A comparison of the relative rates of hemolysis induced by various fibrogenic and non-fibrogenic particles with washed rat erythrocytes in vitro.
Correlations between in vitro hemolytic activity and the in vivo fibrogenic activity of a number of particulate materials are demonstrated. Fibrogenic particles are capable of inducing hemolysis, while non-fibrogenic particles are not. It is suggested that particulates inducing a rate of hemolysis greater than 1 X 10(-4) min-1 may be fibrogenic.
D000818:Animals; D001194:Asbestos / Q000633:toxicity; D001713:Biphenyl Compounds / Q000633:toxicity; D002118:Calcium / Q000633:toxicity; D002516:Ceramics; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006842:Hydrocarbons, Brominated / Q000633:toxicity; D007616:Kaolin / Q000633:toxicity; D008274:Magnesium / Q000633:toxicity; D010316:Particle Size; D010710:Phosphates / Q000633:toxicity; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D051381:Rats; D012824:Silicic Acid / Q000633:toxicity; D012822:Silicon Dioxide / Q000633:toxicity; D013627:Talc / Q000633:toxicity; D014025:Titanium / Q000633:toxicity
D001713:Biphenyl Compounds; D006842:Hydrocarbons, Brominated; D010710:Phosphates; D001194:Asbestos; D012824:Silicic Acid; D013627:Talc; D007616:Kaolin; D012822:Silicon Dioxide; D014025:Titanium; D008274:Magnesium; D002118:Calcium