Effect of levamisole (NSC-177023) on DNA synthesis by lymphocytes from immunosuppressed C57BL mice.
The effect of in vivo treatment of C57BL mice with BCNU and/or levamisole on the in vitro DNA synthetic capacity of their spleen cells was studied as a measure of cell-mediated immune function. BCNU treatment was suppressive to spleen cell DNA synthesis; conversely, treatment with levamisole was stimulatory. Levamisole treatment 5-8 days after BCNU treatment resulted in significant recovery of DNA synthetic capacity. Multiple doses of levamisole were not more effective than single doses. Allogeneic stimulation of BCNU-suppressed lymphocytes was not consistently increased by levamisole treatment.
D000818:Animals; D002330:Carmustine / Q000494:pharmacology; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology
D007978:Levamisole; D004247:DNA; D002330:Carmustine