title: Identification and measurement of urinary estrone, estradiol-17 beta, estriol, pregnanediol and androsterone during the menstrual cycle of the orangutan.
abstract: Urinary estrone, estradiol-17beta, estriol, pregnanediol and androsterone were identified and measured during 3 menstrual cycles in 2 female orangutans. In 2 of the cycles, the animals excreted 1-8 mug/day estrone, 0.5-6 mug/day estradiol-17beta, 1-8 mug/day estriol, 20-206 mug/day pregnanediol and 120-522 mug/day androsterone during the first half of the menstrual cycle. In the second half of the cycle, corresponding values were 3-21 mug/day estrone, 2-10 mug/day estradiol-17beta, 1-9 mug/day estriol, 54-800 mug/day pregnanediol and 90-1158 mug/day androsterone. In 1 cycle, the estrogen values for the second half were considerably higher, possibly due to the animal becoming pregnant just before this study commenced. The values for estrone and estradiol-17beta are similar to those found in the human and chimpanzee menstrual cycle. The values for estriol were lower than in the human but higher than in the chimpanzee. Levels for urinary pregnanediol and androsterone were significantly lower than in the human. Variations during the menstrual cycle for estrone were characterized by a midcycle peak followed by a second peak in the luteal phase. No definite pattern was apparent for estradiol-17beta or estriol. Both urinary pregnanediol and androsterone levels were low during the first half of the cycle, started to rise just after midcycle, and showed a peak during the second half of the menstrual cycle.
mesh_terms: D000738:Androsterone / Q000652:urine*; D000818:Animals; D002845:Chromatography; D002855:Chromatography, Thin Layer; D004958:Estradiol / Q000652:urine*; D004964:Estriol / Q000652:urine*; D004966:Estrogens, Conjugated (USP) / Q000652:urine; D004970:Estrone / Q000652:urine*; D005260:Female; D015186:Hominidae; D008598:Menstruation; D011276:Pregnanediol / Q000652:urine*; D013997:Time Factors; D014316:Tritium
chemical_list: D004966:Estrogens, Conjugated (USP); D014316:Tritium; D004970:Estrone; D004958:Estradiol; D000738:Androsterone; D004964:Estriol; D011276:Pregnanediol