[General adaptation syndrome (Selye) in the calf. 5. Effect of increased glucocorticosteroid values on the phagocytosis activity of luekocytes, the function of RHS and the morphology of lymphatic organs].
Studies were conducted with the view to elucidating the correlations between increased glucocorticosteroid levels in the blood and the defense potential of calf organism against infectious diseases. The test animals were exposed to several substances (ACTH, cortisol, colibacteria, coliendotoxin), and even one to two days of increased 11-OHKS values were followed by marked decline in phagocytosis activity of leucocytes. In addition, RHS function was considerably reduced, after ten to thirteen days of application had elapsed, since at that point the disappearance of intravenously applied bacteria from circulating blood of test animals took place at rates which were much lower than those recorded from untreated calves. Differentiated length of stress or action (four to thirteen days) was followed by conspicuous changes in the lymphatic tissue of calf organism, with severe involution of thymus and follicular atrophy of intestine-associated lymphatic tissue having been the major findings. The results seem to suggest that rise in adrenocortical hormone level under stress may reduce potential organic defense to infection.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000097:blood; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism* / Q000473:pathology; D004731:Endotoxins / Q000008:administration & dosage; D004926:Escherichia coli; D005260:Female; D005790:General Adaptation Syndrome / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005938:Glucocorticoids / Q000097:blood*; D006854:Hydrocortisone / Q000008:administration & dosage; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D013312:Stress, Physiological / Q000662:veterinary*; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D015062:11-Hydroxycorticosteroids; D004731:Endotoxins; D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Allgemeines Adaptationssyndrom (Selye) bein Kalb 5. Einfluss erhöhter Glukokortikosteroidwerte auf die Phagozytoseaktivität von Leukozyten, die Funktion der RHS und die Morphologie lymphatischer Organe