[Cellular immune reactivity in patients with multiple myeloma].
The ConA-, PHA- and PWM-induced lymphocyte transformation rates were significantly decreased in 19 patients with multiple myeloma. Lymphocyte-inherent defects rather than serum factors seem to account for this decreased lymphocyte reactivity. In 58% of the patients a pathologically increased ConA-induced suppressor cell activity, which was negatively correlated with the non-paraprotein IgM-concentration, was found.
D006801:Humans; D007111:Immunity, Cellular; D007075:Immunoglobulin M / Q000032:analysis; D008213:Lymphocyte Activation; D009101:Multiple Myeloma / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007075:Immunoglobulin M
Zelluläre Immunreaktivität bei Patienten mit multiplem Myelom.