Esterase-7, a common constituent of numerous mouse tissues.
1. Electrophoretic and staining techniques for the relatively specific demonstration of esterase-7 in mouse tissues are described. Esterase-7 was found to be a common constituent of most mouse tissues. 2. The electrophoretic polymorphisms determined by three alleles a, b and c were studied in nine mouse strains. 3. The banding pattern of esterase-7 is being described and the isoelectric points of the allelic bands are being estimated. 4. Recombination studies on a further 129 animals confirmed that the Es-7 locus is tightly linked to Es-2 and Es-11. 5. Esterase-7 precipitates with antiesterase-2 from the rabbit. 6. It differs from esterase-2 by its individual substrate preference and by its susceptibility to inhibition by acylating agents.
D000483:Alleles; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D004950:Esterases / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D005779:Immunodiffusion; D007123:Immunoelectrophoresis, Two-Dimensional; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D008970:Molecular Weight; D010641:Phenotype; D014018:Tissue Distribution
D004950:Esterases