Light and electron microscopic study of dysplastic rosette-like structures occurring in the disorganized mature retina.
Histopathologic examination of six, adult human eyes revealed "rosette-like" structures in the retina which appear to have developed after maturation of the retina. These structures resemble dysplastic rosettes which are generally interpreted as a sign of maldevelopment of the retina (retinal dysplasia). The underlying lesions in the eyes of these patients were ocular ischemia, sickle-cell retinopathy, diabetic retinopathy, central retinal vein occlusion, and trauma. It is suggested that a distinction should be made between these degenerative-regressive changes and dysplastic rosettes which represent an abortive attempt of regeneration by germinal cells.
D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000473:pathology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D010786:Photoreceptor Cells / Q000648:ultrastructure; D012038:Regeneration; D012160:Retina / Q000002:abnormalities* / Q000648:ultrastructure; D012162:Retinal Degeneration / Q000473:pathology; D012163:Retinal Detachment / Q000473:pathology