[Lipids in serum and cerebrospinal fluid in acute cerebrovascular disorders].
The cholesterol and lipoid phosphorus levels in the serum and liquor' cerebrospinalis were studied in 40 patients suffering from ischaemic cerebral lesions. A chromatographic determination was also performed for eight sub-fractions of polar and neutral fats (lysolecithin, sphingomyelin, lecithin, phosphatidyl-ethanolamine, non-esterified fatty acids, cholesterol, triglyceride and cholesterol ester). Furthermore, five sub-fractions of cholesterol esters were prepared according to the degree of unsaturation in the individual fatty acids. The results were compared with a group of 25 control persons. No significant changes in the lipide sub-fractions were found in the serum. Total cholesterol was lower for cerebral haemorrhages, lipoid phosphorus was higher. In the liquor, no increase was found in total lipides but only a shift in some lipide fractions, the most pronounced being a lowering in triglyceride and an increase in free cholesterol and sphingomyelin. It would seem that a determination of lipides in the serum and liquor is not decisive for the diagnosis of acute vascular cerebral haemorrhages. These questions require thorough research and experimentation.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D002545:Brain Ischemia / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism
D010743:Phospholipids; D002784:Cholesterol
Lipide im Serum und im Liquor bei akuten zerebrovaskulären Störungen.