Effects of delta9-tetrahydrocannabinol and cannabidiol on a Mg2+-ATPase of synaptic vesicles prepared from rat cerebral cortex.
1. delta9-Tetrahydrocannabinol and cannabidiol both exhibited a concentration-related inhibition of Mg2+-ATPase of vesicles prepared from synaptosomes isolated from rat cerebral cortex. Cannabidiol was about 3 times more potent than tetrahydrocannabinol. 2. These results were similar to those obtained previously using drugs with well established anticonvulsant activity. 3. Tetrahydrocannabinol at a sub-inhibitory concentration (1 micronM) increased the activity of the Mg2+-ATPase relative to values obtained with vehicle controls.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000201:enzymology / Q000648:ultrastructure*; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium; D008297:Male; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D013572:Synaptic Vesicles / Q000187:drug effects / Q000201:enzymology*
D002186:Cannabinoids; D002185:Cannabidiol; D000431:Ethanol; D010672:Phenytoin; D013759:Dronabinol; D000251:Adenosine Triphosphatases; D008274:Magnesium