[Effects of the cis-dichloro-diammino-platinum(II)-deoxyribonucleic acid on normal and cancerous cells].
The effects of cis-dichloro-diammino-platinum(II) (cis-Pt) bound to DNA have been compared to those of free cis-Pt in mouse Ehrlich tumour cells, in peritoneal macrophages and in chick embryo fibroblasts cultivated in vitro. Cis-Pt has no antimitotic activity anymore when linked to DNA. This would be due to the fact that free cis-Pt is not released from cis-Pt-DNA complex inside lysosomes.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects; D051379:Mice
D004247:DNA; D002945:Cisplatin
Effets du complexe cis-dichloro-diammino-platine(II)-acide désoxyribonucléque sur des cellules normales ou cancéreuses