Hepatic prolyl hydroxylase activity in experimental cirrhosis.
Hepatic collagen synthesis was studied during progressive fibrosis induced by carbon tetrachloride in male Sprague-Dawley rats by determination of prolyl hydroxylase activity and hydrocyproline levels along with morphological assessment of fibrosis. Cirrhosis was present after approximately 4 weeks treatment. Prolyl hydroxylase activity was increased significantly before fibrosis was apparent histologically or by hydroxyproline levels. The significance of this finding is discussed.
D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D003067:Coenzymes; D003094:Collagen / Q000096:biosynthesis; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital; D011092:Polyethylene Glycols; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D013997:Time Factors
D003067:Coenzymes; D011092:Polyethylene Glycols; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline; D010634:Phenobarbital