[Effect of combined administration of phenobarbital and 2-methyl-3-(o-chlorphenyl)-quinazolone-4 with hydrocortisone on the dynamics of blood corticosteroid content and ATPase activity of rat brain].
Tests conducted on rats evidenced that with combined use of hydrocortisone, 2-methyl-3-(o-chlorphenyl)-quinazolone-4 and phenobarbital the development of the hypnotic effect and the level of the blood corticosteroids were inversely proportional. The relation between the hypnotic effect and inhibition of the ATP-ase activity of the cerebral tissue homogenates in rats was observed only in experiments with phenobarbital.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000097:blood*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology*; D004338:Drug Combinations; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D011799:Quinazolines / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D011799:Quinazolines; D000251:Adenosine Triphosphatases; D006854:Hydrocortisone; D010634:Phenobarbital
Vliianie kombinirovannogo vvedeniia fenobarbitala i 2-metil-3-(o-khlorfenil)-khinazolona-4 s gidrokortizonom na dimaniku soderzhaniia kortikosteroidov v krovi i ATF-aznuiu aktivnost' golovnogo mozha krys.