Adjuvant chemotherapy in lung cancer: review and prospects.
The results of trials testing combined surgery and chemotherapy in lung cancer are reviewed. Fifteen adjuvant trials using various chemotherapeutic agents were analyzed to determine reasons for their lack of success. Current trials with adjuvant therapy in lung cancer are briefly outlined. In addition, analysis of the activity of chemotherapeutic agents in advanced lung cancer and its implications in the design of future adjuvant studies are detailed.
D000230:Adenocarcinoma / Q000628:therapy; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D012107:Research Design; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D008466:Mechlorethamine; D014747:Vinblastine; D003520:Cyclophosphamide