Colcemid and related alkaloids inhibit lectin-mediated stimulation of RNA synthesis in human peripheral blood lymphocytes.
D003078:Colchicine / Q000494:pharmacology; D003703:Demecolcine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D037102:Lectins / Q000037:antagonists & inhibitors; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D014747:Vinblastine / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology*
D037102:Lectins; D014748:Vinca Alkaloids; D014747:Vinblastine; D012313:RNA; D003078:Colchicine; D003703:Demecolcine