[Mechanisms of the antilipemic action of niacin].
In tests conducted with albino rats the influence of nicotinic acid, nicotinamide, hydrocortisone and their combinations on a number of factor characterizing directly or indirectly the state of the lipid metabolism in the liver was investigated. It is suggested that hormonal mediation (preliminary stimulation of the suprarenals) may play a significant part in the realization of hypolipemic activity of niacin, its concrete mechanism being oxidation of the lipids, controlled by corticosteroids.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000315:Adrenalectomy; D000818:Animals; D003065:Coenzyme A / Q000378:metabolism; D000960:Hypolipidemic Agents; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D009536:Niacinamide / Q000494:pharmacology; D009539:Nicotinic Acids / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; D009536:Niacinamide; D003065:Coenzyme A
O mekhanizmakh antilipemicheskogo deĭstviia niatsina.