The pharmacology of diclofenac sodium (Voltarol).
Diclofenac is a potent anti-inflammatory and analgesic compound with good antipyretic and uricosuric properties. It is one of the most potent inhibitors of prostaglandin synthetase known. It shows a favourable therapeutic ratio considering its efficacy, and proved superior to the reference drugs in terms of gastro-intestinal tolerability. All metabolites are clearly less potent than the parent compound.
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000188:drug therapy; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D014528:Uricosuric Agents
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D010648:Phenylacetates; D014528:Uricosuric Agents; D004008:Diclofenac