Prune-belly syndrome associated with Potter (renal nonfunction) syndrome.
Three fatal cases of prune-belly syndrome were associated with nonrenal features of Potter syndrome. The abdominal muscle hypoplasia is thought to be a result of large kidneys compression the developing abdominal musculature during a critical phase of fetal development. Thus, Potter syndrome and prune-belly syndrome may coexist when nonfunctioning large kidneys result in oligohydramnios. A teratogenic role of cytomegalovirus inclusion disease and other viruses is possible in the pathogenesis of these syndromes.
D000009:Abdominal Muscles / Q000002:abnormalities*; D000015:Abnormalities, Multiple / Q000196:embryology / Q000209:etiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D005145:Face / Q000002:abnormalities*; D005260:Female; D005315:Fetal Diseases / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000473:pathology; D008297:Male; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D013577:Syndrome; D013737:Testis / Q000002:abnormalities*; D014564:Urogenital Abnormalities; D014777:Virus Diseases / Q000150:complications