[Effect of blockers of serotonin and noradrenaline synthesis on learning with emotionally different reinforcement in rats].
The effect of inhibitor of serotonin and norepinephrine synthesis in the brain on learning was investigated in rats with emotionally different reinforcement. Parachlorphenylalanine (320 mg/kg) was shown to inhibit learning with food reinforcement, but facilitated learning with pain reinforcement. Disulfiram (100 mg/kg) inhibited learning with pain reinforcement considerably, but failed to influence learning with food reinforcement. Alpha-methyl-m-thyrosine inhibited both forms of learning. These new facts are in line with our previous data on mediating role of the brain monoaminergic systems between emotions and memory.
D000818:Animals; D001921:Brain / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D004221:Disulfiram / Q000494:pharmacology; D004644:Emotions / Q000502:physiology*; D010134:Fenclonine / Q000494:pharmacology; D005502:Food; D007858:Learning / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010146:Pain; D051381:Rats; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000502:physiology*
D012701:Serotonin; D010134:Fenclonine; D004221:Disulfiram; D009638:Norepinephrine
Vliianie blokatorov sinteza serotonina i noradrenalina na obuchenie krys pri émotsional'no razlichnom podkreplenii.