Determination of cholesterol turnover rate by a one-and two-pool kinetic analysis.
The cholesterol turnover rate in rabbits with alimentary cholesterol atherosclerosis and in guinea-pigs with chronic vitamin C deficiency was studied by a one- and two-pool kinetic analysis. The one-pool analysis yielded exaggeraged values for the turnover rate, but the turnover rate differences between the control and experimental groups in the one- and the two-pool analysis were very similar. One-pool analysis can be used in initial studies to obtain preliminary data on the effect of nutritional, pharmacological and other factors on cholesterol turnover rate.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood; D001206:Ascorbic Acid Deficiency / Q000097:blood; D002250:Carbon Radioisotopes; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary; D006224:Cricetinae; D004036:Diet, Atherogenic; D006168:Guinea Pigs; D051379:Mice; D011817:Rabbits; D051381:Rats
D002250:Carbon Radioisotopes; D002791:Cholesterol, Dietary; D002784:Cholesterol