[Effect of tetanus toxin and colchicine on synaptic membranes of rat cerebral cortex].
It was shown that purified tetanus toxin did not influence the activity of the Na, K-ATP-ase fractions of the synaptic membranes of the rat cerebral cortex, it had no effect on the inhibition of Na, K,-ATP-ase under electrical stimulation of the synaptic membrane suspension, or the GABA--3H binding by the synaptosomes in vitro. Tetanus toxin (400--4000 DLM) and colchicine (1 mM) induced a decrease of osmotic sensitivity of the nerve endings. Colchicine in low concentrations (10(-5)-10(-3) M) failed to influence Mg-and Na, K-ATP-ases, but considerably inhibited both ATP-ases at higher concentrations.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure*; D003078:Colchicine / Q000494:pharmacology*; D008274:Magnesium; D009996:Osmotic Fragility / Q000187:drug effects; D011188:Potassium; D051381:Rats; D012964:Sodium; D013570:Synaptic Membranes / Q000187:drug effects* / Q000201:enzymology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D013744:Tetanus Toxin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D013744:Tetanus Toxin; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium; D003078:Colchicine
Deĭstvie stolbniachnogo toksina i kolkhitsina na sinapticheskie membrany kory mozga krys