title: Potential clinical uses of short-acting nondepolarizing neuromuscular-blocking agents as predicted from animal experiments.
abstract: It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents. The authors have investigated the actions of several short-acting nondepolarizing ester neuromuscular-blocking drug in comparison with succinylcholine, and theri interactions with d-tubocurarine, and inhibitors of true and plasma cholinesterase. Two experimental agents, HH-85 and JJ-142, are examples. Tests in animals suggest areas of extrapolation to  human use.
mesh_terms: D000818:Animals; D002415:Cats; D004285:Dogs; D004347:Drug Interactions; D000882:Haplorhini; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced; D011188:Potassium / Q000097:blood; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology; D013997:Time Factors; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D000644:Quaternary Ammonium Compounds; D013390:Succinylcholine; D011188:Potassium; D014403:Tubocurarine