Auto-reaction phenomenon detected by enzyme electrosyneresis in the serum of patients with viral hepatitis and other diseases with immune complexes.
The use of modified electrosyneresis by making 760 sera of healthy persons or persons suffering from various diseases with immune complexes to react with their own pronase-treated serum has shown the following results: - One of 220 sera of healthy persons, 11 were positive in ESE (5%); - Out of 123 sera of HBsAg carriers, 23 were positive (18.6%); - Out of 135 sera of patients with acute viral type B hepatitis, 132 were positive (97.7%); - Out of 168 sera of patients with acute HBsAg negative hepatitis, 127 were positive (75.5%); - 4 cases of fulminant hepatitis were all strongly positive; - 54 cases of patients with rheumatoid arthritis were 100% positive; - 2 cases of patients with systemic lupus erythematosus were positive; - Out of 6 patients with glomerulonephritis 3 were positive; - Out of 34 patients with carcinoma of various organs, 19 were positive (55.88%). The Authors believe, on the basis of the research work set forth partly in the present report, that this interaction is connected with the presence of immune complexes. The method used has been called Enzyme Electrosyneresis (ESE) and the detected antigen "Auto antigen exposed by protease and by electrosyneresis" (AEPE).
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D011232:Chemical Precipitation; D002769:Cholelithiasis / Q000175:diagnosis; D003378:Counterimmunoelectrophoresis; D005921:Glomerulonephritis / Q000175:diagnosis; D006509:Hepatitis B / Q000175:diagnosis; D006514:Hepatitis B Surface Antigens; D006525:Hepatitis, Viral, Human / Q000175:diagnosis*; D006801:Humans; D007105:Immune Complex Diseases / Q000175:diagnosis*; D007122:Immunoelectrophoresis; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis; D011817:Rabbits
D006514:Hepatitis B Surface Antigens