[Effect of a change in brain monoamine levels on reproduction of an elaborated escape reaction in rats].
An escape reaction was elaborated in Wistar rats in a shuttle box to shocks delivered to the animal's foot in a time stereotype. Single administrations of serotonin precursor--5-Hydroxytryptophane (10 mg/kg) and of catecholamine inhibitor--M-tyrosine (100 mg/kg) had a facilitating effect on this reaction. The animals' behaviour became regulated; this was manifested in a shortening of latencies. Catecholamine precursor d,l-DOPA (35 mg/kg) and serotonin inhibitor p-Chlorophenilalanine (320 mg/kg) worsened the rats' adaptive behaviour in the experimental situation enhancing their fuss movements. The latencies of the escape reactions became longer. The data presented point to a reciprocal--conjugate interaction of serotonin- and noradrenergic brain systems as well as to an antistress serotonin effect on behaviour.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000502:physiology*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*; D010146:Pain; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013315:Stress, Psychological / Q000502:physiology
D008781:Methyltyrosines; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D010134:Fenclonine; D009638:Norepinephrine
Vliianie izmeneniia urovnia monoaminov mozga na vosproizvedenie vyrabotannoĭ reaktsii izbavleniia u krys.