Editorial: Subunits of myosin. Relations to ATPase activity and mechanical function of muscle.
Under certain conditions the specific ATPase activity of myosin of a given muscle can be altered. The cause of this alteration can only lie in the myosin molecule itself. To produce an enzymatic activity of myosin, an interaction between their light and heavy chains is necessary. However, the specific activity appears to be determined mainly by light chains. Hence, one ought also to look for a basis of the changed activity in changes of the subunits of myosin. There are strong indications that the alterations in specific activity are accompanied by changes in the relative stoichiometry of the essential light chains of the respective myosin preparation. They differ in their pattern of subunits. The specific activity of a given kind of myosin seems to be determined by the combination of their light chains. Thus, a close correlation exists between these two properties of myosin (ATPase activity and structure of its molecule). There are sufficient indications, that these two properties of myosin correlate also with the mechanical capabiltiy of the corresponding muscle. Particularly the results of cross innervation studies demonstrate a close correlation between these three properties in skeletal muscle. The single subunits of myosin are produced and degraded independently and at heterogenous rates. The synthetis of these subunits is significantly accelerated in response to work overload. Thus, it is quite likely that the individual chains are non-coordinately synthesized, giving rise to variations in the relationship of different molecule types of myosin with different specific ATPase activity. Hence, the control mechanism to synthesize the individual subunits could also be the regulative mechanism to produce a myosin of the specific ATPase activity appropriate to the activity pattern of tissue.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002118:Calcium; D055598:Chemical Phenomena; D002621:Chemistry; D046911:Macromolecular Substances; D008970:Molecular Weight; D009119:Muscle Contraction; D009132:Muscles / Q000201:enzymology / Q000378:metabolism*; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009218:Myosins / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D011487:Protein Conformation; D051381:Rats
D046911:Macromolecular Substances; D000251:Adenosine Triphosphatases; D009218:Myosins; D002118:Calcium