[Early effect of estradiol on ultrastructure of chromatin in the endometrium and hormone-dependent mammary tumors].
After in vivo and in vitro administration of aestradiol, the chromatin of lamb endometrium and of hormone-dependent 7,12-dimethylbenzanthracene Rat mammary tumors is rapidly transformed from a condensed into a diffuse chromatin. A stimulation of 3H leucine incorporation into protein was also observed. These modifications were specific for estrogen receptor ligands and for estrogen responsive tissues. In vitro tamoxifen induced pycnosis. These changes could be used to improve the prediction of hormone dependency of human breast and uterine cancers.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000648:ultrastructure; D000818:Animals; D002843:Chromatin / Q000187:drug effects* / Q000648:ultrastructure; D013196:Dihydrotestosterone / Q000494:pharmacology; D004717:Endometrium / Q000648:ultrastructure*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006570:Heterochromatin / Q000187:drug effects; D066298:In Vitro Techniques; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000648:ultrastructure*; D009376:Neoplasms, Hormone-Dependent / Q000139:chemically induced / Q000648:ultrastructure*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects; D012756:Sheep; D013629:Tamoxifen / Q000494:pharmacology; D013997:Time Factors
D002843:Chromatin; D006570:Heterochromatin; D011960:Receptors, Estrogen; D013196:Dihydrotestosterone; D013629:Tamoxifen; D011374:Progesterone; D004958:Estradiol; D015127:9,10-Dimethyl-1,2-benzanthracene
Effet précoce de l'aestradiol sur l'ultrastructure de la chromatine dans l'endomètre et les tumeurs mammaires hormonodépendantes.