[Possible role of cell contact in the control of a differentiation program in Dictyostelium discoideum].
Synthesis of cAMP-phosphodiesterase falls at the end of the aggregation phase in Dictyostelium discoideum. Exogenous cAMP pulses, known to induce they synthesis of that enzyme during the course of the aggregation process, do not prevent the shut off of enzyme synthesis. Specific intercellular contacts which form at the end of aggregation seem to be required for the inhibition of enzyme synthesis.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000096:biosynthesis; D000818:Animals; D002449:Cell Aggregation; D002454:Cell Differentiation; D000242:Cyclic AMP / Q000494:pharmacology*; D004023:Dictyostelium / Q000502:physiology*; D009235:Myxomycetes / Q000502:physiology*
D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Rôle possible des contacts cellulaires dans l'arrêt d'un programme de différenciation chez Dictyostelium discoideum