Protective effect of modified silica gel fraction (MSGF) on the storage of canine liver for transplantation.
MSGF protects the function of canine ischemic (20mins) liver stored for 14 hrs. No significant liver protection, from irreversible damage, in dogs transplanted with ischemic livers, flushed with Ringer's lactate, Collins' solution, Sacks' solution or SGF before hypothermic storage was noted. Sacks' solution, although consistently better than Ringer's lactate and similiar to Collins' solution and SGF, was not half as good as MSGF.
D000418:Albumins / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D003080:Cold Temperature; D004285:Dogs; D004798:Enzymes / Q000097:blood; D005260:Female; D005782:Gels / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D012822:Silicon Dioxide / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D014021:Tissue Preservation; D014184:Transplantation, Homologous / Q000401:mortality
D000418:Albumins; D001639:Bicarbonates; D004798:Enzymes; D005782:Gels; D008353:Mannitol; D012965:Sodium Chloride; D011343:Procaine; D012822:Silicon Dioxide; D006493:Heparin; D005947:Glucose; D011188:Potassium