title: Peripheral neuropathy in acrodermatitis chronica atrophicans (Herxheimer).
abstract: Acrodermatitis chronica atrophicans is a dermatological condition that takes a chronically progressive course and finally leads to a widespread atrophy of the skin. Involvement of the peripheral nervous system is frequently observed, predominantly a sensory polyneuropathy. General reactions, the effect of penicillin treatment, the histological findings, and reports concerning a communicable agent transmittable from human to human as well in tissue cultures point to an infectious disease. Acrodermatitis chronica atrophicans follows a peculiar geographical distribution forming clusters of high prevalence in certain regions. Transmission by ticks is suggested.
mesh_terms: D000169:Acrodermatitis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D000368:Aged; D001284:Atrophy / Q000150:complications; D004576:Electromyography; D005860:Germany, West; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction; D010406:Penicillins / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000503:physiopathology; D011930:Reaction Time; D013577:Syndrome; D013997:Time Factors
chemical_list: D010406:Penicillins