[Excretion of catecholamines and tryptophan derivatives in schizophrenia].
In order to study the correlations between the metabolism of biogenic monoamines and the type of development) of schizophrenia, the morning urine excretion of 30 patients (15 with continuous progressive schizophrenia and 15 with shift-like forms of development) was examined. The author studied the percentage of distribution of data, dophamine, noradrenaline and adrenaline and the correlation between these ingredients in the catecholamine system, as well as the distribution of tryptophane. It was established that in schizophrenia there is a noradrenaline deficit and a drop in the activity of tryptophane metabolism towards the serotonin way. Besides, in patients with continuous progressive forms of the disease there was a simultaneous drop in the intensity of dophamine synthesis from dopha, while in patients with shift-like schizophrenia-an excess of dophamine, conditioned probably not only by an inhibition of phamine-B-oxydase, but by an increase of dophadecarboxylase activity.
D000293:Adolescent; D000328:Adult; D001679:Biogenic Amines / Q000652:urine*; D004295:Dihydroxyphenylalanine / Q000652:urine; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000652:urine; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000031:analogs & derivatives / Q000652:urine; D009638:Norepinephrine / Q000652:urine; D012559:Schizophrenia / Q000652:urine*; D014363:Tryptamines / Q000652:urine
D001679:Biogenic Amines; D014363:Tryptamines; D009536:Niacinamide; D006897:Hydroxyindoleacetic Acid; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Ekskretsiia katekholaminov i proizvodnykh triptofana pri shizofrenii