[Effect of cyclic adenosine-3', 5'-monophosphate on cells of experimental lympholeukemia L-5178].
A study was made of the effect of cyclic adenosine-3',5'-monophosphate (cAMP) dibutyril-cAMP and theophylline (phosphoesterase inhibitor - an enzyme transforming adenosine-3'-5'-monophosphate into adenosine-5'-monophosphate) on the intensity of proliferation (by the increase in the content of nucleic acids in the culture), DNA synthesis (by the H3-thymidine incorporation) and on the transplantation properties (the capacity to repopulation in the animal organism) of leukemic cells of the L-5178 strain. It was found that cAMP in a concentration of 0.8 mM considerably inhibited the H3-thymidine incorporation, retarded the proliferation and decreased the transplantation capacity of leukemic cells. Theophylline and dibutyril-cAMP had a comparatively low inhibitory capacity on the DNA synthesis, proliferative activity and the transplantation properties of the cells.
D000818:Animals; D003994:Bucladesine / Q000627:therapeutic use; D000242:Cyclic AMP / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013806:Theophylline / Q000627:therapeutic use
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP
Vliianie tsiklicheskogo adenozin-3',5'-monofosfata na kletki éksperimental'nogo limfoleĭkoza L-5178