The improving hematologic picture in long-term surviving calves with total artificial hearts.
A coagulopathy associated with severe hemolysis was a limiting factor in obtaining long-term survivors among calves with total artificial hearts in 1969. Conversion of design from sac-type hearts to flexible diaphragm hearts, and from Silastic Dacron-fibril intimas to smooth polyurethane intimas, resulted in an abatement of the coagulopathy. In the most recent series of animals studied at this laboratory, platelet counts are normal and platelet survivals are half of normal. Plasma hemoglobins are normal. The coagulation system is still activated at specific loci within the total artificial heart, but is best compensated for in calves treated with antiplatelet drugs, having polyurethane hearts.
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001769:Blood; D001778:Blood Coagulation Disorders / Q000517:prevention & control*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000166:cytology; D002417:Cattle; D005337:Fibrin / Q000378:metabolism; D006350:Heart Valve Prosthesis; D006354:Heart, Artificial; D006454:Hemoglobins / Q000032:analysis; D010973:Platelet Adhesiveness; D011093:Polyethylene Terephthalates; D011140:Polyurethanes; D011474:Prosthesis Design; D012826:Silicone Elastomers; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control*
D000925:Anticoagulants; D006454:Hemoglobins; D011093:Polyethylene Terephthalates; D011140:Polyurethanes; D012826:Silicone Elastomers; D005337:Fibrin