[The effect of various substances on the time of survival of rabbits under conditiones of oxygen-delay (author's transl)].
In 30 rabbits, which had accidentally been divided into five groups of different treatment the effect of the substance Persantin, Actihaemyl and Noleptan was investigated in view of the time of survival of the animals and the behaviour of the acid-base-balance and the blood-gases under conditions of oxygen-delay. There were two control-groups. One collective was treated with Haemaccel, the other with Glucose. In those groups treated with Persantin, Actihaemyl and Noleptan the time of survival of the animals is significantly higher in comparison with the animals of the control-groups. The behaviour of the acid-base-balance and the blood-gases in the collective treated with Persantin points to a reduction of the dimension of the metabolic acidosis. This effect cannot be assumed for Actihaemyl because of this investigation. The effect of Noleptan seems to depend on an improvement of the gas exchange in the lungs of the rabbits. The results of this investigation show that the application of Persantin and Actihaemyl might be an interesting enrichment of the medicamental treatment of the intrauterine acidoses.
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000188:drug therapy; D000183:Actihaemyl / Q000627:therapeutic use*; D000818:Animals; D001237:Asphyxia / Q000188:drug therapy*; D001784:Blood Gas Analysis; D004176:Dipyridamole / Q000627:therapeutic use*; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D000860:Hypoxia / Q000150:complications*; D009025:Morpholines / Q000627:therapeutic use*; D011097:Polygeline / Q000627:therapeutic use; D011817:Rabbits; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use*
D009025:Morpholines; D014020:Tissue Extracts; D000183:Actihaemyl; D004176:Dipyridamole; D011097:Polygeline; D005947:Glucose
Die Wirkung verschiedener Substanzen auf die Uberlebenszeit von Kaninchen unter Sauerstoffmangelbedingungen