X-linked and autosomal genes controlling mouse alpha-galactosidase expression.
Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse alpha-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of alpha-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D003433:Crosses, Genetic; D005260:Female; D005696:Galactosidases / Q000235:genetics*; D005809:Genes, Regulator; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D012730:Sex Chromosomes; D014960:X Chromosome; D000519:alpha-Galactosidase / Q000235:genetics*
D005696:Galactosidases; D000519:alpha-Galactosidase