Effect of specific antibodies on chronic echovirus type 5 encephalitis in a patient with hypogammaglobulinemia.
The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 x 10(4) units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1--4 x 10(4) units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient's CSF when the titer of antibody to echo 5 in CSF was greater than or equal to 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF.
D000361:Agammaglobulinemia / Q000150:complications*; D000914:Antibodies, Viral / Q000008:administration & dosage; D000918:Antibody Specificity; D001803:Blood Transfusion; D002675:Child, Preschool; D002908:Chronic Disease; D004660:Encephalitis / Q000150:complications / Q000276:immunology*; D029822:Enterovirus B, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007372:Interferons / Q000134:cerebrospinal fluid; D008297:Male; D010949:Plasma / Q000637:transplantation; D005719:gamma-Globulins / Q000627:therapeutic use
D000914:Antibodies, Viral; D005719:gamma-Globulins; D007372:Interferons