[The effect of oxyfedrine, prenylamine and dipyridamole on heart hypertrophy and collagen concentration of pressure loaded rat hearts].
Rats were subjected to constriction of the abdominal aorta and two days later to nephrectomy. The maximum left ventricular hypertrophy was reached on the seventh day following the nephrectomy. During one month the animals were treated, six days per week with i.p. dipyridamole, prenylamine or oxyphedrine. The drugs studied suppressed the increase in hydroxyproline concentration of the left ventricle whereas the development of heart hypertrophy was not influenced.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000503:physiopathology*; D003094:Collagen / Q000378:metabolism*; D004176:Dipyridamole / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010099:Oxyfedrine / Q000494:pharmacology*; D011299:Prenylamine / Q000494:pharmacology*; D011312:Pressure; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats
D011427:Propiophenones; D004176:Dipyridamole; D003094:Collagen; D010099:Oxyfedrine; D011299:Prenylamine
Der Einfluss von Oxyfedrin, Prenylamin und Dipyridamol auf Herzhypertrophie und Kollagenkonzentration des druckbelasteten Rattenherzens