Effect of clofibrate on plasma proteins including components of the hemostatic mechanism.
The effect of clofibrate (1.5 g/day) on different plasma proteins and on components of the hemostatic system was studied in eight men with either mild diabetes mellitus or cardiosclerosis. Before treatment, the subjects were investigated weekly on five occasions. The means of these determinations were compared with the values observed after 2, 6 and 14 weeks of treatment. During the treatment albumin and transferrin increased significantly while orosomucoid, ceruloplasmin, beta1 E-globulin, IgA, IgM and fibrinogen decreased significantly. The decreases of the last proteins in per cent were found to be associated with each other in single subjects, i.e. a subject who reacted with a certain degree of change in one protein tended to react in a similar way with regard to the other proteins. A correlation was observed between the concentration before the treatment and the decrease in concentration during the treatment for ceruloplasmin, IgG, IgA, IgM and fibrinogen. The fibrinolytic activity increased significantly. Plasminogen decreased after 6 weeks and increased after 14 weeks of treatment. Platelet adhesiveness was not influenced.
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology; D001798:Blood Proteins / Q000502:physiology*; D002994:Clofibrate / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology; D005341:Fibrinolysin / Q000502:physiology; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology; D010973:Platelet Adhesiveness / Q000187:drug effects
D001798:Blood Proteins; D005341:Fibrinolysin; D002994:Clofibrate