title: [Oxidative phosphorylation in rat skeletal muscles in dynamics of vibration-noise effect].
abstract: The effect of vibration (vibration level of 130 dB at a frequency of 2 Hz; 108, 118, and 105 dB at frequencies of 32, 63 and 125 Hz, respectively) combined with the noise at mid- and low-frequencies (sound pressure level of 85 dBA) was studied as applied to oxidative phosphorylation in mitochondria from skeletal muscles of the rats exposed to a single action of the mentioned factors, for a fortnight and for a month. A certain separation of oxidation and phosphorylation was observed after a fortnight action of the studied factors. The expressed changes in the process of oxidative phosphorylation were detected after the vibration-noise effect for a month. A considerable decrease of the P/O coefficient (almost twice as compared to the control one) occurs when oxygen uptake by mitochondria is intensified (1.9 times) and their phosphorylation activity is lower (by 61.5%). This is accompanied by a rise (by 2.65 times) of Mg2+-activated ATPase of mitochondria and by a deficit of adenylic system components (ATP, ADP, AMP) in the muscular tissue homogenate.
mesh_terms: D000161:Acoustic Stimulation; D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009622:Noise; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D014732:Vibration
chemical_list: D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D008274:Magnesium
vernacular_title: Okisniuval'ne fosforiliuvannia v skeletnikh m'iazakh shchuriv u dinamitsi vibratsiino-shumovoi diï