A rare case of megaloblastic anaemia caused by disturbances in the plasma cobalamin binding proteins in a patient with hepatocellular carcinoma.
A patient with hepatocellular carcinoma, megaloblastic anaemia and increased concentration of serum cobalamin is described. Plasma TC I was increased to 10,000 times the normal concentration, thus explaining the increased concentration of serum cobalamin and a false Schilling test. The increase in plasma TC I in concurrence with undetectable amounts of plasma TC II was a likely explanation for the anaemia. The electron microscopic picture of the hepatocellular carcinoma was in accordance with TC I being produced by the tumour cells.
D000748:Anemia, Macrocytic / Q000097:blood*; D000749:Anemia, Megaloblastic / Q000097:blood* / Q000652:urine; D001798:Blood Proteins; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000473:pathology / Q000652:urine; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology / Q000652:urine; D008875:Middle Aged; D014155:Transcobalamins / Q000032:analysis
D001798:Blood Proteins; D014155:Transcobalamins