[Toxicological studies on ipratropiumbromide (author's transl)].
The acute, subacute and chronic toxicity of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide (ipratropiumbromide, Sch 1000, Atrovent) was studied on mice, rats, dogs and monkeys following oral, s.c., i.v. administration and inhalation. With toxic doses all typical symptoms of atropine or atropine derivatives were present, like mydriasis, dryness of the mucosa and meteorism with coprostasis. It was not possible to determine the LC50 of the substance due to its low toxicity.
D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D001286:Atropine Derivatives; D004285:Dogs; D005260:Female; D000882:Haplorhini; D007267:Injections; D009241:Ipratropium / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D051381:Rats; D013997:Time Factors
D000336:Aerosols; D001286:Atropine Derivatives; D009241:Ipratropium
Toxikologische Untersuchungen mit Ipratropiumbromid