[An electron microscopic and morphometric study of the gastric parietal cells of rats following administration of gastrin, histamine and cyclic 3',5'-adenosine monophosphate].
The ultrastructure of the gastric parietal cells was studied in rats affected by a genetic inductor of the hydrochloric acid secretion and its mediators in this process - histamine and cyclic 3', 5'-adenozinemonophosphate playing the role of the enzyme activators. All these stimulators caused similar changes in the cell structure. The square surface of the intracellular secretory tubules was shown to become 2,5 times larger, and that of the canaliculi - vesiculoid elements which seemed to be the cell membrane depot became 2,5 times less. It may be supposed that the gastric mucosa parietal cells are not the target-cells for pentagastrine (gastrine).
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D005755:Gastrins / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
D005755:Gastrins; D006632:Histamine; D000242:Cyclic AMP
Elektronnomikroskopicheskoe i morfometricheskoe izuchenie obkladochnykh kletok zheludka krys pri vvedenii gastrina, gistamina i tsiklicheskogo 3',5'-adenozinmonofosfata