A comparison between propranolol and hypothermia in preventing ischemic contracture of the left ventricle (stone heart).
Ischemic contracture of the left ventricle ("stone heart") was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.
D000818:Animals; D006332:Cardiomegaly / Q000150:complications; D003327:Coronary Disease / Q000150:complications* / Q000188:drug therapy; D004195:Disease Models, Animal; D004285:Dogs; D006323:Heart Arrest / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D007036:Hypothermia, Induced; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000648:ultrastructure; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D014693:Ventricular Fibrillation / Q000150:complications / Q000188:drug therapy
D011433:Propranolol