Electron microscopy of cellular immunity reactions in B-cell deprived rabbits. Thymus derived antigen reactive cells, their micro-environment and progeny in the lymph node.
Three times sublethal total body X-irradiation with thymus shielding--at 14 days' intervals--established an 'isolated T-cell system'. Cellular immunity reactions in draining lymph nodes of rabbits have been analyzed at the ultrastructural level after challenge with horse spleen ferritin, the chemical sensitizer, 2-phenyl-4-ethoxymethylene-5-oxazolone and after skin allografting. A basic pattern of interdigitating cells (IDC) is described as a specific constituent of the thymus-dependent areas of peripheral lymphoid tissue. Their ultrastructural features and presumable functional relationship to the afferent loop of cellular immunity reactions are presented. The differentiation pathway of two T-cell lines is shown and discussed in relation to cellular and thymus-dependent humoral immunity reactions.
D000818:Animals; D002454:Cell Differentiation; D005293:Ferritins; D006736:Horses; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010081:Oxazolone; D011817:Rabbits; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000648:ultrastructure; D013950:Thymus Gland; D014184:Transplantation, Homologous
D010081:Oxazolone; D005293:Ferritins