Treatment of transplanted rat tumours with double-stranded RNA(BRL 5907). II. Treatment of pleural and peritoneal growths.
Intrapleural growth of transplanted rat tumours was prevented or retarded by intrapleural administration of double-stranded RNA. A similar suppression of growth was achieved with peitoneal tumours by the intraperitoneal injection of the compound. These studies indicate the possible potential of this form of treatment of thoracic and peritoneal tumours for clinical application in the treatment of mesothelioma.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002470:Cell Survival; D005260:Female; D007274:Injections, Intraperitoneal; D008113:Liver Neoplasms; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D010997:Pleural Neoplasms / Q000188:drug therapy*; D012367:RNA, Viral / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013997:Time Factors; D014185:Transplantation, Isogeneic
D012367:RNA, Viral