[Effects of methy-2[(chloro-4'-benzoyl)-4-phenoxy]-2 propionic acid on the respiratory activity of isolated rat liver mitochondria].
The effects of methyl-2 [(chloro-4' benzoyl)-4 phenoxy]-2 propionic acid (LF 153) on mitochondrial respiration and oxidative phosphorylation are studied in vitro. Its activity is related to that of 3,5,3'-triiodo-L-thyronine (LT3), 3,5,3'-triiodothyroacetic acid (TA3), and to that of clofibrate, LF 153 acts as an inhibitory uncoupler of oxidative phosphorylation. Its uncoupling action is however very intense.
D000818:Animals; D002994:Clofibrate / Q000494:pharmacology; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology; D014475:Uncoupling Agents
D011422:Propionates; D014475:Uncoupling Agents; D014284:Triiodothyronine; D002994:Clofibrate
Effets de l'acide méthyl-2 [(chloro-4' benzoyl)-4 phénoxy]-2 propionique (lf. 153) sur l'activité respiratoire de mitochondries hépatiques isolées de rat.