Fanconi's anemia: the preanemic phase.
Anticipation of Franconi's anemia prior to the development of overt marrow aplasia may prevent some morbidity and mortality from infectious and hemorrhagic complications. A presumptive diagnosis was made in a firstborn child and radial anomalies, small size, elevated fetal hemoglobin, intermittent excessive chromosome breakage and elevated T-antigen expression in fibroblasts infected with Simian virus 40. Serial studies may help identify infants and young children at risk to develop this type of constitutional marrow hypoplasia.
D000741:Anemia, Aplastic / Q000175:diagnosis*; D000956:Antigens, Viral / Q000032:analysis; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005199:Fanconi Anemia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D013539:Simian virus 40 / Q000276:immunology
D000956:Antigens, Viral; D005319:Fetal Hemoglobin