title: Comparisons of antidotal efficacy of chelating drugs upon acute toxicity of Ni(II) in rats.
abstract: Six chelating drugs were administered to rats by im injection at equimolar dosages in order to compare their relative effectiveness in prevention of death after a single parenteral injection of NiCl2. Triethylenetetramine and d-penicillamine were most effective antidotes for acute Ni (II)-toxicity. In order of decreasing antidotal effectiveness, diglycyl-L-histidine-N-methylamide, sodium diethyldithiocarbamate and calcium disodium versenate significantly reduced the acute mortality of rats following ip injection of Ni (II). Alpha-Lipoic acid was not effective as an antidote for acute Ni (II)-toxicity.
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use*; D004050:Ditiocarb / Q000627:therapeutic use; D004492:Edetic Acid / Q000627:therapeutic use; D005029:Ethylenediamines / Q000627:therapeutic use; D005260:Female; D007928:Lethal Dose 50; D009532:Nickel / Q000506:poisoning* / Q000633:toxicity; D009842:Oligopeptides / Q000627:therapeutic use; D010396:Penicillamine / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D008063:Thioctic Acid / Q000627:therapeutic use
chemical_list: D000931:Antidotes; D002614:Chelating Agents; D005029:Ethylenediamines; D009842:Oligopeptides; C012285:diglycyl-histidine-N-methylamide; D008063:Thioctic Acid; D009532:Nickel; D004050:Ditiocarb; D004492:Edetic Acid; D010396:Penicillamine