Hypertrophy due to chronic volume overloading in the dog heart. A morphometric study.
Cardiac hypertrophy due to chronic volume overloading was produced in dogs by experimental complete AV-block. Ten weeks after operation a quantitative electron microscopic study was carried out for determination of the volume density of contractile material and mitochondria. The results were compared with a two-week group and normal dogs. The ratio of the volume density of contractile material and mitochondria is nearly constant during the course of developing hypertrophy.
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology*; D002908:Chronic Disease; D004285:Dogs; D006327:Heart Block / Q000150:complications; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000648:ultrastructure