Hyperkeratosis palmoplantaris with periodontosis (Papillon-Lefevre syndrome): report of three cases, two occurring in siblings.
Three cases of palmar-plantar hyperkeratosis with periodontosis, two cases of which occurred in siblings, are reported. The parents were unaffected, and parental consanguinity was present in all three cases. All essential features of the syndrome were present in these cases.
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D010214:Papillon-Lefevre Disease / Q000097:blood / Q000235:genetics / Q000473:pathology*; D010510:Periodontal Diseases; D012867:Skin / Q000473:pathology