Effect of methyl methanesulphonate (MMS) and methylene dimethanesulphonate (MDMS) on the template activity of DNA isolated from MDMS-sensitive and -resistant Yoshida cells.
Both methylene dimethanesulphonate (MDMS) and methyl methanesulphonate (MMS) cause the template activity of Yoshida cell DNA to decrease in a dose-dependent manner. The MDMS-resistant subline of Yoshida tumour is less sensitive in terms of DNA template activity than the MDMS-sensitive subline towards both agents. Although the difference in sensitivity is not reflected in the survival data after each agent, it does suggest that the DNA from each cell line differs in its capacity to function as an efficient template.
D000818:Animals; D002460:Cell Line; D004273:DNA, Neoplasm / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D008698:Mesylates / Q000494:pharmacology*; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D012517:Sarcoma, Yoshida / Q000378:metabolism*; D013698:Templates, Genetic
D004273:DNA, Neoplasm; D008698:Mesylates; D008741:Methyl Methanesulfonate; D012321:DNA-Directed RNA Polymerases