Acute promyelocytic leukemia in childhood. Report of a case with a review of the literature.
A rare case of acute promyelcytic leukemia (APL) is reported in a 7-year-old boy. The patient displayed the typical features of APL including impaction of the marrow with promyelocytes, marked elevation of the serum vitamin B12 and transcobalamin I levels and a hemorrhagic diathesis. The bleeding diathesis in the case was due to thrombocytopenia, and there was no evidence for disseminated intravascular coagulation.
D001853:Bone Marrow / Q000473:pathology; D002648:Child; D003581:Cytodiagnosis; D003630:Daunorubicin / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D018805:Sepsis / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology
D003630:Daunorubicin