title: Effects of carbohydrate-active steroids and ACTH on visually-evoked responses in patients with adrenal cortical insufficiency.
abstract: Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were of small amplitude and short latency. Treatment with ACTH alone decreased the amplitude-intensity response, suggesting extra-adrenal effects. Both with amplitude and latency effects, stimulus intensity was an important parameter in determining steroid and ACTH effects.
mesh_terms: D000293:Adolescent; D000303:Adrenal Cortex Diseases / Q000503:physiopathology*; D000307:Adrenal Gland Diseases / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000328:Adult; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone