title: Attempts to produce megasyndrome in mice using stocks of Trypanosoma cruzi associated with megaoesophagus in man.
abstract: Two stocks of Trypanosoma cruzi isolated from patients with advanced megaoesophagus produced megastomach in chronically infected mice. The mice showed evidence of stomach dilatation and a delay in intestinal transit time. These findings are discussed in the light of the hypothesis that regional variations in T. cruzi determines mega formation in man.
mesh_terms: D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000150:complications* / Q000000981:diagnostic imaging; D004931:Esophageal Achalasia / Q000469:parasitology*; D005260:Female; D013271:Gastric Dilatation / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D051379:Mice; D011859:Radiography; D013270:Stomach / Q000000981:diagnostic imaging; D013577:Syndrome; D014349:Trypanosoma cruzi / Q000302:isolation & purification / Q000472:pathogenicity*