[The acquisition of antibody diversity studied in anuran amphibians (author's transl)].
For T and B lymphocytes, the capacity of recognizing diverse antigens is acquired early in ontogeny. This is shown for T cells by graft rejection and mixed leucocyte reaction experiments and for B cells by the heterogeneity of antibody response in young larvae which only possess a small number of lymphocytes. Thus any proposed mechanism for the generation of antibody diversity in frogs has to take into account: (a) that such diversity is acquired within about 21-30 days after fertilization in larvae whose lymphocyte generation time is 36-40 h; (b) that genetically identical animals have similar immune responses as revealed by mixed leucocyte reaction for T cell responses and by isoelectric focussing patterns for anti-dinitrophenyl and anti-sheep red blood cells antibodies for B cells.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000918:Antibody Specificity; D004626:Embryology; D004912:Erythrocytes / Q000276:immunology; D006579:Heterozygote; D007125:Immunogenetics; D007074:Immunoglobulin G / Q000032:analysis; D007814:Larva / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D009578:Nitrobenzenes / Q000276:immunology; D013045:Species Specificity; D014981:Xenopus
D000906:Antibodies; D007074:Immunoglobulin G; D009578:Nitrobenzenes
L'acquisition de la diversité des anticorps étudiée chez les amphibiens anoures