[Investigation of the NAD metabolism in the spleen of patients with Hodgkin's disease (author's transl)].
A correlation between the NAD metabolism and DNA synthesis, that means cell proliferation, was observed in the course of experimental studies using mouse tissues. The present studies revealed a similar correlation also in splenic tissues of patients with Hodgkin's disease. The enzymatic activities of NAD-pyrophosphorylase and NAD-glycohydrolase were measured in detail in isolated cell nuclei. NAD-pyrophosphorylase activity was particularly increased in patients with Hodgkin's disease. A decrease of enzymatic activity was seen following radiation therapy, and especially 24 hours after local irradiation of the spleen with 200 rd(60Co). These studies are in accordance with former results obtained in mice.
D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000201:enzymology; D005260:Female; D006689:Hodgkin Disease / Q000378:metabolism* / Q000532:radiotherapy; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D008297:Male; D009243:NAD / Q000378:metabolism*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000378:metabolism; D013154:Spleen / Q000201:enzymology / Q000378:metabolism* / Q000528:radiation effects; D013997:Time Factors
D009243:NAD; D009612:Nicotinamide-Nucleotide Adenylyltransferase; D006867:Hydrolases
Untersuchungen des NAD-Stoffwechsels in der Milz von Patienten mit Morbus Hodgkin.