title: Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells.
abstract: Cells derived from tumors induced in "nude" mice after injection of cells that were hybrids between mouse peritoneal macrophages and simian virus 40 (SV40)-transformed human cells were found to retain the human chromosome 7 carrying the SV40 genome, and indicate that the presence of human chromosome 7 carrying the SV40 genome is responsible for the expression of the tumorigenic phenotype in the hybrid cells.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002906:Chromosomes, Human, 6-12 and X / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D005347:Fibroblasts / Q000032:analysis; D006801:Humans; D006822:Hybrid Cells / Q000032:analysis*; D007621:Karyotyping; D007926:Lesch-Nyhan Syndrome; D008264:Macrophages; D051379:Mice; D008810:Mice, Inbred C57BL; D013539:Simian virus 40 / Q000032:analysis*
chemical_list: D004279:DNA, Viral