title: [Change in ratio between citric and oxalic acid in Aspergillus niger upon exposure to mutagenic factors].
abstract: Stepwise selection of Aspergillus niger producing citric acid in highly buffered molassa media was carried on in order to decrease the biosynthesis of oxalic and gluconic acids using the following mutagenic factors: diethyl sulfate, thiophosphamide, cyclophosphan, N-methyl-N'-nitro-N-nitrosoguanidine (NG), 5-fluorouracil, 1,4-bis-diazoacetylbutane, and UV. The ratio between the acids changed in mutants obtained upon the combined treatment with UV and NG. Mutants producing twice as less oxalic acid were characterized by weak growth and formation of conidia.
mesh_terms: D001234:Aspergillus niger / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D001391:Azo Compounds / Q000494:pharmacology; D002951:Citrates / Q000096:biosynthesis*; D003520:Cyclophosphamide / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D010070:Oxalates / Q000096:biosynthesis*; D013431:Sulfates / Q000494:pharmacology; D013852:Thiotepa / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D001391:Azo Compounds; D002951:Citrates; D009153:Mutagens; D010070:Oxalates; D013431:Sulfates; D008769:Methylnitronitrosoguanidine; D003520:Cyclophosphamide; D013852:Thiotepa; D005472:Fluorouracil
vernacular_title: Izmenenie sootnosheniia limonnoĭ i shchavelevoĭ kislot u Aspergillus niger pod vliianiem mutagennykh faktorov.