[Influence of cortisone on the levels of pyruvic and lactic acids and the activity of the enzymes of gluconeogenesis in the tissues of newborn and adult animals].
There are considerable changes in the lactic and pyruvic acid contents and fructoso-1,6-diphosphatase and glucose-6-phosphatase activities in some tissues of newborn and adult guinea pigs and rabbits 24 hours after cortisone-acetate (2 mg per 100 g of body weight) injection. In the newborn animals of both species the hormone causes a decrease in the lactic and pyruvic acid concentrations and an increase in fructoso-1,6-diphosphatase activity when in the adult ones--an increase in the lactic and pyruvic acid levels and in the glucose-6-phosphatase. In the liver and kidney cortex of adult animals as compared to the newborn ones the fructoso-1,6-diphosphatase activity is significantly increased and in other tissues under study it is decreased. Certain species differences in lactic and pyruvic acid contents and in the activities of both enzymes as well as in the character of their changes under cortisone influence are found.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003348:Cortisone / Q000494:pharmacology*; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D006168:Guinea Pigs; D007672:Kidney Cortex / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009132:Muscles / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism*; D011817:Rabbits; D013154:Spleen / Q000378:metabolism
D007773:Lactates; D011773:Pyruvates; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D003348:Cortisone
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