Accumulation of cAMP and positive inotropic effect evoked by isoproterenol under the graded inhibition of phosphodiesterase by papaverine in the isolated rabbit papillary muscle.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010208:Papaverine / Q000494:pharmacology; D011817:Rabbits; D013268:Stimulation, Chemical
D010208:Papaverine; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007545:Isoproterenol