[Effect of isoprenaline, in mice anesthetized with pentobarbital, on the cerebral concentration of barbiturates and on the blood levels of free fatty acids].
In mice isoprenaline increases duration of pentobarbital narcosis without modification of cerebral levels. A correlation between duration of sleep and FFA seric levels increased by isoprenaline is demonstrated. This dual effect is suppressed by pindolol. These facts suggest that hepatic metabolism of pentobarbital is slowed by lipo-mobilisation.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D010424:Pentobarbital / Q000378:metabolism / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D005230:Fatty Acids, Nonesterified; D010869:Pindolol; D010424:Pentobarbital; D007545:Isoproterenol
Influence exercée par l'isoprénaline, chez la souris endormie au pentobarbital, sur la concentration cérébrale du barbiturique et sur les taux sanguins d'acides gras libres.