[Effects of chloramphenicol and thiamphenicol on sleep of the mouse].
The oral administration of 0.25-2.0 g/kg of chloramphenicol at 9h selectively suppresses paradoxical sleep in mice for a duration of 2-4 hours. A dose of 1 g/kg given at 17h suppresses paradoxical sleep for 7 hours. Slow wave sleep decreased for 2 hours after administration. Thiamphenicol (1 g/kg) has no effect under the same conditions.
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000139:chemically induced; D012895:Sleep, REM / Q000187:drug effects; D013839:Thiamphenicol / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D013839:Thiamphenicol
Effets du chloramphénicol et du thiamphénicol sur le sommeil de la souris