[Participation of the serotoninergic system of the brain in regulation of emotional reactivity].
Vocalization and aggressiveness reactions were evoked in experiments on male Wistar rats by means of electric shock stimulation. The influence of serotonin- and dopaminergic drugs was studied in parallel on emotional reactivity and serotonin metabolism. It has been found that l-tryptophane depresses while l-Dopa intensifies emotional reactivity and aggressiveness, the latter lowering the level of endogenous serotonin and enhancing its catabolism. L-Dopa, dl-amphetamine, alpha-methyl-Dopa, parachlorophenylalanine and serotonino-blockators--deseryl and lysergide--eliminate the tranquilizing action of tryptophane on emotional reactivity, decreasing serotonin accumulation and intensifying the formation of 5-oxyindolacetic acid.
D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009949:Orientation / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists; D014364:Tryptophan / Q000494:pharmacology; D014828:Vocalization, Animal / Q000187:drug effects / Q000502:physiology
D012702:Serotonin Antagonists; D012701:Serotonin; D007980:Levodopa; D008750:Methyldopa; D014364:Tryptophan; D008238:Lysergic Acid Diethylamide; D000661:Amphetamine; D006220:Haloperidol; D010134:Fenclonine; D004298:Dopamine
Uchastie serotoninergicheskoĭ sistemy mozga v reguliatsii émotsional'noĭ reaktivnosti