The effect of pentobarbital on basal and ether-stimulated ACTH secretion in intact and adrenalectomized rats.
Pentobarbital in a dose of 3.5 mg/100 g b.w. did not suppress the high  basal a.m. levels of plasma ACTH in adrenalectomized male rats. In both intact and adrenalectomized rats prior administration of the drug slightly depressed the rise in plasma ACTH induced by 2.5 min of ether inhalation, but this depression is of questionable statistical significance.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D005019:Ethyl Ethers; D004986:Ether; D000324:Adrenocorticotropic Hormone; D010424:Pentobarbital