General effects of beryllium sulfate on isolated rat heart muscle mitochondrial fraction.
The effects caused by Be2+ on the properties of isolated rat heart muscle mitochondria were investigated. It has been shown that Be2+ enhances oxygen uptake by the mitochondrial fraction in the presence of oxidizable substrates. This is due to the uncoupling effect caused by Be2+ on the mitochondria, which also undergoes a swelling effect by this divalent ion that can be accounted by the retention of Be2+ by the mitochondria. The saturation of the organellae binding sites occurs when the concentration of the ion reaches a maximum of 6.2 mumoles/mg protein.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001608:Beryllium / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D008933:Mitochondrial Swelling; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
C020711:beryllium sulfate; D000251:Adenosine Triphosphatases; D001608:Beryllium