Induction of simian virus 40 (SV40) transplantation immunity in mice by SV40-transformed cells of various species.
Specific tumor rejection was obtained with the use of simian virus 40 (SV40)-transformed cells from several species including man, rat, ape, sheep, and hamster. Growth of the syngeneic sarcoma mKSA in BALB/c mice was strikingly inhibited following a single immunization with as few as 10(3) intact, viable cells. Non-SV40-transformed cells did not induce tumor rejection activity nor did SV40-transformed lines induce immunity against  the 3-methylcholanthrene-induced sarcoma Meth A, syngeneic with BALB/c mice. A close relationship existed between the tumor rejection antigen, the tumor-specific transplantation antigen (TSTA) located on the plasma membrane, and the intranuclear tumor antigen (T-ag). Both were associated with the DNA sequence of the early region of the SV40 genome, and TSTA activity was found in the nucleus. However, we did not observe a close parallelism between T-ag activity and TSTA. Neverthesless, the results strongly suggested that TSTA, like T-ag, was encoded by the virus.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D003429:Cross Reactions; D005260:Female; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000209:etiology / Q000276:immunology*; D013539:Simian virus 40 / Q000276:immunology*; D013045:Species Specificity; D014185:Transplantation, Isogeneic; D014412:Tumor Virus Infections / Q000276:immunology*
D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens