Effect of (+)-catechin on renal and intestinal transport.
The ability of dog renal cortex slices to accumulate beta-methyl-glucoside or glycine is enhanced by the flavonoid (+)-catechin at a concentration of 3.5 mM. This stimulatory effect is apparently due to a decreased rate of efflux of either substrate. On the other hand, the uptake of p-amino-hippuric acid and N1-methyl-nicotinamide is inhibited by (+)-catechin. The drug at the same concentration is without action on amino-acid transport by guinea-pig intestine in vitro.
D000618:Aminohippuric Acids / Q000378:metabolism; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D004285:Dogs; D005998:Glycine / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008757:Methylglucosides / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism
D000618:Aminohippuric Acids; D001578:Benzopyrans; D008757:Methylglucosides; D009536:Niacinamide; D010649:Phenylalanine; D002392:Catechin; D005998:Glycine