Experimentally induced respiratory syncytial viral infection in calves.
Calves exposed by intranasal (IN) or intratracheal (IT) or both routes of inoculation to bovine respiratory syncytial (BRS) virus had a transient increase in body temperature for 2 days. Histopathologic changes indicative of pneumonia, along with multinucleated giant cells, were observed in alveolar lumen. The virus was recovered from infected calves, and their serologic response was poor. In a limited serologic survey with 100 serums from cattle in Maryland, low levels of serum-neutralizing (SN) antibody to the virus were prevalent in 38% of the serums.
D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D001980:Bronchi / Q000382:microbiology; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011024:Pneumonia, Viral / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012136:Respiratory Syncytial Viruses / Q000276:immunology / Q000302:isolation & purification; D014132:Trachea
D000336:Aerosols