[Indole alkaloids induction of tremors: effect on photosensible epilepsy in Papiopapio].
Harmaline and ibogaine i.v. administration induced in the photosensitive baboon restlesness and tremor (8-12 Hz). The former increased the EEG frequency particularly in central regions with appearance of bursts at 20-24 c/s and blocked by somatic movement. The latter produced a slight enhancement of frontal fast rhythms. Both drugs blocked the spontaneous paroxysmal activity with little effect on photosensitivity. These effects lasted for 2-4 hrs. Vincamine produced agitation during 15 min. post-i.v.-administration and showed an "hypervigilant" EEG. Nor vincamine or Hydergine altered the degree of photosensitivity. Cerebellar involvement in the action of harmaline and ibogaïne is discussed.
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology; D000882:Haplorhini; D006246:Harmaline / Q000494:pharmacology; D007050:Ibogaine / Q000494:pharmacology; D010215:Papio; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012640:Seizures / Q000209:etiology*; D014202:Tremor / Q000139:chemically induced*; D014748:Vinca Alkaloids / Q000494:pharmacology
D000470:Alkaloids; D014748:Vinca Alkaloids; D004088:Dihydroergotoxine; D007050:Ibogaine; D006246:Harmaline
Alcaloïdes indoliques induisant ou non un tremblement : effets sur l'épilepsie photosensible du Papio papio