Stimulation of cell-mediated resistance in mice to infection with Listeria monocytogenes by vitamin A.
Vitamin A given as retinol-acetate, retinol-palmitate as well as the derivates retinoic acid and a retinoid, strongly fortified the resistance of mice to infection with virulent cells of Listeria monocytogenes. However, strong enhancement of resistance was only achieved when high toxic doses of vitamin A were given. Apparently, this effect was due to a stimulation of the function of the mononuclear phagocytic system rather than of the T lymphocyte.
D000818:Animals; D005050:Etretinate / Q000494:pharmacology; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D008089:Listeria monocytogenes / Q000302:isolation & purification; D008088:Listeriosis / Q000276:immunology*; D051379:Mice; D013154:Spleen / Q000382:microbiology; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D005050:Etretinate