Fetal calf serum alters cyclic adenosine 3',5'-monophosphate's effect on heme synthesis in vitro.
An investigation of the effect of cAMP on heme synthesis of rat bone marrow cells revealed that at 10(-2) M this cyclic nucleotide inhibits heme synthesis and that optimum stimulation occurs at 10(-4) M. Some unidentified constituent of fetal calf serum in the culture medium modifies the direction and degree of cAMP's effect.
D000818:Animals; D001769:Blood; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006418:Heme / Q000096:biosynthesis*; D008297:Male; D051381:Rats
D006418:Heme; D000242:Cyclic AMP