The distribution of pyrophosphatidic acid in nature.
The occurrence of a novel phospholipid, pyrophosphatidic acid, in the lipid extracts of yeasts (23 species), bacteria (E. coli), algae (chlorella), mammalia (human, rabbit, guinea pig, and mouse), insect (cockroach), fish (carp), mollusc (clam), and spermatophyta (spinach) was investigated. Pyrophosphatidic acid was found exclusively in the lipid extracts of several kinds of yeast species, but not in other normal living species (animals, plants, and microorganisms) so far investigated. All of the yeast species containing this lipid belong to the asporogenous yeasts (Cryptococcus neoformans CBS-132, Cryptococcus laurentii Z 6-5, Rhodotorula glutinis H 3-9-1, Rhodotorula rubra AY-2, Kloeckera apiculata KK-3, and Trichosporon cutaneum KC 4-3),  and ballistosporogenous yeast (Sporobolomyces salmonicolor WF 174). In contrast, no detectable amount of pyrophosphatidic acid was found in the cellular lipids of ascosporogenous yeasts.
D000818:Animals; D002855:Chromatography, Thin Layer; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D010712:Phosphatidic Acids / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis*; D010756:Phosphoric Acids / Q000032:analysis; D011817:Rabbits; D012248:Rhodotorula / Q000032:analysis; D015003:Yeasts / Q000032:analysis*
D010712:Phosphatidic Acids; D010743:Phospholipids; D010756:Phosphoric Acids