title: Rapid determination of oxidation state of unbound 99mTc and labeling yield in 99mTc-labeled radiopharmaceuticals.
abstract: Current techniques for determining the radiochemical purity of 99mTc-labeled radiopharmaceuticals are limited by the variety of compounds that can be tested or the length of time required to complete the test. A chromatographic method, based on the use of two solvents (0.9% saline and acetone) and a stationary phase made of silica-coated cellulose strips, solves these problems for water-soluble 99mTc-labeled radiopharmaceuticals. With this method, the oxidation state of unbound 99mTc and the labeling yield of 99mTc-labeled radiopharmaceuticals can be quickly determined: the whole procedure takes only a few minutes to run. This system compares favorably with lengthier procedures and with a commercially available kit.
mesh_terms: D002845:Chromatography / Q000379:methods; D011756:Diphosphates; D007553:Isotope Labeling; D004369:Pentetic Acid; D011786:Quality Control; D013667:Technetium
chemical_list: D011756:Diphosphates; D013667:Technetium; D004369:Pentetic Acid