Renal phosphate clearance in fetal lambs.
The purpose of this study was to investigate the possible role of diminished phosphate clearance by the fetal kidney in production of relative fetal hyperphosphatemia. Stimuli known to affect renal phosphate clearance in adults were investigated in young fetal lambs. Our studies confirm that the fetal lamb kidney responds to exogenous and endogenous parathyroid hormone (PTH) with inhibition of tubular phosphate reabsorption. Renal tubular phosphate reabsorption in the fetus is in part related to sodium reabsorption. These studies indicate that so-called "immaturity" of renal phosphate clearance in utero is not a significant factor in production of fetal hyperphosphatemia.
D000818:Animals; D002118:Calcium / Q000008:administration & dosage; D004492:Edetic Acid / Q000008:administration & dosage; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006438:Hemodilution; D007684:Kidney Tubules / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000097:blood; D010710:Phosphates / Q000097:blood*; D011247:Pregnancy; D012756:Sheep
D010281:Parathyroid Hormone; D010710:Phosphates; D004492:Edetic Acid; D002118:Calcium