title: [Gonadostatin and gonadocrinin, polypeptides of ovarian origin with hypophysiotropic activity].
abstract: Crude acetic acid extract of Rat ovaries pretreated with pregnant mare serum (PMSG) contains native peptides with two types of separable biological activities: one, molecular weight greater than 10,000 dalton inhibits the secretion of both LH and FSH as stimulated by luteinizing hormone releasing factor (LRF) in a pituitary monolayer culture system and is referred to as gonadostatin; the other, less than 3,500 dalton, stimulates the secretion of gonadotropins and is designated as gonadocrinin. The biological activities of ovarian gonadocrinin can be competitively inhibited by an LRF-analog-antagonist, D-Phe2, D-Trp6-LRF. These ovarian peptides may participate in physiological control of pituitary LH/FSH secretion.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology*; D010902:Pituitary Gland / Q000378:metabolism*; D010905:Pituitary Hormone Release Inhibiting Hormones / Q000302:isolation & purification / Q000494:pharmacology*; D010906:Pituitary Hormone-Releasing Hormones / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D006064:Gonadotropins, Equine; D010455:Peptides; D010905:Pituitary Hormone Release Inhibiting Hormones; D010906:Pituitary Hormone-Releasing Hormones; D007987:Gonadotropin-Releasing Hormone; C025658:LHRH, Phe(2)-Trp(6)-; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Gonadostatine et gonadocrinine, polypeptides d'origine ovarienne à activités hypophysiotropes.