[Lack of concordance in the effect of large doses of phenformin on insulin secretion and glycemia. Tentative analysis].
In the anesthetized dog normal or pretreated with phenformin (20 mg/kg per os) for 7 days, a subcutaneous injection of this biguanide (20 mg/kg) triggers a considerable hyperinsulinemia without concomitant hypoglycemia. The insulin secreted by these animals is biologically active on rat epididymal fat pads. On the other hand, epididymal fat pads of rats pretreated with phenformin display a lower response to insulin than that of non treated rats. The hypoglycemic effect of the same dose of insulin is less important in the normal dog after chronic pretreatment with phenformin.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001681:Biological Assay; D001786:Blood Glucose / Q000378:metabolism*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D010629:Phenformin / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D010629:Phenformin
Absence de concordance entre les effets sur l'insulino-sécrétion et la glycémie de la phenformine à fortes doses. Tentative d'analyse.