Effect of bacillus Calmette-Guérin immunization in marmosets infected experimentally with Herpesvirus saimiri.
Eight white-lipped marmosets immunized with BCG and 3 sham-immunized marmosets were studied after inoculation with Herpesvirus saimiri (HVS). BCG immunization had no significant influence on the incidence of infection by HVS, incidence of fatal malignant lymphoma, time of leukemia onset, development or titer of HVS antibodies, or average survival time. One BCG-immunized, HVS-infected marmoset failed to develop malignant lymphoma, whereas the remaining 10 HVS-infected marmosets died of malignant lymphoma. Prolonged survival occurred also in 1 marmoset immunized with BCG 100 days after HVS inoculation. The development and disappearance of lymphocyte reactivity to tuberculin were followed in 4 BCG-immunized marmosets.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001500:BCG Vaccine; D002143:Callitrichinae; D006564:Herpesviridae; D006566:Herpesviridae Infections / Q000276:immunology*; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology; D006968:Hypersensitivity, Delayed; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000209:etiology / Q000276:immunology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology; D014374:Tuberculin Test
D000914:Antibodies, Viral; D001500:BCG Vaccine