title: Cytomegalovirus retinitis secondary to chronic viremia in phagocytic leukocytes.
abstract: We studied the relationship between the duration and intensity of cytomegalovirus viremia, cytomegalovirus complement fixing antibody, and cytomegalovirus retinitis in 61 renal transplant recipients. Five (8%) patients had chronic viremia which lasted more than six months. Two of the five developed typical cytomegalovirus retinitis and a severe fungal infection after intensive viremia of more than 11 months' duration. Retinitis did not develop in 22 patients with short-term viremia. Infectious cytomegalovirus was largely associated with polymorphonuclear leukocytes, but the virus was associated with monocytes during the immature granulocytic response accompanying one patient's terminal illness.
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001424:Bacterial Infections / Q000150:complications; D002908:Chronic Disease; D003168:Complement Fixation Tests; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D007962:Leukocytes; D009000:Monocytes; D009181:Mycoses / Q000150:complications; D010586:Phagocytes; D011183:Postoperative Complications; D012173:Retinitis / Q000209:etiology*
chemical_list: D000914:Antibodies, Viral