Type III (Arthus) allergic reactions and endotoxin toxicity in guinea-pigs.
Lipoplysaccharide (endotoxin) from E. coli cells produced lethal effects in guinea-pigs. Endotoxin caused no visible dermal change in normal animals, but produced skin reactions characterized by specific Arthus-type (Type III immune hypersensitivity) vascular inflammation in immunized animals. It is concluded that Arthus allergic reactions were evoked by endotoxin, however, endotoxin lethal toxicity appears independent of this process.
D000818:Animals; D001183:Arthus Reaction / Q000209:etiology* / Q000276:immunology; D004731:Endotoxins / Q000008:administration & dosage / Q000276:immunology / Q000633:toxicity*; D004926:Escherichia coli; D006168:Guinea Pigs; D007114:Immunization; D007271:Injections, Intradermal; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D012882:Skin Tests
D004731:Endotoxins