The effect of mazindol on metabolic and regulatory changes in obese women during weight reduction.
The effect of mazindol (1 mg/day) on some metabolic and regulatory values was investigated in ten adult obese women and compared with the same number of controls during weight reduction in hospital (a five-times repeated cycle of 5 days complete starvation and 3 days on a 500 kcal(2.1MJ/day diet.) Mazindol caused a rise of hydroxyacyl CoA dehydrogenase in striated muscle by 70 per cent and a marked decline in malic dehydrogenase. Mazindol also produced higher levels of non-esterified fatty acids--significantly higher during the fifth starvation period; a small decrease in blood glucose, IRI and glucose/IRI ratio being unaffected, a significantly two-fold greater decrease of serum cholesterol; a significant increase of the noradrenaline elimination compared with a decrease in controls and in increase in triiodothyronine binding globulin towards the upper range of normal.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D004038:Diet, Reducing; D004734:Energy Metabolism; D004837:Epinephrine / Q000652:urine; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008454:Mazindol / Q000494:pharmacology* / Q000627:therapeutic use; D009132:Muscles / Q000201:enzymology; D009638:Norepinephrine / Q000652:urine; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007211:Indoles; D007328:Insulin; D014284:Triiodothyronine; D008454:Mazindol; D013974:Thyroxine; D009638:Norepinephrine; D004837:Epinephrine