title: Cytogenetic studies and clinical implications in patients with Sézary syndrome.
abstract: Chromosome studies were carried out on 11 National Institutes of Health (N.I.H.) patients who had the diagnosis of Sézary syndrome. Heteroploidy, multiple markers including minute and ring chromosomes, and a lack of modality and clone formation, were the common chromosomal findings in this syndrome. Abundant spontaneous division of heteroploid cells in unstimulated peripheral blood cultures, a high percentage of heteroploid cells in stimulated culture, and finally, clone formation, are signs of a fulminant process and lead to the terminal phase of this disease. Early chemotherapeutic eradication of these heteroploid neoplastic cells would, therefore, be the treatment of choice in this disease.
mesh_terms: D000328:Adult; D000368:Aged; D001773:Blood Cells / Q000648:ultrastructure; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003873:Dermatitis, Exfoliative / Q000097:blood / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D013577:Syndrome; D013601:T-Lymphocytes / Q000648:ultrastructure