Phosphatidylinositol-degrading enzymes in liver lysosomes.
The major pathway by which liver lysosomal enzymes degrade phosphatidylinositol is through an EDTA-insensitive formation of phosphorylinositol. This is in distinct contrast with the Ca2+-dependent production of phosphorylinositol from phosphatidylinositol, which is located in the cytosol. Lysosomal enzymes can also totally deacylate phosphatidylinositol, producing glycerophosphorylinositol.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D009708:Nucleotidases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats
D010716:Phosphatidylinositols; D007770:L-Lactate Dehydrogenase; D003576:Electron Transport Complex IV; D009708:Nucleotidases; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase