title: The effect of cardiac tamponade on coronary haemodynamics in the awake dog.
abstract: Phasic left circumflex coronary artery and aortic blood flow were monitored in six awake dogs during a control period and at several degrees of cardiac tamponade. A mean pericardial pressure of 24 plus or minus 3 mm Hg (mean plus or minus SEM) was attained at the maximum tamponade level. Total left circumflex coronary blood flow decreased 51% while the systolic portion of this flow became negative or retrograde. Following acute relief of the tamponade, a coronary hyperaemic response was noted. It it suggested that myocardial ischaemia may be partially responsible for the depressed cardiac function seen in this condition and that extravascular compression of the epicardial vessels may limit the coronary blood flow during systole.
mesh_terms: D000818:Animals; D001011:Aorta; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D002305:Cardiac Tamponade / Q000503:physiopathology*; D003201:Computers; D003326:Coronary Circulation; D004285:Dogs; D004562:Electrocardiography; D055590:Electromagnetic Phenomena; D006325:Heart Atria / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006470:Hemorrhage / Q000503:physiopathology; D010496:Pericardium / Q000503:physiopathology; D012212:Rheology; D012965:Sodium Chloride; D014655:Vascular Resistance; D014690:Venous Pressure
chemical_list: D012965:Sodium Chloride