[Trace elements in several organs and mechanical properties of collagen under the influence of D-penicillamin (author's transl)].
The content of trace elements in several organs of rats under the influence of D-penicillamine (D-PA) was investigated by the neutronactivation-analysis. It could be shown an diminution of Cu, and Co under D-PA-treatment, the content of Fe, Mn, Rb and Zn was not influenced. The investigated organs didn't show any submicroscopic alterations under D-PA. On isolated collagen fibrils of tail tendon was seen a significantly diminuition of E-moduls. In accordance with Siegel the principal effect of D-PA is thought to block the synthesis of functional groups from Schiff-base crosslink precursors but not to inhibit lysyloxidase by loss of Cu-ions of connective tissue. The thermostability of D-PA influenced fibrils is changed in stretched state only and will be due to the lack of crosslink Schiff-bases; where as the shrinking point of not stretched fibrils shows only aging dependent changes.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003035:Cobalt / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism*
D014131:Trace Elements; D003035:Cobalt; D003300:Copper; D003094:Collagen; D010396:Penicillamine
Der einfluss von D-Penicillamin auf den Gehalt einiger Organe an Spurenelementen sowie auf die mechanischen Eigenschaften von Kollagen.