Deficient phagocytic function in Papillon-Lefèvre syndrome.
The function of microphages has been studied in vitro in a 5 year-old girl with Papillon-Lefèvre syndrome. The results showed a weakness in chemotatic activity, a defect of intracellular killing of Staphylococcus aureus, and an almost normal phagocytosis but decreased intracellular killing of Candida albicans by the microphages.
D002634:Chemotaxis, Leukocyte; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000276:immunology*; D010214:Papillon-Lefevre Disease / Q000276:immunology*; D010587:Phagocytosis