Relationship of endogenous murine xenotropic type C virus production to spontaneous transformation of cultured cells.
Spontaneous production of endogenous xenotropic viruses by clones of New Zealand Black (NZB) embryo cells occurs at a constant level even after several cell transfers. Foci of cell alteration occur spontaneously in some of the clonal lines after 6 to 10 passages. The amount of virus generated does not correlate with spontaneous transformation.. of these NZB cells nor of cells from NIH Swiss or BALB/c mice. The data demonstrate an intracellular regulation of xenotropic virus expression which remains stable over several cell generations and differs from that controlling cell transformation
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D009052:Leukemia Virus, Murine / Q000254:growth & development* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008907:Mink; D012190:Retroviridae / Q000254:growth & development* / Q000276:immunology; D014779:Virus Replication
D000956:Antigens, Viral