title: Preliminary experience with the pH-triggered pacemaker.
abstract: A cardiac pacemaker capable of responding to blood acidosis by change in its stimulation rate allows adjustment to a patient's metabolic needs. The blood pH is sensed by an iridium oxide electrode in the right atrium. During exercise, the venous pH decreases and the paced ventricular rate increases. If acidosis persists, the paced rate gradually returns to baseline and reaches it after about 70 minutes. A pH-triggered pacemaker has been implanted in a 72-year-old male. The pacemaker remained responsive one year after implant, increasing rate during exercise, cold pressor stress, ischemia of the arms and emotional stress.
mesh_terms: D000368:Aged; D000818:Animals; D001132:Arm / Q000098:blood supply; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D003080:Cold Temperature; D004567:Electrodes, Implanted; D005069:Evaluation Studies as Topic; D005080:Exercise Test; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007495:Iridium; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D008991:Monitoring, Physiologic; D010138:Pacemaker, Artificial; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology; D014680:Veins
chemical_list: D007495:Iridium