title: Synchronous reversible alterations in enzymatic activity (conformational fluctuations) in actomyosin and creatine kinase preparations.
abstract: The phenomenon of synchronism of oscillations of actomyosin and creatine kinase activity in the whole volume of the enzyme preparations was analysed. The synchronous "conformational oscillations" were observed in concentrated gels of actomyosin and in diluted actomyosin and creatine kinase solutions (ATP-creatine N-phosphotransferase, EC 2.7.3.2). The macromolecules of proteins studied may be in two or four conformational states differing enzymatic activity. Large fluctuations become possible in a range of conditions wherein two or four different states, or conformers, are equiprobable. The synchronization of conformational changes of separate macromolecules is maintained with energy derived, for instance, from some oxidative process or dilution of the solution, the process being displayed as conformational oscillations.
mesh_terms: D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D008433:Mathematics; D009132:Muscles / Q000201:enzymology; D011487:Protein Conformation; D011817:Rabbits
chemical_list: D000205:Actomyosin; D003402:Creatine Kinase; D000251:Adenosine Triphosphatases