Modification of the 5-hydroxytryptophan-induced head-twitch response by exogenous endocrine agents.
Estrogens both alone and in combination with progestagens, gonadotrophins, gonadotrophin-releasing factor, corticosteroids, and corticotrophin antagonise the head-twitch response produced by 5-hydroxytryptophan in mice. In contrast, a potentiation was seen following thyroid hormones, thyrotrophin, and thyrotrophin-releasing hormone. Pre-treatment with androgens had no significant effect. Possible mechanisms for these interactions are discussed.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000728:Androgens / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004357:Drug Synergism; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011372:Progestins / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D000728:Androgens; D004967:Estrogens; D006728:Hormones; D011372:Progestins; D013963:Thyroid Hormones; D012701:Serotonin