[Adult-type Gaucher's disease: an histochemical study of one case (author's transl)].
Spleen of adult-type Gaucher's disease has been investigated by histochemical technics. As usually, an overload of cerebroside (revealed by the PAS reaction for glycolipids) with beta-glucosidase deficiency has been demonstrated. But many particularities must be emphasized in this case: increase of acid MPS, high activities of pentose pathway--and glycolysis enzymes in the overload cells.
D000328:Adult; D002554:Cerebrosides / Q000032:analysis; D005776:Gaucher Disease / Q000378:metabolism*; D006019:Glycolysis; D006025:Glycosaminoglycans / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D010088:Oxidoreductases / Q000032:analysis; D010428:Pentosephosphates / Q000378:metabolism; D013154:Spleen / Q000032:analysis
D002554:Cerebrosides; D006025:Glycosaminoglycans; D010428:Pentosephosphates; D010088:Oxidoreductases
Etude histoenzymologique d'un cas adulte de maladie de Gaucher