Cyclic adenosine 3':5'-monophosphate and inhibition of deoxyribonucleic acid synthesis in vitro.
Results are presented which suggest that inhibition of tritiated thymidine incorporation into the deoxyribonucleic acid of bone marrow in vitro by high concentrations of cyclic adenosine 3':5'-monophosphate is pharmacological in nature, and thus apparently unrelated to the physiological actions of cAMP.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D001854:Bone Marrow Cells; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D003841:Deoxycytidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D003841:Deoxycytidine; D014316:Tritium; D000249:Adenosine Monophosphate; D003994:Bucladesine; D004247:DNA; D013806:Theophylline; D000242:Cyclic AMP; D006152:Cyclic GMP; D013936:Thymidine