Rat hepatoma cells nucleolar DNA. II. A possible model of nucleolar DNA organisation.
A model of nucleolar DNA organization has been established. Three clearly defined main components are found in ascites hepatoma cell nucleolar DNA by CsCl gradient analysis. A linear arrangement for nucleolar DNA and a model of DNA organization in the neighbourhood of a set of ribosomal genes, which may play a fundamental role in the elaboration of nucleolar chromatin tertiary structure, are presented.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000032:analysis*; D002466:Cell Nucleolus / Q000032:analysis* / Q000648:ultrastructure; D002499:Centrifugation, Density Gradient; D002843:Chromatin / Q000032:analysis / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis; D005796:Genes; D008113:Liver Neoplasms; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000032:analysis; D009690:Nucleic Acid Conformation; D051381:Rats; D012270:Ribosomes / Q000032:analysis
D002843:Chromatin; D004273:DNA, Neoplasm