title: [The effect of alloxan on the multiplication of different types of normal or cancerous cells, and on the transformation of chick embryo fibroblasts by Rous virus in vitro].
abstract: The action of alloxan was studied in vitro, on different categories of normal or cancerous cells. At concentrations of 250 and 350 gamma/ml, alloxan does not significantly inhibit the growth of normal cells, whereas it does inhibit the growth of cancerous cells. Furthermore, alloxan inhibits infection and transformation of chicken-embryo fibroblasts infected by the Rous virus.
mesh_terms: D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D001358:Avian Sarcoma Viruses; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002642:Chick Embryo; D006224:Cricetinae; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
chemical_list: D000496:Alloxan
vernacular_title: Action de l'alloxane sur la multiplication de différents types de cellules normales ou cancéreuses, et sur la transformation des fibroblastes d'embryon de poule par le virus de Rous in vitro