Impairment of antigen-presenting cell function by ultraviolet radiation.
UV light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of UV-treated donors could not induce hapten-specific delayed hypersensitivity responses in UV-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cells from normal mice were able to do so. The failure to induce immunity in UV-treated mice by utilizing UV-treated adherent antigen-presenting cells was associated with the development of antigen-specific suppressor T cells. The implication of these results for UV-induced carcinogenesis is discussed.
D000818:Animals; D000941:Antigens; D002448:Cell Adhesion; D003877:Dermatitis, Contact / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance / Q000528:radiation effects*; D007111:Immunity, Cellular / Q000528:radiation effects*; D007116:Immunization, Passive; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology; D014466:Ultraviolet Rays
D000941:Antigens; D014301:Trinitrobenzenes