The effects of hypoxia, hypertrophy, and diet on rat myocardial ornithine decarboxylase activity.
We have shown that there is a highly significant difference between right and left ventricular ornithine decarboxylase activity. The left ventricle had a much higher activity compared with the right ventricle. A restricted diet caused a decrease in ornithine decarboxylase activity after 24 hr. Hypoxia caused a depression of the ornithine decarboxylase activity during the first 2 days of the experiment. In the hypertrophied right ventricle there was an initial decrease in ornithine decarboxylase after 24 hr and then a gradual increase in ornithine decarboxylase activity during the 7 days of the experiment. The increase in ornithine decarboxylase activity became significant when an increase in tissue weight became apparent.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D006332:Cardiomegaly / Q000201:enzymology*; D004032:Diet; D006352:Heart Ventricles / Q000201:enzymology; D000860:Hypoxia / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009929:Organ Size; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase