Antiviral 1,3,4-thiadiazoles. II. Effects on cellular and viral RNA synthesis in Mengo-virus-infected FL cells.
Three antiviral 1,3,4-thiadiazoles caused, when incubated together with 3H-uridine, a reduction of the incorporation rate into acid-insoluble material of FL cells. Using the method of prelabelling cellular RNA synthesis was not remarkably influenced. However, the substances tested act as specific inhibitors of the virus-induced RNA synthesis.
D000998:Antiviral Agents; D003609:Dactinomycin / Q000494:pharmacology; D008574:Mengovirus / Q000187:drug effects* / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D012367:RNA, Viral / Q000096:biosynthesis*; D013830:Thiadiazoles / Q000494:pharmacology*; D014529:Uridine / Q000378:metabolism
D000998:Antiviral Agents; D012367:RNA, Viral; D013830:Thiadiazoles; D003609:Dactinomycin; D012313:RNA; D014529:Uridine