T and B lymphocytes in patients with Down's syndrome.
Individuals with Down's syndrome are thought to have abnormalities of immune function. Studies to quantify the number of peripheral blood T and B lymphocytes and serum immunoglobulins in 12 individuals and 12 sex and age matched control subjects were performed. Hepatitis B antigen and antihyroglobulin antibodies as markers of possible immune dysfunction were determined. The numbers of circulating T and B cells, and the level of serum immunoglobulins in children with Down's syndrome did not differ from nonretarded control children. Circulating hepatitis B antigen and antihyroglobulin antibodies were not present. These studies indicated that quantitative abnormalities of T and B cells are not present in children with Down's syndrome. The data did not exclude the existence of qualitative abnormalities.
D000906:Antibodies / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D004314:Down Syndrome / Q000150:complications / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000150:complications / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D012737:Sex Factors; D013601:T-Lymphocytes / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology
D000906:Antibodies; D006511:Hepatitis B Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013954:Thyroglobulin