Platelet monoamine oxidase activity in Huntington's chorea.
The possibility that genetically determined abnormalities in the monoamine oxidase of certain central nervous system aminergic neurones may play a part in the pathology of Huntington's chorea was investigated using human platelet monoamine oxidase. Significantly elevated monoamine oxidase activity was found in male patients compared to control subjects suggesting this may be a screening test for this disorder. Low monoamine oxidase activity was associated with a better clinical response to drugs.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy / Q000201:enzymology*; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010868:Pimozide / Q000627:therapeutic use; D012737:Sex Factors; D013747:Tetrabenazine / Q000627:therapeutic use
D010868:Pimozide; D008094:Lithium; D008995:Monoamine Oxidase; D006220:Haloperidol; D013747:Tetrabenazine