title: Ultrastructural changes in bovine lingual epithelium infected with vesicular stomatitis virus.
abstract: Vesicular stomatitis virus was inoculated into the dorsal lingual epithelium of three cows. The reaction that developed in 72 h was characterized by severe acute diffuse glossitis with intercellular edema and necrosis of keratinocytes. Virions budded from the plasma membrane and were in the intercellular spaces. Reduplication of desmosomes was a prominent alteration, and normal desmosomes were within the cytoplasm. Intracytoplasmic desmosomes appeared to be formed by endocytosis after breaks occurred in the plasma membrane of one cell; endocytosis of loops of plasma membrane containing desmosomes; and formation of desmosomes on invagination of the plasma membrane.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D003896:Desmosomes / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D008933:Mitochondrial Swelling; D013280:Stomatitis / Q000473:pathology / Q000662:veterinary*; D014059:Tongue / Q000648:ultrastructure*; D014617:Vacuoles / Q000648:ultrastructure; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000473:pathology / Q000662:veterinary