[The effects of dantrolene sodium on the nervous system (author's transl)].
In order to investigate the effects of Dantrolene sodium on the nervous system, the experiments were carried out on cats. 1. Group Ia spindle afferent discharges were suppressed in 6 out of 14 cases following application of the drug. The effect lasted for 20 to 90 minutes. 2. No significant effects were observed on spinal mono- and polysynaptic reflexes, nor was seen on interneurons. However, 3 out of 9 Renshaw cells were facilitated and 3 were inhibited after Dantrolene sodium application. 3. Alternating discharges in the ventral root filaments, evoked by stimulation of N. cuneiformis, were suppressed by the drug application.
D000818:Animals; D002415:Cats; D003620:Dantrolene / Q000494:pharmacology*; D003864:Depression, Chemical; D005071:Evoked Potentials / Q000187:drug effects; D006827:Hydantoins / Q000494:pharmacology*; D007395:Interneurons / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects; D009470:Muscle Spindles / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects; D012023:Reflex, Monosynaptic / Q000187:drug effects
D006827:Hydantoins; D003620:Dantrolene