Malignant transformation of hamster kidney cells by BK virus.
Primary hamster kidney cells were transformed by BK virus, a new human papovavirus. Transformed (HKBK) cell produced BK virus T antigen and induced tumors in hamsters that developed antibodies to BK virus T antigen. BK virus was rescued from HKBK cells by Sendai virus-assisted fusion with permissive cells. One out of six cell lines derived from HKBK cell-induced tumors showed the same characteristics as HKBK cells.
D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification; D000951:Antigens, Neoplasm / Q000302:isolation & purification; D000956:Antigens, Viral / Q000302:isolation & purification; D002459:Cell Fusion; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D046508:Culture Techniques; D005347:Fibroblasts; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D006801:Humans; D007668:Kidney; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D010222:Parainfluenza Virus 1, Human / Q000254:growth & development; D011120:Polyomavirus / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification
D000914:Antibodies, Viral; D000951:Antigens, Neoplasm; D000956:Antigens, Viral