Acceptor proteins in rat androgenic tissue chromatin.
Fractionation of chromatin into urea-soluble chromosomal nonhistone proteins (UP), histones (HP), and DNA-associated nonhistone proteins (NP) revealed that the NP fraction from testicular and prostatic chromatin contains organ-specific acceptors for complexes of 5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and its receptor. This acceptor capacity of androgenic tissue chromatin could be transferred to chromatins from non-target tissues with the NP fraction of DNA-associated proteins. Phosphorylation of chromatin enhanced its hormone-receptor binding capacity.
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D011467:Prostate / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface; D013737:Testis / Q000378:metabolism
D002843:Chromatin; D010710:Phosphates; D011506:Proteins; D011956:Receptors, Cell Surface; D013196:Dihydrotestosterone