Perhexiline induces generalized lipidosis in rats.
Administration of perhexiline (Pexide) to rats causes generalized occurrence of lamellated and crystalloid cytoplasmic inclusions which resemble those described in patients with perhexiline-induced polyneuropathy. It is concluded that perhexiline being an amphiphilic cationic compound is a potent inducer of generalized lipidosis.
D000818:Animals; D002479:Inclusion Bodies / Q000187:drug effects; D008064:Lipidoses / Q000139:chemically induced*; D010480:Perhexiline / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats
D010880:Piperidines; D010480:Perhexiline