Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method.
Blockade of tonic hindlimb extension (THE) in the maximal electroshock seizure test was demonstrated for C-28'882-Ba, a muscle spindle suppressant, chlorpromazine, a depressant of fusimotor drive, and gallamine, a neuromuscular blocking drug. These agents also blocked THE produced by very large doses of pentylenetetrazol. Dantrolene, a muscle contraction antagonist, and MI-65-S, a muscle spindle suppressant, significantly delayed THE. The data indicate that blockade of THE may be effected at a multiplicity of loci and may not be an expression of an "anticonvulsant" effect.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003620:Dantrolene / Q000494:pharmacology; D004597:Electroshock; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006614:Hindlimb; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009470:Muscle Spindles / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects*; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced
D000927:Anticonvulsants; D003620:Dantrolene; D005703:Gallamine Triethiodide; D002746:Chlorpromazine; D010433:Pentylenetetrazole