[Endocrinological effects of substituted orthoveratramides].
The substituted orthoveratramides, derived from the orthopramides by the addition of a second methoxy radical at position 3 in the benzene ring, possess strong endocrinological effects. In particular the N[(allyl-1 pyrrolidinyl-2) methyl] dimethoxy-2-3 sulfamoyl-5 benzamide blocks oestrus in the Rat at doses considerably lower than sultopride and inhibits so-called "castration cell" formation in the pituitary.
D000818:Animals; D002369:Castration; D004971:Estrus / Q000187:drug effects*; D005260:Female; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D011759:Pyrrolidines
Recherches sur les effets endocriniens des orthovératramides substitués.