Reversal of ultraviolet-killing in an Escherichia coli lon mutant. Differential effects of protein synthesis inhibitors.
The effects of protein synthesis inhibition in post-irradiation treatments on the ultraviolet-survival of an Escherichia coli lon mutant were examined with six antibiotics. Kasugamycin was the most potent in enhancing the ultraviolet survival, whereas puromycin promoted ultraviolet killing rather than survival. Rifampicin, chloramphenicol, chlortetracycline, and spectinomycin were weakly active in the enhancement of survival.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D002751:Chlortetracycline / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism / Q000528:radiation effects*; D009154:Mutation; D011691:Puromycin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D011691:Puromycin; D002701:Chloramphenicol; D000198:Spectinomycin; D012293:Rifampin; D002751:Chlortetracycline