title: Cyclic nucleotide phosphodiesterases: properties, activators, inhibitors, structure--activity relationships, and possible role in drug development.
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001581:Benzothiadiazines / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D002460:Cell Line; D000242:Cyclic AMP; D006152:Cyclic GMP; D004194:Disease / Q000201:enzymology; D004232:Diuretics / Q000494:pharmacology; D004789:Enzyme Activation; D006571:Heterocyclic Compounds / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D009711:Nucleotides / Q000378:metabolism; D010208:Papaverine / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases / Q000302:isolation & purification; D011619:Psychotropic Drugs / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D013453:Sulfonylurea Compounds / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D001581:Benzothiadiazines; D002395:Catecholamines; D004232:Diuretics; D006571:Heterocyclic Compounds; D006728:Hormones; D007093:Imidazoles; D007211:Indoles; D007546:Isoquinolines; D009711:Nucleotides; D010726:Phosphodiesterase Inhibitors; D011619:Psychotropic Drugs; D011725:Pyridines; D011804:Quinolines; D013439:Sulfhydryl Reagents; D013453:Sulfonylurea Compounds; D014970:Xanthines; D010208:Papaverine; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP