The methylation of DNA in regenerating rat liver.
There was more persistent methylation of liver DNA from rats given [14C]DMN if it was given during liver regeneration, either after partial hepatectomy or a dose of CCl4 compared to otherwise untreated rats. During liver regeneration, DMN metabolism was slowed making the active metabolites available for longer.
D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D008745:Methylation; D009602:Nitrosamines / Q000009:adverse effects / Q000378:metabolism; D051381:Rats
D009602:Nitrosamines; D004247:DNA; D002251:Carbon Tetrachloride