The effect of long term tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man.
R factors are known to be the most important mechanism of antimicrobial resistance of intestinal flora. Short courses with therapeutic doses (1000 mg/day) of tetracycline select for strains containing transferable resistance factors to more than one antimicrobial agent. In this report we show that long term treatment with very low doses (100 mg/day) of tetracycline for acne vulgaris has an equally strong effect favouring establishment of resistent strains and R factors in the intestinal flora of patients.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology; D008297:Male; D010403:Penicillin Resistance / Q000187:drug effects; D011815:R Factors / Q000187:drug effects; D013307:Streptomycin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D013449:Sulfonamides; D000667:Ampicillin; D013752:Tetracycline; D013307:Streptomycin