Binding of thiostrepton to a complex of 23-S rRNA with ribosomal protein L11.
Thiostrepton binds with high affinity and with a 1 : 1 stoichiometry to a complex formed between Escherichia coli 23-S ribosomal RNA and ribosomal protein L11 of E. coli or the homologous protein BM-L11 of Bacillus megaterium. In the presence of T1 ribonuclease, protein BM-L11 and thiostrepton protect from degradation a fragment of E. coli 23-S RNA estimated to be about 50 nucleotides in length.
D000900:Anti-Bacterial Agents; D001410:Bacillus megaterium; D004926:Escherichia coli; D011485:Protein Binding; D012335:RNA, Ribosomal; D006163:Ribonuclease T1; D012261:Ribonucleoproteins; D012269:Ribosomal Proteins; D013883:Thiostrepton
D000900:Anti-Bacterial Agents; D012335:RNA, Ribosomal; D012261:Ribonucleoproteins; D012269:Ribosomal Proteins; D006163:Ribonuclease T1; D013883:Thiostrepton