Cellular mechanics of dentinal bridge repair using 3H-thymidine.
Cellular reorganization in the pulp following mechanical pulp exposure involves three steps: First, lysis and macrophage resolution of the clot form; second, there is an invasion of the clot area by fibroblasts and endothelial cells, i.e., formation of granulation tissue; third, an organization and differentiation of these cells into functional odontoblasts occurs as early as 9 days after exposure. Autoradiographic results showed an increased DNA synthesis in the fibroblast and endothelial cell populations which coincided with a histologically-observed increase in those populations. A relative increase in fibroblastic activity, as compared to endothelial cell activity, suggested that fibroblasts may be the cells that replace odontoblasts.
D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D004247:DNA / Q000096:biosynthesis*; D003782:Dental Pulp / Q000166:cytology* / Q000378:metabolism; D003789:Dental Pulp Exposure / Q000379:methods; D003809:Dentin, Secondary / Q000166:cytology* / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D000882:Haplorhini; D008253:Macaca mulatta; D009804:Odontoblasts / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D004247:DNA; D013936:Thymidine