[Diminution of blood and hepatic cholesterol induced by an apple-supplemented diet in the hamster. Trials in man].
The effects of an apple-supplemented diet on plasma and liver cholesterol were investigated in two strains of Hamster, a normal one and another which exhibits a spontaneous accumulation of cholesteryl esters in the liver (FEC animals). Adding of apples to the standard diet promoted a 20 % decrease of cholesterolemia in normal animals and normalized the high level of plasma cholesterol in the FEC animals. Similarly, the cholesterol content of the liver was diminished. The levels of cholesteryl esters were strongly lowered, threefold and tenfold respectively in normal and in FEC animals. Incorporation of labelled mevalonate into cholesterol was increased, but esterification of the neosynthesized sterol was markedly reduced in the liver from FEC animals. In human daily ingestion of apples caused a significative reduction (16 %) of cholesterolemia.
D000328:Adult; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000096:biosynthesis; D006224:Cricetinae; D004032:Diet; D005638:Fruit; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008875:Middle Aged
D002788:Cholesterol Esters; D002784:Cholesterol
Diminution du cholestérol sanguin et hépatique induite chez le hamster par un régime alimentaire complémenté en pommes. Essais chez l'Homme.