title: Sexual precocity associated with a hypothalamic tumour. Effects of sex hormone therapy.
abstract: A case of sexual precocity of unusually early onset and associated with a hypothalamic tumour is described. The effects of ethinyl oestradiol and medroxyprogesterone acetate treatment have been monitored by plasma testosterone, FSH, and LH estimations. The results suggested a partial suppression of the tumour's influence, the mechanism of which is discussed.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000365:Age Determination by Skeleton; D001932:Brain Neoplasms / Q000150:complications*; D002675:Child, Preschool; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000652:urine; D006801:Humans; D007031:Hypothalamus / Q000000981:diagnostic imaging / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D011629:Puberty, Precocious / Q000188:drug therapy / Q000209:etiology*; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood
chemical_list: D015068:17-Ketosteroids; D006065:Gonadotropins, Pituitary; D013739:Testosterone; D004997:Ethinyl Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008525:Medroxyprogesterone