Substrate specificity of vetebrate collagenase.
Substrate specificity of purified tadpole collagenase (EC 3.4.24.3) has been studied using eleven synthetic peptides. A pentapeptide, t-butyloxycarbonylprolylalanylglycylisoleucylalanine amide, was susceptible to the action of the enzyme and an octapeptide, acetylprolylglutaminylglycylisoleucylalanylglycylglutaminylarginine ethyl ester, was proposed to be the best substrate for vertebrate collagenase among the peptides tested.
D000818:Animals; D007700:Kinetics; D003012:Microbial Collagenase / Q000378:metabolism*; D009842:Oligopeptides; D013329:Structure-Activity Relationship
D009842:Oligopeptides; D003012:Microbial Collagenase