[Lymphocyte subpopulations in adjuvant arthritis of rats. Effects of corticoids and gamma irradiation].
Experimental model of human chronic inflammatory arthritis, adjuvant arthritis may be induced only in several strains of inbred Rats: it is well developed in LEW and practically absent in WAG. After adjuvant injection, the PHA-stimulable lymphocytes subpopulation quite disappears from the blood, if polyarthritis is well developed. These cells are probably capted in the tissues implicated in immunological conflict. On the contrary, the ConA-stimulable subpopulation is enhanced in both strains after adjuvant injection, earlier and more intense in WAG than in LEW and that phenomenon is probably linked to a stimulation of suppressor T lymphocytes. Treatment with prednisone or gamma rays inhibits partially and delays the appearance of arthritis in LEW, acting essentially on ConA-stimulable subpopulation.
D000276:Adjuvants, Immunologic; D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology* / Q000517:prevention & control; D003208:Concanavalin A / Q000494:pharmacology; D005720:Gamma Rays; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew / Q000276:immunology; D011919:Rats, Inbred Strains / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D037102:Lectins; D003208:Concanavalin A; D011241:Prednisone
Etude des sous-populations de lymphocytes dans la polyarthrite à adjuvant de rat. Effet des corticoïdes et del l'irradiation gamma.