Regulation of bacterial motility by cyclic nucleotides and effect of biogenic amines.
When assayed by a newly devised, simple and quantitative method, "motilometry", the motility of E. coli S-26 was found stimulated by cyclic adenosine 3':5'-monophosphate (cyclic AMP) and 8-hydroxy cyclic AMP as well as histamine, catecholamines and inhibited by cyclic guanosine 3':5'-monophosphate (cyclic GMP). The stimulation elicited by cyclic AMP or other biogenic amines was reversed by cyclic GMP. The experimental significance and implicaton of these findings are discussed.
D000241:Adenosine / Q000494:pharmacology; D001679:Biogenic Amines / Q000494:pharmacology*; D003994:Bucladesine / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D007700:Kinetics; D010208:Papaverine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012265:Ribonucleotides / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology
D001679:Biogenic Amines; D012265:Ribonucleotides; D013096:Spermine; D003994:Bucladesine; D006632:Histamine; D012110:Reserpine; D010208:Papaverine; D000242:Cyclic AMP; D006152:Cyclic GMP; D000241:Adenosine; D007545:Isoproterenol; D002746:Chlorpromazine; D004298:Dopamine