Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.
Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-buryl ketone (CH3COCH2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.
D000818:Animals; D001369:Axons / Q000473:pathology; D004781:Environmental Exposure; D006588:Hexanones / Q000378:metabolism / Q000506:poisoning*; D007659:Ketones / Q000506:poisoning*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009784:Occupational Diseases / Q000139:chemically induced; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D012997:Solvents / Q000506:poisoning*
D006588:Hexanones; D007659:Ketones; D012997:Solvents; C011269:2,5-hexanedione