Local antitumor activity of a primary and an anamnestic response to a syngeneic guinea pig hepatoma.
After intradermal (id) injection, the line-10 hepatoma grew progressively in nonimmune guinea pigs, whereas the line-1 hepatoma grew for approximately 2 weeks, developed central necrosis, ulcerated, and regressed. Growth of the line-10 hepatoma was suppressed when line-10 hepatoma cells were mixed with antigenically distinct line-1 hepatoma cells before id injection into syngeneic strain-2 guinea pigs. Mixture of line-10 with irradiated line-1 or viable strain-2 embryo cells did not inhibit tumor growth. Preimmunization of recipients to line-1 cells abrogated the suppression of tumor growth from mixtures of line-1 and line-10.
D000818:Animals; D000951:Antigens, Neoplasm; D006528:Carcinoma, Hepatocellular / Q000276:immunology* / Q000517:prevention & control; D002460:Cell Line; D006168:Guinea Pigs; D007114:Immunization; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D008113:Liver Neoplasms; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology / Q000517:prevention & control
D000951:Antigens, Neoplasm