Temporal variations in androgens and stress hormones in control and schizophrenic subjects.
Radioimmunoassay methods were employed to study the steroid hormones dehydroepiandrosterone (DHEA), cortisol, testosterone, and androstenedione in schizophrenic and control subjects. Observations were made at four different times during the day. Cortisol, testosterone, and androstenedione demonstrated no significant differences between the two subjects groups. DHEA was significantly below normal in the morning for the schizophrenic group, but within the range of the controls for subsequent determinations during the day. Control subjects show a similar circadian secretion pattern for both DHEA and cortisol. Schizophrenics show almost the same circadian secretion patterns for cortisol as do the controls.
D000728:Androgens / Q000097:blood*; D000735:Androstenedione / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000097:blood*; D013315:Stress, Psychological / Q000097:blood*; D013739:Testosterone / Q000097:blood
D000728:Androgens; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D006854:Hydrocortisone