[Renal blood flow after selective injection of different dosages of diatrizoate into the renal artery. An experimental study in the dog (author's transl)].
The characteristic biphasic renal haemodynamic response to diatrizoate injected into the renal artery was shown in the dog with the 133-Xenon washout technique. A brief increase in renal blood flow (RBF) during the first ten seconds is followed by a more prolonged period of diminuished RBF. A dose of 4 ml. diatrizoate 60% resulted in the maximum RBF increase of 43% after ten seconds, but even 1 ml. diatrizoate raised the RBF 24%. The initial vasodilator effect of diatrizoate compares well in its extent with the most potent renal vasodilators.
D000818:Animals; D003973:Diatrizoate / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000098:blood supply*; D008657:Metabolic Clearance Rate; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*; D014980:Xenon Radioisotopes
D014665:Vasodilator Agents; D014980:Xenon Radioisotopes; D003973:Diatrizoate
Nierendurchblutung nach selektiver Injektion von verschiedenen Dosen Diatrizoat in die Nierenarterie. Eine experimentelle Untersuchung beim Hund