title: Altered surface topology and membrane functions of rat thymocytes eluted from nylon wool columns.
abstract: (1) Following incubation of thymocytes with nylon wool at 37 degrees C, the eluted cells showed an increase in the number of microvilli per cell and a concominant elongation of the microvilli (0.22 mum versus 1.15 mum. (2) Cyclic adenosine monophosphate (cylic AMP) levels were lowered by 30-50% in nylon wool-treated thymocytes. (3) Nylon wool-treated cells showed an impaired Na+-dependent amino acid transport system (2-aminoisobutyrate) whereas the Na+-independent amino acid transport system (1-aminocyclopentane-1-carboxylate) was unaffected.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D001693:Biological Transport, Active; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D000242:Cyclic AMP / Q000378:metabolism; D008854:Microscopy, Electron; D009757:Nylons; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism; D014935:Wool
chemical_list: D000596:Amino Acids; D009757:Nylons; D012964:Sodium; D000242:Cyclic AMP