[Results of intramuscular injection of glycosamino-glycanpolysulfate (GAGPS) in experimental arthrosis of the knee in dogs (author's transl)].
Report on the action of GAGPS injected intramuscularly on experimental arthrosis of the knee-joint in dogs. In both hind-legs the lateral tibial joint-surface and the lateral meniscus were resected. This produces arthrotic changes similar to human arthrosis within 2 months. Of 27 dogs 13 received i.m. injections into the glutei of GAGPS (25 mg/kg). 14 dogs were not untreated controls. After the 7th postoperative day the injections were given on every third day on 10 occasions, thereafter every fourth day for another 10 occasions. The animals were killed 3 months after the start of the experiment. Loss of cartilage on the lateral condyle proved to be clearly less pronounced in the treated animals than in the controls, macroscopically, radiologically and histolocally. GAGPS, injected, intragluteally, limits loss of cartilage in experimental arthrosis of the knee in dogs.
D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects / Q000473:pathology; D004285:Dogs; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D007719:Knee Joint; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D006025:Glycosaminoglycans
Ergebnisse der intramuskulären Glykosaminoglykanpolysulfat-(GAGPS-) Applikation bei der experimentellen Kniegelenkarthrose des Hundes