Evidence that the deferential vein acts as a local transport system for androgen in the rat and the dog.
Ligation of the deferential vein of the rat has been shown to bring about a reduction in the androgen-dependent activity of the prostatic RNA polymerase enzyme. In the dog, the content of androgens in this vein is of the order of that found in the testicular vein and many times higher than that of peripheral plasma. It seems that the cauda epididymidis alone is sufficient to maintain the ipsilateral lobes of the prostate and seminal vesicles providing an intact ductus deferens and contralateral testis are retained. The results are discussed in relation to the hypothesis that the deferential vein of the dog and rat may serve as a direct transporting system for androgens from the epididymis to the prostatic complex.
D000731:Androstanes / Q000032:analysis; D000735:Androstenedione / Q000032:analysis; D000738:Androsterone / Q000032:analysis; D000818:Animals; D001692:Biological Transport; D002369:Castration; D004247:DNA / Q000032:analysis; D012321:DNA-Directed RNA Polymerases / Q000032:analysis; D003687:Dehydroepiandrosterone / Q000032:analysis; D013196:Dihydrotestosterone / Q000032:analysis; D004285:Dogs; D004822:Epididymis / Q000601:surgery; D008026:Ligation; D008297:Male; D011467:Prostate / Q000032:analysis / Q000378:metabolism; D012313:RNA / Q000032:analysis; D051381:Rats; D012669:Seminal Vesicles / Q000032:analysis; D013739:Testosterone / Q000032:analysis / Q000097:blood*; D014649:Vas Deferens / Q000098:blood supply*; D014659:Vasectomy; D014680:Veins
D000731:Androstanes; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D012313:RNA; D004247:DNA; D000738:Androsterone; D012321:DNA-Directed RNA Polymerases