title: [Gene duplication and protein evolution. Case of aminoacyl-t-RNA synthetases].
abstract: Aminoacyl-tRNA synthetases are a functionally homologous group of enzymes which catalyse the first step of protein synthesis. The accumulation of data on the oligomeric structures of these enzymes has revealed a wide diversity in the sizes and organization of the protomers. This is not consistent with the idea of a family with homologous primary and tertiary structures. Howewer recent studies have shown that all these enzymes may have evolved from a common ancestor through gene duplication and fusion which has led to extensive repeating sequences in the corresponding subunits.
mesh_terms: D000595:Amino Acid Sequence; D000604:Amino Acyl-tRNA Synthetases; D000818:Animals; D005075:Biological Evolution; D046911:Macromolecular Substances; D011487:Protein Conformation
chemical_list: D046911:Macromolecular Substances; D000604:Amino Acyl-tRNA Synthetases
vernacular_title: Duplication génique et évolution des protéines. Cas des aminoacyl-tRNA synthétases.