Unsuccessful trial of gene replacement in arginase deficiency.
The Shope virus following cutaneous inoculation produces skin papillomas in rabbits and induces a virus-coded arginase in the squameous epithelium of these papillomas. The only discernible effect of the virus inoculated intravenously in rabbits and other animals was a decrease of the serum arginine concentration. Intravenous injection in 3 hyperargininemic patients, however, did not influence the underlying metabolic disease.
D000592:Amino Acid Metabolism, Inborn Errors / Q000628:therapy*; D000818:Animals; D001120:Arginine / Q000097:blood; D004790:Enzyme Induction; D006801:Humans; D020162:Hyperargininemia; D007275:Injections, Intravenous; D027383:Papillomaviridae / Q000201:enzymology; D011817:Rabbits; D014412:Tumor Virus Infections / Q000201:enzymology / Q000209:etiology
D001120:Arginine