Myeloid regeneration after whole body irradiation, autologous bone marrow transplantation, and treatment with an anabolic steroid.
Stumptail monkeys (Macaca speciosa) received lethal whole body radiation. Autologous bone marrow injection resulted in survival of the majority of the animals. Treatment with Deca-Durabolin, an anabolic steroid, caused more rapid recovery of colony-forming cell numbers in the bone marrow than in control animals. Both the Deca-Durabolin-treated and control groups were given autologous bone marrow transplantation. Anabolic steroid effect on transplanted bone marrow colonyforming cells may explain the increased rate of leukopoietic regeneration in anabolic steroid-treated animals as compared to controls.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002999:Clone Cells; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes; D007959:Lymphocyte Culture Test, Mixed; D008251:Macaca; D008297:Male; D009277:Nandrolone / Q000494:pharmacology*; D011829:Radiation Dosage; D011830:Radiation Effects; D012038:Regeneration; D014182:Transplantation, Autologous
D009277:Nandrolone