The effects of cholera toxin on the adrenal weight in hypophysectomized rats.
The effects of cholera on adrenal weight in hypophysectomized rats were investigated, in an attempt to demonstrate an ACTH-like, adrenal trophic effect of the toxin. The results suggested that the toxin probably exerts is ACTH-like action on the adrenal via adenylate cyclase. Cholera toxin was also shown to have a thermolytic action, similar to that of ACTH, probably due to stimulation of adrenal glucocorticoid secretion.
D000311:Adrenal Glands / Q000033:anatomy & histology* / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001835:Body Weight; D004731:Endotoxins / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D009929:Organ Size; D009928:Organ Specificity; D051381:Rats; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013950:Thymus Gland / Q000033:anatomy & histology / Q000187:drug effects; D014734:Vibrio cholerae
D004731:Endotoxins; D000324:Adrenocorticotropic Hormone