Experimentally induced malakoplakia.
Malakoplakia was induced experimentally by introducing large amounts of crude endotoxin-antigen comples of 075 Escherichia coli (E. coli 12797 CDC 0 group 75) into the kidneys and testes of rats. First leukocytes, then granulation tissue composed mainly of characteristic macrophages, the so-called Hansemann cells, appeared around the endotoxin-antigen mass. On the eighth day following the injection, deposition of calcium phosphate into the cytosegresomes of macrophages began and acused the formation of the Michaelis-Gutmann bodies necessary for the diagnosis of malakoplakia. The induction of the same process in humans by E coli endotoxin seems to be possible.
D000818:Animals; D000942:Antigens, Bacterial; D001410:Bacillus megaterium / Q000276:immunology; D002130:Calcium Phosphates; D004731:Endotoxins; D004926:Escherichia coli / Q000276:immunology; D006097:Granulation Tissue / Q000473:pathology; D002479:Inclusion Bodies / Q000648:ultrastructure; D007674:Kidney Diseases / Q000209:etiology*; D007962:Leukocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008287:Malacoplakia / Q000209:etiology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013733:Testicular Diseases / Q000209:etiology*
D000942:Antigens, Bacterial; D002130:Calcium Phosphates; D004731:Endotoxins