[Effects of chlorpromazine on hypertension by desinhibition in dogs: comparison of intravenous and intracisternal administration].
The tensional effects of intravenous and intracisternal chlorpromazine were studied in neurogenic hypertensive dogs by desinhibition and bilateral vagotomy. Intravenous (2-5 mg/kg) chlorpromazine corrected instantaneously the rise in blood pressure after desinhibition, but was inactive on tachycardia. Intracisternal (0.5-2 mg/kg) chlorpromazine was always inactive in the desinhibited dog. These results exclude an intervention from baro -- or chemo -- receptors and central sympathetic structures (alpha adrenergic or dopaminergic receptors). They show that the hypotensive effect of chlorpromazine is a peripheral mechanism.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier; D001921:Brain / Q000503:physiopathology; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007275:Injections, Intravenous; D008297:Male; D014628:Vagotomy
D002746:Chlorpromazine
Effets de la chlorpromazine sur l'hypertension par défrénation chez le chien : comparaison de l'administration intra-veineuse et intra-cisternale.