[Serum lactic dehydrogenase isoenzymes in metastatic and primary liver carcinoma (author's transl)].
Serum LDH isoenzymes were comparatively evaluated in experimental and human liver carcinoma. In our experimental studies, LDH4 increased in AH 66 F metastatic hepatic cancer, but DAB hepatic cancer showed a significant increase of LDH5. In clinical studies, LDH4 and LDH5 increased significantly in metastatic liver carcinoma, and 15 (79%) out of 19 cases showed higher values of LDH4. In primary liver carcinoma LDH5 increased significantly, and 12 (92%) out of 13 cases showed a higher LDH5. Therefore, analyses of serum LDH isoenzymes would aid in differential diagnosis of metastatic and primary liver carcinoma.
D000818:Animals; D001201:Ascites / Q000097:blood; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008113:Liver Neoplasms / Q000175:diagnosis*; D009362:Neoplasm Metastasis; D051381:Rats
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
LDH-Isoenzymmuster bei Hepatom und Metastasenleber