An autoregulatory role for prostaglandins in placental hemodynamics: their possible influence on blood pressure in pregnancy.
This review asserts that prostaglandins of the E family play a vital regulatory role in uteroplacental blood flow. This role appears to be similar to activity within other organs, especially the kidney, in a process referred to as autoregulation of blood flow. This mechanism may serve as a system for ehmodynamic homeostasis in pregnancy. Moreover, hypertension in pregnancy (toxemia) may be due to a specific or generalized abnormality in this system.
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005260:Female; D006706:Homeostasis; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis; D011454:Prostaglandins A / Q000378:metabolism; D011458:Prostaglandins E / Q000502:physiology*; D012039:Regional Blood Flow; D012083:Renin / Q000378:metabolism; D014599:Uterus / Q000098:blood supply
D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D000804:Angiotensin II; D003687:Dehydroepiandrosterone; D012083:Renin