Two HLA-D and DR alleles are associated with coeliac disease.
A group of 45 children affected with Coeliac Disease (CD) was typed for HLA-A, B, C, D, and DR specificities. The most significant associations were found with two alleles of the D series, with both cellular and serological typing. It is suggested that the susceptibility to CD is determined by two different genes within the HLA region, the first in common with organ-specific autoimmune diseases and associated with DW3, the second possibly specific for CD and associated with Dw7.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002446:Celiac Disease / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D005260:Female; D005787:Gene Frequency; D005796:Genes; D006680:HLA Antigens / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D010641:Phenotype
D000939:Epitopes; D006680:HLA Antigens