Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs.
The studies described were designed to examine the question of cross-reactivity between basic protein of myelin and a basic protein common to many human tumours. The lymphocytes from guinea-pigs injected with acid extracts of human cancer tissue showed significant (P less than 0-01) tranformation on exposure to basic protein of human myelin. Conversely lymphocytes from guinea-pigs injected with basic protein of human myelin showed significant (P less than 0-01) transformation on exposure to the acid extracts of human cancer tissue. Lymphocytes from control non-injected guinea-pigs did not transform on exposure to either antigen. These findings demonstrate immunological cross-reactivity in guinea-pigs between basic proteins of human myelin and of human cancer tissue using an assay system other than the macrophage electrophoretic migration hitherto used to show this effect in man.
D002759:Adenoma, Bile Duct / Q000032:analysis; D000818:Animals; D003429:Cross Reactions; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation; D008297:Male; D009186:Myelin Sheath / Q000032:analysis / Q000276:immunology*; D009363:Neoplasm Proteins / Q000276:immunology* / Q000302:isolation & purification; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000302:isolation & purification; D012004:Rectal Neoplasms / Q000032:analysis / Q000276:immunology
D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins