[Reversible inhibition of nucleolar function in fibroblasts treated in vitro with adriamycin].
In chick embryo fibroblasts treated in vitro with adriamycin, the mitotic activity is strongly depressed, the nucleoli are altered, nucleolar RNA synthesis is inhibited and the RNA content is lowered. These effects can be concomitantly and spontaneously reversible, but the mitotic activity does not resume.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000378:metabolism*; D002642:Chick Embryo; D004317:Doxorubicin / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis
D012313:RNA; D004317:Doxorubicin
Inhibition réversible de la fonction nucléolaire dans des fibroblastes traités in vitro par l'adriamycine.