Thrombogenic potential of dacron grafts after prior exposure to whole blood, plasma, or albumin.
On hundred forty six (146) vascular graft insertions have been examined to determine the best exposure media, the mode of exposure, and the time of exposure required to change the TP of knitted dacron fabric. Whole blood, plasma, albumin, and Ringer's lactate (as control) were the media used. The mode of exposure was by either simple soaking or physiological perfusion with the appropriate media. The time of exposure was from one hour to 7 days. Simple soaking in species-specific albumin was found to be highly effective in lowering the TP of knitted dacron and we advocate this as the initial step in preclotting dacron grafts. This step is equally critical in the smaller vascular replacements and should lead to improved patency of these dacron vascular grafts.
D000818:Animals; D001790:Blood Physiological Phenomena; D001807:Blood Vessel Prosthesis; D004285:Dogs; D007773:Lactates / Q000494:pharmacology; D010949:Plasma / Q000502:physiology*; D011093:Polyethylene Terephthalates / Q000494:pharmacology*; D012709:Serum Albumin / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology*
D007773:Lactates; D011093:Polyethylene Terephthalates; D012709:Serum Albumin; D012965:Sodium Chloride