Histochemical and histoenzymatic changes in mouse liver in subacute benzene intoxication.
The investigations were performed on mice. They were divided into a control group and 4 experimental groups. The experimental animals were administered intraperitoneally benzene 6 X every 24 h. The animals were decapitated 30 min. 4, 12 and 24 h after the last benzene administration. During the experiment, dyeing for neutral lipids and glycogen was carried out, and the activity of NADH2-r.t., SDH, G-6-Pase, ATP-ase and ACP was estimated. A decrease of glycogen content in liver cells, deviations in the amount of neutral lipids, reversible decrease of mitochondrial enzymes activity, and intensification of the processes of intracellular catabolism were found.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001554:Benzene / Q000378:metabolism / Q000506:poisoning*; D001711:Biotransformation; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D051379:Mice; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D008112:Liver Glycogen; D013385:Succinate Dehydrogenase; D009246:NADH Tetrazolium Reductase; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase; D000251:Adenosine Triphosphatases; D001554:Benzene