[Cerebral granular cell tumor in the rat after intraperitoneal application of aflatoxin b1 during pregnancy (author's transl)].
On a rat, which has spontaneous died 12 months after 4 times i.p. application of aflatoxin during pregnancy, there has been found a frontal tumor barely of the size of a pepper-corn which came out from the leptomeninx. A comparison to the Abrikossoff tumor concerning the light- and electron-microscope as well as the nucleic-acid concentration is justified. The protein content of the granula of the tumor cells is higher than the values known in the granular-cell myoblastoma of man.
D000348:Aflatoxins / Q000009:adverse effects*; D000818:Animals; D002493:Central Nervous System Diseases / Q000139:chemically induced; D003937:Diagnosis, Differential; D005260:Female; D007274:Injections, Intraperitoneal; D008578:Meninges / Q000473:pathology; D008854:Microscopy, Electron; D009363:Neoplasm Proteins / Q000032:analysis; D009379:Neoplasms, Muscle Tissue / Q000032:analysis / Q000139:chemically induced* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D012509:Sarcoma / Q000473:pathology; D013997:Time Factors
D000348:Aflatoxins; D009363:Neoplasm Proteins
Granularzelltumor des ZNS bei der Rate nach intraperitonealer Applikation von Aflatoxin B1 während der Tragezeit