Histochemical changes of the rat testis and epididymis after treatment of alpha-chlorohydrin-effects of a single low dose.
A histochemical study has been made of the localization and changes of lipids, carbohydrates, ATPase and 5'-nucleotidase in fresh and fixed frozen sections of testicular and epididymal components in the normal and alpha-chlorohydrin-treated rats. After treatment with a single low dose of alpha-chlorohydrin, the phospholipids are decreased with corresponding increase in triglycerides in both the testis and epididymis. Glycogen, ATPase and 5'-nucleotidase are also decreased after treatment with alpha-chlorohydrin. The physiological significance of these histochemical changes has been discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D002728:Chlorohydrins / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D006651:Histocytochemistry; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D000517:alpha-Chlorohydrin; D000251:Adenosine Triphosphatases