title: Release of cyclic AMP from macrophages by stimulation with prostaglandins.
abstract: The effect of various prostaglandins (PG)on the generation of cyclic AMP in rat peritoneal macrophages has been studied in vitro. PGE1 produced a rapid intracellular accumulation of cyclic AMP which was followed by its release into the extracellular space. More cyclic AMP was released with prostaglandins of the E-type than with A- and F-types. It is suggested that release of cyclic AMP from macrophages may participate in the modulation of leukocyte function.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D000242:Cyclic AMP / Q000096:biosynthesis*; D000431:Ethanol; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats
chemical_list: D011453:Prostaglandins; D000431:Ethanol; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases