title: [Stroma formation in epithelial malignant tumors].
abstract: The mechanism of stroma-formation and rearrangement of the stroma was studied on 221 cases of cancer of the lung, stomach and mammary gland using histological, histochemical and electron-microscopy methods of investigation.  It was established that multiplying epithelial elements of teh tumour induced proliferation of histiogenic and vascular fibroblasts, activating them.  Active fibroblasts play a double role: they either produce fibres and interstitial matter of the tumorous stroma, or participate in desintegration of preceding and newly formed collagenous structures.  The processes of stroma-formation comply with the conventional schemes of normal fibrillogenesis and rearrangement of the interstitial tissue.  It was shown that fibroblasts of the tumour stroma was capable of phagocytosis of a mature collagen.  It is supposed that in the course of the tumorous growth correlation between the parenchyma and stroma is maintained, the leading role being played by the epithelium.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure*; D006025:Glycosaminoglycans / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008175:Lung Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D013274:Stomach Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D014332:Tropocollagen / Q000378:metabolism
chemical_list: D006025:Glycosaminoglycans; D014332:Tropocollagen; D003094:Collagen; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase
vernacular_title: O stromoobrazovanii v épitelial'nykh zlokachestvennykh opukholiakh