title: Immunosuppression by embryonic liver cells.
abstract: Liver cells from embryonic and newborn mice were found to interfere with mixed lymphocyte culture (MLC) reactions measuring either cytotoxicity by 51Cr release from target cells or 3H-thymidine incorporation. In both experimental systems a suppression was noted when the stimulator cells were syngeneic or unrelated to the liver donor. In addition, 18-day embryonic and neonatal liver cells were found to interfere with production of antibodies to alpha-dinitrophenyl-poly-L-lysine (alpha-DNP-PLL) in vitro. These findings conform with the hypothesis that embryonic cells can actively suppress immune reactions and thereby prevent a possible response to self.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D004140:Dinitrophenols / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology*; D007165:Immunosuppression Therapy; D008099:Liver / Q000196:embryology / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011107:Polylysine / Q000276:immunology; D011247:Pregnancy; D013154:Spleen / Q000276:immunology
chemical_list: D004140:Dinitrophenols; D011107:Polylysine