title: [Combined vaccines including 1 or several anti-foot-and-mouth valences].
abstract: Combined vaccines are used  for many human and animal diseases. However, we have very few examples of combinations containing anti-foot-and-mouth valence which would allow easy immunization against differnet diseases without additional handling. Until now foot-and-mouth vaccination has been applied simultaneously with anti-brucellic vaccination (Baldoni, Renoux), andi-anthrax (Nobili) and vaccination against swine fever and Aujeszky's disease (Lysenko). During the last ten years we have particularly studied the association of anti-foot-and-mouth disease vaccines with anti-brucella and anti-rabies vaccines. We have shown the possiblity of combining these different antigens, either in classical aqueous vaccines in aluminum hydroxide, or in emulsified vaccines containing oily adjuvants. The anti-brucella valences may be agglutinogenic (H 38) or non-agglutinogenic (MacEwen 45/20). The combined vaccines "rabies + foot-and-mouth disease" and "brucellosis + foot-and-mouth disease" can be produced on an industrial scale. For many years millions of animals have been successfully vaccinated in France by means of a combined "rabies + foot-and-mouth disease" vaccine.
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000536:Aluminum Hydroxide / Q000008:administration & dosage; D000818:Animals; D005537:Aphthovirus / Q000276:immunology*; D002004:Brucella Vaccine / Q000008:administration & dosage; D002003:Brucella abortus / Q000276:immunology; D002007:Brucellosis, Bovine / Q000517:prevention & control; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control; D005536:Foot-and-Mouth Disease / Q000517:prevention & control; D009821:Oils / Q000008:administration & dosage; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary; D011819:Rabies Vaccines / Q000008:administration & dosage; D012503:Saponins / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D002004:Brucella Vaccine; D009821:Oils; D011819:Rabies Vaccines; D012503:Saponins; D014765:Viral Vaccines; D000536:Aluminum Hydroxide
vernacular_title: Vaccins associés comportant une ou plusieurs valences antiaphteuses.