Androgen-dependent fibrinolytic activity in a murine mammary carcinoma (Shionogi SC-115 cells) in vitro.
Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of estrogen. Furthermore, an autonomous tumor derived from the Shionogi SC-115 cells produced fibrinolytic activity independent of added DHT or estrogen. These observations suggest a close correlation between fibrinolytic activity of a tumor and its ability to grow in vivo.
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D005341:Fibrinolysin / Q000378:metabolism*; D005342:Fibrinolysis / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology; D007531:Isoflurophate / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D014361:Trypsin Inhibitors / Q000494:pharmacology
D000614:Aminocaproates; D001565:Benzoates; D004967:Estrogens; D006146:Guanidines; D014361:Trypsin Inhibitors; D013196:Dihydrotestosterone; D007531:Isoflurophate; D005341:Fibrinolysin