X chromosome-linked defect of CBA/HN mice in production of tumor-reactive naturally occurring IgM antibodies.
Tumor-reactive naturally occurring antibodies (NOA) could be readily detected in sera of many mouse strains including congenitally athymic (nude) and germ free (gf) mice. Mice of the CBA/HN strain, however, were found to possess low or undetectable levels of NOA against a wide range of tumor cell lines. Genetic studies indicated that the defect in production of tumor-reactive NOA in CBA/HN mice was largely determined by the absence of an X chromosome-linked gene and is probably similar to the known X chromosome defect of this mouse strain in their antibody response to thymus-independent antigens. In spite of the low level of tumor-reactive NOA, CBA/HN mice do not have a high incidence of spontaneous tumors. These findings suggest that if tumor reactive NOA are involved in immune surveillance against malignancy they are unlikely to act directly in a quantitative manner in the detection and elimination of autochthonous tumors.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm / Q000032:analysis*; D002460:Cell Line; D002845:Chromatography; D003433:Crosses, Genetic; D046508:Culture Techniques; D003601:Cytotoxicity Tests, Immunologic; D003911:Dextrans; D005909:Glioblastoma / Q000276:immunology; D007125:Immunogenetics; D007075:Immunoglobulin M / Q000032:analysis*; D007518:Isoantibodies / Q000032:analysis*; D007942:Leukemia, Experimental / Q000276:immunology; D008623:Mercaptoethanol; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA / Q000276:immunology*; D009447:Neuroblastoma / Q000276:immunology; D012730:Sex Chromosomes; D013724:Teratoma / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm; D003911:Dextrans; D007075:Immunoglobulin M; D007518:Isoantibodies; D008623:Mercaptoethanol