title: Fetal lung lecithin metabolism in the glucose-intolerant Rhesus monkey pregnancy.
abstract: Fetal lung lecithin metabolism was examined in rhesus monkey gestations complicated by glucose intolerance secondary to maternal streptozotocin (STZ) administration. Fetuses of STZ-treated mothers were delivered at 85% to 89% of term and were compared to two control groups of fetuses from normal pregnancies--one group age-matched to the STZ pregnancies, and the other composed of fetuses delivered in the final 10% of gestation. In the glucose-intolerant pregnancies, two measures of fetal lung lecithin biosynthesis--the amniotic fluid lecithin-to-sphingomyelin (L/S) ratio and the rate of 14C-choline incorporation into lecithin in fetal lung slices--were significantly greater than in age-matched normal gestations and were similar to results in late-gestation controls. However, lung lecithin concentrations in the glucose-intolerant group were comparable to the age-matched controls, and both were significantly less than in the late-gestation controls. Since the gestational age, mode of delivery, and fetal acid-base status were the same in the age-matched groups, we conclude that these changes in fetal lung lecithin metabolism are due to the effects of maternal glucose intolerance.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D005260:Female; D005313:Fetal Death; D005333:Fetus / Q000378:metabolism*; D005951:Glucose Tolerance Test; D000882:Haplorhini; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000378:metabolism*; D008253:Macaca mulatta; D010713:Phosphatidylcholines / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000139:chemically induced; D013109:Sphingomyelins / Q000378:metabolism; D013311:Streptozocin
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins; D013311:Streptozocin