title: Critical tests of suspension, paste, and pellet formulations of cambendazole in the horse.
abstract: Three formulations of cambendazole were evaluated for anthelmintic activity by critical testing method in 21 horses. Cambendazole suspension was administered via stomach tube at the dose rate of 10 mg/kg to 3 horses and at the dose rate of 20 mg/kg to 3 horses. Cambendazole paste was given intraorally to 8 horses, and the pellet formulation was fed to 7 horses at the dose rate of 20 mg/kg. Anthelmintic activity of cambendazole was similar for all dose rates and formulations. Gasterophilus intestinalis, Gasterophilus nasalis, Draschia megastoma, Anoplocephala perfoliata, and Anoplocephala magna appeared to be refractory. The 3 formulations removed (1) 100% of Parascaris equorum and mature Oxyuris equi, (2) 82 to 100% of Strongylus vulgaris, (3) 80 to 100% of Strongylus edentatus, (4) 85 to 99% of small strongyles, and (5) 79 to 100% of immature Oxyuris equi. Probstmayria vivipara was present in only 1 horse and removal was 99%. There was some evidence of activity on Habronema muscae. Toxicosis was not observed.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D002159:Cambendazole / Q000627:therapeutic use; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary; D004304:Dosage Forms; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D009198:Myiasis / Q000188:drug therapy / Q000662:veterinary; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D010123:Oxyuriasis / Q000188:drug therapy / Q000662:veterinary; D010273:Parasitic Diseases, Animal; D017205:Spirurida Infections / Q000188:drug therapy; D013319:Strongyle Infections, Equine / Q000188:drug therapy; D013535:Suspensions / Q000008:administration & dosage*
chemical_list: D000871:Anthelmintics; D004304:Dosage Forms; D013535:Suspensions; D002159:Cambendazole