title: A study of intestinal dipeptidases of rats: effect of in vivo mucosal exposure to vinblastine.
abstract: The mucosal population of small intestine of rats was exposed in vivo to various concentrations of vinblastine sulfate for 30 and 60 min and the activities of glycyl-L-valine and glycyl-L-leucine hydrolase were measured in the treated mucosa of the upper jejunal segment. A significant depression in the activity of these dipeptidases was observed which was further found to be dose dependent.
mesh_terms: D000818:Animals; D004150:Dipeptidases / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology*
chemical_list: D014747:Vinblastine; D004150:Dipeptidases