Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake.
Rats treated with Lilly 110140, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. Lilly 110140 antagonizes the hyperalgesia following injections of p-chlorophenylalanine and potentiates morphine analgesia. Naloxone blocks the analgesia following morphine, but has no effect on Lilly 110140-induced analgesia. Brain serotonin neurons may, at least in part, mediate analgesia.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003864:Depression, Chemical; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010647:Phenyl Ethers / Q000494:pharmacology; D011437:Propylamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D000700:Analgesics; D010647:Phenyl Ethers; D011437:Propylamines; D012701:Serotonin; D009270:Naloxone; D006897:Hydroxyindoleacetic Acid; D009020:Morphine; D010134:Fenclonine