title: Effect of cyproterone acetate (CA) on growth and endocrine function in precocious puberty.
abstract: 16 girls with precocious puberty have been studied. Following low dosage cyproterone acetate (CA) therapy (mean daily dosage 65 mg/m2BSA) a beneficial effect on growth and skeletal maturation was observed. During high dosage therapy (150 mg/m2 per day) endocrinological studies were performed in 10 of these patients. There was no significant difference in HGH levels (insulin- and arginine-test), T3 and TSH values (TRH-test) between patients and controls, T4 concentration was significantly increased. Basal prolactin levels and prolactin response to TRH was definitely elevated. Oral glucose load and arginine infusion resulted in a significantly enhanced insulin release. There was a significant reduction in basal LH levels and an increase in FSH response to LH-RH. Basal and diurnal plasma cortisol values were markedly reduced and the cortisol release due to corticotrophin injection, lysinevasopressin (LVP) injection and insulin-hypoglycemia as well. A definite increase in basal ACTH levels was observed, during LVP- and insulin-hypoglycemia test ACTH concentrations were within or significantly above normal range. In our patients a primary adrenocortical insufficiency due to CA treatment was evident.
mesh_terms: D001120:Arginine; D001827:Body Height / Q000187:drug effects; D003534:Cyproterone / Q000008:administration & dosage / Q000627:therapeutic use*; D005947:Glucose; D006128:Growth / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin; D008236:Lypressin; D008297:Male; D010908:Pituitary Hormones, Anterior / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood
chemical_list: D007328:Insulin; D010908:Pituitary Hormones, Anterior; D008236:Lypressin; D013973:Thyrotropin-Releasing Hormone; D001120:Arginine; D003534:Cyproterone; D005947:Glucose; D013974:Thyroxine; D006854:Hydrocortisone