A study of rabbit plasma progressive antithrombinic activity during acute phase inflammatory reaction and in experimental nephrotic syndrome.
1. The development of the progressive antithrombinic activity in rabbit plasma as a function of the level of the two alpha-macroglobulins in two experimental pathologies: acute phase inflammatory reaction and nephrotic syndrome, were studied. 2. In the first case, the antithrombinic activity is a result of the increased biosynthesis of plasmatic antithrombins: antithrombin III, alpha 1 antitrypsin and alpha macroglobulins. 3. In the nephrotic syndrome, this activity follows the increase in the alpha M levels, the other antithrombins having been massively eliminated from the circulation in the urine.
D000818:Animals; D000991:Antithrombins / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis; D006207:Half-Life; D007249:Inflammation / Q000097:blood*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D009961:Orosomucoid / Q000032:analysis; D011817:Rabbits; D000511:alpha-Macroglobulins / Q000032:analysis*
D000991:Antithrombins; D009961:Orosomucoid; D000511:alpha-Macroglobulins; D005340:Fibrinogen