Studies on FeSV induced sarcomata in sheep with particular reference to the regional lymphatic system.
Inocula of cultured sheep cells that had been transformed with FeSV were injected into the legs of sheep so that the changes in the cellular and humoral composition of the efferent lymph from the regional node could be studied throughout the immune responses. The times at which immunoblasts and specific antibodies appeared in the lymph were similar to those recorded during responses to conventional antigens. The antiboides were mainly 7S, G1 immunoglobulins directed against virion antigens on the membranes of the transformed cells.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D000917:Antibody Formation; D002415:Cats; D002471:Cell Transformation, Neoplastic; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology / Q000473:pathology; D007074:Immunoglobulin G; D008196:Lymph / Q000276:immunology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009858:Oncogenic Viruses; D005253:Sarcoma Viruses, Feline; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology; D012756:Sheep
D000912:Antibodies, Neoplasm; D007074:Immunoglobulin G