[Study of the interaction of human serum albumin with penicillins by means of spin labels].
Interaction of 8 penicillin preparations with human serum albumin was studied with the spin-labels method and a probe. Correlation between the binding level of penicillins with human serum albumin and their effect on the spectrum of EPR of the spin-label attached to albumin was observed only with the use of a hydrophobic probe (radical III). The covalent attached marks and the hydrophobic probe may be used for rapid orienting estimation of pencillin interaction with albumin.
D000667:Ampicillin / Q000494:pharmacology; D003023:Cloxacillin / Q000494:pharmacology; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D008968:Molecular Conformation; D009254:Nafcillin / Q000494:pharmacology; D010068:Oxacillin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D010404:Penicillin V / Q000031:analogs & derivatives / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000494:pharmacology*; D013053:Spectrophotometry; D013113:Spin Labels
D010406:Penicillins; D012709:Serum Albumin; D013113:Spin Labels; D009254:Nafcillin; D000667:Ampicillin; D003023:Cloxacillin; D010400:Penicillin G; D008712:Methicillin; D010068:Oxacillin; D010404:Penicillin V
Issledovanie vazimodeĭstviia syvorotochnogo al'bumina cheloveka s penitsillinami metodom spinovykh metok