Independent constitutive expression of the aerobic and anaerobic pathways of glycerol catabolism in Klebsiella aerogenes.
Klebsiella aerogenes dissimilates glycerol aerobically via an inducible pathway initiated by an adenosine triphosphate-linked kinase that converts the substrate to sn-glycerol 3-phosphate. Phosphorylated glycerol is then dehydrogenated to dihydroxyacetone phosphate by an enzyme characteristic of a flavoprotein. Anaerobically, the organism dissimilates glycerol via an inducible pathway initiated by a nicotinamide adenine dinucleotide-linked dehydrogenase that converts the substrate to dihydroxyacetone. The keto product is then phosphorylated by another adenosine triphosphate-linked kinase. Two kinds of constitutive mutants have been isolated: one affecting the aerobic and the other the anaerobic pathway.
D000332:Aerobiosis; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000693:Anaerobiosis; D002364:Caseins / Q000378:metabolism; D002474:Cell-Free System; D000242:Cyclic AMP / Q000494:pharmacology; D004098:Dihydroxyacetone / Q000378:metabolism; D004754:Enterobacter / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000378:metabolism*; D004794:Enzyme Repression; D005947:Glucose / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism*; D005991:Glycerol Kinase / Q000378:metabolism; D005994:Glycerophosphates / Q000096:biosynthesis; D009154:Mutation; D010770:Phosphotransferases / Q000378:metabolism
D002364:Caseins; D005994:Glycerophosphates; D000242:Cyclic AMP; D000429:Alcohol Oxidoreductases; D005954:Glucosephosphate Dehydrogenase; D010770:Phosphotransferases; D005991:Glycerol Kinase; D005947:Glucose; D004098:Dihydroxyacetone; D005990:Glycerol