An uptake of fluorescein isothiocyanate labeled neocarzinostatin into the cancer and normal cells.
An uptake of fluorescein isothiocyanate labeled neocarzinostatin into normal and cancerous epithelial cells from bladder was investigated. Results showed that neocarzinostatin traversed the cell membrane into cytosol and nuclei, and it appeared to have a preferential cytotoxicity for the cancer cell.
D000903:Antibiotics, Antineoplastic / Q000031:analogs & derivatives*; D001692:Biological Transport; D004848:Epithelium / Q000378:metabolism; D005452:Fluoresceins / Q000378:metabolism; D006801:Humans; D008856:Microscopy, Fluorescence; D013861:Thiocyanates / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*; D009353:Zinostatin / Q000031:analogs & derivatives* / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D005452:Fluoresceins; D013861:Thiocyanates; D009353:Zinostatin