Insulin binding to cultured human fibroblasts increases with normal and precocious aging.
Specific and nonspecific [125I]insulin binding and concentration of unlabeled hormone producing 50 percent competition with 1.0 nanomolar [125I]insulin for specific binding sites correlated positively with age of fibroblast donors. Cells from four children with precocious aging--three with progeria and one with Rothmund syndrome-resembled those from the chronologically old.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001665:Binding Sites; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005347:Fibroblasts; D006801:Humans; D007223:Infant; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics; D008875:Middle Aged; D011371:Progeria / Q000378:metabolism; D011956:Receptors, Cell Surface
D007328:Insulin; D011956:Receptors, Cell Surface