title: Amino acid and hexose transport of normal and simian virus 40-transformed human cells.
abstract: Studies on amino acid and hexose transport were performed on human WI-38 cells and WI-38 SV40-transformed cells (VA13A and VA13-2RA). Depending upon cell line or conditions, either no difference or a relative decrease in initial uptake by transformed cells was found. Under similar growth conditions, transformed hamster cells (PyBHK-21/C13) had increased uptake, compared with the normal hamster cells (BHK-21/C13). The normal and transformed human cells were also similar in sialic acid content and agglutinated when treated with concanavalin A.
mesh_terms: D000372:Agglutination Tests; D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006224:Cricetinae; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D006801:Humans; D012794:Sialic Acids / Q000032:analysis; D013539:Simian virus 40
chemical_list: D000621:Aminoisobutyric Acids; D003837:Deoxy Sugars; D012794:Sialic Acids; D003208:Concanavalin A; D003847:Deoxyglucose