The influence of parathyroid hormone and calcitonin on plasma levels of adenosine 3'5' monophosphate and electrolytes in normal and anephric subjects.
The purpose of this study was to estimate whether target tissues other than the kidney are responsive to parathyroid hormone (PTH) and calcitonin (CT) in anephric man. Twenty subjects were studied: 12 normal, 4 anephric, 4 anuric ('anephric') individuals. PTH infused into 6 normal subjects produced several fold increase in plasma level of cAMP, whereas CT caused minimal increase in the same number of normal individuals. In 4 anephrics PTH infusion resulted in a delayed rise of plasma cAMP. CT administration to 4 'anephrics' did not change plasma cAMP. In all subjects PTH and CT failed to modify plasma electrolytes level. The data indicate that the kidneys are the main source of cAMP after PTH administration and in anephric subjects extrarenal tissues are the source of circulating cAMP.
D000328:Adult; D002116:Calcitonin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000097:blood*; D004573:Electrolytes / Q000097:blood*; D006801:Humans; D009392:Nephrectomy; D010281:Parathyroid Hormone / Q000494:pharmacology*
D004573:Electrolytes; D010281:Parathyroid Hormone; D002116:Calcitonin; D000242:Cyclic AMP