Additional pharmacological aspects of orgotein, a metalloprotein with superoxide-dismutase activity.
Orgotein is a copper- and zinc-containing protein with superoxide-dismutase activity which can be isolated from bovine liver and erythrocytes. The effects of this drug on adjuvant -induced arthritis in rats, and particularly on the changes in erythrocytes sedimentation rates and plasma fibrinogen levels induced by this experimental infection, were studied. Orgotein was also assayed on nystatin-induced paw edema, passive cutaneous anaphylaxis and Arthus reaction, in rats. Finally, studies on platelet aggregation and the prostaglandin system were conducted. Given at doses of 2.5 and 5 mg/kg i.p. for 14 days to arthritic rats, orgotein normalized the serum changes, inhibited the foot swelling and improved the performance time on the rotating bar. The drug reduced, after a single dose, the nystatin-induced edema, whilst it showed no effects on the immunological inflammations, platelet aggregation and prostaglandin system. The probable mechanism of action is discussed.
D000818:Animals; D001169:Arthritis, Experimental / Q000503:physiopathology; D001183:Arthus Reaction / Q000503:physiopathology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004487:Edema / Q000503:physiopathology; D011464:Epoprostenol / Q000378:metabolism; D004912:Erythrocytes / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D008667:Metalloproteins / Q000302:isolation & purification / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011454:Prostaglandins A / Q000494:pharmacology; D051381:Rats; D013482:Superoxide Dismutase
D008667:Metalloproteins; D011454:Prostaglandins A; D011464:Epoprostenol; D013482:Superoxide Dismutase