Effect of ubiquinone-homologs on the sensitivity of mitochondrial ATPase to energy transfer inhibitors.
Short-chain ubiquinone (UQ-3) abolishes oligomycin sensitivity of ATPase in submitochondrial particles and the effect is reversed by long-chain ubiquinone (UQ-7). Ubiquinone-3 also abolishes DCCD sensitivity of ATPase in submitochondrial particles but the effect is not reversed by long-chain ubiquinones. These data suggest that ubiquinone interferes with energy transfer process by interaction with mitochondrial ATPase.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology; D009840:Oligomycins / Q000494:pharmacology; D014451:Ubiquinone / Q000494:pharmacology*
D009840:Oligomycins; D014451:Ubiquinone; D000251:Adenosine Triphosphatases