Concurrent feline immune-complex nephritis. Tubular antigen-positive and renal amyloidosis.
We describe tubular antigen-positive immune-complex nephritis in a case of feline renal amyloidosis. Amyloid deposition was observed in mesangial area, and thickening of capillary walls was shown in the majority of the glomeruli. This case was also characterized with typical fluorescent granular depositions of cat IgG and C3 along the glomerular capillary walls as seen in human membranous glomerulonephritis. The fluorescent pattern of tubular antigen was identical with that of IgG and C3. Electron micrograph showed the thickening and irregularity of glomerular basement membranes, fusion of foot processes, and deposits of electron-dense or sometimes translucent materials, mostly in the intramembranous location. The causal sequence of the coincidental deposition of amyloid and immune complexes is discussed.
D000686:Amyloidosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000936:Antigen-Antibody Complex; D002371:Cat Diseases / Q000276:immunology / Q000473:pathology*; D002415:Cats; D005455:Fluorescent Antibody Technique; D007105:Immune Complex Diseases / Q000473:pathology / Q000662:veterinary*; D007136:Immunoglobulins; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D009393:Nephritis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins