Stimulation of human B lymphocytes by Listeria cell wall fraction.
Cell wall fraction of Listeria monocytogenes (LCWF), a B cell mitogen for mouse spleen cells, is also mitogenic for human adult and cord peripheral blood lymphocytes. Purified B-cell suspensions responded to LCWF in vitro proliferation, to a similar extent as the unfractionated suspensions. Furthermore, LCWF-induced B cell differentiation into IgM-containing cells and their percentage correlated significantly with the extent of lymphocyte proliferation.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D002473:Cell Wall / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008089:Listeria monocytogenes / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D010510:Periodontal Diseases / Q000276:immunology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013347:Subcellular Fractions / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007075:Immunoglobulin M; D011043:Pokeweed Mitogens