[Contusion and permeability of the hemato-aqueous barrier to fluorescein. Effect of a pretreatment by local indometacine (author's transl].
An experimental study, by angiography of the anterior segment of rabbit's eye, estimates the permeability of the hemato-aqueous barrier, using fluorescein. A trauma of the eye (contusion) leads to a rapid and significant increase in this permeability. However, local pretreatment, using an ophthalmic solution of 0,33% indometacine, almost completely stabilizes the hemato-aqueous barrier, even for elements as diffusible as fluorescein. These results suggest that application of a similar preparation to the human eye could be useful in the treatment of ocular contusions, chemical burns and angle-closure glaucoma. But the best perspective could be the application of the indometacine solution to the eye, before an operation, to reduce the sideeffects of surgery relative to the surgical break of the hemato-aqueous barrier.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology*; D001692:Biological Transport; D001769:Blood; D003288:Contusions / Q000188:drug therapy / Q000503:physiopathology; D005131:Eye Injuries / Q000188:drug therapy* / Q000503:physiopathology; D005451:Fluorescein Angiography; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions; D013508:Ophthalmologic Surgical Procedures; D010539:Permeability; D011817:Rabbits
D009883:Ophthalmic Solutions; D007213:Indomethacin
Contusion et perméabilité de la barrière hémato-aqueuse à la fluorescéine. Influence d'un pré-traitement par i'indométacine locale.