[Functional, morphologic and histochemical changes in the myocardium and their role in the development of cor pulmonale following pulmonary resection].
Functional, morphological and histochemical alterations were studied in 32 dogs within the period of 5 days--18 months after resection of 32-80% of the pulmonary tissue. According to the presence of hypertrophy of the heart right ventricle wall, morphological changes of the myocardium and disorders in the functional features of the cardiovascular activity all the animals were divided into 4 groups: 1--control animals; 2--experimental animals without hypertrophy of the right ventricle wall; 3--experimental animals with hypertrophy of the right ventricle wall in the stage of compensation; 4--experimental animals with hypertrophy of the right ventricle wall in the stage of decompensation. In the myocardium of the second group animals a decrease of aerobic processes and an increase of anaerobic ones were found to take place. The aerobic processes increased and the anaerobic processes decreased in the myocardium of dogs having hypertrophy of the right ventricle wall in the stage compensation. In the muscle of the decompensated pulmonary heart there occurred a pronounced decrease of aerobic and anaerobic processes, a disturbance of the protein and fat metabolism. All this resulted in a decreased contractive function of the myocardium with distrubed hemodynamics. The investigations have shown the interrelationships of morphological, histochemical and ECG alterations in the dynamics of the pulmonary heart development after resection of lungs.
D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D006003:Glycogen / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006321:Heart / Q000503:physiopathology; D006651:Histocytochemistry; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011013:Pneumonectomy / Q000009:adverse effects*; D011660:Pulmonary Heart Disease / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000378:metabolism
D006025:Glycosaminoglycans; D006003:Glycogen; D013385:Succinate Dehydrogenase
Funktsional'nye, morfologicheskie i gistokhimicheskie izmeneniia v miokarde i znachenie ikh v razvitii dekompensatsii legochnogo serdtsa posle rezektsii legkikh