Effects of levamisole on the immune responses of experimentally malnourished rats.
Levamisole (Ketrax), and anthelmintic drug commonly used in the tropics, has been found to restore the impaired spontaneous rosette-forming lymphocytes and delayed cutaneous hypersensitivity reactions in experimentally malnourished rats. It, however, has no effects on plaque-forming cells. The drug was also found to reconstitute the histologic integrity of the thymus in malnutrition.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002478:Cells, Cultured; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D007958:Leukocyte Count; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011502:Protein-Energy Malnutrition / Q000276:immunology*; D051381:Rats; D012397:Rosette Formation; D012867:Skin / Q000276:immunology; D013154:Spleen / Q000473:pathology; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000473:pathology
D007978:Levamisole