Effect of sodium nitroprusside and trimetaphan on neuromuscular transmission in the frog.
In summary, it appears from this and other studies that trimetaphan has the potential for producing neuromuscular blockade when used in large doses or when combined with other muscle relaxants. The mode of action appears to be principally that of non-depolarizing neuromuscular blockade. Sodium nitroprusside, on the other hand, even in doses beyond these accepted clinically, does not affect neuromuscular transmission and unless otherwise contraindicated is safe to use with muscle relaxants.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D005292:Ferricyanides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008839:Microelectrodes; D009045:Motor Endplate / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D009599:Nitroprusside / Q000494:pharmacology*; D011894:Rana pipiens; D009435:Synaptic Transmission / Q000187:drug effects*; D014294:Trimethaphan / Q000494:pharmacology*
D005292:Ferricyanides; D009599:Nitroprusside; D014294:Trimethaphan; D000109:Acetylcholine