[Methods of the multivariate statistical analysis of so-called polyetiological diseases using the example of coronary heart disease].
General characteristics of the multivariate statistical analysis (MSA) is given. Methodical premises and criteria for the selection of an adequate MSA method applicable to pathoanatomic investigations of the epidemiology of multicausal diseases are presented. The experience of using MSA with computors and standard computing programs in studies of coronary arteries aterosclerosis on the materials of 2060 autopsies is described. The combined use of 4 MSA methods: sequential, correlational, regressional, and discriminant permitted to quantitate the contribution of each of the 8 examined risk factors in the development of aterosclerosis. The most important factors were found to be the age, arterial hypertension, and heredity. Occupational hypodynamia and increased fatness were more important in men, whereas diabetes melitus--in women. The registration of this combination of risk factors by MSA methods provides for more reliable prognosis of the likelihood of coronary heart disease with a fatal outcome than prognosis of the degree of coronary aterosclerosis.
D000328:Adult; D000368:Aged; D001344:Autopsy; D003201:Computers; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D012044:Regression Analysis; D012306:Risk; D012426:Russia; D013223:Statistics as Topic
Metody mnogomernogo statisticheskogo analiza tak nazyvaemykh poliétiologicheskikh zabolevaniĭ na primere koronarnoĭ bolezni serdtsa.