Relationship between bone uptake of 99mTc-pyrophosphate and hydroxyproline in blood and urine.
In a group of hospital patients with various diseases, the urinary hydroxyproline-to-creatinine ratio showed a significant correlation (r = 0.63; p less than 0.001) with the 5-hr bone-to-soft-tissue ratio for 99mTc-pyrophosphate uptake. In patients on chronic hemodialysis, a similar correlation was found between the 5-hr bone-to-soft-tissue ratio and hydroxyproline levels in plasma and serum. The findings suggest that 99mTc-pyrophosphate binding by bone is related to collagen metabolism.
D000368:Aged; D001847:Bone Diseases / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D001842:Bone and Bones / Q000378:metabolism; D011756:Diphosphates / Q000378:metabolism; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006961:Hyperparathyroidism / Q000097:blood / Q000378:metabolism / Q000652:urine; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000378:metabolism / Q000652:urine; D011877:Radionuclide Imaging; D006435:Renal Dialysis; D013667:Technetium
D011756:Diphosphates; D013667:Technetium; D006909:Hydroxyproline