[Effect of pGlu-Tyr-Arg-Trp-NH2 on the serum level of gonadotropins in the male rat].
The tetrapeptide synthesized by Folkers et al. was injected intraperitonealy in normal adult male rats. The release of FSH is significant 90 and 120 minutes after injections of 150, 100, 250 microgram of this substance. An increase of LH was only observed at 120 minutes after injection of 100 microgram of the tetrapeptide. Thus, in rats dissociation between FSH and LH release can be observed.
D000818:Animals; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D007274:Injections, Intraperitoneal; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D051381:Rats
D006065:Gonadotropins, Pituitary; D009842:Oligopeptides; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Influence du pGlu-Tyr-Arg-Trp-NH2 sur le taux sérique des gonadotrophines chex le rat mâle.