title: [Testing the activity of anti-foot-and-mouth disease vaccine in cattle: quantitative methods of antigenic extinction].
abstract: Two methods of evaluating the activity of the foot-and-mouth disease vaccine are compared, leading to the evaluation of the number of protective doses 50% or potency. These methods differ in sensitivity, precision and equivalence potency-percentage of protection. For the same vaccine the value of the PD50 is always larger than that of Pb. We chose the Pb method using a diluent containing no adjuvant. Standards based on the evaluation of average potency have not been taken into consideration; only those standards based on the evaluation of minimum potency ensure respect of OIE's recommendation. This recommendation: 70% minimum potency with 0.95 probability is not an easier alternative, since the average protection observed corresponds in fact to at least 90% taking into account the biological variability of bovines.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000008:administration & dosage / Q000032:analysis*; D005537:Aphthovirus / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D002418:Cattle Diseases / Q000517:prevention & control; D005536:Foot-and-Mouth Disease / Q000517:prevention & control; D008722:Methods; D014765:Viral Vaccines / Q000008:administration & dosage / Q000592:standards*
chemical_list: D000956:Antigens, Viral; D014765:Viral Vaccines
vernacular_title: Contrôle d'activité du vaccin antiaphteux sur bovins: méthodes quantitatives d'extinction antigénique.