The response of the immature fowl to multiple injections of adrenocorticotrophic hormone.
1. Treating chicks, from 1 d or 5 weeks of age with ACTH three times weekly for 3 weeks depresses growth and causes adrenal hypertrophy at dose rates of 30 IU/kg or more, and depletion of adrenal cholesterol (greater than 10 IU/kg). 2. Treating chicks five times weekly at a dose rate of 30 IU/kg was as effective as a dose of 120 IU/kg three times weekly. 3. Plasma glucose and FFA concentrations of chicks treated thrice weekly with 120 IU ACTH/kg for 3 weeks were within the normal range. 4. Rhode Island Reds were more sensitive to ACTH than Light Sussex. 5. Adrenal cholesterol stores in normal chicks show significant variations with season.
D000311:Adrenal Glands / Q000032:analysis / Q000033:anatomy & histology / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002645:Chickens / Q000254:growth & development / Q000502:physiology*; D002784:Cholesterol / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D009929:Organ Size
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol; D001205:Ascorbic Acid