[Diabetogenic and atherogenic effects of glucose].
Tests were set up on 59 albino male-rats with reproduced functional overstress and depletion of the insular system of the pancreas thorough a long-term (for 50, 100 days) peroral introduction of glucose (2 g/100 g body weight, every other day) and with and alloxan-induced diabetes (achieved by poisoning the animals with a 2.5% alloxan solution, 15 mg/100 g administered in a single dose intraperitoneally). A comparison of the data obtained ascertained the presence of a number of similar pathobiochemical changes in the metabolism, viz. hyperglycemia, an increase of the free cholesterol fraction, a diminution of the bound cholesterol fraction and a fall of the insulin-like activity (ILA) in the blood serum, a rise in glycogen and beta-lipoproteids in the liver; morphologically--a reduced count of Langerhan's islands beta-cells, less intensive colouration of the specific granulation in their cytoplasma manifestations of vacuolar and granular dystrophy of the liver. Further tests were staged on 23 rabbits involving a long-term introduction of glucose (in amounts of 25 g/kg every other day) and a cholesterol-induced atherosclerosis (by administering 0.2 g/kg of cholesterol in oil, daily), which also showed similar changes in the figures of the carbohydrate and fat-lipoids metabolism, such as hyperglycemia, an increased level of total lipids, cholesterol and its fractions, beta-lipoproteids, a fall of ILA in the blood serum, as well as variations in the morphological picture of the aortic wall. The above findings suggest that a protracted administration of glucose can produce both diabetogenic and atherogenic effects.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000473:pathology; D004040:Dietary Carbohydrates; D005947:Glucose; D006943:Hyperglycemia / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology; D008077:Lipoproteins, LDL / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D011817:Rabbits; D051381:Rats
D004040:Dietary Carbohydrates; D007328:Insulin; D008077:Lipoproteins, LDL; D008112:Liver Glycogen; D002784:Cholesterol; D005947:Glucose
O diabetogennom i aterogennom deĭstvii gliukozy