Effects of benzazepine (Sch-12679) on shock-induced fighting and locomotor behavior in rats.
Benzazepine (Sch-12679) reduced the shock-induced fighting behavior of rats in a dose-dependent fashion. However, the drug also impaired both locomotor behavior and rotorod performance. These results suggest that the aggression suppressive effects of Sch-12679 may be mediated by drug-induced sedation.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004597:Electroshock; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats
D001552:Benzazepines; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; C001016:trimopam