Glomerular immune complex deposits associated with mouse mammary tumor.
Adult Paris R-III mice with localized mamary tumors were found to have subendothelial glomerular immune complex deposits by electron microscopy and immunofluorescence. In addition to IgG adn B-1-C, the glomeruli contained antigenic material that reacted with an antiserum to mouse mamary tumor virus. These findings support the hypothesis that many animals with congenitally or neonatally induced virus-related tumors are not immunologically tolerant to the oncogenic virus.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006041:Goats / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008854:Microscopy, Electron; D011817:Rabbits / Q000276:immunology
D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D007074:Immunoglobulin G