[The mechanism of the acute action of insulin (author's transl)].
All the known acute actions of insulin are based on the reaction of insulin with specific insulin receptors in the cell membranes of the insulin-sensitive organs. The reaction of insulin with these receptors leads, through changes in the membrane structure, to changes in the permeability of the cell membrane, the activity of the normal membrane K+/Na+ATPase and adenyl cyclase. From this results the multiplicity of acute insulin effects on numerous metabolic quantities, following a kind of intensifier system. Under physiological conditions, the effect of insulin on the liver metabolism plays the central role for the maintenance of blood sugar homeostasis.
D000179:Acrylates; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008970:Molecular Weight; D010649:Phenylalanine; D011108:Polymers; D011188:Potassium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug
D000179:Acrylates; D001786:Blood Glucose; D007328:Insulin; D011108:Polymers; D011506:Proteins; D011955:Receptors, Drug; D010649:Phenylalanine; D006003:Glycogen; D000251:Adenosine Triphosphatases; D000262:Adenylyl Cyclases; D005947:Glucose; D011188:Potassium
Zum Mechanismus der akuten Insulinwirkung