Allelic exclusion in the B lineage cells of the rabbit.
Allelic exclusion of the K polypeptide chain allotypes b4 and b5 of the rabbit exists for the immunoglobulins of almost all plasma cells and of most mature small B lymphocytes. However, both these alleles are expressed simultaneously in rare plasma cells and in an usually large fraction of the lymphoid cells of the bone marrow. Our experiments support the idea that such bone marrow B lineage cells do not always show allelic exclusion.
D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D005455:Fluorescent Antibody Technique; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007140:Immunoglobulin Fab Fragments; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008213:Lymphocyte Activation; D010641:Phenotype; D011817:Rabbits; D013154:Spleen / Q000276:immunology
D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; C496591:kappa allotype b4, rabbits