Low responsiveness of synovial and peripheral blood lymphocytes stimulated by either PHA-P or CON-A in patients with chronic rheumatoid arthritis.
Lymphocytes were highly purified from synovial fluid and peripheral blood of 10 rheumatoid arthritis patients and assessed for responsiveness to PHA-P and Con-A. In all cases, both synovial and blood lymphocytes showed a marked reduction in response to these mitogens compared with normal blood lymphocytes. The factors responsible for this low T cell responsiveness are discussed.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002908:Chronic Disease; D003208:Concanavalin A / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013582:Synovial Fluid / Q000276:immunology
D010835:Phytohemagglutinins; D003208:Concanavalin A