On the effect of N-methyl-bis (3-mesyloxypropyl) amine hydroxychloride on Bacillus subtilis cells.
N-Methyl-bis (3-mesyloxypropyl)amine hydrochloride is now in use as an antitumer drug. In view of its activity against some bacteria the present work was conducted to study its mode of action of Bacillus subtilis. The compound was found to induce irreversible damage to bacterial DNA whereas its effect on RNA was temporary and depending on maintenance of effective concentrations of the compound.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D004269:DNA, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D008698:Mesylates / Q000494:pharmacology*; D012329:RNA, Bacterial; D013696:Temperature; D013997:Time Factors
D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D008698:Mesylates; D012329:RNA, Bacterial