Hormone responsiveness of plasma membrane-bound enzymes in normal and regenerating rat liver.
The hormonal responsiveness of plasma membrane-bound enzymes (Na-+-K-+)-ATPase and adenylate cyclase has been investigated in normal and regenerating rat liver. (Na-+-K-+)-ATPase basal activity is not affected by surgery and only slightly affected by partial hepatectomy; its response to epinephrine and cyclic AMP is decreased only 15 h after hepatectomy. Adenylate cyclase activity of plasma membranes from untreated animals is stimulated by parathyroid hormone and thyroxine; partial hepatectomy increased basal activity as well as the stimulation exerted by the aforementioned hormones, when glucagon and epinephrine sensitivity is essentially unaltered.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D005459:Fluorides / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008115:Liver Regeneration / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology
D006728:Hormones; D010281:Parathyroid Hormone; D005934:Glucagon; D012964:Sodium; D000251:Adenosine Triphosphatases; D000262:Adenylyl Cyclases; D013974:Thyroxine; D005459:Fluorides; D011188:Potassium; D004837:Epinephrine