[Determination of the origin of drugs by measuring natural isotope contents: D/H and 13C/12C ratios of some diazepam samples (author's transl)].
The precise determination of the natural isotopic abundance ratios of carbon and hydrogen in several production batches of the commercial product 7-chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-on (diazepam) gave results which allowed certain batches to be differentiated. The differences in the ratios appear to be mainly due to differences in the isotopic composition of the (fossile) starting materials of the synthesis. The measurement of the natural isotopic ratios may therefore offer another possibility to determine the origin of a drug.
D002247:Carbon Isotopes / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D003903:Deuterium / Q000032:analysis*; D003975:Diazepam / Q000032:analysis* / Q000138:chemical synthesis; D006859:Hydrogen / Q000032:analysis*; D013557:Switzerland; D014481:United States
D002247:Carbon Isotopes; D006859:Hydrogen; D003903:Deuterium; D003975:Diazepam
Herkunftsbestimmung von Arzneimitteln durch Messung von natürlichen Isotopenverhältnissen: D/H und 13C/12C Verhältnisse einiger Proben von Diazepam