title: [Determination of individual sensitivity of gastric cancer to 5-fluorouracil by tumor tissue respiratory and glycolytic indices].
abstract: Eighty one patients were studied for individual susceptibility of gastric tumors to 5-FU as evidenced by endogenic respiration and glycolysis of fresh tumor sections, the main criterion being the suppressed respiration, the accessory one  inhibition of glycolysis. Three groups of tumors were differentiated: susceptible (25.9%), slightly susceptible (28.4%) and unsusceptible (45.7%) to 5-fluoruracil. Mostly adenocarcinomas were found in a group of susceptible tumors, scirrhous and colloid cancers -- in an unsusceptible group. A correlation outlined between the results of determining susceptibility in vitro and clinical data enabled to recommend the method of determining susceptibility to 5-FU for clinical application.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism; D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000378:metabolism; D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy / Q000378:metabolism; D002277:Carcinoma / Q000188:drug therapy / Q000378:metabolism; D005472:Fluorouracil / Q000627:therapeutic use*; D006019:Glycolysis; D006801:Humans; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D010101:Oxygen Consumption; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D005472:Fluorouracil
vernacular_title: Opredelenie individual'noĭ chuvstvitel'nosti raka zheludka k 5-ftoruratsilu po pokazatelaim dykhaniia i glikoliza  opukholevoĭ tkani