Malignant tumors in rats fed nafenopin, a hepatic peroxisome proliferator.
Nafenopin (2-methyl-2-[P-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy] propionic acid; Su-13,437), a potent hypolipidemic hepatic peroxisome proliferator, was fed to male F344 rats at a dietary concentration of o.1% until the end of the experiment at 25 months. Between 18 and 25 months, 12 of 15 rats (80%) developed tumors. Approximately 73% (11/15) developed hepatocellular carcinomas, and 10% (3/15) developed pancreatic acinar cell tumors, including 1 metastasizing carcinoma. The hepatocellular carcinomas as well as the acinar cell carcinoma of the pancreas were transplantable successfully through 6 generations.
D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008830:Microbodies / Q000187:drug effects; D009255:Nafenopin / Q000009:adverse effects*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D011422:Propionates / Q000009:adverse effects*; D051381:Rats; D011916:Rats, Inbred F344; D013736:Testicular Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D011422:Propionates; D009255:Nafenopin