[Immunologic results obtained with an experimental system oftransplantable colonic tumors. Possible applications of these results to human intestinal tumors].
Intestinal cancers, morphologically very close to human colo-rectal adeno-carcinoma, have been induced by dimethylhydrazine in inbred rats. Graftable lines have been obtained from 5 primary intestinal tumors, and 3 cell lines have been cultivated from the grafts. This model was used to demonstrate carcinofetal antigen(s) on the surface of the intestinal cancer cells. Circulating antibodies against tumor-associated antigen(s) have been found in tumor-bearing rats. Cancer enhancement was regularly observed when specific (tumor cells) and non-specific (B.C.G.) immunologic treatments were used to prevent or cure rat intestinal tumors. These results suggest that immunotherapy of human colo-rectal cancer might be hazardous.
D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced / Q000276:immunology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002460:Cell Line; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000276:immunology*; D004127:Dimethylhydrazines; D007167:Immunotherapy; D009374:Neoplasms, Experimental; D051381:Rats
D000951:Antigens, Neoplasm; D004127:Dimethylhydrazines
Résultats immunologiques obtenus avec un systéme expérimental de tumeurs coliques greffables. Applications possibles de ces résultats aux tumeurs intestinales humaines