title: Paget's disease of the vulva and carcinoma of the breast.
abstract: Vulvar Paget's disease is an intraepithelial change which is locally recurrent and has minimal if any propensity to invasion. Its major significance lies in the frequency with which concomitant carcinomas are discovered in association with the vulvar skin lesion. Adenocarcinoma of the vulvar apocrine glands is the most commonly associated tumor. Another apocrine adenocarcinoma, carcinoma of the breast, either antecedent or concomitant, is the second most frequently associated tumor, having been noted in 14 cases of vulvar Paget's disease. A case report illustrating this association is presented, and the importance of preoperative breast screening procedures in all patients with vulvar Paget's disease is demonstrated.
mesh_terms: D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008408:Mastectomy; D010145:Paget Disease, Extramammary / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014846:Vulvar Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014986:Xeroradiography