[Chemotherapy of gastrointestinal cancer (author's transl)].
Gastrointestinal cancer has proved exceedingly resistant to chemotherapy efforts. 5-Fluorouracil (5-FU) accepted as standard treatment, has provided only infrequent and incomplete antitumor effects. Other drugs as the nitrosoureas BCNU and CCNU or Mitomycin C do not match the effectiveness of 5-FU. Improvement in frequency of tumor regression have been recorded for gastric carcinoma with combinations of 5-FU and BCNU and 5-FU, adriamycin and Mitomycin C and for colorectal carcinoma with combination of 5-FU, methyl-CCNU and vincristine. There are also suggestions that such combination chemotherapy may produce increased survival when compared to untreated patients. The combination of 5-FU and streptozotocin in carcinoid tumors or adriamycin in primary hepatoma may be of some effectiveness.
D002276:Carcinoid Tumor / Q000188:drug therapy; D004317:Doxorubicin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D009362:Neoplasm Metastasis; D011379:Prognosis; D013311:Streptozocin / Q000627:therapeutic use
D013311:Streptozocin; D004317:Doxorubicin; D005472:Fluorouracil
Chemotherapie bei gastrointestinalen Tumoren.