Degradation of myelin basic protein by cerebrospinal fluid: preservation of antigenic determinants under physiological conditions.
Cerebrospinal fluid contains several proteolytic enzymes that can degrade myelin basic protein (BP) under physiological conditions into peptide fragments of various sizes which still contain antigenic determinants capable of binding antibodies to BP. These enzymes are optimally active in either acid (pH 4) or nuetral (pH 7 to 8) conditions and can be characterized by the nature of the BP peptide fragments produced. Proteinases resembling cathepsin D, thrombin, plasmin (fibrinolysin), or kallikrein are present in variable amounts in CSF. No relationship to any particular disease has yet been established.
D002403:Cathepsins; D000939:Epitopes; D005341:Fibrinolysin; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007610:Kallikreins; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid* / Q000276:immunology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D010447:Peptide Hydrolases / Q000134:cerebrospinal fluid*; D013917:Thrombin
D000939:Epitopes; D004676:Myelin Basic Protein; D002403:Cathepsins; D010447:Peptide Hydrolases; D007610:Kallikreins; D013917:Thrombin; D005341:Fibrinolysin