The effect of combined chronic hypoxia and N-ethyl-N-nitrosourea on the carotid bodies of rats.
We measured the carotid body volume of rats treated with chronic hypoxia alone and chronic hypoxia together with a single neonatal injection of N-ethyl-N-nitrosourea (10 mg/kg). All the animals so treated showed enlargement of their carotid bodies, but no carotid body chemodectomas occurred.
D000818:Animals; D000831:Animals, Newborn; D001932:Brain Neoplasms / Q000209:etiology; D002344:Carotid Body / Q000187:drug effects / Q000502:physiology*; D002345:Carotid Body Tumor / Q000209:etiology; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D006984:Hypertrophy; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D010236:Paraganglioma, Extra-Adrenal / Q000209:etiology; D051381:Rats
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea