Stimulation of sugar transport in rat diaphragm by 8-bromoguanosine 3', 5'-monophosphate.
The cyclic GMP derivative, 8-bromo cyclic GMP, increases the uptake of D-xylose and of 2-deoxy D-glucose into intact rat diaphragm incubated in vitro. 8-Bromo cyclic GMP does not stimulate the incorporation of [14C]glucose into glycogen in the diaphragm, or the uptake of alphalpha-amino isobutyric acid into this tissue. The effect of 8-bromo cyclic GMP on the diaphragm is consistent with the hypothesis that cyclic GMP plays a role in the regulation of sugar transport in muscle.
D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D003964:Diaphragm / Q000187:drug effects / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis; D007328:Insulin / Q000494:pharmacology; D051381:Rats; D014994:Xylose / Q000378:metabolism*
D000621:Aminoisobutyric Acids; D003837:Deoxy Sugars; D007328:Insulin; D006003:Glycogen; D003847:Deoxyglucose; D014994:Xylose; D006152:Cyclic GMP; D005947:Glucose