title: Aerosol Sch 1000. An anticholinergic bronchodilator.
abstract: Atropine is known to be an effective bonrchodilator. We studied the effectiveness of aerosol Sch 1000, a derivative of atropine, in relieving bronchoconstriction in asthma. A single dose of drug was effective within 5 min, and the effect had a duration of 4 hours. No side effects were noted. The major effect of the drug appeared to be in large airways.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001286:Atropine Derivatives; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage / Q000627:therapeutic use*; D007545:Isoproterenol / Q000008:administration & dosage / Q000627:therapeutic use; D008450:Maximal Midexpiratory Flow Rate; D010919:Placebos; D014797:Vital Capacity
chemical_list: D000336:Aerosols; D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D010919:Placebos; D009241:Ipratropium; D007545:Isoproterenol