The mechanism of inhibition on the endogenous respiration of Ehrlich ascites tumor cells by the cyanine dye diS-C3-(5).
The cyanine dye 3,3'-dipropyl-2,2'-thiadicarbocyanine iodide [diS-C3(5)] was found to be a potent inhibitor of endogenous respiration of Ehrlich ascites tumor cells. This effect is believed to involve both rotenone and uncoupler type actions of the dye on the electron transport system of the mitochondria.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D052160:Benzothiazoles; D002232:Carbocyanines / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004140:Dinitrophenols / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D005459:Fluorides / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D012402:Rotenone / Q000494:pharmacology
D052160:Benzothiazoles; D002232:Carbocyanines; D004140:Dinitrophenols; D009840:Oligomycins; D011804:Quinolines; D012402:Rotenone; C012944:3,3'-dipropyl-2,2'-thiadicarbocyanine; D000251:Adenosine Triphosphatases; D005459:Fluorides