Pharmacological inhibition of salivary glands: a possible therapy for sialosis and sialoadenitis. Effect of experimentally induced beta-receptor block on the rat parotid gland.
An increase of alpha-amylase concentration and specific amylase activity (correlated to protein content) was evident already after 3 days in the parotid glands of rats treated with 2 X 2 mg/day of propranolol hydrochloride. After separation of amylase into isoenzymes, only the specific isoamylase activities were enhanced. In contrast to treatment with a guanethidine derivative (guanoxane), these changes have persisted after 3 weeks. On the strength of these results, functional inhibition of the salivary glands (i.e. blockade of secretion by beta-sympatholytic agnets) is discussed as a therapeutical possibility for the management of sialosis and sialoadenitis.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D003864:Depression, Chemical; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D007517:Isoamylase / Q000378:metabolism; D010306:Parotid Gland / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012471:Salivary Proteins and Peptides / Q000378:metabolism; D012793:Sialadenitis / Q000188:drug therapy; D012798:Sialorrhea / Q000188:drug therapy
D006146:Guanidines; D012471:Salivary Proteins and Peptides; D011433:Propranolol; D000681:Amylases; D007517:Isoamylase