Strand breakage in rat brain DNA and its repair induced by ethylnitrosourea in vivo.
The damage and repair of rat brain DNA was studied in vivo after a single carcinogenic dose of ethylnitrosourea. Fragmentation of the brain DNA produced by this carcinogen was demonstrated on alkaline sucrose gradients. By the 24th hrs after treatment with ethylnitrosourea the single-strand damage to DNA was not completely repaired. As the highly differentiated cells of the central nervous system do not proliferate, it is possible that during brain carcinogenesis delayed repair of DNA of primitive cells might be needed for the formation of tumor anlage.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001932:Brain Neoplasms / Q000139:chemically induced / Q000196:embryology; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects*; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D009690:Nucleic Acid Conformation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats
D009607:Nitrosourea Compounds; D004247:DNA; D005038:Ethylnitrosourea