The excretion of proinsulin and insulin in urine.
Proinsulin-like components (PLC) and insulin have been measured in 24 hr urine samples from 8 healthy subjects. The mean excretion of PLC was 45.8 ng and that of insulin 314 ng; the PLC: insulin ratio was 0.14. Urinary PLC was increased 3.5 fold in a patient with a pancreatic islet cell tumor and the PLC: insulin ratio was 0.35. The urinary PLC: insulin ratio is lower than that of serum, presumably because of the relatively lower urinary clearance of the larger molecular weight PLC.
D007516:Adenoma, Islet Cell / Q000652:urine; D000328:Adult; D002850:Chromatography, Gel; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007328:Insulin / Q000652:urine*; D008297:Male; D008970:Molecular Weight; D010190:Pancreatic Neoplasms / Q000652:urine; D011384:Proinsulin / Q000652:urine*; D011863:Radioimmunoassay; D014357:Trypsin / Q000378:metabolism
D007328:Insulin; D011384:Proinsulin; D003404:Creatinine; D014357:Trypsin