Erythroderma, an unusual manifestation of B cell lymphoma.
A case is described in which the initial manifestation of a malignant lymphoma was an erythematous skin rash over the face, scalp and trunk. Immunological surface marker analysis showed the malignant cells to be of B lymphocyte origin with a homogeneous secretion of IgM-K. Repeated skin and lymph node biopsies and finally post mortem documented the progression of the lymphoma from that of a mixed lymphocytic-histiocytic type with a nodular pattern of growth to a diffuse histiocytic lymphoma with frequently bizarre cells. The theory of ecotaxis or homing of lymphocytes to the skin and other non-lymphoid organs of the body is discussed in an attempt to explain the occurrence of cutaneous involvement as a primary manifestation of lymphoma.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D003873:Dermatitis, Exfoliative / Q000209:etiology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008223:Lymphoma / Q000150:complications* / Q000473:pathology; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012867:Skin / Q000473:pathology
D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell