title: The effects of cholera toxin on the adrenal weight in hypophysectomized rats.
abstract: The effects of cholera on adrenal weight in hypophysectomized rats were investigated, in an attempt to demonstrate an ACTH-like, adrenal trophic effect of the toxin. The results suggested that the toxin probably exerts is ACTH-like action on the adrenal via adenylate cyclase. Cholera toxin was also shown to have a thermolytic action, similar to that of ACTH, probably due to stimulation of adrenal glucocorticoid secretion.
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology* / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001835:Body Weight; D004731:Endotoxins / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D009929:Organ Size; D009928:Organ Specificity; D051381:Rats; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013950:Thymus Gland / Q000033:anatomy & histology / Q000187:drug effects; D014734:Vibrio cholerae
chemical_list: D004731:Endotoxins; D000324:Adrenocorticotropic Hormone