[The effect of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate ((ipratropiumbromide) on tracheobronchial spasm, bronchial and salivary secretions, ECG and heart rate (author's transl)].
At very low doses (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate (ipratropiumbromide, Sch 1000, Atrovent) and atropine inhibit acetylcholine-induced bronchospasms in guinea-pigs and dogs. The dose ratio main effect vs. most sensitive side effect (inhibition of saliva secretion) is 1:10 for i.v. injection and 1:100 for aerosol application. When both compounds are administered in a nebulized form bronchodilatation occurs immediately. The maximum effect of Sch 1000 occurs somewhat later than that of atropine but the duration of action is much longer. Bronchial secretion in guinea-pigs is increased by small doses of Sch 1000 and atropine. These doses correspond to bronchodilating doses.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000336:Aerosols; D000818:Animals; D001286:Atropine Derivatives; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000378:metabolism*; D001986:Bronchial Spasm / Q000188:drug therapy*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D009241:Ipratropium / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D012472:Salivation / Q000187:drug effects*
D000336:Aerosols; D001286:Atropine Derivatives; D009241:Ipratropium; D000109:Acetylcholine
Wirkung von (8r)-3alpha-Hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromid-(+/-)-tropat (Ipratropiumbromid) auf Spasmen des Tracheobronchialbaumes und die Bronchialsekretion, die Speichelsekretion, EKG und Herzfrequenz