The effects of p-chlorophenylalanine, reserpine, methysergide and cyproheptadine on the dopa-induced EEG synchronization in the rat.
The actions of drugs interfering with central indolaminergic mechanisms were assessed on the Dopa-induced EEG synchronization in the rat. The increased slow wave activity observed during the first 30 min following Dopa (100 mg/kg) was significantly decreased by p-chlorophenylalanine (400 mg/kg), reserpine (4 and 8 mg/kg) and methysergide (16 mg/kg). Cyproheptadine was ineffective in this respect. Our findings lend support to the hypothesis that the initial synchronization after Dopa is related to the release of 5-hydroxytryptamine.
D000818:Animals; D003344:Cortical Synchronization; D003533:Cyproheptadine / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004347:Drug Interactions; D004569:Electroencephalography; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*
D003533:Cyproheptadine; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D012110:Reserpine; D010134:Fenclonine; D008784:Methysergide