title: [Physiopathology of prostaglandin I2 synthesis in the human gastrointestinal mucosa].
abstract: 1. PGI2 is synthetized in human gastrointestinal mucosa. 2. PGI2 seems to be responsible for pathophysiological conditions. 3. Disorders caused by an enhanced or diminished PGI2-synthesis could be treated in the future by inhibition of prostacyclin synthetase or exogenous synthetic PGI2 respectively. 4. In order to remove the problems with the unstable PGI2, synthetic analogs could be used for the treatment.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D003093:Colitis, Ulcerative / Q000201:enzymology*; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology*; D006168:Guinea Pigs; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats
chemical_list: D011453:Prostaglandins; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases
vernacular_title: Pathophysiologische Aspekte der Prostaglandin I2-Synthese der menschlichen Magen-Darmschleimhaut.