[Group-allergic reaction spectrum and sensitization potency of benzylisothiocyanate].
Allergenicity of benzylisothiocyanate and group-allergic cross reactions. Comparative patch-test series made in pateints suffering from contact dermatitis induced by Sulbentin (Dibenzthion)-antimycotics and in guinea pigs, experimentally sensitized to benzylisothiocyanate (BITC), showed: BITC is a potent contact sensitizer and the real hapten in cases of Sulbentin-allergy. Of special importance in this molecule is the benzyl-group. Neither 4,4-diphenylmethandiisocyanate and isophorondiisocyanate (substances used in polyurethane production) nor the closely related methylisothiocyanate (decomposition product of some potato-selecting agents) produced any groupallergic cross reactions in the above-mentioned patients and guinea pigs.
D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects*; D001593:Benzyl Compounds / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D006168:Guinea Pigs; D006801:Humans; D012882:Skin Tests; D013861:Thiocyanates / Q000009:adverse effects*
D000935:Antifungal Agents; D001593:Benzyl Compounds; D013861:Thiocyanates
Untersuchungen zur gruppenallergischen Reaktionsbreite und Sensibilisierungspotenz von Benzylisothiocyanat