Cultured heart cell reaggregate model for studying cardiac toxicology.
This review represents a summary of the technique of using cultured heart cells as a model system for studying the physiology, pharmacology, biochemistry and toxicology of myocardial cells. The general techniques and types of culture preparations commonly used are given and some of the advantages and disadvantages of working with cultured heart cells are summarized.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001808:Blood Vessels / Q000166:cytology; D002449:Cell Aggregation; D002469:Cell Separation; D002478:Cells, Cultured; D002642:Chick Embryo; D046508:Culture Techniques; D000242:Cyclic AMP / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000196:embryology; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D008722:Methods; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D009210:Myofibrils / Q000648:ultrastructure; D009924:Organ Culture Techniques; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology
D007473:Ion Channels; D013779:Tetrodotoxin; D012964:Sodium; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium