The influence of antiserotonergic agents on the action of dopaminergic drugs.
The effect of drugs blocking serotonin receptors: cyproheptadine, methysergide, and methergoline, and of serotonin synthesis inhibitor, p-chlorophenylalanine on the stereotyped behavior and number of rearings of the rats receiving apomorphine, amphetamine, nomifensine and 1,3-dimethyl-5-aminoadamantane was investigated. The blockade of serotonin receptors potentiates behavioral effects of dopamine agonists. It is concluded that central serotonin may play an inhibitory role, antagonistic to that of catecholamines.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004347:Drug Interactions; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D008559:Memantine / Q000494:pharmacology; D008711:Metergoline / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000096:biosynthesis; D012702:Serotonin Antagonists; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D007546:Isoquinolines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008711:Metergoline; D003533:Cyproheptadine; D012701:Serotonin; D001058:Apomorphine; D010134:Fenclonine; D003913:Dextroamphetamine; D004298:Dopamine; D008559:Memantine; D008784:Methysergide