[Effect of noradrenaline on transport adenosine triphosphatase in the cerebral synaptosomes of Citellus erythrogenus susliks].
The effect of noradrenalin (0.5 mM) on the activity of Na, K-ATPase and Mg-ATPase has been investigated in active and hibernating ground squirrels. ATPase activities were determined in vitro at 37 and 17 degrees. The inhibitory effect of noradrenalin was found on Na, K-ATPase in non-hibernating summer animals. It was most significant at the beginning of summer, i. e. at the period of highest physiological activity of animals, and lowered to the end of summer. No significant influence of noradrenalin on the activity of Mg-ATPase was found. In hibernating ground squirrels, noradrenalin inhibited Na, K-ATPase and activated Mg-ATPase of synaptosomes incubated at 37 degrees, but produced no effect at 17 degrees, i.e. at the temperature closer to that during hibernation.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D006605:Hibernation; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012377:Rodentia / Q000378:metabolism*; D012589:Sciuridae / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology; D013696:Temperature
D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium; D009638:Norepinephrine
Deĭstvie noradrenalina na transportnuiu adenozintrifosfatazu sinaptosom mozga u suslika Citellus erythrogenus.