Combined therapy with tetrabenazine and pimozide in Huntington's chorea: pilot study.
Current medication for Huntingtons chorea is based on compounds which affect the activity of acetylcholine and dopamine in the basal ganglia and is unsatisfactory. This report describes a small clinical trial of dopamine antagonists, tetrabenazine (Nitoman) and pimozide (Orap). Improvement was early and striking but was not maintained over the trial period of 83 weeks.
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy*; D008297:Male; D010865:Pilot Projects; D010868:Pimozide / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D013747:Tetrabenazine / Q000008:administration & dosage / Q000627:therapeutic use*
D010919:Placebos; D010868:Pimozide; D013747:Tetrabenazine