Cardiac function in the chronically volume-overloaded canine heart.
In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dtmax at comparable load is elevated, while later (10 weeks of AV-block) when stable hypertrophy is present, contractility becomes again normal, In the hypertrophied heart a non-depressed cardiac performance and contractility and functional reserve was established from insitu experiments and from evaluations in the isolated heart.
D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology*; D002908:Chronic Disease; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D006327:Heart Block / Q000503:physiopathology; D009200:Myocardial Contraction; D013997:Time Factors