[In vitro malignant transformation of hamster lung cells by 2-chlorobutadiene].
Normal Hamster lung cells from an established line were treated with 1-500 microgram . ml-1 2-chlorobutadiene. Those treated with 1 microgram . ml-1 of the compound showed malignant transformations 14 weeks after treatment. The treatment with higher concentrations did not accelerate the transformation process.
D000818:Animals; D002070:Butadienes / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002737:Chloroprene / Q000494:pharmacology*; D006224:Cricetinae; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D008175:Lung Neoplasms / Q000139:chemically induced; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D014182:Transplantation, Autologous
D002070:Butadienes; D002737:Chloroprene
Transformation in vitro de cellules de poumons de jeunes hamsters par le chloro-2 butadiène (CB).