The epidemiology and virology of C-type virus-associated hematological cancers and related diseases in wild mice.
In several different populations of wild mice, observed over a 35-month period in laboratory geriatric colonies, a direct correlation was found between the prevalence and titer of spleen complement-fixing gs (p30) antigen and C-type particles in newly trapped healthy mice and a predilection to lymphoma and a hind leg paralytic disease upon aging. Other studies have established the indigenous C-type virus as the essential etiological determinant of both diseases in wild mice. An increased incidence of breast carcinomas, hepatomas, and pulmonary adenomas associated with C-type virus also occurred in the lymphoma-paralysis-prone colony as compared with the tumor-resistant colonies.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology; D008113:Liver Neoplasms; D008175:Lung Neoplasms / Q000453:epidemiology; D008223:Lymphoma / Q000276:immunology / Q000382:microbiology / Q000401:mortality* / Q000473:pathology; D008325:Mammary Neoplasms, Experimental / Q000453:epidemiology; D051379:Mice; D009374:Neoplasms, Experimental / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D010243:Paralysis / Q000150:complications / Q000401:mortality*; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification; D013154:Spleen / Q000276:immunology
D000956:Antigens, Viral