[Inhibition of compensatory kidney hypertrophy by hypothyroidism in the rat. Measurement of the mean diameter of glomeruli and proximal tubules].
The body, heart and kidney weights are reduced in the hypothyroid rat. In this animal, the diameter of the proximal tubule is significantly smaller than in euthyroid controls. The glomerular diameter is not affected by hypothyroidism. 21 days after uninephrectomy, the weight of the remaining kidney and the diameter of the proximal tubule increase significantly both in the hypothyroid and the euthyroid rats. But this compensatory renal hyperthrophy is definitely impaired in the hypothyroid animals.
D000818:Animals; D001835:Body Weight; D005260:Female; D006984:Hypertrophy; D007037:Hypothyroidism / Q000139:chemically induced / Q000473:pathology*; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000473:pathology; D009392:Nephrectomy; D009929:Organ Size; D051381:Rats
Inhibition de l'hypertrophie rénale compensatrice par l'hypothyroïde chez le rat. Mesure du diamètre moyen des glomérules et des tubes proximaux.