A simple and practical method for isolation of an early plasmin degradation product of human fibrinogen.
One of the earliest plasmin degradation products of human fibrinogen, so-called fragment A, was isolated by a simple method. This peptide has a molecular weight of approximately 22,500, migrating electrophoretically at beta-area, and its amino acid composition shows a very high content of glycine, serine, threonine and proline, and a markedly low content of hydrophobic amino acids. This fragment does not react against anti-fibrinogen; however, the anti-serum of this fragment reacts strongly with fibrinogen.
D004591:Electrophoresis, Polyacrylamide Gel; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005341:Fibrinolysin; D005998:Glycine; D006801:Humans; D005779:Immunodiffusion; D008722:Methods; D008970:Molecular Weight; D011392:Proline; D012694:Serine; D013912:Threonine
D005338:Fibrin Fibrinogen Degradation Products; D013912:Threonine; D012694:Serine; D011392:Proline; D005341:Fibrinolysin; D005998:Glycine