The response of C3H mice to streptozotocin. I. Thymic depression and leukocyte toxicity.
Streptozotocin, an antibiotic with reported antileukemic activity, was administered to C3H mice to evaluate the response of peripheral blood leukocytes and thymic lymphocytes. The hematologic effects of a single diabetogenic dose of streptozotocin include an absolute neutropenia and a depression of tritiated thymidine incorporation into thymic lymphocytes.
D000818:Animals; D003864:Depression, Chemical; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013311:Streptozocin / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism*
D013311:Streptozocin; D013936:Thymidine