Immunopathology of mouse hepatitis virus type 3 infection. III. Clinical and virologic observation of a persistent viral infection.
Three types of viral sensitivity were observed in various mouse strains upon MHV3 infection: resistance, full susceptibility, and semisusceptibility. In the latter type, seen in several inbred strains including C3H, approximately 50% of the adult injected animals resisted to the acute disease. Most of the surviving mice, however, developed a chronic disease with a wasting syndrome and occurrence of paralysis. The chronic period of the disease was characterized by a persistent viral infection, since MHV3 virus was recovered from brain, liver, spleen, and lymph nodes throughout the evolution in most of the animals. In addition, a correlation was observed between the clinical evolution and the titer of virus tested 4 days after infection.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000382:microbiology; D002908:Chronic Disease; D005260:Female; D006520:Hepatitis, Animal / Q000150:complications / Q000276:immunology*; D007928:Lethal Dose 50; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D006517:Murine hepatitis virus / Q000276:immunology* / Q000302:isolation & purification; D010243:Paralysis / Q000209:etiology; D012376:Rodent Diseases / Q000276:immunology; D013154:Spleen / Q000382:microbiology