Mobilization of sequestered metabolities into degradative reactions by nutritional stress in Neurospora.
The pools of arginine and ornithine rapidly disappear during nitrogen starvation of Neurospora crassa. Much of this disappearance can be accounted for by degradation catalyzed by preexisting catabolic enzymes. Purine degradation is also initiated by nitrogen metabolic stress. Mobilization of these compounds into degradative reactions does not appear to be a general response to nutritional stress since neither carbon starvation nor inhibition of protein synthesis elicits this response. It is suggested that nitrogen starvation may specifically alter the distribution of arginine and ornithine between vesicles and cytosol. This would be sufficient to initiate and maintain their degradation. These result suggest that compartmentation of amino acids provides a metabolic reserve to be utilized during periods of specific nutritional stress.
D001119:Arginase / Q000378:metabolism; D001120:Arginine / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism*; D003470:Culture Media; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism*; D009952:Ornithine / Q000378:metabolism*; D009953:Ornithine-Oxo-Acid Transaminase / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D014508:Urea / Q000096:biosynthesis
D003470:Culture Media; D011687:Purines; D002244:Carbon; D014508:Urea; D001120:Arginine; D009952:Ornithine; D009953:Ornithine-Oxo-Acid Transaminase; D001119:Arginase; D009584:Nitrogen