Cellular- and permeability-changes in the peritoneal cavity of mice after injection of endotoxon.
Injection of endotoxin into the peritoneal cavity of mice causes an early emigration of PMN-leucocytes and therafter a decrease in macrophage count. The number of lymphocytes shows only a transient increase. One and 2 injections of endotoxin rise the fibrinogen and protein level of the peritoneal fluid. A simple test for measuring the change in permeability (and lymph circulation) was described ("congo red elimination's test"). Changes in permeability occur after a latent period of 2 hours following endotoxin administration, culminate during the 1st day and last about 3-4 days. The possible mechanisms of the above phenomena are discussed.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003224:Congo Red; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D005340:Fibrinogen / Q000032:analysis; D051379:Mice; D010529:Peritoneal Cavity / Q000276:immunology*; D011506:Proteins / Q000032:analysis
D004731:Endotoxins; D011506:Proteins; D003224:Congo Red; D005340:Fibrinogen