[Carbohydrate metabolism in the liver in acute ischemia].
The article deals with oxidation of different substrates, intensity of glycolytic and glycogenolytic processes in mitochondria and homogenates of dog liver with its 2-hour exclusion from circulation under conditions of endotracheal ether-oxygen narcosis. It was established that already 30-60-minute ischemia causes a decrease in intensity of succinate, alpha-ketoglutarate oxidation and acceptor respiration, inhibiton in the activity of the citrate cycle enzymes; succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, isocytrate dehydrogenase. The activity of NAD-dependent malate dehydrogenasedehydrogenase and Mg2+-ATPase as well as intensity of NADN oxidation in mitochondria increase. After 2-hour ischemia the activity of Mg2+-ATPase, cytochrome oxidase and peroxidase lowers. A sharply developed glycogenolysis is accompanied by inhibition of phosphorylase activity and a two-fold stimulation of the glycolytic reactions. Peculiarities in regulation of enzymatic reactions under conditions of ischemia and their role in origin of metabolism disturbances in the liver are under discussion.
D000208:Acute Disease; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D004285:Dogs; D003576:Electron Transport Complex IV / Q000378:metabolism; D006019:Glycolysis; D007511:Ischemia / Q000378:metabolism*; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism
D008112:Liver Glycogen; D008291:Malate Dehydrogenase; D010544:Peroxidases; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases
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