Purification of immunosuppressive factors extracted from bovine spleen (lymphoid chalone). II. Biological activity.
A highly purified extract from bovine spleen (FA) possessing immunosuppressive capacity was studied. Its tissue specificity was analysed in vivo and in vitro and the main components of FA, the well-known nucleosides deoxycytidine, deoxyinosine and thymidine, were tested in vivo. It seems that the molecule responsible for the biological activity of FA is a new substance endowed with strong specific activity and that lymphoid tissue is highly sensitive to the inhibiting capacity of this purified fraction.
D000818:Animals; D002417:Cattle; D046508:Culture Techniques; D006131:Growth Inhibitors / Q000276:immunology* / Q000302:isolation & purification; D006968:Hypersensitivity, Delayed; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009928:Organ Specificity; D013154:Spleen / Q000032:analysis
D006131:Growth Inhibitors