The effect of natural oestrogens on coagulation.
A study was undertaken to assess the effect of natural oestrogen on the coagulation profile of menopausal women. Forty-five postmenopausal women were selected at random and treated with conjugated oestrogen (PREMARIN) FOR ONE YEAR. Blood samples were tested before treatment, at the end of 3 and 9 months' therapy, and 1 month after treatment had been suspended. Parameters studied included: fibrinogen; platelet count and aggregation; single-stage prothrombin time; kaolin partial thromboplastin time; factors v and x assays and euglobulin lysis time. The only statistically significant alteration noted was a depressant effect on the platelet count. The significance of this change is commented upon. For practical purposes, it may be concluded that treatment of a group of menopausal women with conjugated oestraogen for one year had no adverse effect on their coagulation mechanism.
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D003864:Depression, Chemical; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005165:Factor V / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000097:blood; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007616:Kaolin; D008593:Menopause; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011517:Prothrombin Time; D013997:Time Factors
D004966:Estrogens, Conjugated (USP); D007616:Kaolin; D005165:Factor V; D005170:Factor X; D005340:Fibrinogen