[Behavior of certain parameters of lipid and energy metabolism. 3. Relationships between cyclic 3',5'-adenosine monophosphate and acetyl coenzyme A in liver of growing rats deduced from model experiments with diets differeing in fat content].
Schemes of the lipid and the pyruvate metabolism serve to show that a great part of the enzymes which intervence in the metabolic pathways and are associated with the formation and the consumption of acetyl coenzyme A may be regulated by cyclic 3',5'-adenosine monophosphate (cAMP) in the sense of activation or inhibition. The cAMP increase in the liver, which has been demonstrated in the present study for a diet containing 25% of fat, opens the metabolic pathway to the formation of acetyl coenzyme A by means of fatty acid degradation and simultaneous inhibition of lipogenesis. The deficiency of insulin (which has been evidenced in previous paper) characterizes, together with the facts mentioned, a state like diabetes or the fasting state. Acetyl coenzyme A is mainly used for energy supply. The close negative correlation between cAMP and acetyl coenzyme A (which is shown in the present paper) permits to conclude that the extent and trend of the increase and decrease in the liver is subjected to intensive hormonal control in which cAMP in involved.
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D003065:Coenzyme A / Q000031:analogs & derivatives*; D000242:Cyclic AMP / Q000502:physiology*; D004041:Dietary Fats; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006128:Growth; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D011773:Pyruvates; D000105:Acetyl Coenzyme A; D000242:Cyclic AMP; D003065:Coenzyme A
Untersuchungen zum Verhalten einiger Kenngrössen des Lipid-und Energiestoffwechsels 3. Mitt. Beziehungen zwischen cyclischem 3', 5'-Adenosinmonophosphat und Acetyl-Coenzym A in der Leber wachsender Ratten, abgeleitet aus Modellversuchen mit Ftterung unterschiedlicher Fettdiäten