Evidence of both anti-GBM and immune complex mediated pathogenesis in the initial phase of Goodpasture's syndrome.
A 19 year old women presented with pulmonary hemorrhage, rapidly progressive glomerulonephritis and antiglomerular basement membrane antibody in her serum. In the initial phase of the disease a double layered linear deposit of IgG was seen on the glomerular capillary basement membrane together with a finely granular or focal and lumpy single layer deposit of C3 and numerous small subepithelial electron dense deposits. These findings are suggestive of the simultaneous occurrence of anti-GBM and immune complex glomerulonephritis.
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications / Q000276:immunology* / Q000473:pathology; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications* / Q000276:immunology; D007074:Immunoglobulin G; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology
D007074:Immunoglobulin G