Effect of praseodymium nitrate on hepatocytes and Kupffer cells in the rat.
Intravenous administration of the rare earth metal salt, praseodymium nitrate, induced hepatic damage in the rat, as assessed by morphologic examination (light and electron microscopy) and biochemical parameters (serum glutamic-pyruvic transaminase (EC 2.6.1.2) and glutamic-oxalacetic transaminase (EC 2.6.1.1) activity as well as hepatic triglyceride content). Praseodymium hepatotoxicity was only attained with lower doses (10, 20, or 40 mg/kg), whereas a larger dose (80 mg/kg) was inactive in this respect. As detected by electron microscopy, lower doses of the metal salt caused hepatocytic alterations consisting of degranulation and dilatation of rough endoplasmic reticulum, accumulation of smooth endoplasmic reticulum as well as numerous lipid droplets. No abnormalities were detected in the cell organelles following administration of a large dose of the metal salt; however, vacuoles containing markedly electron-dense material were seen in the cytoplasm of the hepatocytes and the sinusoidal Kupffer cells.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D002479:Inclusion Bodies / Q000648:ultrastructure; D007728:Kupffer Cells / Q000187:drug effects*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D011221:Praseodymium / Q000633:toxicity*; D051381:Rats; D012737:Sex Factors
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011221:Praseodymium