Effect of albumin on uncoupling of oxidative phosphorylation by chinoform in rat liver mitochondria.
Addition of serum albumin diminished the uncoupling effect of chinoform on oxidative phosphorylation in rat liver mitochondria. Upon increasing the concentration of magnesium ions in the medium, the action of serum albumin was diminished. These results indicate that serum albumin combines with chinoform in competition with magnesium ions.
D000818:Animals; D002417:Cattle; D007464:Clioquinol / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption; D051381:Rats; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D014475:Uncoupling Agents
D014475:Uncoupling Agents; D012710:Serum Albumin, Bovine; D007464:Clioquinol; D008274:Magnesium