Ascaris-induced respiratory responses in the conscious rhesus monkey.
Reproducible immediate-type respiratory responses were evoked in conscious monkeys, sensitive to inhaled Ascaris suum, for periods up to 18 months. These responses were characterized by decreases in tidal volume and increases in breathing rate that persisted for about 40 min. Maximum changes were seen 3--5 min after exposure to the aerosolized antigen and were often accompanied by coughing and increased movement of the animals within the plethysmograph used for monitoring their ventilatory changes. Significant inhibition of the Ascaris-induced respiratory changes were seen in animals treated with either isoproterenol or cromolyn sodium. However, the latter agent was not effective in reversing histamine-induced ventilatory changes. The conscious monkey appears to be a suitable animal for evaluating potential antiallergic drugs.
D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology*; D004205:Cromolyn Sodium / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D000882:Haplorhini; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000276:immunology*; D008253:Macaca mulatta; D008297:Male; D013990:Tidal Volume; D013997:Time Factors
D000336:Aerosols; D000941:Antigens; D006632:Histamine; D007545:Isoproterenol; D004205:Cromolyn Sodium