Variations in the length of S-phase related to the time cells are blocked at the G1-S interface.
The inhibition of DNA synthesis with hydroxyurea or 5-fluorode-oxyuridine decreases the duration of S-phase of synchronously growing Chinese hamster cultures. - The observed drug effects are discussed in relation to an alteration of programmed DNA replication.
D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D005467:Floxuridine / Q000494:pharmacology; D006918:Hydroxyurea / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D005467:Floxuridine; D006918:Hydroxyurea