Serum antibody to poliovirus in patients in a mental deficiency hospital, with particular reference to Down's syndrome.
Neutralization tests for poliovirus antibodies were carried out on 74 patients in an adult mental deficiency hospital: 37 patients with Down's syndrome and 37 non-Down's mental defectives. The distribution of antibody titres to poliovirus types 1, 2 and 3 did not differ significantly between the two groups. Most patients had antibody to at least one poliovirus type but less than a third had antibodies at a titre of 1/8 or greater to all three types. The low level of poliovirus immunity in this population may be of epidemiological importance.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D006778:Hospitals, Psychiatric; D006801:Humans; D007117:Immunization, Secondary; D008607:Intellectual Disability / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated; D014611:Vaccination
D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated