Corneal donor material selection.
Histologic study of eyes used as donor material for corneal transplant revealed one instance of massive leukemic infiltration with leukemic keratic precipitates on the fellow eye. In another eye, microabscesses composed of acute and chronic inflammatory cells containing Crytococcus neoformans were present. In a third patient metastatic anaplastic cells were present in the choroid. We think donor eyes are absolutely unacceptable if death was caused by any chronic neurologic disorder, unless clearly secondary to trauma. Eyes from patients with septecimia, hepatitis, jaundice and any evidence of any active viral infection, syphilis, and positive serology are also unacceptable. Extreme caution should be used in selecting eyes of patients with ocular or systemic malignancy, long-term diseases, particularly if immunosuppressive agents were used, where a history of eye disease exists, including corneal disease or dystrophy, iritis, absolute glaucoma or acute glaucoma, and eyes with a history of previous intraocular surgery.
D001424:Bacterial Infections / Q000150:complications / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation; D005123:Eye / Q000473:pathology; D005909:Glioblastoma / Q000150:complications; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008875:Middle Aged; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods*