Life-threatening enterocolitis after gold salt therapy.
Two patients developed life-threatening enterocolitis after receiving gold salt therapy. This disorder is attended by a mortality rate of 50% but the intestinal lesion appears to be reversible. The mechanism of the drug toxicity is not known. The course may be fulminant and recovery may occur only after many weeks. Total bowel rest, nasogastric suction, total parenteral nutrition with supplemental colloid and careful monitoring of fluid and electrolyte balance may improve survival.
D000328:Adult; D000368:Aged; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006046:Gold / Q000009:adverse effects*; D006052:Gold Sodium Thiomalate / Q000009:adverse effects*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D010289:Parenteral Nutrition, Total
D006052:Gold Sodium Thiomalate; D006046:Gold