The effect of some drugs on the urinary excretion of some aryl alkyl amines in the rat.
The urinary excretion levels of meta tyramine (mTA), para tyramine (pTA) and beta-phenylethylamine (PE) in the untreated rat have been established. The effects of intraperitoneal injections of a precursor (L-Dopa) and some inhibitors of monoamine oxidation (pargyline), decarboxylation (Ro4-4602) and hydroxylation (iprindole, imipramine and para chlorophenylalanine (PCPA) are consistent with the interpretation that PE arises essentially as a result of decarboxylation of phenylalanine, pTA by hydroxylation of PE and mTA by dehydroxylation (and decarboxylation) of a catechol.
D000588:Amines / Q000652:urine*; D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007488:Iprindole / Q000494:pharmacology; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D010627:Phenethylamines / Q000652:urine; D051381:Rats; D014439:Tyramine / Q000652:urine
D000588:Amines; D010627:Phenethylamines; D004295:Dihydroxyphenylalanine; D007488:Iprindole; D001545:Benserazide; D010293:Pargyline; D007099:Imipramine; D010134:Fenclonine; D014439:Tyramine