Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.
Corticosteroids as well as non-steroid anti-inflammatory drugs inhibit the prostaglandin-mediated vasodilatation accompanying lipolysis in subcutaneous fat. Whereas the non-steroids produce their effect by inhibition of prostaglandin synthesis, however, corticosteroids inhibit their release. This mechanism may be the basis of some actions of corticosteroids in inflammation, in the gastric mucosa and in the CNS.
D000273:Adipose Tissue / Q000098:blood supply / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001623:Betamethasone / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D050356:Lipid Metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology; D011453:Prostaglandins / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D005938:Glucocorticoids; D011453:Prostaglandins; D000324:Adrenocorticotropic Hormone; D001623:Betamethasone; D011239:Prednisolone; D006854:Hydrocortisone