Acne vulgaris. Studies in pathogenesis: suppression of nonspecific esterases.
Oral tetracycline eliminated the histochemical staining for nonspecific esterase in human sebaceous glands after two weeks of administration. This evidence offers further support for the hypothesis that the clinical benefits of tetracycline result from suppression of follicular esterase-lipases, probably those from C. acnes.
D000135:Acid Phosphatase / Q000378:metabolism; D000152:Acne Vulgaris / Q000188:drug therapy / Q000201:enzymology* / Q000209:etiology; D004950:Esterases / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D012627:Sebaceous Glands / Q000201:enzymology; D012867:Skin / Q000201:enzymology; D013752:Tetracycline / Q000494:pharmacology* / Q000627:therapeutic use
D004950:Esterases; D000135:Acid Phosphatase; D013752:Tetracycline