title: Alcohol and hamster buccal pouch carcinogenesis.
abstract: Alcohol was shown to enhance the carcinogenic effect of DMBA applied to hamster buccal pouch. DMBA animals given alcohol developed dysplastic leukoplakic lesions and epidermoid carcinomas 2 weeks ahead of water-drinking control animals. The tumors also grew to larger size, were more invasive, and were more anaplastic histologically. Forty young adult Syrian hamsters were divided into four groups (alcohol-DMBA, DMBA control, untreated control, and alcohol control) and were killed after 10, 12, and 14 weeks of DMBA applications three times weekly. Alcohol was given as a 10 percent solution instead of drinking water.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001551:Benz(a)Anthracenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D002610:Cheek; D006224:Cricetinae; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D007642:Keratosis / Q000473:pathology; D007972:Leukoplakia, Oral / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000187:drug effects; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology
chemical_list: D001551:Benz(a)Anthracenes; D000431:Ethanol; D015127:9,10-Dimethyl-1,2-benzanthracene