[The diagnostic value of enzymes in cerebrospinal fluid (author's transl)].
The clinical value of enzyme activities in cerebrospinal fluid (CSF) should be proved by examination of GOT, GPT, LDH and CPK in blood and CSF of 115 unselected and 4 selected patients. Only the GOT showed a significant correlated increase in diffuse vascular diseases in both, serum and CSF. Discussing the literature the authors affirm, that only mechanical or functional lesion of the blood-brain-barrier will increase the enzyme activities in serum and CSF. The origin of these enzymes however is unknown till now.
D000410:Alanine Transaminase / Q000097:blood / Q000134:cerebrospinal fluid; D001219:Aspartate Aminotransferases / Q000097:blood / Q000134:cerebrospinal fluid; D001416:Back Pain / Q000201:enzymology; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000201:enzymology; D002493:Central Nervous System Diseases / Q000201:enzymology*; D002555:Cerebrospinal Fluid / Q000201:enzymology*; D002561:Cerebrovascular Disorders / Q000201:enzymology; D002908:Chronic Disease; D003402:Creatine Kinase / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000134:cerebrospinal fluid; D008107:Liver Diseases / Q000201:enzymology; D008590:Meningoencephalitis / Q000201:enzymology; D009103:Multiple Sclerosis / Q000201:enzymology; D009136:Muscular Dystrophies / Q000201:enzymology
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase
Der diagnostische Wert von Enzymbestimmungen im Liquor cerebrospinalis