title: Atypical mixed lymphocyte culture.  Identity between mother and child in leukemia and aplastic anemia.
abstract: The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A.  Two crossovers in each family at the MLC locus or a specific defect in lymphocyte responsiveness could be possibly explantations.  The mother of each patient could be considered a potential donor for bone marrow transplantation.
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000235:genetics*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000235:genetics; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008937:Mitomycins
chemical_list: D008937:Mitomycins