Reduction of respiratory tract binding of benzo[a]pyrene in mice by immunization.
Male inbred A/J mice immunized by combined ip and intranasal administration of a bovine serum albumin conjugate of 5-fluoro-12-methylbenzanthryl-7-acetic acid developed tracheal antibodies capable of binding the carcinogen benzo[a]pyrene (BP). Immunized mice administered 92 ng of [3H]BP intranasally exhibited a one-third reduction in BP content in respiratory tract tissues (nose and trachea) when compared with control mice 20 hours after BP administration.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage*; D001551:Benz(a)Anthracenes / Q000276:immunology*; D001580:Benzopyrenes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009297:Nasal Mucosa / Q000378:metabolism*; D009666:Nose / Q000276:immunology; D012142:Respiratory Tract Neoplasms / Q000517:prevention & control; D012710:Serum Albumin, Bovine / Q000008:administration & dosage; D014132:Trachea / Q000276:immunology / Q000378:metabolism*
C016461:5-fluoro-12-methylbenzanthryl-7-acetic acid; D000941:Antigens; D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D012710:Serum Albumin, Bovine; D015127:9,10-Dimethyl-1,2-benzanthracene