Long-term steroid therapy in patients with adrenogenital syndrome.
Fifteen years' experience with the adrenogenital syndrome at Duke University Medical Center is reviewed. Twenty-six patients were diagnosed before age 2. Of these, 20 had the salt-losing syndrome. The complications encountered and the results obtained in terms of growth, developemnt, and fertility are discussed. Delay in diagnosis and inappropriate gender assignment continue to be a problem.
D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D000365:Age Determination by Skeleton; D000367:Age Factors; D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003348:Cortisone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D003907:Dexamethasone; D005260:Female; D005298:Fertility / Q000187:drug effects; D005836:Genitalia, Female / Q000254:growth & development; D006801:Humans; D007621:Karyotyping; D008297:Male; D008572:Menarche / Q000187:drug effects; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D011279:Pregnanetriol / Q000652:urine; D012640:Seizures / Q000209:etiology; D012732:Sex Determination Analysis; D013997:Time Factors
D015068:17-Ketosteroids; D011279:Pregnanetriol; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D003348:Cortisone; D008775:Methylprednisolone