Alcoholic ketoacidosis in pregnancy.
The presence of severe ketoacidosis in the absence of hyperglycemia and glucosuria is reported in a young pregnant chronic alcohol abuser. The clinical presentation included an arterial pH of 7.15, a base deficit of 23 mEq/liter, a bicarbonate of less than 10 m Eq/liter, larger serum and urinary ketone levels, and hyperpnea with Kussmual-type respiration. Corrective therapy consisted of rapid fluid, electrolyte, bicarbonate, and glucose replacement with insulin supplementation. The ability of the fetus to tolerate the maternal metabolic derangements of "alcoholic ketoacidosis" as well as the stress of uterine contractions is discussed and contrasted with diabetic ketoacidosis.
D000138:Acidosis / Q000378:metabolism; D000328:Adult; D000437:Alcoholism / Q000378:metabolism; D016883:Diabetic Ketoacidosis / Q000401:mortality; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007662:Ketosis / Q000378:metabolism / Q000628:therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000628:therapy