Changes with age in the occurrence of C19 steroids in the testis and submaxillary gland of the boar.
After extraction from the testes of boars of different ages, C19 steroids including 16-androstenes were determined by gas-liquid chromatography. Similarly, 16-androstenes were determined in the submaxillary glands of these boars. A high concentration of testosterone was found in the testes of 84-day-old fetuses, and this might be significant in the differentiation of male behaviour. The amount of testosterone exceeded that of androstenedione during postnatal development, and dehydroepiandrosterone and 5-androstenediol as free and sulphates were found in high concentrations particularly in postpubertal boars, suggesting that the 5-ene pathway for the synthesis of testosterone might be important. There was a change in the predominance of individual 16-androstenes in the testis during development, which closely paralleled the sequence for the biosynthesis of these compounds proposed from previous studies in vitro. Whereas the amount of 5alpha-androst-16-en-3beta-ol exceeded that of 5alpha-androst-16-en-3alpha-ol in post-pubertal testes, 5alpha-androst-16-en-3alpha-ol was predominant in the submaxillary glands at all ages. The high concentration of 16-androstenes found in the mature boar, are discussed in relation to their release as pheromones and as factors responsible for taint in boar meat.
D000367:Age Factors; D000734:Androstenediols / Q000032:analysis; D000735:Androstenedione / Q000032:analysis; D000736:Androstenes / Q000032:analysis*; D000737:Androstenols / Q000032:analysis; D000818:Animals; D002849:Chromatography, Gas; D003687:Dehydroepiandrosterone / Q000032:analysis; D005260:Female; D005333:Fetus; D007246:Infertility; D007985:Leydig Cells / Q000166:cytology; D008297:Male; D009929:Organ Size; D013363:Submandibular Gland / Q000032:analysis* / Q000254:growth & development; D013552:Swine / Q000254:growth & development*; D013737:Testis / Q000032:analysis* / Q000166:cytology / Q000254:growth & development; D013739:Testosterone / Q000032:analysis
D000734:Androstenediols; D000736:Androstenes; D000737:Androstenols; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone