Carcinogenicity of nitrosation products of ephedrine, sarcosine, folic acid, and creatinine.
Carcinogenic activity of several synthetic N-nitroso compounds was evaluated in C57BL/6J X C3HeB/FeJ F1 mice. Test substances, suspended in trioctanoin, were injected i.p. in three equal doses given on Days 1, 4, and 7 after birth and animals were held without further treatment for up to 85 weeks. Nitrosoephedrine at a total dose of 600 mg/kg induced metastasizing liver cell carcinomas in 28 of 30 animals. Nitrososarcosine (225 mg/kg) induced similar tumors in 8 of 14 animals. Nitrosofolic acid (375 mg/kg) induced lung adenocarcinomas in 4 of 28 mice. Creatinine-5-oxime (600 mg/kg) showed no evidence of carcinogenic activity. Diethylnitrosamine (12 mg/kg given in four doses), included as a positive control, caused metastasizing liver cell tumors in 23 of 25 animals.
D002759:Adenoma, Bile Duct / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced*; D003404:Creatinine / Q000031:analogs & derivatives; D004809:Ephedrine / Q000031:analogs & derivatives; D005492:Folic Acid / Q000031:analogs & derivatives; D006965:Hyperplasia / Q000139:chemically induced; D007928:Lethal Dose 50; D008113:Liver Neoplasms / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009455:Neurofibroma / Q000139:chemically induced; D009574:Nitro Compounds / Q000633:toxicity; D009603:Nitroso Compounds; D011230:Precancerous Conditions / Q000139:chemically induced; D012521:Sarcosine / Q000031:analogs & derivatives
D002273:Carcinogens; D009574:Nitro Compounds; D009603:Nitroso Compounds; D005492:Folic Acid; D003404:Creatinine; D004809:Ephedrine; D012521:Sarcosine