title: [Systemic changes in occupational vitiligo].
abstract: In three patients with occupational vitiligo caused by paratertiary butylphenol--the first cases observed in the BRD--a functional disorder of the liver was found. In two of these patients splenomegaly was seen. The laboratory findings, the laparoscopic examination and the result of the liver-biopsy are described. It is assumed that these changes as well as the depigmentation and a functional disorder of the thyroid (described elsewhere) are caused by the systemic action of inhaled paratertiary butylphenol.
mesh_terms: D000328:Adult; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000175:diagnosis; D004781:Environmental Exposure; D006801:Humans; D010535:Laparoscopy; D008099:Liver / Q000473:pathology; D008297:Male; D010636:Phenols / Q000009:adverse effects; D013163:Splenomegaly / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis; D014820:Vitiligo / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D010636:Phenols
vernacular_title: Systemische Veränderungen bei berufsbedingter Vitiligo