[Participation of Mg2+ and Ca2+ ions and the corresponding ATPases in the mechanism of the presynaptic action of amisyl and arecoline].
Amisyle and arecoline were found to be antagonistic drugs in the effect on content of Mg2+ and Ca2+ and on activity of corresponding ATPases in synaptosomes isolated from rat brain. Amisyle promoted the incorporation of 45Ca into synaptosomes but arecoline inhibited the reaction. The appear to be responsible for liberation and maintaining of neurotransmitters in presinaptic stores.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001535:Benactyzine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002413:Cations, Divalent; D004789:Enzyme Activation / Q000187:drug effects; D008274:Magnesium / Q000378:metabolism*; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D002413:Cations, Divalent; D001115:Arecoline; D001535:Benactyzine; D000251:Adenosine Triphosphatases; D000252:Calcium-Transporting ATPases; D008274:Magnesium; D002118:Calcium
Uchastie ionov Mg2+, Ca2+ i sootvetstvuiushchikh ATF-az v mekhanizme presinapticheskogo deĭstviia amizila i arekolina.