Therapeutic studies with BCG, cyclophosphamide and surgery alone and in combination on the autochthonous mammary carcinoma of the rat.
In a randomized study the effects of BCG, cyclophosphamide and surgery alone and in combination on the mammary carcinoma (induced by 7,12-dimethylbenz(a)anthracene) of the rat were investigated. Surgical excision of the tumours increased the survival time. Cyclophosphamide retarded growth of tumours and delayed the appearance of relapses compared to surgery. A single, intravenous injection of BCG (10(7) viable organisms) showed no statistically significant retardation of tumours. Immunotherapy with BCG could not increase the effectiveness of cyclophosphamide or surgery or their combination.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D001551:Benz(a)Anthracenes; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D007167:Immunotherapy / Q000379:methods; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D051381:Rats
D001500:BCG Vaccine; D001551:Benz(a)Anthracenes; D003520:Cyclophosphamide