A study of connective tissue macromolecules in skin of mice with goldthioglucose-induced obesity.
The effect of obesity on the connective tissue composition of skin was investigated in mice with goldthioglucose (GTG)-induced obesity.  Four months after GTG treatment, the obese animals were sacrificed.  Acid mucopolysaccharides, glycoproteins, collagen, and elastin were analyzed in the skin and compared to the controls.  Total MPS in the skin from obese animals decreased, reflected mostly in hyaluronic acid.  Chondroitin showed an increase over controls.  The content of soluble glycoproteins varied; total carbohydrate and sialic acid of the glycoprotein tended to increase with obesity.  Collagen and elastin both tended to decrease with obesity.
D000818:Animals; D006051:Aurothioglucose; D002241:Carbohydrates / Q000032:analysis; D005591:Chemical Fractionation; D002845:Chromatography; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000473:pathology*; D004549:Elastin / Q000032:analysis; D004586:Electrophoresis; D006023:Glycoproteins / Q000032:analysis / Q000302:isolation & purification; D006025:Glycosaminoglycans / Q000032:analysis / Q000302:isolation & purification; D006046:Gold; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D009765:Obesity / Q000139:chemically induced / Q000473:pathology*; D009929:Organ Size; D012867:Skin / Q000032:analysis / Q000473:pathology*; D013997:Time Factors
D002241:Carbohydrates; D006023:Glycoproteins; D006025:Glycosaminoglycans; D046911:Macromolecular Substances; D006051:Aurothioglucose; D006046:Gold; D003094:Collagen; D004549:Elastin