The influence of catecholamines and serotonin on histamine uptake and metabolism by guinea pig atrium.
The influence of serotonin and catecholamines on the uptake and metabolism of 14C-histamine by isolated guinea pig atrium has been investigated. Epinephrine, norepinephrine and serotonin were found to reduce the histamine uptake and the formation of methylhistamine, in a dose-dependent fashion. The order of potency was epinephrine greater than norepinephrine greater than serotonin. Aliphatic diamines, such as spermine, do not affect the accumulation and metabolism of histamine. It is suggested that serotonin and catecholamines, may enhance histamine responses by decreasing the uptake and metabolism of this amine.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*; D013096:Spermine / Q000494:pharmacology
D002395:Catecholamines; D009536:Niacinamide; D013096:Spermine; D012701:Serotonin; D006632:Histamine; D009638:Norepinephrine; D004837:Epinephrine