[Mechanism of hyocorticosteronemia action of Strongyloides ratti in the rat].
In order to explain the hypocorticosteronemia which establishes itself in rats with Strongyloides ratti parasites, we are proceeding with a functional exploration of the hypothalamo-hypophyso-corticosurrenal axis in experimentally infested rodents. The adreno-cortico-tropic-hormone test (A.C.T.H.), stress to ether and the Lysin-8-Vasopressin and Metopirone tests lead to concordant results: -- the hypothalamo-pituitary-corticosurrenal present a functional integrity which allows it to react normally to direct stimulation or to feed-back; -- the deficiency seems to relate to the hypothalamic secretion of the cortico-releasing factor; -- the cause would stem from an inhibition of the nervous mechanism which regulates this neurosecretion.
D000305:Adrenal Cortex Hormones; D000309:Adrenal Insufficiency / Q000469:parasitology*; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003346:Corticotropin-Releasing Hormone; D004987:Ethers / Q000008:administration & dosage; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008236:Lypressin / Q000008:administration & dosage; D008297:Male; D008797:Metyrapone / Q000008:administration & dosage; D009433:Neural Inhibition / Q000187:drug effects; D009489:Neurosecretion; D009490:Neurosecretory Systems / Q000503:physiopathology; D010270:Parasite Egg Count; D010906:Pituitary Hormone-Releasing Hormones; D010912:Pituitary-Adrenal Function Tests; D051381:Rats; D013321:Strongyloides / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000097:blood* / Q000469:parasitology; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D004987:Ethers; D010906:Pituitary Hormone-Releasing Hormones; D008236:Lypressin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone; D008797:Metyrapone
Mécanisme de l'action hypocorticostéronémiante de Strongyloides ratti chez le rat