title: Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data.
abstract: A great number of earlier reported experimental data dealing with the role of dopamine in dopamine-loaded structures within the mammalian brain have raised questions concerning the concept of dopamine as an inhibitory agent acting on one type of receptor. A critical review of the anatomical, histochemical, electrophysiological, pharmacological and functional studies reveals that the dopamine-loaded structures are marked by an internal differentiation at various levels. It is attempted to demonstrate that this is due to a heterogeneous distribution of two distinct types of dopamine-receptors, each characterized by their own properties: DAe and DAi-receptors. Furthermore, the experimental and clinical implications are discussed in view of the hypothesis that balance between both types of receptors is essential for normal psychomotor functioning.
mesh_terms: D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D002415:Cats; D002421:Caudate Nucleus / Q000502:physiology; D003342:Corpus Striatum / Q000032:analysis; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004594:Electrophysiology; D004876:Ergot Alkaloids / Q000494:pharmacology; D006801:Humans; D009069:Movement Disorders / Q000378:metabolism; D009433:Neural Inhibition; D010891:Piribedil / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012686:Septal Nuclei / Q000032:analysis; D013378:Substantia Nigra / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D000662:Amphetamines; D004876:Ergot Alkaloids; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D005680:gamma-Aminobutyric Acid; D010891:Piribedil; D001058:Apomorphine; D004298:Dopamine