Studies on plasma membranes. XXIII. Hormone-like action of concanavalin A on liver plasma membranes: inhibition of (Na+-K+)ATPase.
Concanavalin A inhibits the (Na+-K+)-ATPase activity of isolated rat-liver plasma membranes, while leaving the Mg2+-ATPase unaffected. Glucagon and cyclic AMP act supplementary to the lectin in the inhibition. The lectin effect is counteracted by insulin and L-epinephrine, and is completely abolished by the beta-adrenergic blocking agent propranolol. Results are discussed on the basis of the known interactions of concanavalin A with plasma membrane components, including its hormone-like action.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D003208:Concanavalin A / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008757:Methylglucosides / Q000494:pharmacology; D008766:Methylmannosides / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D007328:Insulin; D008757:Methylglucosides; D008766:Methylmannosides; D003208:Concanavalin A; D005934:Glucagon; D011433:Propranolol; D000251:Adenosine Triphosphatases; D004837:Epinephrine