Enhancement of insulin secretion by human chorionic somatomammotropin and related hormones.
Hypophysectomized rats were treated for 6 days with 200 mug per day of either human chorionic somatomammotropin, human pituitary growth hormone, plasmin-modified human pituitary growth hormone, or ovine prolactin. All hormone preparations except ovine prolactin enhanced the ability of the pancreases of hypophysectomized rats to secrete insulin in the isolated pancreas perfusion system.
D000818:Animals; D005341:Fibrinolysin; D013006:Growth Hormone / Q000494:pharmacology; D007016:Hypophysectomy; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010928:Placental Lactogen / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D007328:Insulin; D011388:Prolactin; D013006:Growth Hormone; D010928:Placental Lactogen; D005341:Fibrinolysin