Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.
Insulin-, glucagon-, and somatostatin-contianing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin- and glucagon-containing cells were significantly increased in the islets of juvenile-type human diabetics and of streptozotocin diabetic rats.
D000328:Adult; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D005260:Female; D005934:Glucagon; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D007328:Insulin; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D051381:Rats; D013004:Somatostatin; D013311:Streptozocin
D007328:Insulin; D013004:Somatostatin; D013311:Streptozocin; D005934:Glucagon