Studies on function of lymphocytes in NZB X NZW F 1 hybrid mice; autoantibody-producing cells and cytotoxicity of lymphocytes.
Several experiments were performed using B/W mice, experimental model of human systemic lupus crythematosus, with a view to explore the pathogenesis of autoimmune diseases. As a result of the Investigation by the immunocyte adherence method, autoantibody-producing cells were demonstrated at a ration of 1 to 4% in the spleen, thymus and lymph nodes of B/W mice, but nearly absent in the bone marrow. B/W mouse lymphocytes showed the cytotoxic activity to allgeneic target cells (L cells), but ANA positive sera from B/W mice also had a remarkable cytotoxic activity in the presence of the complement of a high concentration. It was also disclosed that there are Ig+ and theta-lymphocytes in the B/W mouse thymus at a nearly equal percentage, and the possible identity of the two was suggested.
D000921:Antibody-Producing Cells; D001323:Autoantibodies; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D007739:L Cells; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D001323:Autoantibodies; D003165:Complement System Proteins