Lymphocytotoxins and mixed leucocyte culture blocking factor activity in the plasma of uraemic patients undergoing haemodialysis.
Mixed leucocyte culture blocking factor activity (MLC-BFA) in the plasma of haemodialysis patients appears as a result of recent blood transfusions and is concentrated in IgG fractions of the blocking serum. Four patients neither developed lymphocytotoxins nor MLC-BFA in spite of having received multiple blood transfusions. Such 'unresponsive' recipients had an excellent clinical course upon receiving an allograft.
D001803:Blood Transfusion; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007962:Leukocytes / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008233:Lymphotoxin-alpha / Q000097:blood*; D008297:Male; D006435:Renal Dialysis; D014511:Uremia / Q000276:immunology* / Q000628:therapy
D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008233:Lymphotoxin-alpha