title: [Relationship between aminoglucuronide synthesis in the bodies of white rats and the physico-chemical properties of the substrate].
abstract: In rats 5-substituted 2-aminobenzophenones (R-NH2; CH3; Cl) formed N-glucuronides. Amounts of free substances and of the glucuronyl-conjugates, excreted with the urine, depended on the nature of the radical; the derivatives differed in the values of Hammet's constants, in the lipophility and alkalinity. Estimation of Hammet's constants enabled to find a satisfactory correlation between the physico-chemical properties of the derivatives studied and the amounts of glucuronides excreted with urine.
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005965:Glucuronates / Q000096:biosynthesis*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001577:Benzophenones; D005965:Glucuronates; D014453:Glucuronosyltransferase
vernacular_title: Sintez aminogliukuronidov v organizme belykh krys zavisimost' protsessa ot fiziko-khimicheskikh svoistv substrata.