Contribution of monofunctional adducts formed by furocoumarins with DNA to the inhibition of nucleic acids synthesis.
In addition to the bifunctional adducts (cross-linkages), that furocoumarins on radiation at 365 nm form in DNA, monofunctional adducts also proved able to inhibit the nucleic acid synthesis in Ehrlich ascites tumor cells.
D002460:Cell Line; D003374:Coumarins / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D005363:Ficusin / Q000494:pharmacology; D011564:Furocoumarins; D010777:Photochemistry; D012313:RNA / Q000096:biosynthesis*; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
D003374:Coumarins; D011564:Furocoumarins; D012313:RNA; D004247:DNA; D005363:Ficusin