[Spontaneous transformation in LTT of patients with atopic dermatitis and other allergic skin diseases (author's transl)].
Increased spontaneous transformation rates have been repeatedly found in the LTT of patients with neurodermits or other diseases. We were interested in the question, if they are to induce artificially. On 37 voluntary persons the LTT was performed before, 24, 48 hours and 1, 2, 3 and 4 weeks after an intracutaneous injection of 0,1 ml of Candidin. On 19 test persons a statistically significant and on further 4 a distinct increase of spontaneous transformed cells in the LTT was to record compared with the culture before the injection of the antigen. This phenomenon was only to detect on low levels of spontaneous transformation (to 3%) in the initial culture. The importance of this observation is discussed in regard to immunological processes in the organism during an antigen exposition as well as to its relation with the evaluation of the LTT.
D000328:Adult; D000941:Antigens; D003876:Dermatitis, Atopic / Q000276:immunology*; D004485:Eczema / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D011134:Polysaccharides
D000941:Antigens; D011134:Polysaccharides
Spontantransformation im LTT bei atopisch-endogenem Ekzem und anderen Allergodermien.