[Half-life of dehydroepiandrosterone sulfate (DHAS) during pregnancy].
During pregnancy the half-life of DHAS was measured after non tritiated DHAS infusion. At 30 weeks, the mean value obtained for DHAS half-life was 3.64 h +/- 0.74 and it was 3.67h +/- 0.38 at 38 weeks. The half-life of DHAS is shorter in pregnant than in non-pregnant women. Among 14 pathological pregnancies that we studied, 13 cases exhibited a DHAS half-life significantly longer than the average value obtained in normal pregnancies. In retarded fetal growth, the half-life of DHAS was more closely related to fetal than to placental weight.
D000757:Anencephaly / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D011254:Pregnancy in Diabetics / Q000378:metabolism
D003687:Dehydroepiandrosterone
Etude de la demi-vie du sulfate de déhydroépiandrostérone (DHAS) au cours de la grossesse