title: [Hydrolysis of the methyl esters of the N-arylsulfonyl derivatives of L-arginine by thrombin and trypsin].
abstract: Trypsin- and thrombin-catalysed hydrolysis of the Nalpha-aryl-sulfonyl-L-arginine methyl esters was studied. Michaelis constants and kcat were determined. The hydrolysis of the substrates by trypsin appears to depend on the polar nature of substitutes. The thrombin- catalysed reaction was believed to be sensitive to steric effects of the introducted groups.
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D001190:Arylsulfonates / Q000378:metabolism*; D006868:Hydrolysis; D007700:Kinetics; D008738:Methyl Ethers / Q000378:metabolism; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000378:metabolism*; D014357:Trypsin / Q000378:metabolism*
chemical_list: D001190:Arylsulfonates; D008738:Methyl Ethers; D001120:Arginine; D014357:Trypsin; D013917:Thrombin
vernacular_title: Gidroliz metilovykh éfirov N-arilsul'fonilproizvodnykh L-arginina trombinom i tripsinom