Parenteral acyclovir therapy for herpesvirus infections in man.
Acyclovir is a new antiviral agent which is highly active against herpesviruses in vitro and in laboratory animals. Twenty-three cancer patients with cutaneous and/or systemic herpes zoster or herpes simplex infections were treated with parenteral acyclovir. All had received previous specific treatment for their malignant disease and ten had undergone bone-marrow transplantation. The drug seemed to arrest the progress of the infections and was most effective when given early. Although two patients showed transient increases in blood-urea, possibly the result of acyclovir, the drug was remarkably non-toxic in the doses used.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000633:toxicity; D002644:Chickenpox / Q000188:drug therapy*; D002648:Child; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D006561:Herpes Simplex / Q000188:drug therapy*; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D007635:Keratitis, Dendritic / Q000188:drug therapy; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013283:Stomatitis, Herpetic / Q000188:drug therapy
D000998:Antiviral Agents; D006147:Guanine