[Effect of various metabolic poisons on the nature of contraction of the straight muscle of the abdomen of frog].
A slow decline of responses was obtained after acetylcholine and KCl-stimulation of musculus rectus abdominis of the lake frog in the presence of antymicin A (0.27 mcg/ml). Dinitrophenol (up to 6.7.10(-4) M) as well as antymicin A inhibited the muscle contractility, with the effect being reversible. Muscle contraction ensued the application of dinitrophenol in concentration more than 6.7.10(-4)M. Decurarization ability of dinitrophenol was established. Mechanisms of disruption of the excitation--contraction coupling due to metabolic inhibitors are discussed.
D000009:Abdominal Muscles / Q000187:drug effects; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000968:Antimycin A / Q000494:pharmacology*; D001001:Anura; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000494:pharmacology*; D004336:Drug Antagonism; D009119:Muscle Contraction / Q000187:drug effects*; D011898:Ranidae; D012965:Sodium Chloride / Q000494:pharmacology; D013268:Stimulation, Chemical
D004140:Dinitrophenols; D012965:Sodium Chloride; D000968:Antimycin A; D000109:Acetylcholine
Vliianie nekotorykh metabolischeskikh iadov na kharakter sokrashcheniia priamoĭ myshtsy zhivota liagushki.