[Effects of parenteral infusion of glycerol on glycerol kinase and adenosintriphosphate in rat kidneys (author's transl)].
Effects of intravenous glycerol infusions on glycerol kinase and adenosintriphosphate in rat kidneys. Intravenous infusions of glycerol with rates near and above the average maximal turnover capacity (0,74 g.kg-1.h-1) cause alterations of the kidneys such as weight increase, decrease of protein content and activity of glycerol kinase with excretion of this enzyme in the urine. At infusion rates of 0,6 g.kg-1.h-1 and more a decrease of the ATP-content of the kidneys is observed. Effects on the liver are not consistent and only demonstrable at infusion rates above the maximal turnover rate of glycerol. The results are discussed with regard to osmotic nephrosis. The appearance of glycerol kinase in the urine is discussed as an early symptom of kidney damage.
D000227:Adenine Nucleotides / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003920:Diabetes Mellitus / Q000139:chemically induced; D003928:Diabetic Nephropathies / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005990:Glycerol / Q000494:pharmacology*; D005991:Glycerol Kinase / Q000378:metabolism* / Q000652:urine; D007263:Infusions, Parenteral; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013311:Streptozocin; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000227:Adenine Nucleotides; D010710:Phosphates; D011506:Proteins; D013311:Streptozocin; D000255:Adenosine Triphosphate; D010770:Phosphotransferases; D005991:Glycerol Kinase; D005990:Glycerol
Auswirkungen parenteraler Glycerinzufuhr auf die Glycerokinase-Aktivität und den Adenosintriphosphatspiegel in der Niere von Ratten