title: Salmonella choleraesuis proteins and their relation to proteins from bacteria of heterologous sero-groups.
abstract: A diversity of proteins was identified in the material isolated from S. choleraesuis with the help of sera prepared in rabbits with this material. The sera displayed, in agar-gel diffusions, numerous superimposed precipitation lines against proteins from: Salmonellae, Shigellae and E. coli. In contrast to proteins from S. paratyphi C, sharing identical identical 'O' 'factors, the serological activity of the S. choleraesuis proteins was impaired by heating. The immunochemical analysis of the sera before and after exhaustive absorptions with heterologous proteins exhibited a stronger relation of S. choleraesuis with S. thyphimiurium and S. Newport than with S. paratyphi C. The antibodies induced against free proteins with S. paratyphi C specificity, present in the mosaic of proteins isolated from S. choleraesuis, were removed by the respective absorption without substantial modifications of the homologous precipitation. In contrast, the absorption of the serum with proteins from either S. newport or S. typhimurium removed almost all the homologous induced antibodies. The strong relations found among species belonging to different serogroups underline the non-conformity of the empirical established serofactors.
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D015478:Antigens, Heterophile / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D006358:Hot Temperature; D005779:Immunodiffusion; D011817:Rabbits; D012475:Salmonella / Q000276:immunology*; D012482:Salmonella paratyphi A / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D012760:Shigella / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D015478:Antigens, Heterophile; D001426:Bacterial Proteins