[Comparative study on the effect of anticholinergic substances on basic gastric secretion as well as on gastric secretion stimulated by pentagastrin or hypoglycemia (author's transl)].
The effect of orally administered ipratropiumbromide and propanthelinbromide on the basic gastric secretion as well as on the gastric secretion stimulated by pentagastrin or hypoglycemia due to application of insulin was tested intraindividually in a double blind comparative study. Drug dosage and time after the drug effect was measured varied. In addition the anticholinergic effect of ipratropiumbromide on the basic as well as on the gastric secretion stimulated by pentagastrin was compared to that of oxacepam. The inhibitory effect of ipratropiumbromide on the basic gastric secretion as well as on the secretion stimulated by pentagastrin and hypoglycemia is more pronounced than that of propanthelinbromid. The effect on the basic secretion reached its peak 450 min after drug application whereas the maximal effect on pentagastrin stimulated secretion showed earlier. The effect described was only seen with a dose of the anticholinergic drug of at least 30 mg. A combination of ipratropiumbromide+oxacepam has no effect stronger than ipratropiumbromide alone. On the contrary, it rather seems to have an augementative effect on pentagastrin stimulated gastric secretion that may be compensated completely by ipratropiumbromide. On the basic of these results a direct influence of anticholinergic substances on the parietal cell is discussed.
D000328:Adult; D001286:Atropine Derivatives; D004305:Dose-Response Relationship, Drug; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007328:Insulin / Q000494:pharmacology; D009241:Ipratropium / Q000494:pharmacology*; D008297:Male; D010076:Oxazepam / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology*; D011413:Propantheline / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors
D001286:Atropine Derivatives; D007328:Insulin; D011413:Propantheline; D010076:Oxazepam; D010418:Pentagastrin; D009241:Ipratropium
Vergleichende Untersuchungen über die Wirkung von Anticholinergika auf die basale und die durch Pentagastrin und Hypoglykämie stimulierte Magensekretion