Effect of adrenal glucocorticoids on beta-lipoprotein production by resected liver.
The action of adrenal glucocorticoids on the level of liver beta-lipoprotein (LP) production was studied. Their effect was verified by studying LP synthesis and release from liver after the administration of various doses of glucocorticoids, after the administration of ACTH and in cases in which the effect of glucocorticoids was precluded by adrenalectomy (in vivo and in vitro). Adrenal glucocorticoids were found to limit triglyceride release in the form of beta-LP from the liver into the blood stream during the first 6 hours after partial hepatectomy (PHE). A direct study of beta-LP synthesis in the liver tissue showed that glucocorticoids inhibit liver lipid secretion by interfering with the process of beta-LP release by the liver rather than by influencing actual beta-LP synthesis in the liver.
D000818:Animals; D005260:Female; D006498:Hepatectomy; D006854:Hydrocortisone / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis
D008077:Lipoproteins, LDL; D014280:Triglycerides; D006854:Hydrocortisone