Gastrinoma of duodenal G-cell origin.
A 65-year-old man with hypergastrinemia associated with the Zollinger-Ellison syndrome was found to have a duodenal "carcinoid-islet cell tumor." Gastrin levels have remained normal for more than 1 year following total gastrectomy and removal of the duodenal tumor. Immunohistochemical studies for gastrin localization revealed positive staining of the tumor and of a population of nonneoplastic G-cells in the adjacent duodenal mucosa and Brunner's glands. These results support the hypothesis that gastrinomas may arise as primary tumors from duodenal G-cells rather than from ectopic pancreatic tissue. "Carcinoidislet cell tumors," like other tumors of APUD-cell origin, may express dual biochemical functions in the form of polypeptide hormone and/or amine secretion. Their content of specific hormonal products may be predicted on the basis of sensitive histochemical and immunohistochemical techniques.
D007516:Adenoma, Islet Cell / Q000097:blood / Q000473:pathology*; D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology*; D004379:Duodenal Neoplasms / Q000097:blood / Q000473:pathology*; D005755:Gastrins / Q000097:blood; D006801:Humans; D008297:Male; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000150:complications
D005755:Gastrins