Brain serotonin and epileptic seizures in mice: a pharmacological and biochemical study.
5-Hydroxytryptophan (5-HTP) reduced the intensity of both audiogenic and pentylenetrazol seizures. p-Chlorophenylalanine reduced audiogenic seizure (AGS) susceptibility but failed to change the pentylenetetrazol seizure (PTS). Drugs blocking brain serotonin (5-HT) receptors suppressed AGS but caused no clear effects upon PTS. Pentylenetetraziol-induced shock increased brain 5-hydroxyindoleacetic acid (5hiaa) concentrations and decreased 5-HT levels. Single audiogenic shock decreased the acumulation of 5-HT and 5-HIAA in the brains of mice pretreated with 5-HTP. On the other hand PTS increased the accumulation of 5-HT and 5-HIAA in the brains of mice pretreated with 5-HTP. It is suggested that AGS decrease brain 5-HT turnover whilst PTS cause an opposite effect.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry; D003864:Depression, Chemical; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D006317:Hearing Loss, Noise-Induced / Q000209:etiology; D051379:Mice; D010433:Pentylenetetrazole; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D006916:5-Hydroxytryptophan; D010134:Fenclonine; D010433:Pentylenetetrazole