Effect of deoxycorticosterone acetate and 16beta-hydroxy-dehydroepiandrosterone on blood pressure and plasma renin activity of rats.
Intact female Sprague-Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16beta-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16beta-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000033:anatomy & histology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012083:Renin / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D003900:Desoxycorticosterone; D003687:Dehydroepiandrosterone; D012083:Renin