Inherited chi chain polymorphism in mouse antibodies to phenyloxazolone.
Mice of several but not all strains produce antibodies of restricted heterogeneity (public idiotype) against hapten 2-phenyl-oxazolone (phOx). This public idiotype is controlled by an allotype-linked gene in crosses between BALB/c and C57BL mice. RF mice do not produce the idiotype although allotype c strain, DBA/2, does. We studied whether the RF strain is negative for the idiotype because of an unsuitable H chain repertoire or an unsuitable L chain repertoire. Our breeding experiments indicate that the H chain repertoire of RF mice can support synthesis of the public idiotype but the L chain repertoire cannot.
D000483:Alleles; D000818:Animals; D000906:Antibodies / Q000235:genetics*; D001666:Binding Sites, Antibody; D003433:Crosses, Genetic; D005260:Female; D006579:Heterozygote; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010080:Oxazoles / Q000276:immunology*; D010081:Oxazolone / Q000276:immunology*; D011110:Polymorphism, Genetic
D000906:Antibodies; D007143:Immunoglobulin Heavy Chains; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D010080:Oxazoles; D010081:Oxazolone