A multifactorial system controlling myeloid cell differentiation and division.
It has been demonstrated that mature granulocytes contain two stimulatory and three inhibitory factors of cell proliferation. Consequently, beyond the negative feedback inhibitor (chalone), myeloid cells are controlled presumably by other negative (inhibitory) and positive (stimulatory) mechanisms, in addition.
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002458:Cell Fractionation; D002850:Chromatography, Gel; D006098:Granulocytes / Q000378:metabolism; D006131:Growth Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology*; D008940:Mitotic Index; D011817:Rabbits; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D006131:Growth Inhibitors; D006133:Growth Substances; D013936:Thymidine