A comparison of intralingual and intravenous epinephrine before and during cardiovascular depression.
Dose-response methodology was used to evaluate the cardiopulmonary effects of epinephrine administered intravenously and intralingually to normotensive and acutely hypotensive dogs and monkeys. Results indicate that the intralingual route is much less effective than the intravenous route and that conventional doses of emergency drugs injected intralingually may not afford sufficient resuscitative effects to be lifesaving during cardiovascular depression.
D000208:Acute Disease; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004630:Emergencies / Q000188:drug therapy; D004837:Epinephrine / Q000008:administration & dosage* / Q000494:pharmacology; D000882:Haplorhini; D006632:Histamine / Q000494:pharmacology; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D012137:Respiratory System / Q000187:drug effects; D012770:Shock, Cardiogenic / Q000188:drug therapy*; D014059:Tongue
D006632:Histamine; D004837:Epinephrine