The action of ouabain in promoting the release of catecholamines.
It is suggested that ouabain promotes catecholamine release by causing a rise in intracellular Na+ which, in turn, causes an elevated steady-state level of intracellular Ca2+. It is suggested that the Na+-K+-ATPase is not directly involved in exocytosis at either adrenergic or cholinergic synapses.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D009928:Organ Specificity; D010042:Ouabain / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013045:Species Specificity; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
D002395:Catecholamines; D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D002118:Calcium