Effects of short chain alcohols and hydrocarbon compounds on the adenylate cyclase of the skin.
The cyclic AMP content of epidermal slices is increased by incubation with ethanol, the effect of which is dose-dependent from I to 5% concentration in the incubation media. n-Propanol and acetone are also effective at a concentration equimolar to 5% ethanol. Experimental results suggest that this effect of ethanol is due to activation of adenylate cyclase, rather than to the inactivation of cyclic AMP-phosphodiesterase.
D000433:1-Propanol / Q000494:pharmacology; D000096:Acetone / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D000432:Methanol / Q000494:pharmacology; D012867:Skin / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D013552:Swine; D013806:Theophylline / Q000494:pharmacology
D000096:Acetone; D000431:Ethanol; D000433:1-Propanol; D013806:Theophylline; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000432:Methanol; D004837:Epinephrine