Effect of visceral leishmaniasis on congenitally athymic mice.
Congenitally athymic mice were more susceptible to challenge with amastigotes of Leishmania donovani than were their thymus-intact littermates. This increased susceptibility correlated with a lack of Arthus and delayed-type responses when animals were skin tested with leishmanial antigen.
D000818:Animals; D000941:Antigens; D001183:Arthus Reaction / Q000276:immunology*; D005260:Female; D006968:Hypersensitivity, Delayed; D007891:Leishmania / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000276:immunology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens