Cytokine inhibition of DNA synthesis: effect on cyclic adenosine monophosphate in lymphocytes.
A greater than twofold increase in intracellular adenosine 3',5'-monophosphate (cyclic AMP) inhibited DNA synthesis, in stimulated rat lymphocytes. A two- to fourfold rise of intracellular cyclic AMP, starting at 16 hours, was produced by purified inhibitor od DNA synthesis added to such cells either at 0 or 16 hours, in close association with the initiation of DNA synthesis.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002455:Cell Division; D000242:Cyclic AMP / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D037102:Lectins; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D008222:Lymphokines / Q000494:pharmacology*; D051381:Rats
D037102:Lectins; D008222:Lymphokines; D003994:Bucladesine; D004247:DNA; D000242:Cyclic AMP