[Increased cAMP concentration in parotid secretion in arterial hypertension: relationship to plasma-renin activity (author's transl)].
Hypertensives with normal and increased plasma-renin activity have an increased salivary excretion of cyclic adenosine monophosphate (cAMP) such as can be obtained in normal persons by stimulation of beta-adrenergic fibres. Propanolol, as a beta-receptor blocker, reduces such increased cAMP levels in hypertensives to minimal levels. The results suggest that beta-receptors are stimulated in hypertensives with normal or increased renin activity.
D000242:Cyclic AMP / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D006977:Hypertension, Renal / Q000097:blood / Q000378:metabolism; D009921:Metaproterenol / Q000494:pharmacology; D010306:Parotid Gland / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D012083:Renin / Q000097:blood*; D012463:Saliva / Q000032:analysis*
D009921:Metaproterenol; D011433:Propranolol; D000242:Cyclic AMP; D012083:Renin
Erhöhte cAMP-Konzentration im Parotisspeichel des Menschen bei arterieller Hypertonie. Beziehungen zur Plasma-Renin-Aktivität