The interaction of organic cations with the mitochondrial membrane.
Weak and strong organic bases behave in an opposite manner in respect to several mitochondrial functions. The former induce a catalytic exchange with K+ in valinomycon-treated, respiratory-inhibited mitochondria, and act as uncouplers in respiring mitochondria. The latter induce a stoicheometric exchange with K+ and are actively taken up by respiring mitochondria.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000588:Amines / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D004396:Coloring Agents / Q000494:pharmacology*; D004140:Dinitrophenols / Q000494:pharmacology; D004996:Ethidium / Q000494:pharmacology; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011796:Quinacrine / Q000494:pharmacology; D051381:Rats; D012402:Rotenone / Q000494:pharmacology; D013775:Tetraphenylborate / Q000494:pharmacology; D014634:Valinomycin / Q000494:pharmacology
D000588:Amines; D000779:Anesthetics, Local; D004396:Coloring Agents; D004140:Dinitrophenols; D000644:Quaternary Ammonium Compounds; D012402:Rotenone; D014634:Valinomycin; D013775:Tetraphenylborate; D000251:Adenosine Triphosphatases; D004996:Ethidium; D011796:Quinacrine; D011188:Potassium