title: [Comparative evaluation of studies of the action of different levels of hypoxia on the human immunobiological status].
abstract: The effect of hypoxic hypoxia on the specific factors of immunity of 16 test subjects was studied during their 30-day exposure to an altitude of 2100-4200 m above the sea level in the area of the Elbrus mountain. In order to differentiate the effect of hypoxia per se from that of other factors typical of highlands, five runs of altitude chamber experiments were carried out. In each run the test subjects were 10 times lifted to altitudes of 3200 m, 4200 m and 5200 m. The chamber experiments were performed on 28 test subjects, aged 26-46. During an exposure to an altitude the test subjects did two or three times exercises of 450-900 kgm/min on a bicycle ergometer. The experimental findings show that hypoxic hypoxia brings about consistent changes in the immunobiological status of man that are directly correlated with the level of hypoxia. These changes include a decline in the acquired antiviral and antitoxic immunity activation of the autoimmune process and an increase in the phagocytic activity of neutrophils. Our results suggest optimal profiles of the hypoxic effect to which test subjects should be exposed during mountain training for a specific occupational activity.
mesh_terms: D000064:Acclimatization; D000328:Adult; D000531:Altitude; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D000989:Antistreptolysin / Q000032:analysis; D001273:Atmosphere Exposure Chambers; D001323:Autoantibodies; D006801:Humans; D000860:Hypoxia / Q000276:immunology*; D007109:Immunity; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D009031:Moscow; D009975:Orthomyxoviridae / Q000276:immunology; D012426:Russia; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D001323:Autoantibodies; D000989:Antistreptolysin
vernacular_title: Sravnitel'naia otsenka issledovaniĭ deĭstviia razlichnogo urovnia gipoksii na immunobiologicheskiĭ status cheloveka