title: [Cholesterol synthesis in the skin of rats with rickets].
abstract: The rachitogenic diet causes an inhibition of cholesterol synthesis in rat skin. Intensity of 2-14S-acetate incorporation into cholesterol precursors (matastenol, lathosterol, 7-dehydrocholesterol) and cholesterol drops considerably. UV-irradiation of animals suffering from rachitis intensifies cholesterol synthesis in skin. Simulteneously an increase is detected in the metabolic fund of cholesterol synthesis precursors, including 7-dehydrocholesterol, which is necessary to form antirachitic compounds in the organism.
mesh_terms: D000818:Animals; D002762:Cholecalciferol / Q000172:deficiency; D002784:Cholesterol / Q000096:biosynthesis* / Q000528:radiation effects; D004032:Diet; D051381:Rats; D012279:Rickets / Q000378:metabolism*; D012867:Skin / Q000032:analysis / Q000378:metabolism* / Q000528:radiation effects; D013261:Sterols / Q000032:analysis; D013997:Time Factors; D014466:Ultraviolet Rays; D014808:Vitamin D Deficiency / Q000378:metabolism
chemical_list: D013261:Sterols; D002762:Cholecalciferol; D002784:Cholesterol
vernacular_title: Syntez kholesterynu v shkiri shchuriv za rakhitu