Metabolism of some ethylenediamine derivatives with antiarrhythmic properties. I. Absorption, distribution in tissues and excretion of 14-C labelled N, N'-bis-[3-(p-methoxyphenoxy)-2-hydroxypropyl]-ethylenediamine dimethanesulphonate (MK-142) in rats.
14-C labelled MK-142 (specific activity 2.875 muCi/mg) (1.762 mCi/mM) passes very rapidly from the blood stream to the majority of tissues since 5 min after the iv administration the blood contained only about 5% of the administered dose. The relatively high content of MK-142 in the myocardium as compared with its content in the skeletal muscles indicates a high affinity of the examined substance to the heart muscle. MK-142 is excreted via kidneys, alimentary tract and respiratory ways.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D005260:Female; D007408:Intestinal Absorption; D008297:Male; D008698:Mesylates / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D011412:Propanolamines / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D011485:Protein Binding; D051381:Rats
D000889:Anti-Arrhythmia Agents; D002250:Carbon Radioisotopes; D005029:Ethylenediamines; D008698:Mesylates; D011412:Propanolamines; C006054:MK 142