Inferior olive: its role in motor learing.
Specific chemical lesion of the rat inferior olive by intraperitoneal administration of 3-acetylpyridine prevents recuperation from motor abnormalities generated by unilateral labyrinthine lesion. Moreover, in animals that have recuperated from the balyrinthine lesion, 3-acetylpyridine produces a reversal of the symptoms within 2 hours of administration. These results indicate that the integrity of the olivo-cerebellar system is necessary for the acquisition and retention of this form of motor learning, but that the cerebellum itself is not the seat of such learning.
D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D007758:Ear, Inner / Q000502:physiology; D006246:Harmaline / Q000494:pharmacology; D009048:Motor Skills / Q000502:physiology*; D009434:Neural Pathways; D009536:Niacinamide / Q000494:pharmacology; D009847:Olivary Nucleus / Q000187:drug effects / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats
D011725:Pyridines; D009536:Niacinamide; D006246:Harmaline