title: [Response of the body to smallpox vaccination in persons with repeated negative vaccinal antecedents].
abstract: A study was carried out on the humoral response and vaccinal reaction after repeated administration of the smallpox vaccine (1 to 3 times), at ten days interval, to 97 subjects with a past history of repeated vaccination failures. Revaccination ended in 52.6% failures. After revaccination the antibody titer increased in 97.8% of the cases of successful vaccination and in 43.5% of the negative cases. In 29.5% of the latter cases a decrease in the antibody titer by 1--3 binary dilutions was found. The results suggest that the repeated application at short intervals of an antigenic stimulus perturbs the immune response.
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D012899:Smallpox / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000914:Antibodies, Viral
vernacular_title: Răspunsul organismului după vaccinarea antivariolică, la persoanele cu repetate antecedente vaccinale negative