[Effect of ACTH on glucose-6-phosphate dehydrogenase and transketolase activity in mitochondria and hyaloplasm of rabbit liver].
The glucose-6-phosphate dehydrogenase and transketolase activities in mitochondria and hyaloplasm of the rabbit liver were studied as affected by ACTH injected daily in a dose of 10 u/kg of weight for two weeks. It was shown that the activity of glucose-6-phosphate dehydrogenase was unchanged neither in mitochondria nor in hyaloplasm. The transketolase activity in hyaloplasm was not changed as well. But in mitochondria it decreases by 47% (by an increase of sedoheptulose-7-phosphate S-7-P) simultaneously the ribose-5-phosphate (R-5-P) conversion is inhibited by 35%. The ratio of converted R-5-P and formed S-7-P became 2:0.68 (instead of theoretical 2:1). Administration of ACTH has no effect on the total concentration of acid-soluble ribose-containing compounds in both mitochondria and hyaloplasm.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003593:Cytoplasm / Q000187:drug effects / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D011817:Rabbits; D014174:Transketolase / Q000378:metabolism*
D000324:Adrenocorticotropic Hormone; D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase
Vpliv AKTG na gliukozo-6-fosfatdegidrogenaznui transketolaznu aktivnosti mitokhondriĭ ta gialoplazmi pechinki kroliv