Effects of imipramine treatment of separation-induced social disorders in rhesus monkeys.
Two groups of young rhesus monkeys were subjected to repetitive peer separations, a procedure that has been shown to produce depressivelike reactions in infant monkeys. Midway through the procedure one group was treated with the antidepressant imipramine hydrochloride, the other with a saline placebo. In comparison with placebo treatment, the imipramine treatment yielded significant behavioral improvement in a form and with a time course similar to that seen when the drug is given clinically to human depressives. We discuss the implications of the findings.
D000818:Animals; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D005260:Female; D000882:Haplorhini; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity; D010379:Peer Group; D010919:Placebos; D012919:Social Behavior; D012934:Social Isolation
D010919:Placebos; D007099:Imipramine