Glycolytic end products of the adult dog heartworm, Dirofilaria immitis.
1. Adult dog heartworms remained alive and motile for 24 hr without oxygen present and with only glucose available as a substrate. 2. Lactate accounted for 55% of the carbon from the 1-14C-glucose utilized in 1 hr and 14CO2 for 1.9%. 3. Only traces of 14C were found in glycogen and no net accumulation of acetate was demonstrated. 4. Dirofilaria immitis resembles Litomosoides carinii in the percent of utilized glucose appearing as lactate but is more akin to Brugia pahangi and Dipetalonema viteae in survival under anaerobic conditions and in negligible acetate production.
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004183:Dirofilaria immitis / Q000378:metabolism*; D005370:Filarioidea / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis; D007700:Kinetics; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D010100:Oxygen / Q000494:pharmacology
D000085:Acetates; D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D006003:Glycogen; D005947:Glucose; D019342:Acetic Acid; D010100:Oxygen