Effect of clofibrate treatment on chronic hyperlipidemia induced by an ACTH-producing tumor.
Plasma triglyceride and cholesterol levels were significantly increased in rats bearing an MtT-F4 tumor for 31-41 days. Addition of clofibrate at a dose of 30 mg kg-1 to the diet of rats bearing the tumor resulted in the complete elimination of the tumor effect on the plasma triglycerides, and to a great extent prevented the rise in the plasma cholesterol.
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000627:therapeutic use*; D013006:Growth Hormone / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009374:Neoplasms, Experimental / Q000097:blood / Q000150:complications / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D002784:Cholesterol; D002994:Clofibrate