Cerebrospinal fluid hormone concentration in the evaluation of pituitary tumors.
Cerebrospinal fluid (CSF) concentrations of corticotropin, growth hormone, thyrotropin, prolactin, luteinizing hormone, and follicle stimulating hormone were measured in 28 patients with various neurologic disorders, in 49 patients with pituitary tumors of whom 22 had suprasellar extension, and in 6 patients with craniopharyngiomas. With the exception of 1 patient with pseudotumor cerebri, CSF adenohypophyseal hormone concentrations were low in patients with neurologic disease and in patients with pituitary tumor without suprasellar extension. In marked contrast, 21 to 22 patients with suprasellar extension of a pituitary tumor and 2 of 6 patients with a craniopharyngioma had elevations of one or more CSF adenohypophyseal hormones. Posttreatment CSF adenohypophyseal hormone levels fell from previously elevated levels in 4 of 5 patients. These data suggest that an elevated CSF adenohypophyseal hormone concentration is a sensitive indicator of suprasellar extension of a pituitary tumor, and posttreatment measurements are useful in determining efficacy of therapy.
D000239:Adenoma, Acidophil / Q000134:cerebrospinal fluid*; D000238:Adenoma, Chromophobe / Q000134:cerebrospinal fluid*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid; D000328:Adult; D000368:Aged; D003560:Cysts / Q000134:cerebrospinal fluid; D005260:Female; D005640:Follicle Stimulating Hormone / Q000134:cerebrospinal fluid; D013006:Growth Hormone / Q000134:cerebrospinal fluid; D006801:Humans; D007986:Luteinizing Hormone / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000134:cerebrospinal fluid; D010908:Pituitary Hormones, Anterior / Q000134:cerebrospinal fluid*; D010911:Pituitary Neoplasms / Q000134:cerebrospinal fluid*; D011388:Prolactin / Q000134:cerebrospinal fluid; D013724:Teratoma / Q000134:cerebrospinal fluid*; D013972:Thyrotropin / Q000134:cerebrospinal fluid
D010908:Pituitary Hormones, Anterior; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone