[Liver chalones].
Administration of a liver extract and the blood serum of adult intact mice and also of the blood serum of practically healthy persons to CBA X C57B1 hybrid mice produced a sharp depression of the mitotic activity of hepatocytes in the regenerating liver after its partial removal. The extract of the regenerating liver and the blood serum of the animals with the regenerating liver failed to depress mitoses in hepatocytes. The blood serum of man with the postnecrotic active cirrhosis of the liver not only failed to depress mitoses in the hepatocytes, but even caused an increase in their count. It is supposed that there was a reduction of the chalone concentration in the cirrhotic liver.
D000818:Animals; D003864:Depression, Chemical; D006131:Growth Inhibitors / Q000032:analysis* / Q000494:pharmacology; D006824:Hybridization, Genetic; D007106:Immune Sera / Q000494:pharmacology; D008099:Liver / Q000032:analysis*; D008103:Liver Cirrhosis / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008938:Mitosis / Q000187:drug effects
D006131:Growth Inhibitors; D007106:Immune Sera
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