title: Congenital malformations. Cleft palate, congenital heart disease, absent tibiae, and polydactyly.
abstract: A girl had cleft palate, micrognathia, Wormian bones, congenital heart disease, dislocated hips, absent tibiae, bowed fibulae, preaxial polydactyly of the feet, and abnormal dermal patterns at birth. She was born after a pregnancy complicated by exposure to multiple medications. This combination of malformations may represent a distinct entity unrelated to the medication or may be a complication of the intrauterine drug exposure.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D002700:Chloramines / Q000009:adverse effects; D002746:Chlorpromazine / Q000009:adverse effects; D002972:Cleft Palate / Q000139:chemically induced; D004157:Diphenoxylate / Q000009:adverse effects; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008844:Micrognathism / Q000139:chemically induced; D009087:Mucopolysaccharidosis VI / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011346:Prochlorperazine / Q000009:adverse effects; D011596:Psychomotor Disorders / Q000139:chemically induced; D014815:Vitamins / Q000009:adverse effects
chemical_list: D002700:Chloramines; D004966:Estrogens, Conjugated (USP); D014815:Vitamins; D004157:Diphenoxylate; D002746:Chlorpromazine; D011346:Prochlorperazine