Canine adenovirus type 2-induced immunity to two canine adenoviruses in pups with maternal antibody.
Twenty-four Beagle pups with high levels of maternal antibody to canine adenovirus type 1 (CAV-1) and canine adenovirus type 2 (CAV-2) were oronasally inoculated with CAV-2 at 4 weeks of age. The CAV-2 was isolated from pharyngeal swabs on postinoculation days 2 through 6. In spite of the infection, maternal antibody continued to decrease for 4 to 8 postinoculation weeks, and then homologous CAV-2 neutralizing antibody and, to a lesser extent, CAV-1 neutralizing antibody began to increase. When these pups were challenge inoculated with CAV-1 and CAV-2 at a time when maternal antibody to CAV-1 would normally have disappeared, they were immune. In addition, 3 pups with maternal antibody to CAV-1 and CAV-2 were intramuscularly inoculated with CAV-2 at 3 weeks of age. Virus was not isolated from these pups, and maternal antibody decreased at a normal rate. These pups were not immune to challenge inoculation with CAV-1 and CAV-2.
D000256:Adenoviridae / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D006516:Adenoviruses, Canine / Q000276:immunology*; D000281:Administration, Intranasal; D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral / Q000008:administration & dosage; D002478:Cells, Cultured; D004285:Dogs / Q000276:immunology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D007273:Injections, Intramuscular; D007668:Kidney; D008431:Maternal-Fetal Exchange; D009500:Neutralization Tests; D010614:Pharynx / Q000382:microbiology; D011247:Pregnancy; D013552:Swine
D000914:Antibodies, Viral; D000956:Antigens, Viral