The effects of silymarin on experimental phalloidine poisoning.
The hepatoprotective action of silymarin, the active principle extracted from the fruit of Silybum marianum (L.) Gaertn., in animals (dogs, rabbits, rats, mice) intoxicated with phalloidine is evident, both after protective and curative treatment. A dose of 15 mg/kg of silymarin protects every animal when given 60 min before the toxin. When injected 10 mim after phalloidine, a dose of 100 mg/kg of silymarin again provides total protection. However, as the time span between administration of the toxic substance and start of treatment increases, so the efficacy of silymarin decreases; after 30 min its curative effect is negligible. The histochemical and histoenzymological studies show that during intoxication of the mice by phalloidine, silymarin inhibits the effect of the toxic substance and regulates the functions of the hepatocyte, when given either 60 min before or 10 min after phalloidine.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D002952:Citric Acid Cycle / Q000187:drug effects; D004285:Dogs; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007928:Lethal Dose 50; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000506:poisoning*; D010590:Phalloidine / Q000506:poisoning*; D011817:Rabbits; D051381:Rats; D012838:Silymarin / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors
D005419:Flavonoids; D009842:Oligopeptides; D012838:Silymarin; D010590:Phalloidine; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D000251:Adenosine Triphosphatases