On the mechanism of activation of CaATPase by a single univalent cation.
It has been demonstrated with ox-brain microsome membranes that the mechanism of CaATPase activation by a single univalent cation is different in case of Na+-ont he one hand-and K+ and its congeners-on the other. Whereas Na+ increases the amount of 32-P protein (phosphorylated intermediate), K+ causes only an insignificant increase or decrease compared to the Ca-2+-containing sample. Our findings support the assumption that the altered activity of the Na-K-ATPase (modified by the presence of Ca-2+) is responsible for the univalent cation activation of the CaATPase.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002118:Calcium / Q000494:pharmacology*; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D007700:Kinetics; D008566:Membranes / Q000187:drug effects* / Q000201:enzymology*; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D011188:Potassium / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology*; D013997:Time Factors
D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium; D002118:Calcium