Lack of mutagenicity of vinyl chloride in two strains of Neurospora crassa.
No detectable induction of mutations could be found in two strains of Neurospora crassa after their conidia were treated with vinyl chloride, in ethanol solution and in its gaseous form. The results suggest that although N. crassa seems to lativating systems does not increase mutagenic activity of vinyl chloride in the two strains tested. At the same time these strains were mutated easily by UV and methyl methanesulfonate.
D000336:Aerosols; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009491:Neurospora / Q000187:drug effects*; D009492:Neurospora crassa / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014752:Vinyl Chloride / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D000336:Aerosols; D009153:Mutagens; D014753:Vinyl Compounds; D008741:Methyl Methanesulfonate; D001189:Aryl Hydrocarbon Hydroxylases; D014752:Vinyl Chloride