Loss of anti-tumour immunogenicity of a somatic cell hybrid line with increasing subculture.
Good immunoprotection was afforded by A9/SEWA somatic hybrid cells in the C3H mouse/C3H Py tumour system, confirming results previously obtained in the A.SW mouse/SEWA tumour system. However, in this study the immunogenicity decreased with increasing serial subculture of the hybrid line and concomitant chromosome loss.
D000818:Animals; D002460:Cell Line; D002875:Chromosomes; D006822:Hybrid Cells / Q000276:immunology*; D007114:Immunization; D066298:In Vitro Techniques; D007621:Karyotyping; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology*; D011120:Polyomavirus