title: The effects of adenine nucleotides and guanine nucleotides on urate synthesis de novo by isolated chick liver and kidney cells.
abstract: Isolated chick liver and kidney cells produce urate de novo from glycine, and this is partially inhibited by 1 mm-AMP and by 1 mm-GMP in liver cells but not in kidney cells. Azaserine fully inhibits this synthesis de novo, but attempts to isolate formylglycine amide ribonucleotide from azaserine-blocked cells were unsuccessful.
mesh_terms: D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D001377:Azaserine / Q000494:pharmacology; D002645:Chickens; D006152:Cyclic GMP / Q000494:pharmacology; D005998:Glycine / Q000032:analysis / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D012267:Ribosemonophosphates / Q000032:analysis; D014527:Uric Acid / Q000096:biosynthesis*
chemical_list: D012267:Ribosemonophosphates; D014527:Uric Acid; D000249:Adenosine Monophosphate; D001377:Azaserine; D006152:Cyclic GMP; D005998:Glycine