title: Anti-inflammatory models in animals.
abstract: The pleural cavity of rats and guinea-pigs has been utilized to study the inflammatory response to immediate hypersensitivity, delayed hypersensitivity, calcium pyrophosphate and carrageenan. The mediators will be described and their possible interaction with cyclic AMP. Finally the effect of some anti-inflammatory agents on these models will be discussed.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology; D001183:Arthus Reaction; D002351:Carrageenan / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D011756:Diphosphates / Q000494:pharmacology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007249:Inflammation; D008168:Lung / Q000276:immunology; D010994:Pleura / Q000276:immunology; D051381:Rats; D013582:Synovial Fluid / Q000032:analysis
chemical_list: D011756:Diphosphates; D002351:Carrageenan; D000242:Cyclic AMP