Possible role of intestinal alkaline phosphatase activity in thiamine transport.
Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++-and (Na+ + K+)-ATPase activities did not change after the administration of ethanol. These findings show that the al-Pase activity, unlike the Ca++-ATPase activity, is not related to Ca++-absorption. A possible role of al-Pase activity in the active transport of thiamine in the intestine was discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004386:Duodenum / Q000201:enzymology*; D000431:Ethanol / Q000494:pharmacology; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D013831:Thiamine / Q000378:metabolism*; D013832:Thiamine Deficiency
D000431:Ethanol; D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases; D002118:Calcium; D013831:Thiamine