Murine leukemia induced by viral ultrafiltrates negative for XC plaque activity.
Leukemogenic activity has been encountered in 100 nm filtrates of a murine leukemia virus, PLLV-T2, associated with smaller than conventional C type particles. XC plaque assay of these filtrates gave negative results, revealing a lack of correlation between in vivo and in vitro activity. It is postulated that these filtrates contain viral subunits deficient for replication in BALB fibroblasts in vitro but able to transform lymphoid cells in vivo.
D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D005374:Filtration; D009052:Leukemia Virus, Murine / Q000472:pathogenicity; D007942:Leukemia, Experimental / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012190:Retroviridae; D010948:Viral Plaque Assay