[Die therapeutischen Grundlagen des exogen-allergisch ausgelösten Bronchospasmus].
A brief survey is given on the current theories and knowledge of therapy of bronchospasm. The results, obtained in 11 patients with proven atopy, regarding their response to the anticholinergic inhalant ipratropium-bromide (Atrovent) after artificial bronchospasm induced by specific allergen and acetylcholin, respectively, are being discussed. The therapeutic response was largely dependent on the level of preceding bronchospasm, quantitated by airway resistance. This phenomenon was more pronounced in allergen than in acetylcholin-induced asthma. The differences were of statistical significance by means of covariant analysis. The clinically relevant aspects of this finding are being discussed.
D000293:Adolescent; D000328:Adult; D000485:Allergens; D001249:Asthma / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000188:drug therapy*; D002648:Child; D004341:Drug Evaluation; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012138:Respiratory Therapy
D000485:Allergens; D005280:Fenoterol; D009241:Ipratropium