Formation of angiotensin III by angiotensin-converting enzyme.
Angiotensin III is formed from des-Asp1 -angiotensin I by angiotensin-converting enzyme. The Km (11 muM) of the reaction is one-third of that for the conversion of angiotensin I into angiotensin II. As suggested by the Km values, bradykinin, peptide BPP9a and angiotensins II and III are better inhibitors of the formation of angiotensin II than of the formation of angiotensin III.
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin / Q000494:pharmacology; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D012504:Saralasin / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D012504:Saralasin; D001920:Bradykinin