title: Does cycloheximide-induced loss of phosphate uptake activity in Neurospora crassa reflect rapid turnover?
abstract: Addition of cycloheximide to Neurospora crassa germlings growing in liquid medium caused an exponential loss of phosphate uptake activity (half-life, ca. 2 h). No loss of activity resulted when germlings were resuspended, at the time of cycloheximide addition, in medium of a substantially lower phosphate concentration. It is concluded that the phosphate uptake systems are not subject to rapid turnover.
mesh_terms: D003513:Cycloheximide / Q000494:pharmacology*; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000187:drug effects / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*
chemical_list: D010710:Phosphates; D003513:Cycloheximide