[Involvement of the thyroid gland in clinical shock (anti-shock action of propylthiouracil)].
Propylthyouracil, a synthetic anti-thyroid drug, was given intravenously in ten patients in a severe shock condition and its action was followed on the blood cathecholamines. This was assessed in venous blood according to a modified colorimetric method by Manuhin, before and 30 minutes after the substance was perfused. Although statistically non-significantly the two amines show a tendency to fall after the administration of the drug. In line with a series of previous studies carried out in various institutes of chemical and pharmaceutical research the drug was given for the first time in humans in shock conditions. Discussing the results obtained the administration of propylthyouracil is recommended, as an adjuvant therapy in severe shock.
D000311:Adrenal Glands / Q000503:physiopathology; D000818:Animals; D002395:Catecholamines / Q000097:blood; D004285:Dogs; D006801:Humans; D011441:Propylthiouracil / Q000627:therapeutic use*; D051381:Rats; D012769:Shock / Q000188:drug therapy* / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology*
D002395:Catecholamines; D011441:Propylthiouracil
Implicaţiile tiroidei în şocul clinic (acţiunea antişoc a propiltiouracilului)