title: Megakaryocyte polyploidization in May-Hegglin anomaly.
abstract: Polyploidization of megakaryocytes was studied in bone marrow aspirates from 3 patients with May-Hegglin anomaly by combined application of cytophotometric determination of the DNA content and autoradiography with 3H-TdR labeling in vitro. A marked elevation of the influx of progenitor cells into the megakaryocytic cell system as well as a decreased maturation capacity from type II to type III megakaryocytes was observed possibly contributing to the pathological platelet sequestration. The polyploidization activity as assessed by 3H-TdR labeling and nuclear DNA content was normal.
mesh_terms: D000293:Adolescent; D001345:Autoradiography; D001773:Blood Cells; D001792:Blood Platelets; D002648:Child; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000235:genetics*; D006470:Hemorrhage; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000648:ultrastructure*; D008875:Middle Aged; D011123:Polyploidy
chemical_list: D004247:DNA