title: Primary liver cancer associated with long-term oestrogen therapy.
abstract: A woman with primary liver cancer after nine years therapy with polyestradiol-phosphate is reported. The oestrogen was administered monthy by intramuscular injection for menopausal symptoms. This case suggests a possible association between long-term oestrogen therapy and the development of hepatic malignancy and also must direct attention to both hormone components in the evaluation of tumour development in users or oral contraceptives.
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D045166:Estradiol Congeners / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged
chemical_list: D045166:Estradiol Congeners