title: Regional curare for the reduction of the safety factor in human motor end-plates studied with single fibre electromyography.
abstract: A method employing six minutes of regional curarization with 0.5 mg D-tubocurarine and single fibre electromyographic measurements (SFEMG) was used in order to study the effect of an additional small dose of D-tubocurarine. The effect of the additional dose was most pronounced in terms of increased jitter, on motor end-plates with the initially highest jitter. The combination of regional curarization and SFEMG jitter recordings offers a sensitive technique for detecting mild effects of various drugs on neuromuscular transmission not detectable with decrement investigations.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D001132:Arm / Q000098:blood supply; D004305:Dose-Response Relationship, Drug; D004576:Electromyography / Q000379:methods*; D006801:Humans; D007275:Injections, Intravenous; D007511:Ischemia / Q000503:physiopathology; D008875:Middle Aged; D009045:Motor Endplate / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014403:Tubocurarine