[Enzyme alterations of the arterial wall following the combination of a lathyrogenic treatment and of moderate hypercholesterolemia in the young rabbit].
To determinate the part of humoural and parietal factors in atherosclerotic injury genesis, metabolism alteration study is realised on aortic cell wall of rabbits which are submitted to a chronical lathyritic intoxication alone, or simultaneously or alternatively associated with a cholesterolemic diet. Catabolic activity increase of beta-glucuronidase occurs in hypercholesterolemic rabbits. Beta-aminoproprionitrile, lathyrogenic drug used, stimulates biosynthetic pathways: increase of soluble proteins, energetic enzyme activities (lacticodeshydrogenase, malicodeshydrogenase), conjonctival protein metabolism (procollagen lysyl hydroxylase); in the same time, cell wall disturbances and lipidic deposits are facilitate when rabbits are submitted to cholesterolemic diet.
D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D001161:Arteriosclerosis / Q000201:enzymology*; D002784:Cholesterol / Q000097:blood / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis; D003402:Creatine Kinase / Q000032:analysis; D004036:Diet, Atherogenic; D005966:Glucuronidase / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008291:Malate Dehydrogenase / Q000032:analysis; D011393:Procollagen-Proline Dioxygenase / Q000032:analysis; D011506:Proteins / Q000032:analysis; D011817:Rabbits
D011506:Proteins; D000629:Aminopropionitrile; D003094:Collagen; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D011393:Procollagen-Proline Dioxygenase; D003402:Creatine Kinase; D005966:Glucuronidase
Altérations enzymatiques de la paroi artérielle consécutives à l'association d'un traitement lathyrogène et d'une hypercholestérolémie modérée chez le lapin