Steroid metabolism by mouse preimplantation embryos in vitro.
Mouse preimplantation embryos were incubated with radioactive pregnenolone, progesterone or dehydroepiandrosterone for various periods of time. These substrates were not converted to metabolites even after incubation of 120 h. We suggest that preimplantation mouse embryo does not possess enzyme activities for steroid metabolism.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism*; D047108:Embryonic Development; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D011247:Pregnancy; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D013256:Steroids / Q000378:metabolism*
D013256:Steroids; D003687:Dehydroepiandrosterone; D011374:Progesterone; D011284:Pregnenolone