title: Toxicology of octabromobiphenyl and decabromodiphenyl oxide.
abstract: Decabromodiphenyl oxide (DBDPO) and octabromobiphenyl (OBBP) perform well as fire-retardant additives for thermoplastics. Both compounds have low acute oral toxicity and low skin absorption toxicity. They are neither primary skin irritants or skin sensitizers and are only mildly irritating to the eyes. A 30-day dietary feeding study in rats established 8 mg DBDPO/kg-day as an unequivocal no-effect level and 80 mg/kg-day as a marginal effect level. A no-effect level was not established for OBBP in a comparative study. A 2-yr rat study providing 0.1 mg DBDPO/kg-day in the diet revealed the bromine concentration reached a plateau in the liver within 30 days, while the concentration in adipose tissue slowly increased. A comparable OBBP study revealed bromine concentration in the liver and adipose tissue increased steadily and rapidly with no attainment of a plateau during 180 days of the study. Neither compound produced an accumulation of bromine in other tissues. After administration of 14C DBDPO, all 14C activity was eliminated via the feces within 2 days. After administration of 14C OBBP, 62% was eliminated with a half-life of less than 24 hr; the half-life for the remainder was greater than 16 days. In a teratology study, 10, 100, or 1000 mg DBDPO/kg-day had no effect in rats. Reproductive capacity of rats was not effected at 3, 30, or 100 mg DBDPO/kg-day. No effects were observed on cytogenetic examination of bone marrow cells of parents and weanlings from the reproduction study.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000152:Acne Vulgaris / Q000139:chemically induced; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D001966:Bromine / Q000378:metabolism; D001969:Bromobenzenes / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D004032:Diet; D004890:Erythema / Q000139:chemically induced; D005123:Eye / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D055768:Halogenated Diphenyl Ethers; D007441:Intubation, Gastrointestinal; D008099:Liver / Q000378:metabolism; D008297:Male; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D011075:Polybrominated Biphenyls; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects
chemical_list: D001713:Biphenyl Compounds; D001969:Bromobenzenes; D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C011048:octabromobiphenyl; C010902:decabromobiphenyl ether; D001966:Bromine