Biology of the granulocyte chalone.
Granulocyte chalone is a cell line-specific, species non-specific regulator substance, which inhibits cell proliferation in the granulocyte system in a reversible manner. The existence and specificity of action of this substance has been shown both in vitro and in vivo in widely different assay conditions and using a broad spectrum of assay techniques. Granulocyte chalone inhibits cell proliferation in the transit populations of the granulocyte system; it seems to act at the level of cell membrane and divert cells from the G1 phase to the "G0" phase with some direct or indirect effect on S phase cells as well. The substance is non-cytotoxic and it has no detectable effect on any other tissue than normal and leukaemic granulocytes even after long-lasting in vivo treatment. Granulocyte chalone offers an exciting potential for the treatment of myeloid leukaemia and, therefore, the substance is of more than academic interest.
D002462:Cell Membrane / Q000378:metabolism; D002875:Chromosomes / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006098:Granulocytes / Q000032:analysis*; D006131:Growth Inhibitors / Q000502:physiology* / Q000633:toxicity; D006801:Humans; D007621:Karyotyping; D007962:Leukocytes / Q000032:analysis*; D008938:Mitosis / Q000187:drug effects
D006131:Growth Inhibitors; D004247:DNA