title: Adrenal virilism due to 21-hydroxylase deficiency in the postmenarchial female.
abstract: Five new patients with postmenarchial onset of adrenal virilism related to 21-hydroxylase deficiency are presented. Diagnostic criteria are reviewed. Four pregnancies resulting in 3 term infants occurred after instigation of therapy. Eleven patients similar in clinical presentation are reviewed for comparison. Findings of value in distinguishing these two groups of patients are discussed.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000307:Adrenal Gland Diseases / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy / Q000209:etiology / Q000652:urine; D000324:Adrenocorticotropic Hormone; D000328:Adult; D002648:Child; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D006914:Hydroxysteroids / Q000652:urine; D008572:Menarche; D008661:Metabolism, Inborn Errors / Q000150:complications*; D006899:Mixed Function Oxygenases / Q000172:deficiency*; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011279:Pregnanetriol / Q000652:urine; D013997:Time Factors; D014770:Virilism / Q000188:drug therapy / Q000209:etiology* / Q000652:urine
chemical_list: D015068:17-Ketosteroids; D006914:Hydroxysteroids; D011279:Pregnanetriol; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006899:Mixed Function Oxygenases; D011241:Prednisone