[On the reduction of free fatty acids in skin surface lipids as a criterium for the therapeutic efficacy of antimicrobial acne drugs. Studies on film masks containing ethyl lactate and ethanol (author's transl)].
Thin-layer chromatographic investigations of the skin surface lipids have been performed on 10 healthy subjects before and after treatment with film masks containing 1% ethyl lactate and 50% ehtanol. From the results obtained it can be assumed that there is a reduction in the fraction of free fatty acids on the skin surface. Clinical studies with the same mask on 23 patients with acne vulgaris over a period of 3 weeks proved that this treatment led to a significant reduction in comedones and inflammatory acne efflorescences. No side effects whatsoever were obtained. This therapy, therefore presents a valuable element in the treatment of acne vulgaris. These investigations show also that a decrease in the free fatty acids of the skin surface lipids points to a favourable therapeutical effect on inflamed and not-inflamed efflorescens of acne vulgaris when testing antimicrobial agents.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology* / Q000627:therapeutic use; D000431:Ethanol / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005260:Female; D006801:Humans; D007773:Lactates / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D000891:Anti-Infective Agents, Local; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D000431:Ethanol
Uber die Reduktion der freien Fettsäuren in den Hautoberflächenlipiden als Kriterium für die therapeutische Wirksamkeit antimikrobieller Aknetherapeutika. Untersuchungen mit äthyllactat- und äthanolhaltigen Filmmasken.