Delay in growth and the development of nephritis in rats treated with interferon preparations in the neonatal period.
Suckling rats were injected for 14 to 17 days with potent rat-cell-culture interferon preparations or various heterologous interferon or control preparations. Only treatment with rat interferon resulted in a delay in growth and maturation of different organs and the subsequent development of an "immune complex" type nephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis, whereas only 3 of 99 rats in the various control groups had minimal renal lesions. Deposits of IgG and C3 along the glomerular basement membrane were only seen in interferon-treated rats.
D000818:Animals; D003176:Complement C3 / Q000032:analysis; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D006128:Growth / Q000187:drug effects*; D007105:Immune Complex Diseases / Q000139:chemically induced; D007074:Immunoglobulin G / Q000032:analysis; D007372:Interferons; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects
D003176:Complement C3; D007074:Immunoglobulin G; D007372:Interferons