[Information obtained by liver biopsy in 100 tuberculous patients].
The results of liver biopsy in 100 patients with tuberculosis are reported. In 8 patients, biopsy only occurred secondarily, during liver disease which appeared during antituberculous treatment. In five cases, the association of rifamycin and isoniazid was probably responsible and the mild histological signs noted suggested a favourable course after stopping one of the drugs or simply reducing the dose. The 3 other patients had virus hepatitis and biopsy was of prognostic interest by revealing the onset of post-hepatic cirrhosis. In 92 cases, liver biopsy was carried out before treatment. In 34 cases the liver was normal, in 38 patients there were hisotlogical changes which did not suggest tuberculosis but, probably, alcoholism. These were : steatosis, in 21 cases, cirrhosis in 8 cases, a mixture of steatosis and cirrhosis in 4 cases, and acute alcoholic hepatitis in 5 cases. Finally, in 20 cases, biopsy revealed an appearance of granulomatous hepatitis. Although this lesion is significant in the development of the disease, it is not characteristic of tuberculosis unless there is caseous necrosis, as in 2 cases, and unless culture of the biopsy material is positive, as in one case out of 9, i.e. the diagnostic interest of liver biopsy is not very great compared with prognostic interest. By determining the anatomical condition of the liver, often not obvious when simple liver function tests are carried out, it permits one to forsee to some extent the tolerance of the liver to antituberculous treatment, especially in alcoholics.
D000437:Alcoholism / Q000150:complications; D001706:Biopsy / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis; D005234:Fatty Liver / Q000175:diagnosis; D006501:Hepatic Encephalopathy / Q000209:etiology; D006505:Hepatitis / Q000175:diagnosis; D006506:Hepatitis A / Q000175:diagnosis; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects; D008099:Liver / Q000187:drug effects; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D012293:Rifampin / Q000009:adverse effects; D014376:Tuberculosis / Q000150:complications*; D014386:Tuberculosis, Hepatic / Q000175:diagnosis / Q000473:pathology
D007538:Isoniazid; D012293:Rifampin
Renseignements fournis par la biopsie hépatique chez 100 malades tuberculeux