Induction of papillary ependymomas and insulinomas in the Syrian golden hamster by BK virus, a human papovavirus.
Newborn hamsters were inoculated intracerebrally with BK virus. Between 3 and 6 months after inoculation, they developed papillary ependymoma (8 hamsters, 42%) or functional malignant islet cell tumors of the pancreas (insulinoma, 8 hamsters), or both (1 hamster). Both tumors contained an antigen reactive to SV40 T-antibody, suggesting that at least a part of BK virus genomen has been integrated into the tumor cells. No infectious virus was detected in the extract of these tumors.
D007516:Adenoma, Islet Cell / Q000382:microbiology*; D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D001739:BK Virus / Q000472:pathogenicity*; D001786:Blood Glucose / Q000378:metabolism; D001932:Brain Neoplasms / Q000382:microbiology; D006224:Cricetinae; D004806:Ependymoma / Q000382:microbiology*; D005128:Eye Diseases / Q000382:microbiology; D005260:Female; D007328:Insulin / Q000097:blood; D011120:Polyomavirus / Q000472:pathogenicity*; D011247:Pregnancy; D013539:Simian virus 40 / Q000276:immunology
D000956:Antigens, Viral; D001786:Blood Glucose; D007328:Insulin