Chronic cytomegalovirus infection, immunodeficiency, and monoclonal gammopathy-antigen-driven malignancy?
An infant with severe combined immunodeficiency had normal numbers of lymphocytes which bore E rosette and surface Ig markers in an appropriate distribution. However, only minimal responsivity to in vitro stimulation by mitogens and allogenic cells, and none to antigens could be elicited; functional antibody responses were also nil, except to cytomegalovirus. Intrauterine-acquired cytomegalovirus may have caused his immune dysfunction, although the possibility of a postnatal infection cannot be excluded. Therapy with transfer factor and thymus transplantation was unsucessful in restoring immunity and may have aggravated a pre-existing monoclonal gammopathy. It is possible that the monoclonal protein was derived from B-cells transplacentally received from the patients mother.
D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D008214:Lymphocytes / Q000276:immunology; D008934:Mitogens / Q000276:immunology; D012882:Skin Tests
D000941:Antigens; D007074:Immunoglobulin G; D008934:Mitogens