H-rosette formation in T-cell-proliferative diseases.
In health up to 6% of human lymphocytes will form rosettes with homologous group O rhesus-negative erythrocytes (H rosettes). Increased numbers of H rosettes were found in T-cell-proliferative diseases-- namely, infectious mononucleosis, Sézary's syndrome, and T-cell leukaemia. H-rosette formation is thus a marker for a subpopulation of T lymphocytes, and this easily performed test of T-cell activation may have clinical value in characterising changes in blood lymphocyte populations in disease.
D000017:ABO Blood-Group System; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D006801:Humans; D007104:Immune Adherence Reaction; D007244:Infectious Mononucleosis / Q000276:immunology*; D007518:Isoantibodies; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008206:Lymphatic Diseases / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000276:immunology*; D014747:Vinblastine / Q000494:pharmacology
D000017:ABO Blood-Group System; D007518:Isoantibodies; D003571:Cytochalasin B; D014747:Vinblastine; D003078:Colchicine