Sorting of signals from thermosensitive areas.
Of the several models proposed for the neural regulation of temperature in cold-exposed animals, two have been previously restated in dynamic form using CSMP. Subsequently, computer simulations have led to the design and execution of experiments for selection of the more appropriate model for cold-exposed rats. These experiments, as described in the present paper, have been interpreted as being consistent with the model which sorts signals from thermosensitive areas and channels the selected signals over separate neural pathways to independently control each mode of heat production. Since this model requires multiplication of neural signals, possible neuronal mechanisms which may underline such multiplication are discussed. In addition, parameter variation to account for febril responses and rate sensitivity have been evaluated.
D000818:Animals; D001833:Body Temperature Regulation; D001921:Brain / Q000502:physiology*; D003080:Cold Temperature; D003201:Computers; D004525:Efferent Pathways / Q000502:physiology; D004781:Environmental Exposure; D005334:Fever; D007031:Hypothalamus / Q000502:physiology; D008959:Models, Neurological; D051381:Rats; D012867:Skin / Q000294:innervation; D012881:Skin Temperature; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission; D013823:Thermoreceptors / Q000502:physiology*