[Microsomal oxygenase enzyme system during chronic administration of 2-acetylaminofluorene].
Alteration in content of enzymatic components was studied in microsomal oxygenases system of rats administered with 2-acetyl aminofluorene. Content of cytochrome R-450 was decreased beginning from the fourth week of the experiment. Activity of NADP cytochrome c reductase was higher in animals, treated with the drug as compared with controls. Inductors of the I and II type were capable to induce the enzymatic system up to the end of the experiment - within 16 weeks as far as liver tumors developed.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003579:Cytochrome Reductases / Q000096:biosynthesis*; D003580:Cytochromes / Q000096:biosynthesis*; D004790:Enzyme Induction; D005449:Fluorenes / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000096:biosynthesis*; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D002273:Carcinogens; D003580:Cytochromes; D005449:Fluorenes; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D015073:2-Acetylaminofluorene; D003579:Cytochrome Reductases; D009251:NADPH-Ferrihemoprotein Reductase; D010634:Phenobarbital
Izuchenie sostoianiia fermentnoĭ sistemy mikrosomal'nykh oksigenaz pri khronicheskom vvedenii 2-atsetilaminofluorena.