[Effect of lymphokines produced in a grafted system on production of prostaglandins by macrophages].
Mice peritoneal macrophages cultured in vitro release a prostaglandin-like activity as evaluated by a bio-assay using Rat stomach fundus. The prostaglandin release is greatly increased when macrophages are incubated with the supernatant of mixed lymphocyte cultures between recipient and donor of a skin allograft. This phenomenon was found in all strains of Mice tested except C3H/HeJ Mice, a strain already known for its defective responsiveness to bacterial lipopolysaccharide (LPS).
D000818:Animals; D001681:Biological Assay; D008222:Lymphokines / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011453:Prostaglandins / Q000096:biosynthesis* / Q000494:pharmacology; D012867:Skin / Q000098:blood supply; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D008222:Lymphokines; D011453:Prostaglandins
Action des lymphokines produites en système de greffe sur la production de prostaglandines par les macrophages.