Pancreatic neoplasms in an animal model: morphological, biological, and comparative studies.
After a short latency (15 weeks), a 100% incidence of pancreatic neoplasms was induced in Syrian golden hamsters, following the administration of 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN). Data extracted from reports of human pancreatic neoplasms were compared with findings relative to the induced neoplasms. The latter resembled human pancreatic tumors, in both biological and morphological aspects.
D000230:Adenocarcinoma / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D001835:Body Weight; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D006224:Cricetinae; D003537:Cystadenoma / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D012737:Sex Factors
D009602:Nitrosamines