title: Unusual, rod-shaped cytoplasmic inclusions (Hirano bodies) in a cerebellar hemangioblastoma.
abstract: The present study reports unusual, long, tubular, rod-shaped cytoplasmic inclusions found in the stromal cells of a cerebellar hemangioblastoma, associated with von Hippel-Lindau syndrome. These inclusions have two layers of circular, laminated filaments, and longitudinally arranged filaments; and appear similar to the so-called "Hirano bodies", which have been previously found in normal and various pathologic conditions of the brain tissue, skeletal muscle cells in myopathy, and interstitial cells of the testis. A review of previous ultrastructural studies of cerebellar hemangioblastoma shows several different types of cytoplasmic inclusions, but none are found to be identical to the present report.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000798:Angiomatosis / Q000150:complications; D002196:Capillaries / Q000648:ultrastructure; D002528:Cerebellar Neoplasms / Q000150:complications / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006394:Hemangiosarcoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D009362:Neoplasm Metastasis; D012171:Retinal Vessels / Q000473:pathology; D013577:Syndrome