[Chediak-Higashi syndrome. Study of lymphocyte transformation stimulated by phytohemaglutinin (PHA)].
The reactivity to PHA stimulation of peripheral blood lymphocytes from a child with a Chediak-Higashi syndrome was studied. Lymphocyte transformation was assayed by tritiated-thymidine incorporation. Patient lymphocytes reacted to much lower concentrations of PHA than normal controls. With an optimal dose of PHA the peak of thymidine uptake occurred on day 2 of incubation instead of day 4 as observed in normals.
D002609:Chediak-Higashi Syndrome / Q000276:immunology*; D002648:Child; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D013997:Time Factors
D037102:Lectins
Maladie de Chediak-Higashi. Etude de la transformation des lymphocytes stimulés par la phytohémagglutinine (PHA)