Effects of estrogenic compounds on triglyceride kinetics.
Paired studies of triglyceride kinetics were made in 8 women on and off postmenopausal estrogen supplementation. When estrogens were discontinued, mean very-low-density lipoprotein triglyceride (VLD-TG) and VLD-TG turnover rate fell respectively from 555 to 349 mg/100 ml, and from 30-18 mg/kg/hr (p smaller than 0.01). Maximal turnover rate (Vmax) and VLD-TG concentration at 1/2 V max (Km), were 82.4 mg/kg/hr and 704.14 mg/100 ml on estrogen and fell to 41.83 and 347.51 when estrogen was discontinued (p smaller than 0.01). Estrogen supplementation did not lengthen VLD-TG half-life or diminish the fractional turnover rate of VLD-TG. Estrogens apparently increase VLD-TG by augmenting VLD-TG production rates.
D001797:Blood Protein Electrophoresis; D002784:Cholesterol / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage*; D005260:Female; D005990:Glycerol; D006207:Half-Life; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D006867:Hydrolases / Q000097:blood; D007700:Kinetics; D008049:Lipase / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008593:Menopause; D008875:Middle Aged; D010641:Phenotype; D014280:Triglycerides / Q000097:blood*
D004966:Estrogens, Conjugated (USP); D008079:Lipoproteins, VLDL; D014280:Triglycerides; D006493:Heparin; D002784:Cholesterol; D006867:Hydrolases; D008049:Lipase; D005990:Glycerol