Oral progestational activity of spironolactone.
Spironolactone has progestational activity in the rabbit and rhesus monkey. It produced glandular development in the endometrium of the estrogen-primed immature female rabbit over the dosage range of 50 to 200 mg/kg and, at 400 mg/monkey, it delayed estrogen-withdrawal bleeding in ovariectomized monkeys and it inhibited menstruation in regularly cycling monkeys. These data are consistent with the menstrual irregularity and amenorrhea seen in women during treatment with spironolactone.
D000818:Animals; D002369:Castration; D002715:Chlormadinone Acetate / Q000494:pharmacology; D004717:Endometrium / Q000187:drug effects / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008253:Macaca mulatta; D008598:Menstruation / Q000187:drug effects; D011372:Progestins; D011817:Rabbits; D013148:Spironolactone / Q000494:pharmacology*
D011372:Progestins; D002715:Chlormadinone Acetate; D013148:Spironolactone; D004958:Estradiol