[Virilizing adrenal cortical tumors in childhood (author's transl)].
We report on four patients, aged seven months to seven years, with virilizing adrenal cortical tumors. Diagnosis was made by clinical and laboratory data. Tumor localisation was achieved preoperatively in three patients. In two patients both androgen and glucocorticoid excretion were elevated. In three patients histological examination showed a carcinoma, in one patient an adenoma was suggested. There were no metastases. In two patients surgical removal was followed by cytostatic therapy, in one of them additional irradiation treatment was carried out. This child died 10 1/2 years later from a metastasizing renal cell carcinoma which originated from the kidney being situated in the irradiated area.
D015068:17-Ketosteroids / Q000652:urine; D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery / Q000652:urine; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000652:urine; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000652:urine; D006801:Humans; D007223:Infant; D008297:Male
D015068:17-Ketosteroids; D005938:Glucocorticoids
Virilisierende Nebennierenrindentumoren im Kindesalter. Diagnostische und therapeutische Besonderheiten.