Prolactin receptors in rat liver: possible induction by prolactin.
A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.
D000818:Animals; D004967:Estrogens / Q000494:pharmacology; D005246:Feedback; D005260:Female; D007016:Hypophysectomy; D007328:Insulin / Q000378:metabolism; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000502:physiology; D011388:Prolactin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface
D004967:Estrogens; D007328:Insulin; D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D011388:Prolactin