title: [Effect of guanidine dderivatives on choline acetylase and acetylcholinesterase of the rabbit brain].
abstract: The effects of 14 guanidino compounds on the activity of rabbit brain choline acetyltransferase (CAT) and acetylcholine esterase (ACE) have been studied, comparatively with that of pentylentetrazol. No guanidino compound examined nor pentylentetrazol had an effect on CAT activity. 4 of them showed a moderate inhibitory effect on ACE, of the same order of magnitude as that of pentylentetrazol, but significantly lower than that of the specific inhibitors eserine and mytelase.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D007700:Kinetics; D011817:Rabbits
chemical_list: D006146:Guanidines; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase
vernacular_title: Effet des dérivés quanidiques sur la cholinacétylase et sur l'acétylcholinestérase du cerveau de Lapin.