[Experimental study of a rostro-caudal systemization in the inferior olivary complex].
Injection of 3-acetylpyridine at a LD50 dose to albino rats produces in a few days the destruction of olivary neurons. But the caudal part of the olivary complex, particularly accessory olives, escapes the destruction by this antimetabolite of nicotinamide. Nicotinamide protects olives agains 3-acetylpyridine. However, a preliminary histoenzymological study of dehydrogenases demanding a coenzyme derived from nicotinamide has given no significant results. The authors invoke the necessity of a rostro-caudal systematization of the olivary complex, based on fine structure, connnections and metabolism of neurons.
D000818:Animals; D002452:Cell Count; D009536:Niacinamide / Q000494:pharmacology; D009847:Olivary Nucleus / Q000166:cytology* / Q000187:drug effects; D011725:Pyridines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats
D011725:Pyridines; D009536:Niacinamide
Contribution expérimentale à une systématisation rostro-caudale dans le complexe olivaire inférieur