Plasma alkaline phosphatase in mice with experimentally-induced osteosarcomas.
No statistically significant difference in alkaline phosphatase levels was demonstrated in animals injected with the FBJ virus. However, there was a significant increase associated with the development of osteosarcomas in response to the iv injection of 1.0 uCi 90 Sr/g body weight into 11-18-mo-old Anl:CFl females. It was proposed that alkaline phosphatase determinations can be used as well as roentenographic analysis to detect 90Sr-induced tumors in mice.
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000201:enzymology / Q000662:veterinary*; D005260:Female; D017988:Gammaretrovirus; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000201:enzymology / Q000662:veterinary; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000201:enzymology / Q000662:veterinary*; D011859:Radiography; D012376:Rodent Diseases / Q000000981:diagnostic imaging / Q000201:enzymology*; D012513:Sarcoma, Experimental; D013326:Strontium Radioisotopes
D013326:Strontium Radioisotopes; D000469:Alkaline Phosphatase