title: [Properties of the tick-borne encephalitis virus persisting for a long time in a chronically infected cell culture].
abstract: The biological properties of tick-borne encephalitis virus (Sof K) produced by chronically infected HEp-2-Sof cells at late stages of the cultivation were studied. The Sof K virus was infective for mice of different ages upon intracerebral and subcutaneous inoculation, had high immunogenicity and was completely neutralized by antiserum to the parental strain. The Sof K virus had the small-plaque phenotype and replicated with similar intensity in pig embryo cell cultures (SPEC) at 36 degrees, 42 degrees and 31 degrees C.
mesh_terms: D000818:Animals; D002478:Cells, Cultured / Q000382:microbiology*; D002908:Chronic Disease; D006224:Cricetinae; D004669:Encephalitis Viruses, Tick-Borne / Q000472:pathogenicity*; D004675:Encephalitis, Tick-Borne / Q000382:microbiology*; D000882:Haplorhini; D008251:Macaca; D008647:Mesocricetus; D051379:Mice; D013997:Time Factors; D014779:Virus Replication
vernacular_title: Svoĭstva virusa kleshchevogo éntsefalita, dlitel'no persistiruiushchego v khronicheski infitsirovannoĭ kul'ture kletok.