[Restoration of the automatic contractile activity of K+-arrested heart muscle cells in culture by means of dibutyryl-3', 5'-adenosine monophosphate].
Cultured myocardial cells of new-born rats which were arrested by 17.6-37.6 mM KCl regained their ability to contract spontaneously after perfusion with 8-10(-4)-4-10(-3) M dibutyryl cyclic AMP. This adrenaline-like action of DbcAMP is compatible with the notion that cyclic AMP is involved as a second messenger in the action of cyclic AMP-raising adrenergic agents on cardiac activity.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D006323:Heart Arrest; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats
D003994:Bucladesine; D011189:Potassium Chloride
Wiederherstellung der automatischen kontraktilen Tätigkeit K+-gelähmter Herzmuskelzellen in Kultur durch Dibutyryl-3', 5'-adenosinmonophosphat