Influence of long-term treatment with dipyridamole on the aorta-stenosed rabbit heart: morphometric and functional investigations.
The well-known effects of dipyridamole on the increase of the coronary vessel system and on cardiac metabolism suggest that dipyridamole may have a favourable influence on the chronic pressure loaded heart. In the model of the aorta-stenosed growing rabbit the cardiomegaly was diminished after a 3-month treatment using high doses of dipyridamole. Histometrically a marked decrease of the enlargement of the cross-sectional area of muscle fibres was found. It is assumed that dipyridamole retards myocardial hypertrophy and stimulates hyperplasia. Simultaneously the impairment of distinct parameters of cardiac contractility in the aorta-stenosed heart was prevented in growing rabbits by long-term dipyridamole treatment.
D000818:Animals; D001024:Aortic Valve Stenosis / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy*; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits
D004176:Dipyridamole