[Ways of biosynthesis of dehydroepiandrosterone sulfate in the virilizing tumors of human adrenal glands].
A study was made of the ways of transformation of pregnenolone into sulfated androgens in the virilizing tumours of the human adrenal glands. Formation of sulfates of pregnenolone, 17alpha-on-pregnenolone, dehydroepiandrosterone, delta5-androsten-3beta, 17beta-diol, and testosterone was revealed in the tissue of the adrenal gland tumours. The principal sulfate forming in the tumour tissue was dehydroepiandrosterone-sulfate (DEAS). Analysis of the time changes of the pregnenolone label in the sulfates under study and in the corresponding free compounds showed that DEAS formed chiefly through the free dehydroepiandrosterone. Formation of sulfates of 17alpha-on-pregnenolone, delta5-androsten-3beta, 17beta-diol, testosterone coursed along the route of the both sulfated and free precursors.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D015114:Androstenediol / Q000378:metabolism; D001711:Biotransformation; D046508:Culture Techniques; D003687:Dehydroepiandrosterone / Q000096:biosynthesis*; D006801:Humans; D007553:Isotope Labeling; D011284:Pregnenolone / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D003687:Dehydroepiandrosterone; D011284:Pregnenolone; D015114:Androstenediol
Puti biosinteza degidroepiandrosteron-sul'fata v viriliziruiushchikh opukholiakh nadpochechnikov cheloveka