title: Effect of ethylene glycol on transcription of Neurospora crassa conidial genome.
abstract: Ethylene glycol (EG) was found not to alter DNA sequences in Neurospora crassa conidia, though it is believed to be mutagenic in nature. Molecular hybridization revealed 20% increase in whole RNA transcripts in EG-treated conidia, which indicates that while untreated conidia increase RNA synthesis by 2.35fold, treated conidia are inhibited and undergo only a 1.2fold increase. Thus there is an inhibition in potential RNA synthesis, though some RNA synthesis goes on in presence of ethylene glycol.
mesh_terms: D001483:Base Sequence; D005026:Ethylene Glycols / Q000494:pharmacology*; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000235:genetics*; D012313:RNA / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D005026:Ethylene Glycols; D012313:RNA