Abnormal lipoprotein appearing in plasma of patients who received a ten percent soybean oil emulsion infusion.
In 42 of 43 surgical patients who received a 10% soybeam oil emulsion (Intralipid), abnormal lipoprotein was detected in their plasma 1 to 2 days after the initial Intralipid infusion. This abnormal lipoprotein was proven to appear as a result of the infusion of soybean oil emulsion regardless of the patient's original diseases, age, sex, liver function, or concomitantly administered solutions. In addition, this abnormal -ipoprotein was found to have various similarities to lipoprotein-X (LP-X) which is found in plasma from patients with obstructive jaundice or familial lecithin:cholesterol acyltransferase deficiency. Therefore, this abnormal lipoprotein was tentatively named LP-X--like substance (LP-X-LS). A comparison of the properties of LP-X and LP-X-LS was performed and the following results were obtained: (1) LP-X-LS migrated toward the cathode on Bacto-Agar gel electrophoresis similarly to LP-X; (2) the stability of LP-X and LP-X-LS against heating and freezing were almost equal under various conditions; (3) LP-X-LS could be absorbed by anti--LP-X serum; (4) LP-X-LS existed in low density fraction (d = 1.063) separated by ultracentrifugation from plasma; (5) electron microscopic study of low-density lipoprotein particles from LP-X-LS positive plasma revealed that LP-X-LS had a similar ultrastructure to LP-X. From these results it is suggested that LP-X-LS is an abnormal lipoprotein quite similar to LP-X.
D000328:Adult; D000818:Animals; D000941:Antigens; D002784:Cholesterol / Q000097:blood; D004587:Electrophoresis, Agar Gel; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005260:Female; D000882:Haplorhini; D006801:Humans; D007223:Infant; D008074:Lipoproteins / Q000032:analysis / Q000097:blood* / Q000276:immunology; D008297:Male; D008854:Microscopy, Electron; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000941:Antigens; D005217:Fat Emulsions, Intravenous; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol