Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats.
Tranylcypromine (TCP), a monoamine oxidase inhibitor, caused a fatal hyperpyrexia in rats pretreated with LiCl once a day for 4 days. Pretreatment with LiCl alone did not alter the level of serotonin (5-HT), dopamine (DA) and norepinephrine (NE) in the brain. In fatal hyperpyrexia caused by LiCl plus TCP, the brain 5-HT and DA levels were increased, whereas the brain NE level was decreased. Reserpine and alpha-methyl-p-tyrosine completely prevented the hyperpyrexia, but FLA-63 did not show any effect. The hyperpyrexia was completely prevented by p-chlorophenylalanine (PCPA) given 72 hours before TCP but not by PCPA given 24 hours before TCP. Haloperidol and chlorpromazine, DA receptor blockers, inhibited the fatal hyperpyrexia, while cyproheptadine and methysergide, 5-HT receptor blockers, did not. These results suggest that DA plays an essential role in the hyperpyrexia induced by the combination of TCP and LiCl in rats, but the involvement of 5-HT is inconclusive.
D000588:Amines / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry; D002746:Chlorpromazine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D010134:Fenclonine / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced* / Q000517:prevention & control; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D014191:Tranylcypromine / Q000008:administration & dosage / Q000494:pharmacology
D000588:Amines; D008781:Methyltyrosines; D003533:Cyproheptadine; D014191:Tranylcypromine; D012110:Reserpine; D008094:Lithium; D010134:Fenclonine; D002746:Chlorpromazine; D004298:Dopamine