Immune response-associated antigens on mouse leukemia cells. II. Anti-Ia sera inhibit the MLR reaction between normal GR spleen cells and syngeneic spleen cells of GRSL tumor-bearing mice.
Mitomycin C-treated ascites cells of Ia antigen-positive GRSL14 tumor cells and spleen cells from GRSL14 tumor-bearing mice stimulated lymphocyte proliferative responses in normal syngeneic GR spleen cells. Furthermore, mitomycin C-treated T cells purified from spleen cells of tumor-bearing mice also stimulated normal GR spleen cells. Anti-Ia sera inhibited the stimulating ability of tumor cells and of spleen cells of tumor-bearing mice. These data suggest a role for I region gene products in immune surveillance for syngeneic tumors.
D000818:Animals; D000941:Antigens; D001667:Binding, Competitive; D005802:Genes, MHC Class II; D007106:Immune Sera / Q000494:pharmacology*; D007109:Immunity; D007942:Leukemia, Experimental / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000276:immunology*
D000941:Antigens; D007106:Immune Sera