[Simultaneous determination of lysozyme and IgA-content in human parotid saliva, compared with flow-rate and totalprotein-secretion during rest and stimulation (author's transl)].
Parotid saliva was collected in 10-minutes-fractions during rest and stimulation from 66 healthy individuals. The time of collection was 80 minutes, in every sample flow-rate, total-protein-concentration, IgA- and Lysozyme-content were determined. According to sex and age of the individuals, the results obtained were classified in four groups. Stimulation produced characteristic changes in the flow-rates, which seemed to be correlated with the age of the persons. The total-protein-concentration of the single samples showed great differences; yet, regarding flow-rate and proteinconcentration together, the so calculated secretion of protein of every gland was almost the same. Secretion of IgA was dependent on age and sex: the secretion-rate was greater in females than in males. Besides, younger people had lower IgA-concentrations than older ones. On the other hand, lysozyme-secretion was reciprocal to IgA-secretion. The concentration of lysozyme was much higher in young persons compared with the older group. The clinical importance of this findings is discussed.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001205:Ascorbic Acid / Q000494:pharmacology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis*; D010306:Parotid Gland / Q000378:metabolism*; D011506:Proteins / Q000032:analysis*; D012146:Rest; D012463:Saliva / Q000032:analysis / Q000201:enzymology*; D012636:Secretory Rate / Q000187:drug effects; D012737:Sex Factors; D013268:Stimulation, Chemical
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D011506:Proteins; D009113:Muramidase; D001205:Ascorbic Acid
Simultanbestimmungen von Lysozym- und Immunglobulin-A-Gehalt von menschlichem Parotissekret im Vergleich zu Flussrate und Gesamtprotein-ausscheidung bei fraktionierter Ruhe-und Reizabnahme