The effect of acetylethyleneimine upon a strain of inactivated foot-and-mouth disease virus stored at 4 degrees C.
The presence of either thiosulphate-neutralized or free AEI was shown to degrade inactivated foot-and-mouth disease virus Type O (Hong Kong) antigen during storage at 4 degrees C. Deterioration was evident after 20 weeks of storage and little antigen remained at 36 weeks. Optimum stability was obtained by removing the residual inactivant immediately after inactivation.
D000818:Animals; D000956:Antigens, Viral; D005537:Aphthovirus / Q000187:drug effects* / Q000276:immunology; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002499:Centrifugation, Density Gradient; D002845:Chromatography; D003080:Cold Temperature; D004355:Drug Stability; D005536:Foot-and-Mouth Disease / Q000517:prevention & control; D006168:Guinea Pigs; D009500:Neutralization Tests; D013885:Thiosulfates / Q000494:pharmacology; D014613:Vaccines, Attenuated / Q000592:standards; D014765:Viral Vaccines / Q000592:standards
D000956:Antigens, Viral; D001388:Aziridines; D001389:Azirines; D013885:Thiosulfates; D014613:Vaccines, Attenuated; D014765:Viral Vaccines