[Mouse pancreas involvement in murine hepatitis virus infection].
After intraperitoneal inoculation with mouse hepatitis virus (MHv) into mice, the excretory cells of the pancreas showed a marked vacuolar degeneration concomitantly with hepatitis. MHV-specific antigen was evidenced in the cytoplasm of infected cells. Electron microscopy revealed a number of virions within the matrix, spaces of the endoplasmic reticulum and areas of focal cytoplasmic necrosis. The virus titer of the pancreas was equal or superior to that of the liver at least in early stage of infection.
D000818:Animals; D006520:Hepatitis, Animal / Q000473:pathology*; D008099:Liver / Q000382:microbiology; D051379:Mice; D006517:Murine hepatitis virus / Q000276:immunology / Q000648:ultrastructure; D010179:Pancreas / Q000382:microbiology / Q000473:pathology* / Q000648:ultrastructure; D013154:Spleen / Q000382:microbiology
Implication pancréatique chez la souris infectée avec le virus de l'hépatite murine