title: Malignant transformation of hamster brain cells in vitro by human papovavirus Bk.
abstract: Human papovavirus BK caused the malignant transformation in vitro of brain cells prepared from newborn hamsters. The transformed cells produced BK virus T antigen and grew as tumors after sc inoculation ito hamsters that developed antibodies to BK virus T antigen. The histopathology of the tumors revealed an undifferentiated glioma.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D005910:Glioma / Q000209:etiology / Q000276:immunology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology; D011120:Polyomavirus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral