[Serologic diagnosis of brain tumors using Clostridium butyrium spores (experimental and clinical studies)].
Spores of the Clostridium butyrium M 55 strain, introuduced intravenously, proliferate selectivity in tumours of individual with newgrowths forming bacilli and then multiply evoking the appearance of antibacillary antibodies. In persons with no tumours there emerge only antispore antibodies. Since the spores and bacilli of this strain have antigens of a different nature their antibodies are encountered separately. The finding of antibacillary antibodies following injection of spores thus serves as an indirect proof for the presence of a malignant tumour. In experiments on animals (rats) with neurogenic tumours induced with ethylnitosole urea and also in patients with brain tumours this phenomenon has been studied in detail.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000382:microbiology; D003013:Clostridium / Q000276:immunology; D005038:Ethylnitrosourea; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D013171:Spores, Bacterial / Q000276:immunology
D000907:Antibodies, Bacterial; D005038:Ethylnitrosourea
Serologicheskaia diagnostika opukholeĭ mozga s pomoshch'iu spor Clostridium butyrium (éksperimental'nye i klinicheskie issledovaniia)