Enzyme activities in the epidermis of zinc-deficient rats.
Fifteen enzymes participating in epidermal energy metabolism in zinc-deficient and -supplemented rats were assayed utilizing fluorometric microchemical techniques. In the zinc-deficient group, the activities of six enzymes catalyzing glycolysis decreased by 30 to 50% of the control; the most dramatic decreases were found in phosphofructokinase and glyceraldehyde-3-phosphate dehydrogenase. Zinc deficiency caused a 31% decrease in the activity of glucose-6-phosphate dehydrogenase, a 63% decrease in fumarate hydratase, a 46% decrease in glutamate dehydrogenase, and a 30 to 40% decrease in aminotransferases.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D003677:Deficiency Diseases / Q000188:drug therapy; D005649:Fumarate Hydratase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D008297:Male; D010770:Phosphotransferases / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000201:enzymology*; D000637:Transaminases / Q000378:metabolism; D015032:Zinc / Q000172:deficiency* / Q000627:therapeutic use
D000429:Alcohol Oxidoreductases; D005954:Glucosephosphate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005969:Glutamate Dehydrogenase; D000637:Transaminases; D010770:Phosphotransferases; D005649:Fumarate Hydratase; D015032:Zinc