title: Adenylate cyclase and ATPase activities in red cell membranes of patients and genetic carriers of Duchenne muscular dystrophy.
abstract: Basal adenylate cyclase activity was increased in red cell ghosts from both patients with Duchenne muscular dystrophy and their mothers when the activities were compared to proper age-matched controls. The activity of ATPase measured in the presence of Na+, K+, and Mg2+ was not found to be different in erythrocyte ghosts from Duchenne dystrophic patients, age-matched controls, or the mothers of Duchenne patients, and ouabain inhibited ATPase in ghosts to the same extent in all membrane preparations.
mesh_terms: D000251:Adenosine Triphosphatases / Q000097:blood*; D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D002648:Child; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
chemical_list: D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D000262:Adenylyl Cyclases; D008274:Magnesium; D011188:Potassium