Dosage effect of SOD-A gene in 21-trisomic cells.
SOD-A activity was measured by the polarographic method of catalytic currents in 30 subjects 10-24 years of age with a karyotype 47, + 21, and 30 age matched normal subjects. The ratio of the average amount of SOD-A in 21-trisomic cells to the average amount in normal cells is 1.4495. Statistical analysis confirms that this ratio does not differ significantly from the ratio 1.5 expected in the case of a simple gene dosage effect.
D000293:Adolescent; D000328:Adult; D002648:Child; D002904:Chromosomes, Human, 21-22 and Y; D004314:Down Syndrome / Q000201:enzymology* / Q000235:genetics; D005796:Genes; D006801:Humans; D010641:Phenotype; D013482:Superoxide Dismutase / Q000032:analysis*
D013482:Superoxide Dismutase