Adriamycin cardiotoxicity in children: case reports, literature review, and risk factors.
Two children with Wilms' tumor and prior thoracic radiation developed congestive heart failure at cumulative adriamycin doses of 350 mg/m2 and 400 mg/m2. Details of these two cases and a summary of previously reported adriamycin cardiotoxicity in children are presented. Dose recommendations and predictive tests are discussed.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D011832:Radiation Injuries / Q000209:etiology; D011838:Radiation-Sensitizing Agents; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012306:Risk; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy
D011838:Radiation-Sensitizing Agents; D004317:Doxorubicin