Effects of apolipoproteins on lipoprotein lipase activity of human adipose tissue.
The effect of apolipoproteins isolated from HDL and VLDL on the activity of lipoprotein lipase (LPL) of adipose tissue was studied. The CII apoprotein was found to activate LPL. This activation was strongly inhibited by CI, AI (apo-Lp-Gln I), and the arginine-rich apoprotein, whereas AII and CIII exhibited a considerably lower inhibitor effect.
D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D001059:Apoproteins / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000097:blood / Q000494:pharmacology*
D001059:Apoproteins; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D008071:Lipoprotein Lipase