title: [Morphological differentiation of neuroblastoma by 1 methyl cyclohexane carboxylic acid (CCA) and some C1 derivatives].
abstract: We describe the induction of neuroblastoma morphological differentiation by 1 methyl cyclohexane carboxylic acid (CCA) and by some C1 derivatives of CCA. This induction proceeds in a medium which allows, in the absence of inducer, a normal growth of neuroblastoma cells and contains 7.5% fetal Calf serum. In order to establish a clear-dose response relationship and to compare the relative potencies of different drugs, the morphological changes were assessed by examining "long neurite-bearing cells".
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D051379:Mice; D009447:Neuroblastoma / Q000503:physiopathology*; D013329:Structure-Activity Relationship
chemical_list: D003509:Cyclohexanecarboxylic Acids
vernacular_title: Différenciation morphologique du neuroblastome par l'acide 1 méthyl cyclohexane carboxylique (CCA) et certains dérivés en C1.