title: Transfer of plasmid-mediated antibiotic resistance in strains of Pseudomonas aeruginosa isolated in Auckland.
abstract: Of 422 clinical strains of Pseudomonas aeruginosa, 23 (5.5%) were resistant to gentamicin; 19 were also resistant to tobramycin and sisomycin, and one was resistant to tobramycin, sisomycin and amikacin. Of the gentamicin-resistant strains, 20 were also resistant to kanamycin. Sixteen strains with a high level of resistance to gentamicin (MIC greater than 160 microgram/ml) transferred all their resistance determinants to recipient strains of P. aeruginosa and four transferred some resistance determinants to P. aeruginosa but none transferred resistance to a recipient strain of E. coli K12. These results show that gentamicin resistance in strains of P. aeruginosa isolated in Auckland is mediated by R plasmids.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009520:New Zealand; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics*; D011815:R Factors
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins