[Comparative study of cicatrization with suture technics in 1 or 2 layers in small intestine anastomosis in adverse conditions. Experimental work in dogs].
Some experimental procedures have shown in intestinal anastomosis advantages in the use of suture on only one plane as compared to the classical suture on two planes. However, these experiments, performed in healthy dogs, raised doubts about its safety when used under adverse clinical conditions. The objective of this work is, therefore, to compare in dogs submitted to immunosupressive drugs (azotioprine and corticoid) the two techniques of suture in the presence of peritonitis and intestinal ischemia. The comparative study of the healing in the sutures performed under such conditions shows the advantages in the use of suture on only one plane. In the dogs examined on the fourth and fifteenth day after surgery, the superiority of the suture on one plane compared to that on two planes is evident, both in the macroscopic and microscopic aspects. The suture in one plane shows a better coadaptation of the borders, without increasing the thickness of the wall at the level of the anastomosis, less exudative inflammatory reaction, quicker and greater fibroblastic proliferation, less inflammatory reaction to the suture material, and less vascular alteration at the healing level.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology / Q000627:therapeutic use; D007421:Intestine, Small / Q000098:blood supply / Q000601:surgery*; D007511:Ischemia / Q000601:surgery*; D008297:Male; D008722:Methods; D010538:Peritonitis / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D013536:Suture Techniques; D014945:Wound Healing / Q000187:drug effects
D001379:Azathioprine; D006854:Hydrocortisone
Estudo comparativo da cicatrizaçao com tecnicas de suturas em um e dois planos em anastomoses do intestino delgado em condiçoes de adversidade. Trabalho experimental no cao.