title: [Effect of gene dose in human cells].
abstract: Data from literature are reviewed on the gene dosage effect in human cells. Until recently the dosage effects have been distinctly shown for the genes of superoxide dismutase-1, acid phosphatase of erythrocytes, adenine phosphoribosyl transferase, glutathione reductase and nucleoside phosphorylase, located on chromosomes 21, 2, 16, 8, 14, respectively. The data are discussed in the light of problems arising from the study of the regulation of gene expression in man.
mesh_terms: D000135:Acid Phosphatase / Q000235:genetics; D000228:Adenine Phosphoribosyltransferase / Q000235:genetics; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000235:genetics; D004912:Erythrocytes / Q000201:enzymology; D005796:Genes; D005980:Glutathione Reductase / Q000235:genetics; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000235:genetics; D011683:Purine-Nucleoside Phosphorylase / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics; D014314:Trisomy
chemical_list: D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D011683:Purine-Nucleoside Phosphorylase; D000228:Adenine Phosphoribosyltransferase; D000135:Acid Phosphatase
vernacular_title: Effekt dozy gena v kletkakh cheloveka.