Adrenocortical hydroxylase deficiencies in acne vulgaris.
To investigate the possible occurrence of partial 11- or 21-hydroxylase deficiences in acne, an androgen-dependent disorder, 11 women with chronic nodulocystic acne were subjected to a 24-hr infusion of ACTH and their urine analyzed for tetrahydro S and pregnanetrio. The results obtained were compared to those found in 8 control women. Seven of the patients exhibited elevated excretion of either tetrahydro S or pregnanetriol, probably indicative of partial 11- or 21-hydroxylase deficiencies, respectively.
D000152:Acne Vulgaris / Q000201:enzymology*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone; D000328:Adult; D003350:Cortodoxone / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006801:Humans; D011279:Pregnanetriol / Q000378:metabolism; D013250:Steroid Hydroxylases / Q000172:deficiency*; D013739:Testosterone / Q000097:blood; D013760:Tetrahydrocortisol / Q000378:metabolism
D011279:Pregnanetriol; D013739:Testosterone; D013760:Tetrahydrocortisol; D000324:Adrenocorticotropic Hormone; D013250:Steroid Hydroxylases; D003350:Cortodoxone