title: Down's syndrome: karyotypic stability of trisomy 21 in an established lympho-blastoid cell line.
abstract: A trisomic lymphoblastoid cell line derived from the peripheral blood of a patient with Down's syndrome was sequentially analyzed for chromosome constitution for 16.5 months of continuous culture in vitro. The cell line was found to maintain a modal chromosome number of 47 with trisomy 21. Parallel studies of modal chromosomes before and after banding procedures revealed no structural abnormalities except trisomy 21.
mesh_terms: D002460:Cell Line; D002648:Child; D002904:Chromosomes, Human, 21-22 and Y; D004314:Down Syndrome / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D014314:Trisomy