Cellular transformation in vitro induced by herpes simplex virus (HSV). Note III. Oncogenicity of some HSV-2-transformed cell lines.
At high in vitro passage levels HSV-2-transformed hamster and rat cell lines were oncogenic for the homologous animals, inducing fusocellular or round-cell sarcomas. The cell lines obtained by in vitro cultivation of the tumors were free of infectious virus.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D046508:Culture Techniques; D006561:Herpes Simplex / Q000150:complications; D009369:Neoplasms / Q000209:etiology; D009858:Oncogenic Viruses; D051381:Rats; D018139:Simplexvirus / Q000032:analysis*; D014776:Virus Cultivation