title: [Changes in serum osmolarity after high contrast doses during angiography].
abstract: Analysis of changes in osmolarity of the serum after various doses of hypertonic radiographic contrast media, following a single injection, showed an initial rise of about 35 m/mosm/1, followed by a rapid fall in osmolarity with a subsequent short hypo-osmolar phase. With repeated injections, similar changes are found if the intervals between the injections are long enough. Following repeated injections over a short interval, there may be a more prolonged phase of hyperosmolarity. In this phase of delayed dehydration, there may be clinical complications. Possible forms of treatment are discussed.
mesh_terms: D000792:Angiography / Q000009:adverse effects; D001769:Blood / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009994:Osmolar Concentration; D009995:Osmosis / Q000187:drug effects
chemical_list: D003287:Contrast Media
vernacular_title: Verhalten der Serumosmolarität bei hohen Kontrastmitteldosen im Rahmen der Angiographie