Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites.
SV40 T antigen binds to SV40 DNA. Using a series of purified SV40 DNA restriction fragments, we have obtained evidence indicating that the antigen preferentially binds to three specific regions. These binding regions are contained within Endo R-Hin d(II + III) A, B, and C.
D000956:Antigens, Viral; D001665:Binding Sites; D002471:Cell Transformation, Neoplastic; D004262:DNA Restriction Enzymes; D004270:DNA, Circular / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism*; D009691:Nucleic Acid Denaturation; D013539:Simian virus 40 / Q000276:immunology*
D000956:Antigens, Viral; D004270:DNA, Circular; D004279:DNA, Viral; D004262:DNA Restriction Enzymes