title: Time course of electron microscopic alterations in the hypertrophied myocardium of Goldblatt rats.
abstract: In Goldblatt rats, electron microscopic investigations of morphological changes in heart tissue during the compensatroy stage of pressure induced cardiac hypertrophy were performed. Myocardial cellular size enlarged considerably within the first 4 weeks after renal artery coarctation. An enlargement of the T-tubular system is particularly striking. The ratio of myofibril volume to total cell volume is significantly increased from the 4th-24th week and can at least partially explain a rise in developed tension which occurs in spite of a frequent disarrangement of myofibrils. In later stages severe changes in the vessel walls take place and there is an augmentation of connective tissue which impairs a correlation between myocardial cell alterations and mechanical parameters.
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D006973:Hypertension / Q000150:complications; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D009210:Myofibrils / Q000473:pathology; D051381:Rats