Drinking in water deprived rats after combined central angiotensin receptor and converting enzyme blockade.
Saralasin, an angiotensin II receptor antagonist, is ineffective in reducing drinking after water-deprivation (WD). Angiotensin III has considerable dipsogenic potency. It may be formed without angiotensin II as an intermediate. To clarify whether angiotensin III formation masks a role for angiotensin in WD, 48 hr WD rats were infused via a lateral cerebroventricle with a) CSF, b) Saralasin, c) SQ 20,881, a converting enzyme inhibitor, or d) Saralasin + SQ. No drug effect on drinking was observed. The results demonstrate that angiotensin III is not required for WD drinking.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D012504:Saralasin / Q000494:pharmacology; D012964:Sodium / Q000652:urine; D013722:Teprotide / Q000494:pharmacology; D013997:Time Factors; D014868:Water Deprivation
D000806:Angiotensin-Converting Enzyme Inhibitors; D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D012964:Sodium; D013722:Teprotide; D012504:Saralasin; D011188:Potassium