A syndrome of widened medullary cavities of bone, aortic calcification, abnormal dentition, and muscular weakness (the Singleton-Merten syndrome).
Two patients with clinical and radiological features similar to those of Singleton and Merten's patients are described. These patients exhibit features of a unique clinical syndrome of unknown etiology: generalized muscular weakness with secondary hip and foot deformities, progressive calcification of the thoracic aorta beginning in childhood, calcific aortic stenosis leading to heart failure, dysplasia of the teeth, poor physical development, osteoporosis, expanded medullary cavities of the metacarpal and metatarsal bones, and chronic psoriaform skin lesions.
D000293:Adolescent; D001018:Aortic Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D001847:Bone Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D003744:Dental Enamel Hypoplasia / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000150:complications*; D018126:Odontodysplasia / Q000150:complications / Q000000981:diagnostic imaging*; D010024:Osteoporosis / Q000150:complications / Q000000981:diagnostic imaging; D011565:Psoriasis / Q000150:complications; D011859:Radiography; D013577:Syndrome