Progressive multifocal leukoencephalopathy: failure of response to transfer factor and cytarabine.
A 57-year-old woman with a 2-year history of neurologic symptoms was shown on brain biopsy to have progressive multifocal leukoencephalopathy. Although cell-mediated immune mechanisms were impaired, no underlying disease was found. The administration of transfer factor enhanced cell-mediated immunity, but the neurologic symptoms did not improve. Separate courses of glucocorticoids and cytarabine were associated with rapid neurologic deterioration.
D000324:Adrenocorticotropic Hormone / Q000009:adverse effects; D001921:Brain / Q000473:pathology; D003561:Cytarabine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007968:Leukoencephalopathy, Progressive Multifocal / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D014165:Transfer Factor / Q000627:therapeutic use*
D014165:Transfer Factor; D003561:Cytarabine; D000324:Adrenocorticotropic Hormone