title: Apparent accelerated aging of human collagen in diabetes mellitus.
abstract: The chronologic ages of human subjects were determined experimentally by enzymatic digestion of tendon collagen samples. Determined age closely matched actual age for individuals dying with a variety of major diseases. Juvenile diabetics did not fit this pattern; their experimentally determined ages were significantly greater than their actual ages. This raises the possibility of relationships between diabetes mellitus, changes in connective tissue, and accelerated aging.
mesh_terms: D000328:Adult; D000375:Aging; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003964:Diaphragm / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D003012:Microbial Collagenase / Q000494:pharmacology; D008875:Middle Aged
chemical_list: D003094:Collagen; D003012:Microbial Collagenase