[Effect of ASS on platelet function in experimental DIC].
In thrombin-induced DIC, acetylsalicylic acid (ASA) prevents the strong initial fall in platelet count and the obturation of the microvasculature of the lung with platelet aggregates. During the DIC reaction increasing inhibition of aggregability of circulating platelets against collagen and ADP is observed. Furthermore, ASA prevents the increase in the plasma haemoglobin level caused by DIC.
D000818:Animals; D000933:Antifibrinolytic Agents; D001241:Aspirin / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D011292:Premedication; D051381:Rats; D013917:Thrombin
D000933:Antifibrinolytic Agents; D013917:Thrombin; D001241:Aspirin
Einfluss von ASS auf die Plättchenfunktion bei der experimentellen DIC.