Neural properties of cultured human endocrine tumor cells of proposed neural crest origin.
Cells from human endocrine tumors of proposed neural crest origin--five pheochromocytomas, two medullary carcinomas of the thyroid, and two bronchial carcinoids--were grown in monolayer culture. Cells from all nine tumors, including epithelial forms of medullary carcinoma of the thyroid and bronchial carcinoid cells, and epithelial and neuron-like pheochromocytoma cells demonstrated all-or-nothing, short-duration action potentials.
D000200:Action Potentials; D000311:Adrenal Glands / Q000196:embryology* / Q000502:physiology*; D001980:Bronchi / Q000196:embryology / Q000502:physiology*; D002277:Carcinoma; D003528:Carcinoma, Adenoid Cystic; D002478:Cells, Cultured; D010673:Pheochromocytoma / Q000473:pathology; D013961:Thyroid Gland / Q000196:embryology / Q000502:physiology*