[Effect of nitroglycerin, digoxin and inderal of myocardial asynergy in ischemic heart disease].
The effect of nitroglycerin, digoxin and inderal on myocardial asynergy was studied in 108 patients with ischemic heart disease by means of echocardiography. The effect of nitroglycerin was studied in 32 patients; myocardial contractions were restored in the areas of asynergy in 15 patients, in 17 the character of myocardial asynergy did not change. The effect of digoxin was studied in 42 patients; intensification of myocardial contractions in the asynergic areas was noted in 18 patients in 16 the character of asynergy of the myocardium did not change, and in 8 paradoxical protrusion of the cardiac wall increased. Prescription of inderal for 34 patients did not lead to the development of additional areas of myocardial asynergy; proportionate decrease of the amplitude of the systolic myocardial movement in healthy areas and in areas with hypo-and dyskinesia was noted in such cases. The study showed changeability of the character of myocardial asynergy under the effect of the drugs investigated, which should be taken into account when these drugs are given to patients with ischemic heart disease.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy*; D004077:Digoxin / Q000627:therapeutic use*; D004341:Drug Evaluation; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy; D005996:Nitroglycerin / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
D004077:Digoxin; D011433:Propranolol; D005996:Nitroglycerin
Vliianie nitroglitserina, digokisina i inderala na asinergiuiu miokarda u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.