[Effect of nitroglycerin on the tonus of isolated coronary arteries].
It has established on isolated ring-like strips of large coronary arteries of the dog that spasmolytic effects of nitroglycerin are related to its antagonistic action on Ca2+ and are not completely pharmacomechanic. The action of nitroglycerin is not related to beta-adrenoreceptors of the coronary arteries and apparently is not mediated through an increase in the intracellular pool of cyclic AMP.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002413:Cations, Divalent; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*
D002413:Cations, Divalent; D005996:Nitroglycerin; D002118:Calcium
Vliianie nitroglitserina na tonus izlirovannykh koronarnykh arteriĭ.