Effect of hydratation on renal water and sodium excretion in patients with renal arterial stenosis (S) and essential hypertension (EH).
Water and electrolyte excretion after a large water load and a small Na load was studied in a group of healthy volunteers (C) and in patients with renal arterial stenosis (S) and essential hypertension (EH). It was found that both groups of hypertensive patients reacted to this stimulus by higher Na, Cl, Ca and Mg excretion tan group C. In the two hypertension groups, cumulative Na excretion was comparable in size, but cumulative water excretion was significantly greater in group EH than in group S. The results indicate that these differences can be attributed to different localization of reduced Na reabsorption in the nephron. Signs of a decrease in Na resorption were found in the distal part of the nephron in both hypertension groups, but in the EH group they were also found in the proximal part.
D002712:Chlorides / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000652:urine*; D008297:Male; D012078:Renal Artery Obstruction / Q000150:complications / Q000652:urine*; D012964:Sodium / Q000652:urine*; D014867:Water / Q000378:metabolism*
D002712:Chlorides; D014867:Water; D012964:Sodium