[Implantation of a bio-artificial insulin distributor in dogs, using islets of Langerhans from different animal species].
In the diabetic dog, the implantation of a bioartificial insulin distributor (Biard) producted a temporary normoglycemia, using islets of Langerhans isolated from dog pancreas and cultured on the outer surface of the hollow fibers (XM 50). In a diabetic dog receiving the Biard using porcine isolated islets, the hyperglycemia was partially corrected during two days. In a diabetic dog due to implantation of human isolated islets the slight rise of insulin and human C-peptide is not accompanied by significant decrease in hyperglycemia. However, in another diabetic dog the Biard implantation of human islets provoked a significant increase of insulin and human C-peptide in the blood, with partial normalisation of hyperglycemia during two days.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004285:Dogs; D006801:Humans; D007515:Islets of Langerhans / Q000502:physiology; D016381:Islets of Langerhans Transplantation; D013045:Species Specificity; D013552:Swine; D014183:Transplantation, Heterologous
Implantation du distributeur bio-artificiel d'insuline chez le chien utilisant des îlots de Langherans d'espèces animales différentes.