[Action of some bis-quaternary derivatives of fluorene and related compounds on the skeletal muscles of vertebrates].
In experiments with skeletal muscles of cats, rats and frogs bis-trimethylammonium derivatives of fluorene are shown capable of being strong muscle relaxants of the depolarizing type of action and that the presence of sulfamide or ester groups in the chain between nitrogen atoms is not indispensable for their high activity.
D000009:Abdominal Muscles / Q000187:drug effects; D000818:Animals; D002415:Cats; D003964:Diaphragm / Q000187:drug effects; D005449:Fluorenes / Q000494:pharmacology*; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects; D013329:Structure-Activity Relationship; D013977:Tibia
D005449:Fluorenes; D011950:Receptors, Cholinergic
Deĭstvie nekotorykh bischetvertichnykh proizvodnykh fluorena i rodstvennykh soedineniĭ na skeletnye myshtsy pozvonochnykh