Staphylococcal polysaccharide products inhibitory to Staphylococcus aureus bacteriophage.
Four products derived from Staphylococcus aureus cultures were partially purified and tested for inhibitory activity against staphylococcal phage. Phage inhibition, a specific stable phenomenon, was concentration dependent. All inhibitory products contained carbohydrate and amino acids, the most active (phage 73 lysate product) having a high carbohydrate content. Galactose, glucosamine, five or six amino acids, and possibly 3-O-methylglucose and a uronic acid were found as components in all active preparations. However, the exact nature of the active material remains undetermined.
D002473:Cell Wall / Q000032:analysis; D005690:Galactose / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D008757:Methylglucosides / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000032:analysis / Q000494:pharmacology*; D013204:Staphylococcus Phages / Q000187:drug effects* / Q000254:growth & development; D013211:Staphylococcus aureus / Q000032:analysis; D013237:Stereoisomerism; D014574:Uronic Acids / Q000032:analysis
D008757:Methylglucosides; D011135:Polysaccharides, Bacterial; D014574:Uronic Acids; D005944:Glucosamine; D005690:Galactose