title: Electron-microscopic evaluation of collagen fibrils after topical corticosteroid therapy.
abstract: A method used to assess the atrophogenic effect of steroids by electron microscopy after ruthenium red staining is described. In two patients more atrophy was observed after fluocinolone treatment than after hydrocortisone 17-butyrate treatment.
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy; D003094:Collagen; D003238:Connective Tissue / Q000648:ultrastructure*; D003875:Drug Eruptions / Q000209:etiology*; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives*; D008854:Microscopy, Electron; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000473:pathology / Q000648:ultrastructure
chemical_list: D000893:Anti-Inflammatory Agents; D005446:Fluocinolone Acetonide; D003094:Collagen; D006854:Hydrocortisone