title: [Biochemistry and function of glycosaminoglycans of the skin].
abstract: The basic defects of a number of genetic disorders affecting the connective tissue have been elucidiated during the last few years. A similar progress in understanding the pathobiochemistry of other dermatological diseases is expected. The present review summarizes our knowledge about structure, synthesis, degradation, macromolecular organization and possible function of glycosaminoglycans, which are an important constitutent of the ground substance in the skin. The difficulties of relating the clinical symptoms of diseases with the basic defects are examplified for the mucopolysaccharidoses.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D055598:Chemical Phenomena; D002621:Chemistry; D002809:Chondroitin Sulfates / Q000032:analysis; D003871:Dermatan Sulfate / Q000032:analysis; D057487:Enzyme Therapy; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D006025:Glycosaminoglycans / Q000032:analysis* / Q000096:biosynthesis; D006497:Heparan Sulfate / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D007231:Infant, Newborn; D008875:Middle Aged; D009083:Mucopolysaccharidoses / Q000188:drug therapy / Q000378:metabolism; D011247:Pregnancy; D011509:Proteoglycans / Q000032:analysis; D012867:Skin / Q000032:analysis*
chemical_list: D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D006820:Hyaluronic Acid; D011509:Proteoglycans
vernacular_title: Biochemie und Funktion der Glykosaminoglykane der Haut