[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)].
The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found.
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009698:Nucleoproteins / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D010128:p-Aminoazobenzene / Q000378:metabolism; D004124:p-Dimethylaminoazobenzene / Q000378:metabolism*
D002843:Chromatin; D009698:Nucleoproteins; D010128:p-Aminoazobenzene; D004124:p-Dimethylaminoazobenzene
Wechselwirkung von p-Dimethylaminoazobenzol mit Nichthistoprotein aus Rattenleberchromatin.