Glomerular fibrinolytic activity after thrombin perfusion in the rat.
The effects of thrombin perfusion on glomerular fibrinolytic activity (GFA) have been assessed quantitatively in isolated rat glomeruli. Gfa was augmented by increasing total thrombin perfused to a maximal dose of 120 units per 100 gm. Fifty per cent maximal GFA occurred at a dose of 38 to 42 units of thrombin per 100 gm. independent of duration or rate of perfusion. After termination of infusion, GFA diminished and thrombi were no longer observed. Simultaneous administration of thrombin and epsilon-aminocaproic acid was associated with sustained high GFA and persistence of thrombi, presumably due to inhibition of the action of plasmin on fibrin, but it had no effect on tissue activators of plasminogen.
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D003864:Depression, Chemical; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005337:Fibrin / Q000378:metabolism; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D005342:Fibrinolysis / Q000187:drug effects*; D007263:Infusions, Parenteral; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism; D009392:Nephrectomy; D010958:Plasminogen / Q000378:metabolism; D051381:Rats; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology*
D000614:Aminocaproates; D005337:Fibrin; D010958:Plasminogen; D013917:Thrombin; D005341:Fibrinolysin