title: [Parameters of the toxic action of antibiotic derivatives of aureolic acid in acute and subchronic experiments].
abstract: The parameters of the lethal effect of aureolic acid derivatives, such as mithramycin, variamycin and olivomycin were studied on mice, rats and rabbits. As for the most of the administration routes the first two drugs were characterized by irregular distribution of resistance to thier lethal effect, which was mathematically expressed by polymodality of the dose-response curve. The above drugs were characterized by cumulative properties. The toxicity parameters depended on the animal species and administration route.
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D007928:Lethal Dose 50; D051379:Mice; D009848:Olivomycins / Q000008:administration & dosage / Q000633:toxicity*; D008926:Plicamycin / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D009848:Olivomycins; D008926:Plicamycin
vernacular_title: Parametry toksicheskogo deĭstviia antibiotikor--proizvodnykh aureolovoĭ kisloty v ostrom i subkhronicheskom opytakh