title: [Dynamics of the immune response in a familial focus of toxoplasmosis].
abstract: Immunoepidemiological investigations were carried out in a family in which a child with congenital toxoplasmosis was born in 1972. The following were determined: total fluorescent antibodies and their G and M fractions and G and M serum immunoglobulins. The results showed: --the existence of a familial focus if infection with T. gondii, the risk of infection in the course of pregnancy and its consequences on the product of conception; --the normal evolution of the following pregnancy in the presence of anti-T. gondii fluorescent antibodies and the birth of a normal child; --value of the indirect immunofluorescence test for the diagnosis of congenital toxoplasmosis and of the longitudinal immunologic investigation; --determination of the antibody M fraction and serum immunoglobulins did not prove as useful as expected; --persistance of fluorescent antibodies in significant titers over a long period in the absence of a clinical symptomatology or with clinical manifestations of another etiology might lead to a false diagnosis of toxoplasmosis -- hence the necessity of a test for differentiating the carrier of specific antibodies from the toxoplasmosis patient.
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis; D002353:Carrier State / Q000175:diagnosis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D014123:Toxoplasmosis / Q000175:diagnosis / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000276:immunology
chemical_list: D000906:Antibodies; D007136:Immunoglobulins
vernacular_title: Dinamica răspunsului imunitar intr-un focar familial de toxoplasmoză