[The effect of gonadotropic hormones and the fetal hypophysis on testosterone production by the testis of 18 day mouse fetuses in organ culture].
The production of testosterone (measured by radioimmuno-assay) by the 18-day-old mouse fetal testis may be stimulated specifically by ovine LH (1 ng, p less than 0.005) and HCG in organ culture. A stimulation by FSH is observed only with high doses (10 mug, p less than 0.0005). Prolactin and ACTH have no effect. Age-matched fetal pituitaries increase significantly the testosterone production in the culture medium (p less than 0.0005).
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D006063:Chorionic Gonadotropin; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D006062:Gonadotropins / Q000494:pharmacology*; D006065:Gonadotropins, Pituitary / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D011388:Prolactin / Q000494:pharmacology; D011863:Radioimmunoassay; D013268:Stimulation, Chemical; D013737:Testis / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis*
D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D006065:Gonadotropins, Pituitary; D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Influence des hormones gonadotropes et de l'hypophyse foetale sur la production de testostérone par le testicule foetal de souris de 18 jours en culture organotypique