The use of antithyroid therapy in the treatment of neoplastic conditions with cytotoxic drugs.
Taking into account the known actions of thyroid hormone, we suggest that standard antithyroid therapy may be used to create a situation of greater sensitivity to cytotoxic drugs in tumour tissues as compared with normal tissues.
D000818:Animals; D000970:Antineoplastic Agents; D013956:Antithyroid Agents / Q000627:therapeutic use*; D001853:Bone Marrow / Q000187:drug effects; D004357:Drug Synergism; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy*; D014176:Protein Biosynthesis; D051381:Rats; D013963:Thyroid Hormones / Q000378:metabolism
D000970:Antineoplastic Agents; D013956:Antithyroid Agents; D013963:Thyroid Hormones