Immunoglobulin deposits in skin in systemic lupus erythematosus.
Immunoglobulin deposits in the dermal-epidermal junction of clinically normal skin from patients with SLE were eluted by acid buffer. The eluates contained antinuclear and antibasement membrane antibody activities. The anti-BM antibody reacted with skin and esophageal but not glomerular basement membrane. Enzymatic studies indicated that the antibody reacted with carbohydrate moeities in the basement membrane. The anti-BM antibody was not present in corresponding sera of SLE patients.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; D000918:Antibody Specificity; D001485:Basement Membrane / Q000276:immunology; D003851:Deoxyribonucleases / Q000494:pharmacology; D004947:Esophagus / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006041:Goats / Q000276:immunology; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D007136:Immunoglobulins / Q000032:analysis*; D007158:Immunologic Techniques; D007668:Kidney / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D003012:Microbial Collagenase / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D009439:Neuraminidase / Q000494:pharmacology; D010504:Periodic Acid / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D012965:Sodium Chloride / Q000494:pharmacology
D000085:Acetates; D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; D007136:Immunoglobulins; D010504:Periodic Acid; D012965:Sodium Chloride; D003851:Deoxyribonucleases; D009439:Neuraminidase; D003012:Microbial Collagenase; D006851:Hydrochloric Acid