Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats.
Two hundred twenty-six specific pathogenfree male and female F344 rats were exposed to nickel sulfide inhalations for 78 weeks (5 days/wk, 6 hr/day) and observed for an adiditional 30-week period. For the same amount of time, 214 rats were exposed to filtered room air and served as controls. Rats exposed to nickel sulfide showed a significantly higher incidence of pulmonary hyperplastic and neoplastic lesions originating from the bronchial and bronchiloo-alveloar segments. The overall incidence of lung tumors in the animals treated with nickel sulfide was 14 percent compared with 1 percent in the controls. Pulmonary inflammatory reactions were also greatly increased. Injection of an agent (hexachlorotetra-fluorobutane) that induced lung infarction did not increase the proportion of animals having lesions, nor did it alter the type of lesions found in animals exposed to nickel sulfide.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002073:Butanes; D002273:Carcinogens; D004781:Environmental Exposure; D005260:Female; D005856:Germ-Free Life; D006801:Humans; D006845:Hydrocarbons, Fluorinated; D006965:Hyperplasia / Q000473:pathology; D007238:Infarction / Q000139:chemically induced / Q000150:complications; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009532:Nickel / Q000633:toxicity*; D011014:Pneumonia / Q000139:chemically induced; D011652:Pulmonary Circulation; D051381:Rats; D012190:Retroviridae / Q000302:isolation & purification*; D013997:Time Factors
D002073:Butanes; D002273:Carcinogens; D006845:Hydrocarbons, Fluorinated; D009532:Nickel