The Sézary syndrome cell: surface ultrastructural characteristics.
Peripheral blood mononuclear cells from a patient with Sézary syndrome which lacked E-rosette-forming ability and surface immunoglobulins, and which displayed a markedly depressed response to a variety of mitogens, were studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) on 3 occasions.  The first peripheral blood sample (smooth) differed significantly from two later samples (moderate numbers of microvilli) when surface characteristics were examined by SEM; these differences were confirmed by TEM.  The Sézary syndrome cells in this patient may be related to a T lymphocyte which has lost certain surface markers and mitogen response characteristics through a process of de-differentiation.
D002462:Cell Membrane / Q000648:ultrastructure; D003873:Dermatitis, Exfoliative / Q000097:blood / Q000473:pathology*; D004912:Erythrocytes / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000097:blood / Q000473:pathology; D008206:Lymphatic Diseases / Q000097:blood / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D008934:Mitogens / Q000097:blood / Q000494:pharmacology; D009000:Monocytes / Q000648:ultrastructure; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013577:Syndrome; D013601:T-Lymphocytes / Q000648:ultrastructure
D008934:Mitogens; D011947:Receptors, Antigen, B-Cell