Experimental study of dibutyryl cyclic AMP; its metabolic effects observed in anesthetized human subjects.
Metabolic effects of N6,O2-dibutyryl adenosine 3',5'-monophosphate (DBcAMP) were studied in 10 anesthetized patients who were divided at random into two groups each consisting of 5 patients. DBcAMP dissolved in 200 ml of physiological saline was administered intravenously at a rate of 10 mg/min for 20 min in one group and 20 mg/min for 20 min in the other group. DBcAMP infusion at either rate increased levels of blood glucose, immunoreactive plasma insulin, blood pyruvate and blood redox-potential while it reduced levels of glycerol, non-esterified fatty acid and inorganic phosphate. These findings suggest that 200 and 400 mg of DBcAMP stimulates glycogenolysis and glycolysis but inhibits lipolysis in man.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000758:Anesthesia; D001786:Blood Glucose / Q000378:metabolism; D003994:Bucladesine / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood; D011773:Pyruvates / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D002245:Carbon Dioxide; D010758:Phosphorus; D003994:Bucladesine; D005990:Glycerol; D002118:Calcium