[Temporary normalization of blood sugar, in a totally pancreatectomized dog, after placing an artificial insulin distributor].
Islets of Langerhans were stablished in the spaces between 9 synthetic hollowfibers in a "bio-artificial insulin distributor" which was implanted in the carotid artery of totally pancreatectomized dogs. Normo-glycemia was restored after 4 hours. The major problem encountered was coagulation in the fibers. Presently, this limits the prolonged utilization of this system.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000628:therapy*; D004285:Dogs; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation; D008722:Methods; D010180:Pancreatectomy; D014184:Transplantation, Homologous
D001786:Blood Glucose; D007328:Insulin
Normalisation glycémique temporaire, chez le chien totalement dépancréaté, après mise en place d'un distributeur bioartificiel d'insuline.