Microsomal metabolism as a determinant of aflatoxin toxicity.
The evidences to incriminate the possible role of microsomal drug metabolizing system in aflatoxin toxicity in rat have been reviewed. It is suggested that an effective drug metabolism results in decreased acute toxicity and the products of metabolism are more carcinogenic than the native toxin to the rat liver.
D000348:Aflatoxins / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D003634:DDT / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008113:Liver Neoplasms; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D000348:Aflatoxins; D003634:DDT