Vinblastine-induced ultrastructural changes in perisinusoidal cells of the rat liver.
Vinblastine, given intravenously to rats, leads to disappearance of microtubules, formation of paracrystalline inclusions and accumulation of fat droplets in the cytoplasm of the perisinusoidal cells of the liver suggesting that microtubules of the perisinusoidal cells play a role in lipid metabolism.
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D002479:Inclusion Bodies; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008870:Microtubules; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine