Neoplastic transformation of mouse embryo cells by virus released from tumorigenic mouse cells transformed by avian sarcoma virus B77.
Mouse C3H embryo cells were transformed in vitro by avian sarcoma virus Bratislava 77 (B77) released scantily from a mouse cell line transformed earlier by the same virus. B77 virus transformed C3H embryo cells contained B77 viral genome and were transplantable into syngeneic as well as allogeneic DBA/2J young mice in which autochthonous sarcomas were induced. Tumors in both strains of mice were virogenic. The probable reasons for an increased transformation capacity of B77 virus in mammals are discussed.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000254:growth & development*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D012513:Sarcoma, Experimental / Q000209:etiology; D014779:Virus Replication