Tumor-selective inhibition of the incorporation of 3H-labeled amino acids into protein by cyanate.
Sodium cyanate at a dose level of 125 or 250 mg/kg i.p. caused an inhibition of incorporation of 3H-labeled amino acids into cytoplasmic and nuclear proteins of the rapidly growing hepatoma 7777 and the slowly growing hepatoma 9618A. There was no inhibitory effect on 3H-labeled amino acid incorporation into protein in the livers of rats bearing these tumors. Studies on the effects of sodium cyanate on incorporation of 3H-labeled amino acids into total acid-insoluble material indicated that a greater than 85% inhibition could be achieved in hepatoma 5123C, hepatoma 9618A2, and the MK3 kidney tumor with either little or no effect in host liver, kidneys, brain, skeletal muscle, intestinal mucosa, and regenerating liver after partial hepatectomy.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D003485:Cyanates / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006498:Hepatectomy; D007413:Intestinal Mucosa / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D009132:Muscles / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000378:metabolism; D009698:Nucleoproteins / Q000096:biosynthesis; D051381:Rats; D014316:Tritium
D000596:Amino Acids; D003485:Cyanates; D009363:Neoplasm Proteins; D009698:Nucleoproteins; D014316:Tritium