Effect of aspirin and dexamethasone on intraocular pressure in primary uveitis produced by Herpes simplex virus.
The intracameral injection of New Zealand white male rabbits with type 1 herpes simplex virus produced acute anterior uveitis with biphasic elevation of the intraocular pressure (IOP). The first IOP increase occurred on day 1 and 2 and the second increase on day 8. There was no significant correlation between the IOP changes and multiplication of herpes simplex virus in the uvea and cornea, nor between the IOP changes and histopathologic alteration of the tissue. Aspirin suppressed significantly the first as well as the second IOP elevation, whereas dexamethasone suppressed significantly only the second elevation.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D005123:Eye / Q000473:pathology; D007429:Intraocular Pressure / Q000187:drug effects*; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D008297:Male; D009887:Ophthalmoscopy; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects / Q000254:growth & development; D014605:Uveitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
D003907:Dexamethasone; D001241:Aspirin