Hydroxyamino compounds produced by the oxidation of diamines with diamine oxidase in the presence of alcohol dehydrogenase.
When the diamines putrescine, cadaverine, cystamine and lanthionamine are oxidized by purified pig kidney diamine oxidase in the presence of NADH and either liver or yeast crystalline alcohol dehydrogenase, NADH is oxidized. Chromatographic evidence obtained in the case of putrescine and cystamine indicates the production of the respective hydroxy-amino compound. In the case of cystamine, the product of the reaction is mercapto-ethanol-cysteamine mixed disulfide which may represent a biological source for the production of mercaptoethanol used for other reactions.
D000429:Alcohol Oxidoreductases; D000447:Aldehydes; D006631:Amine Oxidase (Copper-Containing); D000818:Animals; D000440:Butanols; D002103:Cadaverine; D055598:Chemical Phenomena; D002621:Chemistry; D003538:Cystamine; D003959:Diamines; D066298:In Vitro Techniques; D008623:Mercaptoethanol; D009243:NAD; D010084:Oxidation-Reduction; D011700:Putrescine
D000447:Aldehydes; D000440:Butanols; D003959:Diamines; D009243:NAD; D008623:Mercaptoethanol; D000429:Alcohol Oxidoreductases; D006631:Amine Oxidase (Copper-Containing); D002103:Cadaverine; D003538:Cystamine; D011700:Putrescine