Release of xenotropic type C RNA virus in response to lipopolysaccharide: acitivity of lipid-A portion upon B lymphocytes.
The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type-C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid-A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cell plays an important role in the regulation of endogenous virus release.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000032:analysis / Q000494:pharmacology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012190:Retroviridae / Q000032:analysis / Q000502:physiology*; D012475:Salmonella; D012706:Serratia marcescens; D013601:T-Lymphocytes / Q000276:immunology
D037102:Lectins; D008055:Lipids; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D011947:Receptors, Antigen, B-Cell; D003208:Concanavalin A