Levamisole treatment of inflammatory acne. Restoration of impaired T-cell function accompanied by clearing of the lesions.
Serum hemolytic complement activity and its components C3, C4 and C1q, serum immunoglobulins A, M and G and peripheral E-rosette forming cells were determined in 11 patients with inflammatory acne. IgG levels were increased and the E-rosette formation was markedly impaired. Levamisole treatment restored the E-rosette formation and improved or cured the inflammatory lesions in 10 out of 11 patients.
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000276:immunology; D000293:Adolescent; D000328:Adult; D003172:Complement C1 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects*
D003172:Complement C1; D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007978:Levamisole