[Correlation between immunological reactivity and the fat-carbohydrate metabolism. Influence of phenformin].
Based on the conceptions of the relationship between energy and adaptation-immunological systems a number of hormone-metabolic indices were compared with immune reactivity as evidenced by skin tests and rosette-formation reaction. It is shown that lowering of immunological indices in oncological patients is associated with a decreased sensitivity of dexametasone suppression of cortisol, an increased concentration of 11-oxycorticosteroids in blood, a higher level of triglycerides, cholestrol, beta-lipoproteins and less glucose tolerance. The use of phenformin during 3 months in patients with atherosclerosis resulted in a considerable increase of the index of phytohemagglutinin stimulated blasttransformation of lymphocytes and rosette-formation reaction. This effect was associated with normalization of lipid metabolism indices.
D015065:17-Hydroxycorticosteroids / Q000378:metabolism; D015068:17-Ketosteroids / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D000368:Aged; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010629:Phenformin / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D008077:Lipoproteins, LDL; D014280:Triglycerides; D003907:Dexamethasone; D002784:Cholesterol; D010629:Phenformin; D005947:Glucose; D006854:Hydrocortisone
Korreliatsiia mezhdu immunologicheskoĭ reaktivnost'iu i zhiro-uglevodnym obmenom. Vliianie fenformina