[Isolated rat hepatocytes. Simultaneous study of variations in sialic acid content of glycoconjugated membranes and asialotransferrin uptake].
Hepatocytes isolated from streptozotocin treated Rats bind less asialotransferrin than hepatocytes isolated from normal rats. This decrease is parallel with a decrease in the sialic acid content. Insulin therapy restored simultaneously membrane sialic acid content and asialotransferrin binding capacity.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D006023:Glycoproteins / Q000494:pharmacology; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism*; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism
D001786:Blood Glucose; D006023:Glycoproteins; D007328:Insulin; D012794:Sialic Acids; D014168:Transferrin
Hépatocytes isolés de rat. Etude simultanée des variations de la teneur en acide sialique de glycocongugués membranaires et de la captation de l'asialotransferrine.