Effect of water-soluble adjuvants on in vitro lymphocyte immunization.
Water-soluble adjuvants prepared from Mycobacteriim smegmatis and human mixed mycobacteria strains C, DT, and PN were found to increase lymphocyte response in one-way mixed-lymphocyte culture and in vitro immunization to cultured human tumor cells. Phytohemagglutinin-induced lymphocyte blastogenesis, however, was depressed by water-soluable adjuvants.
D000276:Adjuvants, Immunologic; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D037102:Lectins; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology; D009369:Neoplasms / Q000276:immunology
D000276:Adjuvants, Immunologic; D037102:Lectins