[Local and metastatic growth of Lewis lung carcinoma as a function of its transplantation site. Application to the study of the pharmacology of sulphadiazine triazene].
The presence of a local tumour and pulmonary metastases is studied after the administration of the Lewis Lung Carcinoma at different sites of transplantation. The intravenous administration routes, in the tail vein and in the portal vein, injections in the liver and in the muscle of the left hindleg are used. The injection in the tail vein induces pulmonary "metastases". The injection in the portal vein is followed by multiple tumours in the whole liver and pulmonary metastases. An unilobar hepatic tumour and early pulmonary metastases appear after transplantation in the liver. Intra-muscular injection gives a local tumour which can be weighed after amputation of the leg and pulmonary metastases. A test of treatment by Sulphadiazine Triazene points out a weak action on the primary tumour and a larger one on the metastases.
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D013411:Sulfadiazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014226:Triazenes / Q000627:therapeutic use*
D014226:Triazenes; D013411:Sulfadiazine
Extension tumorale et métastatique du carcinome pulmonaire de Lewis en fonction de la voie d'administration. Application à l'étude pharmacologique d'un produit