Cellular cooperation in transformation by EB virus.
Human lymphoid cells transformed by Epstein-Barr (EB) virus are thought to be B-lymphocytes. Transformation of human mononuclear leukocytes by Epstein-Barr virus was decreased or lost by removing adhering or nonadhering mononuclear cells from the mixtures of peripheral blood leukocytes but was not decreased by removing T-lymphocytes. Recombining adherent and nonadherent mononuclear cells without T-lymphocytes restored transformability, but conditioned medium from cultures of adherent cells did not. Cooperation between non-adherent (B-cells) and adherent cells (monocytes) is necessary for EB virus transformation.
D000328:Adult; D000818:Animals; D001769:Blood; D003588:Cytopathogenic Effect, Viral; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007962:Leukocytes / Q000276:immunology; D013601:T-Lymphocytes; D014470:Umbilical Cord