Psoralen photosensitization of L 1210 leukaemia cells: an approach to a new combined therapy.
Psoralen photosensitization of L 1210 cells has a strong effect on DNA and RNA syntheses and this result appears connected with the psoralen photobinding to DNA. Protein synthesis is less sensitive and its inhibition seems due to a different photochemical interaction, very likely to the psoralen photobinding to RNA. A combined therapy using cyclophosphamide and L 1210 cells psoralen-photoinactivated was performed after the leukaemia transplant, showing a significant decrease in mortality, even in comparison with the simple treatment with the alkilating drug.
D000818:Animals; D003374:Coumarins / Q000627:therapeutic use*; D004247:DNA / Q000096:biosynthesis; D005363:Ficusin / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008811:Mice, Inbred DBA; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D003374:Coumarins; D012313:RNA; D004247:DNA; D005363:Ficusin