Humoral immunity in kidney transplant recipients.
Sera obtained from kidney transplant recipients at various times after the graft were investigated for the presence of cytotoxic antibodies to B and T human lymphoid cells and for their ability to inhibit mixed lymphocyte reaction between allogeneic lymphocytes. More than 50% of sera from 35 such patients contained cytotoxic antibodies to B lymphocytes and 27 of 33 sera blocked and miced lymphocyte reaction by 25 to 75%. A statistically significant association between the presence of cytotoxic antibodies to B cells and the ability to block the mixed lymphocyte reaction was found in the group of patients with functioning grafts. However, the presence of cytotoxic antibodies to B lymphocytes did not correlate with the outcome of the graft.
D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000378:metabolism; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007106:Immune Sera / Q000032:analysis; D007109:Immunity; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D014184:Transplantation, Homologous
D007106:Immune Sera; D003165:Complement System Proteins