[Destruction of cartilage in the adjuvants disease of the rat].
The structure of cartilage in rats with adjuvant disease was investigated lightmicroscopically and by scanning electron microscopy. Severe destruction of the cartilage with formation of lacunae only was observed in areas previously covered by pannus. However, outside the pannus differences between normal animals and animals with arthritis also were observed. In adjuvant treated animals a more fibrillar structure of the surface was seen as compared with untreated rats. This more fibrillar structure may be due to a loss of mucopolysaccharides. The severe destruction of cartilage must be related to the action of collagenase which only acts in areas with a close contact between cartilage and pannus.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006025:Glycosaminoglycans / Q000378:metabolism; D008297:Male; D003012:Microbial Collagenase; D051381:Rats; D013628:Talus
D006025:Glycosaminoglycans; D003012:Microbial Collagenase
Untersuchungen zum Knorpelabbau bei der Adjuvanskrankheit der Ratte