Genetically controlled autologous immune complex glomerulonephritis in rats.
A study was conducted on the disease susceptibility of inbred strains of rats to experimental autologous immune complex glomerulonephritis (AIC). Three strains representing two different H-1-haploytpes developed severe glomerulonephritis within 3 months in response to a single injection with equal doses of an autologous primary tubular epithelial fraction and complete Freund's adjuvant (Lewis, AS (H-11)) and Lew.BDV (H-1d)).By contrast, two strains of the H-1 haplotype H-1n (BN and Lew.BN) showed no proteinuria and no immunohistologic findings during that time. Hybrids of Lew.BN and Lewis, subjected to the same immunizing procedure, showed a later onset of the disease as compared to the responder parent. The possible relationship between responder status and the major histocampatibility complex is discussed.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D005796:Genes; D005921:Glomerulonephritis / Q000276:immunology*; D007105:Immune Complex Diseases / Q000276:immunology*; D007114:Immunization; D007271:Injections, Intradermal; D007678:Kidney Glomerulus / Q000032:analysis; D007684:Kidney Tubules / Q000276:immunology; D008297:Male; D009393:Nephritis / Q000276:immunology; D011507:Proteinuria / Q000276:immunology; D051381:Rats; D011914:Rats, Inbred BN / Q000276:immunology*; D011917:Rats, Inbred Lew / Q000276:immunology*; D011919:Rats, Inbred Strains / Q000276:immunology*
D000941:Antigens