Karyological and electron-microscopic studies in myocardial cells of primates after experimentally induced cardiac hypertrophy.
Precocious polyploidization in hypertrophic hearts of infants with congenital malformation can be reproduced banding the ascending aorta of young rhesus monkeys. Electron micrographs show hypoxic changes, signs of DNA, RNA, and protein synthesis as well as degenerative changes comparable to human hearts. Enforced polyploidization of cor pulmonale is found in rhesus exposed to coal quartz dust for 48 months. The pig heart, containing disturbed mitoses, serves as a model for incomplete mitoses. During evolution they became the rule for the myocardial cells of primates.
D000818:Animals; D006332:Cardiomegaly / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D000882:Haplorhini; D008251:Macaca; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000235:genetics* / Q000473:pathology; D009206:Myocardium / Q000648:ultrastructure*; D011123:Polyploidy