Insulin-induced augmentation of lymphocyte-mediated cytotoxicity.
Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.
D000818:Animals; D002860:Chromium Radioisotopes; D006152:Cyclic GMP / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D006084:Graft Rejection; D007111:Immunity, Cellular / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D007739:L Cells; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D016038:Skin Transplantation; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014184:Transplantation, Homologous
D002860:Chromium Radioisotopes; D007328:Insulin; D010277:Parasympathomimetics; D006152:Cyclic GMP