title: Ultrastructural studies on hydantoin induced lymphomas in mice.
abstract: Ultrastructural studies were done on cells from original tumors and from short time cultures of mouse thymic lymphomas experimentally induced by chronic exposure to diphenyl-hydantoin. The tumors appeared in mouse strains with low (C57Bl) and high (SJL/J) susceptibility to spontaneous lymphoma development and were not observed in a resistant strain (C3Hf). Thymic lymphoma development was usually preceded by increasing lymphoreticular atrophy followed by progressive reticulohistiocytic hyperplasia, and subsequently spread to other tissues. Morphologically the tumor was characterized as a lymphoblastic lymphoma. Abnormal cell changes in the original tumors and cultured cells, and the presence of murine C-type particles in the cultured cells but not in the original tumors, are discussed in relation with the disturbance of immune system and the lymphoma enhancement produced by diphenyl-hydantoin.
mesh_terms: D000818:Animals; D005260:Female; D006827:Hydantoins / Q000009:adverse effects*; D008223:Lymphoma / Q000139:chemically induced / Q000648:ultrastructure*; D051379:Mice; D010672:Phenytoin / Q000009:adverse effects
chemical_list: D006827:Hydantoins; D010672:Phenytoin