title: The effect of cancer chemotherapy on lysosomal enzymic activities (acid phosphatase) of Ehrlich ascites carcinoma cells.
abstract: The distribution of acid phosphatase in Ehrlich ascites carcinoma cells was studied by histochemical techniques in mice treated with antitumoral agents (Tio-Tepa, Cosmegen). The results proved the accuracy of the histoenzymatic demonstration of APh activity for the study of early changes induced in Ehrlich ascites tumor by antitumoral drugs : these changes precede those revealed by routine histological methods and are related to the degree of sensitivity of the tumor to the drugs.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000201:enzymology*; D002478:Cells, Cultured; D003609:Dactinomycin / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008247:Lysosomes / Q000201:enzymology*; D051379:Mice; D013852:Thiotepa / Q000627:therapeutic use*
chemical_list: D003609:Dactinomycin; D013852:Thiotepa; D000135:Acid Phosphatase