title: Pleiotropic effects of ribosomal mutations for cycloheximide resistance in a double-resistant homocaryon of Neurospora crassa.
abstract: Pleiotropic effects of two ribosomal mutations for cycloheximide resistance were studied in a double-resistant homocaryon. The results obtained indicated that the combination of the two ribosomal mutations results in: (i) morphological abnormalities which suggest a severe distortion in the extension of cell walls and membranes; (ii) disturbance in the normal 60S-40S subunit ratio; (iii) decreased rate of cell mass production not necessarily associated with inbalance in the 60S-40S ratio; and (iv) cold sensitivity which does not interfere with mycelial mass production.
mesh_terms: D003080:Cold Temperature; D003513:Cycloheximide / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005796:Genes; D009154:Mutation; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000166:cytology / Q000187:drug effects / Q000235:genetics*; D012270:Ribosomes / Q000032:analysis
chemical_list: D003513:Cycloheximide