Inhibition of cortiocosteroidogenesis by delta-9-tetrahydrocannabinol.
ACTH, cholera toxin, cyclic AMP but not pregnenolone-induced steroidogenesis in Y-1 functional mouse adrenal tumor cells was significantly inhibited by delta-9-tetrahydrocannabinol, cannabidiol, and cannabinol. The inhibition of steroidogenesis could not be correlated with a general depression in cell function or viability. The data suggest that cannabinoids inhibit corticosteroidogenesis at a site between the synthesis of cAMP and of pregnenolone.
D004092:20-alpha-Dihydroprogesterone / Q000096:biosynthesis*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002772:Cholera Toxin / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D011284:Pregnenolone / Q000494:pharmacology; D011374:Progesterone / Q000031:analogs & derivatives*
D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone; D011284:Pregnenolone; D013759:Dronabinol; D000324:Adrenocorticotropic Hormone; D002772:Cholera Toxin; D003513:Cycloheximide; D000242:Cyclic AMP