A reassessment of the phospholipid dependence of membrane-bound enzymes, with special reference to glucose-6-phosphatase and Na+, K+-dependent adenosine triphosphatase.
It is suggested that the specific involvement of phospholipid in either the expression or constraint of glucose-6-phosphatase activity is not conclusively established by the existing experimental evidence. The physiological significance of an apparent requirement for phosphatidylserine for Na+, K+-dependent adenosine triphosphatase activity is also questioned. The need for a critical reassessment of past conclusions in the light of present knowledge is emphasized.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D002614:Chelating Agents / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004355:Drug Stability; D004789:Enzyme Activation / Q000187:drug effects; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D002614:Chelating Agents; D003902:Detergents; D010743:Phospholipids; D012964:Sodium; D010740:Phospholipases; D005952:Glucose-6-Phosphatase; D000251:Adenosine Triphosphatases; D011188:Potassium