A potent depressant action of adenine derivatives on cerebral cortical neurones.
Adenosine and several adenine nucleotides depress the excitability of cerebral cortical neurones, including identified Betz cells. Cyclic 3',5'-adenosine monophosphate was a less effective depressant than various other adenine nucleotides, including cyclic 2',3'-adenosine monophosphate. Adenine and inosine had only weak depressant activity. An initial excitant action of ATP was observed on several neurones. This was succeeded by a depressant effect when the application of ATP was terminated.
D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000227:Adenine Nucleotides / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D000242:Cyclic AMP / Q000096:biosynthesis / Q000494:pharmacology; D003864:Depression, Chemical; D005971:Glutamates / Q000494:pharmacology; D066298:In Vitro Techniques; D007288:Inosine / Q000494:pharmacology; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats
D000227:Adenine Nucleotides; D005971:Glutamates; D007288:Inosine; D000242:Cyclic AMP; D000225:Adenine; D000241:Adenosine