[Characteristics of the toxicological action of carbophos against a background of polychloropinene].
Tests conducted with rabbits brought evidence that carbophos priming per os (1/25DL50 for 45 days) reduces the oxyhemoglobin dissociation rate, increases the ascorbic acid concentration in the blood and brain, of copper in the blood, brain and kidneys. Priming with a mixture of carbophos and polychloropinene (in a summary dose of 1/25DL50) was attended by a decline in the oxyhemoglobin, rising a concentration of ascorbic acid in the blood, of manganese in the kidneys and iron in the muscles. Changes in the oxyhemoglobin dissociation rate and ascorbic acid concentration were more significant after introduction of a mixture of pesticides.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001769:Blood / Q000187:drug effects; D003300:Copper / Q000378:metabolism; D004338:Drug Combinations; D007306:Insecticides / Q000633:toxicity*; D007501:Iron / Q000378:metabolism; D008294:Malathion / Q000633:toxicity*; D008345:Manganese / Q000378:metabolism; D010108:Oxyhemoglobins / Q000032:analysis; D011817:Rabbits; D013729:Terpenes / Q000633:toxicity*; D013831:Thiamine / Q000378:metabolism; D013997:Time Factors
D004338:Drug Combinations; D007306:Insecticides; D010108:Oxyhemoglobins; D013729:Terpenes; D008345:Manganese; D003300:Copper; D007501:Iron; D001205:Ascorbic Acid; D008294:Malathion; D013831:Thiamine
Osobennosti toksicheskogo deĭstviia karbofosa na fone polikhlorpinena.