title: Mutagenicity tests with griseofulvin.
abstract: Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse. It was also tested for its capacity to produce his+ revertants in Salmonella typhimurium. All tests yielded negative results, whereas highly significant effects were recorded in control assays with thio-TEPA.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D003338:Corpus Luteum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006118:Griseofulvin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D012098:Reproduction / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology
chemical_list: D006118:Griseofulvin; D013852:Thiotepa