Effect of levodopa on urinary bladder.
Levodopa therapy enhanced the ability of the bladder to store urine in two parkinsonian patients. In vitro canine muscle bath studies with the two major metabolites of levodopa, dopamine and norepinephrine, indicate that the effects of the drug on the peripheral sympathetic nervous system may play a major role in the improvement of urinary symptoms observed with levodopa therapy.
D000368:Aged; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D005725:Ganglia, Autonomic / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009132:Muscles / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010300:Parkinson Disease / Q000188:drug therapy; D009435:Synaptic Transmission / Q000187:drug effects; D014521:Urethra / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology
D007980:Levodopa; D004298:Dopamine; D009638:Norepinephrine