The anti-inflammatory actions of tilorone hydrochloride.
Tilorone suppressed inflammation induced by immune (direct passive Arthus reaction) as well as by non-immune agents (carrageenam-induced paw edema and abscess formation), if the compound is given 24 hr prior to the proinflammatory agonists. The non-immune anti-inflammatory effect is independent of the adrenals. A surprising findings was that total serum hemolytic complement is markedly elevated 24 hr after a single dose of tilorone.
D000038:Abscess / Q000139:chemically induced; D000284:Administration, Oral; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D001183:Arthus Reaction / Q000276:immunology; D002351:Carrageenan / Q000008:administration & dosage; D003165:Complement System Proteins / Q000032:analysis; D004487:Edema / Q000139:chemically induced; D005260:Female; D005449:Fluorenes / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D010653:Phenylbutazone / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013994:Tilorone / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D005449:Fluorenes; D002351:Carrageenan; D003165:Complement System Proteins; D010653:Phenylbutazone; D013994:Tilorone; D006854:Hydrocortisone; D007213:Indomethacin