title: Operator-constitutive mutants in the threonine operon of Escherichia coli K-12.
abstract: Three Escherichia coli K-12 mutant strains resistant to DL-alpha-amino-beta-hydroxyvaleric acid were isolated in which the expression of the thr operon is constitutive. The localization and dominance properties of the mutations involved, called thrO, are those of operator mutations. The gene sequence is OABC as suggested by earlier studies.
mesh_terms: D001222:Aspartate Kinase / Q000378:metabolism; D002474:Cell-Free System; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D006714:Homoserine; D006715:Homoserine Dehydrogenase / Q000378:metabolism; D008190:Lyases / Q000378:metabolism; D009154:Mutation; D009876:Operon; D010770:Phosphotransferases / Q000378:metabolism; D013912:Threonine / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000494:pharmacology; D013913:Threonine Dehydratase / Q000378:metabolism; D014161:Transduction, Genetic
chemical_list: D013912:Threonine; D006714:Homoserine; D006715:Homoserine Dehydrogenase; D010770:Phosphotransferases; D001222:Aspartate Kinase; D008190:Lyases; D013913:Threonine Dehydratase