Successful treatment of a malignant gastrinoma with streptozotocin.
The treatment with streptozotocin of a patient with metastatic gastrinoma is described. Two courses of intravenous streptozotocin were without effect. However, three months after two doses of 4 g streptozotocin were given into the coeliac axis, there was a marked reduction in hepatic size and a fall in fasting plasma gastrin levels from 1430 pmol/l to 240 pmol/l. Seven months after treatment fasting plasma gastrin levels were 125 pmol/l.
D007516:Adenoma, Islet Cell / Q000601:surgery; D000328:Adult; D005260:Female; D005743:Gastrectomy; D005755:Gastrins / Q000097:blood; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000601:surgery; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000601:surgery; D013311:Streptozocin / Q000627:therapeutic use*; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy* / Q000601:surgery
D005755:Gastrins; D013311:Streptozocin