[Clinico-pharmacological studies on the acne-inducing action of fluocortin butylester (author's transl)].
The acne-inducing effect of butyl 6alpha-fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (fluocortin butylester, Vaspit) 0.75% was compared with that of hydrocortisone acetate 1.0% and diflucortolone valerate 0.1% in a model established by Plewig and Kligman. The steroid and the cream base uniformly used in all preparations were applied to the backs of 20 volunteers over 4 weeks. Dome-shaped red papules developed in the third week of occlusive treatment, and were counted in an area of 16 cm2 at the maximum of their development and graded according to a scale. The degree of papulation under diflucortolone valerate 0.1% was 2.15+/-0.75. No differences were observed between fluocortin butylester 0.75% (0.2+/-0.42), hydrocortisone acetate and the cream base (0.15+/-0.37).
D000152:Acne Vulgaris / Q000139:chemically induced*; D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D005448:Fluocortolone / Q000009:adverse effects* / Q000031:analogs & derivatives; D006801:Humans; D006854:Hydrocortisone; D008297:Male; D011244:Pregnadienediols / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D011244:Pregnadienediols; D005448:Fluocortolone; D006854:Hydrocortisone
Klinisch-pharmakologische Untersuchungen zur akneinduzierenden Wirkung von Fluocortin-butylester.