Studies on tetrahydrofuranyl-5-fluorouracils. 2. NMR studies of 1-(tetrahydro-2-furanyl)-, 3-(tetrahydro-2-furanyl)-, and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracils.
Measurements of the 1H NMR spectra of the diastereoisomers of 1-(tetrahydro-2-furanyl)-5-fluorouracil, 3-(tetrahydro-2-furanyl)-5-fluorouracil, and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil in the presence of tris[3-(2,2,2-trifluoro-1-hydroxyethylidene)-d-camphorato]europium(Eu(TFC)3) as a chiral shift reagent showed differences between the isomers in the chemical shift changes of the protons of C2'-H and C6-H etc.
D005472:Fluorouracil / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D013329:Structure-Activity Relationship; D005641:Tegafur / Q000031:analogs & derivatives*
D005641:Tegafur; C016882:FD 1; C025404:3-FT; D005472:Fluorouracil