[Preliminary data on the protective effect of interferon coupled with liposomes in the mouse-virus model of murine hepatitis].
In MHV3-infected Balb/c mice the antiviral effect of murine interferon could be significantly enhanced by way of entrapment in cationic liposomes; these multi-lamellar spherules, made of egg lecithin, stearylamine and cholesterol, are supposed to exert a target effect leading to a greater accumulation of interferon in the liver and spleen. The possible use of liposomes as vectors of interferon in different viral pathologies is discussed.
D000818:Animals; D004195:Disease Models, Animal; D006524:Hepatitis, Viral, Animal / Q000517:prevention & control*; D007372:Interferons / Q000627:therapeutic use*; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D006517:Murine hepatitis virus
D008081:Liposomes; D007372:Interferons
Données préliminaires sur l'effet protecteur de l'interféron couplé à des liposomes dans le modèle souris-virus de l'hépatite murine.