Catecholamines, blood pressure, renin and myocardial function in the spontaneously hypertensive rat.
1. Neither nerve-growth-factor antiserum (NGFAS) administered subcutaneously nor 6-hydroxydopamine administered intraventricularly to immature spontaneously hypertensive rats (SHR) inhibited the development of the hypertensive syndrome. In contrast, NGFSA did not affect blood pressure in normotensive Kyoto/Wistar rats. 2. Peripheral vascular resistance was increased and cardiac index decreased in both NGFAS and 6-hydroxydopamine-treated SHR despite preservation of normal blood pressure. 3 NGFAS treatment did not influence the development of left ventricular hypertrophy in SHR, despite the lowering of blood pressure. In contrast, 6-hydroxydopamine caused an attenuation in the development of left ventricular hypertrophy. 4. Indices of left ventricular contractility were depressed by NGFAS treatment but not by 6-hydroxydopamine. 5. Plasma renin activity was unaffected by NGFAS treatment and increased by 6-hydroxydopamine.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006332:Cardiomegaly / Q000209:etiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D006973:Hypertension / Q000150:complications*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009414:Nerve Growth Factors / Q000494:pharmacology; D051381:Rats; D013562:Sympathectomy; D014655:Vascular Resistance / Q000187:drug effects
D006892:Hydroxydopamines; D009414:Nerve Growth Factors