title: Alpha-hydroxylation in the metabolism of N-nitrosopiperidine by rat liver microsomes: formation of 5-hydroxypentanal.
abstract: Metabolism of n-nitrosopiperidine by a purified microsomal preparation from rat liver was shown to yield 5-hydroxypentanal. This is the predicted product for a pathway involving an initial oxidation of the nitrosamine at the carbon atom alpha to the nitroso group.
mesh_terms: D000447:Aldehydes / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D006900:Hydroxylation; D066298:In Vitro Techniques; D007536:Isomerism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism*; D051381:Rats
chemical_list: D000447:Aldehydes; D009603:Nitroso Compounds; D010880:Piperidines; C016508:5-hydroxypentanal