The effect of antidepressants on the calcium content of the aorta of reserpine-treated rabbits.
The pre-administration of reserpine in a dose of 5 mg/kg b.o. i.v. 24 before the experiment reduced the calcium content of the thoracic aorta of rabbits weighing 1,000--1,500 g. It had no effect on the calcium level in older animals. The calcium content also fell after 10 days' administration of reserpine in daily doses of 0.1 mg/kg b.w. Pre-administration of the monoaminooxidase inhibitors phenelsine and nialamide inhibited the reserpine-induced decrease in the calcium content of the vascular wall, although by themselves they had no effect on it. Prothiadene, a thymoanaleptic, likewise inhibited, the decrease in the calcium content when administered per os in a dose of 5 mg/kg b.w. 5 hours before reserpine.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D008297:Male; D009526:Nialamide / Q000494:pharmacology; D010624:Phenelzine / Q000494:pharmacology; D011292:Premedication; D011817:Rabbits; D012110:Reserpine / Q000008:administration & dosage*
D000928:Antidepressive Agents; D012110:Reserpine; D010624:Phenelzine; D002118:Calcium; D009526:Nialamide