[Ways of drug action on the restorative processes in the myocardium in experimental myocardial infarct].
On a model of experimental myocardial infarction there is demonstrated the stimulating effect of inosine (most distinctly) and also of stimulants of the nucleic acids synthesis and of retabolil on the formation of the post-infarction scar, the processes of compensatory hyperfunction and hypertrophy, all this finally speeding up the restoration of the myocardial function as a whole. At the root of this research carried out on 276 rabbits there lie histological, histochemical, electron microscopic, biochemical, electrographic findings and determination of the intracardiac hemodynamics.
D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D004950:Esterases / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D007288:Inosine / Q000494:pharmacology; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009696:Nucleic Acids / Q000096:biosynthesis; D009963:Orotic Acid / Q000494:pharmacology; D010088:Oxidoreductases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011817:Rabbits; D013268:Stimulation, Chemical; D014805:Vitamin B 12 / Q000494:pharmacology
D009696:Nucleic Acids; D007288:Inosine; D009963:Orotic Acid; D010088:Oxidoreductases; D008058:Dihydrolipoamide Dehydrogenase; D003576:Electron Transport Complex IV; D004950:Esterases; D010744:Phosphoric Monoester Hydrolases; D000626:Aminopeptidases; D014805:Vitamin B 12
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