Effect of amphotericin B on the incorporation of neocarzinostatin into human gastric cancerous tissues.
AmB/NCS combination therapy against cancer was evaluated. Seven gastric cancer and 2 gastric polyp cases were treated in this manner and in addition 2 gastric cancer patients were treated with NCS alone, to serve as the control. AmB dissolved in glucose solution was administered intravenously as was NCS, which was given at the onset of gastric surgery. Lesion tissues and healthy tissues were collected from each patient and the NCS titers measured by bioassay. It was shown in the majority of the gastric cancer cases that the NCS levels in the lesion tissues were substantially higher than in the surrounding normal tissues, whereas in the gastric polyp and the gastric cancer patients who received NCS alone, no significant differences were found between the tissues.
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism*; D009353:Zinostatin / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D000666:Amphotericin B; D009353:Zinostatin