title: [Aqueous-and serum levels of cephalexin and penicillin V after oral application in man (author's transl)].
abstract: This clinical study implies orally administered cephalexin and penicillin V as agents with effective aqueous homor penetration in noninfected human eyes. Aqueous humor concentration of cephalexin increases up to 15% of the serum level 2 h after application. Administration of 1 g or 2 g cephalexin revealed no significant difference in aqueous humor concentration.  So penetration of blood-aqueous-humor barrier can be regarded as a saturation process. Individual results of 92 cephalexin determinations are variant and not related to body weight or age of the patients.
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000032:analysis*; D002387:Cataract Extraction; D002506:Cephalexin / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010404:Penicillin V / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D002506:Cephalexin; D010404:Penicillin V
vernacular_title: Kammerwasser- und Serumkonzentration nach oraler Applikation von Cephalexin und Penicillin V beim Menschen.