Erythrocyte adenosine kinase activity in gout.
Erythrocyte adenosine kinase (AK) (EC 2.7.1.20) and guanosine monophosphate (GMP) reductase (EC 1.6.6.8) were measured in healthy male controls and primary gout subjects. Adenosine kinase activity in 19 controls and 26 gouty subjects was 0.717 +/- 0.176 and 0.615 +/- 0.128 nmol/mg protein/h, respectively. The difference was statistically significant (p less than 0.05). GMP reductase activity in 39 controls and 46 gouty subjects was 30.90 +/- 6.28 and 33.43 +/- 7.97 mumol/mg protein/h, respectively, without statistically significant difference.
D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000201:enzymology*; D006073:Gout / Q000201:enzymology*; D006801:Humans; D008875:Middle Aged; D009247:NADH, NADPH Oxidoreductases / Q000097:blood; D009765:Obesity / Q000201:enzymology; D010770:Phosphotransferases / Q000097:blood*
D009247:NADH, NADPH Oxidoreductases; D010770:Phosphotransferases