Multiple hepatic tumors and peliosis hepatis in Fanconi's anemia treated with androgens.
We report the case of a 13-year-old boy who was known to have Fanconi's anemia for five years. For treatment of this condition he was given androgens and corticosteroids. Two months before his death, severe varicella developed complicated by pneumonia, jaundice, and prolonged fever; all of which resolved during a five-week hospitalization. Three weeks later he died of Clostridium septicum sepsis caused by necrotizing enterocolitis. At autopsy he was found to have multiple hepatocellular neoplasms. A striking feature of the neoplasms was cholestasis. The liver also showed peliosis hepatis. The association of the use of certain androgenic steroids with hepatic neoplasms histologically resembling hepatocarcinomas, but characterized by lack of metastases and apparent reversibility, suggests the desirability of a new nomenclature for these hepatocellular lesions.
D000293:Adolescent; D000728:Androgens / Q000009:adverse effects / Q000627:therapeutic use*; D000741:Anemia, Aplastic / Q000150:complications*; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis; D005199:Fanconi Anemia / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis; D008113:Liver Neoplasms / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D008297:Male; D010110:Oxymetholone / Q000009:adverse effects / Q000627:therapeutic use; D011693:Purpura / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D013739:Testosterone / Q000627:therapeutic use
D000728:Androgens; D013739:Testosterone; D010110:Oxymetholone