Nerve elements of the heart in aorto-coronary by-pass conditions.
Experiments were conducted on 100 dogs with creation of autovenous aortocoronary shunts in the coronary artery. The hearts were examined 1 year following surgery by routine histological, neurohistological, histochemical and electron-microscopic techniques. No severe destructive changes were revealed in the shunting system. The main process develop in the heart very early following surgery and consist in reactive changes in the intramural nerve elements, elevation of the phosphatase activity in the walls of the microcirculatory bed, redistribution of acid and neutral mucopolysaccharides and changes of permeability of the haematohistiocytic barriers; they are an adaptation response of the myocardium to operative stress and new conditions of influx of blood to the cardiac muscle.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004285:Dogs; D006025:Glycosaminoglycans / Q000378:metabolism; D006321:Heart / Q000294:innervation*; D008833:Microcirculation / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009412:Nerve Fibers / Q000201:enzymology / Q000473:pathology; D009474:Neurons / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
D006025:Glycosaminoglycans; D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases