Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes.
Splenic leukocytes from rabbits immunized with herpes simplex virus (HSV) incorporated significant amounts of 3H-TdR and produced interferon after in vitro incubation with  HSV antigens. In contrast, splenic leukocytes from nonimmune rabbits did not incorporate 3H-TdR or produce interferon when incubated with HSV antigens. Antigen-antibody complexes consisting of HSV antigens and anti-HSV antibody also were capable of stimulating immune leukocytes to incorporate 3H-TdR and to produce interferon.
D000818:Animals; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D007372:Interferons / Q000096:biosynthesis*; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009500:Neutralization Tests; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification; D014721:Vesicular stomatitis Indiana virus / Q000302:isolation & purification
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D037102:Lectins; D007372:Interferons