title: [Participation of monoaminergic mechanisms and the striatum in the development of "petit mal" induced by corazole].
abstract: In gradual cumulation of subconvulsive doses of corasole in mice there are certain changes of behaviour and electrographical signs which are close to "petit mal": slow negative waves and peak-wave complexes on the EEG, myoclonic jerks. An increase of monoaminergic transmission of apomorphine, DOPA, or 5--hydroxyhyptophane weakens the preconvulsive effect of corasol, while its inhibition by aminasine, haloperidol and p-chlorphenylalanine on the contrary increases it. A low frequency electric stimulation of the striatum potentiates the expressiveness of corasole "petit mal", while its destruction limits it. A bilateral destruction of the striatum eliminates the action of apomorphine, DOPA and haloperidol but only slightly changes the effect of aminazine, 5-hydroxytryptophane and p-chlorphenylalanine.
mesh_terms: D006916:5-Hydroxytryptophan; D000818:Animals; D001058:Apomorphine; D001679:Biogenic Amines / Q000378:metabolism*; D002746:Chlorpromazine; D003342:Corpus Striatum / Q000378:metabolism / Q000503:physiopathology*; D004347:Drug Interactions; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000139:chemically induced* / Q000503:physiopathology; D010134:Fenclonine; D006220:Haloperidol; D007980:Levodopa; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats
chemical_list: D001679:Biogenic Amines; D007980:Levodopa; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D001058:Apomorphine; D010134:Fenclonine; D002746:Chlorpromazine; D010433:Pentylenetetrazole
vernacular_title: Uchasti monoaminergicheskikh mekhanizmov I striatuma v razvitii "malogo épilepticheskogo pripadka" vyzyvaemogo korazolom.