Behavioral sensitivity to LSD: dependency upon the pattern of central 5HT depletion.
Two experiments were carried out using a fixed ratio (FR) schedule of water reinforcement to determine the efficacy of two serotonin (5HT) depleting agents (p-chloroamphetamine, 5, 7-dihydroxytryptamine) in altering sensitivity to a low dose of LSD (0.02 MG/KG). The results showed that while both p-chloroamphetamine (PCA) and 5, 7 dihydroxytryptamine (5, 7 DHT) were efficacious in reducing whole brain 5HT, only 5, 7 DHT altered LSD sensitivity such that a 0.02 mg/kg dose of LSD given 12 days after 5, 7 DHT administration disrupted bar press behavior. This was not observed in animals given PCA within similar parameters. Moreover, 4 animals given PCA that did not show increased sensitivity to LSD, did show behavioral disruption to LSD (0.02 mg/kg when they were pretreated with p-chlorophenylalanine, Results are discussed on terms of a possible particular pattern of 5HT depletion that must be achieved before sensitivity to LSD is observed.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003216:Conditioning, Operant / Q000187:drug effects*; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule; D012701:Serotonin / Q000378:metabolism*; D014363:Tryptamines / Q000494:pharmacology; D010133:p-Chloroamphetamine / Q000494:pharmacology
D014363:Tryptamines; D012701:Serotonin; D010133:p-Chloroamphetamine; D008238:Lysergic Acid Diethylamide; D010134:Fenclonine