[The neuronal Torres bodies in experimental yellow fever encephalomyelitis. An additional example of the heterogeneous nature of Cowdry type A intranuclear inclusions].
In experimental yellow fever virus encephalomyelitis of adult albino mice, the occurrence of intranuclear inclusions within nerve cells, in particular, within spinal and bulbar motoneurons, is a constant finding. The light microscopic features of these so-called neuronal Torres bodies correspond entirely to the criteria laid down by Cowdry for the type A intranuclear inclusions. At the ultrastructural level, these karyoplasmic formations consist of haphazardly distributed patches of an essentially amorphous material of various density. Unlike the Cowdry type A intranuclear inclusions characteristic of several herpesvirus and paramyxovirus infections, neuronal Torr-s bodies do not contain any viral structures. The frequency with which neuronal Torres bodies, certain nucleolar alterations and severe tigrolytic changes occur together, possibly indicates that this sort of type A intranuclear inclusion developes as a consequence of a virus induced disturbance of the cell nucleic acid and/or protein anabolism.
D000818:Animals; D000870:Anterior Horn Cells / Q000473:pathology; D001921:Brain / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure*; D002540:Cerebral Cortex / Q000473:pathology; D004195:Disease Models, Animal; D004679:Encephalomyelitis / Q000382:microbiology / Q000473:pathology*; D002479:Inclusion Bodies / Q000648:ultrastructure*; D051379:Mice; D009046:Motor Neurons / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology; D015005:Yellow fever virus
Die neuronalen Torres-Körperchen bei der experimentellen Gelbfieber-Encephalomyelitis. Ein weiteres Beispiel für die uneinheitliche Natur der Kerneinschlüsse vom Typ A nach Cowdry