Studies on niacin biosynthesis from 3-hydroxyanthranilic acid in streptozotocin diabetic rats in vivo and in vitro.
Biosynthesis of niacin from 3-hydroxyanthranilic acid (3-OHAA) in normal and streptozotocin diabetic rats was studied in vivo and in vitro. Streptozotocin (SZ) diabetic rats were found to excrete lesser quantities of 3-OHAA, quinolinic acid, niacin and N1-methylnicotinamide (nmn) in their urines following 3-OHAA administration than corresponding normal rats. In vitro studies indicated that SZ diabetic livers form less quinolinic acid from 3-OHAA than normal livers. It appears that this may be due to elevated picolinic carboxylase activity in the livers of SZ diabetic rats.
D015095:3-Hydroxyanthranilic Acid / Q000378:metabolism*; D000818:Animals; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009539:Nicotinic Acids / Q000096:biosynthesis / Q000378:metabolism*; D011805:Quinolinic Acids / Q000378:metabolism; D051381:Rats; D013311:Streptozocin; D062367:ortho-Aminobenzoates / Q000378:metabolism*
D009539:Nicotinic Acids; D011805:Quinolinic Acids; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; D013311:Streptozocin