title: Effects of alpha methyltyrosine and parachlorophenylalanine on open field behavior in rats given tranylcypromine stereoisomers and lithium carbonate.
abstract: Parachlorophenylalanine (PCPA) and alpha methyltyrosine (AMT) were used to study the roles of serotonin and catecholamines in hyperactivity produced by the stereoisomers of Tranylcypromine (d-Tc and 1-Tc) in male Wistar rats fed a normal diet (control groups) or a diet containing lithium carbonate (lithium groups). Components of locomotor activity were measured in an open field. Lithium decreased ambulation. d-Tc increased ambulation and caused jerky side-to-side movements. PCPA and AMT prevented the effects of d-Tc on ambulation while only PCPA prevented the effects of d-Tc on movement. 1-Tc increased ambulation. The effects of 1-Tc on ambulation were potentiated by PCPA and prevented by AMT. Rearing was increased by 1-Tc and d-Tc in rats given lithium. PCPA and AMT prevented the effects of 1-Tc and d-Tc on rearing in lithium groups. The findings suggest that the roles of serotoninergic and catecholaminergic mechanisms differ for components of open field behavior in control  rats and rats given lithium.
mesh_terms: D000818:Animals; D004357:Drug Synergism; D010134:Fenclonine / Q000494:pharmacology*; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000494:pharmacology*
chemical_list: D008781:Methyltyrosines; D014191:Tranylcypromine; D008094:Lithium; D010134:Fenclonine