Origin of trisomies in human spontaneous abortions.
Chromosome heteromorphisms of 34 trisomic abortuses and their parents were compared to determine the origin of the extra chromosome. Fourteen of the trisomies were maternal in origin, ten resulting from a first-meiotic-division error and four from either first- or second-meiotic-division errors. No paternally derived trisomy was identified.
D000022:Abortion, Spontaneous / Q000235:genetics*; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006801:Humans; D008423:Maternal Age; D008540:Meiosis; D011247:Pregnancy; D014314:Trisomy