Congenital and experimentally induced complement deficiency in rabbits.
Deficiency of the sixth component of complement in rabbits is an autosomal recessive defect which also renders C7-9 functionally unavailable. The function of C6-9 appears to be that of amplification of immunologic processes. Defective animals are associated with a subtle disadvantage. Normal rabbits injected with cobra-venom-anticomplementary-factor show primary C3-9 and secondary polymorphonuclear leukocyte and platelet functional deficiency. Animals treated with cobra venom showed striking deficits in manifestations of some immunologic functions. Thus the complement system plays a vital role in maintaining integrity of immunologic mechanisms.
D000818:Animals; D001183:Arthus Reaction; D003183:Complement C6 / Q000172:deficiency*; D003165:Complement System Proteins / Q000172:deficiency*; D004731:Endotoxins / Q000494:pharmacology; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D011817:Rabbits; D012790:Shwartzman Phenomenon; D012911:Snakes; D014688:Venoms / Q000494:pharmacology
D003183:Complement C6; D004731:Endotoxins; D014688:Venoms; D003165:Complement System Proteins