Restitution of streptozotocin induced diabetes mellitus in nude mice with pancreatic grafts from the rat.
Transplants of 1-3 rat pancreases have proven to restitute streptozotocin induced diabetes in athymic nude mice. One out of 9 diabetic nude mice showed restitution following subcutaneous implantation of 1 rat pancreas. Three out of 6 nude mice were restituted by 2-3 grafts. Implants of rat submandibular gland did not restitute nude mice similarly treated with streptozotocin. The model seems of interest in studies of inter-species transplantation of pancreas.
D000818:Animals; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000628:therapy*; D005260:Female; D008297:Male; D051379:Mice; D008819:Mice, Nude; D016035:Pancreas Transplantation; D051381:Rats; D013311:Streptozocin; D013363:Submandibular Gland / Q000637:transplantation; D014183:Transplantation, Heterologous
D013311:Streptozocin