Dopamine- and apomorphine-sensitive adenylate cyclase in homogenates of rabbit retina.
Dopamine (0.5-100 muM) as well as apomorphine (1-100 muM) were found to be potent stimulators of adenylate cyclase in homogenates of rabbit retina. When compared with the dopamine-effect at 10 muM, half-stimulation was also obtained in response to noradrenaline or adrenaline, whereas isoprenaline or phenylephrine were ineffective. Furthermore, the dopamine-induced production of cyclic AMP wab blocked by chloropromazine and haloperidol. These data would suggest the occurrence of a specific "dopamine receptor" in the retina of the rabbit.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis; D004298:Dopamine / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011817:Rabbits; D011955:Receptors, Drug; D012160:Retina / Q000201:enzymology*; D013268:Stimulation, Chemical; D013347:Subcellular Fractions / Q000201:enzymology
D018492:Dopamine Antagonists; D011955:Receptors, Drug; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006220:Haloperidol; D007545:Isoproterenol; D001058:Apomorphine; D002746:Chlorpromazine; D004298:Dopamine; D004837:Epinephrine; D010646:Phentolamine