Interaction of glucocorticoid and insulin in the responses of rats to starvation-refeeding.
Experiments designed to determine whether the role of glucocorticoid (GC) in the induction of the enzyme overshoot response to starvation-refeeding was direct or permissive through insulin were conducted. Intact, adrenalectomized (ADX), and streptozotocin (STREP) treated rats with or without insulin and/or GC replacements were starved for 48 hours and refed a 65% glucose diet for 48 hours. The typical enzyme overshoot response to starvation-refeeding was observed in the intact rats, ADX rats given GC, STREP rats given insulin and ADX-STREP rats given glucocorticoid plus insulin. No overshoot was observed if glucocorticoid was absent whereas a modest increase in enzyme activity could be observed in insulin deficient rats treated with GC.
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D005502:Food; D005938:Glucocorticoids / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D013217:Starvation / Q000378:metabolism*; D013311:Streptozocin / Q000494:pharmacology
D005938:Glucocorticoids; D007328:Insulin; D013311:Streptozocin; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase