Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats.
Depressing functional serotonin or depleting serotonin levels in rat brains with either p-chlorophenylalanine, 5,6-dihydroxytryptamine or raphe lesions greatly enhanced hypothermia induced by chloropromazine (CPZ). Depressing the firing of raphe units or decreasing serotonin turnover in the brain with either a serotonin precursor (tryptophan) or the inhibitors of serotonin re-uptake (Lilly 1 10140 and chlorimipramine) also greatly enhanced the CPZ-induced hypothermia. The data indicate that serotonergic activity in the brain plays a role in the elaboration or modulation of CPZ hypothermia.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D002746:Chlorpromazine; D002997:Clomipramine / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology*; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D009526:Nialamide / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D014364:Tryptophan / Q000494:pharmacology
D011437:Propylamines; D005473:Fluoxetine; D012701:Serotonin; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D002997:Clomipramine; D010134:Fenclonine; D009526:Nialamide; D002746:Chlorpromazine; D015115:5,6-Dihydroxytryptamine