title: A longitudinal study of very low-birthweight infants. II: Results of controlled trial of intensive care and incidence of handicaps.
abstract: Between 1966 and 1970, infants with birthweights between 1000 and 1500g entered a randomized controlled trial to determine the short-term and long-term results of neonatal intensive care. Of 158 long-term survivors, five were lost to follow-up, but the multidisciplinary research team prospectively followed 143 children up to the age of eight years. Useful data were available for the other 10 children. Of the long-term survivors 74 had received routine, and 84 had received intensive nursery care. At eight years of age there were no statistically significant differences in the frequencies of a variety of individual abnormalities; fewer of the intensively managed children had cerebral palsy, but sensorineural deafness and ocular abnormalities occurred more frequently. Individual children were graded into four carefully defined groups: (a) profound handicap (4.4 per cent of entire study group); (b) severe handicap (10.1 per cent); (c) significant handicap (37.3 per cent); and (d) trivial or no handicap (41.8 per cent). Inadequate data were available for 6.3 per cent of the children. It was apparent that the improved survival attributed to intensive neonatal care was achieved at the expense of additional severely handicapped children, and this feature is discussed.
mesh_terms: D002547:Cerebral Palsy / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003422:Critical Care; D006233:Persons with Disabilities; D004410:Dyslexia / Q000517:prevention & control; D005128:Eye Diseases / Q000517:prevention & control; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008607:Intellectual Disability / Q000517:prevention & control; D008137:Longitudinal Studies; D011181:Postnatal Care; D011897:Random Allocation