Benzo[alpha]pyrene antibody inhibition of benzo[alpha]pyrene-induced mutageneis.
An antibody to benzo[alpha]pyrene (BP) was prepared. The isolated antibody showed a specificity for BP and a low reactivity with another carcinogenic hydrocarbon, 7,12-dimethylbenz[alpha]anthracene (DMBA). The BP-antibody inhibited the in vitro cytotoxic and mutagenic activity of BP in both a rat embryo fibroblast- and a rat lung cell-mediated mutagenesis system. A possible correlation of these in vitro findings to the in vivo carcinogenesis situation is discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000276:immunology; D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D001580:Benzopyrenes / Q000037:antagonists & inhibitors / Q000276:immunology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D005260:Female; D005347:Fibroblasts; D008168:Lung; D009153:Mutagens; D051381:Rats
D000906:Antibodies; D001580:Benzopyrenes; D009153:Mutagens; D015127:9,10-Dimethyl-1,2-benzanthracene