Delineation of Robertsonian translocations in man by means of chromosome banding.
Robertsonian translocations from thirteen unrelated individuals were studied by G, Q and C banding, and by autoradiography. Each of three D-D translocations involved chromosomes 13 and 14, all four D-G translocations involved chromosomes 14 and 21, and five of six G-G translocations involved two chromsomes 21 while the sixth involved 21 and 22. Two centromeres were noted in a single 21-21 translocation chromosome by C banding. Autoradiogrpahy was much less useful in identifying the chromosomes involved in the thirteen translocations. G and Q banding were consistently accurate.
D001345:Autoradiography; D002503:Centromere; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy