[Ultrastructural study of dysgeneic ovaries of rats, resulting from Misulban administration during fetal life].
She-rats have been treated at the 15th day of gestation with Misulban. The she-rats born from the former ones present an ovarian dysgenesis due to a precocious destruction of the germinal cells by the radiomimetic. These dysgeneses are characterized by the presence of cordal epithelial structures and of stroma. Cells whose cytoplasmic infrastructure is characteristic of a steroidogenesis have been searched on ovaries taken of between 15 days and 6 months. In the absence of follicular organization, they appear only from puberty and are localized particularly, between the epithelial structures, in the conjonctive stroma.
D000014:Abnormalities, Drug-Induced; D000367:Age Factors; D000818:Animals; D002066:Busulfan; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis; D010053:Ovary / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D051381:Rats
D012739:Gonadal Steroid Hormones; D002066:Busulfan
Etude ultrastructurale d'ovaires dysgénésiques de rattes, obtenus par administration de misulban pendant la vie foetale