[Effect of thymosterin A on the immunological reaction of mice].
Proliferaiton of thymus-dependent lymphocytes and immunological reaction of the line CBA mice immunized with sheep erythrocytes was studied as affected by thymosterol A. The data obtained confirmed the authors' assumptions on a stimulation effect of thymosterol A on division of thymocytes. Introduction of the mentioned preparation against a background of the antigenic aciton of sheep erythrocytes causes an increase in the amount of cells synthesizing hemolysins more than by 60% as compared to the control. The preparation effect depends on the dose. The data are presented, which makes it possible to assume that the mentioned effects may be due to the action of thymosterol A on the content and activity of the intracellular cyclic AMP.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002452:Cell Count; D000242:Cyclic AMP / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D013949:Thymus Extracts / Q000494:pharmacology*; D014316:Tritium
D013949:Thymus Extracts; D014316:Tritium; C010796:thymosterin; D013806:Theophylline; D000242:Cyclic AMP; D013936:Thymidine
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