title: [Proposed model for evaluation of toxicity in antineoplastic chemo-hormonotherapy].
abstract: A detailed code for the evaluation of side-effects due to antiblastics in accordance with clinical, pharmacological and chronobiological parameters is described. Eight types of toxicity are recognised: systemic or local, cutaneous and adnexal, gastroenteric, haematochemical, cardiovascular, respiratory, genital and urinary, and nervous. Improvement of the objectivity and comparability of results in clinical oncology is proposed by means of a balanced points system for the expression of such effects, and methods for the summary expression of the toxicity of a single case or a uniform group of cases. The method of evaluation proposed also permits statistical comparison between different treatment protocols.
mesh_terms: D000505:Alopecia / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001247:Asthenia / Q000139:chemically induced; D002318:Cardiovascular Diseases / Q000139:chemically induced; D003875:Drug Eruptions; D004359:Drug Therapy, Combination; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D009120:Muscle Cramp / Q000139:chemically induced; D009369:Neoplasms / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D014570:Urologic Diseases / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Proposta di un modello di valutazione della tossicità in chemio-ormonoterapia antiblastica.