title: Hormone receptors, 5. Binding of glucagon and insulin to human circulating mononuclear cells in diabetes mellitus.
abstract: Preparations of human peripheral mononuclear leukocytes, containing over 85% lymphocytes, specifically bound glucagon and insulin. Binding of physiological concentrations of both hormones was seen to be substantially diminished when cells were derived from either adult-type diabetics or individuals with a unilateral genetic history of diabetes.
mesh_terms: D001665:Binding Sites; D003920:Diabetes Mellitus / Q000097:blood* / Q000235:genetics; D005934:Glucagon / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D009000:Monocytes / Q000378:metabolism*; D011485:Protein Binding; D011956:Receptors, Cell Surface
chemical_list: D007328:Insulin; D011956:Receptors, Cell Surface; D005934:Glucagon