Reciprocal translocation, 4q-; 21p+, giving rise to Down's syndrome.
A reciprocal translocation is described, t(4;21)(q27;p11), which occurs in a balanced carrier mother and her Down's syndrome child, 47,XX,t(4q-;21p+),+21. A review is presented of Down's syndrome associated with reciprocal translations involving chromosome No. 21.
D000328:Adult; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007198:Indians, North American; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D014178:Translocation, Genetic