Comparisons of antidotal efficacy of chelating drugs upon acute toxicity of Ni(II) in rats.
Six chelating drugs were administered to rats by im injection at equimolar dosages in order to compare their relative effectiveness in prevention of death after a single parenteral injection of NiCl2. Triethylenetetramine and d-penicillamine were most effective antidotes for acute Ni (II)-toxicity. In order of decreasing antidotal effectiveness, diglycyl-L-histidine-N-methylamide, sodium diethyldithiocarbamate and calcium disodium versenate significantly reduced the acute mortality of rats following ip injection of Ni (II). Alpha-Lipoic acid was not effective as an antidote for acute Ni (II)-toxicity.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use*; D004050:Ditiocarb / Q000627:therapeutic use; D004492:Edetic Acid / Q000627:therapeutic use; D005029:Ethylenediamines / Q000627:therapeutic use; D005260:Female; D007928:Lethal Dose 50; D009532:Nickel / Q000506:poisoning* / Q000633:toxicity; D009842:Oligopeptides / Q000627:therapeutic use; D010396:Penicillamine / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D008063:Thioctic Acid / Q000627:therapeutic use
D000931:Antidotes; D002614:Chelating Agents; D005029:Ethylenediamines; D009842:Oligopeptides; C012285:diglycyl-histidine-N-methylamide; D008063:Thioctic Acid; D009532:Nickel; D004050:Ditiocarb; D004492:Edetic Acid; D010396:Penicillamine