Carcinogenicity of 4-nitrosoquinoline 1-oxide and its possible role in carcinogenesis by 4-nitroquinoline 1-oxide.
4-Nitrosoquinoline 1-oxide induced malignant tumors at the subcutaneous site of injection in mice. It affected Escherichia coli to induce the so-called UV-type lesion in cellular DNA. DNA base-quinoline adducts produced by the treatment of mammalian cellular DNA with this carcinogen were proved to be identical with those obtained by the action of 4-nitroquinoline 1-oxide. Although this carcinogen was reactive enough to modify DNA chemically by itself, a different DNA modification took place in a chemical process from thos obtained in the in vivo process.
D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D009154:Mutation / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009600:Nitroquinolines; D009603:Nitroso Compounds / Q000633:toxicity
D004269:DNA, Bacterial; D009600:Nitroquinolines; D009603:Nitroso Compounds; D015112:4-Nitroquinoline-1-oxide