25-Hydroxycholecalciferol inthe management of rickets associated with extrahepatic biliary atresia.
In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.
D000284:Administration, Oral; D001652:Bile Ducts / Q000002:abnormalities*; D002675:Child, Preschool; D002762:Cholecalciferol / Q000378:metabolism; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D006900:Hydroxylation; D007223:Infant; D007408:Intestinal Absorption; D008099:Liver; D012279:Rickets / Q000188:drug therapy* / Q000209:etiology
D006887:Hydroxycholecalciferols; D002762:Cholecalciferol