title: [Radiation-induced aggregation of proteins: binding of amino acids to myoglobin (author's transl)].
abstract: When myoglobin is irradiated in the presence of amino acids, the most radiation-reactive species, like the aromatic and sulfur-containing amino acids, will bind preferentially to the protein. The radiation-induced binding is strongly dependent on the concentration of protein and amino acid. Subsequent to irradiation of myoglobin in the presence of radioactively labelled tryptophan followed by tryptic hydrolysis, only a single radioactive spot was detected on the fingerprint. The binding of amino acids is thus not randomly distributed over the protein molecule but occurs at specific reactive sites.
mesh_terms: D000596:Amino Acids / Q000528:radiation effects*; D000818:Animals; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D009211:Myoglobin / Q000528:radiation effects*; D011485:Protein Binding / Q000528:radiation effects; D014907:Whales
chemical_list: D000596:Amino Acids; D003037:Cobalt Radioisotopes; D009211:Myoglobin
vernacular_title: Strahleninduzierte Aggregatbildung von Proteinen: Bindung von Aminosäuren an Myoglobin.