Malignant melanoma of the choroid in neurofibromatosis.
A 60-year-old white woman with generalized neurofibromatosis and multiple melanocytic hamartomas of the iris developed an unusual choroidal mass, with secondary sensory retinal separation in the left eye. Ophthalmoscopically the tumor had a peculiar donut configuration that was caused by a large focus of central necrosis within a spindle B melanoma.
D002830:Choroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005134:Eye Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D007498:Iris / Q000473:pathology; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009456:Neurofibromatosis 1 / Q000150:complications*; D012163:Retinal Detachment / Q000150:complications; D012878:Skin Neoplasms / Q000150:complications*