[Study on the mode of action of dithranol: increased lipid peroxidation and enzyme inhibition].
The results reported in connection with previously published data suggest the importance of increased lipid peroxidation in the epidermis after Dithranol treatment. Malonaldehyde, one of the main products of lipid peroxidation, reacts with epidermal phosphofructokinase and glucose-6-phosphate dehydrogenase to cause enzyme inactivation by cross-linking of the enzyme protein demonstrated by dodecyl sulphate electrophoresis. Enzyme inactivation leads to an inhibition of hexose monophosphate shunt and glycolysis. The effect on energy donating metabolism in psoriatic lesions is discussed.
D000873:Anthracenes / Q000494:pharmacology*; D000875:Anthralin / Q000494:pharmacology*; D003429:Cross Reactions / Q000187:drug effects; D003864:Depression, Chemical; D004794:Enzyme Repression; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism; D010732:Phosphofructokinase-1 / Q000378:metabolism; D012867:Skin / Q000201:enzymology / Q000378:metabolism*; D013268:Stimulation, Chemical
D000873:Anthracenes; D005954:Glucosephosphate Dehydrogenase; D010732:Phosphofructokinase-1; D000875:Anthralin
Untersuchungen zum Wirkungsmechanismus von Dithranol: Erhöhte lipidperoxydation und Enzymhemmung