title: Effects of physical training on end-diastolic volume and myocardial performance of isolated rat hearts.
abstract: We studied the performance of ventricular muscle and cardiac function of hearts from rats conditioned by swimming (CH) and from sedentary rats (SH) in an isolated working heart apparatus modified to measure end-diastolic volume by dye dilution. Instantaneous aortic flow, left ventricular (LV) pressure and oxygen consumption were measured. Heart rate and mean aortic pressure were kept constant, and atrial filling pressure was varied from 5 to 20 cm H2O. Heart weights of SH and CH were equal and end-diastolic pressures and volumes were similar at all atrial pressures. However, ejection fraction, calculated circumferential fiber velocity, peak systolic pressure, peak aortic flow, cardiac output, and stroke work were all greater in CH than in SH, and the differences increased as atrial pressure was increased. Maximal negative dP/dt was greater in CH than SH at all preloads (P less than 0.001). Oxygen consumption of CH was increased in proportion to the increase in work. These results indicate that the improved pumping performance of CH is due to a change in ventricular muscle function. Faster relaxation is a prominent effect of physical training on the rat heart and may foster more complete filling at high heart rates.
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004395:Dye Dilution Technique; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006352:Heart Ventricles / Q000033:anatomy & histology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009929:Organ Size; D010101:Oxygen Consumption / Q000187:drug effects; D010805:Physical Conditioning, Animal; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012212:Rheology; D013550:Swimming
chemical_list: D011433:Propranolol; D007545:Isoproterenol