[The effect of an ionophore on the aggregation of Dictyostelium discoideum].
Treatment during starvation of D. discoideum amoebae with micromolar amounts of A23187 causes an enhanced aggregation. Cells develop the properties of differentiated, aggregation competent amoebae earlier than untreated populations. Ionophore increases the release of calcium, and prevents the excretion of the phosphodiesterase ihibitor normally released in the media. A23187 suppresses the morphogenetic block of some aggregates mutants, suggesting that the ionophore either activates cAMP synthesis and excretion, or increases the cellular sensitivity to extracellular cAMP signals. This might result from the enhanced mobilisation of intracellular calcium
D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002449:Cell Aggregation / Q000187:drug effects; D004023:Dictyostelium / Q000166:cytology* / Q000201:enzymology; D004492:Edetic Acid / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology*; D007832:Lasalocid; D009154:Mutation; D009235:Myxomycetes / Q000166:cytology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism
D007476:Ionophores; D000001:Calcimycin; D004492:Edetic Acid; D010727:Phosphoric Diester Hydrolases; D002118:Calcium; D007832:Lasalocid
Effet d'un ionphore sur l'agrégation de Dictyostelium discoideum