Absorption and biotransfomation of cholecalciferol in drug-induced osteomalacia.
The gastrointestinal absorption of vitamin D3 and its biotransformation to 25-hydroxycholecalciferol was studied in patients with drug-induced osteomalacia. The mean coefficient of absorption was virtually identical in the drug-treated group (82.8%) and the control (83.8%). The biotransformation of vitamin D3 to 25-hydroxycholecalciferol was significantly accelerated (P less than 0.03) in the drug-treated group compared to the control group. These data suggest that vitamin D absorption is not significantly altered but that biotransformation of vitamin D3 to 25-hydroxycholecalciferol is accelerated in drug-induced osteomalacia.
D000293:Adolescent; D000328:Adult; D001711:Biotransformation; D002648:Child; D002762:Cholecalciferol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D010018:Osteomalacia / Q000139:chemically induced / Q000378:metabolism*
D002762:Cholecalciferol