[Comparative investigations of osteotropic radionucleides. IV. The dynamics of uptake in normal and abnormal bone (author's transl)].
The dynamics of uptake of osteotropic radionucleides in normal and abnormal bone were studied by means of sequential and functional scans. Various phosphate and phosphonate complexes were compared in vivo and in vitro. Only phosphonates were considered as suitable for bone scanning. In normal bones in beagles, radioactivity after HEDP fell to 65% after two hours, but was 105% with 18F. In relation to healing fractures, the curves differ quantitatively and qualitatively. In this situation, functional curves derived from dynamic scans provide a better parallel with histological findings than does static scintigraphy with an uptake quotient. Sequential and functional scanning are able to document the therapeutic effect of irradiation of bone metastases.
D000818:Animals; D001847:Bone Diseases / Q000378:metabolism*; D001859:Bone Neoplasms / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D001943:Breast Neoplasms; D004164:Diphosphonates / Q000378:metabolism; D004285:Dogs; D005260:Female; D005461:Fluorine / Q000378:metabolism; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010710:Phosphates / Q000378:metabolism; D011471:Prostatic Neoplasms; D011542:Pseudarthrosis / Q000378:metabolism; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013324:Strontium / Q000378:metabolism; D013326:Strontium Radioisotopes; D013667:Technetium / Q000378:metabolism
D004164:Diphosphonates; D010710:Phosphates; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D005461:Fluorine; D013667:Technetium; D013324:Strontium
Vergleichende Untersuchungen mit osteotropen Radionukliden; IV. Dynamik der Anreicherung im normalen und pathologisch veränderten Knochen