[Synthesis of a fragment of the active center of the streptococcal proteinase (EC 3.4.22.10), VIII (author's transl)].
The synthesis of the protected tricosapeptide Z-Val-Lys(Z)-Pro-Gly-Glu(OBzl)-Gln-Ser-Phe-Val-Gly-Gln-Ala-Ala-Thr-Gly-His-Cys(MBzl)-Val-Ala-Thr-Ala-Thr-Ala-ONB is described. The tricosapeptide was built up from the decapeptide Z-Val-Lys(Z)-Pro-Gly-Glu(OBzl)-Gln-Ser-Phe-Val-Gly-ONp and the tridecapeptideester Gln-Ala-Ala-Thr-Gly-His-Cys(MBzl)-Val-Ala-Thr-Ala-Thr-Ala-ONB. A further nonadecapeptide with tert-butylmercapto protection of the SH group was also synthetized.
D001665:Binding Sites; D010450:Endopeptidases; D010446:Peptide Fragments / Q000138:chemical synthesis*; D013291:Streptococcus / Q000201:enzymology*
D010446:Peptide Fragments; D010450:Endopeptidases
Synthese einer Partialsequenz aus dem aktiven Zentrum der Streptokokken-Proteinase (EC 3.4.22.10), VIII