[Alkylating compounds, inhibitors of mitochondrial ATP-synthetase].
The esters of aromatic acids with two electrophilic groups were found to inhibit mitochondrial ATP-synthetase like oligomycin. The substances without electrophilic sites or with one electrophilic groups have no the oligomycin-like effect on mitochondria. Aromatic acids with two alkylating groups are also inefficient.
D000244:Adenosine Diphosphate; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000255:Adenosine Triphosphate; D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004794:Enzyme Repression / Q000187:drug effects; D005021:Ethylamines / Q000494:pharmacology; D008928:Mitochondria / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship
D000477:Alkylating Agents; D005021:Ethylamines; D009097:Multienzyme Complexes; D009840:Oligomycins; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010770:Phosphotransferases; D000251:Adenosine Triphosphatases
Alkiliruiushchie soedineniia--ingibitory ATP-sintetazy mitokhondriĭ