Viruses harboured in blasts of the rat myelogenous leukemia (RBA-Le), induced by chicken sarcoma virus.
It was shown that the rat myelogenous leukemia RBA-Le harbours three kinds of viruses. 1. Rat leukemogenic virus, which can be recovered from leukemic cells, medium of cultured leukemic cells and the plasma of leukemic rats. About 12% of rats inoculated when newborn with the recovered virus developed leukemia. 2. Chicken sarcoma virus, which seems to have a lowered infectivity or altered host range as the B77(RBI) virus by which this leukemia had been induced. 3. A cytopathic, hemagglutinating virus, very pathogenic for baby rats, which was shown to be closely related, if not identical in biological as well as immunological properties with Kilham rat virus. The RBA-Le leukemic cells were adapted for growth in tissue culture.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000302:isolation & purification*; D002467:Cell Nucleus / Q000473:pathology; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D003588:Cytopathogenic Effect, Viral; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006518:Hepatitis Viruses / Q000302:isolation & purification; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D007942:Leukemia, Experimental / Q000382:microbiology*; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D051381:Rats; D012190:Retroviridae / Q000302:isolation & purification*