Effect of the fungal toxin (zearalenone) on the reproductive system and fertility of male and female rats.
The fertility-inhibiting effects of long-term (8 weeks) consumption of maize infected with a fungus producing F2 toxin (zearalenone) was studied in adult male and female albino rats. The fertility rate was further decreased by 25-30% if the animals were kept on contaminated diet up to 14 weeks. The gonadal weight was decreased, follicular maturation and spermatogenesis were disturbed. The toxic diet consumed by mothers during pregnancy and lactation induced permanent changes in reproductive organs, disorders in vaginal cyclicity and disturbed fertility in the offspring. Neonatal administration of purified F2 toxin provoked similar changes. It is suggested that this fungal toxin may cause sterility syndrome in the offspring, similar to that produced by androgen or estrogen administration.
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D012118:Resorcinols / Q000494:pharmacology*; D012741:Sexual Maturation / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects*; D015025:Zearalenone / Q000494:pharmacology*
D012118:Resorcinols; D015025:Zearalenone