Effect of X-537A- on the phosphorylated protein in sarcoplasmic reticulum vesicles.
The effect of the antibiotic X537A on the phosphorylated ATPase (E approximately P) was investigated. The results show that X-537A depresses the level of E approximately P which is dependent on the Ca2+ gradient, while the Ca2+-independent E approximately P is not affected.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004533:Egtazic Acid / Q000494:pharmacology; D007832:Lasalocid / Q000494:pharmacology*; D009132:Muscles / Q000378:metabolism; D010750:Phosphoproteins / Q000096:biosynthesis*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010750:Phosphoproteins; D004533:Egtazic Acid; D000244:Adenosine Diphosphate; D000251:Adenosine Triphosphatases; D002118:Calcium; D007832:Lasalocid