Mouse mammary tumor virus as a model for viral carcinogenesis.
Evidence is presented suggesting that genetic control may be the limiting factor in mammary tumor virus (MTV) positive mammary oncogenesis. Studies with hybrid mice involving high and low MTV-expressing murine strains suggest that expression of MTV in milk may not be as important in tumorigenesis as previously thought. The usefulness of the murine MTV model in the study of mammary malignancy is discussed.
D000818:Animals; D005260:Female; D006728:Hormones / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000503:physiopathology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D008954:Models, Biological
D006728:Hormones