Cytotoxicity, mutations and DNA damage produced in Chinese hamster cells treated with streptozotocin, its analogs, and N-methyl-N'-nitro-N-nitrosoguanidine.
The activities of streptozotocin (SZ), three structural analogs of SZ, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in producing cytotoxicity, mutations to 8-azaguanine (8-AzG) resistance, and DNA damage (single-strand breaks) in V79 Chinese hamster cells have been examined. These three biological processes appear to be associated. MNNG was about 10(3) times more active on a molar basis than SZ, and the activities of the analogs fell within these extremes.
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009154:Mutation; D009604:Nitrosoguanidines / Q000494:pharmacology*; D013311:Streptozocin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009604:Nitrosoguanidines; D008769:Methylnitronitrosoguanidine; D013311:Streptozocin; D004247:DNA