Myeloid bodies formation in triparanol treated cultured cells.
Cultured cells (chicken embryo liver cells and rat embryo fibroblasts) were treated with triparanol (MER-29) for various lengths of time. Both types of cells have developed numerous membranous whorls-myeloid bodies in the cytoplasm. Various stages in myeloid bodies development are described. Acid phosphatase activity was cytochemically demonstrated within the myeloid bodies, indicating their lysosmal nature. This activity appeared only at a late stage of the myeloid bodies formation.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D002479:Inclusion Bodies / Q000201:enzymology / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects*; D008247:Lysosomes / Q000201:enzymology / Q000648:ultrastructure; D051381:Rats; D014308:Triparanol / Q000494:pharmacology*
D014308:Triparanol; D000135:Acid Phosphatase