[Action of prostaglandin F2 alpha on pregnancy in mice. Prevention of its abortive property by progesterone].
Prostaglandin F2alpha determines a high proportion of abortions in the mouse when administered before implantation at a dose level of 2 mg/kg. After implantation between days 6-8 or 7-9, doses 20 times higher are necessary to produce the effect. Daily progesterone administration, 5 mg per animal, from day 1 to day 17 allow the evolution of pregnancy in 60% of the mice even when 120 mg/kg prostaglandin is given. This dose determines usually 100% abortions. No teratogenic effect has been observed.
D000022:Abortion, Spontaneous / Q000139:chemically induced*; D000818:Animals; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology*; D011460:Prostaglandins F; D013997:Time Factors
D011460:Prostaglandins F; D011374:Progesterone
Action de la prostaglandine F2alpha sur la gestation de la Souris. Prévention du pouvoir abortif par la progestérone