title: [Genetic bases for the selection of microorganisms using analogs].
abstract: The main mechanisms are considered for biosynthesis processes regulation by means of repression and inhibition with final products. On the basis of these mechanisms the state and prospects of the directed alteration of various stages in regulating the synthesis of primary and secondary metabolites, using breeding selection of mutants resistant to analogues are discussed. The main regularities are presented for using analogues of primary metabolites in the breeding strains with overproduction of various biologically active compounds.
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis; D001222:Aspartate Kinase / Q000096:biosynthesis; D001412:Bacillus subtilis; D001419:Bacteria / Q000378:metabolism; D001951:Brevibacterium; D003352:Corynebacterium; D003864:Depression, Chemical; D004926:Escherichia coli; D005796:Genes; D005809:Genes, Regulator; D005821:Genetic Techniques; D008837:Micrococcus; D008967:Molecular Biology / Q000187:drug effects; D009154:Mutation / Q000187:drug effects; D009492:Neurospora crassa; D011550:Pseudomonas aeruginosa; D012343:RNA, Transfer / Q000096:biosynthesis; D012242:Rhodobacter sphaeroides; D012441:Saccharomyces cerevisiae; D004718:Saccharomycetales; D012486:Salmonella typhimurium; D012641:Selection, Genetic / Q000187:drug effects; D012706:Serratia marcescens
chemical_list: D000596:Amino Acids; D012343:RNA, Transfer; D001222:Aspartate Kinase
vernacular_title: Geneticheskie osnovy selektsii mikroorganizmov s ispol'zovaniem analogov