Immune complex disease associated with Peroben intake.
The clinical history and biological investigations of a patient presenting an immune complex disease induced by Peroben are reported. Biological signs were those of a drug-induced lupus syndrome. A provocation test allowed disclosure of its pathomechanism, since during Peroben intake a high C1q binding activity occurred and later regressed, while deposits of IgM and C3 were evidenced in the vessel walls. Complete or partial thrombosis succeeded accompanying a leukocytoclastic vasculitis.
D000328:Adult; D003176:Complement C3 / Q000032:analysis; D004155:Diphenhydramine / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007105:Immune Complex Diseases / Q000139:chemically induced* / Q000473:pathology; D007075:Immunoglobulin M / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced; D011728:Pyridones / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D013927:Thrombosis / Q000139:chemically induced; D014657:Vasculitis / Q000139:chemically induced
D003176:Complement C3; D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D007075:Immunoglobulin M; D011728:Pyridones; C008814:peroben; D004155:Diphenhydramine