Effect of N'-methylnicotinamide on the renal accumulation and reabsorption of gentamicin in rats.
N'-methylnicotinamide, a substrate of the organic base transport system, reduced renal accumulation of [(14)C]gentamicin in rats by 15% and increased clearance by 25%, suggesting that gentamicin is not secreted by this mechanism.
D000042:Absorption; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D005260:Female; D005839:Gentamicins / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D005839:Gentamicins; D009536:Niacinamide