Immunization of Rous sarcoma virus-inoculated marmosets with BCG and transformed allogeneic cells.
The effects of specific immunotherapy with allogeneic cells transformed by Schmidt-Ruppin Rous sarcoma virus (SR-RSV), of treatment with BCG, and of surgery on the growth of SR-RSV-induced sarcomas in white-lipped marmosets were studied. Tumor incidence, tumor progression, and survival did not differ between control and treated animals. Animals immunized with BCG developed lymphocyte reactivity to tuberculin, which remained until the animals died. BCG was isolated from the spleen of one tumor-bearing animal.
D000818:Animals; D001358:Avian Sarcoma Viruses; D001500:BCG Vaccine / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D000882:Haplorhini; D007111:Immunity, Cellular; D007167:Immunotherapy; D012513:Sarcoma, Experimental / Q000209:etiology / Q000628:therapy*; D014374:Tuberculin Test
D001500:BCG Vaccine