[Elimination of rhesus (D)-incompatible erythrocytes by (Fab')2 G-anti-D (author's transl)].
The effectiveness of (Fab')2 G-Anti-D regarding elimination of D-incompatible fetal erythrocytes, and suppression of the formation of specific antibody, was investigated in 16 probands. Using 51Cr labelled D-incompatible fetal erythrocytes and simultaneous HbF-cell counting, fast elimination of incompatible red cells, and selective accumulation in the spleen, were observed after injection of small doses of (Fab')2 G-Anti-D. None of the probands showed active formation of anti-D after 3-12 months. The doses of the (Fab')2 G-Anti-D preparation used were similar to those employed in routine use of IgG-Anti-D. The results emphasize the importance of fast immunelimination of potentially antigenic red cells and thus point to a peripheral mechanism of anti-D prophylaxis by specific anti-D.
D000017:ABO Blood-Group System; D000917:Antibody Formation; D001787:Blood Group Incompatibility / Q000517:prevention & control*; D002860:Chromium Radioisotopes; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage; D007074:Immunoglobulin G / Q000008:administration & dosage; D007165:Immunosuppression Therapy; D007275:Injections, Intravenous; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D002860:Chromium Radioisotopes; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D012204:Rh-Hr Blood-Group System
Elimination rhesus-(D)-inkompatibler Erythrozyten durch (Fab')2 G-Anti-D