Effect of thyroxine administration to the mother on postnatal radioiodine uptake by the thyroid of partially thyroidectomized rats.
The experiment was carried out on 35 litters of infant rats aged 4-17 days. The animals in each litter were always divided into two groups: control (sham operation) and experimental (hemithyroidectomy). Starting with the day on which the young were operated on, the mothers received daily subcutaneous injections of either saline or of thyroxine in doses of 50, 100 or 200 mug. At the end of the experiment, the young were injected intraperitoneally with 1 muCi 131I. One hour later they were decapitated and the radioactivity in their thyroid was expressed as the percentage of the administered dose per mg thyroid. The following age groups were used, according to the interval between thyroidectomy and decapitation: 4 to 8, 9 to 13, 13 to 15 and 15 to 17 days. 131I uptake by the residue of the thyroid in partially thyroidectomized animals was always compared with the values in the animals from the same litter subjected to sham operation. The results showed that partial thyroidectomy significantly stimulated 131I uptake in all age groups in which the mother was only given saline. In the 4- to 8-day-old group, the administration of 50 or 100 mug thyroxine to the mother inhibited this compensatory increase. In the 9- to 13-day-old group, inhibition occurred only after a dose of 100 mug thyroxine. In animals with an interval from the 13th to the 15th days old the dose of thyroxine administered to the mother had to be raised to 200 mug/day to achieve an inhibitory effect. In the last group (interval 15th to 17th day), not even administration of the maximum thyroxine dose to the mother from the 13th postnatal day succeeded in inhibiting the significant increase in 131I uptake. These results show that thyroxine administered to lactating female rats can be transmitted via the milk to the organism of the young in amounts which can be demonstrated in a physiological tests.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D013965:Thyroidectomy; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*
D007457:Iodine Radioisotopes; D013974:Thyroxine