[Reversal of the depressive power of cyclophosphamide on the anti-infectious defense of the mouse by means of a somatic antigen from Bacillus subtilis].
In the experimental conditions reported the cyclophosphamide increases the pathogenic effect of Escherichia coli in mice. Treating the animals with a somatic antigen of Bacillus subtilis, reverses the aggravating effect of cyclophosphamide on the experimental infection. Similar results are obtained through the parenteral and the rectal routes. This antigen does not limit either the leucopenient effect of cyclophosphamide nor its blocking effect on the synthesis of sheep red blood cells antibody in mice.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001412:Bacillus subtilis / Q000276:immunology; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004927:Escherichia coli Infections / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D013268:Stimulation, Chemical
D000942:Antigens, Bacterial; D003520:Cyclophosphamide
Réversion du pouvoir dépresseur de la cyclophosphamide envers la défense anti-infectieuse de la Souris au moyen d'un antigène somatique de Bacillus subtilis