title: [Local vitamin A acid therapy in palmar/plantar hyperkeratoses (authors transl)].
abstract: Up to date, the treatment of palmar/plantar hyperkeratoses presents a therapeutic problem. The known therapeutic procedures result in short-term improvement only, if any at all. In these investigations involving 68 patients suffering from palmar/plantar hyperkeratoses of different etiology, small doses of vitamin A acid locally applied, produced a striking improvement in hypertrophic lichen planus of palms or soles: the regression was complete and in most cases permanent. The skin texture of patients with genetic keratoses and callosities became normal within a few weeks: but this condition remained free of symptoms only as long as vitamin A acid was used as a maintenance dose once or twice weekly. In hyperkeratotic eczema, pityriasis rubra pilaris, and verrucae plantaris vitamin A acid locally applied was found to be unsuitable for treatment. The possible side effects of this treatment are mentioned. Several possibilities regarding the way of action of vitamin A acid are discussed.
mesh_terms: D002145:Callosities / Q000188:drug therapy; D004485:Eczema / Q000188:drug therapy; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy* / Q000209:etiology; D008010:Lichen Planus / Q000188:drug therapy; D008134:Long-Term Care; D009779:Occlusive Dressings; D009824:Ointments; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives*; D014802:Vitamin A Deficiency; D014860:Warts / Q000188:drug therapy
chemical_list: D009824:Ointments; D014801:Vitamin A; D014212:Tretinoin
vernacular_title: Lokale Vitamin-A-Säure-Therapie bei palmaren/plantaren Hyperkeratosen