Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells.
Until now the interferon-mediated 2'-5' adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.
D000227:Adenine Nucleotides / Q000502:physiology*; D000818:Animals; D002474:Cell-Free System; D004686:Encephalomyocarditis virus / Q000254:growth & development; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells / Q000382:microbiology; D051379:Mice; D009841:Oligonucleotides / Q000502:physiology*; D009843:Oligoribonucleotides / Q000502:physiology*; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects*
D000227:Adenine Nucleotides; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; C023505:2',5'-oligoadenylate; D007372:Interferons