[Effect of methyl parathion and zineb administration on the activity of some hepatic enzymes in rats].
Male albinos rats were fed diets containing parathion-methyl or Zineb so that the average daily intake is 1/10 or 1/20 lethal dose 50, for a period of 4 or 8 weeks. The activity of hepatic microsomal enzymes, namely :aminopyrine N-demethylase, BHT oxidase, aniline hydroxylase, Butter Yellow & Amaranth reductases, NADPH-cyt. c reductase, G6P phosphatase, were measured. The activities of G6P & 6PG deshydrogenases were also determined. With the application of the parathion-methyl doses, the only effect showed is the lowering of the microsomal protein concentration.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008297:Male; D008743:Methyl Parathion / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009929:Organ Size; D010105:Oxygenases / Q000378:metabolism; D010278:Parathion / Q000031:analogs & derivatives*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013859:Thiocarbamates; D015038:Zineb / Q000494:pharmacology
D011506:Proteins; D013859:Thiocarbamates; D008743:Methyl Parathion; D010278:Parathion; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010105:Oxygenases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D009247:NADH, NADPH Oxidoreductases; D005952:Glucose-6-Phosphatase; D015038:Zineb
Influence de l'administration de parathion-méthyle ou de zinèbe sur l'activité de quelques enzymes hépatiques chez le rat