[Polymer linked N-(hexyl)-5-azido-2-nitro-benzoic acid amide; a photoreactive resin for the immobilization of ligands (author's transl)].
The preparation of a new photochemically-activatable polymer was accomplished by condensation of aminohexyl-6-yl-agarose with the N-hydroxysuccinimide ester of 5-azido-2-nitro-benzoic acid. The latter compound was obtained by diazotization of 5-amino-2-nitro-benzoic acid, exchange of the diazonium group through azide and condensation with N-hydroxysuccinimide. As shown for the photolysis on the monomer level, irradiation of the polymer led to the intermediate formation of a highly reactive nitrene, which is able to immobilize ligands e. g. L-phenylalanine to the polymer.
D001386:Azides / Q000138:chemical synthesis*; D008024:Ligands / Q000302:isolation & purification*; D009579:Nitrobenzoates / Q000138:chemical synthesis*; D010649:Phenylalanine / Q000302:isolation & purification; D010777:Photochemistry; D011108:Polymers
D001386:Azides; D008024:Ligands; D009579:Nitrobenzoates; D011108:Polymers; D010649:Phenylalanine
Polymergebundenes N-(Hexyl)-5-azido-2-nitro-benzoesäureamid; ein photoreaktiver Träger zur Immobilisierung von Liganden