Thyroid hormones: effect of physiological concentrations on cultured cardiac cells.
Cultured cardiac cells prepared from newborn rat heart will respond in vitro to physiological concentrations of L-triiodothyronine. The cells are grown in a culture medium that contains hypothyroid calf serum. A dose response relationship of L-triiodothyronine indicates that this system may be a useful model for elucidation of the mechanism of thyroid hormone effects on the heart.
D000818:Animals; D000831:Animals, Newborn; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface; D014284:Triiodothyronine / Q000378:metabolism / Q000494:pharmacology*
D011956:Receptors, Cell Surface; D014284:Triiodothyronine; D005947:Glucose