title: [Effect of adenosine on phosphofructokinase and phosphoglycerate kinase of rat liver].
abstract: Effects of adenosine on purified rat liver phosphofructokinase and phosphoglycerate kinase activity were investigated in vitro. Stimulation by adenosine of the phosphofructokinase has been observed at low concentrations, but the activity was markedly inhibited at high concentrations. Adenosine was an inhibitor of the phosphoglycerate kinase : Lineweaver-Burk analysis indicated that adenosine inhibition was competitive with ATP and non competitive with 3-phosphoglycerate. An interpretation of these results is proposed.
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005994:Glycerophosphates / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D010732:Phosphofructokinase-1 / Q000378:metabolism*; D010735:Phosphoglycerate Kinase / Q000378:metabolism*; D051381:Rats
chemical_list: D005994:Glycerophosphates; D000255:Adenosine Triphosphate; D010732:Phosphofructokinase-1; D010735:Phosphoglycerate Kinase; D000241:Adenosine
vernacular_title: Effet de l'adénosine sur la phosphofructokinase et la phosphoglycérate kinase du foie de rat.