Differentiation and regulation of lymphocyte populations: evidence for immunopotentiator-induced T cell recruitment.
Isoprinosine, the p-acetaminobenzoic acid salt of inosine dimethylaminoisopropanol (1:3 molar ratio) and sodium diethyldithiocarbamate are two immumopotentiators which share an ability to induce in vivo acquisition of a specific T-cell marker by undifferentiated precursor lymphoid cells of healthy nu/nu mice, without affecting the B-cell lineage. Serum from treated nu/nu mice tested in dual assays, contains a selective inducer of prothymocytes.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation; D004050:Ditiocarb / Q000494:pharmacology; D007542:Inosine Pranobex / Q000494:pharmacology; D051379:Mice; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects
D000276:Adjuvants, Immunologic; D004050:Ditiocarb; D007542:Inosine Pranobex