Insulin counteraction of alpha-adrenergic effects on liver glycogen metabolism.
Insulin counteracted the effects of a pure alpha-adrenergic agonist, phenylephrine, on hepatocyte glycogen synthase and phosphorylase. These results argue against current concepts of insulin increasing cytoplasmic Ca2+ concentration.
D000818:Animals; D006006:Glycogen Synthase / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D010656:Phenylephrine / Q000037:antagonists & inhibitors*; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats
D007328:Insulin; D008112:Liver Glycogen; D010656:Phenylephrine; D006005:Phosphorylases; D006006:Glycogen Synthase