Association of mouse liver adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels with histocompatibility-2 genotype.
When the content of cyclic AMP (cAMP) was compared in livers of a series of congenic mouse strains differing at the H-2 locus, significant variation in concentration of cAMP per unit wet weight was found among strains, and also for animals of a given strain with increasing age. For a given age, from 8 to 22 weeks, cAMP levels in liver of H-2a and H-2b genotype animals were significantly higher than that in liver of H-2k type animals. This difference was seen whether the H-2 gene was on the genetic background of strain C57BL/10, C3H, or A. Levels of cAMP in livers of H-2d animals were between those of H-2a and H-2k animals.
D000375:Aging; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D008040:Genetic Linkage; D014644:Genetic Variation; D005838:Genotype; D006649:Histocompatibility Antigens; D006824:Hybridization, Genetic; D007700:Kinetics; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000378:metabolism; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism; D011955:Receptors, Drug
D006649:Histocompatibility Antigens; D011506:Proteins; D011955:Receptors, Drug; D000242:Cyclic AMP