Macrodosage of phenytoin.
Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic toxicity.
D004351:Drug Resistance; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use
D010672:Phenytoin