A cytochemical study of some enzyme activities in biliverdin-treated cell cultures.
The authors studied the modifications of the activities of some enzymes in cell cultures submitted to the action of biliverdin. This biliary pigment rapidly induces a remarkable increase in alkaline phosphatase and ATP-ase activities and subsequently, an activation of acid phosphatase and beta-glucuronidase. On the contrary, 5'-nucleotidase and glucose-6-phosphatase activities remain unchanged. These results are discussed and compared with those obtained in our and other laboratories by using unconjugated bilirubin on different biological substrates.
D000135:Acid Phosphatase / Q000032:analysis; D000251:Adenosine Triphosphatases / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D001663:Bilirubin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured / Q000201:enzymology*; D005952:Glucose-6-Phosphatase / Q000032:analysis; D005966:Glucuronidase / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007822:Laryngeal Neoplasms; D008247:Lysosomes / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D009708:Nucleotidases / Q000032:analysis; D013268:Stimulation, Chemical
D009708:Nucleotidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase; D005966:Glucuronidase; D000251:Adenosine Triphosphatases; D001663:Bilirubin