Effect of harmine and brain lesions on apomorphine induced motor activity.
Application of harmine (10 mg/kg IP) 30 min before apomorphine decreased the motoric effects of the latter. Following harmine an increase in 5-HT and a decrease in 5-HIAA in different brain regions have been found. Injection of 5,6-DHT into nucleus medianus raphe 7 days before the experiment caused a significant increase of the apomorphine effect. Harmine pretreatment reduced this escessive motility as well as additional lesion of the substantia nigra with 6-OH-DA. Lesion induced by 6-OH-DA alone was without significant effect on the hypermotility following apomorphine. Application of PCPA 3 days before testing elicited an increase of apomorphine-induced hypermotolity which could be abolished by preceding harmine application. The experiments demonstrate the inhibitory effect of the central serotoninergic system on the apomorphine syndrome as well as the serotoninergic-dopaminergic interaction in hypermotility.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000502:physiology*; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006247:Harmine / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors
D000470:Alkaloids; D006892:Hydroxydopamines; D012701:Serotonin; D006247:Harmine; D001058:Apomorphine; D010134:Fenclonine; D015115:5,6-Dihydroxytryptamine