Influence of cyclic nucleotides on protein synthesis in vascular smooth muscle.
The incorporation of leucine-14C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10-3 M) and decreased by cyclic AMP (10-3 M). There was no effect of 5'AMP (10-3 M). The phosphodiesterase inhibiting drugs theophylline (10-3 M) and papaverine (5 x 10-5 g/ml) both decreased the leucine-14C incorporation.
D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D002417:Cattle; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D008638:Mesenteric Arteries; D009124:Muscle Proteins / Q000096:biosynthesis*; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010208:Papaverine / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D000621:Aminoisobutyric Acids; D009124:Muscle Proteins; D013806:Theophylline; D010208:Papaverine; D000242:Cyclic AMP; D007930:Leucine; D006152:Cyclic GMP