Carcinogenic activity of anthanthrene on mouse skin.
Dibenzo [cd,jk] pyrene (anthanthrene), considered to be noncarcinogenic, was examined for carcinogenicity in a comparative study with other polycyclic hydrocarbons. Anthanthrene induced benign and malignant epidermal neoplasms in female Swiss mice after repeated skin application. The incidence of these tumors (47%) was lower and the latency longer than those found after benzo[a]pyrene or dibenzo[a,h]pyrene treatment. Since the proportion of malignant neoplasms was similar (60%) in these three groups, the results indicate that anthanthrene is a relatively strong carcinogen. A rationale accounting for previous negative results in percutaneous experiments with this compound is suggested.
D000818:Animals; D001580:Benzopyrenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D007636:Keratoacanthoma / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*
D001580:Benzopyrenes