Canine Zollinger-Ellison syndrome.
The unusual finding of peptic esophagitis and duodenal ulceration in a dog was associated with a malignant pancreatic islet cell tumor producing gastrin and ACTH. The finding of a gastrinoma in a non-human species introduces the potential for developing an animal model for the study of the protean genetic biochemical, physiologic and metabolic aspects of the Zollinger-Ellison syndrome.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D005755:Gastrins / Q000097:blood / Q000276:immunology; D011863:Radioimmunoassay; D015043:Zollinger-Ellison Syndrome / Q000601:surgery / Q000662:veterinary*
D005755:Gastrins; D000324:Adrenocorticotropic Hormone