[Supppression of paradoxical sleep by chloramphenicol. Absence of effect by thiamphenicol].
The oral administration of 160-250 mg/kg of chloramphenicol selectively suppresses Paradoxical Sleep in the cat for a duration of 10-20 hours. Larger doses (330 mg/kg) suppress Paradoxical Sleep for 27 hours, but aslso decrease Slow Wave Sleep. At the same dose, Thiamphenicol has no effect.
D000818:Animals; D002415:Cats; D002701:Chloramphenicol / Q000494:pharmacology*; D004569:Electroencephalography; D005260:Female; D008297:Male; D012895:Sleep, REM / Q000187:drug effects*; D013839:Thiamphenicol / Q000494:pharmacology; D013997:Time Factors
D002701:Chloramphenicol; D013839:Thiamphenicol
Suppression du sommeil paradoxal par le chloramphénicol chez le chat. Absence d'effet du thiamphénicol