Descriptive epidemiology of small-bowel atresia in metropolitan Atlanta.
The epidemiological characteristics are presented of 46 children with small-bowel atresia, ascertained over a 6-year period by an active, population-based birth defect surveillance program in Atlanta, Georgia. The malformation occurred at a rate of 2.7/10,000 livebirths. The previously reported association of duodenal atresia and Down syndrome was confirmed was confirmed. No instances of familial association were noted, nor was any excessive prenatal exposure to drugs found. Thirty-two instances of isolated small-bowel atresia were analyzed in detail. The frequency of the isolated defect for blacks was twice that for whites because of a higher rate for black females. The isolated defect was commonest in the winter months. The relation between isolated small-bowel atresia, birth weight, and mortality was discussed. This small series cannot readily be subdivided into distinct epidemiological groups on the basis of the location of the atretic lesions along the length of the small bowel.
D044383:Black People; D004314:Down Syndrome / Q000150:complications; D005260:Female; D005845:Georgia; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D011159:Population Surveillance; D012621:Seasons; D001741:Black or African American