[Effect of rat liver chalones on liver cell proliferation at different times after partial hepatectomy].
The action of rat's liver ethanol extract (72--81 per cent saturation) on cell proliferation of this organ at various periods after a partial hepatectomy has been studied. The most sensitive periods of the action of G1- and G2-chalone were, resp., the time of cell transformation, and the middle of the premitotic period of cell cycle. The action of G2-chalone used is organ-specific, since the drug decreased the mitotic activity of both hepatocytes and stromal cells. At the same time, the proliferation of ear, tongue and small bowel epithelial cells remained unchanged.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009928:Organ Specificity; D051381:Rats; D013997:Time Factors
D006131:Growth Inhibitors; D004247:DNA
Osobennosti vliianiia keĭlonov pecheni krys na proliferatsiiu kletok pecheni v razlichnye sroki posle chastichnoĭ gepatéktomii.