Carcinogenic effects of different nitroso-compounds in Chinese hamsters. II. N-nitrosomorpholine and N-nitrosopiperidine.
A total of 320 Chinese hamsters (Cricetulus griseus) (CH) were subcutaneously (s.c.) treated with 1/5, 1/10, or 1/20 LD50 of N-nitrosomorpholine (NM) or N-nitrosopiperidine (NP). In the CH, NM and NP both produced up to a 100% rate of papillomas of the cheek pouch, tongue, pharynx, esophagus and forestomach. Occasionally squamous cell carcinomas also developed in these organs. A high rate of hepatomas was realized by NP.
D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D009062:Mouth Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000494:pharmacology*; D009603:Nitroso Compounds / Q000494:pharmacology*; D009669:Nose Neoplasms / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D010610:Pharyngeal Neoplasms / Q000139:chemically induced; D010880:Piperidines / Q000494:pharmacology*; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009025:Morpholines; D009602:Nitrosamines; D009603:Nitroso Compounds; D010880:Piperidines