[The pharmaco-kinetics of angiographic contrast media with special reference to the extravascular space. Experimental studies on dogs. III. Is there an entero-hepatic circulation of angiographic contrast media? A discussion summarising the results of the entire studies (author's transl)].
The presence of an entero hepatic circulation of angiographic contrast media has been demonstrated, but quantitatively it is of little importance. About 1/2% of the contrast reaching the gut in the bile is reabsorbed and after being carried through the portal vein to the liver is re-excreted in the bile. Most of the contrastcontaining bile reaching the small bowel is excreted in the faeces; nearly all of the contrast absorbed from the colon is carried through the portal vein to the liver and after reaching the circulation is excreted by the kidneys.
D000792:Angiography; D000818:Animals; D001658:Biliary Fistula; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D004764:Enterohepatic Circulation; D005243:Feces / Q000032:analysis; D005260:Female; D007457:Iodine Radioisotopes; D007700:Kinetics
D007457:Iodine Radioisotopes; D003973:Diatrizoate; D003974:Diatrizoate Meglumine
Pharmakokinetik angiographischer Kontrastmittel unter besonderer Berücksichtigung des extravasalen Raumes. Eine experimentelle Grundlagenstudie an Hunden zur Charakterisierung der Angiographica. III. Mitteilung: Gibt es einen enterohepatischen Kreislauf angiographischer Kontrasmittel?--Zusammenfassende Diskussion der Ergebnisse aller Versuchsreihen