title: 7-Substituted theophyllines. Part I. Nicotinamide derivatives.
abstract: Some nicotinamides derived from 7-substituted theophyllines were prepared and pharmacologically screened. They showed a very low coronarodilatory activity, a remarkable antispastic activity and a low toxicity.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006633:Histamine Antagonists / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D008297:Male; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D006633:Histamine Antagonists; D009536:Niacinamide; D000628:Aminophylline; D013806:Theophylline; D000109:Acetylcholine