[The functional state of the adrenal cortex in patients with gonadal dysgenesis and a female phenotype].
Excretion of 17-KS and 17-OCS was studied in the urine of 86 patients with various cytogenetic variants of gonad dysgenesis of a female phenotype under basic conditions and after ACTH stimulation; in 10 patients endogenous hypophyseal ACTH reserve after block of the adrenal cortex by metopyrone was investigated as well.  A conclusion was drawn on the presence in these patients of differnet types of deviations of the adrenal gland function.  In some of the cases there is a primary "global" or dissociated injury of the adrenal cortex, apparently directly associated with gonosome anomaly; in other cases--with disturbed regulation of ACTH secretion.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology*; D000311:Adrenal Glands / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D005260:Female; D006801:Humans; D008797:Metyrapone; D009030:Mosaicism; D012730:Sex Chromosomes; D014424:Turner Syndrome / Q000235:genetics / Q000503:physiopathology* / Q000652:urine
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000324:Adrenocorticotropic Hormone; D008797:Metyrapone
Funksional'noe sostoianie kory nadpochechnikov u bol'nykh gonadnoĭ disgenezieĭ s zhenskim fenotipom