[Role of calcium ions and fatty acids in the inhibition of Mg2+, Na+ and K+-ATPases by means of the "direct" hemolysin and phospholipase A of cobra venom].
The influence of calcium ions and fatty acids in the action of direct hemolytic factor and phospholipase A on Mg2+ and Na+, K+-ATPases was investigated. It was established that calcium activates greatly phospholipase A and to a less extent--the direct hemolytic factor. The activity of ATPases is inhibited most effectively by the system consisting of phospholipase A, direct hemolytic factor and Ca2+. Fatty acids can participate in the mechanism of membrane ATPases inhibition.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004347:Drug Interactions; D005227:Fatty Acids / Q000494:pharmacology*; D006460:Hemolysin Proteins; D010740:Phospholipases / Q000494:pharmacology*; D011188:Potassium; D012910:Snake Venoms / Q000494:pharmacology*; D012964:Sodium
D005227:Fatty Acids; D006460:Hemolysin Proteins; D012910:Snake Venoms; D012964:Sodium; D010740:Phospholipases; D000251:Adenosine Triphosphatases; D011188:Potassium; D002118:Calcium
Uchastie ionov kal'tsiia i zhirnykh kislot v tormozhenii Mg2+ i Na+, K+-ATFaz "priamym" gemolizinom i fosfolipazoĭ a iada kobry