title: [Change of toxicity and carcinogenicity of N-methyl-N-nitrosobenzylamine in rats by methylsubstitution in the phenylresidue].
abstract: Substitution with a methyl group in the 2-, 3- or 4-position respectively of the phenyl moiety of N-methyl-N-nitrosobenzylamine results in a considerable reduction of the acute toxicity. (LD 50 of MNBA: 18 mg/kg (Druckrey et al., 1967), 2-Me-MNBA: 90 mg/kg, 3-Me-MNBA: 600 mg/kg, 4-Me-MNBA: 400 mg/kg). However, the introduction of the methyl group influences the carcinogenic activity of MNBA in rats and its organotropy, only to a small extent. Long-term administration of 5 and 15 ppm respectively of the isomeric N-nitroso compounds in the drinking water produces in all animals carcinomas of the oesophagus and the pharynx.
mesh_terms: D000818:Animals; D004938:Esophageal Neoplasms / Q000139:chemically induced; D007928:Lethal Dose 50; D009374:Neoplasms, Experimental; D009602:Nitrosamines / Q000494:pharmacology*; D009928:Organ Specificity; D010610:Pharyngeal Neoplasms / Q000139:chemically induced; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D009602:Nitrosamines
vernacular_title: Veränderung der Toxizität und Carcinogenität von N-Methyl-N-nitrosobenzylamin durch Methyl-substitution am Phenylrest bei Ratten