Pimozide and p-chlorophenylalanine blockade in DL-amphetamine and pargyline-treated rats held at two environmental temperatures.
In rats, treated with DL-amphetamine + monoamine oxidase inhibitor, and held at an ambient temperature of 28.5 degrees C, hyperthermia was completely eliminated by treatment with pimozide + p-chlorophenyl-alanine. The same drugs markedly reduced the hypothermic effects in rats treated similarly at 4 degrees C. Results implied that serotoninergic and dopaminergic neurones were involved in the thermoregulatory effects of amphetamine.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology*; D005334:Fever / Q000503:physiopathology*; D008297:Male; D010293:Pargyline / Q000494:pharmacology*; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D013696:Temperature
D000662:Amphetamines; D010868:Pimozide; D010293:Pargyline; D010134:Fenclonine