Inefficient humoral immune response of lymphoma-prone wild mice to persistent leukemia virus infection.
Adult wild mice (LC) from a natural colony with a high incidence of spontaneous lymphomas had free infectious virus in their seara (average 10(3.5) infectious units/ml) and parenchymal organs (average 10(5.2) infectious units/g tissue). They did not have detectable levels of free virus-specific antibodies that could be demonstrated by virus neutralization or immunofluorescence at higher than a 1:10 dilution. Only 5 of 28 animals had free antibodies detectable by radioimmunoprecipitation assay, and tissues of 4 mice also had nondetectable levels of virus determined by infectivity assay. Formalized vaccine from the indigenous virus did not induce production of virus-neutralizing antibodies or protect against naturally occurring disease. The animals with persistent leukemia virus infection, however, elicited good humoral immune responses to virus-unrelated antigen.
D000818:Animals; D000906:Antibodies; D000914:Antibodies, Viral; D000937:Antigen-Antibody Reactions; D001853:Bone Marrow / Q000382:microbiology; D004912:Erythrocytes / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000382:microbiology
D000906:Antibodies; D000914:Antibodies, Viral