[Macrophage enhancement of the immunogenicity of a suboptimal dosage of antigen-antibody complex].
Dawley mice were immunized with rabbit gamma globulin combined with allotypical antibodies, introduced alone or after preliminary incubation with syngeneic macrophages. Enhanced immune response was observed in the rats immunized both with low (0.11 mg) and high (1.1 mg) doses of the antigen with macrophages. A conclusion was made that this enhanced response had no connection with the elimination of the excess antigen by the macrophages.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D004306:Dose-Response Relationship, Immunologic; D006388:Hemagglutinins / Q000032:analysis; D007114:Immunization; D007126:Immunoglobulin Allotypes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D011817:Rabbits; D051381:Rats; D005719:gamma-Globulins / Q000276:immunology
D000936:Antigen-Antibody Complex; D006388:Hemagglutinins; D007126:Immunoglobulin Allotypes; D005719:gamma-Globulins
Usilenie makrofagami immunogennosti suboptimal'noi dozy kompleksa antigen-antitelo.