[Structure-reactivity relationships and delayed neurotoxicity of organophosphorus compounds].
A correlation has been found between the reactivity in the alkaline hydrolysis reaction of a new series of organophosphates and their ability or disability to produce the clinical manifestations of delayed neurotoxicity in hen. At a dose of 1000 mg/kg only compounds exceeding a lower limit of reactivity (about 6x10-2 M-1S-1) are active.
D000818:Animals; D002645:Chickens; D005260:Female; D006868:Hydrolysis; D009474:Neurons / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D013329:Structure-Activity Relationship
D009943:Organophosphorus Compounds
Struktur-Reaktivitäs-Beziehungen und verzögerte Neurotoxizität organischer Phosphor-Verbindungen