title: The control of bluetongue in an enzootic situation.
abstract: On account of the wide host range of bluetongue virus and its biological transmission by insects, control of the disease in an enzootic situation is based primarily on the active immunisation of susceptible animals as well as on the prevention of contact between the insect vectors and the susceptible hosts. In spite of their unquestionable value, the egg attenuated vaccines which are currently employed for prophylactic immunisation, have certain shortcomings. The existence of 16 known serotypes of bluetongue virus makes it difficult to achieve a very wide spectrum of immunity in sheep vaccinated once or twice only. The problems which are experienced with the immunisation of lambs born in spring are indicated. The present vaccine can also present problems when used in breeding animals. Furthermore, the costs involved in the annual vaccination of large numbers of animals are considerable. The need for a vaccine for cattle is indicated. Work is also being conducted at present on the development of an inactivated vaccine for use in sheep. The use of novel virological techniques may aid in the future development of absolutely safe and highly efficient vaccines against bluetongue.
mesh_terms: D000818:Animals; D001819:Bluetongue / Q000517:prevention & control* / Q000635:transmission; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control; D002519:Ceratopogonidae; D004197:Disease Reservoirs; D005260:Female; D007303:Insect Vectors; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary; D012756:Sheep; D013019:South Africa; D014611:Vaccination; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines