Some cellular changes associated with triton WR-1339 accumulation in rat hepatocytes.
Electron microscopic morphological and cytochemical techniques were used to follow the sub-cellular events that accompanied Triton WR-1339 accumulation in hepatocytes. Localization of two lysosomal enzymes, acid phosphatase and aryl sulfatase, clearly established the lysosomal nature of the Triton WR-1339 containing electron-lucid structures that appear in hepatocytes following treatment with this compound.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001192:Arylsulfatases / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008854:Microscopy, Electron; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats
D011092:Polyethylene Glycols; D000135:Acid Phosphatase; D001192:Arylsulfatases