Transmission of Creutzfeldt-Jakob disease to the stumptail macaque (Macaca arctoides).
The successful transmission of Creutzfeldt-Jakob disease from both affected human and chimpanzee brain to stumptail macaques has been accomplished. The incubation period of 5 yr was the same for both animals; however, the course of the disease was longer in the animal receiving the human brain. In both cases, initial mild symptoms slowly remitted only to reappear some 4 mo later. Muscle biopsies revealed changes suggestive of a mild neuropathy. In addition, there appeared to be an increased ability to incorporate 3H-thymidine in untreated cultures of lymphocytes from peripheral blood.
D000818:Animals; D001253:Astrocytes / Q000473:pathology; D001706:Biopsy; D001921:Brain / Q000473:pathology*; D003208:Concanavalin A / Q000494:pharmacology; D007562:Creutzfeldt-Jakob Syndrome / Q000635:transmission*; D000882:Haplorhini; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D008251:Macaca / Q000097:blood; D009132:Muscles / Q000473:pathology; D002679:Pan troglodytes; D013116:Spinal Cord / Q000473:pathology*; D013997:Time Factors
D037102:Lectins; D003208:Concanavalin A