Atopic dermatitis, eczema herpeticum, infectious mononucleosis, and depressed cell-mediated immunity.
An immunologic investigation was undertaken in a patient with atopic dermatitis and infectious mononucleosis complicated by eczema herpeticum. Humoral immunity was normal. The cell-mediated immune (CMI) response was temporarily depressed during the acute phase of the illness as measured by in vivo skin tests, and in vitro tests using T-lymphocyte population, macrophage inhibition factor, and lymphocyte transformation. It is postulated that the depression of CMI caused by infectious mononucleosis precipitated the development of eczema herpeticum in this patient.
D000328:Adult; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology*; D004485:Eczema / Q000209:etiology / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D007244:Infectious Mononucleosis / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008297:Male; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology