[Genetic control by the HLA region of the immune response to factor VIII in hemophilic patients].
In 10 sibships of haemophilic A patients, every one including 1 haemophilic brother with an antibody to factor VIII and 1 haemophilic brother without antibody, pattern of HLA segregation was analysed. All sibships were HLA haploidentical or different and not HLA identical. This fact suggested a linkage between the major histocompatibility complex and an "Ir" gene to factor VIII.
D005169:Factor VIII / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000276:immunology*; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008285:Major Histocompatibility Complex
D006680:HLA Antigens; D005169:Factor VIII
Contrôle génétique par la région HLA de la réponse immunitaire au facteur VIII chez les hémophiles.