Precocity of pulmonary vascular obstruction of Down's syndrome.
Studying the pulmonary vascular resistance in children with ventricular septal and endocardial cushion defects, the authors found a statistically significant earlier and more severe reaction in children with Down's syndrome as compared to normals. Cardiac investigations with regard to surgical intervention should be made early in life, if the parents wish their child with Down's syndrome to undergo surgery.
D000293:Adolescent; D001011:Aorta / Q000503:physiopathology; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000503:physiopathology; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications* / Q000175:diagnosis; D004562:Electrocardiography; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D006345:Heart Septal Defects, Ventricular / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011379:Prognosis; D011651:Pulmonary Artery / Q000503:physiopathology*; D014655:Vascular Resistance