Glycerokinase activity and lipolysis regulation in brown adipose tissue of cold acclimated rats.
Glycerol release by brown adipocytes from constant cold adapted rats was not stimulated by norepinephrine. On the contrary, the release was stimulated in rats adapted to a nycthemeral fluctuatiing temperature from 5 degrees to 28 degrees C. Glycerokinase activity was greatly increased in brown adipose tissue by cold adptation ; there was no change in the liver. However this increased activity cannot entirely explain the lack of norepinephrine stimulation of glycerol release in the brown adipose tissue of cold adapted rats.
D000064:Acclimatization; D000273:Adipose Tissue / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D005991:Glycerol Kinase / Q000378:metabolism*; D008053:Lipid Mobilization / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D010770:Phosphotransferases; D005991:Glycerol Kinase; D009638:Norepinephrine