title: Probiotics. Antistaphylococcal and antifibrinolytic activities of omega-amino-and omega-guanidinoalkanisulfonic acids.
abstract: A series of omega-aminoalkanesulfonic acids (1-5) and omega-guanidinoalkanesulfonic acids (6-9) has been tested for antistaphylococcal and antifibrinolytic activities. Most of the omega-aminoalkanesulfonic acids and 6 produced better protection against Staphylococcus aureus infections in mice than gamma-aminobutyryl-L-histidine. Compound 4 was the best antistaphylococcal agent among the omega-aminoalkanesulfonic acids and compound 6 among the omega-guanidinoalkanesulfonic acids. Most of the omega-aminoalkanesulfonic acids have antifibrinolytic activity, while none of the omega-guanidinoalkanesulfonic acids has significant antifibrinolytic activity. Compound 4 possessed the highest antifibrinolytic activity which was equal to or greater than that of epsilon-aminohexanoic acid.
mesh_terms: D000476:Alkanesulfonates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001780:Blood Coagulation Tests; D002855:Chromatography, Thin Layer; D005342:Fibrinolysis / Q000187:drug effects; D006146:Guanidines / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000476:Alkanesulfonates; D000588:Amines; D000890:Anti-Infective Agents; D000933:Antifibrinolytic Agents; D006146:Guanidines