6-Aminonicotinamide-induced cleft palate in the mouse: the nature of the difference between the A/J and C57Bl/6J strains in frequency of response and its genetic basis.
Cleft palate induction by 6-aminonicotinamide (6-AN) was examined in the A/J and C57BL/6J strains of mice to determine the nature of the strain difference in frequency of cleft-palate response. Probit analysis of the cleft-palate response to dose of different genotypes revealed a family of linear and parallel dose-response curves. The genotypes differ only in dosage tolerance (log ED50) to 6-AN that is required for the cleft-palate response. No evidence for a maternal cytoplasmic effect on 6-AN-induced cleft palate was found under the conditions of the present study. When the difference is dosage tolerance to 6-AN between A/J and C57BL/6J was examined with a single dose and measured by differences in frequency of induced cleft palate on a probit scale, there was some departure from genetic additivity. There was an indication off dominance deviation of the F1 embryos in the direction of C57BL/6J.A3-locus, epistatic model is proposed to account for the difference in embryonic tolerance ot 6-AN-induced cleft palate. There was a suggestion of association with the brown (b) locus.
D015120:6-Aminonicotinamide; D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000235:genetics*; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced* / Q000196:embryology / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008805:Mice, Inbred A / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*; D009536:Niacinamide / Q000031:analogs & derivatives; D011247:Pregnancy
D009536:Niacinamide; D015120:6-Aminonicotinamide