title: Dependence of collagen synthesis by embryonic chick tendon cells on the extracellular concentrations of glutamine.
abstract: An agent in rheumatoid synovial fluid which stimulates collagen synthesis by embryonic chick tendon cells was identified as glutamine. The stimulating effect was observed only at a subnormal concentration of proline (0.02 mM). The concentration of glutamine in rheumatoid synovial fluid is about 2.5 mM but it falls rapidly during storage even at -20 degrees C. Collagen synthesis is shown to depend on the extracellular concentrations of glutamine and proline in addition to any connective tissue activating factors.
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis*; D005973:Glutamine / Q000494:pharmacology*; D011392:Proline / Q000494:pharmacology; D013582:Synovial Fluid; D013710:Tendons / Q000166:cytology / Q000378:metabolism*
chemical_list: D005973:Glutamine; D003094:Collagen; D011392:Proline