The maturation of reticulocytes. II. Life-span of red cells originating from stress reticulocytes.
Life-spans of macroreticuloytes and macrocytic red cells were studied. Rabbits were made anemic by injecting phenylhydrazine. Peripheral blood rich in reticulocytes was drawn, labeled with 3H-amino acids, and injected back into the anemic animal. Autoradiographic observation on circulating red cells revealed that macroreticulocytes matured at nearly the same time as normal-sized reticulocytes but that the macrocytic red cells had a short life-span compared to normal-sized red cells.
D000748:Anemia, Macrocytic / Q000097:blood / Q000139:chemically induced; D000818:Animals; D001803:Blood Transfusion; D004905:Erythrocyte Aging; D008297:Male; D010659:Phenylhydrazines; D011817:Rabbits; D012156:Reticulocytes; D013997:Time Factors
D010659:Phenylhydrazines