title: Gas embolism death after laparoscopy delayed by "trapping" in portal circulation.
abstract: A young woman died suddenly about 1 hour after instillation of CO2 for diagnostic larparoscopy. Post-mortem x-rays revealed large volumes of gas in the portal system, the heart, and the brain. In addition, autopsy revealed gas bubbles in the coronary arteries, pulmonary hemorrhage and edema, and a probe-patent foramen ovale. We postulated the "trapping" of gas in the portal circulation and affirmed this by experiments in 6 dogs. We further postulate the delayed and intermittent release of this gas and of platelet aggregates into the systemic circulation would occur in volumes which would be insufficient to produce hemodynamic signs yet sufficient to produce serious pulmonary insult.
mesh_terms: D000328:Adult; D000818:Animals; D002245:Carbon Dioxide; D004285:Dogs; D004618:Embolism, Air / Q000401:mortality*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000401:mortality*; D008102:Liver Circulation; D010048:Ovarian Cysts / Q000601:surgery; D011027:Pneumoperitoneum / Q000401:mortality*
chemical_list: D002245:Carbon Dioxide