Influence of corticosteroids on connective tissue.
All glucocorticosteroids inhibit growth, regeneration and repair of cellular or intercellular components of dermal connective tissues, when penetrated through the skin barrier. The resulting atrophy is a logical manifestation of the action of these compounds.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001284:Atrophy; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis; D003238:Connective Tissue / Q000187:drug effects*; D003875:Drug Eruptions / Q000209:etiology; D005347:Fibroblasts / Q000187:drug effects; D005938:Glucocorticoids; D006854:Hydrocortisone; D008264:Macrophages / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects; D051381:Rats; D012038:Regeneration / Q000187:drug effects; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D003094:Collagen; D006854:Hydrocortisone