Effect of triiodothyronine on the biosynthesis of adenine nucleotides and proteins in the rat heart.
1) During the development of myocardial hypertrophy induced by 3,3',5-triiodo-L-thyronine the enhancement of de novo synthesis of adenine nucleotides occurs very early and precedes the increase of protein synthesis. In this respect there is a striking parallelism with other types of cardiac hypertrophy. 2) The acceleration of adenine nucleotide synthesis under these experimental conditions seems to be due to a greater availability of cardiac 5-phosphoribosyl-1-pyrophosphate. 3) The triiodothyronine-induced enhancement of adenine nucleotide synthesis can be attenuated by beta-receptor-blocking agents.
D000225:Adenine / Q000494:pharmacology; D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D009124:Muscle Proteins / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology*
D000227:Adenine Nucleotides; D009124:Muscle Proteins; D014284:Triiodothyronine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D010754:Phosphoribosyl Pyrophosphate; D000255:Adenosine Triphosphate; D011433:Propranolol; D000225:Adenine