Neoplasms of immunoregulatory cells.
This paper provides an overview of neoplasms which appear to be derived from immunoregulatory cells. Normal T cells play a critical role in the regulation of humoral immune responses by acting as potentiators (helper cells) or inhibitors (suppressor cells) of the B cell transition into immunoglobulin-secreting plasma cells. Certain patients with leukemias or lymphomas of T-cell origin may provide a resource for obtaining homogeneous populations of cells which act as either helper cells (e.g., some patients with the Sézary syndrome) or suppressor cells (e.g., some patients with acute or subacute T-leukemia). The clinical and theoretic implications of such immunoregulatory cell neoplasms are discussed.
D000361:Agammaglobulinemia / Q000150:complications; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007564:Japan; D007938:Leukemia / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000150:complications / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D012397:Rosette Formation; D012751:Sezary Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins