Hormonal induction of glutamate dehydrogenase in rat liver.
Glutamate dehydrogenase rapidly increases in microsomes and appears in the cytoplasm after administration of cortisone, cAMP, hydrocortisone-acetate. Prolonged administration of ACTH maintains high level of enzyme in the mitochondria and microsomes. Hydrocortisone-acetate, insulin and cortisone decrease drastically enzyme in mitochondria.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D003348:Cortisone / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D006889:Hydroxycorticosteroids / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D013997:Time Factors
D006889:Hydroxycorticosteroids; D007328:Insulin; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D005969:Glutamate Dehydrogenase; D003348:Cortisone; D003345:Corticosterone; D006854:Hydrocortisone