Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye.
Our previous studies showed that cyclic-AMP increases the outflow facility of the eye of the rabbit. In this investigation, an analogue of cyclic-AMP, the 8-methylthio derivative, perfused into the anterior chamber of the eye of the vervet monkey, increased outflow facility twofold. This observation supports the hypothesis that cyclic-AMP mediates the action of adrenergic agents to reduce intraocular pressure in the primate eye.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002521:Cercopithecus; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D000882:Haplorhini; D012636:Secretory Rate / Q000187:drug effects
D000242:Cyclic AMP