title: DNA-negative temperature-sensitive mutants of herpes simplex virus type 1: patterns of viral DNA synthesis after temperature shift-up.
abstract: Temperature-sensitive mutants of herpes simplex virus type 1 belonging to four DNA- complementation groups exhibited two distinct patterns of viral DNA synthesis after shift-up to the nonpermissive temperature. In cultures infected with mutants belonging to complementation groups A, C, and D, little or no viral DNA was synthesized after shift-up. In cultures infected with a mutant in complementation group B, nearly normal amounts of viral DNA were synthesized after shift-up.
mesh_terms: D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D005816:Genetic Complementation Test; D009154:Mutation; D018139:Simplexvirus / Q000378:metabolism*; D013696:Temperature
chemical_list: D004247:DNA