Sindbis virus inhibits phosphatidylcholine biosynthesis in BHK-21 cells.
Sindbis virus inhibits the incorporation of [methyl-3H]choline into the phospholipids of BHK-21 cells and also inhibits the activity of the enzyme that catalyzes the final reaction involved in phosphatidylcholine biosynthesis (cytidine diphosphate-choline:1,2-diacylglycerol cholinephosphotranferase; EC 2.7.8.2).
D002460:Cell Line; D002794:Choline / Q000378:metabolism; D002798:Diacylglycerol Cholinephosphotransferase / Q000378:metabolism; D007106:Immune Sera; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D012672:Semliki forest virus / Q000254:growth & development / Q000276:immunology; D012845:Sindbis Virus / Q000254:growth & development* / Q000276:immunology
D007106:Immune Sera; D010713:Phosphatidylcholines; D002798:Diacylglycerol Cholinephosphotransferase; D002794:Choline