Antigen-induced cyclophosphamide-resistant suppressor T cells inhibit the in vitro generation of cytotoxic cells from one-way mixed leukocyte reactions.
Mice sensitized against a tumor allograft and given cyclophosmamide 6 days later failed to generate an immune response to the allograft. Spleen cells derived from these mice suppressed the generation of cytotoxic T cell response by normal spleen cells in mixed leukocyte cultures. The suppressor cells were not specific, thymus dependent, and resistant to 2000 R.
D000818:Animals; D000961:Antilymphocyte Serum; D003520:Cyclophosphamide / Q000494:pharmacology*; D004351:Drug Resistance; D006649:Histocompatibility Antigens; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens; D003520:Cyclophosphamide