The effect of repeated intramuscular gonadotrophin-releasing hormone injections on luteinizing hormone, follicle-stimulating hormone, testosterone, oestrogens, dehydroepiandrosterone and dehydroepiandrosterone sulfate in normal men.
The endocrine response to three daily intramuscular injections of 500 microgram LH-RH was measured in 9 normal men during a period of 3 days. A marked but declining response in LH was seen in addition to a significant increase in the serum concentration of FSH, testosterone, oestradiol and the urinary excretion of oestrogenic substances. No change could be demonstrated in the DHA, DHAS or cortisol secretion which confirms our previous results of a direct effect of clomiphene on adrenal steroidogenesis.
D000302:Adrenal Cortex / Q000187:drug effects; D000328:Adult; D002996:Clomiphene / Q000494:pharmacology; D003687:Dehydroepiandrosterone / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D004967:Estrogens / Q000652:urine; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007273:Injections, Intramuscular; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood*
D004967:Estrogens; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone