Hexoprenaline: beta-adrenoreceptor selectivity in isolated tissues from the guinea-pig.
1. A catecholamine beta-adrenoreceptor agonist, hexoprenaline, was examined in vitro on five guinea-pig tissues and its potency relative to isoprenaline (as 100) obtained. 2. Hexoprenaline clearly delineated between those tissues classified as containing beta2-adrenoreceptors (trachea, hind limb blood vessels and uterus; relative potencies 219, 110 and 76 respectively) and those classified as containing beta1-adrenoreceptors (atria and ileum; relative potencies 3.3 and 1.0 respectively). 3. Hexoprenaline differed from some previously studied noncatecholamine beta-adrenoreceptor agonists in being only two-fold less potent, relative to isoprenaline, as a vasodilator in perfused hind limb than as a tracheal relaxant.
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006594:Hexoprenaline / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009928:Organ Specificity; D010627:Phenethylamines / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D010627:Phenethylamines; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D006594:Hexoprenaline; D007545:Isoproterenol