[Action of an antiestrogen agent, tamoxifen on the uterus and vagina of the ovariectomized rat].
Tamoxifen has more or less strong estrogen influence according to the targets : a light one on the uterus (1 mg being much less strong than 0.25 microgram of estradiol), a dynamic one on the vagina (50 microgram of tamoxifen make the vagina open in as short a time as 0.25 microgram of estradiol do but the keratinisation is still not completed even with 1 mg of tamoxifen). We can still see this influence four days after the end of the treatment. This influence is weak on the uterus until the 11 th day and it is much stronger on the vagina until about the 8 th day. Tamoxifen has an antiestrogenic action when opposed to 20 microgram of estradiol : this action is limited as soon as you give a dosis of 50 microgram on the uterus and it is nearly total with a dose of 1 mg ; we can notice it on the vaginal only from 200 microgram on.
D000818:Animals; D002369:Castration; D004965:Estrogen Antagonists; D005260:Female; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
D004965:Estrogen Antagonists; D013267:Stilbenes; D013629:Tamoxifen
Action d'un anti-estrogène, le tamoxifène, sur l'utérus et le vagin de la ratte ovariectomisée.