Effect of cordycepin on the replication of type-c RNA tumor viruses.
Cordycepin (3'-deoxyadenosine) was previously shown to inhibit virus production induced by iododeoxyuridine from murine fibroblasts (Wu et al., 1972). We now report that the inhibitory effect of cordycepin results in a reduction of the number of cells producing virus as measured by the infectious center assay and fluorescent antibody technique. Cordycepin has a much greater inhibitory effect on viral replication than on transformation of normal rat kidney cells by murine sarcoma virus since viral production was greatly reduced (seven- to 35-fold) with 5-10 mug/ml of cordycepin while viral transformation was only slightly inhibited (two-fold reduction in focus-forming units) with the same concentration of cordycepin. Inhibition of viral production is most effective if the compound is present during the first 24 h after injection.
D000818:Animals; D000951:Antigens, Neoplasm; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003601:Cytotoxicity Tests, Immunologic; D003839:Deoxyadenosines / Q000494:pharmacology*; D003864:Depression, Chemical; D017988:Gammaretrovirus / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus / Q000187:drug effects; D051381:Rats; D011925:Rauscher Virus / Q000187:drug effects; D012190:Retroviridae / Q000187:drug effects*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
D000951:Antigens, Neoplasm; D003839:Deoxyadenosines