title: Activity of acid hydrolases in skeletal muscle of untrained, trained and detrained mice of different ages.
abstract: The activities of p-nitrophenylphosphatase, beta-glucuronidase and beta-N-acetylglucosaminidase from crude skeletal muscle homogenates of 4 and 7 months old mice were assayed after short-term intensive and long-term moderate training and after terminated training. In the older untrained mice the activity of the hydrolases was higher than in the younger mice. The level increased with training and this increase was far more pronounced in the older animals. Cessation of training for 7 and 21 days decreased this activity in the older animals but it was again increased 42 days later and close to the level observed in the trained mice. In young mice 3 days' terminated training increased the activity of the acid hydrolases above the level of the trained animals but after additional 4 and 11 days' terminated training the activity decreased to slightly below that of the trained mice. The changes were most prominent in the activity of beta-glucuronidase and to a lesser extent in that of beta-N-acetylglucosaminidase while p-nitrophenylphosphatase activity was almost unaffected by training or terminated training. The effects of terminated training can be intepreted as representing altered catabolic processes in the turn-over of tissue components of skeletal muscle.
mesh_terms: D009597:4-Nitrophenylphosphatase / Q000378:metabolism*; D000118:Acetylglucosaminidase / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D005966:Glucuronidase / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism*; D051379:Mice; D009132:Muscles / Q000201:enzymology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D005082:Physical Exertion
chemical_list: D010744:Phosphoric Monoester Hydrolases; D009597:4-Nitrophenylphosphatase; D006596:Hexosaminidases; D005966:Glucuronidase; D000118:Acetylglucosaminidase