Milk-ejecting and uterotonic activities of oxytocin analogues in rats.
The milk-ejecting activity of oxytocin analogues modified in the aminoterminal part of the molecule was determined in experiment on rats in vivo. As compared with oxytocin, the analogues did not have significantly higher milk-ejecting activity and there was no dissociation of the two basic oxytocin-like activities.
D000818:Animals; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008893:Milk Ejection / Q000187:drug effects*; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011956:Receptors, Cell Surface; D014590:Uterine Contraction / Q000187:drug effects*
D011956:Receptors, Cell Surface; D010121:Oxytocin