title: [Regression of left ventricular hypertophy in the ECG during antihypertensive treatment: preliminary observations (author's transl)].
abstract: Typical signs of left ventricular hypertrophy (LVH) were present in the ECG of 36 (10 women, 26 men) of 127 persons with essential hypertension (46 women, 81 men). After a two-year course of combined drug treatment (chlortalidone, reserpine, methyl-dopa, hydralazine) with effective blood-pressure reduction LVH was still present in the ECG of 29, after a four-year course of only 15 among 36, i. e. a reduction in the presence of LVH of nearly 60%. Since the patients' body-weight remained unchanged during this period, the regression in ECG changes is ascribed to the effectiveness of the drug treatment.
mesh_terms: D000328:Adult; D000368:Aged; D006332:Cardiomegaly / Q000175:diagnosis* / Q000209:etiology; D002752:Chlorthalidone / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D008875:Middle Aged; D012110:Reserpine / Q000627:therapeutic use
chemical_list: D006830:Hydralazine; D008750:Methyldopa; D012110:Reserpine; D002752:Chlorthalidone
vernacular_title: Rückbildung der linksventridulären Hypertrophie im Elektrokardiogramm während antihypertensiver Behandlung. Vierjährige Verlaufsbeobachtung.