[Effect of the central cholinolytic, cyclosil, on the ultrastructure and functional characteristics of rat liver mitochondria].
The influence of central cholinolytic cyclosil on the oxidative phosphorilation, ATPase activity and ultrastructure of hepatic mitochondria has been studied. The increased effectivity of mitochondrial macroergic compounds formation in the presence of cyclosil (0.04 mg/ml) was noticed. The oxygen consumption rate of these particles did not change. These findings and the electron microscopic observations on mitochondrial swelling in the presence of the cholinolytic agent suggest that cyclosil enchances the degree of mitochondrial energization.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003517:Cyclopentanes / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats
D003517:Cyclopentanes; D010276:Parasympatholytics; D010627:Phenethylamines; C016331:cyclosil; D000251:Adenosine Triphosphatases
Vliianie tsentral'nogo kholinolitika tsiklozila na ul'trastrukturu i nekotorye funktsional'nye kharakteristiki mitokhondriĭ pecheni krys.