Factors influencing the lipolytic response of swine (Sus domesticus) adipose tissue: ontogeny.
Swine adipose tissue was not responsive to glucagon at any age and only marginally to adrenocorticotropin (ACTH). The latter response could be greatly magnified and the sensitivity increased by addition of theophylline (Theo). The maximal lipolytic activity (MAX) obtained with ACTH plus Theo was minimal in the newborn, greatly increased in young animals, and reduced during the growing period; however, the sensitivity did not change. The MAX for Theo (plus low epinephrine) yielded a pattern similar to ACTH, but the sensitivity changed (most sensitive in younger animals). The MAX and sensitivity obtained with dibutyryl cyclic adenosine monophosphate were not appreciably changed during development.
D000273:Adipose Tissue / Q000254:growth & development / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D050356:Lipid Metabolism; D008053:Lipid Mobilization; D013552:Swine / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology
D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D013806:Theophylline; D000242:Cyclic AMP