title: [The activity of aminotransferases in serum and cerebrospinal fluid in neurological diseases (author's transl)].
abstract: The activities of the aminotransferases, GOT and GPT, were determined in the serum and cerebrospinal fluid of patients with Parkinson's disease, Huntington's chorea, Wilson's disease, amyotrophic lateral sclerosis (ALS), Friedreich's ataxia, phenylketonuria, and head injuries. 1. In patients with Huntington's chorea the activity of SGOT was lower than in controls (P = 0.02); in Friedreich's ataxia LGPT activity was decreased (P less than 0.001); in patients suffering from ALS SGOT (P = 0.005), SGPT (P less than 0.001) and LGOT (P less than 0.001) activities were increased. 2. Long-term treatment of Parkinson's disease and Wilson's disease with L-dopa resulted in an increase in SGOT, LGOT, and SGPT activity over approximately 2 months, with subsequent normalization of these enzyme activities in spite of continued therapy. Guanidine treatment led to an increase in aminotransferase activities in patients with ALS. Penicillamine caused a decrease in SGOT and SGPT activities in Wilson's disease. These results illustrate the necessity of taking therapeutic measures into account in the interpretation of data on aminotransferase activities.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000134:cerebrospinal fluid; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology; D001219:Aspartate Aminotransferases / Q000097:blood / Q000134:cerebrospinal fluid; D006259:Craniocerebral Trauma / Q000201:enzymology; D005621:Friedreich Ataxia / Q000201:enzymology; D006146:Guanidines / Q000627:therapeutic use; D006527:Hepatolenticular Degeneration / Q000201:enzymology; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology; D007980:Levodopa / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000188:drug therapy / Q000201:enzymology*; D010300:Parkinson Disease / Q000201:enzymology; D010406:Penicillins / Q000627:therapeutic use; D010661:Phenylketonurias / Q000201:enzymology; D000637:Transaminases / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D006146:Guanidines; D010406:Penicillins; D007980:Levodopa; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Uber die Aktivität der Aminotransferasen in Serum und Liquor cerebrospinalis bei neurologischen Erkrankungen