Electron microscopic studies on ATPase activities in myocardial infarction.
Comparative studies of the fine structural changes and histochemical examination of adenosine triphosphatase (ATPase) activity were performed in canine ischemic heart muscle cells following left coronary artery ligation. In the intact myocardial cells, the ATPase activities were observed most intensely in the sarcoplasmic reticulum (SR), particularly in the terminal cisternae (TC), and moderately around gap junctions of the intercalated discs and on myofilaments. Ischemic cellular changes occurred three to 24 hours after coronary ligation and became severe after three to seven days. ATPase activities decreased at around 48 hours and also became weak at three to seven days. Two to three weeks after ligation, improvement of the fine structure and increase in ATPase activities were observed in the ischemic cells, suggesting recovery. ATPase activities in the ischemic cardiac cells appeared to be decreased in parallel with the process of the fine structural changes.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D006352:Heart Ventricles / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology* / Q000648:ultrastructure
D000251:Adenosine Triphosphatases