[Comparison of structural and functional organization of adrenocorticotropic hormone and wasp kinin].
A comparative study of structural and functional organization of the polypeptides -- ACTH and wasp kinin was made. The effects of fragments Lys 17, 18-ACTH11(-18)-NH2--(I) and WK4(-12)--(II), possessing "common" fragments and a cluster of basic amino-acids, on the lipolytic and steroidogenic effects of ACTH and myotropic effects of bradykinin were studied. Both fragments I and II potentiate ACTH-induced lipolysis and steroidogenesis in isolated rat fat and adrenal cells but suppress the myotropic effect of bradykinin on guinea pig ileum. The similarity of biological effects of ACTH and WK fragments support our supposition on the similarity in structurally functional organization of these peptides.
D000273:Adipose Tissue / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007705:Kinins / Q000494:pharmacology; D050356:Lipid Metabolism; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D013256:Steroids / Q000096:biosynthesis; D014863:Wasps
D000596:Amino Acids; D007705:Kinins; D010446:Peptide Fragments; D013256:Steroids; D000324:Adrenocorticotropic Hormone
Sravnenie strukturno-funktsional'noĭ organizatsii molekuly aktg i kinina iz iada osy