Pulsed pattern of proliferation in liver parenchyma of young mice. Natural synchronization of DNA-synthesizing hepatocytes.
The present investigation is concerned with natural synchronization of DNA-synthesizing hepatocytes in the growing liver of young mice. It has been found that in individual specimens, 30--40% of all the parenchymal liver cells pass through the S phase within about 22 h. These cells are grouped into two large synchronous fractions, so-called "S-pulses". The time interval between the formation of these "S-pulses" is assigned by the duration of the S phase. It is shown that the maximum separate "S-pulse" involves 20% of the total hepatocyte population.
D000818:Animals; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D007399:Interphase; D008099:Liver / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D051379:Mice; D013997:Time Factors
D004247:DNA