Normal and 6-aminonicotinamide impaired development of capillarization in occipital cortex of rat.
During different embryonic and postnatal stages, 6-aminonicotinamide (6-AN) was administered to Wistar albino rats. The capillarization of the occipital cortex has been examined morphometrically. A 6-AN-vulnerable stage of prenatal development was found, which lasted to the 19th prenatal day and which only partly corresponds to the so-called 'critical stage' of capillary sprouting (Kapillarsprossung). Capillary sprouting was not impaired by 6-AN during postnatal stages. Impairment of capillarization by 6-AN might be the result of glial lesion. The importance of glia for capillarization is discussed.
D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000254:growth & development*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000187:drug effects / Q000196:embryology; D009457:Neuroglia; D009536:Niacinamide / Q000031:analogs & derivatives*; D009778:Occipital Lobe / Q000098:blood supply* / Q000187:drug effects / Q000196:embryology; D051381:Rats
D009536:Niacinamide; D015120:6-Aminonicotinamide