Involvement of central cholinoceptors in Metrazol-induced convulsions.
Atropine sulphate (10 mg/kg IP) afforded 90% protection against clonic convulsions induced by standard doses of metrazol (80 mg/kg SC) in mice, whereas atropine methonitrate (10 mg/kg IP) did not offer any protection. Furthermore, physostigmine (1 mg/kg IP) caused recurrence of convulsions in atropinzed metrazol-treated mice and converted the subconvulsive dose of metrazol (40 mg/kg SC) into a 100% convulsive dose. However, neostigmine (1 mg/kg IP) did not antagonize the protection afforded by atropine sulphate against metrazol. The results of the study suggest an involvement of central cholinergic mechanisms in metrazol-induced convulsions.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D005260:Female; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D009388:Neostigmine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D009388:Neostigmine; D008464:Mecamylamine; D001285:Atropine; D010830:Physostigmine; D010433:Pentylenetetrazole