[Antiviral thiosemicarbazone and related compounds. III. Quantitative relationships between structure and antiviral activity of isantin-beta-isothio-semicarbazone against mengo virus].
The virostatic activity of isatin-beta-isothiosemicarbazones can be described quantitatively by hydrophobic, electronic, and steric substituent constants using multivariate regression analysis. A preceding Free-Wilson analysis allows data smoothening, and thus improved adaptation. Predictions made on the basis of the quantitative structure-action relationships obtained could be confirmed experimentally by synthesizing and testing the corresponding compounds.
D000998:Antiviral Agents; D007211:Indoles / Q000494:pharmacology*; D007510:Isatin / Q000494:pharmacology*; D008574:Mengovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000494:pharmacology*; D014779:Virus Replication
D000998:Antiviral Agents; D007211:Indoles; D013882:Thiosemicarbazones; D007510:Isatin
Antivirale Thiosemikarbazone und verwandte Verbindungen III. Quantitative Beziehungen zwischen Struktur und antiviraler Aktivatät von Isatin-beta-isothiosemikarbazonen gegen Mengovirus