title: [Effect of fibrinolysin and heparin on the kinetic properties of the thrombocytes and the oxidation-reduction processes in myocardial infarct].
abstract: Complex study of blood platelet adhesion and aggregation, blood coagulation activity and oxidation-reduction processes was conducted in dynamics in 340 patients with myocardial infarction. in 53 of them before and after treatment with fibrinolysin and heparin. It is shown that in patients with myocardial infarction, particularly in the first days of the disease and  with the development of cardiogenic shock and pulmonary edema, the adhesion and aggregation of blood platelets increase with parallel increase in the content of incompletely oxidized products in the blood. A definite parallelism was found between the changes in the kinetic properties of platelets and the oxidoreduction processes. A decrease in the platelet kinetic properties and improvement in the oxidation-reduction processes due to the effect of fibrinolysin and heparin were observed.
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005341:Fibrinolysin / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors
chemical_list: D006493:Heparin; D005341:Fibrinolysin
vernacular_title: Vliianie fibrinolizina i geparina na kineticheskie svoĭstva trombotsitov i protsessy oksidoreduktsii u bol'nykh infarktom miokarda.