On the possible involvement of sulphomucopolysaccharides in the storage of catecholamines within the central nervous system.
Rats treated at birth with 6-OH DA were sacrificed in adult age 24 h after an injection of 3H-NA. Synaptosomes were isolated from the cerebral cortex, the hypothalamus, the pons-medulla region and the cerebellum. The similar distribution pattern of 3H-NA and 35S on gradient centrifugation of the synaptosome preparations, the similar effect of 6-OHDA on the uptake of 3H-NA into slices of brain tissue in vitro and on their 35S content as well as the identification of chondroitin and heparan sulphate in the synaptosome fractions are observations which indicate a possible function of SMPSs in the storage of NA in adrenergic terminals.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003714:Denervation; D006025:Glycosaminoglycans / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D009411:Nerve Endings / Q000378:metabolism; D011149:Pons / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism
D002395:Catecholamines; D006025:Glycosaminoglycans; D006892:Hydroxydopamines