Synthesis and secretion of a large glycoprotein in the pars intermedia.
The biosynthesis, intracellular transport and release of [3-H]-leucine-containing secretory product has been followed in the pars intermedia of Xenopus laevis and, in particular, the synthesis and secretion of a large molecular weight glycoprotein secretory product was demonstrated. However, if Xenopus adrenocorticotrophin does contain a leucine residue the results obtained provided no support for the view that it serves as a precursor for melanocytestimulating hormone in this species.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D005260:Female; D005643:Fucose / Q000378:metabolism; D005944:Glucosamine / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis* / Q000378:metabolism; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D009074:Melanocyte-Stimulating Hormones / Q000096:biosynthesis; D010902:Pituitary Gland / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D014981:Xenopus / Q000378:metabolism*
D006023:Glycoproteins; D005643:Fucose; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D007930:Leucine; D005944:Glucosamine