On the identity of lymphoid cells that stimulate the rat MLC and produce active enhancement.
The preimmunization of 10(7) Brown Norway (BN) rat lymphoid cells i.v. 1 week before (Lew X BN) F1 to Lewis renal grafting causes a state of immunologic enhancement. The BN lymphoid cells responsible for producing enhancement are the same cells that are capable of stimulating Lewis T cells in one-way MLCs. Thus active enhancement requires immunity to LD antigens, since SD +, LD- BN cells do not create a vigorous enhanced state.
D000818:Animals; D006085:Graft Survival; D006649:Histocompatibility Antigens; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens