Increased intraocular pressure following topical azide or nitroprusside.
In rabbits the topical administration of sodium azide (NaNs) or sodium nitroprusside (SNP) increased intraocular pressure in a dose-response manner. These agents, which activate guanylate cyclase, elevated cyclic GMP in the aqueous humor. Systemic blood pressure and pulse were not altered. Tonographic outflow facility was unchanged, suggesting an increase in aqueous humor flow as the mechanism for the elevation of intraocular pressure. Posterior chamber aqueous humor ascorbate concentration was decreased in the eye receiving the NaN3 or SNP. Systemic pretreatment with phenoxybenzamine, an alpha-adrenergic blocking agent, prevented the elevation of intraocular pressure observed following NaN3 and SNP. Pretreatment with systemic indomethacin, propranolol, or acetazolamide or the topical application of atropine or epinephrine failed to alter the elevation of intraocular pressure by either NaN3 or SNP.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects; D001205:Ascorbic Acid / Q000032:analysis; D001386:Azides / Q000494:pharmacology*; D006152:Cyclic GMP / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005292:Ferricyanides / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D011817:Rabbits
D001386:Azides; D005292:Ferricyanides; D010643:Phenoxybenzamine; D009599:Nitroprusside; D006152:Cyclic GMP; D001205:Ascorbic Acid