title: Excision of DNA damage arising from chemicals of different carcinogenic potencies.
abstract: Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, the excisabilities of the adducts formed by either bromo-compound are similar, so differences in carcinogenic potency of the compounds cannot be attributed to differences in the excisability of their DNA-adducts.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001551:Benz(a)Anthracenes / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity*; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D004260:DNA Repair / Q000187:drug effects*; D004622:Embryo, Mammalian; D007739:L Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice
chemical_list: D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D004247:DNA