Effect of DNA-negative and maturation-defective conditions on accumulation of functional messengers for T4 bacteriophage-specific dihydrofolate reductase and deoxynucleoside monophosphate kinase.
Messengers for T4 phage-specific deoxynucleoside monophosphate kinase overaccumulated in nonpermissive hosts infected with amber-defective viruses that displayed either the DNA-negative or maturation-defective phenotype. Under both conditions, however, transcription of functional messengers for dihydrofolate reductase followed essentially normal kinetics.
D003090:Coliphages / Q000254:growth & development / Q000378:metabolism*; D004267:DNA Viruses; D004279:DNA, Viral / Q000096:biosynthesis; D007700:Kinetics; D009154:Mutation; D010641:Phenotype; D010770:Phosphotransferases / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D012367:RNA, Viral / Q000096:biosynthesis*; D012293:Rifampin / Q000494:pharmacology; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014779:Virus Replication
D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral; D013762:Tetrahydrofolate Dehydrogenase; D010770:Phosphotransferases; D012293:Rifampin