title: Depolymerization of brain microtubules by skeletal muscle myosin.
abstract: Brain microtubules are found to disperse rods of skeletal muscle myosin and become decorated with amorphous aggregates of myosin. Then microtubules are partially depolymerized by myosin. Myosin shows high Mg2+-GTPase activity which is not influenced by microtubules, and induces the partial depolymerization of microtubules by exhaustion of GTP in the solution. H-meromyosin depolymerizes microtubules like myosin does. H-meromyosin is, however, contaminated with a trace amount of trypsin, which irreversibly depolymerizes microtubules.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001921:Brain; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D046911:Macromolecular Substances; D008870:Microtubules / Q000378:metabolism*; D009132:Muscles; D015879:Myosin Subfragments / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D011817:Rabbits; D013552:Swine; D014357:Trypsin / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances; D015879:Myosin Subfragments; D014404:Tubulin; D006160:Guanosine Triphosphate; D000469:Alkaline Phosphatase; D014357:Trypsin; D000251:Adenosine Triphosphatases; D020558:GTP Phosphohydrolases; D009218:Myosins