Vascular and extravascular spaces in a transplantable rat tumour after local X-ray irradiation.
Local X-ray irradiation of a transplantable rat tumour in a single dose of 3000 R increased significantly the extracellular space of this tumor as estimated by the plasma-tissue equilibration of 51Cr-EDTA, while the plasma and red blood cell volume as estimated with 125I-labeled albumin and 59Fe-labelled erythrocytes after sacrifice by bleeding under ether anaesthesia were unchanged. These results combined signified a decreased cell volume of cells, excluding red blood cells.
D000818:Animals; D002199:Capillary Permeability / Q000528:radiation effects; D005110:Extracellular Space / Q000528:radiation effects*; D005260:Female; D008297:Male; D008748:Methylcholanthrene; D008833:Microcirculation / Q000528:radiation effects*; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000098:blood supply* / Q000532:radiotherapy; D014184:Transplantation, Homologous; D014965:X-Rays
D008748:Methylcholanthrene