title: Effect of substrate pretreatment on renal organic ion transport in the adult rat.
abstract: The ability of renal cortical slices to accumulate PAH and NMN was not significantly affected by pretreatment of adult rats with large doses of PAH. Pretreatment of adult rats with THAM significantly increased PAH accumulation but had no effect on NMN. Inulin and PAH clearance and filtration fraction were significantly decreased by PAH pretreatment but unaffected by THAM pretreatment. The effects of pretreatment on transport are probably due to non-specific toxicity.
mesh_terms: D000618:Aminohippuric Acids / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007444:Inulin / Q000378:metabolism; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D014325:Tromethamine / Q000378:metabolism / Q000494:pharmacology*; D010130:p-Aminohippuric Acid / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000618:Aminohippuric Acids; D014325:Tromethamine; D009536:Niacinamide; D007444:Inulin; D010130:p-Aminohippuric Acid