Effect of cyproheptadine on the spontaneous diurnal variations of plasma ACTH-cortisol and ACTH-GH secretion induced by l-dopa.
Cyproheptadine administration resulted in marked reduction and complete inhibition of the GH and ACTH-cortisol responses to L-dopa in a group of healthy subjects. If this drug acts by antagonizing serotonin, as assumed, this study suggests that serotonin is also involved in L-dopa induced GH and ACTH release.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002940:Circadian Rhythm / Q000187:drug effects; D003533:Cyproheptadine / Q000494:pharmacology*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D012701:Serotonin / Q000502:physiology
D003533:Cyproheptadine; D012701:Serotonin; D007980:Levodopa; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone