title: [The mutagenic effect of methyl methanesulfonate (MMS) in vitro and in the host-mediated assay (author's transl)].
abstract: The concentration- and time-dependent genetic activity of methyl methanesulfonate (MMS) was investigated in vitro and in the host-mediated assay using four different indicator organisms. Dose/effect curves achieved with the different indicator organisms are similar.
mesh_terms: D000818:Animals; D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005821:Genetic Techniques; D066298:In Vitro Techniques; D008297:Male; D008698:Mesylates / Q000494:pharmacology*; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D013997:Time Factors
chemical_list: D008698:Mesylates; D008741:Methyl Methanesulfonate
vernacular_title: Uber die mutagene Wirkung des Methylmethansulfonats (MMS) in vitro und im "Host-Mediated Assay"