[Immunologic status in Hodgkin patients: correlation with Epstein-Barr virus titers].
1. In Hodgkin's disease patient's immunological in vitro and in vivo parameters are of prognostic importance. 2. Skin test reactivity correlates to peripheral T-lymphocyte counts and Con A induced lymphoblastogenesis. 3. Con A is the most sensitive in vitro indicator for detecting latent immunodeficiency. 4. Hodgkin patients in long term remission after tumor reductive therapy exhibit a qualitative and quantitative lymphocyte defect. 5. In Hodgkin patients Herpes virus related antibody titers are elevated against Epstein Barr virus (EBV). The elevation coincides with a decreased T-cell number and function. Antibodies against other Herpes viruses (HSV, CMV, VZV) are in the normal range, when tested by the complement fixation method.
D000914:Antibodies, Viral / Q000032:analysis; D003208:Concanavalin A / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D011379:Prognosis; D012075:Remission, Spontaneous; D012882:Skin Tests; D013601:T-Lymphocytes
D000914:Antibodies, Viral; D003208:Concanavalin A
Immunologischer Status bei Hodgkin-Patienten: Korrelation zu Epstein-Barr-Virus(EBV)-Titern