[The effect of sodium and potassium ions on serotonin absorption by lung tissue].
Experiments were conducted on the isolated perfused lungs of albino rats; there was shown a dependency of serotonin (ST) absorption on the Na+ and K+ concentration in the perfusate. Which high Na+ concentrations in the perfusate ST was absorbed by the lung tissue cells in great quantities, but when Na+ concentrations were low - ST absorption showed a sharp reduction. K+ concentration in the perfusate had a lesser influence on the ST absorption; the maximal absorption was seen with the K+ concentrations of from 5 to 20 mM. A reduction or an increase in the K+ concentration inhibited the ST absorption. Strophanthin K, a powerful Na, K-dependent ATPase inhibitor, markedly inhibited the ST absorption in a concentration of 10(-4)-- 10(-3) M. It is supposed that there was an association of the ST transport through the cell membrane with the Na+ transport.
D000042:Absorption; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000201:enzymology / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology*; D013328:Strophanthins / Q000494:pharmacology
D013328:Strophanthins; D012701:Serotonin; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium
Vliianie ionov natriia i kaliia na pogloschenie serotonina legochnoĭ tkan'iu