title: [Studies to the in-vitro-effectiveness of Spectacillin (author's transl)].
abstract: In this study the sensibility of important disease germs of a clinical and an ambulatory test material has been investigated to the substances "Epicillin" and "Ampicillin". Thereby could be found that 67% (43%) of the E. coli and 55% (36%) of the proteus type, as well as 96% (96%) of the enterococcus type of the ambulatory (clinical) test material were sensitive to Epicillin and Ampicillin. Staphylococcus not producing penicillinase, were well-sensitive, while staphylococcus producing penicillinase, contrarily showed to be insensitive. Salmonellae proved to be well-sensitive up to 97%, and the rest left was limited sensitive. The minimal inhibitory concentration (MIC) resulted in favourable findings for enterococcus, staphylococcus aureus and salmonellae; at a corresponding sensibility the same is valid for E. coli and the proteus. The investigations carried out in-vitro, reveal an equal effectiveness of Epicillin and Ampicillin.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D011511:Proteus / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014556:Urine / Q000382:microbiology
chemical_list: D000667:Ampicillin; D010397:Penicillanic Acid
vernacular_title: Untersuchungen zur In-vitro-Wirkung von Spectacillin  (Epicillin)