Viral growth in splenic megakaryocytes of mice experimentally infected with mouse hepatitis virus, MHV-2.
Electron microscopic and immunofluorescence studies were made on the spleen of mice infected intraperitoneally with mouse hepatitis virus, MHV-2. Virions and their budding process were demonstrable in reticulum cells as well as megakaryocytes at early stage of infection with a marked decrease in number of peripheral platelets, while histiocytes and macrophages were also found to have a large number of virions at later stage.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D006524:Hepatitis, Viral, Animal / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D006517:Murine hepatitis virus; D013154:Spleen / Q000382:microbiology* / Q000473:pathology