Isolation of a metabolite capable of differentially supporting the growth of nicotinamide adenine dinucleotide auxotrophs of Escherichia coli.
A compound, isolated from the culture fluid of a nadC auxotroph of Escherichia coli grown in a minimal medium, supports the growth of both a nadA and a nadB mutant. This metabolite exhibits an ultraviolet light absorption spectrum and a mass spectrum, different from quinolinic acid. This compound may be the precursor of quinolinic acid, an intermediate in the biosynthesis of nicotinamide adenosine dinucleotide.
D001224:Aspartic Acid / Q000378:metabolism; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D009154:Mutation; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000096:biosynthesis; D009539:Nicotinic Acids / Q000096:biosynthesis; D011805:Quinolinic Acids
D009539:Nicotinic Acids; D011805:Quinolinic Acids; D009243:NAD; D009536:Niacinamide; D001224:Aspartic Acid