[Incidence and manifestations of the heterozygosity of the gene causing diabetes].
A model of intermediate inheritance of diabetes mellitus is given, according to which juvenile diabetes developes in persons homozygous for the mutant gene, and a part of heterozygous carrier of the mutant gene has late diabetes mellitus. A large group of diabetes cases (about 50%), which are not due to direct diabetes heredity, is taken into account. Calculations are carried out on the basis of Hardy-Weinberg law from the patient questionaire data. The frequency of juvenile diabetes (developing within first thirty years) is 0,028% in the Leningrad population, the frequency of heterozygous diabetes gene carrier being 3,28%. Penetrancy of the diabetes gene in heterozygous state, as estimated from registrable (clinically expressed) forms of the disease, is 8,4%. The risk of juvenile diabetes in children, if one of the parents has juvenile diabetes, is 1,65% (3,3%-1/2), the frequency of heterozygous carriers in the population being 3,3%. The analysis of questionaire data of diabetes patients produced results, which were close to expected and indirectly confirmed the accurancy of the model proposed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D012383:Romania; D012426:Russia
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