Denervation in the primary olfactory pathway of mice. II. Effects on carnosine and other amine compounds.
Carnosine (beta-alanyl-histidine) is present in the olfactory bulb and olfactory eqithelium of mice and rats at 1-2 nmole/mg tissue. Peripheral deafferentation or central denervation causes a rapid, selective decrease of this depeptide from the reciprocal portion of the primary olfactory pathway. These data demonstrate the localization of carnosine within the primary olfactory chemoreceptor neurons and suggest a possible role for this compound in neural transmission.
D000409:Alanine / Q000032:analysis; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis; D002336:Carnosine / Q000032:analysis*; D002531:Cerebellum / Q000032:analysis; D003619:Dansyl Compounds / Q000032:analysis; D003714:Denervation; D004151:Dipeptides / Q000032:analysis*; D005260:Female; D005971:Glutamates / Q000032:analysis; D008239:Lysine / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009830:Olfactory Bulb / Q000032:analysis*; D009831:Olfactory Mucosa / Q000032:analysis*; D051381:Rats; D012694:Serine / Q000032:analysis; D013045:Species Specificity; D009435:Synaptic Transmission; D013654:Taurine / Q000032:analysis; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D003619:Dansyl Compounds; D004151:Dipeptides; D005971:Glutamates; D013654:Taurine; D001224:Aspartic Acid; D012694:Serine; D005680:gamma-Aminobutyric Acid; D002336:Carnosine; D008239:Lysine; D000409:Alanine