The role of cell receptors in tumor biology.
A general review of the role of receptors in tumor biology is presented. Nonhormonal receptors on the normal cells of the host are extremely important in the attempts to discern the origin and role of similar receptors on malignant cells. The most intriguing of these receptors is the Fc receptor which, in many respects, seems identical to the Fc receptor on B lymphocytes and macrophages. Recent data suggest chemical means of differentiating the Fc receptor of malignant cells from normal cells of the milieu. Such data are essential to resolve a controversy of the significance of the receptor and to help define the role of the receptor in the biology of tumors.
D000818:Animals; D000906:Antibodies; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D004967:Estrogens; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D007141:Immunoglobulin Fc Fragments; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology; D011956:Receptors, Cell Surface; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D004967:Estrogens; D007141:Immunoglobulin Fc Fragments; D011956:Receptors, Cell Surface