In vitro detection of immune responses to MTV-induced mammary tumors: qualitative differences in response detected by time studies.
Both BALB/cfC3H females neonatally infected with mammary tumor virus (MTV) and MTV-free BALB/c females possess spleen cells capable of significant activity against target-MTV-induced mammary tumor cells in in vitro microcytotoxicity tests. The responses of the BALB/cfC3H and BALB/c females are different, however, on the basis of time studies. Further, the reactivity characteristic of virgin BALB/cfC3H females is increased in parous females, and part of this reactivity is subsequently lost in multiparous females bearing large tumors. BALB/cfC3H females possess reactive spleen cells as early as 3 weeks of age, indicating that response to MTV antigens develops soon after birth in these neonatally infected mice.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000951:Antigens, Neoplasm; D002470:Cell Survival; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007106:Immune Sera; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009366:Neoplasm Seeding; D010298:Parity; D013154:Spleen / Q000166:cytology
D000951:Antigens, Neoplasm; D007106:Immune Sera