Intrathymic injection of antigen: a potent procedure for the induction of suppressor T cells.
Immunological tolerance is induced in mice by intrathymic injection of HSA. The tolerance thus induced is mediated by suppressor T cells. Strong tolerance persists more than 56 days after the induction, and the high efficiency of the tolerance thus induced is accounted for in terms of the number or the potentiality of suppressor cells. Possible mechanisms of suppressor T cell induction by iT injection of the antigen are discussed briefly.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D000939:Epitopes; D006801:Humans; D007108:Immune Tolerance; D007116:Immunization, Passive; D007267:Injections; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012709:Serum Albumin / Q000276:immunology; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013950:Thymus Gland; D013997:Time Factors
D000941:Antigens; D000939:Epitopes; D012709:Serum Albumin