Oat cell carcinoma as a malignant apudoma.
The neural crest origin of cells secreting amine and polypeptide hormones (APUD cells) is a unifying concept. The relationship of the classical endocrine system to that of tumor hormone secretion can be explained by the diffuse migration and later neoplasia of these unique cells. This paper describes the APUD cell origins of oat cell carcinoma.
D003528:Carcinoma, Adenoid Cystic / Q000196:embryology; D018288:Carcinoma, Small Cell / Q000145:classification* / Q000196:embryology / Q000473:pathology; D006801:Humans; D007223:Infant; D008168:Lung / Q000196:embryology / Q000473:pathology / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000145:classification* / Q000196:embryology / Q000473:pathology; D009384:Paraneoplastic Endocrine Syndromes; D011379:Prognosis