title: The chamber-scarification test for irritancy.
abstract: A procedure has been designed (the chamber-scarification test), which possesses greatly increased sensitivity for assessing the irritancy of topically applied materials. A forearm test site is criss-cross scarified by drawing a 30-gauge needle over the skin with just enough pressure to cleave the epidermis without drawing blood. The test agent is applied in an aluminum chamber once daily for 3 days. The advantages of the method over conventional patch testing are: enhanced capacity to measure mild irritants, reduced time (3 days versus 10 to 21 days), less effort, less cost, less discomfort for the volunteers and greater reproducibility.
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced; D000287:Administration, Topical; D003358:Cosmetics / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007509:Irritants; D012882:Skin Tests / Q000379:methods*
chemical_list: D003358:Cosmetics; D007509:Irritants