Interactions between central monoaminergic systems: dopamine-serotonin.
Concentration of dopamine and serotonin metabolites (HVA and 5-HIAA) in the CSF was evaluated before and after pharmacological treatment in 19 patients with different neuropsychiatric diseases. In every case a reciprocal modification of the two metabolites occurred after treatment. The result supports the hypothesis of a functional balance between the monoaminergic systems in the central nervous system.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid; D003863:Depression / Q000134:cerebrospinal fluid; D004298:Dopamine / Q000134:cerebrospinal fluid*; D004409:Dyskinesia, Drug-Induced / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid; D012701:Serotonin / Q000134:cerebrospinal fluid*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid