The effect of N-nitrosobis(2-oxopropyl)amine after oral administration to hamsters.
Oral administration of N-nitrosobis(2-oxopropyl)amine (BOP) in drinking water to Syrian golden hamsters for 90 days resulted in a high incidence of intra- and extrahepatic bile duct neoplasms. Only a few pancreatic neoplasms and no lung and kidney tumors developed, in contrast to results obtained after subcutaneous BOP administration.
D002759:Adenoma, Bile Duct / Q000139:chemically induced; D000284:Administration, Oral; D000818:Animals; D001650:Bile Duct Neoplasms / Q000139:chemically induced*; D001653:Bile Ducts, Intrahepatic; D006224:Cricetinae; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000008:administration & dosage* / Q000633:toxicity; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000139:chemically induced
D009602:Nitrosamines