title: Lysine catabolism in Rhizoctonia leguminicola and related fungi.
abstract: The catabolism of lysine was studied in several yeasts and fungi. Results with cell-free extracts of Rhizoctonia leguminicola support a proposed pathway involving (D- and L-) EPSILON-N-acetyllysine, alpha-keto-epsilon-acetamidohexanoic acid, delta-acetamidovaleric acid, and delta-aminovaleric acid in the conversion of L-lysine to shortchain organic acids. Label from radioactive L-lysine was found to accumulate in D- and L-epsilon-N-acetyllysine, delta-acetamidovaleric acid, delta-aminovaleric acid, and glutaric acid in cultures of R. leguminicola, Neurospora crassa, Saccharomyces cerevisiae, and Hansenula saturnus, suggesting that the proposed omega-acetyl pathway of lysine catabolism is generalized among yeasts and fungi. In N. crassa, as is the case in R. leguminicola, the major precursor of L-pipecolic acid was the L-isomer of lysine; 15N experiments were consistent with delta1-piperideine-2-carboxylic acid as an intermediate in the transformation.
mesh_terms: D002208:Caproates / Q000378:metabolism; D002474:Cell-Free System; D005658:Fungi / Q000378:metabolism*; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000378:metabolism*; D009492:Neurospora crassa / Q000378:metabolism; D010843:Pichia / Q000378:metabolism; D010875:Pipecolic Acids / Q000378:metabolism; D012232:Rhizoctonia / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013237:Stereoisomerism; D014631:Valerates / Q000378:metabolism
chemical_list: D002208:Caproates; D010875:Pipecolic Acids; D014631:Valerates; D008239:Lysine