Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives.
A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive of focal nodular hyperplasia, while the remainder had the histological characteristics of a well-differentiated hepatocellular carcinoma. This is the first report of malignant transformation of a tumour in a patient taking oral contraceptives.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000009:adverse effects; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D008535:Megestrol / Q000009:adverse effects; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; D008535:Megestrol