Effect of myocardial infarction on components of fibrinolytic system.
A systematic investigation of the fibrinolytic system during the period after acute myocardial infarction in 42 patients showed a progressive reduction of fibrinolytic activity, with the longest lysis times on days 4 to 5 after the event. There is a concomitant rise in the levels of fibrinogen, plasminogen, and antiplasmin; only the latter parallels the delay in lysis. After 12 to 15 months, normal lysis times and fibrinogen levels were found in 24 patients re-examined. It is concluded that the reduced fibrinolytic activity in these patients was a transient phenomenon after myocardial infarction.
D000328:Adult; D000368:Aged; D005340:Fibrinogen / Q000032:analysis*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D005342:Fibrinolysis; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010958:Plasminogen / Q000032:analysis; D013997:Time Factors
D005340:Fibrinogen; D010958:Plasminogen; D005341:Fibrinolysin