title: Effect of rhythmic alternation of protein depletion and repletion on the proportion and properties of haemoglobin in the rat.
abstract: The authors submit the results of a study of the effect of rhytmic alternation of protein depletion and repletion on the quantitative and qualitative proportion of haemoglobin in the rat. The results show that four weeks' depletion caused significant changes in the studied parameters, but that two weeks' repletion restored them to normal. The organism's responses to repeated depletion-repletion states were heterogeneous as regards the size, quality and trend of the changes, indicating that the organism's defences against depletion can be influenced by repeated administration in the form of a kind of "training". The mechanism of action of the above changes is at present still unknown.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002940:Circadian Rhythm; D004044:Dietary Proteins; D006454:Hemoglobins / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats
chemical_list: D001798:Blood Proteins; D004044:Dietary Proteins; D006454:Hemoglobins