title: Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment.
abstract: Zebu cattle infected with either Trypanosoma congolense EATRO 1800 or Trypanosoma vivax EATRO 1721 had suppressed humoral immune responses to Leptospira biflexa injected intravenously and to attenuated Brucella abortus injected subcutaneously. T. congolense infections were more suppressive than T. vivax infections. In cattle infected with T. vivax, the suppression of immune responses to both bacterial immunogens was abrogated when the animals were treated with Berenil at the time of antigen administration. In cattle infected with T. congolense, simultaneous Berenil treatment at the time of vaccination abolished the suppression of immune response to L. biflexa, and lessened but did not abrogate the suppression of immune response to B. abortus.
mesh_terms: D000578:Amidines / Q000627:therapeutic use*; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002003:Brucella abortus / Q000276:immunology*; D002417:Cattle; D004133:Diminazene / Q000627:therapeutic use*; D007114:Immunization; D007919:Leptospira / Q000276:immunology*; D008297:Male; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014354:Trypanosomiasis, Bovine / Q000276:immunology*
chemical_list: D000578:Amidines; D000907:Antibodies, Bacterial; D014344:Trypanocidal Agents; D004133:Diminazene