The metabolism of methadone by cultured mammalian cells.
Rat hepatoma tissue culture cells and mouse leukemic cells were found to metabolize [1-3H] methadone to at least 2 unidentified radioactive compounds. These results suggest that cultured cells may be useful models for studying methadone metabolism by specific cell types.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D008113:Liver Neoplasms / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D008691:Methadone / Q000378:metabolism*; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D051381:Rats
D008691:Methadone