Delayed-type hypersensitivity in patients with mycosis fungoides.
Cell-mediated immune reactivity was studied in 23 patients with mycosis fungoides and Sézary's syndrome by a semi-quantitative 2,4-dinitrochlorobenzene (DNCB) sensibilization test and the reaction to intracutaneous microbial antigens. Anergy to DNCB was observed in 8 patients, 5 had a markedly depressed DNCB score, 6 showed negative reactions to the microbial antigens. A defect in antigen recognition is suggested.
D000328:Adult; D000368:Aged; D000946:Antigens, Fungal; D002176:Candida albicans / Q000276:immunology; D003873:Dermatitis, Exfoliative / Q000276:immunology; D004137:Dinitrochlorobenzene; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007645:Keratoderma, Palmoplantar / Q000276:immunology; D008206:Lymphatic Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*; D012882:Skin Tests; D013577:Syndrome
D000946:Antigens, Fungal; D004137:Dinitrochlorobenzene