[Correlation of structural and ultrastructural modifications of the renal cortex with water, sodium and protein excretion in rats rendered hypertensive by perinephritic constriction by collodion].
Water, sodium and proteins renal excretion in with collodion Page's method hypertensive rats is compared with that of same Wistar strained control rats. Blood pressure of treated animals (n = 16) is 193.1 Hg mm (138 in control rats). Urinary flow increases from 19.5 to 33.7 ml/24 h (+ 72.8%), sodium excretion from 29.6 to 37.5 mg/24 h (+ 26.7%) and total proteins excretion from 23.5 to 63 mg/24 h (+ 169%. This data are correlated with the renal cortex morphological changes with photon and electron microscope. Severe damages are seen in Bowman's capsule and in glomerular copruscules, especially at the epithelial layer level. Important proteic pools occur within tubular lumen. Proximal tubular epithelium seems normal. On the other hand, distal tubular epithelium seriously scales. So, important water, sodium and proteins excretion increase in our experimental hypertension model can be explained. It is also discussed about functional and structural modifications analogy in our model's rats and in spontaneously hypertensive rats (SHB).
D001794:Blood Pressure; D001834:Body Water / Q000378:metabolism*; D003101:Collodion; D006977:Hypertension, Renal / Q000139:chemically induced / Q000503:physiopathology*; D007672:Kidney Cortex / Q000473:pathology* / Q000648:ultrastructure; D007684:Kidney Tubules / Q000648:ultrastructure; D011507:Proteinuria; D012964:Sodium / Q000652:urine*
D003101:Collodion; D012964:Sodium
Etude corrélative des modifications de la structure et de l'ultrastructure du cortex rénal et de l'excrétion de l'eau, du sodium et des protéines chez le rat rendu hypertendu par périnéphrite constrictrice au collodion.