Data regarding the restorative effects of the partial removal of the liver in advanced stages of toxic cirrhosis.
The effects of subtotal hepatectomy of albino rats liver cirrhois at 6 and 9 months after the start of CCl4 administration were studied. The results were assessed through self-control and comparison with similar groups in which the spontaneous reversibility of cirrhotic lesions was followed. In the group of 6 months, the liver exeresis results in normalization of morphological and biochemical liver aspects within a period of one month from the intervention. In the group of 9 months, one may also note a stimulation of the regenerative capacity of parenchyma and marked collagenolytic effects without the complete restoration of the stroma/parenchyma ratio. It seems that the major exereses are also effective in the advanced stages of liver cirrosis once the threshold of spontaneous reversibility has been exceeded.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000473:pathology; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000473:pathology / Q000601:surgery*; D008115:Liver Regeneration; D008297:Male; D051381:Rats