title: EM changes and other toxic effects of firemaster BP-6 (polybrominated biphenyls) in the mouse.
abstract: Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy. EM changes noted were progressive increase in size of hepatocytes, a decrease in rough endoplasmic reticulum, a marked increase in smooth endoplasmic reticulum, mitochondrial degeneration, increased lysosomes, and a decrease in glycogen. In addition, there was increasing proliferation of microvilli in bile canaliculi with increasing feeding times. A group of mice fed 1000 ppm FireMaster BP-6 in rodent chow for 11 days had livers with a mean of 13.93% of total body weight as compared with 6.49% for the control group (P=0.02). Tissue distribution following ingestion of 100 ppm FireMaster BP-6 for 14 days was studied. Twelve weeks post-feeding, the tissue concentrations of hexabromobiphenyl in order of highest concentration to lowest were as follows: perithymic fat, perirenal fat, adrenal glands, thymus gland, liver and stomach.
mesh_terms: D000821:Animal Feed; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D001835:Body Weight; D002462:Cell Membrane / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D005411:Flame Retardants / Q000633:toxicity*; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D009929:Organ Size; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D014018:Tissue Distribution
chemical_list: D001713:Biphenyl Compounds; D005411:Flame Retardants; D011075:Polybrominated Biphenyls