[Evoked response audiometry of the guinea pig before and after drop in hearing induced by furosemid (author's transl)].
Using particular surface electrodes evoked response audiometry (ERA) can be applied to small laboratory animals without any sedation or anaesthesia. In addition to other methods we have studied in this way the influence of extreme doses of Furosemid on the guinea pig inner ear. 6-20 mg Furosemid per 100 g of bodyweight (about 100 times the human therapy dose) were applicated i.v. within 5 min resulting in a drop of hearing immediately. For the anaesthesized animal the cochlear microphonic potentials (CM) decrease simultaneously, indicating Furosemid to act at the inner ear itself. By both methods recovery of inner ear function is seen to start about 10 min later according to the little biological half life of Furosemid. As being restricted in respect of time for the CM-measurements we are sure about reversibility only by the ERA-method.
D000818:Animals; D001299:Audiometry / Q000379:methods; D007758:Ear, Inner / Q000502:physiology*; D005071:Evoked Potentials / Q000187:drug effects*; D005665:Furosemide / Q000009:adverse effects / Q000494:pharmacology*; D006168:Guinea Pigs; D006309:Hearing / Q000187:drug effects*
D005665:Furosemide
Evoked Response Audiometry (ERA) am Meerschweinchen vor und nach Lasix-induziertem