Experimental investigations on the influence upon the chemical carcinogenesis. IIIrd communication: studies with 1,2-dimethylhydrazine.
After ten times monthly, subcutaneous, injections of 30 mg/kg 1,2-dimethylhydrazine (DMH) to Sprague-Dawley-rats, malignant tumors were found in approximately 90% of the animals after a mean induction period of approximately 330 days. Injections were started on the 2nd day of life and maintained during 10 months. 72% of the tumors induced were formed in the colon, 17% were squamous cell carcinomas of the ear duct, adenosarcomas of the kidney and hepatocellular carcinomas were found in 13 and 11% of the animals, respectively. Additional treatment with immunodepressive (cyclophosphamide, methotrexat, hydrocortisone) and immunostimulating substances (BCG, albumin, vitamin A-acid) as well as an enzyme-stimulating agent (Luminal) did not alter incidences and induction periods of tumors. After application of a vegetarian diet, the rate of liver and kidney tumors was diminished significantly and induction periods of intestinal and ear duct tumors increased.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D004032:Diet; D004127:Dimethylhydrazines / Q000494:pharmacology*; D004428:Ear Neoplasms / Q000139:chemically induced; D005260:Female; D006834:Hydrazines / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012709:Serum Albumin / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology
D001500:BCG Vaccine; D004127:Dimethylhydrazines; D006834:Hydrazines; D007166:Immunosuppressive Agents; D012709:Serum Albumin; D014212:Tretinoin; D010634:Phenobarbital