[Histochemical study of carbonic anhydrase and HCO3(-)-stimulated adenosine triphosphatase in the rat stomach during hydrochloric acid secretion].
By means of histochemical methods it was established that carboanhydrase of the parietal cells of fundal glands and HCO-3 stimulated ATP-ase of the rat's gastric mucosa capillaries disposed next to the parietal cells were activated by food and histamine. The obtained data confirm the idea of the multicellular functional essembly sustaining HCL secretion (R. I. Salganik, 1974). Should gastrin induce the formation of histamine in endocrinous cells and the histamine activate carboanhydrase in parietal cells, our data confirm the supposition that HCO-3-ions stimulate ATP-ase sustaining the exchange between HCO-3-cells and C1- of blood to form HCl in the endothelial cells of blood capillaries adjacent to the parietal cells.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002196:Capillaries / Q000201:enzymology; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005215:Fasting; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000166:cytology / Q000201:enzymology; D008297:Male; D051381:Rats; D013270:Stomach / Q000098:blood supply / Q000201:enzymology*; D013997:Time Factors
D000251:Adenosine Triphosphatases; D002256:Carbonic Anhydrases
Gistokhimicheskoe issledovanie karboangidrazy i HCO3(-)-stimuliruemoĭ adenozintrifosfatazy v zheludke krys pri sekretsii solianoĭ kisloty