title: Malignant hyperthermia syndrome--evidence for denervation changes in human skeletal muscle.
abstract: The presence of denervation-like changes and abnormal mitochondria in the muscle of carriers of the malignant hyperthermia syndrome suggest a neuropathic basis for the human syndrome. A defect in mitochondrial ATP synthesis resulting from denervation, and potentiated by some general anaesthetics, may be the primary muscle fibre lesion in the human malignant hyperthermic syndrome.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D006801:Humans; D008305:Malignant Hyperthermia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009132:Muscles / Q000648:ultrastructure*; D009218:Myosins / Q000378:metabolism; D009468:Neuromuscular Diseases; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
chemical_list: D000251:Adenosine Triphosphatases; D009218:Myosins; D002118:Calcium