Effect of foreign innervation on contractile and histochemical properties of the transplanted levator ani muscle of the rat.
Heterotopic transplantation of the levator ani (LA) muscle into the bed of the fast tibialis anterior (TA) or slow soleus (SOL) muscle respectively results in transformation of contractile and histochemical properties of the muscle dependent on the new "foreign" innervation. This transformation is observed after transplantation of minced muscle tissue and of free grafts. The result of transformation is more pronounced in the case of free LA-TA grafts which show progressive shortening of contractile response, whereas the LA-SOL shows slight shortening. The heterotopically transplanted free LA-SOL and the LA-TA grafts become relatively faster than the respective original muscle, suggesting operation of myogenic factors related to the fast LA muscle. Maximal tetanic tension output of the free heterotopic grafts 60 days after transplantation recovers to only about a quarter of the correspondong control muscles. Recovery of speed of contraction in the transplanted LA muscle is similar to that observed after selfreinnervation after crushing the pudendal nerve close to its entry into the muscle. In the heterotopically transplanted muscles the reversal of the originally uniform histochemical fibre pattern to a mixed fibre pattern in respect to ATPase and SDH activity is dependent on the type of innervation. After selfreinnervation of the LA muscle by the pudendal nerve a uniform fibre pattern is maintained with regeneration of the nerve.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D001003:Anal Canal; D000818:Animals; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction; D009132:Muscles / Q000201:enzymology / Q000294:innervation / Q000637:transplantation*; D009469:Neuromuscular Junction / Q000502:physiology; D051381:Rats; D013997:Time Factors; D014182:Transplantation, Autologous
D007931:Leucyl Aminopeptidase; D000251:Adenosine Triphosphatases