Effect of drugs stimulating dopaminergic system on phosphodiesterase activity in rat striatum.
Two forms of phosphodiesterase exist in the rat striatum, one with high (PDE -- I), and one with low (PDE -- II) affinity to substrate (cyclic 3',5'-AMP). The results obtained suggest that inhibition of PDE -- I activity by apomorphine or amantadine is partially related to their stimulating effect on dopaminergic system in the striatum.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000547:Amantadine / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D000547:Amantadine; D000661:Amphetamine; D010727:Phosphoric Diester Hydrolases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D001058:Apomorphine; D004298:Dopamine