[Experimental study of the effectiveness of antibacterial preparations in treating dysentery].
It was found that for successful elaboration of effective schemes for the use of antibacterial drugs in treatment of dysentery it was necessary to exploit various experimental models providing consideration of the drug toxicity and effect on the extra- and intracellular growth of the bacteria in addition to the other factors. The administration of enteroceptol for 3 days followed by furazolidon showed the best therapeutic effect in the treatment of guinea pigs with Shigella keratoconjunctivitis and Syrian hamsters with dysentery. The above drugs had low toxicity which was shown in the experiments with Hep-2 cell cultures. It was concluded that the use of the drugs with different modes of action was advisable in treatment of dysentery.
D000818:Animals; D002478:Cells, Cultured; D007464:Clioquinol / Q000627:therapeutic use*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D015643:Erythromycin Ethylsuccinate / Q000627:therapeutic use*; D005664:Furazolidone / Q000627:therapeutic use*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007637:Keratoconjunctivitis / Q000188:drug therapy; D008647:Mesocricetus; D012764:Shigella sonnei / Q000187:drug effects; D013997:Time Factors
D015643:Erythromycin Ethylsuccinate; D005664:Furazolidone; D007464:Clioquinol
Eksperimental'noe izuchenie éffektivnosti nekotorykh antibakterial'nykh preparatov pri lechenii dizenterii.