Strong mixed lymphocyte reaction associated with the LA or first locus HL-A.
Bidirectional strong stimulation in one-way mixed lymphocyte cultures (MLC) is reported between an HL-A recombinant and sibling, apparently differing only at the LA or first locus HL-A. The strong MLC reaction may represent a second strong MLR-S locus associated with the LA or first locus HL-A. Alternative explanations are discussed. A second example of a recombinant HL-A haplotype transmitted to progeny is also reported.
D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens; D006801:Humans; D007125:Immunogenetics; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D006680:HLA Antigens; D006649:Histocompatibility Antigens