Effect of partial thyroidectomy, propylthiouracil or thyroxine on estrogen-induced intranuclear inclusions in mammotrophs of the Mongolian gerbil.
Partial thyroidectomy caused a significant increase in the number of intranuclear inclusions per field (2-83 +/- 0-10 inclusions as compared with 0-15 +/- 0-03 inclusions for sham-controls). The inclusions occurred exclusively within mammotrophs. Thyrotrophs were stimulated: an increased cell size, numerous secretory granules, an enlarged Golgi apparatus and hypertrophic rough endoplasmic reticulum. Propylthiouracil caused similar ultrastructural changes although sighificantly fewer inclusions were observed (0-64 +/- 0-06 inclusions). Suppression of thyroid function with thyroxine produced no change in the number of inclusions (0-17 +/- 0-03 inclusions) although when combined with estrogen there were significantly fewer inclusions (1-62 +/- 0-07) when compared to estrogen alone (2-69 +/- 0-09). Intranuclear inclusions appear to be a unique reaction of mammotrophs to cellular hyperfunction in the Mongolian gerbil.
D000818:Animals; D001835:Body Weight; D002462:Cell Membrane / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005849:Gerbillinae / Q000502:physiology*; D006056:Golgi Apparatus / Q000648:ultrastructure; D002479:Inclusion Bodies / Q000187:drug effects / Q000648:ultrastructure; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000648:ultrastructure*; D009929:Organ Size; D011441:Propylthiouracil / Q000494:pharmacology*; D013961:Thyroid Gland / Q000502:physiology* / Q000648:ultrastructure; D013974:Thyroxine / Q000494:pharmacology*
D004967:Estrogens; D011441:Propylthiouracil; D013974:Thyroxine