Double blind comparison of meglumine iotroxate (Biliscopin), meglumine iodoxamate (Endobil), and meglumine ioglycamate (Biligram).
Two new intravenous cholegraphic agents, iotroxate and iodoxamate, hold a lower general toxicity, lower protein binding, and claim a higher rate of biliary excretion. Both compounds proved to be equally effective in opacifying the gallbladder and the bile ducts in a double-blind clinical study comprising 400 cases. Iotroxate gave significantly earlier good or adequate visualization as a result of its higher excretion rate by the liver (P less than 0.05). Side effects were observed in fewer patients in the iotroxate group (11.6%) compared with the iodoxamate group (16.4%, P greater than 0.05). In a second double-blind study, an iotroxage group of 97 patients who received two thirds of the overall content of iodine (3.6 g) was compared with a group of 98 patients, who received ioglycamate (5.3 g). Visualization was equal in the two groups, while side effects were significantly reduced to 10.3% in the iotroxate group against 20.4% (P less than 0.05). The higher biliary clearance of iotroxate permits a reduction of the amount of iodine.
D000328:Adult; D002758:Cholangiography / Q000379:methods*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007458:Iodipamide / Q000009:adverse effects / Q000031:analogs & derivatives*; D007463:Iodobenzoates; D007471:Ioglycamic Acid / Q000009:adverse effects; D008536:Meglumine / Q000009:adverse effects; D011856:Radiographic Image Enhancement; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000009:adverse effects
D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D008536:Meglumine; D007471:Ioglycamic Acid; D007458:Iodipamide