[Importance of the fibrinogen-heparin complex in the fibrinolytic activity of the blood euglobulin fraction after the intravenous administration of thrombin or plasmin].
Intravenous administration of plasmin as distinct from thrombin inhibited or did not provide a secretion of endogenous heparin into circulation. In these conditions non-enzymatic fibrinolysis was not observed both in fraction of euglobulins and in fibrinogen-heparin complex, isolated from euglobulins, due to insufficiency of heparin. Exogenous heparin, injected into circulation or added to corresponding fractions, enabled to produce the active heparin complexes. About 70% of total fibrinolytic activity was due to fibrinogen-heparin complex in euglobulin fraction of blood plasma, isolated from blood of animals intravenously administered with thrombin.
D000818:Animals; D004338:Drug Combinations; D005340:Fibrinogen / Q000502:physiology*; D005341:Fibrinolysin / Q000008:administration & dosage*; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000502:physiology*; D006494:Heparin Antagonists; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D012712:Serum Globulins / Q000502:physiology*; D013917:Thrombin / Q000008:administration & dosage*
D004338:Drug Combinations; D006494:Heparin Antagonists; D012712:Serum Globulins; D005340:Fibrinogen; D006493:Heparin; D013917:Thrombin; D005341:Fibrinolysin
Znachenie kompleksa fibrinogen-geparin v fibrinoliticheskoĭ aktivnosti éuglobulinovoĭ fraktsii krovi posle vnutrivennogo vvedeniia trombina ili plazmina.