[Effect of long-term phenytoin treatment on the levels of calcium and magnesium in rat femurs].
In young male rats, long-term treatment with phenytoïn reduces the amount of calcium and magnesium in the femurs and provokes a stimulation of the parathyroiïds witnessed by the hypertrophy and hyperplasy of the parathyroid cells. Neither plasma calcium nor plasma and erythrocyte magnesium are modified.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D006984:Hypertrophy; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects / Q000473:pathology; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D010672:Phenytoin; D008274:Magnesium; D002118:Calcium
Influence d'un traitement prolongé par la phénytoïne sur le taux du calcium et du magnésium de fémurs de rats.