[Serum thyroid hormones and TSH response to TRH during treatment of Graves' disease by carbimazole (author's transl)].
Serum concentrations of Thyroxine (T4), triiodothyronine (T3) free thyroxine index (F.T.I.) and TSH response to TRH were evaluated in 55 Graves' diseases treated by Carbimazole. There is a good correlation between serum thyroid hormones and clinical state: 83,7% for T4; 79,5% for T3; on the other hand there is a discrepancy between T3 and T4 in many cases and between delta TSH and T4 (47%) or T3 (46%). The decrease of T4 occurs before that of T3: 46,6% normal at the 4th month and 72,5% at the 9th month for T4 against 41% and 50% for T3. At the end of the treatment 96,4% of patients are clinically normal but 20% of them remain with T3 and T4 values above normal.
D002231:Carbimazole / Q000627:therapeutic use*; D006111:Graves Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013963:Thyroid Hormones; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D002231:Carbimazole; D013972:Thyrotropin; D013974:Thyroxine
Hormones thyroïdiennes plasmatiques et test à la TRH au cours de la maladie de Basedow traitée par le carbimazole.