[Experimental effect of bruneomycin on the energy metabolism of liver tissue].
The effect of an antitumor antibiotic bruneomycin on the energy metabolism in the liver tissue was studied. Four hours after the drug administration the consumption of glycogen and glucose in the liver tissue increased because of glycogenolysis activation, which was evident from increased activity of prosphorylase, phosphofructokinase, hexokinase and summation glycolytic activity. 24 and 48 hours after the antibiotic administration the balance of consumption and resynthesis of phosphate macroergs in the liver tissue impaired, which was evident from decreased levels of ATP, impairement of conjugation of the processes of oxidation due to impairement of permeability and structural integrity of the mitochondrial membranes. Further decrease in the glycogen liver levels was mainly due to suppressed resynthesis of glycogen because of destructive-necrotic processes. Simultaneously the processes of glycolytic splitting of glucose decreased which was evident from decreased activity of the enzymes and summation glycolytic activity.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects; D006593:Hexokinase / Q000378:metabolism; D006651:Histocytochemistry / Q000379:methods; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000201:enzymology; D010085:Oxidative Phosphorylation; D010732:Phosphofructokinase-1 / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D013308:Streptonigrin / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D000227:Adenine Nucleotides; D008112:Liver Glycogen; D013308:Streptonigrin; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D006005:Phosphorylases; D006593:Hexokinase; D010732:Phosphofructokinase-1
O vliianii bruneomitsina na énergeticheskiĭ metabolizm tkani pecheni v éksperimente