Synaptosomal adenosine triphosphatase (ATPase) inhibition by organophosphates.
Chicken spinal cord adenosine triphosphatases (both Na+, K+ stimulated and ouabain insensitive) were inhibited by tri-o-tolyl phosphate (TOTP, a neurotoxic organophosphate which is not a cholinesterase inhibitor) and mevinphos (a non-neurotoxic compound but inhibitor of cholinesterases). The inhibition was concentration and time dependent, with an initial rapid drop in activity followed by a gradual exponential decline.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D003408:Cresols / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008799:Mevinphos / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013116:Spinal Cord; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*; D014317:Tritolyl Phosphates / Q000494:pharmacology*
D003408:Cresols; D007306:Insecticides; D014317:Tritolyl Phosphates; D008799:Mevinphos; D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium