title: Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform.
abstract: Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration of phenylephrine, a directly acting alpha-adrenergic agonist, with  chlordimeform did not increase the lethality of chlordimeform. Thus, monoamine oxidase inhibition by chlordimeform does not seem to contribute to its lethality.
mesh_terms: D000578:Amidines / Q000506:poisoning*; D000818:Animals; D001522:Behavior, Animal; D002742:Chlorphenamidine / Q000506:poisoning* / Q000633:toxicity; D010134:Fenclonine / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000506:poisoning*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats
chemical_list: D000578:Amidines; D008781:Methyltyrosines; D008996:Monoamine Oxidase Inhibitors; D010656:Phenylephrine; D002742:Chlorphenamidine; D010134:Fenclonine