Antibodies to bacterial and tumor-derived antigens in sera from normal guinea pigs.
Antibodies that react with radiolabeled antigens derived from guinea pig line-10 tumor cells and Mycobacterium bovis (BCG) were detected in sera from normal tumor-free strain-2 guinea pigs (NGPS). Binding by NGPS to the two antigens was inhibited by extracts of either line-10 cells or BCG. Binding by NGPS to the line-10 antigen was inhibited by a number of other bacterial extracts. NGPS was tested after absorption with a variety of cells including line-10, line-1, normal guinea pig spleen, normal adult and fetal liver cells. Results indicated that some of the antibodies in NGPS were directed to line-10-specific determinants. The specific stimulating antigen for these antibodies was not identified but because of the antigenic relationship between BCG, line-10 cells and other bacteria, antibodies to line-10-associated antigens might have been induced by exposure to environmental microorganisms.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D001886:Bordetella pertussis / Q000276:immunology; D002003:Brucella abortus / Q000276:immunology; D003429:Cross Reactions; D004781:Environmental Exposure; D004926:Escherichia coli / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology*; D011425:Propionibacterium acnes / Q000276:immunology; D011549:Pseudomonas / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology
D000907:Antibodies, Bacterial; D000912:Antibodies, Neoplasm