Influence of alpha-adrenoceptor blockade with thymoxamine on changes in pupil diameter and accommodation produced by tropicamide and ephedrine.
In a study in 12 healthy volunteers, local instillation of thymoxamine eye-drops (0.2%) completely reversed the mydriasis produced by ephedrine (5%) but not that produced by ephedrine (5%) together with tropicamide (0.5%). Small but significant changes in accommodation were found with ephedrine and reversed by thymoxamine, suggesting that they were mediated through alpha-adrenoceptor activity. The thymoxamine eyedrops were well tolerated.
D000065:Accommodation, Ocular / Q000187:drug effects*; D000328:Adult; D004809:Ephedrine / Q000494:pharmacology*; D006801:Humans; D013948:Moxisylyte / Q000494:pharmacology*; D009184:Mydriatics / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D012965:Sodium Chloride
D009184:Mydriatics; D011725:Pyridines; D012965:Sodium Chloride; D004809:Ephedrine; D013948:Moxisylyte