Pathogenesis of Machupo virus infection in primates.
Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys.
D000818:Animals; D006477:Arenaviruses, New World / Q000276:immunology; D003165:Complement System Proteins; D004195:Disease Models, Animal; D000882:Haplorhini; D006478:Hemorrhagic Fever, American / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D006482:Hemorrhagic Fevers, Viral / Q000276:immunology*; D007165:Immunosuppression Therapy; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000276:immunology*
D003165:Complement System Proteins