Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.
Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-beta-d-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-beta-d-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.
D000085:Acetates / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D006561:Herpes Simplex / Q000188:drug therapy*; D051379:Mice; D063065:Organophosphonates / Q000627:therapeutic use*; D018139:Simplexvirus
D000085:Acetates; D000998:Antiviral Agents; D063065:Organophosphonates