[Sarcomatous and leukemic forms of Waldenström's macroglobulinemia].
Four cases of sarcomatous or leukaemic types of Waldenström's macroglobulinemia are presented. They are characterized by tumoral and compressive localizations of lymph node or spleen, or by a hyper-leukocytosis with many circulating abnormal cells. These cells are different from the lympho-plasma cells regularly observed in Waldenström's macroglobulinemia, and can be assimilated to malignant immunoblasts. They have a proliferative aspect and seem to produce less macroglobulin and to recover some beta-glucuronidase activity. The sarcomatous and leukemic types of Waldenström's macroglobullinemia have a poor prognosis and may appear as terminal transformation of the disease.
D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000648:ultrastructure; D012509:Sarcoma / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013160:Splenic Neoplasms / Q000209:etiology / Q000276:immunology / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000276:immunology / Q000473:pathology
D007074:Immunoglobulin G; D007075:Immunoglobulin M
Formes sarcomateuses et leucémiques de la macroglobulinémie de Waldenström