The occurrence in a neonate of a pancreatic adenoma with nesidioblastosis in the tumor.
A newborn with persistent hypoglycemia and fixed insulin secretion unresponsive to medical management underwent 80% pancreatectomy. A 1-cm. nonencapsulated islet-cell adenoma near the tail of the pancreas was identified histologically. Islet-cell granules stained with indirect aldehyde fuchsin. Throughout the tumor, areas of nesidioblastosis were identified. The persistence of this embryologic process suggests a basic mechanism for the adenoma formation.
D007516:Adenoma, Islet Cell / Q000150:complications / Q000473:pathology*; D000293:Adolescent; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000473:pathology*