title: Hydrosoluble immunostimulants of bacterial and synthetic origins.
abstract: The role of whole Mycobacteria, mycobacterial cell walls and waxes D as immunostimulants was well established many years ago. More recently three different research groups have shown that hydrosoluble components from mycobacterial and other bacterial origins were as active as waxes D or cell walls and were free of many side-effects. Studies concerning the relationship between structure and activity were achieved which led to the description of a small biologically active fragment and to a first series of synthetic compounds.
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000302:isolation & purification*; D000818:Animals; D001419:Bacteria / Q000276:immunology; D002473:Cell Wall / Q000032:analysis / Q000276:immunology; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000517:prevention & control; D005620:Freund's Adjuvant; D006020:Glycopeptides / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D008970:Molecular Weight; D009161:Mycobacterium / Q000276:immunology*; D010455:Peptides / Q000302:isolation & purification; D010457:Peptidoglycan / Q000032:analysis; D011425:Propionibacterium acnes / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014885:Waxes / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D010455:Peptides; D010457:Peptidoglycan; D014885:Waxes; D005620:Freund's Adjuvant