Granulocytic chalone is not a polyamine complex.
Recent studies have indicated that tissue extracts may contain sufficient amounts of free polyamines to account for the inhibitory effect of the extracts and hence mask any authentic chalone action. It has also been reported that bound polyamine may be the active moiety of some chalones. We show here that in our granulocytic and lymphocytic chalones polyamines, either free or bound, are not responsible for the inhibitory effects of the preparation.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D006098:Granulocytes / Q000032:analysis*; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210 / Q000378:metabolism; D007942:Leukemia, Experimental / Q000378:metabolism; D051379:Mice; D011073:Polyamines / Q000032:analysis* / Q000494:pharmacology; D051381:Rats; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D006131:Growth Inhibitors; D011073:Polyamines; D013096:Spermine; D013095:Spermidine; D013936:Thymidine