On the mineralocorticoid and hypertensogenic properties of 16beta-hydroxy-dehydroepiandrosterone.
Dosages of either 1 or 2 mg daily of 16beta-hydroxy-dehydroepiandrosterone, given to mononephrectomized, salt-loaded female rats, had no detectable effect upon saline consumption, blood pressure, kallikrein excretion or heart and kidney weight. Its alleged mineralocorticoid properties, as judged by these criteria, were not demonstrable.
D000738:Androsterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007610:Kallikreins / Q000652:urine*; D008901:Mineralocorticoids; D009392:Nephrectomy; D051381:Rats; D011956:Receptors, Cell Surface; D012083:Renin / Q000097:blood*
D008901:Mineralocorticoids; D011956:Receptors, Cell Surface; D000738:Androsterone; D007610:Kallikreins; D012083:Renin