[Noncoenzymic function of vitamin PP].
The article deals with the experimental data of the authors and those from literature on interrelation between NAD and DNA metabolism in hepatocytes and the role of nuclear NAD-glycohydrolase and NAD-pyrophosphorylase in these processes. Considerable attention is paid to the information on biosynthesis, structure and biochemical functions of poly(ADPR)--a new polymer formed in eucariots nuclei from NAD. The data on the effects of vitamin PP and its biologically active derivative--NAD on DNA synthesis, proliferation of cells and on their genic activity are presented and discussed from modern view points on noncoenzymatic functions of this vitamin.
D000818:Animals; D004247:DNA / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009244:NAD+ Nucleosidase / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology*; D009713:Nucleotidyltransferases / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism
D009243:NAD; D009536:Niacinamide; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D009713:Nucleotidyltransferases; D009244:NAD+ Nucleosidase