Comparative studies of neoplastic response to a single dose of nitroso compounds. 5. The effect of dimethylnitrosamine in Swiss, ASW/SN and A-strain mice.
The tumorigenic effect of dimethylnitrosamine given once at 5 different dose levels was compared in adult Swiss, ASW/SN and A-strain mice. Considering the overall tumour incidence, at the highest dose level an increase was found in Swiss and ASW/SN mice, but not in A-strain animals. However, the effect of treatment was unequivocal for lung neoplasms. The rate of carcinomas rose significantly in all 3 strains, although a clear dose response-relationship could be established only in Swiss and ASW/SN mice. A dose-dependent effect for adenomas was found solely in Swiss mice.
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D004128:Dimethylnitrosamine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines; D013045:Species Specificity
D009602:Nitrosamines; D004128:Dimethylnitrosamine