title: Coordinate regulation of adenylate cyclase and carbohydrate permeases by the phosphoenolpyruvate:sugar phosphotransferase system in Salmonella typhimurium.
abstract: Adenylate cyclase (EC 4.6.1.1) and several carbohydrate permeases are inhibited by D-glucose and other substrates of the phosphoenolpyruvate:sugar phosphotransferase system. These activities are coordinately altered by sugar substrates of the phosphotransferase system in a variety of bacterial strains which contain differing cellular levels of the protein components of the phosphotransferase system: Enzyme I, a small heat-stable protein, and Enzyme II. It is suggested that the activities of adenylate cyclase and the permease proteins are subject to allosteric regulation and that the allosteric effector is a regulatory protein which can be phosphorylated by the phosphotransferase system.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D002241:Carbohydrates; D000242:Cyclic AMP / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism; D007700:Kinetics; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008757:Methylglucosides / Q000494:pharmacology; D010728:Phosphoenolpyruvate; D010770:Phosphotransferases / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000201:enzymology*
chemical_list: D002241:Carbohydrates; D026901:Membrane Transport Proteins; D008757:Methylglucosides; D010728:Phosphoenolpyruvate; D000242:Cyclic AMP; D010770:Phosphotransferases; D000262:Adenylyl Cyclases; D005947:Glucose; D005990:Glycerol