[Joint action of protein-chondroitin-4-keratan-sulfate and hyaluronic acid on erythrocyte aggregation and adhesion].
It was shown that the rate and the degree of erythrocytes aggregation brought about by a mixture of protein-chondroitin-4-keratan sulfate (PCKS) and hyaluronic acid (HA) was greater than the sum of the values of the corresponding indices observed during separate independent action of these proteoglycans on the aggregation of the mentioned cells concentrations as in the mixtures. It may be supposed that such phenomenon is connected with formation in the mixture of a hybrid PCKS-HA complex which is more active in respect to the erythrocyte aggregation than its components separately.
D002448:Cell Adhesion / Q000187:drug effects; D011508:Chondroitin Sulfate Proteoglycans / Q000494:pharmacology*; D004357:Drug Synergism; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007632:Keratan Sulfate / Q000494:pharmacology*; D011509:Proteoglycans / Q000494:pharmacology*; D013268:Stimulation, Chemical
D011508:Chondroitin Sulfate Proteoglycans; D006025:Glycosaminoglycans; D011509:Proteoglycans; D006820:Hyaluronic Acid; D007632:Keratan Sulfate
Sovmestnoe deĭstvie protein-khondroitin-4-keratan-sul'fata i gialuronovoĭ kisloty na agregatsiiu i adgeziiu éritrotsitov.