Potassium cyanate, an in vitro inhibitor of lymphocyte blast transformation without in vivo activity.
Potassium cyanate (400 mug/ml) inhibited the blastogenesis of lymphocytes in response to PHA and the response of lymphocytes in mixed lymphocyte cultures. Cyanate administered to mice at a dose of 30 mg per kg per day did not delay allograft rejection.
D000818:Animals; D003485:Cyanates / Q000494:pharmacology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice
D003485:Cyanates; D037102:Lectins