Substitution of calorigenic effects of noradrenaline and adrenaline and differences in their inhibition by propranolol.
The calorigenic effect of infused adrenaline and noradrenaline was measured in cold-acclimated rats. The slopes of the dose-response curves for the two catecholamines and the maxima of the curves were the same. The adrenaline dose-response curve showed a shift to the right, towards higher infusion doses, compared with the noradrenaline curve. Thermogenesis due to the two catecholamines was not additive throughout the whole range of doses used. In interaction with noradrenaline, propranolol caused a parallel shift of the dose-response curve to the right, whereas in interaction with adrenaline it depressed the maximum. The concept that the two catecholamines act via different regulation sites on a common thermogenetic effector is discussed.
D000064:Acclimatization; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001481:Basal Metabolism / Q000187:drug effects; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D013874:Thiopental / Q000494:pharmacology
D001285:Atropine; D011433:Propranolol; D013874:Thiopental; D009638:Norepinephrine; D004837:Epinephrine