Studies of estrogen induced renal tumours in male Syrian hamsters. I. Cytochemical studies of lysosomal enzymes acid phosphatase and beta-glucuronidase.
The localization and concentration of lysosomal enzymes acid phosphatase and beta-glucuronidase in kidney cells of Syrian hamsters after DES administration were studied. A positive cytoplasmic reaction was demonstrated for both enzymes. Increased activity of these enzymes were observed in renal tumour in contrast to normal homologous cells. These results can be explained on the basis that lysosomal enzymes were synthesized in tumour cells at a higher rate or it may be due to the invasion of tumour tissue by hydrolase rich microphages.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D004054:Diethylstilbestrol; D005966:Glucuronidase / Q000378:metabolism; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D013997:Time Factors
D004054:Diethylstilbestrol; D000135:Acid Phosphatase; D005966:Glucuronidase