Combined immunodeficiency and vaccine-related poliomyelitis in a child with cartilage-hair hypoplasia.
Patients previously described with cartilage-hair hypoplasia, a distinctive form of short-limbed dwarfism, have been found to have deficient cell-mediated immunity with intact antibody-mediated immunity. The patient with cartilage-hair hypoplasia described in the present report is unusual in that she had both deficient antibody-mediated immunity and deficient cell-mediated immunity. In addition, she developed severe, vaccine-related paralytic poliomyelitis. This complication suggests that live viral vaccines should not be administered to children with short-limbed dwarfism until the form of short-limbed dwarfism is established and immunologic evaluation is performed when indicated.
D001842:Bone and Bones / Q000000981:diagnostic imaging; D002357:Cartilage Diseases / Q000150:complications* / Q000276:immunology; D004392:Dwarfism / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D007223:Infant; D011051:Poliomyelitis / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology*; D017955:Poliovirus / Q000302:isolation & purification; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D011859:Radiography; D014611:Vaccination / Q000009:adverse effects
D007136:Immunoglobulins; D011054:Poliovirus Vaccine, Inactivated