Reversible adrenocorticol insufficiency in fulminant meningococcemia.
A 13-year-old girl who had been well previously was admitted with fulminant meningococcemic purpura. Her plasma cortisol level was only 3 micrograms/dL and failed to rise after cosyntropin administration. Maintenance doses of corticosteroid were administered. As her infection cleared her adrenal glands were restimulated and shown to have near normal response. Replacement doses of corticosteroids should be given to patients with fulminant meningococcemia until adrenal cortical insufficiency can be excluded because of the high incidence of adrenal failure in these patients and the possibility that excessive adrenal stimulation might contribute to adrenal abnormality.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000309:Adrenal Insufficiency / Q000188:drug therapy* / Q000209:etiology*; D003366:Cosyntropin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008585:Meningitis, Meningococcal / Q000150:complications* / Q000188:drug therapy*; D009345:Neisseria meningitidis; D012075:Remission, Spontaneous
D000305:Adrenal Cortex Hormones; D003366:Cosyntropin; D006854:Hydrocortisone