Tumorigenicity of mouse-human diploid hybrids in nude mice.
Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D013539:Simian virus 40 / Q000254:growth & development* / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral