Rise in dehydroepiandrosterone and oestrogens during clomiphene administration in normal men.
Serum concentrations of LH, FSH and testosterone, and urinary excretion of individual 17-ketosteroids, oestrogenic substances and free cortisol was investigated in 12 normal men after a daily administration of 50 mg clomiphene citrate for 14 days. A significant increase in the serum concentrations of LH, FSH and testosterone was seen after 8 days with a further increase when measured a week later. The percentual increase in urinary excretion of oestrogens and dehydroepiandrosterone was of the same order as the increase in serum testosterone concentrations whereas the increase in androsterone and a aetiocholanolone was significantly lower. The excretion of free cortisol was unaltered. The study that measurements of oestrogens in the urine might be used as a parameter of the stimulatory effect of clomiphene on the hypothalamic - pituitary - gonadal axis in man. In addition, of the results support the hypothesis of an independent effect of clomiphene on adrenal steroidogenesis, not related to the production of glucocorticoids.
D015068:17-Ketosteroids / Q000652:urine; D000328:Adult; D000738:Androsterone / Q000652:urine; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D003687:Dehydroepiandrosterone / Q000652:urine*; D004967:Estrogens / Q000652:urine*; D005043:Etiocholanolone / Q000652:urine; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013268:Stimulation, Chemical; D013739:Testosterone / Q000097:blood
D015068:17-Ketosteroids; D004967:Estrogens; D002996:Clomiphene; D013739:Testosterone; D003687:Dehydroepiandrosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005043:Etiocholanolone; D000738:Androsterone; D006854:Hydrocortisone