Urinary proline to hydroxyproline ratio varies with age.
Urinary excretion of proline and hydroxyproline was studied in five groups of subjects, viz. controls, pituitary dwarfs, familial dwarfs, patients with fibrodysplasia ossificans progressive and patients with generalized scleroderma. The ratio Pro/Hyp in the urinary fraction precipitated with 5 parts of acetone (1 + 5 fraction) was close to one in children and youngsters in all the groups, while in adults it was higher than two. Total Pro/Hyp does not give an accurate index of age.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D004392:Dwarfism / Q000652:urine; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D009221:Myositis Ossificans / Q000652:urine; D011392:Proline / Q000652:urine*; D012595:Scleroderma, Systemic
D011392:Proline; D006909:Hydroxyproline