Spontaneous variations in the cell population of a T-cell lymphoma during tissue culture and transplantation.
Immunologically induced T-cell lymphomas were kept for long period fo time in isotransplantation and in tissue culture. Initially, a certain number of cells within the tumor showed differentiation towards histiocytes. These disappeared completely after about the twentieth graft generation when the tumor changed toward a more atypical and more uniform neoplasm. That change was correlated with a decrease in transplantability, a limited growth in tissue culture, and a decrease in density of theta antigens on tumor cell membranes. While the original tumor and early grafts contained occasional C-type particles, these were never demonstrated in late tumor grafts. The possible implications of these changes are discussed.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D006644:Histiocytes / Q000166:cytology; D007181:Inclusion Bodies, Viral; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012190:Retroviridae; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000648:ultrastructure; D014181:Transplantation Immunology; D014185:Transplantation, Isogeneic
D011947:Receptors, Antigen, B-Cell