The effects of various protein synthesis inhibitors on the sleep-wake cycle of rats.
The present investigation sought to determine the effects of Anisomycin (A), Chloramphenicol (ChA), Vincristine (V), and Penicilline G on the sleep-wake cycle of rats. It was found that both high and low doses of anisomycin decreased rapid eye movement (REM) sleep, while only high doses of ChA and V produced such a decrease. Slow wave sleep (SWS) was unaffected by these drugs. Penicilline G, on the other hand, had no effect on the sleep-wake cycle. It was further shown that the reduction of REM sleep was the result of a decrease in the number of REM periods rather than in the duration of each individual period. These results suggest that protein synthesis may participate in the mechanisms that trigger REM sleep.
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D003864:Depression, Chemical; D004569:Electroencephalography; D008297:Male; D010400:Penicillin G / Q000494:pharmacology; D014176:Protein Biosynthesis; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects*
D011759:Pyrrolidines; D014750:Vincristine; D002701:Chloramphenicol; D000841:Anisomycin; D010400:Penicillin G