Restoration of diminished splenic responses to phytohemagglutinin and concanavalin A in adjuvant-induced disease by virazole: possible pathogenetic role of a virus and suppressor cells.
Adjuvant arthritis is inhibited by the interferon-inducing anti-viral agents statolon, pyran copolymer and tilorone, and by the passive transfer of interferon. The present experiments demonstrate that Virazole, a non-interferon-inducing, anti-viral agent also inhibits adjuvant arthritis. The responses of splenic lymphocytes to phytohemagglutinin and concanavalin A are diminished in active adjuvant disease, due to suppressor cells. Suppressor cells are absent during spontaneous, methodrexate or corticosteroid-induced remissions. Suppressor cells are also absent during Virazole-induced inhibition of adjuvant disease. Methotrexate and corticosteroids inhibit suppressor cells in preference to mitogen-responsive cells in vitro. The preferential inhibition with Virazole is superior to that noted with methotrexate or corticosteroids.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D005898:Glass; D006854:Hydrocortisone / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology*; D010969:Plastics; D051381:Rats; D011919:Rats, Inbred Strains; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014775:Virus Activation
D010835:Phytohemagglutinins; D010969:Plastics; D012263:Ribonucleosides; D003208:Concanavalin A; D012254:Ribavirin; D006854:Hydrocortisone; D008727:Methotrexate