Unstable S-Adenosylmethionine synthetase in an ethionine-resistant strain of Neurospora crassa.
A pleitropic ethionine-resistant mutant of Neurospora contains an S-adenosylmethionine synthetase that is labile to heat and dialysis but exhibits normal kinetics for methionine and ethionine.
D003956:Dialysis; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D004789:Enzyme Activation; D005001:Ethionine / Q000378:metabolism / Q000494:pharmacology; D006358:Hot Temperature; D008715:Methionine / Q000378:metabolism; D008716:Methionine Adenosyltransferase / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D013696:Temperature; D014166:Transferases / Q000378:metabolism*
D008715:Methionine; D014166:Transferases; D008716:Methionine Adenosyltransferase; D005001:Ethionine