[Effect of substances inhibiting the ion transport on Mg2+, Ca2+-ATPase activity of synaptic plasma membranes].
The Mg2+, Ca2+-ATPase activity of plasma membranes in bull brain synaptosomas was studied as affected by ruthenium red, hexamine cobalt, aminazine, verapamyl, melipramin, lanthanum acetate and oligomycin. Lanthanum acetate in a concentration of 5.10(-5)M is shown to inhibit completely the enzyme activity. Ruthenium red and hexamine cobalt in a concentration of 10(-4) inhibit this ATPase activity by 50-60%. Melipramin, aminazine, verapamyl in concentrations of 10(-6)-10(-4)M and oligomycin in a concentration of 0.01-5 microgram/ml have no effect on the enzyme activity.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000201:enzymology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002417:Cattle; D002746:Chlorpromazine / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008709:Methenamine / Q000494:pharmacology; D009840:Oligomycins / Q000494:pharmacology; D012430:Ruthenium Red / Q000494:pharmacology; D013570:Synaptic Membranes / Q000187:drug effects / Q000201:enzymology*; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology; D014700:Verapamil / Q000494:pharmacology
D009840:Oligomycins; D012430:Ruthenium Red; D003035:Cobalt; D014700:Verapamil; D000252:Calcium-Transporting ATPases; D008274:Magnesium; D008709:Methenamine; D007099:Imipramine; D002746:Chlorpromazine
Vliianie veshchestv, ugnetaiushchikh transport ionov, na Mg2+, Ca2+-ATP-aznuku aktivnost' plezmaticheskikh membran sinaptosom.