Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency.
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003565:Cytidine Diphosphate / Q000378:metabolism; D003841:Deoxycytidine / Q000378:metabolism; D003845:Deoxycytosine Nucleotides / Q000378:metabolism; D003849:Deoxyguanosine / Q000633:toxicity*; D007042:Hypoxanthines / Q000494:pharmacology; D007165:Immunosuppression Therapy; D010084:Oxidation-Reduction; D010430:Pentosyltransferases / Q000172:deficiency*; D011684:Purine Nucleosides / Q000633:toxicity; D011683:Purine-Nucleoside Phosphorylase / Q000172:deficiency*; D012265:Ribonucleotides / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects*; D014529:Uridine / Q000494:pharmacology
D003845:Deoxycytosine Nucleotides; D007042:Hypoxanthines; D011684:Purine Nucleosides; D012265:Ribonucleotides; D003841:Deoxycytidine; D003565:Cytidine Diphosphate; D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D003849:Deoxyguanosine; D014529:Uridine