[Effects of tritoqualine on hepatic and blood levels of histamine after partial hepatectomy in rats].
Looked as a specific inhibitor of histidin-decarboxylase, tritoqualine has been injected subcutaneously to Wistar rats immediately after partial hepatectomy and, then, once in 24 hours until 72 hours. It has thus provoked : an unexpected, but transient rise (reaching its apex 3 hours after the operation) of the hepatic and blood histamin concentrations ; then, the expected decrease (more durable and greatest at 48 hours) of the same concentrations. Therefore, an effect of tritoqualine on the liver regeneration might be expected, whether histamin plays some part in this phenomenon.
D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D006498:Hepatectomy; D006632:Histamine / Q000097:blood / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D007546:Isoquinolines / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects*; D010795:Phthalic Acids / Q000494:pharmacology; D051381:Rats
D007546:Isoquinolines; D010795:Phthalic Acids; D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase
Action de la tritoqualine sur les taux hépatique et sanguin de l'histamine après hépatectomie partielle chez le Rat.