[Effect of various 2-methyl-(4'-chlorobenzoyl)-4-phenoxy)-2 propionic acid (LF 153) analogs on the respiratory activity of rat liver mitochondria].
Seven analogs of methyl-2 [chloro-4' benzoyl)-4 phenoxy]-2 propionic acid, (LF 153) have been tested for their effects on respiration and phosphorylation of rat liver mitochondria suspensions. They differ from one another by the sort of binding between both aromatic cycle as well as by the nature and position of the halogenated substitutions and alpha methylation in the propionic chain. All the compounds which have been tested acted as inhibitors of the electron transport chain and uncouplers of phosphorylations.
D000818:Animals; D011345:Fenofibrate / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D011422:Propionates; D011345:Fenofibrate
Inluence de quelques analogues structuraux de l'acide méthyl-2 [(chloro-4' benzoyl)-4 phénoxyl]-2 propionique (LF 153) sur l'activité respiratoire de mitochondries hépatiques de rat.