Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells.
Cells derived from tumors induced in "nude" mice after injection of cells that were hybrids between mouse peritoneal macrophages and simian virus 40 (SV40)-transformed human cells were found to retain the human chromosome 7 carrying the SV40 genome, and indicate that the presence of human chromosome 7 carrying the SV40 genome is responsible for the expression of the tumorigenic phenotype in the hybrid cells.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002906:Chromosomes, Human, 6-12 and X / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D005347:Fibroblasts / Q000032:analysis; D006801:Humans; D006822:Hybrid Cells / Q000032:analysis*; D007621:Karyotyping; D007926:Lesch-Nyhan Syndrome; D008264:Macrophages; D051379:Mice; D008810:Mice, Inbred C57BL; D013539:Simian virus 40 / Q000032:analysis*
D004279:DNA, Viral