Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.
N-Hydroxymethylacrylamide, N-methylacrylamide, and N,N-diethylacrylamide produce peripheral neuropathy in rats. Seven other compounds related to acrylamide do not produce neuropathy. Rats given one of the three neurotoxic compounds are more susceptible to acrylamide. A regime for testing acrylamide analogues for neuro-toxicity is suggested. DDT, phenobarbitone, or high dietary concentrations of vitamin A or E have no effect on the development of acrylamide neuropathy in rats. Acrylamide produces neuropathy in hens but not in frogs or goldfish.
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001917:Brachial Plexus / Q000473:pathology; D002645:Chickens; D003634:DDT / Q000494:pharmacology; D005260:Female; D006054:Goldfish; D008297:Male; D009410:Nerve Degeneration; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D010543:Peroneal Nerve / Q000473:pathology; D010634:Phenobarbital / Q000494:pharmacology; D011896:Rana temporaria; D051381:Rats; D012584:Sciatic Nerve / Q000473:pathology; D013045:Species Specificity; D013116:Spinal Cord / Q000473:pathology; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000178:Acrylamides; D014801:Vitamin A; D014810:Vitamin E; D003634:DDT; D010634:Phenobarbital