[Effect of polyvinylpyridine N-oxide on lipid metabolism indices in healthy and silicotic rats].
In the early period of investigations (in 1 month) polyvinylpyridine-N-oxide (PNO) causes a fall in the content of lipid compounds (total lipids, phospholipids, choesterol) in the liver and an inhibition of the lipolytic activity in the tissue of intratracheally quartzdust laden rats. Introduction of PNO into the lungs of dust-laden rats over a period of 4 months produces an appreciable diminution in the quantity of all the lipid components against the background of an increased lipolytic activity, recuced under the effect of quartz dust. In healthy rats PNO depresses the lipolytic activity of the pulmonary tissue and intermittently brings down the lipid compounds therein and in the spleen. In the blood of healthy and silicotic rats receiging PNO the level of the total and free cholesterol goes up. Early after administration of PNO the content of total lipids and beta-lipoproteids in the blood serum of dust-laden rats augments, while later on the concentration of total lipids goes down, while the level of summary ketone bodies rises.
D000818:Animals; D001769:Blood / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005609:Free Radicals; D006321:Heart / Q000187:drug effects; D007657:Ketone Bodies / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D011144:Polyvinylpyridine N-Oxide / Q000494:pharmacology*; D011145:Polyvinyls / Q000494:pharmacology*; D051381:Rats; D012829:Silicosis / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D005609:Free Radicals; D007657:Ketone Bodies; D008077:Lipoproteins, LDL; D010713:Phosphatidylcholines; D011145:Polyvinyls; D011144:Polyvinylpyridine N-Oxide; D002784:Cholesterol; D008049:Lipase
Vliianie polivinilpiridin-N-oksida na pokazateli lipidnogo obmena u zdorovykh i bol'nykh silikozom krys