Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist.
The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5). PRL levels rose significantly in a dose-dependent fashion within a 120-min time interval. GH rose significantly but modestly over the same time interval, whereas TSH and cortisol levels remained unchanged. Since muscimol is thought to be a potent and specific gamma-aminobutyric acid agonist, these data indicate that gamma-aminobutyric acid-mediated neural transmission may function to stimulate the release of plasma PRL and GH in human subjects.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006816:Huntington Disease / Q000097:blood*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D012559:Schizophrenia / Q000097:blood*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D011388:Prolactin; D013006:Growth Hormone