title: [Influence on the function of lymphocytes in children with generalised mycosis during treatment with 5-fluorocytosin (author's transl)].
abstract: After LT Tests with PHA, PPE and Candidin in mixed cultures negativ or decreased results of cellular immunoreactions were obtained in cases of generalised mycosis, taking into account age-specific variations. The generalised form of mycosis having disappeared, the findings returned to normal. While in other diseases the use of metabolites always diminishes cellular immunoreactions, there is no decrease of lymphozyte transformation during treatment with 5-fc in mycosis. After a successful therapy even an increase may be found in this case. Our studies confirm the opinion that 5-FC does not influence the function of T-lymphocytes.
mesh_terms: D002177:Candidiasis / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D003596:Cytosine / Q000031:analogs & derivatives*; D005437:Flucytosine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008213:Lymphocyte Activation / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D003596:Cytosine; D005437:Flucytosine
vernacular_title: Untersuchungen über die Beeinflussung der Lymphozytenfunktion bei Kindern mit generalisierten Mykosen unter der Behandlung mit 5- Fluorocytosin.