title: Sexual impotence: studies of the hypothalamic-pituitary-thyroid axis and the effect of oral thyrotropin-releasing factor.
abstract: Thyrotropin-releasing factor was given orally to 12 impotent patients in a dose of 43 mg daily for 4 weeks in a double-blind crossover technique and compared with placebo. TRF showed no beneficial effect over placebo. In these patients, thyroid function and the hypothalamic-pituitary-thyroid axis were examined by measuring T3, T4, and TSH before and after the TRF test. There were no pathological findings for patients included in this study.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D007172:Erectile Dysfunction / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013091:Spermatogenesis; D009435:Synaptic Transmission / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D013963:Thyroid Hormones; D013739:Testosterone; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin