[Effect of thiophosphamide, its paramagnetic analogs and the iminoxyl radical on the division of tumor cells].
The authors have studied the effect of thiophosphamide its paramagentic analogs and iminoxyl radical on cell reproduction of Ehrlich ascites tumor. It was shown that the effect of paramagnetic analogs is made up of a sum of injuries produced by ethylenimine and iminoxyl portions of molecules. One of the analogs involved proves to be more active than thiophosphamide.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D003497:Cyclic N-Oxides / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000037:antagonists & inhibitors; D004353:Drug Evaluation, Preclinical; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D013852:Thiotepa / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013997:Time Factors
D003497:Cyclic N-Oxides; D004273:DNA, Neoplasm; D005609:Free Radicals; D013852:Thiotepa
Vliianie tiofosfamida, ego paramagnitnykh analogov i iminoksil'nogo radikala na delenie opukholevykh keltok.