[Sequence variation on an antibiotically active tripeptide (author's transl)].
Seven tripeptides with the sequence L-Arg-D,L-X-L-Phe were synthesised. Three of these peptides showed antibiotical activity on fungi. The amino- and the carboxylic terminus of the peptide L-Arg-D,L-Phe-L-Phe, which showed antibiotical activity, were changed to give the sequences L-X-D,L-Phe-L-Phe or L-Arg-D,L-Phe-L-X respectively. The resulting tripeptides showed no antibiotical activity.
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000032:analysis*; D000935:Antifungal Agents / Q000032:analysis; D001120:Arginine; D001412:Bacillus subtilis / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008970:Molecular Weight; D009089:Mucor / Q000187:drug effects; D009842:Oligopeptides / Q000032:analysis* / Q000494:pharmacology; D010649:Phenylalanine
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009842:Oligopeptides; D010649:Phenylalanine; D001120:Arginine
Sequenzvariationen an einem antibiotisch wirksamen tripeptid