title: Studies on the relationship between concanavalin A and SV40-transformed human fibroblasts.
abstract: The extent of binding of 125I-Con A to the surface of SV40-transformed human fibroblasts and the degree of agglutination of the cells by the native lectin have been measured. In addition, trypsinized and succinylated Con A have been used to study the effects of the lectin upon certain cell growth parameters. Trypsinized Con A was found to alter the growth rate, the saturation density and the contact inhibition of the transformed cells, an effect not neutralized by alph-methyl-D-mannoside.
mesh_terms: D000371:Agglutination; D001665:Binding Sites; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003208:Concanavalin A / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D008362:Mannosides / Q000494:pharmacology; D013539:Simian virus 40
chemical_list: D008362:Mannosides; D003208:Concanavalin A