Toxicity and metabolism of methyl n-butyl ketone.
MEK (2-butanone) when combined with MBK (2-hexanone) markedly enhanced MBK neurotoxicity. MBK in rat plasma after exposure to MBK/MEK increased with time. Metabolites of MBK identified in blood and urine of rats and guinea pigs were 2-hexanol and 2,5-hexanedione.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D002074:Butanones / Q000633:toxicity; D002849:Chromatography, Gas; D004781:Environmental Exposure; D005243:Feces / Q000032:analysis; D006168:Guinea Pigs; D000441:Hexanols / Q000097:blood / Q000652:urine; D006588:Hexanones / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000633:toxicity* / Q000652:urine; D007659:Ketones / Q000633:toxicity*; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012119:Respiration; D013997:Time Factors
D002074:Butanones; D000441:Hexanols; D006588:Hexanones; D007659:Ketones; D010634:Phenobarbital