Expression of the human adenylate kinase isozymes, phosphopyruvate hydratase, 6-phosphogluconate dehydrogenase, and phosphoglucomutase-1 in man-rodent somatic cell hybrids.
The expression of the adenylate kinase isozymes and of phosphopyruvate hydratase was studied in man-mouse and man-hamster hybrid clones. Concordant segregation of the loci coding for AK-2 and PPH was observed in 54 of 55 primary hybrid clones, and these loci were demonstrated to be synthetic with the loci specifying PGM-1 and PGD. The pattern of expression of the four enzymes in discordant clone suggests the gene order 1pter-(PGD, PPH)-AK-2-PGM-1-centromere. In addition, AK-1 was found to be expressed independently of AK-2.
D000263:Adenylate Kinase / Q000378:metabolism*; D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D002999:Clone Cells; D005260:Female; D006801:Humans; D006822:Hybrid Cells / Q000196:embryology*; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D051379:Mice; D010733:Phosphoglucomutase / Q000378:metabolism*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D014178:Translocation, Genetic
D007527:Isoenzymes; D010734:Phosphogluconate Dehydrogenase; D010770:Phosphotransferases; D000263:Adenylate Kinase; D010751:Phosphopyruvate Hydratase; D010733:Phosphoglucomutase