title: Esterase-6 (Es-6) in laboratory mice: hormone-influenced expression and linkage relationship to oligosyndactylism (Os), esterase-1 (Es-1), and esterase-2 (Es-2) in chromosome 8.
abstract: Allelic differences at an esterase locus designated Es-6 exist between mouse strain C57 BL/6J and a laboratory stock of M.m. molossinus. Strain C57BL/6J has been assigned the allele Es-6a and M. m. molossinus the alternate allele Es-6b. Kidney expression of the electrophoretic esterase band controlled by the Es-6 locus is sex influenced, with increased activity apparently induced by testosterone. A four-point test cross established the gene order Os-Es-1-Es-6-Es-2 within a 10-cM segment on chromosome 8.
mesh_terms: D000483:Alleles; D000818:Animals; D002369:Castration; D002874:Chromosome Mapping; D004950:Esterases / Q000096:biosynthesis*; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D007668:Kidney / Q000201:enzymology; D008297:Male; D051379:Mice / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D011110:Polymorphism, Genetic; D012723:Sex; D013576:Syndactyly / Q000235:genetics; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone; D004950:Esterases