Secondary metabolic changes in fibroblasts from six patients with hereditary lactic acidosis.
Studies on fibroblasts from patients with lactic acidosis of different causes showed secondary metabolic changes in pathways of glucose metabolism. These secondary changes may be important clues to the diagnosis of the many different types of hereditary lactic acidosis.
D000138:Acidosis / Q000201:enzymology*; D002239:Carbohydrate Metabolism, Inborn Errors / Q000201:enzymology*; D002478:Cells, Cultured; D002675:Child, Preschool; D002952:Citric Acid Cycle; D005347:Fibroblasts / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007773:Lactates / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism
D007773:Lactates; D011773:Pyruvates; D005947:Glucose