Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Uridine diphosphate-galactose : glycoprotein galactosyltransferase (EC 2.4.1.22) was measured serially prior to and after surgery in 4 patients with ovarian epithelial cancer. The levels of this enzyme in the sera correlated well with the clinical status of the patients. In 2 other patients, the follow-up was designed to detect recurrence, and the enzyme assay was started when the patients were clinically disease free. Elevation of galactosyltransferase preceded the clinical appearance of disease by 3-7 months. Serial determination of glycoprotein galactosyltransferase in serum may be useful for evaluating the effectiveness of therapeutic programs.
D000230:Adenocarcinoma / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D005260:Female; D006801:Humans; D007788:Lactose Synthase / Q000097:blood*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D012008:Recurrence; D012075:Remission, Spontaneous; D013997:Time Factors
D007788:Lactose Synthase