[Blood pressure and mesenteric blood flow in rats during the infusion of biogenic amines. Effect of supralethal irradiation].
The action of biogenic amines (noradrenaline, dopamine), infused at different concentration into the aorta of the urethane anesthetized control and irradiated rats for 2 min., was followed on the basis of systemic blood pressure and mesenteric blood flow. The mesenteric blood flow was measured by means of an electromagnetic flow meter. The changes observed i.e. after dopamine an increase in pressure and flow, after noradrenaline an increase in pressure and a decrease in flow with an increase after infusion had been stopped, correspond to those obtained in larger animals. In many, but not in all cases, the response is proportional to the log of the concentration of the amine infused. Irradiation with 2 kR, i.e. a dose which causes the animals to die from the gastrointestinal syndrome after 3 days, modified the response to dopamine and noradrenaline. The changes are, for noradrenaline, a greater pressure and a lower flow responses and for dopamine a greater pressure response at low and middle doses.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000528:radiation effects*; D004298:Dopamine / Q000494:pharmacology*; D007700:Kinetics; D008643:Mesentery / Q000187:drug effects / Q000528:radiation effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects / Q000528:radiation effects*
D004298:Dopamine; D009638:Norepinephrine
Pression sanguine et flux mésentérique chez le rat pendant l'infusion d'amines biogènes. Influence d'une irradiation supraléthale.