Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil.
Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the active component was not water soluble. Similar injections of safflower oil or isotonic saline had no effect on tumor growth rate. Analysis of the tissue phospholipid fatty acids revealed that the injected corn oil caused no change in the esterified fatty acids in this lipid fraction.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000032:analysis / Q000188:drug therapy*; D005227:Fatty Acids / Q000032:analysis; D007274:Injections, Intraperitoneal; D008113:Liver Neoplasms / Q000032:analysis / Q000188:drug therapy*; D008297:Male; D009374:Neoplasms, Experimental / Q000032:analysis / Q000188:drug therapy; D009821:Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012450:Safflower Oil / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D003313:Zea mays
D005227:Fatty Acids; D009821:Oils; D012965:Sodium Chloride; D012450:Safflower Oil