Long-term results in 35 HLA-identical sibling and 3 HLA-identical parent-child renal allograft recipients.
35 recipients of a renal allograft from an HLA-identical sibling followed for 3 months to nearly 15 years have had 1- and 5-year allograft survivals of 93 and 76%, respectively, levels comparable to the 90 and 80% reported at 1 and 5 years for identical twins. Although high MLC stimulation was related to graft failure, intermediate degrees of stimulation were not. The most common cause of graft failure was chronic rejection (n=4) and of death, myocardial infarction (n=3). However, overall complications such as aseptic necrosis were distinctly lower than in mismatched recipients. 3 children received an allograft from an HLA-identical parent, possible because of a shared parental haplotype, and all have excellent function from 2 to nearly 9 years after transplantation.
D000293:Adolescent; D000328:Adult; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006238:Haploidy; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011247:Pregnancy; D014184:Transplantation, Homologous; D014430:Twins, Monozygotic