Cyclic amp concentration and enzyme activities of cerebrospinal fluid in patients with epilepsy or central nervous system damage.
Cyclic adenosine-3',5'-monophosphate (cAMP) concentration in cerebrospinal fluid (CSF) was measured by the protein binding method of Gilman from 62 neurological patients, 46 of them were epileptics and 16 with a central nervous system (CNS) damage. In epileptic patients the CSF concentration of cAMP was significantly elevated (p smaller than 0.02) for 3 days after an attack when compared with those free from attacks for at least 2 weeks. The causality relationship between the rise of cAMP in CSF and an epileptic discharge is discussed. In patient with an active or rapidly progressing CNS damage the cAMP levels in the CSF were significantly higher (p smaller than 0.001) than in those with an old CNS damage. Also some enzyme activities in CSF were measured but no uniform alterations could be found. In damaging processes of the CNS, the cAMP values in the CSF seem to correlate to the activity of the disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000134:cerebrospinal fluid; D001219:Aspartate Aminotransferases / Q000134:cerebrospinal fluid; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000201:enzymology; D003402:Creatine Kinase / Q000134:cerebrospinal fluid; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D004827:Epilepsy / Q000134:cerebrospinal fluid* / Q000201:enzymology; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid / Q000201:enzymology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D014166:Transferases / Q000134:cerebrospinal fluid*
D000242:Cyclic AMP; D007770:L-Lactate Dehydrogenase; D014166:Transferases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase