Further studies on an eleventh case of heavy (Hgamma1) chain disease--biosynthetic studies.
In vitro quantitative biosynthetic studies were carried out on bone marrow cells obtained from an eleventh case with gamma heavy chain disease. The findings indicate that neither cytoplasmic nor extracellular degradation was responsible for the presence of the gamma heavy chain fragment in serum. The absence of a covalent-bound light chain was also confirmed.
D000328:Adult; D001798:Blood Proteins / Q000096:biosynthesis*; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006362:Heavy Chain Disease / Q000378:metabolism*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000096:biosynthesis; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis; D008214:Lymphocytes / Q000378:metabolism
D001798:Blood Proteins; D007141:Immunoglobulin Fc Fragments; D007143:Immunoglobulin Heavy Chains; D007146:Immunoglobulin lambda-Chains