title: The leucocyte adherence inhibtion test in cancer of the large bowel.
abstract: A recently introduced assay of cell mediated immunity and humoral inhibitory factors has been evaluated in colorectal cancer patients. Using a perchloric acid extract of adenocarcinoma of the large bowel as antigen, 16/27 patients with colorectal cancer had significant cellular reactivity when their separated peripheral leucocytes were tested in homologous AB serum. In autologous serum only 7/27 had significant reactivity; 6/20 patients with a variety of other malignancies showed sensitization  to the colorectal antigen preparation. It is concluded that the leucocyte adherence inhibiton test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology*; D000368:Aged; D000917:Antibody Formation; D000951:Antigens, Neoplasm; D002448:Cell Adhesion; D003110:Colonic Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010472:Perchlorates; D012004:Rectal Neoplasms / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D010472:Perchlorates