Genetic control of the immune response to mammalian chymotrypsins in mice. II. The immune response to low doses of bovine alpha-chymotrypsin.
The immune response to the antigen bovine pancreatic alpha-chymotrypsin was investigated in ten recombinant strains of mice. Using a fixed antigen-percentage bound isotope technique, it was found that the quantity of antibody produced was related to the H-2 haplotype of the responding animal. A continuous distribution for the mean antibody responses was obtained for the ten strains of mice. High responsiveness was associated with the H-2 haplotype gamma2. The genetic control of the immune response to this immunogen was found to be both quantitative and qualitative.
D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D002918:Chymotrypsin / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005802:Genes, MHC Class II; D005838:Genotype; D007156:Immunologic Memory; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology; D011817:Rabbits
D002918:Chymotrypsin