[Reactivity of the liver to administration of cholic acid to rats subjected to polychloropinene expsoure for a long time].
It was found that in healthy rats cholic acid caused a moderately increased intensity of bile secretion and raised the content of bile acids in it. In animals with toxic hepatitis produced by a long-term action of the chemical poison polychlorpinene in a dose of 1/10 DL50 and following introduction to such rats of cholic acid in a dose of 30 mg/100 g an intensified elinination of cholates and cholesterol excretion were evident. Combined action of polychlorpinene and cholic acid was conductive to a reduced conjugation of cholic acid with taurine and to a greater conjugation with glycine, this being attended by an increased content of free bile acids in the bile.
D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D002793:Cholic Acids / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D051381:Rats; D013729:Terpenes / Q000506:poisoning*
D002793:Cholic Acids; D007306:Insecticides; D013729:Terpenes; D002784:Cholesterol
Reaktivnost' pecheni na vvedenie kholevoĭ kisloty u krys, podvergavshikhsia dlitel'nomu vozdeĭstviiu polikhlorpinena.