Effect of biogenic amines and GABA on ATPase activities in mouse tissue.
ATPase activities were studied in brain, kidney and liver (13,000 X g pellet) fraction from the mouse. Dopamine and norepinephrine added in vitro showed a dose-dependent stimulation of Na+ and K+ activated and oligomycin sensitive Mg2+ ATPase activities in brain but not kidney and liver tissue fractions. GABA and serotonin had no effect on ATPase in brain, but inhibited oligomycin sensitive Mg2+ ATPase activities in kidney and liver. The relationship between the enhancement of ATPase activity by neurotransmitters in brain and the neuronal excitation is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D001921:Brain / Q000648:ultrastructure; D004298:Dopamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000494:pharmacology; D009840:Oligomycins / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013347:Subcellular Fractions / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D001679:Biogenic Amines; D009840:Oligomycins; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D000251:Adenosine Triphosphatases; D004298:Dopamine; D009638:Norepinephrine