title: [Influence of L-leucine overloading on the level of free amino acids in the diabetic rat].
abstract: Alloxan injection in the rat results in a large increase of branched free amino acids (leucine, isoleucine, valine) in the blood, liver and muscle; it decreases most of the non essential free amino acids in liver. L-leucine administration in the diabetic rat results in a large decrease of plasma corticosterone. It increases free leucine but decreases free isoleucine and valine in blood and muscle. It decreases most of the essential free amino acids in liver.
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006130:Growth Disorders / Q000139:chemically induced; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007532:Isoleucine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D014633:Valine / Q000378:metabolism
chemical_list: D000596:Amino Acids; D007328:Insulin; D007532:Isoleucine; D007930:Leucine; D014633:Valine; D003345:Corticosterone
vernacular_title: Influence d'une surcharge en L-leucine sur les teneurs en acides aminés libres chez le rat diabétique