title: Interrelations between specialized cells, capillaries and intermediary cyto-fibrillar elements, IXth note. The fibrillar apparatus of the human dermis during ageing.
abstract: The dynamics of mean density on conventional microscopic field method of the fibrillar apparatus (collagenous, elastic and reticular fibers and fragments) both in the papillary and profound dermis is followed up. In this study 40 fragments of human skin from 4 groups were included: children, adults, aged people with lesions of senile keratosis and without lesions of senile keratosis. Some histological and biochemical data from the literature were confirmed. Using the conventional microscopic field method a new element was proved, namely: the changes connected with age are significant and present a stereotypic succession; However, these changes are not always similarin intensity and direction for the three varieties of the fibers and in both layers of the dermis. An increase tendency of the fibrillar apparatus beginning from the childhood to the adulthood and then a differentiated decrease or stabilization towards the old age with the appearance of senile keratosis lesions were noticed. During ageing the fibrillar elements of the dermis become thickened and fragmented, with implications on the physiological functions of the skin.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D002196:Capillaries / Q000166:cytology; D002648:Child; D002675:Child, Preschool; D003094:Collagen; D003239:Connective Tissue Cells; D004547:Elastic Tissue / Q000166:cytology; D006801:Humans; D007223:Infant; D007642:Keratosis / Q000473:pathology*; D008875:Middle Aged; D012867:Skin / Q000098:blood supply / Q000166:cytology; D012879:Skin Physiological Phenomena
chemical_list: D003094:Collagen