Effect of chloramphenicol on the electron systems in Ustilago cynodontis.
The mycelial cells of Ustilago cynodontis possess at least two electron transport systems: a cyanide-sensitive cytochrome pathway, which represents the major route for electron transport, and an alternative cyanide-insensitive pathway, inhibited by salicylhydroxamic acid. In the presence of chloramphenicol in the culture medium, mycelial cells respire only by the alternatuve chain. The stable induced yeast-like cells, obtained by prolonged chloramphenicol treatment of the mycelial cells, respire as the untreated mycelial cells; this result indicates that the phenotypic change induced by chloramphenicol is not related to a modification of the respiratory system.
D001386:Azides / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D002248:Carbon Monoxide / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology*; D003486:Cyanides / Q000494:pharmacology; D003580:Cytochromes / Q000378:metabolism; D004579:Electron Transport / Q000187:drug effects; D009243:NAD / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D014588:Ustilago / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D001386:Azides; D003486:Cyanides; D003580:Cytochromes; D009243:NAD; D002701:Chloramphenicol; D002248:Carbon Monoxide