Immune complex disease associated with an infected ventriculojugular shunt: a curable form of glomerulonephritis.
A 22-year-old man with a ventriculojugular shunt had edema, hematuria, proteinuria, hypocomplementemia, azotemia, and S epidermidis bacteremia. Initial percutaneous renal biopsy showed a diffuse proliferative glomerulonephritis. Subendothelial and intramembranous deposits were seen on electron microscopy. Immunofluorescent studies were positive for IgG and C3. A repeat percutaneous renal biopsy six weeks after cessation of antibiotic therapy revealed a mild proliferative glomerulonephritis with some evidence of resolution. No deposits were seen on electron microscopy and immunofluorescent studies were negative. At elective shunt revision three months after cessation of therapy, culture of the jugular portion of the removed shunt revealed S epidermidis. Early recognition of immune complex glomerulonephritis occurring with an infected ventriculovascular shunt should permit early treatment (antibiotic therapy and removal of the infected foreign body) and a favorable outcome.
D000328:Adult; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D003176:Complement C3; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D007074:Immunoglobulin G; D008297:Male; D013203:Staphylococcal Infections
D003176:Complement C3; D007074:Immunoglobulin G