Dopamine-sensitive adenylate cyclase occurs in a region of substantia nigra containing dopaminergic dendrites.
The zona reticulata, the subdivision of the substantia nigra containing dendrites of the dopaminergic nigro-neostriatal neurons, contains dopamine-sensitive adenylate cyclase activity. This nigral dopamine receptor is similar to the striatal dopamine receptor. These and previous data suggest a physiological role (or roles) for dopamine in the substantia nigra.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003712:Dendrites / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D004789:Enzyme Activation; D006892:Hydroxydopamines / Q000494:pharmacology; D007545:Isoproterenol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013378:Substantia Nigra / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
D018492:Dopamine Antagonists; D006892:Hydroxydopamines; D017981:Receptors, Neurotransmitter; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D002746:Chlorpromazine; D004298:Dopamine; D009638:Norepinephrine