Parthenogenic origin of benign ovarian teratomas.
To determine the origin of benign cystic teratomas of the ovary, chromosome-banding studies were done on normal tissues and teratomas from five patients. The normal tissues were heterozygous (+/-) for 17 chromosome polymorphisms at or near the centromere, whereas the teratomas were uniformly homozygous (+/+ or -/-). These findings and those employing electrophoretic variants indicate that ovarian teratomas are parthenogenic tumors that arise from a single germ cell after the first meiotic division.
D000619:Aminohydrolases / Q000378:metabolism; D002478:Cells, Cultured; D002875:Chromosomes; D003884:Dermoid Cyst / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D004586:Electrophoresis; D005260:Female; D005854:Germ Cells; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007621:Karyotyping; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008540:Meiosis; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D010312:Parthenogenesis; D010430:Pentosyltransferases / Q000378:metabolism; D010733:Phosphoglucomutase / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism; D011110:Polymorphism, Genetic
D007770:L-Lactate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D010430:Pentosyltransferases; D010770:Phosphotransferases; D000619:Aminohydrolases; D010733:Phosphoglucomutase