Improvement in experimental vascular graft patency by controlled defibrinogenation.
A sensitive animal model was used to investigate treatment designed to improve vascular graft patency. A Dacron graft was inserted into the infrarenal vena cava of 30 rabbits. Half were treated with subcutaneous Arvin for 28 days after operation. This produced a significant lowering of the post operative plasma fibrinogen. The patency rate of the grafts in the treated rabbits was significantly greater than in the control rabbits.
D000721:Ancrod / Q000494:pharmacology*; D000818:Animals; D001807:Blood Vessel Prosthesis; D010450:Endopeptidases / Q000494:pharmacology*; D005340:Fibrinogen / Q000032:analysis; D011093:Polyethylene Terephthalates; D011817:Rabbits; D014682:Vena Cava, Inferior / Q000601:surgery
D011093:Polyethylene Terephthalates; D005340:Fibrinogen; D010450:Endopeptidases; D000721:Ancrod