title: [The correlation of in vivo and in vitro effect of cytostatics in transplantated tumours of the mouse (author's transl)].
abstract: In 2 inoculated mouse tumours the conformity of the actions of 4 different cytostatics at 2 dose levels was tested in vitro and in vivo. The histochemical reaction of lactate dehydrogenase and NADH diaphorase was taken as a criterion of the cytostatic action. The investigations showed the tumours used responded to the cytostatics employed. A good conformity of the in vitro and in vivo findings was established. The histochemical assessment of organ cultures following the administration of cytostatics allows to determine the sensitivity of tumours and helps the physician in deciding on an effective therapeutic.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000201:enzymology; D008058:Dihydrolipoamide Dehydrogenase / Q000032:analysis; D005472:Fluorouracil / Q000627:therapeutic use; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D051379:Mice; D009368:Neoplasm Transplantation; D014747:Vinblastine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D014747:Vinblastine; D007770:L-Lactate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D005472:Fluorouracil
vernacular_title: Zur Korrelation der in vivo- und in vitro-Wirkung von Cytostatika auf Transplantationstumoren der Maus.