[Role of the hydrophobicity of monoquaternary ammonium compounds in the mechanism of their curariform action].
The lengthening of the alkyl radical at the quaternary nitrogen atom (from -C2H5 to -C20H41) in the series of alkyltrimethylammonium compounds was found to lead to a gradually growing hydrophobicity of the compound. A change in the mechanism responsible for the myoparalytic action of the compound is due to a mounting degree of hydrophobicity. With the methyl group in the molecule of tetramethylammonium replaced with polyalicyclic radicals (bornyl, adamantyl) the compound, acting after a non-depolarizing type, possess a greater degree of hyrophobicity than do substances of the depolarizing type.
D000478:Alkylation; D000818:Animals; D002626:Chemistry, Pharmaceutical; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D010243:Paralysis / Q000139:chemically induced; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009125:Muscle Relaxants, Central; D003473:Neuromuscular Nondepolarizing Agents; D000644:Quaternary Ammonium Compounds
O roli gidrofobnosti monochetvertichnykh ammonievykh soedineniĭi v mekhanizme ikh kurarepodobnogo deĭstviia19h