Pharmacology of antitumor agents from higher plants.
Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001060:Aporphines / Q000494:pharmacology; D002166:Camptothecin / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D055598:Chemical Phenomena; D002621:Chemistry; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008453:Maytansine / Q000494:pharmacology; D008545:Melanoma / Q000188:drug therapy; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010616:Phenanthrenes / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013713:Teniposide / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D009285:Naphthoquinones; D010616:Phenanthrenes; D008453:Maytansine; D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D013713:Teniposide; D002166:Camptothecin