Efficacy of exogenous interferon treatment initiated after onset of multiplication of vesicular stomatitis virus in the brains of mice.
Initiation of treatment with potent interferon preparations (6-4 x 10-6 units per dose) 4 days after intranasal inoculation of VSV (at a time when virus has already multiplied in the brains of most mice) resulted in a marked increase in mouse survival. In a series of 6 experiments only 11 to 18% of control mice survived whereas 52% of interferon treated mice survival. These results suggest the usefulness of exogenous interferon even when treatment is begun late in the course of an acute virus disease.
D000818:Animals; D001921:Brain / Q000382:microbiology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012376:Rodent Diseases / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development*; D014777:Virus Diseases / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D014779:Virus Replication
D007372:Interferons