Effect of d-6-methyl-8-ergoline-i-ylacetamide (Deprenon) on the FSH content of the pituitary in castrated female rats.
The authors studied the effect of Deprenon (D-6-methyl-8-ergoline-I-acetylamide tartrate) on the FSH content of the adenohypophysis of female rats which had been castrated 3 and 6 weeks previously. The FSH content, determined by the method of Johnson and Naqui (1970), is expressed at the mean weights of the recipients' ovaries compared with a group given only 30 I.U. HCG. Within 30 min after administration, a single peroral dose of 0.5 mg Deprenon/kg produced a drop in the pituitary FSH content. This was not very pronounced 3 weeks after castration, but was highly significant 6 weeks after castration, when the amount of FSH in the control animals' pituitaries rose.
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D010053:Ovary / Q000601:surgery*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000081:Acetamides; D004873:Ergolines; D005640:Follicle Stimulating Hormone