title: [Effect of autonomotropic agents and their combinations with amidopyrine on aesptic inflammation and vascular permeability].
abstract: Experiments staged on rats demonstrated the display of antiexudative activity by phepracet, deseryl, chlorpromazine, phentolamine and sanotension in an inflammation produced through subplantar introduction of the Difco agar. Some of the above agents suppressed the reaction in response to dimethyl sulfoxide injection. The antiedematous and stabilizing the cellular membranes effects of amidopyrine were potentiated by using the latter in combination with sympatholytics and also with benactyzine. No synergism with respect to changes of the vascular permeability and kinnase activity of the blood was revealed.
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000632:Aminopyrine / Q000494:pharmacology*; D000662:Amphetamines; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D001535:Benactyzine / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D004338:Drug Combinations; D005070:Evans Blue; D005122:Exudates and Transudates / Q000187:drug effects; D006145:Guanethidine / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008784:Methysergide / Q000494:pharmacology; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D010646:Phentolamine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012867:Skin / Q000187:drug effects; D013997:Time Factors; D014326:Tropanes / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000662:Amphetamines; D000814:Aniline Compounds; D001337:Autonomic Agents; D004338:Drug Combinations; D014326:Tropanes; D000632:Aminopyrine; C009756:fepracet; D005070:Evans Blue; D001535:Benactyzine; D012110:Reserpine; D007703:Peptidyl-Dipeptidase A; D002746:Chlorpromazine; D008784:Methysergide; D010646:Phentolamine; D006145:Guanethidine
vernacular_title: O vliianii vegetotropnykh sredstv i ikh kombinatsiĭ s amidopirinoma na asepticheskoe vospalenie i sosudistuiu pronitsaemost'