Effects of serotonin, carbamylcholine, and ascorbic acid on leukocyte cyclic GMP and chemotaxis.
Serotonin, ascorbic acid, and carbamylcholine enhanced the chemotactic responsiveness of human monocytes to endotoxin-treated serum. These agents caused significant accumulation of cyclic GMP in monocytes. PMN leukocyte chemotaxis was also enhanced by these agents although significant increases in cyclic GMP were not demonstrated.
D001205:Ascorbic Acid / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects*; D006152:Cyclic GMP / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D006632:Histamine; D002217:Carbachol; D006152:Cyclic GMP; D001205:Ascorbic Acid; D001920:Bradykinin