Effect of spectinomycin on T. pallidum in incubating experimental syphilis.
Animal experiments were performed to determine if a single-dose treatment for acute gonorrhoea with 2 g. spectinomycin could cure a simultaneously acquired syphilis at a very early stage of incubation. 300 treponemes (Nichols stain T. pallidum) were inoculated intratesticularly and 3 days later spectinomycin was administered in a dose which produced spectinomycin serum levels similar to those in patients who had received a single oral dose of 2 g. This dosage of spectinomycin did not prevent the development of syphilitic orchitis or reactivity to the FTA-ABS test, but it prolonged the subclinical incubation period.
D000818:Animals; D008297:Male; D009920:Orchitis / Q000188:drug therapy; D011817:Rabbits; D000198:Spectinomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013587:Syphilis / Q000188:drug therapy* / Q000382:microbiology; D013737:Testis; D014210:Treponema pallidum / Q000187:drug effects*
D000198:Spectinomycin