[Effects of diethyldithiocarbamate on the acute toxicity and the acetylcholinesterase inhibition by methylparathion in mice].
Acute toxicity of methylparathion male mice is reduced by DET in dose-range from 50 to 300 mg/kg. Mean survival time in LD100 range of methylparathion is significantly prolonged. Inhibition of AChE in vivo is reduced, too. The observed dose-effect-relations show an approx. 10-fold increase in equi-effective doses after DET-pretreatment. DET has no protective effect both in vivo and in vitro, if methylparathion is added to the brain homogenate of mice. As probable mechanism of action a change in methylparathion-metabolism induced by DET in the system of mixed functional oxidases is discussed.
D000284:Administration, Oral; D000818:Animals; D002800:Cholinesterase Inhibitors; D004050:Ditiocarb / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D008743:Methyl Parathion / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008861:Microsomes; D010278:Parathion / Q000031:analogs & derivatives*; D013859:Thiocarbamates / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D013859:Thiocarbamates; D008743:Methyl Parathion; D010278:Parathion; D004050:Ditiocarb
Zur Beeinflussung der akuten Toxizität und der Azetylcholinesterasehemmwirkung von Methylparathion durch Diäthyldithiokarbamat bei Mäusen