title: Snythesis and antiprotozoal activity of nitro derivatives of 2, 2'-biimidazole.
abstract: We synthesized a series of 2,2'-biimidazoles with different substituents and screened them against Entamoeba histolytica, Trichomonas vaginalis and Giardia muris. A 5-nitro group is necessary for the inclusion of activity and an amino group exercises favourable effect on in vivi activity.
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004748:Entamoeba histolytica / Q000187:drug effects; D004749:Entamoebiasis / Q000188:drug therapy; D005260:Female; D005873:Giardiasis / Q000188:drug therapy; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D051379:Mice; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D007093:Imidazoles; D009593:Nitroimidazoles