[Inhibitory action of estradiol on testosterone production in rat embryo].
Embryos from Rats given an injection of 0,5-1 mg of oestradiol benzoate on days 17--19 of pregnancy show a 3--4-fold reduction in their testicular testosterone content with respect to the control embryos, 24--48 hrs later. OEstradiol most likely acts by inhibiting LH secretion, which in turn results in a lowered testosterone production.
D000818:Animals; D004622:Embryo, Mammalian; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D011247:Pregnancy; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis*
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone
Action inhibitrice de l'oestradiol sur la production de testostérone chez l'embryon de rat.