Multiple systemic and periocular malformations associated with the fetal hydantoin syndrome.
Anticonvulsants remain necessary during pregnancy and the removal of such drugs is not recommended. However, on the available evidence, the physician may expect an increased risk of malformation including eye abnormalities as has been outlined. The abnormalities include growth deficiencies and delayed motor/mental development together with dysmorphic features, the most common of which seems to be cleft lip/cleft palate. Additionally, many of these children suffer from eye abnormalities including hypertelorism, ptosis, strabismus, epicanthal folds, and in this case abnormalities of the lacrimal apparatus.
D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001763:Blepharoptosis / Q000139:chemically induced; D002675:Child, Preschool; D002971:Cleft Lip / Q000139:chemically induced; D002972:Cleft Palate / Q000139:chemically induced; D005124:Eye Abnormalities; D005143:Eyelids / Q000002:abnormalities; D005145:Face / Q000002:abnormalities; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects*; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities; D007765:Lacrimal Apparatus / Q000002:abnormalities; D008297:Male; D011247:Pregnancy; D013285:Strabismus / Q000139:chemically induced; D013577:Syndrome
D000927:Anticonvulsants; D006827:Hydantoins