Effects of 2-deoxy-D-glucose on the contraction frequency of the isolated atria from fed and fasted rats.
The mere exogenous substrate removal did not change the contraction frequency of the isolated rat atria. However, addition of 2-deoxy-D-glucose together with the glucose removal, elicited a decrease in the atrial frequency. This decrease was significantly greater in the atria from fed rats with respect to those from fasted rats. Near the end of the experiments, only in the atria from fed rats, transient irregular beating appeared. The results suggest that triglycerides constitute the major endogenous substrate of the sinus node pacemaker cells when rats have been previously fasted and that these cells have metabolic features similar to those of contractile fibres.
D000818:Animals; D016275:Atrial Function; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005215:Fasting; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D007700:Kinetics; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats
D003837:Deoxy Sugars; D003847:Deoxyglucose; D005947:Glucose