[Action of grisin on the variability of an Acinomyces griseus culture and the use of the same antibiotic as a selection agent in the selection of active variants].
The effect of grisin on survival and variation of Actinomyces griseus producin grisin was studied. The efficiency of various concentrations of grisin on induction of variation according to the feature of the antibiotic production was compared. A possibility of increasing the productivity of strain. VNIIGenetics-115 by the use of the mutations of resistance to grisin is shown.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D014644:Genetic Variation / Q000187:drug effects*; D012641:Selection, Genetic; D013305:Streptomyces griseus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013309:Streptothricins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013309:Streptothricins
Deĭstvie grizina na izmenchivost' kul'tury Actinomyces griseus i ispol'zovanie dannogo antibiotika v kachestve selektivnogo agenta pri otbore aktivnykh variantov.