Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patient.
Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 week's antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant (p less than 0.01) decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D014149:Tranquilizing Agents; D000242:Cyclic AMP