[Effect of erythrocytic G2-chalone on the erythrokinetics in mice].
It was shown that erythrocytic inhibitor (G2-cheilon) acted both on the proliferating and on differentiated cells of the erythroid series of the mouse bone marrow. The effect of cheilon was expressbd as soon as 3 hours after its administration and lasted for from 8 to 48 hours, depending on the extent of cell differentiation. In case of a single cheilon administration, despite significant erythropoiesis disturbances, erythrocyte count determined 8 to 12 days later persists within the control level. Repeated administration of cheilon was accompanied by a fall of the erythrocyte count at later periods of the experiment.
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D004905:Erythrocyte Aging / Q000187:drug effects*; D004906:Erythrocyte Count; D004912:Erythrocytes; D004920:Erythropoiesis / Q000187:drug effects*; D006131:Growth Inhibitors / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D013997:Time Factors
D006131:Growth Inhibitors
Vliianie éritrotsitarnogo G2-keĭlona na éritrokinetiku u mysheĭ.