title: Diphenylhydantoin effects on salivary secretion and microsomal calcium accumulation and release.
abstract: Diphenylhydantoin inhibited calcium uptake into dog submandibular microsomes at concentrations of 0.05 mM and greater but did not affect calcium release; mesantoin and hydroxyphenyl-phenylhydantoin were without effect. Diphenylhydantoin (20 mg/kg) given i.v. significantly reduced, and mesantoin slightly reduced secretion from submandibular and parotid glands, but hydroxyphenyl-phenylhydantoin was without effect. These data suggest that the reduced secretory volume produced by diphenylhydantoin may be related to its effect on transmembrane calcium movements.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004285:Dogs; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism*; D010306:Parotid Gland / Q000378:metabolism; D010672:Phenytoin / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects*; D013363:Submandibular Gland / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D002132:Calcium Radioisotopes; D010672:Phenytoin; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D002118:Calcium