Bioassay of 2, 4, 5-trichlorophenoxyacetic acid for carcinogenicity in mice.
Adult mice of strains C3Hf and XVII/G received 2, 4, 5-T by continuous oral administration (80 ppm in the diet). The 2, 4, 5-T preparation contained less than 0-05 ppm of dioxins. In 2, 4, 5-T -treated C3Hf mice a significant increase in the incidence of neoplastic lesions was found. No significant difference was found in the XVII/G strain between the treated and control mice. Rare forms of tumours, which were not observed in the controls, were present in the 2, 4, 5-t -treated C3Hf mice.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D004147:Dioxins / Q000633:toxicity; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D012737:Sex Factors
D004147:Dioxins; D015085:2,4,5-Trichlorophenoxyacetic Acid