title: Diphenylhydantoin teratogenicity: ocular manifestations and related deformities.
abstract: This patient illustrates a classical case of what many pediatricians call the diphenylhydantoin teratogenic syndrome. It suggests the possibility of an additional ocular finding of retinoschisis and optic nerve abnormalities which could conceivably have a teratogenic basis. The effects of epilepsy and diphenylhydantoin on these formations is discussed.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D001763:Blepharoptosis / Q000139:chemically induced; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D005124:Eye Abnormalities; D005260:Female; D005385:Fingers / Q000002:abnormalities; D006197:Hair / Q000002:abnormalities; D006801:Humans; D006972:Hypertelorism / Q000139:chemically induced; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009900:Optic Nerve / Q000002:abnormalities; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D012163:Retinal Detachment / Q000139:chemically induced; D013285:Strabismus / Q000139:chemically induced; D014034:Toes / Q000002:abnormalities
chemical_list: D010672:Phenytoin