Immunological differential diagnosis of human brain tumours.
Results of immunological experiments with various human brain tumours show differences between astrocytoma and glioblastoma multiforme when brain-specific alpha2-glycoprotein is used as an immunological marker. On this basis a tentative model of cytogenesis and oncogenic transformation of glial cells was presented. Morphological resemblances between the brain-specific alpha2-glycoprotein immuno-precipitation lines obtained from astrocytoma cells and from normal cerebral white matter treated with neuraminidase are discussed in relation to experimental and clinical studies of tumour cells treated with neuraminidase.
D000951:Antigens, Neoplasm; D001254:Astrocytoma / Q000175:diagnosis* / Q000276:immunology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000175:diagnosis* / Q000276:immunology; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis
D000951:Antigens, Neoplasm; D006023:Glycoproteins