title: Chromosome abnormalities in neurological diseases.
abstract: The current status of research into chromosomal abnormalities in neurological diseases is reviewed. The only possible association between chromosome aberration and neurological disorder is found in ataxia telangiectasia and in tumours of the nervous system. In the remaining diseases reviewed, no specific association was confirmed. This was expected to some extent, since the majority of these diseases (spinal muscular atrophies, muscular dystrophies, etc.) are due to single gene defects.
mesh_terms: D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D000013:Congenital Abnormalities / Q000235:genetics; D003704:Dementia / Q000235:genetics; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000235:genetics; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics; D009133:Muscular Atrophy / Q000235:genetics; D009136:Muscular Dystrophies / Q000235:genetics; D009224:Myotonia Congenita / Q000235:genetics; D009223:Myotonic Dystrophy / Q000235:genetics; D009380:Neoplasms, Nerve Tissue / Q000235:genetics; D009422:Nervous System Diseases / Q000235:genetics*; D013064:Speech Disorders / Q000235:genetics; D013122:Spinal Diseases / Q000235:genetics; D013341:Sturge-Weber Syndrome / Q000235:genetics; D014202:Tremor / Q000235:genetics