[Consequences of the chronic administration of phenformine on the blood thiamine level in the dog].
The chronic oral administration of phenformin (20 mg/kg daily during 8 days) to the normal concious dog provokes a decrease in the fasting thiamine levels of plasma and erythrocytes. During intragastric loading tests with thiamine hydrochloride (30 mg/kg), carried out during the chronic treatment with the biguanide, the curve of plasma hyperthiaminemia is increased. The authors suggest an explanation for these apparently contradictory results.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D004912:Erythrocytes / Q000032:analysis; D007773:Lactates / Q000097:blood; D010629:Phenformin / Q000008:administration & dosage / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D013831:Thiamine / Q000097:blood*
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D010629:Phenformin; D013831:Thiamine
Conséquences de l'administration chronique de phenformine sur les taux de thiamine dans le sang chez le chien