Simultaneous occurrence of diabetes, liver cirrhosis, and 47, XX,21 +/46, XX chromosomal pattern.
A girl with juvenile diabetes, liver cirrhosis, and 47,XX,21 +/46,XX chromosomal mosaicism is described. The immunoglobulin pattern suggested an autoimmune process. After prednisolone treatment the IgG level and liver function tests became normal and the liver histology improved.
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D004314:Down Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology