[Cytological characteristics of a bovine kidney cell culture chronically infected with foot-and-mouth disease virus (author's transl)].
A virus-carrier state was observed in the process of subcultivation of foot-and-mouth disease virus-infected calf kidney cell culture. Cytologically, the chronically infected culture differed from the control culture by the presence of a large number of syncytial cells which did not die in acute infection because of poor susceptibility to the virus. Chronic infection appeared to be maintained by occasionaly polygonal cells which retained the initial sesceptiblity to foot-and-mouth disease virus. The number of such cells did not exceed 1--4% and by the 9th passage they disappeared completely. At this time the experimental culture did not differ from control cytologically and cytochemically.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D005537:Aphthovirus / Q000276:immunology / Q000472:pathogenicity*; D002417:Cattle; D002467:Cell Nucleus; D002478:Cells, Cultured / Q000166:cytology*; D003470:Culture Media; D003584:Cytological Techniques; D003588:Cytopathogenic Effect, Viral; D005455:Fluorescent Antibody Technique; D007620:Karyometry; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D013997:Time Factors; D014779:Virus Replication
D000956:Antigens, Viral; D003470:Culture Media
Tsitologicheskaia kharakteristika kletochnoĭ kul'tury bych'eĭ pochki, khronicheski infitsirovannoĭ virusom iashchura