Alkaloids of Thalictrum. XXII. Isolation of alkaloids with hypotensive and antimicrobial activity from Thalictrum revolutum.
Sixteen alkaloids were characterized from Thalictrum revolutum DC., namely; thalidasine, O-methylthalmethine, O-methylthalicberine, thalrugosaminine, thalicarpine, thalmelatine, pennsylvanine, palmatine, berberine, thalifendine, columbamine, jatrorrhizine, deoxythalidastine, thalphenine and magnoflorine. The structure of thairugosaminine (1) a bisbenzylisoquinoline type which was previously proposed on partial data was completely established, including the absolute configuration as S,S. Thalphenine, thalidasine, O-methylthalicberine, thalicarpine, thalrugosaminine and thaliglucinone were found to possess hypotensive activity in rabbits. Thalrugosaminine, thalicarpine, thalmelatine, O-methylthalmethine, pennsylvanine and thalphenine were found to be active against Mycobacterium smegmatis.
D000470:Alkaloids / Q000302:isolation & purification*; D000818:Animals; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000959:Antihypertensive Agents; D001060:Aporphines / Q000302:isolation & purification; D001599:Berberine / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D009161:Mycobacterium / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*; D011817:Rabbits
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000959:Antihypertensive Agents; D001060:Aporphines; D001599:Berberine