Hyaluronate-proteoglycan complex: evidence for separate biosynthesis mechanisms of the macromolecules.
In cartilage cells biosynthesis of hyaluronate and chondroitin-4-,-6-sulfate from proteoglycan takes place via two different distinct precursor pools; the synthesis of hyaluronate appears to require the unaffected formation of nucleotides and nucleic acids, whereas that of proteoglycan is very sensitive to the modulation of protein biosynthesis.
D000818:Animals; D002356:Cartilage / Q000378:metabolism*; D002417:Cattle; D002809:Chondroitin Sulfates / Q000096:biosynthesis; D046508:Culture Techniques; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003980:Diazooxonorleucine / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000096:biosynthesis*; D010653:Phenylbutazone / Q000494:pharmacology; D011509:Proteoglycans / Q000096:biosynthesis*; D011691:Puromycin / Q000494:pharmacology; D012272:Ribs; D012643:Selenium / Q000494:pharmacology
D011509:Proteoglycans; D003980:Diazooxonorleucine; D003609:Dactinomycin; D011691:Puromycin; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D003513:Cycloheximide; D010653:Phenylbutazone; D012643:Selenium