In vivo studies of parainfluenza I (6/94) virus: mononuclear cell interactions.
Adsorption to and penetration of migratory mononuclear cells in vivo by Para-influenza I (6/94) virus were documented by electron microscopy during the acute phase of an experimental meningoencephalitis in ICR mice. Phagocytosis of virions was the apparent and predominant mode of viral entry into these cells. Penetration by fusion was also seen. Nucleocapsids were replicated by the mononuclear cells which became a potential reservoir for the further spread of virus.
D000327:Adsorption; D000818:Animals; D002831:Choroid Plexus / Q000382:microbiology; D004195:Disease Models, Animal; D004805:Ependyma / Q000382:microbiology; D007181:Inclusion Bodies, Viral; D008264:Macrophages / Q000382:microbiology*; D008590:Meningoencephalitis / Q000382:microbiology*; D051379:Mice; D008813:Mice, Inbred ICR; D010222:Parainfluenza Virus 1, Human / Q000254:growth & development* / Q000648:ultrastructure; D018184:Paramyxoviridae Infections / Q000382:microbiology*; D010587:Phagocytosis; D014617:Vacuoles / Q000382:microbiology