The plasmatic 11-hydroxy-corticosteroid response in the human to a synthetic octadecapeptide corticotrophin (C-41795-Ba).
The adrenal response as measured by the plasmatic changes in 11-hydroxy-corticosteroid (11-OHCS) concentration following the administration of a synthetic octadecapeptide (C-41795-Ba) was compared in 17 normal young males with that obtained with the commercially available tetracosactrin. C-41795-Ba polypeptide shows a higher potency than tetracosactrin. Its effects are longer lasting when administered intravenously which indicates a significant local inactivation of the polypeptide.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000328:Adult; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone