Autoimmunity as possible evoking factor of some so-called idiopathic bone marrow hypoplasias.
Patients with bone marrow hypoplasia or aplasia were examined using the method of lymphocyte blast transformation and the MIF production test. The experimental results demonstrated the presence of an autoimmune process in these patients. A good congruence of the methods was demonstrated. Possible role of the autoimmune process in the pathogenesis of the disease as well as the reasons for the autoimmunity development and the therapeutical implications of these findings are discussed.
D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D001855:Bone Marrow Diseases / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis
D001323:Autoantibodies; D008263:Macrophage Migration-Inhibitory Factors