[Effect of various organic substances on the activity of the membrane preparations of Na, K-ATPase].
The effect of guanidine, lisine, arginine, acetamide and urea on the activity of the preparations of Na, K-ATPase from guinea pig kidney was studied. It was established that the enzymatic activity of the preparations can be lowered by 50% by the following concentrations of the substances examined: guanidine--0.07 M, argine--0.12 M, lisine--0.30 M, acetamide--0.95 M, urea--1.05 M. There correlation among the inhibitory ability of these substances and their basis properties.
D000081:Acetamides / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000255:Adenosine Triphosphate; D001120:Arginine / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D006146:Guanidines / Q000494:pharmacology; D007672:Kidney Cortex / Q000166:cytology / Q000201:enzymology*; D008239:Lysine / Q000494:pharmacology; D011188:Potassium; D012964:Sodium; D014508:Urea / Q000494:pharmacology
D000081:Acetamides; D006146:Guanidines; D000255:Adenosine Triphosphate; D014508:Urea; D001120:Arginine; D012964:Sodium; D000251:Adenosine Triphosphatases; D008239:Lysine; D011188:Potassium
Vliianie nekotorykh organicheskikh osnovaniĭ na aktivnost' membrannykh preparatov Na, K-ATFazy.