Development of anti-hLH antibodies after therapy with posterior pituitary extract.
This report describes the appearance of high affinity antibodies to human LH in a girl who had been treated for diabetes insipidus with injections of pitressin tannate, plus occasional nasal insufflations of posterior pituitary powder. Immunological studies indicated that the antibody was a 7S IgG directed against the beta subunit of LH, which is not species-specific. The demonstration of immunoassayable LH in a commercially available pitressin preparation strongly suggests that this patient was immunized by bovine or porcine LH. Although studies of her urinary LH excretion and serum LH (by an interstitial cell bioassay system) suggest that at least some of her endogenous LH is not bound by the antibody, the possibility remains that this type of immunization may have important implications for the development and maintenance of normal adult pituitary-ovarian relationships.
D000906:Antibodies; D001127:Arginine Vasopressin; D002675:Child, Preschool; D003919:Diabetes Insipidus / Q000188:drug therapy*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007122:Immunoelectrophoresis; D007986:Luteinizing Hormone / Q000097:blood / Q000276:immunology*; D010904:Pituitary Gland, Posterior / Q000502:physiology*; D011863:Radioimmunoassay; D014020:Tissue Extracts / Q000009:adverse effects* / Q000627:therapeutic use; D014667:Vasopressins / Q000009:adverse effects* / Q000627:therapeutic use
D000906:Antibodies; D014020:Tissue Extracts; C016671:pitressin tannate; D014667:Vasopressins; D001127:Arginine Vasopressin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone