Dehydroepiandrosterone and dehydroepiandrosterone sulfate dynamics in obesity.
Dehydroepiandrosterone (D) and dehydroepiandrosterone sulfate (DS) dynamics were studied in three obese female subjects following a single injection of [4-14-CA1D and [7 alpha-3-H]-DS tracers. Dynamic parameters were calculated simultaneously by both the urinary and blood method of compartmentalization; Estimates for the urinary secretion and production rates of D were found to be high, and those of DS varied within normal range. Calculation of the conversion factors, rho DDS and rho DSD, by the urinary method revealed a noraml extraglandular DS yields D conversion, while that for D yields DS appeared deficient in obese female subjects. Estimates of inner and outer pool distribution volumes were extremely increased for free D; in contrast to this, moderately increased inner and decreased outer pool volumes of DS were observed. The metabolic clearance rates of D were normal or decreased and those for DS were greater than normal. The blood production rates of both B and DS were higher in obese female subjects than those estimated for normal women in our previous study; These observations suggest a considerable uptake of unconjugated D by adipose tissue, an overall poor D yields DS conversion and an accelerated DS metabolism in obese female subjects.
D000328:Adult; D001827:Body Height; D001835:Body Weight; D002250:Carbon Radioisotopes; D003687:Dehydroepiandrosterone / Q000097:blood / Q000378:metabolism*; D005260:Female; D005965:Glucuronates / Q000652:urine; D006801:Humans; D007553:Isotope Labeling; D009765:Obesity / Q000378:metabolism*; D013464:Sulfuric Acids / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
D002250:Carbon Radioisotopes; D005965:Glucuronates; D013464:Sulfuric Acids; D014316:Tritium; D003687:Dehydroepiandrosterone