[Cytochrom P-450. Its value in toxicology. I. Physicochemical and biochemical properties].
We present the distribution of cytochrome P450, the terminal oxidase of the microsomal drug-metabolizing system among the different species, organs, and its subcellular localization. Physicochemical properties, and more specially spectral properties, of this hemoprotein are reviewed. We also described the two microsomal electron transport chains and the hypothetical cyclic oxidoreduction mechanism of cytochrome P450 in the hydroxylation reactions.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000494:pharmacology*; D003579:Cytochrome Reductases; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport; D005288:Ferredoxins / Q000378:metabolism; D006420:Hemeproteins; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D011487:Protein Conformation; D011489:Protein Denaturation; D013054:Spectrophotometry, Atomic; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism
D005288:Ferredoxins; D006420:Hemeproteins; D013481:Superoxides; D003577:Cytochrome P-450 Enzyme System; D003579:Cytochrome Reductases
Le cytochrome P450. Son intérêt en toxicologie. I. - Propriétés physicochimiques et biochimiques