title: An estimate of the recombination frequency between the B locus and the D locus within the major histocompatibility complex.
abstract: Mixed leukocyte culture studies on 120 families, including 120 HLA haplo-identical siblings and 210 HLA-identical siblings, were analyzed for unusual patterns of reactivity. Three discrepant reactions were noted in which cells from HLA-identical siblings showed strong mutual stimulation. These data provide an estimate of 0.0065 as the recombination frequency between the HLA-B and HLA-D regions of the major histocompatibility chromosome in man. When combined with the data of Keuning et al. (1975), the value is 0.0068 with a 95% confidence interval of 0.0022 to 0.0158.
mesh_terms: D003434:Crossing Over, Genetic; D005260:Female; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D009154:Mutation; D011995:Recombination, Genetic
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens