title: Myopathic changes at the end-plate region induced by neostigmine methylsulfate.
abstract: Administration of large dose of neostigmine caused very quickly marked myopathic changes at the motor end-plate region. With continued injections, however, some recovery of the structural features did occur suggesting the reconstructive changes in the affected regions.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D006614:Hindlimb; D006651:Histocytochemistry; D009045:Motor Endplate / Q000187:drug effects* / Q000648:ultrastructure; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D009133:Muscular Atrophy / Q000139:chemically induced; D009243:NAD / Q000378:metabolism; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats
chemical_list: D009243:NAD; D009388:Neostigmine; D000251:Adenosine Triphosphatases