Spleen and lymph node reticulofibrosis in "chemically thyroidectomized" rats.
The effects of the X-rays on the peripherial lymphoid organs (lymph nodes and spleen) in male adult wistar rats "chemically thyroidectomized" (methylthiouracil) have been studied. Spontaneous death of these animals 9 days after the irradiation was determined by the hypoplasia (aplasia) of the hematogenous bone marrow. The spleen and lymph node changes -- represented by the lymphoid tissue depletion and reticulofibrosis -- in the experimental animals were similar to those observed in animals sacrificed 6-8 months after irradiation. They differed from the latter by the absence of the macromolecular hyperstability of the reticular and collagenous fibers, which is proper to early ageing by X-rays.
D000375:Aging; D000818:Animals; D007037:Hypothyroidism / Q000139:chemically induced*; D008099:Liver / Q000528:radiation effects; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008779:Methylthiouracil; D051381:Rats; D013154:Spleen / Q000473:pathology* / Q000528:radiation effects; D013961:Thyroid Gland / Q000473:pathology
D008779:Methylthiouracil