[Effect of catecholaminergic substances on the proconvulsive properties of the caudate nucleus].
In the freely moving rats stimulants of catecholaminergic tramission (DOPA, apomorphine, d,1-amphetamine, and also their combination with disulfiram) reduced the proconvulsive properties of the caudate nucleus. Under the effect of these substances there occurred a shortening of the cortical electroencephalographic response to a single stimulation of the nucleus in the animals given subconvulsive doses of pentaxylenetetrazol and a reduction of the extent of the spike-wave rhythm induced by the repeated caudate stimuli. On the contrary, inhibitors of catecholaminergic transmission (chlorpromazine, haloperidol, alpha-methyltyrosine and disulfiram) intensified the proconvulsive effect of the caudate nucleus.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002421:Caudate Nucleus / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D051381:Rats; D012640:Seizures / Q000139:chemically induced*; D013566:Sympathomimetics / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D008781:Methyltyrosines; D013566:Sympathomimetics; D007980:Levodopa; D006220:Haloperidol; D001058:Apomorphine; D004221:Disulfiram; D002746:Chlorpromazine
Vliianie katekholaminergicheskikh sredstv na prokonvul'sivnye svoĭstva khvostatogo iadra