title: Cyclic AMP induces ultrastructural differentiation of normal adult human adrenocortical cells cultured in vitro.
abstract: Electron microscopic studies have revealed that cyclic AMP, like ACTH, induces structural differentiation of adult human adreno-cortical cells cultured in vitro. These findings support the hypothesis that cyclic AMP can function as an intracellular mediator of the action of ACTH on the human adrenal gland.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000648:ultrastructure*; D000311:Adrenal Glands / Q000648:ultrastructure*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D001706:Biopsy; D046508:Culture Techniques; D000242:Cyclic AMP / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure
chemical_list: D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP