Inhibited growth in vivo of a mouse pregnancy-dependent mammary tumor (TPDMT-4) by an antiestrogen, 2alpha, 3alpha-epithio-5alpha-androstan-17beta-ol (10275-S).
TPDMT-4 mammary tumors, characterized by growth during pregnancy and postpartum regression, grew continuously in DDD virgin mice carrying pituitary isografts or 17 beta-estradiol plus progesterone pellets. In the experimental models, effects of 2alpha,3alpha-epithio-5alpha-androstan-17beta-ol(10275-S), testosterone, and ovariectomy were investigated. When tumors implanted with pituitary isografts into the fat pad reached palpable volumes, animals were ovariectomized or received 5 s.c. injections of 100 mug to 1 mg 10275-S or 300 mug testosterone weekly. Tumors regressed immediately after ovariectomy or after the start of 10275-S treatment and after approximately the 10th day of testosterone treatment. Cystadenomatous morphology with strong secretory activity was noticed in treated animals. Tumor growth induced by 17beta-estradiol plus progesterone pellets was inhibited completely or partially by 3 s.c. injections of 50 to 500 mug 10275-S or 100 mug testosterone weekly starting from the day after tumor and 17beta-estradiol plus progesterone pellet implantation.
D000731:Androstanes / Q000494:pharmacology*; D000732:Androstanols; D000818:Animals; D002369:Castration; D002460:Cell Line; D004958:Estradiol / Q000378:metabolism; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010902:Pituitary Gland / Q000637:transplantation; D011247:Pregnancy; D011248:Pregnancy Complications; D011374:Progesterone / Q000378:metabolism; D011956:Receptors, Cell Surface; D013739:Testosterone / Q000494:pharmacology; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D000731:Androstanes; D000732:Androstanols; D011956:Receptors, Cell Surface; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; C002976:epitiostanol