Serotonin inhibition and sleep.
Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency toward a decrease in the number of intact sleep cycles. The relationship of these data to published reports on p-chlorophenylalanine is discussed.
D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008784:Methysergide / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects; D012702:Serotonin Antagonists; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages; D012895:Sleep, REM / Q000187:drug effects
D011941:Receptors, Adrenergic; D012702:Serotonin Antagonists; D008784:Methysergide