Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds.
Thyrotropin-releasing hormone (TRH), sodium valproate, AF-3-5 (1-[2-hydroxyphenyl]-4-[3-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one), RX336-M (7,8-dihydro-5',6'-dimethylcyclohex-5'-eno-1',2',8',14 codeinone), and Sgd 8473 (alpha-[4-chlorobenzylideneamino)-oxy]-isobutyric acid) each induced repetitive shaking of the body of rats after intraperitoneal injection. This action of the five diverse chemicals appears to be subserved by a common pharmacological component, because pretreatment with d-lysergic acid diethylamide (0.03--1.0 mg kg-1, s.c.) attenuated the shaking behavior in a dose-related manner, and cross tolerance was found between RX336-M and TRH, sodium valproate, and AG-3-5.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002087:Butyrates / Q000037:antagonists & inhibitors; D003061:Codeine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D004361:Drug Tolerance; D006120:Grooming; D006877:Hydroxamic Acids / Q000037:antagonists & inhibitors; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D011744:Pyrimidinones / Q000037:antagonists & inhibitors; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D013997:Time Factors; D014635:Valproic Acid / Q000037:antagonists & inhibitors
D002087:Butyrates; D006877:Hydroxamic Acids; D011744:Pyrimidinones; C012670:alpha-((4-chlorobenzylideneamino)oxy)isobutyric acid; D013973:Thyrotropin-Releasing Hormone; D014635:Valproic Acid; D008238:Lysergic Acid Diethylamide; D003061:Codeine