Hapten-specific respiratory hypersensitivity in guinea pigs.
Respiratory hypersensitivity to small chemical determinants (haptens) was produced in guinea pigs by repeatedly exposing the animals to aerosols of hapten-ovalbumin conjugates. In this way, reactivity toward p-azobenzenearsonate and p-tolyl isocyanate was induced. Carrier (ovalbumin)-specific respiratory reactions were not produced. Hapten-specific respiratory hypersensitivity was accompanied by the production of hapten-specific antibodies. The method for inducing hapten-specific hypersensitivity can be applied to screen various industrial chemicals for their sensitizing abilities toward the respiratory tract.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001147:Arsanilic Acid / Q000633:toxicity; D004781:Environmental Exposure; D005260:Female; D006168:Guinea Pigs; D006241:Haptens / Q000276:immunology / Q000633:toxicity*; D010047:Ovalbumin / Q000633:toxicity; D012130:Respiratory Hypersensitivity / Q000139:chemically induced*; D014051:Toluene 2,4-Diisocyanate / Q000633:toxicity; D010132:p-Azobenzenearsonate / Q000633:toxicity
D000906:Antibodies; D006241:Haptens; D014051:Toluene 2,4-Diisocyanate; D010132:p-Azobenzenearsonate; D010047:Ovalbumin; D001147:Arsanilic Acid