A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.
Purified rat liver peroxisomes contain a cyanide-insensitive fatty acyl-CoA oxidizing system that uses O2 and NAD as electron acceptors. The system was detected by the ability of added palmitoyl-CoA to elicit O2 consumption, H2O2 production, and O2-dependent NAD reduction. The activity of this system is increased approximately one order of magnitude in rats treated with clofibrate, a hypolipidemic drug known to cause peroxisomal proliferation.
D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D003065:Coenzyme A / Q000378:metabolism*; D008099:Liver / Q000648:ultrastructure; D008830:Microbodies / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009940:Organoids / Q000378:metabolism*; D010084:Oxidation-Reduction; D010168:Palmitates / Q000378:metabolism; D051381:Rats
D010168:Palmitates; D009243:NAD; D002994:Clofibrate; D003065:Coenzyme A