title: Circulating immune complexes in acute uveitis: a possible association with the histocompatibility complex locus antigen B27.
abstract: 39 patients with acute anterior uveitis were investigated for the presence of circulating immune complex (IC) and correlation with the major histocompatibility complex antigen B27 (HLA-B27). ICs were demonstrated by a number of techniques including rheumatoid factor, complement (C) activation, anticomplementary activity, cryoglobulins, inhibition of IgG-EA rosette formation and neutrophil chemotactic index (NCI) in plasma. ICs were most frequently detected in HLA-B27-negative patients. These results indicate that deposition of circulating ICs may be involved in the pathogenesis of acute anterior uveitis, especially in HLA-B27-negative patients.
mesh_terms: D000208:Acute Disease; D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins / Q000276:immunology; D003450:Cryoglobulins; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications* / Q000276:immunology; D008297:Male; D011947:Receptors, Antigen, B-Cell; D012217:Rheumatoid Factor; D014605:Uveitis / Q000150:complications* / Q000276:immunology
chemical_list: D003176:Complement C3; D003181:Complement C4; D003450:Cryoglobulins; D006680:HLA Antigens; D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins; D012217:Rheumatoid Factor