Haematological changes in hyperimmunized rabbits treated with hydrazinophthalazines for long time periods.
Haematological investigations of peripheral blood and bone marrow were performed in rabbits receiving hydrazinophthalazines (hydralazine or binazin) with or without simultaneous hyperimmunization by means of repeated injections of bovine albumin. It was found that long-term administration of hydralazine caused appearance of LE factor in the serum and LE cells in blood. Less evident changes were caused by Binazin administration. Hyperimmunization caused weaknening of the effects of hydralazinophthalazines. Haematological investigations demonstrated hypochromic anaemia.
D000818:Animals; D001772:Blood Cell Count; D004906:Erythrocyte Count; D004909:Erythrocyte Indices / Q000187:drug effects; D004911:Erythrocyte Volume / Q000187:drug effects; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006830:Hydralazine / Q000494:pharmacology*; D006834:Hydrazines / Q000494:pharmacology*; D007117:Immunization, Secondary; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced; D008297:Male; D009504:Neutrophils; D010976:Platelet Count; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D014032:Todralazine / Q000494:pharmacology*
D006454:Hemoglobins; D006834:Hydrazines; D006830:Hydralazine; D012710:Serum Albumin, Bovine; D014032:Todralazine