The effect of hexose monophosphate shunt inhibitors on adenohypophyseal and ceruloplasmin reactions to oestrogen.
Oestradiol benzoate, as an aqueous microcrystal suspension, was administered i.m. to rats in doses of 1 mg twice a week; it induced adenohypophyseal hyperplasia and an increase of the thyroxine-binding capacity of the adenohypophyseal proteins in vitro and raised the blood ceruloplasmin level. The simultaneous administration of a hexose monophosphate shunt inhibitor--6-aminonicotinamide (200 microgram/rat/day in food) or oxythiamine (8 mg/rat/day in food)--did not modify the reaction of the adenohypophysis; the hexose monophosphate shunt thus probably does not play a significant role in the adenohypophyseal reaction to oestrogens. By themselves, both inhibitors raised the blood ceruloplasmin level and their effect summated with that of oestradiol. The mechanism of action of the inhibitors is not known, but a nonspecific stress effect leading to an increase in the ceruloplasmin level as an "acute phase protein" is considered to be the most likely.
D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000818:Animals; D002570:Ceruloplasmin / Q000032:analysis; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006600:Hexosephosphates / Q000037:antagonists & inhibitors; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives*; D010119:Oxythiamine / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D013975:Thyroxine-Binding Proteins
D004967:Estrogens; D006600:Hexosephosphates; D013844:Thiazoles; D013975:Thyroxine-Binding Proteins; D010119:Oxythiamine; D009536:Niacinamide; D015120:6-Aminonicotinamide; D002570:Ceruloplasmin