Experimental induction of hypoparathyroidism with parathyroid hormone antibodies.
This study describes the effect of a single injection of parathyroid hormone antiserum on the serum calcium, serum phosphate, urinary cyclic AMP, and urinary phosphate levels in the intact perfused rat. A significant decline in serum calcium level with concomitant elevation in serum phosphate level and decreased urinary excretion of phosphate and cyclic AMP was noted. These findings strongly suggest that a transient hypoparathyroid state was induced by the parathyroid hormone antiserum.
D000818:Animals; D002118:Calcium / Q000097:blood; D000242:Cyclic AMP / Q000652:urine; D004195:Disease Models, Animal; D007037:Hypothyroidism / Q000276:immunology*; D007106:Immune Sera; D008297:Male; D010281:Parathyroid Hormone / Q000276:immunology*; D010710:Phosphates / Q000032:analysis; D011863:Radioimmunoassay; D051381:Rats
D007106:Immune Sera; D010281:Parathyroid Hormone; D010710:Phosphates; D000242:Cyclic AMP; D002118:Calcium