[Study of the active calcium transport mechanisms in uterine smooth muscle].
Calcium ions were shown to be actively accumulated in mitochondrial and microsomal fractions of uterine smooth muscle of rabbit and cattle. In presence of magnesium ions Ca2+ (10-6-10-4 M) activate microsomal ATPase from cattle uterus. The rate of formation and dissociation of the intermediate phosphorylated substance of Mg2+, Ca2+-ATPase was found to be lower in microsomes of smooth muscles than in sarcoplasmic reticulum of sceletal muscles. Serotonine (concentration 10-6 M) increased the dissociation of the intermediate phosphorylated substance from microsomes of uterine smooth muscle and decreased their capacity to bind Ca2+. At the same concentration serotonine inhibited the ATP-dependent accumulation of 45Ca by microsomes of uterine smooth muscle.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002417:Cattle; D005260:Female; D008861:Microsomes / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology; D014599:Uterus / Q000378:metabolism
D002132:Calcium Radioisotopes; D012701:Serotonin; D000251:Adenosine Triphosphatases; D002118:Calcium
Izuchenie aktivnykh mekhanizmov transporta kal'tsiia v gladkoĭ myshtse matki