title: [Possible non-immunologic mechanism in atopic bronchial asthma].
abstract: A constitutional factor, an imbalance of cAMP/cGMP, a disturbance of adenylcyclase and a vegetative dysregulation influence the allergic type I reaction. An unspecific hyperreactivity of the bronchial system plays an important role in the asthmatic genesis. Own experiments with acetylcholine and anticholinergic drugs are described. The deduction that the complement system participates in bronchial asthma is likely from own in vivo and in vitro  experiments.
mesh_terms: D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D003165:Complement System Proteins / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D008407:Mast Cells / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
chemical_list: D011943:Receptors, Adrenergic, beta; D003165:Complement System Proteins; D000242:Cyclic AMP; D009241:Ipratropium; D006152:Cyclic GMP
vernacular_title: Mögliche nicht-immunologische Mechamismen beim atopischen Asthma bronchiale.