[HBs-antigen induced extrahepatic immune-complex disease (author's transl)].
A 62-year old patient was hospitalized with fever, polyarthritis and exanthema. All bacteriological, virological and biochemical findings were normal. The immunological analysis showed initially the HBs-antigen in the serum. No irregular antibody was found. Chemotherapy was failing, but application of corticosteroids was followed by a dramatic improvement. Nine weeks after the onset of the disease the patient was healthy again. Antibodies against HBs-antigen were found 3 months later. The data suggest an immune-complex disease like serum sickness based on an infection with hepatitis-B-virus without involvement of the liver.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000302:isolation & purification; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D006511:Hepatitis B Antigens / Q000302:isolation & purification*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000188:drug therapy / Q000382:microbiology*; D007136:Immunoglobulins / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D006511:Hepatitis B Antigens; D007136:Immunoglobulins
HBs-Antigen-induzierte passagere extrahepatische Immunkomplexkrankheit