title: Inhibition by polyhalogenated hydrocarbons (PHHC) of ATPases in plasma membranes of parenchymal liver cells.
abstract: Suspensions of freshly prepared plasma membranes from rat livers were equilibrated with defined mixtures of air with polyhalogenated hydro-carbons (PHHC) at 37 degrees C. During the exposition enzymatic degradation of ATP was inhibited by carbon tetrachloride, chloroform and halothane in a dose-dependent manner. On a molar basis carbon tetrachloride was 5 times more effective than chloroform and halothane. The inhibition was partially reversible. Diethyldithiocarbamate, an agent protecting animals against carbon tetrachloride, was ineffective in this assay.
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D002725:Chloroform / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D006846:Hydrocarbons, Halogenated / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats
chemical_list: D006846:Hydrocarbons, Halogenated; D002725:Chloroform; D004050:Ditiocarb; D002251:Carbon Tetrachloride; D000251:Adenosine Triphosphatases; D006221:Halothane