Immunisation trials with live attenuated cytomegalovirus TOWNE 125.
Trials with live cytomegalovirus (TOWNE 125 strain), which was attenuated by 125 passages exclusively on WI-38 cells, were done in adult volunteers. No virus take occured after oral/nasal application. When 10(3) TCD50 was given intramuscularly an IgG antibody response was detected at four weeks in all of ten volunteers tested by immunofluorescence; an IgM response was found in seven. Only mild local side-effects and relative lymphocytosis were observed. No virus excretion was found. Many questions remain to be answered by further trials before a cytomegalovirus vaccine can be given to adolescent girls.
D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D009500:Neutralization Tests; D011247:Pregnancy; D012409:Rubella / Q000276:immunology; D014613:Vaccines, Attenuated
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007136:Immunoglobulins; D014613:Vaccines, Attenuated