[Effects of atropine sulfate on the hypothalamic LH-RH cells of the guinea-pig].
A single 30 mg/kg., s.c. injection of atropine sulfate into male guinea pigs produces a storage of LH-RH immunoreactive material in hypothalamic neurons. In diestrus female there is no increase of immunoreactive LH-RH substance in neuron and in eminential terminals; the rate of LH-RH synthesis may be still slight. The LH-RH immunoreactive neuronal increase, in male may be related to an atropine blockade of LH-RH portal cession, perhaps via infundibular dopaminergic neurons.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D005455:Fluorescent Antibody Technique; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006168:Guinea Pigs; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008473:Median Eminence / Q000166:cytology; D011247:Pregnancy
D007987:Gonadotropin-Releasing Hormone; D001285:Atropine
Effets du sulfate d'atropine sur les cellules à LH-RH de l'hypothalamus du cobaye