Fructose-1,6-bisphosphatase from young and adult rats.
Fructose-1,6-bisphosphatase (E.C. 3.1.3.11) was purified from the livers of young (69-86 days) and adult (370-386 days) Fisher rats. The enzyme preparations were examined for increasing amounts of missynthesized proteins by means of heat-inactivation as well as for differences in regulatory properties. No significant difference with respect to the fraction of rapidly heat-inactivated enzyme or Km- and Ki-values was found. These results do not support the hypothesis that error accumulation resulting in an error catastrophe is a general phenomenon underlying senescence and death.
D000375:Aging; D000818:Animals; D006597:Fructose-Bisphosphatase / Q000502:physiology*; D007700:Kinetics; D008297:Male; D051381:Rats
D006597:Fructose-Bisphosphatase