Mechanism of protection from primary bovine viral diarrhea virus infection. I. The effects of dexamethasone.
A series of investigations was designed to study the role of cellular immunity and passive antibody in protecting neonatal calves from primary bovine viral diarrhea virus infection. Administration of corticosteroids (dexamethasone) in doses capable of suppressing cellular immunity markedly potentiated systemic bovine viral diarrhea virus infection in calves which lacked bovine viral diarrhea passive neutralizing antibody. Immunosuppressed calves did not form neutralizing antibody to bovine viral diarrhea virus and developed a fatal viremia. Calves with high levels of passive bovine viral diarrhea neutralizing antibodies were protected from the effect of corticosteroids. The results suggest an essential role for humoral passive antibody, but not for cellular immunity, in protection from primary systemic bovine viral diarrhea virus infection in calves.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003907:Dexamethasone / Q000627:therapeutic use*; D003967:Diarrhea / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D012328:RNA Viruses / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*
D000914:Antibodies, Viral; D003907:Dexamethasone