[Studies on the influence of anticoagulants on metastase formation of autochthonic hepatomas in the rat (author's transl)].
The frequency of metastases of malignant diethylnitrosamine-induced hepatomas and haemangioendotheliomas of the liver of female Sprague-Dawley rats (29%) was not influenced by application of acetyl-salicylic acid or phenprocoumon. Likewise the anticoagulants did not alter tumor yields and induction periods.
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000188:drug therapy*; D003374:Coumarins / Q000627:therapeutic use*; D004052:Diethylnitrosamine; D005260:Female; D006390:Hemangioendothelioma / Q000139:chemically induced / Q000188:drug therapy; D008113:Liver Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D010644:Phenprocoumon / Q000627:therapeutic use*; D051381:Rats
D000925:Anticoagulants; D003374:Coumarins; D004052:Diethylnitrosamine; D010644:Phenprocoumon; D001241:Aspirin
Versuche zur Beeinflussung der Metastasierung autochthoner Hepatome bei Ratten mit Antikoagulantien