[Effects of hydroxythiamine and citrate on several reactions of the pentose phosphate cycle and glycolysis].
Hydroxythiamin was shown to inhibite distinctly phosphofructokinase and phosphohexoisomerase besides a direct antivitaminous effect on transketolase. In this case the regulatory action is likely to be carried out by erythrose-4-phosphate, accumulating in liver tissue. Citrate (administered separately and together with hydroxythiamin) is assumed to influence indirectly the transketolase activity affecting the total regulation of carbohydrate metabolism.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002951:Citrates / Q000494:pharmacology*; D004347:Drug Interactions; D005956:Glucose-6-Phosphate Isomerase / Q000037:antagonists & inhibitors; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010119:Oxythiamine / Q000494:pharmacology*; D010428:Pentosephosphates / Q000378:metabolism*; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors
D002951:Citrates; D010428:Pentosephosphates; D013844:Thiazoles; D010119:Oxythiamine; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase; D010732:Phosphofructokinase-1; D005956:Glucose-6-Phosphate Isomerase
Osobennosti vliianiia oksitiamina i tsitrata na nekotorye reaktsii pentozofosfatnogo tsikla i glikoliza.