Host-range properties of murine xenotropic and ecotropic type-C viruses.
Host-range properties of xenotropic (x-tropic) and ecotropic mouse type-C viruses were determined. NB-tropic viruses replicated only in mouse and rat cells, whereas x-tropic viruses, which do not exogenously infect mouse cells, grew in cells from various other mammalian species. Great variability in susceptibilities to x-tropic viruses was demonstrated in cells from heterologous species and in cells from a single species (human). Although rat cells were susceptible to both types of viruses, hamster cells were uniformly resistant. In addition, the x-tropic viruses crossed class barriers to infect cells of avian species but not insect, fish, or reptile cells.
D000818:Animals; D001717:Birds; D002478:Cells, Cultured; D007313:Insecta; D008322:Mammals; D051379:Mice; D051381:Rats; D012104:Reptiles; D012190:Retroviridae / Q000254:growth & development*; D013045:Species Specificity; D014779:Virus Replication