title: The owl monkey (Aotus trivirgatus) as an animal model for viral diseases and oncologic studies.
abstract: The owl monkey (Aotus trivirgatus) has been shown to be an excellent model for studies of oncogenic and non-oncogenic viruses. Studies at this institution have been primarily concerned with Herpesvirus saimiri, the Epstein-Barr virus, H tamarinus, and H simplex. These studies have shown that H saimiri is oncogenic when inoculated into primates, that the malignancy induced by H saimiri can be naturally transmitted from the squirrel monkey to the owl monkey, that in vitro pathogenicity of H saimiri can be modified by passing the virus in a nonpermissive cellular host, that the owl monkey is a useful model for studying the oncogenicity of the Epstein-Barr virus, and the fatal disease induced in owl monkeys by H tamarinus and H simplex can be prevented by vaccination with nonpathogenic variants of these viruses.
mesh_terms: D000818:Animals; D001029:Aotus trivirgatus; D004195:Disease Models, Animal; D000882:Haplorhini; D006561:Herpes Simplex / Q000276:immunology; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000635:transmission; D006567:Herpesvirus 2, Saimiriine; D004854:Herpesvirus 4, Human; D007945:Leukemia, Lymphoid / Q000209:etiology; D008223:Lymphoma / Q000209:etiology; D008992:Monkey Diseases / Q000209:etiology / Q000276:immunology / Q000635:transmission; D009369:Neoplasms / Q000209:etiology*; D012453:Saimiri; D018139:Simplexvirus / Q000276:immunology; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines