Hepatocellular carcinoma, transfusion-induced hemochromatosis and congenital hypoplastic anemia (Blackfan-Diamond syndrome).
A 25 year old patient with congenital hypoplastic anemia (Black-fan-Diamond syndrome) is described. This patient was hepatitis-antigen negative, had not received androgens and had a hepatoma develop in a transfusional hemochromatotic liver. Since androgens have been associated with hepatocellular carcinoma, the use of androgenic steroids for other than life-threatening symptoms in this disease should be avoided.
D000328:Adult; D000728:Androgens / Q000009:adverse effects / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications / Q000151:congenital* / Q000188:drug therapy; D001803:Blood Transfusion; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D004913:Erythrocytes, Abnormal; D006432:Hemochromatosis / Q000150:complications*; D006511:Hepatitis B Antigens; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D013577:Syndrome
D000728:Androgens; D006511:Hepatitis B Antigens