[Biosynthesis of penicillin upon periodic culturing of Penicillium chrysogenum with an exponentially increasing glucose supply].
Penicillium chrysogenum was cultivated under controlled conditions and at constant specific growth rates regulated by glucose supply. The rate of penicillin synthesis (units/mg dry weight.hr) and pattern of time changes of the synthesizing capacity of the culture depended on the specific growth rate (hr-1). The arrest of penicillin synthesis was induced by the inherent changes of the culture rather than by external factors, e.g. use of substrates, changed limitation, accumulation of inhibitory metabolites, etc.
D003470:Culture Media; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D010406:Penicillins / Q000096:biosynthesis*; D010408:Penicillium chrysogenum / Q000254:growth & development / Q000378:metabolism*
D003470:Culture Media; D010406:Penicillins; D005947:Glucose
Biosintez penitsillina pri periodicheskom kul'tivirovanii Penicillium chrysogenum s éksponentsial'no vozrastaiushcheĭ podacheĭ gliukozy.