Parathyroid adenomas following irradiation.
Parathyroid adenomas have been demonstrated to occur following external head and neck irradiation. The median latency interval is 30 years. In a series of 74 consecutive patients with histologically diagnosed parathyroid adenomas, 25% gave a history of prior radiation exposure. When compared to a matched control incidence of 7.9%, statistical significance is reached at p less than 0.01. Thyroid abnormalities were present in 68% of the irradiated patients, and 30% of these were malignant. Tumor of skin, breast, and parotid gland also occurrred more frequently than expected. Forty-seven percent of the irradiated group had malignant neoplasms within the radiation field. The histopathology of the radiation-associated parathyroid adenomas is similar to that seen experimentally.
D000152:Acne Vulgaris / Q000532:radiotherapy; D000236:Adenoma / Q000209:etiology* / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D005260:Female; D005471:Fluoroscopy / Q000009:adverse effects; D006042:Goiter / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000648:ultrastructure; D010282:Parathyroid Neoplasms / Q000209:etiology* / Q000648:ultrastructure; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors