Proliferation of Rous sarcoma virus-infected, but not of normal, chicken fibroblasts in oxygen-enriched environment: preliminary report.
Both normal and Rous sarcoma virus-infected chicken fibroblasts proliferate in an incubator containing 95% air, 5% CO2. In an incubator atmosphere enriched with oxygen, however, the normal fibroblasts are maintained without proliferation, while the Rous sarcoma virus-infected fibroblasts continue to proliferate. This suggests that a respiratory function may be involved in the regulation of proliferation of normal cells, and that neoplastic cells may proliferate autonomously because of a deficiency in this regulatory function.
D001272:Atmosphere; D001358:Avian Sarcoma Viruses; D002118:Calcium / Q000378:metabolism; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005347:Fibroblasts; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption
D002118:Calcium