Studies on the metabolism of beta-hydroxy- aspartic acid.
The content of beta-hydroxyaspartic acid was measured in the urine of man and several species of animals. The configuration of urinary beta-hydroxyaspartic acid was deduced to be L-erythro in form by chromatographic comparisons with authentic samples. An increased excretion of urinary beta-hydroxyaspartic acid was observed in cats when serine or thiamine was administered with glycine. Glycine-1-14C administered to rats was incorporated into the urinary beta-hydroxyaspartic acid. The formation of beta-hydroxyaspartic acid in pig-liver homogenate increased in the presence of glutamate and thiamine pyrophosphate. These results were discussed in relation to the author's working hypothesis on the biosynthesis of beta-hydroxyaspartic acid.
D000818:Animals; D001224:Aspartic Acid / Q000096:biosynthesis / Q000378:metabolism* / Q000652:urine; D004285:Dogs; D005971:Glutamates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012694:Serine / Q000378:metabolism; D013045:Species Specificity; D013552:Swine; D013831:Thiamine / Q000378:metabolism
D005971:Glutamates; D001224:Aspartic Acid; D012694:Serine; D005998:Glycine; D013831:Thiamine