[Post-radiation disorders in the cyclic AMP system of mouse spleen and thymus lymphoid cells].
Early alterations in the enzyme activities controlling cyclic adenosine-3',5'-monophosphate (cAMP) metabolism after the irradiation (800 rad) of mice were found in the lymphoid cells of the spleen and thymus. Postradiation disturbances in these activities' ration induced alterations in cAMP steady-state concentrations in the cell. It was also demonstrated that irradiation reduced lymphoid cell ability to accumulate cAMP in response to isoproterenol administration.
D000262:Adenylyl Cyclases / Q000528:radiation effects*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D008297:Male; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000528:radiation effects*; D013154:Spleen / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D013950:Thymus Gland / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D014965:X-Rays
D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases
Postradiatsionnye narusheniia v sisteme tsiklicheskogo AMP limfoidnykh kletok selezenki i timusa mysheĭ.