In vitro reactivity in allograft tolerance: persistence of mixed leukocyte culture reactivity in highly tolerant rats.
Mixed leukocyte culture reactivity was studied in adult W/Fu rats judged to be highly tolerant after the inoculation of (W/Fu X BN)F1 hybrid spleen and bone marrow cells at birth. Reactivity was observed in a majority of tolerant donors tested and documented by quantitative dose-response and kinetic studies. Allograft tolerance cannot be explained by a complete lack of specific immune reactivity to tolerated alloantigens.
D000818:Animals; D000831:Animals, Newborn; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D007108:Immune Tolerance; D007959:Lymphocyte Culture Test, Mixed; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D013154:Spleen / Q000637:transplantation*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous