Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A.
Urinary excretion of cyclic guanosine monophosphate (GMP) increased in rats bearing Morris hepatoma 3924A, and a correlation coefficient of .842 was observed comparing nucleotide excretion and tumor size. Irradiation of tumor or 5-fluorouracil administration delayed the increases in urinary cyclic GMP and tumor size. Surgical removal of tumors resulted in a rapid decline in cyclic GMP excretion to baseline levels. Cyclic adenosine monophosphate excretion was not altered by implantation, irradiation, or excision of tumor.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000652:urine*; D000242:Cyclic AMP / Q000652:urine; D006152:Cyclic GMP / Q000652:urine*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000652:urine*; D009374:Neoplasms, Experimental / Q000652:urine; D051381:Rats; D011912:Rats, Inbred ACI; D014965:X-Rays
D000242:Cyclic AMP; D006152:Cyclic GMP; D005472:Fluorouracil