Morphological and biochemical defects in muscles of human carriers of the malignant hyperthermia syndrome.
This communication presents evidence in support of a neuropathic basis for the myopathy associated with malignant hyperpyrexia (MH). Muscle from MH susceptible individuals showed a reduced calcium uptake by the sarcoplasmic reticulum. There was a reduced concentration of phosphocreatine and ATP and an increased concentration of glucose-6-phosphate in these muscle samples.
D000205:Actomyosin; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D002118:Calcium / Q000378:metabolism; D002353:Carrier State; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005958:Glucosephosphates / Q000378:metabolism; D006221:Halothane; D006801:Humans; D007223:Infant; D008305:Malignant Hyperthermia / Q000150:complications* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism; D009135:Muscular Diseases / Q000150:complications* / Q000473:pathology; D009210:Myofibrils / Q000648:ultrastructure; D010725:Phosphocreatine / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D005958:Glucosephosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D000205:Actomyosin; D006005:Phosphorylases; D003402:Creatine Kinase; D000251:Adenosine Triphosphatases; D002118:Calcium; D006221:Halothane