Effect of p-chlorophenylalnine on the loss and maintenance of tolerance to ethanol.
Rats were rendered tolerant to the motor-impairing effects of ethanol by daily oral administration. Subsequently, ethanol was withdrawn and the effect of p-chlorophenylalanine (p-CPA) on tolerance loss was examined. In two separate studies it was demonstrated that p-CPA, in a dosage regimen that produces extensive depletion of brain serotonin (5-HT), accelerated tolerance loss. These experiments suggest that at least part of p-CPA's inhibitory effect on net tolerance development to ethanol can be accounted for by its accelerating effect on tolerance loss; however, an inhibitory effect on tolerance acquisition cannot be excluded. On the other hand, once tolerance was established, p-CPA did not affect the maintenance of tolerance to ethanol.
D000818:Animals; D004347:Drug Interactions; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D010134:Fenclonine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D013997:Time Factors
D000431:Ethanol; D010134:Fenclonine