title: Long-term acceptance of low-lactose milk.
abstract: Low-lactose milk was produced by incubating cow's milk with yeast lactase. Sixteen lactose tolerant and 15 intolerant volunteers ingested 500 ml of the product twice daily for 1 month. During the testing period all subjects received on three occasions the same volume of unmodified milk in double-blind tests. Symptoms recorded throughout the study and for an additional 15 day base-line observation period were: diarrhea, abdominal pain and distention, flatulence, heartburn, and headache. Low-lactose milk acceptance was excellent. No significant differences were found between tolerants and intolerants during the base-line period and while ingesting low-lactose milk. By contrast, unmodified milk induced severe symptoms only in the intolerants. Availability of low-lactose milk and of its by-products allows consumption of greater volumes of this highly nutritious food by subjects with lactose intolerance with none or less symptoms compared to unmodified milk.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D004311:Double-Blind Method; D006801:Humans; D007785:Lactose / Q000032:analysis; D007787:Lactose Intolerance / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008892:Milk / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism* / Q000592:standards; D001616:beta-Galactosidase
chemical_list: D001616:beta-Galactosidase; D007785:Lactose