title: Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas.
abstract: The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5alpha-dihydrotestosterone and 5alpha-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C19 steroids by rat mammary adenocarcinomas.
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D015113:Androstane-3,17-diol / Q000378:metabolism; D000818:Animals; D004273:DNA, Neoplasm / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D011388:Prolactin / Q000097:blood* / Q000494:pharmacology; D051381:Rats; D013739:Testosterone / Q000378:metabolism*
chemical_list: D004273:DNA, Neoplasm; D015113:Androstane-3,17-diol; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011388:Prolactin