A case of multiple sclerosis associated with defective neuromuscular transmission.
A 38-year-old woman developed relapsing disseminated sclerosis associated with myasthenic syndrome. The cerebrospinal fluid showed 12 lymphocytes per 1 mul and paretic colloidal curve. The serum contained antibody against smooth muscle antigen (titre 1 : 10) but no antibody against nuclear antigen or VDRL antigen. Repetitive stimulation of the right ulnar nerve at 35 c/sec. demonstrated typical decrements between 70 and 72%. The prostigmine test showed significant diminishing of decrements. The possible immunopathological mechanism of myasthenic syndrome in multiple sclerosis was briefly discussed.
D000328:Adult; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D009157:Myasthenia Gravis / Q000150:complications; D009469:Neuromuscular Junction; D009435:Synaptic Transmission; D013577:Syndrome