Role of the vagus in control of the major conduit coronary artery in the dog.
Using El Badawi and Schenk's modification of Karnovski's method for the demonstration of acetylcholinesterase, the authors found cholinergic fibres both in the perivascular connective tissue and directly in the wall (in the adventitia) of the major coronary arteries; the fibres were distributed regularly around the circumference of the arteries. In the case of the smaller intramyocardial arteries, the cholinergic fibres were concentrated at two poles of the blood vessel; none were present in the wall of the veins. The shape and topography of the coronary cholinergic arterial plexus resemble the shape and topography of the coronary sympathetic adrenergic system. In apparent contradiction of this finding, stimulation of the cervical vagus did not affect the diameter of the large coronary arteries. Since acetylcholine (6--10 micrograms/kg i.v.) produced a mean 7.4% increase in the diameter of the ramus interventricularis ventralis, we concluded that there are no postgangliar cholinergic fibres of vasomotor significance for the large coronary arteries in the cervical vagus. The specific acetylcholinesterase activity found in the wall of these vessels belongs either to cholinergic terminals whose ganglion cells are not located in the vagal ganglion, or to cholinergic axones terminating outside the wall of the large coronary arteries.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002799:Cholinergic Fibers / Q000033:anatomy & histology; D003331:Coronary Vessels / Q000201:enzymology / Q000294:innervation / Q000502:physiology*; D004285:Dogs; D005260:Female; D006651:Histocytochemistry; D008297:Male; D014630:Vagus Nerve / Q000502:physiology*; D014661:Vasoconstriction; D014664:Vasodilation
D000110:Acetylcholinesterase