[Effect of inorganic phosphorus on the biosynthesis of polymyxin B].
A synthetic medium containing optimal levels of the sources of carbon, nitrogen and inorganic phosphorus and providing satisfactory yields of polymyxin B was developed for 2 strains of Bac. polymyxa 933 and VK-153. The consumption of phosphorus in the medium by the strains and the antibiotic biosynthesis levels depended on the form of phosphorus added to the medium. Optimal biosynthesis of polymyxin B was observed at lower concentration levels of soluble soluble phosphorus in the medium than the bacterial growth.
D001407:Bacillus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D010758:Phosphorus / Q000494:pharmacology*; D011113:Polymyxins / Q000096:biosynthesis*
D003470:Culture Media; D011113:Polymyxins; D010758:Phosphorus
Vliianie neorganicheskogo fosfora na biosintez polimiksina B