[The ultrastructure of pancreatic beta cells in dithizone diabetes and its prevention by sodium diethyldithiocarbamate].
Administration of a nondiabetogenic complex-former-sodium diethyldithiocarbamate (SDEDTC) to rabbits prevented the appearance in beta-cells of the insular apparatus of histological and ultramicroscopic changes with the subsequent administration of a potent diabetogenic agent-ditisone. SDEDTC blocked the insular zinc and prevented ditisone from forming in the islets a complex with this metal producing a destructive action of beta-cells.
D000818:Animals; D001391:Azo Compounds / Q000037:antagonists & inhibitors*; D004230:Dithizone / Q000037:antagonists & inhibitors*; D004050:Ditiocarb / Q000627:therapeutic use*; D007515:Islets of Langerhans / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011817:Rabbits; D051381:Rats; D013859:Thiocarbamates / Q000627:therapeutic use*
D001391:Azo Compounds; D013859:Thiocarbamates; D004230:Dithizone; D004050:Ditiocarb
Ul'trastruktura pankreatincheskikh beta-kletok pri ditizonovom diabete i ego preduprezhdenie diétilditiokarbamatom natriia