[Hypothesis and experimental confirmation of a new pharmacological model of osteoarthrosis (author's transl)].
Basing on the fact that in adult articular cartilage there is an equilibrium of anabolic and catabolic processes, we developed a hypothesis that an experimentally induced reduction of anabolic reactions will lead to degenerative alterations in joint cartilage. In our experiments using monoiodine acetate, a potent inhibitory substance, we could confirm that 6-8 weeks after intraarticular injection into the knee joint of hen arthrotic processes can be observed in cartilage. By macroscopical, histological and biochemical criteria these arthrotic degenerations are in good correlation with human osteoarthrosis. Our new experimental model of osteoarthrosis in laboratory animals appears to be very sutiable for the study of degenerative articular processes and for pharmacological tests of new antiarthrotic drugs.
D000818:Animals; D002645:Chickens; D004195:Disease Models, Animal; D006025:Glycosaminoglycans / Q000378:metabolism; D007270:Injections, Intra-Articular; D007461:Iodoacetates / Q000008:administration & dosage / Q000494:pharmacology*; D007596:Joints / Q000378:metabolism / Q000473:pathology; D010003:Osteoarthritis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D006025:Glycosaminoglycans; D007461:Iodoacetates
Theoretisches Konzept und experimentell Bestätigung für ein neues Arthrose-Modell am Versuchstier