[Effect of nicotine on insulin secretion in the isolated perfused rat pancreas].
Insulin secretion induced by glucose (1.5 g/l) is changed by nicotine infusion; the recorded changes depend on the nicotine concentration uses. 1) At a low concentration (0.05 mM) nicotine provokes an immediate, progressively increasing and lasting stimulation of insulin secretion. This stimulation is inhibited by hexamethonium (0.1 mM) and atropine (0.3 micrometer). 2) At a high concentration (1 mM) nicotine has a triphasic effect on insulin secretion : brief decrease, peak of stimulation and prolonged decrease. Hexamethonium decreases the stimulation and suppresses the prolonged inhibition.
D000818:Animals; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D009538:Nicotine / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D051381:Rats
D006584:Hexamethonium Compounds; D007328:Insulin; D009538:Nicotine
Effets de la nicotine surla sécrétion d'insuline du pancréas isolé et perfusé du rat.