In vitro demonstration of an endothelial proliferative factor produced by neural cell lines.
Cultured endothelial cells exhibit a six- to tenfold increase in thymidine labeling index in response to a soluble factor elaborated by clonal cell lines of neural origin. This factor, endothelial proliferation factor, appears to be a unique property of tumor cells and may mediate the vascularization of these neoplasms.
D001254:Astrocytoma / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects; D009363:Neoplasm Proteins / Q000494:pharmacology; D009380:Neoplasms, Nerve Tissue / Q000098:blood supply / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism; D013268:Stimulation, Chemical
D009363:Neoplasm Proteins