title: Phagocytosis of chromium during patellar osteoarthritic remodelling associated with a knee prosthesis.
abstract: The report is of an anatomico-pathological and electron probe microanalyzer study of a patella with osteoarthritic remodelling, that had been in contact with a cast cobalt-chromium-molybdenum prosthesis for two years and seven months. Abrasion of the metal resulted in preferential phagocytosis of chromium, principally in the wall of an osteoarthritis cyst. This observation indicates that a substance administered by intra-articular pathway for the treatment of osteoarthritis can become phagocytosed, and quite deeply, in the remodelled bone.
mesh_terms: D000368:Aged; D002857:Chromium; D005260:Female; D006801:Humans; D007595:Joint Prosthesis; D007719:Knee Joint; D010003:Osteoarthritis / Q000473:pathology*; D010329:Patella / Q000473:pathology*; D010587:Phagocytosis
chemical_list: D002857:Chromium