Receptor for 5alpha-dihydrotestosterone from Streptomyces hydrogenans.
Streptomyces hydrogenans exhibits binding activity for 5alpha-dihydrotestosterone (17 beta-hydroxy-5alpha-androstan-3-one) in vivo. A cell free homogenate from the microorganism binds 5alpha-dihydrotestosterone in vitro as well. The association constant is 10(8) M-1 at 4 degrees C. Progesterone, but neither testerone nor cyproterone, competes with 5alpha-dihydrotestosterone for binding. The binding fraction from Streptomyces hydrogenans permits a simple assay for 5 alpha-dihydrotestosterone in biological samples.
D001667:Binding, Competitive; D001681:Biological Assay; D002474:Cell-Free System / Q000378:metabolism; D013196:Dihydrotestosterone / Q000032:analysis / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D011956:Receptors, Cell Surface; D013302:Streptomyces / Q000378:metabolism*
D011956:Receptors, Cell Surface; D013196:Dihydrotestosterone; D011374:Progesterone