title: Interaction of bacterial cell wall polymers and rat macrophages.
abstract: Processing of group A and group D streptococcal cell wall was measured after phagocytosis by normal rat peritoneal cells in tissue culture. Group A cell wall was practically non-biodegradable in contrast to group D, which was over 80% degraded by 4-8 days in culture. There was no difference in elimination or degradation of mucopeptide or polysaccharide of group A cell walls. Neither antiserum or sensitized lymphocytes affected persistence. Macrophages from Fisher rats (susceptible to group A cell wall-induced polyarthritis) became cytotoxic for target L-cells 6-7 days after ingestion of group A cell walls. Phagocytosis of group D cell walls induced less cytotoxicity. Macrophages from Buffalo rats (resistant to polyarthritis) were less cytotoxic after phagocytosis of group A cell walls than Fisher macrophages. Soluble cytotoxins could not be detected in macrophage culture media.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002473:Cell Wall / Q000378:metabolism*; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D013293:Enterococcus faecalis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D009088:Mucoproteins / Q000378:metabolism*; D010587:Phagocytosis; D011135:Polysaccharides, Bacterial / Q000378:metabolism*; D051381:Rats; D011915:Rats, Inbred BUF; D011916:Rats, Inbred F344; D013297:Streptococcus pyogenes / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D009088:Mucoproteins; D011135:Polysaccharides, Bacterial