title: Protection of mice against Babesia microti with cord factor, COAM, zymosan, glucan, Salmonella and Listeria.
abstract: Cord factor (trehalose 6-6' dimycolate). COAM (chlorite-oxidized oxyamylose), zymosan, glucan, Salmonella enteritidis 11RX and Listeria monocytogenes were found to protect mice against subsequent infection with Babesia microti, an intra-erythrocytic protozoan parasite. This protection was not observed after injection of Staphylococcus epidermidis, a viridans group Streptococcus, thioglycollate, or colloidal carbon. All the agents which protect against B. microti have also been reported to induce non-specific protection against experimental tumours. The parasites appear to die inside circulating red cells. This implies that these can exert non-specific protection against this parasite through the mediation of a soluble factor.
mesh_terms: D000688:Amylose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001404:Babesiosis / Q000188:drug therapy / Q000276:immunology*; D002244:Carbon / Q000627:therapeutic use; D004187:Disaccharides / Q000627:therapeutic use*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005936:Glucans / Q000627:therapeutic use; D008089:Listeria monocytogenes / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D012477:Salmonella enteritidis / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology; D013291:Streptococcus / Q000276:immunology; D013864:Thioglycolates / Q000627:therapeutic use; D014199:Trehalose / Q000627:therapeutic use*; D015054:Zymosan / Q000627:therapeutic use*
chemical_list: D004187:Disaccharides; D005936:Glucans; D013864:Thioglycolates; C002668:oxyamylose; D002244:Carbon; D000688:Amylose; D015054:Zymosan; D014199:Trehalose