[Sleep and monoamines: differential radioautography of central neurons after systematic injection of tritiated 5-hydroxytryptophane (5 HTP 3H) or of dihydroxyphenylalanine (DOPA 3H)].
In normal cats 90 min. after the intravenous injection of 5 mg/kg of 5 HTP and 3H 5 HTP or DOPA and 3H DOPA a few reactive nerve cell bodies were identified by radioautography. On the contrary, 48 hrs. after p-chlorophenylalanin or subtotal lesion of raphe nuclei, these tracers showed numerous reactive neurons inside or outside the central monoaminergic systems.
D006916:5-Hydroxytryptophan / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001933:Brain Stem / Q000378:metabolism; D002415:Cats; D004295:Dihydroxyphenylalanine / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011903:Raphe Nuclei / Q000293:injuries; D012890:Sleep / Q000502:physiology*; D014316:Tritium
D014316:Tritium; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D010134:Fenclonine
Sommeil et monoamines: radioautographie différentielle de neurones centraux après injection périphérique de 5-hydroxytryptophane (5 HTP 3H) ou de dihydroxyphénylalanine tritiée (DOPA 3H).