Neoantigenic expression in enzyme-inhibitor complexes. A means to demonstrate activation of enzyme systems.
Human thrombin-antithrombin III and plasmin-antiplasmin, two enzyme-inhibitor complexes composed of four different molecules, contain antigenic structures not present in the parent molecules, which can be directly quantitated in plasma with the use of non-cross-reacting antisera. It is anticipated that this neonatigenic expression is a more general phenomenon, which could provide a simple means of measuring activation of enzyme systems in biological fluids.
D000937:Antigen-Antibody Reactions; D000941:Antigens; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000276:immunology*; D006801:Humans; D007120:Immunochemistry; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000276:immunology*; D014568:Urokinase-Type Plasminogen Activator
D000941:Antigens; D013917:Thrombin; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator