Experimental investigations on the influence upon the chemical carcinogenesis. IInd communication: studies with 3,4-benzopyrene.
After subcutaneous application of 0.5 mg 3,4-benzopyrene (BP) to Sprague-Dawley-rats on the 2nd day of life, 50% of the animals developed local fibrosarcomas after 250 +/- 70 days. Additional treatment with immunostimulating (BCG, albumin, vitamin A-acid) or immunodepressive agents (hydrocortisone, cyclophosphamide, methotrexat) which was started 6 days after birth and maintained throughout life, did not influence carcinogenesis with respect to tumor incidences and induction periods of tumors.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology*; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012709:Serum Albumin / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology
D001500:BCG Vaccine; D001580:Benzopyrenes; D007166:Immunosuppressive Agents; D012709:Serum Albumin; D014212:Tretinoin