[Effect of glycolysis inhibitors on the uptake of metronidazole by the protozoa Tritrichomonas foetus and Entamoeba invadens].
Uptake of metronidazole by the anaerobic protozoa, Tritichomonas foetus and Entamoeba invadens is dependent on the energy metabolism of these organisms. The inhibitors of glycolysis, iodoacetamide and sodium fluoride, inhibit the uptake. An atmosphere of hydrogen eliminates this inhibition in the hydrogenase-containing T. foetus but not in E. invadens which lacks the enzyme.
D004734:Energy Metabolism; D004747:Entamoeba / Q000187:drug effects / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D007460:Iodoacetamide / Q000494:pharmacology; D008795:Metronidazole / Q000378:metabolism*; D012969:Sodium Fluoride / Q000494:pharmacology; D014318:Tritrichomonas / Q000187:drug effects / Q000378:metabolism*
D008795:Metronidazole; D012969:Sodium Fluoride; D007460:Iodoacetamide
L'action des inhibiteurs de la glycolyse sur l'absorption du métronidazole par les protozoaires Tritrichomonas foetus et Entamoeba invadens.