[Effect of heparin on the Mg++-ATPase of the muscle mitochondria of adult and young rabbits].
ATPase activity from freshly prepared, "aged" and "heparin" mitochondria was studied in adult, newborn and 7 day old rabbits. Heparin, incubated with the mitochondria within 2-2.5 hrs at 20 degrees C, increased the activity of endogenous ATPase in the newborn rabbits. Activities of Mg-2++-ATPase and Mg-2+-DNP-ATPase were decreased under effect of heparin in both adult and new born rabbits. In 7 day old rabbits, to the contrary, increased activity of Mg-2+-ATPase and its activation by 2,4-DNP were observed.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002413:Cations, Divalent; D004140:Dinitrophenols / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008274:Magnesium / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000201:enzymology; D011817:Rabbits
D002413:Cations, Divalent; D004140:Dinitrophenols; D006493:Heparin; D000251:Adenosine Triphosphatases; D008274:Magnesium
Vliianie geparina na Mg++-ATFazu myshechnykh mitokhondriĭ vzroslykh krolikov i krol'chat