Cytophotometric studies on mycosis fungoides and other cutaneous reticuloses.
Feulgen-DNA cytophotometry was carried out in skin imprint preparations of patients with mycosis fungoides, reticulum-cell sarcoma, lymphomatoid papulosis and Sézary's syndrome. These patients proved to have aneuploid and polyploid DNA histograms. In tumour stage of mycosis fungoides a more bimodal distribution of the DNA values was found. Of 79 cases of suspected malignant reticulosis of the skin, 32 showed an abnormal DNA histogram with 5 percent or more tetraploid and hypertetraploid cells. Thirty of these patients developed a malignant skin reticulosis during the 4-year follow-up period. It is concluded that DNA cytophotometry has value as a supplement to routine morphological histopathology in malignant cutaneous reticulosis.
D004273:DNA, Neoplasm / Q000032:analysis*; D003873:Dermatitis, Exfoliative / Q000378:metabolism; D006801:Humans; D008206:Lymphatic Diseases / Q000032:analysis*; D008223:Lymphoma / Q000032:analysis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000032:analysis*; D009182:Mycosis Fungoides / Q000032:analysis*; D010783:Photometry; D012878:Skin Neoplasms / Q000032:analysis*
D004273:DNA, Neoplasm