Effect of streptozotocin on the blood glucose level and histology of the principal islets of Channa punctatus (Bloch).
The effect of streptozotocin, an antibiotic and diabetogenic drug, has been studied on the blood glucose level and islet histology of a freshwater fish, Channa punctatus. The drug elicits a triphasic response in the blood glucose level, comprising an initial hyperglycemia followed by a transient fall, and restitution of normal values 3...4 days after the treatment. Significant degenerative changes occur in the islet beta cells. Severity of the beta cell damage is dose dependent and the drug has been found to be beta-cytotoxic to a considerable extent. Unlike mammals, Channa punctatus does not become diabetic following the streptozotocin administration, at doses varying 200-400 mg/kg b.wqnd over a period of 96 hours post-injection.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005399:Fishes / Q000033:anatomy & histology* / Q000097:blood; D007515:Islets of Langerhans / Q000033:anatomy & histology* / Q000187:drug effects; D008297:Male; D013311:Streptozocin / Q000494:pharmacology*
D001786:Blood Glucose; D013311:Streptozocin