[Virucidal activity of the disinfectant "gigasept" against different enveloped and non-enveloped RNA-and DNA-viruses, pathogenic for men. I. Investigation in the suspension test (author's transl)].
"Gigasept" is a highly efficient chemical disinfectant on the basis of succine dialdehyde and form aldehyde. The virucidal capacity was assayed in the suspension test procedure with different representative RNA and DNA viruses with and without an envelope, such as polio wild virus type I, coxsackie virus type B 3, adeno virus type 3, herpes virus type ) and vaccinia virus. Parameter for disinfectant activity was the virus inactivation kinetic, i. e. interdependence of titer reduction vs. disinfectant concentration and disinfectant contact time. A "minimal disinfection" was defined as a greater than or equal to 99.9% virus inactivation. A "disinfection per definitionem" must gain a titer reduction of greater than or equal to 10(3) ID 50 and absence of virus. According to these criteria all virus strains were inactivated by Gigasept regardless of absence or presence of serum, which was tested in a concentration of 40% calf serum. Disinfection per definitionem was achieved with Gigasept concentrations of 3% after 60 min. or 5% after 30 min. except for enteroviruses. This group of viruses has to be disinfected with a 10% solution for 4 hours or with a 5% solution overnight. Gigasept, on the basis of these results, can be classified as a highly effective virucidal disinfectant. As to the hepatitis virus group however, no data so far are available. An enterovirus - disinfection procedure is recommended in hepatitis risk areas, as long as test systems for hepatitis viruses are not developed.
D000256:Adenoviridae / Q000187:drug effects; D000447:Aldehydes / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004267:DNA Viruses / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004770:Enterovirus / Q000187:drug effects; D005557:Formaldehyde / Q000494:pharmacology; D017955:Poliovirus / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects; D013386:Succinates; D014616:Vaccinia virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000447:Aldehydes; D000998:Antiviral Agents; D013386:Succinates; D005557:Formaldehyde
Die Viruzidie des Desinfektionsmittels "Gigasept" gegenüber verschiedenen humanpathogenen RNS- und DNS-Viren mit und ohne Hülle. I. Untersuchungen im Suspensionsversuch.