title: Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin.
abstract: Alcohol, ketone, aldehyde, and oxime analogues of ambruticin (1) were prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans, and Streptococcus pyogenes. Structure-activity relationships are described. Increasing the bulk of substituent at C1 and C5 reduces antifungal activity.
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000494:pharmacology; D000447:Aldehydes / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D009231:Myxococcales; D010091:Oximes / Q000138:chemical synthesis / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000935:Antifungal Agents; D007659:Ketones; D010091:Oximes; D011714:Pyrans; C014964:ambruticin