Further study on the effects of LH-RH in rat anterior pituitary.
As to the mechanism of the action of LH-RH on rat anterior pituitary, the participation of the adenylate cyclase system in gonadotropin release has been clarified. The authors previously reported that LH-RH increased the RNA synthesis in the rat anterior pituitary. In this study, the significance of the increase of RNA synthesis by LH-RH and the relationship between the adenylate cyclase system and the RNA synthesis system were investigated and the following results were obtained. (1) LH-RH induces not only the release of LH but also its synthesis in the rat anterior pituitary, and furthermore, RNA synthesis participates in LH synthesis. (2) The effects of LH-RH on RNA synthesis appeared to be independent from the effects on the adenylate cyclase system.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000096:biosynthesis / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014529:Uridine / Q000378:metabolism
D007987:Gonadotropin-Releasing Hormone; D012313:RNA; D003994:Bucladesine; D007986:Luteinizing Hormone; D000262:Adenylyl Cyclases; D014529:Uridine