Cellular immunity to P. acnes in the normal population and patients with acne vulgaris.
Patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to P. acnes using a leukocyte migration inhibition test. Despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. It is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation.
D000152:Acne Vulgaris / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D011425:Propionibacterium acnes / Q000276:immunology*
D000942:Antigens, Bacterial