title: The third circulation revisited.
abstract: The author reviews modern information concerning the formation, flow and functions of the cerebrospinal fluid. Particular attention is given to the lymphatic-like features of the third circulation and to its importance as an internal milieu for nervous tissue.
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002415:Cats; D002552:Cerebral Ventricles / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000378:metabolism / Q000502:physiology; D002831:Choroid Plexus / Q000378:metabolism / Q000502:physiology / Q000601:surgery; D004727:Endothelium / Q000201:enzymology; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology; D050356:Lipid Metabolism; D008578:Meninges / Q000032:analysis; D010770:Phosphotransferases / Q000032:analysis; D011817:Rabbits; D012039:Regional Blood Flow; D012979:Sodium Radioisotopes / Q000378:metabolism; D013346:Subarachnoid Space / Q000378:metabolism
chemical_list: D012979:Sodium Radioisotopes; D010770:Phosphotransferases; D000086:Acetazolamide