title: Site of hydrolysis of collagen by hot trichloroacetic acid.
abstract: When calfskin collagen is treated with trichloroacetic acid at 90 degrees C, it is hydrolyzed to a mixture of peptides, some of which are quite small. Cleavage of collagen by acid seems to occur at bonds between proline (or hydroxyproline) and other amino acids, with only a limited specificity for which amino acid donates its amino group to the susceptible peptide bond.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002417:Cattle; D003094:Collagen; D006358:Hot Temperature; D006868:Hydrolysis; D006909:Hydroxyproline / Q000032:analysis; D010455:Peptides / Q000032:analysis; D011392:Proline / Q000032:analysis; D014238:Trichloroacetic Acid
chemical_list: D000596:Amino Acids; D010455:Peptides; D014238:Trichloroacetic Acid; D003094:Collagen; D011392:Proline; D006909:Hydroxyproline