["Malabsorptive" dermatitis herpetiformis. A study with particular regard to biopsy findings of the small intestine (author's transl)].
21 patients (6 females and 15 males) with Dermatitis herpetiformis have been studied with special considerations of the small intestinal biopsy-findings. During this investigation the patient's mean age was 45 years (20-68) and the mean age at onset was 38 years (17-64). In 5 patients (23.8%) total villous atrophy (group I) and in 4 patients (19.0%) a severe partial or subtotal villous trophy (group II) was found on small intestinal biopsy. The sprue-like changes were patchy lesions. Histocompatibility-antigens of type HLA-AL were found in 38.1% and of type HLA-B8 in 47.6%. After 20 years of the disease one patient died of a malignant lymphoma of the intestine (immunoblastic sarcoma). In all patients the number of interepithelial lymphocytes in the small bowel mucose was significantly increased, as it was in those patients with a normal villous pattern (group III). In a quantitative analysis of specifically labeled (peroxidase-anti-perosidase complex) IgG-, IgA- and IgM-cells in the intestinal mucosa it was found that the number of all three plasma cell classes are increased significantly (P less than 0.01).
D000328:Adult; D000368:Aged; D001284:Atrophy; D001706:Biopsy; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000473:pathology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007413:Intestinal Mucosa / Q000032:analysis; D007421:Intestine, Small / Q000473:pathology*; D008214:Lymphocytes; D008286:Malabsorption Syndromes / Q000150:complications; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Uber die "malabsorptive" Dermatitis herpetiformis Duhring. Eine katamnestsche Studie unter besonderer Berücksichtigung dünndarm-bioptischer Befunde.