Effects of emulsified iodo-lipids. A toxicologic investigation in the rabbit.
Two different iodized oil emulsion have been intravascularly injected into rabbits, one with a particle size of 15 mum or more and one with a size of about 1 mum. The effects of the emulsions have been evaluated on the brain, the heart, the kidney, the liver and the circulation. The reactions to the small particle emulsion was minor, especially if administered slowly. The injection site was of critical importance. The safest place for injection was the superior mesenteric artery. If supplied directly to the brain or the heart the emulsions were often deleterious, particularly the coarse one.
D000818:Animals; D001921:Brain / Q000187:drug effects; D017023:Coronary Angiography; D004655:Emulsions; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008638:Mesenteric Arteries / Q000000981:diagnostic imaging; D011817:Rabbits; D012077:Renal Artery / Q000000981:diagnostic imaging
D004655:Emulsions; D007459:Iodized Oil