Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes.
Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.
D000150:Acinetobacter / Q000378:metabolism*; D000215:Acylation; D000935:Antifungal Agents; D005658:Fungi / Q000187:drug effects; D006868:Hydrolysis; D009089:Mucor / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*; D013045:Species Specificity; D013305:Streptomyces griseus / Q000378:metabolism*; D014255:Trichothecenes / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology
D000935:Antifungal Agents; D012717:Sesquiterpenes; D014255:Trichothecenes