Effect of lithium ions on RNA synthesis in mammary gland explants of mice.
LiC1 was found to stimulate RNA synthesis in the mammary gland in a manner similar to that of prolactin. Since LiC1 is known to inhibit adenyl cyclase and thus to reduce levels of cyclic AMP, it is concluded that a reduced level of cyclic AMP may be one step in the mechanism whereby prolactin regulates the metabolism of the mammary gland.
D000818:Animals; D046508:Culture Techniques; D006152:Cyclic GMP / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007477:Ions; D008094:Lithium / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D051379:Mice; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D013806:Theophylline / Q000494:pharmacology; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D007328:Insulin; D007477:Ions; D014316:Tritium; D012313:RNA; D011388:Prolactin; D008094:Lithium; D011803:Quinine; D013806:Theophylline; D006152:Cyclic GMP; D014529:Uridine; D006854:Hydrocortisone