[Effect of ergoline derivatives on platelet and blood vessels].
The influence of dihydrogenated ergot alkaloids on vessels and blood platelets was studied in vitro and in vivo. At low concentrations they cause contraction of isolated vein strips via a stimulation of alpha-adrenoceptors, at higher concentrations they antagonize the action of noradrenaline on arteries and veins and inhibit the adrenaline-induced platelet aggregation in vitro. In volunteers, intravenous and subcutaneous administration of dihydroergotamine (Dihytamin) caused a decrease in blood volume of the capacitance vessels and inhibition of the adrenaline-potentiated platelet aggregation "ex vivo". The selective venoconstrictor and antiaggregating effects of dihydroergotamine are utilized in the postoperative prophylaxis of thrombosis.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology; D004837:Epinephrine; D004873:Ergolines / Q000494:pharmacology*; D006801:Humans; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013927:Thrombosis / Q000517:prevention & control; D014661:Vasoconstriction / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D004873:Ergolines; D004087:Dihydroergotamine; D009638:Norepinephrine; D004837:Epinephrine
Wirkung von Ergolinderivaten auf Blutplättchen und Gafässe.