[Binding of delta-8-THC to human serum proteins: binding as a function of lipoprotein composition].
In accordance with the function of the human lipoprotein composition, using serum of different lipid profiles, the distribution of delta8tetrahydrocannabinol, as isomer of delta9THC, was studied through the use of ultracentrifugation and fraction isolation, followed by biochemical analysis of the VLDL, LDL, and HDL fractions, as well as that of the non-lipoprotein protein fraction. The results indicate the existence of a linear correlation between the distribution of delta8THC and the phospholipids of the lipoprotein cenapse. No correlation between the quantity of bound delta8THC and the other lipoprotein constituents cholesterol, triglycerides, total lipids or protein could be observed.
D001798:Blood Proteins / Q000378:metabolism*; D002188:Cannabis / Q000378:metabolism*; D013759:Dronabinol / Q000138:chemical synthesis / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000302:isolation & purification / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D011485:Protein Binding
D001798:Blood Proteins; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D013759:Dronabinol
Liaison du delta8-THC aux protéines sériques humaines: étude de sa fixation en fonction de la composition lipoprotéinique