[Liver extract effect on liver microsomal system and on an experimental model of intoxication].
A lyophilized liver extract (FLR) lengthens hexobarbital action in control rats ; it decreases slightly the induction of hepatic microsomal enzymes and normalizes diphenylhydantoin protection against electroshock seizure in phenobarbital-treated animals ; in the event of a CC14 intoxication, this extract reestablishes values close to normal for mebubarbital metabolism in mice and for BSP clearance in rats. FLR could act in regularizing drug metabolism.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D008110:Liver Extracts / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects
D008110:Liver Extracts; D006591:Hexobarbital; D010634:Phenobarbital
Effet d'un extrait de foie sur le système microsomal hépatique et sur un modèle d'intoxication expérimentale.