title: Studies in relation to endocrine exophthalmos: the biochemical composition of human retrobulbar connective tissue.
abstract: As part of studies on the pathogenesis of exophthalmos of Graves' disease, the biochemical composition of human retrobulbar tissue was investigated. The connective tissue was composed of 72.7% lipid, 23.8% water and 3.5% dried defatted tissue. Total tissue glycosaminoglycan (GAG) amounted to 0.18% of dried defatted tissue. Approximately 27% of the total hexosamine and 19% of the total tissue galactosamine were recovered in the GAG fraction. Cellulose microcolumn fractionation of GAG showed that the hyaluronic acid and dermatan sulfate were the two major GAG species.
mesh_terms: D000368:Aged; D003238:Connective Tissue / Q000032:analysis*; D005094:Exophthalmos; D005123:Eye; D006025:Glycosaminoglycans / Q000032:analysis; D006595:Hexosamines / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000032:analysis; D008875:Middle Aged; D011506:Proteins / Q000032:analysis; D014574:Uronic Acids / Q000032:analysis; D014867:Water / Q000032:analysis
chemical_list: D006025:Glycosaminoglycans; D006595:Hexosamines; D008055:Lipids; D011506:Proteins; D014574:Uronic Acids; D014867:Water