[Effect of an extract of mouse Ehrlich ascitic tumor cells on mitotic activity and DNA synthesis in that tumor].
The extract of Ehrlich's ascitis tumour cells depressed specifically the proliferative activity of this tumour cells. This was expressed in a marked reduction in the number of dividing and DNA-synthesizing cells after the extract injection. The mitotic index fell considerably as soon as 2 hours after the injection, reached the minimum in 4 to 5 hours and was restored to the control level in 9 to 12 hours. The radioactive index appeared to be evenly decreased in the course of 18 hours of the experiment.
D000818:Animals; D001345:Autoradiography; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism; D051379:Mice; D008938:Mitosis
D004273:DNA, Neoplasm; D006131:Growth Inhibitors
Deĭstvie ékstrakta kletok astsitnoĭ opukholi Erlikha mysheĭ na mitoticheskuiu aktivnost' i sintez DNK v étoĭ opukholi.