Further studies on the inheritance of responsiveness to pertussis HSF in mice.
Inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli (HSF) was investigated in (C3H/HeJ times C57BL/6J)F1 hybrids, backcross progeny of this hybrid to C57BJ/6J parent (C3H/HeJ times DBA/2J)F1 hybrids, and in backcross progeny of this hybrid to DBA/2J parent. It was found that transmission is not by virtue of a single autosomal dominant gene, as has been postulated. Rather, inheritance of responsiveness to HSF is far more complex, probably involving polygenic transmission.
D000818:Animals; D000942:Antigens, Bacterial; D001886:Bordetella pertussis / Q000276:immunology*; D005260:Female; D006632:Histamine / Q000276:immunology*; D007114:Immunization; D007117:Immunization, Secondary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014917:Whooping Cough / Q000235:genetics*
D000942:Antigens, Bacterial; D006632:Histamine