title: Lead. Possible toxicity in urban vs rural rats.
abstract: The degree of lead poisoning in wild rats from two environments has been studied. Wild rats captured in an urban area had markedly elevated tissue lead compared with values in rural rats. This elevation may have been caused by differences in factors affecting absorption of ingested lead or an elevated respiratory exposure to airborne lead, or both, and lead in precipitated dust. Changes in several biologic indexes (depression of delta-amino levulinic acid dehydratase in kidney and red blood cells, presence of renal intranuclear inclusion bodies, and increased kidney weight) confirmed lead-poisoning in urban rats.
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D004781:Environmental Exposure; D005260:Female; D005843:Geography; D006801:Humans; D002479:Inclusion Bodies / Q000166:cytology; D007668:Kidney / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D007854:Lead / Q000032:analysis / Q000633:toxicity; D007855:Lead Poisoning / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D012376:Rodent Diseases / Q000209:etiology*
chemical_list: D007854:Lead; D000623:Porphobilinogen Synthase