Inadequacies and hazards of chymopapain injections as treatment for intervertebral disc disease.
Chymopapain chemonucleolysis was performed on 100 patients with primary lumbar intervertebral disc disease. The results were compared with those of 174 patients who underwent laminotomy, foraminotomy, and discectomy. Primary lumbar intervertebral disc disease was arbitrarily divided into degenerative, complex, previous surgical, and simple disc syndromes. No difference was seen between chemonucleolysis and surgery in the first three divisions; between 55 percent and 60 per cent of patients responded successfully to treatment. In the simple disc division 89 per cent of the surgical and 60 per cent of the chemonucleolysis patients had successful results.
D000328:Adult; D000818:Animals; D001100:Arachnoiditis / Q000139:chemically induced; D001416:Back Pain / Q000139:chemically induced; D002415:Cats; D002561:Cerebrovascular Disorders / Q000139:chemically induced; D002917:Chymopapain / Q000009:adverse effects* / Q000494:pharmacology / Q000633:toxicity; D004285:Dogs; D004342:Drug Hypersensitivity / Q000209:etiology; D010450:Endopeptidases / Q000009:adverse effects*; D006261:Headache / Q000139:chemically induced; D006429:Hemiplegia / Q000139:chemically induced; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D007403:Intervertebral Disc / Q000187:drug effects; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*; D010264:Paraplegia / Q000139:chemically induced; D011817:Rabbits; D012677:Sensation; D013035:Spasm / Q000139:chemically induced; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced; D013577:Syndrome; D001750:Urinary Bladder, Neurogenic / Q000139:chemically induced
D010450:Endopeptidases; D002917:Chymopapain