Chronic inhalation of nickel oxide and cigarette smoke by hamsters.
Chronic inhalation of NiO and cigarette smoke (CS) by hamsters eventually caused pneumoconiosis whose development was unaffected by CS. No carcinogenic or cocarcinogenic effect of NiO and CS was observed, CS exposure increased laryngeal lesions, reduced body weight, and increased lifespan.
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004781:Environmental Exposure; D002479:Inclusion Bodies / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D009532:Nickel / Q000633:toxicity*; D011009:Pneumoconiosis / Q000139:chemically induced*; D011650:Pulmonary Alveoli / Q000648:ultrastructure; D012906:Smoke
D000393:Air Pollutants; D012906:Smoke; D009532:Nickel