Cell-mediated cytotoxicity: comparison of primary and secondary immune reactions after parainfluenza type 1 virus inoculation.
H-2 antigen compatibility of effector spleen cells and target cells was necessary for cell-mediated cytotoxicity (CMC) after both 1 and 2 intraperitoneal inoculation of 6/94 virus into mice. T cells were responsible for both primary and secondary CMS reactions. Neither reaction was influenced by the presence of virus-specific antibody added to the test system. Secondary CMC peaked earlier than the primary response and declined more rapidly. In vitro stimulation of primed spleen cells could also be used to detect the secondary CMC response.
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000008:administration & dosage; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006183:H-2 Antigens