Mutation induction by the antischistosomal drug F30066 in various test systems.
The genetic activity of furapromidium (F30066), an antischistosomal drug, was studied in Salmonella typhimurium, Saccharomyces cerevisiae, Neurospora crassa and cultured Chinese hamster cells. The results show that F30066 induces gene mutations in S. typhimurium, N. crassa and Chinese hamster cells. This compound also causes gene conversions in S. cerevisiae.
D000178:Acrylamides / Q000494:pharmacology; D002478:Cells, Cultured; D005796:Genes / Q000187:drug effects; D009153:Mutagens; D009492:Neurospora crassa / Q000378:metabolism; D009581:Nitrofurans / Q000494:pharmacology*; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012486:Salmonella typhimurium / Q000378:metabolism; D012556:Schistosomicides / Q000494:pharmacology*
D000178:Acrylamides; D009153:Mutagens; D009581:Nitrofurans; D012556:Schistosomicides