[Comparative study on lymphocyte stimulation by PHA and bacterial endotoxins, particularly in malignant tumor and allergy patients].
In a group of 37 tumor patients with predominantly advanced disease, LPS stimulation (LPS of Sh. sonnei and Sh. flexneri) resulted in a significant increase of the transformation rates caused, most probably, by the high proportion of B cells. On the other hand, allergics (drug allergies) did not differ from controls. It seems possible that B cell stimulation by bacterial endotoxins can be used for the assessment of the reactivity of the organism.
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D004342:Drug Hypersensitivity / Q000276:immunology*; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D012763:Shigella flexneri; D012764:Shigella sonnei
D004731:Endotoxins; D037102:Lectins; D008070:Lipopolysaccharides
Vergleichende Untersuchungen zur Lymphozytenstimulation durch PHA und bakterielle Endotoxine, insbesondere bei Patienten mit bösartigen Geschwülsten und Allergie