[The influence of rheologic properties of the blood on adaptive processes in the myocardium].
Changes in rheological properties of the blood were produced by intravenous injection of a high-molecular weight dextran and lysin-vasopressin. The animals were decapitated in one hour. Oxygen absorption by mitochondria of the heart in oxidation of 2.5-10 mM of the succinate increased by 90-120%, as compared to control. Stimulation of respiration by ADP was decreased 1.5-2 times. Simultaneous administration of the succinate and glutamic acid normalized the respiration and phosphorylation. A possibility of inhibition of succinic-dehydrogenase by the oxalo-acetic acid was suggested. Switching of respiration to succinic acid and limiting of the SDG activity can be considered as adaptive factors under conditions of changes in rheological properties of the blood, and are directed to the maintenance of cardiac activity, this being evidenced by the absence of changes in the ATP-asic activity and in the myosin content of the heart.
D000222:Adaptation, Physiological; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D002682:Chinchilla; D003326:Coronary Circulation; D005971:Glutamates / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure*; D009218:Myosins; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011817:Rabbits; D013386:Succinates / Q000378:metabolism
D005971:Glutamates; D013386:Succinates; D000244:Adenosine Diphosphate; D000251:Adenosine Triphosphatases; D009218:Myosins
O vliianii izmeneniia reologicheskikh svlĭstv krovi na adaptatsionnye protsessy v miokarde