Etiology of postobstructive diuresis: ouabain-sensitive adenosine triphosphatase deficit and elevated solute excretion in the postobstructed dog kidney.
A selective deficit in ouabain-sensitive adenosine triphosphatase has been shown in unilaterally obstructed dog kidneys; the deficit correlates inversely with Na+ and K+ excretion following relief of obstruction. It is postulated that the enzymatic defect may play a role in the etiology of postobstructive diuresis.
D000251:Adenosine Triphosphatases / Q000172:deficiency*; D000328:Adult; D000368:Aged; D000818:Animals; D004231:Diuresis; D004285:Dogs; D005260:Female; D006801:Humans; D007668:Kidney / Q000201:enzymology / Q000503:physiopathology*; D008875:Middle Aged; D011188:Potassium / Q000652:urine*; D012964:Sodium / Q000652:urine*; D014517:Ureteral Obstruction / Q000503:physiopathology*
D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium