[Pharmacological analysis of the pendular movements appearing during calcium blocking of peristalsis in the isolated guinea pig ileum].
Calcium chloride acting from the serosal surface blocked the peristaltic reflex and at the same time, after about 30 minutes, evoked pendulum type of activity in the longitudinal muscle of the guinea-pig isolated ileum, subjected to constant intraluminal pressure. Hexamethonium, tetraethylammonium, morphine, methadone and atropine blocked, while, neostigmine potentiated the pendulum movements evoked by calcium chloride. In the Magnus preparation of the guinea-pig isolated ileum calcium chloride also caused pendulum type of activity. From these experiments it is concluded that calcium chloride evoked pendular movements by stimulating the postganglionic cholinergic nerves in the longitudinal muscle of the guinea-pig isolated ileum.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007082:Ileum; D008691:Methadone / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009388:Neostigmine / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D006584:Hexamethonium Compounds; D013757:Tetraethylammonium Compounds; D009388:Neostigmine; D009020:Morphine; D001285:Atropine; D002118:Calcium; D008691:Methadone
Analyse pharmacologique des mouvements de type pendulaire apparaissant pendant le blocage, par le calcium, du péristaltisme de l'iléon isolé de Cobaye.