[Aminoacyl-tRNA formation in the liver and skeletal muscles of rabbits under the influence of multiple injections of ACTH alone and in combination with sodium ribonucleinate].
A study was made of the action mechanism of ACTH. ACTH (10 Units/kg) alone or in combination with sodium ribonucleinate (10 mg/kg) was injected to rabbits for 14 days, daily. Sum total tRNA and aminoacyl-tRNA-synthetases were extracted from the liver and the skeletal muscles. tRNA acetylation with lysine-1-C14, leucine-1-C14 and alanine-1-C14 was investigated in vitro in homologous systems. It was found that repeated ACTH injections led to a decrease in the intensity of aminoacyl-tRNA formation in the liver and the skeletal muscles. When ACTH was injected in combination with sodium ribonucleinate formation of aminoacyl-tRNA was much more intensive in both organs than when ACTH was injected alone.
D000215:Acylation; D000217:Acyltransferases / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000586:Amination; D000596:Amino Acids; D000818:Animals; D004347:Drug Interactions; D004357:Drug Synergism; D005938:Glucocorticoids / Q000502:physiology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D012313:RNA / Q000008:administration & dosage / Q000494:pharmacology*; D012343:RNA, Transfer / Q000096:biosynthesis*; D011817:Rabbits; D013268:Stimulation, Chemical; D013997:Time Factors
D000596:Amino Acids; D005938:Glucocorticoids; D012313:RNA; D000324:Adrenocorticotropic Hormone; D012343:RNA, Transfer; D000217:Acyltransferases
Obrazovanie aminoatsil-tRNK v pecheni i skeletnykh myshtsakh krolikov pod vliianiem mnogokratnykh in'ektsiĭ AKTG odnogo i v sochetanii s ribonukleinatom natriia