title: The embryology and surgical management of gastroschisis.
abstract: Thirteen cases of gastroschisis are presented and a reduction in the operative mortality to 15 per cent is recorded. The aetiology of the condition is discussed and the opinion expressed that it represents the result of an intra-uterine rupture of an incarcerated "hernia into the cord" rather than any specific failure of development of the abdominal wall musculature. Early skin closure and the creation of a ventral hernia remain the surgical treatment of choice, but it is recognized that the use of a prosthetic sac may occasionally be necessary. Infection is not the most important single factor influencing mortality, and the prolonged administration of prophylactic antibiotics is justified on this basis. Skilled management of the protracted ileus is essential. In view of the low incidence of serious coexistent malformations the children who survive the initial operation can be offered the prospect of a life of normal duration and quality.
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities* / Q000196:embryology / Q000601:surgery; D004065:Digestive System Abnormalities; D005260:Female; D005500:Follow-Up Studies; D006555:Hernia, Ventral / Q000150:complications / Q000196:embryology / Q000601:surgery; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000209:etiology; D008297:Male; D011183:Postoperative Complications; D013530:Surgical Wound Infection / Q000517:prevention & control