Microbial transformation of artificial estrogens of the allenolic group.
When 2,2-dimethyl 3-(2'-naphthyl 6'-hydroxy) pentanoic acid, an artificial estrogen of the allenolic acid group, was added to an exponential-phase growth culture of Neurospora crassa (in Horowitz medium), it was transformed into its hydroxylated derivative, 2,2-dimethyl 3-(2'-naphthyl 4',6'-dihydroxy)pentaoic acid. To study this transformation, radioactive 2-methyl-[2-14-C=A1methyl 3-(2'-naphthyl 6'-hydroxy) pentanoic acid has been prepared. The rate of metabolism of allenolic acids varies in the same way as their estrogenic activity.
D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D045166:Estradiol Congeners / Q000378:metabolism*; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000378:metabolism*; D010421:Pentanoic Acids / Q000096:biosynthesis / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D014631:Valerates / Q000378:metabolism*
D002250:Carbon Radioisotopes; D045166:Estradiol Congeners; D010421:Pentanoic Acids; D014631:Valerates