title: Synergism of vitamins A and E with dermatologic applications.
abstract: A synergism between vitamins A and E has been demonstrated by a number of investigators, notably Stanley R. Ames, who showed that in rats on a vitamin E deficient diet, the serum vitamin A level remained low, no matter how much vitamin A was given by mouth, or even by injection, but that adding vitamin E to the diet restored the vitamin A serum level to normal. We have utilized these observations with a high degree of success where vitamin A alone had failed to control three dermatologic conditions involving a defect in keratinization, namely, keratosis follicularis (Darier's disease), pityriasis rubra pilaris, and acne vulgaris. It is possible that a number of additional dermatoses characterized by dyskeratosis or hyperkeratosis might also be benefited by this combination.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D002648:Child; D007644:Darier Disease / Q000188:drug therapy; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D014801:Vitamin A / Q000009:adverse effects / Q000627:therapeutic use*; D014810:Vitamin E / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014801:Vitamin A; D014810:Vitamin E