Spontaneous lymphosarcoma arising in a nude mouse: characterization in vivo and in vitro.
A lymphosarcoma spontaneously arising in a nude mouse and a continuous cell line (NML-1) derived from it are described and compared. The primary tumor and a transplantable tumor line from it were composed of lymphoid cells, with no C-type viral particles seen by electron microscopy. The culture line was composed of cells with morphologic and functional properties of macrophages; budding C-type particles were abundant. The cells in the tumors produced in nude mice by injection of the NML-1 cells also resembled macrophages morphologically rather than lymphocytes; however, by electron microscopy, no C-type particles were seen. The findings suggest some type of in vivo suppression of complete expression of the virus.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D005260:Female; D007181:Inclusion Bodies, Viral; D008214:Lymphocytes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012190:Retroviridae / Q000648:ultrastructure; D012513:Sarcoma, Experimental / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D014184:Transplantation, Homologous