[Hepatic adenosine-3',5'-monophosphate metabolism in newborn rats irradiated during the period of organogenesis].
The adenylate cylcase (AC) and phosphodiesterase (PDE) activities, as well as the 3'5'-AMP (cAMP) fund were studied in the liver of newborn rats, intact, and after irradiation on the 9th day of the embryonic development. A decrease of AC and PDE activities was noted with a dose of 50 r. The stationary level of cAMP in the tissue remained unchanged. The adrenaline-stimulated AC activity only tended to decrease in case of irradiation. As suggested, during critical periods of development, in the presence of the hormone inductor in the liver of irradiated rats, conditions can be created for an increase of the cAMP pool.
D000262:Adenylyl Cyclases / Q000528:radiation effects; D000818:Animals; D000831:Animals, Newborn; D003037:Cobalt Radioisotopes; D000242:Cyclic AMP / Q000528:radiation effects*; D004789:Enzyme Activation; D005720:Gamma Rays; D008099:Liver / Q000196:embryology / Q000378:metabolism / Q000528:radiation effects*; D009638:Norepinephrine / Q000494:pharmacology; D010727:Phosphoric Diester Hydrolases / Q000528:radiation effects; D051381:Rats
D003037:Cobalt Radioisotopes; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D009638:Norepinephrine
Metabolizm adenozin-3',5'-monofosfata v pecheni novorozhdennykh krys pri obluchenii v period organogeneza.