The (Na+ + K+)-ATPase activity in brain of Quaking mice.
The (Na+ 4 K+)- and Mg2+-dependent ATPase distribution in several brain areas has been investigated in Quaking mutant mice characterized by myelin deficiency. A marked decrease of (Na+ + K+)-ATPase activity has been found in limbic structures, hypothalamus and cerebellum. The Mg2+-dependent activity did not change. A possible involvement of the impairment of the (Na+ + K+)-ATPase activity in the seizure susceptibility of this mice is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D002729:Chloromercuribenzoates / Q000494:pharmacology; D004827:Epilepsy / Q000201:enzymology*; D005459:Fluorides / Q000494:pharmacology; D007031:Hypothalamus / Q000201:enzymology; D008032:Limbic System / Q000201:enzymology; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000201:enzymology; D051379:Mice; D009186:Myelin Sheath; D009419:Nerve Tissue Proteins / Q000172:deficiency; D011149:Pons / Q000201:enzymology; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D002729:Chloromercuribenzoates; D009419:Nerve Tissue Proteins; D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D005459:Fluorides; D011188:Potassium