title: Different patterns of polyadenylation of rhinovirus: specified RNA during multiplication in human aneuploid and diploid cells.
abstract: The polyadenylation of rhinovirus-specified RNA in aneuploid HeLa cells and diploid human embryo lung (HEL) cells has been investigated. Polyadenylation occurs at a faster rate and more extensively to virus-specified RNA in infected HEL cells compared with HeLa cells. Poly(A) is added post-transcriptively in both cell types. Furthermore the addition of adenosine or poly(A) during virus multiplication increases the polyadenylation of virus single-stranded RNAs in both cell types, but to a greater extent in HeLa cells.
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000782:Aneuploidy; D001483:Base Sequence; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D008168:Lung / Q000196:embryology; D011061:Poly A / Q000032:analysis* / Q000378:metabolism; D011123:Polyploidy; D012367:RNA, Viral / Q000032:analysis* / Q000096:biosynthesis; D012229:Rhinovirus / Q000032:analysis* / Q000254:growth & development / Q000378:metabolism; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D011061:Poly A; D000241:Adenosine