Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody IV: Effect of injection of HgCl2 prior to the antibody.
Autologous immune-complex glomerulonephritis developed in rats injected s.c. with HgCl2 2 days before the injection of anti-tubular fraction 3 antibody. The glomerulonephritis was progressive and characterized by granular deposition of IgG and C-3, with proteinuria from the eighth week onwards. Granular densities and severe glomerular basement membrane changes were observed when the experiment was terminated after 9 months. A possible mechanism of the glomerular lesion is discussed.
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D001485:Basement Membrane / Q000648:ultrastructure; D003176:Complement C3; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007105:Immune Complex Diseases; D007074:Immunoglobulin G; D007678:Kidney Glomerulus / Q000648:ultrastructure; D007684:Kidney Tubules / Q000276:immunology; D008297:Male; D008628:Mercury / Q000633:toxicity*; D008854:Microscopy, Electron; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G; D008628:Mercury