Methodological aspects on drug receptor binding analysis.
Although drug receptors occur in relatively low concentrations, they can be visualized by the use of appropriate radioindicators. In most cases the procedure is rapid and can reach a high degree of accuracy. Specificity of the interaction is studied by competition analysis. The necessity of using several radioindicators to define a receptor population is emphasized. It may be possible to define isorecptors and drugs with selectivity for one isoreceptor.
D000818:Animals; D006801:Humans; D011485:Protein Binding; D011869:Radioligand Assay / Q000379:methods*; D011955:Receptors, Drug / Q000032:analysis / Q000378:metabolism*; D011957:Receptors, Opioid / Q000032:analysis / Q000378:metabolism
D011955:Receptors, Drug; D011957:Receptors, Opioid