Studies of herpes simplex virus and interferon in human gingival cell cultures.
Cultures of human gingival fibroblast cells from patients with a positive or negative history of recurrent herpes simplex virus (HSV) infection were compared with respect to susceptibility to HSV infection and interferon activity. There was a possible inverse relationship between interferon sensitivity of gingival fibroblast cells and a clinical history of recurrent disease. No correlation was found between prior infection and other parameters of interferon activity or susceptibility of the cells to HSV.
D000914:Antibodies, Viral; D002478:Cells, Cultured; D002646:Chikungunya virus / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology; D005881:Gingiva / Q000166:cytology / Q000276:immunology*; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D007372:Interferons / Q000378:metabolism / Q000502:physiology*; D009522:Newcastle disease virus / Q000276:immunology; D012008:Recurrence; D018139:Simplexvirus / Q000276:immunology*; D012845:Sindbis Virus / Q000276:immunology; D013280:Stomatitis / Q000209:etiology; D014762:Viral Interference
D000914:Antibodies, Viral; D007372:Interferons