title: Effect of pentagastrin, histalog, glucagon, secretin, and perchlorate on the gastric handling of 99mTc pertechnetate in mice.
abstract: Pentagastrin, histalog, glucagon, secretin, and perchlorate were intravenously injected into mice in order to investigate the hormonal regulation of 99mTc pertechnetate uptake by gastric mucosa. Pentagastrin significantly increased uptake; the effect of histalog was weaker. Secretin did not alter the uptake. Glucagon produced some diminution, and perchlorate significantly inhibited gastric uptake. Hormones may play a role in improving the sensitivity and specificity of diagnostic tests for Meckel's diverticulum.
mesh_terms: D000818:Animals; D001625:Betazole / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology; D008297:Male; D051379:Mice; D010418:Pentagastrin / Q000494:pharmacology*; D010472:Perchlorates / Q000494:pharmacology; D012588:Scintillation Counting; D012633:Secretin / Q000494:pharmacology; D013667:Technetium / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D010472:Perchlorates; D012633:Secretin; D001625:Betazole; D013667:Technetium; D005934:Glucagon; D010418:Pentagastrin