Stimulation of protein synthesis in vivo in immature mouse testis by FSH.
Human pituitary FSH was found to increase the incorporation of tritiated lysine into testicular protein in prepubertal mice in vivo. Radioactivity was measured in washed trichloracetic acid precipitates prepared from crude testicular homogenates. The time of maximum response was 8 to 16 hr after subcutaneous injection of the hormone. This was considerably later than the maximum response in vitro reported by other workers. Neither HCG nor dibutyryl cyclic 3',5'-adenosine monophosphate had a significant effect on the incorporation of lysine.
D000367:Age Factors; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008099:Liver / Q000378:metabolism; D008239:Lysine / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D014176:Protein Biosynthesis; D013268:Stimulation, Chemical; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D003994:Bucladesine; D005640:Follicle Stimulating Hormone; D013806:Theophylline; D008239:Lysine