Irreversible inhibition of herpes simplex virus replication in BSC-1 cells by zinc ions.
Zinc sulfate added to the medium of herpes simplex virus-infected BSC-1 cells, at a concentration of 0.1 mM, inhibited the synthesis of infectious virus progeny by 95 to 96%. A concentration of 0.2 mM zinc sulfate inhibited herpes simplex virus synthesis by 99.8% as determined by centrifugation in sucrose gradients and by plaque assay on BSC-1 monolayers. The inhibition of herpes simplex virus replication in BSC-1 cells was found to be irreversible.
D002460:Cell Line; D002478:Cells, Cultured; D003864:Depression, Chemical; D018139:Simplexvirus / Q000187:drug effects*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology*
D015032:Zinc