Cell-cycle, cell-shape mutant with features of the Go state.
A cold-sensitive mutant of CHO cells has features of "reverse transformation" at the non-premissive temperature of 33 degrees C. Cells accumulate at G1 with altered morphology and remain viable and quiescent for more than 40 d. Such cultures are synchronised by a temperature shift back to the permissive 39 degrees C.
D003994:Bucladesine / Q000494:pharmacology; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004261:DNA Replication; D008938:Mitosis; D009154:Mutation; D010641:Phenotype; D013696:Temperature
D003994:Bucladesine