[Use of the macrophage-electrophoretic-mobility test in the diagnosis of tumours of the central nervous system (author's transl)].
The macrophage-electrophoretic-mobility (MEM) tests of Field and Caspary demonstrates the macrophage-slowing factor (MSF) produced by specifically sentised blood lymphocytes after incubation with the homologous antigen. Besides other diseases with a cellular immune reaction like multiple sclerosis malignant tumours show a reduction of the macrophage mobility in the cell electrophoresis. A significant inhibition in the MEM- test was found in 30 out of  33 tumours of the CNS. Glioblastomas, astrocytomas, spongioblastomas, ependymomas, neurinomas, meningiomas, and a myxofibroma showed a positive result (more than 10% inhibition). The results in ectodermal tumours (pituitary adenoma, craniopharyngioma) differed; secondary brain tumours showed the greatest inhibition.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis; D002493:Central Nervous System Diseases / Q000175:diagnosis; D003397:Craniopharyngioma / Q000175:diagnosis; D004586:Electrophoresis; D004806:Ependymoma / Q000175:diagnosis; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis; D006801:Humans; D007158:Immunologic Techniques; D008264:Macrophages; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis; D009442:Neurilemmoma / Q000175:diagnosis; D009455:Neurofibroma / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000175:diagnosis; D013997:Time Factors
Zur Bedeutung des Makrophagen-Elektrophorese-Mobilitätstests für die Diagnostik der Geschwülste des Zentralnervensystems