[Comparative oxidation of erucic and oleic acids by mitochondria isolated from heart auricle of living man].
Mitochondria were isolated from fragments of heart auricles, that were cut off during surgical intracardiac operations. They were incubated with either [14 14C] erucic acid or [10 14C] oleic acid as a control. In the experimental conditions used, the radioactive products soluble in perchloric acid, that are issued from the beta-oxidation reactions in mitochondria, were formed in much lower amounts from erucic acid than from oleic acid. These results show the very low capacity of human heart mitochondria to use directly erucic acid as a substrate for energy requirements, as has been observed before with other animal species. Activation of fatty acids, the preliminary step of their beta-oxidation, was also observed to be very much lower with erucic acid.
D000328:Adult; D006348:Cardiac Surgical Procedures; D002458:Cell Fractionation; D002648:Child; D004734:Energy Metabolism; D004883:Erucic Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006325:Heart Atria / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000378:metabolism*; D009829:Oleic Acids / Q000378:metabolism*; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D004883:Erucic Acids; D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids
Oxydation comparée des acides érucique et oléique par les mitochondries isolées du myocarde auriculaire d'Homme vivant.