[Action of glibenclamide on glucagon and insulin secretions studied on isolated and perfused pancreas of the rat].
Glibenclamide stimulates the insulin secretion by the isolated and perfused rat pancreas, but does not inhibit glucagon secretion when the perfusion liquid contains 1.5 g/I glucose. In the absence of glucose in the perfusion medium, glibenclamide stimulates both insulin and glucagon secretions.
D000818:Animals; D001786:Blood Glucose; D005934:Glucagon / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects*; D010477:Perfusion; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D005905:Glyburide
Action du glibenclamide sur les sécrétions de glucagon et d'insuline étudiées sur le pancréas isolé et perfusé du rat