Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas.
Complete reversal of streptozotocin-induced diabetes mellitus in adult rats will follow transplantation of a single fetal pancreas if the organ is first grown in a normal syngeneic carrier before transfer to the diabetic recipient. Careful control of the blood sugar of diabetic recipients may enhance the function of a single donor organ and thus improve histocompatibility matching.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism / Q000601:surgery*; D008722:Methods; D010179:Pancreas / Q000196:embryology; D016035:Pancreas Transplantation; D051381:Rats; D013311:Streptozocin; D014184:Transplantation, Homologous
D001786:Blood Glucose; D013311:Streptozocin