title: Value of exchangeable electrolyte measurement in the treatment of myasthenia gravis.
abstract: We have investigated electrolyte exchange in myasthenia gravis before and after corticotrophin therapy, using a four-isotope dilution technique. Clinical deterioration in patients on corticotrophin is associated with a fall of more than 20% in the intracellular potassium concentration, suggesting that all myasthenics so treated should be given potassium supplementation.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D003366:Cosyntropin / Q000627:therapeutic use*; D004573:Electrolytes / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D009157:Myasthenia Gravis / Q000188:drug therapy* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism
chemical_list: D004573:Electrolytes; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D011188:Potassium