[Effect of noradrenaline on its own internal liberation from cortex synaptosomes in the rat].
Norepinephrine (NE) uptake velocity in rat cerebral cortex synaptosomes does not depend on internal NE contents: continuous exchange occurs. NE enhances spontaneous release and inhibits release elicited by KCl. Phenylephrine an a agonist, produces the same effect. Phentolamine, an a antagonist, did not modified the spontaneous release but enhanced release elicited by KCl 25 mM.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D010656:Phenylephrine; D011189:Potassium Chloride; D003042:Cocaine; D009638:Norepinephrine; D010646:Phentolamine
Effet de la noradrénaline sur sa propre libération dans des synaptosomes de cortex de rat.