[Histoenzymatic studies and internal irradiation. III. Histoenzymatic changes of the kidney treated with chloromeridrin Hg 197].
The histochemical behaviour of alkaline phosphatase, adenosintriphosphatase, acid phosphatase and acetylglucosaminidase activities was studied in rat kidney treated with Chloromeridrin Hg. In these experimental conditions it was found that the nephrocytes in the proximal convoluted tubule present changes in the enzymatic activities examined, generally proportional to the doses employed. With lower doses of radionuclides, the histoenzymatic changes have a local character and are completely reversible after a month. With higher doses they take on a more extensive character and persis to some extent one month after treatment. These findings suggesti that Hg could be used clinically with due precautions.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002717:Chlormerodrin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D011830:Radiation Effects; D051381:Rats
D002717:Chlormerodrin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000118:Acetylglucosaminidase; D000251:Adenosine Triphosphatases
Ricerche istoenzimatiche ed irradiazione interna. III) Modificazioni istoenzimatiche del rene di ratto trattato con cloromeridrin Hg 197