The Sézary syndrome. A case with fetal-type glycogen and lymphocytic lymphoma.
A patient had Sézary syndrome and lymphocytic lymphoma. Cytoplasmic inclusions within the Sézary cells were demonstrated by histochemistry and electron microscopy to be composed of fetal-type glycogen. Results of tests for the presence of virus were negative. It is suggested that the Sézary cell represents a reversion of metabolic systems to more youthful types. Previously reported differences in diastase reactivity of the PAS-positive cytoplasmic inclusions are probably based on whether the glycogen is in fetal or mature configuration.
D002699:Chlorambucil / Q000627:therapeutic use; D003594:Cytoplasmic Granules / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D003873:Dermatitis, Exfoliative / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome; D014750:Vincristine / Q000627:therapeutic use
D002699:Chlorambucil; D014750:Vincristine; D006003:Glycogen; D011241:Prednisone