Gonadotrophin levels in male rats following impairment of Leydig cell function by ethylene dimethanesulphonate.
The effects of the antispermatogenic compound, ethylene dimethanesulphonate on anterior pituitary and serum FSH, LH and prolactin levels in male rats were investigated. A rapid and sustained rise in serum LH, reaching castrate levels, indictated a normal pituitary response to androgen deprivation. Whilst no change in prolactin was observed, serum FSH showed a biphasic increase which is discussed in relation to the spermatogenic process.
D000818:Animals; D000988:Antispermatogenic Agents / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D007985:Leydig Cells / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D008698:Mesylates / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D051381:Rats
D000988:Antispermatogenic Agents; D006062:Gonadotropins; D008698:Mesylates; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004121:Dimethyl Sulfoxide