title: Multiple myeloma without detectable Ig synthesis.
abstract: A case of nonproductor myeloma is reported. The diagnosis was supported by the radiological findings, the heavy marrow infiltration of malignant plasma cells, the absence of a monoclonal component in the serum or urine and the failure to demonstrate intracytoplasmic immunoglobulins with immunoifluorescent techniques. The clinical findings of our patient are similar to those reported for the 5 cases of nonproductor myeloma described so far, indicating that there are no characteristic features differentiating nonproductor myeloma from productor myelomas.
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology; D010014:Osteolysis; D010950:Plasma Cells / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging
chemical_list: D007136:Immunoglobulins; D008558:Melphalan; D011241:Prednisone