[The role of maternal parathyroids and vitamin D3 metabolites in fetal growth and the deposition of glycogen reserves in the maternal and fetal liver in rats].
Thyro-parathyroidectomy of pregnant Rats at 12.5 days of gestation decreased maternal liver glycogen on 21.5 days of gestation and fetal weight as well as fetal liver glycogen stores. The graft of one parathyroid gland or the injection of 1 alpha-hydroxycholecalciferol in these thyro-parathyroidectomized mothers increased their liver glycogen stores at 21.5 days of gestation. These treatments also markedly increased both fetal weight and fetal liver glycogen stores. It was concluded that maternal 1,25-dihydorxycholecalciferol, which is synthesized under the control of parathyroid hormone secretion, controls fetal growth and liver glycogen stores. The mechanism of these effects (direct or indirect) requires further investigations.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000097:blood; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008099:Liver / Q000196:embryology*; D008112:Liver Glycogen / Q000378:metabolism*; D010280:Parathyroid Glands / Q000502:physiology*; D010710:Phosphates / Q000097:blood; D011247:Pregnancy; D051381:Rats
D001786:Blood Glucose; D006887:Hydroxycholecalciferols; D008112:Liver Glycogen; D010710:Phosphates; D002118:Calcium
Rôle des parathyroïdes maternelles et des métabolites de la vitamine D3 dans la croissance foetale et la mise en réserve du glycogène dans le foie maternel et foetal chez le Rat.