[Early teratogen effect of neutral desoxyribonuclase on young chick embryo].
Neutral DNA-ase acts as a general teratogen when given to young chicken blastoderms. The rate of the differents abnormalities varies according to the dose given and the embryos' stage. The frequency of the different defects reaches a maximum value with increasing doses it falls generally down with more important doses. DMSO added to the enzyme solution changes the susceptibility of the embryos.
D000014:Abnormalities, Drug-Induced; D000367:Age Factors; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002642:Chick Embryo / Q000187:drug effects*; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D009024:Morphogenesis / Q000187:drug effects
D003851:Deoxyribonucleases; D004121:Dimethyl Sulfoxide
Action tératogène précoce de la désoxyribonucléase neutre chez le jeune embryon de poulet