Species variability in plasma S-sulfonate levels during and following sulfite administration.
It has been shown that S-sulfonate compounds (R-S-SO-3) are produced by the action of sulfite on reactive disulfide bonds [4,5]. Plasma S-sulfonate production was determined as a function of sulfite ingestion and intraperitoneal injection in rats, mice and rhesus monkeys. The tendency of these species and of the rabbit [8] to produce S-sulfonates in plasma was related to the availability of sulfite and of reactive disulfide bonds and to the stability of plasma protein S-sulfonates. The rhesus monkey and the rabbit accumulated plasma S-sulfonates much more readily than did the rat, while the mouse produced little, if any, under the same test conditions. Plasma protein S-sulfonate fractions in the rat and rhesus monkey were characterized by half-lives of approximately 4 and 8 days respectively. The sensitivity and precision of the analytical method for plasma protein S-sulfonate were improved by incorporation of 35S into the outer sulfur atom of the S-sulfonate moiety (R-S-35SO-3).
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013447:Sulfites / Q000097:blood / Q000378:metabolism*; D013451:Sulfonic Acids / Q000097:blood*; D013462:Sulfur Radioisotopes; D013997:Time Factors
D001798:Blood Proteins; D013447:Sulfites; D013451:Sulfonic Acids; D013462:Sulfur Radioisotopes