[Action of polymethylene-bis-quaternary compounds on the muscarinic and nicotinic cholinoreceptors].
The action of compounds with general formula (formula: see text) on the frog heart ventricle, cat blood pressure, guinea pig ileum and frog rectus abdominis was studied. With dioxolane radicals (type F-2268) a strong muscarinomimetic action on the cat arterial blood pressure and guinea pig ileum was observed, with maximum marked action at n = 10, which was more pronounced at an even than at odd number of methylene groups. On the frog heart the compounds with an odd number of "n" elicited an atropine-like action. The compounds with pentyl radicals produced no effect on blood pressure and a weak cholinolytic effect on the frog heart. On the ileum they exhibited a cholinomimetic effect. All compounds studied acted as noncompetitive cholinolytics on the frog rectus.
D000009:Abdominal Muscles / Q000187:drug effects; D000818:Animals; D001001:Anura; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic
Deĭstvie nekotorykh polimetilen-bis-chetvertichnykh soedineniĭ na muskarinovye i nikotinovye cholinoretseptory.