[Phentolamine and dibenamine action on the carotid reflexes induced by lobeline].
On the carotid reflexogenic zone lobeline provoques : 1) a increase of amplitude and rate of respiratory  movements with bradycardia and hypotension ; 2) a secondary decrease of amplitude and rate of breathing with tachycardia. Acting on the reflexogenic zone, phentolamine and dibenamine provoque a transitory weakening or disappearance of these reflexes. These effects are induced by a local action, because they are not observed by intravenous injection of the drugs and the lobeline reflexes starting from the carotid sinus of the other side are not affected.
D000818:Animals; D002628:Chemoreceptor Cells / Q000187:drug effects; D003983:Dibenzylchlorethamine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008120:Lobeline / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects
D003983:Dibenzylchlorethamine; D008120:Lobeline; D010646:Phentolamine
Action de la phentolamine et de la dibénamine sur les réflexes carotidiens déclenchés par la lobéline.