Inhibition of actions of glucagon in adipocytes by gastric inhibitory polypeptide.
Possible interactions between gastric inhibitory polypeptide (GIP) and glucagon were investigated in rat adipocytes. GIP was nonlipolytic and inhibited lipolysis stimulated by glucagon but not that stimulated by secretin or vasoactive intestinal polypeptide (VIP). GIP competed with 125I-glucagon for binding to adipocyte receptors, and at physiologic concentrations inhibited the stimulation of AMP produced by glucagon. Thus GIP acts as an inhibitor of actions of glucagon on adipocytes and may be a physiologic modulator of effects of glucagon.
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D004822:Epididymis; D005749:Gastric Inhibitory Polypeptide / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005934:Glucagon / Q000037:antagonists & inhibitors* / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology
D005768:Gastrointestinal Hormones; D011956:Receptors, Cell Surface; D005749:Gastric Inhibitory Polypeptide; D005934:Glucagon; D013806:Theophylline; D000242:Cyclic AMP