Kainic acid binding in human caudate nucleus: effect of Huntington's disease.
Kainic acid binding was measured in crude membrane fractions prepared from postmortem human caudate tissue of control persons and patients afflicted with Huntington's disease. A significant reduction in binding sites with no change in affinity was found in the Huntington's tissue, the apparent dissociation constants (Kd) and maximal binding (Bmax) values were: 6.4 nM/119 fmol/mg protein (control) and 5.9 nM/53 fmol/mg protein (Huntington). The kainic acid binding showed a remarkable specificity for L-glutamate.
D001667:Binding, Competitive; D002421:Caudate Nucleus / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D007608:Kainic Acid / Q000378:metabolism*; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000378:metabolism*; D013237:Stereoisomerism
D005971:Glutamates; D011759:Pyrrolidines; D007608:Kainic Acid