Motor nerve conduction study in patients on diphenylhydantoin therapy.
Mean motor conduction velocity of posterior tibial nerves was significantly reduced in epileptic patients treated with diphenylhydantoin formore than 10 years or in patients with serum diphenylhydantoin level above 20 mug/ml. Subnormal serum folate was not responsible for this reduction and clinical peripheral neuropathy was infrequent.
D000293:Adolescent; D000328:Adult; D004827:Epilepsy / Q000188:drug therapy*; D005492:Folic Acid / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D010672:Phenytoin / Q000009:adverse effects* / Q000097:blood; D013997:Time Factors; D014805:Vitamin B 12 / Q000097:blood
D010672:Phenytoin; D005492:Folic Acid; D014805:Vitamin B 12