[Iatrogenic lupus-like syndromes].
The existence of iatrogenic lupus is now well-established and seems to be on the increase. A number of drugs must take the blame for these outbreaks: Hydrazine derivatives (Hydralazine, I.N.H.), anticonvulsants, Procainamide, psychotropics, antibiotics, antalgics, contraceptives. Clinically, these drugs can: --either mimic L.E. without showing any visceral or biological signs; --or aggravate a chronic L.E., or a systemic L.E. during a remission with biological symptoms appearing; --or trigger a true L.E.: all the various clinical symptoms of idiopathic L.E. may be encountered, certain articular, cutaneous symptoms predominating, renal symptoms rarely appearing. The discovery of HARGRAVES cells is the only certain biological sign to confirm systemic lupus, the existence of antinuclear antibodies or antinuclear factors merely serving as a guide to the collecting of a whole gamut of clinical and biological symptoms.
D003875:Drug Eruptions / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007592:Joint Diseases / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000473:pathology
Les syndromes lupiques iatrogéniques