title: Is dementia primarily a subcortical disease? Appraisal of recent biochemical observations.
abstract: Recent studies have shown some morphological, structural, metabolic, and biochemical alterations in cortical and subcortical areas of brain of patients with Dementia. In this work we have studied Choline Acetyltransferase activity in cortical and subcortical areas and we present some data that shown a involvement of subcortical structures in Demented brain.
mesh_terms: D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000201:enzymology; D001370:Axonal Transport; D001921:Brain / Q000201:enzymology / Q000473:pathology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology; D003704:Dementia / Q000473:pathology*; D006527:Hepatolenticular Degeneration / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology; D009454:Neurofibrils / Q000648:ultrastructure; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000473:pathology; D011604:Psychoses, Alcoholic / Q000473:pathology
chemical_list: D002795:Choline O-Acetyltransferase