[Variation of mechanical and biochemical parameters of pressure-loaded rabbit hearts following chronic administration of dipyridamole].
After constricting the aorta ascendens of rabbits, the influence of chronic administration of dipyridamole (8 mg/kg i.m. on 6 out of 7 days of the week for 3 months) upon heart hypertrophy, hemodynamics and the hydroxyproline content in the right and left ventricles, the incorporation rate of 2-[14C]-glycine into the actomyosin and soluble protein of the left ventricle was studied. The dipyridamole treatment had no effect on the increase in systolic pressure, the contractility index of the aorta-stenosed animals and heart rate. In contrast, the hypertrophic development, and consequently the increase in hydroxyproline concentration and the increased incorporation rate of 2-[14C]-glycine into the soluble protein were inhibited. The possible mechanism of action of dipyridamole on the development of heart hypertrophy in the rabbit is discussed.
D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced; D004176:Dipyridamole / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006909:Hydroxyproline / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D011817:Rabbits
D004176:Dipyridamole; D006909:Hydroxyproline
Veränderungen mechanischer und biochemischer Parameter druckbelasteter Kaninchenherzen nach chronischer Dipyridamolgabe