Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo.
T4 heteroduplex heterozygotes are lost selectively after prolonged incubation of phage-infected Escherichia coli cells under nonreplicating conditions. The loss of heterozygosity occurs for four out of six rII sites tested and is not dependent upon T4 v gene function. The results are interpreted to indicate the existence of a base-specific system for the recognition of mismatched bases in intracellular DNA.
D003090:Coliphages / Q000254:growth & development* / Q000378:metabolism; D004279:DNA, Viral / Q000096:biosynthesis; D005467:Floxuridine / Q000494:pharmacology; D006579:Heterozygote; D009154:Mutation; D014779:Virus Replication
D004279:DNA, Viral; D005467:Floxuridine