Ultrastructure of ovarian teratomas in LT mice.
Stem cells of these tumors formed nests consisting of undifferentiated embryonic cells in the center with more differentiated cells towards the periphery. A type viral particles were seen in the cisternae of rough endoplasmic reticulum. Ultrastructurally the stem cells of ovarian teratomas did not differ from stem cells of testicular or embryo-derived teratomas. They were however distinct from the cleavage stage embryonic cells and/or the unfertilized ovum, they stemmed from. They correspond both cytologically and developmentally to ectodermal embryonic cells from the egg-cylinder, the most advanced developmental stage of parthenotes observed previously in the ovary of LT mice.
D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006107:Granulosa Cells / Q000648:ultrastructure; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental; D009417:Nerve Tissue / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000473:pathology*; D010063:Ovum / Q000648:ultrastructure; D013724:Teratoma / Q000473:pathology*