Dietary enhancement of CNS neurotransmitters.
Feeding choline, a precursor of the neurotransmitter acetylcholine, has been shown experimentally to increase brain acetylcholine release and enhance cholinergic function A subsequent trial of oral choline ameliorated symptoms in patients with tardive dyskinesia, which has been linked to cholinergic dysfunction. The findings suggest a role for dietary precursors in treating diseases associated with neurotransmitter abnormality.
D000109:Acetylcholine / Q000096:biosynthesis / Q000378:metabolism*; D000284:Administration, Oral; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004032:Diet; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy; D010830:Physostigmine / Q000008:administration & dosage; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000008:administration & dosage
D012701:Serotonin; D014364:Tryptophan; D010830:Physostigmine; D002794:Choline; D000109:Acetylcholine