[Oral treatment with tretinoin: andrological, trichological, ophthalmological findings and effects on acne (author's transl)].
Twelve patients (20 +/- 2 years) with acne vulgaris were treated orally with 20-30 mg/day tretinoin (vitamin A acid) over 90-300 days. Various laboratory tests were performed to rule out unwanted pharmacological side effects. Tretinoin therapy was well tolerated except for minor complaints of dryness around the mucous membranes of mouth and nose. The acne remained unchanged. All laboratory tests were unremarkable except for a significant rise of ejaculate volume. Other sperm parameters, trichological, ophthalmological as well as blood and urine analyses showed no measurable effects of tretinoin therapy.
D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000176:Acrosin / Q000378:metabolism; D000328:Adult; D001772:Blood Cell Count; D006197:Hair / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D012867:Skin / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives*
D014801:Vitamin A; D014212:Tretinoin; D000176:Acrosin
Orale Behandlung mit Tretinoin. Andrologische, trichologische, ophthalmologische Befunde und Therapieergebnisse bei Acne.