Islet cell membrane alteration by diabetogenic drugs.
Freeze-fracture of islets of Langerhans treated in vitro with diabetogenic agents alloxan and streptozotocin shows a decrease in the number of intramembranous particles of islet cell plasma membranes. This decrease is restricted to the membrane's A-fracture face and it can be prevented by experimental conditions which are known to counteract the toxic effect of both alloxan and streptozotocin.
D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects* / Q000648:ultrastructure; D009536:Niacinamide / Q000494:pharmacology; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*
D009536:Niacinamide; D013311:Streptozocin; D000496:Alloxan; D005947:Glucose