Sodium valproate in Huntington's chorea.
In a single-case study of Huntington's Chorea the effect of sodium valproate on motor behaviour was first compared with that of L-Dopa and than investigated further alone. Drug effect was assessed in terms of number of EMG-bursts with concurrent determinations of serum-levels of sodium valproate. The main result of this study was the development of a state of tolerance to sodium valproate.
D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy*; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D014631:Valerates / Q000627:therapeutic use*; D014635:Valproic Acid / Q000627:therapeutic use*
D014631:Valerates; D007980:Levodopa; D014635:Valproic Acid