Physico-chemical interpretation with cells electrophoresis of some antigen -- antibodies reactions in immuno-hematology.
The authors report the action of different antibodies of complete or incomplete type on the electrophoretic mobility of red-blood cells. They try to explain the results in terms of physicochemical stability. They make a distinction between three main possible classes concerning the mechanisms of action: a. direct diminution of the Zeta potential due to the antibody which in this case, is agglutinant. b. diminution of electrocinetic potential by "etching" of ionized groups responsible of the charge. To this mechanism, we could link the increase of the ionic force. c. Artificial increase of the dielectric constant by macromolecules.
D000017:ABO Blood-Group System; D000818:Animals; D000937:Antigen-Antibody Reactions; D004586:Electrophoresis; D004912:Erythrocytes / Q000276:immunology* / Q000648:ultrastructure; D006168:Guinea Pigs; D006801:Humans; D037102:Lectins; D010641:Phenotype; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D037102:Lectins; D012204:Rh-Hr Blood-Group System