Steroid metabolism of foetal tissues. I. Metabolism of pregnenolone-4-14C by human foetal ovaries.
The metabolism of pregnenolone-4-14C of ovaries from human foetuses ranging in age from the 14th through the 42th week of gestation was studied by a double isotope method in vitro. Progesterone was found as the main metabolite. The rate of conversion is correlated with histochemical findings of the same material and comparison with the FSH- and LH-concentration in human foetal pituitaries is made. As further metabolites only 17alpha-hydroxypregnenolone and dehydroepiandrosterone were isolated. For comparison tissue from a polycystic ovary was investigated with the same method.
D006907:17-alpha-Hydroxypregnenolone / Q000096:biosynthesis; D000367:Age Factors; D000735:Androstenedione / Q000096:biosynthesis; D003687:Dehydroepiandrosterone / Q000096:biosynthesis; D004958:Estradiol / Q000096:biosynthesis; D004970:Estrone / Q000096:biosynthesis; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D006908:Hydroxyprogesterones / Q000096:biosynthesis; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008297:Male; D010048:Ovarian Cysts / Q000378:metabolism; D010053:Ovary / Q000196:embryology / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism; D011284:Pregnenolone / Q000378:metabolism*; D011374:Progesterone / Q000096:biosynthesis; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis
D006908:Hydroxyprogesterones; D004970:Estrone; D006907:17-alpha-Hydroxypregnenolone; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D011284:Pregnenolone; D006913:Hydroxysteroid Dehydrogenases