Benign liver-cell adenoma associated with long-term administration of an androgenic-anabolic steroid (methandienone).
A 19-year-old man with paroxysmal nocturnal hemoglobinuria treated for 3 years with Methandienone was admitted to the hospital with hemoperitoneum due to the rupture of an hepatic tumor. Histology revealed that it was a benign liver cell adenoma, with a pathologic appearance and mode of clinical presentation closely resembling those of cases observed to develop in association to contraceptive steroids.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D006457:Hemoglobinuria, Paroxysmal / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008696:Methandrostenolone / Q000009:adverse effects*
D008696:Methandrostenolone