The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice.
The level and avidity of anti-DNA antibody in the serum of New Zealand Black/White (NZB/W F1) hybrid mice has been determined. The results show that there is an age and sex-related variation in the avidity of this antibody. In mice of both sexes, the avidity of circulating anti-DNA antibody increases up to 5 months of age; thereafter the avidity falls with increasing age. These variations are more marked in males, but female mice consistently have lower avidity anti-DNA antibody than males. Thus the time of onset, time course and severity of the murine lupus syndrome in NZB/W F1 mice are associated with the presence of increasing levels of low avidity anti-DNA antibody in the serum. These results are discussed in the context of the possible role of low avidity antibody in immune complex disease.
D000375:Aging; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity / Q000187:drug effects; D004247:DNA / Q000276:immunology*; D003839:Deoxyadenosines / Q000494:pharmacology; D005260:Female; D006824:Hybridization, Genetic; D007105:Immune Complex Diseases / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007158:Immunologic Techniques; D007201:Indicator Dilution Techniques; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D012737:Sex Factors
D000906:Antibodies; D003839:Deoxyadenosines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004247:DNA