[Relationship between lipemia and sensitivity to arachidonic acid in rabbits].
The hypotensive effect of arachidonic acid in the rabbit increases simultaneously with the fall of the plasmatic unesterified fatty acids (NEFA), after treatment with nicotinic acid or heparin. In the case of nicotinic acid sensitization, which occurs in 10 minutes, the fall of NEFA occurs immediately. The sensitization by heparin appears only after 40 minutes following the injection; during this latency, the NEFA are enhanced; after the fall of NEFA, the rabbit becomes more sensitive to arachidonic acid. Mechanisms of heparinic sensitization are discussed.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006493:Heparin / Q000494:pharmacology; D006949:Hyperlipidemias / Q000150:complications / Q000503:physiopathology*; D007022:Hypotension / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D001095:Arachidonic Acids; D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D009539:Nicotinic Acids; D014280:Triglycerides; D006493:Heparin; D002784:Cholesterol
Recherches sur les relations entre lipémie et sensibilité à l'acide arachidonique chez le lapin.