title: Acne vulgaris: double-blind trial comparing tetracycline and clindamycin.
abstract: A double-blind prospective study was undertaken to compare low-dosage tetracycline hydrochloride and clindamycin hydrate hydrochloride in the treatment of patients with pustular acne. Clinical improvement was noted in 93.7% of those receiving tetracycline and in 92.8% of those receiving clindamycin. Of those patients who were receiving clindamycin, two patients developed diarrhea and one patient developed pseudomembranous colitis. We conclude, therefore, that clindamycin should not be used as a primary drug in the treatment of acne.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002981:Clindamycin / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003109:Colonic Diseases, Functional / Q000139:chemically induced; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012075:Remission, Spontaneous; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D002981:Clindamycin; D013752:Tetracycline