Increased plasma prolactin levels induced in rats by d-fenfluramine: relation to central serotonergic stimulation.
d-Fenfluramine (7.5 and 10 mg/kg i.p.) and quipazine (10 and 20 mg/kg i.p.) increased plasma prolactin levels in male rats. Metergoline (3 mg/kg p.o.) or p-chlorophenylalanine (100 mg/kg X 3, orally) pretreatment markedly blocked the prolactin-releasing effect of both d-fenfluramine and quipazine. This result suggests that the effect of these drugs on prolactin secretion could be mediated through a serotonergic mechanism. Brain serotonin may thus exert a stimulatory role on prolactin secretion in rats.
D000818:Animals; D010134:Fenclonine / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D013268:Stimulation, Chemical
D008711:Metergoline; D005277:Fenfluramine; D012701:Serotonin; D011814:Quipazine; D011388:Prolactin; D010134:Fenclonine