The immunological relationship between filtrable agent, Salmonella and murine leukosis.
Salmonella typhimurium was invariably isolated from our J strain murine leukosis. Immunization of D103 mice with either inactivated Salmonella typhimurium or the cell-free extract of leukosis inhibited the transplantation of leukosis. The adoptive immunization of D103 mice with spleen cells of Strong A mice immunized with either Salmonella or the cell-free extract of leukosis inhibited the transplantation of leukosis. The addition of either Salmonella or the cell-free extract of leukosis inhibited the migration of macrophages of leukosis spleen in tissue culture. Strong A mice is non-susceptible to J strain leukosis. However, inoculation of neonatal Strong A mice with the cell-free extract of leukosis produced a susceptibility to the transplantation of leukosis. These results suggest that both a filtrable agent and Salmonella typhimurium are present in cells of this leukosis and might be etiologically related to the leukosis.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D000956:Antigens, Viral / Q000008:administration & dosage; D002464:Cell Migration Inhibition; D002474:Cell-Free System; D007108:Immune Tolerance; D007114:Immunization; D007942:Leukemia, Experimental / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D009368:Neoplasm Transplantation; D012190:Retroviridae / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*
D000942:Antigens, Bacterial; D000956:Antigens, Viral