[1 alpha-hydroxyvitamin D3: chemical synthesis and biological effect].
A method for the synthesis of an analog of vitamin D3--1alpha-hydroxy vitamin D3 (1alpha-OH D3) from cholesta-4,6-dien-3beta-ol was developed. Biological activity of this compound in the chick organism was measured. The growth stimulating effect of 1alpha-OH D3 and its effect on bone tissue mineralization and serum biochemical parameters (content of calcium, inorganic phosphorus and activity of alkaline phosphatase) were 4--5 times higher than those of vitamin D3 in low doses (19.5--39 pmole/day). In chicks given 1alpha-OH D3 at doses of 39--195 pmole/day most biochemical parameters reached plateau typical of chicks adequately provided with vitamin D. A peculiar feature of 1alpha-OH D3 was a rapid response of the chick organism to/low doses.  As early as one hour after intramuscular injection of 650 pmole of 1alpha-OH D3 to D-avitaminotic chicks, the content of calcium-bound protein in the intestinal mucosa and active transport of calcium ions in the inverted intestinal sac increased drastically. It was demonstrated that 1alpha-OH D3 showed antirachitic action, when the physiological reaction to vitamin D3 was inhibited by dietary strontium.
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D002762:Cholecalciferol / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000378:metabolism; D013268:Stimulation, Chemical; D014808:Vitamin D Deficiency / Q000188:drug therapy
D002352:Carrier Proteins; D002762:Cholecalciferol; D002118:Calcium
1 alpha-oksivitamin D3: khimicheskiĭ sintez i biologicheskoe deĭstvie.