Effect of (+)catechin on connective tissue.
The effect of (+)catechin on connective tissue was studied in organ cultures of chick embryo tibiae and after in vivo injection in rats and mice. Collagen biosynthesis and hydroxylation of 14C-Pro-labelled protocollagen in vitro by protocollagen proline hydroxylase (PPH) were inhibited. In vivo, a slight decrease in the biosynthesis of collagen and in the PPH activity in skin of rats and mice was noticed as an effect of (+)catechin. No effect of the drug was observed on the incorporation of 14C-D-glucosamine by chick embryo tibiae. Increased urinary excretion of acid mucopolysaccharide metabolites by the mice injected with (+)catechin was observed.
D000629:Aminopropionitrile / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002392:Catechin / Q000494:pharmacology*; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis; D006900:Hydroxylation; D006909:Hydroxyproline / Q000096:biosynthesis; D007501:Iron / Q000378:metabolism; D008297:Male; D051379:Mice; D009088:Mucoproteins / Q000096:biosynthesis; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors; D011392:Proline / Q000096:biosynthesis; D051381:Rats
D001578:Benzopyrans; D002250:Carbon Radioisotopes; D006023:Glycoproteins; D009088:Mucoproteins; D000629:Aminopropionitrile; D003300:Copper; D002392:Catechin; D003094:Collagen; D011392:Proline; D007501:Iron; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline