[Change in the reactions of isolated vascular segments to electric stimulation under the influence of inderal].
It is shown that under the effect of inderal the relaxation of isolated vascular segments in response to electric stimulation is replaced by their contraction. In the event of initial contractile reactions these are noticeably potentiated. The conditions of the experiment do not allow the effect observed to be explained by the block of specific beta-adrenergic receptors by inderal. Taking into account the data on the effect of inderal on the intracellular biochemical processes, the authors presume that one of the intimate mechanisms of changes in the vascular effects due to inderal are alterations in the content of intracellular calcium.
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D002415:Cats; D004558:Electric Stimulation; D005263:Femoral Artery / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Izmenenie reaktsiĭ izolirovannykh sosudistykh segmentov na élektrostimuliatsiiu pod vliianiem inderala.