A biochemical study of short-cycle manic-depressive psychosis in mental defectives.
Four mentally defective patients who were suffering from short-cycle manic-depressive psychosis were each studied under metabolic ward conditions for about six months. Weekly estimations of erythrocyte Na-K ATPase activity, ouabain sensitive potassium influx, sodium concentration, whole blood cell ATP concentration and blood haematocrit were made. The findings in each patient differed, but the erythrocyte Na-K ATPase activity, sodium and ATP concentration appeared to show cyclic changes related to, though out of phase with, the clinical state.
D000251:Adenosine Triphosphatases / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D001692:Biological Transport; D001693:Biological Transport, Active; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000378:metabolism*; D008094:Lithium / Q000627:therapeutic use; D010042:Ouabain; D010507:Periodicity; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014554:Urination
D010042:Ouabain; D000255:Adenosine Triphosphate; D008094:Lithium; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium