Collagenase production by lymphokine-activated macrophages.
Macrophages incubated with products (lymphokines) secreted by stimulated spleen cells produced collagenase. Active lymphokines were obtained both from mitogen- and antigen-stimulated lymphocytes. These observations suggest that the degradation of collagen in chronic inflammatory lesions may be caused by macrophage collagenase.
D000818:Animals; D000941:Antigens; D003208:Concanavalin A; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000494:pharmacology*; D008264:Macrophages / Q000201:enzymology* / Q000276:immunology; D003012:Microbial Collagenase / Q000096:biosynthesis*; D009578:Nitrobenzenes; D010047:Ovalbumin / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014373:Tuberculin
D000941:Antigens; D008222:Lymphokines; D009578:Nitrobenzenes; D014373:Tuberculin; D003208:Concanavalin A; D012710:Serum Albumin, Bovine; D010047:Ovalbumin; D003012:Microbial Collagenase