At least two loci of the major histocompatibility complex can determine mixed lymphocyte stimulation in the rat.
Analysis of a recombinant haplotype of the major histocompatibility complex showed that two genetically separable loci (or groups of loci), LD--1 and LD--2, determine mixed lymphocyte stimulation in the rat. LD--1 maps into the H--1B region which contains the Ir genes and is associated with strong, mixed lymphocyte stimulation. LD--2 maps into the H--1A region and determines weak stimulation. LD--1 and LD--2 determinants can be detected by primed lymphocyte typing.
D000818:Animals; D002874:Chromosome Mapping; D005802:Genes, MHC Class II; D006238:Haploidy; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D051381:Rats; D011919:Rats, Inbred Strains; D011995:Recombination, Genetic