Effects of hemodynamic overload on canine myocardial myosin.
After mild banding of pulmonary artery in dogs there was a rapid elevation in protein and RNA synthesis, followed by an elevation in myosin content and myosin ATPase activity. There was an increase in myosin ATPase activity when K+ or Ca++ was used as activator effector but not with the cations, Mn++ or NH4+. Concomitant with an increase in myosin ATPase activity there was a decrease in one of the C1 light chain components, previously named C1d.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D006332:Cardiomegaly / Q000201:enzymology / Q000378:metabolism*; D004285:Dogs; D004789:Enzyme Activation; D008345:Manganese / Q000494:pharmacology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009218:Myosins / Q000032:analysis / Q000096:biosynthesis*; D011188:Potassium / Q000494:pharmacology
D000643:Ammonium Chloride; D008345:Manganese; D000251:Adenosine Triphosphatases; D009218:Myosins; D011188:Potassium; D002118:Calcium