Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters.
The postsynaptic actions of some neurotransmitters may be mediated through cyclic nucleotides and cyclic nucleotide-dependent phosphorylation of specific membrane proteins in postsynaptic cells. In addition to providing a molecular basis for the actions of several neurotransmitters and of certain drugs affecting behaviour, the model suggests a mechanism by which neurotransmitter signals may be converted into electrophysiological responses in postsynaptic cells.
D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D005725:Ganglia, Autonomic; D008566:Membranes / Q000378:metabolism; D008959:Models, Neurological; D009130:Muscle, Smooth / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000502:physiology*; D010539:Permeability; D010710:Phosphates / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D011955:Receptors, Drug; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D009712:Nucleotides, Cyclic; D010710:Phosphates; D011506:Proteins; D011955:Receptors, Drug; D000242:Cyclic AMP; D006152:Cyclic GMP; D004298:Dopamine