Effect of fasting and streptozotocin-diabetes on the coronary flow in isolated rat hearts: A possible role of endogenous catecholamines and prostaglandins.
The coronary flow rate of retrogradely perfused hearts from fasted (group I) and streptozotocin-diabetic rats (group II) is increased when compared with the flow rate of control, fed animals (group III). The enhanced coronary flow is absent when hearts of groups I and II are perfused in the presence of indomethacin (1 microgram/ml) in the perfusion fluid and the lowest flow rates are observed after depletion of the endogenous catecholamines by reserpin. Hearts from groups I and II showed a marked increase in prostaglandin-release which was counteracted both in the presence of indomethacin (1 microgram/ml) and by reserpin-pretreatment. The results suggest that the increased coronary flow rates in hearts from fasted and streptozotocin-diabetic rats are mediated by an effect of released endogenous catecholamines on coronary vascular smooth muscle and by a catecholamine-induced release of vasodilatory, prostaglandin-like substances.
D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D003326:Coronary Circulation; D003920:Diabetes Mellitus / Q000139:chemically induced; D005215:Fasting; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013311:Streptozocin
D002395:Catecholamines; D011453:Prostaglandins; D013311:Streptozocin; D012110:Reserpine; D007213:Indomethacin