Chlorpromazine photoallergy. Coexistence of immediate and delayed type.
A 54-year-old woman had a recurrent pruritic eruption in light-exposed areas. She had a combination of three types of hypersensitivity to chlorpromazine, ie, allergic contact dermatitis, photocontact dermatitis, and immediate allergic photosensitivity. Immediate wheal reactions were found after long-wave ultraviolet light irradiation at photopatch test and intradermal injection sites with chlorpromazine. These responses were differentiated from phototoxic reactions. A positive passive transfer reaction was also observed. To my knowledge, chlorpromazine photosensitivity of the immediate type has not been previously described.
D002746:Chlorpromazine / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced*
D002746:Chlorpromazine