Lack of correlation between gonadotropin and adrenal androgen levels in agonadal children.
To evaluate the relationship between the secretion of gonadotropins and adrenal androgens, patients with gonadal agenesis were evaluated by (a) administering human luteinizing hormone (hLH) for 5 days with or without estrogen pretreatment to agonadal patients who had prepubertal LH levels; (b) correlating circulating gonadotropin levels with adrenal androgens in 45 patients; and (c) comparing adrenal androgens with gonadotropins after long-term administration of estrogen or androgens. Results are as follows: (a) No alteration in serum concentrations of dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), estrone (E1), testosterone (T), or in excretion of urinary 17-ketosteroid (17 KS) occurred after the administration of hLH. (b) No clearcut relationship between endogenous level of LH or FSH and DHA OR DHAS was demonstrated although a coincident increase of all hormones with age occurred. (c) Administration of estrogen to patients with gonadal agenesis did not affect their levels of DHA and DHAS although those patients given androgen developed higher DHAS, but not DHA, levels. Hence, increasing gonadotropin concentrations would not appear to be a primary etiologic factor in the maturation of the adrenal.
D015068:17-Ketosteroids / Q000652:urine; D000305:Adrenal Cortex Hormones / Q000032:analysis*; D000728:Androgens / Q000032:analysis*; D003687:Dehydroepiandrosterone / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D004970:Estrone / Q000097:blood; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D005474:Fluoxymesterone / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood* / Q000627:therapeutic use; D010074:Oxandrolone / Q000627:therapeutic use; D011627:Puberty; D013431:Sulfates / Q000097:blood; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D014424:Turner Syndrome / Q000097:blood* / Q000188:drug therapy
D015068:17-Ketosteroids; D000305:Adrenal Cortex Hormones; D000728:Androgens; D004966:Estrogens, Conjugated (USP); D013431:Sulfates; D004970:Estrone; D013739:Testosterone; D004997:Ethinyl Estradiol; D003687:Dehydroepiandrosterone; D010074:Oxandrolone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005474:Fluoxymesterone