title: Ontogenetic study of a myelin-derived fraction with 2':3'-cyclic nucleotide 3'-phosphodydrolase activity higher than that of myelin.
abstract: A membrane fraction (SN 4), prepared from developing and mature rat forebrain by hypo-osmotic treatment of microsome (microsomal-fraction)-free myelin, appears to be closely related to the myelin-like fraction. Fraction SN 4 shows 2':3'-cyclic nucleotide 3'-phosphohydrolase activity higher than that of the parent myelin. Electrophoresis reveals a multitude of bands with the Wolfgram protein as the main component.
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D008861:Microsomes / Q000032:analysis; D009186:Myelin Sheath / Q000032:analysis* / Q000201:enzymology; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000096:biosynthesis; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D051381:Rats; D012967:Sodium Dodecyl Sulfate
chemical_list: D009419:Nerve Tissue Proteins; D012967:Sodium Dodecyl Sulfate; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases