Cross-sensitivity within the neomycin group of antibiotics.
Neomycin sensitive patients were tested for hypersensitivity to kanamycin, gentamycin, tobramycin, spectinomycin and to the new, not yet registered sisomycin and netilmicin. Cross-sensitivity occured in a considerable part of the patients, except for spectinomycin, the structure of which is basically different from that of the other aminoglycosides tested. The common occurence of cross-sensitivity between neomycin and other aminoglycoside antibiotics shows that it is possible to predict cross-sensitivity between a new drug and an old sensitizing one before clinical reactions from the new drug have occured. Such an investigation should be performed before adopting new antibiotics.
D000617:Aminoglycosides / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000209:etiology*; D005839:Gentamicins / Q000009:adverse effects; D006801:Humans; D007612:Kanamycin / Q000009:adverse effects; D009355:Neomycin / Q000009:adverse effects*; D009428:Netilmicin / Q000009:adverse effects; D012853:Sisomicin / Q000009:adverse effects; D000198:Spectinomycin / Q000009:adverse effects; D014031:Tobramycin / Q000009:adverse effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D007612:Kanamycin; D000198:Spectinomycin; D009355:Neomycin; D014031:Tobramycin; D012853:Sisomicin