Effect of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the immediate and delayed hypersensitivity reactions.
Effects of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the experimental models of the type I-IV allergic reactions were studied in comparison with those of disodium cromoglycate (DSCG), dexamethasone and other agents. AA-344 showed inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. However, it had only a slight or little effect on the Forssman shock in guinea pigs, the complete-dependent cytolysis of mast cells in rats, the Arthus reaction in guinea pigs and the tuberculin reaction and the contact sensitivity in mice. DSCG was less effective, using these experimental models. Dexamethasone showed a suppressive effect on the type III and IV allergic reactions. The results indicate that AA-344 selectively suppresses the type I allergic reaction.
D000818:Animals; D001183:Arthus Reaction / Q000188:drug therapy; D002867:Chromones / Q000494:pharmacology / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000494:pharmacology / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000188:drug therapy; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D006968:Hypersensitivity, Delayed / Q000188:drug therapy*; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D008297:Male; D008407:Mast Cells / Q000473:pathology; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use; D014373:Tuberculin / Q000276:immunology
D002867:Chromones; D013777:Tetrazoles; D014373:Tuberculin; C018537:6-ethyl-3-(1H-tetrazol-5-yl)chromone; D003907:Dexamethasone; D004205:Cromolyn Sodium