The chemotherapy of urologic cancer.
A review of the status of evaluation of chemotherapeutic agents in the urologic malignancies reveals a largely neglected area of investigation. Except for testicular carcinomas, which are highly responsive to drug therapy, active agents have not been clearly established for the other urogenital tumor sites. Published information and data on file in the Cancer Therapy Evaluation Program of the National Cancer Institute are reviewed, and studies currently in progress are outlined. Adequate clinical testing of the standard antitumor agents that are active against other human malignancies should receive high priority in future therapeutic trials in urologic cancer.
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D005467:Floxuridine / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use; D008926:Plicamycin / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy; D013852:Thiotepa / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000628:therapy; D014565:Urogenital Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D008937:Mitomycins; D005467:Floxuridine; D004958:Estradiol; D014750:Vincristine; D004317:Doxorubicin; D013852:Thiotepa; D008926:Plicamycin; D005472:Fluorouracil; D006918:Hydroxyurea; D008727:Methotrexate