Unilateral nephrectomy: effect on survival in NZB/NZW mice.
Male F1 New Zealand Black X New Zealand White mice, which spontaneously develop immune complex renal disease, underwent unilateral nephrectomy at 3 months of age and were compared with sham-operated controls. At 12 months of age only 24% of mice with a single kidney were alive, while 85% of sham-operated controls survived to the same age. Unilaterally nephrectomized mice had more severe renal histologic changes, as shown by light and immunofluorescence microscopy.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex; D001806:Blood Urea Nitrogen; D007105:Immune Complex Diseases / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D009392:Nephrectomy
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex