Inhibition by levamisole of metastases by cells transformed by herpes simplex virus type I.
Levamisole was tested to determine whether the drug could reduce metastases by HSV-1-transformed cells in a model hamster system. The results presented reveal an inhibition of metastases to the lungs even when the drug is inoculated after development of subcutaneous tumors at the site of inoculation of the cells.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D018139:Simplexvirus; D013997:Time Factors; D014184:Transplantation, Homologous
D007978:Levamisole