Spasticity due to phenytoin toxicity.
A young epileptic presented with spasticity as well as ataxia, diplopia and nystagmus; his serum phenytoin level was very high. All the abnormal signs disappeared after withdrawal of phenytoin. Spasticity, hyperreflexia, and clonus are features of phenytoin intoxication, present in this case, which are not commonly seen, and which have rarely been mentioned previously in the literature.
D000328:Adult; D001259:Ataxia / Q000139:chemically induced; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D006801:Humans; D008297:Male; D009128:Muscle Spasticity / Q000139:chemically induced*; D010672:Phenytoin / Q000009:adverse effects*; D012021:Reflex, Abnormal / Q000139:chemically induced
D010672:Phenytoin