title: Receptor-active growth hormone in Laron dwarfism.
abstract: The hepatic radioreceptor assay for hGH has been applied to the detection of hGH in the sera of patients with high growth hormone dwarfism (Laron dwarfism). Substantial quantities of receptor-active hGH were found in the sera of all 7 patients studied. In one patient, arginine infusion elicited a prompt increase in both immunoactive and receptor-active hGH. These observations suggest that circulating hGH in Laron dwarfism is biologically active and support the concept that the disease may be caused by a generalized defect in hGH receptors.
mesh_terms: D001120:Arginine / Q000494:pharmacology; D004392:Dwarfism / Q000503:physiopathology*; D013006:Growth Hormone / Q000097:blood* / Q000502:physiology; D006801:Humans; D011869:Radioligand Assay; D011956:Receptors, Cell Surface
chemical_list: D011956:Receptors, Cell Surface; D013006:Growth Hormone; D001120:Arginine