Septal rage: mitigation by pre-surgical treatment with p-chlorophenylalamine.
Destruction of the septum leads to a well known hyperirritability syndrome. However, the intensity of this syndrome is modifiable by certain presurgical treatments. Injections, prior to surgery of para-chlorophenylalanine (PCPA) for two days or insulin for five days has no effect on septal rage. However, injections of PCPA five days prior to surgery leads to a marked reduction in septal hyperirritability.
D000786:Anger / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D010134:Fenclonine / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000494:pharmacology; D008297:Male; D011292:Premedication; D011889:Rage / Q000187:drug effects*; D051381:Rats; D012688:Septum Pellucidum / Q000502:physiology*; D013577:Syndrome; D013997:Time Factors
D007328:Insulin; D010134:Fenclonine