Regulation of the kidney xanthine dehydrogenase by glutaminase.
The steady-state concentrations of glutamine, glutamate and ammonia in the kidney cells might regulate the rate of renal xanthine dehydrogenase activity. Both glutamate and glutamine were found to be effective inhibitors of the renal xanthine dehydrogenase activity in vivo. The inhibition by glutamate depends essentially on the glutaminase inhibition.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D005971:Glutamates / Q000494:pharmacology; D005972:Glutaminase / Q000378:metabolism*; D005973:Glutamine / Q000494:pharmacology; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D051381:Rats; D014968:Xanthine Dehydrogenase / Q000378:metabolism*
D005971:Glutamates; D005973:Glutamine; D014968:Xanthine Dehydrogenase; D007658:Ketone Oxidoreductases; D005972:Glutaminase