title: [Effect of a dinitro-o-cresol-containing herbicide (Hedolit) on human reproduction].
abstract: After epicutaneous application of Hedolit to guinea pigs the above mentioned substance was found less concentrated in the semen and in the testis than in the serum. Hedolit concentrations, as they were found in the serum, lead already to motility limitations of human sperma and cause a small mutageneous effect in drosophila melanogaster. The chosen epicutaneous modus of application did not lead to such traceable concentrations of Hedolit in the semen and in the testis.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003408:Cresols / Q000633:toxicity*; D004138:Dinitrocresols / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster; D006168:Guinea Pigs; D006540:Herbicides / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009153:Mutagens; D012098:Reproduction / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013997:Time Factors
chemical_list: D003408:Cresols; D004138:Dinitrocresols; D006540:Herbicides; D009153:Mutagens; C024132:4,6-dinitro-o-cresol
vernacular_title: Uber den Einfluss eines Dinitro-o-kresol-haltigen Pflanzenschutzmittels (Hedolit) auf die menschliche Reproduktion.