Lymphocyte transformation induced by human granulocytes.
Contrary to previous reports, human granulocytes are capable of causing transformation of allogeneic lymphocytes. Pretreatment of granulocytes with mitomycin C results in nonstimulation, but untreated granulocytes are capable of stimulating lymphocytes. Nonstimulation with mitomycin C-treated granulocytes may result from the reduced viability of the cells. It is concluded that granulocytes possess alloantigens that stimulate lymphocytes in vitro.
D002452:Cell Count; D002458:Cell Fractionation; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008937:Mitomycins / Q000494:pharmacology
D008937:Mitomycins