title: The nitrofurans as sperm immobilising agents: their tissue toxicity and their clinical application.
abstract: Nitrofurantoin sodium and nitrofurazone in certain critical concentrations have the ability to cause sperm immobilisation. Intraoperative vas irrigation with these solutions in 24 patients have produced sterility in the immediate postoperative period.
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007246:Infertility; D008297:Male; D009581:Nitrofurans / Q000494:pharmacology* / Q000633:toxicity; D013078:Sperm Immobilizing Agents / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects; D013092:Spermatogenesis-Blocking Agents; D013094:Spermatozoa / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects; D014659:Vasectomy / Q000379:methods
chemical_list: D009581:Nitrofurans; D013078:Sperm Immobilizing Agents; D013092:Spermatogenesis-Blocking Agents