Antibody response of genetically susceptible and resistant chickens to cell-free and attenuated JM-V leukosis strain and its influence on early type II (Marek's) leukosis infection.
Experiments were carried out to: 1) determine the antibody response of chickens to cell-free and attenuated preparations of JMV leukosis strain, 2) determine the differences in antibody response to these antigens between susceptible (P-line) and resistant (N-line) chickens by means of serum neutralization and indirect fluorescent antibody tests, 3) investigate the influence of maternal (passive) antibody on early (day-old) JMV vaccination and 4) investigate the influence of maternal antibody in chicks naturally exposed continuously to JM virus from day-old to 8 weeks of age on the pathogenesis of Type II leudosis (Marek's) infections and oncogenesis.
D000818:Animals; D000917:Antibody Formation; D002474:Cell-Free System; D002645:Chickens / Q000276:immunology*; D003588:Cytopathogenic Effect, Viral; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000276:immunology; D008381:Herpesvirus 2, Gallid / Q000254:growth & development / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007274:Injections, Intraperitoneal; D008380:Marek Disease / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D009500:Neutralization Tests; D014422:Turkeys; D014765:Viral Vaccines / Q000008:administration & dosage; D014774:Virulence
D014765:Viral Vaccines