An animal model of fulminant hepatic failure in the rat.
A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic injury and brain edema resembled human fulminant hepatic failure. This model would facilitate further studies of the pathogenesis of brain dysfunction and evaluation of treatment in fulminant hepatic failure.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001921:Brain / Q000503:physiopathology; D001923:Brain Chemistry; D001929:Brain Edema / Q000139:chemically induced / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D005688:Galactosamine; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000473:pathology; D008099:Liver / Q000032:analysis; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D051381:Rats
D000596:Amino Acids; D005688:Galactosamine