[Changes in the mole fraction ratio of lactate dehydrogenase subunits in the lymphocytes of Down's syndrome patients].
A comparative study of the total activity and mole quota ratio of lactate dehydrogenase subunits in lymphocytes of 14 patients with Down's syndrome (trisomy-21) and in 10 healthy persons is carried out. Differences in the total activity in both groups were insignificant. In patients with Down's syndrome the mole quota ratio of H and M subunits of LDH was found to be significantly altered (p greater than 0.999): H = 33.2%, M - 66,8%, as compared to 51.5% and 48.4% in the control (healthy) group respectively. These differences are evaluated as a result of changed gene expression of both loci controlling H and M polypeptide chains of heteromeric enzyme molecule.
D055598:Chemical Phenomena; D002621:Chemistry; D004314:Down Syndrome / Q000201:enzymology / Q000235:genetics*; D005796:Genes; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D008214:Lymphocytes / Q000201:enzymology*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Izmenenie sootnosheniia mol'nykh doleĭ sb''edinits laktatdegidrogenazy v limfotsitakh bol'nykh s sindromom Dauna.