title: DNA replication in bacteriophage-infected Staphylococcus aureus.
abstract: The synthesis of viral and host DNA in phage-infected Staphylococcus aureus was examined. Three intracellular forms of phage 52HJD DNA were demonstrated: covalently closed circular, open circular, and linear DNA species. It was noted that infection of S. aureus-propagating strains 81 and 52 with phage 52HJD inhibited the replication of the bacterial chromosome and a stringently controlled penicillinase plasmid. A small tetracycline plasmid, normally under relaxed replication control, continued to replicate in the postinfection period. No breakdown of the host chromosome into small-molecular-weight fragments or utilization of bacterial DNA material for the synthesis of viral DNA was observed.
mesh_terms: D004269:DNA, Bacterial / Q000096:biosynthesis*; D004270:DNA, Circular / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis*; D009690:Nucleic Acid Conformation; D010405:Penicillinase; D010957:Plasmids; D013204:Staphylococcus Phages / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*; D013752:Tetracycline
chemical_list: D004269:DNA, Bacterial; D004270:DNA, Circular; D004279:DNA, Viral; D010405:Penicillinase; D013752:Tetracycline