[Effects of ethinyl estradiol compared with norethisterone (pure or contaminated) on vaginal keratinization of castrated rats].
Norethisterone samples are often contaminated by estrogen traces which can be measured by mass spectrometry and which invest the progestative with estrogenic properties in the Allen and Doisy test. Therefore, one had better, in pharmacodynamic experimenting, use samples that have been purified by chromatography or that are pure out of synthesis. However, one will not forget these are not without some estrogenicity, a fact which seems linked to the very nature of the norethisterone molecule.
D000818:Animals; D002369:Castration; D004340:Drug Contamination; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D007633:Keratins / Q000096:biosynthesis*; D009640:Norethindrone / Q000494:pharmacology*; D051381:Rats; D014621:Vagina / Q000187:drug effects* / Q000378:metabolism
D004997:Ethinyl Estradiol; D007633:Keratins; D009640:Norethindrone
Actions comparées de l'éthinylestradiol et de la noréthistérone pure ou non sur la kératinisation vaginale de la ratte castrée