Modelling of hypertrophic heart potentiation with reference to morphological measurements.
Potentiation of heart muscle stripes of the right ventricle was investigated in normal rats (NT-group) and in rats stressed by swimming (HT-group). The mean fibre diameter runs to 26 micrometer in HT-group and 16 micrometer in NT-group. The difference was significantly high, as well as that of relative heart weights. The potentiation by paired pulse stimulation was more marked in HT-group than in NT-group. The interval-strength-relationships increase with prolongation of the driving interval. Potentiation is greater in loaded rats than in normal rats. A mathematical model for Ca++-storage in sarcoplasmic reticulum is introduced. Decrease of basic-filling of Ca++-store is modelled to HT-group with support of morphological measurements and is discussed as reason for improved properties of potentiation of HT-group.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology; D006332:Cardiomegaly / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D008297:Male; D008954:Models, Biological; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D011199:Potentiometry; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000502:physiology
D002118:Calcium