[Multicenter clinical study of a novel steroid-free preparation in proctology].
In a multicentre study 15 physicians investigated the therapeutic efficacy and tolerance of Faktu suppositories and ointment (containing the active principle of Albothyl, a condensation product of m-cresolsulfonic acid and formaldehyde) in 585 patients with proctological affections. Highly satisfactory results were achieved in 486 patients (83.1%). The following were found to be the main indications: -treatment of wounds after proctological operations, -fresh and fissures, -bleeding internal haemorrhoids, -anal eczema and anal pruritus, -rhagades and perforated or prolapsed external haemorrhoids (perianal thrombosis). None of the investigators reported any persisting adverse side-effects. 16% of the patients complained of local discomfort of varying intensity such as pruritus, burning or irritation. The symptoms mostly appeared on commencement of the treatment and necessitated discontinuation of therapy in 5.3% only. The extremely favourable effect of Albothyl - the active principle of Faktu - is due to its unique mechanism of action: the markedly acid milieu of the substance. Furthermore the Faktu preparations do not contain any steroids and consequently they can be used without any misgivings over prolonged periods.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003408:Cresols / Q000009:adverse effects / Q000627:therapeutic use*; D003992:Dibucaine / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D003875:Drug Eruptions; D004341:Drug Evaluation; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy; D006484:Hemorrhoids / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011108:Polymers / Q000009:adverse effects / Q000627:therapeutic use; D011537:Pruritus / Q000139:chemically induced; D011538:Pruritus Ani / Q000188:drug therapy; D012002:Rectal Diseases / Q000188:drug therapy*; D013488:Suppositories; D014945:Wound Healing
D003408:Cresols; D004338:Drug Combinations; D009824:Ointments; D011108:Polymers; D013488:Suppositories; D003992:Dibucaine
Multizentrische klinische Prüfung eines neuen steroidfreien Präparates in der Proktologie