title: [Cytogenetic mechanisms in the pathogenesis of malignant neoplasms].
abstract: Malignant tumors and pre-cancer processes are characterized by a high proliferative activity of cells, high chromosome variability and extremely high genome variability which is 10 times, as high as that in non-tumor actively proliferating tissues. A clear positive correlation is found between the cell division rate and the level of chromosome variability.
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000235:genetics; D000236:Adenoma / Q000235:genetics; D000818:Animals; D002645:Chickens; D005260:Female; D005350:Fibroma / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000235:genetics; D008938:Mitosis; D009369:Neoplasms / Q000235:genetics*; D009463:Neuroma / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics; D001357:Sarcoma, Avian / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics
vernacular_title: Tsitogeneticheskie zakonomernosti patogeneza zlokachestvennykh novoobrazovaniĭ