[Change in the glycolytic and glucose-6-phosphate dehydrogenase activity in experimental cirrhosis of the liver].
Development of cirrhosis of liver tissue did not influence the intensity of glycolysis, with glucose as a substrate, in supernatant fraction of liver homogenate in chronic intoxication with CCL4. In preparations of cirrhotic liver, as compared with liver from the intact animals, more distinct activation of glycolysis was caused by addition of ATP and NAD at the stage of 3-week intoxication and also by addition of hexokinase, glyceraldehydephosphate dehydrogenase and lactate dehydrogenase at the stage of distinct cirrhosis of liver (6 weeks of CCL4 intoxication). Km values for glucose-6-phosphate dehydrogenase increased over all the periods of intoxication.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D002908:Chronic Disease; D004789:Enzyme Activation / Q000187:drug effects; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D005993:Glycerolphosphate Dehydrogenase / Q000494:pharmacology; D006019:Glycolysis / Q000187:drug effects; D006593:Hexokinase / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D009243:NAD / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D009243:NAD; D000255:Adenosine Triphosphate; D005993:Glycerolphosphate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase
Izmenenie aktivnosti glikoliza i gliukozo-6-fosfatdegidrogenazy pri éksperimental'nom tsirroze pecheni