[Phospholipid composition of synaptosomes from the brains of normal rabbits and rabbits poisoned with phospho-organic cholinesterase inhibitors].
The authors studied quantitative and qualitative composition of phospholipids isolated by fractionation in the sucrose density gradient. The diacyl-aminophospholipid (APL) content of synaptosomes was lower than that of the brain homogenates. On the other hand, the plasmologen APL, phosphoinositide and phosphatidylcholine content was greater in the synaptosomes. Strong excitation of the CNS induced with organo phosphorus inhibitors resulted in a 25% decrease of diacyl APL contnet and a 17% elevation of plasmalogen APL content in the whole brain homogenate. The phospholipid composition of synaptosomes remained unchanged, however.
D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D001923:Brain Chemistry; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D008297:Male; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D010713:Phosphatidylcholines / Q000032:analysis; D010716:Phosphatidylinositols / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D011041:Poisoning / Q000378:metabolism; D011817:Rabbits; D013574:Synaptosomes / Q000032:analysis*
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D010743:Phospholipids
Fosfolipidnyĭ sostav sinaptosom iz mozga krolikov v norme i pri intoksikatsii fosfororganicheskimi ingibitorami kholinésterazy