Endocrinological findings in sterile pink-eyed mice.
Mice homozygous for  rho-25h, a mutation at the pink-eye locus, are small, nervous and male sterile, with abnormal sperm morphology: females have very low fecundity. Evidence is presented that in both sexes the pars nervosa of the rho-25h/rho-25h pituitary contains degenerating nerve axons, that the hypothalamus has a reduced binding capacity for oestradiol-17 beta and that thyroid iodine binding is reduced. No changes were observed in the anterior pituitary. In rho-25h/rho-25h females, the uterus is threas-like and unresponsive to oestradiol, and the ovaries are small with many abnormal follicles. Possible modes of action of the rho locus are duscussed with reference to this and pre-existing data on the rho phenotype.
D000818:Animals; D001665:Binding Sites; D004700:Endocrine System Diseases / Q000235:genetics*; D004958:Estradiol / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005298:Fertility; D006720:Homozygote; D007031:Hypothalamus / Q000378:metabolism; D007248:Infertility, Male / Q000235:genetics*; D007274:Injections, Intraperitoneal; D007455:Iodine / Q000378:metabolism; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009154:Mutation; D010053:Ovary / Q000473:pathology; D010902:Pituitary Gland / Q000473:pathology; D011956:Receptors, Cell Surface; D013094:Spermatozoa / Q000473:pathology; D013961:Thyroid Gland / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000503:physiopathology
D011956:Receptors, Cell Surface; D004958:Estradiol; D007455:Iodine