Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
Automutilation induced by a single large dose of clonidine was potentiated by pretreatment with methamphetamine, caffeine and theophyline, while it was inhibited by acute administration of reserpine, alpha-methyl-p-tyrosine, phenoxybenzamine, phentolamine and chlorpromazine. L-Dopa, 5-hydroxytryptophan and p-chlorophenylalanine had no effect on this abnormal behavior. Biochemical studies on brain monoamines revealed that noradrenaline was markedly increased and dopamine slightly so, but 5-hydroxytryptamine was never changed by clonidine. These results suggest that a central noradrenergic system may be involved in automutilation induced by clonidine in mice.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D002110:Caffeine / Q000494:pharmacology; D002395:Catecholamines / Q000032:analysis; D002746:Chlorpromazine / Q000494:pharmacology; D003000:Clonidine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012652:Self Mutilation / Q000139:chemically induced*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology
D002395:Catecholamines; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D002110:Caffeine; D008694:Methamphetamine; D007980:Levodopa; D012110:Reserpine; D013806:Theophylline; D006916:5-Hydroxytryptophan; D003000:Clonidine; D010134:Fenclonine; D002746:Chlorpromazine; D010646:Phentolamine