The epidermal melanocyte system in patients with malignant melanoma. Quantitative and qualitative investigation of dopa positive melanocytes.
The results from this study indicate that in 5 out of 22 patients increased activity of the melanocytes in the vicinity (a few mm to 1 cm) of the tumour is to be found. In 8 out of 22 patients suspect cells were also found a few mm to 1 cm from the tumour; a finding which accounts for the frequent recurrence following close excision of the melanoma. Furthermore, it was ascertained that the total melanocyte population is increased in 14 out of 22 patients. An increased melanocyte population can contain a greater number of instabile cell forms that can easier be malignantly transformed under the influence of external factors.
D002452:Cell Count; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004295:Dihydroxyphenylalanine; D004817:Epidermis / Q000473:pathology; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000473:pathology*
D004295:Dihydroxyphenylalanine