Taming effects of p-chlorophenylalanine on the aggressive behavior of septal rats.
Septal irritability and shock-induced aggression were suppressed by the administration of p-chlorophenylalanine (PCPA) to septal rats. The levels of septal irritability and shock-induced fighting were significantly lower in septal, PCPC-treated rats than in nontreated septal rats. Since both parameters of septal aggression were reduced by PCPA, and while PCPA has no effect on shock-induced fighting of unlesioned rats under similar parameters, it appears that both forms of aggression may function through a common neural mechanism.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D003864:Depression, Chemical; D004597:Electroshock; D010134:Fenclonine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D012686:Septal Nuclei / Q000033:anatomy & histology / Q000502:physiology*; D012688:Septum Pellucidum / Q000502:physiology*
D010134:Fenclonine