Pharmacologic modification of induced asthma.
Oral adrenergic substances (e.g., ephedrine) and phosphodiesterase inhibitors (e.g., theophylline) can have a prophylactic effect on natural or experimentally induced asthma by maintaining high levels of cyclic AMP in the target organ cells. This controlled, double-blind study evaluates these drugs alone and in a standard dosage combination in blocking asthma induced by the inhalation of pollen allergens among highly selected patients. The results support the claim that oral adrenergic drugs and xanthines can be useful in the prophylaxis of asthma.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D000242:Cyclic AMP / Q000378:metabolism; D004357:Drug Synergism; D004809:Ephedrine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D006969:Hypersensitivity, Immediate / Q000517:prevention & control; D008297:Male; D010919:Placebos; D011058:Pollen; D012123:Pulmonary Ventilation / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D010919:Placebos; D013806:Theophylline; D000242:Cyclic AMP; D004809:Ephedrine