[Effect of urethane on the granulopexic activity of the reticuloendothelial system and the production of virus inhibiting factor or interferon].
Urethane (ethyl carbamate) did not affect the rate of the clearance of carbon from the blood in splenectomized mice, while this compound slowed down the carbon clearance in intact mice. Production of virus-inhibiting factor (IF) or interferon, especially early IF induced by virus was impaired by urethane in splenctomized mice as well as intact ones. The role of reticulo-endothelial system in IF formation was discussed.
D000818:Animals; D007372:Interferons / Q000096:biosynthesis / Q000097:blood; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects*; D013156:Splenectomy; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology*
D014520:Urethane; D007372:Interferons
Influence de l'uréthanne sur l'activité granulopexique du système réticulohistiocytaire et la formation du facteur inhibiteur des virus ou interféron.