Coenzyme A requirement of malaria parasites: enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae.
Normal duck erythrocytes and erythrocytes infected with Plasmodium lopharae have all of the enzymes for coenzyme A biosynthesis, whereas parasites freed from their host cells have non. Since erythrocytefree cultivation of P. lophurae requires an exogenous source of coenzyme A, this parasite must obtain its coenzyme A entirely from the host cell during infection.
D000255:Adenosine Triphosphate; D000818:Animals; D002262:Carboxy-Lyases / Q000097:blood; D003065:Coenzyme A / Q000096:biosynthesis / Q000494:pharmacology*; D003545:Cysteine; D004912:Erythrocytes / Q000201:enzymology* / Q000378:metabolism / Q000382:microbiology; D009713:Nucleotidyltransferases / Q000097:blood; D010204:Pantetheine / Q000031:analogs & derivatives; D010205:Pantothenic Acid / Q000031:analogs & derivatives; D010453:Peptide Synthases / Q000097:blood; D010770:Phosphotransferases / Q000097:blood; D010961:Plasmodium / Q000187:drug effects*
D010205:Pantothenic Acid; D010204:Pantetheine; D000255:Adenosine Triphosphate; D010770:Phosphotransferases; D009713:Nucleotidyltransferases; D002262:Carboxy-Lyases; D010453:Peptide Synthases; D003545:Cysteine; D003065:Coenzyme A