The influence of pinealectomy and of pinealectomy combined with thymectomy oncogenesis caused by polyoma virus in rats.
The inoculation of Polyoma virus suspension to neonatal pinealectomized rats did not provoke a growth of neoplasia. However, if the pinealectomy was combined with neonatal thymectomy, renal tumors occured in a rate of 50 of animals. An incidence of renal tumors was observed also in 57.6% of thymectomized rats, but not in non operated control group. The stimulating effect of pinealectomy on the growth of transplantable tumors has already been described several times (2, 3, 6, 8). The question of a possible change in the viral oncogenesis after pinealectomy was raised. For this reason Polyoma virus was used and its oncogenic effect was studied on the neonatally pinealectomized rats, on rats neonatally thymectomized and on neonatally pinealectomized rats which were simultaneously thymectomized.
D000818:Animals; D000831:Animals, Newborn; D002471:Cell Transformation, Neoplastic; D007680:Kidney Neoplasms / Q000209:etiology; D010870:Pineal Gland / Q000502:physiology*; D011120:Polyomavirus; D051381:Rats; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*