[Role of the liver in detoxification of endotoxins].
I. Contribution of the reticuloendothelial system to the defence of the organism against endotoxins: phagocytic function, blood clearance and detoxifying function. II. Endotoxin--liver cell interaction. A) The effects of endotoxin on the parenchymatous liver cell; morphofunctional alterations: endotoxicosis as a "set of hepatic metabolic lesions". B) The sensitivity to endotoxin of organisms whose liver has undergone a functional alteration. III. Intrahepatic detoxification of endotoxin--an enzymatic process:--the role of enzymes oxidizing fatty acids;--the role of enzymes containing SH groups; --the role of tryptophane-oxygenase. IV. Conclusions.
D000818:Animals; D001711:Biotransformation; D004731:Endotoxins / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D012157:Mononuclear Phagocyte System / Q000502:physiology; D010587:Phagocytosis
D004731:Endotoxins
Rolul ficatului in detoxificarea endotoxinelor