title: Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells.
abstract: Biochemical analysis of cultured fibroblasts obtained from human subjects with the autosomal dominant disorder familial hypercholesterolemia has led to the identification of a hitherto unrecognized cell-surface receptor for serum lipoproteins. This receptor plays a critical role in the physiologic regulation of cholesterol metabolism in human cells, and its absence leads to elevation of serum-cholesterol levels and severe atheroslerosis.
mesh_terms: D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D002784:Cholesterol / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006937:Hypercholesterolemia / Q000201:enzymology / Q000235:genetics*; D066298:In Vitro Techniques; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000378:metabolism* / Q000494:pharmacology; D008079:Lipoproteins, VLDL / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases