The effect of alpha1-24-corticotropin on growth hormone release in prepubertal children.
The effect of alpha1-24-corticotropin-Zn on the results of pituitary stimulation tests (moderate standardized physical exercise, arginine infusion, insulin-induced hypoglycemia) was studied in 27 prepubertal children with non-endocrine retardation of growth and development. After administration of 1 mg alpha1-24-corticotropin, the basal blood glucose and plasma cortisol levels rose significantly. However, the growth hormone increase after the three stimulation tests was significantly lower than without the corticotropin injection. The results demonstrate the inhibiting effect of alpha1-24-corticotropin on growth hormone secretion.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000367:Age Factors; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D005082:Physical Exertion; D010902:Pituitary Gland / Q000187:drug effects*; D011627:Puberty; D013268:Stimulation, Chemical
D001786:Blood Glucose; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D001120:Arginine; D006854:Hydrocortisone