[Modifications by 1-eburnamonine and vincamine on 2,3-diphosphoglycerate blood levels in the presence or absence of histotoxic hypoxia produced by potassium cyanide in the awake rat].
The influence of 1-éburnamonine (1-E) and vincamine (Vi) on 2,3-disphosphoglycerate (2,3-DPG) blood level was investigated in awake rats when cyanide (KCN) induced hypoxia was present or not. Used alone, KCN, 1-E and Vi (i.p. route) increased 2,3-DPG blood level. Used with KCN, 1-E or Vi produced a very more important increase of 2,3-DPG than that observed when both drugs were used alone. In all cases, the observed increase was attributed to red cells 2,3-DPG since hematocrite, red-cells count and hemoglobin level were unmodified. The results suggest that the KCN induced increase of 2,3-DPG constitutes a response to hypoxia. On the contrary, that of 1-E or Vi seems to be the result of a metabolic stimulation and could explain in part their antihypoxic properties previously described at cerebral level.
D000818:Animals; D003486:Cyanides / Q000494:pharmacology*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004357:Drug Synergism; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011190:Potassium Cyanide / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014749:Vincamine / Q000494:pharmacology*
D003486:Cyanides; D004163:Diphosphoglyceric Acids; D014748:Vinca Alkaloids; D014749:Vincamine; D011190:Potassium Cyanide
Modifications par la 1-éburnamonine et la vincamine du taux sanguin de 2,3-diphosphoglycérate en présence ou en l'absence de l'hypoxie histotoxique provoquée par le cyanure de potassium chez le rat éveillé.