Thymic lymphocytes in myasthenia gravis.
Lymphocytes from the thymus glands of myasthenic patients and controls were characterized in terms of their percentages of B- and T-cells and their ability to stimulate the proliferation of autologous peripheral blood lymphocytes. Percentages of B- and T-cells were the same in the thymuses of myasthenic and control subjects. Autologous peripheral lymphocyte stimulation by thymocytes was observed in only 1 of 3 myasthenic patients, and this was with a thymus gland containing a thymoma. These results thus differ from those of other investigators.
D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D007959:Lymphocyte Culture Test, Mixed; D009157:Myasthenia Gravis / Q000276:immunology* / Q000473:pathology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D013945:Thymoma / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology; D013952:Thymus Hyperplasia / Q000276:immunology; D013953:Thymus Neoplasms / Q000276:immunology