Enzyme inhibition in colorectal surgery.
Anastomotic dehiscence is particularly common after low anterior resection of the rectum. The enzyme collagenase is largely responsible for this high complication rate. Inhibition of this enzyme in an experimental model produced significantly stronger colonic anastomoses. There may be a place for such an inhibitor in clinical surgery.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D005260:Female; D008297:Male; D003012:Microbial Collagenase / Q000378:metabolism*; D011817:Rabbits; D012007:Rectum / Q000601:surgery*; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*
D007611:Aprotinin; D003012:Microbial Collagenase