[Active enhancement of canine kidney allografts (author's transl)].
In 32 beagles heterotopic renal allotransplantations and bilateral nephrectomies were carried out. Control animals (5 dogs) survived 9.4 +/- 1.6 days. 22 recipients were pretreated with donor-specific semisoluble spleen antigen; 5 recipients pretreated with the antigen alone (780 mg/kg body weight) survived 16.6 +/- 2.3 days. A pretreatment with antigen combined with 5 mg/kg body weight Prednisolone resulted in no significant prolongation of survival time (5 animals), but 5 dogs survived significantly longer after pretreatment with the antigen and 50 mg/kg body weight Prednisolone (27.4 +/- 2,7 days). In 5 recipients after preoperative application of 3 doses Prednisolone alone (50 mg/kg body weight each) no prolongation of survival time could be observed (10.2 +/- 0.7 days). We found no correlation between lymphocytotoxic antibody titre and survival time.
D000818:Animals; D000941:Antigens; D003601:Cytotoxicity Tests, Immunologic; D004285:Dogs; D006084:Graft Rejection; D016030:Kidney Transplantation; D011239:Prednisolone / Q000627:therapeutic use; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
D000941:Antigens; D011239:Prednisolone
Aktives Enhancement von Hundenierenallotransplantaten