Activation of human Glu-plasminogen to Glu-plasmin by urokinase in presence of plasmin inhibitors. Streptomyces leupeptin and human plasma alpha1-antitrypsin and antithrombin III (plus heparin).
D000991:Antithrombins / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D005973:Glutamine; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007976:Leupeptins / Q000494:pharmacology*; D008239:Lysine; D009842:Oligopeptides / Q000494:pharmacology*; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators; D013302:Streptomyces; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*
D000991:Antithrombins; D007976:Leupeptins; D009842:Oligopeptides; D000515:alpha 1-Antitrypsin; D005973:Glutamine; D010958:Plasminogen; D006493:Heparin; D010960:Plasminogen Activators; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; D008239:Lysine