title: High-dose tetracycline therapy in severe acne.
abstract: High daily doses of tetracycline (in most instances 2,000 mg) were administered over periods of 3 to 33 months to 31 patients suffering from unusually severe, disfiguring, and treatment-resistant forms of acne (papulopustular, cystic, and conglobated). The acne cleared in 14 patients, improved greatly in 13, improved only insignificantly in 3, and failed to improve in 1. Side-effects occurred in 15 of the 31 patients but necessitated cessation of treatment in only three.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D012867:Skin / Q000032:analysis; D013754:Tetracyclines / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D005230:Fatty Acids, Nonesterified; D013754:Tetracyclines