Inhibition of evoked tongue jerks during the rat's cerebral ventricles perfusion with gamma-aminobutiric acid and beta-phenyl-gamma-aminobutiric acid.
The supraorbital branch of the trigeminal nerve of rats in chloralose anaesthesia was stimulated with electrical pulses. The stimulation of the afferent fibres of the trigeminal nerve evoked the retractive jerks of the outstretched tongue. These evoked tongue jerks (ETJ) were recorded on the tape of the line recorder through an isotonic transducer. The caniulae were inserted into the lateral cerebral ventricles by means of streotaxic apparatus and perfusion was performed with inflow of GABA or beta-phenyl-GABA-containing fluid into the right lateral ventricle and outflow through the left lateral ventricle. Perfusion with solution of 0.01 mol/l GABA reduced the amplitude of ETJ 25.9% while perfusion with hypertonic NaCl solution increased it by 19.5%, and perfusion with solution of 0.2 mol/l beta-phenyl-GABA reduced that amplitude by 39.9%.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D002552:Cerebral Ventricles; D004558:Electric Stimulation; D009475:Neurons, Afferent / Q000502:physiology*; D010477:Perfusion; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D014059:Tongue / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000613:Aminobutyrates; D012462:Saline Solution, Hypertonic; D005680:gamma-Aminobutyric Acid