Comparison of two concentrations of tretinoin solution in the topical treatment of acne vulgaris.
In patients with facial acne good results were obtained by topical treatment with a 0-05 per cent solution of retinoic-acid (tretinoin) solution and with a 0-025 per cent solution. The improvement was judged by clinical assessment and by counts of comedones, papules and pustules before and after the 12-week trial. Side-effects such as irritation and erythema were less with the 0-025 per cent solution. The use of swabs impregnated with a constant volume of solution and sealed in a sachet proved to be a convenient method of application.  In the placebo group, swabs impregnated with the solvent only showed virtually no effect on facial acne.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014801:Vitamin A / Q000031:analogs & derivatives*
D014801:Vitamin A; D014212:Tretinoin