[The functional state of the hypothalamo-hypophyseal system in tumors of the pituitary and diencephalic area].
A study was made of 38 persons, including 25--with acromegaly, 5--with chromophobic adenomas of the hypophysis, 3--with diencephalic tumours and 5 healthy individuals.  STH, TTH and ACTH were determined in the blood plasma with the aid of radioimmunological methods under basic conditions and L-DOPA loading (10 mg per 1 kg of weight) with insulin (0.10 U/kg).  There was an increase in the plasma content of STH, TTH and ACTH with a maximum 60 min after the administration of L-DOPA.  In the patients with acromegaly STH increased considerably, and in cases with chromophobic adenomas and diencephalic tumours--less.  ACTH level was also elevated.  STH and ACTH level rose after insulin hypoglycemia.  Possible mechanisms of a stimulating action of L-DOPA and insulin are discussed.
D000172:Acromegaly / Q000503:physiopathology; D000238:Adenoma, Chromophobe / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001932:Brain Neoplasms / Q000503:physiopathology*; D004027:Diencephalon; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin; D007980:Levodopa; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D007980:Levodopa; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013006:Growth Hormone
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