Attempts to produce megasyndrome in mice using stocks of Trypanosoma cruzi associated with megaoesophagus in man.
Two stocks of Trypanosoma cruzi isolated from patients with advanced megaoesophagus produced megastomach in chronically infected mice. The mice showed evidence of stomach dilatation and a delay in intestinal transit time. These findings are discussed in the light of the hypothesis that regional variations in T. cruzi determines mega formation in man.
D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000150:complications* / Q000000981:diagnostic imaging; D004931:Esophageal Achalasia / Q000469:parasitology*; D005260:Female; D013271:Gastric Dilatation / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D051379:Mice; D011859:Radiography; D013270:Stomach / Q000000981:diagnostic imaging; D013577:Syndrome; D014349:Trypanosoma cruzi / Q000302:isolation & purification / Q000472:pathogenicity*