Possible role of infectious simian foamy virus DNA in persistent infection.
Simian foamy virus type 7 (SFV-7) can persist in peripheral blood leukocytes of SFV-7-infected rabbits. Rabbit peripheral blood leukoyctes cultured in vitro did not support the growth of SFV-7, but low titer of virus could be detected after 4 to 5 days incubation. The DNA derived from SFV-7 infected primary rabbit kidney cells is infectious. The presence of SFV-7 DNA provirus in infected rabbit kidney cells during replication may contribute one of the mechanisms of persistance.
D000818:Animals; D002908:Chronic Disease; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007962:Leukocytes / Q000382:microbiology; D011817:Rabbits; D012190:Retroviridae / Q000235:genetics / Q000302:isolation & purification; D016092:Spumavirus / Q000235:genetics / Q000302:isolation & purification; D014162:Transfection; D014777:Virus Diseases / Q000235:genetics*; D014779:Virus Replication
D004279:DNA, Viral