Moenomycin: an inhibitor of c55-isoprenoid-alcohol kinase from Staphylococcus aureus.
The effect of a variety of structurally diverse antibiotics on C55-isoprenoid-alcohol kinase (EC 2.7.1.66) from Staphylococcus aureus has been examined. Only moenomycin was found to be inhibitory (Ki = 0.2 mM). Moenocinol, the C25 lipid component of moenomycin, did not serve as a substrate of the kinase reaction and was less inhibitory than the intact antibiotic. It is concluded that the observed inhibition may be due to the structural similarity between C55-isoprenylmonophosphate and the substituted moenocinol moiety of moenomycin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005233:Fatty Alcohols; D006017:Glycolipids / Q000494:pharmacology; D007700:Kinetics; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D017853:Phosphotransferases (Alcohol Group Acceptor); D013211:Staphylococcus aureus / Q000201:enzymology*; D013729:Terpenes
D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols; D006017:Glycolipids; D013729:Terpenes; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C021454:undecaprenol kinase