[Physiopathogenesis of idiopathic hairy virilism. II. Sources and mechanisms of the increase of production of androgens in idiopathic hairy virilism].
The rise in the secretion of androgens appears in many cases (50 per cent of cases) of primary idiopathic hairy virilism to be mixed or exclusively ovarian which in turn excludes the adrenal (less than 10 per cent of cases) in the production of androstenedione and testosterone. The part that the adrenals play in hyperandrogenization seems to be the result of enzymic partial blocks which are more or less compensated for. Thus about half of cases of idiopathic hairy virilism are of mixed origin, although the role of the ovary is by and large predominant for testosterone, whether the ovaries are or are not macroscopically polycystic. Both overproduction of androgens and/or overproduction of oestrogens by the ovaries can be responsible for overfunctioning of the adrenals in an androgenic manner because of enzymic dysfunction. In some cases the reverse can be demonstrated but then the functional pathology is more obscure.
D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005260:Female; D006801:Humans; D013739:Testosterone / Q000096:biosynthesis* / Q000378:metabolism; D014770:Virilism / Q000378:metabolism*
D000728:Androgens; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone
Physiopathogénie du "virilisme pilaire idiopathique" II.--Sources et mécanismes de l'augmentation de la production androgénique dans le virilisme pilaire idiopathique.