title: [Analysis of results with Depamide in children with psychomotor instability (hyperkinesis (author's transl)].
abstract: This study results from observations, for 10 years, of children with psychomotor instability, also called hyperkinesis, generally due to "minimal brain dysfunction". A clinical summary emphasizes instability and difficult coordination of all aspects of personality. A pathogenic hypothesis concerns one of the stimulation function which may be abnormal, as the control and regulation of personality, partly located, at the subcortical level, and creating secondary symptoms and reactional ones. The results of therapy are interpreted according to a clinical research protocol. It proposes a global appreciation, an appreciation of the duration of therapeutic effect through the study of variation of specific criteria, and a general appreciation correlating both aspects. Through this stern methodology and the mean duration of treatment of 2 years, the results are significant in 55% of the cases. Compared to other drugs, Depamide seems more valid. Furthermore, this drug is without secondary clinical and psychological effects.
mesh_terms: D002648:Child; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy*; D008297:Male; D010552:Personality Assessment; D012189:Retrospective Studies; D013997:Time Factors; D014635:Valproic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D014635:Valproic Acid; C004651:dipropylacetamide
vernacular_title: Analyse des résultats obtenus avec le Dépamide chez des enfants atteints d'instabilité psychomotrice (hyperkinésie).