title: Development of spontaneous motility in chick embryos. Normal development and the activating effect of strychnine and picrotoxin.
abstract: The longitudinal development of spontaneous motility in chick embryos was studied by Kovach's method (Kovach 1970) from the 10th day of incubation up to hatching, in completely intact eggs. From the 10th to 12th day of incubation, very low amplitude movements of a burst character predominated in spontaneous motility. From the 13th day, both low and high amplitude movements could be distinguished. From the 18th day, high amplitude movements alternating with intervals of motor inactivity preponderated. This discontinuous motility, which was most pronounced on the 20th day of incubation, changed to periodic strong hatching movements. Reduction of spontaneous motility after the 17th day of incubation was not confirmed. Strychnine already activated spontaneous motility in 11-day embryos, but typical convulsions did not appear until the 15th incubation day. With picrotoxin, motility was likewise stimulated in 11-day embryos and paroxysmal activation did not occur until the 15th incubation day. In older embryos, convulsions were gradually succeeded by a continuous increase in spontaneous motility. The effect of picrotoxin had a much longer latent period than the effect of strychnine.
mesh_terms: D000818:Animals; D002642:Chick Embryo / Q000502:physiology*; D009068:Movement / Q000187:drug effects*; D010852:Picrotoxin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013331:Strychnine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D010852:Picrotoxin; D013331:Strychnine