[Pharmacological influence on central serotonergic mechanisms in man and its consequences on sleep (author's transl)].
Central serotonergic mechanisms were investigated in three experiments: 1. Chronic administration (four weeks) of L-5-hydroxytryptophan (L-5 HTP 600 mg/day) plus decarboxylase inhibitor (Ro 4-4602) reduces slow-wave sleep (stages 3 + 4 = SWS) without influencing other sleep parameters. 2. Clozapine reduces SWS, increases paradoxical sleep (REM) and dissociates sleep mechanisms so that increased REM in NREM stage 1 occurs. Central serotonin levels seem to remain unaffected. 3. Parachlormethylamphetamine, a serotonin synthesis inhibitor, normalises irregular sleep and narcoleptic and cataleptic attacks of narcoleptic syndrome as well. 4. Central serotonergic mechanisms are described as having a boundary-setting function.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000328:Adult; D001545:Benserazide / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D003024:Clozapine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism*; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
D012701:Serotonin; D008694:Methamphetamine; D001545:Benserazide; D006916:5-Hydroxytryptophan; D003024:Clozapine
Pharmakologische Beeinflussung zentraler serotonerger Mechanismen am Menschen und Auswirkungen auf den Schlaf