title: Soft tissue response to four dense ceramic materials and two clinically used biomaterials.
abstract: Disk-shaped implants of spinel, alumina, mullite, zircon, a cast Co-Cr-Mo alloy, and ultra-high molecular weight polyethylene (UHMWPE), were implanted in the paraspinalis muscle of 12 adult, male, white New Zealand rabbits. Prior to implantation the implants were characterized with respect to size and shape, weight and surface roughness. After periods of 1 month, 2 months, and 4 months, the rabbits were sacrificed and the tissue specimens were retrieved with the implants still intact. Histological examination of the tissues surrounding the implants along with changes in the size and shape, weight, and surface roughness of the implants were used as criteria for evaluating these materials for implant purposes. No surfaces degradation of any of the materials was detected using scanning electron microscopy. Fibrous tissue seemed to adhere to the UHMWPE implants more than any other material used in this study. Large amounts of fibrous tissue were also found to adhere to the cast Co-Cr-Mo alloy implants. The histological results indicated that within the limits of this investigation, the biocompatibility of the ceramic materials used in this study compared favorably with the clinically used Co-Cr-Mo alloy implants and the UHMWPE implants.
mesh_terms: D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000032:analysis / Q000494:pharmacology*; D002516:Ceramics / Q000032:analysis; D002858:Chromium Alloys / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008855:Microscopy, Electron, Scanning; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects / Q000601:surgery; D011095:Polyethylenes / Q000494:pharmacology; D011817:Rabbits; D012822:Silicon Dioxide / Q000494:pharmacology; D013499:Surface Properties; D015040:Zirconium / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D002858:Chromium Alloys; D011095:Polyethylenes; D012822:Silicon Dioxide; D015040:Zirconium; D000535:Aluminum; D008274:Magnesium