1-phenyl-3-pyrazolidone: an inhibitor of cyclo-oxygenase and lipoxygenase pathways in lung and platelets.
1-phenyl-3-pyrazolidone (phenidone) is a commercially available reagent used in the photographic industry. When tested as an inhibitor of arachidonic acid metabolsim in platelets and lungs it was found to be effective against both the cyclo-oxygenase and lipoxygenase pathways. It is suggested that this compound may be a useful pharmacological tool.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000201:enzymology*; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006736:Horses; D007202:Indicators and Reagents; D008084:Lipoxygenase / Q000097:blood; D016859:Lipoxygenase Inhibitors; D008168:Lung / Q000201:enzymology*; D010105:Oxygenases / Q000037:antagonists & inhibitors* / Q000097:blood; D011720:Pyrazoles / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D010105:Oxygenases; D008084:Lipoxygenase