title: Conformational requirements at the prostaglandin cyclooxygenase receptor site: a template for designing non-steroidal anti-inflammatory drugs.
abstract: When space-filling models of the peroxy radical precursor of PGG were compared with models of 2(S)-(3-chloro-4-cyclohexylphenyl) propionic acid and other acidic cyclooxygenase inhibitors several common structural features were revealed. This led us to propose a template for designing non-steroidal anti-inflammatory drugs (NSAID's) based on the conformation of the peroxy radical immediately prior to its cyclisation to PGG. The template can be equated with a complementary cyclooxygenase receptor site.
mesh_terms: D000893:Anti-Inflammatory Agents; D001665:Binding Sites; D016861:Cyclooxygenase Inhibitors; D008958:Models, Molecular; D010666:Phenylpropionates; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011462:Prostaglandins G; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D010666:Phenylpropionates; D011462:Prostaglandins G; D011451:Prostaglandin-Endoperoxide Synthases