title: Heroin abuse and a gas chromatographic method for determining illicit heroin samples in Singapore.
abstract: The abuse of heroin (diacetylmorphine) in Singapore escalated sharply in 1975 and 1976, as indicated by the 35-fold increase in the number of heroin seizures and the 20-fold increase in the urine samples containing morphine since 1974. A rapid and simple GC method has been described to estimate diacetylmorphine (and caffeine). Monoacetylmorphine and acetylcodeine may be ascertained by an additional step involving acetylation. All gas chromatograms of a large number of samples analyzed consistently had the same pattern, indicating that they possibly had a common origin. This GC "fingerprint," together with the quantitative data, appears to be characteristic of the illicit Asian or Chinese type of heroin found in Singapore. The proportions of the four major ingredients in some twelve typical samples have been tabulated. Statistical data confirming the accuracy and reproducibility of the analytical method have also been presented.
mesh_terms: D002138:Calibration; D002849:Chromatography, Gas; D003932:Heroin / Q000032:analysis*; D006801:Humans; D012846:Singapore; D019966:Substance-Related Disorders
chemical_list: D003932:Heroin