Immunological potential of yolk sac cells.
Mouse yolk sac cells on day 9 of gestation were found to elicit a GVH response, measured by enlargement of the local popliteal lymph nodes. The response cannot be attributed to contaminating maternal cells, since F1 (Balb/c x C57B1) yolk sac cells did not cause a reaction in F1 (Balb/c x C57B1) hosts. On the other hand, yolk sac cells did not elicit a detectable MLC reaction, nor did they respond to PHA or Con A. Hence, mouse yolk sac cells have the potential to express a certain limited array of immunological reactivities, before the development of embryonic thymus and liver.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007111:Immunity, Cellular; D007118:Immunoassay; D037102:Lectins / Q000494:pharmacology; D008198:Lymph Nodes; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008937:Mitomycins / Q000494:pharmacology; D014817:Vitelline Membrane / Q000166:cytology / Q000276:immunology*
D037102:Lectins; D008937:Mitomycins; D003208:Concanavalin A