Immunopathology of mouse hepatitis virus type 3 infection. Role of humoral and cell-mediated immunity in resistance mechanisms.
Humoral and cell-mediated immune responses were studied in resistant and susceptible strains of mice infected with mouse hepatitis virus type III (MHV 3). Virus was maintained by regular passages in susceptible DBA/2 mice and assayed in DBA/2 mice by LD-50 determination. Normal resistant A strain mice were able to clear the virus from liver, brain, and serum within 7 days after infection. No neutralizing antibody was found. Transfer of serum from immunized A strain mice was not effective in protecting susceptible DBA/2 mice against challenge with virus. In A strain animals resistance to MHV-3 developed rapidly during the 3rd week of life. During the period of susceptibility, newborns were protected neither by transplacental passages of anti-MHV-3 antibodies nor by injection of "educated" thymus cells.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D001921:Brain / Q000382:microbiology; D006520:Hepatitis, Animal / Q000382:microbiology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D006517:Murine hepatitis virus / Q000276:immunology* / Q000302:isolation & purification; D009500:Neutralization Tests; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D014765:Viral Vaccines / Q000302:isolation & purification
D000914:Antibodies, Viral; D014765:Viral Vaccines