[In vitro distinction between primary and secondary cellular response to alloantigens by means of a subcellular antigenic preparation].
Living spleen cells and a subcellular product of spleen cells have been compared, in mice, for their ability to elicit, for a long term culture (4-5 days), a cellular cytotoxic response against alloantigens. Contrary to living spleen cells which could induce the same high level of cytotoxic activity in a primary or in a secondary response, the antigenic preparation was only able to mount a very low primary response while it could render highly cytotoxic a lymphoid population proved to be able to mount in vitro an anamnestic response.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D007156:Immunologic Memory; D066298:In Vitro Techniques; D008221:Lymphoid Tissue / Q000276:immunology; D051379:Mice; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D013347:Subcellular Fractions / Q000276:immunology; D014184:Transplantation, Homologous
Distinction in vitro des réponses cellulaires primaire et secondaire contre les alloantigènes au moyen d'une préparation antigénique subcellulaire