title: Immunological sequelae of Trichinella spiralis infection in mice: effect on the antibody responses to sheep erythrocytes and Japanse B encephalitis virus.
abstract: Immunosuppression of the antibody response to Japanese B encephalitis (JBE) virus and sheep erythrocytes (SRBC) was observed in mice infected with Trichinella spiralis. This suppression was paralleled by the presence of fewer antibody-forming cells to SRBC in the spleens of parasitized mice. Both primary and secondary complement-fixing antibody responses to JBE virus were suppressed, but the development of immunological memory was not affected. Parasitized mice demonstrated a normal blastogenic response to phytohemagglutinin and normal serum clearance rate of injected (125)I-labeled immunoglobulin G(2b), although the size of the extravascular fluid compartment was significantly increased. The data presented here and in previous reports suggest that sequential antigenic competition is a possible explanation for the humoral immunosuppression to heterologous antigens caused by T. spiralis infection.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000956:Antigens, Viral; D003168:Complement Fixation Tests; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D004672:Encephalitis, Japanese / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D037102:Lectins; D008213:Lymphocyte Activation; D051379:Mice; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013936:Thymidine / Q000378:metabolism; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*; D014316:Tritium
chemical_list: D000956:Antigens, Viral; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D037102:Lectins; D014316:Tritium; D013936:Thymidine