Comparison of the effects of ethinyl oestradiol and conjugated equine oestrogens in oophorectomized women.
Seventeen oophorectomized women were treated for 3 month periods, in random sequence, with ethinyl oestradiol 20 and 50 mug daily and conjugated equine oestrogens (Premarin)0-625 and 1-25 mg daily. The serum cholesterol, clot lysis time, plasma fibrinogen, platelet adhesiveness and activated partial thromboplastin time remained unchanged throughout the different oestrogen regimes. There was a significant rise of serum triglyceride levels on both doses of ethinyl oestradiol but no significant change with Premarin. Serum luteinizing hormone levels were depressed most by ethinyl oestradiol 50 mug daily, although no down to the levels in premenopausal women.
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001797:Blood Protein Electrophoresis; D002369:Castration; D002784:Cholesterol / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010973:Platelet Adhesiveness / Q000187:drug effects; D011863:Radioimmunoassay; D013925:Thromboplastin; D014280:Triglycerides / Q000097:blood
D004966:Estrogens, Conjugated (USP); D014280:Triglycerides; D004997:Ethinyl Estradiol; D005340:Fibrinogen; D007986:Luteinizing Hormone; D013925:Thromboplastin; D002784:Cholesterol