[Electron-microscopic histochemistry of phosphohydrolases in the normal mucosa and in the cells of human gastric adenocarcinoma].
Electron-histochemical study of phosphohydrolases (ATPase, acid and alkaline phosphatases) in cells of the normal gastric mucosa, duodenal mucosa and gastric adenocarcinoma of man was carried out. In cancer cells retaining to a certain extent the ultrastructural features of the chief cells, parietal cells of enterocytes, the distribution of the product of reaction for ATPase and acid phosphatase in nucleoli, endoplasmic reticulum membranes, intracellular cannaliculi, plasmalemma, mitochondria, the distribution of the product of reaction for ATPase and acid phosphatase in nucleoli, tural features of enterocytes, no activity of alkaline phosphatase could be demonstrated in membranes of the villi of the striated border. Alongside with the retention or disappearance of electron-histochemical features, some of them may be enhanced. Thus, the activity of acid phosphatase was increased in lysosomes of cancer cells (of the type of chief cells). So, in cancer cells of adenocarcinoma the structure-functional rearrangement going in different directions is observed in addition to the process of simplification and unification.
D000135:Acid Phosphatase / Q000032:analysis*; D000230:Adenocarcinoma / Q000473:pathology*; D000251:Adenosine Triphosphatases / Q000032:analysis*; D000469:Alkaline Phosphatase / Q000032:analysis*; D003593:Cytoplasm / Q000201:enzymology; D005753:Gastric Mucosa / Q000166:cytology*; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D013274:Stomach Neoplasms / Q000473:pathology*
D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases
Elektronnaia gistokhimiia fosfogidrolaz v normal'noĭ slizistoĭ obolochke i v kletkakh adenokartsinomy zheludka cheloveka.