Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine.
A new high-pressure liquid chromatographic method for the clinical assay of 5-fluorouracil and 5-fluoroudexyuridine has been developed. The sensitivity and specificity of the method equals that of gas chromatography/mass spectrometric methods. The practical value of the method has been demonstrated by its application in several preliminary clinical studies of 5-fluorouracil in which plasma levels of 10(-8)-10(-6)M were readily monitored.
D002851:Chromatography, High Pressure Liquid; D005467:Floxuridine / Q000097:blood*; D005472:Fluorouracil / Q000008:administration & dosage / Q000097:blood*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007274:Injections, Intraperitoneal; D008722:Methods
D005467:Floxuridine; D005472:Fluorouracil