Identification of a 30S RNA with properties of a defective type C virus in murine cells.
A novel species of 30S RNA has been detected in a variety of mouse cell lines. The 30S RNA is specifically packaged by helper-independent type C viruses propagated in such cells. Nucleic acid hybridization detects no homology between the 30SRNA and the genomic RNA of helper-independent mouse type C viruses. The properties of the 30S RNA suggest that it is a defective endogenous mouse type C virus and that it is analogous to a previously described class of defective endogenous rat type C virus, which has been shown previously to be the progenitor of Kirsten and Harvey murine sarcoma viruses.
D000818:Animals; D002460:Cell Line; D003673:Defective Viruses / Q000032:analysis*; D017988:Gammaretrovirus / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis*; D012190:Retroviridae / Q000032:analysis*; D014158:Transcription, Genetic
D012367:RNA, Viral