title: [Possible disorder of tissue immunity function in mothers who have given birth to a child with Down's disease].
abstract: The rates of DNA synthesis were studied in PHA-stimulated lymphocytes from the peripheral blood of mothers giving birth to a child with Down's disease. For control purposes a group of donors of the same age and sex were studied as wells. A decrease of 3H-thymidine incorporation was detected in the lymphocytes of the mothers of such children. The found differences were due to a drop of lymphocyte PH-reactivity in the older maternal age group (over 30 years). Interrelation between the changed function of the maternal immune system and the birth of children with chromosome unbalance are discussed.
mesh_terms: D000328:Adult; D000367:Age Factors; D004247:DNA / Q000096:biosynthesis; D004314:Down Syndrome / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
chemical_list: D037102:Lectins; D004247:DNA; D013936:Thymidine
vernacular_title: O vozmozhnom narushenii funktsii tkanevogo immuniteta u matereĭ, rodivshikh rebenka s bolezn'iu Dauna.