Effects of 13-nle-motilin on salivary, gastric, and pancreatic secretions in man.
Salivary, gastric, and pancreatic secretory responses to intravenous 13-norleucine-motilin (13-nle-motilin), a synthetic analog of motilin and biologically equivalent to the natural polypeptide, were studied in healthy volunteers. 13-nle-Motilin in doses of 100 ng/kg body wt/hr significantly stimulated gastric pepsin output, while H + secretion and serum gastrin levels remained unchanged. Enhanced pepsin secretion was not accompanied by an increase in gastric secretion of cyclic 3', 5'-adenosine monophosphate, nor did gastric mucosal levels of the cyclic nucleotide rise. A dose of 13-nle-motilin, which stimulated gastric pepsin output, did not exert any significant effect on salivary and pancreatic secretions.
D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000031:analogs & derivatives; D009646:Norleucine / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism*
D005755:Gastrins; D006728:Hormones; D010455:Peptides; D009037:Motilin; C008680:motilin, Nle(13)-; D009646:Norleucine; D000242:Cyclic AMP; D010434:Pepsin A