The control of adaptive hypertrophy in the salt glands of geese and ducks.
1. Factors controlling adaptive hypertrophy, which occurs when marine, or potentially marine, birds drink salt water, have been investigated in geese and ducks using changes in salt-weight weight, RNA and DNA contents as indices of this process. 2. Unilateral post-ganglionic denervation in geese prevented the changes in [RNA] and [RNA]:[DNA] that occurred in the intact gland of birds given salt water for 24 hr; denervation had no significant effect in birds on fresh water throughout. 3. Atropine treatment also prevented the adaptive changes in geese given salt water. 4. In ducks give 0.3 M-NaCl for 48 hr salt-gland weight, [RNA] and [RNA]:[DNA] increase markedly. Treatment of ducks drinking fresh water with large doses of corticosterone and mammalian ACTH for 48 hr had no significant effects on salt-gland weight, RNA or DNA; mammalian prolactin treatment for 48 hr significantly raised [RNA]. 5. No changes in the total amount of DNA in the glands were observed in these experiments, thus indicating that hyperplasia does not occur within 48 hr of a bird first drinking salt water. 6. It is concluded that adaptive hypertrophy is controlled by secretory nerves, and that hormones, if they play any part in this process, have a permissive or secondary role. It is suggested that hypertrophy and the maintenance of the secretory cells in the fully-adapted state may be obligatorily related to secretory activity induced by cholinergic secretory nerves.
D000222:Adaptation, Physiological; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003345:Corticosterone / Q000494:pharmacology; D004247:DNA / Q000032:analysis; D003714:Denervation; D004372:Ducks; D005618:Fresh Water; D005777:Geese; D006984:Hypertrophy / Q000503:physiopathology*; D009929:Organ Size; D012313:RNA / Q000032:analysis; D012491:Salt Gland / Q000032:analysis / Q000502:physiology*
D012313:RNA; D001285:Atropine; D000324:Adrenocorticotropic Hormone; D004247:DNA; D003345:Corticosterone