Stimulation of mixed lymphocyte cultures and cytotoxic responses: evidence that T cells express SD but not LD antigens, whereas B cells express both.
By separating T and B cells from stimulator spleens it has been found that mixed lymphocyte response (MLR) and cytotoxic cells are generated in responder T cell populations by B but not by T stimulator cells in a wide variety of strain combinations. It is suggested that MLR-stimulating or LD antigens are expressed on B but not T cells, and that their presence is necessary in order to generate cototoxic responses to H-2K and/or H-2D (or SD) antigens which are present on both T and B cells. The finding that B cells and macrophages stimulate MLR is consistent with the hypothesis that Ia antigens, expressed on both these cell types but not on nylon column purified peripheral T cells, are the MLR-stimulating or LD determinants.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D007519:Isoantigens; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000528:radiation effects; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014965:X-Rays
D006649:Histocompatibility Antigens; D007519:Isoantigens; D008934:Mitogens