[Effect of dexamethasone on DNA synthesis in macrophages stimulated in vitro by an inflammatory exudate].
Rat macrophages in culture are induced to synthesize DNA when incubated with Dextran pleural exudate. Previous or simultaneous in vitro treatment with dexamethasone phosphate used at different concentrations was able to inhibit or decrease that induction. This effect could represent a new aspect of the influence of corticosteroids in the inflammatory process.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D003911:Dextrans; D004305:Dose-Response Relationship, Drug; D005122:Exudates and Transudates; D007249:Inflammation / Q000503:physiopathology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats
D003911:Dextrans; D003907:Dexamethasone; D004247:DNA
Action de la déxaméthasone sur la synthèse d'ADN de macrophages stimulés in vitro par un exsudat inflammatoire.