[The intratympanic treatment of  Menière's disease with ototoxic antibiotics. A follow-up study of 55 cases (author's transl)].
Report about 55 patients suffering from severe unilateral Menières disease, seen over a period of 3-10 years. They were treated with intratympanic administration of Streptomycinesulfate or- better -Gentamycinesulfate. The medication was given using a plastic tube inserted behind the annulus by transmeatal approach. 0.1 ml Gentamycinesulfate (earlier Streptomycinesulfate were instillated every 5 hours until the first signs of inner-ear-reaction (nystagmus or vertigo) appeared. -In 90% of the cases vertiginous attacks ceased after therapy. Hearing was preserved in 76%, tinnitus and periaural pressure were influenced markedly.
D002150:Caloric Tests; D004432:Ear, Middle; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006311:Hearing Disorders / Q000139:chemically induced; D006801:Humans; D008575:Meniere Disease / Q000175:diagnosis / Q000188:drug therapy*; D013307:Streptomycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014717:Vertigo / Q000139:chemically induced
D005839:Gentamicins; D013307:Streptomycin
Die intratympanale Behandlung des Morbus Menière mit ototoxischen Antibiotika. Langzeitbeobachtung von 55 Fällen.