[Bioavailability and local anesthetic effect of the combination of tyrothricin, fomocain, diphenhydramine and 8-hydroxyquinoline in a gel preparation for burns and wounds].
The biological availability was investigated of diphenhydramine and fomocaine, two of the active principles of the new formulation "Herit" used as a jelly against burns and small wounds. Fomocaine and diphenhydramine penetrate deeply into stratum corneum. The addition of fomocaine guarantees a quick pain relieving effect on the damaged skin. The jelly does not retain diphenhydramine and fomocaine.
D000287:Administration, Topical; D000779:Anesthetics, Local; D001682:Biological Availability; D002056:Burns / Q000188:drug therapy; D004155:Diphenhydramine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D004338:Drug Combinations; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D015125:Oxyquinoline / Q000008:administration & dosage; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D014449:Tyrothricin / Q000008:administration & dosage; D014947:Wounds and Injuries / Q000188:drug therapy
D000779:Anesthetics, Local; D004338:Drug Combinations; D005782:Gels; D010647:Phenyl Ethers; D014449:Tyrothricin; D015125:Oxyquinoline; D004155:Diphenhydramine
Bioverfügbarkeit und lokalanästhetische Wirkung eines Brand- und Wundgels in der Kombination von Tyrothricin, Fomocain, Diphenhydramin und 8-Hydroxychinolin.