title: [The effect of hypertonic solutions on the electrical activity of isolated frog muscle spindles].
abstract: Electrical activity of an isolated frog muscle spindle was investigated in hypertonic solutions obtained by adding 400 mM of sucrose, glucose or glycerine to the Ringer solution. In sucrose and glucose hypermedia the frequency of background impulse activity first increased and then decreased up to zero; receptor potentials and evoked impulse activity simultaneously decreased and disappeared. In the glycerine hypermedia impulse activity after some increase returned to normal and then a second rise of frequency to a constant supernormal level was observed. After returning to the Ringer solution from sucrose or glucose the background and evoked impulse activity progressively returned to normal. But after glycerine hypermedia a significant growth in the background impulse activity and a small change in frequency of evoked impulse activity were observed. The observed changes of electrical activity of the muscle spindle in hypermedia are discussed in terms of deformation of sensory endings and intrafusal muscles fibres leading to depolarization of the receptor membrane.
mesh_terms: D000818:Animals; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology; D005990:Glycerol / Q000494:pharmacology; D006982:Hypertonic Solutions / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009470:Muscle Spindles / Q000187:drug effects / Q000502:physiology*; D009997:Osmotic Pressure; D013395:Sucrose / Q000494:pharmacology
chemical_list: D005950:Glucose Solution, Hypertonic; D006982:Hypertonic Solutions; D013395:Sucrose; D005990:Glycerol
vernacular_title: Vliianie gipertonicheskikh rastvorov na élektricheskuiu aktivnost' izolirovannogo myshechnogo veretena liagushki