Ectopic adrenocorticotrophic hormone production and neoplasm.
Three patients presented with severe hypokalaemic, hypochloraemic alkalosis, muscle weakness and later cutaneoud pigmentation.  There were few signs of Cushing's syndrome.  Two had bronchial and one pancreatic neoplasm.  Plasma cortisol and urinary steroid metabolites were extremely elevated and synacthen stimulation showed significant adrenal capacity even with adrenal metastases.  Aminoglutethamide reduced plasma cortisol in two patients.
D000324:Adrenocorticotropic Hormone; D000328:Adult; D000616:Aminoglutethimide / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000150:complications; D002245:Carbon Dioxide / Q000097:blood; D002277:Carcinoma / Q000150:complications; D018288:Carcinoma, Small Cell / Q000150:complications; D006729:Hormones, Ectopic; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D011188:Potassium / Q000097:blood
D006729:Hormones, Ectopic; D000616:Aminoglutethimide; D002245:Carbon Dioxide; D000324:Adrenocorticotropic Hormone; D011188:Potassium; D006854:Hydrocortisone