Antibody responses to a combination vaccine against Haemophilus influenzae type b, diphtheria, pertussis, and tetanus.
Forty-one children were studied in order to provide information on antibody responses to H. influenzae type b polyribophosphate (PRP), given in combination with diphtheria-pertussis-tetanus vaccine (DPT). When PRP was administered alone, 9 of 15 children demonstrated fourfold or greater increases in titres of anti-PRP antibody. In contrast, in the group receiving a combination vaccine consisting of DPT and PRP only 1 of 13 children showed a similar rise in anti-PRP antibody. It was concluded that, in the population studied, the combination vaccine was less effective than PRP alone. The reasons for this difference and its potential significance are discussed.
D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001886:Bordetella pertussis / Q000276:immunology; D002675:Child, Preschool; D004167:Diphtheria Toxin / Q000008:administration & dosage; D005260:Female; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage; D013745:Tetanus Toxoid / Q000008:administration & dosage
D001428:Bacterial Vaccines; D004167:Diphtheria Toxin; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid