Timed-release depot for anticancer agents.
The timed-release of anticancer agents from composities with poly (lactic acid) was studied in rats. In the case of cyclophosphamide-poly (lactic acid) composites, 67% of the administered dose was released within 34 days. With cis-dichlorodiammineplatinum (II), the amount of drug released was only 9.3% within the same period. This difference might be attributed to the different solubilities of these two drugs in the polymer. Electron spectroscopy chemical analysis, a new tool, was used to investigate the extent of diffusion of drugs in polymer films.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004578:Electron Spin Resonance Spectroscopy; D007773:Lactates; D008297:Male; D009584:Nitrogen / Q000652:urine; D010758:Phosphorus / Q000652:urine; D010984:Platinum / Q000652:urine; D011108:Polymers; D051381:Rats; D013997:Time Factors
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D007773:Lactates; D011108:Polymers; D010758:Phosphorus; D010984:Platinum; D003520:Cyclophosphamide; D009584:Nitrogen; D002945:Cisplatin