[Effect of beryllium salts on the activity of sarcoplasmic reticulum Ca2+,Mg2+-dependent ATP-ase].
In the presence of Mg2+ and Ca2+ ions beryllium compounds inhibit the Ca2+, Mg2+-dependent ATPase activity and the transport of Ca2+ in the sarcoplasmatic reticulum vesicles. The inhibition is reversible and concurrent with respect to the Mg2+ ions. In the absence of the Mg2+ ions an addition of beryllium compounds stimulates the ATPase activity, the dependence of the degree of its stimulation on the beryllium compounds concentration is characterized by a curve with a maximum. On the membranous Ca2+, Mg2+-dependent ATPase preparations beryllium compounds produce a stronger inhibiting effect than in the case of the purified enzyme, which is, apparently, due to their ability to influence the membranous structure. The hydrophobic spin probe method shows that beryllium compounds reduce the microviscosity of the lipid sections of the membrane.
D000818:Animals; D001608:Beryllium / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000494:pharmacology
D013431:Sulfates; D000252:Calcium-Transporting ATPases; D008274:Magnesium; D001608:Beryllium; D002118:Calcium
Vliianie soleĭ berilliia na aktivnost' Ca2+,Mg2+-zavisimoĭ ATF-azy sarkoplazmaticheskogo retikuluma.