A gentamycin resistance plasmid in Staphylococcus aureus.
Drug resistance in Staphylococcus aureus is frequently mediated by non-chromosomal DNA molecules referred to as R plasmids. So far, resistance to aminosidic antibiotics was observed with streptomycin [8] and kanamycin-neomycin [3]. Resistance to gentamycin has not been reported in a recent survey by Lacey [7]. In this paper, we describe a strain of S. aureus resistant to gentamycin-kanamycin-tobramycin-sisomycin, and experiments which suggest that the genetic determinant of these resistance characters is plasmid borne.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005111:Extrachromosomal Inheritance / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology*; D007612:Kanamycin / Q000494:pharmacology; D010957:Plasmids / Q000187:drug effects*; D013204:Staphylococcus Phages; D013211:Staphylococcus aureus / Q000187:drug effects*; D014161:Transduction, Genetic
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin