Circulating antigen-antibody complexes in patients with immune complex disorders and following kidney transplantation.
The presence of circulating soluble complexes antigen-antibody was investigated by means of our simple test (1) in small serum samples of patients before and after kidney transplantation. We found a higher incidence of positive test results in patients with an original diagnosis of chronic glomeruleonephritis following transplantation in 37.1%, than before transplantation (in 28.5%). In both instances, however circulating immune complexes were less frequent than in a previously studied group of patients with chronic glomerulonephritis (66.6%), or particularly in glomerulonephritis cases with the characteristics of disease activity (100%) positivity. In patients suffering from pyelonephritis, a diseases not due to immune complexes, 18% of sera were positive. After transplantation the number of positive sera rose to 35.5% in 13 patients. The reasons for this finding are being analysed.
D000936:Antigen-Antibody Complex; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D016030:Kidney Transplantation; D011704:Pyelonephritis / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous
D000936:Antigen-Antibody Complex