[Tissue specific effect of lymphocytic chalone isolated from rat spleen].
Chalone-containing alcohol extract from the rat spleen consisting of 8--10 substances of protein nature, according to the data of the disk electrophoresis, possesses a selective property to inhibit the entrance of human transformed lymphocytes into the phase of DNA synthesis. Injection of lymphocytic chalones to the mice allotransplants of a donor's skin grafts, which differ from the recipient by a strong antigen, temporally delays the rejection of the transplanted graft. In mice-recipients, the thymus treated with lymphocytic chalone is characterized by the depletion of the cortical substance.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D006084:Graft Rejection / Q000187:drug effects; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D016038:Skin Transplantation; D013154:Spleen / Q000032:analysis*; D013950:Thymus Gland / Q000187:drug effects; D014018:Tissue Distribution; D014184:Transplantation, Homologous
D006131:Growth Inhibitors; D004247:DNA
K voprosu o tkanespetsificheskom deĭstvii limfotsitarnogo keĭlona, vydelennogo iz selezenki krys.