Bone marrow transplantation (1958-1978) : conditioning and graft-versus-host disease, indications in aplasias and leukemias.
Bone marrow transplantation (BMT), which stimulated great hope for treatment of aplasias and leukemias in 1958 following our first success in grafting this tissue, is, after a long period of study and development, experiencing renewed interest since it is now possible to obtain, in case of transplantation with genotypically matched sibling donors, 70% long survival (cures ?) in aplasia (under the condition that the recipient is not sensitized by previous transfusions) and in leukemia (under the condition that the recipient is transplanted in a period of remission and is not sensitized by transfusions). When the patient does not possess any genotypically matched donor, a trial of incompatible bone marrow transplantation after conditioning with antilymphocyte serum is reasonable, since we have obtained good, although unexplained, results with this method, which should be pursued. In any case, these transplants must be done in intensive care units in hemato-oncology departments.
D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D049673:History, 20th Century; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007938:Leukemia / Q000628:therapy*; D007959:Lymphocyte Culture Test, Mixed; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000266:history*
D006680:HLA Antigens