title: [Reversible bactericidal defect of leukocytes. Pseudomonas meningitis in a child with diabetes mellitus (author's transl)].
abstract: A 3-year-old boy with diabetes mellitus contracted meningitis caused by Pseudomonas aeruginosa. The disease lasted for several months in spite of antibiotic treatment. Diabetes mellitus was poorly controlled and hypoglycemia often occured. Immunoglobulin levels were normal. Investigations of leukocyte functions showed (no bactericidal activity), decreased phagocytic activity and very low NBT dye reduction by neutrophils during phagocytosis. Under the administration of polymixin, leukocyte transfusions and stabilization of glycemia the pathological clinical and laboratory findings disappeared within three weeks. Serial investigations of leukocyte function showed a gradual recovery of normal activity.
mesh_terms: D001803:Blood Transfusion; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007962:Leukocytes; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy; D010587:Phagocytosis; D011113:Polymyxins / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000150:complications* / Q000188:drug therapy
chemical_list: D007136:Immunoglobulins; D011113:Polymyxins
vernacular_title: Reversibler bakterizidaler Leukozyten-Defekt: Pseudomonas Meningitis und Diabetes mellitus