title: Neurohormonal control of gonadotropic secretion in primates.
abstract: With immunohistochemical techniques, products from both the parvicellular system (such as Gn-RH) and from the magnocellular system (vasopressin, oxytocin, and neurophysins) have been shown to be present in the neurons ending around the hypothalamopituitary portal capillary system. A neurosurgical technique for prolonged collection of pituitary stalk blood has been developed. Gn-RH, vasopressin, and neurophysins have been found in large amounts in pituitary stalk blood. Gn-RH levels were found to vary in a pulsatile fashion, thereby providing direct evidence for hypothalamic modulation of the discharge of LH by the pituitary. The finding of large amounts of estrogen-neurophysin in portal vein blood adds further evidence to the hypothesis that "estrogen" neurophysin may play a role in the control by the hypothalamus over the secretion of gonadotropins.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002369:Castration; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D007031:Hypothalamus / Q000502:physiology; D007986:Luteinizing Hormone / Q000378:metabolism; D009481:Neurophysins / Q000097:blood / Q000502:physiology; D010121:Oxytocin / Q000502:physiology; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D010909:Pituitary Hormones, Posterior / Q000502:physiology*; D011168:Portal System; D011323:Primates; D014667:Vasopressins / Q000097:blood / Q000502:physiology
chemical_list: D006065:Gonadotropins, Pituitary; D009481:Neurophysins; D010909:Pituitary Hormones, Posterior; D014667:Vasopressins; D007987:Gonadotropin-Releasing Hormone; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone