Alien H-2 allospecificities in murine chemically-induced tumors.
Sera from C3H/HeHa mice immunized with syngeneic methylcholanthrene-induced sarcoma react with allogeneic thymus, lymphoma and leukemia cells. The presence on leukemia and lymphoma cells of H-2 specificities expressed on normal cells of other H-2 haplotypes from the one in which the tumor originates is described. It was observed that the reaction of antisera to H-2 specificities with lymphoma cells was blocked by anti-MCA sarcoma sera. The cross-reactivity between MC sarcomas, thymus, leukemia and lymphoma cells is considered to be due to antibodies against these "alien" allospecificities.
D000818:Animals; D000912:Antibodies, Neoplasm; D001667:Binding, Competitive; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005260:Female; D006183:H-2 Antigens; D007106:Immune Sera / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D011817:Rabbits; D012513:Sarcoma, Experimental / Q000139:chemically induced
D000912:Antibodies, Neoplasm; D000939:Epitopes; D006183:H-2 Antigens; D007106:Immune Sera; D008748:Methylcholanthrene