[Dopaminergic Neurotransmission in Parkinson's syndrome (author's transl)].
More recent electrophysiological and biochemical data dealing with the functioning of the central dopaminergic synapse are reviewed in relationship to Parkinsonian symptomatology. Emphasis is put on the influence of feedback mechanisms involving pre and postsynaptic receptor sites, the dopaminergic-cholinergic imbalance and receptor supersentitivity. Stimulation of the dopamine-sensitive adenylatecyclase proved to be a good indicator of central dopaminergic receptor stimulation. Current therapeutic concepts are discussed in view of their limitations and side-effects.
D000262:Adenylyl Cyclases; D004298:Dopamine / Q000502:physiology*; D005246:Feedback; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology*; D013569:Synapses; D009435:Synaptic Transmission
D000262:Adenylyl Cyclases; D004298:Dopamine
Dopaminerge Neurotransmission beim Parkinson-Syndrom.