[Determination of the action of WR 1339 triton on the 1st stages of gestation in the mouse: action of progesterone].
Injection of 600 to 800 mg/kg of Triton W.R. 1339 from day 1 to day 4 of pregnancy is highly noxious in the mouse. Only 12 to 20% of females continue their pregnancy. The causes of this action could be determined. Triton W.R. 1339 has not a direct toxic action on the fertilized ovum, but impairs the hormonal balance of the pregnant mouse, inducing a progesterone deficiency. Daily injection of 5 mg progesterone per animal from day 1-17 or from day 4 to 17 improve pregnancy performance or suppresses completely the noxious action of Triton W.R. 1339.
D000818:Animals; D005260:Female; D051379:Mice; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000172:deficiency / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013997:Time Factors
D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols; D011374:Progesterone
Déterminisme de l'action du Triton W.R. 1339 sur les premiers stades de la gestation chez la souris: action de la progestérone