title: [Botulism. Therapeutic management. Apropos of 36 cases].
abstract: Botulism is relatively common in the Vienne department as we have observed 36 cases over a peroid of 7 years. Other French cases, published over the last 10 years, included 10 to 19 cases in the largest series. In a total of 10 series, there were 105 cases. Botulism is caused, in most cases, by eating ham prepared on the farm. It gives rise to the usual clinical picture including paralysis of accommodation, dysphagia, digestive symptoms with abdominal pain and constipation and finally, bladder paralysis. The mild forms are fairly common. We did not observe any severe cases. Our patients were treated in two homogeneous series of 17 cases each ; two patients were given no treatment. Patients treated by sero-anatoxin therapy according to classical methods, evolved towards a cure within 21 days on average. Patients treated by sulfguanidin were cured within 24 days. This study permitted us to confirm that sero-anatoxin therapy is not essential. The disadvantages are the number of injections, the possibility of sometimes fatal hyper-sensitive reactions which, in the opinion of many authors, justifies routine cover with cortisone. This attitude does not seem to us justified owing to the usually benign nature of the botulism. The treatment with sulfaguanidin is well tolerated and is not of any risk to the patient.
mesh_terms: D001904:Botulinum Antitoxin / Q000627:therapeutic use*; D001906:Botulism / Q000175:diagnosis / Q000628:therapy*; D005602:France; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D013414:Sulfaguanidine / Q000627:therapeutic use*
chemical_list: D001904:Botulinum Antitoxin; D006146:Guanidines; D013414:Sulfaguanidine
vernacular_title: Le botulisme. Conduite thérapeutique. A propos de 36 cas