[The condition of mitochondria in experimental viral carcinogenesis].
A parallel histoenzymatic and electron-microscopy study of the state of mitochondria in experimental viral cancerogenesis induced by adenovirus of monkeys SA7(C8) and virus of Rous sarcoma in soft tissues of hamster was carried out. It was shown that the earliest changes in the cell in the process of its tumorous transformation were those in mitochondria. The character of deposits of diformazin at an early stage of viral cancerogenesis corresponded to the trend to the linear arrangement of mitochondria and to initial phenomena of their swelling. Progressive swelling of mitochondria in the process of tumorous growth was established, which correlated with histochemically revealed changes in the relationships of a number of reduction-oxidation enzymes.
D000256:Adenoviridae; D000261:Adenoviruses, Simian; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006224:Cricetinae; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006393:Hemangiopericytoma / Q000209:etiology / Q000473:pathology*; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology / Q000648:ultrastructure*; D009374:Neoplasms, Experimental / Q000473:pathology; D001357:Sarcoma, Avian / Q000473:pathology*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase
O sostoianii mitokhondriĭ pri éksperimental'nom virusno kantserogeneze