Hamster ependymomas produced by intracerebral inoculation of a human papovavirus (MMV).
Ependymomas were produced in 3 of 11 newborn hamsters inoculated intracerebrally with a human papovavirus (MMV) isolated from a malignant lymphoma of the brain of a child with Wiskott-Aldrich syndrome. One of the tumors was serially transplanted into weanling hamsters. Cells from the transplanted tumors and from cell cultures derived from these tumors contained an intranuclear "T" antigen that reacted with simian virus 40 T antibody.
D000818:Animals; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D001932:Brain Neoplasms / Q000209:etiology* / Q000276:immunology; D006224:Cricetinae; D016403:Lymphoma, Large B-Cell, Diffuse / Q000382:microbiology; D009374:Neoplasms, Experimental / Q000209:etiology; D027383:Papillomaviridae; D027382:Polyomaviridae; D013539:Simian virus 40 / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral