[Resistance to association of antibiotics (polymyxin and penicillin) in relation to cell concentration of two bacterial species in the same inoculum. Complementary inoculum effect].
Dense suspensions of Sa. typhi (Polys Penr) and of St. aureus (Polyr Pens) proliferate on gelose medium added with the two antibiotics only if the inoculum is mixed. The growth is probably due to the partial neutralization of the antibiotics following the formation of complexes between these antibiotics and some constituents of the two strains.
D004338:Drug Combinations; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D011113:Polymyxins / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
D004338:Drug Combinations; D011113:Polymyxins; D010400:Penicillin G
Résistance aux associations d'antibiotiques (polymyxine et péniciline) liée à la concentration des cellules de deux espéces bactériennes dans le même inoculum. Action conjuguée des effets inoculum