[Effect of an MAO inhibitor, phenelzine, on acetylation of isoniazid by isolated perfused rat liver].
Phenelzin, a monoamine oxydase inhibitor, administered in vivo, in rats, slowed down the initial velocity of isoniazid acetylation in isolated perfused liver. After in vitro addition in perfusion medium phenelzin decreased as well the initial velocity of acetylation as the total amount of acetylated substrate.
D000107:Acetylation; D000818:Animals; D066298:In Vitro Techniques; D007538:Isoniazid / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D010624:Phenelzine / Q000494:pharmacology*; D051381:Rats
D010624:Phenelzine; D007538:Isoniazid
Influence d'un IMAO, la phénelzine, sur l'acétylation de l'isoniazide par le foie isolé perfusé de rat.