An unusual side effect on the skin under high dose D-penicillamin treatment.
An unusual side effect on the skin after one year's high dosage (3,0 g/die) of D-Penicillamin-treatment is reported. The skin showed double-pin-sized vesicles and laceration after minor injuries. After reduction of the dosage to 1,8 g/die and bathing the hands three times/day for 2 minutes in 1% Tannin solution the skin lesions and wounds healed eventually.
D000328:Adult; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000188:drug therapy; D012867:Skin / Q000187:drug effects; D013634:Tannins / Q000627:therapeutic use
D013634:Tannins; D010396:Penicillamine