title: Faulty DNA repair following ultraviolet irradiation in Fanconi's anemia.
abstract: Fibroblasts from a patient with Fanconi's anemia were deficient in their ability to excise UV-induced pyrimidine dimers from their DNA but were capable of single-strand break production and unscheduled DNA synthesis.
mesh_terms: D000741:Anemia, Aplastic / Q000378:metabolism*; D001665:Binding Sites; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004260:DNA Repair; D004314:Down Syndrome / Q000378:metabolism; D005199:Fanconi Anemia / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D008970:Molecular Weight; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D011830:Radiation Effects; D014466:Ultraviolet Rays
chemical_list: D011742:Pyrimidine Nucleotides; D004247:DNA