[Selective fixation of methylselenobenzoic acid by the pineal gland].
Investigation of the localization in the central nervous system of the rat of an epileptogenic agent, methylseleno-2-benzoic acid, did not lead to its selective distribution in the cerebral cortex or in the brainstem in relation with its biological activity. But a systematic study of the distribution of this compound labelled with 75Se at a high specific activity has revealed a rate of fixation by the pineal gland 4 to 5 times higher than that of other tissues of the central nervous system. After a survival time of 4 hours, the radioactivity of the pineal gland exceeds that of the blood. A parallel study of the distribution of the 75SeO3- ion on the one hand of the 35S homolog of the 75Se compound on the other hand has demonstrated that the fixation by the pineal gland is bound to the molecular structure of the selenium compound.
D000818:Animals; D001565:Benzoates / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D007700:Kinetics; D009928:Organ Specificity; D016566:Organoselenium Compounds; D010870:Pineal Gland / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D012643:Selenium / Q000378:metabolism*
D001565:Benzoates; D016566:Organoselenium Compounds; C019488:methylseleno-2-benzoic acid; D012643:Selenium
Fixation sélective de l'acide méthylsélénobenzoïque par la glande pinéale.