[Editorial: Discrepancies in granulocyte survival time (author's transl)].
Important discrepancies between the renewal rate of mature granulocytes measured by in vitro labelling with DF 32P and with sodium chromate 51Cr are observed. The possible explanations are reviewed: errors made in the drawing of the experimental curve of the radioactivity disappearance; labelling of long-living lymphocytes with chromium; elution of 32P; toxicity of DFP for the tagged cells. If the renewal-rate measured by using 51Cr is the real one, as it seems to be, currently accepted models of granulopoiesis will need reappraisal.
D002469:Cell Separation; D002470:Cell Survival; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D006971:Hypersplenism / Q000378:metabolism; D007531:Isoflurophate / Q000378:metabolism / Q000633:toxicity; D007962:Leukocytes / Q000502:physiology*; D008214:Lymphocytes / Q000378:metabolism; D013997:Time Factors
D007531:Isoflurophate
Editorial: Discussions et opinions sur la durée de vie intravasculaire des granulocytes