[On the carcinogenetic action of N-nitroso compounds. 7th communication: methyl-, trideuteromethyl-, ethyl-, n-propyl-, n-butyl-, acetoxymethyl-nitrosamine, and methyl-butyroxymethyl-nitrosamine (author's transl)].
The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.
D000478:Alkylation; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D008745:Methylation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D009602:Nitrosamines
Zur carcinogen Wirkung von N-Nitroso-Verbindungen. 7. Mitteilung: Methyl-, Trideuteromethyl-, Athyl-, n-Propyl, n-Butyl-, Acetoxymethyl-Nitrosamin und Methyl-Butyroxymethyl-Nitrosamin.