Changes in erythrocyte membrane ouabain-sensitive adenosine triphosphatase after renal transplantation.
1. Intracellular electrolytes, and erythrocyte membrane adenosine triphosphatase (ATPase) activity, was studied in twenty patients after renal transplantation. 2. The mean ouabain-sensitive ATPase activity in the erythrocyte membranes of the transplant patients was 122 nmol of inorganic phosphorus (Pi) h-1 mg of tissue-1 (SEM 14), compared with 62 nmol of Pi h-1 mg of tissue-1 (SEM 8) in a group of paired, healthy controls. 3. The increase in ouabain-sensitive ATPase was most marked in the 4 months after transplantation. However, a significant increase in ouabain-sensitive ATPase persisted for more than 8 months after transplantation. 4. This increase in ouabain-sensitive ATPase was associated with a decrease in intracellular sodium in the erythrocytes of the transplant patients.
D000251:Adenosine Triphosphatases / Q000097:blood*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation; D010042:Ouabain / Q000494:pharmacology*; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D010042:Ouabain; D000251:Adenosine Triphosphatases