Antipyretic and antiviral action of vitamin A in Moloney sarcoma virus- and poxvirus-inoculated mice.
Six week-old male CBA/J mice fed a commercial powdered laboratory chow or the same chow supplemented with vitamin A palmitate (150,000 U/kg) were inoculated with either the Moloney strain of murine sarcoma virus (M-MuSV) or poxvirus. Central body temperature was measured daily. Both viruses elicited fevers, but the fevers were less pronounced and of shorter duration in the mice ingesting the vitamin A-supplemented diet. Palpable M-MuSV-induced tumors appeared later, were less frequent, grew more slowly, and were resorbed sooner in the mice fed the vitamin A supplement. Similarly, in these mice the appearance of pox lesions was delayed, their numbers reduced, and their disappearance hastened.
D000700:Analgesics; D000818:Animals; D000998:Antiviral Agents; D005334:Fever / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008979:Moloney murine leukemia virus; D011213:Poxviridae Infections / Q000150:complications / Q000188:drug therapy*; D012513:Sarcoma, Experimental / Q000150:complications / Q000188:drug therapy*; D014801:Vitamin A / Q000494:pharmacology* / Q000627:therapeutic use
D000700:Analgesics; D000998:Antiviral Agents; D014801:Vitamin A