Differentiation of nephrotensin from the renin angiotensin system.
An investigation of the relationship between nephrotensin and the renin angiotensin system was carred out. Nephrotensin was found in the plasma of rats with renal clip hypertension and with chemically induced kidney damage. There was no demonstrable correlation between presence of nephrotensin and plasma renin activity, and the pressor activity of nephrotensin was not altered by previous immunization of test animals with angiotensin II nor by pretreatment with angiotensin I converting enzyme inhibitor. These results indicate that nephrotensin is different from the components of the renin-angiotensin system.
D000804:Angiotensin II / Q000097:blood* / Q000276:immunology / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D000906:Antibodies; D001285:Atropine / Q000494:pharmacology; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D006977:Hypertension, Renal / Q000097:blood* / Q000139:chemically induced; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced; D008297:Male; D008628:Mercury; D009392:Nephrectomy; D009638:Norepinephrine / Q000494:pharmacology; D010425:Pentolinium Tartrate / Q000494:pharmacology; D010455:Peptides; D051381:Rats; D012083:Renin / Q000097:blood; D013148:Spironolactone / Q000494:pharmacology; D013722:Teprotide / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000097:blood* / Q000302:isolation & purification
D000806:Angiotensin-Converting Enzyme Inhibitors; D000906:Antibodies; D010455:Peptides; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; C010897:corticotensin; D013148:Spironolactone; D001285:Atropine; D010425:Pentolinium Tartrate; D013722:Teprotide; D012083:Renin; D008628:Mercury; D009638:Norepinephrine