LH-RH-sensitive adenylate cyclase in isolated plasma membranes of rat adenohypophyses.
The adenylate cyclase system in isolated plasma membranes of rat adenohypophyses was studied. Formation of cAMP was found to be dependent on plasma membrane protein. Production of cAMP could be stimulated by the addition of LH-RH. This process was shown to be a function of LH-RH concentration. Basal and stimulated cAMP could be stimulated by NaF. The results of the present experiments suggest that cAMP formation is time dependent. The synthesis of cAMP is a possible effector of LH-RH actions.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D010902:Pituitary Gland / Q000201:enzymology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical
D007987:Gonadotropin-Releasing Hormone; D000242:Cyclic AMP; D000262:Adenylyl Cyclases