Coagulation defects in rabbits after infusion of dispersed fluorochemicals.
Coagulation parameters were studied in rabbits during and after intravenous infusion of suspensions of dispersed fluorochemicals. Blood samples from rabbits given dispersed perfluorobutyltetrahydrofurane or perfluorotributylamine showed thrombocytopenia, prolongation of activated partial thromboplastin time, and decreases in Factors X and XI. The possible presence of an inhibitor of coagulation was suggested by the prolongation of prothrombin time when measured with serial dilutions of thromboplastin reagent. These abnormalities were not found in whole blood or platelet-rich plasma after incubation in vitro with dispersed fluorochemical.
D000818:Animals; D000925:Anticoagulants / Q000097:blood; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D001792:Blood Platelets / Q000166:cytology; D001794:Blood Pressure; D002082:Butylamines / Q000009:adverse effects*; D002452:Cell Count; D005164:Factor IX / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005172:Factor XI / Q000032:analysis; D005174:Factor XII / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005466:Fluorocarbons / Q000009:adverse effects*; D005663:Furans / Q000009:adverse effects*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000009:adverse effects*; D011817:Rabbits; D012710:Serum Albumin, Bovine
D000925:Anticoagulants; D002082:Butylamines; D005338:Fibrin Fibrinogen Degradation Products; D005466:Fluorocarbons; D005663:Furans; D006845:Hydrocarbons, Fluorinated; D012710:Serum Albumin, Bovine; D005165:Factor V; D005169:Factor VIII; D005164:Factor IX; D005170:Factor X; D005174:Factor XII; D005172:Factor XI