[Possibilities of correcting some metabolic disorders in experimental endotoxic shock by treatment with a combination of alpha-lipoic acid and epsilon aminocaproic acid].
Alpha-Lipoic acid associated with xi-aminocaproic acid proves to have a protector effect in the posttreatment of endotoxinic shock in rabbits, produced by the administration of E. coli O111, in doses of 1.5 mg/kg body weight. This effect was observed when administered early in the stage of energy privation, and was manifested by a longer survival, diminution of lactacidemia and protection of labile phosphate reserves.
D000614:Aminocaproates / Q000627:therapeutic use*; D000818:Animals; D007773:Lactates / Q000378:metabolism; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000209:etiology; D010710:Phosphates / Q000378:metabolism; D011817:Rabbits; D012772:Shock, Septic / Q000150:complications*; D008063:Thioctic Acid / Q000627:therapeutic use*
D000614:Aminocaproates; D007773:Lactates; D010710:Phosphates; D008063:Thioctic Acid
Posibilităţi de corectare a unor tulburări metabolice din şocul endotoxic experimental prin asociaţia acid alpha-lipoic--acid epsilon-aminocaproic