Effect of neocarzinostatin on microtubules.
Effect of Neocarzinostatin (NCS) on microtubules was examined both in vitro and in vivo. Although NCS had no effect on microtubule assembly in vitro nor dissociated cytoplasmic microtubular network in vivo, microtubular network appeared to be changed to coarse form in NCS-treated 3T3 and HeLa cells. Effect of NCS on microtubules was discussed in comparison with colchicine.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells / Q000166:cytology; D006801:Humans; D008870:Microtubules / Q000032:analysis / Q000187:drug effects*; D011506:Proteins / Q000032:analysis; D013552:Swine; D009353:Zinostatin / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D011506:Proteins; D009353:Zinostatin; D003078:Colchicine