Ethanol-induced depletion of cerebellar guanosine 3',5' -cyclic monophosphate.
Single doses of ethanol a severe depletion (95 percent) of cerebellar guanosine 3',5' -cyclic monophosphate (cyclic GMP) within 1 hour after administration. The degree of this depletion is dose-dependent and is a function of the amount of ethanol in the blood. Interactions between ethanol and cyclic GMP may account for some of the intoxicating properties of ethanol.
D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors
D000431:Ethanol; D006152:Cyclic GMP