Growth following renal transplantation in children and adolescents.
Growth following renal transplantation in children and adolescents. Sixteen children who received a cadaveric renal transplant surviving 1 to 5 years, had their growth rate assessed while receiving 10 to 25 mg of prednisone every 48 hours. Six of 9 patients witha a bone age of 12 years or less grew at a "normal" rate. None of the patients whose bone age was greater than 12 years grew at a "normal" rate. Since low-dose alternate-day prednisone therapy allows for optimal growth but does not appear to compromise kidney survival, we feel such a regime should be instituted in growing children receiving a kidney transplant.
D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006128:Growth / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D011241:Prednisone