[Action of alpha-methyl-dopa on waking-sleep cycles in two inbred strains of mice, C57BR and C57BL/6 (author's transl)].
The effects of alpha-methyl-Dopa at several dose levels on waking-sleep cycle of 175 mice from two inbred strains (C57BR and C57BL/6) have been studied. The results showed that each dose (25, 50, 100, 200 and 400 mg/kg), of alpha-methyl-Dopa completely suppresses paradoxical sleep (PS), after a period of sedation. Duration of PS inhibition varied as a function of dose, time of injection, and strain of mice. Using a multiple injection schedule of one injection per day for 5 consecutive days, there was suppression of nocturnal PS followed at the 4th day by rebound during day light hours.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013045:Species Specificity; D014851:Wakefulness / Q000187:drug effects*
D008750:Methyldopa
Action de l'alpha-méthyl-dopa sur les rythmes veille-sommeil des souris C57BR et C57BL/6