Effect of phenytoin on protein binding of valproic acid.
In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.
D006801:Humans; D010672:Phenytoin / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D014635:Valproic Acid / Q000097:blood*
D014635:Valproic Acid; D010672:Phenytoin