In vivo DNA repair after N-methyl-N-nitrosourea administration to rats of different ages.
DNA repair time-course was studied after injury by N-methyl-N-nitrosourea (MNU) in rat liver cells of animals of different ages and in fetuses using hydroxyurea (HU) as inhibitor of scheduled DNA synthesis. DNA repair was a rapid phenomenon, more so in young adults than in newborns, and was not detectable in fetuses. A correlation seems to exist among organ sensitivity to carcinogen, age of animal and DNA repair.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000378:metabolism; D002843:Chromatin / Q000032:analysis; D004247:DNA / Q000302:isolation & purification; D004260:DNA Repair; D005260:Female; D005333:Fetus; D006918:Hydroxyurea / Q000009:adverse effects; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008770:Methylnitrosourea / Q000009:adverse effects*; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats
D002843:Chromatin; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D004247:DNA; D006918:Hydroxyurea