[Tumour inhibitory N-(bis--(2-chlorethyl)-aminomethyl)-urethanes (author's transl)].
The synthesis of N-[bis-(2-chlorethyl)-aminomethyl]-urethanes (I-VI) and N,N'-di[bis-(2-chlorethyl)-aminomethyl]-urea (VII) and their evaluation on the Yoshida sarcoma of the rat and on the sarcoma 180 of the mouse are described. The antitumor activity of I-VI is based on a reaction mechanism analogous to that of aromatic N-lost-derivatives.
D000818:Animals; D000970:Antineoplastic Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D006868:Hydrolysis; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D012510:Sarcoma 180 / Q000188:drug therapy*; D012517:Sarcoma, Yoshida / Q000188:drug therapy*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D014520:Urethane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity
D000970:Antineoplastic Agents; D014520:Urethane; D014508:Urea
Uber cytostatica. 22. Mitteilung. Tumorhemmende N-Bis-(2-chloräthyl)-aninomethyl]-urethane