Unusual evidence of myocardial involvement during a hypersensitivity reaction to oral penicillin.
A hypersensitivity reaction to orally administered phenoxymethyl penicillin is reported. The manifestations of the reaction included fever, arthralgia, urticaria and an irregular pulse. Serial ECG showed second-degree atrioventricular block with junctional escape beats, an atypical Wenckebach pattern and, finally, first-degree atrioventricular block with gradually decreasing PR intervals. A normal tracing was recorded on the sixth day despite the persistence of the rash and joint pains.
D000328:Adult; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010404:Penicillin V / Q000009:adverse effects*; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes
D010404:Penicillin V