[Mechanism of action and kinetics of lithium. I. Biochemical and experimental pharmacological findings after administration of lithium-conclusions on the mechanism of the therapeutic effect of lithium].
A comprehensive consideration of biochemical and pharmacodynamic lithium (Li) effects enabled an explanation of the Li mechanism (Fig 1). According to this concept, Li might possibly affect the activity of membrane-bound ATPases in dependence on the initial situation, dose and duration of application. Research into Li-kinetics suggested the participation of active process in the transport of the ion through the organism. Li-kinetics describes distribution within a multiple-compartment system and, with the exception of the resorption phase, its independent of the anion used. The elimination (half-life time 22 to 25 hrs) is limited by backward flow form the tissue.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D001693:Biological Transport, Active; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012964:Sodium / Q000378:metabolism
D002395:Catecholamines; D008094:Lithium; D012964:Sodium; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases
Zum Wirkungsmechanismus und zur Kinetik von Lithium. I. Biochemische und experimentell pharmakologische Befunde nach Lithiumapplikation-Schlussfolgerungen zum Mechanismus des therapeutischen Lithiumeffektes