[Structural and functional changes in myosin in chronic coronary insufficiency].
A study of myosin extracted from dog's cardiac muscle at different stages of chronic heart failure (from 1 week to 1 year) was carried out. A decrease of UV-luminescence intensity, flow birefringence and ATPase activity (to 70%) was observed. The electron microscopic investigation of myosin and LMM structure shows the loss of ability to form typical paracrystals by LMM, the electron microscopic appearance of the whole myosin being unchanged.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004285:Dogs; D006333:Heart Failure / Q000201:enzymology / Q000473:pathology; D009218:Myosins / Q000378:metabolism
D000251:Adenosine Triphosphatases; D009218:Myosins
Strukturnye i funktsional'nye izmeneniia miozina pri khronicheskoĭ nedostatochnosti serdtsa