Adenosine 3',5'-cyclic monophosphate and morphology in Neurospora crassa: drug-induced alterations.
Grown in liquid culture in the presence of a variety of structurally unrelated drugs, mycelia of wild-type Neurospora assume a colonial or semicolonial growth habit similar to that of known morphological mutants. Drugs that produce these morphological changes include atropine, theophylline, histamine, and several of the quinoline-containing antimalarials. Each of these drugs decrease the endogenous adenosine 3',5'-cyclic monophosphate (cAMP) concentration of mycelia as a result of their effect on the activity of adenyl cyclase, the cAMP-dependent phosphodiesterase, or both. The evidence indicates a relationship between the degree of morphological abnormality, the degree to which intracellular cAMP is reduced, and the action of the drugs on the adenyl cyclase and phosphodiesterase.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000962:Antimalarials / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D007700:Kinetics; D009491:Neurospora / Q000166:cytology*; D009492:Neurospora crassa / Q000166:cytology* / Q000201:enzymology / Q000254:growth & development; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011802:Quinidine / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology*
D000962:Antimalarials; D001285:Atropine; D006632:Histamine; D002738:Chloroquine; D011803:Quinine; D013806:Theophylline; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D011802:Quinidine