(+)-Cyanidanol-3 as inhibitor of prostaglandin synthetase. Studies on renal medulla and liver of the rat in vitro and in vivo.
(+)-Cyanidanol-3 inhibits the prostaglandin synthetase of the renal medulla and of the liver of rats in vitro and after treatment of the animals with 200 mg/kg. A half-maximal inhibition of the enzyme was obtained with 5 . 10(-5) M cyanidanol. If the microsomal inhibitor CFT1201 is first applied, the inhibitory effect in vivo of 50% is increased to 80%. It is supposed that cyanidanol is converted to metabolites which, according to our earlier studies, activate the enzyme system. An enzyme activity of the rat liver was measured which - with a turnover of 18-20% - was significantly higher than the values obtained by other authors.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D013997:Time Factors
D001095:Arachidonic Acids; D001578:Benzopyrans; D016861:Cyclooxygenase Inhibitors; D002392:Catechin