[Age dependent structural changes in non collagen proteins and their consequences in protein turnover degradative rate (author's transl)].
During the aging process the occurence of proteins with physico-chemical properties different from their juvenile counterparts are observed in many organisms. The probable molecular mechanisms of such variations are reviewed. Although no direct evidence could be found in the literature for an altered breakdown rate of such a single "old" protein, the possible influence of this kind of modifications in protein molecules on their over all degradative rate is discussed.
D000375:Aging; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004331:Drosophila melanogaster; D006801:Humans; D008099:Liver / Q000166:cytology; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism; D011506:Proteins / Q000032:analysis / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013769:Tetrahymena pyriformis
D011506:Proteins; D010447:Peptide Hydrolases
Alternsbedingte Strukturveränderungen an Nichtkollagenproteinen und deren mögliche Bedeutung für den Proteinabbau.