Presensitization of potential kidney recipients detected by cell kinetic studies in the pooled mixed lymphocyte reaction.
An accelerated response in the pooled mixed lymphocyte reaction (PMLR) and/or the existence of cytotoxic antibodies indicates presensitization of potential kidney recipients. The absence of cytotoxic antibodies does not exclude presensitization, which can be demonstrated by a premature response in the PMLR. However, transfusions may also lead to impaired proliferation. In some patients, blood transfusions induce blocking activities. The possible mechanisms of this phenomenon are discussed. Measuring the immune response by cell kinetic studies with the PMLR gives further information on the immune state of potential kidney recipients.
D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D016030:Kidney Transplantation; D007700:Kinetics; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous