Alterations of mitochondrial properties in folate nephropathy.
Folate nephropathy was selected as a model to study renal mitochondrial response after tubular injury. 20 h after injection, 14C-leucine incorporation was suppressed to 20--30% of control, 14C-mannose incorporation was 63--78% greater than control while the activities of succinic dehydrogenase and monoamine oxidase were unaltered. By 40 h, 14C-leucine incorporation had been restored to control values. Also, at 20 h, ATPase activity sensitive to oligomycin inhibition had increased by 45--73%, whereas K+-stimulated ATPase activity was reduced in the experimental mitochondrial fractions. The results are discussed along with other studies of mitochondria in experimental renal disease.
D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D005492:Folic Acid / Q000009:adverse effects* / Q000494:pharmacology; D006023:Glycoproteins / Q000096:biosynthesis; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008995:Monoamine Oxidase / Q000032:analysis; D014176:Protein Biosynthesis; D051381:Rats; D013385:Succinate Dehydrogenase / Q000032:analysis
D006023:Glycoproteins; D005492:Folic Acid; D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase; D000251:Adenosine Triphosphatases