Halothane action on lymphocytes does not involve cyclic AMP.
Both theophylline and halothane inhibited transformation of human lymphocytes by phytohemagglutinin (PHA). Theophylline did not augment the inhibitory action of halothane and depressed PHA transformation of halothane-treated cells to the same extent as that of air-treated cells. Halothane- and air-treated lymphocytes, prior to PHA addition, had the same content of cyclic AMP. The addition of PHA to these cultures raised cyclic-AMP concentrations to the same extent in halothane- and air-treated lymphocytes. Halothane action on PHA-stimulated lymphocytes appears not to involve changes in cyclic nucleotide metabolism.
D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013806:Theophylline / Q000008:administration & dosage / Q000494:pharmacology
D037102:Lectins; D013806:Theophylline; D000242:Cyclic AMP; D006221:Halothane