[Activity of Mg 2+, Na+ and K+ stimulated ATPase in erythrocytes of patients with phobic neurosis and the effect of lithium carbonate on the enzymatic activity].
Activity of ATPases was studied in erythrocytes of patients with phobia neurosis of the 11 degree and in erythrocytes of mentally healthy patients. The total Mg2+, Na+, K+-dependent ATPase activity of patients with the neurosis was unaltered in blood. But the Mg2+-ATPase activity was increased and the Na+, K+-ATPase activity was decreased in the patients as compared with the control group. Addition of lithium carbonate into incubation mixtures exhibited different effect on the Na+, K+-stimulated ATPase depending upon the initial activity of the enzyme. In blood of patients with low initial values of the enzymatic activity it was increased. But the Na+, K+-ATPase activity was decreased by lithium carbonate in those cases when the initial enzymatic activity was high. Quantitatively the effect of lithium on the enzymatic activity was similar in the both groups of neurotic patients studied (although the direction of changes was oposite).
D000251:Adenosine Triphosphatases / Q000097:blood*; D004789:Enzyme Activation; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D010698:Phobic Disorders / Q000201:enzymology*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D008094:Lithium; D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium
Aktivnost ATF-az, stimuliruemykh Mg2+, Na+, K+, b eritrotsitakh bol' nykh nevrozom fobiĭ i deĭstvie na nikh uglekislogo litiia