title: Effect of pyrantel tartrate and carbadox on acquisition of the swine kidneyworm (Stephanurus dentatus) and other parasites by pigs on contaminated lots.
abstract: A combination of pyrantel tartrate (106 mg/kg of body weight) and carbadox (55 mg/kg of body weight) in ground feed was fed to 20 weaned pigs (av wt, 14.4 kg) for 42 days. Another group of 20 pigs included nontreated controls. The pigs were farrowed and suckled in a slat-floored farrowing house and had minimal exposure to the small intestinal threadworm (Stronglyoides ransomi) until they were placed on severely contaminated dirt lots at the start of the experiment. Five pigs from each of the two groups were necropsied on day 42. Carbadox was withheld from the feed for the 15 remaining treated pigs. All other pigs were necropsied when they attained market weight, 72 to 83 days layer. Treated pigs killed at market weight had 44% fewer (P less than 0.10) kidneyworms (Stephanurus dentatus) than did control pigs. A 17% increase (P less than 0.01) in the weights of livers of control pigs when compared with treated market-weight pigs was associated with an increase of fibrotic hepatic tissue of control pigs. Worm infections were reduced in the treated market-weight pigs: by 96% (P less than 0.05) for the large roundworm (Ascaris suum), 77% (P less than 0.01) for nodular worms (Oesophagostomum spp), and 64% (P less than 0.01) for the intestinal threadworm. There was some evidence for prophylaxis in market-weight pigs (P less than 0.10) against lungworms (Metastrongylus spp), but none against the whipworm (Trichuris suis) or thick stomach worms (Ascarops strongylina and Physocephalus sexalatus). Pigs given the pyrantel tartrate in feed until attaining market weight maintained a feed-to-gain ratio superior (7.1%) to that of nontreated pigs.
mesh_terms: D000818:Animals; D002218:Carbadox / Q000627:therapeutic use*; D009349:Nematode Infections / Q000517:prevention & control / Q000662:veterinary*; D011715:Pyrantel / Q000031:analogs & derivatives*; D011717:Pyrantel Tartrate / Q000627:therapeutic use*; D011810:Quinoxalines / Q000627:therapeutic use*; D017206:Strongylida Infections / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*
chemical_list: D011810:Quinoxalines; D011715:Pyrantel; D002218:Carbadox; D011717:Pyrantel Tartrate