Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor.
The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G-25) responsible for suppression of antigen-induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen-induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10(-2)M) and suppressive over a relatively broad range (10(-5) to 10(-2)M. The suppression appeared to be related to the magnitude of antigen- or mitogen-induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.
D000941:Antigens; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007165:Immunosuppression Therapy; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens; D009536:Niacinamide / Q000494:pharmacology*; D014165:Transfer Factor; D014373:Tuberculin / Q000276:immunology
D000941:Antigens; D037102:Lectins; D008934:Mitogens; D014165:Transfer Factor; D014373:Tuberculin; D009536:Niacinamide