title: [An immunoelectrophoretic study of plasma lipoproteins in a case of familial deficiency of lecithin-cholesterol acyltransferase (author's transl)].
abstract: The lipid composition and apopeptide patterns of plasma LDL and VLDL have been studied in a patient with LCAT deficiency, using two-dimensional immunoelectrophoresis. After absorption of a fat meal an elevation of VLDL apopeptides C was observed. Apo-LDL also showed an abnormal relative increase of apo-C. After heparin-induced lipolysis, a shift of apo-C from chylomicra and VLDL to LDL was noticed by the striking increase of apo-C in this last lipoprotein class. In view of the present and previously published results the possible mechanisms involved in lipoprotein catabolism in LCAT deficiency are discussed.
mesh_terms: D000217:Acyltransferases / Q000172:deficiency*; D006801:Humans; D007122:Immunoelectrophoresis; D007863:Lecithin Cholesterol Acyltransferase Deficiency; D008052:Lipid Metabolism, Inborn Errors / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000276:immunology; D008079:Lipoproteins, VLDL / Q000097:blood* / Q000276:immunology
chemical_list: D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D000217:Acyltransferases
vernacular_title: Etude immunoélectrophorétique des lipoprotéines plasmatiques dans un cas de deficience familiale en lécithine-cholésterol acyltransferase