The effect of acetyldexphenmetrazine and dexphenmetrazine on the susceptibility to audiogenic seizures in mice.
The antiepileptic effect of dexphenmetrazine (DP) and acetyldexphenmetrazine (ADP) was tested on audiogenic seizures in a 100% susceptible strain of mice. DP had no antiepileptic effect, however, it markedly suppressed the postparoxysmal motor inhibition. ADP had a distinct anticonvulsive effect--it suppressed the convulsive component of the seizure, leaving its running component unaffected. The results are compared with the effect of both drugs on electrographic epileptic phenomena in the turtle brain (Servít and Strejcková 1976).
D000161:Acoustic Stimulation; D000818:Animals; D051379:Mice; D010633:Phenmetrazine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology
D010633:Phenmetrazine