Evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections.
The potential antiviral activity of 6-azauridine and 5-iododeoxyuridine was evaluated in a coordinated study at five institutions. Experimental models in five species, the mouse, rabbit, swine, cat, and ferret, were established with use of 10 viruses: Herpesvirus hominis types 1 and 2, murine cytomegalovirus, vaccinia virus, Shope fibroma virus, transmissible gastroenteritis virus, swine influenza virus, feline viral rhinotracheitis virus, feline panleukopenia virus, and ferret distemper virus. Criteria for selection were: (1) representation from a number of major groups of viruses, (2) reproduction of natural routes of infection, and (3) simulation of potentially treatable viral infections of man. Antiviral activity was observed for 5-iododeoxyuridine in H. hominis infections in hairless mice and influenza in swine, and a slight degree of efficacy was noted in rabbits infected with Shope fibroma virus. Toxicity was also observed in most of the experimental models. There was a suggestion of antiviral activity with 6-azauridine in swine infected with transmissible gastroenteritis virus; however, enhancement of disease and some toxicity were seen in most of the other models. Efficacy of these two compounds was not well substantiated by these studies.
D000818:Animals; D001380:Azauridine / Q000627:therapeutic use*; D002415:Cats; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D004216:Distemper / Q000188:drug therapy; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005254:Feline Panleukopenia / Q000188:drug therapy; D005260:Female; D005289:Ferrets; D005761:Gastroenteritis, Transmissible, of Swine / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D007065:Idoxuridine / Q000627:therapeutic use*; D009980:Influenza A virus / Q000187:drug effects; D008297:Male; D051379:Mice; D011817:Rabbits; D012220:Rhinitis / Q000188:drug therapy; D013552:Swine; D014136:Tracheitis / Q000188:drug therapy; D014412:Tumor Virus Infections / Q000188:drug therapy; D014615:Vaccinia / Q000188:drug therapy; D014777:Virus Diseases / Q000188:drug therapy*
D001380:Azauridine; D007065:Idoxuridine