[Discriminant-analytic structure-effect relationship of qualitative biological data. Virostatic effect of isatin-beta-isothiosemicarbazones].
"Yes/No" results from the plaque-diffusion inhibition test concerning the virostatic activity of substituted isatin-beta-isothiosemicarbazones against mengo- and vaccinia-viruses can be described discriminant analytically by means of simple substituent constants. The discriminant analysis permits quantitative structure-activity analysis of qualitative and semi-quantitative test data, thus offering a chance for theoretical synthesis optimization already at the level of rough screening.
D007211:Indoles / Q000494:pharmacology*; D007510:Isatin / Q000494:pharmacology*; D008574:Mengovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects*
D007211:Indoles; D013882:Thiosemicarbazones; D007510:Isatin
Diskriminanzanalytische Struktur-Wirkungs-Analyse bei qualitativen biologischen Daten. Virostatische Wirkung von Isatin-beta-isothiosemikarbazonen