[Effect of nitroglycerin and sodium nitrite on myocardial mitochondrial respiration and oxidative phosphorylation normally and in coronarogenic ischemia].
The effect of nitroglycerin and sodium nitrite (2.10(-6), 2.10(-5) and 2.10(-4) g/ml) on respiration and oxidative phosphorylation of mitochondria of the normal and ischemized dog myocardium has been investigated in the presence of glutamate, succinate and alfaketoglutarate. The drugs inhibited ADP-activated oxygen consumption and ADP phosphorylation rate upon oxidation of succinic acid formed in mitochondria from exogenic glutamate, without changes in the phosphorylation coefficient and free oxidation rate (i. e. in the absence of ADP) in mitochondria of the healthy and ischemic heart. In the ischemic area one can also observe an inhibition of ADP-activated oxidation of endogenic succinate formed from exogenic glutamate.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D003864:Depression, Chemical; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects*; D009573:Nitrites / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000627:therapeutic use*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D012977:Sodium Nitrite / Q000627:therapeutic use*
D009573:Nitrites; D005996:Nitroglycerin; D012977:Sodium Nitrite
Vliianie nitroglitserina i nitrita natriia na dykhanie i okislitel'noe fosforilirovanie mitokhondriĭ miokarda v norme i pri koronarogennoĭ ishemii.