title: Induction of neural differentiation in cultures of amphibian undetermined presumptive epidermis by cyclic AMP derivatives.
abstract: Induction of neural differentiation in cultures of undetermined presumptive epidermis from three amphibian species was achieved by the addition of 1 millimolar dibutyryl adenosine 3',5'-monophosphate, 8-bromadenosine 3',5'-monophosphate, or adenosine C',E'-monophosphate together with theophylline. Adenosine 5'-monophosphate, adenosine 2',3'-monophosphate, dibutyryl guanosine 3',5'-monophosphate, and butyrate at 1 millimolar are ineffective. These results suggest that the action of the primary inductor or inductors may be mediated via adenosine 3',5'-monophosphate.
mesh_terms: D000663:Amphibians / Q000196:embryology*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D000242:Cyclic AMP / Q000031:analogs & derivatives*; D009474:Neurons / Q000166:cytology*; D012867:Skin / Q000196:embryology / Q000294:innervation; D014981:Xenopus / Q000196:embryology
chemical_list: D003994:Bucladesine; D000242:Cyclic AMP