Depressed in vitro aggregation of platelets of chronic hemodialysis patients (CHDP): a role for cyclic AMP.
1) On log-log-coordiantes a direct correlation has bee shown to exist between plasma cyclic AMP and plasma Cr levels. 2) hemodialysis results in a significant reduction in the arterial plasma cyclic AMP levels, but a return of plasma cyclic AMP to pre-dialysis levels is seen within 30 mins post-dialysis. 3) the dialyzer clearance of cyclic AMP, both in vitro and vivo, is commensurate with its M.W. 4) In vitro platelet aggregation responses, to ADP, EPI, and COLL are not influenced by PRP cell counts between 150,000 and 300,000/mm3. 5) the BT of NC and CHDP are not significantly different, indicating that the in vivo hemostatic properties of the CHDP are otherwise intact. 6)the CHDP have PVPC significantly lower than the NC, a finding commensurate with the usual mold thrombocytopenia of renal failure. 7)the aggreation responses of the CHDP to COLL and to both Lo and Hi concentrations of ADP and EPI are significantly less than those of the NC. 8)A statistically significant inverse correlation between aggregation response and plasma cyclic AMP is observed.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001772:Blood Cell Count; D001777:Blood Coagulation; D001792:Blood Platelets; D003094:Collagen / Q000494:pharmacology; D003404:Creatinine / Q000097:blood; D000242:Cyclic AMP / Q000097:blood* / Q000494:pharmacology / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation / Q000187:drug effects; D006435:Renal Dialysis; D013997:Time Factors
D000244:Adenosine Diphosphate; D003094:Collagen; D003404:Creatinine; D000242:Cyclic AMP; D004837:Epinephrine