[Pharmacological analysis of the peristalsis block induced by magnesium applied at the serosal and mucosal surfaces of the isolated guinea pig ileum].
Acetylcholine, metacholine, eserine and neostigmine, acting from the serosal surface antagonised the peristaltic block produced by mucosal application of magnesium, as well as when choline esters and anticholinesterases were injected intraluminally and magnesium acted from the serosal side of the guinea-pig isolated ileum. On the other hand, 5-hydroxytryptamine and histamine did not remove the peristaltic block produced by magnesium. It is concluded that cholinoceptive sites within the myenteric plexus which, when stimulated by cholinergic substanced, produce regular peristaltic waves, are accessible from either sides of the guinea-pig isolated ileum.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D009388:Neostigmine; D006632:Histamine; D010830:Physostigmine; D008274:Magnesium; D002794:Choline; D000109:Acetylcholine
Analyse pharmacologique du blocage du péristaltisme produit par le magnésium appliqué sur la séreuse et sur le muqueuse de l'iléon isolé de cobaye.