title: Na/K- and Mg-ATPase activity in the placenta and in maternal and cord erythrocytes of pre-eclamptic patients.
abstract: Abnormal sodium balance is known to be associated with pre-eclampsia, but no investigations have been conducted concerning the enzyme which regulates active sodium transport at the cellular level. In this study, the enzyme responsible for active sodium transport--Na/K-ATPase and a nonspecific ATPase Mg-ATPase--were assayed in the placenta and in maternal and fetal (cord) erythrocytes of pregnant women with and without pre-eclampsia. Placental ATPase activity was unaffected by pre-eclampsia. However, in infants of pre-eclamptic mothers, fetal erythrocytes were found to have significantly less activity (42 per cent) of both enzymes than fetal erythrocytes from infants of normal mothers. In pre-eclamptic mothers, erythrocyte Mg-atpase activity was significantly less (41 per cent) than normal and Na/K-ATPase activity was slightly decreased (16 per cent). These results indicate that disruption of active sodium transport in fetal erythrocytes is associated with pre-eclampsia and are not inconsistent with the hypothesis of a circulating "toxin."
mesh_terms: D000251:Adenosine Triphosphatases / Q000097:blood / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D006801:Humans; D008274:Magnesium; D010920:Placenta / Q000201:enzymology*; D011188:Potassium; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy; D012964:Sodium
chemical_list: D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium