Is the diabetogenic effect of streptozotocin in part thymus-dependent?
Following a single injection of 200 mg streptozotocin/kg BW, 25 out of 25 normal mice became diabetic, whereas 12 ( = 20%) out of 50 athymic nude mice did not develop diabetes. In a multiple dosage experiment, where the same total dose was given over a 5 days period, 14 normal and 15 athymic nude mice all became diabetic, but nude mice had significantly lower blood glucose values. These results support our previous suggestion that a thymus dependent immune reaction is, in part, responsible for the diabetogenic effect of streptozotocin.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007111:Immunity, Cellular; D007274:Injections, Intraperitoneal; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D013311:Streptozocin / Q000008:administration & dosage; D013950:Thymus Gland / Q000502:physiology*
D001786:Blood Glucose; D013311:Streptozocin