[Nature of the suppressor cells blocking the activation of DNA synthesis in mixed cultures of normal lymphocytes].
The nature of suppressor cells which are contained in lymphocyte suspension of mice immunized with allogeneic tumor cells and inhibit the DNA synthesis activation in mixed normal lymphocyte cultures has been studied. The suppressor cells are shown to be resistant to mitomycin C, X-irradiation and are not inactivated by the treatment of anti-O-serum or anti-Ig-serum in the presence of the complement. They adhere to the plastic and are inactivated by carrageenan in vitro. The macrophage nature of the suppressor cells is suggested.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008937:Mitomycins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects
D000961:Antilymphocyte Serum; D008937:Mitomycins; D002351:Carrageenan; D004247:DNA
O prirode kletok-suppressorov, blokiruiushchikh aktivatsiiu sinteza DNK v smeshannykh kul'turakh normal'nykh limfotsitov.