[Immunocytological studies of C cells with anti-calcitonin or antisomatostatin immunoserums in rats treated with vitamin D, thyroxine or benzyl-thiouracil].
In rats treated with vitamin D3, thyroxin or BTU alone or with associations of vitamin D3 + BTU or vitamin D + thyroxin, immunocytochemical studies with an anti-human calcitonin serum show a stimulating effect of vitamin D and of thyroxin and an inhibiting effect of BTU on the C cells of the thyroïd. These results are in agreement with the existence of functional relations between follicular and C cells. A few calcitonin-containing cells are immunoreactive to an anti-somatostatin serum. All the C cells contain both calcitonin and somatostatin when they are grouped in a single big interfollicular cluster.
D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013889:Thiouracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*; D014807:Vitamin D / Q000494:pharmacology*
D007106:Immune Sera; D014807:Vitamin D; D013004:Somatostatin; D013889:Thiouracil; D002116:Calcitonin; D013974:Thyroxine
Etude cyto-immunologique des cellules C avec des immunsérums anti-calcitonine ou anti-somatostatine chez des rats traités par la vitamine D, la thyroxine ou le benzyl-thiouracile.