Epstein-Barr virus: experimental infection of Callithrix jacchus marmosets.
Eight common marmoset monkeys (Callithrix jacchus) were inoculated with about 10(4) transforming units of B95-8 virus; seven of the marmosets died 50-111 days post inoculation and all seven showed microscopic and/or macroscopic lesions compatible with a diagnosis of lymphoproliferative disease. Low levels of anti-VCA antibodies were detected in plasma from six marmosets. Attempts failed to establish continuous EBV-carrying lymphoblastoid cell cultures by cultivation in vitro of circulating lymphocytes or minced lymphoid tissues obtained at necropsy.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002143:Callitrichinae; D002213:Capsid / Q000276:immunology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D000882:Haplorhini; D004854:Herpesvirus 4, Human / Q000276:immunology*; D007942:Leukemia, Experimental / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D008199:Lymphadenitis / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D013163:Splenomegaly / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
D000914:Antibodies, Viral; D000956:Antigens, Viral