Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents.
Rats treated with di(2-chloroethyl)methylamine (HN2), N-methyl-N-nitrosourea (MNUA) and N-ethyl-N-nitrosourea (ENUA) excrete significantly larger amounts of deoxycytidine (dC) and thymidine in their urine 0-24 h after treatment. Ethyl methanesulphonate (EMS) and dimethylnitrosamine (DMN) gave negative results in this respect but all five alkylating agents increased the excretion of 1-methyl-nicotinamide (1-meNmd). In addition, a larger quantity of 7-methylguanine (7MG) and uric acid was excreted after DMN treatment. 1,4-Dimethanesulphonoxybutane (myleran), 2,2-dichlorovinyl dimethyl phosphate (dichlorvos), 5-fluorouracil (5FU), cytosine arabinoside (araC), 2-acetylaminofluorene (AAF) and 7-bromomethylbenz-[a]anthracene (7-BrMBA) gave negative results.
D015073:2-Acetylaminofluorene / Q000494:pharmacology; D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D002066:Busulfan / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003561:Cytarabine / Q000494:pharmacology; D003841:Deoxycytidine / Q000652:urine*; D004006:Dichlorvos / Q000494:pharmacology; D004128:Dimethylnitrosamine / Q000494:pharmacology; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006842:Hydrocarbons, Brominated / Q000494:pharmacology; D008466:Mechlorethamine / Q000494:pharmacology; D008760:Methylguanidine / Q000652:urine; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000652:urine*; D009607:Nitrosourea Compounds / Q000494:pharmacology; D051381:Rats; D013936:Thymidine / Q000652:urine*; D014527:Uric Acid / Q000652:urine
D000477:Alkylating Agents; D001551:Benz(a)Anthracenes; D006842:Hydrocarbons, Brominated; D009607:Nitrosourea Compounds; D003561:Cytarabine; D003841:Deoxycytidine; D009536:Niacinamide; D014527:Uric Acid; D008466:Mechlorethamine; D008760:Methylguanidine; D004006:Dichlorvos; D005020:Ethyl Methanesulfonate; D015073:2-Acetylaminofluorene; D002066:Busulfan; D004128:Dimethylnitrosamine; D005472:Fluorouracil; D013936:Thymidine