title: The influence of concentration and dose upon the extravascular distribution of intra-arterially injected meglumine diatrizoate.
abstract: The dose and concentration of an intra-arterially injected contrast medium, when increased approximately fivefold from a slightly hypotonic solution, produced lower tissue distribution volumes and lower extravascular diatrizoate fractions in the rat. A further fivefold increase in dose (to 1 ml/kg) with little change in concentration produced even lower early distribution volumes. Increases of concentration and dose caused a higher percentage of the contrast medium to remain within the vasculature, presumably as a result of extraction of tissue water by the hypertonic medium. Changes in the concentration of the contrast medium affected its distribution volume for a longer time than corresponding changes in the actual dose. The use of the more concentrated contrast media at higher doses should be expected to give better radiologic detail on angiograms.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage* / Q000378:metabolism; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage* / Q000378:metabolism; D007269:Injections, Intra-Arterial; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000378:metabolism; D013737:Testis / Q000378:metabolism
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine