title: Myeloid regeneration after whole body irradiation, autologous bone marrow transplantation, and treatment with an anabolic steroid.
abstract: Stumptail monkeys (Macaca speciosa) received lethal whole body radiation. Autologous bone marrow injection resulted in survival of the majority of the animals. Treatment with Deca-Durabolin, an anabolic steroid, caused more rapid recovery of colony-forming cell numbers in the bone marrow than in control animals. Both the Deca-Durabolin-treated and control groups were given autologous bone marrow transplantation. Anabolic steroid effect on transplanted bone marrow colonyforming cells may explain the increased rate of leukopoietic regeneration in anabolic steroid-treated animals as compared to controls.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002999:Clone Cells; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes; D007959:Lymphocyte Culture Test, Mixed; D008251:Macaca; D008297:Male; D009277:Nandrolone / Q000494:pharmacology*; D011829:Radiation Dosage; D011830:Radiation Effects; D012038:Regeneration; D014182:Transplantation, Autologous
chemical_list: D009277:Nandrolone