Improvement by chlorine of the intestinal absorption of inorganic and organic Mg compounds and of their protective effect against adrenergic cardiopathy.
Comparative studies on the therapeutic effects of MgSO4, MgCl2, Mg aspartate, and Mg aspartate hydrochloride were carried out in Sprague-Dawlwy rats. In general, the intestinal absorption of Mg and its uptake into bone were improved after oral or intraduodenal administration of the two compounds containing chlorine; however, in these animals, gain in body weight was reduced, especially after MgCl2. Treatment with 9-alpha-fluorocortisol plus epinephrine resulted in cardiac hypertrophy and necroses. All Mg compounds fed in amounts leading to marked hypermagnesemia prevented hypertrophy; as regards the incidence and severity of necroses, however, MgSO4 and Mg aspartate proved ineffective. Significant protective effects were observed only after MgCl2 and Mg aspartate hydrochloride, indicating the central pathogenic role of extracellular hypochloremic alkalosis in metabolic heart necroses.
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D006332:Cardiomegaly / Q000517:prevention & control; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000517:prevention & control*; D002712:Chlorides / Q000378:metabolism / Q000627:therapeutic use; D004837:Epinephrine / Q000494:pharmacology; D006851:Hydrochloric Acid / Q000378:metabolism / Q000627:therapeutic use; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007408:Intestinal Absorption; D008274:Magnesium / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D008278:Magnesium Sulfate / Q000378:metabolism / Q000627:therapeutic use; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats
D002712:Chlorides; D001224:Aspartic Acid; D008278:Magnesium Sulfate; D008274:Magnesium; D006851:Hydrochloric Acid; D002118:Calcium; D006854:Hydrocortisone; D004837:Epinephrine