Accelerated immune complex nephritis due to mesangial overloading in spontaneous hypertensive (SHR) rats.
Immune complex nephritis induced by bovine serum albumin (BSA) and horseradish peroxidase (HRP) was superimposed upon spontaneous hypertensive rats (SHR rats) which were pretreated with polyvinyl alcohol (PVA). PVA accumulated predominantly in the mesangium, and the superimposed nephritis developed more accelerated glomerular damage with marked capillary deposition of immune complexes than control animals which were not pretreated with PVA.
D000818:Animals; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006735:Horseradish Peroxidase; D006973:Hypertension / Q000150:complications*; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007679:Kidney Medulla / Q000276:immunology*; D009393:Nephritis / Q000209:etiology* / Q000276:immunology; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D051381:Rats; D012710:Serum Albumin, Bovine
D003176:Complement C3; D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol; D006735:Horseradish Peroxidase