[Reactogenicity and immunological effectiveness study of a complex paratyphoid B antigen].
Reactogenic property and immunological efficacy of the paratyphoid preparation containing a complex of O-, K- and H-antigens obtained by single-stage antigens extraction were studied in a limited group of volunteers (22 persons). The antigen gave no untoward reactions and proved to be safe when given orally in doses of 25 to 150 mg. Paratyphoid B antigen was characterized by a marked immunization activity and stimulated formation of specific paratyphoid O-, K- and H-agglutinins and antibodies of the IgA,- IgG,- and IgM-classes.
D000373:Agglutinins / Q000032:analysis; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis*; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002986:Clinical Trials as Topic; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D010284:Paratyphoid Fever / Q000517:prevention & control*; D011817:Rabbits; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000276:immunology
D000373:Agglutinins; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014436:Typhoid-Paratyphoid Vaccines
Izuchenie reaktogennosti i immunologicheskoĭ éffektivnosti kompleksnogo paratifoznogo B antigena.