Metabolism of nitrosamines in vivo. V Investigation on 14CO2 exhalation, liver RNA labelling and isolation of two metabolites from urine after administration of [2, 5-14C-]dinitrosopiperazine to rats.
The synthesis of N, N'-dinitrosopiperazine and N-nitrosopiperazine, both 14C-labelled in the 2-and 5-position is described. After i.p. application of 10 mg/69.5 muCi/kg[2, 5-14C]-N, N'-dinitrosopiperazine to rats no labelled 7-methylguanine was detected in the liver RNA; 1% of the radioactivity was exhaled as 14CO2, 1% excreted via the bile and about 40% excreted in the urine. Two of the urine metabolites were identified as 3-hydroxynitrosopyrrolidine and 1-nitrosopiperazinone-(3).
D000818:Animals; D001646:Bile / Q000378:metabolism; D006147:Guanine / Q000031:analogs & derivatives; D008099:Liver / Q000378:metabolism; D008745:Methylation; D009602:Nitrosamines / Q000378:metabolism*; D009603:Nitroso Compounds / Q000138:chemical synthesis / Q000378:metabolism*; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis / Q000378:metabolism*; D011759:Pyrrolidines / Q000652:urine; D012313:RNA / Q000378:metabolism; D051381:Rats
D009602:Nitrosamines; D009603:Nitroso Compounds; D010879:Piperazines; D011759:Pyrrolidines; D006147:Guanine; D012313:RNA