[The effect of a mixture of bacterial ribosomes and membrane fractions of Klebsiella pneumoniae on the development of a transplanted epithelial cancer in rats].
An association of bacterial ribosomes and cell-wall of Klebsiella pneumoniae was shown to reduce the incidence of an epidermoid carcinoma in Sprague-Dawley rats when administered subcutaneously prior the tumoral graft. Mononuclear cells accumulate around the tumor. This association was considered as a non specific adjuvant stimulating the host's intrinsic immunity to tumor antigens.
D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D002473:Cell Wall / Q000276:immunology*; D005260:Female; D007711:Klebsiella pneumoniae / Q000276:immunology; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000517:prevention & control; D010457:Peptidoglycan / Q000276:immunology; D051381:Rats; D012270:Ribosomes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D010457:Peptidoglycan
Effet d'un mélange de ribosomes bactériens et d'une fraction membranaire de Klebsiella pneumoniae sur le développement d'un cancer épithélial greffé chez le rat.