The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat.
Nerve growth factor (NGF) produces a several-fold increase in the cyclic AMP concentration in rat superior cervical ganglia in organ culture within 5 min. An increase can be seen with as little as 40 ng/ml of NGF. Oxidized NGF is without effect. The increase in the cAMP concentration produced by NGF is prevented by the addition of antiserum to NGF.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000276:immunology / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011233:Precipitin Tests; D051381:Rats
D009414:Nerve Growth Factors; D000242:Cyclic AMP