Idiopathic thrombocytopenic purpura in children.
Idiopathic thrombocytopenic purpura in children 10 years of age or younger was observed to have a more favorable prognosis than in older children. Corticosteroid therapy in children judged to be at increased risk of serious hemorrhage resulted in a significantly greater number of patients with an early increase in platelets than was noted in a control group. All patients with chronic disease who responded to administration of a corticosteroid initially and then relapsed had some response to a subsequent course of therapy, although none had a sustained remission. In such patients, splenectomy was a more effective therapeutic measure than treatment with either a corticosteroid or a cytotoxic agent.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000097:blood / Q000627:therapeutic use*; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000627:therapeutic use; D000367:Age Factors; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D001792:Blood Platelets / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003348:Cortisone / Q000627:therapeutic use; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D006487:Hemostasis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000150:complications / Q000628:therapy*; D012621:Seasons; D013156:Splenectomy
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D000324:Adrenocorticotropic Hormone; D001379:Azathioprine; D003348:Cortisone; D011241:Prednisone; D008775:Methylprednisolone