Ontogeny, cell distribution, and the physiological role of NADP-malic enxyme in Drosophila melanogaster.
NADP-malic enzyme (NADP-ME) (E.C. 1.1.1.40) is situated in the cytosol of Drosophila melanogaster. Both the tissue activity and CRM level of NADP-ME parallel changes in the dosage of a gene, Men+, located in region 87C2-3 to 87D1-2 of the third chromosome. The tissue activity of NADP-ME is very high in early third instar larvae, providing about 33% of the NADPH at this life stage. The tissue activity declines during pupal development but increases as the adult ages. The concentration of NADP-ME CRM and tissue activity are coordinately increased in third instar larvae by dietary carbohydrate and decreased by dietary lipid.
D000818:Animals; D004261:DNA Replication; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000502:physiology*; D005796:Genes; D008291:Malate Dehydrogenase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008675:Metamorphosis, Biological
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D008291:Malate Dehydrogenase