[Induction of endogenous C-type virus by 5-iododeoxyuridine and augmentation of this induction by polycyclic hydrocarbons].
When the MLg Mouse cells were treated with the chemical carcinogens, in the presence of microsomal enzymes and NADPH2 after 5-iododeoxyuridine (IUdR) treatment, the induction frequency of the endogenous C-type virus was increased by nearly 10-fold in comparison with the cultures treated with IUdR only. In the preliminary screening of several polycyclic hydrocarbons including carcinogenic and non-carcinogenic products, apparently there was no correlation between the carcinogenecity in vivo and the stimulation capacity of IUdR induced C-type virus activation in our test conditions.
D002478:Cells, Cultured; D004357:Drug Synergism; D007065:Idoxuridine / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D011083:Polycyclic Compounds / Q000378:metabolism / Q000494:pharmacology*; D012190:Retroviridae / Q000254:growth & development*; D013268:Stimulation, Chemical; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
D011083:Polycyclic Compounds; D007065:Idoxuridine
Induction du virus endogène, type C, par la 5-iododéoxyuridine; augmentation de cette induction par des hydrocarbures polycycliques