Circadian variation of the streptozotocin-diabetogenic effect in mice.
Streptozotocin was injected in normal mice every 4 h, during the day. Greatest number of diabetic animals were obtained at 16.00 h (95%) and lowest at 08.00 h (50%). Magnitude of hyperglycemia also showed similar distribution. This effect might be considered when planning its use for both experimental and clinical purposes.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002940:Circadian Rhythm; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006029:Glycosuria; D051379:Mice; D013311:Streptozocin
D001786:Blood Glucose; D013311:Streptozocin