The experience with clinical application of hydron pouches in tumor chemotherapy.
Hydron pouches were applied in three cases of embryonal hepatomas in infants. Cyclophosphamide (one case) and methotrexate (two cases) were used for filling of pouches in order to accomplish local chemotherapeutical effect directly on the tumor. Histopathological examination showed good compatibility of pouches to the liver tissue. No therapeutical effect was observed in a set of experiments due to a small size of pouches as compared to big masses of tumor. Some suggestions for further development of this method are presented.
D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D004343:Drug Implants; D005260:Female; D005782:Gels / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008689:Methacrylates / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use
D004343:Drug Implants; D005782:Gels; D008689:Methacrylates; D003520:Cyclophosphamide; D008727:Methotrexate