High-affinity binding of beta-alanine to cerebral synaptosomes might involve glycine-receptors.
High-affinity, Na+-independent binding of beta-alanine to a synaptosomal fraction of rat brain was potently inhibited by glycine and by some other alpha-amino acids, but not by taurine or GABA. This binding mechanism, which was also sensitive to both bicuculline and strychnine, might involve synaptic receptors for both beta-alanine and glycine.
D000409:Alanine / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism; D015091:beta-Alanine / Q000378:metabolism*
D000596:Amino Acids; D011955:Receptors, Drug; D015091:beta-Alanine; D000409:Alanine; D005998:Glycine