Serotonin content in the central nervous system of rats and cholinergic tremor.
Oxotremorine did not alter the level of 5-HT and 5-hydroxyindoleacetic acid in different brain regions. The content of 5-HT in the striatum was diminished by electrolytic lesions of the raphe system, by microinjection of the selective depletor 5,6-dihydroxytryptamine into the raphe system and inhibition of synthesis by pCPA or pCAM. The intensity of oxotremorine-induced tremor was reduced only in some experimental groups without clear-cut correlation to the decreased 5-HT levels. In pCPA-pretreated animals resoring of 5-HT concentration by intrastriatal microinjection of 5-HT and ip administration of 5-HT did not reestablish tremor intensity. There is no evidence that cholinergic tremor is triggered indirectly and depends upon an intact 5-HT system.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D010095:Oxotremorine / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013787:Thalamic Nuclei / Q000502:physiology; D014202:Tremor / Q000378:metabolism*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010095:Oxotremorine; D010134:Fenclonine