Experimental animal models of adriamycin cardiotoxicity.
Since patients exhibit both acute and chronic cardiac toxic effects from Adriamycin, the salient characteristics of the reported animal models for both acute and chronic cardiotoxicity are reviewed. This review reveals that while the pathology of these models is often well-characterized, the physiologic, biochemical, and nutritional variables are, in general, poorly defined.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced*; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D000882:Haplorhini; D006321:Heart / Q000187:drug effects; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012643:Selenium / Q000494:pharmacology; D013045:Species Specificity; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D004317:Doxorubicin; D012643:Selenium