Inhibition of diamine oxidase by antihistaminic agents and related drugs.
Various drugs were tested as inhibitors of diamine oxidase on the basis of chemical relationships to the enzyme substrates. It was found that serotonine tryptamine and phenformin are good competitive inhibitors while cimetidine and pheniprazine are non-competitive inhibitors. Other antihistaminic drugs like promethazine are less powerful inhibitors.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000588:Amines / Q000494:pharmacology; D000818:Animals; D006146:Guanidines / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology*; D006834:Hydrazines / Q000494:pharmacology; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D013552:Swine
D000588:Amines; D006146:Guanidines; D006633:Histamine Antagonists; D006834:Hydrazines; D006631:Amine Oxidase (Copper-Containing)