Endometrial carcinoma and oral contraceptive agents.
Six patients who took oral contraceptive agents for 5 to 18 years developed endometrial neoplasia. Endometrial adenocarcinoma occurred in 4 of these patients and severe adenomatous hyperplasia occured in 2. Five of the 6 patients took sequential agents; 1 patient used a combined agent. An additional patient who took Premarin and Provera sequentially developed adenocarcinoma of the endometrium. Eighteen cases of endometrial adenocarcinoma and 7 cases of adenomatous hyperplasia in patients with long-term sequential oral contraceptive use have previously been reported by others. Progestogens may not be completely protective against the endometrial cancer-causing potential of the estrogens, especially in the sequential regimens.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003279:Contraceptives, Oral, Sequential / Q000008:administration & dosage / Q000009:adverse effects; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D004116:Dimethisterone / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000009:adverse effects; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009644:Norgestrel / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced*
D003276:Contraceptives, Oral; D003279:Contraceptives, Oral, Sequential; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D004966:Estrogens, Conjugated (USP); D009644:Norgestrel; D004997:Ethinyl Estradiol; D008525:Medroxyprogesterone; D004116:Dimethisterone