[Late perturbations of the central nervous system compatible with life. 5. Study of learning aptitude of the offspring after administration of anticerebroside serum to pregnant female and newborn rats].
Rabbits are injected with cerebrosids, cholesterol and albumen. Their serum, titrated for anticerebrosids antibodies, was injected into female rats on the 18th, 19th and 20th days of gestation and into the offspring aged 5, 9 and 14 days. The learning ability of the little rats was explored at the age of 1-1/2, 3, 4-1/2 and 6 months. Only the offspring of non-treated mothers and treated themselves present an important alteration of their learning ability, particularly if the injection is on the 5th post-natal day. These results are discussed.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000008:administration & dosage; D002554:Cerebrosides / Q000276:immunology / Q000502:physiology*; D003214:Conditioning, Classical; D005260:Female; D007858:Learning; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011817:Rabbits; D051381:Rats
D000906:Antibodies; D002554:Cerebrosides
Perturbations tardives du système nerveux central compatibles avec la vie. V. Etude des capacités d'apprentissage de la progéniture après administration de sérums anticérébrosides à la ratte gestante et aux nouveau-nés