[Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine].
We have studied the molecular structure of platelet-activating factor" (P.A.F.), a mediator of inflammation obtained from blood leukocytes, macrophages, and platelets themselves. We have semi-synthetized a substance that possesses all the known physicochemical and biological characteristics of P.A.F. from hog leukocytes. This was performed by successive methylation, hydrogenation, and acetylation of lysophosphatidylethanolamine plasmalogen. We therefore propose the following structure for P.A.F.: 1-0-alkyl-2-acetyl-glyceryl-3-phosphorylcholine. This molecular structure is not yet described among the numerous substances capable of inducing platelet aggregation and release.
D000107:Acetylation; D000818:Animals; D008244:Lysophosphatidylcholines / Q000138:chemical synthesis / Q000494:pharmacology; D008722:Methods; D008745:Methylation; D010955:Plasmalogens; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D008244:Lysophosphatidylcholines; D010955:Plasmalogens; D010972:Platelet Activating Factor
Semi-synthèse et structure proposée du facteur activant les plaquettes (P.A.F.): PAF-acether, un alkyl ether analogue de la lysophosphatidylcholine.