Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.
Long-term p.o. treatment with dehydroepiandrosterone, an adrenal steroid found in subnormal plasma concentrations in women predisposed to develop breast cancer, inhibits the formation of spontaneous mammary cancer in female C3H(Avy/a) mice.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001943:Breast Neoplasms / Q000209:etiology; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000172:deficiency / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors; D006801:Humans; D008321:Mammary Glands, Animal / Q000201:enzymology; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D013997:Time Factors
D003687:Dehydroepiandrosterone; D005954:Glucosephosphate Dehydrogenase