The effect of the parasympathetic autonomic nervous system on auditory fatigue.
Volunteers with normal hearing were tested for vegetative balance with the aid of vegetative reflexes and with the aid of the atropine test. The effect of white noise stimulated on hearing thresholds was then investigated together with their recovery. The vegetative system was affected experimentally by intravenous administration of atropine, and the beginning and recession of hearing fatigue was observed. Atropine caused a small change only. In a similarly arranged experiment, 1% pilocarpin administered subcutaneously in a dose of 1.4 minus 1.6 ml, resulted in increased hearing fatigue and retarded recovery at higher frequencies. The effect of pilocarpin is explained by the fact that it supports the inhibitory processes checked by the parasympathetic nervous system on the periphery.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000161:Acoustic Stimulation; D000328:Adult; D001285:Atropine / Q000494:pharmacology; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D003051:Cochlea / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D005221:Fatigue / Q000139:chemically induced / Q000503:physiopathology*; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008575:Meniere Disease / Q000188:drug therapy; D009622:Noise; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D010862:Pilocarpine / Q000494:pharmacology / Q000627:therapeutic use
D010862:Pilocarpine; D001285:Atropine; D000109:Acetylcholine