[Effect of carbidine on the process of adrenergic neurotransmission].
Methods of physiological analysis were applied to a study of the effect of an original psychotropic agent--carbidine--on the process of adrenergic neurotransmission on a model of an isolated rat Vas deferens. The noradrenaline (NA) content was determined in the same ductus spectrofluorimetrically; the capacity of the neuroleptic to block the consumption of the exogenous NA by the tissue was also investigated. Carbidine proved to possess an adrenomimetic effect caused by it capacity to release NA, leading to a reduction of endogenous neuromediator stores.
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000294:innervation*; D009638:Norepinephrine / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects / Q000378:metabolism
D002243:Carbolines; D007211:Indoles; D011619:Psychotropic Drugs; D009638:Norepinephrine
Vliianie karbidina na protsess adrenergicheskoĭ neĭroperedachi