Sarcoid.
Patients with sarcoidosis were separated into those treated or not treated with prednisone. Skin test reactivity of both groups was clearly diminished but a significant decrease in T-cells was seen only in the steroid-treated group and this was not sufficient to explain the profound energy. Lymphocyte stimulation studies generally revealed elevated baseline incorporation of [3H]thymidine and reduced stimulation. Factors were present in the plasmsa of 1/4 to 1/3 of the patients which suppressed normal lymphocyte stimulation. When cells from 3 sarcoid patients were precultured in vitro, recovery towards normal occurred with a drop of the elevated baseline and rise in peak response.
D000328:Adult; D002176:Candida albicans; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D037102:Lectins / Q000494:pharmacology; D007958:Leukocyte Count; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology*; D012882:Skin Tests; D013268:Stimulation, Chemical
D037102:Lectins; D004247:DNA