Effect of lithium on brain 5-hydroxytryptamine metabolism in mice.
Administration of lithium carbonate (2 mEq/kg) i.p., twice daily for 3 days to mice did not significantly after brain 5-hydroxytryptamine (5-HT) levels; however, brain 5-hydroxyindoleacetic acid (5-H1AA) accumulation after i.p. injection of probenecid (200 mg/kg) was significantly increased in lithium pretreated animals. Brain 5-hydroxytryptophan decarboxylase activity was enhanced by lithium pretreatment while brain monoamine oxidase (MAO) activity was unaltered. After i.p. injection of the monoamine oxidase inhibitor pargyline (100 mg/kg) the accumulation of brain 5-HT was greater in lithium treated than control mice, while the decrease in brain 5-HT levels after i.p. treatment with the 5-HT synthesis inhibitor para-chlorophenylalanine (PCPA 300 mg/kg) was significantly less in lithium pretreated mice.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002262:Carboxy-Lyases / Q000378:metabolism; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008094:Lithium; D010293:Pargyline; D008995:Monoamine Oxidase; D002262:Carboxy-Lyases; D011339:Probenecid; D010134:Fenclonine