Phospholipid-induced modifications in the brain of animals fed with cholesterol-supplemented diet.
1) Cholesterol - enriched diet induces changes in the phospholipid fatty acids of particulate fractions and modifications in the membrane-bound enzyme: 2) BC-PL (100 mg/kg i.p., as shown in rabbits) prevent cholesterol-induced modifications at brain level: 3)BC-PL (100 mg/kg i.v., as shown in mice) have a recovery effect on the cholesterol-induced modification at brain level; 4) It is suggested that some atherosclerotic lesions are analogous to those reproduced by anoxia; 5) It is suggested that the effect of BC-PL is a direct action at the level of the brain cellular membranes.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D002784:Cholesterol / Q000097:blood / Q000494:pharmacology; D002791:Cholesterol, Dietary; D000242:Cyclic AMP / Q000378:metabolism; D004036:Diet, Atherogenic; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D051379:Mice; D009929:Organ Size; D010743:Phospholipids / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology
D002791:Cholesterol, Dietary; D010743:Phospholipids; D002784:Cholesterol; D012964:Sodium; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium