title: [On the effect of methane-bis--phosphonate in vivo (author's transl)].
abstract: After s.c. injections of methane-bis-phosphonate into rabbits, calcified incrustations developed around the injection sites. These incrustations were less radiolucent than the surrounding tissues. They appeared to have a good crystalline apatite structure in X-ray diffraction. The findings agree with our previous in vitro studies but disagree with the findings in the literature that ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethyle-nediphosphonate (Cl2MDP) inhibit crystal growth of apatite already formed.
mesh_terms: D000818:Animals; D001031:Apatites / Q000032:analysis; D002114:Calcinosis / Q000139:chemically induced*; D004002:Clodronic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000494:pharmacology; D004164:Diphosphonates / Q000009:adverse effects*; D012968:Etidronic Acid / Q000494:pharmacology; D007279:Injections, Subcutaneous; D011817:Rabbits; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D004164:Diphosphonates; D004002:Clodronic Acid; D012968:Etidronic Acid
vernacular_title: Zur Wirkung von Methan-bis-phosphonsäure in vivo.