title: Effect of cyclic nucleotides on DNA synthesis in mouse lymphoid cells.
abstract: The effect of eight cyclic purine and cyclic pyrimidine nucleotides on DNA synthesis on mouse lymphoid cells was investigated. Two out of eight compounds tested, namely 2', 3'-cyclic guanosine monophosphate (2', 3'-cGMP) as well as 3', 5'-cyclic guanosine monophosphate (3', 5'-cGMP), stimulate thymidine incorporation in all types of lymphocytes tested. The stimulatory activity of the cyclic guanosine nucleotides as well as the effects of lectins could be antagonized by 3', 5'-cyclic adenosine monophosphate (3', 5'-cAMP). 2', 3'-cGMP seems to stimulate preferentially mature T-cells while 3', 5'-cGMP preferentially acts on B-cells.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D037102:Lectins; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009712:Nucleotides, Cyclic / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial; D011685:Purine Nucleotides / Q000494:pharmacology; D011742:Pyrimidine Nucleotides / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology; D014316:Tritium
chemical_list: D037102:Lectins; D008070:Lipopolysaccharides; D009712:Nucleotides, Cyclic; D011135:Polysaccharides, Bacterial; D011685:Purine Nucleotides; D011742:Pyrimidine Nucleotides; D014316:Tritium; D004247:DNA; D000242:Cyclic AMP; D006152:Cyclic GMP; D013936:Thymidine