title: [Recent results in the field of vinblastine group antitumour alkaloids. Biochemical studies].
abstract: Studies on the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configuration at C14' and C16', as well as the presence of the methoxycarbonyl group on C16' seem to play an essential role in the determination of biological activity. A new analogue, detected by its specific behaviour with tubulin, was found, in vivo, to be as active and less toxic than vinblastine.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation; D011108:Polymers; D011485:Protein Binding; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D011108:Polymers; D014404:Tubulin; D014747:Vinblastine
vernacular_title: Résultats récents dans le domaine des alcaloïdes antitumoraux du groupe de la vinblastine. Etudes biochimiques.