The role of cerebral 5-hydroxytryptamine for convulsive threshold and anticonvulsant effect of acetazolamide in rats.
The effect of various substances modifying the activity of serotoninergic system on convulsive threshold and anticonvulsant effect of acetazolamide (ACA) in rats was studied using the electric test. The obtained results are suggestive of 5-hydroxytryptamine (5-HT) playing a significant role for convulsive threshold. On the other hand, the changes in the potency of anticonvulsant effect of ACA resulting from administration of substances altering the level of cerebral 5-HT seems to be secondary to the effect of these substances on convulsive threshold. Additionally, the ACA doses being effective as anticonvulsant were found to increase the cerebral level of 5-hydroxyindoleacetic acid (5-HIAA) and to accelerate the 5-HT turnover.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D000086:Acetazolamide / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*
D008781:Methyltyrosines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012110:Reserpine; D000086:Acetazolamide; D010134:Fenclonine; D015115:5,6-Dihydroxytryptamine