title: Low molecular weight proteins as urinary markers of aminoglycoside nephrotoxicity in man.
abstract: The proteinuria of fifteen patients treated with just aminoglycoside or aminoglycoside and either penicillin or cephalosporin was studied. The proteinuria was analysed by means of immunoelectrophoresis, acetate cellulose electrophoresis, thin-layer polyacrylamide gel electrophoresis and sodium dodecylsulphate acrylamide gel electrophoresis. We observed a urinary excretion of free immunoglobulin light chains and an increased urinary excretion of lysozyme in all cases. The increase in urinary excretion of beta-2-microglobulin and retinol-binding-protein appeared only in patients treated with aminoglycoside and cephalosporin. These disturbances disappeared a few days after the treatment was discontinued.
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000009:adverse effects; D005839:Gentamicins / Q000009:adverse effects; D006801:Humans; D007147:Immunoglobulin Light Chains; D007668:Kidney / Q000187:drug effects*; D008970:Molecular Weight; D011507:Proteinuria / Q000188:drug therapy*; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D005719:gamma-Globulins
chemical_list: D000617:Aminoglycosides; D002511:Cephalosporins; D005839:Gentamicins; D007147:Immunoglobulin Light Chains; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D005719:gamma-Globulins