[The induction and disappearance of complement-fixing antibodies in the blood serum of experimental animals under the antigenic action of Trichomonas vaginalis, T. hominis and T. tenax].
For studying the dynamics of induction and disappearing of complement-fixing antibodies (CFA) specific to Trichomonas vaginalis, T. hominis and T. tenax we have immunized rabbits intravenously with live individuals of the protozoa as well as intravenously, intramuscularly and subcutaneously with individuals killed at 56 degrees C. Each method of immunization was carried out by 5 inoculations with intervals of 10 days. For carrying out quantitative complement fixation we have taken blood from the ear vein of all immunized rabbits immediately before the immunization and also after it, each 10th day during one year. The dynamics of rising and lowering of titres depended on the species of trichomonads and on the method of immunization. The antigens of T. vaginalis and T. hominis induced CFA in much higher titres as antigens of T. tenax. Titres of CFA specific for all three species of above-mentioned trichomonads rose most rapidly and to the highest level when the immunization of rabbits was carried out intravenously with live individuals of protozoa. Normalization of the titres of CFA has taken place during one year at least.
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000097:blood; D000918:Antibody Specificity / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology*; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000032:analysis*; D007114:Immunization; D011817:Rabbits; D013997:Time Factors; D014244:Trichomonas / Q000276:immunology*; D014246:Trichomonas vaginalis / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D003165:Complement System Proteins
Vozniknovenie i ischeznovenie komplementsviazyvaiushchikh antitel v syvorotke krovi podopytnykh zhivotnykh pod deĭstviem antigenov Trichomonas vaginalis, T. hominis i T. tenax.