A phylogenetic study of the role of cyclic AMP in lipid synthesis in vertebrates.
The effect of cyclic AMP on the incorporation of acetate-2-14C into sterols and fatty acid in vitro in slices of liver and intestine was examined in various representatives of the vertebrate group. In no instance was an effect on lipid synthesis noted in intestine. Cyclic AMP exerted no significant effects on hepatic lipogenesis in lower vertebrates, including the nurse shark, catfish, toad, or iguana. However, the nucleotide strongly inhibited the incorporation of acetate-2-14C into fatty acid by the chicken liver. Similar inhibition of fatty acid synthesis was also noted in rat liver, but in this mammalian species hepatic sterol synthesis was also strikingly suppressed by cyclic AMP. Interruption of the enterohepatic circuit in the rat, while enhancing rates of sterol synthesis in both liver and intestine, neither enhanced nor diminished hepatic susceptibility to suppressed sterologenesis by cyclic AMP, nor did it confer on the intestine any newfound capacity for cyclic AMP-regulated lipid synthesis.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D005075:Biological Evolution; D002024:Bufo marinus / Q000378:metabolism; D002645:Chickens / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D005399:Fishes / Q000378:metabolism; D007076:Iguanas / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D010802:Phylogeny; D051381:Rats; D012039:Regional Blood Flow; D012754:Sharks / Q000378:metabolism; D013045:Species Specificity; D014714:Vertebrates / Q000378:metabolism*
D000085:Acetates; D008055:Lipids; D002784:Cholesterol; D000242:Cyclic AMP