Biological damage in testis by iodine-125 in partially blocked thyroid of rats.
Degeneration of testis has been observed after administration of Iodine-125 in potassiumperchlorate treated rats. Histological damage is associated with loss of DNA, RNA, acid phosphatase, total adenosine triphosphatase (ATPase) and Na/K dependent ATPase. Iodine-125 induced atrophic testis shows higher content of sodium and lower levels of potassium as compared to control testis. Damage of testis by Iodine-125 has been compared with atrophied testis, following gamma irradiation earlier reported. Auger effect due to Iodine-125 decay and transmutation at the sites of nuclei and plasma membrane of germinal cells seems to be the possible explanation for testicular damage caused by Iodine-125.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D007457:Iodine Radioisotopes; D008297:Male; D010472:Perchlorates / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013091:Spermatogenesis / Q000528:radiation effects; D013737:Testis / Q000378:metabolism / Q000528:radiation effects*; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*
D007457:Iodine Radioisotopes; D010472:Perchlorates; D012964:Sodium; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D011188:Potassium