[Hypophyseal gonadotropin secretion in sexual precocity with McCune-Albright's syndrome].
In three young girls with isosexual precocity and fibrous dysplasia of bones, plasma gonadotropins (LH and FSH) response to releasing hormone (LH-RH) has been much under the mean response in true female precocious puberty. These data and those previously reported in the literature suggest that MacCune-Albright's syndrome correlates to an hypothalamo-pituitary dysfunction rather than to a true prematurity.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000365:Age Determination by Skeleton; D002648:Child; D002675:Child, Preschool; D004700:Endocrine System Diseases / Q000150:complications / Q000188:drug therapy; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000150:complications* / Q000188:drug therapy; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D006065:Gonadotropins, Pituitary / Q000378:metabolism* / Q000652:urine; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008525:Medroxyprogesterone / Q000627:therapeutic use; D010859:Pigmentation Disorders / Q000150:complications / Q000188:drug therapy; D011629:Puberty, Precocious / Q000150:complications* / Q000188:drug therapy; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D006065:Gonadotropins, Pituitary; D004970:Estrone; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D013006:Growth Hormone; D008525:Medroxyprogesterone; D013974:Thyroxine
La secretion gonadotrope hypophysaire dans la precocite sexuelle du syndrome de Mc Cune-Albright