Focal decreased skeletal uptake secondary to metastatic disease.
Two cases are reported in which bone imaging with 99mTc-labeled phosphate compounds revealed localized areas of decreased uptake corresponding to osteolytic metastases on bone radiographs. These "cold" bone lesions, although infrequent, should be considered to avoid false negative interpretations.
D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011859:Radiography; D011877:Radionuclide Imaging; D013125:Spinal Neoplasms / Q000175:diagnosis