Lymphocyte-differentiating hormone of bursa of fabricius.
Induction of early lymphocyte differentiation was studied in vitro in fractionated bone marrow cells of newly hatched chickens, with alloantiserums to identify newly differentiated B cells (Bu-1+) and T cells (Th-1+). Thymus extract induced selective T cell differentiation; the activity of the extract corresponds to that of thymopoietin. Bursal extract induced both B cell and T cell differentiation, but at lower concentrations B cell differentiation was always greater. This activity is ascribed to a lymphocyte-differentiating hormone of the bursa of Fabricius, for which the name bursopoietin is suggested.
D000818:Animals; D000941:Antigens / Q000032:analysis; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002060:Bursa of Fabricius / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D002645:Chickens; D000242:Cyclic AMP / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology; D013499:Surface Properties; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000941:Antigens; D006728:Hormones; D010455:Peptides; D000242:Cyclic AMP