[Change in the envelope of a murine retrovirus produced in the presence of toyocamycin].
Toyocamycin (TMC), an adenosine analog, impairs qualitatively and quantitatively virus production in a cellular system chronically infected by Friend Virus. Viral particles released by cell cultures treated with 0.2 microgram/ml of the drug have lost most of their glycoprotein (gp 70) content. This phenomenon is likely to modify the viral envelope and could explain the loss of infectivity of the virus.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D005944:Glucosamine / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D051379:Mice; D010455:Peptides / Q000378:metabolism; D012190:Retroviridae / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D014127:Toyocamycin / Q000494:pharmacology*; D014764:Viral Proteins / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D006023:Glycoproteins; D010455:Peptides; D014764:Viral Proteins; D014127:Toyocamycin; D005944:Glucosamine
Modification de l'enveloppe d'un retrovirus murin synthétisé en présence de toyocamycine.