Evaluation of danazol as an oral contraceptive.
The effect of Danazol as an oral contraceptive in doses of 50, 100, and 200 mg daily for 6 months was studied in 3 groups of 10 women. Both 50 and 100 mg Danazol daily were well tolerated, but one pregnancy occurred among the women receiving 50 mg daily, and 2 pregnancies occurred in women receiving 100 mg daily. There were no pregnancies in women taking 200 mg Danazol daily; however, the side effects were frequent and 5 of the 10 patients withdrew from the study prior to 6 months of therapy. Six patients in this study were followed intensively with blood hormone analysis, vaginal cytology, and pathologic evaluation, and these findings are detailed.
D000152:Acne Vulgaris / Q000139:chemically induced; D000328:Adult; D001706:Biopsy; D001834:Body Water / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003278:Contraceptives, Oral, Hormonal; D003613:Danazol / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004717:Endometrium / Q000473:pathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000139:chemically induced; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D011245:Pregnadienes / Q000008:administration & dosage*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
D003278:Contraceptives, Oral, Hormonal; D011245:Pregnadienes; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003613:Danazol