title: [Variation in delayed hypersensitivity to methylated bovine serum albumin as as function of the dose and time of administration of cyclophosphamide].
abstract: The injection of Cy before immunization provokes an intensification of delayed-type hypersensitivity (DTH) to methylated bovine serum albumin (M-BSA) and a diminution of about 90% of the cell number in various lymphoid tissues. The relationship between these observations, the time of administration, the dose of injected Cy and the intensity of DTH reactions, allows us to formulate hypotheses concerning the physiological modulation of DTH.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008745:Methylation; D051379:Mice; D012710:Serum Albumin, Bovine / Q000031:analogs & derivatives / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology; D013997:Time Factors
chemical_list: D012710:Serum Albumin, Bovine; D003520:Cyclophosphamide
vernacular_title: Variation de l'hypersensibilité retardée à la sérum albumine bovine méthylée en fonction de la dose de cyclophosphamide et du moment de son administration.