title: Long-term antihypertensive therapy with prazosin plus a diuretic.
abstract: Prazosin was administered to 21 diuretic-treated mild hypertensives for intervals of 1 month to 1 year. Three patients dropped out of the study, one from side-effects, one from noncompliance and the third for relocation. At 1, 6, and 12 months of follow-up therapy, blood pressures were reduced by 9--12%. Pulse rate was essentially unchanged. Thus prazosin appears to lower blood pressure for periods up to 1 year with little evidence of tolerance and with no change in heart rate.
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002908:Chronic Disease; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000009:adverse effects / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D004232:Diuretics; D011799:Quinazolines; D011224:Prazosin