Adrenal function during chronic danazol administration.
Ten healthy female volunteers received Danazol, 400 mg twice daily for 90 days. Adrenal function testing then showed a normal capacity of the gland to respond to stimulation with synthetic adrenocorticotrophic hormone, and a lack of suppression of central areas controlling adrenal function by a normal response to the metyrapone challenge.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000304:Adrenal Cortex Function Tests; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone; D003613:Danazol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D008797:Metyrapone; D011245:Pregnadienes / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D013268:Stimulation, Chemical
D015065:17-Hydroxycorticosteroids; D011245:Pregnadienes; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D003613:Danazol; D006854:Hydrocortisone; D008797:Metyrapone