[Effect of protein deprivation on ammonia metabolism in the rat].
In order to investigate the mechanisms of the hyperammonemia previously described in protein deprivation, the effects of sucrose and fasting on the ammonia metabolism were studied in control, streptozotocine-induced diabetics and colectomized rats. Hyperammonemia, hyperglutaminemia, hypouremia and intolerance to an ammonium load were observed in the control group after a 5 days sucrose-feeding. Any of these abnormalities were found in the diabetic animals whereas hyperglutaminemia did not occur in colectomized animals. It is concluded that protein deprivation obtained by sucrose feeding involves an hyperammonemia by a reduction of ureogenesis (which seemed to be related to an elevation of the ratio insulin/glucagon) and an hyperglutamininemia of colic origin.
D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003082:Colectomy; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005973:Glutamine / Q000097:blood; D008297:Male; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005973:Glutamine; D000641:Ammonia; D014508:Urea
Effet de la carence protéique sur le métabolisme ammoniacal chez le rat.