Furazolidone-pethidine interaction in rabbits.
1 The intravenous injection of pethidine in rabbits pretreated with furazolidone administered orally but not systemically resulted in severe interaction and fatal hyperpyrexia. 2 Treatment with rho-chlorophenylalanine, chloropromazine of cyproheptadine protected the rabbits against the furazolidone-pethidine interaction, while alpha-methyl-rho-tyrosine was ineffective. 3 5-Hydroxytryptophan produced a fatal hyperpyrexia in furazolidone pretreated rabbits. 4 Pretreatment of rabbits with 1,1,1-trichloro-2, 2-bis(rho-chlorophenyl)ethane (DDT) accelerated and enhanced the furazolidone-pethidine interaction, while oxytetracycline pretreatment completely prevented the interaction. 5 It is concluded that furazolidone-pethidine interaction might depend mainly on potentiation of the effects of 5-hydroxytryptamine in the CNS and that the transformation of furazolidone into an active monoamine oxidase inhibitor metabolite might occur mainly in the gut microflora in the gut lumen.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D003634:DDT / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D005664:Furazolidone / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008614:Meperidine / Q000009:adverse effects / Q000494:pharmacology*; D008781:Methyltyrosines / Q000494:pharmacology; D010118:Oxytetracycline / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D008781:Methyltyrosines; D003533:Cyproheptadine; D005664:Furazolidone; D008614:Meperidine; D006916:5-Hydroxytryptophan; D003634:DDT; D010134:Fenclonine; D002746:Chlorpromazine; D010118:Oxytetracycline