Insulomas and multiple endocrine neoplasia.
Seventy-eight patients with insuloma diagnosed between 1959 and 1968 in Sweden were studied for neoplasia in other organs. Twenty-one patients had beta-cell islet tumors, 14 Zollinger-Ellison's syndrome and non-beta-cell islet tumors, while no endocrine activity was demonstrated in 43 patients. Of the last-mentioned group, 9 patients had co-existing disease of other endocrine organs. In 10 patients, non-endocrine organs were found to be affected by malignant diseases. It appears probable that the tissue of the pancreatic islets, like parathyroid tissue, can react with hyperplasia with a later development of adenoma, secondary to tumors in other organs.
D007516:Adenoma, Islet Cell / Q000150:complications*; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000150:complications; D002528:Cerebellar Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010190:Pancreatic Neoplasms / Q000150:complications*; D013964:Thyroid Neoplasms / Q000150:complications; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis