A comparison of drug-induced rotation in rats lesioned in the medial forebrain bundle with 5,6-dihydroxytryptamine or 6-hydroxydopamine.
Drug-induced rotational behaviour was studied in two groups of rats with differing chemical lesion of the right medial forebrain bundle (MFB). 6-hydroxydopamine (6-OH-DA), 3.5 mug, injected in one group, induced a marked lowering of dopamine (DA) and noradrenaline (NA) in the right hemiforebrain. 5,6-Dihydroxytryptamine (5,6-HT), 10 mug, injected in a second group, produced a profound and long-lasting depletion of 5-hydroxytryptamine (5-HT) and DA, but not of NA. Rotational behaviour induced in both groups by DA receptor agonists (apomorphine, piribedil, L-DOPA, ergometrine, ergocornine, 2-bromo-alpha-ergocryptine, ergocristine, methylergometrine) and agents releasing DA (d-methamphetamine, methylphenidate) were qualitatively identical and quantitatively very similar, suggesting a minor role of 5-HT striatal terminals in these experimental conditions. LSD induced contralateral rotation by direct stimulation of the DA receptor, while L-5-hydroxy-tryptophan (L-5HTP) was inactive.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004873:Ergolines / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D007031:Hypothalamus / Q000502:physiology*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D004130:N,N-Dimethyltryptamine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D011187:Posture; D051381:Rats; D012399:Rotation; D012701:Serotonin / Q000494:pharmacology; D013238:Stereotaxic Techniques; D013239:Stereotyped Behavior / Q000187:drug effects*; D014363:Tryptamines / Q000494:pharmacology*
D004873:Ergolines; D006892:Hydroxydopamines; D014363:Tryptamines; D012701:Serotonin; D008238:Lysergic Acid Diethylamide; D006220:Haloperidol; D010134:Fenclonine; D004298:Dopamine; D015115:5,6-Dihydroxytryptamine; D004130:N,N-Dimethyltryptamine; D009638:Norepinephrine