Influence of cerebrolysin(r) on the resistance of rats to anoxia.
Single injections of Cerebrolysin(R) did not affect the resistance of rats to anoxia, irrespective of age. Cerebrolysin(R) significantly raised the resistance of the young of females injected ten times i.p. with the same dose during pregnancy. The repeated (5-fold) administration of Cerebrolysin(R) significantly raised the resistance of 35-day-old rats to anoxia and, in high concentrations, it also increased the resistance of adult rats. The effect of Cerebrolysin(R) is correlated to the proportion of amino acids, aligopeptides and the nucleotides they contain. The mere administration of a mixture of amino acids or of some other hydrolysate (Testolysin) was ineffective in this respect.
D000596:Amino Acids / Q000627:therapeutic use*; D000818:Animals; D001921:Brain; D005260:Female; D000860:Hypoxia / Q000517:prevention & control*; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013737:Testis; D014020:Tissue Extracts / Q000008:administration & dosage / Q000627:therapeutic use
D000596:Amino Acids; D014020:Tissue Extracts