Effect of colchicine and prednisolone upon the peptidergic neurosecretory product in Cyprinus carpio L.
After a treatment with physiological doses of colchicine and prednisolone, the rapid transport of the neurosecretory granules in the preoptico-neurohypophyseal tract of Cyprinus carpio L. is blocked. This fact is manifested by the accumulation of neurosecretory granules and of Hering's bodies at the level of fibres of preoptico-neurohypophyseal tract, and on the contrary, by the significant reduction of neurosecretory product in the nerve fibres of the neurohypophysis. The neurotubules which participate in the rapid axonal flux of neurosecretory granules do not suffer detectable ultrastructural changes.
D000818:Animals; D002347:Carps; D003078:Colchicine / Q000494:pharmacology*; D003530:Cyprinidae; D009489:Neurosecretion / Q000187:drug effects*; D010904:Pituitary Gland, Posterior / Q000187:drug effects*; D011239:Prednisolone / Q000494:pharmacology*
D011239:Prednisolone; D003078:Colchicine