Expression of C4 on human lymphoid cells and possible involvement in immune recognition phenomena.
Immunochemical studies revealed the presence of the fourth component of complement (C4) on surfaces of human lymphoid cells. Antiserums to C4 inhibited the mixed lymphocyte reaction and the mitogenic response to phytohemagglutinin, suggesting a role for membrane-associated C4 in the afferent phase of immune recognition phenomena.
D000937:Antigen-Antibody Reactions; D002460:Cell Line; D003181:Complement C4; D003165:Complement System Proteins; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D013499:Surface Properties
D003181:Complement C4; D006680:HLA Antigens; D003165:Complement System Proteins