Watery diarrhea associated with pancreatic islet cell carcinoma.
A patient with severe watery diarrhea and a non-beta islet cell carcinoma of the pancreas producing five hormones (secretin, serotonin, enteroglucagon, vasoactive intestinal polypeptide, and pancreatic glucagon) is described. We have demonstrated massive pancreatic hypersecretion to be a major factor in this patient's diarrhea. Possible inter-relationships of the actions of five hormones present in excess in the patient are discussed.
D007516:Adenoma, Islet Cell / Q000097:blood / Q000150:complications* / Q000473:pathology; D000818:Animals; D001344:Autopsy; D001639:Bicarbonates / Q000378:metabolism; D002415:Cats; D003967:Diarrhea / Q000209:etiology*; D004386:Duodenum / Q000378:metabolism; D004848:Epithelium / Q000473:pathology; D005243:Feces; D005753:Gastric Mucosa / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D010455:Peptides / Q000378:metabolism; D012633:Secretin / Q000096:biosynthesis / Q000097:blood; D012701:Serotonin / Q000096:biosynthesis
D001639:Bicarbonates; D010455:Peptides; D012633:Secretin; D012701:Serotonin; D005934:Glucagon