[The influence of different sugar reducing preparations on several pathogenetic components of diabetic angiopathy].
On the basis of clinico-laboratory examination of 500 patients suffering from diabetes mellitus a comparison was made of the influence of treatment with insulin and sulfanilamides on disturbed metabolic processes promoting development of vascular affections.  There were found no differences in the action of insulin and oral agents on the indices of lipid, protein and mucopolysaccharide metabolism and on activity of the enzymes of the pentose-phosphate cycle.  Corticosteroid excretion normalized with the compensation of diabetes, irrespective of the type of the sugar-reducing preparations.  A more pronounced increase in catecholamine excretion was seen in insulin therapy apparently in connection with greater variations in glycemia level.  A conclusion was drawn on analogous effect of insulin and sulphanilamides on the metabolic changes under study in diabetes.  In difference from the action of insulin, a marked allergization of the of the organism accompanying the action of sulphanilamides, and their normalizing effect on the vascular permeability should be referred to the positive aspects of sulphanilamide action.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000251:Adenosine Triphosphatases / Q000097:blood; D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D002199:Capillary Permeability; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000188:drug therapy / Q000201:enzymology; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D003927:Diet, Diabetic; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000652:urine; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007328:Insulin / Q000097:blood / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D010743:Phospholipids / Q000097:blood; D013424:Sulfanilamides / Q000627:therapeutic use*; D014174:Transketolase / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014642:Vanilmandelic Acid / Q000097:blood
D015065:17-Hydroxycorticosteroids; D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D007136:Immunoglobulins; D007328:Insulin; D008055:Lipids; D010743:Phospholipids; D013424:Sulfanilamides; D014280:Triglycerides; D014642:Vanilmandelic Acid; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase; D000251:Adenosine Triphosphatases; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie razlichnykh sakharosnizhaiushchikh preparatov na nekotorye patogeneticheskie zven'ia diabeticheskikh angiopatiĭ