Comparison of the effects of 11-palmitoyloxy-delta 9-tetrahydrocannabinol with delta 9-tetrahydrocannabinol and 11-hydroxy-delta 9-tetrahydrocannabinol on the hepatic microsomal drug-metabolizing enzyme system.
Delta 9-THC and 11-OH-delta 9-THC appear to in vivo affect the metabolism of both Type I and Type II substrates involving cytochrome P-450 as well as to affect the metabolism of a substrate requiring cytochrome P-448. These effects could not be observed significantly in in vitro experiments at the concentrations used. 11-Palmitoyloxy-delta 9-THC does not appear to affect the metabolism of either Type I or Type II substrates but does appear to affect those substrates requiring P-448. From these studies it appears that long-retained delta 9-THC metabolite 11-palmitoyloxy-delta 9-THC, as well as delta 9-THC and 11-OH-delta 9-THC, could alter in vivo the metabolism and activity of certain drugs and other foreign compounds.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats
D011506:Proteins; D013759:Dronabinol; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D009251:NADPH-Ferrihemoprotein Reductase