A quantitative model of venous stasis thrombosis in rats.
A quantitative model of stasis-type of venous thrombosis in rats is described. The ligated bowel loop was used after provocation by an injection of kaolin. The mesenteric vessels of the loop were cut in a dish filled with distilled water and the extinction of escaped haemoglobin was measured photometrically. Heparin was highly effective in this model. Vessel wall lesion may be used or inducing thrombosis instead of kaolin.
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D006454:Hemoglobins / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use; D007616:Kaolin; D008026:Ligation; D051381:Rats; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*
D006454:Hemoglobins; D007616:Kaolin; D006493:Heparin