Mitogenic andadjuvant activities of polysaccharides from the cellular slime mold, Dictyostelium discoideum NC-4.
Cell surface and extracellular polysaccharide fractions obtained from Dictyostelium discoideum NC-4 cultured in bacteria-free medium showed strong B-cell mitogenic activities. Upon periodate treatment of the extra-cellular polysaccharide fraction this activity completely disappeared. The extracellular polysaccharide fraction could also enhance the antibody response in vitro against sheep red blood cells.
D000276:Adjuvants, Immunologic; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D004023:Dictyostelium; D004912:Erythrocytes / Q000276:immunology; D037102:Lectins; D008297:Male; D051379:Mice; D009235:Myxomycetes; D010504:Periodic Acid; D011134:Polysaccharides / Q000494:pharmacology*; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013936:Thymidine / Q000378:metabolism
D000276:Adjuvants, Immunologic; D037102:Lectins; D011134:Polysaccharides; D010504:Periodic Acid; D013936:Thymidine