[Demonstration of the myotoxic effect of theophylline on the isolated kidney glomerulus of the rat].
After confirmation of the intense and very fast myorelaxant effect of theophylline on isolated glomeruli, xanthic reagent myotoxic effects are shown during more or less long contacts with these glomerular suspensions. We studied isolated glomeruli diameter evolution according to reagent dose (0,25 to 10 mg/ml) and its contact length (1, 5, 10 minutes). If the diameter remains practically constant during all the period for the lowest doses, it begins to decrease after the 5th minute for higher (1 and 2,5 mg/ml) and cracks up in the first minutes for the biggest ones (5 and 10 mg/ml). Pharmacologic and toxic actions are discussed ; hypothesis of a toxic effect at smooth muscular cells level is proposed.
D000818:Animals; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D013806:Theophylline / Q000633:toxicity*; D013997:Time Factors
D013806:Theophylline
Mise en évidence de l'action myotoxique de la théophylline sur les glomérules isolés de rein de rat.