Genetic control of the immune response to hen's egg-white lysozyme in mice. I. Antibody and T-lymphocyte proliferative responses to the native protein.
We have initiated studies to determine whether the antibody and T-lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H-2f, H-2k and H-2p were high responders, while haplotypes H-2b,  H-2d, H-2r and H-2s were low responders. Studies with recombinants indicated that the immune response is controlled by two H-2I region loci, one being in the I-A subregion and the other may be in the I-C subregions.
D000818:Animals; D000917:Antibody Formation; D002455:Cell Division; D002645:Chickens; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006238:Haploidy; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009113:Muramidase / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000166:cytology*
D006183:H-2 Antigens; D010047:Ovalbumin; D009113:Muramidase