title: Fatty acid synthesis in vitro in the liver and adipose tissue of rats of various ages.
abstract: In white male Wistar rats aged 2, 4, 6, 9, 12, 18 and 32 months, receiving a standard laboratory diet (25 cal% proteins, 22 cal% fat and 53 cal% glycides) we assessed the total amount of fatty acids in the carcass and in vitro lipogenesis in liver and adipose tissue by the means of glucose-14C(U). The amount of body fat increased with age; the highest rate of increase in the percentage of body fat occurs 2 to 4 months after birth. Incorporation of 14C of glucose into total liver lipids attains maximum values in the group of rats age 2 to 4 months. By the age of 6 months lipogenesis decreased to a level observed in all the remaining age groups. In adipose tissue, the incorporation of 14C into total lipids decreased between the age of 2 to 4 months, a further decrease was observed around the age of 6 months. No appreciable changes were noted in any of the older age groups.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D002250:Carbon Radioisotopes; D004822:Epididymis / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D002250:Carbon Radioisotopes; D005227:Fatty Acids