Carcinoma associated with irradiation of the immature breast.
In two women who had undergone radiation therapy at ages one and eleven years, respectively, carcinoma in a hypoplastic breast developed. Each patient was treated by radical mastectomy. One patient is presently being followed without evidence of metastases; the other died of sarcoidosis following thoracotomy. A history of irradiation, hypoplasia and microscopic findings compatible with radiation changes suggests that these two cases of carcinoma may be radiation-induced.
D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology; D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*