Mechanics of the isolated ventricular myocardium of rats conditioned by physical training.
Force-velocity relations from after-loaded contractions, from isometric and isotonic QR experiments, resting-tension curves and biochemical analyses were conducted on sixteen trabecular muscles (SH) from hearts of rats conditioned by eight weeks of swimming training (increase in heart weight 8%), and compared to a control (CH) of eighteen trabecular muscles. (SH) showed increased tension development (p less than 0.01), whereas the diastolic properties remained almost unchanged. Analysis of the amount of hydroxyproline did not prove any variation. Vmax of (SH) was only slightly increase when there was a singificnat rise in actomyosin and myosin ATPase activity, while PO of the force-velocity relations of (SH) on the x axis (tension) shifted clearly to the right (p less than 0.01). Consequently, the maximum instantaneous power of (SH), expressed by the maximum rectangular plane under the force-velocity curve, increased considerably (p less than 0.01) in comparison with (CH). The experiments show that haemodynamic load induced by training does not alter the passive properties of the myocardium, but does bring about an increase in the contractile capabiltiy.
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D001835:Body Weight; D006332:Cardiomegaly / Q000503:physiopathology; D003094:Collagen / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D009929:Organ Size; D005082:Physical Exertion; D051381:Rats; D013550:Swimming; D016276:Ventricular Function
D003094:Collagen; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D009218:Myosins; D006909:Hydroxyproline