title: [Which antibiotics are helpful in acne? A review of the literature and personal test results with minocyclin (klinomycin)].
abstract: All tetracycline preparations seem to be systemically effective in acne. Quality and frequency of their side-effects, however, are different and should be carefully considered in each individual case. In an own study ninety-one patients treated with minocycline showed good response in 69% and moderate or no response in 31+. The main side-effects of the drug were nausea and giddiness, being of short duration in most cases. In patients with no response to a certain preparation change of the preparation may be helpful. Occasionally, acne does not respond to any tetracycline derivative. In these cases the use of non-tetracycline antibiotics, particularly of trimethoprim-sulphamethazol and lincomycines, is clearly effective. As a rule, we start treatment with tetracycline (500-750 mg/d) and reduce the dose to a minimum (ca. 100 mg/d), in order to withdraw the drug. In non-responsive cases another derivative and/or finally non-tetracycline antibiotics are administered for therapy.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008911:Minocycline / Q000009:adverse effects / Q000627:therapeutic use*; D013754:Tetracyclines / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D008911:Minocycline
vernacular_title: Welche Antibiotika helfen bei Akne? Eine Ubersicht der Literatur und eigene Prüfungsergebnisse mit Minocyclin (Klinomycin)