Immunohistological investigation of N-acetylserotonin in the rat cerebellum after parachlorophenylalanine treatment.
The amount of N-acetylserotonin (NAS) in the granule layer of the rat cerebellum was investigated using immunolohistologic double antibody technique. After 5 days of treatment with parachlorophenylalanine (PCPA) an increase of NAS was observed. The possibility of a differential effect of PCPA on serotonin synthesis in the neurons and the nerve terminals is discussed.
D000818:Animals; D002525:Cerebellar Cortex / Q000187:drug effects / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000096:biosynthesis; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism
D012701:Serotonin; D008550:Melatonin; D010134:Fenclonine