Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D004149:Dioxoles / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000139:chemically induced*; D051379:Mice; D009153:Mutagens; D009154:Mutation / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012451:Safrole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D012513:Sarcoma, Experimental / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*; D013329:Structure-Activity Relationship
D002273:Carcinogens; D004149:Dioxoles; D009153:Mutagens; C012376:1'-hydroxysafrole; D012451:Safrole; D010634:Phenobarbital