[Rat brain Mg2+-ATPase activity and Ca2+ and Mg2+ concentration in the presence of amizil and arecoline].
The effect of benactyzine (the central cholinolytic) in a dose of 40 mg/kg and arecoline (cholinomimetic) in a dose of 2.5 mg/kg on the activity of Mg2+-dependent ATP-ase and the content of Ca2+ and Mg2+ ions in the brain was studied in rats. It was shown that benactyzine and arecoline evoked a biphasic change in the activity of the enzyme and the electrolyte content. A conclusion was drawn that the enzyme inhibition was connected with the accumulation of Ca2+ ions in the brain tissue, whereas its inhibition--with the Mg2+ ion accumulation. It is supposed that throught these effects benactyzine and arecoline influenced the release and retention of the neuromediators in the tissue depot.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001535:Benactyzine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051381:Rats; D013997:Time Factors
D001115:Arecoline; D001535:Benactyzine; D000251:Adenosine Triphosphatases; D008274:Magnesium; D002118:Calcium
Aktivnost' Mg2+-ATF-azy i soderzhanie ionov Ca2+ i Mg2+ v mozge krys pri deĭstvii amizila i arekolina.