[Dose-effects of the contrast medium Iotroxinate on biliary excretion of contrast media during infusion cholegraphy (author's transl)].
In the anaesthetized pig we studied the influence of the dosage of the contrast medium Iotroxinate on the following parameters of bile secretion: bile flow, bile salt excretion, concentration, and excretion of Iotroxinate. The results demonstrate that high doses of Iotroxinate inhibit the bile salt independent fraction of bile flow in a dose-dependent manner, by analogy to organic anions like Rose Bengal, Indocyaningreen, Ioglycamite. The biliary concentration of Iotroxinate however increases slightly. That means, that high doses of Iotroxinate do not impair the quality of opacification of bile ducts in x-ray examinations, as the contrast medium concentration represents the decisive parameter for a valid cholegraphy.
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D002765:Cholecystography; D003287:Contrast Media / Q000008:administration & dosage* / Q000378:metabolism; D007263:Infusions, Parenteral; D007463:Iodobenzoates / Q000008:administration & dosage*; D007471:Ioglycamic Acid / Q000008:administration & dosage* / Q000378:metabolism; D013552:Swine
D003287:Contrast Media; D007463:Iodobenzoates; D007471:Ioglycamic Acid
Zum Einfluss der Dosierung des Kontrastmittels Iotroxinat auf die biliäre Kontrastmittel-ausscheidung während der Infusionscholegraphie.