Phosphorylation of DNA polymerase.
Both E. coli and calf thymus DNA polymerase can be phosphorylated by cAMP-dependent protein kinase and phosphorylation appears to stimulate the DNA polymerase reaction. Conversely, dephosphorylation of the polymerase molecule, by a protein phosphatase, inhibits the polymerase reaction.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D001667:Binding, Competitive; D000242:Cyclic AMP / Q000494:pharmacology; D004254:DNA Nucleotidyltransferases / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D013268:Stimulation, Chemical
D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D011494:Protein Kinases; D004254:DNA Nucleotidyltransferases; D010744:Phosphoric Monoester Hydrolases