[C14-variamycin content in normal and tumorous brain tissues of white rats].
Penetration of variamycin, a new antitumor antibiotic into the normal and tumor tissues of the brain of rats with multiform glioblastoma was investigated. The content of the C14-labeled antibiotic was determined radiometrically. The radioactive label penetrated into the normal and tumor tissues of the brain during the first hours after the drug administration. The level of the radioactivity in the tumor tissue was higher than that in the normal brain tissue during the whole period of the study. The greatest deviation in the contents of the radioactive label in the tumor and normal tissues was observed 2 and 3 hours after administration of the labeled antibiotic, i. e. 4.3 and 3.6 times respectively.
D000818:Animals; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000032:analysis*; D002250:Carbon Radioisotopes; D005909:Glioblastoma / Q000032:analysis; D009368:Neoplasm Transplantation; D008926:Plicamycin / Q000031:analogs & derivatives* / Q000032:analysis; D051381:Rats; D012588:Scintillation Counting; D013997:Time Factors
D002250:Carbon Radioisotopes; C009950:variamycin; D008926:Plicamycin
Soderzhanie C14-variamitsina v normal'noĭ i opukholevoĭ tkaniakh golovnogo mozga belykh krys