Effect of intrahepatically implanted islets of Langerhans on hepatic function in the rat.
Diabetes mellitus is satisfactorily controlled in the rat by hepatic implantation of isolated, isologous pancreatic islets.  The transplanted islets appear to be viable for at least 6 months after implantation, and hepatic function studies (serum bilirubin, alkaline phosphatase, glutamic-oxalacetic transaminase, prothrombin time) and microscopic examination indicate that they do not interfere with hepatic function.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D016381:Islets of Langerhans Transplantation; D008099:Liver / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013311:Streptozocin; D013997:Time Factors; D014184:Transplantation, Homologous
D001786:Blood Glucose; D013311:Streptozocin; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase