Vincristine toxicity unrelated to dose.
Four children with vincristine toxicity unrelated to dose are described. Fever, haematological toxicity, and abdominal distension occurred 2-7 days after vincristine was given. Convulsions occurred 6-8 days after vincristine in all 4. Inappropriate secretion of antidiuretic hormone was thought to have occurred in 3 patients. 2 patients died during the acute toxicity phase. Necropsy findings did not show neuronal changes which could be directly ascribed to vincristine.
D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced; D009994:Osmolar Concentration; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced; D014750:Vincristine / Q000627:therapeutic use / Q000633:toxicity*; D009396:Wilms Tumor / Q000188:drug therapy
D014750:Vincristine