title: Mouse or man? Which are pertussis vaccines to protect?
abstract: Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the naso-pharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1,2 or 1,3 infection persisted for many weeks. As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain. A vaccine (extract or whole cell) containing agglutinogen 1 may be sufficient to pass the mouse protection test but it may fail to immunize children. The mouse test is inadequate even for the screening of such extracts.
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial; D001886:Bordetella pertussis / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D001921:Brain / Q000382:microbiology; D002143:Callitrichinae; D002648:Child; D000882:Haplorhini; D006801:Humans; D051379:Mice; D009305:Nasopharynx / Q000382:microbiology; D010567:Pertussis Vaccine; D011817:Rabbits; D012703:Serotyping; D014917:Whooping Cough / Q000517:prevention & control* / Q000635:transmission
chemical_list: D000942:Antigens, Bacterial; D010567:Pertussis Vaccine