Direct cell mediated lympholysis by peripheral blood lymphocytes from renal allograft recipients.
Investigations of 22 kidney allograft recipients by the Direct CML-test revealed coincidence between acute allograft rejection and a positive test. 15 patients exhibited acute rejection, 3 chronic, and 4 no rejection episodes. 4 patients with acute rejection were not detected as positive in Direct CML, while 3 patients were positive without acute rejection, one having a chronic rejection. The exact role of HL-A antigens for the specificity of a positive Direct CML could not be evaluated from this material. It is concluded that the Direct CML-test may be helpful for the diagnosis of acute rejection, but that it has only limited power as the only test of recipients' response to foreign tissue.
D000208:Acute Disease; D002908:Chronic Disease; D006084:Graft Rejection; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D006680:HLA Antigens