title: Effect of intrahepatically implanted islets of Langerhans on hepatic function in the rat.
abstract: Diabetes mellitus is satisfactorily controlled in the rat by hepatic implantation of isolated, isologous pancreatic islets.  The transplanted islets appear to be viable for at least 6 months after implantation, and hepatic function studies (serum bilirubin, alkaline phosphatase, glutamic-oxalacetic transaminase, prothrombin time) and microscopic examination indicate that they do not interfere with hepatic function.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D016381:Islets of Langerhans Transplantation; D008099:Liver / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013311:Streptozocin; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D001786:Blood Glucose; D013311:Streptozocin; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase