Effect of staphylococcal enterotoxin B on cardiorenal functions and survival in X-irradiated rhesus macaques.
Pretreatment of rhesus macaques with nonlethal total-body x-irradiation (400 R) prolonged survival time from an average of 15 hours to 101 hours after intravenous (IV) inoculation of 50 microgram of staphylococcal enterotoxin B (SEB)/kg of body weight. Radiation exposure per se did not produce detectable cardiorenal changes; however, the longer survival after SEB challenge exposure in x-irradiated rhesus macaques was associated with improved cardiorenal functions if compared with that of nonirradiated macaques given the same dose of SEB. Total-body radiation exposure 4 days prior to IV SEB inoculation prevented typical SEB-induced decreases (where measured at 5 hours) in cardiac output, stroke volume, TcH2O, CPAH, Cosm, and urine flow, as well as increases in total peripheral and renal resistance. A theory concerning the significance of radiation-induced leukopenia on modification of SEB-induced cardiorenal functions is postulated.
D000818:Animals; D002302:Cardiac Output; D004768:Enterotoxins / Q000633:toxicity*; D005260:Female; D000882:Haplorhini; D006321:Heart / Q000503:physiopathology* / Q000528:radiation effects; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology* / Q000528:radiation effects; D008251:Macaca; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000139:chemically induced / Q000503:physiopathology*; D012039:Regional Blood Flow; D013210:Staphylococcus; D014655:Vascular Resistance; D014965:X-Rays
D004768:Enterotoxins