title: On the role of the collagen carbohydrate residues in the platelet. Collagen interaction.
abstract: It has been proposed that the platelet : collagen interaction is mediated in part by the collagen carbohydrate residues. To test this hypothesis we have oxidized monomeric and polymeric collagen with sodium periodate under conditions specifically designed to minimize destruction of periodate-susceptible bonds other than in the carbohydrate residues. Oxidation of the collagen significantly reduced its ability to interact with platelets. The extent of inhibition paralleled the extent of carbohydrate destruction. Oxidation with periodate also delayed the polymerization of the monomeric collagen, but even after polymerization the oxidized collagen failed to initiate the release reaction. These observations suggest that the collagen carbohydrate residues may be either near to or part of the site(s) on the collagen molecule required for platelet adhesion.
mesh_terms: D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D006601:Hexoses; D006801:Humans; D006901:Hydroxylysine / Q000032:analysis; D046911:Macromolecular Substances; D010504:Periodic Acid; D010973:Platelet Adhesiveness; D011108:Polymers; D012701:Serotonin / Q000378:metabolism
chemical_list: D006601:Hexoses; D046911:Macromolecular Substances; D011108:Polymers; D010504:Periodic Acid; D006901:Hydroxylysine; D012701:Serotonin; D003094:Collagen