title: [Antiarrhythmic properties of 3-(2-hydroxy-3 isopropylamino-propoxy)-3 phenyl-2 isoindolinone-1, (RS, SR) in the dog].
abstract: In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias.
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007211:Indoles / Q000627:therapeutic use*; D009200:Myocardial Contraction / Q000187:drug effects; D010042:Ouabain; D011412:Propanolamines / Q000627:therapeutic use*; D011802:Quinidine / Q000627:therapeutic use; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D007211:Indoles; D011412:Propanolamines; D010042:Ouabain; D011802:Quinidine
vernacular_title: Propriétés anti-arythmiques de l'(hydroxy-2 isopropylamino-3 propoxy)-3 phényl-2 isoindolinone-1, (RS, SR) chez le chien.