Transcriptional and post-transcriptional control of beta-galactosidase synthesis.
lac messenger ribonucleic acid synthesis is dissociated from its translation in certain lac operon mutants. More beta-galactosidase messenger ribonucleic acid (as determined by hybridization) is made in fully induced lacOc mutants and in trp-lac fusions than is eventually translated into enzyme. Consequently, beta-galactosidase synthesis may be post-transcriptionally controlled under these conditions.
D000242:Cyclic AMP / Q000494:pharmacology; D004794:Enzyme Repression; D004926:Escherichia coli / Q000201:enzymology* / Q000378:metabolism; D005696:Galactosidases / Q000096:biosynthesis*; D007785:Lactose / Q000378:metabolism; D009154:Mutation; D009876:Operon; D014176:Protein Biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D014158:Transcription, Genetic
D012329:RNA, Bacterial; D012333:RNA, Messenger; D000242:Cyclic AMP; D005696:Galactosidases; D007785:Lactose