title: Lobular carcinoma of the breast: a special variant of mucin-secreting carcinoma.
abstract: There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The same histochemical features are seen in the infiltrative phase of the tumour. These findings invalidate the concept that it is a myoepithelial-cell tumour. Practical applications of the distinctive pattern of mucin secretion are discussed.
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002278:Carcinoma in Situ / Q000378:metabolism / Q000473:pathology*; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase; D009077:Mucins / Q000378:metabolism; D009439:Neuraminidase
chemical_list: D009077:Mucins; D009439:Neuraminidase; D006821:Hyaluronoglucosaminidase