title: Trials with rafoxanide. 8. Efficacy of an injectable solution against trematodes and nematodes in cattle.
abstract: Four experiments are described in which the efficacy of an experimental 5% injectable solution of rafoxanide was evaluated against various adult and immature helminths in cattle. Subcutaneous injection at a dosage of 3 mg/kg live mass resulted in the following reductions in mean worm burdens: adult Fasciola hepatica, 82,6%; adult Fasciola gigantica, 99,8% immature Paramphistomum microbothrium, 10,1% adult Haemonchus placei, 99,6%, third stage H. placei, 73,7%; adult Bunostomum phlebotomum, 99,8%; adult Oesophagostomum radiatum, 99,9%; and fourth stage O. radiatum, 76,9%. At 5 mg/kg live mass, rafoxanide solution was 97,5% and 99,2% effective against 8-week old F. gigantica and third stage H. placei respectively and at 7,5 mg/kg, 92,4% against 6-week old F. gigantica.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary; D006725:Hookworm Infections / Q000188:drug therapy; D007279:Injections, Subcutaneous; D008297:Male; D009349:Nematode Infections / Q000662:veterinary*; D009814:Oesophagostomiasis / Q000188:drug therapy / Q000662:veterinary; D011888:Rafoxanide / Q000008:administration & dosage*; D012457:Salicylamides / Q000008:administration & dosage*; D014201:Trematode Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D012457:Salicylamides; D011888:Rafoxanide