The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Male rats have a greater microsomal amidopyrine N-demethylase activity per unit weight of liver, a shorter hexobarbitone sleeping time and are more susceptible to the hepatotoxic effect of chloroform than female rats. Phenobarbitone sodium, phenylbutazone and DDT induce microsomal amidopyrine N-demethylase in the liver of the male rat and reduce hexobarbitone sleeping time. Chlorpromazine is less effective in this respect. Phenobarbitone, phenylbutazone and, to a lesser extent, chlorpromazine potentiate the hepatotoxic effect of chloroform in male rats. SKF 525A, sodium diethyl-dithiocarbamate and carbon disulphide increase hexabarbitone sleeping time in male rats and protect to varying degrees against the hepatotoxic effect of chloroform.
D000818:Animals; D002246:Carbon Disulfide / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D002725:Chloroform / Q000633:toxicity*; D002746:Chlorpromazine / Q000494:pharmacology; D003634:DDT / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004347:Drug Interactions; D004790:Enzyme Induction; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects
D002725:Chloroform; D004050:Ditiocarb; D011335:Proadifen; D006591:Hexobarbital; D003634:DDT; D006899:Mixed Function Oxygenases; D010089:Oxidoreductases, N-Demethylating; D010653:Phenylbutazone; D002246:Carbon Disulfide; D002746:Chlorpromazine; D010634:Phenobarbital