The role of histamine in wound healing I. The effect of high doses of histamine on collagen and glycosoaminoglycan content in wounds.
The effect of high doses of histamine (Hi) on collagen and glycosoaminoglycan (GAG) content in skin wounds of rats was studied on days 1, 3, 5, 10 and 14 after wounding. Injection of high doses of Hi into the wounded area inhibited colagen production, collagen polymerization and GAG synthesis; levels of chondroitin sulphates (chondroitin-4,6-sulphate and dermatan sulphate) and hyaluronic acid were decreased.
D000818:Animals; D002809:Chondroitin Sulfates / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003871:Dermatan Sulfate / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D012995:Solubility; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000378:metabolism*
D006025:Glycosaminoglycans; D003871:Dermatan Sulfate; D006632:Histamine; D006820:Hyaluronic Acid; D006493:Heparin; D002809:Chondroitin Sulfates; D003094:Collagen