Possible identity between the hepatoma alkaline phosphatase and an isozyme of human amniotic membrane (FL cells).
The electrophoretically faster migrating alkaline phosphatase isozyme in FL cells derived from the human amniotic membrane was similar in some of the enzymatic and immunochemical properties to the variant alkaline phosphatase which occurs in serum and cancerous tissue of some patients with hepatocellular carcinoma. These facts suggest that the hepatoma-associated alkaline phosphatase may be the resurgence of the isozyme originally present in the amniotic membrane.
D000469:Alkaline Phosphatase / Q000032:analysis*; D000650:Amnion / Q000201:enzymology*; D000818:Animals; D002277:Carcinoma / Q000201:enzymology*; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D003429:Cross Reactions; D004589:Electrophoresis, Disc; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007527:Isoenzymes / Q000032:analysis*; D008113:Liver Neoplasms; D011247:Pregnancy; D011817:Rabbits / Q000276:immunology
D007527:Isoenzymes; D000469:Alkaline Phosphatase