Lack of a direct effect of homocysteic acid on growth hormone and prolactin receptors.
The effects of homoystine derivatives upon GH and prolactin receptors which are reported to stimulate growth in the rat were investigated. Several concentrations of homocysteic acid, homocysteine, homocysteinethiolactone, homoystine as well as other amino-acids were used in GH and prolactin receptor assay systems to determine their growth promoting or the lactogenic activities. None of the aminoacids used displaced labelled hGH or ovine PRL. It os concluded that derivatives of homoystine stimulate growth by an indirect mechanism and exhibit a lack of a direct stimulation of GH and prolactin receptors.
D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006711:Homocystine / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*
D011956:Receptors, Cell Surface; D006710:Homocysteine; D006711:Homocystine; D011388:Prolactin; D013006:Growth Hormone