title: [Pharmacological characteristics of a new curariform compound from a series of naphthalene-peri-tetracarboxylic acid derivatives].
abstract: Experiments staged with rabbits, cats, frogs and chicken have proved tetracarboxylic acid dibenzosulphoethylate-bis (para-piperidinophenol)-diimidonaphthalene-1, 4, 5, (see article) to be capable of totally blocking the neuro-muscular conduction in a dose of 0.5 mg/kg and to block 20 per cent of it in a dose of 0.3 mg/kg. The action of the compound on the arterial pressure is half as great as that of d-tubocurarine. A pharmacological analysis conducted on the musculus rectus abdominus of the frog and chicken points to an antidepolarizing type of action. The durarolike effect of (see article) can be averted or abolished by introduction of nivalin (galanthamine), proserine and pimadine. The author deems it expedient to make clinical trials of the drug.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D002415:Cats; D004347:Drug Interactions; D005702:Galantamine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009281:Naphthalenes / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009388:Neostigmine / Q000494:pharmacology; D009431:Neural Conduction / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010880:Piperidines / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects
chemical_list: D009281:Naphthalenes; D003473:Neuromuscular Nondepolarizing Agents; D010880:Piperidines; D011725:Pyridines; D011950:Receptors, Cholinergic; D005702:Galantamine; D009388:Neostigmine; D000109:Acetylcholine
vernacular_title: Farmakologicheskaia kharakteristika novogo kurarepodobnogo soedineniia izriada proizvodnykh naftalin-peri-tetrakarbonovoĭ kisloty