Esophageal ulcers associated with tetracycline therapy.
Esophageal ulceration has rarely been reported secondary to medicinal agents. we have treated three patients with esophageal ulceration associated with the ingestion of tetracycline or its derivative doxycycline. In light of the strong temporal relationship between taking the capsules and the onset of the esophageal ulceration, we believe that the capsules were the cause of the ulcers. We therefore recommend an alternative agent to tetracycline or doxycycline, if possible, for patients with any esophageal obstructive element. We also recommend that patients be cautioned not to take these drugs within one hour of going to bed.
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000863:Antacids / Q000627:therapeutic use; D004318:Doxycycline / Q000009:adverse effects / Q000627:therapeutic use; D004935:Esophageal Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D013752:Tetracycline / Q000009:adverse effects* / Q000627:therapeutic use; D014456:Ulcer / Q000139:chemically induced* / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D000863:Antacids; D013752:Tetracycline; D004318:Doxycycline