Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes.
The nicotinamide analogue 6-aminonicotinamide and dibutyryl 3':5'-cAMP inhibit myogenesis in a clonal rat cell line from skeletal muscle. Both reagents produce a similar morphological response in the cells, and stimulate collagen and glycosaminoglycan synthesis. These data suggest that 6-aminonicotinamide and dibutyryl cAMP induce a phenotypic transformation of myogenic cells to cells that share many characteristics with chondrocytes.
D015120:6-Aminonicotinamide / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D002356:Cartilage / Q000166:cytology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000166:cytology* / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis; D009132:Muscles / Q000166:cytology*; D009243:NAD / Q000378:metabolism; D010641:Phenotype; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism
D006025:Glycosaminoglycans; D009243:NAD; D015120:6-Aminonicotinamide; D003994:Bucladesine; D003094:Collagen; D000242:Cyclic AMP; D011393:Procollagen-Proline Dioxygenase