Excision of viral DNA from host cell DNA after induction of simian virus 40-transformed hamster cells.
Simian virus 40-transformed hamster cells were induced to produce infectious virus by treatment with mitomycin C or gamma-irradiation. A portion of the simian virus-40 DNA, which is integrated into the host cell genome in uninduced cells, was recovered in a pool of relatively low-molecular-weight DNA early after induction treatment in the absence of DNA replication. The data indicte that excision of the viral genome occurs subsequent to the induction stimulus.
D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004273:DNA, Neoplasm / Q000032:analysis / Q000378:metabolism; D004279:DNA, Viral / Q000032:analysis / Q000378:metabolism*; D005720:Gamma Rays; D008937:Mitomycins / Q000494:pharmacology; D008970:Molecular Weight; D011830:Radiation Effects; D013539:Simian virus 40 / Q000032:analysis / Q000254:growth & development* / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects / Q000528:radiation effects
D004273:DNA, Neoplasm; D004279:DNA, Viral; D008937:Mitomycins