[Incorporation of radiolabel in vitro into proteins of rat hippocampus synaptosomes when elaborating defensive conditioned reflexes].
The influence of learning local protein synthesis was studied in the rat hippocampal synaptosomes. It is found that elaboration of two-way avoidance conditioned reflex causes a decrease in ability of hippocampal synaptosomes to include H3-leucin into proteins in experiments in vitro. It is suggested that cyclic adenosin 3'5'-monophosphate plays a definite role in controlling protein synthesis in the nerve endings during different influences including learning because its addition to the incubation medium activates sharply this process.
D000818:Animals; D001362:Avoidance Learning; D003214:Conditioning, Classical; D000242:Cyclic AMP / Q000494:pharmacology; D003674:Defense Mechanisms; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D000242:Cyclic AMP
Vkliuchenie radioadtivnoĭ metki in vitro v belki sinaptosom gippokampa krys pri vyrabotke oboronitel'nykh uslovnykh refleksov