[Plasma prekallikrein activation by highly dispersed organic silica].
Human and animal blood plasm precallikrein was studied as activated by the high-dispersed preparations of silica (aerosils) which carry on their surface various chemically grafted organic radicals. It is shown that hydrophilic silica containing -COOH, -HN2, -OH groups, contrary to the hydrophobic ones, are efficient in activating human plasm precallikrein. Precallikrein activation is dependent on concentration of hydrophilic aerosil, temperature and specific surface of the activator.
D000336:Aerosols; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000502:physiology*; D010316:Particle Size; D011288:Prekallikrein / Q000502:physiology*; D012822:Silicon Dioxide / Q000494:pharmacology*; D013499:Surface Properties; D013696:Temperature
D000336:Aerosols; D012822:Silicon Dioxide; D011288:Prekallikrein; D007610:Kallikreins
Aktyvatsiia prekalikreïnu plazmy krovi vysokodyspersnymy orhanichnymy kremnezemamy