Effect of FR 7534, a new calcium antagonist, on myocardial oxygen demand.
The actions of FR 7534, a new calcium antagonist, nitroglycerin, and dipyridamole on myocardial oxygen demand have been compared. Six anaesthetized dogs received two infusion levels of each drug which produced equivalent arterial hypotension. All three compounds reduced the tension-time index (TTI). FR 7534 and nitroglycerin but not dipyridamole produced significant decreases in myocardial oxygen consumption (MVO2). FR 7534 demonstrated oxygen-sparing actions comparable to nitroglycerin. FR 7534 may prove beneficial in alleviating myocardial ischemia.
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors*; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009543:Nifedipine / Q000031:analogs & derivatives; D005996:Nitroglycerin / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*
D011725:Pyridines; C019137:FR 7534; D004176:Dipyridamole; D005996:Nitroglycerin; D009543:Nifedipine; D010100:Oxygen; D002118:Calcium