Establishment of an Epstein-Barr virus-determined nuclear antigen-negative human B-cell line from acute lymphoblastic leukemia.
A human B-cell line designated as BALL-1 was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). Neither Epstein-Barr virus (EBV) particles nor EBV-determined nuclear antigen (EBNA) was detectable. The morphologic and growth characteristics were clearly distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. BALL-1 cells probably originated from the donor's leukemia cells as judged from their cytogenetic, morphologic, and surface features. The BALL-1 line was the first EBNA-negative B-cell line established from ALL.
D000956:Antigens, Viral; D001402:B-Lymphocytes / Q000382:microbiology* / Q000473:pathology; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002467:Cell Nucleus / Q000276:immunology / Q000382:microbiology; D002869:Chromosome Aberrations; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology
D000956:Antigens, Viral