Why do tumor cells have a high aerobic glycolysis?
In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and Pi by the plasma membrane Na+K+ ATPase. The high ATP activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na+K+ ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000332:Aerobiosis; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D046508:Culture Techniques; D004140:Dinitrophenols / Q000494:pharmacology; D006019:Glycolysis / Q000187:drug effects; D006868:Hydrolysis; D007773:Lactates / Q000096:biosynthesis; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism
D004140:Dinitrophenols; D007773:Lactates; D010042:Ouabain; D000255:Adenosine Triphosphate; D011794:Quercetin; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium