title: [Morphological changes in the structure of liver cell nuclei in rats with PP anitaminosis following injection of nicotinic acid].
abstract: The injection of the surplus quantities of nicotinic acid (150 mg/kg of body weight) to PP-deficient rats causes morphological changes in the structure of hepatocyte nuclei 3-6 h after the injection. These changes reach maximum by 9h, and the liver returns to its normal state by 24 h after administration. This time coincides with that of intensified new-formation of nicotinamide coenzymes (9h) and normalization of NAD content 24h in the rat liver after injection of the mentioned dose of nicotinic acid that evidence for a definite linkage of the biosynthesis processes with structures of the cell nucleus.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure*; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D008854:Microscopy, Electron; D009536:Niacinamide / Q000172:deficiency*; D009539:Nicotinic Acids / Q000008:administration & dosage*; D051381:Rats; D014804:Vitamin B Deficiency / Q000473:pathology
chemical_list: D009539:Nicotinic Acids; D009536:Niacinamide
vernacular_title: Zmini strukturi iuder klitin prchinki pp-avitaminoznikh shchuriv pri vvedenni nikotinovoi kisloti