Transformation of horse skin cells by type-C sarcoma viruses.
A horse skin cell line (E. Derm, NBL-6, CCL-57) was susceptible to focus formation by the Kirsten mouse sarcoma virus, feline sarcoma virus (ST stain) and the MSV pseudotypes with woolly monkey, gibbon monkey, RD-114, AT-124, baboon placenta and murine xenotropic (BALB/c 3T3 and C57L/JD) type-C viruses. Foci were detected within 5 days after infection and the transformed cells continued to produce infectious virus and group-specific antigen of their respective type-C leukemia viruses. The transformation efficiency of various type-C sarcoma viruses in horse cells was also very high.
D000818:Animals; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003168:Complement Fixation Tests; D003470:Culture Media; D004285:Dogs; D017988:Gammaretrovirus / Q000276:immunology*; D000882:Haplorhini; D006736:Horses; D007106:Immune Sera; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008979:Moloney murine leukemia virus / Q000276:immunology; D010215:Papio; D012190:Retroviridae / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology*; D012867:Skin / Q000166:cytology; D014779:Virus Replication
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D003470:Culture Media; D007106:Immune Sera