title: Uncouplers and the molecular mechanism of uncoupling in mitochondria.
abstract: Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The molecular mechanism of uncoupling sheds strong light on the mechanism of coupling.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001693:Biological Transport, Active; D000001:Calcimycin / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D002417:Cattle; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology; D004579:Electron Transport; D007700:Kinetics; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium; D009550:Nigericin / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology*; D012413:Rubidium / Q000378:metabolism; D014475:Uncoupling Agents; D014634:Valinomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002352:Carrier Proteins; D014475:Uncoupling Agents; D014634:Valinomycin; D000001:Calcimycin; D004492:Edetic Acid; D000251:Adenosine Triphosphatases; D012413:Rubidium; D009550:Nigericin; D011188:Potassium