title: Immunological features and corticosteroid therapy of midline granuloma.
abstract: This paper presents treatment of midline granuloma with corticosteroids and immunological features of this disease. The cellular immunity state of this patient was examined by counting T cell subpopulation and lymphocyte blastformation index (BI) by phytohemagglutinin at various time intervals during the corticosteroid therapy. Consequently, the percentage of T cells and BI became greatly increased according to the subsiding of the primary lesion, whereas non-T cell production and its function were depressed. In this communication we discuss a possible autoantibody mechanism and impared lymphocyte transformation in midline granuloma.
mesh_terms: D002610:Cheek; D006103:Granuloma, Lethal Midline / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D011859:Radiography; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011239:Prednisolone