Malignant optic glioma in a 70-year-old patient.
In a 70-year-old man with glioma of the optic nerves and tracts, the initial symptom was a unilateral loss of vision that progressed rapidly and was followed by amaurosis of both eyes. All diagnostic radiological procedures were negative. Four months after the onset of the disease, the patient developed hemiplegia, became comatose, and died. Post-mortem examination revealed a glioblastoma multiforme of both optic nerves, chiasma, and optic tracts that extended posteriorly into the left thalamus and medial geniculate body. The tumoral thickening of the optic nerves was absent in the intracanalicular part, a finding that concurred with the normal radiological appearance of the optic foramen. Glioblastoma multiforme of the optic pathways should be included in the differential diagnosis of acute visual failure in elderly people, even though the final diagnosis may be possible only at postmortem examination.
D000368:Aged; D001253:Astrocytes / Q000648:ultrastructure; D001766:Blindness / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology; D003951:Diagnostic Errors; D005134:Eye Neoplasms / Q000473:pathology*; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D008297:Male; D009336:Necrosis; D009362:Neoplasm Metastasis; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D009901:Optic Nerve Diseases / Q000473:pathology*