Topically applied antibiotics in acne vulgaris: clinical response and suppression of Corynebacterium acnes in open comedones.
Topical antibiotics were used on patients with acne vulgaris. Corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. Clindamycin lotion completely suppressed the growth of C acnes organisms, whereas erythromycin and tetracycline did not depress the C acnes counts. Taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides  of the face and back.
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage; D003354:Corynebacterium Infections / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage; D004918:Erythromycin Estolate / Q000008:administration & dosage; D006801:Humans; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000254:growth & development; D012867:Skin / Q000382:microbiology; D013752:Tetracycline / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D013752:Tetracycline; D004918:Erythromycin Estolate