Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group.
A cumulative dose-response curve for d-tubocurarine based on body weight was determined for 44 infants and children 1 day to 7 years of age during halothane, nitrous oxide and oxygen anesthesia. Depression of thumb adduction was measured. Age difference did not affect the mean dose-effect response. Infants less than 10 days old, however, showed the wideest deviation of responses. When the effect of d-tubocurarine is determined by twitch response, infants and children are more resistant to d-tubocurarine and recover faster than adults from similar levels of neuromuscular depression. Monitoring of neuromuscular function by train-of-four stimulation proved as useful as it is in adults.
D000367:Age Factors; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D009609:Nitrous Oxide / Q000008:administration & dosage; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors; D014403:Tubocurarine / Q000008:administration & dosage*
D009609:Nitrous Oxide; D006221:Halothane; D014403:Tubocurarine