Control of rat mammary-gland pyruvate dehydrogenase by insulin and prolactin.
Withdrawal of prolactin or of insulin from the circulation of lactating rats leads, within 3h, to increased inactivation by phosphorylation of mammary-gland pyruvate dehydrogenase. Prolactin may act by priming the tissue to respond directly to normal concentrations of circulating insulin and by this means be responsible for the increased activation of the enzyme during the course of normal lactation.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001971:Bromocriptine / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D007774:Lactation / Q000187:drug effects; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000201:enzymology*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D011768:Pyruvate Dehydrogenase Complex / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D001971:Bromocriptine; D013311:Streptozocin; D011388:Prolactin; D006854:Hydrocortisone