Using the HmL1 strain of Histomonas meleagridis in evaluating chemotherapeutants in chicks.
Ten-day-old White Leghorn cockerels were inoculated per cloaca with 500,000 culture forms of the HmL1 strain of Histomonas meleagridis. Birds dying on the 6th and 7th days and birds necropsied 7 days postinoculation had prominent cecal and liver lesions indicative of severe histomoniasis. Dose responses were obtained with three 1,2-disubstituted 5-nitroimidazoles blended into the feed at various concentrations, demonstrating the utility of this virulent strain in chemotherapy studies.
D000818:Animals; D002432:Cecum / Q000473:pathology; D002645:Chickens; D004341:Drug Evaluation; D056890:Eukaryota / Q000472:pathogenicity*; D008099:Liver / Q000473:pathology; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use; D011528:Protozoan Infections / Q000188:drug therapy* / Q000473:pathology; D013047:Specific Pathogen-Free Organisms
D009593:Nitroimidazoles