Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression.
Mice carrying the gene Mx were resistant to the lethal action of a hepatotropic line of avian influenza A virus. In resistant animals, foci of liver necrosis were self-limiting, and maximal virus titers reached were much below those in susceptible animals. Resistance could not be abrogated by immunosuppressive treatment with cyclophosphamide, methotrexate, or procarbazine, although such treatment prevented cellular infiltration at sites of virus replication and appeared to delay virus clearance. Silica and thorium dioxide, thought to inhibit macrophage function, likewise failed to abolish resistance. Regenerating liver tissue did not support more extensive virus replication than did intact adult liver.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D003520:Cyclophosphamide / Q000494:pharmacology; D006498:Hepatectomy; D007165:Immunosuppression Therapy; D008099:Liver / Q000382:microbiology* / Q000473:pathology; D008115:Liver Regeneration; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D012157:Mononuclear Phagocyte System / Q000382:microbiology; D009975:Orthomyxoviridae / Q000254:growth & development / Q000472:pathogenicity*; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000517:prevention & control*; D011344:Procarbazine / Q000494:pharmacology; D012822:Silicon Dioxide / Q000494:pharmacology; D013911:Thorium Dioxide / Q000494:pharmacology
D000956:Antigens, Viral; D011344:Procarbazine; D012822:Silicon Dioxide; D003520:Cyclophosphamide; D013911:Thorium Dioxide; D008727:Methotrexate