title: Formiminoglutamate excretion in rat urine after whole body irradiation, histidine administration, starvation and stress.
abstract: Formiminoglutamate (FIGLU) urinary excretion was studied in rats subjected to whole body 60Co irradiation with doses of 450, 650 and 850 R. During the first post-irradiation days, FIGLU excretion doubled after both lower doses. From day 3, 450 R led to a decrease, whereas 650 and 850 R were followed by a still enhanced FIGLU excretion. No correlation to the radiation dose was found. A daily intraperitoneal administration of histidine in a dose of 200 mg/kg led to a constant 5-fold increase of FIGLU output and to more distinct differences in post-irradiation FIGLU excretion. Two days starvation or ACTH administration, followed by doubled urinary total 17-hydroxycorticoids, did not interfere with FIGLU excretion.
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes; D005565:Formiminoglutamic Acid / Q000652:urine*; D005977:Glutarates / Q000652:urine*; D006639:Histidine / Q000494:pharmacology*; D008297:Male; D011832:Radiation Injuries / Q000652:urine*; D051381:Rats; D013217:Starvation / Q000652:urine*; D013312:Stress, Physiological / Q000652:urine*
chemical_list: D003037:Cobalt Radioisotopes; D005977:Glutarates; D006639:Histidine; D005565:Formiminoglutamic Acid