Chymopapain chemonucleolysis in lumbar disk disease.
Experience with chymopapain chemonucleolysis in 1,200 cases of lumbar disk disease indicates that it is an effective method of relieving pain resulting from an abnormal intervertebral disk. Complications were few; anaphylaxis occurring immediately after injection was by far the most serious. With the use of a corticosteroid and an antihistamine in preoperative preparation, the incidence of anaphylaxis had dropped, although it still occurs. On long-term follow-up, chemonucleolysis appears to be as good as laminectomy in properly selected cases.
D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D001416:Back Pain / Q000188:drug therapy; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005500:Follow-Up Studies; D006801:Humans; D007278:Injections, Spinal; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000187:drug effects*; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009192:Myelography; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits; D012585:Sciatica / Q000188:drug therapy; D013997:Time Factors
D010447:Peptide Hydrolases