Effect of fominoben-HCl on circulation, pulmonary gas exchange and acid-base balance at rest and during exercise.
The effect of 3'-chloro-2'-[N-methyl-N[(morpholino-carbonyl)methyl]aminomethyl]benzanilide-hydrochloride (forminoben-HCl, Noleptan) on pulse rates and blood pressures, ventilation and gas exchange, and acid base balance was studied in eleven patients aged 31 to 72 years at rest and during a standardised excercise. Mean systolic and diastolic blood pressures decreased at rest before and 10 min after work as well as during work. Mean alveolar ventilation was reduced by 9% at rest and was unchanged during work. No changes occurred in mean alveolar-arterial oxygen differences or in mean anatomical right-to-left shunt. In a few individual patients with grossly impaired intrapulmonary gas exchange, however, an improvement with regard to alveolar ventilation in relation to oxygen uptake and the alveolar-arterial oxygen tension difference could be demonstrated.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*
D009025:Morpholines; D002245:Carbon Dioxide; D010100:Oxygen