[Animal experiments concerning the neurotoxicity of aminoglycosid antibiotics. Electron microscopic findings regarding dose--depending mitochondrial damage in the cochlear nucleus of the guinea pig (author's transl)].
In 34 guinea pigs (plus 8 healthy animals for control) Gentamicin, Tobramycin and Amikacin show a characteristic pattern of mitochondrial damage in the cochlear nucleus of the guinea pig after a 10-day-administration of 4/40 mg/kg body weight Gentamicin, 4/50 mg/kg Tobramycin, respectively 15/75/150 mg/kg Amikacin. Amikacin causes the most pronounced physiological damage observed by the early loss of Preyer reflex and general toxic signs--these observations correspond with the morphological findings. By the evaluation of morphological findings we are convinced that there is indication for a direct neurotoxic effect on mitochondria in the cochlea nucleus regarding the dose and time of administration.
D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003056:Cochlear Nerve / Q000187:drug effects* / Q000648:ultrastructure; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006168:Guinea Pigs; D007612:Kanamycin / Q000031:analogs & derivatives*; D008928:Mitochondria / Q000187:drug effects; D009410:Nerve Degeneration; D014031:Tobramycin / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin; D014031:Tobramycin
Morphologische Untersuchungen zur Neurotoxizität von Aminoglykosidantibiotika--Elektronenmikroskopische Befunde dosisabhängig induzierter Mitochondrienschädigung im Nucleus cochlearis des Meerschweinchens