Radiation effects on alkaline phosphatase and glucose-6-phosphatase in anatomically different regions of mouse intestine.
The effect of gamma irradiation on alkaline phosphatase and glucose-6-phosphate has been studied in three anatomically different regions of the small intestine at a surface dose of 400 R. Both the enzymatic activities were shown to be enhanced in duodenum, jejunum and ileum 24 hours after irradiation. The activity of alkaline phosphatase on day 3 tendeed to be low as compared to day 1 post irradiation, but glucose-6-phosphatase continued to rise even after day 3. Maximum rise of glucose-6-phosphatase was observed in the jejunum. On day 9, alkaline phosphatase was diminished below the controls in the whole of intestine, but appeared to be normal on day 10. Glucose-6-phosphatase in duodenum and jejunum on the other hand was comparable to that of control mice; but in ileum, the activity of this enzyme was below the normal values. Physiological significances of these enzymes in intestine has been discussed.
D000469:Alkaline Phosphatase / Q000502:physiology / Q000528:radiation effects*; D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology; D005947:Glucose / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000502:physiology / Q000528:radiation effects*; D007082:Ileum / Q000201:enzymology / Q000528:radiation effects; D007421:Intestine, Small / Q000201:enzymology / Q000528:radiation effects*; D007583:Jejunum / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D051379:Mice; D011830:Radiation Effects; D013997:Time Factors
D000469:Alkaline Phosphatase; D005952:Glucose-6-Phosphatase; D005947:Glucose