Mastocytoma cell migration in vitro: inhibition by MIF-containing supernatants.
Supernatants with macrophage migration inhibition factor (MIF) activity were obtained from cultures of antigen-stimulated guinea pig and human lymphocytes, and from SV40-infected monkey kidney cells. The monkey and human but not guinea pig preparations were effective in inhibiting migration of mastocytoma cells as well as macrophages. This inhibition of migration was not associated with cytotoxicity and was reversible.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002464:Cell Migration Inhibition; D002465:Cell Movement; D002474:Cell-Free System; D002478:Cells, Cultured; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors; D008264:Macrophages / Q000276:immunology; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D013539:Simian virus 40
D008263:Macrophage Migration-Inhibitory Factors