Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU.
The application of BCNU, CCNU and MeCCNU has been shown to greatly reduce the number of tumors induced in rats by transplacentally administered ENU and to inhibit the full development of tumor proliferation. Moreover, no neurinomas appeared after treatment with CCNU. The application of GCNU proved to be much less effective. Our statistics in the form of tables showing these findings are included and discussed.
D000477:Alkylating Agents / Q000627:therapeutic use*; D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005038:Ethylnitrosourea; D005260:Female; D005315:Fetal Diseases; D005910:Glioma / Q000473:pathology / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D009380:Neoplasms, Nerve Tissue / Q000139:chemically induced / Q000517:prevention & control*; D009442:Neurilemmoma / Q000517:prevention & control; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D009837:Oligodendroglioma / Q000473:pathology / Q000517:prevention & control; D011247:Pregnancy; D051381:Rats
D000477:Alkylating Agents; D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea