The role of serotonin in ephedrine-induced stereotypy and hypermotility.
The influence of serotonin agents on stereotypy and hypermotility induced with ephedrine was studied. P-Chlorophenylalanine (PCPA), an inhibitor of serotonin synthesis, had no influence on stereotypy. In reserpinized animals, this reaction was intensified only after high doses of ephedrine (100 and 120 mg/kg), but the precursor of 5-HT synthesis, tryptophan, strongly antagonized stereotypy. Ephedrine-induced hypermotility in mice and rats was potentiated by PCPA. It is suggested that serotonin ephedrine-induced effects, similarly to previous observations with amphetamine.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D004347:Drug Interactions; D004809:Ephedrine / Q000494:pharmacology*; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D014364:Tryptophan / Q000494:pharmacology
D012701:Serotonin; D012110:Reserpine; D014364:Tryptophan; D004809:Ephedrine; D010134:Fenclonine