Triethyltin sulfate-induced neuropathy in rats. Electrophysiologic, morphologic, and biochemical studies.
Adult rats given high orally administered doses of triethyltin (TET) sulfate lost weight, developed hind limb wasting, and became paraplegic or quadriplegic within three weeks of intoxication. A 33% reduction in the motor nerve conduction velocity (MNCV) of the sciatic nerve in the absence of significant demyelination was observed. There was observed, however, intramyelinic edema formation and an increased number of axonal neurofilaments and neurotubules; changes that paralleled the decrease in MNCV during the period of intoxication. Although the animals became asymptomatic and the MNCV normalized within two to three weeks of discontinuing the TET intoxication, the intramyelinic vacuoles and the increased numbers of neurofilaments and neurotubules persisted.
D000818:Animals; D002784:Cholesterol / Q000032:analysis; D003094:Collagen / Q000032:analysis; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000032:analysis; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D013433:Sulfoglycosphingolipids / Q000032:analysis; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds
D009419:Nerve Tissue Proteins; D013433:Sulfoglycosphingolipids; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D003094:Collagen; D002784:Cholesterol