[Effect of schizophyllan on delayed hypersensitivity in the mouse (author's transl)].
The delayed cutaneous hypersensitivity test with picryl chloride was used to demonstrate the effect of sonicated schizophyllan (SPG-S) on cellular immunity in mice. The increase of ear thickness in mice treated with SPG-S (0.5 approximately 10.0 mg/kg) 24 hours before the sensitization with picryl chloride proved to be significantly larger than that in untreated mice on testing with picryl chloride at 7 days following sensitization. Mice were intramuscularly injected with SPG-S (5.0 mg/kg) on -48, -24, 0, +24 or +48 hours of sensitization. Remarkable stimulating effect of SPG-S on the delayed hypersensitivity was recognized in all groups of mice, being somewhat lower in the group treated with SPG-S 48 hours after the sensitization. Stimulating effects of lipopolysaccharide, concanavalin A, pokeweed mitogen and SPG-S on the delayed hypersensitivity were compared. The effect of SPG-S was similar to that of concanavalin A, a nonspecific stimulant for T cells.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D010853:Picryl Chloride / Q000276:immunology; D012566:Sizofiran / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D006025:Glycosaminoglycans; D008070:Lipopolysaccharides; D008934:Mitogens; D003208:Concanavalin A; D012566:Sizofiran; D010853:Picryl Chloride