title: Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.
abstract: A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F enzyme is inactivated rapidly at 40 C, ADH 7lk is still active. Also, ADH S is not inactivated at this temperature, but has a far lower activity per fly than ADH 7lk. Genetic analysis showed that the new variant is an allele of the Adh locus.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D000431:Ethanol / Q000494:pharmacology; D014644:Genetic Variation; D007700:Kinetics; D009243:NAD / Q000494:pharmacology; D011995:Recombination, Genetic; D013696:Temperature
chemical_list: D009243:NAD; D000431:Ethanol; D000429:Alcohol Oxidoreductases