Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice.
DNA synthesis in a transplanted hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was significantly reduced (P less than 0.01) in rats maintained on diets low (0.4 mug/g) or high (greater than or equal to 500 mug/g) in zinc when compared with control animals given 60 mug zinc/g. 3-Methylcholanthrene-induced carcinogenesis was considerably lowered in mice receiving the same low or high zinc diets during the induction periods.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D008113:Liver Neoplasms / Q000378:metabolism*; D008748:Methylcholanthrene / Q000037:antagonists & inhibitors*; D051379:Mice; D009374:Neoplasms, Experimental; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*
D004273:DNA, Neoplasm; D008748:Methylcholanthrene; D015032:Zinc; D013936:Thymidine