[Demonstration of cellular antibodies against streptococcal antigens in children (author's transl)].
In a group of 48 children the following streptococcal antigens were tested by means of the lymphocyte transformation test: group A streptococcal M1- and M19-protein, mucopeptide, polysaccharides from group A and group C streptococci, erythrogenic toxins and streptokinase. Specific transformations were obtained only by M-proteins. Erythrogenic toxines induced an unspecific stimulation comparable to the mitogenic activity of phytohaemagglutinins. No reactions could be found with streptococcal mucopeptide, the group-specific carbohydrates of groups A and C-streptococci and streptokinase, resp. A significant difference was seen in the group of young children (mean age 5 years) between the specific transformability by M1-protein (a common type) and M19-protein (a rare type). No difference was seen with both M-proteins in the group of older children (mean age 11 years). In both groups of children no differences exist in the number of positive cutaneous reactions after injection of M1- and M19-proteins, but the intensity of reactions (diameters of erythema) were more pronounced with the M-protein of the common type 1.
D000367:Age Factors; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001426:Bacterial Proteins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008213:Lymphocyte Activation; D009088:Mucoproteins / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012882:Skin Tests; D013291:Streptococcus / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*; D013300:Streptokinase / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D009088:Mucoproteins; D011135:Polysaccharides, Bacterial; D013300:Streptokinase
Nachweis zellulärer Antikörper gegen Streptokokkenantigene bei Kindern