Increased protein synthesis during right ventricular hypertrophy following pulmonary stenosis in the dog.
The synthesis rates of mixed protein in the left and right ventricles were the same in normal dogs, averaging 7.8% per day. After five days, pulmonary stenosis protein synthesis rate in the right ventricle increased rapidly to 13.6% per day and subsequently decreased to near normal by 12 days, during which time the right ventricle protein mass increased by 48% after five days and by 73% after 12 days. Similarly the synthesis rate of the myofibrillar and sarcoplasmic proteins was almost doubled after five days of stenosis. The protein synthesis rate in the left ventricle did not change significantly during the 24 days of pulmonary stenosis.
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism*; D004285:Dogs; D006352:Heart Ventricles / Q000378:metabolism; D007700:Kinetics; D009124:Muscle Proteins / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism; D011666:Pulmonary Valve Stenosis / Q000150:complications / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D009124:Muscle Proteins