title: Development of Na+-K+-ATPase in neonatal rat brain synaptosomes after perinatal protein malnutrition.
abstract: Four protein dietary groups of rats were used in this study, namely: 27% casein diet fed throughout gestation and lactation (group C-C); 27% gestation, 10% lactation (group C-D); 10% gestation, 27% lactation (group D-C); 10% throughout gestation and lactation (group D-D). Mean body weight of group D-D at warning was 19 g compared with 59 g for group C-C. The specific activity of Na+-K+-ATPase in isolated synaptosomes from cerebral and cerebellar tissues increases throughout the lactation period. At 1 and 7 days of age no differences in Na+-K+-ATPase activity are noted in the brain regions of Groups C-C and D-D. At 14 and 21 days, however, the specific Na+-K+-ATPase activity was significantly reduced in isolated synaptosomes from both brain regions of the protein-deprived group. ATPase activity in cerebellar synaptosomes from dietary exchange groups (C-D and D-C) developed to the same extent as that of the control group (C-C) after 21 days of lactation. ATPase activity in the cerebral synaptosomes of the dietary exchange group (C-D) did not develop to the same extent as that in the control group (C-C) and the other dietary exchange group (D-C).
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D004044:Dietary Proteins; D005260:Female; D005333:Fetus / Q000502:physiology; D005865:Gestational Age; D006128:Growth; D006651:Histocytochemistry; D007774:Lactation; D008431:Maternal-Fetal Exchange; D008928:Mitochondria / Q000201:enzymology; D011188:Potassium / Q000378:metabolism; D011247:Pregnancy; D011488:Protein Deficiency / Q000201:enzymology*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013569:Synapses / Q000201:enzymology*; D013997:Time Factors
chemical_list: D004044:Dietary Proteins; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium