[Endogenous prostaglandins and decrease of sensitivity to noradrenaline in the rat].
In the Rat, desensitization to noradrenaline induced by perfusion of large doses of noradrenaline (0.5 to 0.75 mug/mn/100 g), is not suppressed by indomethacine (1 to 5 mg/100 g). Synthesis and release of endogenous prostaglandins of the PGE group are not the cause of the desensitization.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D007263:Infusions, Parenteral; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology*; D011458:Prostaglandins E / Q000502:physiology; D051381:Rats; D013997:Time Factors; D014666:Vasomotor System / Q000187:drug effects
D011453:Prostaglandins; D011458:Prostaglandins E; D009638:Norepinephrine; D007213:Indomethacin
Prostaglandines endogènes et diminution de la sensibilité à la noradrénaline chez le rat