title: Changes in the contractile material of human skeletal muscle following tendinous injury.
abstract: The most marked changes in the human muscle following tendinous injury can be observed in the contractile components. There is a widening of the Z-membrane, dispersion of the sarcomers, a break in their continuity, and detached bundles of myofibrils are found in the sarcoplasm. A change occurs also in the proportion of different fibre types of the muscles, in the muscle with tendinous injury a predominance of type II fibre becoming apparent. Among the proteins of myofibrils a product of disintegration of a molecular weight of 31 000 can be consequently demonstrated, and in some muscles products of disintegration with a molecular weight between 90 000 and 58,000 arise.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D000368:Aged; D003285:Contractile Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000648:ultrastructure*; D009210:Myofibrils / Q000378:metabolism / Q000648:ultrastructure; D012421:Rupture; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013708:Tendon Injuries / Q000378:metabolism / Q000473:pathology*
chemical_list: D003285:Contractile Proteins; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases