[Effect of psychotropic preparations on the activity of transport ATPase of rabbit skeletal muscle sarcoplasmic reticulum].
The effect exerted by 5 groups of psychotropic agents on b activity of Ca, Mg-dependent ATP-ase of the sarcoplasmatic reticulum in the skeletal muscles of the rabbit and the transport of Ca2+ were looked into. The most profound inhibitory effect was found to be displayed by neuroleptics--phenothiazine derivatives with the piperazine ring in the side chain. Neuroleptics-butyrophenones produced a much less marked inhibitory action. Tricyclic antidepressants noticeably reduced the activity of the enzyme, while MAO inhibitors proved little effective in this respect. Tranquilizers--benzodiazepine derivatives--displayed a moderate inhibitory influence, while trioxazine turned out to be little active. The stimulants caffein, pentylene tetrazol (corazol), as well as high concentrations of lithium salts raised, whereas their low concentrations suppressed the activity of the enzyme. The inhibitory effect of psychotropic agents increased by as much s 11/2--2 times with regard to the enzyme preliminarily activated through incubation with ATP.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D003864:Depression, Chemical; D008274:Magnesium; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
D011619:Psychotropic Drugs; D000251:Adenosine Triphosphatases; D008274:Magnesium; D002118:Calcium
Vliianie psikhotropnykh preparatov na aktivnost' transportnoĭ ATF-asy sarkoplazmaticheskogo retikuluma skeletnykh myshts krolika