Strain differences in rat liver (UDP-glucuronyltransferase activity towards androsterone.
Male Donryu, Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049--0.080 nmole of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335--0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.
D000738:Androsterone / Q000378:metabolism; D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D005615:Freezing; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009596:Nitrophenols / Q000378:metabolism; D010635:Phenolphthaleins / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013739:Testosterone / Q000378:metabolism
D009596:Nitrophenols; D010635:Phenolphthaleins; D013739:Testosterone; D000738:Androsterone; D014453:Glucuronosyltransferase; D001663:Bilirubin