Biphasic effect of testosterone propionate on Sertoli cell secretory function.
When various doses of testosterone propionate (10 to 10,000 mug/day) were given to 21-day-old rats for 10 days a biphasic effect was seen both on testis weight and production of androgen-binding protein (ABP). At low doses (10 to 100 mug testosterone propionate/day) there was a reduction in testis weight as well as ABP content in the epididymis. At higher doses of testosterone propionate, there was a stimulation of both testicular weight and ABP production in spite of suppressed serum FSH and LH levels. These effects of testosterone propionate on Sertoli cell secretory function strongly suggest that the Sertoli cell is a target cell for androgen.
D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D011485:Protein Binding; D014176:Protein Biosynthesis; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D012708:Sertoli Cells / Q000187:drug effects / Q000378:metabolism*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
D011956:Receptors, Cell Surface; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone