The effect of experimental anaemia on the levels of glutathione and glycolytic enzymes of the erythrocytes of normal and glutathione-deficient Merino sheep.
The effects of experimental anaemia on the levels of reduced glutathione (GSH) and the activity of glycolytic enzymes in the erythrocytes of normal and GSH-deficient Merino sheep were investigated. There was a rise in red cell GSH levels in both groups of sheep; the magnitude of this response was, however, quite different. When expressed as a percentage of the initial value, the rise in GSH level was 18% in normal and 263% in GSH-deficient animals. There was also an increase in the activities of various enzymes following phlebotomy but this increase was similar in the two groups of sheep.
D000740:Anemia / Q000097:blood / Q000201:enzymology*; D000818:Animals; D004912:Erythrocytes / Q000201:enzymology* / Q000378:metabolism; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood / Q000172:deficiency*; D005980:Glutathione Reductase / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006593:Hexokinase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010732:Phosphofructokinase-1 / Q000097:blood; D010734:Phosphogluconate Dehydrogenase / Q000097:blood; D010735:Phosphoglycerate Kinase / Q000097:blood; D011770:Pyruvate Kinase / Q000097:blood; D012756:Sheep
D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase; D010735:Phosphoglycerate Kinase; D005634:Fructose-Bisphosphate Aldolase; D005956:Glucose-6-Phosphate Isomerase; D005978:Glutathione