title: Reconstruction of the canine Achilles and patellar tendons using dacron mesh silicone prosthesis. I. Clinical and biocompatibility evaluation.
abstract: Surgical replacement of the Achilles and patellar tendons using Dacron mesh silicone prostheses was performed in 15 mature beagle dogs. This part of the study includes clinical evaluation, gross inspection at autopsy of regrown tendons, and histological determination of biocompatibility of prosthetic implants. Functional continuity and integrity of prosthetic patellar tendons have been established by evaluating the biologic-prosthetic interface and the mechanical properties of regrown tendon tissue around and through the Dacron silicone replacements. Results of prosthetic Achilles tendons were less satisfactory because of difficulties in suturing to a muscle and its fascia. Although the prosthetic tendon did not regrow through the tube, it provided a structure for regrowth around it. The regrown tendons became nearly ten times the normal cross-sectional area after three to four months and decreased to two to three times after 13 months. Histological studies indicate that in the absence of infection, the Dacron mesh silicone tendon was well tolerated for periods up to 13 months. Overall results are encouraging and warrant further investigation although the regenerative capacity of human patellar and Achilles tendons is unknown.
mesh_terms: D000125:Achilles Tendon / Q000033:anatomy & histology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology; D004285:Dogs; D010329:Patella / Q000601:surgery*; D011093:Polyethylene Terephthalates; D019736:Prostheses and Implants; D012825:Silicon; D013526:Surgical Mesh; D013710:Tendons / Q000033:anatomy & histology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D003094:Collagen; D012825:Silicon