Education of lymphocytes in vivo following a transient take of a matched unrelated bone-marrow graft in man.
A patient suffering from aplastic anaemia was treated by bone-marrow transplantation from an ABO- and HLA-identical, MLC- and CML-negative, unrelated donor. MLC and CML became positive after transplantation indicating that a cellular immune response had developed against lymphocyte determinants not recognized prior to sensitization in vivo. Whether these determinants are governed by genes of the HLA region is unknown at present.
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D006680:HLA Antigens