Coronary blood flow and myocardial O2 consumption in hypertrophied cardiac muscle in dogs.
In dogs with experimental cardiac hypertrophy in resting conditions, coronary blood flow and myocardial O2 consumption increased proportionately to the cardiac mass; coronary flow and O2 consumption per gram of myocardium, therefore, ranged within normal values. The coronary reserve, neasured as the percentage increase in the coronary blood flow from rest till peak flow during reactive hyperaemia, was noticeably reduced, because it was partially utilized, even at rest, and consequently the possibility of an increase in flow after exercise or stress was diminished.
D000818:Animals; D002302:Cardiac Output; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology*; D003326:Coronary Circulation; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D009206:Myocardium / Q000378:metabolism*; D005996:Nitroglycerin / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D014655:Vascular Resistance
D004176:Dipyridamole; D005996:Nitroglycerin