Synthetic antigens III. Antigen-binding cells to interpolymer of styrene and maleic acid PSM and sheep red blood cells in mice immunized with PSM.
Studies on the immune response in mice to a new synthetic antigen interpolymer of styrene and maleic acid (PSM) are described. The immune response was measured by determination of antigen binding cells by means of rosette test with PSM-coated SRBC, An unexpected effect was observed--besides rosette-forming cells for PSM, rosette-forming cells and agglutinating antibodies for sheep red cells were found. The results presented in this paper suggest that PSM is acting both as an immunogen and a polyclonal B-cell activator. As a polyclonal B-cell activator, PSM might stimulate the immune response to sheep red blood cells. However, in the case of PSM, in contrast to other polyclonal B-cell activators, this response is suppressed and delayed. The suppression may be caused by suppressor T-cells generated by PSM or by blockade by PSM of antigen-binding cells and antibody-forming cells for sheep red blood cells. The mechanism of the effect observed is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D015478:Antigens, Heterophile / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D002645:Chickens; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D006736:Horses; D006801:Humans; D008298:Maleates / Q000276:immunology*; D051379:Mice; D011108:Polymers; D012397:Rosette Formation; D012756:Sheep; D013343:Styrenes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D015478:Antigens, Heterophile; D000939:Epitopes; D008298:Maleates; D011108:Polymers; D013343:Styrenes