Elevated urinary testosterone and androstanediol in precocious adrenarche.
Using a newly devised radioligand method for the simultaneous determination of urinary testosterone (T) and androstanediol (Adiol) nine girls with precocious adrenarche were evaluated. In the base-line state average urinary T excretion (1.29 mug/24 hr) and Adiol excretion (1.33 mug/24 hr) were significantly elevated when compared with 15 age-matched controls (0.3 and 0.33 mug/ 24 hr, respectively, P less than 0.001 for both). Adrenocorticotropic hormone (ACTH) infusion performed in five patients with precocious adrenarche produced at least a 50 greater than increase in urinary T excretion in all and a similar increase in Adiol excretion in four of five patients. Dexamethasone administration in the same five patients produced a 25 greater than fall in urinary T excretion in all and a comparable fall in Adiol in four.
D015068:17-Ketosteroids / Q000652:urine; D000302:Adrenal Cortex / Q000502:physiology*; D000311:Adrenal Glands / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D015113:Androstane-3,17-diol / Q000652:urine*; D000731:Androstanes / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002854:Chromatography, Paper; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006801:Humans; D008722:Methods; D011629:Puberty, Precocious / Q000652:urine; D011869:Radioligand Assay; D013739:Testosterone / Q000652:urine*
D015068:17-Ketosteroids; D000731:Androstanes; D015113:Androstane-3,17-diol; D013739:Testosterone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone