title: Effect of tsl mutations in decreasing radiation sensitivity of a recA- strain of Escherichia coli K-12.
abstract: It has been shown previously that the radiation sensitivity of lexA- strains of Escherichia coli K-12 can be suppressed by thermosensitive mutations (designated tsl) that are closely linked to the lexA locus and are thought to be intragenic suppressors of lexA mutations (Mount et al., 1973). When a recA mutation is crossed into a suppressed tsl- strain, the extreme radiation sensitivity usually conferred by a recA mutation is decreased, but there is no detectable change in genetic recombination deficiency. Increased resistance to UV in the tsl-reA-strains depends upon ability to synthesize active uvrA+ product.
mesh_terms: D002455:Cell Division; D002470:Cell Survival; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism / Q000528:radiation effects*; D008698:Mesylates / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D011830:Radiation Effects; D011995:Recombination, Genetic; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D004269:DNA, Bacterial; D008698:Mesylates; D008937:Mitomycins