title: [Tryptophan-load in progressive scleroderma (author's transl)].
abstract: This presentation describes effects of oral tryptophan loading (5.0 g DL) on tryptophan metabolism in healthy subjects (n = 10) and persons with progressive scleroderma. N1-methylnicotinamide (N1MN), 3-hydroxyanthranilic acid (3 HAA), kynurine (KN), tryptamin (TA), xantheurenic acid (XA) were determinated. Alterations of tryptophan metabolism were evaluated by 24 h urinary excretions of the following metabolites: 5-hydroxy indolacetic acid (5 HAA) and indole-3-acetic acid (IAA). The pathological pathways were discussed, especially the way and influence of serotonine.
mesh_terms: D015095:3-Hydroxyanthranilic Acid / Q000652:urine; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007210:Indoleacetic Acids / Q000652:urine; D007737:Kynurenine / Q000652:urine; D008297:Male; D009536:Niacinamide / Q000652:urine; D012595:Scleroderma, Systemic / Q000378:metabolism*; D012701:Serotonin / Q000032:analysis; D012867:Skin / Q000032:analysis; D014363:Tryptamines / Q000652:urine; D014364:Tryptophan / Q000008:administration & dosage / Q000378:metabolism*; D014977:Xanthurenates / Q000652:urine
chemical_list: D007210:Indoleacetic Acids; D014363:Tryptamines; D014977:Xanthurenates; D015095:3-Hydroxyanthranilic Acid; D009536:Niacinamide; D012701:Serotonin; D007737:Kynurenine; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan
vernacular_title: Der Tryptophan-Stoffwechsel bei der progressiven Sklerodermie