[Study of the antihypoxic effect of eburnamonine in acute and recurrent anoxia on the cerebral electric activity in curarized rats. Comparison with vincamine].
Using venous infusion (0.25 mg/kg min.), l-eburnamonine decreases the electroencephalographic modifications induced by acute asphyxic anoxia in curarized rats. This activity appears when the total dose administrated before the first asphyxia is approximatively 5 mg/kg. In such conditions, its protective activity is precocious and long lasting. In the same experimental conditions, vincamine assumes a protective activity only during a short time. The results are discussed in terms of selectivity of the method used and in terms of cerebral antihypoxic properties of l-eburnamonine.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003864:Depression, Chemical; D004569:Electroencephalography; D000860:Hypoxia / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D051381:Rats; D014748:Vinca Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use
D014748:Vinca Alkaloids
Etude de la protection exercée par la l-éburnamonine vis-à-vis de l'anoxie asphyxique alguë et itérative sur l'activité électrique cérébrale du rat curarisé. Comparaison avec la vincamine.