Endogenous cyclic adenosine monophosphate in tissues of rabbits fed an atherogenic diet.
Rabbits fed a high cholesterol diet experienced a significant increase in plasma adenosine 3,5-monophosphate (cyclic AMP), which was simultaneous with the increase in plasma cholesterol. The content of cyclic AMP in atherosclerotic lesion areas of rabbit aortic intima-media was significantly higher (0.24 picomole per microgram of DNA) than that in adjacent nonlesion areas or in aortic intima-dedia from control animals (0.09 picomole per microgram of DNA). The cyclic AMP content of heart, liver, skeletal muscle, and diaphragm showed no significant elevation in animals fed cholesterol.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001013:Aorta, Thoracic / Q000378:metabolism; D001018:Aortic Diseases / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary; D000242:Cyclic AMP / Q000097:blood / Q000378:metabolism*; D004036:Diet, Atherogenic; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D014280:Triglycerides; D002784:Cholesterol; D000242:Cyclic AMP