Appearance of growth-inhibiting activity (G1 chalone) during ontogenetic development of rat and chick epidermis in vivo and in vitro.
A comparative study was carried out between the stage of embryonic development of epidermis and its content of growth-inhibitory activity (G1 chalone). Injections of aqueous extracts from keratinized fetal rat or chick embryo epidermis led to a depression of DNA-synthesis in adult mouse epidermis, whereas extracts from undifferentiated epidermis did not contain such an activity.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D005333:Fetus; D006131:Growth Inhibitors / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000196:embryology / Q000378:metabolism*
D006131:Growth Inhibitors