[Tumor hyperacidulation through glucose infusion enhanced by nicotinamide adenine dinucleotide (author's transl)].
Tumor peracidity in Walker carcinosarcoma 256-bearing Wistar rats attained by glucose (Gk) infusion was significantly (t-Test; p = 3.49) increased by a following infusion of 200 mg NAD in 7 ml 40 per cent. Gk-solution. The mean pH values obtained on six animals amounted 6.88 (start), 5.21 (after Gk) and 5.79 (after Gk + NAD). Three animals were cured through the hyperacidification process.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy*; D004357:Drug Synergism; D005947:Glucose / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006019:Glycolysis / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D009243:NAD / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D009243:NAD; D005947:Glucose
Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersäuerung in vivo durch NAD