Extramedullary manifestation of the blastic phase of chronic myelocytic leukemia: A chromosome study.
Two patients with extramedullary manifestation of the blastic phase of chronic myelocytic leukemia (CML) are reported. 100% of the metaphases derived from extranedullary sites were aneuploid. Despite the absence of blastic changes in the bone marrow and the peripheral blood, a significant proportion of the metaphases derived from these tissues also showed aneuploidy. It is suggested that maturation and differentiation of aneuploid myeloblasts are influenced by their environment.
D000328:Adult; D000782:Aneuploidy; D002454:Cell Differentiation; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D013154:Spleen / Q000166:cytology / Q000473:pathology