The influence of actinomycin D on the activity of delta-aminolaevulinic acid synthetase and dehydratase in the liver of mice and rats treated by griseofulvin.
The changes of delta-aminolaevulinic acid dehydratase--the second enzyme of porphyrin synthesis--were studied and compared in the liver of mice and rats treated with griseofulvin. The results showed that griseofulvin increased the activity of delta-aminolaevulinic acid dehydratase in the liver of mice and rats treated by griseofulvin. No differences were found between mice and rats as to the effect of griseofulvin on the activity of delta-aminolaevulinic acid dehydratase. The influence of the administration of actinomycin D on the activity of delta-aminolaevulinic acid synthetase and dehydratase in the liver of mice and rats was studied at an early period of experimental porphyria induced by griseofulvin. It was found that the administration of actinomycin D blocked the observed effect of griseofulvin on the activity of both enzymes in the liver of mice and rats.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D005260:Female; D006118:Griseofulvin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006836:Hydro-Lyases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D000623:Porphobilinogen Synthase / Q000378:metabolism*; D011164:Porphyrias / Q000139:chemically induced / Q000201:enzymology; D051381:Rats
D003609:Dactinomycin; D006118:Griseofulvin; D000624:5-Aminolevulinate Synthetase; D006836:Hydro-Lyases; D000623:Porphobilinogen Synthase