[Effects of theophylline on chemically induced liver tumorogenesis and on bladder membranes in rats].
The addition of theophylline to the diet of rats given the carcinogen 4-dimethylaminoazobenzene did not significantly impair the development of hepatomas. In contrast, the feeding of theophylline has been associated to some histopathological changes in bladder membrane leading to the occurrence of malignant papillomas.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D003864:Depression, Chemical; D005247:Feeding Behavior / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D004124:p-Dimethylaminoazobenzene / Q000037:antagonists & inhibitors*
D004124:p-Dimethylaminoazobenzene; D013806:Theophylline
Effets de la théophylline sur l'hépatocancérogenèse induite par agent chimique et sur la membrane vésicale, chez le Rat