The radiosensitivity of T and B lymphocytes in mice.
The radiosensitivity of T and B lymphocytes in spleens of specific pathogen-free C3Hf/HeMs male mice was studied by the direct and indirect immunofluorescence technique. It was found that the radiobiological parameters characterizing the survival curve of Bpsi lymphocytes were DO = 200 R and n = 1-00. The T lymphocytes, on the other hand, were shown to consist of two distinct subpopulations with respect to their radiosensitivity. The radiobiological parameters of the radiosensitive fraction of T lymphocytes were Dq = 185 R, DO =195 R and n = 2-50. The DO value of the radioresistant T lymphocyte subpopulation was practically unmeasurable. It was estimated that approximately 8 per cent of the T lymphocytes present in the spleen of normal C3Hf mice belonged to this radioresistant subpopulation.
D000818:Animals; D001402:B-Lymphocytes / Q000528:radiation effects*; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002455:Cell Division; D002470:Cell Survival; D004307:Dose-Response Relationship, Radiation; D005455:Fluorescent Antibody Technique; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011828:Radiation Chimera; D011829:Radiation Dosage; D011830:Radiation Effects; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000528:radiation effects*; D014184:Transplantation, Homologous