title: Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure.
abstract: Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.
mesh_terms: D000208:Acute Disease; D002130:Calcium Phosphates / Q000378:metabolism; D002805:Chondrocalcinosis / Q000188:drug therapy / Q000209:etiology*; D003460:Crystallization; D011756:Diphosphates / Q000378:metabolism; D004492:Edetic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000378:metabolism; D008278:Magnesium Sulfate / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012995:Solubility; D013582:Synovial Fluid / Q000032:analysis; D007507:Therapeutic Irrigation / Q000009:adverse effects
chemical_list: D002130:Calcium Phosphates; D011756:Diphosphates; D008278:Magnesium Sulfate; D004492:Edetic Acid