Measurement of fibrinogen degradation products (FDP) in serum of normal and tumor-bearing rats.
The level of serum fibrinogen degradation products (FDP) in rat was quantified by hemagglutination-inhibition immunoassay which utilized anti-rat-fibrinogen antiserum of rabbit and fibrinogen-coated rat erythrocytes. The sensitivity of this method was high enough to detect minute amounts of serum FDP in rats. The normal value ranged from 1.25 to 10 mug/ml with a mean value of 5.7 mug/ml as expressed as fibrinogen equivalents. The changes in FDP level were noted in tumor-bearing rats which were transplanted subcutaneously with 10(6) tumor cells (AH-109A, a strain of Yoshida rat ascites hepatoma). The FDP level was unchanged in an early stage, elevated to 56 mug/ml on 12th day and to 92 mug/ml on 16th day on an average. These elevations were statistically significant.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000097:blood*; D004912:Erythrocytes / Q000276:immunology; D005338:Fibrin Fibrinogen Degradation Products / Q000097:blood*; D005340:Fibrinogen / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007106:Immune Sera; D008113:Liver Neoplasms; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000097:blood; D051381:Rats; D014184:Transplantation, Homologous
D005338:Fibrin Fibrinogen Degradation Products; D007106:Immune Sera; D005340:Fibrinogen