The effect of lergotrile on galactorrhea and gonadotropin secretion.
Lergotrile (Compound 83636), a specific inhibitor of prolactin release, was administered to 5 women with galactorrhea. Only 1 of the 5 had an elevated serum prolactin (hPRL) value, but Compound 83636 induced a decrease in serum hPRL in all cases. All patients had cessation of breast secretion within 72 days after initiation of lergotrile. LRH administration (100 pg) evoked a variable gonadotropin response before and during treatment with the ergot alkaloid. By contrast, serum prolactin values remained essentially unaltered after injection of LRH under the same conditions.
D000097:Acetonitriles / Q000494:pharmacology; D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects; D004873:Ergolines / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005687:Galactorrhea / Q000188:drug therapy* / Q000209:etiology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D007775:Lactation Disorders / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation; D008698:Mesylates / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000097:blood*; D013997:Time Factors
D000097:Acetonitriles; D003276:Contraceptives, Oral; D004873:Ergolines; D008698:Mesylates; D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone