Effect of ACP (pyridoxine-2-oxoglutarate) on CCl4 intoxication and in streptozotocin-induced ketosis in rat.
The protective effect of pyridoxine-2-oxoglutarate (ACP) was studied on CCl4-intoxicated rats. A sensitive improvement of hepatic conditions was shown in ACP-treated rats as compared with untreated ones and rats treated with 2-oxoglutarate and pyridoxine. Serum GOT, GPT, OCT activities, composition of serum proteins, liver mitochondria respiratory control index and liver microsomes oxidizing activity were tested. The antiketotic properties of ACP were also demonstrated in Streptozotocin treated rats.
D000138:Acidosis / Q000188:drug therapy*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000494:pharmacology / Q000627:therapeutic use*; D007662:Ketosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D011736:Pyridoxine / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013311:Streptozocin; D000637:Transaminases / Q000097:blood
D001798:Blood Proteins; D007656:Ketoglutaric Acids; D013311:Streptozocin; D000637:Transaminases; D011736:Pyridoxine