Muscle spindles in rheumatoid arthritis. An ultrastructural study.
Ultrastructural features of muscle spindles were studied in biopsy material from 100 patients suffering from classical rheumatoid arthritis. Thickening of the outer capsule, increased amount of extracellular ground substance within the inner capsule, and marked thickening of the basement membrane of capillary blood vessels supplying the muscle spindles were observed. Chronic inflammatory cells and macrophages were present within the spindles. Changes affecting the intrafusal muscle fibres were also seen. They were manifest as atrophy and degeneration of the intrafusal muscle fibres, absence of the specialised junctional complexes, and of the intercellular bridges, microladders and satellite cells. It is suggested that the changes affecting the intrafusal muscle fibres are probably secondary. Damage to the myelinated nerves was present, while the sensory and motor nerve endings were well preserved.
D001172:Arthritis, Rheumatoid / Q000473:pathology*; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D002196:Capillaries / Q000648:ultrastructure; D005110:Extracellular Space / Q000648:ultrastructure; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D008264:Macrophages; D008854:Microscopy, Electron; D009470:Muscle Spindles / Q000648:ultrastructure*