Lymphocyte membrane receptors in human lymphoid leukemias.
Membrane-bound immunoglobulins, receptors for the Fc fragment of IgG and receptors for the third component of human or murine complement were used as B cell membrane markers to study peripheral blood lymphocytes from twenty-two patients with chronic lymphatic leukemia (CLL), five patients with acute lymphoblastic leukemia (ALL) and one patient with Sézary syndrome. The capacity of human T cells of forming "spontaneous rosettes" with sheep erythrocytes was employed as T cell membrane marker. In nineteen out of twenty-seven CLL or ALL cases tested a larger percentage of cells than that found in normal individuals expressed at least one of the three B cell membrane markers studied. In the patient with Sézary syndrome the percentage of cells forming "spontaneous rosettes" with sheep erythrocytes was larger than the normal, while cells bearing B cells markers were below the normal values.
D001665:Binding Sites; D002448:Cell Adhesion; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins / Q000378:metabolism; D003873:Dermatitis, Exfoliative / Q000473:pathology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013577:Syndrome; D013997:Time Factors
D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins