title: In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents.
abstract: The binding of sodium aurothiomalate, sodium aurothiosulphate and aurothioglucose to plasma proteins has been  investigated in vitro. All gold compounds were bound to protein at a similar rate and had similar apparent affinity constants and binding capacities. Penicillamine (10 or 100 microgram/ml) was unable to chelate significant amounts of bound gold from plasma protein.
mesh_terms: D006051:Aurothioglucose / Q000378:metabolism; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism*; D002614:Chelating Agents / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006046:Gold / Q000378:metabolism*; D006052:Gold Sodium Thiomalate / Q000378:metabolism; D012971:Gold Sodium Thiosulfate / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D010396:Penicillamine / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D002614:Chelating Agents; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D006046:Gold; D012971:Gold Sodium Thiosulfate; D010396:Penicillamine