[Host-leukemogenic virus relation: genetic control of the appearance of leukemia].
A complex genetic system controls the susceptibility to virus induced leukemia. A good example is provided by AKR mice in which several genes acting in association are involved. The control is demonstrable at several levels: a) virus expression, b) virus replication, c) antitumor immune response. In addition one or two other genes could be involved. The "Leukemia-permissive" genotype would be probably rarely present and the AKR provides the model of a mice in which all genetic locus bear the permissive alleles.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D004279:DNA, Viral; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D009154:Mutation; D012190:Retroviridae / Q000302:isolation & purification; D014779:Virus Replication
D004279:DNA, Viral
Relations hôte-virus leucémogènes: contrôle génétique de l'apparition de la leucémie