title: Prevalence of thyroid disorder in Down syndrome.
abstract: Thyroid function has been studied in 121 patients between 13 and 48 years old with proven Down syndrome. Chemically, hypothyroidism was found in 17% and hyperthyroidism in 2.5% of the patients; 18% of patients had goiter. Thyroid antibodies were detected in 33% of subjects studied. The abnormal findings were almost equally distributed between the sexes above 20 years of age; however, females had significantly more thyroid disease than males in the younger age group.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006042:Goiter / Q000150:complications; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000276:immunology; D007037:Hypothyroidism / Q000150:complications* / Q000276:immunology; D008297:Male; D013960:Thyroid Function Tests