title: Malignant fibrous histiocytoma.
abstract: Two patients are presented who had malignant fibrous histiocytomas of the skin and soft tissue. These tumors characteristically consist of a solitary mass, 0.5 cm to 12.0 cm, which has skin fixation, is circumscribed and firm. Microscopically, there is a pattern of histiocytes and bizarre histiocytic giant cells intermingled in a fibrous stroma with fibroblasts arranged in a whirling pattern. The lesion is treated with wide excision and skin grafting. Local recurrence is common. Metastasis is less common, but with metastasis the prognosis is poor.
mesh_terms: D000328:Adult; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000628:therapy