Neoplasms in strains of splenectomized mice after a single 7,12-dimethylbenz[alpha]anthracene treatment.
The effects of splenectomy on carcinogenesis by a single 10-mg dose of 7,12-dimethylbenz[alpha]anthracene (DMBA) given in olive oil by gavage was tested on BTOs, C57BL/60s, C3H/HeOs, and BALB/cOs mice. The splenectomy, performed a week before the DMBA was given, did not affect physical status or the incidence of acute toxic death of animals. DMBA-treated animals developed neoplasms at a significantly higher rate than did untreated mice. Splenectomy did not influence the overall incidence of neoplasms. Observed tumors in DMBA-treated groups were those of skin, forestomach, colon, liver, lung, adrenal, ovary, breast, hematopoietic-lymphoreticular system, and vascular system, depending on the strain. Types of DMBA-treated neoplasms were affected by prior splenectomy, depending on the strain: Splenectomy inhibited lung adenomas in BALB/cOs females and hepatomas in C57BL/60s females; splenectomy enhanced skin neoplasms in C57BL/60s and squamous cell carcinoma of the forestomach in BTOs males. The most significant change was in the incidence of the group of lymphomas. Myelogenous leukemia was increased in DMBA-treated groups of all strains, but splenectomy inhibited the development of this type of lymphoma.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000506:poisoning; D000236:Adenoma / Q000139:chemically induced; D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000686:Amyloidosis / Q000139:chemically induced; D000818:Animals; D001551:Benz(a)Anthracenes; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000139:chemically induced; D005260:Female; D006391:Hemangioma / Q000139:chemically induced; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced / Q000473:pathology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced; D013154:Spleen / Q000502:physiology*; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000139:chemically induced
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene