Histiocytosis X. IV--Immunologic response assessed by lymphocyte transformation tests.
Eight children with histiocytosis X were investigated with reference to immunologic reactivity in vitro (PHA, PWM, Con-A and MLC testing). No significant impairment of immune function was detected, but a subnormal (statistically insignificant) response in the MLC test may suggest some abnormality of the T lymphocytes reacting against allogeneic cells. In a patient who relapsed a marked, but insignificant, increase in lymphocyte reactivity in vitro was observed.
D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A / Q000494:pharmacology; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A