Effect of ipratropium bromide and fenoterol on airway obstruction in chronic pulmonary tuberculosis.
Single-blind, cross-over comparison of standard doses of ipratropium bromide (2 puffs of 0.02 mg each) and fenoterol (2 puffs of 0.2 mg each) in 36 pairs of experiments in 6 patients with partially reversible airway obstruction, presumably secondary to chronic widespread pulmonary tuberculosis, revealed no difference between the drugs in bronchodilating effect, evaluated by peak-flow measurements and spirometry. The inhalation of isoprenaline at the end of the experiment induced no further improvement in the lung function variables measured. The results suggest that a vagal reflex mechanism plays a major role in bronchoconstriction connected with severe chronic pulmonary tuberculosis.
D000328:Adult; D000336:Aerosols; D000402:Airway Obstruction / Q000150:complications / Q000188:drug therapy*; D001286:Atropine Derivatives / Q000627:therapeutic use*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000627:therapeutic use*; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D007545:Isoproterenol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000503:physiopathology; D014630:Vagus Nerve / Q000502:physiology
D000336:Aerosols; D001286:Atropine Derivatives; D004983:Ethanolamines; D005280:Fenoterol; D009241:Ipratropium; D007545:Isoproterenol