Translation in vitro of vesicular stomatitis virus mRNA lacking 5'-terminal 7-methylguanosine.
The 5'-terminus 7-methylguanosine of vesicular stomatitis virus mRNA is not essential for translation of the mRNA. The 7-methylguanosine seems to have a mediating rather than an obligatory role in ribosome binding by the mRNA and in mRNA translation.
D002474:Cell-Free System; D006150:Guanine Nucleotides / Q000378:metabolism; D007700:Kinetics; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000378:metabolism*
D006150:Guanine Nucleotides; D012333:RNA, Messenger; D012367:RNA, Viral