Hereditary hemorrhagic telangiectasia. A case with hepatocellular carcinoma and acquired hepatocerebral degeneration.
A patient with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease), treated with ethinyl estradiol, multiple blood transfusions, and iron-dextran, developed hepatocellular carcinoma and acquired hepatocerebral degeneration. In addition to the carcinoma, the liver contained extensive arteriovenous maliformations, telangiectasis, and changes of Osler atypical cirrhosis. The carcinoma possibly had its genesis in the presence of an ocongenic serum hepatitis virus, or the cirrhosis, or both.
D000368:Aged; D001165:Arteriovenous Malformations / Q000150:complications; D001219:Aspartate Aminotransferases / Q000097:blood; D001344:Autopsy; D001803:Blood Transfusion; D001806:Blood Urea Nitrogen; D001921:Brain / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D007505:Iron-Dextran Complex / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications* / Q000628:therapy
D004997:Ethinyl Estradiol; D007505:Iron-Dextran Complex; D001219:Aspartate Aminotransferases