EBNA antibodies are more useful than complement fixing antibodies in monitoring infectious mononucleosis patients.
Thirty-six patients with infectious mononucleosis (IM) were followed prospectively for both anti-Epstein-Barr virus nuclear antigen (EBNA) and complement-fixing antibodies using the soluble EBV antigen (CF/S). Discrepancies in time between the two reactivities were found, due to the differences in sensitivity of the tests. It is suggested that, in clinical virology laboratories, EBNA and not CF/S tests be used.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D007244:Infectious Mononucleosis / Q000175:diagnosis*; D012698:Serologic Tests / Q000379:methods; D013997:Time Factors
D000914:Antibodies, Viral