Regulation of aspartokinase and homoserine dehydrogenase in acetic acid bacteria.
The regulation of aspartokinase and homoserine dehydrogenase has been studied in three Acetobacter and two Gluconobacter species. Both enzymes were regulated by feedback inhibition. Aspartokinase was inhibited by L-threonine and concertedly inhibited by L-threonine plus L-lysine. The homoserine dehydrogenase was NADP-specific and was inhibited by L-threonine. Separation of the two enzymes by ammonium sulphate fractionation was possible in Acetobacter peroxydans, A. rancens and Gluconobacter melanogenus but not in A. liquefaciens or G. oxydans.
D000091:Acetobacter / Q000201:enzymology*; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D001222:Aspartate Kinase / Q000378:metabolism*; D001224:Aspartic Acid / Q000096:biosynthesis; D003960:Diaminopimelic Acid / Q000494:pharmacology; D005246:Feedback; D006714:Homoserine / Q000494:pharmacology; D006715:Homoserine Dehydrogenase / Q000378:metabolism*; D007532:Isoleucine / Q000494:pharmacology; D008239:Lysine / Q000494:pharmacology; D008715:Methionine / Q000494:pharmacology; D010770:Phosphotransferases / Q000378:metabolism*; D011548:Pseudomonadaceae / Q000201:enzymology*; D013912:Threonine / Q000494:pharmacology
D007532:Isoleucine; D013912:Threonine; D001224:Aspartic Acid; D003960:Diaminopimelic Acid; D006714:Homoserine; D008715:Methionine; D000429:Alcohol Oxidoreductases; D006715:Homoserine Dehydrogenase; D010770:Phosphotransferases; D001222:Aspartate Kinase; D008239:Lysine