[The damaging effect of the sodium salt of nystatin on ascitic tumor cells].
The experiments in vitro have demonstrated that an application of 0.1 mg/ml of nistatine into ascitic cells suspension would result in swelling of cells and 80% loss of intracellular potassium, associated with a considerable reduction of Na+K+-ATP-ase activity, the intensity of respiration and glycosis being changed but insignificantly. Thus, the influence of a polyene antibiotic - nistatine on the water-salt balance of ascitic cells under study is likely to be somewhat related with inhibition of NA+K+-dependent ATP-ase.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic; D001202:Ascitic Fluid; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D005260:Female; D006019:Glycolysis; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D009761:Nystatin / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010101:Oxygen Consumption; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D009761:Nystatin; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium
O povrezhdaiushchem deĭstvii natrievoĭ soli nistatina na kletki astsitnykh opukholeĭ