title: The effect of angiotensin infusion, sodium loading and sodium restriction on the renal and cardiac adrenergic nerves.
abstract: The renal and cardiac adrenergic nerve patterns in rats infused with large and small amounts of angiotensin and in rats given NaCl plus DOCA, NaCl alone, and salt-free diets were examined by the histochemical fluorescence method. Infusion of small amounts of angiotensin led to a persistent blood pressure elevation whereas infusion of large amounts of angiotensin resulted in a transient rise in blood pressure, probably due to the development of tachyphylaxis. Nerve patterns were found to be normal in angiotensin-infused rats and in rats given NaCl. In rats given NaCl plus DOCA and in rats subjected to salt restriction, a partial or complete disappearance of the transmitter of the adrenergic nerve terminals were recorded. The findings suggest that angiotensin in itself is incapable of inducing visible alterations in the transmitter content of the terminals. The findings agree with the view that angiotensin potentiates a norepinephrine depletion of the terminals during sympathetic activity, since it can be assumed that increased plasma angiotensin levels as well as various degrees of increased sympathetic tonus were present in the rats subjected to salt restriction. The similar effect on the nerve terminals produced by the combined NaCl and DOCA administration is consistent with earlier reports of an increased turnover of norepinephrine in animals thus treated.
mesh_terms: D000804:Angiotensin II / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology; D004039:Diet, Sodium-Restricted; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D007668:Kidney / Q000294:innervation*; D009411:Nerve Endings / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000804:Angiotensin II; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009638:Norepinephrine