[Changes in leukocyte enzyme activity during experimental amyloidogenesis and in patients with amyloidosis].
The activity of hydrolytic and redox myeloperoxidase enzymes was determined in the neutrophils and lymphocytes of the peripheral blood of patients with secondary amyloidosis and also of the animals with amyloidogenesis and amyloidosis (caseine model). During the amyloidogenesis the activity of hyocrolytic enzymes and of myeloperoxidase in the neutrophils was found to decrease; this was particularly marked at the stage of the initial amyloid deposition. Changes in the enzyme activity in the animals against the background of already developed amyloidosis coincided with such in the blood cells of patients with secondary amyloidosis. The results obtained are discussed from the aspects of resorption theory.
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000682:Amyloid / Q000096:biosynthesis*; D000686:Amyloidosis / Q000201:enzymology*; D000818:Animals; D002682:Chinchilla; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology*; D008214:Lymphocytes / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000682:Amyloid; D005993:Glycerolphosphate Dehydrogenase; D009195:Peroxidase; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Izmenenie aktivnosti fermentov leĭkotsitov v protsesse amiloidogeneza v éksperimente i u bol'nykh amiloidozom