[Effects of aminoguanidine sulfate on hepatic and blood levels of histamine after partial hepatectomy in rats].
Known as a specific inhibitor of histaminase, amino-guanidin sulfate has been administered subcutaneously to Wistar rats immediately after partial hepatectomy, then once in 16 hours until 80 hours. It has thus provoked: an initial rise of the hepatic and blood rates of histamin, which is transient and reaches its apex 6 hours after the operation; then, a new rise of these rates, which lasts and even is, in percentage, maximum at 72 hours. Therefore, amino-guanidin sulfate is available to estimate the influence of the endogenous histamin upon liver regeneration.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D006498:Hepatectomy; D006632:Histamine / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects*; D051381:Rats
D006146:Guanidines; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing)
Action du sulfate d'aminoguanidine sur les taux hépatique et sanguin de l'histamine après hépatectomie partielle chez le Rat.