Nucleoside triphosphate levels in Streptomyces hydrogenans during growth and induction of 20beta-hydroxysteroid dehydrogenase.
Levels of the purine nucleoside triphosphates are decreasing towards the end of log phase growth of Streptomyces hydrogenans. Induction of 20beta-hydroxysteroid dehydrogenase by addition of 11beta,21-dihydroxy-4,17(20)-pregnadien-3-one to the growth medium leads to a pronounced drop in purine nucleoside triphosphate levels with is irreversible in contrast to the initial loss and later accumulation of RNA.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D003349:Cortisone Reductase / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006913:Hydroxysteroid Dehydrogenases / Q000096:biosynthesis*; D011245:Pregnadienes / Q000494:pharmacology; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D013302:Streptomyces / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*
D011245:Pregnadienes; D012333:RNA, Messenger; D012313:RNA; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D006913:Hydroxysteroid Dehydrogenases; D003349:Cortisone Reductase