Functional heterogeneity among the T-derived lymphocytes of the mouse. IV. Nature of spontaneously induced suppressor cells.
When spleen cells are cultured for 4 days in the presence of fetal bovine serum, T-cells are generated which nonspecifically suppress the humoral responses of non-precultured cells to a variety of antigens. These T cells can be generated from both short-lived, sessile T1 cells and long-lived, recirculating T2 cells, and thus appear similar to suppressor T cells activated by concanavalin A.
D000818:Animals; D000941:Antigens; D000961:Antilymphocyte Serum; D002469:Cell Separation; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006736:Horses / Q000276:immunology; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D009596:Nitrophenols / Q000276:immunology; D010527:Perissodactyla / Q000276:immunology; D011135:Polysaccharides, Bacterial; D012710:Serum Albumin, Bovine; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy
D000941:Antigens; D000961:Antilymphocyte Serum; D008070:Lipopolysaccharides; D009596:Nitrophenols; D011135:Polysaccharides, Bacterial; D012710:Serum Albumin, Bovine