title: Effects of allogeneic stimulations on the proliferation and differentiation of the hemopoietic stem cell.
abstract: The effects of allogeneic stimulatins on the hemopoietic system were investigated. Spleen cells of mice activated in vivo with alloantigens were able to produce highly active colony-stimulating factor in the culture medium without any stimulation. But spleen cells of these mice could not release colony-stimulating factor after treatment in vitro with anti-theta serum and complement. The number of granulopoietic progenitor cells (colony-forming unit-culture) in both bone marrow and spleen cells of mice treated with such procedures was significantly greater than that of the control, and the number of pluripotent stem cells (colony-forming unit-spleen) of these mice was markedly increased compared with that of the control, especially in spleen cells. These experiments suggest that T lymphocytes activated in vivo with alloantigens may release active substances in the differentiation and proliferation of hemopoietic stem cells.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D003115:Colony-Stimulating Factors; D005260:Female; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007519:Isoantigens; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000502:physiology*; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D003115:Colony-Stimulating Factors; D007519:Isoantigens