[Different action of alpha-methyl-DOPA on sleep and labyrinth learning in 2 inbred strains of mice].
In two inbred mice strains C 57 BR and C 57 BL/6 presenting the same type of sleep, but a different capacity of learning, Alpha-Methyl-Dopa (100 mg/kg) injected after every session, suppresses paradoxical sleep completely for 9 to 11 h. Maze-learning performance is retarded in C 57 BR mice, but facilitated in C 57 BL/6.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000502:physiology*; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D008750:Methyldopa
Action différente de l'alpha-méthyl-DOPA sur le sommeil et l'acquisition d'un labyrinthe chez deux souches consanguines de souris