Prevention of neural tube malformation by genetic counselling, and prenatal diagnostic surveillance.
The aetiology and genetics of the spectrum of dysraphic neural tube malformations from anencephaly through encephalocele, myelocele and meningocele to complicated spina bifida occulta, is outlined. The risk of recurrence, the methods and problems of genetic counselling are discussed. All women known to be at risk for neural tube malformation should be counselled carefully and offered prenatal diagnostic surveillance for any future pregnancy. There is no longer any need for a couple able to accept termination, to go through with a pregnancy in fear of recurrence.
D000653:Amniotic Fluid / Q000032:analysis; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D009436:Neural Tube Defects / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012306:Risk; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins