Three chromosome abnormalities (trisomy 21, XXY, and a de nova reciprocal translocation) in a child with 48, XXY, + 21,T(6;10)(P22-24;P12).
An infant with chromosomally normal parents was found to have double aneuploidy and a reciprocal translocation between chromosomes number 6 and 10. This cooccurrence may represent a very rare coincidence or may indicate that primary nondisjunction and chromosome rearrangements may be more than coincidentally related.
D002869:Chromosome Aberrations; D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007713:Klinefelter Syndrome / Q000150:complications / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic