title: [Alpha 1 antitrypsin deficiency and liver diseases].
abstract: Alpha-1 antitrypsin is mainly responsible for the inhibitory power with regard to serum of numerous enzymes, in particular, trypsin. Alpha-1 antitrypsin deficiency is linked to pulmonary and hepatic disease. The special characteristic constantly found during liver disease, associated with alpha-1 antitrypsin deficiency, is the existence of intra-cytoplasmic globules within the hepatocytes due to accumulation of alpha-1 antitrypsin. This latter enzyme differs chemically from serum alpha-1 antitrypsin.
mesh_terms: D000328:Adult; D000483:Alleles; D002648:Child; D004804:Eosinophils / Q000201:enzymology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology*; D008297:Male; D011656:Pulmonary Emphysema / Q000201:enzymology; D000515:alpha 1-Antitrypsin / Q000097:blood / Q000276:immunology; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000515:alpha 1-Antitrypsin
vernacular_title: Déficit en alpha-1-antitrypsine et affections du foie