[Immunovirological factors in epitheliomas of the rhinopharynx].
The epidemiology of nasopharyngeal carcinoma (NPC) suggests the intervention of genetic factors. These factors may be represented by a specific HL-A pattern (leucocyte antigens) as found in Chinese NPC patients (deficit of antigens corresponding to the second sublocus and discovery of a new antigen, named SIN-2). The association between NPC and a herpesvirus (the EBV) is based on elevated antibodies against a variety of EBV coded antigens, on cell mediated immune reactions, and on the regular presence of viral fingerprints in the epithelial tumour cells (viral DNA and nuclear antigen -- EBNA). The serological profile should help to establish the diagnosis of NPC in certain cases. The association between genetic factors, a herpesvirus and a human tumour represents a unique model in human cancer research.
D000917:Antibody Formation; D000956:Antigens, Viral; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral; D003937:Diagnosis, Differential; D006680:HLA Antigens / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007109:Immunity; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D010452:Peptide Biosynthesis; D012698:Serologic Tests; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
D000956:Antigens, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D006680:HLA Antigens; D014764:Viral Proteins
Facteurs immuno-virologiques dans les épithéliomas du rhinopharynx