[Effect of sodium oxybutyrate on regional blood circulation and on neural regulation of vascular tonus].
The effect of sodium hydroxybutyrate on the blood flow in the aorta, carotid, mesenteric and femoral arteries were studied on cats and dogs. The circulation was assessed by the electromagnetic and resistographic methods, in the anesthetized and nonanesthetized animals. The tonic activity was recorded in the sympathetic nerves and the EEG. Sodium hydroxybutrate was shown to decrease the sympathetic activity, resulting in the increase of the regional circulation and induced the EEG synchronization. The latter effect was more pronounced in the arotid arteries. It can be assumed that sodium hydroxybutyrate affects the nervous control of the blood vessels.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001775:Blood Circulation / Q000187:drug effects*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply; D002415:Cats; D004285:Dogs; D004562:Electrocardiography; D004569:Electroencephalography; D005121:Extremities / Q000098:blood supply; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007422:Intestines / Q000098:blood supply; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects*
D006885:Hydroxybutyrates; D012978:Sodium Oxybate
Vliianie oksibutirata natriia na regionarnoe krovoobrashchenie i nervmuiu reguliatsiiu sosudistogo tonusa