The effect of adrenal cortical hormones on the calcium content of rat aorta.
The administration of prednisone in a dose of 10 mg/kg b.w. per os and of deoxycorticosterone in a dose of 10 mg/kg i.p. to rats weighing 200--220 g 24 hours before the experiment did not affect significantly the calcium content of the aortic vascular tissue. Metopiron, which influences biosynthesis of the adrenal hormones, likewise did not affect the calcium content when administered i.p. in a dose of 500 mg/kg b.w. and did not inhibit reserpine-induced calcium depletion. The results thus failed to confirm the hypothesis that reserpine influences the calcium content of the vascular wall via stimulation of corticold release.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000494:pharmacology; D005260:Female; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D011241:Prednisone / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013268:Stimulation, Chemical
D000305:Adrenal Cortex Hormones; D003900:Desoxycorticosterone; D012110:Reserpine; D002118:Calcium; D011241:Prednisone; D008797:Metyrapone