title: Further controlled evaluations of fenbendazole as a bovine anthelmintic.
abstract: The efficacy of fenbendazole (methyl-5-(phenythio)-2-benzimidazole-carbamate) in cattle parasitized by the lungworm Dictyocaulus viviparus and in other cattle parasitized by Haemonchus, Ostertagia, Trichostrongylus, Cooperia, and Oesophagostomum was investigated in 3 controlled critical experiments. A single treatment with 5.0 mg/kg of body weight administered in the feed or in a 10% suspension exceeded 99% efficacy against these helminths. Dosages of 1, 0.5, 0.35, and 0.25 mg/kg of body weight administered for 5 days to individual calves in their feed were 99% efficacious against all helminths, except Haemonchus. The 1.0 mg/kg dose removed 99.5% of the Haemonchus, and the other 3 dosages had efficacies of 91.0, 93.7, and 95.6%, respectively. The small daily dosages were not evaluated against Dictyocaulus.
mesh_terms: D000821:Animal Feed; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004022:Dictyocaulus Infections / Q000188:drug therapy; D004341:Drug Evaluation / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009814:Oesophagostomiasis / Q000188:drug therapy / Q000662:veterinary; D010029:Ostertagiasis / Q000188:drug therapy / Q000662:veterinary; D013997:Time Factors; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary; D014253:Trichostrongylosis / Q000188:drug therapy / Q000662:veterinary
chemical_list: D001562:Benzimidazoles; D005273:Fenbendazole