Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.
J.H., an HLA-Dw2 homozygous multiparous woman, fails to respond to her husband, W.H. (HLA Dw1,-) in the unidirectional mixed lymphocyte reaction. T cells from J.H. were previously shown to suppress the responses of Dw2-positive cells but not Dw2-negative cells to W.H. We now report that a soluble factor released into the supernate of the mixed lymphocyte reaction by J.H. T cells, mediates this suppression. Like the cell from which it is derived, the factor is highly specific for HLA Dw2 in the responder cell and partially specific for the stimulatory alloantigen.
D000918:Antibody Specificity; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007959:Lymphocyte Culture Test, Mixed; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens