[Anti-D hyperimmunoglobulin, a study of Swiss requirements].
Owing to the introduction of postpartum Rhesus prophylaxis with anti-D hyperimmunoglobulin, a very small number of Rh-negative women become sensitized against the Rhesus factor at birth. Accordingly, the number of naturally immunized women suitable for the collection of anti-D plasma is decreasing. Currently, the demand for anti-D plasma in Switzerland is covered by plasma donations of spontaneously immunized women. The relation between production of and demand for anti-D hyperimmunoglobulin is expected to improve in the coming years due to better registration of anti-D-carrying women. Large areas of Switzerland are poorly exploited with regard to female anti-D donors and represent substantial reserves with regard to anti-D hyperimmunoglobulin production. It is expected that anti-D production from plasma collected from naturally sensitized women will cover demands up to the year 2000 without difficulty. Active immunization of Rh-negative volunteer donors will not be needed before the end of the century.
D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000627:therapeutic use*; D010956:Plasmapheresis; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System; D013557:Switzerland
D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System
Hyperimmunoglobulin Anti-D, eine schweizerische Bedarfsstudie.