Effect of chronic administration of aldosterone on bile secretion, on liver cytochrome P-450, and on red blood cell sodium content.
Male adult albino rabbits received, during a period of two weeks, a daily subcutaneous injection of aldosterone, 150 micrograms/kg body weight. Twenty-four hr after the last injection, bile was collected during two hr under anaestheia, then the liver was removed and submitted to cytochrome P-450 measurements and microscopic analyses. Red blood cell sodium content was measured before and after aldosterone treatment. In animals treated with aldosterone, compared with controls, we found: (1) a significant diminution (p less than 0.01) of bile flow rate, of sodium biliary excretion and of biliary bile acid output; (2) a significant increase (p less than 0.001) of liver cytochrome P-450; (3) hyaline modifications of hepatocytes without necrosis or steatosis; (4) a proliferation of liver smooth endoplasmic reticulum; (5) an increase (p less than 0.001) of red blood cell sodium content.
D000251:Adenosine Triphosphatases / Q000032:analysis; D000450:Aldosterone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001646:Bile / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D004790:Enzyme Induction; D004912:Erythrocytes / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D011817:Rabbits; D012636:Secretory Rate / Q000187:drug effects; D012964:Sodium / Q000097:blood*; D013997:Time Factors
D000450:Aldosterone; D003577:Cytochrome P-450 Enzyme System; D012964:Sodium; D000251:Adenosine Triphosphatases