A case of T-cell lymphoma with Sézary cells in the blood and bone marrow accompanied by peripheral T and B lymphocytosis.
A case of T-cell lymphoma occurred in a man, aged 66, whose symptoms started as itching and the appearance of 1-2 cm indurated plaques with central pustules on the skin of the trunk and face. A few months later generalized lymphomas and splenomegaly were present. Investigations of the lymphocytic subpopulations in situ in fresh frozen sections of lymphomas and skin showed only T cells. Samples of blood and bone marrow disclosed lymphocytosis and Sézary cells. Both T and B lymphocytes were definitely increased in the blood. The value of tissue studies in analyzing lymphocytic subpopulations is emphasized as a differential diagnostic aid in classifying lymphomas. A relationship between the T-cell neoplasia and the T and B lymphocytosis to mycosis fungoides and the Sézary syndrome is discussed.
D000368:Aged; D001402:B-Lymphocytes / Q000648:ultrastructure; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D003873:Dermatitis, Exfoliative / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D008206:Lymphatic Diseases / Q000097:blood; D008218:Lymphocytosis / Q000150:complications / Q000209:etiology*; D008223:Lymphoma / Q000097:blood* / Q000150:complications; D008297:Male; D012867:Skin / Q000648:ultrastructure; D013163:Splenomegaly / Q000150:complications; D013577:Syndrome; D013601:T-Lymphocytes / Q000648:ultrastructure