Steroidogenesis in cerebral metastatic chorionepithelioma tissue in vitro.
Homogenates of cerebral metastatic chorionepithelioma tissue were incubated with labelled dehydroepiandrosterone, pregnenolone or 20alpha-hydroxypregn-4-en-3-one. The metabolites of dehydroepiandrosterone which were isolated and identified were androstenedione, testosterone, oestrone, and oestradiol; no oestriol was detected. The only metabolite of pregnenolone and 20alpha-hydroxypregn-4-en-3-one isolated and identified was progesterone. No conversion of C-21 to C-19 steroids occurred in the metastatic chorionepithelioma tissue.
D006907:17-alpha-Hydroxypregnenolone / Q000378:metabolism; D000735:Androstenedione / Q000096:biosynthesis; D001932:Brain Neoplasms / Q000378:metabolism*; D002822:Choriocarcinoma / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism; D004958:Estradiol / Q000096:biosynthesis; D004964:Estriol / Q000378:metabolism; D004970:Estrone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009362:Neoplasm Metastasis; D011247:Pregnancy; D011374:Progesterone / Q000096:biosynthesis; D013256:Steroids / Q000096:biosynthesis*; D013739:Testosterone / Q000096:biosynthesis
D013256:Steroids; D004970:Estrone; D006907:17-alpha-Hydroxypregnenolone; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D004964:Estriol