Total synthesis of ceramide trihexoside accumulating with Fabry's disease.
We report the synthesis of natural ceramide trihexoside, viz. gal (alpha-1 leads to 4) gal (beta-1 leads to 4) gluc (beta-1 leads to 1) ceramide (XIII). It involves the Koenigs-Knorr reaction of the bromide II with the aglucon XIX, and of the chloride VII with the D-enantiomer of the ceramide ester XII. A positional isomer of XIII was obtained as a by-product. A novel technique in the Koenings-Knorr reaction is described.
D000795:Fabry Disease / Q000378:metabolism*; D006028:Glycosphingolipids / Q000138:chemical synthesis*; D006801:Humans; D014281:Trihexosylceramides / Q000138:chemical synthesis* / Q000378:metabolism
D006028:Glycosphingolipids; D014281:Trihexosylceramides