Progesterone concentration in placenta, molar tissue, and ovarian theca lutein cyst.
Progesterone concentrations in 2 full-term normal placentas, molar tissue from 3 cases of hydatidiform mole were measured by competitive protein binding. Sephadex LH-20 column chromatographic separation of extracts from these tissues showed that, in placental and molar tissue, 85 to 95% of the extracts were progesterone and very small amounts of 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone. The concentration of progesterone in the placenta were 368.8 and 317.2 ng/g tissue, respectively, while in molar tissue the concentration were 2474.5, 1974.6, and 4146.0 ng/g tissue, respectively. Progesterone concentration in ovarian tissue was between 1121;2 and 1440.9 ng/g tissue. It is suggested that the high concentration of progesterone in molar tissue reflects functional capacity of the abnormal trophoblast in progesterone synthesis and accumulation of progesterone due to absence of a fetus. The lower concentration of progesterone in the ovary in molar pregnancy would appear to suggest that the ovary is a secondary source of progesterone in molar pregnancy.
D006063:Chorionic Gonadotropin / Q000378:metabolism; D002845:Chromatography; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000032:analysis*; D006908:Hydroxyprogesterones / Q000032:analysis; D007044:Hysterectomy; D066298:In Vitro Techniques; D010051:Ovarian Neoplasms / Q000032:analysis*; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000032:analysis*; D013798:Thecoma / Q000032:analysis*
D006063:Chorionic Gonadotropin; D006908:Hydroxyprogesterones; D011374:Progesterone