A reproducible model of moderate to severe concentric left ventricular hypertrophy.
A reproducible model for the production of moderate to severe concentric left ventricular hypertrophy has been developed in this laboratory. Coarctation-banding of the ascending aorta was performed successfully in 10 puppies. There were no late deaths related to aortic rupture, and in the dogs surviving for 1 yr no evidence of congestive heart failure was present. A second operative procedure was performed in seven dogs for chronic instrumentation, and all survived. Severe supravalvular aortic stenosis with a marked peak systolic pressure gradient was noted in each dog. Postmortem examination revealed a substantial increase in left ventricular mass and in the ratio of left ventricular to body weight.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001017:Aortic Coarctation / Q000473:pathology / Q000503:physiopathology; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology*; D003250:Constriction; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics