[Effect of schizophrenic patients' serum immunoglobulins on nerve cell potentials].
With the aid of the microelectrode method, the influence of different protein fractions isolated from the blood serum of schizophrenic patients and normals on an edible snail was studied. The fractions were isolated by means of ion exchange chromatography and contained immunoglobulins (IgG, IgA, IgM). It was established that the fraction of the blood serum in schizophrenic patients, containing IgM is significantly stronger than the respective fraction in normals, depolarizing and inactivating the neuron membrane. It is suggested that there is an increased content of tropic to the nervous tissue antibodies of this class in the blood serum of schizophrenic patients.
D000818:Animals; D004589:Electrophoresis, Disc; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D012559:Schizophrenia / Q000097:blood* / Q000276:immunology; D012908:Snails
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins
Deĭstvie immunoglobulinov syvorotki krovi bol'nykh shizofrenieĭ na potentsialy nervnoĭ kletki.