Effect of acute inhibition of adrenocorticotrophin secretion on plasma corticosteroids in the rhesus monkey (Macaca mulatta).
The half-life of plasma cortisol in the rhesus monkey (M. mulatta), determined by two methods, was about 130 min and longer than that in man; it was unaffected by administration of dexamethasone. Dexamethasone (5 mg, i.v.) immediately inhibited the secretion of ACTH from the monkey pituitary. The plasma half-life of NH2-terminal immunoreactive ACTH was found to be about 55 min which was much longer than the biological half-life. The adrenal synthesis of cortisol was inhibited by metyrapone which caused a prompt increase in the plasma concentration of ACTH and 11-deoxycortisol. The hypothalamic-pituitary-adrenal system of the rhesus monkey sedated with phencyclidine hydrochloride responded rapidly to alteration in the level of steroids in the circulation.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000311:Adrenal Glands / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000758:Anesthesia; D000818:Animals; D003350:Cortodoxone / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D000882:Haplorhini; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis / Q000097:blood*; D008251:Macaca / Q000097:blood*; D008253:Macaca mulatta / Q000097:blood*; D008797:Metyrapone / Q000494:pharmacology; D010622:Phencyclidine; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism
D015062:11-Hydroxycorticosteroids; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D010622:Phencyclidine; D003350:Cortodoxone; D006854:Hydrocortisone; D008797:Metyrapone