The effect of heparin on serum lipoprotein-X.
Serum lipoprotein-X was investigated in 12 patients with cholestasis in basal conditions and 20 minutes after intravenous heparin. In all cases, lipoprotein-X was positive in the first sample and became negative after heparin. A decrease in triglycerides was observed in all patients after heparin with an increase in free fatty acids and mobilization of prebetalipoproteins, and a transformation of lecithin into lysoleithin in 4 cases after heparin. These facts suggest that heparin plays an important role in the mobilization of serum lipoprotein-X.
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008244:Lysophosphatidylcholines / Q000097:blood; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D014280:Triglycerides; D006493:Heparin