Host restriction of Friend Leukemia virus coat protein synthesis.
Fv-1 gene-mediated host restriction of Friend leukemia virus replication was investigated in terms of coat protein synthesis. By using the assay of pseudotype formation with vesicular stomatitis virus. it was shown that under restricting growth conditions the availablity of leukemia virus coat protein for pseudotype formation was decreased. These studies appear to eliminate a pure assembly defect as the mechanism of Fv-1 host restriction.
D002460:Cell Line; D005622:Friend murine leukemia virus / Q000254:growth & development / Q000378:metabolism*; D005796:Genes; D006023:Glycoproteins / Q000096:biosynthesis*; D013045:Species Specificity; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication
D006023:Glycoproteins; D014764:Viral Proteins