Induction of melanogenesis in the epidermal melanoblasts of newborn mouse skin by MSH.
The number of melanocytes positive to the dopa reaction in the epidermis was shown to increase after newborn mice were injected with alpha-MSH or DBc-AMP. The agents seemed to induce the initiation of melanogenesis in the pre-existing melanoblasts. Electron-microscopic observation also demonstrated that alpha-MSH induced not only maturation of melanosomes but also the formation of melanosomes.
D000818:Animals; D000831:Animals, Newborn; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D008543:Melanins / Q000096:biosynthesis*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D008544:Melanocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D008543:Melanins; D003994:Bucladesine; D009074:Melanocyte-Stimulating Hormones