The effect of cimetidine, a new histamine H2-receptor antagonist, on renal function.
Serum creatinine, endogenous creatinine clearance, (51Cr)EDTA plasma clearance and the concentration of beta2-microglobulin in serum and urine were determined in 19 patients before and during treatment with cimetidine for peptic ulcer disease. The mean concentrations of creatinine and beta2-microglobulin in serum increased significantly within normal limits after 2 and 6 weeks' treatment. However, creatinine clearance and (51Cr)EDTA plasma clearance were unchanged during the treatment. Thus, the observed increases in serum creatinine and beta2-microglobulin could not be explained by a diminished glomerular filtration rate. Inhibited tubular secretion of creatinine may explain the observed increase in serum creatinine during cimetidine treatment. Another hypothetical possibility is that a small increase in tubular reabsorption of both creatinine and beta2-microglobulin would account for the observed increases in creatinine and beta2-microglobulin in serum. It is concluded that, although statistically significant, the increases in serum creatinine and beta2-microglobulin are small and therefore of little relevance for the patient's treatment with cimetidine.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood / Q000652:urine; D004492:Edetic Acid / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D001613:beta 2-Microglobulin / Q000378:metabolism
D006146:Guanidines; D001613:beta 2-Microglobulin; D002927:Cimetidine; D004492:Edetic Acid; D003404:Creatinine