Effect of bradykinin on prostaglandin synthetase activity in microsomal fractions from rat duodenum and uterus.
The bioconversion of tritiated arachidonic acid by microsomal fractions from rat uterus and duodenum is described. In rat duodenum the formation of both prostaglandin E2 and F2alpha is enhanced by the peptide hormone bradykinin. In contrast, bradykinin inhibits the synthesis of PGE2 in rat uterus.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D004386:Duodenum / Q000201:enzymology*; D005260:Female; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D009928:Organ Specificity; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D051381:Rats; D014599:Uterus / Q000201:enzymology*
D011458:Prostaglandins E; D011460:Prostaglandins F; D011451:Prostaglandin-Endoperoxide Synthases; D001920:Bradykinin