Correlation between rises of gonadotrophins and rises of sex steroids during clomiphene test in men.
Serum FSH, LH and testosterone and urinary excretion of androsterone, aetiocholanolone, dehydroepiandrosterone and total oestrogens were measured in normal and oligospermic men before and after clomiphene stimulation. Responses in all parameters were highly variably from one individual to another and this great variation formed the basis for investigating the correlations between responses. There was no correlation between increase of FSH and LH or increase of LH and steroids. Also there was no correlation between rises of FSH and rises of androgens. But a significant correlation existed between rises of FSH and rises of oestrogens. This confirms that one action of FSH is to stimulate production of testicular oestrogens which presumably takes place in the Sertoli cells.
D000293:Adolescent; D000328:Adult; D000738:Androsterone / Q000652:urine; D002996:Clomiphene; D003687:Dehydroepiandrosterone / Q000652:urine; D005043:Etiocholanolone / Q000652:urine; D005640:Follicle Stimulating Hormone / Q000097:blood*; D012739:Gonadal Steroid Hormones / Q000652:urine*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009845:Oligospermia / Q000378:metabolism / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D002996:Clomiphene; D013739:Testosterone; D003687:Dehydroepiandrosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005043:Etiocholanolone; D000738:Androsterone