Gamma hydroxybutyrate in the monkey. IV. Dopaminergic mechanisms.
The electrical seizure activity and trancelike state induced in the rhesus monkey by gamma-hydroxybutyrate (GHB) were abolished by dextroamphetamine. Dextroamphetamine blockade of this neurophysiologic effect was overcome with chlorpromazine, a dopamine receptor blocker. These results suggest that the electroencephalographic (EEG) and behavioral effects of GHB are related to effects on dopaminergic systems. Such a relationship, if substantiated by further studies, might indicate that anticonvulsant drugs used to treat petit mal epilepsy have a dopaminergic mode of action.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004569:Electroencephalography; D000882:Haplorhini; D006885:Hydroxybutyrates; D008253:Macaca mulatta; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology
D006885:Hydroxybutyrates; D003913:Dextroamphetamine; D004298:Dopamine