Effect of chronic administration of antidepressant drugs on the noradrenaline disappearance induced by FLA-63 in the rat brain.
We evaluated noradrenaline (NA) level and NA disappearance after FLA-63 in some regions of the brain of rats chronically treated with antidepressants: imipramine (IMI), amitriptyline (AMI) and danitracen (DAN). IMI (10 mg/kg sc), AMI (10 mg/kg sc) and DAN (3 mg/kg ip) were administered to rats twice daily for 10 days. Experiments with a single dose of antidepressants were carried out for comparison. Given chronically, IMI decelerated NA disappearance in the cortex after 2, 24, 48 hr but accelerated it 72 hr after the last injection; AMI did not produce any change in the brain regions examined up to 72 hr; DAN accelerated NA disappearance in the cortex and in the limbic system, whereas it effected no changes in the pons+medulla. These results indicate that: 1) the effects of chronic administration of IMI, AMI or DAN on the brain NA disappearance are different, 2) chronic administration of antidepressants produces effects not found at a single administration.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D004347:Drug Interactions; D007093:Imidazoles / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000928:Antidepressive Agents; D007093:Imidazoles; D010880:Piperidines; D000639:Amitriptyline; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D007099:Imipramine; D009638:Norepinephrine