Cimetidine fails to block functional antagonism of carbachol by histamine in rat trachea.
Histamine and dimaprit functionally antagonised the ability of carbachol to constrict the rat trachea in the presence of mepyramine. Cimetidine did not block the functional antagonism of histamine or dimaprit for carbachol.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors*; D002927:Cimetidine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects*
D006146:Guanidines; D006633:Histamine Antagonists; D002927:Cimetidine; D002217:Carbachol; D013890:Thiourea