Spontaneous occurrence of delayed hypersensitivity to DNA in old NZB mice.
The sensitivity of NZB/Bl and NZB/Swiss Fl hybride mice spleen lymphocytes to DNA was examined using the MIF production and inhibition of migration from artificial fragment. The positivity was found in the group of old mice which was considered as an indication of spontaneous autoimmune process. The possible mechanism of this process is discussed.
D000375:Aging; D000818:Animals; D002464:Cell Migration Inhibition; D004247:DNA / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D051379:Mice; D008814:Mice, Inbred NZB; D013997:Time Factors
D008263:Macrophage Migration-Inhibitory Factors; D004247:DNA