The stimulation of growth hormone release by ACTH and its inhibition by somatostatin.
The rapid injection of 0.5 or 1.0 mg of tetracosacitid (Synacthen¿) was followed by a distinct increase of plasma growth hormone (GH) within 30 or 45 min in 5 of 7 normal volunteers. A second control test was performed in 3 of the 5 "responders" and 1 "non-responder" and showed a consistent reaction in all of them. The tests were then repeated in the 5 "responders" during an infusion of somatostatin (150 mug/h) and the GH response was totally abolished (3 subjects) or markedly reduced (2 subjects). Thus the ACTH induced GH release behaves in a manner similar to most other physiological or pharmacological stimuli of GH release. The cortisol output after ACTH was not altered by somatostatin.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000328:Adult; D003366:Cosyntropin / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D003366:Cosyntropin; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone