Experimental parainfluenza type 1 virus-induced encephalomyelopathy in adult mouse: a histopathological study.
The pathogenicity of a strain of parainfluenza type 1 virus, isolated from the cultured brain cells from multiple sclerosis patients and designated as 6/94 virus, was studied in mouse brain. Selective degeneration of cerebral white matter, preceded by mononuclear cell infiltration, and ependymitis were prominent pathological features of the mouse intracerebrally inoculated with 6/94 virus. After inactivation by ultraviolet light the virus was still capable of producing the inflammatory and degenerative white matter lesions, although the severity of ependymitis was substantially reduced.
D000818:Animals; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases; D004195:Disease Models, Animal; D004679:Encephalomyelitis / Q000382:microbiology / Q000473:pathology; D004805:Ependyma / Q000473:pathology; D007249:Inflammation; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D009410:Nerve Degeneration; D010222:Parainfluenza Virus 1, Human / Q000472:pathogenicity* / Q000528:radiation effects; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors; D014466:Ultraviolet Rays