Inhibitory effects of glucocorticoids on prolactin release induced by thyrotropin-releasing hormone in man.
Glucocorticoid effect on thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) release was studied in female patients with collagen or autoimmune diseases. Long-term, high dose glucocorticoid therapy tended to inhibit the response of plasma PRL to TRH. A negative correlation (r=-0.40) was found between the logarithm of total dose of glucocorticoids received and the magnitude of plasma PRL response to TRH (p less than .05).
D001327:Autoimmune Diseases / Q000097:blood; D003095:Collagen Diseases / Q000097:blood; D003864:Depression, Chemical; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D011388:Prolactin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D005938:Glucocorticoids; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin