Morphological study of the thymus of Jensen tumor-bearing rats after tumoral, non-tumoral antigens and thiamine diphosphate administration.
The morphological changes produced in the thymus of Jensen tumor-bearing rats after specific immune stimulation (glycoprotein 8 obtained from Jensen tumor, bovine serumalbumin (BSA), tuberculoprotein, gylcoprotein 5 from normal rat blood) and after non-specific one (thiamine diphosphate (TDP)) were studied. The changes produced by associating the antigenic action and TDP were reviewed, too. Morphological investigations were preformed 24 hours and 7 days after beginning of treatments. Twenty-four hours and 7 days after specific (tuberculoprotein and BSA) or non-specific (TDP) stimulation, similar morphologic changes were observed in the thymus: vasodilatation, thymocyte agglomeration in perivascular sheaths and their intravascular migration. When TDP was associated with gylcoprotein 8 or tuberculin - PPD more pronounced morphological modifications were observed 24 hours after treatment, while associating it with glycoprotein 5 or BSA obvious changes have been produced after 7 days. Gylcoprotein 5 and 8 did not induced any modifications in the thymus structure.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology; D013831:Thiamine / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology*; D014373:Tuberculin / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; D010710:Phosphates; D010852:Picrotoxin; D012710:Serum Albumin, Bovine; D013331:Strychnine; D013831:Thiamine; D014373:Tuberculin