The use of early embryo aggregation derived mouse chimaeras. II. The study of disease processes.
Early embryo aggregation derived mouse chimeras have proven an extremely valuable tool to study development of disease processes. In this respect chimaeras prove a unique opportunity to study the interaction between cells genetically pre-destined to become diseased and a normal cell population within the same animal. In this situation chimaeras can be studied in view of possible 'correction' of the disease by the provision of a population of normal host cells and/or their products. Various host deficiency states including classic immune deficiency, potentially 'deficient' anemias and tumours have been studied--the subject of the review here.
D000375:Aging; D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics; D000748:Anemia, Macrocytic / Q000235:genetics; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002449:Cell Aggregation; D002678:Chimera; D004622:Embryo, Mammalian / Q000166:cytology*; D005260:Female; D030342:Genetic Diseases, Inborn; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics; D008223:Lymphoma / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D051379:Mice; D009030:Mosaicism; D009136:Muscular Dystrophies / Q000235:genetics; D010954:Plasmacytoma / Q000235:genetics; D011247:Pregnancy; D012162:Retinal Degeneration / Q000235:genetics; D012729:Sex Chromosome Aberrations