Adenylate cyclase and ATPase activities in red cell membranes of patients and genetic carriers of Duchenne muscular dystrophy.
Basal adenylate cyclase activity was increased in red cell ghosts from both patients with Duchenne muscular dystrophy and their mothers when the activities were compared to proper age-matched controls. The activity of ATPase measured in the presence of Na+, K+, and Mg2+ was not found to be different in erythrocyte ghosts from Duchenne dystrophic patients, age-matched controls, or the mothers of Duchenne patients, and ouabain inhibited ATPase in ghosts to the same extent in all membrane preparations.
D000251:Adenosine Triphosphatases / Q000097:blood*; D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D002648:Child; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D000262:Adenylyl Cyclases; D008274:Magnesium; D011188:Potassium