Mechanisms of immune deposition in relation to a loosened molecular structure of acid mucopolysaccharides (aMP) caused by a low calcium diet--with special regard to their negative charges.
Diets used for breeding guinea pigs usually require 1.3--1.5% calcium. In the previous paper, guinea pigs bred on a low calcium diet of 0.2% for 4--6 weeks, showed mesangiolytic changes in the glomerulus. In this experiment, after breeding guinea pigs on a low calcium diet, soluble immune complexes which have positive charges in their structure, were injected once intravenously. By electron microscopy an increased amount of deposits in the basement membrane, in the subepithelial side of it, and in the mesangial matrix where they were loosened by a low calcium diet breeding, as reported in the previous paper, was noted. In this paper, mechanisms of immune deposition in relation to a loosened molecular structure of acid mucopolysaccharides, caused by a low calcium diet--especially their negative charges--will be discussed.
D000818:Animals; D000936:Antigen-Antibody Complex; D001485:Basement Membrane / Q000473:pathology; D002118:Calcium / Q000172:deficiency*; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006168:Guinea Pigs; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D051381:Rats
D000936:Antigen-Antibody Complex; D006025:Glycosaminoglycans; D002118:Calcium