[Participation of the cerebral serotonin receptors in the negative-feedback mechanisms of the hypothalamus-hypophysis-testis system].
Intraperitoneal administration of 5-oxytryptophane or the administration of serotonin into the lateral ventricle of the brain to the unilaterally castrated male albino rats was accompanied by block of the compensatory increase of the testosterone level in the peripheral blood plasma occurring after its fall caused by hemicastration. Under analogous conditions the intraperitoneal administration of p-chlorphenylalanine or the intraventricular administration of methisergide intensified the compensatory increase of blood testosterone after castration. A conclusion was drawn that stimulation of the serotonin receptors of the brain produced an inhibitory influence on the central negative feed-back mechanisms in the hypothalamus-hypophysis-testes system.
D000818:Animals; D001921:Brain / Q000502:physiology; D002369:Castration; D005246:Feedback; D010134:Fenclonine / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D011985:Receptors, Serotonin; D012701:Serotonin; D013739:Testosterone; D010134:Fenclonine; D008784:Methysergide
Ob uchastii serotoninovykh retseptorov golovnogo mozga v mekhanizmakh obratnoĭ otritsatel'noĭ sviazi sistemy gipotalamus-gipofiz-semenniki.