Effect of beta-oxidized nitrosamines on syrian hamsters. III. 2,2'-Dihydroxydi-n-propylnitrosamine.
2, 2-Dihydroxy-di-n-propylnitrosamine (DHPN), an assumed metabolite of di-n-propylnitrosamine (DPN), injected subcutaneously once weekly for life, was carcinogenic in Syrian hamsters. The main target organs were the respiratory tract, pancreas, liver, and kidneys. In the respiratory system the most affected segments were the nasal cavities and the lungs. Adenomas and adenocarcinomas, mostly of ductal origin, were induced in the pancreas. Liver neoplasms were hemangloendotheliomas, angiosarcomas, hepatocellular adenomas, cholangiomas, and cholangiocarcinomas. Kidney neoplasms were adenomas and adenocarcinomas. The morphology of the induced neoplasms was described, as well as the effects of DHPN, compared to those another possible metabolite of DPN, 2-hydroxypropyl-n-propylnitrosamine (2-HPPN), which is formed in vivo with only 1 aliphatic chain degraded via theta-oxidation.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D002759:Adenoma, Bile Duct / Q000139:chemically induced; D000818:Animals; D001984:Bronchial Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D006224:Cricetinae; D005260:Female; D005706:Gallbladder Neoplasms / Q000139:chemically induced; D006390:Hemangioendothelioma / Q000139:chemically induced; D006394:Hemangiosarcoma / Q000139:chemically induced; D007680:Kidney Neoplasms / Q000139:chemically induced; D007822:Laryngeal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D009669:Nose Neoplasms / Q000139:chemically induced; D010084:Oxidation-Reduction; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D014134:Tracheal Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines