title: Occupational contact dermatitis due to croton (Codiaeum variegatum (L.) A. Juss var. pictum (Lodd.) Muell. Arg.). Sensitization by plants of the Euphorbiaceae.
abstract: One of today's most decorative and popular ornamental potted plants is Croton. Handling this plant over a period of 6 months produced contact eczema of the hands in a nursery gardener. Patch tests with Croton leaves were positive. Control tests remained negative. Sensitization experiments in guinea pigs with a methanolic extract of the leaves were successful. All results of the study indicate that: -latex of croton produces no primary irritant reaction -latex is able to induce a real contact allergy -contact allergens are constituents of the milky sap. Whether the di- and triesters of phorbol so far isolated as irritant and cocarcinogenic factors from the latex of various Euphorbiaceae species and sensitizers shall be investigated in further experiments.
mesh_terms: D000485:Allergens; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004485:Eczema / Q000209:etiology*; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000633:toxicity; D010947:Plants, Toxic; D012882:Skin Tests
chemical_list: D000485:Allergens; D010936:Plant Extracts