[Development of equilibrium of glial populations in the cerebral cortex of lead intoxicated rats].
The three types of glial cells (astrocytes, oligodendrocytes and microglia) were counted at 2 different ages in normal and lead intoxicated animals (on a 0.5% Pb2+ diet) and were found to vary differently with respect to age and lead treatment. Satellisation of nerve cells by glia also displays a different pattern : whereas usually at 3 month age, the neurons are surrounded by oligodendrocytes, they appear more often encapsulated by microglia after lead treatment. It is postulated that changes in glial populations and their relationship to nerve cells could provide a sensitive indicator of lead encephalopathy.
D000375:Aging; D000818:Animals; D001253:Astrocytes / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development / Q000503:physiopathology*; D005260:Female; D007855:Lead Poisoning / Q000503:physiopathology*; D009457:Neuroglia / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology; D051381:Rats
Evolution de l'équilibre des populations gliales dans le cortex cérébral du rat intoxiqué au plomb.