[Vitamin E activity of some alpha-tocopherol derivatives and their effect on the ubiquinone level in rat liver in vitro].
An addition of alpha-tocopherol (I) and its synthetic derivatives (alpha-tocopheryl quinone (II), its short-chained analog (III), alpha-tocopherol lactone (IV), and short-chained alpha-tocopheryl acetate (V)) to the homogenized liver of vitamin E deficient rats resulted in a significant increase of ubiquinone after 2 hour incubation. Activity of the above derivatives (II-V) was not associated directly with their transformation into I or with a noticeable increase of the I content. There is a certain correlation between the chemical structure and the level of vitamin E activity of alpha-tocopherol derivatives that led to an increase in the ubiquinone content and prevented the decrease of tissue respiration and termination of pregnancy in rats.
D000034:Abortion, Veterinary; D000818:Animals; D005260:Female; D008099:Liver / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014451:Ubiquinone / Q000378:metabolism*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism
D014451:Ubiquinone; D014810:Vitamin E; D010100:Oxygen
E-vitaminnaia aktivnost' nekotorykh proizvodnykh alpha-tokoferola i vliianie ikh na soderzhanie ubikhinona v pecheni krys in vitro.