The effects of lithium ions on the antidiuretic action of vasopressin in the rat.
1 The effect of intravenous infusion of lithium, 2.56 mumol/min on the antidiuretic responses to antidiuretic hormone (ADH), adenosine triphosphate (ATP), 3'-5' adenosine cylic monophosphate (cyclic AMP) and theophyline was studied in water-loaded, alcohol-anaesthetized rats. 2 Lithium reversibly inhibits the antidiuretic response to all concentrations of ADH, depressing the maximum response but not changing the amount required for half maximal response. 3 The rate of increase of serum lithium relates more clearly to the inhibitory effect than does the serum concentration. 4 Sodium concentrations in the renal papilla seem to fall when serum lithium levels are rising. 5 Lithium inhibits the antidiuretic response to ATP and cyclic AMP but does not inhibit the response to theophyline.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D007668:Kidney / Q000378:metabolism; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors; D014667:Vasopressins / Q000037:antagonists & inhibitors*
D014667:Vasopressins; D000255:Adenosine Triphosphate; D008094:Lithium; D012964:Sodium; D013806:Theophylline; D000242:Cyclic AMP; D011188:Potassium