Formation of lipoperoxide in isolated sciatic nerve by chinoform-ferric chelate.
Effects of chinoform and chinoform-ferric chelate on formation of lipoperoxide in isolated sciatic nerve were investigated. Free chinoform did not increase the lipoperoxide level, while chinoform-ferric chelate significantly increased it. Assuming that the lipoperoxide formed denatures the associated protein in the nerve, the effect of chinoform-ferric chelate could explain, at least partly, the demyelination of nerve tissues caused by massive doses of chinoform.
D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D007464:Clioquinol / Q000494:pharmacology*; D005290:Ferric Compounds / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D010545:Peroxides / Q000378:metabolism; D011817:Rabbits; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism
D002614:Chelating Agents; D005290:Ferric Compounds; D010545:Peroxides; D007464:Clioquinol; D007501:Iron