[Measurement of global diffusion capacity for CO, membrane diffusion capacity for CO and capillary blood volume in patients with bronchial emphysema after fominoben HCl. Short- and long-time trials (author's transl)].
The effect of 3'-chloro-2'-(N-methyl-N-[(morpholino-carbonyl)methyl]-aminomethyl)-benzanilide hydrochloride (fominoben HCl, P-B 89 Cl, Noleptan) on the global and membrane diffusion capacities and on the capillary blood volume in patients with emphysematous bronchitis is described. All 3 parameters, independent of the severity of the emphysema and the resulting respiratory insufficiency, are increased. It can thus be concluded that fominoben by improving the ventilation-perfusion ratio leads to an enlargement of the active diffusion surface (capillary surface), from which the increase in the global diffusion capacity results. The site of action of fominoben for its positive effect on respiration is thus established as being in the alveoli.
D000328:Adult; D001810:Blood Volume; D002196:Capillaries / Q000503:physiopathology; D002248:Carbon Monoxide; D002462:Cell Membrane / Q000378:metabolism; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004058:Diffusion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D011656:Pulmonary Emphysema / Q000188:drug therapy* / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000188:drug therapy; D013997:Time Factors
D009025:Morpholines; D002248:Carbon Monoxide
Messung der globalen Diffusionskapazität für CO, der Membrandiffusionskapazität für CO und des Kapillarblutvolumens bei Patienten mit Emphysem-Bronchitis nach Fominoben-HCl. Akut- und Langzeitversuch.