[Criteria for surgical therapy of hypothalamo-hypophyseal Cushing's syndrome].
This article tries to give criteria for the two possible modes of treatment of the pituitary-dependent Cushing's syndrome. Patients (n = 6) who show no secondary complications on Cushing's disease should undergo implantation of 90Y and/or 192Ir into the pituitary gland. After implantation, the excessive secretion of ACTH is suppressed to normal values. The symptoms of Cushing's syndrome disappear. Following the operation, certain patients must also receive hormonal replacement therapy. Fertility is not always preserved. Total adrenalectomy as the alternative procedure is performed in adults with advanced symptoms of the disease (n = 3) and in children (n = 3). Following removal of the adrenal glands, the symptoms of Cushing's syndrome disappear. The appearance of Nelson's tumor after adrenalectomy (10% in the literature) is discussed.
D000236:Adenoma / Q000209:etiology; D000315:Adrenalectomy / Q000009:adverse effects; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007495:Iridium / Q000627:therapeutic use; D008297:Male; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000209:etiology; D011868:Radioisotopes / Q000627:therapeutic use; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
D011868:Radioisotopes; D015021:Yttrium Radioisotopes; D007495:Iridium; D000324:Adrenocorticotropic Hormone
Kirterien für die chirurgische Therapie bei hypothalamo-hypophysär bedingtem Cushing-Syndrom