title: The isolation of defective variants of simian virus 40 whose genomes contain sequences derived from adenovirus 2 DNA.
abstract: A new set of hybrid viruses has been isolated whose closed circular genomes 5 to 6 kB in size, contain DNA sequences derived in part from adenoviruses 2 and in part from SV40. The structure of these genomes is complex, but in the simplest case, analyses by restriction endonuclease digestion and hybridization indicate that the adenovirus 2 DNA is present as a continuous block, of maximum size 2.8 kB. Different hybrids contain sequences derived from different segments of the adenovirus 2 genome.
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000261:Adenoviruses, Simian / Q000235:genetics*; D001483:Base Sequence; D004279:DNA, Viral; D003673:Defective Viruses / Q000302:isolation & purification*; D005816:Genetic Complementation Test; D014644:Genetic Variation; D009693:Nucleic Acid Hybridization; D013539:Simian virus 40 / Q000235:genetics*
chemical_list: D004279:DNA, Viral