Evidence that the platelet retention factor is separate from the factor VIII-related antigen and factor VIII.
Plasmas from a pregnant patient with von Willebrand's disease and from a patient with von Willebrand's disease who is taking Premarin had elevated levels of Factor VIII-related antigen and Factor VIII activity without any improvement in their platelet retention abnormality. When these were added to the blood from nonpregnant patients with von Willebrand's disease no significant improvement in platelet retention followed. This suggests that the "retention factor" is independent of the antigenic Factor VIII-like material.
D001777:Blood Coagulation / Q000187:drug effects; D001803:Blood Transfusion; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D005169:Factor VIII / Q000032:analysis* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D012310:Ristocetin / Q000494:pharmacology; D014842:von Willebrand Diseases / Q000097:blood
D004966:Estrogens, Conjugated (USP); D007519:Isoantigens; D012310:Ristocetin; D005169:Factor VIII