title: Distribution and excretion in the rat and monkey of [82Br] bromocriptine.
abstract: Radiolabeled bromocriptine was administered to rats and monkeys and its tissue distribution, rate of excretion and metabolism were determined. In both species, [82Br]bromocriptine is predominantly concentrated in the liver, metabolized and then excreted through bile. Extractable free drug is undetectable in blood after 30 min. After 2 hr, the estimated concentration of free drug in rat brain is 2 x 10(-8) M. Terminal phase half-lives of radiolabel excretion were 2.9 days for the rat and 27.3 days for the monkey. The retained organically bound 82Br is present in a form more polar than bromocriptine.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001966:Bromine; D001971:Bromocriptine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006207:Half-Life; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D011868:Radioisotopes; D051381:Rats; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes; D001971:Bromocriptine; D001966:Bromine; D004298:Dopamine