Prereplicative enzymic changes in regenerating rat liver.
After partial hepatectomy in rats, the following changes in enzymic activities were observed in the remnant liver during the prereplicative period. In the initial period of the prereplicative process, soon after removal of part of the liver, ornithine decarboxylase [EC 4.1.1.17] and IMP dehydrogenase [EC 1.2.1.14] increase. Subsequently, for entry into the S period, thymidine kinase [EC 2.7.1.75] increases simultaneously with increase in the intracellular cyclic AMP level and decrease in its phosphodiesterase [EC 3.1.4.17].
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D007292:Inosine Nucleotides; D007658:Ketone Oxidoreductases / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D051381:Rats; D013937:Thymidine Kinase / Q000378:metabolism; D013997:Time Factors
D007292:Inosine Nucleotides; D000242:Cyclic AMP; D007658:Ketone Oxidoreductases; D013937:Thymidine Kinase; D010727:Phosphoric Diester Hydrolases; D009955:Ornithine Decarboxylase