title: [Metabolic activation of a natural promutagen, eugenol, by replicative cultures of adult rat liver epithelial cells].
abstract: The metabolism of eugenol via the epoxide-diol pathway has been characterized by the incubation of this compound in replicative cultures of epithelial cells from sexed rat liver. It is a naturally occuring compound which has been found as the second metabolite of a known hepatocancerogen: safrole. Eugenol did not appear as a mutagen while epoxyeugenol was mutagenic using the Ames Test.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004847:Epithelial Cells; D005054:Eugenol / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D012451:Safrole / Q000378:metabolism
chemical_list: D005054:Eugenol; D012451:Safrole
vernacular_title: Activation métabolique d'un promutagène naturel, l'eugénol, par des cultures réplicatives de cellules épithéliales de foie de rat adulte.