title: Persistent intravascular C3 activation after bilateral nephrectomy in patients with thrombotic microangiopathy.
abstract: Four patients with thrombotic microangiopathy had evidence of intravascular C3 activation on presentation which persisted after bilateral nephrectomy. In several serum samples, C3-splitting activity was not associated with the presence of circulating immune complexes, which were detected in all four patients before nephrectomy and in three after nephrectomy.
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology; D003176:Complement C3 / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D006463:Hemolytic-Uremic Syndrome / Q000601:surgery; D006801:Humans; D006977:Hypertension, Renal / Q000276:immunology; D007105:Immune Complex Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy
chemical_list: D003176:Complement C3; D003165:Complement System Proteins