Experimental induction of melanotic tumors in syrian golden hamsters by transplacental and topical application of ethylnitrosourea.
Pregnant Syrian golden hamsters were treated with a single intra-peritoneal injection of ethylnitrosourea (ENU) solution a few hours pre-parturition. Offspring either received no further treatment or from 6 weeks of age, bi-weekly application of ENU solution in acetone for 20 consecutive weeks. Progeny from non, transplacentally treated mothers were also treated topically. Among all treated groups, 8.6% of the animals developed pigmented skin tumors, most of these animals having received the combined treatment. This group also showed a significantly decreased latency period in females compared to males. One of the skin tumors, which was histologically and clinically benign, was transplanted several times and subsequently exhibited malignant features.
D000818:Animals; D006224:Cricetinae; D005038:Ethylnitrosourea / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D008297:Male; D008545:Melanoma / Q000139:chemically induced*; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D010920:Placenta; D011247:Pregnancy; D011270:Pregnancy, Animal; D012878:Skin Neoplasms / Q000139:chemically induced*
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea