title: [Determinant factor and pathogenesis of multiple sclerosis].
abstract: A clinico-epidemiological and genealogical analysis of 182 patients with disseminated sclerosis, living in climatogeographical conditions of Tadjikistan permits to assume that disseminated sclerosis is an exogenous intrauterine (but not hereditary!), acquired monoetiological disease. At the basis of the pathogenesis lies an ectodermal microdysgenesia with a selective lesion of the embryo oligodendroglia system and an eventual disturbance of postnatal myelinopoesis. This condition is due to an exogenous-mutagen (toxico-allergic) action of the respective climatogeographical regions of "risk" in relation to disseminated sclerosis.
mesh_terms: D002980:Climate; D005843:Geography; D006801:Humans; D009103:Multiple Sclerosis / Q000196:embryology / Q000453:epidemiology / Q000209:etiology*; D013620:Tajikistan; D014131:Trace Elements / Q000032:analysis; D014881:Water Supply / Q000032:analysis
chemical_list: D014131:Trace Elements
vernacular_title: O determiniruiushchem nachale i patogeneze rasseiannogo skleroza.