[Local Schwartzman phenomenon in axenic rabbits].
Local Schwartzman phenomenon was produced by coli-endotoxin in all the germfree rabbits tested (11 in all) at the age of 102 to 135 days. Any kinds of natural antibodies were not detected in sera of the rabbits, which in fact were found to be agammaglobulinaemic in most cases, as revealed by immunoelectrophoresis. These facts suggested that the germfree rabbits utilized here had not been sensitized to bacterial endotoxins. From the results obtained here, it may be concluded that the existence of hypersensitivity to endotoxin is not necessary to the production of local Schwartzman phenomenon by bacterial endotoxin.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism; D004731:Endotoxins / Q000276:immunology / Q000494:pharmacology*; D004926:Escherichia coli; D005340:Fibrinogen / Q000378:metabolism; D005856:Germ-Free Life; D006386:Hemagglutination Tests; D007958:Leukocyte Count; D011817:Rabbits; D012867:Skin / Q000187:drug effects
D001798:Blood Proteins; D004731:Endotoxins; D005340:Fibrinogen; D003165:Complement System Proteins
Etude du phénomène de Schwartzman local chez le lapin axénique