Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of brain 5-hydroxytryptamine in the anorectic activity of fenfluramine.
As it is well-known, fenfluramine produces anorexia and decrease in brain 5-hydroxytryptamine (5-HT). As it has been suggested that the anorectic effect of fenfluramine may be due to a release of brain 5-HT, we have examined the influence of several drugs active on 5-HT mechanisms and metabolism, on the anorexigenic activity of fenfluramine. These studies were made in relationship with the depletion of 5-HT levels and the concentration of brain fenfluramine or m-trifluoromethyl-isopropylamine. The results have confirmed the involvement of a tryptaminergic mechanism in fenfluramine anorexia and suggest the hypothesis that fenfluramine itself can interfere with the serotoninergic system in the brain (stimulation of tryptaminergic neurons directly).
D000577:Amides / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D005277:Fenfluramine / Q000097:blood / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009642:Norfenfluramine / Q000097:blood / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism* / Q000502:physiology; D013687:Telencephalon / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014439:Tyramine / Q000031:analogs & derivatives; D010133:p-Chloroamphetamine / Q000494:pharmacology
D000577:Amides; D001067:Appetite Depressants; D009642:Norfenfluramine; D005277:Fenfluramine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010133:p-Chloroamphetamine; D002997:Clomipramine; D010134:Fenclonine; D014439:Tyramine