title: [Induction of experimental diabetes in frog (author's transl)].
abstract: The effect of diabetogenic agents, alloxan and streptozotocin, in frogs has been studied. These drugs were administered to the animals by injection into the dorsal lymph sac. Alloxan did not exert any effect at non-lethal doses. At 300 mg/kg alloxan caused death of most of the animals in an hyperglycemic state in less than 72 hours. Streptozotocin at doses lower than 1 g/kg was ineffective. At 1.5 g/kg, a non-lethal dose, about half of the animals became diabetic.
mesh_terms: D000496:Alloxan / Q000008:administration & dosage; D000818:Animals; D001001:Anura; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental; D005260:Female; D007267:Injections; D007928:Lethal Dose 50; D013311:Streptozocin / Q000008:administration & dosage
chemical_list: D013311:Streptozocin; D000496:Alloxan
vernacular_title: Inducción de diabetes experimental en la rana.