Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.
The investigation of 400 adult mice had the objective to find out 1. The influence of splenectomy on genesis and growth of a benzpyrene-induced sarcoma and 2. The behavior of B- and T-lymphocytes under the influence of splenectomy.


RESULTS
1. A significantly lower number of tumors developed in splenectomized animals (28.5%) as compared to controls (49.5%). 2. A significant decrease of B-lymphocytes and an increase in T cells after splenectomy were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a decreased number of B-lymphocytes and an increase of T-lymphocytes, while the total count of round cells remained unchanged. These results are discussed and compared with results of other authors.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001580:Benzopyrenes; D005260:Female; D051379:Mice; D009217:Myosarcoma / Q000276:immunology / Q000473:pathology; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology; D013156:Splenectomy; D013601:T-Lymphocytes / Q000276:immunology*
D001580:Benzopyrenes