Tissue reacting antibodies in a rhesus monkey with long-term Trypanosoma cruzi infection.
Immunoglobulins (Igs) reacting against endothelial and vascular structures and striated muscle cells as well as against cells from a peripheral nerve were detected by indirect immunofluorescent test (IIF) in a rhesus monkey infected for 29 yr with Trypanosoma cruzi. Anti-T. cruzi antibodies in this monkey showed a titer of 1:128 in the IIF test and the direct agglutination test. Tissue-reacting Igs were bound in vivo to the tissues, as was established by direct treatment of a biopsy of the deltoid muscle with Ig-labeled antisera. Electron microscopy of this tissue showed that Igs reacted with the plasma membrane of the muscle cells. Neither tissue-reacting Igs nor specific antibodies were detected in three uninfected adult monkeys.
D000818:Animals; D001323:Autoantibodies; D014355:Chagas Disease / Q000276:immunology*; D004727:Endothelium / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D008251:Macaca / Q000276:immunology*; D008297:Male; D009132:Muscles / Q000276:immunology
D001323:Autoantibodies