[Influence of thymectomy on the lymphoid regeneration of hematopoietic bone marrow after sublethal irradiation].
In C57BL mice, bone marrow lymphoid regeneration after a sublethal irradiation is modified by a graft of normal marrow cells. This effect is suppressed in thymectomized mice since a lymphoid peak is observed after a 350 R irradiation; its composition is heterogeneous: small lymphocytes, lymphoblasts and peculier cells named "X cells". The same phenomenon is observed in mice where all the thymocytes and thymus derived and peripheral lymphocytes are destroyed. These results exclude that bone marrow lymphoid regeneration after irradiation is due to a migration of lymphoid cells of thymic origin to the marrow. They could be explained by the effect of a humoral thymic factor on marrow lymphopoiesis.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005260:Female; D008221:Lymphoid Tissue / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011833:Radiation Injuries, Experimental; D012038:Regeneration; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*; D014184:Transplantation, Homologous
Influence de la thymectomie sur la régénération lymphoïde de la moelle hématopoïétique après une irradiation sublétale