Immunomorphological reactivity of the intrapulmonary lymphoid tissue.
Young albino rats were repeatedly stimulated by a pulverized suspension of living pneumococci and others by intramuscular injection of killed microbes emulsified in complete Freund adjuvant. The bronchus associated lymphoid nodules increase in size and number; the proximal nodules contain one more follicle with germinal centers formed of pyroninophilic lymphoblasts and plasma cells at the periphery. The follicular organization and the pyronine - plasma cells differentiation point out the ability of these nodules to elaborate a local immune response to antigenic stimulation.
D000818:Animals; D000942:Antigens, Bacterial; D001980:Bronchi / Q000276:immunology; D005620:Freund's Adjuvant / Q000008:administration & dosage; D008168:Lung / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D010950:Plasma Cells; D051381:Rats
D000942:Antigens, Bacterial; D005620:Freund's Adjuvant