title: [The radiological manifestations of disseminated histiocytosis X in adults (author's transl)].
abstract: The radiological findings of disseminated histiocytosis X in twelve patients (eight men, four women) aged 16 to 61 years are described. Pulmonary manifestations (eight cases) are characterised by symmetrical, bilateral involvement with predominance in the middle and upper lung fields, with relative sparing of the bases and apices. Multiple, unsharp, localised foci up to 1 cm. characterise the acute stage, "honey-combing" (multiple, uniform cysts of about 1 cm.) characterise the chronic stage. The hilar nodes are frequently somewhat enlarged. Pneumothorax (bilateral in one case) is a not uncommon complication. Skeletal involvement is often multiple (five out of seven cases) and symmetrical. Sharply defined or diffuse areas of osteolysis measuring from several millimetres to several centimetres were found in the skull, spine, ribs, pelvis and long tubular bones, sometimes with reactive sclerosis. Pathological fractures, cortical thickening, solid periostal reactions, bone expansion and central sequestra complete the radiological picture.
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005260:Female; D005598:Fractures, Spontaneous / Q000150:complications / Q000209:etiology; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D008334:Mandible; D008875:Middle Aged; D010014:Osteolysis / Q000150:complications / Q000209:etiology; D010384:Pelvic Bones; D011030:Pneumothorax / Q000150:complications / Q000209:etiology; D011859:Radiography; D012253:Rib Fractures / Q000209:etiology; D012886:Skull; D013977:Tibia
chemical_list: D000305:Adrenal Cortex Hormones
vernacular_title: Die Röntgenmanifestation der disseminierten Histiozytosis X beim Erwachsenen.