title: Inhibition of Charonia lampas ascorbate-2-sulfate sulfohydrolase activity by adenosine 5'-diphosphate and related compounds.
abstract: 1) ADP was a potent inhibitor of the ascorbic-2-sulfate sulfohydrolase activity of Charonia lampas liver.  The inhibition was competitive with respect to ascorbate 2-sulfate.  The Ki value was 5.9 muM.  ADP did not inhibit arylsulfatase (EC 3.1.6.1) of the same organism.  2) Other nucleoside 5'-diphosphates and GTP showed similar inhibition of ascorbate-2-sulfate sulfohydrolase activity.  3) The effects of different nucleosides, nucleotides, and sugar phosphates on ascorbate-2-sulfate sulfohydrolase activity were investigated.  Phosphate derivatives other than 3',5'-cyclic AMP were more or less inhibitory.
mesh_terms: D000244:Adenosine Diphosphate; D001192:Arylsulfatases / Q000037:antagonists & inhibitors*; D001205:Ascorbic Acid; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002621:Chemistry; D000242:Cyclic AMP; D006160:Guanosine Triphosphate; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008722:Methods; D008974:Mollusca; D009705:Nucleosides; D009711:Nucleotides; D010724:Phosphoadenosine Phosphosulfate; D013403:Sugar Phosphates; D013429:Sulfatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013462:Sulfur Radioisotopes
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D013403:Sugar Phosphates; D013462:Sulfur Radioisotopes; D010724:Phosphoadenosine Phosphosulfate; D000244:Adenosine Diphosphate; D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D013429:Sulfatases; D001192:Arylsulfatases; D001205:Ascorbic Acid