Alpha1-antitrypsin deficiency and hepatic carcinoma.
A patient with homozygous ZZ alpha1-antitrypsin deficiency and severe pulmonary emphysema was discovered to have a mixed hepatocellular and cholangiolar hepatic carcinoma arising in a noncirrhotic liver. Because of the increasing frequency of hepatomas in patients with alpha1-antitrypsin deficiency, it is suggested that a causal relationship may exist.
D002759:Adenoma, Bile Duct / Q000150:complications* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology; D006720:Homozygote; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000150:complications*; D019896:alpha 1-Antitrypsin Deficiency