[Ultrastructure of the rabbit myocardium in stages of cardiac hypertrophy induced by experimental aortic valve insufficiency].
A model of aortic insufficiency was developed in rabbits by perforating the aortic valve using a metal perforator (12 cm long) introduced via the right-hand side carotid artery. The rabbit myocardium was examined by electron microscopy in the dynamic periods of cardiac hypertrophization, i. e. in the phase of cardiac hypertrophy development (days 7 to 30 after operation), in the period of the so called stablized cardiac hypertrophy (4 to 6 months after surgery), and in the phases of hypertrophy regression (6 to 8 months after operation). The ultrastructure of myocardial cells in that particular model brought evidence of two bysic processes in the myocardium, i. e. of the usual mechanisms of myocardial ultrastructure build-up (multiplication of ribosomes and polysomes, mitochondria, and contraction apparatus neoplasia), as well as of simultaneously developing degenerative changes.
D000818:Animals; D001022:Aortic Valve Insufficiency / Q000150:complications*; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology*; D009206:Myocardium / Q000648:ultrastructure*; D011817:Rabbits
Ultrastruktúra myokardu králika vo fázach hypertrofie srdca, vyvolanej experimentálnou insuficienciou aortálnej chlopne.