Strong expression of Fc-receptors on leukemic cells in hairy cell leukemia.
The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fc-receptor actitivy on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of 125I-labelled aggregated IgG under saturation conditions, it was found that the hariy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound 125I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4 degrees C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20 degrees C.
D001666:Binding Sites, Antibody; D002448:Cell Adhesion; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000032:analysis*; D007074:Immunoglobulin G / Q000378:metabolism; D008206:Lymphatic Diseases / Q000276:immunology*; D009000:Monocytes / Q000276:immunology
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G