The effect of oxisuran on differential inhibition of cell-mediated immunity.
Oxisuran, 2-[(methylsulfinyl) acetyl] pyridine suppressed allogeneic skin graft rejection in rats. In PHA responses and one way mixed lymphocyte culture, suppression of cell-mediated immunity was indicated. However, little inhibition of PFCs was observed with Oxisuran, and unlike Azathioprine or Neocarzinostatin, Oxisuran did not concomitantly suppress antibody-producing system in rats. These data suggest that selective suppression of cell-mediated immunological responses by Oxisuran is possible in rats, and Oxisuran may be a better immunosuppressant for clinical organ transplantation.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D006084:Graft Rejection; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D011725:Pyridines; D001379:Azathioprine