Membranous nephropathy long-term follow-up and association with neoplasia.
A ten years follow-up has been made on 66 patients with membranous glomerulonephritis. Eighty per cent of them showed nephrotic syndrome, one third elevated diastolic pressure and in 50% of the patients the GFR was reduced. Histopathologic stating and evolution were made as described by Ehrenreich histology with clinic and prognosis. Seven of 76 cases (11%) showed association with neoplasia; different pathogenetic hypothesis could be risen by this observation. The five year survival was 84% and the ten year survival about 50%. Increasing age and the presence of nephrotic syndrome mainly contribute to a poor prognosis.
D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000209:etiology; D003110:Colonic Neoplasms / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications*; D006689:Hodgkin Disease / Q000209:etiology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D009404:Nephrotic Syndrome / Q000209:etiology; D011379:Prognosis; D012004:Rectal Neoplasms / Q000209:etiology; D009396:Wilms Tumor / Q000209:etiology