title: Inhibition of hyperhidrosis by topical application of a local anesthetic composition.
abstract: An eutectic mixture of 5% lidocaine and 5% prilocaine applied locally to the skin inhibited epinephrine-induced sweating in healthy subjects. It also inhibited palmar and axillary hyperhidrosis from 1 to 6 hours after application to 15 of 17 patients tested. A placebo lotion was without effect. When used daily for 3--4 weeks, only 25% of the patients were very pleased with the treatment. The reason for the decrease of efficacy is uncertain.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001365:Axilla; D004338:Drug Combinations; D005260:Female; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D011318:Prilocaine / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D011318:Prilocaine; D008012:Lidocaine