Synthesis of 4-(n-hydroxy-n-methylamino)quinoline 1-oxide and its carcinogenic activity on mice.
4-(N-Hydroxy-N-methylamino)quinoline 1-oxide (N-Me-4-HAQO), the structure of which consists of a quinoline 1-oxide moiety involved in carcinongenic 4-nitroquinoline 1-oxide and an N-hydroxy-N-methylamino group involved in N-hydroxy-N-monomethylaminoazobenzene, was sythesized and proved to be potently carcinogenic in mice by its subcutaneous injection.
D015108:4-Hydroxyaminoquinoline-1-oxide / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000634:Aminoquinolines / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000818:Animals; D002273:Carcinogens / Q000138:chemical synthesis*; D005354:Fibrosarcoma / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000473:pathology
D000634:Aminoquinolines; D002273:Carcinogens; D015108:4-Hydroxyaminoquinoline-1-oxide; C019422:4-(N-hydroxy-N-methylamino)quinoline 1-oxide