[Reduction of radiation-induced late effects on vascular connective tissue of the skin (mouse paw) by o-(beta-hydroxyethyl)-rutoside].
The induction of irreversible late effects of the skin after irradiation of the mouse foot with and without i.p. HR-application has been investigated. The high protective effect of HR could be demonstrated which prevents grave late damage such as loss of toes. One single application of 300 mg/HR 0,5 h before irradiation has been optimally successful. Beside the excellent compatibility of even high doses, HR seems to have the advantage to be a selective radiation protection substance with a protective effect only for healthy cells (in this case presumably the vascular systems) and no effect on malignant cells. The possible mechanism of the stabilization of oxidative phosphorylation by flavonoids and a depression of glycolysis in malignant cells will be discussed.
D000818:Animals; D001808:Blood Vessels / Q000528:radiation effects*; D003238:Connective Tissue / Q000528:radiation effects*; D006614:Hindlimb; D006896:Hydroxyethylrutoside / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D012431:Rutin / Q000031:analogs & derivatives*; D013997:Time Factors
D006896:Hydroxyethylrutoside; D011837:Radiation-Protective Agents; D012431:Rutin
Verhinderung von strahleninduzierten Spätschäden des Gefäss-Bindegewebs-Systems der Haut (Mauspfote) durch O-(beta-Hydroxyäthyl)-rutoside.