title: The mechanism of lipid-binding by plasma lipoproteins.
abstract: In this article, we review the current state of knowledge about the structure of human plasma high density lipoproteins. Recent advances in this field, including amino acid sequencing and lipid-binding studies, suggest that the plasma lipoproteins have specific sites with special structural features that account for their ability to bind and transport lipid. A hypothesis which describes the structure of these lipid-binding sites and their interaction with lipid is presented.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001059:Apoproteins; D001665:Binding Sites; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D046911:Macromolecular Substances; D008958:Models, Molecular; D008970:Molecular Weight; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D011485:Protein Binding; D011487:Protein Conformation
chemical_list: D000596:Amino Acids; D001059:Apoproteins; D008075:Lipoproteins, HDL; D046911:Macromolecular Substances; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids