Liver microsomal oxidations in baboon (Papio papio).
1. The activity of baboon (Papio papio) hepatic microsomes was evaluated using several model substrates. 2. As with other species studied in this laboratory, baboon microsomal enzyme activities were in the decreasing order: aldrin epoxidation greater than p-nitroanisole O-demethylation greater dihydroisodrin hydroxylation greater than benzo(a)pyrene oxidations. 3. Substrate, time, protein and cofactor requirements were examined. 4. Activities of stored frozen tissue and microsomal pellets remained similar up to seven days. 5. In the six animals studied (three male, three female), no differences in hepatic microsomal activity due to sex were apparent.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D000882:Haplorhini; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D010215:Papio; D011506:Proteins / Q000378:metabolism; D013997:Time Factors
D011506:Proteins; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases