title: Preliminary results in the immunization of Irus monkeys against dental caries.
abstract: Twelve Irus monkeys were divided into four groups which were immunized with placebo, two cell wall preparations and one vaccine containing a glucosyltransferase preparation of S. mutans. After 310 days of challenge by a cariogenic diet, the caries score in all the immunized animals was below that of the controls. Furthermore, the protected animals were characterized by a high specific serum titer against the antigens used for immunization and the extension of plaque seemed to be smaller when compared with the controls.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002473:Cell Wall / Q000276:immunology; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology; D004037:Diet, Cariogenic; D004195:Disease Models, Animal; D005260:Female; D005964:Glucosyltransferases / Q000276:immunology; D000882:Haplorhini; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D012463:Saliva / Q000276:immunology; D013295:Streptococcus mutans / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D005964:Glucosyltransferases