title: Potential carcinogenicity of food additives and contaminants.
abstract: The potential role in carcinogenesis of food additives and contaminants presents a complex problem in terms of assessing the risk to the general public. Long-term testing in laboratory animals is still the most feasible method for determining potential carcinogenicity of various chemicals. The disadvantages encountered in the present methods of animal testing are discussed and a review is made of the current status of particular food additives and contaminants under scrutiny as possible carcinogens. It is suggested that, since it may not be possible to remove all carcinogenic materials from the environment, methods to mitigate or neutralize their harmful effects should be sought. Greater cooperation is called for among food technologists, toxicologists, laboratory researchers, and epidemiologists in the decision-making process regarding the role of possibly carcinogenic additives and contaminants.
mesh_terms: D015073:2-Acetylaminofluorene / Q000633:toxicity; D000452:Aldrin / Q000633:toxicity; D000476:Alkanesulfonates / Q000633:toxicity; D000640:Amitrole / Q000633:toxicity; D002219:Carbamates / Q000633:toxicity; D002273:Carcinogens; D003494:Cyclamates / Q000633:toxicity; D003634:DDT / Q000633:toxicity; D004026:Dieldrin / Q000633:toxicity; D004054:Diethylstilbestrol / Q000633:toxicity; D004785:Environmental Pollutants; D005503:Food Additives / Q000633:toxicity*; D005505:Food Coloring Agents / Q000633:toxicity; D010671:Phenylurea Compounds / Q000633:toxicity; D011092:Polyethylene Glycols / Q000633:toxicity; D011136:Polysorbates / Q000633:toxicity; D011724:Pyridazines / Q000633:toxicity; D012439:Saccharin / Q000633:toxicity; D013228:Stearates / Q000633:toxicity; D013549:Sweetening Agents / Q000633:toxicity; D013853:Thioacetamide / Q000633:toxicity; D013890:Thiourea / Q000633:toxicity; D014752:Vinyl Chloride / Q000633:toxicity
chemical_list: D000476:Alkanesulfonates; D002219:Carbamates; D002273:Carcinogens; D003494:Cyclamates; D004785:Environmental Pollutants; D005503:Food Additives; D005505:Food Coloring Agents; D010671:Phenylurea Compounds; D011136:Polysorbates; D011724:Pyridazines; D013228:Stearates; D013549:Sweetening Agents; D013853:Thioacetamide; D011092:Polyethylene Glycols; D004054:Diethylstilbestrol; D015073:2-Acetylaminofluorene; D003634:DDT; D012439:Saccharin; D013890:Thiourea; D004026:Dieldrin; D000452:Aldrin; D014752:Vinyl Chloride; D000640:Amitrole