[Streptozotocin diabetes in a miniature pig (author's transl)].
The intravenous application of 60 mg streptozotocin/kg body weight to a Hanford miniature pig 8 days after a first dose of 30 mg/kg led to a diabetes with loss of insulin response to glucose, hyperglycaemia, glucosuria and a considerable increase of triglycerides and cholesterol. The application of 40 mg streptozotocin/kg to a second pig had no effect.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000139:chemically induced*; D005260:Female; D006029:Glycosuria / Q000139:chemically induced; D006943:Hyperglycemia / Q000139:chemically induced; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood; D008297:Male; D011863:Radioimmunoassay; D013045:Species Specificity; D013311:Streptozocin / Q000008:administration & dosage / Q000009:adverse effects*; D013552:Swine; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol
Streptozotocindiabetes beim miniaturschwein