title: [Interactions of platelet inhibitors].
abstract: Combination effects of inhibitors of platelet function with different mechanisms of action such as adenosine, acetylsalicylic acid, papaverine, dipyridamole, and sodium nitroprusside were studied in vitro by means of ADP- and collagen-induced aggregation of human blood platelets. In case of ADP-induced aggregation, potentiation of the inhibitory effect was observed only with the combination adenosine-papaverine, whereas in case of collagen-induced aggregation the inhibitory effect was potentiated at various inhibitor combinations.
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004347:Drug Interactions; D006162:Guanylate Cyclase / Q000494:pharmacology; D006801:Humans; D009701:Nucleoside-Diphosphate Kinase / Q000494:pharmacology; D010105:Oxygenases / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010741:Phospholipases A / Q000494:pharmacology; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D013930:Thromboxane-A Synthase / Q000494:pharmacology
chemical_list: D004176:Dipyridamole; D010208:Papaverine; D010105:Oxygenases; D009701:Nucleoside-Diphosphate Kinase; D010741:Phospholipases A; D010727:Phosphoric Diester Hydrolases; D006162:Guanylate Cyclase; D013930:Thromboxane-A Synthase; D000241:Adenosine; D001241:Aspirin
vernacular_title: Kombinationswirkung von Plättchenhemmstoffen.