title: Current concepts of abnormal stem cell proliferation in human disease.
abstract: Using acute myeloid leukemia as an example, the concept of abnormal hematopoietic stem cell production has been examined. It is concluded that the major problem does not lie in humoral regulators, either stimulators or inhibitors, of stem cell production but in intrinsic cellular defects which do not allow cells to respond to these materials. The nature of the stem cell defects has not been defined. Similar mechanisms appear to exist in other human hematopoietic disorders in which abnormal stem cell proliferation is a major feature.
mesh_terms: D000818:Animals; D001853:Bone Marrow; D001855:Bone Marrow Diseases / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D046508:Culture Techniques; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D051379:Mice
chemical_list: D003115:Colony-Stimulating Factors