title: Renal hypertrophy in streptozotocin-diabetic rats.
abstract: 1. Kidney weight and content of protein, RNA and DNA were measured in rats with streptozotocin diabetes of varying duration. 2. Diabetic rats had larger  kidneys than control rats: after 3 days of diabetes the weight increase was 15 per cent and after 42 days of diabetes it was 90 per cent. The protein content rose in parallel to the weight. 3 RNA content was already increased after 36 h of glycosuria, whereas DNA content was unchanged for the first 3 days of diabetes, and increased thereafter. The protein/DNA ratio increased rapidly during the first 3 days but remained constant thereafter. 4. Insulin treatment decreased the renal weight gain by about 67 per cent during the first 8 days of diabetes, but did not prevent the increase in DNA. When insulin was started after 25 days of diabetes there was only a slight regression of kidney growth.
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000473:pathology*; D006029:Glycosuria / Q000378:metabolism; D006984:Hypertrophy; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013311:Streptozocin
chemical_list: D007328:Insulin; D011506:Proteins; D013311:Streptozocin; D012313:RNA; D004247:DNA