[Effect of methaqualone on the respiration, phosphorylation and ATPase activity of rat brain mitochondria].
The authors examined the influence of the preparation metaqualone on some aspects of adrenergic metabolism-respiration, phosphorilation and ATP-ase activity of brain mitochondria of a rat in order to discover pharmacobiochemical mechanism of action. The experimental data showed that administration of metaqualon in a dose of 70 mg per kg of body weight intraperitonealy, induced a lowering of phosphorilating activity in a substrate succinate. This fact gave a foundation to suppose that in shorted respiratory chain the effect of metaqualone on the aerobic resynthesis of ATP was at a level succinat-dehydrogenase complexes. Metaqulaon induced changes in the energetic metabolism, influencing mainly of the mechanisms of the synthesis of ATP without substantial effect on the electrone transport.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D008297:Male; D008702:Methaqualone / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D008702:Methaqualone; D000251:Adenosine Triphosphatases
Vliianie na metakvalona vurkhu dishaneto, fosforiliraneto i ATF-aznata aktivnost na mozuchni mitokhondrii ot plukh.