Effect of gastro-entero-pancreatic endocrine hormones on the histogenesis of gastric cancer in rats induced by N-methyl-N'-nitro-N-nitrosoguanidine; with special reference to development of scirrhous gastric cancer.
One of five gastro-entero-pancreatic hormones, gastrin, serotonin, histamine, glucagon, and insulin, was intraperitoneally administered for a long period to the rats that received N-methy-N'-nitro-N-nitrosoguanidine. A frequent development of scirrhous carcinoma was demonstrated in the group treated with gastrin.
D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced / Q000473:pathology; D002293:Adenocarcinoma, Scirrhous / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D005755:Gastrins / Q000009:adverse effects*; D005934:Glucagon / Q000009:adverse effects; D006632:Histamine / Q000009:adverse effects*; D007328:Insulin / Q000009:adverse effects; D008297:Male; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental; D009604:Nitrosoguanidines; D010187:Pancreatic Hormones / Q000009:adverse effects*; D051381:Rats; D012701:Serotonin / Q000009:adverse effects*; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D005755:Gastrins; D007328:Insulin; D009604:Nitrosoguanidines; D010187:Pancreatic Hormones; D008769:Methylnitronitrosoguanidine; D012701:Serotonin; D006632:Histamine; D005934:Glucagon