title: [Toxicological characteristics of thaliblastine[].
abstract: The toxic action of the antiphlogistic drug thaliblastin, containing 93-95 per cent of the alcaloid thalicarpine was investigated. With its single intraperitoneal injection to mice the DL10 of the drug amounts to 273-306 mg/kg, DL50-325-350 mg/kg and DL90-370-402 mg/kg. With its 5-day long administration the respective figures for mice are 102-165, 125-201 and 154-243 mg/kg and for rats--170, 203 and 272 mg/kg. The respective figures for a 20-day long introduction to mice are 155, 185 and 220 mg/kg. Introduction of thaliblastin in doses of DL10 single and multiply results in a marked loss of the mass in mice.
mesh_terms: D000818:Animals; D001060:Aporphines / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006824:Hybridization, Genetic; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats
chemical_list: D001060:Aporphines; D010936:Plant Extracts
vernacular_title: Toksikologicheskaia kharakteristika taliblastina.