[Plurality in the determinism of organophosphorus teratogenic effects (author's transl)].
In Quail embryos, nicotinamide prevents beak and legs abnormalities produced by bidrin but remains inefficient against vertebral defects induced by bidrin and parathion. In contrast, the vertebral deficiencies are greatly alleviated or abolished by pralidoxim, an antidote known and used in organophosphorus intoxications. From these observations, a plurality in the determinism of teratogenic effects induced by organophosphorus compounds is evident.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000818:Animals; D005260:Female; D009536:Niacinamide / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010063:Ovum / Q000187:drug effects; D010278:Parathion / Q000633:toxicity; D011220:Pralidoxime Compounds / Q000494:pharmacology; D011784:Quail; D013131:Spine / Q000002:abnormalities*; D013723:Teratogens
D009943:Organophosphorus Compounds; D011220:Pralidoxime Compounds; D013723:Teratogens; D009536:Niacinamide; D010278:Parathion; C000944:dicrotophos
Pluralité dans le déterminisme des effets tératogènes des composés organophosphorés