[Reduction of glucose embryotoxicity by intra-ovulary injection of insulin].
The injection of 10 mg glucose and 0.4 U.I. of insulin in the ovulary fluid of 14th day rabbit embryo, produces less anomalies than the injection of the same concentration of glucose alone. This result shows that the insulin receptor is probably present in the 14th day rabbit embryo, before the differentiation of B cells in the pancreas.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007328:Insulin / Q000494:pharmacology / Q000627:therapeutic use*; D008722:Methods; D011247:Pregnancy; D011817:Rabbits; D011972:Receptor, Insulin / Q000187:drug effects
D007328:Insulin; D011972:Receptor, Insulin; D005947:Glucose
Réduction, par l'insuline, de l'action embryotoxique du glucose en injection intraovulaire.