Topical vitamin A acid in the treatment of acne vulgaris (a controlled multicenter trial).
A controlled non-blind multicenter trial was conducted in 211 acne patients to test the activity of topical retinoic acid against sulfur-resorcinol--salicylic acid and placebo. Uniform evaluation criteria were used. After 8 weeks' treatment in comparable groups of patients, retinoic acid proved to be superior to the standard and to the placebo. The difference was statistically significant. Side effects were present in a number of patients treated with the active substances and with the placebo (mainly erythema), but rarely was the treatment discontinued.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D012118:Resorcinols / Q000627:therapeutic use; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives*
D010919:Placebos; D012118:Resorcinols; D014801:Vitamin A; D014212:Tretinoin