Selective decontamination of the digestive tract of pregnant rabbits: a method for producing Enterobacteriaceae-free rabbits.
Selective elimination of the Enterobacteriaceae species from the microflora of pregnant rabbits was achieved by the use of nalidixic acid and cotrimoxazole. Animals born under Enterobacteriaceae-free conditions remained so as long as adequate isolation conditions were maintained.
D000818:Animals; D002432:Cecum / Q000382:microbiology; D004064:Digestive System / Q000382:microbiology*; D004338:Drug Combinations; D004755:Enterobacteriaceae / Q000187:drug effects*; D005243:Feces / Q000382:microbiology; D005260:Female; D005856:Germ-Free Life; D008722:Methods; D009268:Nalidixic Acid / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D011817:Rabbits / Q000382:microbiology*; D013047:Specific Pathogen-Free Organisms; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
D004338:Drug Combinations; D009268:Nalidixic Acid; D014295:Trimethoprim; D013420:Sulfamethoxazole