Exposure to an environment containing the aromatic red cedar, Juniperus virginiana: procarcinogenic, enzyme-inducing and insecticidal effects.
(1) Shavings from the Eastern Red Cedar (Juniperus virginiana) were examined for three diverse biological properties, i.e. enzyme induction, procarcinogenicity and insecticidal activity. (2) The ability of a cedar environment to stimulate liver drug-metabolizing enzymes in mice was confirmed by lowered values for barbiturate sleeping time. (3) In susceptible strains of mice (C3H-Avy, C3H-AvyfB and CBA/J) the use of cedar shavings as bedding increased significantly the incidence of spontaneous tumors of the liver and mammary gland, and also reduced the average time at which tumors appeared. (4) Cedar and some of its derivatives (Oil of Cedarwood, cedrene, cedrol) disrupted the reproductive and developmental cycle of a number of insects, including the Peanut Trash Bug (Elasmolomus sordidus), the Indian Meal Moth (Plodia interpunctella) and the Forage Mite (Tyrophagus putrescentiae).
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D003058:Cockroaches / Q000502:physiology; D004777:Environment; D004790:Enzyme Induction; D007313:Insecta / Q000502:physiology; D008113:Liver Neoplasms / Q000209:etiology; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000209:etiology; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014934:Wood
D010424:Pentobarbital