title: Susceptibilities of normal and malignant human lung cells in culture to the cytocidal action of antitumor agents.
abstract: Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, bleomycin, actinomycin D, mitomycin C, carboquone, 1-beta-D-arabinofuranosylcytosine, 5-fluorouracil, and 5-fluorodeoxyuridine. Among these, Adriamycin, 5-fluorouracil, and 5-fluoro-deoxyuridine exhibited a higher differential lethal action on the malignant cells than did the other antitumor agents. The two cell lines exhibited little difference in cytolytic sensitivity to non-antitumor cytotoxic agents such as amphotericin B, G-strophanthin, and alph-amanitin.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005467:Floxuridine / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000187:drug effects*; D008175:Lung Neoplasms / Q000188:drug therapy*; D009374:Neoplasms, Experimental / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D005467:Floxuridine; D004317:Doxorubicin; D005472:Fluorouracil