title: The effect of guanidine on transmitter release in the ciliary ganglion of the chick.
abstract: 1. The effect of guanidine hydrochloride on synaptic transmission at the chick ciliary ganglion was studied. 2. In bathing solution containing low calcium concentrations, guanidine produced a dose-dependent increase in the number of quanta released by the presynaptic action potential. No post-synaptic effects were observed. 3. Intracellular presynaptic recordings and monitoring of the presynaptic action potential post-synaptically via the coupling potential showed that the action of guanidine was independent of any alterations in the presynaptic spike.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002645:Chickens; D002924:Ciliary Body / Q000294:innervation; D004305:Dose-Response Relationship, Drug; D005725:Ganglia, Autonomic / Q000187:drug effects / Q000502:physiology*; D006146:Guanidines / Q000494:pharmacology*; D066298:In Vitro Techniques; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D006146:Guanidines