Prenatal diagnosis of placental sulphatase deficiency.
A gas chromatographic procedure for the quantitation of neutral steroid sulphates in maternal urine and its application to a suspected case of placental sulphatase deficiency is described. Low levels of oestriol coincident with elevated 16-hydroxylated metabolites of dehydroepiandrosterone in the maternal urine are shown to occur in this particular condition, and thus provide a convenient differentiation from fetal adrenal hypoplasia before birth.
D000734:Androstenediols / Q000652:urine; D000737:Androstenols / Q000652:urine; D001192:Arylsulfatases / Q000172:deficiency*; D002849:Chromatography, Gas / Q000379:methods; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005965:Glucuronates; D006801:Humans; D006868:Hydrolysis; D007231:Infant, Newborn; D008297:Male; D009596:Nitrophenols; D010922:Placenta Diseases / Q000175:diagnosis* / Q000652:urine; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013429:Sulfatases / Q000172:deficiency*
D000734:Androstenediols; D000737:Androstenols; D005965:Glucuronates; D009596:Nitrophenols; C007421:3 beta,17 beta-dihydroxyandrost-5-en-16-one; C011277:16-hydroxydehydroepiandrosterone; C006577:5-androstene-3,16,17-triol; D003687:Dehydroepiandrosterone; D013429:Sulfatases; D001192:Arylsulfatases