[Alterations in the secretory glandulocytes of the stomach in the presence of an imbalance in adrenal cortex and thyroid gland hormones].
Gastric secretory granulocytes in Wistar rats were studied electron microscopically and microspectrophotometrically. Injection of L-thyroxin for 10--30 days resulted in decrease of acid phosphatase and ATPh-ase activity in the main and parietal granulocytes. Injection of hydrocortisone after or simultaneously with saturation of the organism with L-thyroxin results in increasing acid phosphatase activity of these cells. After simultaneous prolonged injection of these two hormones, the number of lysosomes increased in parietal glandulocytes and mitochondrial membranes were destroyed in the main and parietal glandulocytes. Together with these phenomena, changes in the activity of oxidative-reductive enzymes were observed, demonstrating a sharp decrease of energetic importance of the main oxidation way in Krebs cycle.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D006651:Histocytochemistry; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*
D010088:Oxidoreductases; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D013974:Thyroxine; D006854:Hydrocortisone
Izmeneniia sekretornykh glandulotsitov zheludka pri disbalanse gormonov kory nadpochechnika i shchitovidnoĭ zhelezy.