[Comparative study of a vagolytic and a beta 2 sympathomimetic drug on the respiratory function of the asthmatic patient].
The authors compared the effects of a synthetic vagolytic drug, the SCH 1000, and a beta2 sympathicomimetic one (Fenoterol) in two groups of control children (n = 11) and two groups of asthmatic children (n = 23). They studied the following parameters, flow volumes curves, steady state lung diffusing capacity and the blood gases. No difference of efficiency was found between the two types of bronchodilators although the graphic modification of flow volumes curves was different after Fenoterol and after SCH 1000. The modifications consisted in a great improvement in instantaneous flow, a decrease in diffusion capacity and an increase of the Pa O2 significant in the group of asthmatic children after Fenoterol.
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology / Q000627:therapeutic use*; D008176:Lung Volume Measurements; D008297:Male; D010100:Oxygen / Q000097:blood; D011653:Pulmonary Diffusing Capacity; D014692:Ventilation-Perfusion Ratio
D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D004983:Ethanolamines; D005280:Fenoterol; D009241:Ipratropium; D010100:Oxygen
Etude comparative d'un vagolytique et d'un beta2 sympathicomimétique sur la fonction respiratoire de l'asthmatique.