[Effect of clonidine on three types of experimental hypertension and on plasma renin activity in dogs].
Intra-cisternal clonidine (3 microgram/kg) reduced hypertension and cardiac acceleration after defrenation in dogs, but did not act in intra-venous infusion (10 microgram/kg). The renin activity was not modified. Clonidine was always inactive on hypertension after stimulation of visceral afferences or after injection of potassium cyanidine. These results show that a central mechanism was implied in the anti-hypertensive action of clonidine.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D003486:Cyanides; D004285:Dogs; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D012083:Renin / Q000097:blood*
D003486:Cyanides; D012083:Renin; D003000:Clonidine
Actions de la clonidine sur trois types d'hypertension expérimentale et sur l'activité rénine plasmatique chex le chien.