Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms.
Fifty-eight women who conceived following successful chemotherapy of gestational trophoblastic neoplasms subsequently became pregnant a total of 96 times. Seventy-eight of these 96 pregnancies or 81% terminated in live-born infants. Fifteen of the 96 or 16% ended in abortion and three or 3% terminated with stillborn infants. Among the live-born and stillborn infants there were three with congenital malformations classified as major. While this incidence of congenital malformations does not appear to be increased over that expected, the numbers are too small to perceive a two-fold increase in the expected incidence. Suggestions are made for improvements in the quality of these data.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002699:Chlorambucil / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008466:Mechlorethamine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D010921:Placenta Accreta / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D002699:Chlorambucil; D008466:Mechlorethamine; D014747:Vinblastine; D008727:Methotrexate