Blastomogenic activity of p-hydroxyphenyllactic acid in mice.
Blastomogenic activity of p-hydroxyphenyllactic acid was established by prolonged s.c. administration into C57BL/6 and CC57BR mice. Phenyllactic acid was also tested and was not blastomogenic under the same conditions. The preparations in aqueous solutions were injected into the dorsal region twice weekly in 1.5-mg doses. The total dose per mouse was 42 mg p-hydroxyphenyllactic acid or 50 mg phenyllactic acid. The resorptive character and many forms of blastomogenic activity of p-hydroxphenyllactic acid were shown. It induced neoplasms of varied histogenesis (leukemias, adenomas, hepatomas, and tumors of the vascular tissue),including benign and malignant tumors and precancerous conditions of the urniary bladder.
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D007942:Leukemia, Experimental / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010648:Phenylacetates; D011230:Precancerous Conditions / Q000139:chemically induced; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D010648:Phenylacetates