Development of meningeal leukemia in rats by intracerebral or intrameningeal inoculation of the acute transplantable leukemia L 5222.
An experimental model of meningeal leukemia is developed by intracerebral or intrameningeal inoculation of cells from the transplantable acute rat leukemia L 5222. The histopathological pattern is similar to that observed in central nervous system leukemia in man. The leukemia L 5222 becomes systemic 2 days after intracerebral inoculation.
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology; D005260:Female; D007942:Leukemia, Experimental / Q000473:pathology*; D008297:Male; D008578:Meninges; D008954:Models, Biological; D009368:Neoplasm Transplantation; D051381:Rats; D013120:Spinal Cord Neoplasms / Q000473:pathology; D014184:Transplantation, Homologous