The steroid profile of a virilizing ovarian tumor.
A case report of a 25-year-old female with a sex cord stromal virilizing ovarian tumor is presented. The pathway of ovarian steroid secretion in this tumor is elucidated with the dominant elements being pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, androstenedione, and testosterone. The tumor primarily made testosterone (T) with lesser elevations of androstenedione (A), dehydroepiandrosterone (DHEA), and dihydrotestosterone (DHT). Expert pathologic opinions differed whether this neoplasm was a Sertoli-Leydig tumor or a virilizing granulosa tumor; therefore, it was probably a gynandroblastoma. A unilateral salpingo-oophorectomy was performed and the patient promptly resumed normal ovarian function with ovulation.
D006907:17-alpha-Hydroxypregnenolone / Q000378:metabolism; D000328:Adult; D000735:Androstenedione / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006908:Hydroxyprogesterones / Q000378:metabolism; D007984:Leydig Cell Tumor / Q000473:pathology; D018309:Neoplasms, Gonadal Tissue / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D011284:Pregnenolone / Q000378:metabolism; D012707:Sertoli Cell Tumor / Q000473:pathology; D013739:Testosterone / Q000378:metabolism; D014770:Virilism / Q000209:etiology*
D006728:Hormones; D006908:Hydroxyprogesterones; D013196:Dihydrotestosterone; D006907:17-alpha-Hydroxypregnenolone; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011284:Pregnenolone