[Effect of theophylline on the glomerular pathway of ferritin macromolecules in rats].
The present microscopic study evaluates the quantitative variations of ferritin particules density within the glomerular ultrastructures after theophyllin perfusion in the Rat. The ferritin particules density increases 3,65 times in the glomerular basement membrane and decreases 3,28 times in the glomerular capillary lumen. So, theophyllin increases considerably the glomerular pathway of the protein macromolecules. This results confirm the increased volumic flow (Jv) and macro-solutes flow (Js') noted with clearance methods and urinary excretion studies.
D000818:Animals; D001485:Basement Membrane / Q000187:drug effects / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010477:Perfusion; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*
D005293:Ferritins; D013806:Theophylline
Influence de la théophylline sur le passage transglomérulaire des macromolécules de ferritine chez le Rat.