[Effects of beta-phenylethylamine derivatives on the central nervous system. (5) The effect of intracerebral administration of tyramine on head twitching in mice pre-treated with isocarboxazid].
Effects of drugs on head-twitches induced by tyramine (Ty) in isocarboxazide (Iso) pretreated mice were studied and the following results obtained: 1) In beta-phenylethylamine derivatives, p-hydroxyamphetamine in non-treated and Iso-pretreated mice and Ty in Iso-pretreated mice produced head-twitches. 2) Injection of 5-HTP (i.c. and i.p.) into mice induced head-twitches. 3) Although head-twitches were not induced by a low dose of 5-HTP (20 mg/kg, i.p.), in Iso pretreated mice, the number of headtwitches increased markedly in the Iso-Ty treated group when Ty was injected i.c. in Iso+5-HTP (20 mg/kg) pretreated mice. 4) When Iso-Ty was injected into alpha-methyl-p-tyrosine pretreated mice, the number of head-twitches increased markedly compared with Iso-Ty treated group. 5) When Iso-Ty was injected into mice sustained with p-chlorophenylalanine, the number of head-twitches decreased markedly compared with the Iso-Ty treated group. 6) The number of head-twitches decreased markedly when Iso-Ty was injected into dimetotiazine pretreated mice, however the administration of Iso-Ty in haloperidol pretreated mice had no influence on head-twitches. 7) It is concluded that serotonin is the acting mediator in the head-twitch response.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006257:Head; D007520:Isocarboxazid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects*; D010640:Phenothiazines / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology; D014439:Tyramine / Q000008:administration & dosage / Q000494:pharmacology*; D014443:Tyrosine / Q000494:pharmacology
D000662:Amphetamines; D010640:Phenothiazines; D007520:Isocarboxazid; D014443:Tyrosine; D010649:Phenylalanine; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D010134:Fenclonine; D014439:Tyramine