X monosomy and 21 trisomy in a sibship.
The case of a sibship of 4, 2 members of which present aneuploïdy (45,X and 47,XX,21+) is reported.  The paternal grandfather and grandmother are first cousins and there is a large number of centromeric associations in the father.
D000293:Adolescent; D000782:Aneuploidy; D003241:Consanguinity; D003878:Dermatoglyphics; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D010375:Pedigree; D012730:Sex Chromosomes