Effect of irradiation on the feto-placental tissues.
Seven pregnant patients with genital carcinoma were treated with high voltage irradiation in combination with operation. Five patients aborted spontaneously after a dose of 30 to 34 Gy. Two were operated within 2 weeks after completed irradiation. Angiography, microscopy and hormone analyses indicate that damage of the fetal central nervous system and not placental insufficiency is responsible for the intrauterine fetal death.
D000032:Abortion, Therapeutic; D000230:Adenocarcinoma / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005333:Fetus / Q000528:radiation effects*; D006801:Humans; D008431:Maternal-Fetal Exchange; D010051:Ovarian Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D010920:Placenta / Q000528:radiation effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000532:radiotherapy* / Q000601:surgery; D011882:Radiotherapy, High-Energy; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D014599:Uterus / Q000528:radiation effects*
D003037:Cobalt Radioisotopes