[Rabbit experimental glaucoma--preliminary study (author's transl)].
Induced high intraocular pressure, lasting more than one hour, is described in the rabbit. We inject simultaneously inside aqueous humor Epsilon Amino Caproic Acid 5 mg and Thrombin 20 U.S.N.I.H. units. To avoid leakage of aqueous humor we make the injection though a nou-perforating corneal preplaced loep and sight the suture to close the track when injection needle is taken out. We assume that high intraocular pressure is induced by 1% Adrenaline, 2% Pilocarpine and 1% Guanethidine solutions dropped in the eye each 5 mn, beginning 15 mn before anterior chamber injection and lasting during all the experiment. We point out this fact as a proof of the suitability of this method.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D004837:Epinephrine / Q000627:therapeutic use; D005901:Glaucoma / Q000139:chemically induced* / Q000188:drug therapy / Q000209:etiology; D006145:Guanethidine / Q000627:therapeutic use; D010862:Pilocarpine / Q000627:therapeutic use; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology*
D000614:Aminocaproates; D010862:Pilocarpine; D013917:Thrombin; D015119:Aminocaproic Acid; D004837:Epinephrine; D006145:Guanethidine
Glaucome expérimental chez le lapin. Etude préliminaire.