Autoantibodies in patients with bronchial carcinoma.
No overall increase in the incidence of antinuclear, smooth muscle or reticulin antibodies was observed in a group of 105 patients with bronchial carcinoma of various classified histological types. Smooth muscle antibody was, however, demonstrated in 27% of patients with undifferentiated carcinoma compared to 5% of controls (P less than 0-05). A highly significant increase in antinuclear antibodies in patients with adenocarcinoma was found (31% compared with 5% of controls--P less than 0-01). There as no apparent correlation between the presence of these antibodies and age, sex or other clinical features studied. A detailed study of the reproducibility of the antibody results, studied by indirect immunofluorescence in patients with bronchial carcinoma, is reported.
D000230:Adenocarcinoma / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001706:Biopsy; D001984:Bronchial Neoplasms / Q000276:immunology*; D001991:Bronchitis / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D006801:Humans; D009130:Muscle, Smooth / Q000276:immunology; D011863:Radioimmunoassay; D012155:Reticulin / Q000276:immunology; D013183:Sputum / Q000166:cytology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D012155:Reticulin