Post-transplant monitoring of renal allograft recipients for T, B and null lymphocyte subpopulations.
Time-course studies in ten allograft recipients showed a significant reduction in the percentage of T cells in the immediate post-transplantation period. This was accompanied by an increase in the percentage of both B and 'null' cells. T, B and 'null' cell percentages reverted to normal by the 6th month after transplantation at a time when patients had achieved stable renal function and were receiving only maintenance immunosuppressive therapy. Similar trends were observed with regard to absolute number of T, B and null cells. Both pre- and post-transplant plasma samples failed to inhibit T-rosette formation. Transient B rosette inhibitory activity was, however, observed in the plasma samples of two patients but did not appear to correlate with the mixed leucocyte culture blocking factor activity (MLC-BFA) of these plasma samples. In the group of patients studied there was no apparent association between percent or absoulte T, B and 'null' cell determinations and the onset of rejection crises.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D016030:Kidney Transplantation; D007958:Leukocyte Count; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous