The influence of fluphenazine on the interaction of noradrenaline and serotonin.
The neurotransmitter catecholamines control metabolism 5-HT in pineal gland by stimulating pineal serotonin-N-acetyltransferase (EC 2.3.1.5) activity [1, 2]. To prove the influence of FP on the metabolism 5-HT provoked by norepinephrine was tested. Rat pineal gland were incubated in media containing 5-HT- 14C or 5-HT- 14C and FP (1-10(-6)-1-10(-4) M). Norepinephrine (1-10(-6)-1-10(-4)M) was added at the start of the experiment. The level of cyclic 3',5'-AMP, activity of HIOMT and metabolites of 5-HT-14C was examined. The results have suggested that the FP inhibit the provoked by norepinephrine metabolism of 5-HT in the rat pineal gland by decrease the formation of c-3',5'-AMP.
D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004347:Drug Interactions; D005476:Fluphenazine / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000096:biosynthesis; D009638:Norepinephrine / Q000494:pharmacology*; D010870:Pineal Gland / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical
D012701:Serotonin; D000242:Cyclic AMP; D000121:Acetylserotonin O-Methyltransferase; D008550:Melatonin; D005476:Fluphenazine; D009638:Norepinephrine