[Exocrine pancreatic function and calcium balance. Experimental studies of the effect of parathyroid hormone, vitamin D3, 25-hydroxycholecalciferol, dihydrotachysterin and thyrocalcitonin (author's transl)].
The effect of the acute elevation of extracellular calcium concentration, of vitamin D3, 25-hydroxycholecalciferol, dihydrotachysterin, parathyroid hormone and of thyrocalcitonin on the exocrine function of the perfused cat pancreas was studied. Elevation of the perfusate calcium concentration resulted in an initial increase in the enzyme and, occasionally, calcium concentration of the pancreatic juice, the flow rate and the secretion of magnesium and chloride were not very much altered. The application of vitamin D3 and 25-hydroxycholecalciferol elevated the stimulated (by acetylcholine or cholecystokinin-pancreocymin) protein and enzyme output (lipase, alpha-amylase). Parathyroid hormone and, especially, thyreocalcitonin inhibited the stimulated protein and enzyme secretion, volume and rate of the electrolyte secretion were not changed. In states of calcium excess the stimulated protein output was decreased by both vitamin D3 and parathyroid hormone.
D000109:Acetylcholine / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002415:Cats; D002712:Chlorides / Q000378:metabolism; D002762:Cholecalciferol / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology; D004097:Dihydrotachysterol / Q000494:pharmacology; D005260:Female; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D008049:Lipase / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010189:Pancreatic Juice / Q000378:metabolism; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D014807:Vitamin D / Q000494:pharmacology*
D002712:Chlorides; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D011506:Proteins; D014807:Vitamin D; D002762:Cholecalciferol; D002116:Calcitonin; D002766:Cholecystokinin; D008049:Lipase; D000681:Amylases; D008274:Magnesium; D000109:Acetylcholine; D004097:Dihydrotachysterol; D002118:Calcium
Exokrine Pankreasfunktion und Calciumhomöostase. Vergleichende tierexperimentelle Untersuchungen zur Wirkung von Parathormon, Vitamin D3, 25-Hydroxycholecalciferol, Dihydrotachysterin und Thyreocalcitonin