Degree of sulfation in mucopolysaccharide sulfates in normal and stone-forming urines.
Mucopolysaccharides were extracted from both normal and stone-forming urines, and those from the stone-forming samples showed a higher degree of sulfation than those from normal urines, as determined by sulfate analysis and electrophoretic measurement. The sulfated mucopolysaccharides from stone-forming urines formed insoluble calcium salts, whereas those from normal urines generally remained soluble in the presence of calcium ion. Rachitic rat cartilage was found to have more highly sulfated mucopolysaccharides than normal rat cartilage. Highly sulfated mucopolysaccharides appear to be a significant factor in calcium stone formations.
D000818:Animals; D002417:Cattle; D002809:Chondroitin Sulfates / Q000652:urine; D004586:Electrophoresis; D006025:Glycosaminoglycans / Q000652:urine*; D006497:Heparan Sulfate / Q000652:urine; D051381:Rats; D013431:Sulfates / Q000652:urine*; D014545:Urinary Calculi / Q000652:urine*
D002809:Chondroitin Sulfates; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D013431:Sulfates