Development of spontaneous motility in chick embryos. Sensitivity to aminergic transmitters.
The consequences of systemic administration of aminergic transmitters (n-adrenaline 16 microgram/kg egg weight; serotonin 2.5 and 5 mg/kg e.w.; dopamine 2.5 and 5 mg/kg e.w.) for the spontaneous motility and heart rate of 11- to 19-day chick embryos were studied intack eggs. The following results were characteristic for all three transmitters: a) when administered to 11- and 13-day embryos their effect was non-significant; the first signs of activity did not appear until the 15th day of incubation. The effect on 17- and 19-day embryos was stronger. b) After the 15th day of incubation, all these transmitters had a predominantly inhibitory effect on spontaneous motility; in 17- and 19-day embryos this acquired a periodic character. c) The changes in spontaneous motility did not correlate significantly in any way with the relatively small heart rate changes.  It is concluded from the results that aminergic mechanisms begin to participate in regulation of the spontaneous motility of chick embryos from the 15th day of incubation, and not before.
D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002642:Chick Embryo / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D001679:Biogenic Amines; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine