[Cerebrospinal fluid metabolism of biogenic amines in Huntington chorea].
CSF metabolites of dopamine (HVA), norepinephrine (MHPG) and serotonine (5HIAA) in 9 patients affected by Huntington's Chorea before and after therapy with phenotiazine derivatives (Fluphenazine) have been studied. A close relationship seems to exist between therapeutical results and CSF HVA modifications: improvement of choreatic movements is associated with marked increase in CSF HVA values. Biochemical bases of Huntington's Chorea are discussed.
D000328:Adult; D000368:Aged; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D004298:Dopamine / Q000134:cerebrospinal fluid; D005260:Female; D005476:Fluphenazine / Q000627:therapeutic use; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D012701:Serotonin / Q000134:cerebrospinal fluid
D001679:Biogenic Amines; D012701:Serotonin; D005476:Fluphenazine; D004298:Dopamine; D009638:Norepinephrine
Rilievi sul metabolismo liquorale delle amine biogene nella Corea di Huntington