title: Immunological release of histamine from human lung. II. Studies on acetylcholine and the anticholinergic agent ipratropium bromide.
abstract: The experiments reported in this work have been performed to measure the effects of acetylcholine and the anticholinergic agent ipratropium bromide on the antigen-induced release of histamine from sensitized human lung in vitro. Primarily, ipratropium bromide did not have any effect, even at higher concentrations. Acetylcholine at a concentration of 1 x 10(-7)M increased the antigen-induced release of histamine by approximately 41%. When the lung tissue was treated with ipratropium bromide before acetylcholine, the competitive inhibition of the cholinergic receptor almost completely abolished this acetylcholine-induced increase of histamine release. Therefore, in our opinion, anticholinergic agents are primarily useful in vagus-controlled chronic obstructive ventilatory disorders; they are of secondary importance in allergic bronchial asthma.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D001249:Asthma / Q000276:immunology; D001286:Atropine Derivatives / Q000494:pharmacology*; D006633:Histamine Antagonists; D006636:Histamine Release; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology*; D008168:Lung / Q000276:immunology* / Q000378:metabolism
chemical_list: D001286:Atropine Derivatives; D006633:Histamine Antagonists; D009241:Ipratropium; D000109:Acetylcholine