Iterferon induction in mice by BHK cells persistently infected with HVJ.
Intraperitoneal injection into mice of BHK-HVJ cells (BHK cells persistently infected with HVJ) induced considerable amounts of circulating interferon. Sonication of BHK-HVJ cells almost totally abolished their interferon inducing capacities. This result suggests that a certain native organized structure of virus infected cells might be essential for production of interferon in this system, as is suggested in the in vitro sytem.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000637:transplantation*; D006224:Cricetinae; D007274:Injections, Intraperitoneal; D007372:Interferons / Q000097:blood*; D007668:Kidney; D051379:Mice; D008810:Mice, Inbred C57BL; D010222:Parainfluenza Virus 1, Human / Q000254:growth & development*; D013010:Sonication; D014183:Transplantation, Heterologous
D007372:Interferons