Adjuvancy of streptococcal nucleic acids.
A study was performed to find out whether or not RNA and DNA isolated from Group A streptococcal cytoplasm does possess adjuvant activity. The findings obtained indicate that the adjuvancy of streptococcal RNA is very similar to that of poly I:C. The adjuvant activity of poly I:C is characterized by its capacity to increase the number of pre-existing hemolysin-producing spleen cells and by its ability to increase the development of 19S and 7S producers early in the 12-day-period of primary immune response. The adjuvancy of streptococcal DNA was considerably less pronounced than that of RNA. Neither poly I:C nor streptococcal RNA and DNA were found to be capable of increasing the process of priming for the secondary immune response.
D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells; D004269:DNA, Bacterial / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005856:Germ-Free Life; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007156:Immunologic Memory; D051379:Mice; D011070:Poly I-C; D012329:RNA, Bacterial / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D011070:Poly I-C