title: Products of the major histocompatibility complex and their relationship to the immune response.
abstract: The genes of the major histocompatibility complex were first known for the part they played in transplant rejection. Recently, however, it has become clear that the products of that region have an important part to play in the control of the immune response, through their effects both on cooperative and on aggressive interactions between cells. It is now possible to guess at the mechanisms which may underly the association of some major histocompatibility antigens with disease.
mesh_terms: D000483:Alleles; D000818:Animals; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002874:Chromosome Mapping; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D005787:Gene Frequency; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens; D006649:Histocompatibility Antigens / Q000145:classification; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007111:Immunity, Cellular; D007519:Isoantigens; D007945:Leukemia, Lymphoid / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D044465:White People; D001613:beta 2-Microglobulin / Q000276:immunology
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007519:Isoantigens; D008565:Membrane Proteins; D001613:beta 2-Microglobulin; D003165:Complement System Proteins