Pyrogen fever in rabbits pretreated with p-chlorophenylalanine or 5, 6-dihydroxytryptamine.
The hyperthermic effect of a bacterial pyrogen has been studied in rabbits pretreated or not with p-chlorophenylalanine or 5, 6-dihydroxytryptamine. The results obtained indicate that a selective reduction of cerebral 5-hydroxytryptamine levels by these drugs do not significantly affect pyrogen hypertermia.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D010134:Fenclonine / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism; D014363:Tryptamines / Q000494:pharmacology*
D011749:Pyrogens; D014363:Tryptamines; D012701:Serotonin; D010134:Fenclonine; D004298:Dopamine; D015115:5,6-Dihydroxytryptamine; D009638:Norepinephrine