Pathogenesis of pyelonephritis. Escherichia coli-induced renal ultrastructural changes.
Escherichia coli-induced renal ultrastructural changes were observed 4 hr after the intravenous injection of 2 times 10-minus 6 bacteria. The initial changes consisted of mitochondrial swelling followed by intracellular vacuolation, nuclear membrane dilation, and increased lysosomal phagocytic activity. Alterations in the appearance of proximal tubular lysosomes included a loss of osmiophilic staining properties. Many of the involved cells showed necrosis and can presumably act as a nidus for bacterial proliferation.
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D004926:Escherichia coli / Q000472:pathogenicity*; D005260:Female; D002479:Inclusion Bodies / Q000473:pathology; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D007683:Kidney Tubular Necrosis, Acute / Q000473:pathology; D007686:Kidney Tubules, Distal / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000473:pathology; D008247:Lysosomes / Q000473:pathology; D008933:Mitochondrial Swelling; D011704:Pyelonephritis / Q000382:microbiology* / Q000473:pathology; D051381:Rats