Pharmacologic interaction between cannabinol and delta9-tetrahydrocannabinol.
The pharmacological activities of delta9-THC [(minus)-delta9-trans-tetrahydrocannabinol], CBN (Cannabinol) and mixtures of delta9-THC + CBN were studied in rabbits, rats and mice. CBN, although in general less active, mimicked the effects of delta9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice. When the mixture delta9-THC + CBN was used, a synergistic effect occurred on most of the depressant effects. On the other hand CBN did not interfere with or slightly inhibited the excitatory effects of delta9-THC. In the one peripheral test used, CBN did not alter the delta9-THC effect.
D000374:Aggression / Q000187:drug effects; D000698:Analgesia; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002188:Cannabis / Q000494:pharmacology*; D002389:Catatonia / Q000139:chemically induced; D003315:Cornea / Q000502:physiology; D013759:Dronabinol / Q000494:pharmacology*; D004357:Drug Synergism; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009048:Motor Skills / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012018:Reflex / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D012892:Sleep Deprivation; D012895:Sleep, REM
D013759:Dronabinol; D010424:Pentobarbital