Galactose metabolism in relation to cataract formation in marsupials.
Erythrocytic galactokinase and/or galactose-1-phosphate uridyl transferase activity were low in many species of marsupials. However, cataract formation was observed only in pouch-young members of these species when reared on cow's milk. The galactose tolerance of young kangaroos was found to be greatly impaired, but improved rapidly and markedly at the stage of which the definitive structure of the ruminant type of stomach as in adults is formed. The combination of high absorption of galactose and low levels of galactokinase and/or transferase thus appears to determine the predisposition of pouch-young marsupials to galactose cataractogenesis.
D000328:Adult; D000367:Age Factors; D000818:Animals; D002386:Cataract / Q000209:etiology* / Q000662:veterinary; D002417:Cattle; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000201:enzymology; D005690:Galactose / Q000378:metabolism*; D005693:Galactosemias; D006801:Humans; D007614:Macropodidae / Q000097:blood; D008394:Marsupialia / Q000378:metabolism*; D008892:Milk; D010770:Phosphotransferases / Q000097:blood; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000097:blood
D010770:Phosphotransferases; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase; D005690:Galactose