[About degradation products of the inter-alpha-trypsin inhibitor in serum. I. The inter-alpha-trypsin inhibitor as precursor of the acid stable trypsin-plasmin-inhibitor of the serum (author's transl)].
The humoral inter-alpha-trypsin inhibitor is to define as precursor of the acid stable trypsin-plasmin-inhibitor in the serum. The inhibitor is filtrated by the glomerulum and excreted in the urine. The serum level of the inhibitor is increased in nephropathy. Using a new assay for the intact precursor it was found that during inflammation the decreased precursor level indicates an increased turnover, though the glomerular filtration of the acid-stable inhibitor is within normal range. The increase of the precursor level during nephropathy indicates that the kidney is the main degradation organe for the inter-alpha-trypsin inhibitor. Nevertheless, an increase of the acid-stable inhibitor is to be seen. This fact is only to explain if it is assumed that the inter-alpha-trypsin inhibitor is permanently degraded everywhere in the organism.
D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D006801:Humans; D007249:Inflammation / Q000097:blood; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000097:blood; D008107:Liver Diseases / Q000097:blood; D014361:Trypsin Inhibitors / Q000097:blood*; D014511:Uremia / Q000097:blood
D014361:Trypsin Inhibitors; D005341:Fibrinolysin
Uber Abbauprodukte des Inter-alpha-Trypsininhibitors im Serum. I. Der Inter-alpha-Trypsininhibitor als Prekursor des säurestabilen Serum-Trypsin-Plasmin-Inhibitors