[Oedematous optic neuropathy from Perhexilline maleate associated with peripheral polyneuropathy (author's transl)].
The authors report on a polyradiculoneuropathy related to long-term treatment with Perhexiline maleate (a drug used in France since 1973 for coronary insufficiency) whose presenting sign is a bilateral aedematous optic neuropathy. The mechanism of this effect on the optic nerves and on papilloedema is discussed; it seems not to be caused by a direct toxic action on the optic fibres but by the existence of chronic intracranial hypertension.
D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000150:complications; D010211:Papilledema / Q000139:chemically induced; D010480:Perhexiline / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000150:complications*; D010880:Piperidines / Q000009:adverse effects*
D010880:Piperidines; D010480:Perhexiline
Neuropathie optique oedémateuse au maléate de Perhexiline associée à une polyneuropathie périphérique.