Correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to Concanavallin A.
Spleen cells from nonlethally MCMV-infected weanling and adult DBA/2 mice had diminished responses to Con A stimulation. In contrast, only lethal MCMV infections were associated with a complete suppression of the Con A response. The immune response to SRBC was depressed even in asymptomatic infections of weanling and adult mice. A marked maturation of resistance to the lethal effects of MCMV infection was found to occur during the fourth week of life.
D000367:Age Factors; D000818:Animals; D000941:Antigens; D003208:Concanavalin A / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000276:immunology / Q000472:pathogenicity*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D008811:Mice, Inbred DBA; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D010948:Viral Plaque Assay; D014777:Virus Diseases
D000941:Antigens; D003208:Concanavalin A