title: Etiology of hyperuricemia.
abstract: Hyperuricemia is a common laboratory finding with significant clinical implications. It is easily detected, but its mechanisms may not be clearly elucidated. A scheme of pathogenesis has been outlined and diagrammed but much is conjectural; therefore, the classification is merely tentative. About 45 diseases or categories of conditions, 20 drugs, and nine states of intoxication have been surveyed. Hyperuricemia can be a multifactorial genetic disorder or a discrete response to a specific stimulus. It may be governed by a complex interplay of biochemical disorders for a lifetime duration, or it may be determined by environmental forces for a very transient course. Some conditions have both increased production of uric acid as well as decreased renal outflow. For many patients, the underlying mechanisms have not yet been elucidated.
mesh_terms: D000740:Anemia / Q000150:complications; D004032:Diet; D004232:Diuretics / Q000009:adverse effects; D004700:Endocrine System Diseases / Q000150:complications; D005260:Female; D005633:Fructose Intolerance / Q000150:complications; D006073:Gout / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000150:complications; D007926:Lesch-Nyhan Syndrome / Q000097:blood; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology; D008661:Metabolism, Inborn Errors / Q000150:complications; D008733:Methoxyflurane / Q000009:adverse effects; D009196:Myeloproliferative Disorders / Q000150:complications; D009369:Neoplasms / Q000150:complications; D009711:Nucleotides / Q000378:metabolism; D010430:Pentosyltransferases / Q000172:deficiency; D005082:Physical Exertion; D011041:Poisoning / Q000097:blood; D011247:Pregnancy; D011687:Purines / Q000096:biosynthesis; D012268:Ribose-Phosphate Pyrophosphokinase / Q000378:metabolism; D014527:Uric Acid / Q000097:blood*
chemical_list: D004232:Diuretics; D009711:Nucleotides; D011687:Purines; D014527:Uric Acid; D008733:Methoxyflurane; D010430:Pentosyltransferases; D007041:Hypoxanthine Phosphoribosyltransferase; D012268:Ribose-Phosphate Pyrophosphokinase