Carrier state of antibody and viruses in a mouse breeding colony persistently infected with Sendai and mouse hepatitis viruses.
In a large-scale mouse breeder colony persistently infected with Sendai and mouse hepatitis viruses, most adult breeders 8 wk or more of age were shown to have antibodies to both viruses when monitored over a periof of 20 mo. Antibody to Sendai virus, apparently transmitted from the dam, was detected in 76% and 2% of mice aged 3 and 4 wk. respectively, and 64% and 100% of mice aged 6 and 8 wk, respectively. By seroconversion of sentinel cage-mates, a Sendai virus-carrier state was demonstrated with 6-wk-old mice but not with those either 4 wk or 10 wk of age, suggesting that breeder candidates about 6 wk of age may play an important role in establishing and perpetuating Sendai infection in this breeding colony. With mouse hepatitis virus, however, mice aged 4 wk or older seem to be effective transmitters of the virus, while some of these mice were found to have antibody to the virus.
D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002353:Carrier State / Q000276:immunology / Q000635:transmission / Q000662:veterinary*; D005260:Female; D006520:Hepatitis, Animal / Q000276:immunology* / Q000635:transmission; D008297:Male; D051379:Mice / Q000276:immunology*; D006517:Murine hepatitis virus / Q000276:immunology*; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000635:transmission / Q000662:veterinary*; D012376:Rodent Diseases / Q000276:immunology* / Q000635:transmission
D000914:Antibodies, Viral