The role of oestrogen replacement in the climacteric syndrome.
Using a double-blind placebo-controlled cross-over design, the effect of equine conjugated oestrogens tablets (Premarin) was studied in 20 women with the climacteric syndrome followed during 15 months. Sixteen women were equally improved on placebo and oestrogen. Only 2 patients had an improved sense of well-being on oestrogen and not on placebo. The psychological diagnosis was unrelated to the subjective response to oestrogen or placebo. Performance in psychological tests administered before and during treatment periods was not changed by oestrogen or placebo.
D000328:Adult; D001291:Attitude of Health Personnel; D002979:Climacteric / Q000187:drug effects*; D003321:Cornell Medical Index; D003863:Depression / Q000188:drug therapy; D004311:Double-Blind Method; D004341:Drug Evaluation; D004644:Emotions / Q000187:drug effects; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010556:Personality Tests; D010919:Placebos; D011369:Professional-Patient Relations
D004966:Estrogens, Conjugated (USP); D010919:Placebos