Quantitative histological changes in isoproterenol induced cardiac growth.
In female rats daily injections of isoproterenol (0.3 mg/kg) produced a 40% myocardial growth within 10 days. Approximately 75% of the total growth was associated with increased muscle fiber size. The number of nuclei in muscle tissue was not affected while the nuclear population in the interstitial tissue was significantly increased.
D000818:Animals; D001835:Body Weight; D006332:Cardiomegaly / Q000473:pathology; D005260:Female; D006321:Heart / Q000187:drug effects*; D006965:Hyperplasia / Q000473:pathology; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D051381:Rats
D007545:Isoproterenol