[Macro-creatine kinase; circulating immunoglobulin enzyme complexes as cause of elevated CK-activities (author's transl)].
We report a case of a woman (58 years old) with persistent and elevated CK activities and without corresponding clinical signs. For seven months CK-B activity was determined above normal by an inhibition test. By exclusion chromatography, ion-exchange chromatography, electrophoresis of CK isoenzymes and immunological methods we were able to explain this phenomenon as Macro CK consisting of immunoglobulin G bound CK-BB.
D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003402:Creatine Kinase / Q000097:blood*; D004587:Electrophoresis, Agar Gel; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D007527:Isoenzymes; D046911:Macromolecular Substances; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology; D011485:Protein Binding; D013997:Time Factors
D007074:Immunoglobulin G; D007527:Isoenzymes; D046911:Macromolecular Substances; D003402:Creatine Kinase
Makro-Kreatinkinase; Zirkulierende Immunglobulin-Enzym-Komplexe als Ursache erhöhter CK-Aktivitäten.