The salt-resistance mechanism of Staphylococcus aureus examined by salt-sensitive mutants.
Two NaCl-sensitive mutants of S. aureus 209P (S-16 and S-23) were isolated after treatment of the parental strain with N-methyl-N'-nitro-N-nitrosoguanidine. Examination of the lipid components revealed that S-16 contained no cardiolipin and that S-23 contained only a small amount of cardiolipin. An increase of cardiolipin was indispensable for S. aureus proliferation in high NaCl medium.
D002308:Cardiolipins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003470:Culture Media; D009154:Mutation; D012965:Sodium Chloride / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000378:metabolism*
D002308:Cardiolipins; D003470:Culture Media; D012965:Sodium Chloride