[Effect of psychotropic and anticonvulsant preparations on the conformational transitions in transport ATPase].
The effect of neuroleptics, antidepressants, somnifacients and antiepileptic drugs on Na+- and K+-dependent transitions in the preparation of the transport ATP-ase from renal tubules of the guinea pig were looked into by using the spinal probes procedures. Neuroleptics inhibit most strongly (by 100--67 per cent) the conformant transition in the Na+- K+-dependent ATP-ase, their action manifesting itself to a greater extent with respect to the K+-dependent conformant transitions. The influence of antidepressants is close to that of the neuroleptics, although it is noticeably less intensive (78--46 per cent). The action of hypnotics (barbituric acid derivatives) and of antiepileptic drugs of a different chemical structure closely approaches, but is different from the effect of neuroleptics and antidepressants, both as concerns its intensity and the lack of any essential differences in the action upon the Na+- and K+-dependant conformant transitions.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D002414:Cations, Monovalent; D004578:Electron Spin Resonance Spectroscopy; D004794:Enzyme Repression / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D008968:Molecular Conformation; D011188:Potassium / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D013113:Spin Labels; D014149:Tranquilizing Agents / Q000494:pharmacology
D000927:Anticonvulsants; D000928:Antidepressive Agents; D002414:Cations, Monovalent; D011619:Psychotropic Drugs; D013113:Spin Labels; D014149:Tranquilizing Agents; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium
Vliianie psikhotropnykh i protivosudorozhnykh preparatov na konformatsionnye perekhody v transportnoĭ ATF-aze