title: [Clinical aspects of the anti-androgens].
abstract: The ongoing development and gradual availability of the new anti-androgens hold exciting clinical implications for the future. The biosynthesis and interchangeability of the sex steroids, the roles of the ovaries and adrenals and the value and interpretation of biochemical assays in clinical practice are briefly discussed. Because the anti-androgens are used primarily for seborrhoea/acne/hirsutism/oligomenorrhoea, the pathophysiological basis of this socially debilitating syndrome is discussed. The classification of the anti-androgens, their indications, side-effects, dosage schemes and results of treatment are reviewed. Finally, a summary of a possible clinical management regimen is presented.
mesh_terms: D015068:17-Ketosteroids / Q000032:analysis; D000152:Acne Vulgaris / Q000188:drug therapy; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy; D000726:Androgen Antagonists / Q000145:classification / Q000378:metabolism; D000728:Androgens / Q000096:biosynthesis / Q000502:physiology; D000738:Androsterone / Q000096:biosynthesis; D003278:Contraceptives, Oral, Hormonal / Q000502:physiology; D003517:Cyclopentanes / Q000494:pharmacology; D003534:Cyproterone / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D012628:Dermatitis, Seborrheic / Q000188:drug therapy; D013196:Dihydrotestosterone / Q000096:biosynthesis; D045166:Estradiol Congeners / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006628:Hirsutism / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D006914:Hydroxysteroids / Q000097:blood; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D008525:Medroxyprogesterone / Q000378:metabolism; D009277:Nandrolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011944:Receptors, Androgen / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013256:Steroids / Q000502:physiology; D013739:Testosterone / Q000097:blood
chemical_list: D015068:17-Ketosteroids; D000726:Androgen Antagonists; D000728:Androgens; D003278:Contraceptives, Oral, Hormonal; D003517:Cyclopentanes; D045166:Estradiol Congeners; D005938:Glucocorticoids; D006914:Hydroxysteroids; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin; D013256:Steroids; D013196:Dihydrotestosterone; D013739:Testosterone; D009277:Nandrolone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000738:Androsterone; D003534:Cyproterone; D008525:Medroxyprogesterone
vernacular_title: Kliniese aspekte van die anti-androgene.