Immunologic study of the brain as a privileged site.
A number of experimental findings reported here indicate that the brain functions as a privileged site not because of an afferent arc blockade, as hitherto thought, but because of an efferent arc blockade, with some afferent arc delay. There appears to be a quantitative deficiency in the efferent arc, but a qualitative defect is not ruled out. Implants survive four times as long in the brain as in the anterior chamber.
D000818:Animals; D000867:Anterior Chamber / Q000276:immunology; D001921:Brain / Q000276:immunology* / Q000473:pathology; D006085:Graft Survival; D006386:Hemagglutination Tests; D007959:Lymphocyte Culture Test, Mixed; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous