[Implantation defect in the mouse treated by WR 1339 triton: study after transplantation of ova].
Doses of 600 to 800 mg/kg of Triton W.R. 1339 from day 1 to 4 is very noxious in the mouse. In only 12 to 20% of animals the gestation is not interrupted. The morphology of the morulas examined on day 4 and the results of transplantation experiments on pseudopregnant mice gives evidence that Triton W.R. 1339 has no a direct toxic effect on the fertilized egg but acts probably on the maternal organism.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D051379:Mice; D010063:Ovum / Q000187:drug effects* / Q000637:transplantation; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011247:Pregnancy; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014184:Transplantation, Homologous
D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols
Défaut d'implantation chez la souris traitée par le Triton W.R. 1339: étude après transplantation des oeufs