[Effect of triftazin on the transmission of excitation in the brain of the rabbit under the prolonged administration of the preparation].
Experiments were conducted on awake rabbits to which trifluoperazine was given daily for 2 weeks in a dose of 1 mg/kg a day; a study was made of the reaction of the cortical neurones in response to the electrostimulation of its adjacent areas. In measuring the dispersions of the poststimular histograms it was found that under the effect of trifluoperazine there occurred a reduction of the value and the duration of the responses of the cortical neurons after the infliction of stimulation. The effect obtained after the administration of trifluoperazine was regarded from the point of view of aggravation of the signal conduction in the neuronal reticula.
D000639:Amitriptyline / Q000008:administration & dosage; D000818:Animals; D001921:Brain / Q000187:drug effects*; D004558:Electric Stimulation; D004594:Electrophysiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014268:Trifluoperazine / Q000494:pharmacology*; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
D000639:Amitriptyline; D014268:Trifluoperazine
Vliianie triftazina na peredachu vozbuzhdeniia v golovnom mozge krolika pri dlitel'nom vvedenii preparata