title: Human adenohypophysis in Nelson syndrome. Ultrastructural and clinical study.
abstract: The manifestations that comprise the disease known as Nelson syndrome are pituitary hyperplasia and cutaneous hyperpigmentation, which sometimes follow bilateral adrenalectomy, in patients with hypercortisolism. We present a comprehensive endocrinologic, structural study of a patient in whom the evidence obtained supports the hypotheses that: (a) the primary disorder in this form of hypercortisolism is probably hypothalamic; (b) the hyperplasia of the adenohypophysis, following adrenalectomy, is closely associated with lowered plasma cortisol levels; and (c) the cillular hyperplasia in the adenohypophysis involves primarily the corticotroph, a cell believed to be associated with the secretion of adrenocorticotrophic hormone and melanocyte-stimulating hormone.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000315:Adrenalectomy; D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010859:Pigmentation Disorders / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010900:Pituitary Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010902:Pituitary Gland / Q000648:ultrastructure*; D010903:Pituitary Gland, Anterior / Q000648:ultrastructure*; D013577:Syndrome
chemical_list: D015068:17-Ketosteroids; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones