title: Apolipoprotein of the low density lipoprotein of human plasma: structural study in familial hyperbetalipoproteinemia.
abstract: Isolation of the low density lipoprotein (LDL) from human plasma was accomplished within a narrow density interval (1.030-1.045 g/ml). After covalent modification by maleic anhydride of the protein moiety and delipidation it was possible to fractionate, by ion-exchange chromatography, up to 35% of the protein into three peptides with distinctive amino acid compositions. These fractions appeared to be identical in normal individuals and in patients with familial hyperbetalipoproteinemia (FH). Our findings provide further evidence that in FH the abnormal catabolism of the protein moiety of LDL is not related to a modification of its structure.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001059:Apoproteins / Q000097:blood* / Q000302:isolation & purification; D002648:Child; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged
chemical_list: D000596:Amino Acids; D001059:Apoproteins; D008077:Lipoproteins, LDL