[Effect of platinum and palladium compounds on mitochondrial enzymatic systems].
Effect of platinum and palladium complexes on respiration and ATPase activity in bovine heart tissue as well as on respiration of submitochondrial particles was studied. The highest inhibitory activity was exhibited by the complexes of platinum and palladium with pi-ligands in internal coorhdinational sphere such as ethylene-C H4, norbornadiene-C7H8 and allyl-C3H5. The electron density at the central atom of the complex was not responsible for the inhibitory affect of platinum and palladium on mitochondria.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D003864:Depression, Chemical; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010165:Palladium / Q000494:pharmacology*; D010984:Platinum / Q000494:pharmacology*; D051381:Rats; D012995:Solubility
D008024:Ligands; D010984:Platinum; D010165:Palladium; D000251:Adenosine Triphosphatases
Vliianie soedineniĭ platiny i palladiia na fermentnye sistemy mitokhondriĭ.