title: [Combination of novoimanine with antibiotics with a different mechanism of action].
abstract: Ampicillin, kanamycin, fusidic acid and rifocin significantly increased the effect of novoimanin on Staph. aureus 209. Histon F1 and spectinomycin did not influence the effect of novoimanin. Inefficiency of novoimanin combination with histon F1 provided a supposition that their effect may be directed to the same cell structures and most probably to the membranes. This was confirmed by the data of electron microscopy. The most effective combinations were recommended for the studies on their possible clinical use.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D004357:Drug Synergism; D005672:Fusidic Acid / Q000494:pharmacology; D006657:Histones / Q000494:pharmacology; D007612:Kanamycin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D012293:Rifampin / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D006657:Histones; D010936:Plant Extracts; D007612:Kanamycin; D005672:Fusidic Acid; D000667:Ampicillin; D000198:Spectinomycin; D012293:Rifampin
vernacular_title: Sochetanie novoimanina s antibiotikami razlichnogo mekhanizma deĭstviia