Effect of dopamine on airways conductance in normals and extrinsic asthmatics.
1 Specific conductance was measured before and after infused and/or inhaled dopamine in nine normal subjects and twelve patients with extrinsic bronchial asthma. 2 There was no significant change in conductance in either group. 3 The alpha-adrenergic receptor antagonist thymoxamine infused in combination with dopamine had no significant effect on conductance in three asthmatics. 4 It is concluded that dopamine has no acute effect on airways resistance and that specific dopamine receptors are unlikely to exist in human airways.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000402:Airway Obstruction / Q000503:physiopathology; D000403:Airway Resistance / Q000187:drug effects*; D001249:Asthma / Q000503:physiopathology*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D013948:Moxisylyte / Q000494:pharmacology; D013997:Time Factors
D000336:Aerosols; D013948:Moxisylyte; D004298:Dopamine