title: Induction of antiviral activity in vivo and in vitro by human placenta ribonucleic acid treated with nitrous acid.
abstract: Induction of antiviral activity and interferon by human placenta ribonucleic acid deaminated with sodium nitrite (NO2-RNA) was studied in vitro and in vitro. (1) Viral multiplication in diploid cells from human kidney (HK cells) was depressed by pretreatment with NO2-RNA, but not by pre-treatment with the original placenta RNA. (2) NO2-RNA showed an interferon-inducing activity in rabbits and mice. (3) NO2-RNA sedimenting in 18 S and 28 S regions showed a higher antiviral activity than that sedimenting in 4 S region.
mesh_terms: D000225:Adenine / Q000032:analysis; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003596:Cytosine / Q000032:analysis; D005260:Female; D006147:Guanine / Q000032:analysis; D006801:Humans; D007042:Hypoxanthines / Q000032:analysis; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D051379:Mice; D009573:Nitrites / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology*; D010920:Placenta; D011247:Pregnancy; D012313:RNA / Q000032:analysis / Q000494:pharmacology*; D011817:Rabbits; D014498:Uracil / Q000032:analysis; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development; D014970:Xanthines / Q000032:analysis
chemical_list: D007042:Hypoxanthines; D009573:Nitrites; D014970:Xanthines; D014498:Uracil; D006147:Guanine; D012313:RNA; D003596:Cytosine; D007372:Interferons; D000225:Adenine; D009608:Nitrous Acid