title: The production of cardiac hypertrophy by tri-iodothyroacetic acid.
abstract: Severe cardiac hypertrophy has been produced experimentally in rats by long-term, low-dose treatment with tri-iodothyroacetic acid. The dose used was insufficient to cause any apparent systemic or metabolic effect. It is suggested that similar iodinated substances in the blood in man, resulting from normal or abnormal thyroid hormone catabolism, may be causally related to some forms of cardiomyopathy.
mesh_terms: D000085:Acetates; D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D004195:Disease Models, Animal; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006352:Heart Ventricles / Q000473:pathology; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014284:Triiodothyronine / Q000031:analogs & derivatives*
chemical_list: D000085:Acetates; D014284:Triiodothyronine; D006003:Glycogen; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase