[A comparison of osteotropic radiopharmaceuticals. II. Plasma clearance of 18F and 99mTc-EHDP (author's transl)].
Renal and extra-renal clearance of 18F and 99mTc-EHDP were compared in the same individuals. The 18F space is twice that of 99mTc-EHDP, as is its renal clearance. 99mTc undergoes glomerular filtration, 18F is excreted by glomerular filtration and tubular secretion. Extraction rate was determined indirectly by a comparison with extra-renal clearance, and for patients without bone disease it was four times as high for 18F as it was for 99mTc-EHDP. In patients with secondary hyperparathyroidism extra-renal clearance is greatly increased. This is explained by an increased extraction rate, which may be different for the two substances.
D001847:Bone Diseases / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002857:Chromium / Q000378:metabolism; D002860:Chromium Radioisotopes / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004492:Edetic Acid / Q000378:metabolism; D012968:Etidronic Acid / Q000378:metabolism*; D005459:Fluorides / Q000097:blood / Q000378:metabolism*; D005919:Glomerular Filtration Rate; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D008657:Metabolic Clearance Rate; D009943:Organophosphorus Compounds / Q000378:metabolism*; D011877:Radionuclide Imaging; D013667:Technetium / Q000097:blood / Q000378:metabolism*
D002860:Chromium Radioisotopes; D009943:Organophosphorus Compounds; D002857:Chromium; D013667:Technetium; D004492:Edetic Acid; D003404:Creatinine; D012968:Etidronic Acid; D005459:Fluorides
Vergleichende Untersuchungen mit osteotropen Radiopharmaka. II. Plasmaclearance von 18F und 99mTc-EHDP