A study of intestinal dipeptidases of rats: effect of in vivo mucosal exposure to vinblastine.
The mucosal population of small intestine of rats was exposed in vivo to various concentrations of vinblastine sulfate for 30 and 60 min and the activities of glycyl-L-valine and glycyl-L-leucine hydrolase were measured in the treated mucosa of the upper jejunal segment. A significant depression in the activity of these dipeptidases was observed which was further found to be dose dependent.
D000818:Animals; D004150:Dipeptidases / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D004150:Dipeptidases