Immunosuppressive effect of concanavalin-A. I. Suppression of generation of cytotoxic lymphocytes in MLC.
The effect of Con-A on the generation of cytotoxic lymphocytes (CL) in one way MLC was studied using mouse model. Mitogenic doses of Con-A substantially inhibited primary and secondary CL responses. Spleen cells after in vivo activation by Con-A revealed complete lack of ability to respond in allogeneic MLC. When such cells were added to normal responding cells, even at low proportion, CL generation in primary MLC was also diminished. These observations support the hypothesis that immunosuppressive effect of Con-A is exerted by stimulation of suppressor cells.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D013154:Spleen / Q000276:immunology
D003208:Concanavalin A