Effect of some antirheumatics on connective tissue components.
The effects of a number of classical and modern antirheumatics on the biosynthesis of glycosaminoglycans and collagen were studied comparatively. The experimental results indicate that the antirheumatics deeply affect the metabolism of the main components of connective tissue. With regard to the methods used for testing, it may be stated that phenylbutazone, flufenamic acid, ibuprofen, mefenamic acid and trimetazone belong to the most effective of the entire series of antirheumatics tested.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002417:Cattle; D003094:Collagen / Q000096:biosynthesis*; D005944:Glucosamine / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D013431:Sulfates / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans; D013431:Sulfates; D003094:Collagen; D005944:Glucosamine