title: Permissiveness of mouse, monkey and hybrid cells to encephalomyocarditis (EMC) virus.
abstract: Encephalomyocarditis (EMC) virus replicates to high titre in permissive mouse kidney (MKS) cells but poorly in monkey kidney (CV1) cells. The permissiveness of monkey-mouse hybrid cells varies according to their chromosomal content. In monkey cells, the synthesis of both single-stranded and double-stranded virus RNA is restricted; in semi-permissive hybrid clones, the double-stranded RNA is synthesized normally, whereas the synthesis of the single-stranded RNA is inhibited. Thus, it seems that more than one restrictive event is responsible for the low permissiveness of monkey cells to EMC virus.
mesh_terms: D000818:Animals; D002460:Cell Line; D002875:Chromosomes / Q000032:analysis; D004686:Encephalomyocarditis virus / Q000254:growth & development* / Q000378:metabolism; D000882:Haplorhini; D006822:Hybrid Cells; D051379:Mice; D012367:RNA, Viral / Q000096:biosynthesis; D013045:Species Specificity; D014779:Virus Replication
chemical_list: D012367:RNA, Viral