title: Experimental infection of Callithrix Jacchus marmosets with Herpesvirus ateles, Herpesvirus saimiri, and Epstein Barr virus.
abstract: We inoculated common marmosets (Callithrix Jacchus) with Herpesvirus ateles (HVA), Herpesvirus saimiri (HVS), and Epstein-Barr virus (EBV). HVA-induced tumors contained several cell types, including giant cells reminiscent of the Sternberg-Reed cells observed in human Hodgkin's disease. HVS and EBV did not induce tumors, although HVS was present in lymphocytes and elicited a strong antibody response. EBV elicited only a variable antibody response. We feel that more common marmosets should be used to determine if the pathologic and immunologic lesions caused by HVA would be a suitable animal model for Hodgkin's disease and/or other malignant lymphomas of man. Inconsistency in the induction of tumors by EBV and HVS in common marmosets suggets that this species may be a different type of model for human cancer research than the cottontop marmoset, which is the most susceptible animal host for EBV and HVS oncogenesis.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis; D002143:Callitrichinae; D004195:Disease Models, Animal; D005260:Female; D000882:Haplorhini; D006564:Herpesviridae / Q000254:growth & development*; D006567:Herpesvirus 2, Saimiriine / Q000254:growth & development* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000254:growth & development* / Q000276:immunology; D006689:Hodgkin Disease; D008297:Male; D009374:Neoplasms, Experimental / Q000382:microbiology*; D009858:Oncogenic Viruses / Q000254:growth & development* / Q000276:immunology; D014776:Virus Cultivation
chemical_list: D000956:Antigens, Viral