Ultrastructures of glosso-palatal fusion after treatment of meclozine-hydrochloride.
The behavior of the epithelial cells on the tongue and palatal processes during glosso-palatal fusion induced by Meclozine-hydrochloride was investigated with light and electron microscopes. Microscopical observations revealed that; at two or three days after the administration, the palatal processes were approximating to the tongue, and the superficial cells on the lateral sides of tongue became swollen and to have inclusion bodies, and in the epithelium on the medial sides of palatal processes, some inclusion bodies appeared too. At the time of contact, the superficial epithelial cells of tongue tended to degenerate markedly, and these degenerating cells were dissociated from the epithelium, and concurrently, superficial layer of the palatal epithelium became to have a lot of inclusion bodies. Between the two tissues, attachment devices developed just after the contact, and then, the cells in the intervening epithelial lining fell into a degeneration gradually. As well known, Meclozine-hydrochloride is one of important miner tranquilizers. From the findings mentioned above, it seemed to be possible that a heterotopic fusion caused with this drug is a result of a destruction of embryonic epithelium on tongue and palatal processes at a certain stage of development.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002448:Cell Adhesion; D002459:Cell Fusion / Q000187:drug effects; D002470:Cell Survival; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D002479:Inclusion Bodies / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000648:ultrastructure; D008468:Meclizine / Q000494:pharmacology*; D010159:Palate / Q000196:embryology* / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D014059:Tongue / Q000196:embryology* / Q000648:ultrastructure
D008468:Meclizine