Inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+: reversal by imidazole pyruvate.
Imidazole pyruvate was found to be a very potent natural chelating agent in reversing the inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+. This metabolite may play a physiological role in gluconeogenesis.
D000818:Animals; D002614:Chelating Agents; D006597:Fructose-Bisphosphatase / Q000037:antagonists & inhibitors*; D006639:Histidine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D011817:Rabbits; D015032:Zinc / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D002614:Chelating Agents; D007093:Imidazoles; D006639:Histidine; D006597:Fructose-Bisphosphatase; D015032:Zinc