Pilot studies with human interferon in Herpesvirus saimiri-induced lymphoma in owl monkeys.
The nature of Herpesvirus saimiri-induced disease in owl monkeys is described with emphasis on those biological parameters useful in monitoring the disease. These parameters are lymphocyte response to general mitogens, lymphocyte-infective centers, and antibody to virus-associated early antigen. Human interferon was used in treating owl monkeys with virus-induced leukemia. In 2 animals evidence was obtained that suggested a positive antileukemic effect.
D000818:Animals; D000917:Antibody Formation; D001029:Aotus trivirgatus; D000882:Haplorhini; D006564:Herpesviridae; D006567:Herpesvirus 2, Saimiriine; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D009374:Neoplasms, Experimental / Q000188:drug therapy