Carcinogenicity of 5-nitrofurans and related compounds with amino-heterocyclic substituents.
Carcinogenicity of eight 5-nitrofurans with heterocyclic substituents at the 2-position of the furan ring was investigated by feeding the chemicals to Sprague-Dawley female rats. N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide induced in 30 rats the highest incidence of tumors with the greatest number of tissues involved: forestomach squamous cell tumors (22), kidney pelvis transitional cell carcinomas (15), pulmonary alveolar cell carcinomas (16), hemangioendothelialsarcomas (20) of the intestine, mesentery, liver, lung, and pancreas, and a few tumors of other tissues. 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole, 2-amino-5-(5-nitro-2furyl)-1,3,4-oxadiazole, and trans-2-[dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole produced high incidences of mammary tumors. The other four 5-nitrofurans tested: N-[4-(5-NITRO-2-FURYL)-2-THIAZOLYL]ACETAMIDE;2,3,4-TRIFLUORO-N-[4-(5-NITRO-2-furyl)-2-thiazoly]acetamide;5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-ol; and N-( [3-(5-nitro-2-furyl)-1,2,4-oxadiazol-5-yl]methyl)acetamide were associated with tumor incidences of 40-60%. Two other chemicals were also tested: 2-Amino-5-nitrothiazole caused a low incidence of breast and kidney pelvis tumors, and 2-amino-4-(p-nitrophenyl)thiazole induced a high incidence of breast and salivary gland adenocarcinomas and lymphomas.
D000230:Adenocarcinoma / Q000139:chemically induced; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000139:chemically induced; D000284:Administration, Oral; D000588:Amines / Q000633:toxicity; D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D008643:Mesentery; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009581:Nitrofurans / Q000008:administration & dosage / Q000633:toxicity*; D010069:Oxadiazoles; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D051381:Rats; D012468:Salivary Gland Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced; D013830:Thiadiazoles
D000588:Amines; D002273:Carcinogens; D009581:Nitrofurans; D010069:Oxadiazoles; D013830:Thiadiazoles