title: Inhibition of sodium intestinal transport and mucosal (Na+-K+)-ATPase in experimental Fanconi syndrome.
abstract: The administration of 1.5 or 9.0 mmoles/kg ip of maleate to rats induced, in addition to renal alterations similar to those occurring in the Fanconi syndrome, a decline in the intestinal mucosa (Na+-K+)-ATPase with a simultaneous decrease in sodium intestinal transport and an increase in potassium absorption. Further differences in the behavior of the two electrolytes were observed when the concentration of sodium in the perfusates was altered. No changes occurred in amino acid or glucose transport in experimental animals.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D005198:Fanconi Syndrome / Q000201:enzymology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology* / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008298:Maleates / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D008298:Maleates; D012964:Sodium; D000251:Adenosine Triphosphatases; D005947:Glucose; D011188:Potassium