title: [Medico-genetic study of the population of Uzbekistan. III. Phenotypical assortativity as a factor in population structure (using palmoplantar hyperkeratosis and vitiligo as examples)].
abstract: The article comprises the examples of homophenogamic marriages between persons with a rare hereditary dominant character, hand-palm and foot-sole hyperkeratosis, leading to the increase of inbreeding intensity in the population. On the contrary, homophenogamic marriages between persons with vitiligo, a considerably more widespread character, lead to the decrease of the degree of inbreeding in a population, since they take place between partners coming from different districts of the region.
mesh_terms: D005260:Female; D005828:Genetics, Population; D006801:Humans; D007178:Inbreeding; D007645:Keratoderma, Palmoplantar / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014610:Uzbekistan; D014820:Vitiligo / Q000453:epidemiology / Q000235:genetics*
vernacular_title: Mediko-geneticheskoe izuchenie naseleniia Uzbekistana. Soobshchenie III. Fenotipicheskaia assortativnost' kak faktor populiatsionnoĭ struktury (na primere ladonno-podoshvennogo giperkeratoza i vitiligo).