title: [Measurement of renal blood flow with the Anger scintillation camera after selective intra-arterial injections of 133xenon and 99mtechnetium].
abstract: A "region of interest" technique for measuring renal blood flow is described, using as Anger camera and selective intra-arterial injection of 133Xe and 99mTc. The sequence of measurements has the advantage of providing information on regional blood flow. The values for RBF and RBFD obtained with 133Xe agree with those in the literature. Selective determination of the RCBF with the "region of interest" technique using 133Xe was not possible. Mean transit time for 99mTc was calculated after correction of the 99mTc indicator dilution curve with respect to recirculation and background activity. All typer of pathological changes in the kidney showed a statistically significant increase in mean transit time when compared with a control group. In patients with uncomplicated essential hypertension, the mean transit time was signigicantly reduced. A comparison of the mean transit time of 99mTc with the haemodynamic parameters derived from the 133Xe studies, and experiments with pharmocologically induced vasoconstriction indicates that the mean transit time represents a measure of the RCBF.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007668:Kidney / Q000098:blood supply*; D007674:Kidney Diseases / Q000175:diagnosis / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D011868:Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods*; D012039:Regional Blood Flow / Q000187:drug effects; D013667:Technetium / Q000008:administration & dosage; D013997:Time Factors; D014978:Xenon / Q000008:administration & dosage
chemical_list: D011868:Radioisotopes; D014978:Xenon; D013667:Technetium; D009638:Norepinephrine
vernacular_title: Die Messung der Nierendurchblutung mit der Anger-Szintillationskamera nach selektiver intraarterieller Injektion von 133-Xenon und 99m-Technetium