title: Alaskan malamute chondrodysplasia. II. Urinary excretion of hydroxyproline, uronic acid and acid mucopolysaccharides.
abstract: The urinary excretion of free, total and non-dialyzable hydroxyproline appeared to be similar in both chondrodysplastic and non-chondrodysplastic Alaskan Malamutes of ages six and twenty-six weeks suggesting the metabolic defect was probably not related to a gross disturbance in collagen metabolism. Urinary hexuronic acids also appeared to be similar in levels for both populations. A four-fold increase in urinary mucopolysaccharide levels observed at age twenty-six weeks in the chondrodysplastic Alaskan Malamute suggested a deviation from normal. The magnitude and variability of deviation were not sufficient to indicate that this condition could serve as a model for the mucopolysaccharidosis of man but probably indicated a delayed maturation process.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000652:urine*; D004285:Dogs; D006025:Glycosaminoglycans / Q000378:metabolism / Q000652:urine*; D006909:Hydroxyproline / Q000378:metabolism / Q000652:urine*; D010009:Osteochondrodysplasias / Q000175:diagnosis / Q000378:metabolism / Q000652:urine*; D014574:Uronic Acids / Q000378:metabolism / Q000652:urine*
chemical_list: D006025:Glycosaminoglycans; D014574:Uronic Acids; D006909:Hydroxyproline