[ATPase activity and processes of calcium transport in membranes of sarcoplasmic reticulum of skeletal muscles with E-avitaminotic dystrophy].
Peculiarities of functioning of the sarcoplasmic reticulum muscles membranes with E-avitaminotic distrophy were studied. It was determined that the level of ATP-dependent consumption of Ca2+, value of the Mg2+, Ca2+-ATPase activity and an amount of the intermediate phosphorylated product forming in the reaction of ATP hydrolysis decrease. The rate of this product formation in the sarcoplasmic reticulum of the distrophic muscles is inhibited as compared to normalcy. Elimination of Ca2+ into calcium-free medium from the vesicular membranes of the reticulum preliminarily loaded with Ca2+ occurs more rapidly under dystrophy than in normalcy. The data obtained evidence for a disturbance of mechanism of Ca2+ active transport and for an increase in the membrane permeability for Ca2+ in the membranes of the dystrophic muscles sarcoplasmic reticulum. A problem is considered on a dependence of the skeletal muscles observed in the reticulum under dystrophy of the functional changes on the membrane structure, in particular on their lipid composition.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D008566:Membranes / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000209:etiology / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000150:complications / Q000378:metabolism*
D000251:Adenosine Triphosphatases; D008274:Magnesium; D002118:Calcium
Mg 2+, Ca 2+--ATPaznaia aktivnost' i protsessy transporta kal'tsiia v membranakh sarkoplazmaticheskogo retikuluma skeletnykh myshts pri E-avitaminoznoĭ distrofii.