Adenine arabinoside in idoxuridine unresponsive and intolerant herpetic keratitis.
Twenty-two patients with active herpes simplex dendritic keratitis, in whom topical idoxuridine was unsuccessful in controlling their disease, were treated with topical adenine arabinoside (ara-A), a purine analogue effective against many DNA viruses. This drug was an effective antiviral agent in these patients. No signs of ocular or adnexal toxicity were noted.
D000225:Adenine / Q000031:analogs & derivatives; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001089:Arabinose / Q000031:analogs & derivatives; D003875:Drug Eruptions; D004341:Drug Evaluation; D005938:Glucocorticoids; D006801:Humans; D007065:Idoxuridine / Q000009:adverse effects / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009824:Ointments; D011684:Purine Nucleosides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D005938:Glucocorticoids; D009824:Ointments; D011684:Purine Nucleosides; D001089:Arabinose; D000225:Adenine; D007065:Idoxuridine