[Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)].
The chronic administration of diethylnitrosamine in drinking water induces liver tumors in the rat. The preneoplastic period may be divided in two phases differing mainly in the loss of circadian control of mitotic activity in hepatocytes.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D004052:Diethylnitrosamine; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000032:analysis; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009602:Nitrosamines; D010504:Periodic Acid; D011230:Precancerous Conditions; D051381:Rats; D012545:Schiff Bases
D008112:Liver Glycogen; D009602:Nitrosamines; D012545:Schiff Bases; D010504:Periodic Acid; D004052:Diethylnitrosamine
Activité mitotique lors de la période prénéoplasique précédant la cancérisation du foie par la diethylnitrosamine