Effect of steroid hormones on growth of adrenocortical carcinoma transplants in mice;.
The growth of transplanted carcinomas originating in a gonadectomized C3H male mouse was much faster in intact male mice than in intact or gonadectomized females. Administration of 17beta-estradiol or testosterone propionate in pellets resulted in a marked acceleration of the carcinoma growth in intact female mice. Progesterone and deoxycorticosterone acetate exerted no influence on the carcinoma growth. Neither gonadotropins (pregnant mare's serum gonadotropin plus human chorionic gonadotropin) nor ACTH accelerated the growth. In contrast, cortisone acetate in pellets markedly reduced the growth rate of carcinoma transplants when administered simultaneously with the transplantation. Cortisone acetate also arrested the growth-accelerating effect of 17beta-estradiol on transplanted carcinomas.
D000306:Adrenal Cortex Neoplasms / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002369:Castration; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003348:Cortisone / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D011374:Progesterone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology; D014184:Transplantation, Homologous
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D006728:Hormones; D013739:Testosterone; D003900:Desoxycorticosterone; D011374:Progesterone; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D003348:Cortisone