The carcinogenic effect of beta-oxidized dipropylnitrosamine in mice. I. Dipropylnitrosamine and methyl-propylnitrosamine.
Di-n-propylnitrosamine (DPN) and methyl-n-propylnitrosamine (MPN) induced mainly respiratory tract neoplasms in female NMRI mice after subcutaneous administration. The majority of tumors occurred in the nasal cavities, although significant incidences were also found in the larynx, trachea and stem bronchi. Treatment with both substances additionally resulted in vascular neoplasms of the liver, while DPN only caused tumors in the pharynx, esophagus and forestomach.
D000818:Animals; D001984:Bronchial Neoplasms / Q000139:chemically induced; D006224:Cricetinae; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D007822:Laryngeal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000009:adverse effects*; D009669:Nose Neoplasms / Q000139:chemically induced; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D014134:Tracheal Neoplasms / Q000139:chemically induced
D009602:Nitrosamines