On the diuretic action produced dibutyryl cyclic AMP in dogs.
Experiments were undertaken on order to elucidate the mechanism  of diuresis induced by dibutyryl cyclic AMP in dogs. Intravenous injections of dibutyryl cyclic AMP produced an increase in urine flow in dogs hydrated with saline. It was also noted that dibutyryl cyclic AMP produced an increase in myocardial contraction, renal blood flow and glomerular filtration rate; In addition, unilateral injection of dibutyryl cyclic AMP into the left renal artery produced diuresis bilaterally. Based on the above findings it was suggested that the diuretic action induced by dibutyryl cyclic AMP is associated with its hemodynamic effect.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000098:blood supply; D009200:Myocardial Contraction / Q000187:drug effects; D011188:Potassium / Q000652:urine; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000652:urine; D013268:Stimulation, Chemical; D014556:Urine
D004232:Diuretics; D003994:Bucladesine; D012964:Sodium; D011188:Potassium