N-Benzoyl derivatives of amino acids and amino acid analogs as growth inhibitors in microbial antitumor screen.
Twenty-seven N-benzoyl derivatives of amino acids and amino acid analogs were prepared and tested for growth-inhibitory activity in a microbial antitumor screen. Of these, 19 showed some inhibitory capacity, from a modest 13% to a potent 96% at 1 mg/ml. The activities of the "modest" inhibitors were comparable to those of most inhibitory chloracetyl and trifluoroacetyl derivatives reported earlier. The intermediate inhibitors were as active as N-chloroacetyl-beta-hydroxy-D-norleucine isomer B, the most active acyl derivative noted previously. The most active compounds in this study were N-benzoyl-p-chloro-DL-phenylalanine and N-benzoyl-m-fluoro-DL-phenylalanine, which inhibited the test organism almost completely under the assay conditions.
D000596:Amino Acids / Q000494:pharmacology*; D000970:Antineoplastic Agents; D004353:Drug Evaluation, Preclinical; D007780:Lacticaseibacillus casei / Q000187:drug effects* / Q000254:growth & development
D000596:Amino Acids; D000970:Antineoplastic Agents