Changes in the stimulatory capability of mouse small thymocytes to give a proliferation of allogenic spleen cells during differentiation.
Our previous studies on surface antigenic properties of murine small thymocyte subpopulations raised the hypothesis that some of the least dense cells, which possibly were precursor T cells, differentiated into the most dense cells which have the properties of mature T cells. Thus, the stimulatory capacity of the least dense was compared with that of the most dense by one-way mixed leukocyte culture. A marked difference in capacity between both subpopulations was found, i.e., the capacity of the least dense was the strongest of all subclasses, whereas that of the most dense was the weakest. It was concluded from discussions on this difference that the finding supported the hypothesis.
D000818:Animals; D002454:Cell Differentiation; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D008937:Mitomycins; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D008937:Mitomycins