[Use of coulometric titration for elucidating the mechanism of the oxidation of 6-APA alkaline breakdown products by halogens].
Penaldinic acid and penicillamine were formed on alkali decomposition (1 N NaOH) of 6-APA for 20 minutes at room temperature, penicillamine being completely oxidized to disulphide by the air oxygen. Coulometric titration of the alkali decomposition products showed that generated chlorine in 0.5 N HCl solution or bromine in a week acid solution of KBr oxidized them with participation of 7 electrones. Generated iodine did not practically oxidize the 6-APA decomposition products during the coulometric titration.
D001966:Bromine; D002713:Chlorine; D002854:Chromatography, Paper; D004305:Dose-Response Relationship, Drug; D004572:Electrolysis / Q000379:methods*; D006219:Halogens / Q000378:metabolism*; D010084:Oxidation-Reduction; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D012972:Sodium Hydroxide / Q000378:metabolism; D013997:Time Factors
D006219:Halogens; D002713:Chlorine; D012972:Sodium Hydroxide; D010397:Penicillanic Acid; D001966:Bromine
Primenenie kulonemetricheskogo titrovaniia dlia vyiavleniia mekhanizma okisleniia produktov shchelochnogo razlozheniia 6-APK galogenami