Mezlocillin in the treatment of gonorrhoea.
A single, intramuscular dose of 2 g of mezlocillin was used for the treatment of 158 patients with gonorrhoea. In only three out of 144 patients with urogential gonorrhoea who were re-examined did the treatment fail. Of 12 patients with pharyngeal gonorrhoea who were examined after treatment 10 were treated successfully with the same dose. The sensitivities of the gonococci to mezlocillin and penicillin G correlated well, although mezlocillin seemed to be active at lower concentrations on both highly sensitive and less sensitive isolates.
D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010400:Penicillin G / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology / Q000627:therapeutic use*; D010608:Pharyngeal Diseases / Q000188:drug therapy
D010406:Penicillins; D010400:Penicillin G