title: Role of brain monoamines in the anticonvulsant effect of imipramine in albino rats.
abstract: The role of brain monoamines in the anticonvulsant effect of imipramine was investigated in albino rats, against maximal electroshock-induced seizures, by using drugs with well-defined effects on brain monoamines. The results suggest a definite role for noradrenaline in imipramine anticonvulsant action. Dopamine and 5-hydroxytryptamine do not appear to be involved in this effect of imipramine.
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D001058:Apomorphine / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D004597:Electroshock; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control*; D012701:Serotonin / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D002395:Catecholamines; D006892:Hydroxydopamines; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D012701:Serotonin; D008750:Methyldopa; D012110:Reserpine; D004050:Ditiocarb; D011433:Propranolol; D006220:Haloperidol; D001058:Apomorphine; D007099:Imipramine; D010134:Fenclonine; D004298:Dopamine; D009638:Norepinephrine; D008784:Methysergide