Protective effect of drugs on histamine-induced asthma.
Controlled standardised histamine inhalation tests were carried out in 21 asthmatics to determine the degree of non-specific bronchial hyperreactivity with and without prior treatment with several anti-asthmatic drugs. A significant protective effect was produced by inhaled salbutamol, 200 microgram, ingested salbutamol, 4 mg, inhaled Sch1000, 40 microgram inhaled atropine sulphate, 290 microgram, and ingested choline theophylinate (200 or 400 mg) producing serum theophylline levels over 10 mg/l. Inhaled salbutamol was consistently the most effective and was significantly better than the other drugs. The protective effect between the other four was not significantly different. Drug side-effects occurred only with the ingested drugs. No significant protection was detected after ingested choline theophyllinate producing serum theophylline levels of less than 10 mg/l, inhaled sodium cromoglycate, 20 mg given once or six-hourly for one week, or ingested ascorbic acid, 1 gram.
D000420:Albuterol / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001285:Atropine / Q000627:therapeutic use; D002794:Choline / Q000627:therapeutic use; D004205:Cromolyn Sodium / Q000627:therapeutic use; D005260:Female; D006632:Histamine; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D008297:Male
D001285:Atropine; D006632:Histamine; D009241:Ipratropium; D002794:Choline; D001205:Ascorbic Acid; D004205:Cromolyn Sodium; D000420:Albuterol