Studies on the effects of pyrogallol and the structurally related dopa decarboxylase inhibitor RO4-4602 on acetaldehyde metabolism.
Microanalytic procedures for the determination of AcH in whole blood from EtOH-intoxicated animals given PG or related drugs should utilize a hemolysis step in 0.5 N PCA in order to inhibit PG-dependent AcH production in vitro. Thiourea may also be included as an added protective measure. RO4-4602, a clinically important drug that contains a PG ring structure, is a moderate in vitro inhibitor of AldDH activity, comparable in potency to PG, chloral hydrate, or diethyldithiocarbamate.
D000079:Acetaldehyde / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors; D000818:Animals; D001545:Benserazide / Q000494:pharmacology*; D002697:Chloral Hydrate / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D000431:Ethanol / Q000378:metabolism; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D011748:Pyrogallol / Q000494:pharmacology*; D051381:Rats
D006834:Hydrazines; D011748:Pyrogallol; D000431:Ethanol; D002697:Chloral Hydrate; D001545:Benserazide; D004050:Ditiocarb; D000445:Aldehyde Oxidoreductases; D000079:Acetaldehyde