Comparison of monomer, dimer and non-ionized medium at urography with simulated compression; an experimental study in the rabbit [author's transl].
Density, estimated through renal pelvic volume as calculated according to previous experiments (Owman 1978) and urinary iodine concentration, is suggested to be more accurate than, and complementary to, mere determination of urine iodine concentration and diuresis when evaluating and comparing urographic contrast media experimentally. More reliable dose optima are probably found when calculating density rather than determining urine concentrations. Of the examined media in this investigation, metrizamide and P 268 are by far superior, giving higher density, higher urinary concentrations, and metrizamide also less diuresis.
D000818:Animals; D003250:Constriction; D003287:Contrast Media / Q000008:administration & dosage*; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007455:Iodine / Q000097:blood / Q000652:urine; D007457:Iodine Radioisotopes; D011817:Rabbits; D013997:Time Factors; D014563:Urodynamics / Q000187:drug effects; D014567:Urography / Q000379:methods*
D003287:Contrast Media; D007457:Iodine Radioisotopes; D007455:Iodine