Inhibitory action of 6-ethyl-3-(1H-tetrazol-5-YL)chromone (AA-344) on IgE, IgGa- or chemical agent-induced histamine release from isolated rat mast cells.
The antiallergic action of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) was studied on isolated rat peritoneal mast cells. AA-344 clearly inhibited the IgE-mediated release of histamine caused by various concentrations of antigen and the 50% inhibitory concentration was 0.1 microM. On the IgGa-mediated release of histamine, a peak inhibition of AA-344 was observed at 10 microM. The histamine release induced by chemical agents such as concanavalin A, dextran and compound 48/80 was depressed by AA-344 at the range of 0.1--1 mM. The results obtained in this study indicate that the antiallergic action of AA-344 is due to selective inhibition on the immunological release of the chemical mediator from mast cells.
D000818:Animals; D002867:Chromones / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D003864:Depression, Chemical; D003911:Dextrans / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D051381:Rats; D013268:Stimulation, Chemical; D013777:Tetrazoles / Q000494:pharmacology
D002867:Chromones; D003911:Dextrans; D007074:Immunoglobulin G; D013777:Tetrazoles; D003208:Concanavalin A; D007073:Immunoglobulin E; C018537:6-ethyl-3-(1H-tetrazol-5-yl)chromone