title: The response of C3H mice to streptozotocin. I. Thymic depression and leukocyte toxicity.
abstract: Streptozotocin, an antibiotic with reported antileukemic activity, was administered to C3H mice to evaluate the response of peripheral blood leukocytes and thymic lymphocytes. The hematologic effects of a single diabetogenic dose of streptozotocin include an absolute neutropenia and a depression of tritiated thymidine incorporation into thymic lymphocytes.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013311:Streptozocin / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism*
chemical_list: D013311:Streptozocin; D013936:Thymidine