Biological activity of a hypobetalipoproteinemic agent.
A new -ind of pharmacologic activity called hypobetalipoproteinemia is described. Iperationally the activity consists of a marked reduction of heparin precipitating lipoproteins (beta and/or pre-beta electrophoretic mobility) in hypercholesterolemic animals with a simultaneous decrease in the heparin precipitating lipoprotein: cholesterol ratio. As determined by ultracentrifugal fractionation of the lipoproteins from hypercholesterolemic rat serum, this activity consists of both a reduction in heparin precipitating lipoproteins and an increase high density lipoproteins that are not precipitated by heparin. Changes in composition were also induced in both lipoprotein fractions. The greatest changes were observed for free and esterified cholesterol, which were markedly reduced in the heparin precipitating lipoproteins and concomitantly increased in the high density lipoproteins. The hypobetalipoproteinemic agent exhibiting this activity is 1-[p-(1'-adamantyloxy) phenyl]-piperidine (U-41792). This agent is active in hypercholesterolemic rats, mice, quail, and pigeons.
D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001952:Bridged-Ring Compounds / Q000031:analogs & derivatives*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary; D002793:Cholic Acids; D010856:Columbidae; D004036:Diet, Atherogenic; D004305:Dose-Response Relationship, Drug; D006937:Hypercholesterolemia / Q000097:blood*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D011784:Quail; D051381:Rats
D001952:Bridged-Ring Compounds; D002791:Cholesterol, Dietary; D002793:Cholic Acids; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D010880:Piperidines; C012152:U 41792; D002784:Cholesterol; D000218:Adamantane