title: Parenteral immunization of pigs against infection with Treponema hyodysenteriae.
abstract: Six intravenous injections of formalin-inactivated Treponema hyodysenteriae were given to 8 specific-pathogen-free pigs at 6-day intervals. The 8 vaccinated and 8 control pigs were challenged intragastrically with pure cultures of T hyodysenteriae 7 and 8 days after the last intravenous injection. Clinical signs of swine dysentery were observed in all 8 control pigs, but was observed in only 1 of the immunized pigs. Three control pigs died. These findings suggest that parenteral immunization with T hyodysenteriae provided a marked degree of protection against subsequent intragastric challenge exposure with the homologous isolate of T hyodysenteriae.
mesh_terms: D000818:Animals; D004403:Dysentery / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D007114:Immunization / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000473:pathology / Q000517:prevention & control*; D014208:Treponema / Q000276:immunology*; D014211:Treponemal Infections / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*