title: New and uncommon indole- and imidazole-alkylamines in skins of amphibians from Australia and Papua New Guinea.
abstract: Extracts of the skin of some amphibians from Australia and Papua New Guinea contained, in addition to the usual 5-hydroxyindolealkylamines and histamine: a. two new, hitherto unknown indolealkylamines, i.e. O-sulphate of bufotenidine and 2-(3-indolyl) ethyltrimethylammonium, a quaternary ammonium base of tryptamine. The rare O-sulphate of bufotenine was also present, the occurrence of which had previously been demonstrated only in the skin of some South American toads; b. a series of uncommon imidazolealkylamines, such as N'-acetylhistamine, N'-methylhistamine, N',N'-dimethylhistamine, spinaceamine and 6-methylspinaceamine. It appears evident that amphibian skin continues to be an exceptionally rich source of aromatic amines.
mesh_terms: D000588:Amines / Q000032:analysis / Q000378:metabolism; D000663:Amphibians / Q000378:metabolism; D000818:Animals; D001315:Australia; D002027:Bufotenin / Q000032:analysis; D007093:Imidazoles / Q000032:analysis*; D007211:Indoles / Q000032:analysis* / Q000378:metabolism; D009512:New Guinea; D012867:Skin / Q000032:analysis*
chemical_list: D000588:Amines; D007093:Imidazoles; D007211:Indoles; D002027:Bufotenin