[Immunologic diagnostic pulmonary diseases caused by inhaled isocyanates (author's transl)].
Besides the strong irritative effect on the respiratory tract the isocyanates probably also have an allergenic effect. The paper gives a review of literature about immunologic in vitro- and in vivo-methods in this question. Difficulties arise especially with preparation of antigen. Isocyanates are thought to link with proteins to give antigenic conjugates. Specifity firstly depends on the isocyanate hapten.
D000818:Animals; D003485:Cyanates / Q000009:adverse effects*; D006241:Haptens; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007111:Immunity, Cellular; D009784:Occupational Diseases; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000276:immunology*
D003485:Cyanates; D006241:Haptens
Immunologische Diagnostik isozyanatbedingter Atemwegserkrankungen (Literaturübersicht).