title: Partial characterization of pepsins and gastricsins and their zymogens from human and toad gastric mucosae.
abstract: 1. Three zymogens have been isolated from human gastric mucosae and two from the stomachs of the toad Caudiverbera caudiverbera. 2. Human zymogens I and III were immunologically related and cross-reacted with antisera prepared against porcine pepsinogen. The third, (II), showed no cross-reactivity. 3. Human zymogens I and III and toad zymogen ZII gave rise to two human pepsins and to a pepsin-like enzyme, respectively. 4. Human zymogen II (gastricsinogen) and toad zymogen ZI gave rise to human gastricsin and to a gastricsin-like enzyme respectively. 5. The toad enzymes showed much greater stability at neutral and alkaline pH values than the human enzymes.
mesh_terms: D000818:Animals; D002025:Bufonidae / Q000378:metabolism*; D004792:Enzyme Precursors / Q000032:analysis*; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D010434:Pepsin A / Q000032:analysis*
chemical_list: D004792:Enzyme Precursors; D010434:Pepsin A; C020557:gastricsin