Further studies on the major histocompatibility complex as a genetic marker for schizophrenia.
Our results seem to indicate the existence of a locus in the major histocompatibity complex (MHC) region, correlated to schizophrenic illness and strictly linked to the loci HL-A and MLR. The associations found between these last loci and the disease can probably be explained by a linkage disequilibrium or a selective pressure between the allelles of the three loci. Our results also indicate that the genetic systems investigated may be useful diagnostically as a genetic marker for schizophrenia. But the real meaning of their relationships to the illness has to be further investigated.
D000483:Alleles; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000032:analysis; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012562:Schizophrenia, Disorganized / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000235:genetics
D006680:HLA Antigens; D006649:Histocompatibility Antigens