Simultaneous selection of mutants in gluconeogenesis and nucleoside catabolism in Salmonella typhimurium.
Penicillin selection in minimal thymidine medium, used to select mutants in deoxynucleoside catabolism, also yields a high percentage (37%) of mutants in fructose diphosphatase. The expression of the deo regulon is retarded in the mutants defective in the glyconeogenic pathway.
D003470:Culture Media; D003853:Deoxyribonucleosides / Q000378:metabolism*; D003855:Deoxyribose / Q000378:metabolism; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005943:Gluconeogenesis; D005947:Glucose / Q000378:metabolism; D009154:Mutation; D010406:Penicillins / Q000494:pharmacology; D010770:Phosphotransferases / Q000378:metabolism; D012486:Salmonella typhimurium / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
D003470:Culture Media; D003853:Deoxyribonucleosides; D010406:Penicillins; D003855:Deoxyribose; D010770:Phosphotransferases; D006597:Fructose-Bisphosphatase; D005947:Glucose; D013936:Thymidine