Proflavine photodynamic viral inactivation in herpes simplex keratitis.
We used the photodynamic inactivation technique with proflavine as the photoactive dye to treat herpetic epithelial keratitis in a preliminary study of patients who had idoxuridine toxicity or resistance. A comparative study with idoxuridine in treating dendritic ulcerations of the cornea showed a good therapeutic effect. But the investigation was suspended when adverse reactions, consisting of a generalized epithelial keratitis and an anterior uveitis, possibly of phototoxic origin, developed in a few patients receiving treatment. The ulcers treated by photodynamic inactivation apparently healed by a process of "debridement" followed by subsequent re-epithelialization.
D000166:Acridines / Q000627:therapeutic use*; D000328:Adult; D000867:Anterior Chamber; D001623:Betamethasone / Q000627:therapeutic use; D004487:Edema / Q000209:etiology; D005260:Female; D006801:Humans; D007065:Idoxuridine / Q000627:therapeutic use / Q000633:toxicity; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010789:Phototherapy; D011239:Prednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011370:Proflavine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects; D013492:Suppuration / Q000209:etiology; D014945:Wound Healing
D000166:Acridines; D001623:Betamethasone; D011239:Prednisolone; D011370:Proflavine; D007065:Idoxuridine; D011241:Prednisone