title: [Tricyclic homologs of piperazine. III. Synthesis of 4-substituted hexahydro-1H-2,6-methanopyrrolo[1,2a]pyrazines].
abstract: The Authors describe the synthesis of some quaternary salts of the hexahydro-1H-2,6-methanopyrrolo[1,2-a]pyrazines mono or disubstituted at carbon-4. These were obtained directly by cyclization of the corresponding diazabicyclooctanes, by formation of a substituted ethylenic bridge between the two nitrogen atoms. The compounds were pharmacologically screened; the hypothesis of enhancement of curare-like activity in comparison with the unsubstituted derivatives was not confirmed.
mesh_terms: D000818:Animals; D003500:Cyclization; D066298:In Vitro Techniques; D008722:Methods; D009119:Muscle Contraction / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000138:chemical synthesis; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D011719:Pyrazines
vernacular_title: Omologhi triciclici della piperazina. Nota III (1)--Sintesi di esaidro-1H-2,6-metanopirrolo[1,2-a]pirazine 4-sostituite.