Immunity to C-type RNA viruses: antibody formation after natural or deliberate infection.
A combined virologic and immunologic study was done in mice that were either naturally or deliberately infected with C-type RNA viruses. In about 60% of B10. A mice, natural infection was accompanied by detectable anti-VEA antibodies in the serum. The absence of such antibodies was a reliable indicator of the absence of virus in B10 mice. Deliberately infected young adult B10 mice failed to eliminate the virus completely, despite high titers of anti-VEA antibodies. B10 mice exposed to B tropic viruses at birth made anti-VEA antibodies but failed to eliminate the virus. By contrast, some NIH Swiss mice exposed to N-tropic virus at birth made anti-VEA antibodies and eliminated the virus.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D007109:Immunity; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008892:Milk; D012328:RNA Viruses / Q000276:immunology* / Q000302:isolation & purification; D012190:Retroviridae / Q000276:immunology; D013997:Time Factors; D014412:Tumor Virus Infections / Q000276:immunology* / Q000635:transmission
D000914:Antibodies, Viral