Carcinogenicity of N-nitrosopyrrolidine: dose-response study in rats.
Results from a dose-response study in rats are reported, in which daily oral doses of 10, 3, 1, and 0.3 mg/kg bodyweight/day respectively were administered. The three highest dose levels resulted in incidences of liver cancer of 46, 84, and 32% respectively. In the lowest dose group (0.3 mg/kg/day) no statistically significant increase in tumor rate compared to untreated controls was found.
D000818:Animals; D001943:Breast Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D011759:Pyrrolidines / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats
D002273:Carcinogens; D011759:Pyrrolidines