title: Efficacy of lincomycin and spectinomycin on canine pathogens.
abstract: Lincomycin (L), spectinomycin (S), and both (L-S) were evaluated in vitro and vivo against canine pathogens. In vitro, a wider spectrum of antimicrobial activity was achieved with L-S than with either L or S. The therapeutic effects of the antibiotics were investigated in 36 dogs inoculated with a mixture of the microbal agents. Tonsillitis, conjunctivitis, laryngitis, abscess formation, and necropsy findings were measured. The L-S combination was effective for the treatment of tonsillitis, conjunctivitis, laryngitis, and pneumonia in dogs.
mesh_terms: D000038:Abscess / Q000662:veterinary; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007827:Laryngitis / Q000662:veterinary; D008034:Lincomycin / Q000494:pharmacology / Q000627:therapeutic use*; D009174:Mycoplasma / Q000187:drug effects; D009175:Mycoplasma Infections / Q000662:veterinary; D010326:Pasteurella Infections / Q000662:veterinary; D011014:Pneumonia / Q000662:veterinary; D000198:Spectinomycin / Q000494:pharmacology / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000662:veterinary; D013290:Streptococcal Infections / Q000662:veterinary; D014069:Tonsillitis / Q000662:veterinary
chemical_list: D000198:Spectinomycin; D008034:Lincomycin