Effects of serotonergic drugs on methaqualone-induced hypothermia.
Methaqualone (75 mg/kg) produced a significant decrease in the rectal temperature of mice. This effect was antagonized by parachlorophenylalanine and potentiated by Lilly 110140. These compounds also decreased and increased respectively the circulating concentration of methaqualone.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008702:Methaqualone / Q000097:blood / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010647:Phenyl Ethers / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D010647:Phenyl Ethers; D011437:Propylamines; D011985:Receptors, Serotonin; D012701:Serotonin; D008702:Methaqualone; D010134:Fenclonine