Endotoxic activity of complexes of myristic acid and proteins.
Complexes of myristic acid and bovine serum albumin, myristic acid and concanavalin A, beta-hydroxymyristic acid and concanavalin A, or dimethyl myristamide and concanavalin A are lethal for male BALB/c mice treated with mithramycin. Prior treatment of mice with myristic acid-protein complexes renders the animals resistant to a dose of bacterial endotoxin that is lethal for untreated animals. Prior treatment of mice with bacterial endotoxin renders them resistant to a combination of mithramycin and a complex of myristic acid and bovine serum albumin or dimethyl myristamide and concanvalin A that is lethal for untreated animals. These data indicate that a fatty acid is an important functional component of the endotoxin toxophore.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology* / Q000627:therapeutic use; D004731:Endotoxins / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009227:Myristic Acids / Q000627:therapeutic use / Q000633:toxicity*; D008926:Plicamycin / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology / Q000627:therapeutic use; D012772:Shock, Septic / Q000209:etiology / Q000517:prevention & control; D013329:Structure-Activity Relationship
D004731:Endotoxins; D009227:Myristic Acids; D003208:Concanavalin A; D012710:Serum Albumin, Bovine; D008926:Plicamycin