[Transplacental oncogenic effect of ethylnitrosourea in rabbits (author's transl)].
50 mg/kg ethylnitrosourea (ENU) per dose, diluted in a 0.9%NaCl/1%NaH2PO4 solution (pH 6.2) were administered intravenously to three pregnant rabbits. The injections were carried out on the following days of gestation: 21., 26., and 30./21., 25., and 31./22., 25., and 30. From the total offspring (22), 16 rabbits could be raised. In 12 animals, kidney tumours were observed after a latent period of 2--2 1/2 years. The induced tumours are generally composed of both epithelial and mesenchymal tissue elements. Two tumours of the series are of a pure epithelial or a pure mesenchymal nature respectively. In most of the mixed tumours, classified as Adenocarcino-Sarcomas (10), the epithelial and mesenchymal elements are closely integrated, sometimes one component predominated over the other one. Histologically the ENU-induced mixed tumours of kidney in rabbits and the "dysontogenetic" kidney tumours of children (WILMS) show comparable structural characteristics.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002296:Carcinosarcoma / Q000139:chemically induced; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D007680:Kidney Neoplasms / Q000139:chemically induced; D008431:Maternal-Fetal Exchange; D009369:Neoplasms / Q000196:embryology*; D009373:Neoplasms, Germ Cell and Embryonal / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011247:Pregnancy; D011817:Rabbits; D012509:Sarcoma / Q000139:chemically induced; D013997:Time Factors
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea
Oncogene Wirkung von Athylnitrosoharnstoff beim kaninchen während der pränatalen Periode