Effects of starvation and Ca++ on glucose-induced accumulation of cyclic 3',5'-AMP in pancreatic islets.
Exposure to glucose in the presence of 3-isobutyl-1-methylxanthine leads to accumulation of cAMP in islets microdissected from ob/ob mice. This process is dependent on extracellular Ca++ but differs markedly from the glucose action on insulin release in the same in vitro system in disappearing after 18 h of starvation.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D000242:Cyclic AMP / Q000096:biosynthesis* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008820:Mice, Obese; D010726:Phosphodiesterase Inhibitors; D013217:Starvation / Q000378:metabolism; D014970:Xanthines / Q000494:pharmacology
D007328:Insulin; D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D000242:Cyclic AMP; D005947:Glucose; D002118:Calcium