[The effect of intermittent hypoxia on leukocyte function in puppies in the first month of life].
In experiments on puppies of the first month of postnatal life, subjected to intermittent oxygen deficiency (2 hours of simulated altitude of 8.000 m daily within 12 days), studies have been made on the number of leucocytes in 1 mm3 of the peripheral blood, leucocyte formula, phagocytic and motor activities of mature neutrophils, their glycogen content, vacuolization degree and osmotic fragility. Age changes were found in the reaction of leucocytic system to intermittent hypoxia. In contrast to adult dogs, puppies react already to 3 and 6 exposures to hypoxia by the decrease of absolute content of phagocytes, phagocytic and motor activities of neutrophils. These changes are presumably due to immaturity of functional mechanisms of regulation of the blood system at the given stage of postnatal ontogenesis.
D000375:Aging / Q000097:blood*; D000818:Animals; D001273:Atmosphere Exposure Chambers; D004285:Dogs; D000860:Hypoxia / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D009997:Osmotic Pressure; D010587:Phagocytosis; D013997:Time Factors
Vliianie preryvistoĭ gipoksii na funktsional'nuiu aktivnost' leĭkotsitov u shchenkov pervogo mesiatsa zhizni.