The formation of deoxycholic acid in patients with type II and IV hyperlipoproteinaemia.
The formation of deoxycholic acid (D) was studied in 8 patients with Type II hyperlipoproteinaemia and in 6 with Type IV hyperlipoproteinaemia, using orally administered [2.4--3H]cholic acid and [24--14C]deoxycholic acid. The diet was standardized and of natural type. The mean values for fractional turnover, pool size and D synthesis in the patients with Type II pattern were 0.23 days-1, 331 mg and 75 mg/day, respectively; in Type IV they were 0.39 days-1, 587 mg and 191 mg/day. Compared with a group of healthy subjects, the pool size and formation of D were normal in Type IV, but significantly reduced in Type II. The mean conversion of cholic acid into the circulating pool of D was calculated to be 37% in Type II, and 38% in Type IV patients. Both these values are within normal limits.
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D002793:Cholic Acids / Q000096:biosynthesis / Q000378:metabolism; D003840:Deoxycholic Acid / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D006949:Hyperlipidemias / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001647:Bile Acids and Salts; D002793:Cholic Acids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D003840:Deoxycholic Acid