The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.
Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis. The salivary exocrinopathy is characterized by increased amounts of PAS-reactive mucoprotein in the acinar cells and by obstruction and dilatation of ducts by precipitated material with the same staining characteristics as those found in the acinar elements.
D000818:Animals; D001835:Body Weight; D002467:Cell Nucleus / Q000648:ultrastructure; D003550:Cystic Fibrosis / Q000139:chemically induced*; D003593:Cytoplasm / Q000648:ultrastructure; D004195:Disease Models, Animal; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D007274:Injections, Intraperitoneal; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D009077:Mucins / Q000378:metabolism; D009088:Mucoproteins / Q000378:metabolism; D009929:Organ Size; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000008:administration & dosage; D013268:Stimulation, Chemical; D013363:Submandibular Gland / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D009435:Synaptic Transmission / Q000187:drug effects
D009077:Mucins; D009088:Mucoproteins; D010862:Pilocarpine; D012110:Reserpine; D007545:Isoproterenol