Induction of antiviral activity in vivo and in vitro by human placenta ribonucleic acid treated with nitrous acid.
Induction of antiviral activity and interferon by human placenta ribonucleic acid deaminated with sodium nitrite (NO2-RNA) was studied in vitro and in vitro. (1) Viral multiplication in diploid cells from human kidney (HK cells) was depressed by pretreatment with NO2-RNA, but not by pre-treatment with the original placenta RNA. (2) NO2-RNA showed an interferon-inducing activity in rabbits and mice. (3) NO2-RNA sedimenting in 18 S and 28 S regions showed a higher antiviral activity than that sedimenting in 4 S region.
D000225:Adenine / Q000032:analysis; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003596:Cytosine / Q000032:analysis; D005260:Female; D006147:Guanine / Q000032:analysis; D006801:Humans; D007042:Hypoxanthines / Q000032:analysis; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D051379:Mice; D009573:Nitrites / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology*; D010920:Placenta; D011247:Pregnancy; D012313:RNA / Q000032:analysis / Q000494:pharmacology*; D011817:Rabbits; D014498:Uracil / Q000032:analysis; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development; D014970:Xanthines / Q000032:analysis
D007042:Hypoxanthines; D009573:Nitrites; D014970:Xanthines; D014498:Uracil; D006147:Guanine; D012313:RNA; D003596:Cytosine; D007372:Interferons; D000225:Adenine; D009608:Nitrous Acid