title: Pentose shunt, phosphoribosylpyrophosphate generation and purine-phosphoribosyltransferases in erythrocytes of patients with polycythemia vera.
abstract: Erythrocytes of patients with polycythemia vera exhibited increased activity of oxidative pentose shunt, accelerated generation of phosphoribosylpyrophosphate, increased incorporation of 14C-adenine into nucleotides, and increased activity and thermostability of adenine-phosphoribosyltransferase.  These abnormalities are attributed to age dependency of the pathways concerned and presence in polycythemia vera of an erythrocyte population younger than normal.
mesh_terms: D000225:Adenine / Q000097:blood; D000228:Adenine Phosphoribosyltransferase / Q000097:blood; D000375:Aging; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000097:blood; D008297:Male; D009711:Nucleotides / Q000097:blood; D010428:Pentosephosphates / Q000097:blood*; D010429:Pentoses / Q000097:blood*; D010430:Pentosyltransferases / Q000097:blood*; D010754:Phosphoribosyl Pyrophosphate / Q000096:biosynthesis / Q000097:blood*; D011087:Polycythemia Vera / Q000097:blood* / Q000201:enzymology; D012268:Ribose-Phosphate Pyrophosphokinase / Q000097:blood
chemical_list: D009711:Nucleotides; D010428:Pentosephosphates; D010429:Pentoses; D010754:Phosphoribosyl Pyrophosphate; D010430:Pentosyltransferases; D000228:Adenine Phosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase; D012268:Ribose-Phosphate Pyrophosphokinase; D000225:Adenine