The influence of some sympatholytic, parasympatholytic and serotonin-synthesis-inhibiting agents on the ultrastructure of the rabbit pineal organ.
The influence of certain drugs on the ultrastructure of rabbit pinealocytes was studied. The results obtained after administration of p-chlorophenylalanine and p-chloroamphetamine support the hypothesis proposed earlier that the smooth endoplasmic reticulum in the light pinealocytes is involved in indoleamine synthesis. The administration of either one of the sympatholytic agents, 6-hydroxydopamine or alpha-methyl-p-tyrosine, induced typical fine structural changes corresponding to those observed after surgical sympathectomy.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006056:Golgi Apparatus / Q000648:ultrastructure; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011433:Propranolol / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000096:biosynthesis; D012702:Serotonin Antagonists; D013565:Sympatholytics / Q000494:pharmacology*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D006892:Hydroxydopamines; D008781:Methyltyrosines; D010276:Parasympatholytics; D011743:Pyrimidines; D012702:Serotonin Antagonists; D013565:Sympatholytics; D012701:Serotonin; D010133:p-Chloroamphetamine; D001285:Atropine; D012110:Reserpine; D011433:Propranolol; D006916:5-Hydroxytryptophan; D010134:Fenclonine