[The pharmaco-kinetics of angiographic contrast media with special reference to the extra-vascular spaces. Fundamental studies on dog for the characterisation of angiographic media. I The pharmaco-kinetics of various contrast media under conditions of constant infusion (balanced flow)].
The pharmaco-kinetics of angiographic contrast media in the extra-vascular space, which are largely unknown, were investigated experimentally in dogs. As part of a basic study, using radio-active contrast media, it was possible to determine the concentration and rate of elimination in practically all organs and tissues. Measurements were carried out first after prolonged infusion of the contrast under conditions of balanced flow, and secondly six hours after the end of the infusion. It was therefore possible to determine the inflow and loss of contrast medium in various organs, or organs systems. The most commonly used angiographic contrast media  in Germany were investigated. Their kinetic behaviour is largely identical, their pattern of distribution and elimination depended principally on the organ or tissue. A comprehensive discussion of the results of all the experiments will be given in the third article.
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000378:metabolism*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000378:metabolism; D004285:Dogs; D005260:Female; D007451:Iodamide / Q000008:administration & dosage / Q000378:metabolism; D007457:Iodine Radioisotopes; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000378:metabolism; D007700:Kinetics; D008297:Male; D004856:Postural Balance
D003287:Contrast Media; D007457:Iodine Radioisotopes; D003974:Diatrizoate Meglumine; D007451:Iodamide; D007482:Iothalamate Meglumine
Pharmakokinetik angiographischer Kontrastmittel unter besonderer Berücksichtigung des extravasalen Raumes. Eine experimentelle Grundlagenstudie an Hunden zur Charakterisierung der Angiographica. I. Mitteilung:Pharmakokinetik verschiedener Kontrastmittel unter den Bedingungen der Dauerinfusion ("Fliessgleichgewicht")