[Carcinogenic activity of benzyl-nitrosourea (BzNH) in BD-rats (author's transl)].
Chronic weekly oral and subcutaneous administration of N-Benzyl-N-nitrosourea induced carcinomas of the forestomach and local s.c. sarcomas respectively in BD-rats. This confirms a local carcinogenic effect of the compound. In prenatal experiments in BD-rats no carcinogenic effect of BzNH could be found.
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D012509:Sarcoma / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009607:Nitrosourea Compounds
Carcinogene Wirkung von N-Benzyl-N-Nitrosoharnstoff (BzNH) an BD-Ratten.