The mechanism of alloxan toxicity: an indication for alloxan complexes in tissues and alloxan inhibition of 4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulphonic acid (SITS) binding for the liver cell membrane.
It is shown that alloxan inhibits binding of SITS to liver cells. This indicates the cell membrane as a site of alloxan action. Alloxan is found to react with tissues to form complexes that are detectable up to 3 hrs after alloxan treatment. On the basis of the present findings, an assumption is made that alloxan inhibits a cell membrane processes by blockade of functionally importnat groups.
D000496:Alloxan / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005456:Fluorescent Dyes / Q000378:metabolism; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D051381:Rats; D013267:Stilbenes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013451:Sulfonic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism; D013861:Thiocyanates / Q000037:antagonists & inhibitors / Q000378:metabolism
D005456:Fluorescent Dyes; D013267:Stilbenes; D013451:Sulfonic Acids; D013861:Thiocyanates; D009243:NAD; D000496:Alloxan