title: Relationship between elongation factor I- and elongation factor II- dependent guanosine triphosphatase activities of ribosomes. Inhibition of both activities by ricin.
abstract: The elongation factor 1- and elongation factor 2-dependent GTPase (guanosine triphosphatase) activities of ribosomes are inhibited by ricin, a toxic protein known to inactivate the 60S ribosomal subunit. It is suggested that also in eukaryotic ribosomes a "GTPase site', located on the larger subunit, is common to the two elongation factors.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D020963:GTP Phosphohydrolase-Linked Elongation Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D010445:Peptide Elongation Factors; D010649:Phenylalanine; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010940:Plant Proteins / Q000494:pharmacology*; D012343:RNA, Transfer; D051381:Rats; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism; D012276:Ricin / Q000494:pharmacology*
chemical_list: D010445:Peptide Elongation Factors; D010940:Plant Proteins; D010649:Phenylalanine; D012276:Ricin; D012343:RNA, Transfer; D010744:Phosphoric Monoester Hydrolases; D020963:GTP Phosphohydrolase-Linked Elongation Factors