Origin of stress macroreticulocytes from macronormoblasts.
Stress erythropoiesis was induced in rats and guinea-pigs by graded amounts of bleeding and phenyl-hydrazine administration. Hemoglobin and DNA content was measured by microspectrophometry of single erythroblasts in the process of nuclear extrusion. DNA content was always 2 C. Hemoglobin content was in all cases superior to the normal value, occasionally reaching a value of almost twice normal.
D000818:Animals; D001854:Bone Marrow Cells; D004247:DNA / Q000032:analysis; D004900:Erythroblasts / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology; D006168:Guinea Pigs; D006454:Hemoglobins / Q000032:analysis; D010659:Phenylhydrazines / Q000494:pharmacology; D051381:Rats; D012156:Reticulocytes / Q000187:drug effects*
D006454:Hemoglobins; D010659:Phenylhydrazines; D004921:Erythropoietin; D004247:DNA