title: Impairment of hepatic mixed-function oxidase activity by alpha- and beta-naphthylisothiocyanate: relationship to hepatotoxicity.
mesh_terms: D015058:1-Naphthylisothiocyanate / Q000494:pharmacology* / Q000633:toxicity; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D006224:Cricetinae; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013861:Thiocyanates / Q000494:pharmacology*
chemical_list: D013861:Thiocyanates; D015058:1-Naphthylisothiocyanate; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D014453:Glucuronosyltransferase; D001219:Aspartate Aminotransferases; D001663:Bilirubin