[Experimental value of the biliary excretion of the conjugated form of SBP by the in vivo liver and by the isolated and perfused liver].
We first studied the uptake and excretion of the dye BSP by the isolated and perfused rat liver and by the rat liver in vivo. We then studied BSP-glutathion conjugation with these same methods. We found that benziodarone which induces a marked decrease of conjugation is able to inhibit in vitro the combination BSP-glutathion.
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D001646:Bile / Q000032:analysis*; D001667:Binding, Competitive; D001711:Biotransformation; D002251:Carbon Tetrachloride / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism*
D001572:Benzofurans; D013448:Sulfobromophthalein; D002251:Carbon Tetrachloride; D005982:Glutathione Transferase; D005978:Glutathione
Intérêt expérimental de l'élimination biliaire de la forme conjuguée de la BSP par le foie, in vivo et par le foie isolé et perfusé