[Changes in the noradrenaline level and synthesis of nuclear RNA in the brain of rats with disturbances of the emotions and conditioned-defense behavior].
Brain noradrenaline (Na) exhaustion in reserpine-, disulfiram-or diethyldithio carbamate-treated rats was followed by a fall of the nRNA synthesis, emotional and conditioned behaviour disturbances. In accumulation of cerebral NA (ipraside and imipramine injections) there is an increase in the rate of synthesis, of the nuclear RNA. Prevention of the exhausting effect of reserpine by a preliminary injection of ipraside also prevented disturbances of the nuclear RNA synthesis.
D000342:Affective Symptoms / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D003214:Conditioning, Classical; D004221:Disulfiram / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D006801:Humans; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D012313:RNA; D012110:Reserpine; D004050:Ditiocarb; D007490:Iproniazid; D004221:Disulfiram; D009638:Norepinephrine
Izmeneniia soderzhaniia noradrenalina i sintez iadernoĭ RNK v golovnom mozge krys pri narushenii émotsional'nogo i uslovno-oboronitel'nogo povedeniia