[Biochemical investigations of cancer cachexia: I. Tumour induced changes of glycogenolysis and gluconeogenesis of Walker carcinoma bearing rats (author's transl)].
Rats (weight 150-200 g) bearing Walker-carcinoma showed tumour size dependent hypoglycemia, diminished mobilization of glycogen following glucagon stimulation and elevated values of the enzyme activity of glucose-6-(P)-ase. A further hormonal stimulation of this enzyme activity towards the values observed in normal rats after betamethasone stimulation was not possible. The values of the enzyme fructose-1,6-di-(P)-ase in liver of tumour bearing rats equalled those found in normal controls and did not show any rise after application of betamethasone. The serum levels of free fatty acids did not show any difference between normal controls and tumour bearing rats, and displayed an equal rise after intensive stimulation of peripheral lipolysis.
D000818:Animals; D001623:Betamethasone / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002100:Cachexia / Q000378:metabolism; D002110:Caffeine / Q000494:pharmacology; D002279:Carcinoma 256, Walker / Q000150:complications / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology; D005943:Gluconeogenesis; D005947:Glucose / Q000494:pharmacology; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D007003:Hypoglycemia / Q000209:etiology / Q000378:metabolism*; D008053:Lipid Mobilization / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D002110:Caffeine; D006003:Glycogen; D005934:Glucagon; D001623:Betamethasone; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D005947:Glucose
Biochemische Untersuchungen zum Problem der Tumorkachexie. I. Tumorbedingte Veränderungen der Glykogenolyse und der Gluconeogenese beim Walker-Carcinom der Ratte