Carcinogenicity of acetoxymethyl-methyl-nitrosamine after subcutaneous, intravenous and intrarectal applications in rats.
In comparison to the known carcinogenic properties of Acetoxymethyl-Methyl-Nitrosamine (AMMN) after oral or intraperitoneal application the dimethylnitrosamine derivative was tested by subcutaneous, intravenous and intrarectal route in male Sprague-Dawley or Wistar rats. AMMN proved to be primarily a locally acting carcinogen. However, a second mode of action is indicated by systemic carcinogenic properties found after i.v. and s.c. applications. The lung and heart, and to a less extent the kidney and earduct were found as target organs of distant carcinogenic response.
D000230:Adenocarcinoma / Q000139:chemically induced; D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D007274:Injections, Intraperitoneal; D008297:Male; D009217:Myosarcoma / Q000139:chemically induced; D009463:Neuroma / Q000139:chemically induced; D009602:Nitrosamines / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced*; D012007:Rectum
D002273:Carcinogens; D009602:Nitrosamines