Effects of phenobarbitone, cinnarizine, and zoxazolamine on the development of right ventricular hypertrophy and hypertensive pulmonary vascular disease in rats treated with monocrotaline.
The results of this experiment suggest that the addition of zoxazolamine to the diet may prolong the survival and reduce the incidence of right ventricular hypertrophy and hypertensive pulmonary vascular disease in male rats given a single subcutaneous injection of monocrotaline. Phenobarbitone and cinnarizine were ineffective.
D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000517:prevention & control*; D002936:Cinnarizine / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011763:Pyrrolizidine Alkaloids / Q000009:adverse effects*; D051381:Rats; D015049:Zoxazolamine / Q000494:pharmacology*
D010879:Piperazines; D011763:Pyrrolizidine Alkaloids; D002936:Cinnarizine; D015049:Zoxazolamine; D010634:Phenobarbital