Donor specific suppressor cells in association with rejection of a renal allograft.
Details are presented of three aspects of immunological monitoring in a single instance of severe irreversible rejection of a renal allograft. Rejection is associated with strong evidence of lymphocyte mediated cytotoxicity (LMC). During this period reduced responsiveness of recipient cells to stimulation in vitro by donor cells is observed; this is more reduced than is responsiveness to random cells. Donor-specific suppressor cells also develop, as detected in two systems. It is postulated that the data are evidence that competition exists between different agressive and suppressive subpopulation of recipient lymphocytes.
D000700:Analgesics / Q000009:adverse effects; D003602:Cytotoxicity, Immunologic; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007108:Immune Tolerance; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000276:immunology; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000145:classification; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014184:Transplantation, Homologous
D000700:Analgesics