Analytical approach to mathematical modelling of the isometric contraction of the hypertrophied myocardium.
It is attempted on the basis of the Hill two-element model to simulate mathematically the rising phase of the isometric mechanogram in the pressure-hypertrophied rat myocardium (Goldblatt II). The evaluation is based on the experimentally determined force-velocity relation as well as on the characteristic of the series-elastic stiffness. The changes in the isometric mechanogram of the hypertrophied heart muscle observed in the experiment can be mathematically predicted solely by means of the alterations in the force-velocity relationships induced by the hypertrophy, whereby the characteristic of the series-elastic stiffness is considered to be unchanged.
D006332:Cardiomegaly / Q000503:physiopathology*; D004548:Elasticity; D008433:Mathematics; D008954:Models, Biological; D009200:Myocardial Contraction; D013997:Time Factors