The in vivo inhibition of tumor growth by ruthenium red: its relationship with the metabolism of calcium in the tumor.
Ruthenium red shows antitumor activity on experimental tumors. This growth inhibition seems to be related with the impairment of Ca-2+ transport both at the mitochondrial and at the cell membrane level. A sex influence modifying this inhibition and the systemic effects has been observed.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D007424:Intracellular Fluid / Q000378:metabolism; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008274:Magnesium / Q000378:metabolism; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D012428:Ruthenium / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000188:drug therapy
D010758:Phosphorus; D012428:Ruthenium; D008274:Magnesium; D002118:Calcium