Potential anticancer agents, XI. X-ray structure determination of acantholide.
The X-ray structure of acantholide, a melampolide sesquiterpene lactone from Acanthospermum glabratum (DC.) Willd. was determined by the aid of direct methods. The compound was cytotoxic but displayed no antitumor activity. Evaluation of the X-ray and NMR data indicated that the same conformation exists in the solid state as in solution.
D000972:Antineoplastic Agents, Phytogenic; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012717:Sesquiterpenes; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes