Vitamin D binding globulin phenotypes in liver disease.
The binding properties towards vitamin D metabolites of plasma from individuals with the three common Gc-globulin phenotypes, Gc-1, Gc-2 and Gc-2-1, have been found to be identical. In patients with liver disease there is a good correlation between the levels of Gc-globulin andalbumin in plasma. In addition the Gc-globulin levels correlate well with the ability of plasma to bind 25-hydroxycholecalciferol. Patients with the Gc-2-1 phenotype showed a significantly smaller depression in plasma Gc-globulin than those with the Gc-2 and Gc-1 phenotypes. The relation of these findings to the pathogenesis of disorders of calcium metabolism in liver disease is discussed.
D000510:Alpha-Globulins / Q000097:blood / Q000235:genetics*; D002128:Calcium Metabolism Disorders / Q000209:etiology; D002352:Carrier Proteins; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000150:complications / Q000235:genetics*; D010641:Phenotype; D012709:Serum Albumin / Q000235:genetics; D014807:Vitamin D / Q000378:metabolism*
D000510:Alpha-Globulins; D002352:Carrier Proteins; D012709:Serum Albumin; D014807:Vitamin D