Flavoxate, a potent phosphodiesterase inhibitor.
The c-AMP phosphodiesterase inhibiting properties of flavoxate and of its main metabolite i.e. 3-methylflavone-8-carboxylic acid (MFCA), were assayed in vitro and compared to those of theophylline. Flavoxate and MFCA are competitive phosphodiesterase inhibitors, and are 21 and respectively 5 times more potent than theophylline. The smooth muscle relaxing activity of flavoxate possibly relies on this enzymatic mechanism.
D000818:Animals; D002417:Cattle; D005419:Flavonoids / Q000494:pharmacology*; D007700:Kinetics; D009206:Myocardium / Q000201:enzymology; D010726:Phosphodiesterase Inhibitors; D010880:Piperidines / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D005419:Flavonoids; D010726:Phosphodiesterase Inhibitors; D010880:Piperidines; D013806:Theophylline