title: Alterations in the hippocampus of aged mice.
abstract: The hippocampus of C57B1/6 mice was examined histologically and electron microscopically. Male and female mice at 3 and 8 months of age and female mice at 16 months of age were studied. PAS positive foci, containing particles 1-2 mu in diameter, were observed in the hippocampal region of 8 and 16 month old mice. These particles were diastase sensitive. Electron microscopically, in similar mice, a vacuolating change was observed in the cytoplasm of perithelial cells (pericytes) in the same area.
mesh_terms: D000375:Aging; D000818:Animals; D003238:Connective Tissue / Q000648:ultrastructure; D003239:Connective Tissue Cells; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron
chemical_list: D006025:Glycosaminoglycans