[Effect of L-eburnamonine on bronchial respiratory resistance in the anesthetized guinea pig. Comparison with vincamine].
In anesthetized guinea pigs, i.v. injection of l-eburnamonine (l-E) induced a moderate constriction of bronchia. This bronchoconstriction was partially antagonized by atropine and brompheniramine and nearly completely inhibited by papaverine; methysergide was devoid of antagonistic activity. It was suggested that the contractive activity of l-E is complex and not specific. Similar results were obtained with vincamine (Vi) but vincamine's bronchoconstriction was not completely inhibited by papaverine. Furthermore, the bronchoconstrictor activity of Vi was more important and more durable than that of l-E.
D000403:Airway Resistance / Q000187:drug effects*; D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001977:Brompheniramine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D001986:Bronchial Spasm / Q000139:chemically induced; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014749:Vincamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D014748:Vinca Alkaloids; D001285:Atropine; D014749:Vincamine; D010208:Papaverine; D001977:Brompheniramine; D008784:Methysergide
Action de la l'éburnamonine sur la résistance des bronches à l'insufflation chez le cobaye anesthésié. Comparaison avec la vincamine.