Action of biogenic amines injected intracerebrally on duration of hexobarbital-induced sleep in rats.
The influence of intracerebrally injected biogenic amines and cyclic AMP dibutyrate on duration of sleep induced with hexobarbital (50 mg/kg i.v.) in rats was studied. Duration of sleep was markedly prolonged by adrenaline, noradrenaline, dopamine, 5-hydroxydopamine and acetylcholine. Cyclic AMP dibutyrate injected 30 minutes before hexobarbital shortened time of sleep. The role of biogenic amines in hexobarbital-induced sleep is discussed.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000008:administration & dosage / Q000494:pharmacology*; D003994:Bucladesine / Q000008:administration & dosage / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006591:Hexobarbital; D006632:Histamine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007276:Injections, Intraventricular; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D009647:Normetanephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D014439:Tyramine / Q000494:pharmacology
D001679:Biogenic Amines; D006892:Hydroxydopamines; D009647:Normetanephrine; D012701:Serotonin; D003994:Bucladesine; D006632:Histamine; D006591:Hexobarbital; D007545:Isoproterenol; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine; D004837:Epinephrine