Chemically induced esthesioneuroblastomas in rats.
Malignant tumours of the nasal cavity were induced in 19 of 56 (34%) female MRC-Wistar rats by 1-nitrosopiperazine administered orally for life. These tumours were of neurogenic origin, according to classical histologic criteria.
D000818:Animals; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000139:chemically induced* / Q000473:pathology; D009603:Nitroso Compounds; D009669:Nose Neoplasms / Q000139:chemically induced / Q000473:pathology; D009831:Olfactory Mucosa; D010879:Piperazines; D051381:Rats
D009603:Nitroso Compounds; D010879:Piperazines