[Research on substances with antiviral activity. II. Derivatives of N-substituted 2-chloro-3-formylindoles].
Thiosemicarbazones and amidinohydrazones of N-substituted 2-chloroindole-3-aldehydes were synthesized and investigated for antiviral activity against RNA virus (parainfluenza type 3, HA-I/CR-8 stock) and DNA virus (vaccinia virus, HID stock). The thiosemicarbazones of 1-(o,m,p,-chlorobenzoyl)-2-chloroindole-3-aldehydes were more active than methisazone against vaccinia virus.
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004267:DNA Viruses / Q000187:drug effects*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D012328:RNA Viruses / Q000187:drug effects*; D018108:Respirovirus / Q000187:drug effects*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects*
D000578:Amidines; D000998:Antiviral Agents; D006835:Hydrazones; D007211:Indoles; D013882:Thiosemicarbazones
Ricerche su sostanze ad attività antivirale. II.- Derivati di 2-cloro-3-formilindoli N-sostituiti