[Effect of diphenylhydantoin administered during gestation and lactation on the motor development and cerebellar histology of the young rat].
Rattus norvegicus females were treated by diphenylhydantoin (D.P.H.), all along pregnancy and lactation. 4 groups were constituted: a 100 mg DPH/kg/day group, a 50 mg DPH/kg/day group; a placebo group (treated with pure water), and control group. D.P.H. was given twice a day by a gastric tube. The cerebellar Purkinje cells studied through light microscopy and transmission electron microscopy in young rats (25 days old) showed no visible alteration. 2 motorcoordination tests were applied to the young rats, during their 2nd and 3rd weeks of post-natal life. Young rats of DPH 100, DPH 50 and placebo groups showed a backwardness relatively to control. This backwardness may be attributed to the maternal forced feeding stress, but not to a specific action of the DPH.
D000818:Animals; D000833:Animals, Suckling; D002531:Cerebellum / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D008431:Maternal-Fetal Exchange; D009048:Motor Skills / Q000187:drug effects*; D010672:Phenytoin / Q000494:pharmacology*; D011247:Pregnancy; D011689:Purkinje Cells / Q000187:drug effects; D051381:Rats
D010672:Phenytoin
Action de la diphénylhydantoïne administrée pendant la gestation et l'allaitement, sur le développement moteur et l'histologie du cervelet du jeune rat.