Evaluation of RX 72601 as an anti-curare agent.
RX 72601, a new and potent anticholinesterase, has been evaluated for its ability to reverse the neuromuscular blockade induced by non-depolarizing muscle relaxants. In rats RX 72601 10 mug/kg i.v. proved effective in reversing the effects of alcuronium gallamine, pancuronium or tubocurarine and the drug exhibited a wide margin of safety. RX 72601 proved equally effective in reversing the effects of tubocurarine in both cats and baboons. In dogs and cats, effective anti-curare doses had little action on the cardiovascular or respiratory systems. Overall the results obtained indicate that RX 72601 may be a safe antagonist of non-depolarizing muscle relaxants and that it will be possible to use RX 72601 without prior administration of atropine.
D000818:Animals; D001158:Arteries / Q000187:drug effects; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003510:Cyclohexanes / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005703:Gallamine Triethiodide / Q000037:antagonists & inhibitors; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors; D010197:Pancuronium / Q000037:antagonists & inhibitors; D010215:Papio; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D012119:Respiration / Q000187:drug effects; D014117:Toxiferine / Q000037:antagonists & inhibitors; D014403:Tubocurarine / Q000037:antagonists & inhibitors
D003510:Cyclohexanes; D003473:Neuromuscular Nondepolarizing Agents; D011759:Pyrrolidines; D001285:Atropine; D014117:Toxiferine; D010197:Pancuronium; D005703:Gallamine Triethiodide; D014403:Tubocurarine