Effects of cadmium of the hydro-osmotic and natriferic responses to the toad bladder to vasopressin.
Cadmium, 10(-3) mol/l on the mucosal or 10(-5) mol/l on the serosal side of the toad urinary bladder, inhibits the hydro-osmotic effect of vasopressin. This inhibition is irreversible. The osmotic transfer of water in the absence of vasopressin was unaffected by the presence of the Cd2+. The hydro-osmotic response to cyclic AMP was also reduced by the Cd2+, but the response due to hypertonicity of the serosal bathing solution was unaffected. The short-circuit current (reflecting active transmural Na+ transport) was inhibited by 10(-3) mol Cd2+/l on the serosa, but was increased by 10(-3) mol/l at the mucosa or 10(-4) mol/l at the serosa. The natriferic response of the bladder to vasopressin was unaffected when Cd2+ was present under conditions that inhibited the hydro-osmotic response, further emphasizing that separate effector mechamisms may be involved for each effect.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D002024:Bufo marinus; D002104:Cadmium / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D007276:Injections, Intraventricular; D009995:Osmosis / Q000187:drug effects; D012704:Serous Membrane / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000378:metabolism; D014667:Vasopressins / Q000037:antagonists & inhibitors*; D014867:Water / Q000378:metabolism*
D002104:Cadmium; D014867:Water; D014667:Vasopressins; D001127:Arginine Vasopressin; D012964:Sodium; D000242:Cyclic AMP