[Action of difluorodichloromethane (FC 12) and of adrenaline on the isolated rabbit heart].
Does difluorodichloromethane (FC 12) sensitize the cardiac muscle in vitro to epinephrine-induced arrhythmia ? We have tried to answer this question by comparing : the action of epinephrine alone on the isolated rabbit heart perfused by an ordinary nutritive solution  and the action of epinephrine on the heart perfused by a nutritive solution containing various concentrations of FC 12. The results are: 1) the general action of epinephrine (inotropic and chronotropic positive effects, increase of coronary flow) is not significantly modified by the action of FC 12. 2) FC 12 does not sensitize the rabbit heart in vitro to the arrhythmogenic action of epinephrine. The few cases of arrthymia recorded under the action of adrenalin do not necessarily occur in the presence of FC 12, but rather depend on the weakened state of the preparation.
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology*; D005466:Fluorocarbons / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D008752:Methylene Chloride / Q000031:analogs & derivatives* / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits
D005466:Fluorocarbons; D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride; D004837:Epinephrine
De l'action du difluorodichlorométhane (FC 12) et de l'adrénaline sur le coeur isolé de Lapin