[Chronic ethanol intoxication in mice by the pulmonary route. Its use in the study of tryptophan penetration into the brain].
Pulmonary ethanol absorption produces homogeneous intoxicated mices within a week. Intoxication is evidenced in the increase of plasmatic, hepatic and cerebral gamma-glutamyl-transferases. An increase of blood-brain-barrier permeability for tryptophan is not observed as in acute intoxication.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D012119:Respiration; D012712:Serum Globulins / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*
D012712:Serum Globulins; D000431:Ethanol; D014364:Tryptophan
L'intoxication éthylique chronique de la Souris par voie pulmonaire. Son utilisation dans l'étude de la pénétration du tryptophanne dans le cerveau.