Metabolism of [4C]crufomate (4-t-butyl-2-chlorophenyl methyl methylphosphoramidate) by the sheep.
Twenty-five metabolites were isolated from the urine, feces or plasma of sheep given single oral doses of [14C]crufomate (4-t-butyl-2-chlorophenyl methyl methylphosphoramidate). These metabolites resulted from one or more of the following transformations: oxidatin of a methyl group in the t-butyl moiety to yield either an alcohol or a carboxylic acid; hydrolysis of the phosphate and phosphate and phosphoramidate bonds; oxidatin of the N-methyl group to yield N-formyl phosphoramidates; methylation of the N-formyl group to yield N-methyl-N-formyl phosphoramidates; oxidative N-demethylation; conjugation with glucuronic acid. No ring-hydroxylation of dechlorination was observed, and no crufonate was isolated from the urine, feces or plasma.
D000818:Animals; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D002850:Chromatography, Gel; D005243:Feces / Q000032:analysis; D007306:Insecticides / Q000378:metabolism*; D013058:Mass Spectrometry; D009943:Organophosphorus Compounds / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012588:Scintillation Counting; D012756:Sheep
D002250:Carbon Radioisotopes; D007306:Insecticides; D009943:Organophosphorus Compounds