Anticonvulsive effect of p-chlorophenylalanine in mice on a low magnesium diet.
We have reported previously that para-chlorophenylalanine prevented seizure manifestations in an inbred strain of mice genetically predisposed to audiogenic seizures. We now find that this protective effect is not limited to a particular inbred strain of susceptible animals but can be demonstrated in Swiss-Webster and CF No.1 strains which were not originally subject to audiogenic seizures but in which we have induced audiosusceptibility through maintenance on a low magnesium diet.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects; D010134:Fenclonine / Q000494:pharmacology*; D008275:Magnesium Deficiency / Q000503:physiopathology*; D008297:Male; D051379:Mice; D012640:Seizures / Q000503:physiopathology
D000927:Anticonvulsants; D010134:Fenclonine