Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion.
The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg +/- 0.3. Maximum blood flows occurred 111 min +/- 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.6 pg/ml to 115 pg/ml (P less than 0.001). Estriol was not detected.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology* / Q000502:physiology; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000096:biosynthesis*; D004970:Estrone / Q000097:blood; D005260:Female; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014513:Ureter / Q000098:blood supply*
D004967:Estrogens; D004970:Estrone; D003687:Dehydroepiandrosterone; D004958:Estradiol