[A transplantable myeloid hamster leukemia with high peripheral leukocyte counts and C-particles. II. Histology and cytochemistry (author's transl)].
Results on morphologic and hematologic characterization of a hamster leukemia capable of both cellular and cellfree transmission are described. Solid tumors removed in the course of several passages of leukemia animals, after producing blood smears, and spleen, liver, lymph nodes, bone marrow, thymus, kidney and lung were investigated histologically and histochemically. The morphological picture of the hamster leukemia has not changed during several transplantation generations. In addition to solid tumours, typical leukemic infiltration were detected histologically in spleen, liver, lymph nodes, bone marrow, kidneys and lung. No leukemic proliferation was noticed in the thymus. The final stage of the disease is characterized by an abrupt occurrence of high leukemic cell counts. The demonstration of alkaline phosphatase, but especially of naphtol-AS-D-chloroacetate esterase, in the leukemic cells is interpreted as indicating malignization of cells of the granulocytic line.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002474:Cell-Free System; D006224:Cricetinae; D004950:Esterases / Q000097:blood; D007942:Leukemia, Experimental / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000201:enzymology; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D009368:Neoplasm Transplantation; D012190:Retroviridae; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D013997:Time Factors; D014184:Transplantation, Homologous
D004950:Esterases; D000469:Alkaline Phosphatase
Uber eine transplantable, myeloische Hamsterleukämie mit hohen peripheren Blutwerten und C-Partikel-Befund II. Histologie und Zytochemie