Trypsin activation of latent collagenase from several mammalian sources.
Latent collagenase, subject to activation by trypsin, was found in culture fluids of cells and tissues from several mammalian sources. The activation requires exposure to enzymatically active trypsin and cannot be achieved by inhibited or by heat-inactivated trypsin.
D000818:Animals; D001842:Bone and Bones / Q000201:enzymology; D002417:Cattle; D005881:Gingiva / Q000201:enzymology; D006801:Humans; D008264:Macrophages / Q000201:enzymology; D003012:Microbial Collagenase / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000201:enzymology; D013583:Synovial Membrane / Q000201:enzymology; D014357:Trypsin / Q000494:pharmacology*
D014357:Trypsin; D003012:Microbial Collagenase