Modification of myometrial activity in vivo by administration of cyclic nucleotides and theophylline to the pregnant rat.
Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short-term infusions of theophylline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were investigated. All three compounds caused a decrease in oxytocin-induced, prostaglandin F2alpha-induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre-infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology*; D005260:Female; D010121:Oxytocin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
D011460:Prostaglandins F; D010121:Oxytocin; D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP