[Rates of endogenous noradrenaline release in rat brain, heart and intestines: comparison of results obtained after biosynthesis inhibition and 3H-tyrosine labeling].
After labelling of noradrenaline stores with tyrosine 3H, the rate constant of NA efflux was calculated from the change of the NA-3H and TY-3H specific activities. The biological half-life of NA was 2,2 h in the brain, 24 h in the heart and 3,3 h in the intestine. These values were similar to those obtained after inhibition of NA synthesis by alpha-methylparatyrosine.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D014316:Tritium; D014443:Tyrosine / Q000378:metabolism
D008781:Methyltyrosines; D014316:Tritium; D014443:Tyrosine; D009638:Norepinephrine
Vitesses de libération de la noradrénaline endogène dans le cerveau, le coeur et l'intestin du rat: comparaison des résultats obtenus aprés ingibition de la biosynthèse et marquage par la tyrosine 3H