HL-A frequencies in Down's syndrome.
HL-A antigen frequencies were examined in 76 Down's syndrome individuals and 733 normal Caucasians. 10 antigens of the first locus and 15 antigens of the second locus were defined, using a microlymphocytotoxicity technique. No significant differences were observed between the normal and Down's syndrome samples, in contrast to a previous report (Boxer and Yokoyama, 1972) of decreased HL-A antigen frequencies in Down's syndrome individuals. Our results therefore suggest that there is no relationship between trisomy 21-associated immune aberrations and altered HL-A antigen frequencies.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D004314:Down Syndrome / Q000276:immunology*; D005787:Gene Frequency; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D008875:Middle Aged
D006680:HLA Antigens; D006649:Histocompatibility Antigens