title: Renal failure during intermittent rifampicin therapy.
abstract: Two patients who developed reversible renal failure during intermittent rifampicin therapy are described. Both had febrile reactions to rifampicin. The first was also found to have uraemia associated with swelling of the glomerular endothelial cells. The second developed tubular necrosis unassociated with haemolysis or shock. The pathogenesis of the renal lesion in these two patients, as revealed by light microscopy, immunofluorescence studies and electron microscopy, is discussed.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D000906:Antibodies / Q000032:analysis; D004727:Endothelium / Q000473:pathology; D004977:Ethambutol / Q000008:administration & dosage; D005334:Fever / Q000139:chemically induced; D005337:Fibrin / Q000032:analysis; D006801:Humans; D007105:Immune Complex Diseases / Q000139:chemically induced; D007511:Ischemia / Q000209:etiology; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000098:blood supply / Q000473:pathology; D008297:Male; D009336:Necrosis; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy; D014511:Uremia / Q000139:chemically induced
chemical_list: D000906:Antibodies; D004977:Ethambutol; D005337:Fibrin; D012293:Rifampin