[Binding of H3-aldosterone to cytoplasmic receptors of the kidney in various functional states of the organ target].
A study was made of the capacity of the cytoplasmic cell fraction of rat kidney to bind H3-aldosterone, depending on the level of Na uptake with food, and, consequently, on the intensity of aldosterone secretion by the adrenal glands. It was shown by Sketchard's method that there existed in the cytoplasmic fraction of the kidney cells of rats with a high and low level of aldosterone secretion two classes of receptors binding aldosterone with a different degree of affinity. The number of binding sites for aldosterone in the 1st class of receptors, more specific for mineralocorticoids in the animals with a low level of aldosterone secretion (Na loading), was double that in comparison with the animals with a high level of aldosterone (Na deficiency). It is supposed that an increased aldosterone concentration in the organism in Na deficiency increased the transport of the specific hormone-receptor complex from the cytoplasm into the nucleus.
D000302:Adrenal Cortex / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats; D011956:Receptors, Cell Surface; D012964:Sodium
D011956:Receptors, Cell Surface; D000450:Aldosterone; D012964:Sodium
Sviazyvanie H3-al'dosterona s tsitoplaszmaticheskimi retseptorami pochki pri razlichnykh funktsional'nykh sostoianiiakh organa-misheni