[Localization of specific antigen in the organs of newborn animals vaccinated with liver smallpox vaccine].
Of 20 suckling rabbits, 4-5-days old, inoculated with live smallpox vaccine intradermally 6 displayed symptoms of generalized pox virus and neuroparalysis complications. Intensive accumulation of specific antigen in the brain, lungs, spleen, and the lymph glands was revealed by immunofluorescent method. The smallpox vaccine virus was isolated from these organs. Prolonged persistance of the attenuated smallpox virus was observed in the brain, spinal cord, lungs, spleen, and the lymph glands of 14 suckling rabbits showing no signs of any disease; specific antigen was revealed by immunofluorescent test. Vascular disturbances and slight cell changes were observed in the brain tissue of the inoculated animals. These changes were more severe in the sick animals.
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D010243:Paralysis / Q000209:etiology*; D011817:Rabbits; D012899:Smallpox / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000009:adverse effects*; D013116:Spinal Cord / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D014611:Vaccination; D012901:Variola virus / Q000302:isolation & purification
D000956:Antigens, Viral; D012900:Smallpox Vaccine
O lokalizatsii spetsificheskogo antigena v organakh novorozhdennykh zhivotnykh, privitykh zhivoĭ vaktsinoĭ protiv ospy.