[Influence of fenoterol of cAMP levels and motility on the rat uterus in vitro (author's transl)].
CAMP levels of isolated rat uteri (2nmol/g wwt) were increased by Fenoterol (10(-4)--1 mug/ml) in a dose dependent manner reaching concentrations of more than 10nmol/g withing 2--5 min. AT 2 TIMES 10(-3) MUG/ML Fenoterol inhibited spontaneous contractions of the rat uterus in vitro. A 10,000 fold higher dosis of Fenoterol was needed to elicit a similar degree of inhibition, when contractions were induced by 0.6 mU/ml Oxytocin. However cAMP levels were elevated by Fenoterol in presence of Oxytocin, uterine contractions were not inhibited, i.e. the elevation of cAMP after administration of Fenoterol is correlated with a relaxant effect only in uteri contracting spontaneously.
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D010121:Oxytocin / Q000037:antagonists & inhibitors; D010477:Perfusion; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000032:analysis / Q000187:drug effects*
D004983:Ethanolamines; D005280:Fenoterol; D010121:Oxytocin; D000242:Cyclic AMP
Wirkung von Fenoterol (Patusisten) auf die Mtilität und den Gehalt des cyclischen Adenosin 3',5'-Monophosphat des isolierten Rattenuterus