The effects of protein deprivation on cell-mediated immunity.
The effect of protein insufficiency on immune responsiveness was investigated in inbred mice fed isocaloric diets low and normal in protein. Mice were tested for aberrations of cell-mediated and humoral immunities. Protein insufficiency enhances cell-mediated immunity while depressing or not affecting humoral immunity. Cell-mediated immunity was enhanced in testing: allogeneic skin graft rejection, spleen cell responsiveness to phytohemagglutinin, the graft-vs-host reaction, macrophage function, and resistance to viral and bacterial infections.
D000818:Animals; D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D002478:Cells, Cultured; D004044:Dietary Proteins; D005260:Female; D011558:Herpesvirus 1, Suid / Q000276:immunology; D007111:Immunity, Cellular; D037102:Lectins; D008089:Listeria monocytogenes / Q000276:immunology; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D010587:Phagocytosis; D011488:Protein Deficiency / Q000209:etiology / Q000276:immunology; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D013291:Streptococcus / Q000276:immunology; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology; D014184:Transplantation, Homologous
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D004044:Dietary Proteins; D037102:Lectins