title: [Oral aphthoid toxic dermatoses].
abstract: In a description of 4 cases (phenindione, 1 case; niflumic acid, 1 case; gold salts, 2 cases), the authors describe a new variety of oral toxicodermatitis characterized by an eruption of painful, infiltrated aphthoid ulcerations, not precededbybull ae, small (less than 1 cm), roundish, with a greyish yellow necrotic centre surrounded by an erythematous halo. Histological investigation reveals a compact, polymorphous inflammatory infiltrate with numerous polynuclear neutrophiles or, less commonly, eosinophiles some of which are in a state of pyknosis of leukocytoclasia, associated with phenomena of spongiosis or necrosis of the epithelium.
mesh_terms: D000328:Adult; D000368:Aged; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006046:Gold / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009544:Niflumic Acid / Q000009:adverse effects; D010630:Phenindione / Q000009:adverse effects; D012492:Salts; D013281:Stomatitis, Aphthous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D012492:Salts; D009544:Niflumic Acid; D010630:Phenindione; D006046:Gold
vernacular_title: Toxidermies buccales aphtoïdes