Hereditary demyelinating neuropathy in the trembler mouse.
The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.
D000200:Action Potentials; D000818:Animals; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003711:Demyelinating Diseases / Q000473:pathology* / Q000503:physiopathology / Q000662:veterinary; D051379:Mice; D009132:Muscles / Q000503:physiopathology; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000473:pathology* / Q000503:physiopathology / Q000662:veterinary; D011930:Reaction Time