title: [Intensification of antibacterial and antiviral nonsusceptibility and of the immune response with an officinal RNA preparation].
abstract: Sodium nucleinate increased essentially the insusceptibility of mice to pathogenic escherichia, strain O26, Pr. vulgaris, Ps. aeruginosa, Ser. marcescens, and produced a total stimulating effect on the nonspecific bacterial resistance; analogous stimulating activity was found in the homologous low polymeric RNA from the liver. Sodium nucleinate intensified the insusceptibility of the animals to the tick-born encephalitis and encephalomyelitis viruses, and increased the antibody-forming cells count. The side-effect of heat-inactivated vaccine from pathogenic escherichia was reduced in animals inoculated with sodium nucleinate preliminarily.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000921:Antibody-Producing Cells / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004667:Encephalitis Virus, Western Equine / Q000472:pathogenicity; D004669:Encephalitis Viruses, Tick-Borne / Q000472:pathogenicity; D004926:Escherichia coli / Q000472:pathogenicity; D007113:Immunity, Innate / Q000187:drug effects*; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D009696:Nucleic Acids / Q000276:immunology; D011514:Proteus vulgaris / Q000472:pathogenicity; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity; D012313:RNA / Q000276:immunology*; D012706:Serratia marcescens / Q000472:pathogenicity; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D009696:Nucleic Acids; D012313:RNA; C013683:sodium nucleinate
vernacular_title: Usilenie antibakterial'noĭ, antivirusnoĭ nevospriimchivosti i immunogo otveta ofitsinal'nym preparatom RNK.