[Disturbances of calcium-phosphate-metabolism by anticonvulsant drugs in relation to their serum concentration (author's transl)].
25.6% of 254 epileptic children receiving anticonvulsant drugs more than 3 years showed disturbances of Calcium-phosphate-metabolism and of ossification respectively. These disturbances are divided into 4 degrees of severity: 1. Raised alkaline phosphatase in serum alone 21 patients); 2. Metaphysial osteodystrophia (22 Pat.); 3. Generalised osteoporosis (16 Pat.) and 4. Vitamin-D sensitive rickets (6 Pat.). These abnormalities were found at most in long term-treatment with hydantoins or primidone. The measurement of serum concentration of these anticonvulsant drugs yielded significantly higher amounts in patients with abnormalities in Calcium-Phosphate-metabolism than in those patients without such ones. This result permits us to conclude that disturbances of Calcium-Phosphate-metabolism are serum-concentration-dependent side-effects of anticonvulsant drugs.
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects*; D008297:Male; D009999:Ossification, Heterotopic / Q000139:chemically induced*; D010024:Osteoporosis / Q000139:chemically induced; D010710:Phosphates / Q000378:metabolism*; D011324:Primidone / Q000009:adverse effects*; D012279:Rickets / Q000139:chemically induced
D006827:Hydantoins; D010710:Phosphates; D011324:Primidone; D000469:Alkaline Phosphatase; D002118:Calcium
Störungen des Kalzium-Phosphat-Stoffwechsels durch Antikonvulsiva in Relation zu ihrer Serumkonzentration.