Effect of aldosterone and methylprednisolone on cardiac NaK-ATPase.
Aldosterone (15 microgram BID) and methylprednisolone (8 mg QD) administration to female guinea-pigs augmented both the total and the specific activity of NaK-ATPase but not the activity of adenylate cyclase in the cardiac sarcolemma. The rise in NaK-ATPase was due to increase in the number of enzyme molecules; catalytic activity and ouabain-sensitivity of individual molecules did not change.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008775:Methylprednisolone / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology*; D010042:Ouabain / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D000450:Aldosterone; D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium; D008775:Methylprednisolone