[Influence of methylcobalamin and cyanocobalamin on the neoplastic process in rats].
The effect of methylcobalamine (5.6-dimethylbenzimidazolyl-Co-methylcobamide, CH3-B12) and cyanocobalamine (5,6-dimethylbenzimidazolyly-Co-cyanocobamide, CN-B12) on the growth of Walker's carcinosarcoma and longevity of white noninbred rats with implanted Zajdela ascites hepatoma was studied. The two agents exerted a similar effect. They 1) reduced the survival of rats with implanted Zajdela ascites hepatoma and Walker's carcinosarcoma; 2) did not increase the cell concentration in ascites; and 3) increased the total volume of ascites.
D000818:Animals; D002273:Carcinogens; D002279:Carcinoma 256, Walker / Q000139:chemically induced*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D051381:Rats; D014805:Vitamin B 12 / Q000633:toxicity*
D002273:Carcinogens; D014805:Vitamin B 12
Vliiani metilkobalamina i tsiankobalamina na protsess neoplazii u krys.