[Simultaneous liberation of vasopressin (ADH) and of neurophysins during nicotine perfusion in man].
Using the radioimmunoassay (R.I.A.) for neurophysins (I.R.N.) described in 1969, we demonstrated a concomitant, rapid release of both A.D.H. and I.R.N. within the first minutes (2') of the i.v. infusion of nicotine in 11 patients with normal neuropituitary function and 1 patient suffering from a Schwartz-Bartter syndrome. There is a close relationship (r : 0,82, p less than 0.001) similar to that described by other authors, between peak levels of A.D.H. and I.R.N. in all the patients. Hence, we proved that our R.I.A. system is influenced by nicotine stimulated neurophysins (N.S.N.). The negative results previously published by two of us in 5 normal men could have been due to the length of the period between the beginning of the test and the first blood sampling (30 mn).
D006801:Humans; D007263:Infusions, Parenteral; D009481:Neurophysins / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects*; D011863:Radioimmunoassay; D014667:Vasopressins / Q000378:metabolism*
D009481:Neurophysins; D014667:Vasopressins; D009538:Nicotine
Libération simultanée de vasopressine (A.D.H.) et de neurophysines lors de la perfusion de nicotine chez l'homme.