Acinar cell hydropic degeneration induced by intraductal instillation of solutions into the parotid glands of the rats.
Saline or BSA were instilled 2, 5, 8 or 11 times at daily intervals into the parotid glands of rats, via Stensen's duct. Hydropic change of the acinar cells developed after 8 and 11 instillations. Histologically, the lesion was characterized by enlargement of the acinar cells, the cytoplasm of which contained vacuoles displacing the nuclei. In view of the negative results of various histochemical reactions the vacuolization was interpreted as hydropic in nature.
D000818:Animals; D005260:Female; D008297:Male; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D012710:Serum Albumin, Bovine; D012965:Sodium Chloride