The effect of adrenergic agonists and cyclic AMP on the Na+/K+ ATPase activity of brown adipose tissue.
The Na+/K+ ATPase activity of membrane fractions prepared from brown adipose tissue of cold-acclimated rats could be stimulated by addition of any one of the following: norepinephrine, isoproterenol, cyclic AMP or phenylephrine. These results are consistent with the proposal that in the intact brown adipocyte, the norepinephrine-induced stimulation of the Na+/K+ membrane pump is associated with alpha- as well as beta-adrenergic pathways and is, in part, mediated via cyclic AMP.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium; D051381:Rats; D012964:Sodium; D013268:Stimulation, Chemical; D013566:Sympathomimetics / Q000494:pharmacology*
D013566:Sympathomimetics; D010656:Phenylephrine; D012964:Sodium; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D007545:Isoproterenol; D011188:Potassium; D009638:Norepinephrine