title: [Study of the formation and the normal and pathological evolution of the eye neural primordium (author's transl)].
abstract: The analysis of duplicate embryos, cyclops and colobomic fissure defects show that: 1. - optic vesicle and colobomic fissure are inducted by the prechordal plate. The combined inductive influence of prechordal plate and notochord carry eye absence out; 2. - initial failure of the colobomic fissure is always associated with retina folds and produce lens, vitreous and optic nerve anomalies; 3. - colobomic fissure is one indispensable anatomic structure to the optic fiber migration from the retina to the optic pedicle. Retina cutting in 4 days old chick embryos determine the disappearing of the pedicle cells. Contact between the optic fiber and the pedicle cells determine the glial cells differentiation. The colobomic fissure is a very important period of the eye evolution and the eye organisation.
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities; D002642:Chick Embryo; D002699:Chlorambucil / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D004372:Ducks; D004475:Ectoderm; D005123:Eye / Q000196:embryology* / Q000473:pathology; D005124:Eye Abnormalities; D051379:Mice; D009900:Optic Nerve / Q000166:cytology / Q000196:embryology; D011817:Rabbits; D013552:Swine
chemical_list: D002699:Chlorambucil; D003520:Cyclophosphamide
vernacular_title: Etude de la formation et de l'évolution normale et pathologique de l'ébauche neurectodermique de l'oeil.