Synthesis and electron spin resonance study of spin-labelled compounds related to tumour-growth inhibitory nitroarylaziridines.
Three stable free radicals have been prepared which are akin to 5-aziridino-2,4-dinitrobenzamide (CB 1954); these compounds all contain a nitroxide function. The metabolism and excretion of two such compounds in mice has been monitored by electron spin resonance (ESR) spectroscopy and compared with that of the simpler nitroxide, 4-keto-2,2,6,6-tetramethylpiperidino-1-oxyl (tempone).
D000818:Animals; D001388:Aziridines / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D001389:Azirines / Q000494:pharmacology*; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D004578:Electron Spin Resonance Spectroscopy; D051379:Mice; D014216:Triacetoneamine-N-Oxyl / Q000494:pharmacology
D001388:Aziridines; D001389:Azirines; D014216:Triacetoneamine-N-Oxyl