[Effectiveness of syrepar in experimental liver dystrophy in albino rats].
In experiments with rats it was found that syrepar is an effective agent in acute dystrophy provoked by carbon tetrachloride. Its daily administration in an amount of 0.1 ml per 100 g of weight subcutaneously improves the general condition of the animals, prevents their destruction, accelerates restoration of the structure and function of the liver. Much earlier and more fully the cholepoietic function of the liver, the ultrastructural organization of hepatocytes, as well as the activity of hepatic enzymes, along with the glycogen content and of cytoplasmatic RNA were re-established.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000096:biosynthesis; D001663:Bilirubin / Q000378:metabolism; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D002784:Cholesterol / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004341:Drug Evaluation; D005500:Follow-Up Studies; D008099:Liver / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D008107:Liver Diseases / Q000188:drug therapy*; D008110:Liver Extracts / Q000627:therapeutic use*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D001647:Bile Acids and Salts; D008110:Liver Extracts; C014814:sirepar; D004247:DNA; D002784:Cholesterol; D002251:Carbon Tetrachloride; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D001663:Bilirubin
Effektivnost' sirepara pri eksperimental'noĭ distrofii pecheni u belykh krys