title: [Effect of serotonin on processes of elaboration and fixation of heterogeneous temporary connections].
abstract: The effect of serotonin (5-OT) level in the brain on the elaboration and retention of heterogenous conditioned reflexes was studied in the experiments on rats and mice. Redundancy of 5-OT deteriorated the retention of defensive and alimentary conditioned reflexes and almost fully prevented the fixation of drinking conditioned reflexes. The reduction of 5-OT led to less pronounced disorders in the retention of conditioned reflexes. With a prolonged delay of electrocutaneous reinforcement (from 5 to 10 s) the control animals showed slower elaboration of two-side avoidance reflexes, while their retention was uneffected. The redundancy of 5-OT in these conditions accelerated the elaboration but at the same time deteriorated the retention as in case of 5-second delay. A conclusion is made that with the changed level of 5-OT the impairment of conditioned reflexes retention doesn't depend on the changes in the speed of their elaboration. The "point of application" of changes in 5-OT content lies in the process of the temporary connection consolidation. The degree of 5-OT participation in these processes depends on the characteristics of elaborated conditioned reflexes.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D010134:Fenclonine / Q000494:pharmacology; D005502:Food; D007490:Iproniazid / Q000494:pharmacology; D008568:Memory / Q000502:physiology*; D051379:Mice; D051381:Rats; D012153:Retention, Psychology / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D013045:Species Specificity; D014867:Water
chemical_list: D014867:Water; D012701:Serotonin; D007490:Iproniazid; D010134:Fenclonine
vernacular_title: Vliianie serotonina na protsessy vyrabotki i fiksatsii raznorodnykh vremennykh sviazeĭ.