Experimental infection of calves with respiratory syncytial virus.
Three bovine isolates and one human isolate of RS virus were given intranasally to gnotobiotic, colostrum-deprived and conventional calves. All isolates produced a biphasic pyrexia associated with a serous nasal discharge. Virus was recovered from nasal secretions 4-10 days after inoculation from nasal, tracheal and bronchial mucosae and lung of animals killed 7-13 days after inoculation. Infection did not produce any macroscopic lesions, but histologically there was a focal degenerative rhinitis and a catarrhal bronchiolitis with the occasional formation of syncytia in bronchioles and alveoli.
D000281:Administration, Intranasal; D000818:Animals; D001980:Bronchi / Q000473:pathology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000473:pathology; D002478:Cells, Cultured; D003126:Colostrum / Q000276:immunology; D005856:Germ-Free Life; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012136:Respiratory Syncytial Viruses / Q000276:immunology / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D013737:Testis