title: [Artherogenesis. Experimental investigations on the pathogenesis of obliterating arteriopathies in mini-pigs (author's transl)].
abstract: The principal objective of our experiments was to obtain information on the initial processes involved in the pathogenesis of obliterating arteriopathies or arteriosclerosis. We thereby concentrate on the formal pathogenesis, which we intend to elucidate by discussing the basic data and with preliminary radioimmunoassay examinations using angiopathy-models on the mini-pig. Very early in artherogenesis, an adhesion of thrombocytes in viscous metamorphose to the apparently intact arterial walls is always detectable and is followed by the formation of an intima-plaque.
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000209:etiology*; D001158:Arteries / Q000648:ultrastructure; D002248:Carbon Monoxide / Q000009:adverse effects; D002791:Cholesterol, Dietary; D003080:Cold Temperature; D004837:Epinephrine / Q000009:adverse effects*; D005227:Fatty Acids / Q000009:adverse effects; D006977:Hypertension, Renal / Q000150:complications; D010973:Platelet Adhesiveness; D012907:Smoking; D013552:Swine
chemical_list: D002791:Cholesterol, Dietary; D005227:Fatty Acids; D002248:Carbon Monoxide; D004837:Epinephrine
vernacular_title: Atherogenese. Experimentelle Untersuchungen zur Pathogenese obliterierender Arteriopathien am Miniaturschwein.