Inhibition of Herpesvirus hominis replication by human interferon.
The effect of human interferon on single-cycle replication of Herpesvirus hominis type 1 (HV-1) and vesicular stomatitis virus (VSV) in human foreskin fibroblast cultures (HFF) was studied. After treatment of HFF cultures with low concentrations (58 U) of human interferon, a variable but statistically significant inhibition of HV-1 was observed. At higher concentrations (greater than 95 U) yield reduction of HV in interferon-treated cultures approached that of VSV. Preliminary data indicate that antiviral activity decays more rapidly for HV-1 than for VSV after removal of interferon from cultures.
D000818:Animals; D046508:Culture Techniques; D004531:Eggs; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007668:Kidney; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology* / Q000472:pathogenicity; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D014762:Viral Interference; D014776:Virus Cultivation; D014779:Virus Replication
D007372:Interferons