Steroid atrophy--a histological appraisal.
This histological changes induced by 1 month's applications of various corticorteroids to normal forearm skin were studied. Marked epidermal atrophy was present at 1 month with the more potent steroids, but the dermal changes were minimal or absent. The methods outlined in this study could serve as a useful model for assessing the unwanted atrophogenic action of potent corticosteroid preparations.
D000328:Adult; D001284:Atrophy; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D012885:Skinfold Thickness; D013997:Time Factors
D009824:Ointments; D001623:Betamethasone; D001624:Betamethasone Valerate; D006854:Hydrocortisone