Toxic and reactogenic properties of pertussis bacteria (experimental and clinical studies).
The results of the study revealed correlation between the reactogenicity of pertussis vaccines in epidemiological observations and the toxic properties of pertussis bacteria in experiment. Quantitative and qualitative differences were found between the toxic factors in pertussis bacteria depending on their type-specific serological activity. Serotype 1.0.3 microbes exhibit more pronounced toxicity which accounts for the greater reactogenicity of vaccines prepared from this serotype as compared with the preparation produced from the serotype 1.2.3. The obtained results suggest the necessity of considering the greater toxicity of the serotype 1.0.3 in the preparation of pertussis vaccines.
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001886:Bordetella pertussis / Q000378:metabolism / Q000472:pathogenicity*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007223:Infant; D007928:Lethal Dose 50; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D010567:Pertussis Vaccine / Q000633:toxicity*; D013045:Species Specificity; D014118:Toxins, Biological / Q000096:biosynthesis / Q000633:toxicity; D014611:Vaccination / Q000009:adverse effects*
D010567:Pertussis Vaccine; D014118:Toxins, Biological