[Mechanism of action of some quinoline alkaloids on respiratory chain of mitochondria].
The mechanism of action of some quinoline alkaloids and their derivatives on respiratory chain of rat liver and Candida lipolytica yeast mitochondria was studied. The alkaloids were shown to inhibit electron transfer in the respiratory chain. The site of their action is localized between b and c cytochromes. Besides their ability to inhibit electron transfer in the respiratory chain, alkaloids are shown to be specific inhibitors of "exogenous" NADH-dehydrogenase of C. lipolytica yeast mitochondria. In addition to their inhibiting properties alkaloids can stimulate ATPase activity of mitochondria. O-alkylation of pseudane-IX permits to differentiate the inhibiting and uncoupling properties of this alkaloid.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002175:Candida / Q000187:drug effects / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism; D004579:Electron Transport / Q000187:drug effects; D004789:Enzyme Activation; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D014475:Uncoupling Agents / Q000494:pharmacology
D000470:Alkaloids; D003580:Cytochromes; D011804:Quinolines; D014475:Uncoupling Agents; D009247:NADH, NADPH Oxidoreductases; D000251:Adenosine Triphosphatases
Mekhanizm deĭstviia alkaloidov riada khinolina na dykhatel'nuiu tser mitokhondriĭ