[Effect of [ethyl p-(6-guanidinohexanoyloxy)benzoate] methanesulfonate (FOY) on kinin formation and fibrinolysis activity].
Inibitory effects of [Ethyl p-(6-guanidinohexanoyloxy)benzoate] methanesulfonate (FOY) on kinin formation (in vitro and in vivo) and the fibrinolytic activity (in vivo) were examined and compared with otherinhibitors. Inhibitory effect on kinin forming activity (in vitro) of various enzymes was measured in the guinea pig ileum. FOY and Trasylol inhibited the kinin forming activities of trypsin, pancreas kallikrein and plasma kallikrein. Soybean trypsin inhibitor inhibited kinin like substance was formed in the perfusate when the rat's paw was heated at 46 degrees C. FOY and T-asylol added to the perfusion fluid produced a potent inhibition of the formation of bradykinin-like substance. When administered i.v., FOY and Trasylol did not inhibit the formation of bradykinin-like substance. In the dog, activation of plasmin in the circulatory blood and increase of hemorrhagic tendency were caused by the i.v. administration of human serum plus streptokinase. Such responses were inhibited with a previous i.v. infusion of FOY and t-AMCHA. From the above findings, it may be concluded that FOY has inhibitory effects on kinin formation and fibrinolytic activity.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D003864:Depression, Chemical; D004285:Dogs; D005342:Fibrinolysis / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006168:Guinea Pigs; D006358:Hot Temperature; D066298:In Vitro Techniques; D007705:Kinins / Q000096:biosynthesis*; D008297:Male; D008698:Mesylates / Q000494:pharmacology; D011480:Protease Inhibitors; D051381:Rats; D013300:Streptokinase / Q000037:antagonists & inhibitors; D014361:Trypsin Inhibitors / Q000494:pharmacology
D006146:Guanidines; D007705:Kinins; D008698:Mesylates; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D007611:Aprotinin; D013300:Streptokinase