Comparative study of the gamma-radiation-induced changes in the tissular levels of acyclic and cyclic adenosine phosphates.
Periodical measurement of total adenosine phosphates and cAMP in liver, intestinal mucosa and brain carried out in rats after irradiation with either 500 rads or 750 rads generally revealed high intratissular levels of these compounds, suggesting both a stimulated cellular synthesis and an abnormal redistribution in different tissues. The most interesting findings were those regarding the brain considering their close relationships with the clinical evolution of the animals and other previously described biochemical observations.
D000249:Adenosine Monophosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000378:metabolism / Q000528:radiation effects; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D011830:Radiation Effects; D051381:Rats
D003037:Cobalt Radioisotopes; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D000242:Cyclic AMP