Effect of the carboxyl-terminal tripeptide of vasopressin on plasma free fatty acids and cyclic adenosine monophosphate in man.
The carboxyl-terminal tripeptide of casopressin (Pro-Arg-Gly.NH2) and adrenocorticotrophic hormone (ACTH) were injected intravenously into six human subjects, and the effects of these peptides on plasma free fatty acids (FFA) and cAMP concentrations were compared with that of saline. Twenty mug of the tripetide and 100 mug of ACTH INCREASED THE PLASMA FFA CONCENTRATION TO THE SAME EXTENT, WHEREAS 200 MUG OF THE TRIPETIDE WAS WITHOUT THIS LIPOLYTIC EFFECT. ACTH and the smaller dose of the tripeptide elevated the plasma cAMP level only in the same two subjects.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D003864:Depression, Chemical; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D008297:Male; D010455:Peptides / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013997:Time Factors; D014667:Vasopressins / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D010455:Peptides; D014667:Vasopressins; D012965:Sodium Chloride; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP