Altered pilocarpine- or chlorpromazine-induced catalepsy after long-term treatment with cholinergic drugs.
Long-term administration of the cholinergic drug pilocarpine attenuates the catalepsy induced by an acute injection of pilocarpine or the deopamine antagonist chlorpromazine. Similar results (i.e., tolerance to pilocarpine and cross-tolerance to chlorpromazine) were noted in mice chronically treated with the cholinesterase inhibitor physostigmine but not in mice chronically treated with neostigmine, a cholinesterase inhibitor which does not penetrate the central nervous system. Mice maintained on the anticholinergic scopolamine showed the opposite effect; there was an increase in the sensitivity to the catalepsy induced by pilocarpine or chlorpromazine. The results suggest that long-term changes in cholinergic receptors may indirectly alter the behavioral effects of drugs which act via dopamine.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D002746:Chlorpromazine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051379:Mice; D009388:Neostigmine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D010862:Pilocarpine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D010277:Parasympathomimetics; D010862:Pilocarpine; D009388:Neostigmine; D012601:Scopolamine; D002746:Chlorpromazine