[Morphological manifestations of the intracellular toxic effect of microorganisms of the ornithosis-lymphogranuloma-trachoma group].
Interactions of the causative agents of meningopneumonia and ovine abortion with pulmonary macrophages in experimental infection in white mice were studied by histological, immunofluorescent and electron microscopic methods. The causative agent of meningopneumonia did not multiply in colonies and caused toxic lesions in the cells and formed cytoplasmic oxiphilic inclusion bodies. Being the product of cell degeneration, these oxiphilic inclusion bodies were conducive to long-term survival of the cell and slow release from them of elementary bodies of meningopneumonia agent. The agent of ovine abortion multiplied in colonies without toxic affection of the cells or formation of oxiphilic inclusion bodies. It is suggested that oxiphilic inclusion bodies represent morphological manifestation of the intracellular toxic effect of rickettsial and ornithosis-like agents possessing dissociated (non-colonial) mode of multiplication.
D000034:Abortion, Veterinary / Q000382:microbiology; D000818:Animals; D002690:Chlamydia Infections / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D002479:Inclusion Bodies; D008264:Macrophages; D008297:Male; D008581:Meningitis / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D011022:Pneumonia, Rickettsial / Q000473:pathology*; D011247:Pregnancy; D011650:Pulmonary Alveoli / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology / Q000473:pathology
Morfologicheskie proiavleniia vnutrikletochnogo toksicheskogo deĭstviia u vozbuditeleĭ iz gruppy ornitoza-limfogranulemy-trakhomy