title: Effects of cholinergic agonists and antagonists of nucleus vestibularis lateralis unit discharge to vestibular nerve stimulation in the cat.
abstract: Unit discharge in nucleus vestibularis (NVL) was studied in locally anesthetized cats. The mean firing rate +/-S.E. of spontaneous unitary discharges of NVL neurons was 19.8+/-0.9 Hz and that of spinal-transected animals was 18.0+/-1.6 Hz. The mean firing rate of these neurons in animals with cerebellum ablation and the administration of scopolamine in a dose of 0.5 mg/kg i.v. was relatively low. After administration of physostigmine in a dose of 25 mug/kg i.v. the firing rate was enhanced. The effects of physostigmine were antagonized by scopolamine. About 95% of NVL neurons activated by single electrical shocks to the ipsilateral vestibular nerve showed regular firing following administration of physostigmine. These neurons changed to a gamma distribution at lambda=2 following administration of scopolamine.
mesh_terms: D000818:Animals; D002415:Cats; D002531:Cerebellum / Q000601:surgery; D004558:Electric Stimulation; D005071:Evoked Potentials; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D010830:Physostigmine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology*; D013268:Stimulation, Chemical; D009435:Synaptic Transmission; D014725:Vestibular Nerve / Q000502:physiology*; D014726:Vestibular Nuclei / Q000187:drug effects* / Q000502:physiology
chemical_list: D010830:Physostigmine; D012601:Scopolamine