Effect of ammonium 5-tungsto-2-antimoniate on encephalomyocarditis and vesicular stomatitis virus infections in mice.
Ammonium 5-tungsto-2-antimoniate (HPA 23) protected micr partially or completely against two strains of encephalomyocarditis (EMC) virus and one strain of vesicular stomatitis (VSV) virus. The best protective effect was obtained with EMC strain VR 129 and VSV when a single i.p. injection of HPA 23 was administered shortly before virus inoculation. Mice protected by HPA 23 against EMC strain VR129 had virus titres in the blood and brain similar to those in untreated mice. A synergism between interferon and HPA 23 was observed in mice infected with EMC VR129. Our results demonstrate the in vivo activity of HPA 23 against two lethal viral infections and suggest that, at least in mice infected with EMC, death may not be related solely to virus multiplication.
D000818:Animals; D000965:Antimony / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity; D001769:Blood / Q000382:microbiology; D001921:Brain / Q000382:microbiology; D004357:Drug Synergism; D004686:Encephalomyocarditis virus / Q000187:drug effects / Q000254:growth & development; D004769:Enterovirus Infections / Q000517:prevention & control*; D005260:Female; D007274:Injections, Intraperitoneal; D007372:Interferons / Q000627:therapeutic use; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014414:Tungsten / Q000627:therapeutic use* / Q000633:toxicity; D017973:Tungsten Compounds; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000517:prevention & control*; D014779:Virus Replication
D000998:Antiviral Agents; D017973:Tungsten Compounds; C009613:ammonium tungsten antimonate hydroxide oxide; D007372:Interferons; D000965:Antimony; D014414:Tungsten