title: Treatment of uncomplicated gonorrhoea with spectinomycin hydrochloride (Trobicin).
abstract: 110 patients with uncomplicated gonococcal urethritis were treated with 2 g spectinomycin (Trobicin) intramuscularly. Seventy-five patients were available for follow-up and there was only one treatment failure, giving a cure rate of 98-6%. Of the 99 gonococcal isolates, 59 were sensitive to 5 microng/ml of spectinomycin or less and 40 were sensitive to 10 microng/ml. In a small sample of patients 2 g spectinomycin intramuscularly produced a serum concentration averaging 100 microng/ml after one hour.
mesh_terms: D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D000198:Spectinomycin / Q000097:blood / Q000627:therapeutic use*; D014526:Urethritis / Q000188:drug therapy
chemical_list: D000198:Spectinomycin