Tumor-induced immunosuppression.
Three tumor systems, including a mastocytoma, plasmacytomas, and a leukemia-lymphoma were studied for their ability to modify humoral immunity to sheep erythrocytes both in vivo and in vitro. All tumors resulted in a depression of the hemolytic antibody plaque-forming cell response in susceptible mice. These studies indicated that the mechanism(s) of suppression, although not fully defined, were different for each model system investigated.
D000818:Animals; D000917:Antibody Formation; D002460:Cell Line; D002474:Cell-Free System; D005622:Friend murine leukemia virus; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000032:analysis; D007942:Leukemia, Experimental / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology*
D007166:Immunosuppressive Agents