Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino rats.
PGE1 potentiated, while diclofenac, a prostaglandin synthesis inhibitor, antagonized hexobarbitone hypnosis in rats. PGE1-induced potentiation of hexobarbitone sleep was inhibited by a 5HT synthesis inhibitor and by a 5HT receptor blocker, suggesting that this potentiation is 5HT mediated.
D000818:Animals; D004357:Drug Synergism; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D010648:Phenylacetates; D011458:Prostaglandins E; D012701:Serotonin; D006591:Hexobarbital; D010134:Fenclonine; D008784:Methysergide