Tumour-specific antibodies reactive with cell-surface antigens in children with Wilms' tumour.
Tumour-specific antibodies directed against membrane antigens were demonstrated by immunofluorescence in three of 45 patients with Wilms' tomour. Antibody capable of collaborating with K cells to kill Wilms' tumour was present in two additional patients. No patient exhibited both membrane immunofluorescence and K-cell collaborating antibody. Of 27 patients with non-renal solid tumours and 52 age-matched controls, none possessed tumour-specific antibody.
D000293:Adolescent; D000912:Antibodies, Neoplasm / Q000032:analysis; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000032:analysis; D002462:Cell Membrane / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005347:Fibroblasts / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007668:Kidney / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology; D009396:Wilms Tumor / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm