Uterine contractility and plasma levels of steroid hormones after intravaginal treatment of pregnant Japanese monkeys (Macaca fuscata fuscata) with 16,16-dimethyl-trans-delta2-prostaglandin E-1 methyl ester.
Intravaginal treatment with a PGE-1 analogue (ONO-802) resulted in strong uterine contractions with a high frequency which lasted for more than 3 h. When 20-50 microgram ONO-802/kg were administered intravaginally 5 times every 3 h in 5 pregnant animals, vaginal bleeding started by 6 h and abortion occurred by 26 h after the initial treatment. There were no significant side effects. Plasma levels of steroid hormones, especially progesterone and 20alpha-dihydroprogesterone, fluctuated initially and then finally dropped to undetectable levels within 24 h.
D000028:Abortion, Induced; D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D000882:Haplorhini; D008251:Macaca; D009215:Myometrium / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D012739:Gonadal Steroid Hormones; D011459:Prostaglandins E, Synthetic; D011374:Progesterone; D004958:Estradiol