Paget's disease of the breast.
Criteria of the morphological diagnosis as well as the histogenesis of the lesions in Paget's disease are presented; the authors claim that the initial lesion occurs in the lactiferous ducts, the skin being secondarily involved. Likewise, the dyskeratotic lesions are considered as secondary to the neoplastic process, either by neoplastic induction or by mobilization and proliferation of cancerous cells from lactiferous ducts. The utility of biopsies in all cases of nipple eczema, and of the histologic investigation of the profound tissues is pointed out. In this way the canalicular starting point in the vicinity of the nipple can be noticed.
D001940:Breast / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating; D005260:Female; D006801:Humans; D010144:Paget's Disease, Mammary / Q000473:pathology / Q000601:surgery