[Changes, induced by certain flavonoids, of the hypotensive effects of arachidonic acid].
In the rat, silybine and Z 12007, a derivative of rutoside, increase the vasodepressive activities of arachidonic acid, a prostaglandin precursor. They reduce the activity of PGE2. Quercetine also increases the hypotensive action of arachidonic acid. These three flavonoids are supposed to increase the prostaglandin biosynthesis.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001794:Blood Pressure; D005419:Flavonoids / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D012431:Rutin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012838:Silymarin / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D001095:Arachidonic Acids; D005419:Flavonoids; D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic; D012838:Silymarin; D012431:Rutin; D011794:Quercetin
Modifications, par certains flavonoïdes, des effets hypotenseurs de l'acide arachidonique.