title: [Beta-sitosterin in unsuccessfully pretreated patients with hypercholesteremia. Simultaneously, a contribution to dose dependence].
abstract: To 9 patients with hyperlipoproteinemia type II and treated with different hypolipidemic drugs without success, sitosterol was given for a period of 4 to 16 months. The effective dose was 10.56 to 21.12g beta-sitosterol corresponding to 12 to 24g granulate. One patient developed a serious diarrhoe and dropped out. 4 patients showed an impressive decrease of serum cholesterol levels.
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012855:Sitosterols / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D012855:Sitosterols; D014280:Triglycerides; D002784:Cholesterol
vernacular_title: Beta-Sitosterin bei erfolglos vorbehandelten Patienten mit Hypercholesterinämie. Gleichzeitig ein Beitrag zur Dosisabhängigkeit