24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate.
Dehydroisoandrosterone (DHA) and cortisol were measured by radioimmunoassay and protein binding techniques respectively in plasma from blood taken at 20-min intervals over 24-h periods in 3 normal men, 2 women with Stein-Leventhal syndrome and a man with a benign adrenocortical adenoma. In all subjects but the latter, DHA and cortisol were episodic and synchronous throughout the entire day; in this patient, continuous secretion of cortisol by the tumor apparently abolished stimulation of the contralateral adrenal, and DHA production was negligible. Dehydroisoandrosterone sulfate analysis in plasma displayed a pattern which, probably because of its origin both by secretion and sulfation and its long half-life showed less synchronicity with DHA and cortisol and less fluctuation than did the free hormones.
D000236:Adenoma / Q000097:blood; D000306:Adrenal Cortex Neoplasms / Q000097:blood; D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000097:blood; D011863:Radioimmunoassay; D013464:Sulfuric Acids / Q000097:blood; D013997:Time Factors
D013464:Sulfuric Acids; D003687:Dehydroepiandrosterone; D006854:Hydrocortisone