Local invasion by laryngeal carcinoma--the importance of focal (metaplastic) ossification within laryngeal cartilage.
Patterns of cartilage invasion by squamous carcinoma were examined in 34 consecutive laryngectomy specimens with particular reference to selective involvement of ossified cartilage. Direct infiltration of the laryngeal framework was demonstrated in 17 cases--16 (out of 17) transglottic carcinomas and in a simgle example of a combined glottic and infraglottic tumour. The susceptibility of ossified laryngeal cartilage to tumour invasion was confirmed, and morphological studies ahve clarified the underlying mechanisms. Invasion is a largely indirect process dominated by local bone destruction by osteoclasts, operating in front of the advancing tumour. One established, carcinoma cells infiltrate and erode bone alone, and the osteoclasts disappear. Reasons for the particular susceptibility of ossified laryngeal cartilage to tumour invasion are discussed and attention is drawn to the role of the tumour-associated osteoclast activating factors such as postaglandins. Therapeutic implications of cartilage invasion are noted.
D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002357:Cartilage Diseases / Q000473:pathology; D005260:Female; D006801:Humans; D007817:Laryngeal Cartilages / Q000098:blood supply / Q000473:pathology*; D007818:Laryngeal Diseases / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009999:Ossification, Heterotopic / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology