[Stimulation of G-6-P independent glycogen synthase activity in the human placenta].
In immature human placentas, the activity of the I (glucose-6-phosphate-independent) form of glycogen synthase is significantly increased by insulin, glucose and by both compounds associated. In full-term placentas, the same kind of results has been found in each organ studied; due to the great variability observed in synthetase I control activities, the stimulation is significant only in the presence of insulin.
D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D005958:Glucosephosphates; D006006:Glycogen Synthase / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007743:Labor, Obstetric; D010920:Placenta / Q000187:drug effects / Q000201:enzymology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D005958:Glucosephosphates; D007328:Insulin; D006006:Glycogen Synthase; D005947:Glucose
Stimulation de l'activité glycogène synthétase G-6-P indépendante dans le placenta humain.