title: Comparison of the acute toxicity of clioquinol, histamine, and chloroform in different strains of mice.
abstract: The oral LD50'S of clioquinol, histamine and chloroform and the intravenous LD50 of histamine were determined separately in male and female mice of the Tif : MAGf (SPF), Tif : MF2f (SPF), C3H/Tif Bomf, DBA2/J Bomf, C57Bl/6J/Bomf and A/J Bomf strains. Mice of the Tif : MAGf (SPF) outbred strain and the Tif : MF2f(SPF) hybrids tended to be more resistant than the inbred strains, with exception of C57Bl/6J/Bomf, which proved least susceptible to the lethal effects of the tested preparations. The toxicity of chloroform was more pronounced in the males than in the females, and C3H/Tif Bomf proved more susceptible than all other strains. The toxicity of clioquinol and histamine was not related to sex.
mesh_terms: D000818:Animals; D002725:Chloroform / Q000633:toxicity*; D007464:Clioquinol / Q000633:toxicity*; D005260:Female; D006632:Histamine / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D013045:Species Specificity
chemical_list: D007464:Clioquinol; D002725:Chloroform; D006632:Histamine