[Action of polychlorinated biphenyls (Kanechlor 500 and Delor 106) and 3-methylcholanthrene on the activity of some rat liver microsomal enzymes].
The influence of 3-methylcholanthrene and two commercially available mixtures of polychlorinated biphenyls (Kanechlor 500 and Delor 106) on the activity of some microsomal rat liver enzymes has been investigated. The studies included the demethylation of ethylmorphine, dimethylnitrosamine, and 4-dimethylaminoazobenzene as well as the investigation of the activity of aryl hydrocarbon hydroxylase and of azoreductase using benzo(a)pyrene and 4-dimethylaminoazobenzene as substrates, respectively. 3-methylcholanthrene induced the aryl hydrocarbon hydroxylase and azoreductase and led to an increase in the demethylation of 4-dimethylaminoazobenzene but not in the ethylmorphine demethylation. The relatively low increase in the dimethylnitrosamine demethylation was not statistically significant. These polychlorinated biphenyls caused a significant increase in all the enzyme activities studied. In most cases Delor 106 was more active than Kanechlor 500. The results are discussed and compared with those of other authors.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats
D008748:Methylcholanthrene; D011078:Polychlorinated Biphenyls; D010088:Oxidoreductases; D001189:Aryl Hydrocarbon Hydroxylases; D010089:Oxidoreductases, N-Demethylating
Die Wirkung von polychlorierten Biphenylen (Kanechlor 500 und Delor 106) und von 3-Methylcholanthren auf die Aktivität mikrosomaler Enzyme der Rattenleber.