title: [Interfering and interferonogenic activity of attenuated and original para-influenza viral strains].
abstract: A higher interfering activity of attenuated (vaccine) strains of parainfluenza virus types 1, 2 and 3 which had undergone a long-term adaptation to cell cultures as compared to the original viruses was established. The interferon-inducing activity of vaccine parainfluenza virus types 2 and 3 was also higher than that of the original viruses. The high interfering and interferon-inducing activity of attenuated parainfluenza virus strains of type 2 and 3 correlated with reduced virulence of these variants for man. These tests may be used for the assessment of virulence of parainfluenza virus strains type 2 and 3 in the laboratory.
mesh_terms: D002478:Cells, Cultured; D007369:Interferon Inducers; D010222:Parainfluenza Virus 1, Human / Q000472:pathogenicity; D010223:Parainfluenza Virus 2, Human / Q000472:pathogenicity; D010224:Parainfluenza Virus 3, Human / Q000472:pathogenicity; D018108:Respirovirus / Q000472:pathogenicity*; D014613:Vaccines, Attenuated; D014721:Vesicular stomatitis Indiana virus / Q000502:physiology; D014762:Viral Interference; D014774:Virulence; D014776:Virus Cultivation; D014779:Virus Replication
chemical_list: D007369:Interferon Inducers; D014613:Vaccines, Attenuated
vernacular_title: Interferiruiushchaia i interferonogennaia aktivnost' attenuirovannykh i iskhodnykh shtammov virusov paragrippa.