Quantum chemical study of relative reactivities of a series of amines and nitriles: relevance to prebiotic chemistry.
Using the Iterative Extended Hucken Theory (IEHT) calculations of the elctron distribution and orbital energies of a series of thirteen amines, nitriles and amino-nitriles relevant to prebiotic and cosmo-chemistry have been carried out. Ground state properties such as the energy and nature of the highest occupied (HOMO) and lowest empty (LEMO) molecular orbitals, net atomic charges and number of non-bonding electrons have been identified as criteria for correlating the relative nucleophilicity of amine and nitrile nitrogens and the electrophilicity of nitrile and other unsaturated carbon atoms. The results of such correlations can be partially verified by known chemical behavior of these compounds and are used to predict and understand their role in prebiotic organic synthesis.
D000588:Amines / Q000138:chemical synthesis; D000607:Aminoacetonitrile; D000629:Aminopropionitrile; D000641:Ammonia; D055598:Chemical Phenomena; D002621:Chemistry; D006856:Hydrogen Cyanide; D009570:Nitriles / Q000138:chemical synthesis; D011789:Quantum Theory
D000588:Amines; D009570:Nitriles; D000629:Aminopropionitrile; D006856:Hydrogen Cyanide; D000607:Aminoacetonitrile; D000641:Ammonia