Toxicity of oxythioquinox in relation to the fat content of the diet: study of the metabolic activity of rat intestinal epithelium.
The relationship between the level of lipid calories in the diet and the effects of oxythioquinox, administered for 30 days at 200 mg/kg fresh food, was studied on the metabolism of enterocytes. The results show that the QO2, the QG and the QL of the enterocytes drop both, with the level of lipid intake and with the presence of oxythioquinox. The (Na+ + K+) ATPase, Mg+ +ATPase and arylamidase activities of a homogenate of enterocytes all increase both with the level of alimentary lipids and with the presence of oxythioquinox, the effect of oxythioquinox being potentialized by the lipids. Alkaline phosphatase was found to be the only enzyme to be inhibited in the treated animals and the lipid-oxythioquinox interaction moves in the direction of a decrease in this inhibition. For most of the investigated parameters, because of the interaction, as the level of lipid calories increases, the toxicity of oxythioquinox becomes noticeably modified.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004848:Epithelium / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010575:Pesticides / Q000378:metabolism / Q000633:toxicity*; D011810:Quinoxalines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats
D004041:Dietary Fats; D010575:Pesticides; D011810:Quinoxalines; C005266:quinomethionate; D000469:Alkaline Phosphatase; D000626:Aminopeptidases; D000251:Adenosine Triphosphatases