Acceleration of transformation of rat embryo cells by rat type C virus.
Sprague-Dawley and Fischer rat embryo cells became spontaneously transformed about 20 passages after release of endogenous ecotropic type C virus (SD-RaLV and F-RaLV). The virus-producing transformed cells showed loss of contact inhibition, increased growth rate, and tumorigenicity in vivo. Exogenous infection of other Fischer rat embryo cultures in early passage with SD-RaLV and F-RaLV markedly accelerated their rates of transformation.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D003260:Contact Inhibition; D046508:Culture Techniques; D005347:Fibroblasts; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology; D051381:Rats; D012190:Retroviridae / Q000254:growth & development* / Q000276:immunology; D014779:Virus Replication
D000956:Antigens, Viral