Effects of some prostaglandins on the main phosphorylating, electron transporting and peroxidative systems of the erythrocyte membrane.
Investigations regarding the main biochemical systems of the erythrocyte membrane were performed on rat erythrocyte ghosts after treating the animals with PGA1, PGE1 and PGF2alpha. These investigations have shown that the prostaglandins which were found to induce changes in the erythrocyte flexibility (PGE1 and PGF2ALPHA) also induce significant changes in the concentrations of lipid peroxides, SH groups, proteins and nicotinamide adenine nucleotides, as well as in the activity of some electron transportors belonging to the nicotinamide proteins, in the erythrocyte membrane.
D000227:Adenine Nucleotides / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D011455:Prostaglandins A, Synthetic / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D000227:Adenine Nucleotides; D010545:Peroxides; D011455:Prostaglandins A, Synthetic; D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D011465:Prostaglandins, Synthetic; D011506:Proteins; D013438:Sulfhydryl Compounds; D005954:Glucosephosphate Dehydrogenase; D014969:Xanthine Oxidase; D000251:Adenosine Triphosphatases