Non-mutagenicity for Salmonella of the chlorinated hydrocarbons aroclor 1254, 1,2,4-trichlorobenzene, mirex and kepone.
A polychlorinated biphenyl mixture, Aroclor 1254, two commercial grade insecticides, mirex and kepone, and a pesticide breakdown product, 1,2,4-trichlorobenzene were evaluated for mutagenicity and hepatic enzyme induction potential in the Salmonella/microsomal assay. None was found to revert strains TA1535, TA1537, TA98 or TA100 when tested with or without metabolic activation. Liver microsomal extracts (S9) from rats induced with 1,2,4-trichlorobenzene were shown to differ from S9 of either control or Aroclor 1254-induced rats in the capacity to activate 2-aminoanthracene mutagenesis.
D001140:Aroclors / Q000494:pharmacology*; D007631:Chlordecone / Q000494:pharmacology*; D002722:Chlorobenzenes / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D007306:Insecticides / Q000494:pharmacology*; D008917:Mirex / Q000494:pharmacology*; D009153:Mutagens; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D001140:Aroclors; D002722:Chlorobenzenes; D007306:Insecticides; D009153:Mutagens; C009947:1,2,4-trichlorobenzene; D011078:Polychlorinated Biphenyls; D007631:Chlordecone; D008917:Mirex