Effect of protease inhibitors on focus formation by murine sarcoma virus.
The effect of six protease inhibitors, isolated from various species of actinomycetes, on focus formation by murine sarcoma virus was examined. Pepstatin was the only inhibitor. The treatment of cells with pepstatin at various times possibly retards the early stage of infection with murine sarcoma virus.
D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D003260:Contact Inhibition / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology; D017988:Gammaretrovirus / Q000187:drug effects*; D007976:Leupeptins / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009842:Oligopeptides / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010196:Pancreatic Elastase / Q000494:pharmacology; D010436:Pepstatins / Q000494:pharmacology; D011480:Protease Inhibitors; D009053:Sarcoma Viruses, Murine / Q000187:drug effects*; D013820:Thermolysin / Q000037:antagonists & inhibitors
D002219:Carbamates; D004151:Dipeptides; D007976:Leupeptins; D009842:Oligopeptides; D009943:Organophosphorus Compounds; D010436:Pepstatins; D011480:Protease Inhibitors; D010196:Pancreatic Elastase; D013820:Thermolysin