[Role of the striatum in the influence of serotoninergic substances on the course of corazole seizures in rats].
The effect of 5-oxytryptophane (5-OT) and of parachlor-phenylalanine (pCPA) on the behaviouristic EEG manifestations of metrazol convulsions in electrostimulation and destruction of the striatum was studied. The effect of the preparations on the myoclonia and the spike-wave rhythm caused by metrazol did not largely depend on the functional condition of the corpus striatum. The capacity of 5-OT to facilitate, and of pCPA to aggravate the course of generalized convulsions and of the postconvulsive state became enhanced in stimulation and was eliminated after the destruction of the striatum.
D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D000818:Animals; D003342:Corpus Striatum / Q000503:physiopathology*; D005260:Female; D010134:Fenclonine / Q000627:therapeutic use*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
D006916:5-Hydroxytryptophan; D010134:Fenclonine; D010433:Pentylenetetrazole
O roli striatuma vo vliianii serotoninergicheskikh veshchestv na techenie korazolovykh sudorog u krys