title: Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon.
abstract: 13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.
mesh_terms: D015110:4-Hydroxycoumarins / Q000097:blood*; D000818:Animals; D002415:Cats; D002417:Cattle; D004285:Dogs; D006041:Goats / Q000097:blood; D006168:Guinea Pigs; D000882:Haplorhini; D006736:Horses / Q000097:blood; D006801:Humans; D051379:Mice; D010644:Phenprocoumon / Q000097:blood*; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*; D013045:Species Specificity; D013237:Stereoisomerism; D013552:Swine / Q000097:blood
chemical_list: D015110:4-Hydroxycoumarins; D012709:Serum Albumin; D010644:Phenprocoumon