[Plasma ACTH and Nelson tumors in bilaterally adrenalectomized Cushing patients].
Bilaterally adrenalectomized patients (18) because of Cushing's syndrome were studied. 16 of these 18 persons exhibited fairly high plasma ACTH levels. Distinctly elevated plasma ACTH levels were observed in 6 of them. 5 patients of this group showed an enlarged sella and deep pigmentation of the skin. 4 of the latter group had a mucoid cell adenoma which was removed selectively. After the surgery the ACTH values were found to be within normal range without any significant endocrine dysfunction of the pituitary. A long-term ACTH survey revealed that the ACTH levels remained within the ranges of bilaterally adrenalectomized Cushing patients without concomitant enlargement of the sella or pigmentation.
D000236:Adenoma / Q000097:blood* / Q000209:etiology / Q000601:surgery; D000315:Adrenalectomy / Q000009:adverse effects*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000818:Animals; D003480:Cushing Syndrome / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000209:etiology; D010911:Pituitary Neoplasms / Q000097:blood* / Q000209:etiology / Q000601:surgery; D051381:Rats; D012658:Sella Turcica / Q000473:pathology; D013577:Syndrome
D000324:Adrenocorticotropic Hormone
Plasma-ACTH und Nelson-Tumoren bei bilateral adrenalektomierten Cushing-Patienten