Investigations upon adenohypophysial cell proliferation in vitro: influence of oestradiol, thyrotropin releasing hormone, dibutyryl cyclic AMP and theophylline.
Mitotic indices were counted in adenohypophysial fragments cultured in vitromthe cultures exposed to 17-beta oestradiol, synthetic thyrotropin releasing hormone (TRH) and dibutyryl cyclic AMP showed a higher number of mitoses as compared with respective controls. However, theophylline decreased the mitotic index in cultured adenohypophysis.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008940:Mitotic Index / Q000187:drug effects; D010902:Pituitary Gland / Q000254:growth & development*; D010903:Pituitary Gland, Anterior / Q000254:growth & development*; D051381:Rats; D012737:Sex Factors; D013806:Theophylline / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D003994:Bucladesine; D013806:Theophylline