The effects of adenine nucleotides and guanine nucleotides on urate synthesis de novo by isolated chick liver and kidney cells.
Isolated chick liver and kidney cells produce urate de novo from glycine, and this is partially inhibited by 1 mm-AMP and by 1 mm-GMP in liver cells but not in kidney cells. Azaserine fully inhibits this synthesis de novo, but attempts to isolate formylglycine amide ribonucleotide from azaserine-blocked cells were unsuccessful.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D001377:Azaserine / Q000494:pharmacology; D002645:Chickens; D006152:Cyclic GMP / Q000494:pharmacology; D005998:Glycine / Q000032:analysis / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D012267:Ribosemonophosphates / Q000032:analysis; D014527:Uric Acid / Q000096:biosynthesis*
D012267:Ribosemonophosphates; D014527:Uric Acid; D000249:Adenosine Monophosphate; D001377:Azaserine; D006152:Cyclic GMP; D005998:Glycine