Exacerbation and reactivation of Herpesvirus hominis infection in mice by cyclophosphamide.
Cyclophosphamide has been shown to potentiate the growth of Herpesvirus hominis in the skin of Webster Schneider mice. Higher skin yields of virus were obtained, marked dissemination of virus to the brain was produced and mortality in mice was increased. Serum neutralizing antibody titres were suppressed. The system may serve as a good model for the study of specific antiherpes drugs.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain / Q000382:microbiology; D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D006224:Cricetinae; D003520:Cyclophosphamide / Q000009:adverse effects*; D003588:Cytopathogenic Effect, Viral; D004195:Disease Models, Animal; D006561:Herpes Simplex / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D006801:Humans; D007279:Injections, Subcutaneous; D007668:Kidney; D007822:Laryngeal Neoplasms; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D018139:Simplexvirus / Q000254:growth & development / Q000276:immunology; D012867:Skin / Q000382:microbiology; D014776:Virus Cultivation; D014779:Virus Replication
D000914:Antibodies, Viral; D003520:Cyclophosphamide