[Experimental study of the sensitizing power of methoxyflurane].
Methyoxyflurane, a halogenated general anaesthetic, showed a net sensibilizing effect in the guinea-pig when tested experimentally by the Magnusson and Klingman technique. According to these authors classification it may be classed as of "moderate allergenicity". In addition, the sensibilisation reaction obtained is prolonged. It remains at a similar level for 2 to 7 weeks after the end of the sensibilisation phase.
D000818:Animals; D004342:Drug Hypersensitivity; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D007279:Injections, Subcutaneous; D008297:Male; D008733:Methoxyflurane / Q000276:immunology* / Q000494:pharmacology
D008733:Methoxyflurane; D005620:Freund's Adjuvant
Etude expérimentale du pouvoir snesibilisant du méthoxyflurane