Two restriction and modification systems in Staphylococcus aureus NCTC8325.
The presence of two distinct host specificities in Staphylococcus aureus strain NCTC8325 was revealed by the isolation of restriction- and modification-deficient mutants. The two host specificity systems, designated S1 and S2, are both active on phage 80mualpha but are not additive in their restricting activity. Restriction-deficient, modification-proficient mutants were invariably affected in both restriction systems. The functional relationship between these two systems is discussed.
D004269:DNA, Bacterial / Q000378:metabolism*; D005796:Genes; D009154:Mutation; D010641:Phenotype; D013204:Staphylococcus Phages; D013211:Staphylococcus aureus / Q000378:metabolism*
D004269:DNA, Bacterial