[Metabolic activation by adrenal tissue in rats of a liver carcinogen: safrole].
In vivo and in vitro metabolisms by the rat adrenal tissue of safrol, a natural hepatocarcinogen, were studied by gas chromatography-mass spectrometry and compared to the hepatic metabolism. In the adrenals the epoxide-diol pathway was found besides demethylase and hydroxylase activities, suggesting that the adrenal cortex may participate to the metabolic activation of a procarcinogen.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D004149:Dioxoles / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D051381:Rats; D012451:Safrole / Q000378:metabolism*
D004149:Dioxoles; D012451:Safrole
Activation métabolique par le tissu surrénalien du Rat d'un cancérogène du foie: le safrol.