Effects of tetrahydropapaveroline on dopamine and 5-hydroxytryptamine metabolism in rat brain in vivo.
HVA and 5-HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L-dopa-induced HVA increase in the rat brain as well as the PCPA-induced 5-HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L-dopa long-term therapy in parkinsonism.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D007546:Isoquinolines / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D010208:Papaverine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D007546:Isoquinolines; D012701:Serotonin; D007980:Levodopa; D010208:Papaverine; D010134:Fenclonine; D004298:Dopamine; D006719:Homovanillic Acid