[Influence of vitamin A on the distribution of glycosaminoglycans in rat tissues].
Glycosaminoglycans (GAG) from brains, intestines, livers and skin of rats were analyzed by electrophoretic and enzymatic methods. Variations in GAG distribution have been studied in rats fed on a vitamin-A-deficient diet and on a diet supplemented with an excessive quantity of vitamin A. Hypervitaminosis A resulted in a decrease in GAG isolated from connective and hepatic tissues. The incorporation of labeled sulfate into the GAG of these tissues has been studied. Hypervitaminosis A resulted in a decrease in sulfate incorporation into the GAG isolated from connective tissues. A large increase in sulfate incorporation into the GAC of the digestive tract is observed for vitamin-A-treated rats. A decrease is noted for vitamin-A-deficient rats. It was suggested that these variations in distribution and specific activity of GAG could be due to different effects of vitamin A. Vitamin A seems to be required either for the release of lysosomal enzymes or for the sulfatation and elongation of certain glucidic chains in the biosynthesis of sulfated GAG.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004032:Diet; D006025:Glycosaminoglycans / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D012867:Skin / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism; D014801:Vitamin A / Q000494:pharmacology*
D006025:Glycosaminoglycans; D013431:Sulfates; D014801:Vitamin A
Influence de la vitamine A sur la distribution des glycosaminoglycanes dans les tissus du rat