title: [Experience with using leukocytic interferon with methacil in influenza in children].
abstract: For prophylaxis influenza in the infection foci under stationary conditions 213 children were treated with leucocytic interferon with metacyl and 192 children were observed as the control group. The drug was administered intranasally in a dose of 0.25 ml once a day. The observations showed that among the children treated prophylactically with interferon and metacyl the number of influenza cases decreased 2.17 times a compared to the control group. In contact children who were taken ill with influenza the severety of the infection and the number of complications decreased. Under the stationary conditions in the children treated with interferon and metacyl the numbers of the wave-like infection and complications decreased 2.5 and 2.9 times respectively as compared to the children not treated with the drugs. Addition of metacyl to leucocytal interferon provided its administration once a day instead of 3-4 times a day.
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control; D007372:Interferons / Q000009:adverse effects / Q000627:therapeutic use*; D007962:Leukocytes; D010919:Placebos; D012426:Russia; D014498:Uracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010919:Placebos; D014498:Uracil; D007372:Interferons
vernacular_title: Opyt primeneniia leĭkotsitarnogo interferona s metatsilom pri grippe u deteĭ