Conformationally restricted adenine nucleotide analogs in mitochondrial adenine nucleotide transport.
The conformationally restricted adenine nucleotide analogs 8,3'anhydro-8-oxy-9-(beta-D-xylofuranosyl)adenine-5'-O-tri(di)-phosphate (I), and 8,2'-anhydro-8-oxy-9-(beta-D-arabinofuranosyl) adenine-5'-O-tri(di)-phosphate (II), were prepared chemically as their alpha-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)P in mitochondrial adenine nucleotide translocation. The experimental findings demonstrate that the heterocycle-ribose orientation affects the carrier mediated adenine nucleotide transport very strongly, i.e. a non fixed adenine heterocycle in the anti region is prerequisite for the bound nucleotide to induce the transfer action of the adenine nucleotide carrier.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D007536:Isomerism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D008968:Molecular Conformation; D051381:Rats; D013329:Structure-Activity Relationship
D000227:Adenine Nucleotides; D002352:Carrier Proteins