[Effect of aldosterone and ACTH administration on fluctuation of 5-HT content of the brain and pentobarbital anesthesia in adrenalectomized rats].
The present study was undertaken to determine whether or not adrenalectomy influences anesthesia and increase in brain 5-HT induced by pentobarbital and if such is the case, whether or not aldosterone or ACTH inhibit the effect of adrenalectomy. Male Wistar rats were adrenalectomized or sham-operated and injected with aldosterone (20mug5hg i.p.), ACTH (5.0 mg/kg i.p.) or the vehicle (1.0 ml/kg i.p.) everyday for 1 week after a postoperative interval of 3 days. These rats ware given a normal diet and 1% saline approximately 5% glucose solution. Animals were injected with pentobatbital (50 mg/kg i.p.) 18 hr after the last injection of each hormone. It was found that adrenalectomy enhanced "pentobarbital-anesthesia", although there was no such effect in the adrenalectomized rats pretreated with each hormone. Adrenalectomy inhibited an increase of 5-HT in the brain after pentobarbital, but the hormone pretreatment to those rats did not antagonize the inhibition of the 5-HT increase.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000450:Aldosterone / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry; D008297:Male; D010424:Pentobarbital / Q000037:antagonists & inhibitors*; D051381:Rats; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D010424:Pentobarbital