[Postnatal development of the rat retina under DNS-inhibitor (chloroquinediphosphate) mediation (author's transl)].
The morphogenesis of retina has been studied in 1-15 day-old rats after a single injection of chloroquinediphosphate. Beside degeneration of neuroblasts, rate of development was markedly retarded as evidence by regression of the strata reticulares. Neuroblasts or receptor cells remained disorganized and were arranged in rosettes. In the inner layer containing the third neuron myelinated bodies were produced by the drug.
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000187:drug effects; D002467:Cell Nucleus / Q000648:ultrastructure; D002738:Chloroquine / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects; D002479:Inclusion Bodies / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D010786:Photoreceptor Cells / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D012160:Retina / Q000254:growth & development* / Q000473:pathology; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D002738:Chloroquine
Die postnatale Entwicklung der Rattenretina unter Einfluss eines DNS-Hemmers (Chloroquinidiphosphat)