[Mechanisms of carcinogenesis associated with DNA repair].
The paper presents data from the literature and the author's own materials on the correlation between the extent of activity of reparation processes and the development of cell malignization. A review cites the results of investigations on the molecular mechanisms in some hereditary human diseases in which a defect in some stages of the reparation processes has been found (xeroderma, ataxia telangesthesia. Fanconi anemia, Down's syndrome, etc.). These diseases are also characterized by a high rate of neoplasia development. It is emphasized that inhibition of the reparation process is observed only in the first stages of normal cell transformation into a malignant one. A correlation between carcinogenic and mutagenic activity of chemical compounds which is in favour of the mutation hypothesis of the origin of tumours is discussed.
D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics / Q000473:pathology; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000473:pathology; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D004314:Down Syndrome / Q000235:genetics / Q000473:pathology; D005199:Fanconi Anemia / Q000235:genetics / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000473:pathology
D002273:Carcinogens
Mekhanizmy kantserogeneza, sviazannye s reparatsieĭ DNA.