title: The carbohydrate composition of human apo low density lipoprotein from normal and type II hyperlipoproteinemic subjects.
abstract: The carbohydrate composition of the apoprotein from low density lipoprotein (LDL) of normal (average LDL cholesterol, 122 mg/100 ml) and type II hyperlipoproteinemic (average LDL cholesterol, 236 mg/100 ml) males was studied using gas-liquid chromatographic analysis of the methul glycoside derivatives. All samples containing detectable sinking pre-beta-lipoprotein were excluded from the study. The apo LDL from both groups of subjects contained mannose, galactose, N-acetyl-glucosamine and N-acetylneuraminic acid. Glucose and fucose were not found while trace quantities of galactosamine were detected. Although the quantities of galactose and N-acetylglycosamine were the same in the two groups, lower quantities of mannose (p less than or equal to 0.01) and N-acetylneuraminic acid (p less than or equal to 0.05) were found in the type II patients as opposed to normal subjects.
mesh_terms: D000328:Adult; D001059:Apoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002849:Chromatography, Gas; D005944:Glucosamine / Q000032:analysis; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D007294:Inositol / Q000032:analysis; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood; D008358:Mannose / Q000032:analysis; D008875:Middle Aged; D012794:Sialic Acids / Q000032:analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D001059:Apoproteins; D008077:Lipoproteins, LDL; D012794:Sialic Acids; D014280:Triglycerides; D007294:Inositol; D002784:Cholesterol; D005944:Glucosamine; D008358:Mannose