[Effect of chronic action of cadmium sulfate on various biochemical indices of blood serum and on the histological picture of rat liver and kidneys].
Male rats weighing 180-220 g were given CdSO4, 0,4 mg/kg body weight subcutaneously once a week for 6-12 months. The animals were killed after 6, 9, 12 months and following blood serum levels were determined: total protein, albumin, globulin, GPT, GOT, Al.P. and urea. The tissue tissue samples from liver and kidneys were examined histologically (acid and alkaline phosphatase). After 9 months, the difference between values of biochemical indices in the exposed and control groups was statistically significant. It has been found that the observed biochemical indices show correlation with the extent of morphological changes in liver and kidneys. These degenerative changes became more intense in the liver than in the kidneys.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002105:Cadmium Poisoning / Q000473:pathology*; D002908:Chronic Disease; D006651:Histocytochemistry; D007668:Kidney / Q000201:enzymology / Q000473:pathology*; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D012709:Serum Albumin / Q000032:analysis; D000637:Transaminases / Q000097:blood; D014508:Urea / Q000097:blood
D001798:Blood Proteins; D012709:Serum Albumin; D014508:Urea; D000637:Transaminases; D010744:Phosphoric Monoester Hydrolases
Wpływ przewlekłego działania siarczanu kadmu na niektóre wskaźniki biochemiczne surowicy krwi oraz na obraz histologiczny watroby i nerek szczurów.