[Induction of macrophage activation with bacterial products for potentiation of resistance to some chronic infections].
Adult mice of the consanguine A2G strain received two intraperitoneal inoculations of 0.5 mg Listeria monocytogenes phospholipid extract at 30 days interval. In the treated animals and the controls, the capacity to develop a humoral immune response was tested 24 hours after the second inoculation, following antigenic stimulus with sheep red blood cells; phagocytizing in vitro of labelled germs by peritoneal macrophages and the response of lymphocytes to mitogenic and allogenic stimuli were likewise tested. The bacterial phospholipid extract activated the phagocytic function of the macrophages and the reactivity of the allogenically stimulated lymphocytes.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001424:Bacterial Infections / Q000276:immunology* / Q000628:therapy; D001688:Biological Products / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008089:Listeria monocytogenes; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D010743:Phospholipids / Q000627:therapeutic use*
D001688:Biological Products; D010743:Phospholipids
Inducerea "activării" macrofagelor cu produse bacteriene pentru potenţarea rezistenţei faţă de unele infecţii cronice.