Experimental protein-losing gastroenteropathy: role of tissue plasminogen activator.
The tissue fibrinolytic activity of intestinal mucosa was studied in rats with protein-losing gastroenteropathies experimentally produced by X-irradiation, 5-fluorouracil treatment, or ligation of the thoracic duct. The first two models showed an increase of fibrinolytic activity and of 131I-polyvinylpyrrolidone excretion and the third showed normal fibrinolysis. In addition, it was demonstrated that 131I-polyvinylpyrrolidone excretion in the first two groups was markedly reduced by injections of trans-4-aminomethyl cyclohexane carboxylic acid, a potent antiplasmin agent. This finding affords strong support to the authors' previous clinical observation that tissue fibrinolysis in the digestive mucosa plays an important role in the pathogenesis of protein-losing gastroenteropathy associated with diseases of the mucosa.
D000818:Animals; D005341:Fibrinolysin / Q000502:physiology*; D005342:Fibrinolysis / Q000187:drug effects / Q000528:radiation effects; D005472:Fluorouracil / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000503:physiopathology*; D008026:Ligation; D008297:Male; D011205:Povidone / Q000494:pharmacology; D011504:Protein-Losing Enteropathies / Q000209:etiology*; D011830:Radiation Effects; D051381:Rats; D013897:Thoracic Duct / Q000601:surgery; D014965:X-Rays
D005341:Fibrinolysin; D011205:Povidone; D005472:Fluorouracil