Melanogenuria as consequence of elevated tyrosinase activity in melanoma.
The authors point out that melanogenuria, i.e. the excretion of specific phenolic and, particulary, indole metabolites in melanoma, is undoubtedly due to elevated tyrosinase activity in this disease. Other enzymes, in particular glucuronyltransferase, catechol-O-methyltransferase and possibly hydroxyindole-O-methyltransferase, also evidently participate in the further biochemical conversion of the resultant metabolites, however.
D000818:Animals; D004156:Catechol Oxidase / Q000378:metabolism*; D005134:Eye Neoplasms / Q000201:enzymology; D006801:Humans; D007211:Indoles / Q000652:urine*; D007700:Kinetics; D008543:Melanins / Q000652:urine*; D008545:Melanoma / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000201:enzymology; D014603:Uveal Diseases / Q000201:enzymology
D007211:Indoles; D008543:Melanins; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase