[Trypsin-induced polyseritis: action of di-iso-propyl-fluorophosphate; evolution of the proteas activity of effusion; comparison with elastase].
1. Whereas the injections of trypsin in the peritoneum of the rat cause every time a polyseritis (ascites and pleuritis) the trypsin inactivated by di-iso-propyl-fluoro-phosphate remains without effect; this fact proves therefore that the proteasic properties of the trypsin are responsible of this exsudative effect on peritoneum and pleura. 2. The intra-peritoneal injections of elastase cause also a polyseritis in the rat, but it is complicated by shock. 3. The dosage of the proteasic activity in the effusions caused by the trypsin and the elastase, shows a progressive reduction of this activity. At the beginning there is more protease in the ascites than in pleural serositis and the volume of the ascites is greater; later, the findings about the proteases are opposite and the protease content becomes greater in the pleural effusion. This evolution is a new proof of the transdiaphragmatic propagation of the proteasic polyseritis.
D000818:Animals; D001201:Ascites / Q000139:chemically induced*; D001202:Ascitic Fluid / Q000032:analysis; D007531:Isoflurophate / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000032:analysis / Q000378:metabolism; D010447:Peptide Hydrolases / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D010996:Pleural Effusion / Q000032:analysis; D010998:Pleurisy / Q000139:chemically induced*; D051381:Rats; D014357:Trypsin / Q000032:analysis / Q000494:pharmacology*; D014361:Trypsin Inhibitors
D014361:Trypsin Inhibitors; D007531:Isoflurophate; D010447:Peptide Hydrolases; D010196:Pancreatic Elastase; D014357:Trypsin
La polysérite induite par la trypsine: action du di-iso-propyl-fluorophosphate; évolution de l'activité protéasique des épanchements; comparaison avec l'élastase