Cholesterol metabolism in hypertriglyceridaemia and the effects of treatment.
The faecal output of bile acids and endogenous neutral steroids was increased in three hypertriglyceridaemic patients. One patient had familail type IIb, one had type IV and the third had type V hyperlipoproteinaemia. The hyperlipidaemia in the type IV and type V patients was associated with diabetes and a high alcohol intake. The plasma cholesterol and triglyceride concentrations and the faecal output of bile acids decreased significantly when the type IIb patient was given D-thyroxine plus propranolol, and when the type IV and type V patients were treated by withdrawal of alcohol, a low=carbohydrate diet and insulin or glibenclamide. The findings are discussed in relation to the possibility that hypertriglyceridaemia and increased bile acid synthesis in these patients have a common metabolic origin.
D000328:Adult; D000428:Alcohol Drinking; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D002914:Chylomicrons / Q000097:blood; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D004040:Dietary Carbohydrates; D005243:Feces / Q000032:analysis; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism*; D007328:Insulin / Q000627:therapeutic use; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D013256:Steroids / Q000378:metabolism; D013974:Thyroxine / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood*
D001647:Bile Acids and Salts; D002914:Chylomicrons; D004040:Dietary Carbohydrates; D007328:Insulin; D008079:Lipoproteins, VLDL; D013256:Steroids; D014280:Triglycerides; D002784:Cholesterol; D011433:Propranolol; D013974:Thyroxine; D005905:Glyburide