title: Comparative metabolism and excretion of adriamycin in man, monkey, and rat.
abstract: Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D004317:Doxorubicin / Q000378:metabolism* / Q000652:urine; D005260:Female; D000882:Haplorhini; D006801:Humans; D007700:Kinetics; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D004317:Doxorubicin