title: Physiologic consequences of hepatic lobectomy in man.
abstract: Replacement of glucose and albumin in ten patients after hepatic lobectomy shows that hypoglycemia and hypoalbuminemia, the two most common consequences of lobectomy in animals, can be prevented in man. Biosynthesis of protein, cholesterol, and prothrombin are reduced temporarily. In patients having emergency lobectomy, the serum bilirubin and glutamic oxaloacetic transaminase concentrations are statistically greater than in patients having elective lobectomy. Serum ammonia is not elevated and bromsulphalein excretion is normal after bilirubin returns to less than 1 mg/100 ml. Lactic dehydrogenase concentrations in serum are increased and fluctuate in the presence of sepsis or respiratory insufficiency: Mean creatine phosphokinase peaks at concentrations higher than those reported in acute myocardial infarction and returns to normal in three days. Compensatory hyperplasia of the residual  lobe occurred in all patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D003402:Creatine Kinase / Q000097:blood; D004573:Electrolytes / Q000097:blood; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000601:surgery*; D008113:Liver Neoplasms / Q000601:surgery; D008115:Liver Regeneration; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D008055:Lipids; D012709:Serum Albumin; D002245:Carbon Dioxide; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D000469:Alkaline Phosphatase; D001663:Bilirubin