title: Long-term treatment of subjects with borderline glucose tolerance.
abstract: Subjects with borderline glucose tolerance are at a higher risk of suffering and dying from cardiovascular disease than subjects with normal glucose tolerance. Our data on the progression to overt diabetes and our data on cardiovascular morbidity and mortality suggests that tolbutamide treatment reduces these risks. In any case, we have no data supporting the theory that tolbutamide promotes cardiovascular damage.
mesh_terms: D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003927:Diet, Diabetic; D005951:Glucose Tolerance Test; D005990:Glycerol / Q000097:blood; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D008134:Long-Term Care; D011236:Prediabetic State / Q000503:physiopathology / Q000628:therapy*; D012907:Smoking; D014044:Tolbutamide / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D014044:Tolbutamide; D005990:Glycerol