Levodopa in Huntingtons chorea.
Sixteen patients with Huntington's chorea were treated for periods as long as 8 months with levodopa. The condition of none of the patients improved; in fact, there appeared to be an exacerbation of chorea and dementia in addition to undesirable behavioural changes. Therefore, future use of levodopa in these patients is not warranted. The postulated association of low homovanillic acid values in cerebrospinal fluid and favourable response to levodopa therapy was not borne out.
D000328:Adult; D000368:Aged; D001519:Behavior / Q000187:drug effects; D004334:Drug Administration Schedule; D004569:Electroencephalography; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011339:Probenecid
D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D011339:Probenecid; D006719:Homovanillic Acid