Hemostasis in schistosomiasis mansoni.
Hemostasis was studied in 18 patients with the hepato-intestinal form of Schistosomiasis mansoni and in 23 with the hepato-splenic form. Both groups are compared referring to alterations found. The relations between plasmatic coagulation factors and hepatocytic function tests are studied. In 6 patients the explorations were repeated after administration of hycanthone. In the patients with the hepato-splenic form, the presence of chronic consumptive coagulophathy was found. The coagulopathy disappeared either by treatment with heparine or by splenectomy. This observation points out the importance of splenomegaly in the development of chronic consumptive coagulopathy, and may be an important factor in indicating splenectomy in a patient with portal hypertension due to Schistosomiasis mansoni.
D000328:Adult; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006489:Hemostatic Techniques; D006801:Humans; D006826:Hycanthone / Q000494:pharmacology; D007411:Intestinal Diseases, Parasitic / Q000601:surgery; D008109:Liver Diseases, Parasitic / Q000601:surgery; D008297:Male; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000097:blood* / Q000150:complications / Q000601:surgery; D013156:Splenectomy
D006826:Hycanthone