[Modern views on mechanism of ATP hydrolysis by myosin (on the 40th anniversary of myosin enzymatic activity discovery)].
Literature data and the author's materials concerning the intermediate stages of ATP hydrolysis by myosin and actomyosin are reviewed. The scheme of hydrolytic stages based on the application of fluorescent and UV spectroscopic stop-flow and 18O exchange methods is discussed. Some unsolved problems of the hydrolytic mechanism and its relation to energy transduction in the mechanochemical act are also considered.
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D006868:Hydrolysis; D007553:Isotope Labeling / Q000379:methods; D009218:Myosins / Q000378:metabolism*; D010103:Oxygen Isotopes; D013050:Spectrometry, Fluorescence / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D010103:Oxygen Isotopes; D000255:Adenosine Triphosphate; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D009218:Myosins
Sovremennye predstavleniia o mekhanizme gidroliza ATP miozinom (k 40-letiiu otkrytiia fermentativnykh svoĭstv miozina).