title: [HL-A system antigen distribution in malignant neoplasm patients].
abstract: The distribution of transplantation HL-A antigens in 124 patients (cancer of the stomach, mammary glands, the large intestine, the lung, skeletal sarcoma) was studied in microlymphocyte toxic reaction. A comparison with the results of the analogous examination of healthy persons dwelling in Leningrad indicated certain differences in the frequency of encountering some antigens, and the absence of HLA-B18 antigen among patients. Most frequently (in 62%) an "incomplete set" of antigens was found in a group of patients, antigens typical for the whole locus (more frequently "B") being absent in 7.3%. In 6.4% "extra" (live or more) HL-A antigens were noted. The use of adaptive immunotherapy would significantly change antigenic spectrum of lymphocytes in patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D012426:Russia; D009626:Terminology as Topic; D014505:Urban Population
chemical_list: D006680:HLA Antigens
vernacular_title: Raspredelenie antigenov sistemy HL-A u bol'nykh zlokachestvennykh novoobrazovaniiami.