[Influence of hormones on the functional activity of the regenerating cortex of the enucleated adrenal in situ].
The functional activity of the regenerating cortex was studied in 90 female albino rats (150-200 g) after ablation of the right adrenal and enucleation of the left one. In the period of active growth of the regenerating tissue (10 days after operation) the functional activity of parenchymatous cells was low which is evidenced by poor content of both lipids and "ketosteroids". In parallel with reparation of the adrenal adrenocortical tissue mass the content of physiologically active substances was also restored (20 days after operation). After injection of hydrocortizone (daily dosage 2,5 mg) the growth and differentiation of the bundle-reticular zone in the regenerating area was inhibited. In the glomerular zone the reactions to lipids and "ketosteroids" were mainly similar to those in the glomerular zone of intact adrenal. After injection of ACTH (daily dosage 5 or 10 mg) during 10 days the regenerating area was functionally better developed than in the control since moderately pronounced reactions to "ketosteroids" and lipids appeared in it. Fairly high content of these substances in the regenerated cortex after 20 days of injections of ACTH (10 units) as well as presence of secondary necrobiotic changes pointed to functional overstrain of the newly formed organ.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D007664:Ketosteroids / Q000378:metabolism; D050356:Lipid Metabolism; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D013997:Time Factors
D007664:Ketosteroids; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
K voprosu o vozdeĭstvii gormonov na funktsional'nuiu aktivnost' regeneriruiushcheĭ kory énukleirovannogo nadpochechnika in situ