Cross-reactive cytotoxic responses. H-2 restricted are more specific than anti-H-2 responses.
Cross-reactive T-cell cytotoxicity is seen when cytotoxic responses are generated in mixed lymphocyte cultures either between mouse strans which differ at the major histocompatibility complex, H-2, or between H-2b mutant strains and the strain from which they were derived. This cross-reactivity can be measured with [51Cr] labeled target cells from a number of different H-2 haplotypes, and the pattern of cross-reaction indicates that the target antigens are unlikely to be any of the serologically defined public specificities. In contrast, the specificity of H-2 restricted cytotoxic responses, such as that to the male-specific antigen, H-Y, is exquisite, and male cells from strains of mice carrying H-2 haplotypes other than the responder have never been found to act as appropriate targets. The contrast between the specificity of anti-H-2 and H-2 restricted responses may argue for a greater idiotypic homogeneity of the cells makiing H-2 restricted responses, and the greater specificity of these responses may be necessary for their biological function.
D000818:Animals; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D005260:Female; D006084:Graft Rejection; D006183:H-2 Antigens; D006182:H-Y Antigen; D007156:Immunologic Memory; D007519:Isoantigens; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D006182:H-Y Antigen; D007519:Isoantigens