[Diuretic action of calcitonin: demonstration of an inhibiting effect on sodium reabsorption in the ascending limb of Henlé's loop].
It was found that calcitonin (porcine) at the dose: 4 I.U. MRC./kg/hr (i.v.), in the rabbit, increased the diuresis and oxmolal excretion, and simultaneously decreased free-water reabsorption and urinary osmolality. The results suggest that calcitonin acts by inhibiting sodium reabsorption in the ascending limb of Henl's loop. This hypothesis was confirmed by renal autoradiography study with 22Na.
D000818:Animals; D001345:Autoradiography; D001693:Biological Transport, Active / Q000187:drug effects; D002116:Calcitonin / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D007263:Infusions, Parenteral; D007684:Kidney Tubules / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000187:drug effects*; D011817:Rabbits
D002116:Calcitonin
Action diurétique de la calcitonine: mise en évidence d'un effet inhibiteur sur la réabsortion du sodium dans la branche ascendante de l'anse de Henlé