[Haloperidol, reserpine, l-dopa and amantidine in the treatment of Huntington chorea (author's transl)].
Two drugs that should reduce striatal dopamine activity (haloperidol and reserpine) and two other drugs that should increase it (L-Dopa and amantadine) have been successively adminstered to six patients suffering from Huntington's Chorea. The most effective treatment in reducing hyperkinesis was haloperidol, followed by reserpine. Treatment with L-Dopa did not have appreciable effect, on this type of involuntary movements. Against some theoretical expectations administration of amantadine was followed by a slight improvement in the control of involuntary activity.
D000328:Adult; D000368:Aged; D000547:Amantadine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004296:Dopa Decarboxylase / Q000627:therapeutic use; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012110:Reserpine / Q000627:therapeutic use*
D007980:Levodopa; D012110:Reserpine; D000547:Amantadine; D004296:Dopa Decarboxylase; D006220:Haloperidol; D003975:Diazepam
Terapia della chorea di Huntington azione del serenase, reserpina, l-dopa, amatadina sulle ipercinesie coreiche