[Immunological examination of lymphocytes in patients with sarcoidosis and bronchial asthma (author's transl)].
Blood lymphocytes of 31 patients with bronchial asthma and of 20 patients with sarcoidosis were isolated and investigated for the following surface markers: E-receptors (E-rosettes, a T cell characteristic), Fc-receptors (EA-rosette assay), C3-receptors (EAC-rosette assay), surface immunoglobulins (immuno-fluorescence technique). In addition, the reactivity against allogeneic lymphocytes was tested in mixed lymphocyte culture (MLC). MLC properties were defined by homozygous reference cells (so-called LD-typing). HLA-typing was performed simultaneously. The results, so far, indicate in both disease groups a series of remarkable alterations of the lymphatic subpopulations. A marked diminution of circulating T lymphocytes was encountered in some cases. The immunological results are discussed in relation to pathogenetic aspects of the diseases.
D001249:Asthma / Q000276:immunology*; D001665:Binding Sites; D003176:Complement C3; D006650:Histocompatibility Testing; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D012507:Sarcoidosis / Q000276:immunology*
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell
Immunologische Untersuchungen der Lymphozyten von Patienten mit Sarkoidose und Asthma bronchiale.