[Effect of sodium salicylate on the "in vitro" development of RNA viruses (author's transl)].
Sodium salicylate 10(-3) M is able to limit the number of plaques induced by RNA viruses on monkey kidney cell cultures (Cercopithecus aethiops and Macaccus rhesus). However, the inhibition rate changes with the virus type or even the strain used. Poliovirus 2, Coxsackie B3, echovirus and reovirus 1 were the most susceptible to the inhibitory effect of the drug. Latent infection caused by SV5 decreases the antiviral activity of salicylate. The stages of the poliovirus type 2 growth affected by sodium salicylate, were studied. The drug has no direct activity on the infectivity of the virus. It decreases adsorption and penetration. In spite of heavy virus concentration (10(-5,5) to 10(-7)) ID/ml) the eclipse phase is delayed about 3 hours. After 6 hours, viral maturation proceeds and reaches the same level as the controls, and virus quantities recovered are equivalent after 12 hours. Viral infectious RNA fails to induce plaques on salicylate treated cultures. The drug seems to act during the eclipse phase.
D000261:Adenoviruses, Simian; D002478:Cells, Cultured; D004770:Enterovirus / Q000254:growth & development; D029822:Enterovirus B, Human / Q000254:growth & development; D017955:Poliovirus / Q000254:growth & development; D012328:RNA Viruses / Q000187:drug effects / Q000254:growth & development*; D012087:Reoviridae / Q000254:growth & development; D012980:Sodium Salicylate / Q000494:pharmacology*; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
D012980:Sodium Salicylate
Action du salicylate de sodium sur le développement in vitro de virus à acide ribonucléique