[Nitrosamin induced neoplasms of the colon and rectum. Investigations on the morphogenesis in rats (author's transl)].
The morphogenesis of neoplasms (carcinomas and pracecancerous polypoid lesions) induced by N-methyl-N-nitroso-N'-nitroguanidine (MNNG) was studied on 154 male Wistar rats (including controls), from which a group received a colostomy. Operated and non-operated rats were treated by intrarectal instillations of 2 mg per kg body weight MNNG twice a week during a period of 210 days.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D003125:Colostomy; D007417:Intestinal Polyps / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009374:Neoplasms, Experimental; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008769:Methylnitronitrosoguanidine
Tierexperimentelle Untersuchungen zur Morphogenese Nitrosamin-induzierter colo-rectaler Tumoren