title: Adverse reactions to co-trimoxazole in hospitalized medical patients.
abstract: Of 29,524 hospitalized medical patients monitored in a drug surveillance program, 649 (2.2%) received the fixed dose combination of trimethoprim-sulfamethoxazole, co-trimoxazole. Adverse effects of this drug occurred in 8% of recipients, the most frequent being skin rashes which occurred in 23 patients (3.5%) and upper gastrointestinal upsets which occurred in 22 (3.4%). Reactions frequently occurred within 72 hours of starting the drug and promptly resolved on stopping it. No patient experienced severe or life-threatening adverse effects. Adverse effects were unrelated to age, weight, duration of hospitalization or presenting blood urea nitrogen concentration, but were significantly commoner in female recipients.
mesh_terms: D000328:Adult; D000368:Aged; D001900:Boston; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*
chemical_list: D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole