Adjuvant arthritis in young copper-deficient rats.
Adjuvant arthritis has been studied in young copper-deficient rats and a very strong inhibition of the disease following 60 days of deficient diet (0.4 ppm of copper) was found. No difference in lung prostaglandin synthesis and in rat stomach strip and colon reactivity to exogenous prostaglandins was noticed between controls and copper-deficient animals. These results are briefly discussed.
D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000378:metabolism / Q000503:physiopathology*; D001835:Body Weight; D003300:Copper / Q000097:blood / Q000172:deficiency*; D005260:Female; D066298:In Vitro Techniques; D008168:Lung / Q000201:enzymology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D003300:Copper; D011451:Prostaglandin-Endoperoxide Synthases