A case of xanthomatosis and hyperlipoproteinemia type V propably induced by overdosage of insulin.
A woman, aged 46 years, with a hyperlipoproteinemia phenotype V, an unusual type of xanthomatosis, as well as lipemia retinalis, diabetes mellitus, and nephropathia, is discussed. The withdrawal of 64 IU insulin and the institution of a hypocaloric diabetes diet resulted in the disappearance of the skin lesions and a regression of the eye lesion. During this treatment the total lipid-level became almost normal (6,965 mg% before treatment and 947 mg% after 10 weeks). The chylomicrons disappeared but the VLDL content remained relatively and absolutely elevated, as in type IV hyperlipoproteinemia.
D002914:Chylomicrons / Q000097:blood; D003920:Diabetes Mellitus / Q000188:drug therapy; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced*; D007328:Insulin / Q000009:adverse effects* / Q000627:therapeutic use; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D012164:Retinal Diseases / Q000139:chemically induced / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology; D013261:Sterols / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014973:Xanthomatosis / Q000097:blood / Q000139:chemically induced* / Q000473:pathology
D002914:Chylomicrons; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D013261:Sterols; D014280:Triglycerides