title: Comparative effect of insulin and explanted adrenal medullary tissue and rat adrenal medulla in situ.
abstract: The adrenal medulla and explanted medullary cells in the anterior chamber of the eye were examined 3 h after the administration of insulin to rats. No alterations were seen in the explanted cells. In the adrenal medulla, light and electron microscopy indicated depletion of adrenaline cells; noradrenaline cells were not affected. Levels of catecholamines were three times higher in the explanted tissue after insulin treatment; in the medulla in situ they declined by 70%. These results confirm that insulin has no direct releasing effect on chromaffin cells.
mesh_terms: D000313:Adrenal Medulla / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000637:transplantation; D000818:Animals; D000867:Anterior Chamber / Q000601:surgery; D002395:Catecholamines / Q000378:metabolism; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000187:drug effects; D004837:Epinephrine / Q000378:metabolism; D005215:Fasting; D005260:Female; D006056:Golgi Apparatus / Q000187:drug effects; D002479:Inclusion Bodies / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
chemical_list: D002395:Catecholamines; D007328:Insulin; D009638:Norepinephrine; D004837:Epinephrine