title: Portacaval shunt in two patients with homozygous type II hyperlipoproteinaemia.
abstract: We report the clinical and biochemical course of 2 patients who underwent portacaval shunting for the relief of homozygous type II hyperlipoproteinaemia. In our first patient, the initial favourable clinical and biochemical response subsequently deteriorated and a splenoportogram revealed the presence of a blocked splenic vein with a large collateral blood supply to the liver. The second patient has responded quite dramatically; there has been relief of her preoperative anginal attacks and a significant fall in her plasma cholesterol concentration. The present role of portacaval shunts in the management of this conditions is discussed.
mesh_terms: D002675:Child, Preschool; D003097:Collateral Circulation; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology / Q000601:surgery*; D006949:Hyperlipidemias / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery*; D007223:Infant; D008077:Lipoproteins, LDL / Q000097:blood*; D008099:Liver / Q000098:blood supply; D011167:Portacaval Shunt, Surgical; D011183:Postoperative Complications / Q000503:physiopathology; D014973:Xanthomatosis / Q000503:physiopathology / Q000601:surgery
chemical_list: D008077:Lipoproteins, LDL