[Ultrastructural reaction of the multipotential glia in the cerebellum of the rat after treatment with 6-aminonicotinamide].
6-Aminonicotinamide (6-AN), an antimetabolite of nicotinamide, damages the astrocytes and oligodendrocytes through a blockade of the pentose phosphate pathway. Both types of glia cells become hydropic. A third type of glia cell, described by VAUGHN and PETERS, the multipotential glia, is affected to a lesser extent. These cells phagocytize and form pseudopodia after treatment with 6-AN. Thus the multipotential glia cells are 'marked' by the action of 6-AN, since they are obviously less dependent on the pentose phosphate pathway in the carbohydrate metabolism.
D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000648:ultrastructure; D001921:Brain / Q000166:cytology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D008928:Mitochondria / Q000648:ultrastructure; D009457:Neuroglia / Q000187:drug effects* / Q000648:ultrastructure; D009536:Niacinamide / Q000031:analogs & derivatives*; D009836:Oligodendroglia / Q000187:drug effects / Q000648:ultrastructure; D010587:Phagocytosis; D051381:Rats
D009536:Niacinamide; D015120:6-Aminonicotinamide
Ultrastrukturelle Reaktion der multipotenten Glia im Kleinhirn der Ratte nach Behandlung mit 6-Aminonikotinamid