The effect of products of fibrinogen digestion by plasmin (P-FDP) on the central nervous system.
Low molecular peptides, derived from fibrinogen digested by plasmin and injected either intraperitoneally or into the brain lateral ventricle, were found to act depressively on the CNS in active rats, while in fairly active rats they showed stimulatory effects. Fractionation of P-FDP on Sephadex G-25 showed that the most active peptides had a molecular weight lower than 5,000.
D000818:Animals; D001711:Biotransformation; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D005340:Fibrinogen; D005341:Fibrinolysin; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D010455:Peptides; D005340:Fibrinogen; D005341:Fibrinolysin