Drug interactions with brain biogenic amines and the effects of amphetamine isomers on locomotor activity.
Administration of single IP doses of 1.0 or 4.0 mg/kg of d-amphetamine evoked an increase in mouse spontaneous motor activity (SMA); in contrast, 1.0 mg/kg of l-amphetamine had no significant effect, while 4.0 mg/kg caused a decreased SMA. Pretreatment with aMT or pargyline had little effect on the actions of the l-isomer, but reduced the magnitude and duration of the stimulatory effect of d-amphetamine. Pretreatment with p-chlorophenylalanine had little effect on the actions of d-amphetamine but completely abolished the depressant actions of the l-isomer. Reserpine pretreatment markedly reduced basal SMA levels; such pretreatment caused both d- and l-amphetamine to act as stimulants of SMA.
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000032:analysis; D010293:Pargyline / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis
D008781:Methyltyrosines; D012701:Serotonin; D012110:Reserpine; D010293:Pargyline; D000661:Amphetamine; D010134:Fenclonine; D003913:Dextroamphetamine; D009638:Norepinephrine