title: [General pharmacology and secretion inhibitory action of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropanium bromide-(+/-)-tropate (ipratropiumbromide) (author's transl)].
abstract: (8r)-3alpha-Hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate (ipratropiumbromide, Sch 1000) is a quaternary tropic acid tropane ester with pronounced anticholinergic activities (inhibition of secretion and spasmolysis). The effect of the substance of all parasympathetically innervated organs ist 1.4 to 2 times stronger than that of atropine. As an inhibitor of the secretion of free hydrochloric acid in the stomach it proved to be 5 times more effective than atropine. Central activities were not observed. The duration of action of Sch 1000 exceeds that of atropine by far.
mesh_terms: D000818:Animals; D001286:Atropine Derivatives; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002415:Cats; D004285:Dogs; D005725:Ganglia, Autonomic / Q000187:drug effects; D005750:Gastric Juice / Q000378:metabolism; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D009241:Ipratropium / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010276:Parasympatholytics; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012472:Salivation / Q000187:drug effects; D014202:Tremor / Q000139:chemically induced
chemical_list: D001286:Atropine Derivatives; D010276:Parasympatholytics; D010095:Oxotremorine; D009241:Ipratropium
vernacular_title: Allgemeine Pharmakologie und sekretionshemmende Wirkung von (8r)-3alpha-Hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromid-(+/-)-tropat (Ipratropiumbromid)