Cytomegalovirus pneumonia after treatment with melphalan and prednisone. Report of a case.
A patient with multiple myeloma had pancytopenia after treatment with melphalan and prednisone and died of an interstitial pneumonia. Post-mortem examinations showed cytomegalic cells in the lungs. Lung tissue showed a high titer of cytomegalovirus. Only when other causes have been ruled out by microbiologic, serologic, and histologic examinations should melphalan be believed to cause respiratory illness.
D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D011024:Pneumonia, Viral / Q000209:etiology* / Q000473:pathology; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use
D008558:Melphalan; D011241:Prednisone