[Serotoninergic and adrenergic factors influencing the ovulation and reproduction in the rat].
The action of 5-hydroxytryptamine (5-HT) on ovulation and reproduction in female rats with unique or repeated treatments of p-chlorophenylalane (p-CPA) was studied under different conditions of illumination. Histological studies were carried out on the tube and ovaries, controls of the ovarian cycle and of inseminations produce by vaginal deposits. An evaluation has been made of the insemination, fecundation, number of embryos, ovarian cycle and in anothers series hypothalamic determinations of 5-HT were carried out. In one group of rats the effect of intracerebrally administration (n. accumbens septi) 6-hydroxydopamine (6-OH-DA) (250 mug) on ovulation was studied. The administration of a unique doses of p-CPA (300 mg/Kg) induces an inhibition of the reproductive cycle in all its phases and in all the rats. Which repeated doses (100 mg/Kg) reproduction was inhibited in rats maintained under continuous illumination and under continuous darkness. Ovulation studies revealed that follicle rupture, was inhibited with a unique dose of p-CPA (300 mg/Kg). The histological study showed, marked luteinitation of ovaries. The ovarian cycle after a unique dose of p-CPA showed continuous diestrus phases. The results may indicate that a decrease of cerebral 5-HT producing a hormonal change which leads to the disappearence of the oestrogenic phase, with consequent inhibition of rupture and decrease in receptivity of the female rat. The administration of 6-OH-DA in the n.accumbens septi inhibited follicle rupture giving rise to manifest lutteynitation. A further study on the degeneration of nerve fibres, suggests the posssibility of adrenergic influence in ovulation of septal structures.
D000818:Animals; D004971:Estrus / Q000187:drug effects; D005260:Female; D010134:Fenclonine / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008027:Light; D010053:Ovary / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D006892:Hydroxydopamines; D012701:Serotonin; D010134:Fenclonine
Factores serotoninérgicos y adrenérgicos que influyen en la ovulación y la reproducción de la rata