Stimulated neutrophil locomotion: chemokinesis and chemotaxis.
All leukocytes are capable of responding chemotactically (oriented locomotion) and chemokinetically (stimulated nondirected or random locomotion) to a variety of chemical agents. A brief review of the in vitro and in vivo methods of studying neutrophil movement and our present knowledge of chemotactic factors is presented as well as a discussion on the mechanisms of stimulated movement. Two clinically important instances of defects in neutrophil movement, ie, the Chédiak-Higashi syndrome and a case of actin dysfunction, are herein described.
D001205:Ascorbic Acid / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002465:Cell Movement; D002609:Chediak-Higashi Syndrome / Q000097:blood; D002634:Chemotaxis, Leukocyte; D003176:Complement C3 / Q000494:pharmacology; D003182:Complement C5 / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D003584:Cytological Techniques; D003599:Cytoskeleton; D006801:Humans; D007249:Inflammation; D007610:Kallikreins / Q000494:pharmacology; D008247:Lysosomes / Q000648:ultrastructure; D008870:Microtubules; D009504:Neutrophils / Q000502:physiology* / Q000648:ultrastructure; D009842:Oligopeptides / Q000494:pharmacology; D010960:Plasminogen Activators / Q000494:pharmacology; D011955:Receptors, Drug; D012884:Skin Window Technique; D012964:Sodium / Q000378:metabolism; D013329:Structure-Activity Relationship
D003176:Complement C3; D003182:Complement C5; D009842:Oligopeptides; D011955:Receptors, Drug; D012964:Sodium; D000242:Cyclic AMP; D007610:Kallikreins; D010960:Plasminogen Activators; D006152:Cyclic GMP; D001205:Ascorbic Acid; D002118:Calcium