Effects of imipramine, nomifensine and d-amphetamine on type B monoamine oxidase, cyclic AMP phosphodiesterase and dopamine-beta-hydroxylase.
The three dissimilar structural antidepressant drugs, imipramine, nomifensine and d-amphetamine, were compared for their effects on type B monoamine oxidase, cyclic AMP phosphodiesterase and dopamine-beta-hydroxylase. Three antidepressant drugs caused a dose-dependent inhibition on type B monoamine oxidase. Of the three drugs, imipramine had a most potent effect. Unlike d-amphetamine, both imipramine and nomifensine inhibited the cyclic AMP phosphodiesterase activity at concentrations more than 10(-4)M. No effect was observed below this concentration. All drugs seemed to have little or no effects on the partially purified dopamine-beta-hydroxylase activity. The weak inhibitory effects of nomifensine on these three enzymes may not be attributable to its antidepressant properties. Morphine had no effect on the three enzyme activities.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D007099:Imipramine / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines / Q000037:antagonists & inhibitors; D010726:Phosphodiesterase Inhibitors; D051381:Rats
D000928:Antidepressive Agents; D007546:Isoquinolines; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D010726:Phosphodiesterase Inhibitors; D004299:Dopamine beta-Hydroxylase; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007099:Imipramine; D003913:Dextroamphetamine