title: Computed tomography in a primate stroke model using selective balloon catheter arterial occlusion.
abstract: Ten heparinized nonhuman primates (rhesus monkeys and Papio maryumaya baboons) were subjected to temporary occlusion of an insular branch of the middle cerebral artery with a balloon catheter. An infarct was created. The lesions were monitored in vivo by computed tomography performed at intervals for 1 year. Animals were sacrificed and the lesions examined histologically. The technique obviates the disadvantages of surgical reaction, intravascular thrombosis, and gross cerebral edema observed in prior animal stroke models.
mesh_terms: D000818:Animals; D002404:Catheterization; D002536:Cerebral Arteries; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D010215:Papio; D014057:Tomography, X-Ray Computed