[Transplacental penetration of 7,12-dimethylbenz(a)anthracene and its distribution in the organs of rat fetuses].
Rats were given 7,12-dimethylbenz(a)anthracene (DMBA) intravenously in a dose of 15 mg/kg on the 21st day of pregnancy; its content in the liver, placenta, and the fetus was determined by the fluorescent-spectral method. The maximal concentration was reached in 10--15 min in the liver and placenta of the pregnant rats (45 and 6.3 microgram/kg, respectively) in comparison with a slower (in one hour) elevation in the fetal tissues (2.4 microgram/kg). It took about 5 hours for all the tissues to be cleared of the carcinogen. One hour after the administration DMBA was unevenly distributed in various fetal organs--the maximal content in the liver, and the minimal--in the "carcass" in comparison with the content in other organs (the kidneys, lungs, brain, intestine). The results obtained failed to correlate with the data on the predominant origination of the tumours in the kidneys and the nervous system of rats in transplacental DMBA action.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D001932:Brain Neoplasms / Q000139:chemically induced; D005260:Female; D005333:Fetus / Q000378:metabolism; D007680:Kidney Neoplasms / Q000139:chemically induced; D008431:Maternal-Fetal Exchange; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene
Osobennosti transplatsentarnogo proniknoveniia 7,12-dimetilbenz(a)antratsena i ego raspredeleniia v organakh ploda u krys.