title: [Properties of protamine-heparin complexes].
abstract: Protamine-heparin complexes have a considerable resistance to physical factors of the environment such as a high ion strength and acid or alkaline pH. Free protamine is digested by plasmin giving products with a greatly decreased ability to form complexes with heparin and lower antiheparin action. Bound protamine, on the other hand, is resistant to the action of plasmin as a result of which the enzyme does not release heparin from the complexes.
mesh_terms: D005341:Fibrinolysin / Q000378:metabolism; D006493:Heparin / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D011479:Protamines / Q000378:metabolism*
chemical_list: D011479:Protamines; D006493:Heparin; D005341:Fibrinolysin
vernacular_title: Właściwości kompleksów protamina-heparyna.