[New coordinates in the pathogenesis of poststreptococcal nephropathies].
With reference to recently published data and the authors findings, the pathogeny and prophylaxis of streptococcal nephropathy is discussed from the viewpoint of streptococcal nephritogenicity, the reactive potential of the body and the efficiency of the antibiotic treatment. It is evident that extensive prevention with penicillin is imperfect since nephropathy, in the course of its development, is subordinated to the reactogenic immunopathological context rather than to the etiologic agent (which only becomes a link in the causattion of the disease). Today, the arguments appear to sustain a new preventive stage in which prolonged, exhaustive antibiotherapy is replaced by a differentiated etiopathogenic context, applied only in the cases of actual risk and delimited by a constant intra-and postinfectious complex clinicobiologic follow up. However, the various pathogenetic coordinates show that poststreptococcal complications demand separation of the cause which may cover the actual determining factors of the complications.
D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology; D013290:Streptococcal Infections / Q000150:complications*
Noi coordonate in patogenia nefropatiei poststreptococice