Properties of cells transformed by DNA tumor viruses.
Transformation by the papovaviruses, SV40 and polyoma, is reviewed briefly, including factors that affect the frequency of transformation. Virus markers useful in the determination of the etiology of virus-free tumors are described, including viral DNA, viral mRNA, virus-induced antigens, and the rescue of infectious virus. Finally, the evidence that viral genes are involved in the maintenance of transformation is presented.
D002471:Cell Transformation, Neoplastic; D004261:DNA Replication; D009154:Mutation; D010641:Phenotype; D011120:Polyomavirus; D013539:Simian virus 40; D014779:Virus Replication