Induction of interferon and radioprotective activity of polyriboguanylic-polyribocytidylic acid complex in mice.
The effect of polyriboguanylic-polyribocytidylic acid complex was investigated against acute X- and prolonged 60Co-gamma irradiation. Prophylactic administration of the polyribonucleotide complex increased endogenous spleen colony formation and the percentage of survival of irradiated BALB/c mice. The most pronounced effect was observed when the animals had been irradiated at the time of maximum interferon accumulation in blood, i.e. 24 hr after interferon induction by the polyribonucleotide complex.
D000818:Animals; D003114:Colony-Forming Units Assay; D005260:Female; D005720:Gamma Rays; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011066:Poly C / Q000494:pharmacology*; D011068:Poly G / Q000494:pharmacology*; D011131:Polyribonucleotides / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D014965:X-Rays
D011131:Polyribonucleotides; D011837:Radiation-Protective Agents; D011068:Poly G; D011066:Poly C; D007372:Interferons