title: A review and selection of simple laboratory methods used for the study of glycosaminoglycan excretion and the diagnosis of the mucopolysaccharidoses.
abstract: The current state of knowledge on the biochemical abnormalities in the mucopolysaccharidoses is reviewed. Methods for the estimation and identification of glycoasminoglycans excreted in the mucopolysaccharidoses are discussed and a selection of simple and reliable methods of value in a small hospital laboratory have been given in detail in an appendix.
mesh_terms: D001192:Arylsulfatases / Q000032:analysis; D011232:Chemical Precipitation; D002855:Chromatography, Thin Layer / Q000379:methods; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004588:Electrophoresis, Cellulose Acetate / Q000379:methods; D006025:Glycosaminoglycans / Q000302:isolation & purification / Q000378:metabolism / Q000652:urine*; D006603:Hexuronic Acids / Q000652:urine; D006801:Humans; D008403:Mass Screening; D009083:Mucopolysaccharidoses / Q000175:diagnosis* / Q000652:urine; D013048:Specimen Handling / Q000379:methods; D009626:Terminology as Topic
chemical_list: D006025:Glycosaminoglycans; D006603:Hexuronic Acids; D001192:Arylsulfatases