The renin and iso-renin-angiotensin system in rats with experimental pitutary tumors (38585).
Renin, iso-renin, angiotensin I. angiotensin-converting enzyme, and angiotensinases were measured in plasma and in various extrarenal tissues of rats. Despite complete suppression of plasma renin in rats bearing pituitary tumors iso-renin and all other components of the renin-angiotensin system were found to be at or above control concentrations. The results strongly suggest that there is local synthesis of iso-renin in extrarenal tissues.
D000311:Adrenal Glands / Q000201:enzymology; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology; D010450:Endopeptidases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000201:enzymology*; D051381:Rats; D012083:Renin / Q000378:metabolism*; D000092502:Renin Inhibitors
D000804:Angiotensin II; D010450:Endopeptidases; D007703:Peptidyl-Dipeptidase A; D012083:Renin; D000092502:Renin Inhibitors