[Endogenous hyperlactatemia and insulin secretion].
In the normal anesthetized dog, the endogenous hyperlactatemia induced either by intense muscular work or by a high dose of phenformin (20 mg/kg subtucaneously) is followed by an increase in the pancreaticoduodenal insulin output. A previous perfusion of sodium dichloroacetate (50 mg/kg. h) opposes the hyperlactatemia, and reduces or suppresses the increase in insulin output.
D000818:Animals; D003999:Dichloroacetic Acid / Q000494:pharmacology; D004285:Dogs; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D007773:Lactates / Q000097:blood*; D010629:Phenformin / Q000494:pharmacology; D005082:Physical Exertion
D007328:Insulin; D007773:Lactates; D003999:Dichloroacetic Acid; D010629:Phenformin
Hyperlactatémies endogènes et insulino-sécrétion.