Watery diarrhoea syndrome with episodic hypercalcaemia.
A patient with the Watery-Diarrhoea syndrome and episodic hypercalcaemia is reported. Plasma levels of vasoactive intestinal peptide (VIP) were elevated, and an islet cell adenoma of the pancreas was removed following which VIP levels decreased and diarrhoea ceased. During a hypercalcaemic episode, serum parathyroid hormone (PTh) levels were suppressed indicating the hypercalcaemia was independent of PTh and probably due to a direct action of VIP on calcium turnover.
D007516:Adenoma, Islet Cell / Q000097:blood / Q000150:complications*; D003967:Diarrhea / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications*; D010281:Parathyroid Hormone / Q000097:blood; D013577:Syndrome; D014660:Vasoactive Intestinal Peptide / Q000097:blood
D010281:Parathyroid Hormone; D014660:Vasoactive Intestinal Peptide