[The cell wall fractions of Brucella are specific mitogens. Implications in the genesis of the primary immune response].
Phenol-water extracts from smooth B. melitensis or B. abortus induce specific proliferation of lymphocytes from Brucella-sensitized men or animals. These extracts have no effect on lymphocytes of uninfected subjects. Above findings imply that an antigen will not trigger the so-called primary response when administered to a immune virgin animal.
D000818:Animals; D002002:Brucella / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology*; D002473:Cell Wall; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects*; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008934:Mitogens; D011135:Polysaccharides, Bacterial / Q000276:immunology*
D008070:Lipopolysaccharides; D008934:Mitogens; D011135:Polysaccharides, Bacterial
Les fractions pariétales des Brucella sont des mitogènes spécifiques. Implications dans la genèse de la réponse immune primaire.