title: [Lyell' syndrome: a review with special regard to the form caused by drugs (author's transl)].
abstract: The clinical evolution of Lyell' syndrome (LS), its complications, the histological findings, the nosological position and the differentiation from erythema exsudativum multiforme are dealt with. There are at least two etiological forms of LS: the LS caused by staphylococci, and the LS caused by drugs. The former mainly occurs in children, and is caused by staphylococci of the phagous group II, while the latter is mainly caused by sulfonamides, pyrazolones, penicillines, barbiturates and salicylates. The causative responsibility of a certain drug can be proved by three criteria: 1. Relapse of LS after exposure to the same drug. 2. Allergy to the drug taken before the onset of LS. 3. Positive allergy tests. The hypothesis concerning the pathogenesis of LS caused by drugs, the differential diagnosis and therapeutical guidelines are dealt with.
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001996:Bronchopneumonia / Q000209:etiology; D002493:Central Nervous System Diseases / Q000209:etiology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003231:Conjunctivitis / Q000209:etiology; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000150:complications*; D004892:Erythema Multiforme / Q000175:diagnosis; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012867:Skin / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D014777:Virus Diseases / Q000150:complications
vernacular_title: Das Lyell-Syndrom: Eine Ubersicht unter besonderer Berücksichtigung der Medikamenten-bedingten Form.