[Effect of p-chlorophenylalanine on the reproduction of the rat (author's transl)].
The effect of p-chlorophenylalanie (p-CPA) --300 mg/kg-- on reproduction has been studied in the female rat. Groups of animals were injected with a dose of 300 mg/kg of p-CPA 48 hours before proper copulation conditions at different moments along the ovarian cycle. Presence of spermatozoa in the vaginal frotis was negative in treated rats; in the control groups however, positivity was found in variable proportions according to the phase of the ovarian cycle: 30 ad 90% in diestrus and proestrus respectively. Treated animals showed continuous diestrus phases and diffuse luteinitation of the ovary. The results may indicate that a decrease of cerebral 5-HT, caused by p-CPA, lessens the reproductive behaviour of the female rat through mechanisms depending probably on the liberation of gonadrotrophins.
D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D010134:Fenclonine / Q000494:pharmacology*; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D010053:Ovary / Q000502:physiology*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism
D006065:Gonadotropins, Pituitary; D012701:Serotonin; D010134:Fenclonine
Efecto de la p-clorofenilalanina sobre la reproducción en la rata