Susceptibility of gerbils (Meriones unguiculatus) to weekly subcutaneous and single intravenous injections of N-diethylnitrosamine.
Weekly s.c. (24, 12, and 6 mg/kg b.w.) or a single i.v. (100 or 50 mg/kg b.w.) injections of N-diethylnitrosamine (DEN) to gerbils (meriones unguiculatus) resulted in tumours of the respiratory tract and liver. Carcinomata of the nasal olfactory region or respiratory-olfactory mucosal junction were most common; papillomata of the tracheobronchial system and adenomata or carcinomata of the lungs appeared in significantly lower incidences. The neoplasms of the liver were of cholangiocellular and in a few cases of hepatocellular origin.
D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage*; D004052:Diethylnitrosamine / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D005849:Gerbillinae; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008113:Liver Neoplasms / Q000139:chemically induced; D009296:Nasal Cavity / Q000187:drug effects; D009602:Nitrosamines / Q000494:pharmacology*; D009669:Nose Neoplasms / Q000139:chemically induced; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced; D013997:Time Factors
D002273:Carcinogens; D009602:Nitrosamines; D004052:Diethylnitrosamine