Some aspects of ACTH action on cerebral metabolism in infant rats.
In 150 newborn rats of either sex the influence of ACTH on cerebral phospholipid, phosphoprotein, and nucleic acids metabolism was investigated. The results show that ACTH induces a great stimulation of the cerebral phospholipid metabolism, especially in 14-and 21-day-old rats, a significant increase in the phosphoprotein metabolism at 7 and 14 days after birth, and a stimulation of the RNA synthesis in 7- and 14-day-old rats. The significance of these results is discussed.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D010743:Phospholipids; D010750:Phosphoproteins; D012313:RNA; D000324:Adrenocorticotropic Hormone; D004247:DNA