[Effects of thiamine pyrophosphate and sodium dichloroacetate on the increase of lactate and insulin outputs induced by phenformin on the isolated and perfused rat pancreas].
Thiamine pyrophosphate and sodium dichloroacetate, substances which promote the aerobic metabolism of pyruvate, reduce the increase in lactate output induced by phenformin (100 mg/l) on the isolated and perfused rat pancreas. Both substances provoke a decrease in insulin secretion produced by phenformin.
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010629:Phenformin / Q000494:pharmacology*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*
D000085:Acetates; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D003999:Dichloroacetic Acid; D010629:Phenformin; D013835:Thiamine Pyrophosphate
Effets de la thiamine pyrophosphate et du dichloro-acétate de sodium sur l'augmentation des débits de lactate et d'insuline provoquée par la phenformine sur le pancréas isolé et perfusé du rat.