The effect of ionomycin on calcium fluxes in sarcoplasmic reticulum vesicles and liposomes.
Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M. The effect is due to an increase in the Ca2+ permeability of the membrane which is also observed on liposomes. The inhibition of Ca2+ uptake is accompanied by an increase in the Ca2+-sensitive ATPase activity of sarcoplasmic reticulum vesicles.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004987:Ethers / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology*; D007700:Kinetics; D008081:Liposomes; D008861:Microsomes / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010070:Oxalates / Q000378:metabolism; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*
D004987:Ethers; D007476:Ionophores; D008081:Liposomes; D010070:Oxalates; D000251:Adenosine Triphosphatases; D002118:Calcium