title: Circadian periodicity a neurospora: alteration by inhibitors of cyclic AMP phosphodiesterase.
abstract: Three methyl xanthine inhibitors of adenosine 3',5'-monophosphate phosphodiesterase-theophylline, aminophyline, and caffeine-lengthen the period of the circadian conidiation rhythm of Neurospora. The effect are seen in wild-type strains and in three mutant strains with genetically altered period lengths. These results suggest the possible involvement of adenosine 3', 5'-monophosphate in the control of circadian rhythmicity.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D002110:Caffeine / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects*; D000242:Cyclic AMP / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D009154:Mutation; D009492:Neurospora crassa; D010726:Phosphodiesterase Inhibitors; D013806:Theophylline / Q000494:pharmacology
chemical_list: D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; D013806:Theophylline; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases