title: The effect of polyunsaturated fats on bile acid metabolism and cholelithiasis in squirrel monkeys.
abstract: Squirrel monkeys (Saimiri sciureus) were fed diets containing safflower oil, butter, or coconut oil and 1 mg cholesterol/cal for 15--17 mo to examine the effect of type of fat on cholelithiasis and bile acid metabolism. Controls were fed low cholesterol diets containing an isocaloric mixture of the three fats. Cholic acid fractional catabolic rate, pool size, chenodeoxycholic acid pool size, and total bile acid pool size and excretion rate were estimated using a modification of Lindstedt's isotopic turnover procedure. The animals fed the safflower oil diet had the highest incidence of cholelithiasis (9/10) when compared to those fed butter (3/7) and coconut oil (1/7). Animals consuming the low cholesterol control diet did not develop gallstones. The butter- and coconut oil-fed groups had significantly (p less than 0.05) expanded bile acid pools when compared to controls, and the butter-fed group had a significantly increased (p less than 0.05) cholic acid fractional catabolic rate. The safflower oil group had the smallest mean bile acid pool and the highest mean lithogenic index of the cholesterol-fed groups. It was concluded that the safflower oil-fed animals had a higher incidence of cholelithiasis than the butter group because, unlike the latter group, they did not compensate for a high cholesterol intake by stimulating bile acid synthesis. The animals consuming coconut oil apparently did not absorb cholesterol to the extent of the other groups and as a result their bile did not become saturated with cholesterol.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002079:Butter / Q000009:adverse effects; D002769:Cholelithiasis / Q000209:etiology* / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000378:metabolism; D003059:Cocos; D004041:Dietary Fats / Q000009:adverse effects; D005224:Fats, Unsaturated / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D000882:Haplorhini; D009821:Oils; D012450:Safflower Oil / Q000009:adverse effects; D012453:Saimiri
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005224:Fats, Unsaturated; D009821:Oils; D012450:Safflower Oil; D002079:Butter