title: Demonstration of the intermediate cells of Billingham and Medawar in the epidermis of Macaca mulatta and rhesus monkey.
abstract: The digest of the pure epidermis preparation from Macaca mulatta demonstrated three types of dendritic cells i.e. (1) dopa-positive melanocytes, (2) dopa-negative Langerhans' cells and (3) weakly dopa-positive intermediate cells of Billingham and Medawar. The last type of cell was found to have characteristics being intermediate between those of the melanocytes and of the Langerhans' cell. A similar digest prepared from the epidermis of the rhesus monkey demonstrated isomorphous dendritic cells which were all dopa-negative. Here also the intermediate cells of Billingham and Medawar with characteristics intermediate between those of the melanocytes and of the Langerhans' cells were identified.
mesh_terms: D000818:Animals; D002467:Cell Nucleus; D003712:Dendrites; D004295:Dihydroxyphenylalanine; D000078404:Epidermal Cells; D000882:Haplorhini; D007801:Langerhans Cells / Q000166:cytology; D008251:Macaca / Q000033:anatomy & histology*; D008253:Macaca mulatta / Q000033:anatomy & histology*; D008544:Melanocytes / Q000166:cytology
chemical_list: D004295:Dihydroxyphenylalanine