The effect of propranolol phentolamine and pimozide on drug-induced anorexia in the mouse.
Pimozide was a potent antagonist of (+)amphetamine, diethylpropion, mazindol and phentermine anorexia in the mouse. Phentolamine and propranolol produced no such antagonism, but either potentiated or had no effect on the drug-induced anorexia. Although the mechanism of action of the four anorectic agents appears to involve dopamine receptor agonist activity, an antagonist or partial agonist effect at noradrenergic receptors may also be involved.
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004053:Diethylpropion / Q000494:pharmacology; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D008454:Mazindol / Q000494:pharmacology; D051379:Mice; D010645:Phentermine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology*; D010868:Pimozide / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D001067:Appetite Depressants; D010868:Pimozide; D011433:Propranolol; D010645:Phentermine; D008454:Mazindol; D004053:Diethylpropion; D003913:Dextroamphetamine; D010646:Phentolamine