In vivo and in vitro effects of gold salts on lymphocyte transformation responses and antibody dependent cell-mediated cytotoxicity.
In vivo, gold salts have been shown to induce disease remission in rheumatoid arthritis. In some patients, this is associated with a return to normal of suppressed lymphocyte responses to mitogens and antigens. This study demonstrates that gold salts will suppress lymphocyte transformation in vitro but do not affect antibody dependent cell-mediated cytotoxicity. This suppression appears to be dose-related. In contrast to previous studies, evidence is provided to suggest that the suppression of lymphocyte responses by gold may at least in part be due to a direct toxic effect of myochrisine on the cultured cells.
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology
D006052:Gold Sodium Thiomalate