Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma.
An adult male patient with probable ectopic ACTH production by a medullary carcinoma of the thyroid, was studied before and after bilateral adrenalectomy. Pre-operatively, the patient had low plasma testosterone levels that returned to normal after surgery. The clinical course and study of the patient showed that, 1) chronic excess of ACTH may lower plasma testosterone levels in man, and 2) that this may be mediated through its effect on the adrenals.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000735:Androstenedione / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism* / Q000628:therapy; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood / Q000378:metabolism* / Q000628:therapy
D001786:Blood Glucose; D006729:Hormones, Ectopic; D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D006854:Hydrocortisone