title: The composition of connective tissue macromolecules from bovine respiratory system.
abstract: Connective tissue macromolecules, glycosaminoglycans, glycoproteins, collagen, and elastin were isolated from different parts of the respiratory system and characterized. The materials included bronchiolar tissue, gas-exchange tissue, lung pleura, and tracheal mucosa. The similarity of the macromolecular composition of lung pleura and tracheal mucosa suggests a common cellular component in these structures. The high concentration of GAG and collagen in bronchiolar tissue is consistent with the cartilagenous nature of this tissue. Particularly interesting is the high content of heparin in all pulmonary structures, a relatively greater content of hyaluronic acid in gas-exchange tissue, and a high content of heparan sulfate and dermatan sulfate in vascular tissues. Elastin also occurs as a major fibrous structure. Although the biologic role of these connective tissue macromolecules has not been established, certain functional relationships are inferred.
mesh_terms: D000818:Animals; D001980:Bronchi / Q000032:analysis; D002417:Cattle; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000032:analysis*; D004549:Elastin / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis*; D006025:Glycosaminoglycans / Q000032:analysis*; D006493:Heparin / Q000032:analysis; D006497:Heparan Sulfate / Q000032:analysis; D008168:Lung / Q000032:analysis; D010994:Pleura / Q000032:analysis; D012137:Respiratory System / Q000032:analysis*; D014132:Trachea / Q000032:analysis; D014574:Uronic Acids / Q000032:analysis
chemical_list: D003094:Collagen; D004549:Elastin; D006023:Glycoproteins; D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate; D014574:Uronic Acids