[New data on luteotropic mechanism of action of estrogens during the rat estrus cycle].
An increase in peripheral blood progesterone concentration was observed in diestrus II, at 17:30 in 4-day cyclic female rats subcutaneously injected with 10 microgram estradiol benzoate (EB) at 10:00-11:00 on diestrus I. Pentobarbital injection (30 mg/kg) at 13:30 on diestrus II did not prevent this effect on EB. By contrast PB injected at 13:30 on diestrus II as above completely suppressed the luteinizing or ovulating effects of EB. The action of estrogen on blood progesterone level was therefore concluded to be unrelated to the mechanisms underlying estrogen-induced ovulation luteinization in the cyclic female rat.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D010424:Pentobarbital / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D013997:Time Factors
D011374:Progesterone; D004958:Estradiol; D010424:Pentobarbital
Données nouvelles sur les mécanismes de l'action lutéotrope des estrogènes au cours du cycle estral de la ratte.