[Effect of stimulation of the hypothalamic nuclei on the lipid concentration and ATPase activity of the mitochondrial and microsomal fractions of the rabbit heart].
Stimulation of the ventro-medial nuclei of the hypothalamus led to reduction in the concentration of phospholipids, triglycerides, and cholesterol in the mitochondria of the rabbit heart. Cholesterol load against this background elevated the concentration of cholesterol and reduced the phospholipid concentration even more. The heart mitochondrial and microsomal activity of Ca2+--ATP-ase was reduced. These data differed from the results recieved in the action of cholesterol alone. The research carried out showed that the action of exogenous cholesterol depended on the mechanisms regulating the lipid metabolism.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002118:Calcium; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004558:Electric Stimulation; D004789:Enzyme Activation; D006321:Heart / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000502:physiology; D050356:Lipid Metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits
D002791:Cholesterol, Dietary; D000251:Adenosine Triphosphatases; D002118:Calcium
Vliianie razdrazheniia iader gipotalamusa na kontsentratsiiu lipidov i ATF-aznuiu aktivnost' mitokhondrial'noĭ i mikrosomal'noĭ fraktsii serdtsa krolikov.