Protease inhibitors reduce the reverse passive Arthus reaction.
Trasylol, ovomucoid, tranexamic acid and soybean inhibitor decrease the vascular permeability as measured by extravasation of 131I-albumin when injected with the antibody at induction of a reverse passive Arthus reaction in the rat skin. Trasylol given systemically also had a suppressive effect, similar to phenylbutazone. When the reaction was induced in the pleural cavity, both Trasylol and tranexamic acid reduced the influx of leucocytes.
D000818:Animals; D001183:Arthus Reaction / Q000188:drug therapy*; D003872:Dermatitis / Q000188:drug therapy; D005260:Female; D010998:Pleurisy / Q000188:drug therapy; D011480:Protease Inhibitors / Q000627:therapeutic use*; D051381:Rats
D011480:Protease Inhibitors