title: The role of human endothelial cells in allograft rejection. Some in vitro correlates.
abstract: Endothelial cells, separated from the inside of the umbilical vein by collagenase digestion, could clearly stimulate allogeneic lymphocytes to blastogenesis and increased DNA synthesis in mixed lymphocyte endothelial-cell cultures. Many of the characteristics of these mixed cultures were similar to those found in mixed cultures consisting exclusively of allogeneic lymphoid cells; the MLC response. Endothelial cells could also be destroyed in vitro by cells sensitized in mixed lymphocyte cultures. When incubated in the presence of specific HL-A antisera, they were destroyed in non-immune peripheral blood mononuclear cells. These three reactions are thought to be in vitro correlated to some of the events taking place following allografting in vivo.
mesh_terms: D000906:Antibodies; D004727:Endothelium / Q000166:cytology* / Q000276:immunology; D006084:Graft Rejection; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D000906:Antibodies