title: Organ culture of human nervous system tumors.
abstract: Tumors of the human nervous system (neuroblastomas, an ependymoma, a medulloblastoma, and a Schwannoma) obtained during surgery have been cultured organotypically by the method of Wolff. The tumors retained characteristic morphology, organization and patterns of behavior in vitro, and one neuroblastoma gave rise to a growing long-term culture. Long-term organotypic culture, where maintenance of tissue organization and growth occur together, is recommended for the study of neoplasms of the nervous system.
mesh_terms: D002454:Cell Differentiation; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004806:Ependymoma / Q000473:pathology; D008527:Medulloblastoma / Q000473:pathology; D008938:Mitosis; D009380:Neoplasms, Nerve Tissue; D009442:Neurilemmoma / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D009924:Organ Culture Techniques