[Electron microscopic aspects of opportunistic fungi after pretreatment].
The ultrastructive of Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger was studied when treated in vitro with 0.001, 0.01 and 0.1% econazole nitrate and econazole base. The very first morphological alterations appear faster than in normal-growing fungus and consist in a convoluted cytoplasmic membrane, large mesosomes and lomasomes and an extensive vacuolization. Acid phosphatase is found in the mesosomes and lomasomes and also in the center of the vacuoles. This is an early sign of fungus degradation.
D000135:Acid Phosphatase / Q000378:metabolism; D001231:Aspergillus flavus / Q000187:drug effects* / Q000648:ultrastructure; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000648:ultrastructure*; D001234:Aspergillus niger / Q000187:drug effects* / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004464:Econazole / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D014617:Vacuoles / Q000648:ultrastructure
D007093:Imidazoles; D004464:Econazole; D000135:Acid Phosphatase
Aspects électron-optiques de la thérapeutique des champignons opportunistes.