title: Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion.
abstract: The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg +/- 0.3. Maximum blood flows occurred 111 min +/- 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.6 pg/ml to 115 pg/ml (P less than 0.001). Estriol was not detected.
mesh_terms: D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology* / Q000502:physiology; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000096:biosynthesis*; D004970:Estrone / Q000097:blood; D005260:Female; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014513:Ureter / Q000098:blood supply*
chemical_list: D004967:Estrogens; D004970:Estrone; D003687:Dehydroepiandrosterone; D004958:Estradiol