title: Physiological and histological effects of cerebellar stimulation.
abstract: Cerebellar implants have been placed in 62 patients with postoperative follow-up of 4 months to 3 years. Initially currents were applied through electrodes of alternate polarity on the superior surface of the cerebellar hemispheres and subsequently through negative electrodes on the superior surface to positive electrodes on the posterior surface. The amount of current required for clinical improvement was approximately the same as that required to significantly reduce the amplitude of the somatosensory evoked potential. The clinical and electrophysiological effects were proportional to the intensity of current and to the number of electrodes through which the currents were applied. Currents applied through the cerebellum were more effective than those confined near the cerebellar surface. Histological examination of the cerebellum from the chimpanzees and from 1 patient who died of causes unrelated to stimulation failed to demonstrate any evidence of neuronal damage related to application of current.
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D002526:Cerebellar Diseases / Q000209:etiology; D002531:Cerebellum; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods; D004567:Electrodes, Implanted; D005071:Evoked Potentials; D000882:Haplorhini; D006801:Humans; D009128:Muscle Spasticity / Q000503:physiopathology / Q000628:therapy*; D002679:Pan troglodytes; D011689:Purkinje Cells / Q000503:physiopathology