title: Physiological and toxicological aspects of smoke produced during the combustion of polymeric materials.
abstract: Normally one expects that flame contact is the major cause of injury and death during fires. Analysis of the factors involved in numerous fires has revealed that most deaths were not due to flame contact, but were a consequence of the production of carbon monoxide, nitrogen oxides, and other combustion products, such as aldehydes, low molecular weight alcohols, hydrogen cyanide, and other noxious species. The major emphasis within the scope of this paper relates to the physiological and toxicological aspects of smoke produced during the combustion of materials. Special emphasis is directed toward laboratory procedures which have been developed to determine the qualitative and quantitative analysis of smoke, factors pertaining to smoke development, and to measure the response of laboratory animals exposed to smoke. The effects that fire retardants, incorporated into polymeric materials as a means of improving flammability characteristics, may have on smoke development, the mechanism of polymer degradation, and on the survival response of laboratory animals are also considered.
mesh_terms: D000447:Aldehydes / Q000633:toxicity; D000818:Animals; D002059:Burns, Inhalation / Q000209:etiology; D002249:Carbon Monoxide Poisoning / Q000150:complications / Q000473:pathology; D002263:Carboxyhemoglobin / Q000096:biosynthesis; D004781:Environmental Exposure; D004924:Escape Reaction; D005390:Fires / Q000517:prevention & control; D006801:Humans; D006838:Hydrocarbons / Q000633:toxicity; D006851:Hydrochloric Acid / Q000506:poisoning; D006856:Hydrogen Cyanide / Q000506:poisoning; D000860:Hypoxia; D011041:Poisoning / Q000209:etiology; D011108:Polymers; D011140:Polyurethanes / Q000032:analysis; D011901:Ranvier's Nodes / Q000473:pathology; D012583:Schwann Cells / Q000473:pathology; D012906:Smoke / Q000032:analysis; D013458:Sulfur Dioxide / Q000633:toxicity; D013534:Survival; D014116:Toxicology
chemical_list: D000447:Aldehydes; D006838:Hydrocarbons; D011108:Polymers; D011140:Polyurethanes; D012906:Smoke; D013458:Sulfur Dioxide; D006856:Hydrogen Cyanide; D002263:Carboxyhemoglobin; D006851:Hydrochloric Acid