[Relationship between group G chromosomes, especially chromosome 21, and the sensitivity of human cells to Coxsackie B viruses].
The R-method of differential chromosome staining by length was applied to comparative karyological studies on the culture of J 96 human cells susceptible to enteroviruses, and on the J 41 cell line derived from this culture and possessing high specific resistance to Coxsackie B viruses. Karyotype of the J 41 cell line was shown to be deprived of chromosome G21 (P less than 0.0001). The number of other chromosomes varied from cell to cell, but they are constantly present in the majority of cells of both the J 96 and J 41 cell lines. A conclusion is drawn that chromosome G21 incorporates gene(s) which controls the human cells susceptibility to Coxsackie B viruses.
D002460:Cell Line; D002874:Chromosome Mapping; D002904:Chromosomes, Human, 21-22 and Y; D029822:Enterovirus B, Human / Q000472:pathogenicity*; D005802:Genes, MHC Class II; D006801:Humans
Sviaz' khromosom gruppy G, v chastnosti 21-i khromosomy, s chuvstvitel'nost'iu chelovecheskikh kletok k virusam Koksaki B.