title: Genetics of kidney allograft survival in dogs. I. Relevance of subregions of the major histocompatibility complex in recipients without immunosuppressive therapy.
abstract: The influence of subregions of the canine major histocompatibility complex (MHC) on renal allograft survival is assessed in recipients without immunosuppressive therapy. Results in six beagle littermate donor-recipient pairs in which the donor or recipient had a recombination in the MHC are compatible with the concept of a predominant role for the subregion containing the major mixed lymphocyte reaction (MLR) locus in determining allograft survival. Results in unrelated mongrel dogs indicate that compatibility for MLR induces a longer kidney allograft survival than compatibility for the serologically defined (SD) antigens. However, the effect of combined matching for MLR and SD antigens in unrelated donor-recipient pairs is slight in comparison to the effect of MLR and/or SD matching in littermate-related dogs. This indicates that other important histocompatibility systems probably exist in this species.
mesh_terms: D000818:Animals; D004285:Dogs / Q000235:genetics*; D006085:Graft Survival; D006650:Histocompatibility Testing; D007167:Immunotherapy; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D011995:Recombination, Genetic; D014184:Transplantation, Homologous