title: [Structure of interphase chromatin in patients with Down's syndrome and their mothers].
abstract: A method of fluorescent microscopy with the aid of acridine orange was applied in these studies; some features of the changes in the structure of interphasic chromatin characteristic of their sick children were revealed on the short-term cultures of lymphoyctes obtained from the mothers with children suffering from Down's syndrome. Sibling girls also displayed deviations similar to the changes revealed in their mothers. The data obtained permit to suppose the existence of a definite population of women, peculiarities of whose genotype promoted the appearance on the structural chromatin organization was revealed only in the mothers and sibling girls it is suggested that the mentioned genotype peculiarities were hereditary and connected with genes (or certain chromatin areas) limited by sex.
mesh_terms: D002843:Chromatin / Q000648:ultrastructure*; D004247:DNA; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008856:Microscopy, Fluorescence
chemical_list: D002843:Chromatin; D004247:DNA
vernacular_title: Strukture interfaznogo khromatina u bol'nykh s sindromom Dauna i ikh matereĭ