On the mechanism of renin release by restraint stress in rats.
Restraint causes an increase in plasma renin activity (PRA) which is not affected by pretreatment with dl-propranolo (1 mg/kg IP) or sotalol (15 mg/kg IP). These doses of beta-adrenergic blocking agents are effective in suppressing the stimulation of PRA by isoproterenol. Large doses of dl-propranolol (10 mg/kg IP) and d-propranolol (5 mg/kg IP) attenuate the restraint-induced PRA increase. Adrenal demedullectomy does not affect the PRA response to restraint. Renal denervation blunts the PRA rise due to restraint, but not to direct stimulation by the beta-adrenergic agonist, isoproterenol. It is concluded that the increase in PRA during restraint stress in rats is not solely dependent on an intact renal sympathetic innervation. A significant portion of this stress-induced PRA increase appears to involve a non-adrenergic mechanism.
D000818:Animals; D003345:Corticosterone / Q000097:blood; D006801:Humans; D007668:Kidney / Q000294:innervation; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012083:Renin / Q000097:blood*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D012083:Renin; D003345:Corticosterone