Cryocrystalglobulinemia in hairy cell leukemia.
A patient with hairy cell leukemia (leukemic reticuloendotheliosis) was noted to have a spurious leukocytosis caused by a spontaneously crystallizing cryoglobulin. The cryoprotein was identified as IgG lambda. An intracytoplasmic immunoglobulin demonstrable within the hairy cell was also IgG lambda. The cryoglobulin spontaneously disappeared over a four day period. A reliable automated count on the Coulter Model S could be obtained by prewarming the blood specimen to 37 C.
D000368:Aged; D003450:Cryoglobulins; D003951:Diagnostic Errors; D006801:Humans; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000150:complications* / Q000276:immunology; D007964:Leukocytosis / Q000175:diagnosis; D008297:Male; D010265:Paraproteinemias / Q000150:complications*
D003450:Cryoglobulins; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains