Spontaneous recovery from streptozotocin-induced diabetes in rats pretreated with pertussis vaccine or hydrocortisone.
Following the intravenous injection of streptozotocin into rats, postprandial hyperglycaemia was sustained from 24 hours over a subsequent period of some weeks and the rats were glucose intolerant. When streptozotocin was similarly injected into pertussis-sensitized or hydrocortisone treated rats, the postprandial hyperglycaemia observed at 24 hours did not persist, but showed a progressive decline until near normoglycaemia was obtained a week later. These animals manifested normal glucose tolerance one week after streptozotocin. Thus, a spontaneous recovery from streptozotocin-induced diabetes occurred under these conditions. This spontaneous recovery from diabetes was associated with hyperinsulinaemia in the fed state.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000517:prevention & control*; D005951:Glucose Tolerance Test; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D010567:Pertussis Vaccine / Q000494:pharmacology*; D051381:Rats; D013311:Streptozocin
D001786:Blood Glucose; D007328:Insulin; D010567:Pertussis Vaccine; D013311:Streptozocin; D006854:Hydrocortisone