Neurofibromatosis in childhood.
A study of 78 children with neurofibromatosis showed that 40% had an autosomal dominant form of inheritence and a wide variety of manifestations which developed at varying stages during childhood. The pattern of these manifestations differed in many respects from the pattern seen in adults with neurofibromatosis. As a result of our inability to predict the future appearance of these manifestations and the difficulty encountered in treating advanced lesions, it is suggested that a policy of early detection and treatment is advisable. This applies particularly to intrathoracic neurofibromas, tumours of the optic nerves, spinal cord and brain, and kyphoscoliosis.
D001859:Bone Neoplasms / Q000175:diagnosis; D001932:Brain Neoplasms / Q000175:diagnosis; D002648:Child; D000013:Congenital Abnormalities / Q000150:complications; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D009901:Optic Nerve Diseases / Q000175:diagnosis; D012878:Skin Neoplasms / Q000175:diagnosis; D012983:Soft Tissue Neoplasms / Q000175:diagnosis; D013120:Spinal Cord Neoplasms / Q000175:diagnosis