[Choreic dyskinesia and GABA - pharmaco-clinical approach. Preliminary note].
The effects of Baclofen, a gabamimetic drug, have been studied in 4 patients affected by Huntington's Chorea. The biochemical bases of Chorea are discussed in relation to the HVA modifications in the cerebrospinal fluid induced by the drug. Some interesting data on the extrapyramidal physiology may be achieved with further investigations in a greater group of patients.
D000328:Adult; D000613:Aminobutyrates / Q000627:therapeutic use*; D001418:Baclofen / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D005116:Extrapyramidal Tracts / Q000503:physiopathology; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged
D000613:Aminobutyrates; D001418:Baclofen; D006719:Homovanillic Acid
Discinesie coreiche e Gaba - approccio farmaco-clinico. Nota preliminare.