[In vitro effect of serotonin on the enzyme activities of glutamate decarbosylase and GABA transaminase at the level of acellular preparations of rat mesencephalon synaptosomes].
The effect of serotonin on glutamate decarboxylase and GABA-transaminase was studied, in vitro, in synaptosome homogenates from rat mesencephalon. Serotonin dissolved in the incubation medium inhibits glutamate decarboxylase activity and stimulates GABA-transaminase activity.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008636:Mesencephalon / Q000201:enzymology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*; D000637:Transaminases / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid
D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D000637:Transaminases; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase
Effet, in vitro, de la sérotonine sur les activités enzymatiques de la glutamate décarboxylase et de la GABA-transaminase du nuveau de préparations acellulaires