title: Genetic control of phosphate-metabolizing enzymes in Neurospora crassa: relationships among regulatory mutations.
abstract: In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1, pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pcon-c (constitutive) mutations reside in the same cistron. preg-c (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D005809:Genes, Regulator; D005815:Genetic Code; D008040:Genetic Linkage; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology*; D009876:Operon; D010641:Phenotype; D010710:Phosphates / Q000378:metabolism*; D011995:Recombination, Genetic
chemical_list: D026901:Membrane Transport Proteins; D010710:Phosphates; D000469:Alkaline Phosphatase