Biological properties of rat serum hydrolases splitting N-acetyl-L-tyrosine ethyl ester.
An increase in the level of activity splitting N-acetyl-L-tyrosine ethyl ester (ATEE) was found in the plasma of rats with experimentally induced rheumatoid inflammation. The level of this activity rose paralled with development of the inflammation. Homogenate of inflamed rat paws was found to contain a raised content of the high molecular weight fraction. Which was found to contain a raised content of the fraction I (splitting ATEE) causes an increase in vascular permeability and releases active kinins from plasma kininogens. These properties were also found, on a smaller scale, in serum fraction II. The results show no parallel between ATEE-splitting activity and the magnitude of the biological response.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D006168:Guinea Pigs; D006867:Hydrolases / Q000097:blood*; D006868:Hydrolysis; D007616:Kaolin; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000097:blood; D008970:Molecular Weight; D051381:Rats; D012216:Rheumatic Diseases / Q000139:chemically induced / Q000201:enzymology; D014443:Tyrosine / Q000031:analogs & derivatives*
D007704:Kininogens; D007705:Kinins; D007616:Kaolin; D014443:Tyrosine; D006867:Hydrolases