[A method of isolating inhibitors of the proliferative activity of liver hepatocytes].
A fraction containing two tissue specific regulators of the mitotic activity (chalone) and having a definite capacity to inhibit the DNA synthesis (G1-inhibitor) and to enter into the mitosis (G2-inhibitor) of hepatocytes of the regenerating liver was isolated from an aqueous extract by ethanol saturation from 70 to 81%. The fraction contains up to 10 substances of protein nature, 7 of which, due to the data of immunological analysis, are also present in other tissues and blood serum of rats.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D003864:Depression, Chemical; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D006133:Growth Substances / Q000302:isolation & purification* / Q000494:pharmacology; D007122:Immunoelectrophoresis; D008099:Liver / Q000032:analysis*; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D051381:Rats
D006131:Growth Inhibitors; D006133:Growth Substances; D004247:DNA
K metokike vydeleniia ingibitorov proliferativnoĭ aktivnosti gepatotsitov pecheni