Reciprocal translocations in man. 3:1 Meiotic disjunction resulting in 47- or 45-chromosome offspring.
Five cases of chromosome imbalance resulting from 3:1 disjunction of reciprocal translocations are described. A review of the literature suggests this phenomenon is more common than has previously been recognized.
D000015:Abnormalities, Multiple / Q000235:genetics; D000328:Adult; D000367:Age Factors; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D008297:Male; D008423:Maternal Age; D008540:Meiosis; D010375:Pedigree; D012008:Recurrence; D012306:Risk; D014178:Translocation, Genetic; D014314:Trisomy