Infection of capuchin monkeys (Cebus albifrons) with Herpesvirus saimiri.
Herpesvirus saimiri (HVS) induced persistent, clinically inapparent infections of long-term duration in capuchin monkeys (Cebus albifrons). The infections were characterized by development of antibody to HVS-associated antigens and recovery of low levels of virus-genome-carrying lymphocytes in the peripheral blood. Peripheral lymphocyte counts remained in low-normal to normal ranges and no physical signs of lymphoma were evident. Prednisolone treatment caused immunosuppression in one monkey; this was accompanied by a progressive loss of humoral antibody to HVS-associated antigens, but neoplastic disease did not develop.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000882:Haplorhini; D006564:Herpesviridae / Q000472:pathogenicity*; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000276:immunology; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000382:microbiology; D008934:Mitogens / Q000276:immunology; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D010948:Viral Plaque Assay
D000914:Antibodies, Viral; D008934:Mitogens; D011239:Prednisolone