title: Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.
abstract: 5-Amino-2,5-dideoxy-5-iodouridine, a nel thymidine analogue, is a potent inhibitor of herpes simplex virus type 1 replication. In contrast to most other nucleoside analogues which possess antiviral activity, 5-amino-2,5-dideoxy-5-iodouridine exhibits little, if any, cellular toxicity. Preliminary evidence suggests that 5-amino-2,5-dideoxy-5-iodouridine selectively inhibits viral-specific DNA synthesis.
mesh_terms: D000588:Amines / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000494:pharmacology*; D004279:DNA, Viral / Q000096:biosynthesis; D007065:Idoxuridine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D018139:Simplexvirus / Q000032:analysis / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication
chemical_list: D000588:Amines; D000998:Antiviral Agents; D004279:DNA, Viral; D007065:Idoxuridine