[Effects of sodium n-dipropylacetate on the GABA level in various areas of the mouse brain].
Regional brain GABA distribution studies show that after administration of sodium n dipropylacetate, a competitive inhibitor of GABA transaminase, the concentration of GABA increases in some regions i.e. Olfactory Bulbs, Hypothalamus, Cortex, Cerebellum. The GABA level remains unchanged in Caudate Nucleus, Pons Medulla, Hippocampus in our experimental conditions. These variations do not correlate with the initial GABA level.
D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008526:Medulla Oblongata / Q000378:metabolism; D051379:Mice; D009830:Olfactory Bulb / Q000378:metabolism; D011149:Pons / Q000378:metabolism; D014631:Valerates / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000613:Aminobutyrates; D014631:Valerates; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid
Effets du n-dipropylacétate de sodium sur le taux de GABA de certaines zones du cerveau de la souris