[Clinical evaluation of cardiovascular reactions to renal contrast media using an impedance method (author's transl)].
The hemodynamic changes during intravenous urography were studied in 120 non-selected patients (60 patients with bolus injection, 60 with infusion: 30 of each group with methylglucamine ioxitalamate, while the other 30 with sodium methylglucamine diatrizoate). There was a uniform statistically significant increase in heart rate (p less than 10(-9) as well as in cardiac output (p less than 10(-9)) (measured by means of a non-invasive impedance method). The observed changes were more marked following bolus injection than infusion. With the application of methylglucamine ioxitalamate the increase in heart rate, but not in cardiac output, was significantly less (p less than 0,01) than with that of sodium methylglucamine diatrizoate.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous / Q000379:methods; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D013997:Time Factors; D014567:Urography
D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007482:Iothalamate Meglumine
Die klinische Prüfung kardiovaskulärer Reaktionen auf nephrotope Kontrastmittel unter Anwendung der Impendanz-Methode