title: Arsine toxicity aboard the Asiafreighter.
abstract: Eight sailors on board the Asiafreighter were exposed to arsine that had escaped from a cylinder in the cargo hold. Four suffered severe toxicity and within a few hours had developed fever, weakness, nausea, vomiting, diarrhoea, abdominal pain, and haemoglobinuria. These patients had pronounced intravascular haemolysis, which in one patient was complete. This patient was also stuporose and anoxic, a condition attributed to failure of oxygen transport and sludging of red cell debris in the cerebral and pulmonary circulations, but he regained a normal level of consciousness after exchange transfusion. Evidence of marrow depression was present: the reticulocyte response to the haemolysis was poor and there was a thrombocytopenia. All four patients developed renal failure, one being totally anuric for five weeks. Two patients developed peripheral neuropathy, and one was still severely disabled six months after the incident. The other four patients had a similar, though less severe, illness.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D020261:Arsenic Poisoning; D001152:Arsenicals; D001856:Bone Marrow Examination; D056486:Chemical and Drug Induced Liver Injury; D003404:Creatinine / Q000097:blood; D003907:Dexamethasone / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced; D004781:Environmental Exposure; D005078:Exchange Transfusion, Whole Blood; D005334:Fever / Q000139:chemically induced; D005739:Gas Poisoning / Q000097:blood / Q000150:complications; D006197:Hair / Q000032:analysis; D006456:Hemoglobinuria / Q000139:chemically induced; D006461:Hemolysis; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009326:Naval Medicine; D010292:Paresthesia / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors; D014508:Urea / Q000097:blood; D014839:Vomiting / Q000139:chemically induced
chemical_list: D001152:Arsenicals; D003907:Dexamethasone; D014508:Urea; D003404:Creatinine; C006633:arsine