet size distribution.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D001772:Blood Cell Count; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000209:etiology*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005340:Fibrinogen / Q000494:pharmacology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology; D013921:Thrombocytopenia / Q000150:complications; D014805:Vitamin B 12 / Q000627:therapeutic use
D006454:Hemoglobins; D012310:Ristocetin; D000244:Adenosine Diphosphate; D005340:Fibrinogen; D003094:Collagen; D014805:Vitamin B 12; D004837:Epinephrine