Effects of hexachlorobutadiene (HCBD) on renal function and renal organic ion transport in the rat.
1,3-Hexachorobutadiene (HCBD) has been suggested to cause nephrotoxicity. In addition, it is eliminated to a large extent in the urine. This study was designed to examine the effects of HCBD on overall renal function and specific renal transport systems in the rat. A single i.p. dose of 100 mg HCBD/kg caused a reduction in urine osmolality and body weight. Urine flow rate increased slightly and marked increases in urinary protein, glucose and ketones were observed. Renal slices after the same dose showed a reduced PAH accumulation. The transport of other organic compounds was affected only slightly. After daily administration on 4 successive days with various doses a graded response was observed on both transport and overall renal function. Glutathione administered in a 2.5-fold molar excess did not obtund the effects of HCBD on renal function or transport
D000818:Animals; D002070:Butadienes / Q000633:toxicity*; D004573:Electrolytes / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D009536:Niacinamide / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D010130:p-Aminohippuric Acid / Q000378:metabolism
D002070:Butadienes; D004573:Electrolytes; D009536:Niacinamide; C001335:hexachlorobutadiene; D005978:Glutathione; D010130:p-Aminohippuric Acid