[Cellular energy functions of a subline of mouse fibroblasts resistent to the action of ethidium bromide].
The respiration of subline Leb-25 cells, resistant to ethidium bromide (EB, 25 g/ml), is 2.5 times slower than the respiration of parental L cells of mouse fibroblasts. The EB resistant cells have a normal level of ATP. Disturbances of mitochondrial functions can be observed such as a defect of the succinate dehydrogenase complex and the uncoupling of respiration and oxidative phosphorylation in mitochondria of Leb-25 cells.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D004351:Drug Resistance; D004734:Energy Metabolism / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D004996:Ethidium / Q000037:antagonists & inhibitors*; D005347:Fibroblasts / Q000187:drug effects*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D004996:Ethidium
Izuchenie nekotorykh énergeticheskikh funktsiĭ kletok sublinii myshinykh fibroblastov, rezistentnoĭ k deĭstviiu bromistogo étidiia.