title: Effects of short chain alcohols and hydrocarbon compounds on the adenylate cyclase of the skin.
abstract: The cyclic AMP content of epidermal slices is increased by incubation with ethanol, the effect of which is dose-dependent from I to 5% concentration in the incubation media. n-Propanol and acetone are also effective at a concentration equimolar to 5% ethanol. Experimental results suggest that this effect of ethanol is due to activation of adenylate cyclase, rather than to the inactivation of cyclic AMP-phosphodiesterase.
mesh_terms: D000433:1-Propanol / Q000494:pharmacology; D000096:Acetone / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D000432:Methanol / Q000494:pharmacology; D012867:Skin / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D013552:Swine; D013806:Theophylline / Q000494:pharmacology
chemical_list: D000096:Acetone; D000431:Ethanol; D000433:1-Propanol; D013806:Theophylline; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000432:Methanol; D004837:Epinephrine