Possible role of the serotonergic system in the behavioral effect of massed electroconvulsive shock in rat.
Massed electroconvulsive shock (ECS) inhibited escape in a one-way avoidance system and tolerance to this effect developed in rats shocked for 4 consecutive days (1, 4, 5 and 10 ECS respectively). Chronic treatment with p-bromo-N-methylamphetamine (V-III) as well as pretreatment with pCPA antagonized the behavioral disturbing effect of massed ECS strongly supporting the idea that 5-HT plays an important role in observed behavioral effects.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004597:Electroshock; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*
D012701:Serotonin; D008694:Methamphetamine; D006916:5-Hydroxytryptophan; D010134:Fenclonine