The effect of exogenous 3':5'-adenosine monophosphate on urinary output in children with vasopressin-resistant diabetes insipidus.
The administration of c-AMP and DB c-AMP to six children with NDI has failed to yield an antidiuretic effect. From the present study it may be concluded that, at the doses used, neither c-AMP nor its dibutyryl derivative can mimic the action of ADH in NDI as they do in normal subjects. On the contrary, DB c-AMP increased urine volume and Cosm in a very marked way, without changing the creatinine excretion.
D003994:Bucladesine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D000242:Cyclic AMP / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy* / Q000652:urine; D004231:Diuresis; D005260:Female; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D009994:Osmolar Concentration; D014667:Vasopressins / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D014667:Vasopressins; D003994:Bucladesine; D003404:Creatinine; D000242:Cyclic AMP