[Experimental studies on tumorigenic activity of cigarette smoke condensate on mouse skin. V. Comparative studies of condensates from different modified cigarettes (author's transl)].
The tumorigenic effect of smoke condensates from reference cigarettes and different modified cigarettes has been investigated on the mouse skin. The following results have been obtained: 1. Reconstituted tobacco sheets made from the blend of the reference cigarette T as well as different other tobacco mixtures showed a reduced tumorigenic effect. 50% or 20% of reconstituted tobacco sheets as additive to the tobacco T showed reduced tumorigenic effect too. 2. A dark tobacco mixture (cigar type) as well as the Virginia tobacco of the mixture T showed no significant differences in biological activity compared to the reference tobacco. Condensate of the Burley tobacco of the blend T showed a reduced tumorigenic effect. 3. A small amount of nitrate as additive (1.8% total nitrate) only showed a limited reduction of the tumorigenic effect. 4. Condensate of a cigarette with commercially used filters, 20% reconstituted tobacco sheets and a total nitrate content of 1.8% showed a distinctly reduced tumorigenic effect. 5. Statistical evaluations of this experiment indicated that each of the applied dose should not be too high. Application of high doses did not lead to a further increase of tumor incidence. Cytotoxicity and viscosity of higher concentrated solutions may be responsible for this fact.
D000818:Animals; D001580:Benzopyrenes; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental; D009566:Nitrates; D010947:Plants, Toxic; D012878:Skin Neoplasms / Q000139:chemically induced*; D012907:Smoking / Q000150:complications*; D014026:Nicotiana
D001580:Benzopyrenes; D002273:Carcinogens; D009566:Nitrates
Experimentelle Untersuchungen über die tumorerzeugende Wirkung von Zigarettenrauch-Kondensaten an der Mäusehaut. V. Mitteilung: Einzelvergleiche von Kondensaten verschiedener modifizierter Zigaretten