Treatment with glucagon-binding antibodies alters the intestinal response to starvation in the rat.
Everted intestinal rings from partially starved rats accumulate the nonmetabolized amino acid 1-amino-cyclopentane-5-carboxylic acid (ACPC) at an enhanced rate. Plasma glucagon concentrations were found to be markedly elevated in these partially starved rats as well as in rats with experimentally induced diabetes, a condition previously shown to be associated with augmented intestinal uptake of amino acid. Treatment of partially starved rats with repeated injections of glucagon-binding antiserum prevented increased ACPC uptake of intestinal rings. Chronically elevated plasma glucagon levels may participate in the mechanism of the functional changes in the intestine in partial starvation.
D000818:Animals; D000906:Antibodies; D001692:Biological Transport; D003920:Diabetes Mellitus / Q000139:chemically induced; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005934:Glucagon / Q000276:immunology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D013217:Starvation / Q000378:metabolism*; D013311:Streptozocin
D000906:Antibodies; D013311:Streptozocin; D005934:Glucagon