[Vasogenic cerebral oedema. Changes in membrane ATPases. Correction by a phospholipid precursor (author's transl)].
In vasogenic cerebral oedema, there is progressive quantitative and qualitative impairment of mitochondrial ATPase and of Na/K/ATPase. This impairment, which reflects the intracellular component of cerebral oedema, would appear to be related to changes in the phospholipid environment of the cell membrane enzymes. CDP choline, a metabolic phospholipid precursor, is to a certain extent capable of correcting this disturbed activity and at the same time reduce oedema.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001929:Brain Edema / Q000188:drug therapy / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology* / Q000627:therapeutic use; D008928:Mitochondria / Q000201:enzymology; D010743:Phospholipids / Q000032:analysis; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
D010743:Phospholipids; D003566:Cytidine Diphosphate Choline; D012964:Sodium; D000251:Adenosine Triphosphatases; D002794:Choline; D011188:Potassium
Oedème cérébral vasogénique. Altérations des ATPases membranaires. Restauration par un précurseur des phospholipides.