title: Ultrastructure of the fibrous subaortic "ring" in dogs with discrete subaortic stenosis.
abstract: The subaortic fibrous "ring" in Newfoundland dogs with discrete subaortic stenosis is characterized by the presence of large, uni- and multinucleated, rounded connective tissue cells that resemble chondrocytes in several respects. Connective tissue adjacent to these cells is rich in acid mucopolysaccharides, small but cross-banded collagen fibrils, and small, poorly developed elastic fibers. The chondrocyte-like cells contain numerous cisternae of rough surfaced endoplasmic reticulum and prominent Golgi complexes, and they are surrounded by thick, concentrically arranged layers of basement membrane-like material. The differentiation of cellular and extracellular components of connective tissue in subaortic fibrous rings clearly differs in humans and in dogs with discrete subaortic stenosis.
mesh_terms: D000818:Animals; D001020:Aortic Stenosis, Subvalvular / Q000473:pathology*; D001485:Basement Membrane / Q000648:ultrastructure; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology*; D002356:Cartilage / Q000648:ultrastructure; D003238:Connective Tissue / Q000648:ultrastructure*; D003593:Cytoplasm / Q000648:ultrastructure; D004285:Dogs; D005347:Fibroblasts / Q000648:ultrastructure; D006025:Glycosaminoglycans / Q000032:analysis; D006651:Histocytochemistry; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*
chemical_list: D006025:Glycosaminoglycans