The influence of serotonergic agents on the body temperature.
The effects of serotonin precursors, tryptophan (TP) and L-5-hydroxytryptophan (5-HTP), administered together with peripheral decarboxylase inhibitor -- Ro 4-4602 on the rectal body temperature of rats was studied. TP caused a significant hypothermia which was prevented by pretreatment with p-chlorophenylalanine (PCPA), the serotonin synthesis inhibitor. 5-HTP did not influence the body temperature or slightly decreased it. However, the significant hypothermizing effect of 5-HTP was observed in rats pretreated with spiroperidol, haloperidol or phenoxybenzamine. Methysergide or cyproheptadine -- compounds regarded as potent serotonin receptor blockers -- did not prevent the TP-induced hypothermia. In methysergide pretreated rats 5-HTP produced a considerable hyperthermia. Cyproheptadine did not influence the effects of 5-HTP on the body temperature. The results obtained suggest that cyproheptadine and methysergide fail to block those central serotonin receptors which produce hypothermia after their stimulation.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D013134:Spiperone / Q000494:pharmacology; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology
D010643:Phenoxybenzamine; D003533:Cyproheptadine; D012701:Serotonin; D013134:Spiperone; D001545:Benserazide; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D010134:Fenclonine; D008784:Methysergide