A genetic model of narcolepsy.
An analysis of recently published family history data on rapid eye movement (REM) narcolepsy was undertaken to determine the goodness-of-fit of a multifactorial (MF) model of inheritance. The analysis revealed that a two-threshold MF model can successfully account for the prevalence of REM narcolepsy and other disorders of excessive sleep (DES) observed in the first-degree relatives of the REM narcoleptic probands studied.
D006801:Humans; D009290:Narcolepsy / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D012306:Risk; D012895:Sleep, REM