title: Inhibitory effects of cyclic AMP on vasopressin release from the rat neural lobe in vitro.
abstract: The basal release of vasopressin from the isolated neural lobe of the rat decreased in the presence of exogenous cAMP, 8Br-cAMP, diB-cAMP, theophylline, SQ 20,009 and RO20-1724. The concentration-related decrease in vasopressin release, in the presence of phosphodiesterase inhibitors, was accompanied by a progressive increase in cAMP concentration in the neural lobe. The findings suggest a local modulation of vasopressin release from the neural lobes.
mesh_terms: D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004974:Etazolate / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D014667:Vasopressins / Q000378:metabolism*; D014970:Xanthines / Q000494:pharmacology
chemical_list: D014970:Xanthines; D014667:Vasopressins; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D002110:Caffeine; D003994:Bucladesine; D010208:Papaverine; D000242:Cyclic AMP; D004974:Etazolate