Inhibition of cyclic 3',5'-nucleotide phosphodiesterase-a possible mechanism of action of bifunctional alkylating agents.
D000477:Alkylating Agents / Q000494:pharmacology*; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D002279:Carcinoma 256, Walker / Q000032:analysis; D002417:Cattle; D002478:Cells, Cultured; D002699:Chlorambucil / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases / Q000032:analysis; D051381:Rats
D000477:Alkylating Agents; D010726:Phosphodiesterase Inhibitors; D002699:Chlorambucil; D000628:Aminophylline; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases