Antagonism of biogenic amine-induced depression of cerebral cortical neurones by Na+, K+-ATPase in inhibitors.
The effects of iontophoretically applied Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors (ouabain, digitoxin, digitoxigenin, strophanthin K, strophanthidin, thevetin A and B, ethacrynate, and harmaline) on the depression of rat cerebral cortical neurones by noradrenaline, 5-hydroxytryptamine, and histamine have been studied. The inhibitors antagonized depressions of spontaneously active neurones evoked by these amines, but not those evoked by gamma-aminobutyric acid, adenosine, adenosine 5'-monophosphate, or calcium. The antagonistic potencies of the various inhibitors appeared to be proportional to their known potencies as inhibitors of Na+, K+-ATPase. The data therefore support the hypothesis that amines depress central neurones by activating an electrogenic sodium pump.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001679:Biogenic Amines / Q000037:antagonists & inhibitors*; D002301:Cardiac Glycosides / Q000494:pharmacology; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D003864:Depression, Chemical; D004347:Drug Interactions; D004976:Ethacrynic Acid / Q000494:pharmacology; D006246:Harmaline / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D012964:Sodium
D001679:Biogenic Amines; D002301:Cardiac Glycosides; D012701:Serotonin; D006632:Histamine; D012964:Sodium; D006246:Harmaline; D000251:Adenosine Triphosphatases; D004976:Ethacrynic Acid; D011188:Potassium; D009638:Norepinephrine