title: Glycosaminoglycan accumulation with partial deficiency of beta-glucuronidase in the C3H strain of mice.
abstract: Young (60--80 days) mice of the low beta-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, "normal" Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of beta-glucuronidase, beta-galactosidase, and N-acetyl-beta-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D005966:Glucuronidase / Q000172:deficiency* / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D013154:Spleen / Q000201:enzymology; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D006025:Glycosaminoglycans; D006596:Hexosaminidases; D001616:beta-Galactosidase; D005966:Glucuronidase