Effects of ethylnitrosourea administration during pregnancy on three subsequent generations of BDVI Rats.
A single dose of 40 mg/kg of N-nitrosoethylurea (ENU) was administered to BDVI rats on the 16th day of pregnancy. The first generation descendants (F1) were mated on a brother-to-sister system to produce a second generation (F2) which was then mated to produce a third generation. A high incidence of nervous tissue tumors and a few kidney tumours were observed in F1 descendants. A few nervous tissue tumours were observed in F3 but not in F2 descendants. These results partially confirm previous observations obtained with 7,12-dimethylbenz(a)anthracene in mice and nitrosomethylurea in rats and indicate that prenatal exposure to a chemical carcinogen may result in an increased cancer risk which can persist for more than one generation.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000235:genetics; D008297:Male; D008431:Maternal-Fetal Exchange; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000235:genetics; D009380:Neoplasms, Nerve Tissue / Q000139:chemically induced / Q000235:genetics; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea