Tape test as a simple new method for the study of compounds increasing the problem-solving ability of the rat.
A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected learning-dull rats were used which were unable to remove the tape within 60 s observed on 3 consecutive days. The problem-solving ability of the rats was studied on 4 consecutive days, by posttrial administration. The problem-solving ability was found to be increased after treatment with different drugs such as para-chlorphenylalanine (PCPA), pemolin, orotic acid, vitamin B12. The stimulatory effect of vitamin B12 could be inhibited by vincristine.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D009963:Orotic Acid / Q000494:pharmacology; D010389:Pemoline / Q000494:pharmacology; D011340:Problem Solving / Q000187:drug effects* / Q000502:physiology; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013268:Stimulation, Chemical; D014750:Vincristine / Q000494:pharmacology; D014805:Vitamin B 12 / Q000494:pharmacology
D014750:Vincristine; D009963:Orotic Acid; D012313:RNA; D010389:Pemoline; D014805:Vitamin B 12; D010134:Fenclonine