[The effect of ethymizole on the concentration of cyclic 3',5'-adenosine monophosphate in brain tissue].
It was found by the enzymatic method of cAMP determination that aethymizol (25 mg/kg) caused a more than double increase in cAMP in the rat brain tissue 20 minutes after the intraperitoneal injection. Changes in carbohydrate metabolism in the brain typical of cAMP increased, i.e. reduction in glycogen and an increase in glucose were revealed. The mechanism of aethymizol action was apparently connected with an increase in cAMP formation in the brain tissue.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D000242:Cyclic AMP / Q000032:analysis*; D005042:Etimizol / Q000494:pharmacology*; D005947:Glucose / Q000032:analysis; D006003:Glycogen / Q000032:analysis; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical
D007093:Imidazoles; D006003:Glycogen; D000242:Cyclic AMP; D005947:Glucose; D005042:Etimizol
Vliianie étimizola na soderzhanie tsiklicheskogo 3',5'-adenozinmonofosfata v tkani mozga