[Role of bioenergetic changes in the mechanism of action of nonsteroid anti-inflammatory agents].
In experiments on rats the antiphlogistic action of sodium mephenaminate and salicylate was found to be more pronounced under conditions of ovalbumin than that of dextran inflammation. The antiphlogistic effect of sodium salicylate was greater than that of mephenaminate in ovalbumin inflammation; this correlated with a more marked drop in the content of lactic acid in the blood and with a more complete elimination of uncoupling of oxidative phosphorylation in the hepatic mitochondria than in case of mephenaminate injection. It is supposed that lowering the macroerg level by the principle of feed back action leads to intensification of phosphorylation; this provides elimination of inflammatory disturbances and can explain the antiphlogistic effect of the drugs.
D000244:Adenosine Diphosphate / Q000097:blood; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003911:Dextrans; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D007773:Lactates / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008528:Mefenamic Acid / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010047:Ovalbumin; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010758:Phosphorus / Q000097:blood; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D003911:Dextrans; D007773:Lactates; D009243:NAD; D010758:Phosphorus; D008528:Mefenamic Acid; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010047:Ovalbumin; D000251:Adenosine Triphosphatases; D012980:Sodium Salicylate
Rol' izmeneniĭ bioénergetiki v mekhanizme deĭstviia nesteroidnykh protivovospalitel'nykh preparatov