[Concentrations of cytostatic drugs in organs and tumors: comparison after intravenous and intratumoral injection (author's transl)].
The cytostatic drugs Chlorambucil and Bleomycin were labeled with 131I and with 57Co, respectively: Ruthenocenealdehyde-(N-methyl-N-beta-chlorethyl)-hydrazone and Ruthenocene-3-phenyl-prop.1-en-3-one were labeled with the gamma emitter 103Ru. In tumor-bearing mice the elimination and organ distribution of these radioactive substances were tested after intravenous (i.v.) and intratumoral (i.t.) injection of the drugs. The organ load showed lower values after i.t. than after i.v. application, while the radioactivity concentrations in the tumor were considerably increased after i.t. injection. The integrals of the concentration-time curves showed 10--80 times higher concentrations in the tumor after i.t. compared to i.v. injection of the drugs.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D001761:Bleomycin / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002699:Chlorambucil / Q000378:metabolism; D005260:Female; D006835:Hydrazones / Q000378:metabolism; D007267:Injections; D008657:Metabolic Clearance Rate; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009942:Organometallic Compounds / Q000378:metabolism; D011427:Propiophenones / Q000378:metabolism; D012428:Ruthenium / Q000378:metabolism; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D006835:Hydrazones; D009942:Organometallic Compounds; D011427:Propiophenones; D001761:Bleomycin; C016721:ruthenocene; D002699:Chlorambucil; D012428:Ruthenium
Cytostatika-Konzentrationen in Organen und Tumoren: Vergleich nach intravenöser und intratumoraler Injektion.