Adrenaline, noradrenaline, and adenosine 3',5'-monophosphate levels in plasma of healthy persons during ergometric work with and without beta-receptor blocking agents.
After endogeneous increase of noradrenaline and adrenaline during a submaximal exercise test, plasma levels of adenosine 3',5'-monophosphate (cyclic AMP) show no significant change. After effective beta-receptor blockade due to propranolol plasma levels of cyclie AMP do not change significantly, either during rest or during exericse. After effective beta-receptor blockade due to propranolol the plasma levels of noradrenaline and adrenaline, reached during exercise, are significantly reduced compared with the plasma catecholamine levels obtained under the same exercise conditions wtihout beta-blockade. In contrast to the findings of other investigators, increased plasma catecholamine levels after administration of propranolol could not be observed.
D001794:Blood Pressure / Q000187:drug effects; D000242:Cyclic AMP / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D006321:Heart / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009638:Norepinephrine / Q000097:blood*; D005082:Physical Exertion / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*
D011433:Propranolol; D000242:Cyclic AMP; D009638:Norepinephrine; D004837:Epinephrine