Are muscarinic receptors in the central and peripheral nervous system different?
The concentration-dependent binding of atropine-3 H to membrane fractions from bovine tracheal muscle, parotid gland and caudate nucleus, measured by equilibrium dialysis, revealed the presence of virtually identical high affinity binding sites in all three tissues. Sch 1000 and Sch 1178 geometrical isomers of N-isopropylatropine bromide with a large potency ratio as antimuscarinics, inhibited atropine binding identically in all three tissues. Differences in properties of muscarinic receptors in these tissues are either non-existent or too small to be detected by the applied techniques.
D000818:Animals; D001285:Atropine / Q000378:metabolism; D001921:Brain / Q000187:drug effects; D002417:Cattle; D002421:Caudate Nucleus / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D009241:Ipratropium / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010306:Parotid Gland / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects*; D011950:Receptors, Cholinergic; D014132:Trachea / Q000187:drug effects
D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D001285:Atropine; D009241:Ipratropium