[Study of the effect of ethaverine and papaverine on post-ischemic arrhythmias in the awake dog].
Influence of ethaverine was compared to papaverine on the development of dysrhythmias observed in the unanesthetized dog following coronary ligation. Papaverine generally induced the reappearance of ectopic beats. In most cases, ethaverine induced the normalization of the electrocardiogram. This favourable effect of ethaverine distinguished it from papaverine; however it was moderate, transient and weaker than that of classical antidysrhythmic drugs. According to these results and those of previous experimental data, ethaverine seems to be devoid of "malignant properties".
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000150:complications; D004285:Dogs; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D010208:Papaverine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D010208:Papaverine
Etude des effets de l'éthavérine et de la papavérine sur les dysrythmies post-ischémiques chez le chien éveillé.