Photoallergic dermatitis from 8-methoxypsoralen.
A 36 year old woman with psoriasis vulgaris developed generalized photoallergic dermatitis to 8-methoxypsoralen after 16 uneventful treatments with 8-methoxypsoralen und UVA (PUVA). The diagnosis of photoallergy was confirmed by re-exposure to oral 8-methoxypsoralen and total body UVA irradiation; phototests using topical and oral 8-methoxypsoralen with a high intensity monochromator or with a new high intensity light apparatus for the delivery of UVA; and histological studies. Photoallergy occurred only with UVA, but not with UVB or UVC. There was no photoallergy following trimethylpsoralen.
D000328:Adult; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008730:Methoxsalen / Q000009:adverse effects*; D010778:Photochemotherapy / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D011565:Psoriasis / Q000188:drug therapy; D014466:Ultraviolet Rays
D008730:Methoxsalen