[Testing synergism between ethinyl estradiol and norethisterone on the histamine-induced deciduoma and vaginal mucification of castrated rats].
Through the histaminic deciduoma test and a vaginal mucification test, we have endeavoured to show that, in spayed female rats there exists a possibility of synergism between ethynylestradiol and pure norethisterone per os. No synergism could be shown in the former test, owing to, or so it seems, a lack of deciduogenic power proper to norethisterone. The latter test showed, indeed, that ethynylestradiol can, in low quantities, bring about a synergism on the mucifying properties of norethisterone, whereas, in large quantities, it creates an antagonism on the aforesaid properties.
D000818:Animals; D002369:Castration; D002582:Cervix Mucus / Q000187:drug effects*; D003656:Decidua / Q000187:drug effects*; D004357:Drug Synergism; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006632:Histamine; D008722:Methods; D009640:Norethindrone / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D004997:Ethinyl Estradiol; D006632:Histamine; D009640:Norethindrone
Essais de synergie entre l'éthynylestradiol et la noréthistérone sur le déciduome histaminique et sur la mucification vaginale de la ratte castrée.