Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants.
Respiratory syncytial virus ts-1 is a live attenuated experimental vaccine which was administered intranasally to 25 infants 11 to 19 months of age. Clinical evaluation was carried out following a controlled, double-blind protocol which eliminated observer bias, assessed intercurrent illness, and was designed to detect virus transmission. At the low dose of virus of virus used (100 TCID50) 8 of the 25 recipients were successfully infected with RS virus ts-1 as determined by virus shedding or antibody response.
D000914:Antibodies, Viral / Q000032:analysis; D006801:Humans; D007223:Infant; D009976:Orthomyxoviridae Infections / Q000517:prevention & control; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000517:prevention & control; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines