title: Chymopapain chemonucleolysis in lumbar disk disease.
abstract: Experience with chymopapain chemonucleolysis in 1,200 cases of lumbar disk disease indicates that it is an effective method of relieving pain resulting from an abnormal intervertebral disk. Complications were few; anaphylaxis occurring immediately after injection was by far the most serious. With the use of a corticosteroid and an antihistamine in preoperative preparation, the incidence of anaphylaxis had dropped, although it still occurs. On long-term follow-up, chemonucleolysis appears to be as good as laminectomy in properly selected cases.
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D001416:Back Pain / Q000188:drug therapy; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005500:Follow-Up Studies; D006801:Humans; D007278:Injections, Spinal; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000187:drug effects*; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009192:Myelography; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits; D012585:Sciatica / Q000188:drug therapy; D013997:Time Factors
chemical_list: D010447:Peptide Hydrolases