title: Changes in brain dopamine, norepinephrine and serotonin associated with convulsions induced by pinealectomy in the gerbil.
abstract: In three separate experiments, adult male gerbils 10 weeks of age were pinealectomized (PX), observed for convulsions, and sacrificed at various intervals after PX. Norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in selected brain parts were determined by fluorometric procedures. No changes in DA were observed. Serotonin levels were shown to be elevated in sham-operated and PX animals, possibly due to stress phenomena associated with anesthesia or surgical procedures. Norepinephrine was significantly depressed over control and sham-operated animals by 1 hour after surgery with a post-operative duration of at least 12 hours. Results in this study did not indicate whether the decreased NE was the cause or an effect of the PX-induced convulsive activity.
mesh_terms: D000818:Animals; D001831:Body Temperature; D004298:Dopamine / Q000378:metabolism*; D005849:Gerbillinae / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010870:Pineal Gland / Q000502:physiology; D012640:Seizures / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013687:Telencephalon / Q000378:metabolism*; D013997:Time Factors
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine