[Trial prevention of the embryolethal properties of suramin in the mouse by adjuvant progesterone].
Suramine, a trypanocidal drug, has an embryo-lethal and teratogenic action in Rodents. Like Triton W.R. 1339 suramine modifies the lysosomes of the visceral yolk sac. In the mouse the attempts to correct the embryolethal action by a simultaneous progesterone treatment failed while the hormonal treatment is capable to suppress the embryolethality in Triton W.R. 1339 treated mice.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D013498:Suramin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
D011374:Progesterone; D013498:Suramin
Essai de prévention du pouvoir embryoléthal de la suramine chez la souris par adjonction de progestérone