[Detection of the range of cytological changes in tumors induced in rats by nitrosoamines by means of passage in the anterior chamber of the eye].
12 rat liver tumors (high, purely and low differentiated hepatomas and adenocarcinomas), 3 kidney tumors, 1 lymphosarcoma and 1 round cell sarcoma of the uterus were transplanted and passed trough anterior chamber of the allogenic rat eyes. In 8 primary transplants of the liver tumors differentiation traits increased; three of them were morphologically undistinguishable from the normal liver tissue. In some transplants of embryonic liver and kidney displasia was detected. The results obtained give evidence in favor of a very high cytological variability of tumors at the early steps of progression, and indicate that the cultivation in the anterior chamber of the eye may be a proper model for investigation of cytological variability of both malignant and normal tissues.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D000867:Anterior Chamber; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D005134:Eye Neoplasms / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D007680:Kidney Neoplasms / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology
D009602:Nitrosamines
Vyiavlenie diapazona tsitologicheskikh izmeneniĭ opukholeĭ, indutsirovannykh u krys nitrozaminami, metodom passirovaniia v peredeneĭ kamere glaza