The effect of germfree and SPF maintenance conditions on the lifespan and diseases of small laboratory animals.
The mortality rates and spontaneous diseases defining the course of natural mortality graphs in colonies of Han: NMRI mice kept under conventional, SPF and germfree maintenance conditions are reported. A specific problem in SPF colonies is caused by ubiquitous germs. The lesions and possible reasons for such types of infections are discussed.
D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D005856:Germ-Free Life; D005921:Glomerulonephritis / Q000662:veterinary; D007938:Leukemia / Q000662:veterinary; D008017:Life Expectancy; D008321:Mammary Glands, Animal; D051379:Mice; D009026:Mortality; D009369:Neoplasms / Q000662:veterinary; D051381:Rats; D013047:Specific Pathogen-Free Organisms; D013223:Statistics as Topic