3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats.
3-Hydroxy-3-methylglutaric acid (HMG) significantly decreased cholesterol, triglyceride and phospholipid levels in whole serum, serum beta-lipoproteins and liver of Triton-induced hyperlipidemic rats. Therapeutically 50 mg HMG/kg is equivalent to 200 mg nicotinic acid/kg in lowering all these lipid parameters. HMG may exert its hypolipidemic effect through inhibition of lipoprotein synthesis.
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D005977:Glutarates / Q000627:therapeutic use*; D006880:Hydroxy Acids / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000517:prevention & control; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000032:analysis / Q000187:drug effects; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology; D010743:Phospholipids / Q000032:analysis / Q000097:blood; D011092:Polyethylene Glycols; D000644:Quaternary Ammonium Compounds; D051381:Rats; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D000924:Anticholesteremic Agents; D005977:Glutarates; D006880:Hydroxy Acids; D008077:Lipoproteins, LDL; D009539:Nicotinic Acids; D010743:Phospholipids; D000644:Quaternary Ammonium Compounds; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol