[Mechanism of action of T cell factors regulating antibody formation].
While the induction of antibody synthesis depends on antigen specific T cell factors, its magnitude is under control of non antigen specific T cell factors. In this respect, TRF ("T cell Replacing Factor") amplifies antibody responses while IBF ("Immunoglobulin Binding Factor") acts as a suppressor factor. Using cultures of spleen cells from nude mice, we show that both factors act sequentially, influencing the final differenciation of B cells to antibody producing cells. We have no evidence of direct interaction between TRF and IBF.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D001666:Binding Sites, Antibody; D002454:Cell Differentiation; D002455:Cell Division; D004912:Erythrocytes / Q000276:immunology; D066298:In Vitro Techniques; D007700:Kinetics; D008070:Lipopolysaccharides / Q000276:immunology; D008222:Lymphokines / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D008070:Lipopolysaccharides; D008222:Lymphokines
Approche du mécanisme d'action de facteurs de cellules T modulant la réponse anticorps.