Over-production of porphyrins and heme in heterotrophic bacteria.
In Escherichia coli, Pseudomonas aeruginosa, and Achromobacter metalcaligenes gamma-aminolevulinic acid synthase and gamma-aminolevulinic acid dehydratase appear to be the rate limiting enzymes of porphyrin and heme biosynthesis. Bypassing of these enzymes by addition of gamma-aminolevulinic acid or porphobilinogen results in overproduction of tetrapyrroles.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000421:Alcaligenes / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis*; D007501:Iron / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D011162:Porphobilinogen / Q000494:pharmacology; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011166:Porphyrins / Q000096:biosynthesis*; D011524:Protoporphyrins / Q000096:biosynthesis; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D011758:Pyrroles / Q000378:metabolism
D002951:Citrates; D007773:Lactates; D011166:Porphyrins; D011524:Protoporphyrins; D011758:Pyrroles; D006418:Heme; D011162:Porphobilinogen; D000622:Aminolevulinic Acid; D007501:Iron; D000624:5-Aminolevulinate Synthetase; D000623:Porphobilinogen Synthase