[Correlation between lactate output and insulin secretion of the isolated perfused rat pancreas under the influence of high concentrations of phenformin].
On the isolated perfused rat pancreas phenformin at high concentrations (10 mg/1, 50 mg/1 and 100 mg/1) provokes an increase of the insulin and lactate output in the effluent liquid. In no case is glucagon secretion modified by this substance. There exists a statistically significant correlations between the increase in insulin output and the increase in lactate output induced by phenformin.
D000818:Animals; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D010477:Perfusion; D010629:Phenformin / Q000494:pharmacology*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D007328:Insulin; D007773:Lactates; D010629:Phenformin
Corrélation entre le débit de lactate et la sécrétion d'insuline du pancréas isolé et perfusé du rat sous l'influence de fortes concentrations de phenformine