Antimicrobial effectiveness of Locacorten-Vioform cream in Secondary infections of common dermatoses.
In a double-blind study involving 430 patients, Locacorten (0.02%)-Vioform (3%) cream was found to be highly effective in the treatment of dermatological conditions complicated by secondary bacterial involvement. Themicrobiological conversion and clinical improvement in patients treated with Locacorten-Vioform combinations were markedly greater than those achieved in the groups medicated with (1) Vioform 3%, (2) Locacorten 0.02%, and (3) placebo cream. Staphylococcus aureus was the most prevalent organism isolated from the skin lesions. All strains were sensitive to Vioform, as compared to 62% found to be resistant to other antimicrobials.
D000287:Administration, Topical; D003883:Arthrodermataceae / Q000302:isolation & purification; D002179:Candidiasis, Cutaneous / Q000188:drug therapy; D002986:Clinical Trials as Topic; D007464:Clioquinol / Q000008:administration & dosage / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005443:Flumethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010919:Placebos; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy; D013997:Time Factors
D010919:Placebos; D007464:Clioquinol; D005443:Flumethasone