[Effects of concanavalin A on the adsorption and penetration of paramyxoviruses into cells].
The lectin concavaline A, when added to cell cultures of chick embryos and calf kidney one hour prior to their injection with the virus of the Newcastle disease and that of parainfluenza-3 in cattle produces no adverse effect on the cell receptors of these viruses. On cells treated with concavaline 60 per cent and more virions are adsorbed as compared with the untreated cells. This is explained by the fact that concavaline binds to the cellular and viral glucoproteins. Virions bound to concavaline do not penetrate into the cells. The titers of the paramyxoviruses obtained from lectin-treated cells were by 2 log. lower than the virus titers obtained from untreated cells. Mono- and bivalent concavalines inhibit more slightly the reproduction of para myxoviruses.
D000327:Adsorption; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured / Q000382:microbiology*; D002642:Chick Embryo; D003208:Concanavalin A / Q000494:pharmacology*; D037102:Lectins / Q000494:pharmacology; D009522:Newcastle disease virus / Q000187:drug effects; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D010252:Paramyxoviridae / Q000187:drug effects*; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D037102:Lectins; D003208:Concanavalin A
Vliianie na konkamavalin A vurku adsorbtsiiata i pronikvaneto na paramiksovirusite v kletkite