The fine structure of meningiomas: an attempted classification.
We examined 23 meningiomas by electron microscopy. In each case it was possible to distinguish certain cells with epithelial features (desmosomes, microfliaments, interdigitating extensions) and others with fibroblastic features (collagen fibers). Others cells of transitional form were also seen. The proportion of these cellular types is variable, making it possible to classify meningiomas into seven types of progressing gradually from a purely epithelial type to a purely fibroblastic one.-We found no important ultrastructural abnormalities in the cells. These case reports confirm the uniqueness of meningiomas, which are composed of variously shaped cells but have their origin from a single cellular type. This has double potentiality for fibroblastic and epithelial differentiation.
D002454:Cell Differentiation; D003599:Cytoskeleton / Q000648:ultrastructure; D003896:Desmosomes / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008577:Meningeal Neoplasms / Q000648:ultrastructure*; D008579:Meningioma / Q000145:classification / Q000648:ultrastructure*; D008854:Microscopy, Electron