Specificity of the effect of dietary cholesterol on rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase activity.
Dietary cholesterol lowers the activity of rat liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase without affecting various other liver microsomal enzymes. This is consistent with a specific regulatory mechanism and distinguishes the action of cholesterol on 3-hydroxy-3-methylglutaryl-CoA reductase from that of at least one other stimulus known to affect this enzyme.
D000284:Administration, Oral; D000429:Alcohol Oxidoreductases / Q000032:analysis*; D000818:Animals; D001835:Body Weight; D002791:Cholesterol, Dietary / Q000378:metabolism*; D005260:Female; D005952:Glucose-6-Phosphatase / Q000032:analysis; D006903:Hydroxymethylglutaryl CoA Reductases / Q000032:analysis*; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis; D051381:Rats
D002791:Cholesterol, Dietary; D000429:Alcohol Oxidoreductases; D006903:Hydroxymethylglutaryl CoA Reductases; D009247:NADH, NADPH Oxidoreductases; D005952:Glucose-6-Phosphatase