Intra-erythrocytary enzymes before and after splenectomy.
The activity of the intraerythrocytary enzymes glucose-6-phosphate dehydrogenase, pyruvate kinase, glutathione reductase and ATPase was measured before and after splenectomy in 13 patients with congenital hemolytic anemia and 3 patients suffering from chronic thrombocytopenia. All patients were treated successfully, as reflected by clinical and basal hematological parameters. Glucose-6-phosphate dehydrogenase and pyruvate kinase were significantly depressed after splenectomy. It was not possible to set up prognostic criteria of splenectomy from the intraerythrocytary enzymes.
D000251:Adenosine Triphosphatases / Q000097:blood; D000328:Adult; D000367:Age Factors; D000745:Anemia, Hemolytic, Congenital / Q000201:enzymology* / Q000628:therapy; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D011770:Pyruvate Kinase / Q000097:blood; D013103:Spherocytosis, Hereditary / Q000201:enzymology; D013156:Splenectomy; D013921:Thrombocytopenia / Q000201:enzymology* / Q000628:therapy
D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D011770:Pyruvate Kinase; D000251:Adenosine Triphosphatases