title: The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders.
abstract: Comparison of the properties of blood platelets and serotonergic synaptosomes suggests that the human platelet can serve as an appropriate model for the transport, metabolism, and release of serotonin (5-HT) by CNS serotonergic neurons. The study of blood 5-HT levels and platelet 5-HT pharmacodynamics in patients with a variety of psychiatric and neurologic disorders has generated interesting leads into possible abnormalities of CNS 5-HT neurons in these patients. This article reviews the experimental evidence, which uses the human platelet model to investigate neurotransmitter-related abnormalities in Down syndrome, mental retardation, infantile autism, hyperactivity syndromes (minimal brain dysfunction), schizophrenia, affective disorders, Duchenne muscular dystrophy, Parkinson disease, Huntington chorea, and migraine headaches.
mesh_terms: D000342:Affective Symptoms / Q000378:metabolism; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism; D001321:Autistic Disorder / Q000378:metabolism; D001693:Biological Transport, Active; D001792:Blood Platelets / Q000378:metabolism*; D002463:Cell Membrane Permeability; D004314:Down Syndrome / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D008607:Intellectual Disability / Q000378:metabolism; D001523:Mental Disorders / Q000378:metabolism*; D008881:Migraine Disorders / Q000378:metabolism; D009136:Muscular Dystrophies / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D011985:Receptors, Serotonin; D012559:Schizophrenia / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin