Cyclosporin A: an immunosuppressive agent preferentially active against proliferating T cells.
The in vitro action of the immunosuppressive agent Cyclospirin A has been investigated using porcine cells. Lymphocyte proliferation induced in response to transplantation antigens and phytohaemagglutinin (PHA), was inhibited by this agent at doses that failed to inhibit mitogenisis in response to sheep anti-pig IgM, growth of kidney cell monolayers, and leukocyte migration.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002464:Cell Migration Inhibition; D005656:Fungal Proteins / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008934:Mitogens; D010456:Peptides, Cyclic / Q000494:pharmacology*; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology*
D005656:Fungal Proteins; D007166:Immunosuppressive Agents; D008934:Mitogens; D010456:Peptides, Cyclic