Six-NB-tropic murine leukemia viruses derived from a B-tropic virus of BALB/c have altered p30.
We have examined the electrophoretic mobility on sodium dodecyl sulfate-polyacrylamide gels of three virion proteins of B-tropic murine leukemia virus from BALB/c and six of its NB-tropic derivatives. The gp70 protein and a 13,000-molecular-weight virion protein tentatively identified as p15 of the NB-tropic viruses migrated with the corresponding B virus proteins. However, the major internal structural protein of type C virions, p30, of all the NB-tropic viruses migrated more rapidly than the p30 of their B virus progenitor. Although this change in p30 raises the possibility that p30 may be involved in determining the N-, B-, or NB-tropism of MuLV's, it is also possible that the change accompanies but does not directly determine the change in tropsim.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D009052:Leukemia Virus, Murine / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology; D014764:Viral Proteins / Q000032:analysis*
D014764:Viral Proteins