title: Cadmium-induced experimental Fanconi syndrome.
abstract: We have demonstrated that repetitive injections of cadmium into rats leads to the abrupt development of Fanconi syndrome after the renal cortical concentration of cadmium has increased approximately eighty-fold. The syndrome is temporally associated with a fall in both Na-K-ATPase activity and ATP levels, suggesting a possible causal relationship between altered proximal tubular transport and inhibition of the ATP-Na-K-ATPase transport system.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000097:blood / Q000652:urine; D004195:Disease Models, Animal; D005198:Fanconi Syndrome / Q000139:chemically induced*; D005260:Female; D007668:Kidney / Q000378:metabolism; D007672:Kidney Cortex / Q000201:enzymology; D007677:Kidney Function Tests; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D051381:Rats
chemical_list: D002104:Cadmium; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases