[Ultrastructure and hormone secretion of a tissue culture from an adrenal gland tumor simulating Cushing's syndrome].
Tissue cultures of a surgically removed adrenocortical tumour causing Cushing's syndrome, and tissue cultures from the attached, tumour-free adrenal were studied. There were two cell types characteristic of tumour tissue. The cell type occurring most frequently had pronounced hypertrophied agranular endoplasmic reticulum. A fewer number of lipidrich cells containing many electron-dense granules could also be found. The ratio of cells changed during cultivation. In the 17 days tumour culture, a higher percentage of lipid-rich cells could be observed. In spite of continuous ACTH treatment, the initially high hydrocortisone level decreased, gradually. It may be assumed that the lipid-rich cells are of reduced ability as regards hydrocortisone production.
D000302:Adrenal Cortex / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000473:pathology*; D000311:Adrenal Glands / Q000473:pathology / Q000648:ultrastructure; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage; D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D066298:In Vitro Techniques; D012636:Secretory Rate
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Cushing syndromát okozó mellékvese-tumor szövettenyészetńek finomszerkezete és hormontermelśe