[Mesentery capillary barrier in rats injected intravascularly with ascitic Zajdela hepatoma. III. Effect of serotonin and histamine on the extravasation of the tumor].
The addition of serotonin or of histamin with tumoral cells of ascitic Zajdela's hepatoma and their injection in aorta induce plain hemodynamic changes and increase the tumoral extravasation. So only cells blocked in thrombi are observed in blood vessels. Therefore, serotonin and histamin do facilitate tumoral cells extravasation, allowing so a better metastatic diffusion in this experimental pattern.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D006528:Carcinoma, Hepatocellular; D006632:Histamine / Q000494:pharmacology*; D008113:Liver Neoplasms; D008643:Mesentery / Q000098:blood supply; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental; D009360:Neoplastic Cells, Circulating; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D006632:Histamine
La barrière capillaire du mésentère de rat ayant reçu une injection intravasculaire d'hépatome ascitique de Zajdela. III. Influence de la sérotonine et de l'histamine sur l'extravasation tumorale