The appearance of factors influencing migration of lymphocytes (LyMIF and LyMSF) in rabbit mixed lymphocyte cultures.
In vitro migration of mixtures of peripheral blood lymphocytes derived from 26 pairs of rabbits was significantly suppressed in 73% of cultures, significantly enhanced in 4% and unchanged in 23%, as compared to the corresponding monocultures. Sensitization of 26 rabbits by kidney graft resulted in more frequent appearance of migration enhancing factor. Six days after grafting 54% of donor-recipient mixed cultures showed enhancement of migration, 31% inhibition and 15% no effect. No enhancing factors were produced on the 9th day.
D000818:Animals; D002464:Cell Migration Inhibition; D007376:Interleukin-2 / Q000096:biosynthesis; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000502:physiology*; D008222:Lymphokines / Q000096:biosynthesis*; D011817:Rabbits
D007376:Interleukin-2; D008222:Lymphokines