A new experimental model of overgrowth and consecutive exencephaly.
By intraamniotic injection of a.d. diluted rat or rabbit blood plasma in 3-day chick embryos overgrowth and consecutive cranioschisis and exencephaly may be induced. Control experiments exclude colloid-osmotic mechanism. Morphological changes suggest an early general disturbance of brain wall morphogenesis and differentiation.
D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D002642:Chick Embryo; D004195:Disease Models, Animal