[(Whole body plethysmographic studies on the bronchospasmolytic effect of injectabls drugs. Comparison of aminophylline, diprophylline and hexoprenaline)].
The bronchodilator effect of intravenously administered drugs was tested by whole bodyplethysmography in 24 patients with chronic obstructive airway disease over a period of 60 min. Subsequent to this, another bronchodilator was applied by a metered dose inhaler. Aminophylline (0,24 g i.v.) was followed by a decrease of airway resistance to a maximum of 73,04% of the base line value after 30 min. and to 76,33% after 60 min; inhalation of fenoterol (0,4 mg) caused a further decrease to 47,33% after 20 min. Diprophylline (0,28 gi.v.) produced only a slight decrease to a maximum of 95,75% after 20 min. and to 99,54% after 60 min.; fenoterol (0,4mg) reduced airway resistance to 55,29%. Hexoprenaline (0,005 mg i.v.) was followed by a decrease to a maximum of 74,71% after 5 min. and to 92,83% after 60 min.; ipratropiumbromide (0,08 mg) caused a further decrease to 54,92%. A considerable increase of heart rate, from 89,25/min. to 106,15/min. occurred only after hexoprenaline. For intravenous bronchodilator therapy we prefer aminophylline. Optimal bronchodilation however, was seen only after further application of fenoterol or ipratropiumbromide by a metered dose inhaler.
D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects; D000628:Aminophylline / Q000627:therapeutic use*; D001980:Bronchi / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use; D006594:Hexoprenaline / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D009241:Ipratropium / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines / Q000627:therapeutic use*; D010993:Plethysmography, Whole Body; D013806:Theophylline / Q000031:analogs & derivatives* / Q000627:therapeutic use
D010627:Phenethylamines; D005280:Fenoterol; D000628:Aminophylline; D013806:Theophylline; D006594:Hexoprenaline; D009241:Ipratropium
Bodyplethysmographische Untersuchungen über den bronchospasmolytischen Effekt injizierbarer Pharmaka. Vergleich von Aminophyllin, Diprophyllin und Hexoprenalin