Progress in understanding Huntington's chorea.
The present paper analyses the new data accumulated since 1972 concerning the etiology and pathogenesis of Huntington's chorea. Particular attention is paid to the respective roles of the dopaminergic and GABA-ergic systems.
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D001479:Basal Ganglia / Q000378:metabolism; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D002421:Caudate Nucleus / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D007031:Hypothalamus / Q000378:metabolism; D010276:Parasympatholytics / Q000627:therapeutic use; D010830:Physostigmine / Q000627:therapeutic use; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D013747:Tetrabenazine / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use
D002395:Catecholamines; D010276:Parasympatholytics; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D005680:gamma-Aminobutyric Acid; D010830:Physostigmine; D000110:Acetylcholinesterase; D005968:Glutamate Decarboxylase; D000109:Acetylcholine; D004298:Dopamine; D006719:Homovanillic Acid; D013747:Tetrabenazine