Dose response in vivo to digoxin in normo-and hyperkalaemia: associated biochemical changes.
The effect of digoxin, at two different inotropic levels, was examined in normo- and hyperkalaemic dogs. For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na+, K+)-ATPase inhibition and microsomal-bound digoxin.
D000251:Adenosine Triphosphatases / Q000032:analysis / Q000037:antagonists & inhibitors*; D000818:Animals; D004077:Digoxin / Q000097:blood / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000032:analysis; D006947:Hyperkalemia / Q000503:physiopathology*; D008861:Microsomes / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D011188:Potassium / Q000097:blood; D012964:Sodium
D004077:Digoxin; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium