[The treatment, by imipramine, of the hemodynamic, functional and biochemical consequences of an experimental cranio-cervical trauma in rats].
The experimental reproduction of a cranio-cervical traumatism in the rat and consecutive troubles prove the organicity of the post-concussional syndrom. This syndrom seems to be due to an acceleration of the catabolism of cerebral norepinephrin, and the treatment by imipramine seems to inhibit the decrease of its rate.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D004576:Electromyography; D005260:Female; D006339:Heart Rate; D007099:Imipramine / Q000627:therapeutic use*; D009638:Norepinephrine / Q000378:metabolism; D011187:Posture; D051381:Rats; D013124:Spinal Injuries / Q000188:drug therapy* / Q000503:physiopathology
D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine
Traitement, par l'imipramine, des conséquences hémodynamiques, fonctionnelles et biochimiques d'un traumatisme cranio-cervical expérimental chez le rat