Effect of 6-aminonicotinamide in teratogenic doses on the DNA- and RNA-concentration in rabbit embryos.
Pregnant rabbits were injected ip with 5 mg/kg 6-ANA at day 10, 11, 12 or 12.5 respectively of gestation. Embryos removed at day 13 of gestation had reduced DNA and RNA concentrations. The differences (DNA: 14 percent; RNA: 22.4 percent) were significant in the group treated on the twelfth day. Some possible mechanisms are discussed.
D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000014:Abnormalities, Drug-Induced; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D009536:Niacinamide / Q000031:analogs & derivatives*; D011247:Pregnancy; D012313:RNA / Q000378:metabolism*; D011817:Rabbits
D009536:Niacinamide; D015120:6-Aminonicotinamide; D012313:RNA; D004247:DNA