Congenital herpetic keratitis.
An infant, the first-born of twins, delivered by cesarean seciton without prior rupture of the membranes, was noted to have an advanced epithellal and stromal keratitis at berth. Herpes simplex, type 1, was cultured form the cornea and from skin vesicles which developed subsequently. The advanced nature of the lesion indicates that it was acquired in utero. This appears to be the first reported case of congential herpetic keratitis.
D000914:Antibodies, Viral / Q000032:analysis; D002584:Cervix Uteri / Q000382:microbiology; D002675:Child, Preschool; D003228:Conjunctiva / Q000382:microbiology; D003315:Cornea / Q000382:microbiology; D003318:Corneal Opacity / Q000151:congenital; D004200:Diseases in Twins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D007635:Keratitis, Dendritic / Q000151:congenital* / Q000235:genetics / Q000276:immunology; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D018139:Simplexvirus / Q000276:immunology / Q000302:isolation & purification
D000914:Antibodies, Viral; D007075:Immunoglobulin M