[On the cytosic action of N-methyl-N-beta-chloraethyl-hydrazine and its benzaldehydhydrazone (author's transl)].
N-Methyl-N-beta-chloroethyl-hydrazine and its benzaldehydhydrazone are two new cytostatic methylhydrazines. Administered intraperitoneally, they are more effective in inhibiting the ascites tumor growth (Ehrlich's carcinoma in mice and Yoshida sarcoma in rats) than procarbazine in vitro as well as in vivo. The intraperitoneal administration of hydrazone shows a minor effect on the solid tumor. This may be explained by a different pharmacocinetical behaviour. Hydrazone is less toxic than procarbazine.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D006834:Hydrazines / Q000627:therapeutic use*; D006835:Hydrazones / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011344:Procarbazine / Q000627:therapeutic use; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy
D000970:Antineoplastic Agents; D006834:Hydrazines; D006835:Hydrazones; D011344:Procarbazine
Zur cytostatischen Wirkung von N-Methyl-N-beta-chlorthyl-hydrazin und seinem Benzaldehydhydrazon