Inhibition by somatostatin of ACTH secretion in Nelson's syndrome.
Somatostatin (GHIF), when administered as a 1-hr infusion (500 mug/hr) to 5 patients with Nelson's Syndrome;resulted in a sustained, progressive fall in plasma ACTH in each patient to 40% to 71% of basal values with a return toward initail levels after cessation of the infusion.  The meanreduction in plasma ADTH was 48% (p less than 0.005).  These finding suggest that GHIF receptors not fuctional or present in normal pituitary tissue are present in ACTH-producing pituitary tumors.
D000236:Adenoma / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D013004:Somatostatin / Q000008:administration & dosage; D013577:Syndrome; D013997:Time Factors
D013004:Somatostatin; D000324:Adrenocorticotropic Hormone