Experimental data asserting the immune morpho-pathogenic component of chronic inflammatory processes.
The action of several agents (Mycobacteria, Aspergillus, silicium dioxide, beryllium salts, phospholipids, incomplete and complete Freund adjuvant, a.o.) was analysed on the rabbit lung. The developmental analysis of experimental processes induced by intravenous or intratracheal injections showed that after a first inflammatory phase an immune one was formed, demonstrated by epithelioid cells, lymphocytes and plasma cells. In some cases, several waves of immune cells could be demonstrated in the evolution of the morphopathologic picture, even in the phases when the initial antigens were resorbed; these restructurations could be induced by endoantigens produced by tissular changes, by cell differentiations, by common or immune vascular lesions. The intrication of an immune sequence in the stereotyped development determined the prolongation of the process duration, the complications of relationships between sequences, the process maintenance. The experimental analysis was able to decode this complicated evolution.
D000818:Animals; D000941:Antigens / Q000032:analysis; D001228:Aspergillosis / Q000150:complications; D001424:Bacterial Infections / Q000150:complications; D001608:Beryllium; D002908:Chronic Disease; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology*; D010743:Phospholipids; D011817:Rabbits; D051381:Rats; D012825:Silicon
D000941:Antigens; D010743:Phospholipids; D005620:Freund's Adjuvant; D001608:Beryllium; D012825:Silicon