Plasma corticotrophin levels in addison-schilder's disease.
Raised plasma immunoreactive corticotrophin (ACTH) levels were found in five boys with the sex-linked disorder progressive leucodystrophy associated with adrenal insufficiency (Addison-Schilder's disease) and in a symptom-free brother of one of them. Similar ACTH concentrations were found using two antisera, one against the N-terminal part of the ACTH molecule and the other against the C-terminal part. In one patient the circulating ACTH had normal biological activity as measured using the cytochemical ACTH bioassay. Immunoreactive beta/-melanocyte-stimulating hormone was also determined in one patient and found to be raised.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000224:Addison Disease / Q000097:blood* / Q000652:urine; D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003366:Cosyntropin; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000097:blood* / Q000652:urine; D006801:Humans; D007106:Immune Sera; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000097:blood; D012737:Sex Factors
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D007106:Immune Sera; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones