[Changes in the functional state and structure of the adrenals in CC14 poisoning].
Introduction of CCI4 in doses of 0.1 and 0.2 ml/100 g to albino rats reduced the steroid production generated by adrenal sections. In 24 and 48 hours after poisoning with a small dose of CCI4 (0.1 ml/100 g) there could be seen an increased concentration of 11-oxycorticosteroids in the plasma. Morphological signs of a damage suffered by the gland were observed only in poisoning with a large dose of CCI4 (0.2 ml/100 g).
D015062:11-Hydroxycorticosteroids / Q000096:biosynthesis / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology*; D003900:Desoxycorticosterone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects; D008297:Male; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D003900:Desoxycorticosterone; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D002251:Carbon Tetrachloride
Izmeneniia funktsional'nogo sostoianiia i struktury nadpochechnikov pri intoksikatsii CC14