[Surface changes of the pulmonary valve following pulmonary valve xenotransplantation in the descending aorta. An experimental study in dogs].
Upon implantation in the descending aorta, glutaraldehyde-conditioned pulmonary valves (n = 46) are immediately covered by a protein layer, followed by a fibrinous layer. Two to thirty minutes later platelets, WBCs, macrophages, and microthrombi are incorporated into the valve's surface. After 3 weeks the first collagen fibers appear on the surface and slowly build a collagen layer that grows toward the free edge. These changes are very similar to the surface changes of bioprostheses implanted in humans.
D000818:Animals; D001705:Bioprosthesis; D004285:Dogs; D005976:Glutaral / Q000494:pharmacology; D006350:Heart Valve Prosthesis; D011664:Pulmonary Valve / Q000601:surgery / Q000637:transplantation / Q000648:ultrastructure*; D013552:Swine; D013997:Time Factors; D014183:Transplantation, Heterologous
D005976:Glutaral
Die Oberflächenveränderungen der Pulmonalklappen nach Pulmonalklappen-Xenotransplantation in die Aorta descendens. Eine experimentelle Studie an Hunden.