Synthesis of purine and pyrimidine substituted nitroxides.
Reaction of 6-hydrazinopurine and 2-hydrazinopyrimidine with 2, 2, 6, 6-tetramethylpiperidone-1-oxyl gives 2, 2, 6, 6-tetramethylpiperidone-1-oxyl-(6-purinyl) hydrazone (3b) and 2, 2, 6, 6-tetramethylpiperidone-1-oxyl-(2-pyrimidinyl) hydrazone (4b) respectively. Compound 3b is inactive even at high dose levels against TLX/5 lymphoma and 3b and 4b are both inactive in tests using the L1210 leukaemia system.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003497:Cyclic N-Oxides / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D010880:Piperidines / Q000138:chemical synthesis*; D010881:Piperidones / Q000138:chemical synthesis*; D011687:Purines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D003497:Cyclic N-Oxides; D010880:Piperidines; D010881:Piperidones; D011687:Purines; D011743:Pyrimidines