[Post-heparin-lipolytic activity in acute ethanol-induced hyperlipoproteinemia (author's transl)].
Post-heparin lipolytic-activity (PHLA) was studied in 10 healthy volunteers ingesting 0.5 g of ethanol/kg body weight initially and 0.1 g/kg body weight and hour over 5 hours. This dose led to enhancement in plasma triglycerides to about 170% of the pre-ethanol values. PHLA was determined before, 15 min, 1 and 5 hours after intake of the initial dose and showed no significant changes. These findings are compared with the results of earlier investigations. It is concluded that acute ethanol induced hyperlipoproteinemia in healthy man seems to be due mainly to enhanced hepatic synthesis of triglycerides and release of very low density lipoproteins and not to decrease catabolism of triglyceride rich lipoproteins.
D000328:Adult; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced*; D007700:Kinetics; D008071:Lipoprotein Lipase / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*
D008079:Lipoproteins, VLDL; D014280:Triglycerides; D000431:Ethanol; D006493:Heparin; D008071:Lipoprotein Lipase
Postheparinlipolytische Aktivität bei akuter alkoholinduzierter Hyperlipoproteinämie