title: Ultrastructural observations on axonal swelling in the human gracile nucleus.
abstract: The morphology of the spheroids in human gracile nuclei was studied by light and electron microscopy. Various spheroids encountered in the present study could be classified into three types based on the internal structure: The first one was chiefly composed of many irregular homogeneous dense bodies, multivesicular bodies seemed to deposit multicentrically in an axon in the early stage of "ballon" formation and coalesce to form larger ones. The second was characterized by a marked accumulated of closely approximated mitochondria and dense concentric bodies. In the third the most characteristic findings were neurofibrillary accumulation and aggregations of dense bodies. These findings showed some divergence from those of dystrophic axons and the last two mimic those of degenerative or regenerative axons, which suggested that axonal swelling (including dystrophic axon) is not characteristic reaction of specific disease but rather nonspecific one to a variety of noxious stimuli. With light microscope, it was difficult to distinguish balloons with different structures since they were quite diverse and manifold in their shape, size, appearance and stainability. Intra-axonal corpora amylacea were seen in most cases and their incidence appeared to be nonspecific for any diseases.
mesh_terms: D000328:Adult; D000368:Aged; D001369:Axons / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008297:Male; D008526:Medulla Oblongata / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D009454:Neurofibrils / Q000648:ultrastructure