Familial balanced (7;11;21) translocation and Down's syndrome in two siblings.
Cytogenetic studies of a family with two children with Down's syndrome have revealed a balanced reciprocal translocation between chromosomes No. 7, 11 and 21 in the mother. One of three daughters has inherited this translocation. two mongoloid daughters have a supernumerary chromosome No. 21 in addition to the translocation.
D000293:Adolescent; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D014178:Translocation, Genetic