title: Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.
abstract: Tetramethylenedisulphotetramine (TETS), a potent convulsant, antagonized the depolarizing action gamma-aminobutyric acid (GABA) in the isolated superior cervical ganglion of the rat. No antagonism of responses to the cholinomimetic agent carbachol was observed. TETS appeared to act in a non-competitive manner and was reversible. Its activity profile was comparable to that of bicuculline in the same tissue except that the latter appears to act in a competitive manner.
mesh_terms: D000613:Aminobutyrates / Q000037:antagonists & inhibitors*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001952:Bridged-Ring Compounds; D003292:Convulsants / Q000494:pharmacology; D018756:GABA Antagonists; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D009467:Neuromuscular Depolarizing Agents / Q000037:antagonists & inhibitors*; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D013450:Sulfones / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000613:Aminobutyrates; D001952:Bridged-Ring Compounds; D003292:Convulsants; D018756:GABA Antagonists; D009467:Neuromuscular Depolarizing Agents; D011073:Polyamines; D013450:Sulfones; D005680:gamma-Aminobutyric Acid; C010349:tetramethylenedisulfotetramine; D001640:Bicuculline