[The role of hypocalcemia on cell renewal and migration in the oral epithelium of the rat].
Calcium plays an important role in phenomena relating to permeability and regulation of the extracellular compartments. The diffusion anomalies of sulphur previously observed in the oral epithelium of the hypocalcemic rat could possibly be attributed to a reduction in diffusion of sulphur related to disturbances in cellular renewal. The injection of H3 thymidine was used to compare in parathyroidectomized and control rats the resultant differences in DNA synthesis and the migration of labelled cells. The labelling indices showed the absence of any relation between DNA synthesis and a calcium deficiency, whereas, on the contrary, hypocalcemia should produce modifications of the labelled cell distribution in the control and experimental rats. This difference indicates a reduction in cellular migration in case of hypocalcemia.
D000818:Animals; D002118:Calcium / Q000097:blood; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D004848:Epithelium / Q000473:pathology; D006996:Hypocalcemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology*; D016105:Parathyroidectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D002118:Calcium; D013936:Thymidine
Rôle de l'hypocalcémie sur le renouvellement et la migration cellulaire de l'épithélium buccal du rat.