Cyclic AMP induces ultrastructural differentiation of normal adult human adrenocortical cells cultured in vitro.
Electron microscopic studies have revealed that cyclic AMP, like ACTH, induces structural differentiation of adult human adreno-cortical cells cultured in vitro. These findings support the hypothesis that cyclic AMP can function as an intracellular mediator of the action of ACTH on the human adrenal gland.
D000302:Adrenal Cortex / Q000187:drug effects / Q000648:ultrastructure*; D000311:Adrenal Glands / Q000648:ultrastructure*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D001706:Biopsy; D046508:Culture Techniques; D000242:Cyclic AMP / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure
D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP