[Gram negative bacillus septicemias. Results of treatment of 31 gram negative bacillus septicemias using intravenous nalidixic acid].
Enterobacteria multiresistant to usual antibiotics, often remain sensitive to nalidixic acid, sometimes as a result of synergy with polymixins. Use of the intravenous route makes it possible to obtain more than adequate serum levels. Pharmacological study has indicated appropriate doses in terms of renal function. Intravenous nalidixic acid has been used in the treatment of 31 cases of Gram negative septicaemia, with success in 22. These results are all the more significant given that the patients were all seriously ill, cultures having grown multiresistant organisms and that nalidixic acid was used only after other antibiotics had failed.
D001002:Anuria / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004361:Drug Tolerance; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000378:metabolism; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D010530:Peritoneal Dialysis; D011113:Polymyxins / Q000627:therapeutic use; D006435:Renal Dialysis; D018805:Sepsis / Q000188:drug therapy*
D011113:Polymyxins; D009268:Nalidixic Acid
Septicémies à bacilles Gram négatif. Résultats du traitement de 31 septicémies à bacilles Gram négatif per l'acide nalidixique intra-veineux