The effect of antiestrogens on egg yolk protein synthesis and estrogen-binding to chromatin in the rooster liver.
Nafoxidine and CI-628, two well known antiestrogenic compounds, reduce the stimulating effect of estradiol on the estrogen-binding capacity of the liver chromatin from roosters. In vitro both antiestrogens compete with [3H]estradiol for the binding sites on the liver chromatin. They inhibit the estrogen-induced synthesis of egg yolk proteins (vitellogenin) and fail to induce this estrogen-specific protein synthesis by themselves. They show the ability, however, to increase the estrogen-binding sites on the liver chromatin to some extent.
D000818:Animals; D002645:Chickens; D002843:Chromatin / Q000187:drug effects / Q000494:pharmacology*; D004527:Egg Proteins / Q000096:biosynthesis*; D004530:Egg Yolk; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009594:Nitromifene / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D011956:Receptors, Cell Surface
D002843:Chromatin; D004527:Egg Proteins; D004965:Estrogen Antagonists; D011759:Pyrrolidines; D011956:Receptors, Cell Surface; D004958:Estradiol; D009594:Nitromifene