title: Cholecalciferol metabolites binding in porcine parathyroid glands.
abstract: We studied the cytoplasmic and nuclear binding of 25-hydroxychole-calciferol and 1alpha,25-dihydroxycholecalciferol inside porcine parathyroid glands. Both sterols bind to cytoplasmic components, but a specific nuclear uptake was demonstrated only for 1alpha,25-dihydroxycholecalciferol. These findings support the hypothesis that mammalian parathyroid glands are a target organ for some cholecalciferol metabolites.
mesh_terms: D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000378:metabolism; D002762:Cholecalciferol / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000378:metabolism; D066298:In Vitro Techniques; D010280:Parathyroid Glands / Q000378:metabolism*; D013552:Swine
chemical_list: D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D002762:Cholecalciferol