Antitumor activity of 1,2-bis diazoacetyl ethane.
1,2-Bis diazoacetyl ethane (diazane) was selected for a detailed study as the most active compound in a large group of mono- and bi-functional diazoketones subjected to screening. In this paper data on the toxicity and cumulative and antitumor effects of diazane are reported. Diazane markedly inhibits the growth of certain experimental tumors and increases the mean survival time of animals with leukemias, even after a single injection. The drug is characterized by a high level of accumulation in the body.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents; D001391:Azo Compounds / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D003979:Diazonium Compounds; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D007958:Leukocyte Count; D008113:Liver Neoplasms; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D013154:Spleen / Q000187:drug effects; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D001391:Azo Compounds; D003979:Diazonium Compounds; D013386:Succinates; C000279:diazan