[Comparative study of neurophysiological effects of unsubstituted phenol ethers of alpha mono- and diglycerides].
The addition of a second alpha-glyceryl to alpha-phenoxypropanediol strongly modifies the inhibitor actions on the synaptic transmission. These new di-ethers do not show solubility nor effect on the water superficial tension and simultaneously do not provoke any neurophysiological inhibitor effect. The ability of cellular penetration by lipidic solubility seems a necessary condition for pharmacological effect of alpha-glyceric ethers.
D000818:Animals; D002396:Catechols / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects; D005989:Glycerides / Q000138:chemical synthesis / Q000494:pharmacology*; D006873:Hydroquinones / Q000494:pharmacology; D051379:Mice; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D012118:Resorcinols / Q000494:pharmacology
D002396:Catechols; D005989:Glycerides; D006873:Hydroquinones; D010647:Phenyl Ethers; D012118:Resorcinols
Etude comparative des effets neurophysiologiques des éthers phénoliques non substitués mono- et diglycériques alpha