title: [The effects of age and sex on the acute toxicity of two barbiturate anesthetics in rats].
abstract: The study of the acute toxicity of two barbiturics anaesthetics (pentobarbital and thiopental) shows the newborn period a higher susceptibility of the young rat, probably due to an immaturity of biotransformations enzymatic systems or to an increased blood-brain-barrier permeability.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D008297:Male; D010424:Pentobarbital / Q000633:toxicity*; D051381:Rats; D012737:Sex Factors; D013874:Thiopental / Q000633:toxicity*
chemical_list: D010424:Pentobarbital; D013874:Thiopental
vernacular_title: Influence de l'âge et du sexe sur la toxicité aiguë de deux anesthésiques barbituriques chez le rat.