[Model of meningococcal sepsis in mice].
The authors studied a possibility of obtaining experimental meningococcus sepsis model on mice. The use of cyclophosphane, iron compounds, yolk medium produced no significant organism. When 4--5% mucine was injected intraperitoneally together with meningococcus culture mice died with sepsis phenomena. Differences were revealed in the sensitivity of linear and mongrel mice to meningococcus infection--AKR mice proved to be more sensitive. At the same time it was found that mongrel mice weighing from 10 to 12 g could be used to induce meningococcus sepsis.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006824:Hybridization, Genetic; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009345:Neisseria meningitidis; D018805:Sepsis / Q000401:mortality; D013045:Species Specificity
Model' meningokokkovogo sepsisa na myshakh.