Suppression of uterine motor activity by prostaglandin synthetase inhibitor Naproxen.
Rats were ovariectomized on day 16 of pregnancy and they were fitted with a pressure sensor uterine microballoon assembly and were given a daily dose of Naproxen-sodium. Daily uterine activity recordings were taken and subjected to statistical analysis and the rats were carefully checked for either aborting or delivering their fetuses. Our data showed that Naproxen treatment effectively and significantly prevented the autocatalytic evolution of the uterine motor activity and the regulatory "see-saw" of progesterone and prostaglandins was rebalanced at a lower level.
D000818:Animals; D002369:Castration; D016861:Cyclooxygenase Inhibitors; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects*; D009288:Naproxen / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D016861:Cyclooxygenase Inhibitors; D009288:Naproxen