Comparison of carcinogenicity of N-alkyl-N'-nitro-N-nitroso-guanidines.
Carcinogenicity of seven homologs of N-alkyl-N'-nitrosoguanidine (N-alkyl-NNG), namely, N-methyl-NNG, N-propyl-NNG, N-butyl-NNG, N-isobutyl-NNG, N-pentyl-NNG, and N-hexyl-NNG, was examined by injecting the compounds subcutaneously into rats. All of them except N-isobutyl-NNG and N-hexyl-NNG were carcinogenic, but N-ethyl-NNG followed by N-methyl-NNG were stronger carcinogens than those with longer alkyl chains.
D000818:Animals; D002273:Carcinogens; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D006394:Hemangiosarcoma / Q000139:chemically induced / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000139:chemically induced / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity; D009604:Nitrosoguanidines / Q000633:toxicity; D051381:Rats; D012208:Rhabdomyosarcoma / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; D009604:Nitrosoguanidines