[Comparison of the effectiveness of antivertiginous drugs by double blind procedure. The effect of diazepam, dimenhydrinate and sulpirid on the human vestibular spontaneous nystagmus (author's transl)].
The effect of Diazepam (Valium), Dimenhydrinate (Vomex A, Novomina, Epha Retard), Sulpirid (Dogmatil) and Placebo has been investigated in regard to the intensity of pathological vestibular spontaneous nystagmus by application of the double blind method on 50 patients with peripheral vestibular (n = 37) and central vestibular (n = 12) diseases, as well as on a case of spontaneous nystagmus of undefined origin. Since by acute vestibular disease the intensity of spontaneous nystagmus is generally closely related to the severity of vertigo, the influence on a pathological spontaneous nystagmus by antivertiginosa seems to be a dependable criterium in the evaluation of their effectiveness. Dimenhydrinate (2 mg/kg KG) and Sulpirid (2.86 mg/kg KG) led to a statistically significant reduction, however not in the case of Diazepam and Placebo. Nevertheless, the effectiveness of Dimenhydrinate and Sulpirid is not definitely predictable in individual cases: in 2 out of 10 patients the preparations were without effect. Characteristics and areas of indication of Dimenhydrinate and Sulpirid are described in greater detail.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D004111:Dimenhydrinate / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000188:drug therapy*; D013469:Sulpiride / Q000008:administration & dosage / Q000627:therapeutic use*; D014717:Vertigo / Q000188:drug therapy
D013469:Sulpiride; D004111:Dimenhydrinate; D003975:Diazepam
Wirkungsvergleich von Antivertiginosa im Doppelblindverfahren. Zum Einfluss von Diazepam, Dimenhydrinat und Sulpirid auf den vestibulären Spontannystagmus des Menschen