title: [Decurarization using the cation-anion molecular interaction of a myorelaxant and its antagonist].
abstract: In experiments on the cat neuromuscular preparation the authors investigated the anticurare action of the new compound IEM-931 having sulphonate-anionic groups 20 A apart. The new compound administered in a dose of 184 mkM/kg prevents and removes the curare effect of rythetronium which is its structural analogue. Regarding tubocurarine the antagonism is displayed, however, only from the dose of 384 mkM/kg. This indicates that efficacy of the anticurare action of IEM-931 is directly related to complimentarity of the interacting molecule structure. The experiment with regional relaxation of the cat muscles shows that the anticurare action of IEM-931 is realized both in the blood and on the cholinoreceptor. Moreover, as a result of molecular interaction the inactive complex is formed.
mesh_terms: D000818:Animals; D000838:Anions; D002412:Cations; D002415:Cats; D004347:Drug Interactions; D004558:Electric Stimulation; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D000838:Anions; D002412:Cations; D009125:Muscle Relaxants, Central; D009281:Naphthalenes; D003473:Neuromuscular Nondepolarizing Agents; D010880:Piperidines; D014403:Tubocurarine
vernacular_title: Dekurarizatsiia s pomoshch'iu kationno-anionnogo vzaimodeĭstviia molekul miorelaksanta i ego antagonista.