[The effect of Mn2+ on thyroid iodine metabolism in rats].
Injection into rats of manganous chloride (2 mg/100 g) showed, after a 24-hr period, a marked depression of thyroidal 131I uptake. There is a decrease in serum T3 and T4 levels and an increase in I- level. These results demonstrate that the action of manganous ions is to block uptake of I- by the thyroid.
D000818:Animals; D003864:Depression, Chemical; D007455:Iodine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D008345:Manganese; D007455:Iodine; D013974:Thyroxine
Action des ions Mn2+ sur le métabolisme iodé thyroïdien du Rat.