title: In vitro inhibition of human lymphocyte transformation by natural or synthetic prostaglandins.
abstract: We have examined the role of 45 natural or synthetic prostaglandins (PGs) in the in vitro responsiveness of human lymphocytes toward two different varieties of mitogenic stimuli: the mixed lymphocyte culture (MLC) and the tuberculinic test (LTT). Addition of PGs to culture of lymphocytes decreases the uptake of 3H thymidin.
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D012661:Semen / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D014374:Tuberculin Test
chemical_list: D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D013936:Thymidine