Barbiturates and calcium-activated adenosine triphosphatase.
Anaesthetic barbiturates potentiate and convulsant barbiturates inhibit the calcium-activated adenosine triphosphatase (Ca-ATPase) activity in rat brain synaptosomes. Such differential effects and consequent modification of transmitter release may be important in the contrasting actions of these classes of barbiturates in vivo.
D000654:Amobarbital / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013574:Synaptosomes / Q000201:enzymology
D001463:Barbiturates; D000252:Calcium-Transporting ATPases; D000654:Amobarbital; D010424:Pentobarbital; D010634:Phenobarbital