Lithium metabolism and intracellular electrolytes.
Lithium chloride was administered orally to swine and two different types of sheep, HK and LK. There was a pre-lithium 16-fold variation in intracellular sodium (LK greater than HK greater than swine) and a 6.5-fold variation in the intracellular potassium (swine greater than HK greater than LK). Collected plasma and erythrocytes were analyzed for lithium, sodium and potassium. The ratio of erythrocyte lithium/plasma lithium was directly related to the pre-lithium erythrocyte sodium concentration and inversely related to the pre-lithium erythrocyte potassium concentration.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D008094:Lithium / Q000378:metabolism*; D012756:Sheep; D013552:Swine
D001679:Biogenic Amines; D004573:Electrolytes; D008094:Lithium