Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization.
Septamycin is a metal complexing polyether antibiotic produced by a strain of Streptomyces hygroscopicus NRRL 5678. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C48H81NaO16. The crystal structure and absolute configuration were established by X-ray analysis of the p-bromophenacyl derivative. Septamycin has a thirty-carbon backbone and contains seven heterocyclic rings. Supported by direct comparison septamycin proved to be identical with antibiotic A28695 A isolated from Streptomyces albus NRRL 3883. The metabolite is active against gram-positive bacteria and Eimeria tenella (chicken coccidiosis).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D004285:Dogs; D004987:Ethers / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D009522:Newcastle disease virus / Q000187:drug effects; D011201:Poultry Diseases / Q000188:drug therapy; D051381:Rats; D018139:Simplexvirus / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004987:Ethers