title: Structure-activity relationships among the halogenated amphetamines.
abstract: p-Chloroamphetamine and various analogs influence brain serotonin neurons through multiple actions. Comparison of these compounds has permitted the distinction between short-term and long-term depletion of serotonin and among inhibition of tryptophan hydroxylation, release of serotonin, inhibition of serotonin reuptake, and inhibition of monoamine oxidase as mechanisms involved in the actions of these agents on serotonin neurons.
mesh_terms: D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D008694:Methamphetamine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D010133:p-Chloroamphetamine / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000662:Amphetamines; D012702:Serotonin Antagonists; D012701:Serotonin; D008694:Methamphetamine; D010133:p-Chloroamphetamine