Fetal antigens associated with adenovirus 12 mouse tumors.
The fetal antigen(s) of C3H/BfB/Ki mouse tumor cells induced by adenovirus type 12 was examined by transplantation resistance, local adoptive transfer and in vitro cell-mediated microcytotoxicity tests. Mice immunized with 8 to 9-day gestation fetal cells showed weak resistance to the challenge of small numbers of tumor cells, but immunization with 13 to 14-day gestation fetal cells did not confer transplantation immunity. Local adoptive transfer of multiparous pregnant mouse spleen cells mixed with tumor cells showed a small inhibition of tumor growth in all cases, but primiparous pregnant mouse spleen cells showed a protective effect in only one of three samples. In the cell-mediated microcytotoxicity test, spleen cells taken from the fetal tissue-immunized or multiparous pregnant mice showed a cytotoxic effect to MT-2 cells (adenovirus type 12 tumor cell line) and mouse fetal cells, but not to newborn mouse kidney cells. These results strongly suggest the presence of phase-specific tumor-associated fetal antigen(s) which can evoke transplantation immunity.
D000260:Adenoviruses, Human; D000818:Animals; D000951:Antigens, Neoplasm; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005333:Fetus / Q000276:immunology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology*; D011247:Pregnancy; D013154:Spleen / Q000276:immunology; D014181:Transplantation Immunology
D000951:Antigens, Neoplasm