Immunologic aspects of 1, 2-dimethylhydrazine-induced colon tumors in rats.
Investigation of immunologic aspects of colon tumors induced in rats by 1,2-dimethylhydrazine demonstrated that: 1) An antigen in an extract of colon tumors was not detected in the normal colon. It was related to antigens in rat fetuses and did not cross-react immunologically with carcinoembryonic antigen. 2) Mucinous adenocarcinomas of the colon were significantly associated spatially with lymphoid follicles.
D000230:Adenocarcinoma / Q000139:chemically induced*; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced*; D000818:Animals; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000032:analysis*; D002272:Carcinoembryonic Antigen; D003106:Colon / Q000276:immunology; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000276:immunology* / Q000473:pathology; D003429:Cross Reactions; D004127:Dimethylhydrazines / Q000008:administration & dosage; D005333:Fetus / Q000276:immunology; D007441:Intubation, Gastrointestinal; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D051381:Rats
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D004127:Dimethylhydrazines