[Experimental studies of the distribution of intravenously injected iodine-labeled cytonal (diethylstilbestrol diphosphate)].
After intravenous injection the distribution of iodine-labelled diethylstilbestral-diphosphate (cytonal) was investigated in various organs of the rat. For this purpose the concentration of activity in the organs of the animals were established by measurements of specimens in the bore-hole counter and scintigrams were made by means of a small animal scanner. The result was an unequivocal temporary dependence of the enrichment of the substance in the organs. The greatest enrichment was found 10 minutes after injection in the liver, then followed blood, kidneys, adrenal glands, seminal vesicles, prostate, abdominal wall and the fatty tissue surrounding the prostate. The blood activity relatively decreased. 7 days after injection an unambiguously higher activity was to be proved in the liver, kidney, adrenal gland than in the blood, whereas the enrichment of iodine-labelled diethylstilbestraldiphosphate in prostate, seminal vesicle, fatty and muscular tissue was always below the enrichment of the blood. But in every case the relation of organ activity to blood activity changed in favour of the organ activity, also with regard to the prostate. 10 minutes after injection the concentration of the activity of the seminal vesicle was somewhat higher than that one of the prostate, but in the further course it was below the concentration of the activity of the prostate. During the first two hours the fatty tissue surrounding the prostate showed a clearly and after the third day a slightly lower activity concentration than the prostate. On the basis of this distribution of the activity for the scintigraphy of the prostate above all a temporary interval of about 10 minutes to 3 hours after the injection of labelled cytonal is involved. The results cause us to perform investigations in men concerning the pharmacokinetics and the possibility of using radioactively labelled cytonal.
D000009:Abdominal Muscles / Q000032:analysis; D000311:Adrenal Glands / Q000032:analysis; D000818:Animals; D004054:Diethylstilbestrol / Q000008:administration & dosage* / Q000097:blood; D007275:Injections, Intravenous; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D011467:Prostate / Q000032:analysis; D051381:Rats; D012669:Seminal Vesicles / Q000032:analysis; D014018:Tissue Distribution
D004054:Diethylstilbestrol
Experimentelle Untersuchungen über die Verteilung von intravenös injiziertem jodmarkiertem Cytonal (Diäthylstilböstroldiphosphat).