The VkVI subgroup of rabbit light chains: complete amino acid sequence of a third variable region (K29-213).
The amino acid sequence of the variable region of a rabbit anti-streptococcal A-variant antibody light chain was determined. By using a combination of different cleavage methods, the sequence was established. Large peptides were sequenced in an extensively modified Beckman sequentor. Light chain K29-213 belongs to a rare subgroup (kVI). Several of these light chains of antibodies with different specificities have been totally or partially sequenced. Comparison of these light chains reveals at least four germ-line-encoded variants within this subgroup.
D000595:Amino Acid Sequence; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D000918:Antibody Specificity; D007147:Immunoglobulin Light Chains / Q000032:analysis* / Q000302:isolation & purification; D007145:Immunoglobulin kappa-Chains / Q000032:analysis* / Q000302:isolation & purification; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011817:Rabbits; D013297:Streptococcus pyogenes / Q000276:immunology
D000907:Antibodies, Bacterial; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D011135:Polysaccharides, Bacterial