title: [Change of toxicity and carcinogenicity of n-methyl-n-nitrosobenzylamine in rats by methylsubstitution at the c-atoms adjacent to nitrogen (author's transl)].
abstract: Substitution with a methyl group at the C-atoms adjacent to nitrogen of N-nitroso-N-methylbenzylamine (NMBA) results in a considerable reduction LD 50: N-nitroso-N-methylbenzylamine : 18 mg/kg (Druckrey et al., 1967) N-nitroso-N-methyl-(1-phenyl)-ethylamine (I) : 600 mg/kg N-nitroso-N-methyl-2-(2-phenyl)-propylamine (II) : 2100 mg/kg N-nitroso-N-ethyl-benzylamine (III) : 250 mg/kg Substitution with a methyl group at the methylene of the moiety of NMBA (NMPEA I) reduces also the carcinogenic activity, but it produces in all animals carcinomas of the oesophagus and the pharynx; the replacement of both H-atoms by methyl groups (NMPPA, II) causes under the condition chosen no development of tumors, because for the activation step no proton is available. The exchange of N-methyl by N-ethyl of NMBA (NEBA, III) however produces no change in the carcinogenicity.
mesh_terms: D000818:Animals; D002244:Carbon; D002273:Carcinogens; D002625:Chemistry, Organic; D005260:Female; D008745:Methylation; D009584:Nitrogen; D009602:Nitrosamines / Q000633:toxicity*; D055601:Organic Chemistry Phenomena; D051381:Rats
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; D002244:Carbon; D009584:Nitrogen
vernacular_title: Veränderung der Toxicität und Carcinogenität von N-Nitroso-N-methyl-benzylamin durch Methylsubstitution an den Stickstoff benachbarten C-Atomen bei Ratten.