title: Replication of reticuloendotheliosis viruses in cell culture: chronic infection.
abstract: After an initial acute infection with cell killing, chicken or duck embryo fibroblasts infected in culture with reticuloendotheliosis viruses set up a chronic infection with no cell killing or morphological transformation. Essentially all of the chronically infected cells produced virus. The virus production was not sensitive to cytosine arabinoside or mitomycin C as was virus production in an acute infection. The chronically infected cells had a strong group-specific resistancto the c.p.e. of superinfecting reticuloendotheliosis viruses. However, they were sensitive to vesicular stomatitis virus and avian leukosis-sarcoma viruses. After double infection, single cells produced reticuloendotheliosis virus and avian leukosis-sarcoma virus.
mesh_terms: D001355:Alpharetrovirus / Q000254:growth & development; D000818:Animals; D001717:Birds; D002460:Cell Line; D002642:Chick Embryo; D002999:Clone Cells; D003561:Cytarabine / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral; D004372:Ducks; D005347:Fibroblasts; D008937:Mitomycins / Q000494:pharmacology; D009522:Newcastle disease virus / Q000254:growth & development; D001356:Reticuloendotheliosis virus / Q000254:growth & development*; D012190:Retroviridae / Q000254:growth & development*; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014762:Viral Interference; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
chemical_list: D008937:Mitomycins; D003561:Cytarabine