[Modality of the antimitotic acitivity of the diamine cis-dichloroplatinum (II) studied on the plant cell].
In the order of decreasing doses, cis-platinum (II) diamine dichloride acting on root meristem of Allium sativum produces first an irreversible metostatic effect quickly followed by lethal effect, then a variable mitodepression accompanied by important chromosomal alterations: numerous disruptions and stickiness. This chromatoclasic effect persists at very low concentrations but stathmodieretic effect is not observed. The chromatoclasic activity of the compound is compared to that of other antitumoral drugs.
D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005737:Garlic / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects*; D010946:Plants, Medicinal; D013997:Time Factors
D002945:Cisplatin
Modalités de l'activité antimitotique du cis-dichloro diammine platine (ii) étudiées sur la cellule végétale