Generalized exfoliative dermatitis from ethylenediamine.
A patient with a history of allergic reaction to an antibiotic cream (Mycolog [mixture of nystatin, neomycin sulfate, gramicidin, and triamcinolone acetonide]) was treated with aminophylline. A generalized exfoliative dermatitis resulted. The reaction was attributable to ethylenediamine hydrochloride, which is a component of both agents. Recognition of the potential for systemic medications to induce similar reactions in patients who are allergic to related topical preparations is important when prescribing systemic agents.
D000628:Aminophylline / Q000009:adverse effects / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000209:etiology*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D004342:Drug Hypersensitivity; D004347:Drug Interactions; D005029:Ethylenediamines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000188:drug therapy
D005029:Ethylenediamines; D000628:Aminophylline