title: Beneficial effects of pulsatile perfusion in the hypertrophied ventricle during ventricular fibrillation.
abstract: To assess the potential benefit of pulsatile perfusion inthe hypertrophied heart during fibrillation, 10 dogs with left ventricular hypertrophy, produced by previous supravalvular aortic banding, were used to compare linear and pulsatile perfusion in the fibrillating heart during total cardiopulmonary bypass. The mass spectrometer was used to measure subendocardial PCO2 and PO2 (PmCO2 and PmO2), and radioactive microspheres were utilized to measure myocardial blood flow in the same layers. Pulsatile perfusion was established using the recently develop "bubble tubing," which produces a pulse pressure of at least 20 mm Hg and can be used in a standard roller-pump apparatus. Both linear and pulsatile flows were compared at mean aortic root pressures of 80 and 50 mm Hg, and these four combinations of aortic root pressure and type of flow were employed for periods of 30 minutes each. Myocardial ischemia developed during linear coronary perfusion at 50 mm Hg, as evidenced by an elevation of PmCO2. Ischemia was not evident during pulsatile perfusion at the same mean pressure. Reversal ischemia was a result of increased myocardial blood flow and pulsatile perfusion, and this increase was shown to occur maximally in the deeper subendocardial layer. Ischemia was not eviden during linear or pulsatile perfusion at an mean perfusion pressure 80 mm Hg. Thus, if lower perfusion pressures are to be tolerated in patients with left ventricular hypertrophy, pulsatile perfusion with the bubble tubing technique may prevent the development of subendocardial ischemia or infarction.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D006332:Cardiomegaly / Q000150:complications* / Q000503:physiopathology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D004285:Dogs; D005069:Evaluation Studies as Topic; D013058:Mass Spectrometry; D008863:Microspheres; D010100:Oxygen / Q000097:blood; D014693:Ventricular Fibrillation / Q000150:complications* / Q000503:physiopathology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen