Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases.
Determination of genetic properdin factor B(Bf) polymorphism was carried out in immunofixation electrophoresis. Genetics of factor B were also studied after ageing, conversion with cobra venom and neuraminidase. In population studies the distribution of factor B in a West German population of 1245 non-related individuals was found to be: Bf F 2.73%, Bf FS 28.43%, Bf S 65.38%. Rare phenotypes (F 1F,F 1S, FS 1, SS 1) were seen in 3.46%. In addition a new variant, designated F1.6S, was observed. The application of factor B polymorphism to 68 paternity cases is discussed.
D000375:Aging; D014644:Genetic Variation; D005860:Germany, West; D006801:Humans; D008297:Male; D009439:Neuraminidase / Q000494:pharmacology; D010334:Paternity; D010641:Phenotype; D011110:Polymorphism, Genetic; D011414:Properdin / Q000032:analysis; D012910:Snake Venoms / Q000494:pharmacology
D012910:Snake Venoms; D011414:Properdin; D009439:Neuraminidase