A comparison of some immunological methods for the differentiation of strains of foot-and-mouth disease virus.
Two FMDV strains which had been previously differentiated by complement-fixation were compared by guinea-pig protection test, kinetic neutralization and micro-neutralization tests. It was found that these tests, which have not been previously applied by the methods described, were all capable of FMDV strain differentiation. Similar differences were found by all methods, which suggests that comparisons made by cross-CF, cross-neutralization or cross-protection involve measurement of the same antigen/antibody interactions.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral / Q000032:analysis; D005537:Aphthovirus / Q000145:classification / Q000276:immunology*; D003168:Complement Fixation Tests; D003429:Cross Reactions; D006168:Guinea Pigs / Q000276:immunology; D007106:Immune Sera; D007158:Immunologic Techniques; D007700:Kinetics; D009500:Neutralization Tests; D012703:Serotyping
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007106:Immune Sera