title: IgA anti-dextran B1355 responses.
abstract: Injection of mice bearing the Ig-1a allotype with dextran B1355 results in an IgM antibody response that is generally regarded as thymus independent. Moreover, the antibody is directed to alpha[1,3] determinants on dextran B1355 and shares cross-reacting idiotypic determinants with a lambda 1 IgA (J558) myeloma protein as well as a lambda 1 IgM (MOPC 104E) myeloma protein. In this study, we show that BALB/c (Ig-1a) mice injected with dextran B1355 produced highly significant IgA anti-dextran responses with specificity directed to the alpha[1,3] epitope. Kinetics of the IgA anti-dextran response in BALB/c mice paralleled kinetics of the IgM response. However, the magnitude of the IgA response was markedly T cell dependent and age dependent.
mesh_terms: D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001667:Binding, Competitive; D003911:Dextrans / Q000276:immunology*; D005260:Female; D007106:Immune Sera / Q000494:pharmacology; D007070:Immunoglobulin A / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D007148:Immunoglobulin mu-Chains / Q000276:immunology; D007156:Immunologic Memory; D007700:Kinetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D003911:Dextrans; D007106:Immune Sera; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007148:Immunoglobulin mu-Chains