Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis.
The penetration of oral erythromycin stearate (Abboticin), administered in a dosage of 500 mg three times a day, into the maxillary sinus mucosa and secretion was studied in 15 patients (22 sinuses) operated on for chronic maxillary sinusitis. The average concentration in serum was 2.3 microgram/ml, 1.2 microgram/ml in secretion, and 1.8 microgram/ml in  mucosa. These concentrations are highly effective against diplococci and most aerobic and anaerobic streptococci (MIC value 0.06 microgram/ml) but not against Haemophilus influenzae (MIC value for 80% of 2 microgram/ml).
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004917:Erythromycin / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008443:Maxillary Sinus / Q000378:metabolism* / Q000382:microbiology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism* / Q000382:microbiology; D018108:Respirovirus / Q000302:isolation & purification; D012852:Sinusitis / Q000378:metabolism* / Q000601:surgery
D004917:Erythromycin