Erythrocyte membrane cation carrier in mania.
Erythrocyte sodium and potassium concentrations, erythrocyte membrane ATPase (Na-K specific and non-specific) and the rate of potassium influx into erythrocytes (ouabain-sensitive and insensitive) were estimated in a group of female patients suffering from mania and repeated on about two thirds of them when they had recovered. With recovery there was a statistically significant increase in the erythrocyte ouabain-sensitive potassium influx. The other parameters showed no significant overall change with recovery but the initial severity correlated significantly and negatively with the change in erythrocyte Na-K ATPase with recovery. The changes that occurred in the erythorcyte sodium concentration and Na-K ATPase activity were not random since they correlated significantly with changes in the active potassium influx.
D000251:Adenosine Triphosphatases / Q000032:analysis; D001693:Biological Transport, Active; D001714:Bipolar Disorder / Q000097:blood*; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000378:metabolism*; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011188:Potassium / Q000032:analysis / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales; D012075:Remission, Spontaneous; D012964:Sodium / Q000032:analysis / Q000378:metabolism*
D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium