title: The effect of prophylactic tinidazole on the anaerobic vaginal flora in patients undergoing gynaecological surgery.
abstract: The effects of prophylactic tinidazole on the vaginal carrier state of anaerobic bacteria and the development of postoperative infections were studied in 50 patients undergoing gynaecological surgery. The results are based on a double-blind trial, using tinidazole (Fasigyn; Pfizer) and placebo. Although no postoperative infections other than urinary tract infections were observed in our series, this study shows conclusively that the isolation of anerobic bacteria from the vagina decreased markedly in the tinidazole group compared with the placebo group.
mesh_terms: D001424:Bacterial Infections / Q000517:prevention & control*; D002584:Cervix Uteri / Q000601:surgery; D004311:Double-Blind Method; D004341:Drug Evaluation; D013293:Enterococcus faecalis / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007710:Klebsiella Infections / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011184:Postoperative Period; D011512:Proteus Infections / Q000517:prevention & control; D011513:Proteus mirabilis / Q000302:isolation & purification; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013290:Streptococcal Infections / Q000517:prevention & control; D014011:Tinidazole / Q000627:therapeutic use*; D014621:Vagina / Q000382:microbiology* / Q000601:surgery
chemical_list: D009593:Nitroimidazoles; D014011:Tinidazole