[Free-Wilson analysis of the inhibitory effect of 4-substituted benzamidines on thrombin, plasmin and trypsin (author's transl)].
Using the Fujita-Ban model, the authors studied the quantitative structure-inhibitory activity relationships of a series of 4-amidinophenyl compounds with regard to thrombin, plasmin and trypsin. A satisfactory specification of the inhibitory activities was obtained from activity increments of molecular segments.
D000578:Amidines / Q000494:pharmacology*; D001550:Benzamidines / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*; D014361:Trypsin Inhibitors
D000578:Amidines; D001550:Benzamidines; D014361:Trypsin Inhibitors; D013917:Thrombin; D005341:Fibrinolysin
Free-Wilson-Analyse der Hemmwirkung von 4-substituierten Benzamidinen gegenüber Thrombin, Plasmin und Trypsin.