Lipogenesis by intact hepatocytes from normal and diabetic rats.
Intact hepatocytes isolated from livers of diabetic rats demonstrate the characteristic decreased lipogenic capacities as compared to normal. Administration of insulin to diabetic rats restores these capacities to near normal levels. The results emphasize the potential that the hepatocyte system has for the study of hormonal regulation of lipogenesis.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D066298:In Vitro Techniques; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D013311:Streptozocin
D000085:Acetates; D001786:Blood Glucose; D005227:Fatty Acids; D008055:Lipids; D013311:Streptozocin; D002784:Cholesterol