[Role of vitamin A in chemical carcinogenesis in the mammary gland].
The effect of feeding rats with high doses of vitamin A on the distribution of polycyclic hydrocarbon, 7,12-dimethylbenzanthracene (DMBA) and its metabolites in different organs and blood, and also on the metabolic rate in the liver was studied following intravenous injection of the carcinogen. Hypervitaminosis A resulted in a significant decrease of the level of DMBA and its metabolites in all the organs investigated and in the blood. The rate of DMBA metabolism in the liver of the animals rose with the increase of the vitamin A dose.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage*
D014801:Vitamin A; D015127:9,10-Dimethyl-1,2-benzanthracene
Issledovanie roli vitamina A v khimicheskom kantserogeneze molochnoĭ zhelezy.