[Liver damage caused by laxatives. A contribution to the hepatotoxicity of 4,4'-(2-quinolylmethylene)-diphenol-hydrochloride].
A female patient developed a recurrent hepatitis-like liver damage after ingestion of a laxative containing 4,4'-(2-quinolyl-methylene)-diphenol-hydrochloride. After cessation of the drug the clinical picture improved. The hyperbilirubinemia decreased and the definitely elevated GOT, GPT, alkaline phosphatase and gamma-GTP became normal. Histologically hepato-cellular damage was seen with intra-hepatic cholestasis. As a cause for these symptoms, resembling those after taking oxyphenisatin-containing preparations, immunological procedures were thought responsible, such as "unpredictable hepatic drug reactions".
D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002400:Cathartics / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced; D003085:Colic / Q000139:chemically induced; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced; D007211:Indoles / Q000009:adverse effects; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced; D008875:Middle Aged; D010636:Phenols / Q000009:adverse effects*; D010744:Phosphoric Monoester Hydrolases / Q000097:blood; D011804:Quinolines / Q000009:adverse effects; D013997:Time Factors; D000637:Transaminases / Q000097:blood
D002400:Cathartics; D007211:Indoles; D010636:Phenols; D011804:Quinolines; D000637:Transaminases; D000469:Alkaline Phosphatase; D010744:Phosphoric Monoester Hydrolases; D001663:Bilirubin
Leberschädigung durch Laxantien. Ein Beitrag zur Hepatotoxizität von 4,4'-(2-Chinolyl-methylen)-diphenolhydrochlorid