Salivary neutralizing activity against herpes simplex virus type 1.
Samples of saliva collected from 40 patients, of whom 16 had a previous clinical history of herpes simplex virus type 1 (HSV-1) infection, were concentrated and sterilized. Salivary neutralizing activity, as measured by a plaque-reduction method, was found in 62% of those patients with a history of oral lesions. Studies with antisera to human immunoglobulin indicated that the IgG class of immunoglobulin was a major HSV-1-neutralizing component of both saliva and serum.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests / Q000379:methods; D012463:Saliva / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*
D000914:Antibodies, Viral