Cellular transformation and the 'morphologic phenotype' of transformed cells.
Expression of the product of the transforming gene (src) of RNA tumour viruses promotes growth and usually alters the adhesion, appearance and surface properties of cultured fibroblasts. The latter group of properties termed the 'morphologic phenotype' of transformed cells is largely due to diminished cell-to-substratum adhesion. The role of cyclic AMP, cell surface protein (CSP), and other factors in producing the 'morphologic phenotype' are discussed. The effects of src expression bear a striking resemblance to the action of peptide hormones such as insulin on appropriate target cells.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D002448:Cell Adhesion; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003260:Contact Inhibition; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism*; D003599:Cytoskeleton / Q000473:pathology; D005814:Genes, Viral; D007328:Insulin / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008871:Microvilli / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D013045:Species Specificity; D014764:Viral Proteins / Q000502:physiology
D007328:Insulin; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D010750:Phosphoproteins; D014764:Viral Proteins; D000242:Cyclic AMP; D011494:Protein Kinases