Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas.
Tumor-specific antigens of cells of the diethylnitrosamine-induced hepatomas in strain-2 guinea pigs were extracted with 3 M KCl. Immunization of normal animals with the extracted tumor antigens in adjuvant protected them against a subsequent challenge with viable tumor cells. Extracted tumor-specific antigens were less effective immunogens than viable tumor cells for both of two antigenically distinct lines.
D000818:Animals; D000951:Antigens, Neoplasm; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control; D004052:Diethylnitrosamine; D006168:Guinea Pigs; D007114:Immunization; D008113:Liver Neoplasms / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D011189:Potassium Chloride
D000951:Antigens, Neoplasm; D004052:Diethylnitrosamine; D011189:Potassium Chloride