Oncogenic transformation of human embryo lung cells by human cytomegalovirus.
Persistent infection of human embryo lung fibroblasts with a genital isolate of cytomegalovirus resulted in oncogenic transformation of these cells. Immunofluorescence techniques detected virus-specific antigens, while microcytotoxicity tests established that the transformed cells share a membrane antigen with hamster cells transformed by inactivated cytomegalovirus. The transformed human cells induced progressively growing tumors in weanling athymic nude mice.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D051379:Mice; D008819:Mice, Nude
D000956:Antigens, Viral