[Demonstration of pineal gland and pituitary involution in mice poisoned with carbon tetrachloride].
Ingestion of carbone tetrachloride by male C3H Orleans mice determines an involution of the pineal gland and of the hypophysis, as well as extensive lesions of the hepatic parenchyma. There may exist in these animals a higher blood-level of glucocorticoids, as this has been shown to be the case in men suffering from cirrhosis or hepatitis. Involution of the pineal gland in cases of stress, as has been shown by various authors, would result from an entirely different mechanism, that is by increased secretion of corticoadrenal hormones.
D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D002467:Cell Nucleus / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010870:Pineal Gland / Q000187:drug effects* / Q000473:pathology; D010902:Pituitary Gland / Q000187:drug effects* / Q000473:pathology; D013495:Supraoptic Nucleus / Q000187:drug effects
D000305:Adrenal Cortex Hormones
Mise en évidence d'une involution de la glande pinéale et de l'hypophyse chez des souris intoxiquées au tétrachlorure de carbone.