title: A controlled study of prednisone therapy in infantile spasms.
abstract: A controlled study of 12 patients with infantile spasms was performed to determine the effectiveness of prednisone treatment. Patients were monitored serially, using a time-synchronized polygraphic and video system. Three patients (25%) showed prompt reduction in seizure frequency and normalization of the EEG after institution of treatment. The remaining patients showed no improvement in seizure frequency or significant change in the EEG.
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications; D002648:Child; D002657:Child Development / Q000187:drug effects; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004314:Down Syndrome / Q000150:complications; D004341:Drug Evaluation; D004569:Electroencephalography; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000150:complications; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D013036:Spasms, Infantile / Q000188:drug therapy* / Q000209:etiology; D014402:Tuberous Sclerosis / Q000150:complications
chemical_list: D011241:Prednisone