[Studies on the antigenicity of synthetic ACTH (beta1-24-corticotropin) in normal subjects (author's transl)].
9 healthy volunteers were subjected to a 3-week treatment with synthetic ACTH. Antibody response against beta1-24-corticotropin (Synacthen) was tested by passive transfer in the Prausnitz-Küstner reaction, complement fixation, passive hemagglutination and agar-gel diffusion. Failure of the healthy persons to produce reaginic or non-reaginic antibodies is compared titerature.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000328:Adult; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens; D003366:Cosyntropin / Q000276:immunology* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007273:Injections, Intramuscular; D008297:Male; D011817:Rabbits / Q000276:immunology; D013997:Time Factors
D000941:Antigens; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone
Untersuchungen zur Antigenität von synthetischem ACTH (beta1-24-Corticotropin) bei freiwilligen Versuchspersonen