title: [Vitamin A, membranes and the differentiation of cells].
abstract: The paper deals with analysis of biochemical, morphological and physiological changes in vitamin A-deficiency. On the basis of this analysis a conclusion is drawn that vitamin A is first of all the factor of differentiation. The intercellular zone is considered to be the most probable sphere of its primary effect. Deficiency in vitamin A causes a change in a concentration and ratio of cations and glycosaminglycans in this zone, that results in disturbance of the intercellular interactions. Other changes--in the DNA-RNA system, protein biosynthesis, sulphate, energy and other metabolisms--might be secondary. By the character of action vitamin A may be closed to hormones than to water-soluble vitamins.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000378:metabolism; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009929:Organ Size; D012313:RNA / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000502:physiology; D014801:Vitamin A / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D014802:Vitamin A Deficiency / Q000378:metabolism / Q000503:physiopathology
chemical_list: D006025:Glycosaminoglycans; D012177:Retinol-Binding Proteins; D014801:Vitamin A; D012313:RNA; D004247:DNA; D012343:RNA, Transfer
vernacular_title: Vitamin A, membrany i differentsiatsiia kletok