Selective blockage of the Na+ transport path by Bay g 2821.
A series of transport and electrophysiological experiments were carried out on rat salivery duct epithelium to study the mechanism of action of Bay g 2821 on electrolyte transport at the cellular level. On the basis of the reported data it is suggested that Bay g 2821 blocks Na+ entry into the cell at the luminal rather than at the intersitial membrane of the duct cell.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates; D001693:Biological Transport, Active / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D012469:Salivary Glands / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
D001639:Bicarbonates; D004232:Diuretics; D011720:Pyrazoles; D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium