title: Pre-immunization and post-exposure treatment with inactivated rabies vaccine of chick embryo cell culture origin (CEC).
abstract: Routine laboratory assay revealed that the potency of concentrated rabies vaccine of chick embryo cell culture (CEC) origin was in the same level compared with suckling mouse brain (SMB) vaccine. Over one hundred persons received two doses of CEC vaccine at an interval of one week and produced high level of neutralizing antibody against rabies virus. The monkeys experimentally infected with street rabies virus were satisfactorily protected by subcutaneous inoculation with CEC vaccine one hour after exposure. Eight persons bitten by dogs known to have rabies or suspected of it, survived after post-exposure treatment with CEC vaccine.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D046508:Culture Techniques; D005260:Female; D000882:Haplorhini; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D011818:Rabies / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D011819:Rabies Vaccines / Q000276:immunology / Q000302:isolation & purification / Q000627:therapeutic use*; D014613:Vaccines, Attenuated
chemical_list: D011819:Rabies Vaccines; D014613:Vaccines, Attenuated