Evaluation of different antibiotic actions combined with rifampicin. In vitro synergism against Pseudomonas and Proteus.
Associations of penicillin, streptomycin, tetracycline and polymyxin B with rifampicin were tested for synergism against Pseudomonas and Proteus pathological strains. The combination of rifampicin and polymyxin B was clearly synergistic for all strains as it was evaluated by isobolograms and killing curvesmthe bactericidal action of this association, without any cross-resistance between its components, may eradicate gram-negative bacteria infections with marked polyvalent drug resistances.
D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D011113:Polymyxins / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects*; D011514:Proteus vulgaris / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
D011113:Polymyxins; D013752:Tetracycline; D010400:Penicillin G; D012293:Rifampin; D013307:Streptomycin