title: [Radioimmunological determination of unconjugated plasma estradiol and estriol after administration of dehydroepiandrosterone sulfate in late pregnancy].
abstract: In 16 normal and pathologic pregnancies we carried out the dehydroepiandrosterone-sulphate loading test by injection of 50 mg DHEA-S-Na intravenously. The plasma concentrations of unconjugated estradiol and estriol were measured by radioimmun-assay. The level of estradiol increased continuously, rising to a maximum 60 min after the injection. In pre-eclamptic patients and cases of intrauterine growth retardation the rise was significantly reduced. There was a good correlation between result of the test and clinical dates. In plasma concentrations of unconjugated estriol no changes could be observed within 3 hours after the injection.
mesh_terms: D003687:Dehydroepiandrosterone / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood*; D004964:Estriol / Q000097:blood*; D005260:Female; D005315:Fetal Diseases / Q000097:blood; D006801:Humans; D010927:Placental Insufficiency / Q000097:blood / Q000175:diagnosis; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011863:Radioimmunoassay
chemical_list: D003687:Dehydroepiandrosterone; D004958:Estradiol; D004964:Estriol
vernacular_title: Radioimmunologische Bestimmung des unkonjugierten Ostradiols und Ostriols im Plasma nach Dehydroepiandrosteron-Sulfat-Applikation in der Spätschwangerschaft