Inhibition of Newcastle disease virus-induced fever in rabbits by cycloheximide.
Pretreatment with cycloheximide prevents virus-induced fever in rabbits. Compared to the febrile control animals, CH-pretreated afebrile animals exhibit similar concentrations of endogenous pyrogen in the blood and of prostaglandins of the E-group and adenosine 3', 5'-cycle monophosphate in the cerebrospinal fluid. The fever response seems to involve one or several additional so far unknown mediators which are sensitive to cycloheximide.
D000818:Animals; D000242:Cyclic AMP / Q000134:cerebrospinal fluid; D003513:Cycloheximide / Q000627:therapeutic use*; D005334:Fever / Q000517:prevention & control*; D007275:Injections, Intravenous; D009522:Newcastle disease virus; D011458:Prostaglandins E / Q000134:cerebrospinal fluid; D011749:Pyrogens / Q000097:blood; D011817:Rabbits; D012965:Sodium Chloride / Q000627:therapeutic use
D011458:Prostaglandins E; D011749:Pyrogens; D012965:Sodium Chloride; D003513:Cycloheximide; D000242:Cyclic AMP