Corticosteroid effect on eosinophils in vitro: ultrastructural studies.
The effect of corticosteroids, ultracortene and ACTH, on the eosinophilic cells of a patient with hypereosinophilic syndrome has been studied in vitro. Both drugs caused a marked decrease in the number of specific granules, a disappearance of their surrounding membrane and an almost complete destruction of their crystals. In addition, vacuolization of the cytoplasm, swelling of the mitochondria and distortion of their cristae were found. Incubation of the eosinophils with the antihistaminic drug mepyramine, did not produce ultrastructural alterations.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000368:Aged; D004804:Eosinophils / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D011738:Pyrilamine / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D011738:Pyrilamine