An evaluation of adenosine 3',5'-cyclic monophospate-dependent protein kinase activity in atopic dermatitis.
Activity of adenosine 3',5'-cyclic monophosphate-dependent protein kinase has been measured in the skin of normal controls, patients with non-atopic skin disorders, and those with atopic dermatitis. All samples analyzed displayed the presence of this enzymatic activity. However, the enzyme from the atopic skin did not seem to be dependent on cyclic AMP for activity. Whether this is due to an artifact of isolation of protein kinase or is indeed the true in vivo nature of the enzyme remains to be established.
D000242:Cyclic AMP; D003876:Dermatitis, Atopic / Q000201:enzymology*; D004790:Enzyme Induction; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D012867:Skin / Q000201:enzymology*
D000242:Cyclic AMP; D011494:Protein Kinases