The tumor-forming type of multiple myeloma. II. Clinical profile and therapeutic effect.
In the six cases of tumor-forming type as described in the part I of this series, the estimated ages at disease onset ranged from 55 to 82 years old. Tumor-forming sites consisted of three cases each in skull and ribs, and one each in pelvis and palate. Bone x-rays revealed usually larger punched-out lesions adjacent to smaller punched-out lesions with tumor formation corresponding to the larger lesion. Plasma cells averaged 5.8% in myelogram, and monoclonal immunoglobulin consisted all of IgG. Clinical stages were in IA in four patients vs. IIA in two, and single or combined chemotherapy worked well on all the patients. A comparative study on decrease of monoclonal immunoglobulin value against chemotherapy between tumor-forming and non-tumor-forming types was made. The uniqueness of the tumor-forming type was emphasized to arouse attention to appropriate therapeutic measures for these patients.
D000368:Aged; D001797:Blood Protein Electrophoresis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D009194:Myeloma Proteins / Q000032:analysis; D009367:Neoplasm Staging
D007074:Immunoglobulin G; D009194:Myeloma Proteins