Chemotherapy studies in autochthonous rat tumors intestinal cancer.
Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N'-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D004127:Dimethylhydrazines; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008769:Methylnitronitrosoguanidine; D051381:Rats
D004127:Dimethylhydrazines; D008769:Methylnitronitrosoguanidine; D004317:Doxorubicin; D003520:Cyclophosphamide; D004128:Dimethylnitrosamine; D005472:Fluorouracil; D008727:Methotrexate