Investigations of the cell cycle of malignant tumors in oto-rhino-laryngology and their significance for cytostatic treatment (author's transl).
45 patients with advanced malignant tumors in head and neck were treated with a cytostatic combination chemotherapy. In the beginning of cytostatic treatment surgical- and radiotherapy were no more possible. The duration of the generation-cycle of the tumor cells was determined autoradiographically with the double labelling method. Most of the patients showed a measurable diminution of tumors and a following stop of tumor growth. In spite of severe complications it was possible, to achieve a prolongation of live with a supportable feeling. A five year curing was not observed.
D002455:Cell Division; D003520:Cyclophosphamide / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D004273:DNA, Neoplasm; D014750:Vincristine; D003520:Cyclophosphamide; D008775:Methylprednisolone; D008727:Methotrexate
Untersuchungen zum Generationszyklus maligner Tumoren im HNO-Bereich und ihre Bedeutung für die zytostatische Therapie