[Antigenic and blood group activity of lamb gastric mucoproteins].
The antigenic properties of a lamb mucin and of a glycoprotein isolated from it are investigated. The proteins are studied by immunoelectrophoresis of the mucin and of the glycoprotein against either a sheep serum antiserum or an exclusively glycoprotein antiserum. No serum protein could be shown in the mucin. In addition, the glycoprotein gives a precipitin line only with the specific antiserum; its antigenic power seems to be concealed in the original mucin. The carbohydrates are studied through the investigation of the blood group activities by the hemagglutination inhibition technique. The mucin and the isolated glycoprotein show the same types of activities: they both prevent the agglutination of A1 and 0 red cells. The presence of two blood group activities in that glycoportein and its non-reactivity against A2 red cells corroborate the hypothesis that carbohydrate chains must be branched for the elicitation of these activities in a single molecule.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000941:Antigens; D001789:Blood Group Antigens; D006385:Hemagglutination Inhibition Tests; D007122:Immunoelectrophoresis; D009088:Mucoproteins / Q000276:immunology*; D012756:Sheep
D000596:Amino Acids; D000941:Antigens; D001789:Blood Group Antigens; D009088:Mucoproteins
Etude de l'activité antigénique et groupe sanguin de mucoproteines gastriques d'agneau