title: [Cardiac anti-arrhythmic effect of various N-substituted piperazine derivatives with respect to aconitine in the rat].
abstract: Anti-arrhythmic activity of some piperazine derivatives has been investigated upon cardiac arrythmia induced by aconitine in albinos rat. Among mono-substituted derivatives trimetazidine is active. Among di-substituted derivatives cinepazide and hydroxyzine are active but medibazine have a doubtful activity and piribedil and cinnarizine are devoid of activity.
mesh_terms: D000157:Aconitine / Q000037:antagonists & inhibitors*; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006919:Hydroxyzine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D014292:Trimetazidine / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D010879:Piperazines; D006919:Hydroxyzine; D014292:Trimetazidine; D000157:Aconitine
vernacular_title: Action anti-arythmique cardiaque de quelques dérivés pipérazinés N-substitués vis-à-vis de l'aconitine, chez le rat.