Persistent intravascular C3 activation after bilateral nephrectomy in patients with thrombotic microangiopathy.
Four patients with thrombotic microangiopathy had evidence of intravascular C3 activation on presentation which persisted after bilateral nephrectomy. In several serum samples, C3-splitting activity was not associated with the presence of circulating immune complexes, which were detected in all four patients before nephrectomy and in three after nephrectomy.
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology; D003176:Complement C3 / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D006463:Hemolytic-Uremic Syndrome / Q000601:surgery; D006801:Humans; D006977:Hypertension, Renal / Q000276:immunology; D007105:Immune Complex Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy
D003176:Complement C3; D003165:Complement System Proteins