Reovirus antibody patterns in dogs: a trial for the application of principal component analysis to seroepidemiology.
In 100 dogs in Morioka and its vicinity serologically surveyed for reovirus infection, there were significant correlations between hemagglutination-inhibiting and neutralizing antibody titers of the same virus types. In order to establish a proper index for the evaluation of infection, principal component analysis was applied to the analysis of data, including standard immune sera. Of nine samples of matrix examined, correlation matrix of 6 variables was suggested to afford the most proper result. Essential information from the original data was accounted for by factor loadings of the first 3 components. The 6 attributes of serum antibody were classified into three groups. In a scatter diagram serum samples were classified also into three major groups corresponding to the three reovirus types, and the serotypic pattern of infection was clearly visualized.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D003201:Computers; D004283:Dog Diseases / Q000276:immunology; D004285:Dogs / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D009500:Neutralization Tests; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology / Q000662:veterinary; D013223:Statistics as Topic
D000914:Antibodies, Viral