[Depression of contractile function and decrease of the effectiveness of oxygen utilization during compensatory heart hypertrophy].
Heart hypertrophy was produced in rats by creating a coarctation of the aorta 4 months prior to the experiment. The conducted study of the contractile function and oxygen consumption in isolated working hearts demonstrated a marked decrease in the contractile function of the hypertrophied hearts, as compared to the intact ones. Oxygen utilization, however, remained in these preparations equal to that in the controls: hence, the efficacy of oxygen utilization per unit of function was decreased. At the same time, the process of mobilization--glycogen re-synthesis--is highly activated, and glycolysis--accelerated. In order to explain these phenomena it was postulated that the falling efficacy of oxygen utilization and glycogenolysis activation may be caused by a growing calcium concentration in the myoplasm due to the progressive decrease of the capacity of the calcium pump of the sarcoplasmatic reticulum in the process of heart hypertrophy development.
D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats
D006003:Glycogen
Depressiia sokratitel'noĭ funktsii i snizhenie effektivnosti ispol'zovaniia kisloroda pri kompensatornoĭ gipertrofii serdtsa