Microangiopathic haemolytic anaemia in cancer patients with bone marrow infiltration.
Eight patients suffering from wide-spread malignancies presented with a severe microangiopathic haemolytic anaemia (MHA) without gross evidence for coagulation abnormalities. The common feature in these patients was bone marrow infiltration with malignant cells, suggesting a pathogenic link between bone marrow carcinosis and red cell destruction. Furthermore, it is concluded that MHA is a rare complication of malignancy and a terminal syndrome rather than an early manifestation of the disease.
D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D001663:Bilirubin / Q000097:blood; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000209:etiology
D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D001663:Bilirubin