[The effect of 4-aminopyridine of the synaptic activity in the last abdominal ganglion of the cockroach (Periplaneta americana)].
Synaptic action of 4-aminopyridine (4-AP) has been studied in the sixth abdominal ganglion of the cockroach. Our results show that 4-AP has a strong excitatory effect on the ganglion and its seems that it depolarizes as well the pre and postsynaptic membranes. The threshold concentration is about 10(-5) M.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005724:Ganglia / Q000187:drug effects*; D005731:Ganglionic Stimulants; D008564:Membrane Potentials / Q000187:drug effects; D010526:Periplaneta; D011725:Pyridines / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
D005731:Ganglionic Stimulants; D011725:Pyridines
Modifications par la 4-aminopyridine de l'activité synaptique au niveau du dernier ganglion abdominal de la Blatte (Periplaneta americana)