Glomerular ultrastructural abnormalities in a patient with mixed IgG-IgM essential cryoglobulinemic glomerulonephritis.
Distinct glomerular ultrastructural lesions in the form of nodular subepithelial and intramembranous, as well as discrete and band-like subendothelial deposits are described in a patient suffering from mixed IgG-IgM essential cyoglobulinemic glomerulonephritis. It is suggested that the deposits may represent immune complexes which are belived to play a central role in the pathogenesis of the glomerulonephritis.
D000328:Adult; D001706:Biopsy; D003450:Cryoglobulins / Q000302:isolation & purification*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications; D007074:Immunoglobulin G / Q000302:isolation & purification*; D007075:Immunoglobulin M / Q000302:isolation & purification*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D012217:Rheumatoid Factor / Q000302:isolation & purification
D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor