A histochemical demonstration of the Na+ + K+-ATPase activity in the thyroid and the effect of cyclic adenosine monophosphate (c-AMP).
With a suitable modification of the Farquhar and Palade technique the Na+ + K+-ATPase activity in guinea-pig thyroid is demonstrated. The addition of c-AMP (5 X 10(-6) M or 1.5 X 10(-5) M) to the incubation media produced an apparent intensification of the Na+ + K+ -ATPase activity in the thyroid.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013961:Thyroid Gland / Q000187:drug effects / Q000201:enzymology*
D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase