title: Glycoproteins of natural origin with an affinity for hepatitis B surface antigen.
abstract: Sera from certain animal species contain a substance(s) which binds hepatitis B surface antigen. The hepatitis B binding substance found in animals is not antibody, but appears to be a glycoprotein which reacted with antigen-coated beads and produced a "false positive" test for antibody. This glycoprotein could be selectively and quantitatively removed by reaction with purified hepatitis B surface antigen and centrifugation. Pili fractions isolated from Neisseria gonorrhoeae and Escherichia coli bound to hepatitis B surface antigen and produced false positive anti-hepatitis B surface antigen reactions. Mouse anti-bovine hepatitis B binding substance and rabbit anti-E. coli pili were capable of neutralizing bovine hepatitis B binding substance.
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000302:isolation & purification*; D002417:Cattle; D004926:Escherichia coli / Q000378:metabolism; D006023:Glycoproteins / Q000302:isolation & purification*; D006514:Hepatitis B Surface Antigens; D037102:Lectins / Q000378:metabolism; D007938:Leukemia / Q000382:microbiology / Q000662:veterinary; D001909:Leukemia Virus, Bovine; D009344:Neisseria gonorrhoeae / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D006023:Glycoproteins; D006514:Hepatitis B Surface Antigens; D037102:Lectins