Influence of exchange volume and dialysate flow rate on solute clearance in peritoneal dialysis.
To find the ideal dialysate flow rate and exchange volume for use in long-term peritoneal dialysis, 10 patients were studied over a period of 1.5 yr. Exchange volumes of 1 or 2 liters and dialysate flow rates of 1, 2, 3, 4, and 6 liters/hr were tested. Dextrose concentration remained constant at 1.5 g/100 ml. Peritoneal clearances for BUN, creatinine, and uric acid were calculated at 2, 5, 10, 15, and 20 hr during dialysis making a total of 120 clearances for each patient. All patients used a reverse osmosis automatic machine. The clearance of all three solutes tended to be higher with exchange volumes of 2 liters than they did with 1 liter; this trend was significant for BUN (P less than 0.025) and uric acid (P less than 0.025) but not for creatinine. There was a significant rise in clearance with increasing flow rates per hour for all solutes as shown in the following table. (Formula: see text), Since patients could not tolerate a flow rate of 6 liters/hr, we conclude that flow rate of 4 liters/hr with a 2-liter exchange will give maximum efficiency.
D001786:Blood Glucose; D001806:Blood Urea Nitrogen; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D005260:Female; D005947:Glucose; D006801:Humans; D008134:Long-Term Care / Q000379:methods; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D010710:Phosphates; D014527:Uric Acid; D003404:Creatinine; D005947:Glucose; D011188:Potassium