Reticuloendothelial system function test using 131I-labeled aggregated albumin.
The reticuloendothelial system function test using 131I-labeled aggregated human albumin (131IAA) as test particle is thought to be one of the best methods for the study of RES function of human beings. This method needs a large amount of 131IAA, but 131IAA has been used as a tracer of liver scintiscanning, and we tired to study RES function by using commercially available 131IAA specially made as tracer of liver scintiscanning. Because the amount of 131IAA used in this study was smaller than the critical dosis, our interest was focussed on the catabolic activity of 131IAA phagocytized by Kupffer's cells. The plasma obtained 60 min after 131IAA injection was fractionated into two distinct peaks by gel column chromatography; ionic 131I and protein-bound 131IAA. The ratio between ionic 131I and bound 131IAA (F/B ratio) was studied in various diseases. The F/B ratios of liver cirrhosis and hepatoma were significantly lower than that of the control. The lowered F/B ratio had no correlation with other liver function tests, data of hepatic scintiscanning, or with clinical findings. The F/B ratio was also not correlated with congo red index as RES function test.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000503:physiopathology; D002769:Cholelithiasis / Q000503:physiopathology; D002779:Cholestasis / Q000378:metabolism; D005260:Female; D006505:Hepatitis / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000503:physiopathology; D008297:Male; D008722:Methods; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000502:physiology* / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology; D010587:Phagocytosis; D012711:Serum Albumin, Radio-Iodinated
D012711:Serum Albumin, Radio-Iodinated