Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products.
Two new gamma-carboline derivatives, 3-amino-1,4-dimethyl-5H pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H pyrido[4,3-b]indole (Trp-P-2), isolated from the pyrolysis products of tryptophan, were found to be potent mutagens. When weanling rats were injected with Trp-P-1 and then given diet containing phenobarbital, they developed enzyme-altered islands in the liver. Since these islands are considered to be formed by immediate progeny of "initiated cells" and cell precursors in hepatocarcinogenesis, Trp-P-1 may well be carcinogenic in rat liver.
D000251:Adenosine Triphosphatases / Q000235:genetics; D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D006358:Hot Temperature; D007211:Indoles / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D009153:Mutagens; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats
D002243:Carbolines; D007211:Indoles; D009153:Mutagens; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; D000251:Adenosine Triphosphatases; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole