Investigations on the modification of postirradiation pancreatic lipase activity by some endo- or exogenic factors. Part I. The influence of some agonists of adrenergic system.
The role of some agonists of the adrenergic system and inhibitors of phosphodiesterase activity in the modulation of the degree of lipase release from pancreatic granular fraction (zymogen and lysosomes) of control and X-ray irradiated rats was investigated. It was shown the decrease of the release of enzymatic activity under the influence of cyclic adenosine monophosphate (cAMP) and noradrenaline (NA) in the fractions from both investigated groups. Effects were dependent on the concentration used. Isoprenaline evoked opposite changes in control and irradiated specimens. In controls it facilitated the enzyme release when applied in smaller (10(-8)M) concentration. In granules from irradiated animals the decrease of enzyme release was noted under the influence of greater concentration (10(-6)M) of the drug. The action of papaverine was nearly similar in control and irradiated groups. The drug evoked the decrease or increase of enzyme release when applied in greater (10(-6)M) or smaller (10(-8)M) concentration respectively. Lipase release was markedly enhanced in controls by theophylline (both concentrations); in specimens from irradiated pancreas, however, no significant alterations were observed.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D008049:Lipase / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D010208:Papaverine / Q000494:pharmacology*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*
D013806:Theophylline; D010208:Papaverine; D000242:Cyclic AMP; D008049:Lipase; D007545:Isoproterenol; D009638:Norepinephrine