title: Modification of myometrial activity in vivo by administration of cyclic nucleotides and theophylline to the pregnant rat.
abstract: Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short-term infusions of theophylline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were investigated. All three compounds caused a decrease in oxytocin-induced, prostaglandin F2alpha-induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre-infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology*; D005260:Female; D010121:Oxytocin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D011460:Prostaglandins F; D010121:Oxytocin; D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP