title: Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae.
abstract: Methyl methanesulfonate (MMS)-sensitive mutants of Saccharomyces cerevisiae belonging to four different complementation groups, when homozygous, increase the rate of spontaneous mitotic segregation to canavanine resistance from heterozygous sensitive (canr/+) diploids by 13-to 170-fold. The mms8-1 mutant is MMS and X-ray sensitive and increases the rate of spontaneous mitotic segregation 170-fold. The mms9-1 and mms13-1 mutants are sensitive to X rays and UV, respectively, in addition of MMS, and increase the rate of spontaneous mitotic segregation by 13-fold and 85-fold, respectively. The mutant mms21-1 is sensitive to MMS, X rays and UV and increases the rate of spontaneous mitotic segregation 23-fold.
mesh_terms: D002172:Canavanine / Q000494:pharmacology; D004260:DNA Repair; D004277:DNA, Single-Stranded; D004352:Drug Resistance, Microbial / Q000528:radiation effects; D005816:Genetic Complementation Test; D008540:Meiosis; D008698:Mesylates / Q000494:pharmacology*; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014965:X-Rays
chemical_list: D004277:DNA, Single-Stranded; D008698:Mesylates; D002172:Canavanine; D008741:Methyl Methanesulfonate