Ultrastructural morphometric investigations on human platelets after long-term ingestion of oral contraceptives.
Platelets from healthy females, who were taking oral contraceptives over a long period of time, were investigated by ultrastructural morphometry. The size, shape, relative volumes, numerical and surface densities of the platelets and their organelles were measured. In 'long-term pill users' the platelets showed a significant increase in the area of section profile. Further changes as, for example, increased volume of platelet granules, reduced number of mitochondria, decreased volume and surface of the open canalicular system, and increased surface of the dense tubular system are to be noted.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008854:Microscopy, Electron; D009940:Organoids / Q000187:drug effects
D003276:Contraceptives, Oral