Hazards of steroid therapy in hepatic failure.
Three patients with extensive skin disease and liver failure are described. Two were treated with large amounts of topical corticosteroids and one with a small oral dose of betamethasone. The former two patients developed Addisonian crises when they failed to apply the topical steroids and all three patients developed aseptic necrosis of bone. This report emphasizes that the hazards of steroid therapy may be increased in patients with hepatic failure.
D000208:Acute Disease; D000224:Addison Disease / Q000188:drug therapy; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D001623:Betamethasone / Q000009:adverse effects* / Q000627:therapeutic use; D003873:Dermatitis, Exfoliative / Q000188:drug therapy; D004485:Eczema / Q000188:drug therapy; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D001623:Betamethasone