Demonstration of immunoglobulin G receptors induced by human cytomegalovirus.
Human cytomegalovirus induced a new immunoglobulin G receptor in human fibroblasts. The immunoglobulin G receptor was well localized in the perinuclear region at 48 h postinfection, and antiviral agents blocked its synthesis. The immunoglobulin G receptor bound immunoglobulin G of man and several other species. It may be a source of error in the performance of indirect fluorescence tests for human cytomegalovirus antibody.
D000914:Antibodies, Viral / Q000032:analysis; D001666:Binding Sites, Antibody; D002460:Cell Line; D002467:Cell Nucleus / Q000276:immunology; D002675:Child, Preschool; D003513:Cycloheximide / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology; D003587:Cytomegalovirus / Q000254:growth & development / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G; D007181:Inclusion Bodies, Viral / Q000187:drug effects; D007223:Infant; D007231:Infant, Newborn; D014779:Virus Replication
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D003561:Cytarabine; D003513:Cycloheximide