title: [Electron-cytochemical and morphometric study of the activity of several enzymes in thyrocyte metochondria during malignant degeneration].
abstract: Cytochrome oxidase and succinic dehydrogenase activities were studied in the mitochondria of rat thyroid cell during experimental malignization by means of the electron-cytochemical and morphometric methods. The activity of these enzymes in the mitochondria changed depending on the stage of malignization: at the early stages it approached the normal activity, and at the later stages (precancer)--it decreased and approached the mitochondrial activity of cancer cells. A sharp decrease in the activity of the enzymes under study in the morphologically changed mitochondria of cancer cells may characterize their qualitative changes.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000201:enzymology* / Q000648:ultrastructure; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006651:Histocytochemistry; D006965:Hyperplasia / Q000201:enzymology; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000201:enzymology* / Q000648:ultrastructure
chemical_list: D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV
vernacular_title: Elektronno-tsitokhimicheskoe i morfometricheskoe issledovanie aktivnosti nekotorykh fermentov v mitokhondriiakh tireotsitov v protesesse malignizatisii