title: Calcium uptake and ATPase activity of microsomes from heterotopically transplanted rabbit heart.
abstract: Heterotopic cardiac transplantation was performed in rabbits. The calcium uptake and ATPase activities of microsomal fraction were studied in three groups (group I, normal controls; group II, early transplants; group III, late transplants) during severe rejection as characterized histologically and electrocardiographically. Group III showed a significant decrease in calcium uptake but no difference in ATPase activity compared with groups I or II. The results demonstrate that in the rejecting transplanted hearts there is an uncoupling of microsomal calcium uptake from this ATP splitting function.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002474:Cell-Free System; D006084:Graft Rejection / Q000378:metabolism* / Q000473:pathology; D016027:Heart Transplantation; D008861:Microsomes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D011817:Rabbits; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D000251:Adenosine Triphosphatases; D002118:Calcium