[Antihypoxic effect of analogs of cyclic adenosine monophosphate, phosphodiesterase inhibitors].
A number of investigated cAMP derivatives are shown to inhibit the cAMP-phosphodiesterase in brain tissues of white rats in vitro. The 8-substituted aminoethylamino-derivatives proved to be effective inhibitors of the enzyme. Among them the most pronounced inhibition displayed the 8-(beta-aminoethylamino)-cAMP. In an in vitro experiment on the model of hypoxic hypoxia in rats it was shown to possess strong anti-hypoxic properties. The possible prospective clinical use of the cAMP analogs--inhibitors of the cAMP-phosphodiesterase--is discussed.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D010726:Phosphodiesterase Inhibitors; D051381:Rats
D010726:Phosphodiesterase Inhibitors; D000242:Cyclic AMP
Antigipoksicheskiĭ éffekt analogov tsiklicheskogo adenozinmonofosfata--ingibitorov fosfodiésterazy.