Alloimmune anti-H-2 mouse sera inhibit human mixed lymphocyte reactions.
The inhibitory effect of alloimmune congenic mouse anti-H-2f serum on human mixed lymphocyte cultures was investigated. The anti-H-2 serum tested produced a strong inhibitory effect on human allogeneic MLR. This effect was more pronounced when HLA-A2 positive cells were involved in the MLR. More experiments are needed to substantiate the finding that both stimulator and responder functions of the human lymphocytes are impaired. The anti-H-2 serum also inhibited the human lymphocyte response to PHA.
D000818:Animals; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000302:isolation & purification; D006801:Humans; D007106:Immune Sera; D037102:Lectins; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice
D006680:HLA Antigens; D007106:Immune Sera; D037102:Lectins