[Mechanism of changes in oxidative phosphorylation in the kidney in nephropathy caused by post-transfusion complications].
A decrease in cytochrome c oxidase activity was observed in kidney tissue within 40 min after the transfusion of incompatible blood; at the same time, the succinate dehydrogenase activity was not altered. Opposite ratios (as compared with normal kidney) of the enzymatic activities were found within 24 hrs after a heterohemotransfusion. An addition of 5 M succinate to the kidney homogenate in vitro or administration of the substance at a dose of 8 mg per 100 g of body weight in vivo caused an activation of free oxidation and a decrease of phosphorylation. The addition of 50 M succinate, combined with hexokinase and NADH2, into the homogenate distinctly increased both the rate of tissue respiration and the coupled phosphorylation.
D001787:Blood Group Incompatibility; D003576:Electron Transport Complex IV / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D007674:Kidney Diseases / Q000201:enzymology* / Q000209:etiology; D009243:NAD / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D013385:Succinate Dehydrogenase / Q000378:metabolism; D065227:Transfusion Reaction
D009243:NAD; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D006593:Hexokinase
Nekotorye mekhanizmy izmeneniia okislitel'nogo fosforilirouaniia v pochke pri nefropatii, sviazannoĭ s posttransfuzionnumi olsozhneniiami