title: [Primary liver carcinogenesis induced by the pesticide 2-(4-tert-butylphenoxy0-1-methylethyl 2-chloroethyl sulphite (Aramite)].
abstract: Wistar rats were fed, during 56 weeks, a diet containing 5 g/kg of Aramite. At the end of the treatment, all the surviving animals show, on anatomo-pathological examination, malignant proliferation of the hepatic tissue and, in certain cases, of biliary ducts. This compound, proposed in the past as acaricide in agriculture, can thus be considered as a model substance for induction of malignant liver tumors.
mesh_terms: D002759:Adenoma, Bile Duct / Q000139:chemically induced* / Q000473:pathology; D000476:Alkanesulfonates / Q000633:toxicity; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D007306:Insecticides / Q000633:toxicity*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats
chemical_list: D000476:Alkanesulfonates; D007306:Insecticides
vernacular_title: Cancérogenèse hépatique primitive chez le rat sous l'influence d'un composé pesticide, le sulfite de chloro-2-éthyle et de (p-tert-butyl phénoxy) 2-méthyl 1 éthyle (Aramite)