[Lithium and nucleotide metabolism in brain tissue].
The paper is concerned with the influence of lithium on the metabolism of free nucleotides and the main sourse of marcoerges in the cell ATP. It was established that lithium increases the consumption of glucose by the brain tissues of rats and guinea pigs, stimulating the creation of macroegic phosphates. Lithium increases the synthesis of cyclic adenosinmonophosphates (AMP) especially on the background of stimulators of adenylatcyclase, the activity of which is inhibited by lithium and calcium and is not changed under the influence of rubidium. Lithium exerts an inhibiting action on the activity of phosphodiestherase, especially expressed on the background of detergent actions. In experimental conditions it stimulates the formation of inosinmonophosphates from AMP and by this way may change the synthesis of nucleotides in the CNS.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007292:Inosine Nucleotides / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D009711:Nucleotides / Q000378:metabolism*; D051381:Rats
D007292:Inosine Nucleotides; D009711:Nucleotides; D008094:Lithium; D000251:Adenosine Triphosphatases; D000262:Adenylyl Cyclases
Litiĭ i metabolizm nukleotidov v mozgovoĭ tkani.