Emergence of foreign H-2-like cytotoxicity and transplantation targets on vaccinia and Moloney virus-infected Meth. A tumour cells.
Using cytotoxic effector cells of different anti-H-2 specificities, new cell-mediated lympholysis targets, normally undetected on Meth. A tumour cells, were shown after passage with vaccinia or Moloney virus. The H-2d CML targets on Meth. A cells recognized by B10.BR anti-B10.D2 effector cells were presented only after simultaneous vaccinia virus passage, while passage with Moloney virus caused the emergence of H-2b targets. Small but significant killing of vaccinia virus-passaged Meth.A was also obtained by anti-H-2k effector cells. These results are discussed in relation to in vivo experiments: retardation of tumour growth was noted in mice which had received several injections of vaccinia or Moloney virus, showing that the new CML targets were probably acting as transplantation targets.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014412:Tumor Virus Infections / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology*
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D037102:Lectins