The roots of bioenergetics.
Understanding metabolic energy transformation began with the realization of an 'intrusion' of phosphate into the mechanism of alcoholic fermentation. The discovery of an analogous participation of phosphate in muscle glycolysis connected the metabolic generation of energy-rich phosphate bonds fed into a common transmitter, adenosine triphosphate (ATP), with the production of mechanical energy through the finding that the phosphoryl group of creatine phosphate transferred to ATP could supply the energy for muscle contraction. In this way, a functional applicability of the energy of the phosphate bond was first shown. This observation was soon followed by the recognition that the phosphoanhydride bond of ATP provided the driving force in biosynthetic reactions; in this type of bond, metabolic energy apparently collects before it is transmitted for functional and biosynthetic use. The storage of energy in ATP was first detected in anaerobic energy-yielding reactions but soon was also found in respiratory and photosynthetic energy production. However, the mechanism by which energy derived from metabolites was converted into phosphate-bond energy in the latter processes appeared to differ from that of anaerobic energy transmission. Whereas phosphorylated compounds mediate the latter in homogeneous solutions, aerobic phosphorylation and photophosphorylation in prokaryotes seem to require special submembranous structures; and in eukaryotes, energy conversion is a function of special organelles, the mitochondria and chloroplasts. The evolutionary aspects of the transition from prokaryotes to eukaryotes are of considerable interest. In conclusion, the relevance of an apparent prokaryotic origin of the energy-transforming organelles in the eukaryotes will be commented on.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D001671:Biochemistry / Q000266:history*; D005075:Biological Evolution; D003401:Creatine / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D004734:Energy Metabolism; D005285:Fermentation; D005420:Flavoproteins / Q000378:metabolism; D005636:Fructosephosphates / Q000378:metabolism; D005988:Glyceric Acids / Q000378:metabolism; D006019:Glycolysis; D049673:History, 20th Century; D008564:Membrane Potentials; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D009119:Muscle Contraction; D015879:Myosin Subfragments / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010710:Phosphates / Q000378:metabolism; D010785:Photophosphorylation; D011725:Pyridines / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D013816:Thermodynamics
D003580:Cytochromes; D005420:Flavoproteins; D005636:Fructosephosphates; D005988:Glyceric Acids; D015879:Myosin Subfragments; D009711:Nucleotides; D010710:Phosphates; D011725:Pyridines; D011773:Pyruvates; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D003401:Creatine