title: Stimulation of water and sodium secretion and inhibition of glucose absorption from the rat jejunum during intraarterial infusions of prostglandins.
abstract: The effect of prostaglandins, isoprenaline and dibutyryl cyclic adenosine monophosphate (dibut cAMP) on the net transfer of water and Na+ and glucose absorption have been studied in the anaesthetized rat. The lumen of the jejunum was recirculated with a solution of normal saline containing D (+) glucose and phenosulphonphthalein. The superior mesenteric artery was perfused extracorporeally and drugs were infused into the arterial blood. Prostaglandin E1 (PGE1) at infusion rates of 2-5 X 10(-9) and 10(-8) mol/min induced a net secretion of water and Na+ which was significantly different from the infused control mean. Both water and Na+ secretion were dose-related. PGE1 induced slight but significant inhibition of glucose absorption at 10(-8) mol/min. This could either be a direct effect or secondary to solvent drag. PGE2 (2-5 X 10(-9) mol/min) and PGF2alpha (8 X 10(-9) mol/min) induced water and Na+ secretion, and inhibited glucose absorption but not significantly. Isoprenaline (10(-9) mol/min) and dibut cAMP (8 X 10(-9) mol/min) did not alter water, Na+ or glucose absorption.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D003994:Bucladesine / Q000494:pharmacology; D004768:Enterotoxins / Q000494:pharmacology; D005947:Glucose / Q000032:analysis / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007583:Jejunum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010477:Perfusion / Q000379:methods; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D004768:Enterotoxins; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D014867:Water; D003994:Bucladesine; D012964:Sodium; D005947:Glucose; D007545:Isoproterenol