Segregation of HL-A27 and ankylosing spondylitis in an informative kindred.
A family with high prevalence of ankylosing spondylitis (A.S.) was investigated for the presence of HL-A27. In this family, classical A.S. occurred in five subjects and possible A.S. in two out of 64 members examined. In all seven cases, HL-A27 was present. The study of the segregation of A.S. and HL-A27 in this kindred demonstrates that more than one gene is responsible for the expression of A.S., that the homozygous state for the HL-A27 gene may lead to the occurrence of A.S., and that possibly a simple genetic explanation accounts for the simultaneous transmission of HL-A27 and A.S.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011995:Recombination, Genetic; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens