Inhibition by 2,4-dinitrophenol of 9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch.
After topical treatment of cheek pouches of 10 hamsters with 9,10-dimethyl-1,2-benzanthracene and 2,4-dinitrophenol for 10 weeks no carcinomas developed in any of the animals. After treatment of 10 animals with the carcinogen only, there were 49 carcinomas in the 8 survivors. Inhibition of chemical carcinogenesis by dinitrophenol was tentatively attributed to suppression of ATP synthesis and to activation of ATPase by dinitrophenol.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D006224:Cricetinae; D004140:Dinitrophenols / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D001551:Benz(a)Anthracenes; D004140:Dinitrophenols; D015127:9,10-Dimethyl-1,2-benzanthracene; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases