[Effect of aminazine and haloperidol on caudate inhibition of the conditioned reflex reaction of avoidance in cats].
The effect of neuroleptics on the avoidance behaviour under electric low-frequency stimulation of the caudate neucleus was studied in experiments with cats. Chlorpromazine (1 and 3 mg/kg) and haloperidol (0.5 mg/kg) were found to bring disorder in the behaviour of the animals and to intensify the inhibitory function of the caudate nucleus. Chlorpromazine proved in all respects to be a more active substance. The results obtained may be attributed to disruption of the central dopamine- and noradrenergic transmission.
D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D006220:Haloperidol; D002746:Chlorpromazine
Vliianie aminiazina i galoperidola na kaudatnoe tormozhenie uslovnoreflektornoĭ reaktsii izbeganiia u koshek