title: The effect of some bacterial products on temperature and sleep in rat.
abstract: The lipopolysaccharides from P. aeruginosa, S. minnesota and mucopeptide from Streptococcus group A injected intravenously into rats induce a dose-dependent changes of temperature. Simultaneously, a profound disturbance of sleep occurs. The administration of salicylate, which markedly suppressed the fever does not influence the mucopeptide-caused sleep disturbance. The most prominent change in the sleep pattern is a marked decrease of the total time of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine (5-HT) and noradrenaline (NA) in hypothalamus and midbrain, areas involved in temperature and sleep control, after injection of streptococcal mucopeptide demonstrated a significant increase of 5-HT turnover in both areas during fever and paradoxical sleep deprivation. Small electrolytic lesions of the dorsal raphe nuclei which are the largest collection of neural cells containing 5-HT completely eliminated the pyrogenic potency of mucopeptide. The findings suggest that some bacterial products might increase the body temperature through the interference with activity of 5-HT-containing neurons of the raphe complex.
mesh_terms: D001831:Body Temperature; D005334:Fever / Q000188:drug therapy; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D009088:Mucoproteins / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000032:analysis; D012459:Salicylates / Q000627:therapeutic use; D012475:Salmonella / Q000032:analysis; D012701:Serotonin / Q000378:metabolism; D012894:Sleep Stages; D012893:Sleep Wake Disorders / Q000209:etiology*; D013297:Streptococcus pyogenes / Q000032:analysis
chemical_list: D008070:Lipopolysaccharides; D009088:Mucoproteins; D012459:Salicylates; D012701:Serotonin; D009638:Norepinephrine