Thymus quantitative morphological changes during CCl4-induced liver cirrhosis.
The dynamics of the thymus cell densities was studied during CCl4-induced cirrhogenic hepatopathy. The results show that all thymus compartments take part in immune phenomena occurring in the whole lymphatic system. The maximal intensity of thymus participation is attained in precirrhosis and evolutive cirrhosis. Within the cortical zone, the cell density pyroninophilia and blast-transformed cells increase during the first two months. After two months, there is a decrease of the pyroninophilic elements within the cortical zone, concomitantly with their increase at the medullary level, thus suggesting a migration process of the cells, which change the cortical-medullary ratio.
D000818:Animals; D002251:Carbon Tetrachloride; D002452:Cell Count; D005260:Female; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D051381:Rats; D013601:T-Lymphocytes / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*; D013997:Time Factors
D002251:Carbon Tetrachloride