title: Inhibition of histaminase release from human granulocytes by products of histaminase activity.
abstract: Imidazoleacetic acid, a product of the action of histaminase (E.C. 1.4.3.6) on histamine, inhibits specific release of histaminase from human peripheral blood granulocytes with an inhibition constant between 5 X 10(-9)M and 1 X 10(-8)M. Hence, modulation of enzyme release is indirectly mediated by the activity of the enzyme.
mesh_terms: D000085:Acetates / Q000494:pharmacology; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D001692:Biological Transport / Q000187:drug effects; D005246:Feedback; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007700:Kinetics
chemical_list: D000085:Acetates; D007093:Imidazoles; D006631:Amine Oxidase (Copper-Containing)