Antagonism of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary in vitro by somatostatin analogues.
The PGE2-induced cyclic AMP accumulation in the rat anterior pituitary in vitro is inhibited by [desamino1]-[desamino1] [descarboxy14]- and [D-Lys4]-somatostatin similarly to somatostatin, while the [descarboxy14]-somatostatin exhibits reduced activity; [D-Lys9]-somatostatin is ineffective at a higher concentration.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011458:Prostaglandins E; D013004:Somatostatin; D000242:Cyclic AMP