Phosphoprotein phosphatase-catalyzed dephosphorylation of the 22,000-dalton phosphoprotein of cardiac sarcoplasmic reticulum.
Similar time courses were obtained for decreases in the rate of calcium transport by cardiac sarcoplasmic reticulum vesicles previously phosphorylated by cAMP-dependent protein kinase and dephosphorylation of the 22,000-dalton phosphoprotein in these membranes. Dephosphorylation of the 22,000-dalton phosphoprotein can be attributed to a phosphoprotein phosphatase in the sarcoplasmic reticular membranes. This membrane-bound phosphoprotein phosphatase may play a role in the reversal of the relaxation-promoting effect of catecholamines on the heart.
D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D007700:Kinetics; D008565:Membrane Proteins; D008566:Membranes / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D008970:Molecular Weight; D009206:Myocardium / Q000378:metabolism*; D009994:Osmolar Concentration; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010750:Phosphoproteins; D011494:Protein Kinases / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D008565:Membrane Proteins; D010750:Phosphoproteins; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D002118:Calcium