title: [Incapacity of 5-hydroxytryptophan to act against the depression of tumor-resisting power of host animal which is induced by whole body x-irradiation].
abstract: The effect of L-5-hydroxytryptophan (L-5-HTP) against the depression of tumor-resisting power in host animal, which is induced by a whole body x-irradiation of 500 R, was studied. Host animal and tumor cell used were LAF, hybrid mouse and mastocytoma cell, respectively. The i.p. injected dose of L-5-HTP was 6.25 mg per mouse, which is most effective for protecting mice from radiation-induced hematopoietic death. In the experimental conditions, the agent was not effective to prevent the radiation-induced depression of tumor-resisting power of the animal.
mesh_terms: D006916:5-Hydroxytryptophan / Q000378:metabolism / Q000627:therapeutic use*; D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D012515:Mast-Cell Sarcoma / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced; D014965:X-Rays
chemical_list: D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan
vernacular_title: Incapacité du 5-hydroxytrypotphanne d'agir contre la dépression du pouvoir antitumoral de l'animal-hôte induite par une irradiation corporelle totale par les rayons X