ACTH secretion during sleep in a patient with Nelson's syndrome.
Plasma ACTH determinations were made by radioimmunoassay, every 10 min for 8 hours during sleep in a patient with Nelson's syndrome. The plasma ACTH concentrations were relatively stable, fluctuating in a narrow range. It is strongly suggested that the pituitary tumor itself was secreting ACTH in an autonomous manner and it is concluded that a neuronally initiated program of ACTH secretion, was absent in the present patient with Nelson's syndrome.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000209:etiology / Q000378:metabolism*; D011183:Postoperative Complications; D012890:Sleep
D000324:Adrenocorticotropic Hormone