Demonstration of a pituitary gonadotrophin hormone activity in the male foetal mouse.
The testosterone production by 18-days-old foetal mouse testis was measured in an organ culture system, by RIA in the culture medium. This production was time-dependent, and could be stimulated by ovine LH and age-matched foetal pituitary. The gonadotrophin activity derived from foetal pituitary appeared to be released into the culture medium as a limited reserve. These data clearly show that a biologically active gonadotrophin material is present in the pituitary of the 18-days-old mouse foetus.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003470:Culture Media; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D005865:Gestational Age; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D010902:Pituitary Gland / Q000196:embryology / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000502:physiology*; D011388:Prolactin / Q000494:pharmacology; D013737:Testis / Q000196:embryology / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis*
D003470:Culture Media; D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone