title: The metabolic clearance rate of dehydroisoandrosterone sulfate. III. The effect of thiazide diuretics in normal and future pre-eclamptic pregnancies.
abstract: The present study reports that the metabolic clearance rate of dehydroisoandrosterone sulfate (MCRDS) is decreased by thiazide diuretics during normal and future pre-eclamptic pregnancies. This observation supports the thesis that diuretics represent a potential hazard to the fetus by decreasing placental perfusion.
mesh_terms: D001581:Benzothiadiazines; D001835:Body Weight; D003687:Dehydroepiandrosterone / Q000378:metabolism* / Q000652:urine; D004232:Diuretics; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D008423:Maternal Age; D008431:Maternal-Fetal Exchange; D008657:Metabolic Clearance Rate; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D003687:Dehydroepiandrosterone