Selective inhibition of nicotinamide adenine dinucleotide dependent oxidations by substituted carbamides.
Several 1-substituted acetyl-3-aryl carbamides selectively inhibited nicotinamide adenine dinucleotide (NAD) dependent oxidation of alpha-keotoglutarate and beta-hydroxybutyrate by rat brain homogenates. NAD-independent oxidation of succinate remained unaltered. The inhibition observed with 1-(N-acetylmorpholino)-3-(4-methylphenyl)carbamide was competitive in nature.
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000648:ultrastructure; D006885:Hydroxybutyrates / Q000378:metabolism; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009243:NAD / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D010084:Oxidation-Reduction; D051381:Rats
D000577:Amides; D006885:Hydroxybutyrates; D007656:Ketoglutaric Acids; D009243:NAD; D009247:NADH, NADPH Oxidoreductases