High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication.
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified BK virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV T-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendal virus-mediated fusion with Vero cells. A low, or lack of, oncogenic activity was displayed by BKV inoculated sc, ip, or iv.
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral; D001739:BK Virus / Q000276:immunology; D001932:Brain Neoplasms / Q000209:etiology* / Q000276:immunology; D006224:Cricetinae; D004806:Ependymoma / Q000209:etiology* / Q000276:immunology; D006822:Hybrid Cells / Q000276:immunology; D008647:Mesocricetus; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology; D012513:Sarcoma, Experimental / Q000209:etiology / Q000276:immunology; D014412:Tumor Virus Infections / Q000209:etiology*
D000956:Antigens, Viral