title: Down's syndrome, hypothyroidism and diabetes mellitus in an adult.
abstract: Primary hypothyroidism was diagnosed in a woman aged 33 years, with Down's syndrome and insulin-dependent diabetes mellitus after admission to hospital with hypoglycaemia. The diabetes was stabilized and treatment was commenced with L-thyroxine with a good clinical response. The patient's mother and older sister also had hypothyroidism and all three had no thyroid antibodies. The importance of diagnosing and treating primary hypothyroidism in adult patients with Down's syndrome is stressed even in the absence of thyroid antibodies.
mesh_terms: D000328:Adult; D048909:Diabetes Complications; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D007328:Insulin; D013974:Thyroxine