Increased somatostatin content of islets from streptozotocin-diabetic rats.
Pancreatic islets were isolated from control and streptozotocin-diabetic rats. Somatostatin content as determined by radioimmunoassay was strikingly increased in the diabetic group. Immunoreactive insulin content was markedly reduced and glucagon was moderately increased. The mechanisms responsible for the somatostatin changes are unknown.
D000818:Animals; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013311:Streptozocin
D013004:Somatostatin; D013311:Streptozocin