Cobalt induced changes in immune response and adenosine triphosphatase activities in rats.
The immuno-biochemical effects of cobaltous chloride in rats receiving iron-sufficient and deficient diets were investigated. Rats receiving 100 ppm or more cobalt showed a significant reduction in thymus and body weights along with a marked decrease in hemoglobin, hematocrit, sheep agglutinins and plaque forming cells. These effects were more pronounced in rats receiving cobalt mixed with iron-deficient diet than those fed on iron-sufficient diet. The Na+-K+ and mitochondrial (Oligomycin-sensitive) Mg2+ATPase activities in brain and liver of rats fed with iron-deficient diets were decreased significantly. However, the ATPase activities in these tissues from rats fed with cobalt mixed with iron-sufficient diets were not altered.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D005591:Chemical Fractionation; D003035:Cobalt / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D006400:Hematocrit; D006454:Hemoglobins; D006462:Hemolytic Plaque Technique; D000090463:Iron Deficiencies; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009929:Organ Size; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects
D006388:Hemagglutinins; D006454:Hemoglobins; D003035:Cobalt; D000251:Adenosine Triphosphatases