Nonrandom distribution of receptors for melanocyte-stimulating hormone on the surface of mouse melanoma cells.
An improved bubble method was developed for applying an ultrathin layer of nuclear track emulsion on the surface of cells labeled with I125-MSH. The autoradiographs of I125-MSH binding indicate a nonrandom distribution of receptors on the surface of mouse melanoma cells. It is suggested that MSH receptors are displayed in clusters previous to and independently of their exposure to the hormone.
D000096:Acetone; D001345:Autoradiography / Q000379:methods*; D002460:Cell Line; D002462:Cell Membrane / Q000648:ultrastructure*; D005976:Glutaral; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D011956:Receptors, Cell Surface; D013696:Temperature
D011956:Receptors, Cell Surface; D000096:Acetone; D009074:Melanocyte-Stimulating Hormones; D005976:Glutaral