title: The effect of germfree and SPF maintenance conditions on the lifespan and diseases of small laboratory animals.
abstract: The mortality rates and spontaneous diseases defining the course of natural mortality graphs in colonies of Han: NMRI mice kept under conventional, SPF and germfree maintenance conditions are reported. A specific problem in SPF colonies is caused by ubiquitous germs. The lesions and possible reasons for such types of infections are discussed.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D005856:Germ-Free Life; D005921:Glomerulonephritis / Q000662:veterinary; D007938:Leukemia / Q000662:veterinary; D008017:Life Expectancy; D008321:Mammary Glands, Animal; D051379:Mice; D009026:Mortality; D009369:Neoplasms / Q000662:veterinary; D051381:Rats; D013047:Specific Pathogen-Free Organisms; D013223:Statistics as Topic