[Hemodynamic effects of various doses of a new inotropic: amrinoma].
The hemodinamic effects of Amrinone, bipiridine derivate with positive inotropic effects in animals, were studied on eight patients under right and left heart catheterization. The cardiac index, stroke volume, dP/dt and stroke work index were increased; the pulmonary pressure and the left ventricle end diastolic pressure were decreased all with statistical significant values. There were no changes in mean aortic pressure. These effects are mainly due to an increase in contractility and, partially, to vasodilation and tachycardia. The intrinsic mechanism of action of this compound is not known. Its place in cardiac therapy must be established with additional clinical investigations.
D000328:Adult; D000368:Aged; D000631:Aminopyridines / Q000008:administration & dosage / Q000494:pharmacology*; D000676:Amrinone; D006328:Cardiac Catheterization / Q000379:methods; D002316:Cardiotonic Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*
D000631:Aminopyridines; D002316:Cardiotonic Agents; D000676:Amrinone
Estudio de los efectos hemodinámicos de diferentes dosis de un nuevo inotrópico: la amrinona.