Metabolism of thromboxane B2 in the monkey.
[3H8]Thromboxane B2 was biosynthesized and infused into an unanesthetized monkey. Several urinary metabolites were isolated and their structures elucidated using gas chromatography-mass spectrometry. In addition to the major urinary metabolite, dinor-thromboxane B2, a series of metabolites resulting from dehydrogenetion of the alcohol group at C-11 were identified: 11-dehydro-thromboxane B2, 11-dehydro-15-keto-13,14-dihydro-2,3-dinor-thromboxane B2, and 11-dehydro-15-keto-13,14-dihydro-19-carboxyl-2,3,4,5-tetranor-thromboxane B2. 6-(1,3-dihydroxypropyl)-7-hydroxy-10-oxo-3-pentadecaenoic acid was also identified. Three mono-O-ethylated metabolites were formed from thromboxane B2, which in this study was infused in an ethanolic solution. A small quantity of thromboxane B2 was excreted unchanged into the urine.
D000818:Animals; D002849:Chromatography, Gas; D000882:Haplorhini; D008297:Male; D013058:Mass Spectrometry; D012669:Seminal Vesicles; D012756:Sheep; D013929:Thromboxane B2 / Q000378:metabolism* / Q000652:urine; D013931:Thromboxanes / Q000378:metabolism*
D013931:Thromboxanes; D013929:Thromboxane B2