The effect of antilipolytic agents on cyclic AMP, free fatty acid and total catecholamine concentrations in plasma.
Plasma concentrations of adenosine 3':5' cyclic monophosphate (cyclic AMP) and free fatty acids have been measured in 15 patients with acute myocardial infarction and in 6 dogs given infusions of isoprenaline. Plasma total catecholamines were also estimated in the patients. Inhibition of adipose tissue lipolysis with a nicotinic acid analogue did not decrease plasma cyclic AMP concentrations, either in the patients or when elevated in the dogs, thus suggesting that this tissue is not a major source of the nucleotide in plasma.
D000208:Acute Disease; D000818:Animals; D002395:Catecholamines / Q000097:blood*; D002986:Clinical Trials as Topic; D000242:Cyclic AMP / Q000097:blood*; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000097:blood; D009539:Nicotinic Acids / Q000494:pharmacology*; D010919:Placebos
D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D009539:Nicotinic Acids; D010919:Placebos; D000242:Cyclic AMP; D007545:Isoproterenol