title: Regulation of aspartokinase and homoserine dehydrogenase in acetic acid bacteria.
abstract: The regulation of aspartokinase and homoserine dehydrogenase has been studied in three Acetobacter and two Gluconobacter species. Both enzymes were regulated by feedback inhibition. Aspartokinase was inhibited by L-threonine and concertedly inhibited by L-threonine plus L-lysine. The homoserine dehydrogenase was NADP-specific and was inhibited by L-threonine. Separation of the two enzymes by ammonium sulphate fractionation was possible in Acetobacter peroxydans, A. rancens and Gluconobacter melanogenus but not in A. liquefaciens or G. oxydans.
mesh_terms: D000091:Acetobacter / Q000201:enzymology*; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D001222:Aspartate Kinase / Q000378:metabolism*; D001224:Aspartic Acid / Q000096:biosynthesis; D003960:Diaminopimelic Acid / Q000494:pharmacology; D005246:Feedback; D006714:Homoserine / Q000494:pharmacology; D006715:Homoserine Dehydrogenase / Q000378:metabolism*; D007532:Isoleucine / Q000494:pharmacology; D008239:Lysine / Q000494:pharmacology; D008715:Methionine / Q000494:pharmacology; D010770:Phosphotransferases / Q000378:metabolism*; D011548:Pseudomonadaceae / Q000201:enzymology*; D013912:Threonine / Q000494:pharmacology
chemical_list: D007532:Isoleucine; D013912:Threonine; D001224:Aspartic Acid; D003960:Diaminopimelic Acid; D006714:Homoserine; D008715:Methionine; D000429:Alcohol Oxidoreductases; D006715:Homoserine Dehydrogenase; D010770:Phosphotransferases; D001222:Aspartate Kinase; D008239:Lysine