title: Cyclic AMP in human blood platelets: relation to platelet prostaglandin synthesis induced by centrifugation or surface contact.
abstract: Exposure of blood platelets to physical stimuli such as centrifugation, filtration through Sepharose gel, or stirring with particulate material leads to production of prostaglandins E2 and F2alpha and to a reduction in cAMP. These effects resemble those produced by ADP, epinephrine, collagen, and thrombin in association with the platelet release reaction but are less  effectively inhibited by aspirin.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001665:Binding Sites; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000502:physiology; D003094:Collagen / Q000494:pharmacology; D000242:Cyclic AMP / Q000097:blood*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D011145:Polyvinyls; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000097:blood; D011460:Prostaglandins F / Q000096:biosynthesis* / Q000097:blood; D012701:Serotonin / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology
chemical_list: D011145:Polyvinyls; D011458:Prostaglandins E; D011460:Prostaglandins F; D012701:Serotonin; D000244:Adenosine Diphosphate; D003094:Collagen; D000242:Cyclic AMP; D013917:Thrombin; D001241:Aspirin; D004837:Epinephrine