[Effect of ACTH on the excretion of acid glycosaminoglycans in urine and on the content of haptoglobin in blood serum of rats in acute aseptic inflammation].
In aseptic inflammation an increase in excretion of acid glucosoaminoglycans with urine of rats was an earlier evidence for destructive processes in the main substance of connective tissues than an increase in content of haptoglobin in blood serum. The increase in content of haptoglobin in blood serum was probably caused by beginning reparative processes in the centre of impairment. The centre of inflammation, caused by subcutaneous administration of turpentine simultaneously with repeated injections of high doses of ACTH, was maintained in the rats longer than in animals, which were not treated with ACTH. In the case the most distinct increase in excretion of glycosoaminoglycans with urine was observed; content of haptoglobin was also increased in blood serum.
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D006025:Glycosaminoglycans / Q000652:urine*; D006242:Haptoglobins / Q000032:analysis*; D007249:Inflammation / Q000378:metabolism*; D051381:Rats
D006025:Glycosaminoglycans; D006242:Haptoglobins; D000324:Adrenocorticotropic Hormone
Viliianie aktg na zkskretsiiu kislykh glikozaminoglikanov (kgag) s mochoĭ i na soderzhanie gaptoglobina v syvorotke krovi krys pri ostrom asepticheskom vospalenii