Direct visualization of enveloped Epstein-Barr Herpesvirus in throat washing with leukocyte-transforming activity.
Mature enveloped virions belonging to the herpes class were found in a concentrated, partially purified specimen of throat washings from a patient undergoing immunosuppressive therapy for prevention of renal homograft rejection. This throat washing contained a high titer of biologically active Epstein-Barr virus and no other human herpesviruses. Epstein-Barr virions were not detected in throat washings from patients with mononucleosis that had only low titers of transforming activity.
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007165:Immunosuppression Therapy; D007244:Infectious Mononucleosis / Q000382:microbiology; D016030:Kidney Transplantation; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D010614:Pharynx / Q000382:microbiology*