title: Regulation of citrate synthase activity in methylotrophs by reduced nicotinamide-adenine dinucleotide, adenine nucleotides and 2-oxoglutarate.
abstract: Citrate synthase from two typical facultative methylotrophs, but not from four obligate methylotrophs or from two restricted facultative methylotrophs, is inhibited by 0.1 mM-NADH. ATP or ADP (both at 10mM) inhibits all the citrate synthases, whereas 2-oxoglutarate (10mM) inhibits those from only three of the eight methylotrophs.
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology; D001419:Bacteria / Q000201:enzymology*; D002950:Citrate (si)-Synthase / Q000037:antagonists & inhibitors*; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D008772:Methylococcaceae / Q000201:enzymology; D009243:NAD / Q000494:pharmacology; D007652:Oxo-Acid-Lyases / Q000037:antagonists & inhibitors*; D011549:Pseudomonas / Q000201:enzymology
chemical_list: D000227:Adenine Nucleotides; D007656:Ketoglutaric Acids; D009243:NAD; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D002950:Citrate (si)-Synthase; D007652:Oxo-Acid-Lyases