Is taurine-induced hypothermia in the rat mediated by 5-HT?
Intraventricular administration of taurine in the rat caused hypothermia, the extent of which was directly dependent upon the thermal gradient between the body and the environment. Pre-treatment of animals with p-chlorophenylalanine, which depleted most of the brain serotonin, strongly reduced the hypothermia induced by taurine. Pre-treatment with alpha-methyltyrosine induced hypothermia and sedation in animals. When this was followed by a taurine injection, they exhibited a decrease in body temperature which fitted the curve relating thermal gradients to hypothermic responses. It is suggested that taurine induced hypothermia in rat is mediated in part by central 5-HT systems.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003864:Depression, Chemical; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D013654:Taurine / Q000494:pharmacology*; D013997:Time Factors
D008781:Methyltyrosines; D013654:Taurine; D012701:Serotonin; D010134:Fenclonine