Evidence for long-lasting tumor immunity in a syngeneic rat lymphoma model: correlation of in vitro findings with in vivo observations.
Previous studies concerning the tumor-host relationship in the (C58NT)D rat tumor system indicated that some T-lymphocyte responses against tumor antigens were only transiently detectable after tumor inoculation; however, more sensitive procedures for the detection of proliferative responses in the mixed lymphocyte-tumor interaction (MLTI ) have been developed. Upon reexamination of the kinetics of this response, positive responses were detected as long as 650 days after inoculation. Cytotoxic effector cells could be generated in MLTI with lymphocytes from immune WF rats as long as 1 year after inoculation, and evidence was provided which indicated that the persistence of the responses observed in vitro correlated well with the resistance of immune rats to rechallenge with (C58NT)D tumor cells in vivo.
D000406:AKR murine leukemia virus; D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage; D007109:Immunity; D007116:Immunization, Passive; D066298:In Vitro Techniques; D007959:Lymphocyte Culture Test, Mixed; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology; D051381:Rats; D011920:Rats, Inbred WF; D013997:Time Factors; D014412:Tumor Virus Infections / Q000276:immunology
D000951:Antigens, Neoplasm