[Effect of narcotics on the enzymatic activity of neuronal and synaptic mitochondria of rat brain].
The action of morphine (20 mg/kg) and phenobarbital (80 mg/kg) on the activity of acetylcholinesterase (ACS) and Mg2+-dependent ATP-ase in fractions of unpurified mitochondria and neuronal mitochondria of the rats brain was studied. It is shown that with prolonged introduction of both morphine and phenobarbital the dynamics of the Mg2+-dependent ATP-ase activity in fractions of neuronal mitochondria and synaptosomes is dissimilar, the synaptosomes fractions then displaying a specific influence of morphine and phenobarbital on the Mg2+-dependent ATP-ase activity, while in the neutronal mitochondria fraction changes occurring in the activity of this enzyme proved to be analogus to those taking place after administration of both morphine and phenobarbital. The ACS activity in the synaptosomes fraction following introduction of both morphine and phenobarbital did not differ from the control one.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D007274:Injections, Intraperitoneal; D008928:Mitochondria / Q000201:enzymology*; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009474:Neurons / Q000201:enzymology; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000201:enzymology
D009020:Morphine; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D010634:Phenobarbital
Vļiianie narkoticheskikh veshchestv na fermentativnuiu aktivnost' neironal'nykh i sinapticheskikh mitokhondrii golovnogo mozga krys