Meclofenamate does not reduce chronic hypoxic pulmonary vasoconstriction.
There was no reduction in the pulmonary pressor response to hypoxia following inhibition of prostaglandin synthesis in rats exposed to chronic hypoxia. A fall in left ventricular weight suggested that systemic pressure may have been reduced after inhibition of prostaglandin synthesis in normoxic rats.
D000531:Altitude; D000818:Animals; D006332:Cardiomegaly; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008469:Meclofenamic Acid / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects; D011652:Pulmonary Circulation / Q000187:drug effects*; D051381:Rats; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid