Pancreatic cholera: beneficial effects of treatment with streptozotocin.
Two patients with pancreatic cholera and islet-cell carcinoma were treated with intra-arterial streptozotocin. Before therapy, they had stool volumes from 2 to 8 liters per day and required 200 to 800 mEq per day of supplemental potassium. After three to five doses of streptozotocin (1.5 per square meter), both stool volume and number and size of hepatic metastases decreased markedly. One patient has had normally formed stools for 12 months; the other had a 90 per cent reduction in stool volume for 13 months with additional therapy. Both patients' serum potassium returned to normal without need for supplementation. Jejunal adenylate cyclase activity was normal in both, and plasma vasoactive intestinal peptide was detectable in only one. After chemotherapy, these findings showed no consistent change. Pharmacologic studies suggest that arterial administration increased either tumor or hepatic extraction (or both) of streptozotocin by two times and decreased renal exposure to this nephrotoxic drug by one third.
D000126:Achlorhydria / Q000150:complications; D007516:Adenoma, Islet Cell / Q000150:complications* / Q000503:physiopathology; D000262:Adenylyl Cyclases / Q000378:metabolism; D002771:Cholera / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism; D006801:Humans; D007008:Hypokalemia / Q000188:drug therapy / Q000209:etiology; D007269:Injections, Intra-Arterial; D007413:Intestinal Mucosa / Q000201:enzymology; D007583:Jejunum / Q000201:enzymology; D008113:Liver Neoplasms / Q000150:complications; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000503:physiopathology; D010455:Peptides / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D013311:Streptozocin / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D013577:Syndrome
D005768:Gastrointestinal Hormones; D010455:Peptides; D013311:Streptozocin; D000262:Adenylyl Cyclases; D011188:Potassium