Non-random centromere division: a mechanism of non-disjunction causing aneuploidy?
Early centromere separation was investigated in 12 normal children, 14 patients with Down's syndrome and in 12 patients of children with autosomal trisomies. A significantly non-random centromere division of chromosomes was found in each of the cases. A higher frequency of early separated G chromosomes was observed in Down's syndrome. In 2 mothers of trisomy-18 patients, the early division of chromosomes 18, generally seen in normal individuals, could not be demonstrated. The possible assoication between altered sequence of centromere disision and non-disjunction needs further confirmation.
D000782:Aneuploidy; D002455:Cell Division; D002503:Centromere / Q000648:ultrastructure*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000648:ultrastructure*; D002877:Chromosomes, Human; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D014314:Trisomy