Pulmonary function changes in normal rats induced by antibody against rat IgE.
Changes in pulmonary function, as measured by airway conductance and dynamic compliance, in normal rats have been provoked by the administration of a rabbit antisera prepared against rat IgE myeloma protein. The response is specific in that neither anti-IgG nor normal rabbit serum induced pulmonary changes. Pre-treatment with disodium cromoglycate inhibits the bronchospasm in a dose related manner. In addition, drug protection can be demonstrated with as long 1 hr pre-dosing.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001986:Bronchial Spasm / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D004205:Cromolyn Sodium / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E / Q000276:immunology*; D008170:Lung Compliance; D012123:Pulmonary Ventilation; D051381:Rats; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E; D004205:Cromolyn Sodium