The kininase activity of Ehrlichs' ascites solid tumor after treatment with oncolytic clostridia.
For the first time the effect of bacterial kininases of Cl. oncolyticum M 55 ATCC 13.732 could be demonstrated in the tumor itself. This is shown by an increased degradation of kinins by spore-treated tumor tissue in comparison with respective controls. The results indicate the influence of kininases on the capillary circulation of the tumor tissue as one of the fundamental reactions of oncolysis.
D000818:Animals; D002268:Carboxypeptidases / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D003013:Clostridium; D005260:Female; D001121:Lysine Carboxypeptidase / Q000378:metabolism*; D051379:Mice; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D013171:Spores, Bacterial
D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase