[Effect of a combination of 3 pesticides on the sensitization of guinea pigs to ovalbumin].
The author treated guinea pigs with a combination of three pesticides: First group -- with cyneb in a dose of 12,5 mg/kg of body weight (threshold value) +/- sevine in a dose of Ip 5 mg/kg (twice threshold value) +/- tribufon in a dose of 5.0 mg/kg (threshold value); second group -- cyneb 125 mg/kg (ten times of threshold value) +/- sevine 1.5 mg/kg (twice the threshold value) +/- tribufon 5.0 mg/kg (threshold value). Two groups of animals were used as controls: first group-- treated with 2,0 mg/kg of cyclophosphamide and second group -- with 3% of starch emulsion, with which other substances were given. The indicated substances were administered in the animals by a probe (a catheter) daily, in the morning before feeding, for a period of six months. Then sensibilization was made by ovalbumin in a solution of 10 gm% according the scheme: first injection of 2 ml of ovalbumin -- 1 ml subcutaneously in the inguinal region and 1 ml intraperitonealy. A challenging dose of 2 ml was administered inraperitonealy after 20 days and the reaction of the experimental animals was examined for a period of 90 minutes after the administration of the challenging dose. There was no difference in the reaction of the guinea pigs, treated with a combination of three pesticides in comparison with animals, given the same pesticides in the same dosage, but singly.
D000818:Animals; D012721:Carbaryl / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D007306:Insecticides / Q000276:immunology; D008297:Male; D009943:Organophosphorus Compounds; D010047:Ovalbumin / Q000276:immunology*; D010575:Pesticides / Q000276:immunology*; D013997:Time Factors; D015038:Zineb / Q000276:immunology
D004338:Drug Combinations; D007306:Insecticides; D009943:Organophosphorus Compounds; D010575:Pesticides; D010047:Ovalbumin; D012721:Carbaryl; D015038:Zineb
Vliianie na kombinatsiia ot tri pestitsida vurkhu sensibilizatsiiata na morski svincheta s ovalbumin.