Influence of agents that act on DNA and RNA synthesis on the activity of poly(ADP-Rib) polymerase.
The activity of poly(ADP-Rib) polymerase is enhanced in the presence of spermine and spermidine. Among the adenosine-like antibiotics tested, only formycin B and showdomycin cause an inhibition of the enzyme, which is competitive to NAD. The activity of poly(ADP-Rib) polymerase is not reduced by rifamycin, alpha-amanitin and 2-phenylethanol.
D000225:Adenine / Q000031:analogs & derivatives; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D003370:Coturnix; D004247:DNA / Q000096:biosynthesis; D004996:Ethidium / Q000494:pharmacology; D005260:Female; D005573:Formycins / Q000494:pharmacology; D007700:Kinetics; D009699:N-Glycosyl Hydrolases / Q000037:antagonists & inhibitors*; D009244:NAD+ Nucleosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010057:Oviducts / Q000201:enzymology*; D012313:RNA / Q000096:biosynthesis; D012787:Showdomycin / Q000494:pharmacology; D013095:Spermidine / Q000494:pharmacology*; D013096:Spermine / Q000494:pharmacology*; D013698:Templates, Genetic
D005573:Formycins; D013096:Spermine; D012313:RNA; D004247:DNA; D012787:Showdomycin; D009699:N-Glycosyl Hydrolases; D009244:NAD+ Nucleosidase; D004996:Ethidium; D000225:Adenine; D013095:Spermidine