[Development of experimental brain tumors in modulated amine metabolism].
There was found a correlation between dynamic changes in the serotonin level and mortality in rats with 9,10-dimethyl-1,2-benzanthracene induced blastomogenesis. An estimation was made of the influence of monoamine oxidase inhibitors, transamine and D, L-malic acid benzyldihydrazide on the type of a tumor produced. Chemical blastomogenesis in the case of cerebellar tumors is shown to be associated with the decreased serotonin content at the site of a tumor. But fluctuations of the serotonin level in the hypothalamus have not been detected. This evidenced that the decreased mortality rate caused by the administration of monoamine oxidase inhibitor is due to a lower production of astrocytomas and genetically related glioblastomas. The role of serotonin in increasing the astrocyte resistance to malignant degeneration has been discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000588:Amines / Q000378:metabolism*; D000818:Animals; D001932:Brain Neoplasms / Q000209:etiology* / Q000378:metabolism; D002528:Cerebellar Neoplasms / Q000209:etiology / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D000588:Amines; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D015127:9,10-Dimethyl-1,2-benzanthracene
O razvitii éksperimental'nykh opukholeĭ mozga v usloviiakh moduliatsii obmena aminov.