title: Vascular and neuroglial changes in experimental herpes simplex encephalitis enzyme histochemical study.
abstract: An enzyme histochemical study of experimental herpes simplex encephalitis of the mouse has revealed a decrease in the number of capillaries displaying alkaline phosphatase activity. Glial cells showed increased Inosine 5 diphosphatase and ATPase activity. These enzyme histochemical changes were distributed throughout the nervous parenchyma while the lesions, seen by light microscopy, are localized to well defined areas. Mice inoculated with a pure culture of irradiated HSV failed to show the above mentioned modifications.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply; D002196:Capillaries / Q000201:enzymology; D004671:Encephalitis, Arbovirus / Q000201:enzymology* / Q000473:pathology; D006561:Herpes Simplex / Q000201:enzymology* / Q000473:pathology; D006651:Histocytochemistry; D051379:Mice; D009457:Neuroglia / Q000201:enzymology* / Q000473:pathology; D011830:Radiation Effects; D018139:Simplexvirus / Q000528:radiation effects
chemical_list: D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases