[The structural catalytic characteristics of brain acetylcholinesterase in rabbit postnatal ontogeny].
Studies have been made on structural and catalytic peculiarities of acetylcholinesterase (AChE) in the large hemispheres of newborn, 1-month and adult rabbits. During postnatal life, no changes were found in the structure of active surface of the enzyme, although differences were revealed in macromolecular organization and sensitivity of the enzyme to allosteric ligands. It is suggested that structural organization of AChE in postnatal ontogenesis becomes more complex which provides for more precise regulation of its activity.
D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism*; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000495:Allosteric Site / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D002384:Catalysis / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D046911:Macromolecular Substances; D011817:Rabbits
D002800:Cholinesterase Inhibitors; D046911:Macromolecular Substances; D000110:Acetylcholinesterase
Izuchenie strukturno-kataliticheskikh osobennosteĭ atsetilkholinésterazy mozga v postnatal'nom ontogeneze krolikov.