[A comparative study in cultured rat liver cells of the metabolism of different analogues and metabolites of a natural hepatocarcinogen: safrol].
Metabolism by sexed rat liver cell lines of safrole, a natural hepatocancerogen and of metabolites and analogs were studied and compared by gas chromatography-mass spectrometry. The epoxide-diol route was evidenced for safrole, isosafrole and eugenol as well as the induction of drug metabolizing enzymes by tested compounds.
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002849:Chromatography, Gas; D004149:Dioxoles / Q000031:analogs & derivatives*; D008099:Liver / Q000378:metabolism*; D013058:Mass Spectrometry; D012451:Safrole / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D012737:Sex Factors
D004149:Dioxoles; D012451:Safrole
Etude comparative en culture cellulaire de foie de rat du métabolisme de différents analogues et métabolites d'un dépatocancérogène naturel: le safrol