Correlation between drug induced changes of acetylcholine release and acetylcholine fractions in rat brain.
After administration of eserine, a new acetylcholine (ACh) subfraction called f+ is formed in rat brain tissue. References and methods are given for the calculation of this subfraction, which can be isolated and determined only together with the so-called "free" ACh fraction. Alterations of the f+-ACh subfraction caused by barbital, urethane, pentetrazol, arecoline and scopolamine in telencephalon, cortex and striatum of rat brain are connected with changes of ACh concentrations determined in comparable releasing tests.
D000109:Acetylcholine / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001681:Biological Assay; D001921:Brain / Q000378:metabolism*; D005260:Female; D007082:Ileum / Q000187:drug effects; D008297:Male; D009132:Muscles / Q000187:drug effects; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission
D010830:Physostigmine; D000109:Acetylcholine