title: Sebum: analysis by infrared spectroscopy. II. The suppression of fatty acids by systemically administered antibiotics.
abstract: Various tetracyclines and erythromycins have been used rather empirically for the systemic treatment of acne vulgaris for more than a decade. It has been impossible to accurately evaluate clinically the numerous derivatives and to compare their effectiveness with other antibiotics such as clindamycin. As a substitute for this approach, this present study ranks these antibiotics, when given orally, as to their effectivensss in suppressing the fatty acids in sebum in normal volunteers. As a group, the tetracyclines were more effective than the erythromycins in decreasing the fatty acids, but clindamycin was significantly more potent than either.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002751:Chlortetracycline / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003707:Demeclocycline / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use*; D004952:Esters / Q000032:analysis; D005227:Fatty Acids / Q000037:antagonists & inhibitors*; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use; D012629:Sebum / Q000032:analysis*; D013055:Spectrophotometry, Infrared; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D004952:Esters; D005227:Fatty Acids; D002981:Clindamycin; D003707:Demeclocycline; D004917:Erythromycin; D013752:Tetracycline; D008911:Minocycline; D002751:Chlortetracycline