title: [Problems of intracranial extension of malignant disease of the nose and sinuses (author's transl)].
abstract: Out of 424 cancers of the nasal cavities or sinuses seen at the University E.N.T. Clinic Jena, 120 had penetrated into the anterior or middle cranial fossa. The commonest of these were tumours of the upper sinuses but a fifth of all antral tumours were also involved. The favourite site of intracranial breakthrough was studied in relation to the origin of the tumour and a particular liability of antral cancers to extend to the middle cranial fossa was noted. Critical analysis of the preoperative diagnostic features showed that the extent of the tumour relative to the base of the skull was often only demonstrated by a wide external surgical exposure. Operative and electrosurgical exenteration after Zange followed by radium application to the infiltrated dura resulted in over 17% of the operated patients surviving 5 years or more without recurrences. Irradiation alone was unsuccessful in all cases. In recent years resection of the tumour has been followed by excision of the infiltrated segment of the dura and the defect covered with fascia lata. First impressions and several examples are given.
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000150:complications* / Q000175:diagnosis; D009918:Orbital Neoplasms / Q000175:diagnosis; D010255:Paranasal Sinus Neoplasms / Q000150:complications* / Q000175:diagnosis; D011379:Prognosis; D012888:Skull Neoplasms / Q000175:diagnosis*
vernacular_title: Probleme des Einbruchs der Malignome der Nase und ihrer Nebenhöhlen ins Schädelinnere