Ontogenesis of serotonergic systems in rat brain.
It was shown that the concentration of brain 5-HT rises slowly, reaching mature values by 80 days of age, while the catabolic product of 5-HT, i.e., 5-HIAA, drops from a high perinatal value to lower values by adulthood. This is indicated of poorly developed storage mechanisms at this early period in life. It was also shown that MAO develops at a rapid rate, acquiring mature values by 20 days. The activity of MAO towards substrates develops at different rates, although the general pattern of development is the same.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D001923:Brain Chemistry; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008995:Monoamine Oxidase / Q000032:analysis; D009244:NAD+ Nucleosidase / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000502:physiology*
D009419:Nerve Tissue Proteins; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008995:Monoamine Oxidase; D009244:NAD+ Nucleosidase