The factors controlling stem cell recirculation. II. ACTH-induced inhibition of migration of hemopoietic stem cells.
Injections of ACTH of prolonged action (twice 1.5 units per mouse) given to lethally (800 R) irradiated mice with a hind limb shielded to the middle of the tibia brought about a twofold decrease in the number of spleen colonies. ACTH injections after sublethal whole-body irradiation (600 R) did not affect the number of endogenous spleen colonies. ACTH injection of normal mice brought about a substantial decrease in the CFU content in the circulating blood at the time of increased 11-hydroxycorticosteroid concentrations in the plasma. The results obtained are interpreted as inhibition of CFU migration from a shielded area of bone marrow induced by a high 11-hydroxycorticosteroid content in the plasma that followed ACTH injections which had no mitostatic effect on CFU proliferation.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division; D002465:Cell Movement / Q000187:drug effects; D005470:Fluorometry; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006614:Hindlimb; D051379:Mice; D011827:Radiation; D011835:Radiation Protection; D013154:Spleen / Q000166:cytology; D013977:Tibia
D015062:11-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone