title: Ovarian activity, and total gonadotrophin and gonadotrophin releasing hormone levels in response to some synthetic non-steroidal ovulating agents in the catfish, Heteropneustes fossilis (Bloch).
abstract: Effects of clomiphene citrate, cyclofenil and prostaglandins (PGE1 and PGF2 alpha) on ovarian 32P uptake, on gonadotrophin levels in the pituitary gland and blood serum and on a gonadotrophin releasing hormone-like (GnRH-like) substance in the hypothalamus were investigated in Heteropneustes fossilis. These drugs were very effective in increasing the serum level of gonadotrophin with a subsequent increase in ovarian 32P uptake in sham-hypophysectomized recipients. All the drugs except cyclofenil failed to stimulate 32P incorporation by the ovary in hypophysectomized fish. Clomiphene citrate and cyclofenil also induced a significant increase in the GnRH-like factor in the hypothalamus of H. fossilis. Such a response was not obtained in fish treated with PGE1 and PGF2 alpha. It seems likely that the action of clomiphene is routed through the hypothalamo-pituitary-ovarian axis and that of prostaglandins directly through the pituitary-ovarian axis. The action of cyclofenil is bimodal; one effect like that of clomiphene and the other direct upon the ovary probably by increasing its sensitivity to the available gonadotrophin.
mesh_terms: D000818:Animals; D002996:Clomiphene / Q000494:pharmacology; D003506:Cyclofenil / Q000494:pharmacology; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D005399:Fishes / Q000378:metabolism*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D007016:Hypophysectomy; D007031:Hypothalamus / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D005300:Fertility Agents, Female; D006065:Gonadotropins, Pituitary; D010906:Pituitary Hormone-Releasing Hormones; D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D014020:Tissue Extracts; D002996:Clomiphene; D010758:Phosphorus; D003506:Cyclofenil