[Mechanism of the inhibitory effect of acetylcholine and its analogs on sarcolemma Na, K-ATPase].
Effect of acetylcholine on Na, K-ATPase from cardiac and skeletal rabbit muscles is studied. The inhibition of the enzyme by acetylcholine was shown to depend on the Na+/K+ ratio and Mg2+ concentration in the incubation medium. The sensitivity of Na, K-ATPase to acetylcholine and its analogues decreased as follows: acetylcholine, propionylcholine butyrylcholine, arecoline, carbacholine, choline. Muscle denervation resulted in 20-fold increase of the enzyme sensitivity to acetylcholine. Preparations of Na, K-ATPase from different muscles have the increasing sensitivity to acetylcholine in the following order: white, mixed, cardiac, denervated muscles.
D000109:Acetylcholine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012508:Sarcolemma / Q000201:enzymology*; D012964:Sodium / Q000378:metabolism
D001115:Arecoline; D002217:Carbachol; D012964:Sodium; D000251:Adenosine Triphosphatases; D000109:Acetylcholine; D011188:Potassium
O mekhanizme ingibiruiushchego deĭstviia atsetilkholina i ego analogov na Na, K-ATRazu sardolemmy