[Enzymatic lipid peroxidation and oxidative metabolism of aminazine in brain microsomal fractions].
NAD (P) H-dependent enzymic systems, both of lipid peroxidation and chlorpromazine oxidative metabolism are shown to be localized in the microsomal fractions from human and rat brain. Hydroxy-derivatives of chlorpromazine (e.g. 7-OH-chlorpromazine) formed in the course of enzymic NADPH-dependent metabolism possess antioxidant activity and inhibit lipid peroxidation in the brain microsomes. The properties of enzymic NAD (P) H-dependent oxigenase systems in the membranes of the microsomal reticulum of the liver and brain are compared.
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure*; D002746:Chlorpromazine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D009243:NAD / Q000494:pharmacology; D010088:Oxidoreductases / Q000378:metabolism; D010545:Peroxides / Q000096:biosynthesis; D051381:Rats
D010545:Peroxides; D009243:NAD; D010088:Oxidoreductases; D002746:Chlorpromazine
Fermentativnoe perekisnoe okislenie lipidov i okislitel'nyĭ metabolizm aminazina v mikrosomal'noĭ fraktsii mozga.