The characteristics of human plasma lipoprotein metabolism: influence of low caloric diet on hyperlipidemia.
We have classified hyperlipidemia into three groups according to different levels of VLDL-TG, and postulated the effect of low calorie-diets on plasma TCh are as follows: 1) Low calorie-diets are effective on VLDL-TG in every type of hyperlipidemia, except hyperlipidemia with VLDL-TG under 180 mg/100ml; 2) There was a reciprocal relation between the decreased amount of plasma TCh and the change VLDL-TG induced by the diet; 3) Catabolism of VLDL was accelerated by an increased esterification of VLDL-FC; 4) In the the group with VLDL-TG less than or equal to 180 mg/100ml, the LDC showed a high level of TCh: protein ration, and in the group with VLDL-TG greater than or equal to 260 mg/100ml, there was to be low level of TG: protein ratio in VLDL: 5) In hyperlipidemia with plasma TCh unchanged by the diet LDL-TCh increased significantly without any increase in LDL protein and LDL-TG.
D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D007037:Hypothyroidism / Q000150:complications; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D001053:Apolipoproteins; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol