Immobilisation stress-induced antinociception in rats: possible role of serotonin and prostaglandins.
Immobilisation of rats for 1, 2 and 4 h induced duration-related antinociception. Antinociception induced by 4 h immobilisation was significantly inhibited after pretreatment by drugs known to inhibit synthesis of serotonin, induce degeneration of serotonergic neurones and inhibit prostaglandin synthesis. The results indicate that immobilisation stress induces autoanalgesia, which may be dependent on the availability of endogenous serotonin and prostaglandins in rat brain.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D000698:Analgesia; D000818:Animals; D004008:Diclofenac / Q000494:pharmacology; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D013315:Stress, Psychological; D013997:Time Factors
D011453:Prostaglandins; D004008:Diclofenac; D012701:Serotonin; D010134:Fenclonine; D015115:5,6-Dihydroxytryptamine; D007213:Indomethacin