[The concentration of electrolytes and water in the walls of the frog gall bladder following absorption of an isotonic fluid].
In experiments on isolated gall-bladders (GB) of frogs, the transport rate of NaCl-isotonic solution by GB epithelial cells was inversely proportionate to the sodium content in them. Under oxytocin action (20 mE/ml) the absorption was inhibited and simultaneously the intracellular sodium content increased. Replacement of NaCl by sucrose solution caused a complete inhibition of absorption for 5--15 min. During this time, tissue cells excreted a considerable amount of their sodium, in result of which the intracellular amount of sodium decrease by 2.0-2.5 times. Oxytocin caused the inhibition of both the sodium transport from cells and the Na-K--ATPase activity. Obviously, the inhibitory action of oxytocin upon sodium transport from GB cells is due to a decrease of the transport activity of Na, K--ATPase under the action of hormone.
D000042:Absorption; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D005704:Gallbladder / Q000187:drug effects / Q000378:metabolism*; D010121:Oxytocin / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012965:Sodium Chloride / Q000378:metabolism*; D013395:Sucrose / Q000378:metabolism
D012965:Sodium Chloride; D010121:Oxytocin; D013395:Sucrose; D000251:Adenosine Triphosphatases; D011188:Potassium
Soderzhanie élektrolitov i vody v stenke zhelchnogo puzyria liagushki pri vsasyvanii izotonicheskoĭ zhidkosti