title: Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. I. High avidity complexes and mesangiopathic glomerulonephritis.
abstract: Intravenous injection of mice with soluble complexes of highly avid rabbit antibody to egg albumin, prepared by dissolution of equivalence precipitates in large quantities of antigen, resulted in a purely mesangial localization of the complexes. When animals received three injections of complexes per day for 1 day it was noted that precipitates dissolved in 80 times the equivalence amount of antigen produced slight mesangial changes. When such complexes were injected for 2 or 3 days, outright mesangiopathic glomerulonephritis was observed in an increasing proportion of the animals. Equivalent amounts of antigen alone did not produce lesions.
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000008:administration & dosage; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000473:pathology*; D007105:Immune Complex Diseases / Q000473:pathology*; D007668:Kidney / Q000276:immunology / Q000648:ultrastructure*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D011817:Rabbits; D013997:Time Factors
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D010047:Ovalbumin