[Effect of combinations of apressin, obsidan, diprazin, adenosine, NAD and nicotinamide on the resistance of rats to hypoxia and on carbohydrate metabolic indices].
As evidenced from experiments on rats, a combined application of apressin with obsidan and diprazine, and also of adenozine with nicotine-amidadenine-dinucleotide (NAD), as well as of adeozine with nicotine amide potentiates the protective effect of these substances in hypobaric hypoxia, increases the resistance of the animals to cerebral ischemia, brings down the excess lactate level and raises the redoz potential of the system lactic-acid-pyruvic acid in the brain of rats exposed to the effects of rarefied atmosphere.
D000241:Adenosine / Q000494:pharmacology*; D000531:Altitude; D000818:Animals; D050260:Carbohydrate Metabolism; D002561:Cerebrovascular Disorders / Q000378:metabolism; D004338:Drug Combinations; D006830:Hydralazine / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D007113:Immunity, Innate / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D008297:Male; D009243:NAD / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D004338:Drug Combinations; D007773:Lactates; D011773:Pyruvates; D009243:NAD; D009536:Niacinamide; D006830:Hydralazine; D011433:Propranolol; D011398:Promethazine; D000241:Adenosine
Vliianie kombinatsiĭ apressina, obzidana, diprazina, adenozina, NAD i nikotinamida na ustoichivost' k gipoksii i na nekotorye pokazateli uglevodnogo obmena.