Effects of streptozotocin on early rat embryos grown in culture.
Addition of 1 mg/ml streptozotocin to serum in which 10-day rat embryos are cultured reduces their growth and viability. There is therefore a risk that administration of this drug to pregnant animals to induce diabetes could also have direct, deleterious effects on the embryos.
D000818:Animals; D003470:Culture Media; D046508:Culture Techniques; D004622:Embryo, Mammalian / Q000187:drug effects*; D005865:Gestational Age; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*
D003470:Culture Media; D013311:Streptozocin