Dopamine-induced amylase secretion from guinea-pig submandibular gland.
1. The effects of dopamine, 5-hydroxydopamine (5-OHDA) and noradrenaline on amylase secretion from the guinea-pig submandibular gland were investigated under in vitro conditions. 2. All three amines greatly enhanced amylase secretion. Blockade of dopamine beta-hydroxylase did not inhibit the response to dopamine. 3. Noradrenaline and dopamine stimulated amylase release from salivary glands of reserpine-treated animals, whereas 5-OHDA had no stimulatory effect on secretion in guinea-pigs pretreated with reserpine. 4. Haloperidol completely inhibited dopamine-induced enzyme discharge, but did not affect noradrenaline-initiated secretion. 5. Apomorphine caused a slight enzyme release by itself; it diminished the dopamine secretory effect, but did not modify that of noradrenaline. 6. Pimozide and fluspirilene attenuated the dopamine-induced enzyme discharge, but compared with haloperidol they were less effective. 7. It is concluded that dopamine exerts a secretagogic action different from that of noradrenaline. The possible presence of a specific dopamine receptor in salivary glands is discussed.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D006168:Guinea Pigs; D006892:Hydroxydopamines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D014149:Tranquilizing Agents / Q000494:pharmacology
D006892:Hydroxydopamines; D014149:Tranquilizing Agents; D012110:Reserpine; D004050:Ditiocarb; D000681:Amylases; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine