Sensitivity of TSTA and species-specific cell membrane antigens of tumor cells to glutaraldehyde treatment.
In vivo immunogenicity and in vitro species-specific membrane antigens in tumor cells treated or untreated with glutaraldehyde (GA) were studied. Two different syngeneic Syrian hamster transplantable tumor cell lines (spontaneous liver cancer and SV40-induced sarcoma) not only lost immunogenicity after GA treatment but were responsible for enhancement of test-tumor growth in immunized animals. In vitro mixed hemadsorption test used for determination of species-specific membrane antigens in Syrian hamster, green monkey and interspecies hybrid cells revealed drastic alteration of antigens on the membrane of cells treated with GA.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D006224:Cricetinae; D005976:Glutaral / Q000494:pharmacology*; D006649:Histocompatibility Antigens / Q000008:administration & dosage; D007109:Immunity; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D013045:Species Specificity; D014185:Transplantation, Isogeneic
D000447:Aldehydes; D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens; D005976:Glutaral