Human fibroblast and leukocyte interferons show different dose-response curves in assay of cell protection.
Preparations of human fibroblast and leukocyte interferons of similar potency show markedly different dose-response curves in an assay which measures the degree of protection of tissue cultures against virus c.p.e. The effect is observed with both vesicular stomatitis virus (VSV) and Mengovirus, and is not altered by purification of the interferons.
D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007202:Indicators and Reagents; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000378:metabolism; D008574:Mengovirus / Q000187:drug effects / Q000254:growth & development*; D009499:Neutral Red; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development*
D007202:Indicators and Reagents; D009499:Neutral Red; D007372:Interferons