[Hormonal regulation of 5 alpha-reductase activity in anterior pituitary gland microsomes of the male rat].
It was previously shown that the microsomal 5 alpha-reductase activity in the male rat pituitary was increased by castration. Subcutaneous administration of androgens to castrated rats prevented the rise in 5 alpha-reductase activity. Their relative efficiency was as follows: 5 alpha-dihydrotestosterone greater than 5 alpha-androstane-3 alpha, 17 beta-diol greater than testosterone. Under our experimental conditions 5 alpha-androstane-3 beta, 17 beta-diol and estrogens were inefficient. The rise in 5 alpha-reductase activity following castration is exclusively located in hypophysis and it is probably due to an increased of the enzyme biosynthesis.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000728:Androgens / Q000494:pharmacology; D015113:Androstane-3,17-diol / Q000378:metabolism; D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D004960:Estradiol Dehydrogenases / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000201:enzymology*; D051381:Rats
D000728:Androgens; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D004958:Estradiol; D010088:Oxidoreductases; D004960:Estradiol Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Régulation hormonale de l'activité de la 5 alpha-réductase des microsomes de l'hypophyse antérieure du rat mâle.