Carcinogenicity of 1,2-dimethylhydrazine dihydrochloride in BALB/c mice. Influence of the route of administration and dosage.
The carcinogenicity of 1,2-dimethylhydrazine dihydrochloride (DMH) by oral, intragastric and subcutaneous administration was examined in 339 BALB/c mice. Subcutaneous injection of DMH induced intestinal tumors in the lower colon of all mice. After oral administration it induced a high incidence of vascular tumors in the liver and soft tissues, but colon tumors were found in only 2 mice when given at a high dosage. On intragastric administration, it induced a fairly high incidence both of colon and vascular tumors. The sites and incidences of vascular tumors and squamous cell carcinomas of the perianal glands were also described.
D000284:Administration, Oral; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007279:Injections, Subcutaneous; D007441:Intubation, Gastrointestinal; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D009383:Neoplasms, Vascular Tissue / Q000139:chemically induced; D012983:Soft Tissue Neoplasms / Q000139:chemically induced
D004127:Dimethylhydrazines; D008763:Methylhydrazines