[Combination of chemotherapy and radiotherapy. II. Differential effect on the medullary syndrome of irradiation combined with the drug administered in fractional doses and at various times].
We have studied the effect of 5-Fu in fractional doses on the medullar syndrome after a single whole body cobalt irradiation in mice. The bone marrow is not sensitive to the fractionation of 5-Fu and it is the single dose of 5-Fu injected 72 hours after the irradiation which is the most effective.
D000818:Animals; D001855:Bone Marrow Diseases / Q000188:drug therapy* / Q000532:radiotherapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors
D005472:Fluorouracil
Association de chimiothérapie et de radiothérapie. II. Effet différentiel sur le syndrome médullaire de l'association de l'irradiation et du fractionnement dans le temps de la drogue.