title: Acne detergicans.
abstract: Popular brands of soaps and shampoos were assayed for comedogenicity in the rabbit ear. Only a small number produced hyperkeratosis when applied at a 25% concentration. Bacteriostatic substances, especially hexachlorophene, were mildly comedogenic. Conventional soaps include salts of fatty acids; the latter are known comedogens. The obsessive use of soaps by patients with acne vulgaris may aggravate the disease and result in its extension to unusual locations.
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001681:Biological Assay; D002224:Carbanilides; D003033:Coal Tar; D003902:Detergents / Q000009:adverse effects*; D005227:Fatty Acids; D006582:Hexachlorophene; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010636:Phenols; D011817:Rabbits; D012915:Soaps
chemical_list: D002224:Carbanilides; D003902:Detergents; D005227:Fatty Acids; D010636:Phenols; D012915:Soaps; D003033:Coal Tar; D006582:Hexachlorophene