[Factors influencing transduction of genetic determinants of penicillinase activity and pathogenicity in staphylococcus aureua. II. Antiphage activity of acridine derivatives].
Acridine dyes examined earlier (acrichine, acridine orange, proflavine and rivanol) and newly-synthesized preparations (acridines No. No. 37--40) were studied in the capacity of nonspecific agents influencing the lytic cycle in development of staphylococcus phages. Acrichine and acridine No. 37 failed to prevent lysis of the indicator staphylococcus cultures (strains 16/160 and 8325) by bacteriophages; proflavine, rivanol, acridines No. No. 39--40 produced a marked inhibitory effect; acridine orange and acridine No. 38 inhibited the staphylococcus lysis completely. Some preparations could be used to investigate the transduction phenomenon.
D000166:Acridines / Q000494:pharmacology*; D008242:Lysogeny / Q000187:drug effects*; D010405:Penicillinase / Q000378:metabolism*; D013210:Staphylococcus / Q000201:enzymology / Q000472:pathogenicity*; D013204:Staphylococcus Phages / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013997:Time Factors; D014774:Virulence
D000166:Acridines; D010405:Penicillinase
Faktory, vliiaiushchie na transduktsiiu geneticheskikh determinantov penitsillinaznoĭ aktivnosti i patogennosti u zolotistogo stafilokokka. Soobshchenie II. Antifagovaia aktivnost' proizvodnykh akridina