title: [In vitro inhibition of tRNA methyltransferases by queen substance, a pheromone of queen honeybees].
abstract: The Queen Substance 1, a pheromone of the queen Honeybee Apis mellifica is an in vitro inhibitor of E. coli B tRNA methylations. This activity is not specific of the methylase source, as inhibitions have been observed with preparations from queen honeybee ovaries, Rat liver or a Mouse plasmocytoma 1-adenine methylase. These results, together with preceding ones concerning t, t-farnesyl-acetone 3, are discussed.
mesh_terms: D000818:Animals; D001516:Bees / Q000502:physiology*; D004926:Escherichia coli / Q000201:enzymology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D007651:Keto Acids / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D010053:Ovary / Q000201:enzymology; D010675:Pheromones / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D012359:tRNA Methyltransferases / Q000037:antagonists & inhibitors*
chemical_list: D005231:Fatty Acids, Unsaturated; D007651:Keto Acids; D010675:Pheromones; D012359:tRNA Methyltransferases
vernacular_title: Inhibition in vitro de tRNA méthyltransférases par la Substance Royale, phéromone des reines d'Abeilles.