A necropsy case of interstitial nephritis probably related to cefazolin and methenamine.
It is the purpose of this paper to alert the medical community on the potential nephrotoxicity of certain agents among certain patients, especially with some types of renal insufficiency. A young man, who was suffering from apparent renal disturbance, died of massive, post-operative bleeding accompanied by uremia. The uremia occurred within a very rapid clinical course and was related apparently to treatment with methenamine, a ruinary disinfectant, and cefazolin, a cephalosporin derivative. The patient was proved to have a fatal, servere interstitial nephritis based on gross and histological findings of the necropsied kidney, i.e., intense cell infiltration mainly in the interstitum of the cortex, absence of glomerular involvement, and marked softening and enlargement. The present case may suggest how to treat patients suffering from untoward renal ailments with various antibiotics.
D000328:Adult; D002437:Cefazolin / Q000009:adverse effects* / Q000627:therapeutic use; D002511:Cephalosporins / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008709:Methenamine / Q000009:adverse effects* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000150:complications / Q000209:etiology; D014511:Uremia / Q000139:chemically induced* / Q000150:complications
D002511:Cephalosporins; D002437:Cefazolin; D008709:Methenamine