Impaired dopamine function and muscular rigidity induced by 6-aminonicotinamide in rats.
In corpus striatum, 6-aminonicotinamide (6-AN), 10 mg/kg i.p. lowered the concentration of dopamine and markedly reduced the disappearance of dopamine after synthesis inhibition with alpha-methyl-p-tyrosine. In the dopamine-rich part of the limbic system, the formation of DOPA after decarboxylase inhibition with 3-hydroxybenzylhydrazine was decreased. In diencephalon, 6-AN altered neither the steady-state level nor the utilization of noradrenaline. The data suggest that the muscular rigidity induced by 6-AN may be associated with disruption of dopaminergic transmission.
D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D006834:Hydrazines / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009127:Muscle Rigidity / Q000139:chemically induced*; D009536:Niacinamide / Q000031:analogs & derivatives*; D051381:Rats; D013997:Time Factors
D002395:Catecholamines; D006834:Hydrazines; D008781:Methyltyrosines; D009536:Niacinamide; D015120:6-Aminonicotinamide; D004298:Dopamine