[The origin of malignant tumors of the upper-airways, the digestion tract and the ear. Organ-resistance and organ-disposition (organotrophy) by the origin of malignant primary tumors (author's transl)].
Carcinomas of the nose, the trachea, the mouth, the esophagus and the middle ear are rarely observed. Those of the larynx and of the bronchial system are more often found. The reason for this cannot be related to differing contacts with carcinogenic substances. The differences in frequence ar dependent on the varied resistance and disposition of the organs involved (Organotrophy, Histotropy). This is comparable to the incidence of epithelial and mesenchymal tumors. The tissues do not only vary in their structure. The differences are found in 1. the velocity of cell regeneration, 2. the ability to repair nucleic acids, 3. the concentration of tissue specific proteins (chalones) inhibiting cell proliferation and tumor growth, 4. the increase of metabolism before and during cancerization, 5. the unspecific mesenchymal reaction, 6. the immunologic response against tumor cells, 7. the reactions on radiotherapy, 8. the affinity of tissue to chemical carcinogenic substances.
D002471:Cell Transformation, Neoplastic; D004260:DNA Repair; D004428:Ear Neoplasms / Q000209:etiology*; D006131:Growth Inhibitors / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology*; D009361:Neoplasm Invasiveness; D009365:Neoplasm Regression, Spontaneous; D012142:Respiratory Tract Neoplasms / Q000209:etiology*
D006131:Growth Inhibitors
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