Persistence and reactivation of Rickettsia tsutsugamushi infections in laboratory mice.
The persistence of R. tsutsugamushi in tissues of experimentally infected mice for 565 days was demonstrated. Reactivation of apparently dormant infections was accomplished by inoculating the mice with a heterologous strain of the organism or treatment with cyclophosphamide.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D007165:Immunosuppression Therapy; D051379:Mice; D012285:Orientia tsutsugamushi / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology; D012008:Recurrence; D012612:Scrub Typhus / Q000276:immunology*
D000907:Antibodies, Bacterial; D003520:Cyclophosphamide