Trinitrotoluene: a review of reported dose-related effects providing documentation for a workplace standard.
The scientific and medical literature on TNT was reviewed with emphasis on studies providing correlation between work exposures and adverse health effects. Numerous adverse effects including upper respiratory and gastrointestinal complaints, anemia, liver function abnormalities, and possibly aplastic anemia have been noted at TNT levels below the current standard of 1.5 mg/m3. Mild biological effects, particularly reduction in hemoglobin levels or red blood cell counts, have been noted at exposures as low as 0.2 mg/m3. A workplace standard of 0.5 mg/m3 as an 8 hour time-weighted exposure is suggested for protection against adverse health effects.
D000741:Anemia, Aplastic / Q000139:chemically induced; D000818:Animals; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects; D002415:Cats; D009783:Dermatitis, Occupational / Q000209:etiology; D004285:Dogs; D004781:Environmental Exposure; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007509:Irritants / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D009784:Occupational Diseases / Q000139:chemically induced*; D011817:Rabbits; D051381:Rats; D012140:Respiratory Tract Diseases / Q000139:chemically induced; D014303:Trinitrotoluene / Q000009:adverse effects* / Q000494:pharmacology / Q000633:toxicity
D006454:Hemoglobins; D007509:Irritants; D014303:Trinitrotoluene