[Adenosine triphosphate (ATP) and glucose. Action on insulin and glucagon secretion].
ATP stimulates glucagon and insulin secretions from the isolated perfused rat pancreas. This effect is modulated by glucose. Glucagon secretion is stimulated by ATP only in the absence or in the presence of a low glucose concentration (0.5 g/1). As to insulin secretion, it is strongly stimulated only in the presence of a glucose concentration of 1.5 g/1.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D007328:Insulin; D000255:Adenosine Triphosphate; D005934:Glucagon; D005947:Glucose
Adénosine triphosphate (ATP) et glucose. Action sur les sécrétions d'insuline et de glucagon