Two cases of penicillamine-induced pemphigus erythematosus.
2 women, 62 and 69 years old, both suffering from rheumatoid arthritis, were treated for 1 and 1 1/2 years, respectively, with penicillamine. Both developed a bullous eruption which according to clinical and histological picture, immunofluorescence studies and to light provocation, as well as in 1 case to antinuclear antibody findings corresponded to pemphigus erythematosus. In spite of treatment with prednisone and azathioprine, they still keep developing bullae.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001379:Azathioprine / Q000627:therapeutic use; D003875:Drug Eruptions / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology*
D010396:Penicillamine; D001379:Azathioprine; D011241:Prednisone