Influence of anti-oestrogens on the specific binding in vitro of (3H)oestradiol by cytosol of rat mammary tumours and human breast carcinomata.
The anti-oestrogenic potential of two nitrogen-mustard-containing compounds, I.C.I. 79792 and I.C.I. 85966, was studied. I.C.I. 85966 usually did not decrease specific binding of [3H]oestradiol by breast-tumour cytoplasmic proteins. I.C.I. 79792 decreased specific [3H]oestradiol binding, but not to the same extent as similar concentrations of I.C.I. 46474, diethylstilboestrol or dibutyldihydrostilboestrol.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004054:Diethylstilbestrol / Q000031:analogs & derivatives / Q000494:pharmacology; D004958:Estradiol / Q000378:metabolism*; D004965:Estrogen Antagonists; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology; D014316:Tritium
D004965:Estrogen Antagonists; D009588:Nitrogen Mustard Compounds; D011956:Receptors, Cell Surface; D013629:Tamoxifen; D014316:Tritium; D004958:Estradiol; D004054:Diethylstilbestrol