[Effect of morphine in vitro on the oxidative phosphorylation in rat liver mitochondria].
The rates of respiration in the presence of ADP and of phosphorylation as an ATP-ase activity of rat liver mitochondria was inhibited was in vitro by morphine with Ki=6.5 mM. The uncoupler-stimulated respiration of the mitochondria and the activity of ATP-ase and synthesis of ATP in the submitochondrial particles were not altered in the presence of morphine. It is suggested that morphine inhibited the adenine nucleotide transport through the mitochondrial membrane
D000244:Adenosine Diphosphate; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D004794:Enzyme Repression / Q000187:drug effects; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000187:drug effects; D009020:Morphine / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000378:metabolism; D009206:Myocardium / Q000648:ultrastructure; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010770:Phosphotransferases / Q000378:metabolism; D051381:Rats
D009097:Multienzyme Complexes; D000244:Adenosine Diphosphate; D009020:Morphine; D010770:Phosphotransferases; D000251:Adenosine Triphosphatases
Vliianie morfina in vitro na okislitel'noe fosforilirovanie v mitokhondriiakh pecheni krysy