title: [On the cytostatic mechanism of action of N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone (author's transl)].
abstract: N-Methyl-N-beta-chloroethyl-hydrazine and its bezaldehydhydrazone inhibit the synthesis of DNA and RNA in ascites cells in vitro faster and stronger than N,N-Dimethylhydrazine and procarbazina does. The benzaldehydhydrzone essentially inhibits influx and phosphorylation of nucleosides whereas N-Methyl-N-beta-chloroethylhydrazine acts directly on DNA synthesis.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004127:Dimethylhydrazines / Q000494:pharmacology; D006834:Hydrazines / Q000494:pharmacology*; D006835:Hydrazones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009711:Nucleotides / Q000378:metabolism; D011344:Procarbazine / Q000494:pharmacology; D012334:RNA, Neoplasm / Q000096:biosynthesis
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004127:Dimethylhydrazines; D006834:Hydrazines; D006835:Hydrazones; D009363:Neoplasm Proteins; D009711:Nucleotides; D012334:RNA, Neoplasm; D011344:Procarbazine
vernacular_title: Zum cytostatischen Wirkmechanismus von N-Methyl-N-beta-chloräthylhydrazin und seinem Benzaldehydhydrazon