title: The effect of steroids on the extravascular distribution of radiographic contrast material and technetium pertechnetate in brain tumors as determined by computed tomography.
abstract: The effect of dexamethasone on the accumulation of iothalamate and 99mTc pertechnetate in cerebral tumors was investigated in 6 patients over a five-month period. Patients were examined by x-ray (transmission) computed tomography (CT) and by radionuclide (emission) computed tomography (RCT) prior to and during a course of dexamethasone therapy. Stenosis diminished the degree of accumulation of both agents but did not change the boundaries of their distribution.
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002648:Child; D003201:Computers; D003287:Contrast Media; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005909:Glioblastoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007483:Iothalamic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013667:Technetium / Q000378:metabolism*; D014056:Tomography, X-Ray
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; D013667:Technetium; D003907:Dexamethasone