EM49, a new peptide antibiotic IV. The structure of EM49.
EM49 is a family of similar peptide antibiotics, each an octapeptide acylated with a beta-hydroxy fatty acid. This paper described the determination of the structure of the fatty acyl residue, the selective removal of this residue from the peptide portion of the molecule, and the sequential analysis of the peptide by the EDMAN method. The structure of EM49, 1, is derived by this degradation.
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D004139:Dinitrofluorobenzene; D005227:Fatty Acids / Q000032:analysis; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009842:Oligopeptides / Q000032:analysis*; D009904:Optical Rotation; D010443:Peptide Chain Termination, Translational; D011113:Polymyxins; D013844:Thiazoles; D013867:Thiohydantoins
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D009842:Oligopeptides; D011113:Polymyxins; D013844:Thiazoles; D013867:Thiohydantoins; D004139:Dinitrofluorobenzene