Recovery of applied human leukocyte interferon from the nasal mucosa of chimpanzees and humans.
Intranasally applied human leukocyte interferon was recovered locally in 9 of 10 chimpanzees and 3 of 3 human volunteers tested. A 5- to 50-fold reduction in interferon was observed over 60 min.
D000281:Administration, Intranasal; D000818:Animals; D000882:Haplorhini; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000378:metabolism* / Q000627:therapeutic use; D007962:Leukocytes / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism*; D002679:Pan troglodytes; D012141:Respiratory Tract Infections / Q000188:drug therapy; D012229:Rhinovirus; D014777:Virus Diseases / Q000188:drug therapy
D007372:Interferons