[Fibrinolytic activity of blood flowing through the heart ventricles and major vessels of rats under normal conditions and in experimental myocardial ischemia].
Sampling blood from the jugular, superior and inferior caval veins and the pulmonary artery and the heart ventricles of intact rats revealed that the fibrinolytic activity was the lowest in the jugular vein, while it was 1.5-2 times higher in the other sections. The fibrinolysis in these animals is 1.5 times higher in the right ventricle than in the left. One day after coronary artery ligation a reverse relationship is observed: the blood in the left ventricle has a 1.5-times higher fubinolytic activity than that in the right. The difference in the activity is due to a different plaminogen activator content. Three days after the onset of myocardium ischaemia the difference in the fibrinolytic activity of the blood in both ventricles disappears. The obtained data emphasize the role of local fibrinolysis in the development of cardiac pathology.
D000818:Animals; D001780:Blood Coagulation Tests; D003327:Coronary Disease / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D005342:Fibrinolysis; D005343:Fibrinolytic Agents; D006352:Heart Ventricles; D007601:Jugular Veins; D008297:Male; D010960:Plasminogen Activators / Q000097:blood; D011651:Pulmonary Artery; D051381:Rats; D014684:Venae Cavae
D005343:Fibrinolytic Agents; D005340:Fibrinogen; D010960:Plasminogen Activators; D005341:Fibrinolysin
Fibrinoliticheskaia aktivnost' krovi, protekaiushcheĭ v zheludochkakh serdtsa i krupnykh sosudakh krys v norme i pri eksperimental'noĭ ishemii miokarda.