Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma.
The metabolism of 7alpha-3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5alpha-androstane-3alpha, 17beta-diol and 5alpha-androstane-3,17-dione. Of the tumors investigated, three estrogen receptor-negative tumors converted DHA to estradiol and only one estrogen receptor-positive tumor produced estradiol from DHA. Observations on the relationship of androgen metabolism and hormone dependency are discussed.
D015113:Androstane-3,17-diol / Q000096:biosynthesis; D000731:Androstanes / Q000096:biosynthesis; D001665:Binding Sites; D001943:Breast Neoplasms / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000096:biosynthesis; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D011485:Protein Binding; D011956:Receptors, Cell Surface; D013739:Testosterone / Q000096:biosynthesis
D000731:Androstanes; D011956:Receptors, Cell Surface; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol