[Formation and persistence of latex-agglutination-inhibiting IgG- and IgM-antibodies in rabbits inoculated with poliomyelitis, Coxsackie and encephalomyocarditis viruses (author's transl)].
The formation and presistence of virus specific IgG- and IgM-antibodies produced in rabbits after a single dose of poliomyelitisvirus, coxsackievirus or encephalomyocarditisvirus were tested comparatively by latex-agglutination-inhibition test, hemagglutination-inhibition test and neutralization test. The animals were immunized either intravenously alone or with Freund's complete adjuvant. The IgM-antibodies were only detectable for a short time by the three tests. In the IgG-fraction and in the unfractionated serum the neutralizing antibodies persisted without any loss in titer during the period observed, whereas the latex-agglutination-inhibiting and hemagglutination-inhibiting antibodies showed a significant decrease. The hemagglutination-inhibiting antibodies required 23 weeks (Figure 5), the latex-agglutination-inhibiting antibodies 7 weeks (without Freund's complete adjuvant; Figure 1 and 3) or about 16 weeks (with Freund's complete adjuvant; Figure 2, 4 and 5) respectively to decline to 25% of their maximum titer.
D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D000918:Antibody Specificity; D004686:Encephalomyocarditis virus / Q000276:immunology*; D004770:Enterovirus / Q000276:immunology*; D005620:Freund's Adjuvant; D006385:Hemagglutination Inhibition Tests; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007841:Latex Fixation Tests; D009500:Neutralization Tests; D017955:Poliovirus / Q000276:immunology*; D011817:Rabbits
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005620:Freund's Adjuvant
Die Bildung und Persistenz latexagglutinationshemmender IgG- und IgM-Antikörper im Kaninchen nach Applikation von Poliomyelitis-, Coxsackie- und Enzephalomyokarditisviren