Effect of hypoglycemia on extracellular levels of cyclic AMP in man.
This study was designed to assess the response of cyclic AMP to "endogenous" hormonal stimulation resulting from insulin-induced hypoglycemia. Insulin was administered to four normal subjects and four adrenalectomized patients. Hypoglycemia resulted in four-fold increases in plasma cyclic AMP. This response is thought to be secondary to beta-adrenergic stimulation for the following reasons: (1) the response was absent in adrenalectomized, cortisol-treated subjects; (2) it was abolished by propranolol; and (3) urinary excretion of cyclic AMP did not reflect the rise in plasma cyclic AMP.
D000311:Adrenal Glands / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D005110:Extracellular Space; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism*; D007328:Insulin; D011433:Propranolol; D011941:Receptors, Adrenergic / Q000187:drug effects; D013268:Stimulation, Chemical
D007328:Insulin; D011941:Receptors, Adrenergic; D011433:Propranolol; D000242:Cyclic AMP; D004837:Epinephrine