Polymyxin B reactions, IgE antibody, and T-cell deficiency. Immunochemical studies in a patient after bone marrow transplantation.
A patient with aplastic anemia was immunosuppressed with cyclophosphamide and transplanted with allogenic bone marrow. While lacking demonstrable T-cell activity posttransplantation, he developed a generalized macular erythematous eruption and fever, clinically attributed to intranasal polymyxin B. A specific IgE antibody, demonstrated by direct skin testing, Prausnitz-Kustner passive transfer, and indirect passive hemagglutination was temporally related to the reaction. Discontinuation of the drug led to prompt defervescence and resolution of the drug eruption.
D000293:Adolescent; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002417:Cattle; D004342:Drug Hypersensitivity / Q000209:etiology; D004890:Erythema / Q000139:chemically induced* / Q000276:immunology; D005334:Fever / Q000139:chemically induced* / Q000276:immunology; D006384:Hemagglutination; D006433:Hemocyanins / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007958:Leukocyte Count; D008297:Male; D011113:Polymyxins / Q000009:adverse effects* / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012756:Sheep / Q000276:immunology; D012882:Skin Tests; D013601:T-Lymphocytes; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D011113:Polymyxins; D012710:Serum Albumin, Bovine; D007073:Immunoglobulin E; D006433:Hemocyanins