Natural immunity in the oncornavirus-infected mouse.
BALB/cfC3H females neonatally infected with mammary tumor virus (MTV) possess spleen cells capable of significant cytotoxic activity against target MTV-induced mammary tumor cells in microcytotoxicity assay. Spleen cells from supposedly MTV-free BALB/c females are also specifically reactive, as a result of horizontal transmission of MTV antigens. No quantitative differences in reactivity exist between females not susceptible to the development of mammary tumors (BALB/c) and those that may develop or already have tumors (multiparous BALB/cfC3H). However, there are qualitative differences in response between those at risk and those not at risk.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000936:Antigen-Antibody Complex; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000276:immunology; D008324:Mammary Tumor Virus, Mouse; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008892:Milk / Q000382:microbiology; D012306:Risk; D013154:Spleen / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000635:transmission
D000936:Antigen-Antibody Complex