[Reactivity of the adrenals to ACTH in rats with alloxan diabetes].
Experiments were conducted on rats. A study was made of the adrenal gland ACTH reactivity under conditions of alloxan diabetes. The function of the adrenal gland increased one month after the administration of alloxan; this was indicated by an increase of their absolute and relative weight, by an elevation of the corticosterone content in the peripheral blood and the glands proper. ACTH stimulated the adrenal gland function in rats with an intact pancreas, increasing the weight of the adrenal glands, the level of corticosterones in the blood and the adrenal glands. ACTH reactivity proved to be lowered in rats with alloxan diabetes. The blood corticosterone level increased in them less and changes in the weight of the glands and of the hormone concentration in them proved to be statistically insignificant.
D000311:Adrenal Glands / Q000032:analysis / Q000187:drug effects / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000032:analysis / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D010912:Pituitary-Adrenal Function Tests; D051381:Rats
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Reaktivnost' nadpochechnikov k ADTG u krys s alloksanovym diabetom