Effect of progesterone on the in vivo binding of estrogens by uterine cells.
Progesterone selectively inhibits estradiol uptake by the nuclei of the luminal epithelial cells but not by other uterine cells. This inhibition in estrogen binding parallels the inhibition by progesterone of some estrogenic responses in the luminal epithelial cells only.
D000818:Animals; D001667:Binding, Competitive; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D004971:Estrus; D005260:Female; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D014599:Uterus / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure
D011956:Receptors, Cell Surface; D011374:Progesterone; D004958:Estradiol