[Effect of carnosine and anserine on excitation and contraction of fatigued skeletal muscle].
The effect of dipeptides (carnosine and anserine) on a neuromuscular preparation under fatigue or diplacine blocking is shown to result in a significant restoration of the muscle contraction. The analysis of this phenomenon evidences that synaptic processes are not responsible for the restoration, at least under the given experimental conditions. At the same time, the absence of any effect of the compounds studied on the maximal rate of isotonic shortening and on the tension of glycerinized fibres and ATPPase of native and desenitized actomyosine indicates that the contractile mechanism is not involved in the effect described. On the other hand, the dipeptides restore the value of the transmembrane potential depolarized by exhaustion, increase the amplitude of isometric twitch and the value of maximal load under isotonic conditions. Moreover, the time of the contractile cycle in the presence of the dipeptides is considcted to the processes of electromechanical coupling in skeletal muscles.
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000861:Anserine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005990:Glycerol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000201:enzymology; D009469:Neuromuscular Junction / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology; D011817:Rabbits; D013268:Stimulation, Chemical; D013997:Time Factors
D004151:Dipeptides; D003473:Neuromuscular Nondepolarizing Agents; D002336:Carnosine; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D000861:Anserine; D005990:Glycerol; D002118:Calcium
Vliianie karnozina i anzerina na vozbuzhdenie i sokrashchenie utomlennoĭ skeletnoĭ myshtsy