Hemolytic anemia induced by murine erythroblastosis virus: possible mechanisms of hemolysis and effects of an interferon inducer.
Murine erythroblastosis virus (MuEV), also called murine leukemia virus-Kirsten, is a member of the murine type-C-RNA leukemia-sarcoma group of oncogenic viruses. Like other members of this group, MuEV can elicit both a hemolytic disorder and an oncogenic response. Neonatal rats infected with MuEV succumb to this hemolytic disorder unless they are treated with the synthetic double-stranded polyribonucleotide, polyinosinic-polycytidylic acid (poly I-poly C). Animals receiving poly I-poly C had markedly reduced levels of virus reproduction as measured by bioassay and electron microscopy. The proliferation of erythroblasts after MuEV infection in animals not receiving poly I-poly C appeared to be an erythropoietin-dependent compensatory response to hemolysis. The hemolysis itself seemed to require virus reproduction in the cell types affected. Administration of poly I-poly C to MuEV-infected rats inhibited virus reproduction and thus may circumvent the hemolytic disease syndrome. The ultrastructure of the virus and of the virus reproduction was also studied.
D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D000818:Animals; D001792:Blood Platelets / Q000382:microbiology; D004900:Erythroblasts / Q000382:microbiology; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006461:Hemolysis / Q000187:drug effects; D007372:Interferons / Q000097:blood; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000302:isolation & purification / Q000648:ultrastructure; D008297:Male; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology*; D051381:Rats; D011920:Rats, Inbred WF; D012190:Retroviridae / Q000187:drug effects / Q000302:isolation & purification / Q000648:ultrastructure; D013154:Spleen / Q000473:pathology; D014412:Tumor Virus Infections / Q000150:complications*; D014779:Virus Replication / Q000187:drug effects
D004921:Erythropoietin; D007372:Interferons; D011070:Poly I-C