Effect of different sex of tumour bearing mice and of ovariectomy on the proliferation kinetics of a solid, transplantable mammary carcinoma (C3H-mouse).
The aim of the present investigation was to study the influence of sex of tumour bearing mice and of ovariectomy on the proliferation kinetics of a solid, transplantable mammary carcinoma (C3H-mouse). According to the growth curves the tumour growth was delayed in spayed female and in male mice compared with normal female animals. This was due to a longer cell cycle time of tumour cells in the former, mainly caused by a prolonged presynthetic gap (TG1). Concerning the growth fraction and the cell loss factor, essential differences could not be detected. Thus, the solid tumour displayed a distinct though partial disengagement of growth from hormonal dependence.
D000818:Animals; D001345:Autoradiography; D002369:Castration; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D011960:Receptors, Estrogen; D012737:Sex Factors
D004273:DNA, Neoplasm; D011960:Receptors, Estrogen