title: Disruption of multicellular organization in the cellular slime molds by cyclic AMP.
abstract: Addition of cyclic AMP causes disorder in the multicellular stage of a number of species of cellular slime molds. In those which produce fruits with cellular stalks, the addition of cyclic AMP stimulates prestalk cells to differentiate into mature stalk cells. Prespore cells do not differentiate into spores under the influence of cyclic AMP, most degenerate and seem to die. I hypothesize that the normal course of differentiation from vegetative cells is one leading to spores, but that cyclic AMP can divert this course to one leading to the stalk cell. Dibutyryl cyclic AMP, cyclic GMP and cyclic AMP disrupt slugs of Polysphondylium pallidum, while species of Dictyostelium are disrupted by only cyclic AMP. The multicellular stage of P. violaceum is unaffected by high concentrations of exogenous cyclic nucleotides. Cell organization of Acytostelium ellipticum, a species with an acellular stalk, was disrupted by cyclic AMP, but no stalk cells were formed; only spores.
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology; D004023:Dictyostelium / Q000166:cytology / Q000187:drug effects; D006150:Guanine Nucleotides / Q000494:pharmacology; D009235:Myxomycetes / Q000166:cytology / Q000187:drug effects*; D013045:Species Specificity; D013172:Spores, Fungal
chemical_list: D000227:Adenine Nucleotides; D006150:Guanine Nucleotides; D003994:Bucladesine; D000242:Cyclic AMP; D006152:Cyclic GMP