[The effects of dl-sotalol on the urinary osmolarity of anesthetized dogs].
The effect of dl-sotalol (intrarenal perfusion of 19 mg/kg during 30 min) on urinary concentration was studied under pentobarbital anaesthesia in dehydrated dogs. Sotalol infusion decreased urinary osmolality and increased natriuresis and urine flow. This diuretic action was accompanied by the reduction of the renin hypersecretion elicited by water deprivation.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009994:Osmolar Concentration; D012083:Renin / Q000097:blood; D013015:Sotalol / Q000494:pharmacology*; D014868:Water Deprivation
D013015:Sotalol; D012083:Renin
Effets du dl-sotalol sur l'osmolarité urinaire chez le chien anesthésié