[The effect of cocaine treatment on the level of dopamine and serotonin regeneration and on the level of acetylcholine in rat brain].
Cocaine treatment (10 or 50 mg/kg, i.m.): 1) did not change significantly the amount of 3H dopamine synthesized from 3H tyrosine in the striatum but reduced the specific activity of 3H tyrosine; 2) delayed the release of cerebral dopamine after inhibition of its biosynthesis by alpha-methylparatyrosine; 3) reduced the amount of 5-hydroxyindolacetic acid accumulated after Probenecid, which reflects an inhibitory effect on serotonin release; 4) did not change significantly the acetylcholine level of the brain.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000096:biosynthesis* / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis*; D014443:Tyrosine / Q000378:metabolism
D008781:Methyltyrosines; D012701:Serotonin; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D003042:Cocaine; D000109:Acetylcholine; D011339:Probenecid; D004298:Dopamine
Influence du traitement par la cocaïne sur le taux de renouvellement de la dopamine et de la sérotonine et le taux d'acétylcholine du cerveau de rat