Aminoacetonitrile (AAN)prevents connective proliferation in rat liver induced by tetrachlorcarbon. Continuous concomitant administration of AAN.
A total dose of 10 g/kg body weight of aminoacetonitrile distributed almost evenly over 35 days prevents formation of connective bands and damage of hepatocytes in the liver of rats submitted to CCl4 inhalations at a partial pressure of 1/6 atm, eight times within the same interaval. Control animals exhibited the usual pattern of CCl4 injury.
D000097:Acetonitriles / Q000627:therapeutic use*; D000607:Aminoacetonitrile / Q000627:therapeutic use*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000473:pathology / Q000517:prevention & control*; D051381:Rats
D000097:Acetonitriles; D000607:Aminoacetonitrile