Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined antigens II. Induction of ADCC by FC-FC receptor bridging.
Four different methods to test antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus (EBV) determined antigens were analysed. It was found that optimal ADCC was obtained if viral antigens were present during the cytotoxicity reaction and that killing probably was mediated by EBV-related immune-complexes forming Fc-Fc receptor bridges between Fc receptor-bearing effector cells and Fc receptor-bearing target cells. Only lymphoid target cells with a high expression of Fc receptors were found to be susceptible in this particular system.
D000818:Animals; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D003176:Complement C3; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D008214:Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G