[Quantitative model of human erythrocyte glycolysis. Region of cell viability determined by ATP concentration].
The boundaries of the cell vitality domain in the enzyme activity space are calculated on the basis of a mathematical model of erythrocyte glycolysis. The boundaries are determined by key metabolite concentrations. The results obtained are compared with experimental data related to erythrocytic enzymopathies. It is shown that theoretical boundary enzyme activities coincide with the activities of hexokinase and in some cases phosphofruktokinase in enzyme deficient erythrocytes.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000743:Anemia, Hemolytic / Q000378:metabolism; D000746:Anemia, Hemolytic, Congenital Nonspherocytic; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D006019:Glycolysis; D006593:Hexokinase / Q000172:deficiency / Q000378:metabolism; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D010732:Phosphofructokinase-1 / Q000378:metabolism
D000970:Antineoplastic Agents; D000255:Adenosine Triphosphate; D006593:Hexokinase; D010732:Phosphofructokinase-1; D000251:Adenosine Triphosphatases; D005956:Glucose-6-Phosphate Isomerase
Kolichestvennaia model' glikoliza éritrotsita cheloveka. Oblast' zhiznesposobnosti kletki, opredeliaemaia kontsentratsieĭ ATF.