Electroencephalographic and behavioral effects of a GABA agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio.
Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, Papio papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 hr after muscimol injection. Regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1-3 hr after muscimol. Photically induced myoclonus was not modified by muscimol. Despite its GABA-abonist properties, muscimol is not an effective anticonvulsant.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D000882:Haplorhini; D009118:Muscimol / Q000627:therapeutic use*; D010080:Oxazoles / Q000627:therapeutic use*; D010215:Papio; D010775:Photic Stimulation; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D010080:Oxazoles; D009118:Muscimol