Genetic control of resistance to tumors.
Hybrid resistance to a BALB/c plasmacytoma, MPC-11, has been investigated. The results indicate that heterozygosity within the H-2 complex is neither necessary nor sufficient for resistance to be observed. However, in the presence of a single gene or gene complex which segregates independently of H-2, differential effects of various H-2 haplotypes can be seen. Resistance is radiation-sensitive and silica-insensitive and probably depends on active immune responses. The data also suggest that production by a hybrid of endogenous viral antigens with certain type-specific determinants shared with viral antigens expressed on the tumor may interfere with resistance. The mechanism for this is not understood but might involve tolerance, suppression, or enhancing antibody.
D000818:Animals; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006579:Heterozygote; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental; D010954:Plasmacytoma / Q000235:genetics* / Q000276:immunology