Behavioral evidence for the stimulation of CNS serotonin receptors by high doses of LSD.
Systemic administration of lysergic acid diethylamide (LSD) to rats induces a behavioral syndrome--consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading--which is a reflection of increased activation of central serotonin receptors. Utilizing this behavioral measure, a marked supersensitivity to LSD was observed in rats whose serotonin nerve terminals had been selectively destroyed, and a dramatic tolerance to LSD was observed following its repeated administration to normal rats. These data provide direct evidence that LSD can stimulate CNS serotonin receptors to a degree which markedly affects behavior.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000032:analysis / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000032:analysis / Q000134:cerebrospinal fluid; D014363:Tryptamines / Q000494:pharmacology
D002395:Catecholamines; D011985:Receptors, Serotonin; D014363:Tryptamines; D012701:Serotonin; D008238:Lysergic Acid Diethylamide; D010134:Fenclonine; D003891:Desipramine