Amino acid sequence analysis of group e allotype-related peptides derived from lagomorph IgG.
A tryptic peptide (T 19) was isolated from a CNBr fragment of IgG from several representatives of present-day lagomorphs including domestic rabbit, hare, cottontail rabbit and pika. The amino acid sequence of this peptide revealed differences which can be correlated with serological polymorphism associated with group e IgG allotypes. The results confirm previous studies establishing the importance of Ala309 for the expression of e 15, particularly the i subspecificity. Arg315 correlates with the expression of the j subspecificity.
D000595:Amino Acid Sequence; D000818:Animals; D001666:Binding Sites, Antibody; D003176:Complement C3 / Q000302:isolation & purification; D003488:Cyanogen Bromide; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D007793:Lagomorpha; D010455:Peptides / Q000276:immunology* / Q000302:isolation & purification
D003176:Complement C3; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D010455:Peptides; D003488:Cyanogen Bromide