title: Linkage group HL-A-MLC-BF (properdin factor B). The site of the Bf locus at the immunogenetic linkage group on chromosome 6.
abstract: Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring.  In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r = 6.1%).  The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC.  From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) -- HL-A (2nd locus)--MLC-Bf---PGM(3).  The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.
mesh_terms: D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003165:Complement System Proteins; D003434:Crossing Over, Genetic; D004592:Electrophoresis, Starch Gel; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005860:Germany, West; D006680:HLA Antigens; D006648:Histocompatibility; D006649:Histocompatibility Antigens; D006801:Humans; D007125:Immunogenetics; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010641:Phenotype; D010733:Phosphoglucomutase; D011110:Polymorphism, Genetic; D011414:Properdin; D011995:Recombination, Genetic
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens; D011414:Properdin; D003165:Complement System Proteins; D010733:Phosphoglucomutase