Drug induced interstitial nephritis, hepatitis and exfoliative dermatitis.
Acute interstitial nephritis associated with hepatitis, exfoliative dermatitis, fever and eosinophilia is uncommon. The syndrome has been described previously in association with phenindione administration, leptospirosis and heavy metal poisoning. Four cases are described, two of which were due to phenindione sensitivity. The other two patients had been exposed to a number of toxins including allopurinol, frusemide, chlorothiazide and methyldopa so that the exact aetiological agent is unclear. Interstitial nephritis should be considered as a cause of acute renal failure in patients with other features of drug hypersensitivity.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000493:Allopurinol / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D010630:Phenindione / Q000009:adverse effects*
D010630:Phenindione; D000493:Allopurinol