title: [The effect of changes in the bones of the skull due to Mediterranean anaemia on the shape of the skull and the formation of the cranial cavity (author's transl)].
abstract: The head and skull in patients with Mediterraneen anaemia show often a marked change of the external shape due mainly to the considerable enlargement of the cranial bones. From the abnormal external appearance the suspicion may arise that the form and space of the internal cranial cavity are likewise affected and even the basic structure of the skull is altered. However, a detailed investigation of the principal angles, distances and characteristic structures of the skull made on lateral roentgenograms of these patients, a comparison of the results between cases with different intensity of the osseous changes and a confrontation with the findings in normal individuals proved that there were no major discrepancies. The essential features of the human skull were always preserved. Only in some cases with severe alterations of the cranial bones a few small deviations from the normal values could be noticed and in a little number of them signs of a slight narrowing of the cranial cavity werde to be observed. This way was probably caused by a very early, rapid and extreme enlargement of the cranial bones resulting in a kind of "premature panzer-skull."
mesh_terms: D000293:Adolescent; D000328:Adult; D001846:Bone Development; D002508:Cephalometry; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012886:Skull / Q000473:pathology*; D013789:Thalassemia / Q000473:pathology*
vernacular_title: Welchen Einfluss haben die Veränderungen an den Schädelknochen bei den Mittelmeeranämien auf den Bauplan des Schädels und auf die Gestaltung der Schädelhöhle?