[The influence of beta-sympathomimetics and so-called Ca++-antagonistic inhibitors on human heart muscle in vitro (author's transl)].
In an in vitro assay on fetal human heart muscle it was demonstrated for the first time that overstimulation by beta-sympathomimetics could cause elective parenchymal necrosis. Fenoterolhydrobromide, which is used for tocolysis on a longterm scale, induces in vitro necroses of individual heart muscle fibers according to a pathogenetic principle postulated by Flekkenstein. The combination of Fenoterolhydrobromide with a Ca++-antagonist prevents elective parenchymal necroses by reducing the Ca++-influx into the heart muscle fibers. These results suggest that elective necroses of heart muscle fibers may be not only of coronarogenic but also of metabolic origin.
D002118:Calcium / Q000378:metabolism; D004983:Ethanolamines / Q000009:adverse effects*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects*; D005315:Fetal Diseases / Q000139:chemically induced; D005318:Fetal Heart / Q000187:drug effects*; D006801:Humans; D007751:Labor, Induced; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis / Q000139:chemically induced; D011247:Pregnancy; D014700:Verapamil / Q000494:pharmacology*
D004983:Ethanolamines; D005280:Fenoterol; D014700:Verapamil; D002118:Calcium
Der Einfluss von beta-Sympathomimetika und sog. Catt-antagonistischer hemmstoffe auf den menschlichen Herzmuskel in vitro