Inhibition of adenosine triphosphatase and carbonic anhydrase by contrast media.
In vitro inhibition of adenosine triphosphatase and carbonic anhydrase by several radiographic contrast media and other compounds was measured. The concentrations required for 50% inhibition were, in general, similar to those obtained for other enzymes. The effect of methylglucamine could not be determined for either enzyme because of interference with the assays.
D000086:Acetazolamide / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D001692:Biological Transport / Q000187:drug effects; D002257:Carbonic Anhydrase Inhibitors; D003287:Contrast Media / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D007474:Ion Exchange; D010042:Ouabain / Q000494:pharmacology
D002257:Carbonic Anhydrase Inhibitors; D003287:Contrast Media; D010042:Ouabain; D005665:Furosemide; D000251:Adenosine Triphosphatases; D000086:Acetazolamide