title: Safety factor in single human motor end-plates studied in vivo with single fibre electromyography.
abstract: In a single fibre EMG investigation on healthy subjects the relationship between the neuromuscular jitter and the safety factor of the motor end-plate relative to curare was studied. A positive correlation was found between the jitter increase after a standard dose of D-tubocurarine and the initial jitter. The conclusion was drawn that the neuromuscular jitter can be used as an indicator of the safety factor. There are a number of nerve-muscle disorders in which the jitter is increased, probably indicating a reduced safety factor which may be of clinical importance when these patients are subjected to diseases or drugs which would otherwise not produce neuromuscular symptomatology.
mesh_terms: D000328:Adult; D003202:Computers, Analog; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005071:Evoked Potentials; D006801:Humans; D008875:Middle Aged; D008959:Models, Neurological; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014403:Tubocurarine