Increased erythrocyte Ca2+ content in hereditary spherocytosis.
The Ca2+ content of red blood cells (RBC) appears to correlate inversely with the Ca2+-ATPase activity of the red cell membrane (Fig. 1). When hereditary spherocytosis (HS) cells and normal control erythrocytes are compared, the dependence of Ca2+ content upon ATPase activity is similar. The Ca2+ content of HS red cells is increased compared with appropriate control erythrocytes matched for cell age (Fig. 2). Splenectomy has a different effect upon HS cells than upon normal cells (Fig. 2). Erythrocytes of splenectomized patients with HS seem to contain less Ca2+ than do those of presplenectomy patients with HS, whereas the reverse appears to pertain in normal subjects.
D000251:Adenosine Triphosphatases / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002118:Calcium / Q000097:blood*; D002462:Cell Membrane / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D013103:Spherocytosis, Hereditary / Q000097:blood*; D013156:Splenectomy
D001219:Aspartate Aminotransferases; D000251:Adenosine Triphosphatases; D002118:Calcium