title: Treating perforated jejunal ulcer, a complication in the Zollinger-Ellison syndrome.
abstract: What is considered to represent the fourth case of perforated jejunal ulcer in association with the Zollinger-Ellison syndrome reported in the literature is discussed. Although documented in the original paper by Zollinger and Ellison, this remains a notably rare complication. Generalized peritonitis and related pathophysiological phenomena make initial definitive correction of the ulcer diathesis an extremely riskly undertaking and ill-advised. We submit that primary ulcer resection followed by total gastrectomy when the patient becomes a more suitable operative risk is the preferred method of management. The literature would appear to support this clinical view.
mesh_terms: D007516:Adenoma, Islet Cell / Q000601:surgery; D004379:Duodenal Neoplasms / Q000601:surgery; D005743:Gastrectomy; D005755:Gastrins / Q000097:blood; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000209:etiology / Q000601:surgery*; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000150:complications* / Q000601:surgery
chemical_list: D005755:Gastrins