title: Contribution of long chain fatty acids to the energy supply of the rat kidney cortex.
abstract: Tubular fragments from rat kidney cortex were isolated by collagenase and suspended in an incubation medium containing a combination of several renal substrates. Substrate concentrations were in the physiological range. O2 uptake, total CO2 production, and the 14CO2 production from U-14C-labeled palmitate and oleate were measured. During the first minutes of incubation the CO2 production from palmitate and oleate was 10.5% or 6.3%, respectively, of the total CO3 produced. The RQ was 0.897. A subsequent decrease of the total CO2 production at a constant uptake of oxygen indicated a rising contribution of fatty acids to the fuel of respiration. The renal preference for substrates other than longchain fatty acids is discussed.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004734:Energy Metabolism; D066298:In Vitro Techniques; D007684:Kidney Tubules / Q000378:metabolism* / Q000648:ultrastructure; D003012:Microbial Collagenase; D009829:Oleic Acids / Q000378:metabolism; D010101:Oxygen Consumption; D010168:Palmitates / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats
chemical_list: D009829:Oleic Acids; D010168:Palmitates; D010169:Palmitic Acids; D002245:Carbon Dioxide; D003012:Microbial Collagenase