[Inhibition of the respiratory chain by the alkaloids berberine sulfate, alpinigenine, and tetrahydropalmatine].
The three alcaloids inhibited the NADH oxidase system of electron transfer particles from beef heart up to 90--100 percent. The concentrations of half-inhibition amounted to 50 muM for berberine sulphate and tetrahydropalmatine and 0.55 mM for alpinigenine. All three compounds showed comparable inhibitions on the succinate-cytochrome c oxidoreductase system only at concentrations 20--25 times as high. The site of action may be the iron sulphur region of the complex I of the electron transfer system. The biological importance of this respiratory inhibitions should be taken into account.
D000470:Alkaloids; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology; D001599:Berberine / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000494:pharmacology*; D002417:Cattle; D003580:Cytochromes; D004305:Dose-Response Relationship, Drug; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D013384:Succinate Cytochrome c Oxidoreductase / Q000037:antagonists & inhibitors
D000470:Alkaloids; D001552:Benzazepines; D001578:Benzopyrans; D001600:Berberine Alkaloids; D003580:Cytochromes; D001599:Berberine; C006478:alpinigenine; C014215:tetrahydropalmatine; D013384:Succinate Cytochrome c Oxidoreductase; D009247:NADH, NADPH Oxidoreductases
Hemmung der Atmungskette durch die Alkaloide Berberinsulfat, Alpinigenin und Tetrahydropalmatin