Lower motor neuron disease in wild mice caused by indigenous type C virus and search for a similar etiology in human amyotrophic lateral sclerosis.
In certain genetically susceptible populations of wild mice a progressive motor neuron disease with a long latent period is caused by indigenous type C leukemia virus. Neuronal damage appears to be due primarily to a direct neurotropic effect of the virus and not to an immunogenic mechanism. The disease can be prevented by antiviral genetic means. Search for a similar virus in humans with ALS has been negative.
D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D000818:Animals; D000870:Anterior Horn Cells / Q000473:pathology; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D005796:Genes; D006801:Humans; D007165:Immunosuppression Therapy; D007181:Inclusion Bodies, Viral; D008223:Lymphoma / Q000662:veterinary; D051379:Mice; D010243:Paralysis / Q000473:pathology / Q000635:transmission / Q000662:veterinary*; D012190:Retroviridae / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification; D012376:Rodent Diseases / Q000382:microbiology*; D014617:Vacuoles / Q000648:ultrastructure; D014777:Virus Diseases / Q000150:complications
D000914:Antibodies, Viral; D000956:Antigens, Viral