title: Intranuclear inclusions in mammotrophs of the Mongolian gerbil: effect of low doses of estradiol benzoate and a study of females before weaning.
abstract: The effect of dose of estrogen on induction of intranuclear inclusions was studied in mammotrophs of the Mongolian gerbil. The number of inclusions per high power field increased significantly with 0-5 and 1-0 mug/day of estradiol benzoate but not with the 0-05 mug dose. A form of inclusion was seen in young female gerbils before weaning which suggests that inclusions arise from the cytoplasm. Intranuclear inclusions develop soon after weaning of gerbils (0-06 +/- 0-01 vs. 0-19 +/- 0-03 for young mature females).
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005849:Gerbillinae; D002479:Inclusion Bodies / Q000187:drug effects* / Q000648:ultrastructure; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000648:ultrastructure*; D011132:Polyribosomes / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure; D014886:Weaning
chemical_list: D004958:Estradiol