Transplacental effects of ethylnitrosourea in a nonhuman primate, Erythrocebus patas.
A breeding colony of the Old World monkey Erythrocebus patas, an African species, has been established to study transplacental carcinogensis in a representative primate species. ENU was administered by repeated iv injections to pregnant females and to juveniles of both sexes. Repeated doses of 0.1 mmole/kg body weight per injection, given at 14-day intervals, are tolerated without apparent signs of toxicity by fetal and by pregnant and nonpregnant adult or juvenile monkeys. The internal can be reduced to 7 days, at least during the latter two-thirds of pregnancy. Large single doses (1.0 mmole/kg) are tolerated by pregnant females but are frequently abortifacient. These doses produce acute cytolytic damage to the cells of the periventricular germinal matrix in the fetal brain. Studies with [14C]ethyl-ENU indicate that there is no placental barrier to this carcinogen. As of December 1975, no tumors had been observed.
D000818:Animals; D002273:Carcinogens; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000473:pathology; D004901:Erythrocebus patas; D005038:Ethylnitrosourea / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D000882:Haplorhini; D008431:Maternal-Fetal Exchange; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011247:Pregnancy; D014018:Tissue Distribution
D002273:Carcinogens; D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea