[Effect of corticosteroids, vitamins and their combination with thiophosphamide on the indicators of carbohydrate and electrolyte metabolism of animals with experimental tumors].
On a model of transplantable albeolar-mucous RS cancer it is shown that hydrocortisone, desoxycorticosteonre-acetate (DOCA), cyanocobalamine used in combination with folic and nicotinic acids does not lower the cytostatic activity of thiophosphamide and in a number cases even potentiates its action. A relation between changes occurring under the influence of the chemical agents on the energy exchange (a fall of the lactate level) and the linked with it transfer of ions (reduced concentration of magnesium, calcium and a rise in the level of sodium) through the membranes of cancer cells was revealed. Against the background of chemotherapy gycolytic processes in the malignant cells. Evidence was brought to bear that under the influence of thiophosphamide the response of the neoplastic tissue to DOCA becomes perverted (the concentration of potassium goes up and the level of sodium delcines).
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D004407:Dysgerminoma / Q000378:metabolism*; D005492:Folic Acid / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D009539:Nicotinic Acids / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013852:Thiotepa / Q000494:pharmacology*; D014805:Vitamin B 12 / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
D004338:Drug Combinations; D007773:Lactates; D009539:Nicotinic Acids; D014815:Vitamins; D009536:Niacinamide; D003900:Desoxycorticosterone; D013852:Thiotepa; D005492:Folic Acid; D012964:Sodium; D008274:Magnesium; D014805:Vitamin B 12; D011188:Potassium; D002118:Calcium; D006854:Hydrocortisone
Vliianie kortikosteroidov, vitaminov i ikh sochetaniĭ s tiofosfamidom na pokazateli uglevodnogo i elektrolitnogo obmena u zhivotnykh s opukhol'iu