Transformation by concanavalin A of the response of molluscan neurones to L-glutamate.
Concanavalin A causes in all Aplysia and Helix neurones a depolarising response to L-glutamate. The Con A-induced glutamate response is pharmacologically distinct from the three cell-specific glutamate responses (two inhibitory, one excitatory) that can be elicited from untreated molluscan neurones. The transformation in glutamate sensitivity brought about by Con A does not seem to be related to the lectin's capacity to produce redistribution of receptor sites in cell membranes.
D000818:Animals; D001048:Aplysia; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D012964:Sodium / Q000494:pharmacology; D013237:Stereoisomerism; D013696:Temperature
D002712:Chlorides; D005971:Glutamates; D017981:Receptors, Neurotransmitter; D003208:Concanavalin A; D012964:Sodium