[Reactive metabolites of xenobiotics : their role in the hepatotoxicity of drugs].
Certain drugs are transformed into reactive metabolites by cytochrome P-450, a hepatic microsomal enzyme. The reactive metabolites covalently bind to hepatocyte macromolecules, thus determining liver lesions. Induction of microsomial enzymes increases the formation of reactive metabolites and exaggerates hepatotoxicity of these drugs.
D000082:Acetaminophen / Q000009:adverse effects / Q000378:metabolism; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D064420:Drug-Related Side Effects and Adverse Reactions; D005978:Glutathione / Q000378:metabolism; D006016:Glycolates / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D006834:Hydrazines / Q000009:adverse effects / Q000378:metabolism; D007538:Isoniazid / Q000009:adverse effects / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012293:Rifampin / Q000009:adverse effects / Q000378:metabolism
D006016:Glycolates; D006834:Hydrazines; D008996:Monoamine Oxidase Inhibitors; D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; D007538:Isoniazid; D012293:Rifampin
Les métabolites réactifs des xénobiotiques : leur rôle dans l'hépatotoxicité des médicaments.