Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome.
It has been demonstrated that in two patients with T-cell Sézary syndrome the pathological cells express a receptor for EA(IgM) when cultured in a medium with foetal calf or autologous serum. A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. The implications of this pathological subpopulation of T-cells are discussed.
D001665:Binding Sites; D002478:Cells, Cultured; D003873:Dermatitis, Exfoliative / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M; D008206:Lymphatic Diseases / Q000276:immunology* / Q000473:pathology; D012397:Rosette Formation; D013577:Syndrome; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007075:Immunoglobulin M