[High-altitude pulmonary hypertension and fibrinolysis].
The fibrinolytic system of the blood was studied in 49 indigenous residents at an altitude of 3600 m above sea level having signs of altitude pulmonary hypertension, and in 48 persons without such signs. The control group comprised 70 residents of Dushanbe (810 m above sea level). Persons with altitude pulmonary hypertension were found to have an increased fibrinolytic activity, a reduced content of antiplasmins and inhibitors of plasminogen activation. These changes are combined with a reduction of the fibrinogen content and a decrease in the activity of the fibrin-stabilizing factor. No principal difference was found in the fibrinolytic system of comparable groups having signs of altitude pulmonary hypertension, and without such signs.
D000293:Adolescent; D000328:Adult; D000532:Altitude Sickness / Q000097:blood*; D005341:Fibrinolysin / Q000032:analysis / Q000037:antagonists & inhibitors; D005342:Fibrinolysis; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology; D000860:Hypoxia / Q000097:blood*; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D012800:Siberia
D010958:Plasminogen; D005341:Fibrinolysin
Vysotnaia legochnaia gipertoniia i fibrinoliz