title: An enzyme histochemical study of non-Hodgkin's lymphoma and allied disease.
abstract: The enzyme activity for alpha-naphthyl-acetate esterase, naphthol-AS-acetate esterase, naphthol-AS-D-chloroacetate esterase, acid phosphatase, L(+)-tartrate-resistant acid phosphatase, adenosine triphosphatase, and 5'-nucleotidase was examined on the neoplastic cells of giant follicular lymphoblastoma, the so-called reticulum cell sarcoma and Sézary syndrome. The neoplastic cells of giant follicular lymphoblastoma showed distinct activity for adenosine triphosphatase and 5'-nucleotidase, and those of the so-called reticulum cell sarcoma had no characteristic nature of the reticulum cells or histiocytes enzyme histochemically. These findings suggest that these neoplastic cells may be derived from the B-cell system. In Sézary syndrome, acid phosphatase activity was localized in a small paranuclear area in Sézary cells, which were considered to have a T-cell nature. It is thought that these enzyme histochemical methods are easy and useful in differentiating the B- or T-cell nature and the classification of non-Hodgkin's lymphomas.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000251:Adenosine Triphosphatases / Q000032:analysis; D000328:Adult; D000368:Aged; D004950:Esterases / Q000032:analysis; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008206:Lymphatic Diseases / Q000201:enzymology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology*; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009280:Naphthaleneacetic Acids; D009283:Naphthol AS D Esterase / Q000032:analysis; D009708:Nucleotidases / Q000032:analysis
chemical_list: D009280:Naphthaleneacetic Acids; D004950:Esterases; D009283:Naphthol AS D Esterase; D009708:Nucleotidases; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases