title: Comparative metabolism of the amphetamine drugs of dependence in man and monkeys.
abstract: The use of animal models to study drug dependence and tolerance requires that the species used metabolizes the drugs like man, a condition frequently not fulfilled by non-primate species. The metabolic fate of several amphetamine drugs, namely amphetamine, norephedrine, chlorphentermine and phenmetrazine, in the rhesus monkey and the tamarin and two non-primate species has been investigated and compared to that found for man. The findings show that the two primate species metabolize these drugs in a manner similar to that in man.
mesh_terms: D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D002143:Callitrichinae / Q000378:metabolism; D002745:Chlorphentermine / Q000378:metabolism; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta / Q000378:metabolism; D010633:Phenmetrazine / Q000378:metabolism; D010665:Phenylpropanolamine / Q000378:metabolism; D011817:Rabbits; D051381:Rats
chemical_list: D000662:Amphetamines; D010665:Phenylpropanolamine; D002745:Chlorphentermine; D010633:Phenmetrazine