title: Special topical approach to the treatment of acne. Suppression of sweating with aluminum chloride in an anhydrous formulation.
abstract: A new topical approach to acne treatment--the use of aluminum chloride hexahydrate in anhydrous ethanol (ACAE)--was studied in 141 patients. Using sequential treatment schedules, paired comparison techniques, and various concentrations of ACAE, we established maximal efficacy with minimal local irritation for the 6.25% strength solution. Clinical efficacy and lack of toxicity of this formulation were confirmed by the additional clinical study of 65 patients. The antiperspirant and antibacterial actions of 6.25% ACAE solution were then verified on acne skin areas. It is postulated that the clinical improvement in acne that follows the topical use of ACAE results from one or both of these actions.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000890:Anti-Infective Agents; D004339:Drug Compounding; D000431:Ethanol; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012996:Solutions; D013546:Sweating / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D012996:Solutions; D000431:Ethanol; D000535:Aluminum