Attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees C.
A variant of Herpesvirus saimiri (HVS) stably attenuated for marmosets was isolated after serial passage of wild-type HVS in cell culture at 39 degrees C. Marmosets previously inoculated with attenuated virus experienced a significant delay in the development of lymphoma when challenged with wild-type HVS.
D000818:Animals; D000917:Antibody Formation; D002143:Callitrichinae / Q000276:immunology*; D002478:Cells, Cultured; D006564:Herpesviridae / Q000276:immunology*; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology*; D006358:Hot Temperature; D008223:Lymphoma / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
D014613:Vaccines, Attenuated; D014765:Viral Vaccines