[Pharmacotherapy of hypertension and its significance for the function of the salivary glands (author's transl)].
The secretion mechanism of the large salivary glands at the level of the acinus cells is presented to explain the side effects "dryness of the mouth and initial parotid pain on chewing". The importance of adrenergic alpha- and beta-receptors and a cholinergic receptor in the acinus cell membrane is discussed in connection with the action of antihypertensives on the autonomic nervous system. Experiments on rat salivary glands after treatment with clonidine, guanoxan and propranolol serve as a basis for this.
D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D003000:Clonidine / Q000627:therapeutic use; D006146:Guanidines / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008409:Mastication / Q000187:drug effects; D010306:Parotid Gland / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D012469:Salivary Glands / Q000187:drug effects* / Q000502:physiology; D013566:Sympathomimetics / Q000627:therapeutic use; D014987:Xerostomia / Q000139:chemically induced
D000959:Antihypertensive Agents; D006146:Guanidines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D013566:Sympathomimetics; D011433:Propranolol; D003000:Clonidine
Pharmakotherapie der Hypertonie und ihre Bedeutung für die Funktion der Kopfspeicheldrüsen