Altered DNA synthesis in a mutant of Salmonella typhimurium that channels bacteriophage P22 toward lysogeny.
Pox-1, a mutant of Salmonella typhimurium, strongly channels P22 toward lysogeny. Viral DNA synthesis in this slow-growing mutant is delayed to a greater extent than viral protein synthesis. The relative enhancement of c2 repressor synthesis results in much higher repressor/DNA synthesis ratios in Pox-1 than in wild-type cells. This probably accounts for the high frequency of lysogenization.
D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D005809:Genes, Regulator; D008242:Lysogeny; D009154:Mutation; D011113:Polymyxins / Q000494:pharmacology; D012483:Salmonella Phages / Q000254:growth & development* / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects / Q000378:metabolism*; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
D004269:DNA, Bacterial; D004279:DNA, Viral; D011113:Polymyxins; D014764:Viral Proteins