Conversion of 3H-testosterone to dihydrotestosterone in human hypertrophic prostatic tissue.
The aim of the study was to develop a simple method for the determination of the conversion of testosterone to 5 alpha-dihydrotestosterone (5 alpha-DHT) after incubation of human hypertrophic prostatic tissue with 3H-testosterone. The mean conversion rate of 3H-testosterone to 5 alpha-DHT in hypertrophic prostatic tissue was found to be higher than in normal and carcinomatous tissue. The results indicate that androgen metabolism in the hypertrophic prostatic gland is enhanced.
D000368:Aged; D013196:Dihydrotestosterone / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium
D013196:Dihydrotestosterone; D014316:Tritium; D013739:Testosterone