[Effect of theophylline on diuresis and the physiological proteinuria of white rats].
The present study considers the quantitative variations of the physiologic proteinuria with theophyllin in the rat. The urins are collected, during 8 hours, every Rat being its own reference. The single theophyllin injection (20 mg/kg) induces an increased diuresis (+ 42,1 %) and proteinuria (+ 73,7 %). The repetitive theophyllin injections (during 5 days) confirms this constation. The hypothesis of a modification of the permeability of the glomerular barrier to proteic macromolecules is proposed to agree this result.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D008297:Male; D011507:Proteinuria / Q000139:chemically induced*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors
D013806:Theophylline
Influence de la théophylline sur la diurèse et la protéinurie physiologique de rat blanc.