title: [Some physicochemical properties of the dysenteric therapeutic--prophylactic Newcastle phages H-17 and H-18 (Author's transl)].
abstract: Some physico-chemical properties of dysentery therapeutic-prophylactic Newcastle-phages H-17 and H-18 were studied. Both phages were shown to be resistant to sodium dodecyl sulphate at room temperature. Phage H-17 at room temperature was completely inactivated and phage H-18 inactivated by 40% by 1 M sodium hydrochloride. Phage H-18 was completely inactivated by 4 M sodium hydrochloride. Morphology and sizes of the phages are described. The buoyant density of phage H-17 was found to be 1.497 g/cm3,  and of phage H-18 1.504 g/cm3. DNA of both phages were identified as double-stranded on the basis of the pattern of melting curve, of interaction with formaldehyde and absorption spectrum in solutions with various ionic strengths. The melting point of DNA of phage H-17 is 83.63 degrees C, phage H-18 89.67 degrees.
mesh_terms: D001433:Bacteriolysis; D001435:Bacteriophages / Q000032:analysis* / Q000187:drug effects / Q000648:ultrastructure; D002458:Cell Fractionation; D002499:Centrifugation, Density Gradient; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002848:Chromatography, DEAE-Cellulose; D004279:DNA, Viral / Q000032:analysis; D008055:Lipids / Q000032:analysis; D010472:Perchlorates / Q000494:pharmacology; D012367:RNA, Viral / Q000032:analysis; D012763:Shigella flexneri; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013054:Spectrophotometry, Atomic; D013696:Temperature; D014461:Ultracentrifugation; D014764:Viral Proteins / Q000032:analysis
chemical_list: D004279:DNA, Viral; D008055:Lipids; D010472:Perchlorates; D012367:RNA, Viral; D014764:Viral Proteins; D012967:Sodium Dodecyl Sulfate
vernacular_title: Nekotorye fiziko-khimicheskie svoĭstva dizenteriĭnykh lechebno--profilakticheskikh N' iukasl-fagov H-17 and H-18