title: Studies of human papovavirus tumor antigen in experimental and human cerebral neoplasms.
abstract: Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D001932:Brain Neoplasms / Q000276:immunology*; D002277:Carcinoma / Q000276:immunology; D002551:Cerebral Ventricle Neoplasms / Q000276:immunology; D002831:Choroid Plexus; D006224:Cricetinae; D005354:Fibrosarcoma / Q000276:immunology; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology*; D027382:Polyomaviridae; D012535:Scalp; D013539:Simian virus 40
chemical_list: D000951:Antigens, Neoplasm; D000956:Antigens, Viral