[On a biochemical model of neurogenic sialosis: studies in rats (author's transl)].
By studying the influence on rat-parotid glands of the antihypertensive drug, guanoxane (Envacar), we attempted to establish a biochemical model of a neurogenic sialosis. Protein content and alpha-amylase activity were determined in gland extracts and in polyacrylamide gel slabs after electrophoretic separation of equal amounts of parotid-gland protein. The values for both parameters showed a marked increase during the first week of treatment as compared with the controls, but decreased subsequently. After electrophoretic separation into 4 isoamylases, the activity per unit protein decreased with time in one group of isoenzymes and increased in another. We interpret these findings as a gradual shift in the isoamylase distribution pattern of the rats' parotid glands with increasing duration of a neurogenic sialosis of the peripheralvegetative type.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D005260:Female; D006146:Guanidines; D007517:Isoamylase / Q000378:metabolism; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012466:Salivary Gland Diseases / Q000139:chemically induced / Q000201:enzymology*; D012469:Salivary Glands / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013997:Time Factors
D006146:Guanidines; D011506:Proteins; D000681:Amylases; D007517:Isoamylase
Uber ein biochemisches Modell neurogener Sialosen