[Inhibition of the growth of spontaneous mammary gland tumors in mice by acetylated corticotropin].
As a result of chronic administration of acetylated corticotropin (anahormone), a decrease in the incidence of spontaneous mammary tumors in C3H/He mice has been noted. An administration of anahormone after a surgical removal of tumor either pre-or postoperatively) prolonged the free period in the development of recurrences and improved the survival rate of operated mice. It is presumed that inhibition of the tumor process by an anahormone is related with its suppressive action on the adrenal function and activity of the ovarian-gonadotropin system.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains
D000324:Adrenocorticotropic Hormone
Tormozhenie razvitiia spontannykh opukholeĭ molochnoĭ zhelezy u mysheĭ atsetilirovannym kortikotropinom