Vitamin d and the kidney.
The biologically active form of vitamin D3, 1,25-dihydroxycholecalciferol is produced by the kidney. The biosynthesis of 1,25-dihydroxycholecalciferol from 25-hydroxycholecalciferol is apparently controlled and important factors in this control are dietary calcium and phosphorus, and parathyroid hormone secretion. The direct effects of vitamin D and its metabolites on renal function are uncertain. Patients with chronic renal failure have defective synthesis of 1,25-dihydroxycholecalciferol. Uremic patients treated with small doses of 1,25-dihydroxycholecalciferol or 1 alpha-hydroxycholecalciferol show increased intestinal calcium absorption and bone healing.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002762:Cholecalciferol / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007422:Intestines / Q000187:drug effects; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000502:physiology; D010758:Phosphorus / Q000502:physiology; D051381:Rats; D014511:Uremia / Q000188:drug therapy; D014807:Vitamin D / Q000378:metabolism*
D010281:Parathyroid Hormone; D014807:Vitamin D; D002762:Cholecalciferol; D010758:Phosphorus; D002118:Calcium