Initial events in radiation-induced atheromatosis I. Activation of lysosomal enzymes.
Local irradiation of the carotid artery of the hypercholesterolemic rabbit with 2000 rd of X-rays gives rise to infiltration of lipid droplets in the intima and media, becoming visible 3 days after the irradiation. At the same time, acid phosphatase and beta-glucuronidase become activated. These enhanced activities are localized in different cells of the arterial wall. Acid phosphatase activity is localized in the intima, while the beta-glucuronidase activation is found preferentially in the media. A functional heterogeneity of the lysosomal content of the different cells is suggested. A model for the development of the radiation-induced atheromatosis is presented.
D000135:Acid Phosphatase; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D002339:Carotid Arteries / Q000201:enzymology / Q000528:radiation effects*; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000528:radiation effects; D005260:Female; D005966:Glucuronidase; D006025:Glycosaminoglycans / Q000528:radiation effects; D006651:Histocytochemistry; D006937:Hypercholesterolemia / Q000201:enzymology; D050356:Lipid Metabolism; D008247:Lysosomes / Q000201:enzymology* / Q000528:radiation effects; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000150:complications*; D011878:Radiotherapy / Q000009:adverse effects
D006025:Glycosaminoglycans; D000135:Acid Phosphatase; D005966:Glucuronidase