Mitosis of maternal lymphocytes in the presence of fetal cells: possible implication in prenatal diagnosis from fetal blood samples.
The suppression of proliferation of maternal lymphocytes by the lymphocytes of their own male newborns have been tested in a PHA-induced two-way stimulation system. The mixed lymphocyte cultures of 6 out of 12 such mothers/son pairs had 23--50% metaphases with 46,XX karyotype. In 2 more cases 10% maternal metaphases have been observed. Hence, it appears that fetal lymphocytes are unable to suppress the proliferation of maternal cells completely.
D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange; D008938:Mitosis; D011247:Pregnancy; D011296:Prenatal Diagnosis