Increased sodium reabsorption postuninephrectomy: evidence for a humoral factor.
Natriuresis occurs in the immediate postnephrectomy period. Yet in the days and weeks that follow, increased Na-K-ATPase (sodium-potassium activated adenosine triphosphate) activity, oxygen consumption and sodium reabsorption occur. Increased sodium reabsorption probably occurs early postuninephrectomy but is obscured by passive hemodynamic and physical-chemical factors that induce natriuresis. These factors were controlled in isolated canine kidneys perfused with normal and twenty-four-hour postuninephrectomized blood. A substance that increases sodium reabsorption and glomerular filtration rate in the kidneys perfused with uninephrectomized blood was demonstrated. The relationship between this and a hormonal substance that induces compensatory renal hypertrophy is unknown. The use of this hormone for treatment of renal failure is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D009318:Natriuresis; D009392:Nephrectomy; D009997:Osmotic Pressure; D010101:Oxygen Consumption; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014655:Vascular Resistance
D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium