title: Lack of correlation between MMS-toxicity in larvae and in adults of mutagen-sensitive mutants of Drosophila melanogaster.
abstract: Adult males of 20 different stocks of Drosophila melanogaster, including 16 with various X-linked mutagen-sensitive mutations, were tested for sensitivity to the lethal action of methyl methane sulfonate (MMS) in a continuous feeding experiment. It was impossible to establish a correlation between MMS-toxicity in adults and MMS-toxicity in larvae. In addition, experiments to examine the fertility of MMS-treated flies of four mutagen-sensitive strains and one wild-type strain were performed. These experiments demonstrated that the spermatogonia of mei-9L1 and mei-41D5 in larvae and in adults are more sensitive to MMS than the spermatogonia of the wild-type strain or the other two mutagen-sensitive strains.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004032:Diet; D004331:Drosophila melanogaster / Q000235:genetics*; D005298:Fertility / Q000187:drug effects; D008297:Male; D008741:Methyl Methanesulfonate / Q000008:administration & dosage / Q000633:toxicity*; D012737:Sex Factors
chemical_list: D008741:Methyl Methanesulfonate