Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs.
1 The effects of non-steroidal anti-inflammatory drugs on gastric acid secretion and mucosal blood flow were studied in the rat. 2 Indomethacin, in ulcerogenic doses, caused a dose-dependent rise in pentagastrin-stimulated acid secretion, but decreased mucosal blood flow per unit acid secretion. 3 During resting conditions, indomethacin had no significant effect on acid output, but reduced mucosal blood flow. 4 Pretreatment with indomethacin, phenylbutazone or meclofenamate potentiated the secretory response to dibutyryl cyclic adenosine 3',5'-monophosphate. 5 Indomethacin markedly reduced the mucosal prostaglandin-like activity at a time when mucosal erosion formation had reached steady levels. 6 These results provide evidence that prostaglandins have a local role in the regulation of blood flow and acid secretion in the rat gastric mucosa, and suggest that non-steroidal anti-inflammatory drugs cause mucosal erosions by disrupting these processes.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism; D003994:Bucladesine / Q000378:metabolism; D003864:Depression, Chemical; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism*; D066298:In Vitro Techniques; D010418:Pentagastrin / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D001798:Blood Proteins; D011453:Prostaglandins; D014665:Vasodilator Agents; D003994:Bucladesine; D010418:Pentagastrin