title: Effect of tryptaminergic drugs on electroshock fighting behaviour in rats.
abstract: The effect of some tryptaminergic drugs on electroshock fighting behaviour in rats was determined. Reserpine and tetrabenazine reduced the fighting responses while 5-hydroxytryptophan increased the fighting responses in normal as well as reserpine-treated animals. p-Chlorophenylalanine, a specific depletor of brain serotonin, also reduced the fighting responses. The results suggest that an increase of brain serotonin may have a facilitatory effect on electroshock fighting behaviour and a decrease of brain serotonin may impair fighting behaviour.
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004597:Electroshock; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis*; D013747:Tetrabenazine / Q000494:pharmacology
chemical_list: D012701:Serotonin; D012110:Reserpine; D006916:5-Hydroxytryptophan; D010134:Fenclonine; D013747:Tetrabenazine