title: Isolation of two new polymyxin group antibiotics. (Studies on antibiotics from the genus Bacillus. XX).
abstract: Two new members of polymyxin group antibiotics, polymyxins S1 and T1, were isolated from the culture broths of strains identified as Bacillus polymyxa Rs-6 and Bacillus polymyxa E-12, respectively. These antibiotics are strongly basic substances, their hydrochloric acid salts are soluble in water and methanol. They are primarily active against Gram-negative bacteria in vitro and in vivo though polymyxin T1 exhibits higher activities against Gram-positive bacteria than other polymyxin group antibiotics.
mesh_terms: D001407:Bacillus / Q000145:classification / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000187:drug effects; D011113:Polymyxins / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D011113:Polymyxins