Hepatic carbamyl phosphate synthetase and ornithine transcarbamylase in mouse influenze A and influenze B infection.
In mice infected with mouse-adapted influenza A/PR/8/34, hepatic carbamyl phosphate synthetase (CPS) activity was reduced to 88%, and ornithine transcarbamylase (OTC) was reduced to 83% of control values. In mice infected with mouse-adapted B/Lee/40, CPS activity was 98% was 94% of control values. These limited reductions in enzyme activity were attributed to a nonspecific debilitating effect of acute influenzal pneumonia. These findings suggest that the pronounced reduction of CPS and OTC activities reported in Reye's syndrome in man are not a general manifestation of the severity of influenza infection.
D000328:Adult; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001927:Brain Diseases / Q000209:etiology*; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism*; D005260:Female; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000150:complications / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008875:Middle Aged; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D011014:Pneumonia / Q000201:enzymology / Q000209:etiology; D012202:Reye Syndrome / Q000209:etiology*
D009954:Ornithine Carbamoyltransferase; D010770:Phosphotransferases; D002222:Carbamoyl-Phosphate Synthase (Ammonia)