Mixed lymphocyte reactions: augmentation by drugs that inhibit stimulator cell protein synthesis.
Inhibiting the protein synthesis of F1 stimulator cells in a mixed lymphocyte reaction (MLR) can enhance the DNA synthetic response and cytotoxic activity of the responder parental lymphocytes, independent of the number of stimulator cells used. Thus stimulator lymphocytes act not only as a source of antigen but play an additional regulatory role in the MLR.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D004247:DNA / Q000096:biosynthesis*; D004306:Dose-Response Relationship, Immunologic; D007111:Immunity, Cellular; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010142:Pactamycin / Q000494:pharmacology; D013154:Spleen / Q000166:cytology
D010142:Pactamycin; D004247:DNA