Antagonism of d-lysergic acid diethylamide and mescaline by 1-methyl-1, 2, 5, 6-tetrahydropyridine-N, N-diethyl-carboxamide (THPC).
Contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and d-lysergic acid diethylamide (LSD) were antagonized by 1-methyl-1, 2, 5, 6-tetrahydropyridine-N, N-diethyl-carboxamide (THPC) 5 X 10(-4)M. THPC did not block contractile responses to angiotensin. The data are interpreted to support our previous suggestions that certain chemical entities representing portions of the LSD molecule may be effectively studied as antagonists to the hallucinogens. The present data indicate that THPC is a weak 5-hydroxytryptamine receptor antagonist.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008238:Lysergic Acid Diethylamide / Q000037:antagonists & inhibitors*; D008635:Mescaline / Q000037:antagonists & inhibitors*; D009119:Muscle Contraction / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D012702:Serotonin Antagonists; D012756:Sheep; D014469:Umbilical Arteries / Q000187:drug effects
D012702:Serotonin Antagonists; D000804:Angiotensin II; D009536:Niacinamide; D008238:Lysergic Acid Diethylamide; D008635:Mescaline