Bone marrow transplantation between mixed lymphocyte culture-reactive individuals.
A 13-year-old boy with acute myelogenous leukemia resistant to conventional chemotherapy received a bone marrow transplant from his HL-A-identical, mixed lymphocyte culture-reactive sister. The recipient was prepared for transplantation with cyclophosphamide and total body irradiation. Despite cytogenetic evidence of engraftment, graft-versus-host disease was not observed. The patient died 38 days post-transplantation of Gram-negative bacteremia sepsis and recurrent leukemia of recipient origin.
D000293:Adolescent; D001803:Blood Transfusion; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use; D006098:Granulocytes / Q000528:radiation effects; D006648:Histocompatibility; D006801:Humans; D007165:Immunosuppression Therapy; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000276:immunology / Q000628:therapy; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011828:Radiation Chimera; D011830:Radiation Effects; D018805:Sepsis / Q000209:etiology; D014184:Transplantation, Homologous
D003520:Cyclophosphamide; D008727:Methotrexate