[Effect of N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone on RNA-and protein synthesis as well as metabolism of synchronously growing yeast cells (Saccharomyces cerevisiae) (author's transl)].
N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone inhibit the influx of [6-3H]-uracil and L-[U-14C]leucin in yeast cells as well as the incorporation in RNA and protein. Experiments with synchronously and asynchronously growing cells showed the N-methyl-N-beta-chloroethylhydrazine essentially influences the dividing phase while the benzaldehydhydrazone is more effective in the growth phase. The effect of these two substances on respiration, glycolysis and the concentration of fructose-1,6-diphosphate, triose phosphate, and adenosine triphosphate is small.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D002455:Cell Division / Q000187:drug effects; D005636:Fructosephosphates / Q000378:metabolism; D005656:Fungal Proteins / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology*; D006835:Hydrazones / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013403:Sugar Phosphates / Q000378:metabolism; D014306:Trioses; D014498:Uracil / Q000378:metabolism; D014500:Uracil Nucleotides / Q000096:biosynthesis
D005636:Fructosephosphates; D005656:Fungal Proteins; D006834:Hydrazines; D006835:Hydrazones; D013403:Sugar Phosphates; D014306:Trioses; D014500:Uracil Nucleotides; D014498:Uracil; D012313:RNA; D000255:Adenosine Triphosphate; D007930:Leucine; D005947:Glucose
Zur Wirkung von N-Methyl-N-beta-chloräthylhydrazin und seinem Benzaldehydhydrazon auf die RNA- und Proteinsynthese sowie Stoffwechsel von synchronisierten Hefezellen (Saccharomyces cerevisiae)