Studies in type I glycogenosis: the paradoxical effect of ethanol on lactate.
Paradoxically, ethanol, which raises lactate in normal individuals, lowers the elevated levels of lactate in patients with Type I glycogenosis. We found that, although lactate levels fell, pyruvate proportionately declined even more, resulting in an increased L/P ratio which indicates that, as in the normal, the oxidation of ethanol had generated NADH. In type I glycogenosis, the increased level of pyruvate-lactate derives from glycogenolysis. We found that, despite continued glycogenolysis, ethanol had caused less pyruvate-lactate to form. The effect of an increased NADH/NAD+ ratio on the flow of carbon through the Embden-Meyerhof pathway could account for the finding, presumably by its effect on the oxidation-reduction couples with diversion of carbon toward formation of triglyceride rather than pyruvate-lactate.
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002250:Carbon Radioisotopes; D002648:Child; D002845:Chromatography; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005947:Glucose / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000188:drug therapy* / Q000378:metabolism; D006008:Glycogen Storage Disease / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D009243:NAD / Q000378:metabolism; D011773:Pyruvates / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002250:Carbon Radioisotopes; D007773:Lactates; D011773:Pyruvates; D014280:Triglycerides; D009243:NAD; D000431:Ethanol; D005947:Glucose; D000409:Alanine