Noradrenaline-secreting glomus jugulare tumor with cyclic change of blood pressure.
A glomus jugulare tumor secreted a large quantity of noradrenaline (NA) and produced symptoms of tinnitus, palpitation, sweating, and labile hypertension. The NA content of the tumor was 0.75 mg/gm of tissue. Electron microscopical study of the tumor demonstrated many membrane-limited osmiophilic granules. This indicates the capacity of the tumor not only to synthesize but also to store NA in the tumor. Continuous blood pressure recording showed a cyclic change of blood pressure with a cycle length of 10 to 17 minutes that terminated after intravenous doses of phentolamine (0.1 mg/kg) or diazoxide (4.5 mg/kg) and surgical removal of the tumor.
D001794:Blood Pressure / Q000187:drug effects; D003981:Diazoxide / Q000494:pharmacology; D004837:Epinephrine / Q000652:urine; D005260:Female; D005925:Glomus Jugulare Tumor / Q000378:metabolism / Q000503:physiopathology; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008676:Metanephrine / Q000652:urine; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D010236:Paraganglioma, Extra-Adrenal; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D014642:Vanilmandelic Acid / Q000652:urine
D010643:Phenoxybenzamine; D008676:Metanephrine; D014642:Vanilmandelic Acid; D003981:Diazoxide; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine