Regulation of the in vivo immune response to an autologous red blood cell antigen (Hb) by prostaglandins.
Mice treated with inhibitors of prostaglandin synthetase showed an alteration in the number of spontaneous, anti-autologous erythrocyte antigen (Hb)-antibody-forming cells in the spleens. The number of anti-Hb plaque-forming cells and rosette-forming cells in the peritoneum of mice treated with inhibitors of prostaglandin synthesis was regulated depending on a magniture of the response in the individual experiments. Depletion of T cells after the antithymocyte treatment of animals resulted in a significant diminution of the regulatory action of the prostaglandin synthetase inhibitor. The results indicate that prostaglandins are involved in the regulation of the in vivo anti-Hb autoimmune response mediating the regulatory cell action.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D000941:Antigens / Q000276:immunology*; D001202:Ascitic Fluid / Q000166:cytology; D001323:Autoantibodies / Q000096:biosynthesis*; D001324:Autoantigens / Q000276:immunology*; D016861:Cyclooxygenase Inhibitors; D004912:Erythrocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D051379:Mice; D011453:Prostaglandins / Q000378:metabolism*; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins