title: A model of experimental endotoxin shock in monkeys and its therapeutic control.
abstract: The course and therapy of endotoxin shock were studied in 34 monkeys Macaca mulatta. E. coli endotoxin was infused intravenously to conscious animals. The individual responses to a dose of 3 mg . kg-1 exhibited a considerable variability. A part of shocked animals were successfully rescued by a combined infusion of dopamine, hydrocortisone, and dextran; untreated animals died of endotoxin shock. Morphological changes in their parenchymatous organs were little marked in the acute experiment.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003911:Dextrans / Q000627:therapeutic use; D004195:Disease Models, Animal; D004298:Dopamine / Q000627:therapeutic use; D004731:Endotoxins; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D000882:Haplorhini; D006854:Hydrocortisone / Q000627:therapeutic use; D008253:Macaca mulatta; D008297:Male; D012772:Shock, Septic / Q000628:therapy*
chemical_list: D003911:Dextrans; D004731:Endotoxins; D004298:Dopamine; D006854:Hydrocortisone