Audiogenic seizures in mice: influence of agents affecting brain serotonin.
Brain serotonin levels and susceptibility to audiogenic seizures were examined in a strain of inbred audiosusceptible mice and in control mice at intervals from two hours to one week after treatment with several agents known to modify serotonin metabolism. Although p-chlorophenylalanine produced a gradual decrease in brain serotonin there appeared to be no temporal correlation between this effect and the rapid reduction in seizure susceptibility. 5-Hydroxytryptophan and tranylcypromine led to significant increases in serotonin, but only the former caused a proportinal reduction in seizure activity. Reserpine and alpha-propyldopacetamide decreased serotonin levels but only reserpine caused an intensification of seizure activity proportional to serotonin changes. On the basis of our data, effects of 5-hydroxytryptophan and reserpine on seizure susceptibility appear to be linked to observed brain serotonin levels; further studies are needed to elucidate the mode of action of p-chlorophenylalanine.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000161:Acoustic Stimulation; D000577:Amides / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000378:metabolism*; D012701:Serotonin / Q000032:analysis*; D013997:Time Factors
D000577:Amides; D012701:Serotonin; D012110:Reserpine; D006916:5-Hydroxytryptophan; D010134:Fenclonine