title: One-way nonstimulation of mixed leukocyte culture in dog families.
abstract: Fifteen dog families were studied in mixed leukocyte culture.  In eight families of seven different breeds, one-way nonstimulation in mixed leukocyte culture was observed.  This could be explained by lymphocyte-defined (LD) homozygosity in most instances.  In one family, an inclusion phenomenon was postulated, and in another, a deletion.  LD homozygotes can serve as reference for LD typing and can also help elucidate the relative role of the LD locus for transplantation of organs.
mesh_terms: D000818:Animals; D001947:Breeding; D003601:Cytotoxicity Tests, Immunologic; D004285:Dogs; D005260:Female; D006650:Histocompatibility Testing; D037102:Lectins; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male
chemical_list: D037102:Lectins