[Several features of the oligomycin effect on phosphorylating oxidation of mitochondria at various states].
Effect of oligomycin on the oxygen uptake at the 4th state of the respiration chain in mitochondria with the stable coupling of respiration and phosphorylation is studied. Oligomycin is shown to inhibit the respiration in the absence of exogenous phosphorylation substrate. The inhibition curve at the 4th state is hyperbolic, at the 3d state-it is S-form. The antibiotic inhibited the oxidation of beta-hydroxybutric acid at the 4th state more intensively, than succinate oxidation. It is suggested that ATP-synthetase acts for the expense of endogenous ADP at the 4th state of the respiration chain.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D007700:Kinetics; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D013386:Succinates / Q000378:metabolism
D006885:Hydroxybutyrates; D009840:Oligomycins; D013386:Succinates; D000244:Adenosine Diphosphate; D000251:Adenosine Triphosphatases
Osobennosti deĭstviia oligomitsina na fosforilirufushchee okislenie mitokhondriĭ v razlichnykh sostoianiiakh