title: Granular layer induction following the topical application of proliferating agents.
abstract: Evidence is provided for a possible dermal influence on the epidermis. Topical vitamin A stimulates a number of dermal cells with different enzyme reactions, and these invade the epidermis at about the time a granular layer is induced in mouse tail scale epidermis. N-hexadecane also induced a granular layer formation in the tail scale epidermis but the application of this agent only results in the invasion of the epidermis by non-specific esterase cells. These non-specific esterase cells are present in the follicular zone where a granular layer is usually present. It appears that dendritic cells may be responsible for the formation of a granular layer and that these cells in some way influence the keratinocytes to discharge their lyosomal enzymes and thus form a granular layer. It appears unlikely that the dendritic cells actually contribute their own acid hydrolases to the cell cytolysis necessary for the production of granular layer.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000287:Administration, Topical; D000473:Alkanes / Q000494:pharmacology; D000818:Animals; D003033:Coal Tar / Q000494:pharmacology; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects* / Q000201:enzymology; D004950:Esterases / Q000378:metabolism; D006097:Granulation Tissue / Q000254:growth & development*; D007633:Keratins / Q000096:biosynthesis; D008297:Male; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000473:Alkanes; D014801:Vitamin A; D007633:Keratins; D003033:Coal Tar; D014442:Monophenol Monooxygenase; D004950:Esterases; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; C007932:n-hexadecane