Effect of colchicine and demecolcine on the serum ceruloplasmin level in rats.
Six hours after the administration of demecolcine (0.3 mg/100 g b.w.), a decrease in the ceruloplasmin level was recorded in rat serum. The time course of the decrease in the rat serum ceruloplasmin concentration after the same dose of colchicine was then studied. After two to three hours, the serum ceruloplasmin concentration fell significantly in both male and female rats. Eight hours after the administration of colchicine, the serum ceruloplasmin level began to rise again in female rats, but not in male rats. Mortality among females was lower than among males.
D000818:Animals; D002570:Ceruloplasmin / Q000097:blood*; D003078:Colchicine / Q000494:pharmacology*; D003703:Demecolcine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D051381:Rats; D012737:Sex Factors
D004958:Estradiol; D002570:Ceruloplasmin; D003078:Colchicine; D003703:Demecolcine