Radioprotective and toxic effects of a mixture of AET and 5-methoxytryptamine in mice.
The authors studied the radioprotective efficacy and toxicity of an AET + 5-methoxytryptamine mixture and its effect on the course of respiratory exchange, using different weight ratios of the two components. The optomum was found to be 150 mg AET/kg b.w + 25 mg 5-MOT/kg b.w. This mixture gave very good protection in the supralethal exposure range and markedly prolonged its duration. The high toxicity of this mixture was abolished by the pre-administration of glutathione. Raised and longer protection was also manifested in the course of respiratory exchange, showing that an association exists between changes in energy metabolism and raised radioresistance of the organism.
D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010101:Oxygen Consumption / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000633:toxicity*; D012119:Respiration / Q000187:drug effects; D014363:Tryptamines / Q000633:toxicity*; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*
D011837:Radiation-Protective Agents; D014363:Tryptamines; D000338:beta-Aminoethyl Isothiourea; D008735:5-Methoxytryptamine