[In vitro liberation of lymphocytic factors inhibiting migration of human leukocytes induced by gold, cadmium and mercury chlorides].
The presence of 300 microgram gold and cadmium and 10 microgram mercury chloride per millitre of survival medium, during the process of T.I.M.L., results in the release by human lymphocytes of soluble factors which inhibit migration of leucocytes (L.I.F. and M.I.F.). This stimulation of cellular immunity suggests that the anti-infectious therapeutic effect of gold and mercury inorganic salts results from activation of the histiocytary system, through the release of these lymphokins.
D002104:Cadmium / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D008628:Mercury / Q000494:pharmacology*
D002712:Chlorides; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D002104:Cadmium; D006046:Gold; D008628:Mercury
Libération, in vitro, de facteurs lymphocytaires inhibant la migration des leucocytes humains, induite par les chlorures d'or, de cadmium et de mercure.