[Long-term treatment of bradycardia by means of an atropine ester (SCH 1000). Electrophysiological and clinical results].
Electrophysiological effects of the atropin ester Ipatropiumbromide (SCH 1000) were investigated in 15 patients by His electrocardiography and high frequency atrial stimulation. Heart rate increased by 50% of base line heart rate, PA- and AH-intervals and sinus node recovery time decreased, the HF-interval remained unchanged. Physiological av-block by atrial stimulation occurred at significant higher stimulation frequencies with SCH 1000 than without medication. Additional 15 patients were treated for a longer follow-up period. Increase of resting heart rate averaged 15%. Equivocal effects on heart rate were found with exercise after SCH 1000. Non-cardiac side effects were found in 5 patients.
D000328:Adult; D000368:Aged; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001919:Bradycardia / Q000188:drug therapy*; D002036:Bundle of His / Q000187:drug effects*; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D006325:Heart Atria; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D001286:Atropine Derivatives; D009241:Ipratropium
Langzeitbehandlung der Bradykardie mit einem Atropinester (SCH 1000). Elektrophysiologische und klinische Ergebnisse.