[Effect of phenobarbital stimulation on morphological and cytoenzymatic changes in the liver of benzene intoxicated rats (author's transl)].
The experiments were carried out on male Wistar-Rats. They were divided into 2 groups. The rats of the control groups were treated to Phenobarbital intraperitoneally for 3 consecutive days. The animals of the experimental group were additionaly injected with Benzen intraperitoneally on the 4th day of experiment. It has been found that Phenobarbital brought about the formation of 2 types of bright and dark cells in the liver. The action of Phenobarbital is carried on by Benzene. The authors discuss morphological and functional evaluation of bright and dark cells from the point of view of stimulating action of Phenobarbital as well as the course of Benzene biotransformation in liver cells.
D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D001554:Benzene / Q000378:metabolism / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000473:pathology; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005952:Glucose-6-Phosphatase / Q000032:analysis; D006651:Histocytochemistry; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D009246:NADH Tetrazolium Reductase / Q000032:analysis; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D009246:NADH Tetrazolium Reductase; D005952:Glucose-6-Phosphatase; D000251:Adenosine Triphosphatases; D001554:Benzene; D010634:Phenobarbital
Morphologische und cytoenzymatische Untersuchungen der mit Phenobarbital stimulierten Rattenleber bei experimenteller Benzolvergiftung