The release of beta glucuronidase from the white cells of patients with drug rashes when incubated in autologous plasma, with and without the addition of the causal drug.
In seven out of 16 patients with drug rashes, the leucocytes selectively released beta glucuronidase when incubated in autologous plasma, indicating the possible presence of immune complexes. When the white cells were incubated with the suspected drug in vitro, they tended to react in three different ways. In four out of 16 cases additional beta glucuronidase was released, perhaps due to the formation of immune complexes, in two out of the 16, beta glucuronidase release was suppressed, perhaps due to antigen excess, and in two cases LDH release was decreased while beta glucuronidase remained unaltered.
D001769:Blood; D003875:Drug Eruptions / Q000201:enzymology* / Q000209:etiology; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology*
D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase