[Sensitivity of pathogenic clostridia to antibiotics].
By the sensitivity levels of the gas infection causative agents, i. e. pathogenic Clostridia to antibiotics, the latter were conditionally divided into 4 groups. The 1st group included the most active antibiotics, such as tetracyclines,, penicillins, cephalosporins, rifampicin, 7-chlor-7-desoxylincomycin. Their minimum inhibitory and bactericidal concentrations did not usually exceed 2 gamma/ml. For most of the strains the inhibitory and bactericidal concentrations amounted to the tenth and hundredth fractions of gamma/ml. The antibiotics of the 2nd group, i. e. erythromycin, lincomycin,ristomycin and levomycetin inhibited multiplication and viability of pathogenic Clostridia in concentrations of 20 gamma/ml. Erythromycin was most active among them The 3rd group consisted of oleandomycin, novobiocin, geliomycin and azalomycin, the minimum inhibitory concentrations of them being 20 to 50 gamma/ml. The antibiotics of the 4th group, i. e. neomycin, monomycin, kanamycin, streptomycin, polymyxin and others affected pathogenic Clostridia at very high concentrations, amounting to the hundrenth and thousandth of gamma/ml.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects*; D003016:Clostridium perfringens / Q000187:drug effects; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D008034:Lincomycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003470:Culture Media; D010406:Penicillins; D008034:Lincomycin
Ochuvstvitel'nosti patogennykh klostridiĭ k antibiotikam