The effect of cycloheximide on mouse learning.
Mice were trained in an avoidance learning task. The incorporation of 3H-leucine into the hippocampal regions of trained mice was higher than that of control mice. When mice were injected with cycloheximide, a strong inhibitor of protein synthesis, impairment was evident in acquisition of learning. Cycloheximide produced morphological changes in mitochondria and microtubules of some brain axons. It is suggested that the cycloheximide-induced learning impairment may be due to the blocking of the synthesis of the specific protein necessary of neutral conductivity.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D003513:Cycloheximide / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D007930:Leucine / Q000378:metabolism; D051379:Mice; D008933:Mitochondrial Swelling / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000096:biosynthesis
D009419:Nerve Tissue Proteins; D003513:Cycloheximide; D007930:Leucine