Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.
Comparative in vivo investigations on the biotransformation of di-n-butylnitrosamine (DBNA) and (2-hydroxybutyl)-n-butylnitrosamine (HBBNA) showed the known omega-oxidation. However, a new metabolic mechanism of direct oxidative alkyl chain cleavage in the vicinity of the hydroxy group of HBBNA could be demonstrated.
D000818:Animals; D001711:Biotransformation; D002085:Butylhydroxybutylnitrosamine / Q000378:metabolism; D006900:Hydroxylation; D007700:Kinetics; D009602:Nitrosamines / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D009602:Nitrosamines; D002085:Butylhydroxybutylnitrosamine