Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis.
A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.
D002471:Cell Transformation, Neoplastic; D003673:Defective Viruses; D006378:Helper Viruses; D007938:Leukemia / Q000209:etiology; D008954:Models, Biological; D008979:Moloney murine leukemia virus / Q000032:analysis / Q000378:metabolism; D012367:RNA, Viral / Q000032:analysis* / Q000378:metabolism; D012190:Retroviridae; D014779:Virus Replication
D012367:RNA, Viral