Rosette formation of human null lymphocytes with Rhesus monkey erythrocytes.
Human null lymphocytes which lack B- and T-lymphocyte markers were found to form spontaneous rosettes with uncoated Rhesus monkey erythrocytes. Rosette-forming null lymphocytes were determined in null lymphocyte-enriched preparations of healthy persons and of patients with lymphoproliferative diseases. Quantitative determinations of these rosette-forming lymphocytes and other cells bearing B- or T-cell markers showed that some, and not all, of the null lymphocytes possess this rosette-forming capacity. The possibility of these null lymphocytes being related to T lymphocytes, but at a different cellular stage, is discussed.
D000818:Animals; D002965:Classification; D004912:Erythrocytes / Q000276:immunology; D000882:Haplorhini; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology; D012397:Rosette Formation