[Coamide stimulation of immunogenesis during experimental levomycetin therapy].
The effect of various doses of levomycetin on immunogenesis and capacity of coamide for stimulation of immunogenesis in levomycetin therapy was studied. It was found that massive five-fold doses of levomycetin sodium succinate (I and 0.5 g/kg) administered parenterally or orally inhibited immunogenesis, the inhibition being more pronounced on administration of the antibiotic per os. When levomycetin sodium succinate was used in massive doses (1 g/kg) in combination with coamide (0.5 mg/kg) the inhibition of the immune response to the antigenic stimulation was less pronounced.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002701:Chloramphenicol / Q000627:therapeutic use*; D003035:Cobalt / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations; D006388:Hemagglutinins / Q000032:analysis; D007165:Immunosuppression Therapy; D051379:Mice; D009536:Niacinamide / Q000276:immunology*; D013154:Spleen / Q000187:drug effects
D004338:Drug Combinations; D006388:Hemagglutinins; D009536:Niacinamide; D003035:Cobalt; D002701:Chloramphenicol
Izuchenie stimuliatsii immunogeneza koamida pri levomitsetino-terapii v éksperimente.