Experimental results to immunomesenchymal suppression.
Wet weight of cotton-pellet granuloma and 35SO4-uptake in the acid mucopolysaccharides (AMPS) of granulation tissue of rats and the number of plaque forming cells (PFC) of mice were investigated after the treatment with antilymphocyte globulin, prednisolone, cyclophosphamide and azathioprine. In this way, the effect of these substances could be observed in a mesenchymal reaction and in an immune reaction. The substances are mesenchymosuppressive as well as immunosuppressive, but the present results show that the effective dosage is higher for mesenchymal suppression than for immunosuppression. Antilymphocyte globulin did not cause an alteration of the 35SO4-uptake in AMPS. These experimental findings confirm the clinical experience in the treatment of the so-called autoimmunological diseases which are primary localized in connective tissue. These diseases need a higher dosage of cytostatic substances, glucocorticoids and antilymphocyte globulin in times of acute inflammatory exacerbation than in the chronic phase.
D000818:Animals; D000918:Antibody Specificity; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001379:Azathioprine / Q000494:pharmacology; D002452:Cell Count; D003520:Cyclophosphamide / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000378:metabolism; D006099:Granuloma / Q000276:immunology / Q000378:metabolism; D006462:Hemolytic Plaque Technique; D006736:Horses / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011239:Prednisolone / Q000494:pharmacology; D013045:Species Specificity; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013431:Sulfates / Q000378:metabolism
D000961:Antilymphocyte Serum; D006025:Glycosaminoglycans; D007106:Immune Sera; D007166:Immunosuppressive Agents; D013431:Sulfates; D003520:Cyclophosphamide; D011239:Prednisolone; D001379:Azathioprine