Relationships between physical training and DOCA hypertension in rats.
Swimming, if undertaken for 1 hr/day, 3 days/week for 6 weeks prior to treatment with DOCA, unilateral nephrectomy, and salt-loading, delayed the development of hypertension in rats. If the swimming were undertaken concurrently with or after initiation of treatment with the above hypertensive regime, then it was without effect on the level of blood pressure attained or the length of time required to attain a given blood pressure. Swimming in itself resulted in a significant increase in arterial blood pressure. Previous training, such as swimming, may delay the development of hypertension through an alteration in vascular structure or smooth muscle sensitivity. The increase in blood pressure noted in physically trained rats may be a consequence of the training regime itself acting as a stressor.
D000818:Animals; D001835:Body Weight; D006332:Cardiomegaly / Q000209:etiology; D003900:Desoxycorticosterone; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats
D003900:Desoxycorticosterone