title: [A new beta-blocking agent in the treatment of chronic open-angle glaucoma: timolol maleate. Effect of instillation of 1 drop on the intraocular pressure].
abstract: A total of 45 patients with chronic open-angle glaucoma were divided randomly into three groups of fifteen. Each patient in each group was given one drop into one eye (the other eye serving as a control), of either placebo, timolol 0,5%, or timolol 1,5%. The patients were observed for a period of seven hours, and results showed that timolol was effective in reducing ocular tension when compared to placebo. It was also rapid in action (one to two hours after instillation), and no side-effects were noted. Timolol 0,5% appears to be as equally effective as the 1,5% strength.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D013999:Timolol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D011412:Propanolamines; D013999:Timolol
vernacular_title: Un nouveau béta-bloquant dans le traitement du glaucome chronique à angle ouvert: le maléate de timolol. Effet tensionnel de l'instillation d'une goutte.