title: Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys.
abstract: Four of 5 howler monkeys (Alouatta caraya) experimentally infected with Herpesvirus saimiri (HVS) developed a rapidly fatal malignant lymphoma accompanied by peripheral T-cell lymphocytosis. HVS was isolated from fresh and tissue cultured blood and tissue lymphocytes and from cell cultures derived from nonlymphoid organs. Humoral antibodies against HVS-induced antigens were detected in the sera of the animals. The in vitro response of the peripheral blood lymphocytes to mitogenic stimulants was depressed following HVS infection.
mesh_terms: D000508:Alouatta; D000818:Animals; D000956:Antigens, Viral; D002462:Cell Membrane / Q000276:immunology; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D000882:Haplorhini; D006564:Herpesviridae / Q000302:isolation & purification; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology / Q000302:isolation & purification; D007109:Immunity; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008934:Mitogens / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D013045:Species Specificity; D013601:T-Lymphocytes / Q000382:microbiology; D014412:Tumor Virus Infections / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D008934:Mitogens