Antiviral activity of certain hetarylhydrazones in Mengo virus infected mice.
Out of a series of eleven related hetarylhydrazones four derivatives (ZIMET 124/73, ZIMET 38/74, ZIMET 44/69, and IMET 98/69), after subcutaneous administration (0.5 mmole/kg per injection), were found to possess significant antiviral activity against rapidly progressing and highly lethal Mengo virus encephalitis in mice. After peroral administration (2 mmole/kg per injection) only with IMET 98/69 significant protection was achieved. Drug treatments were given twice daily for 5 days. The effectiveness of compounds was evidenced by significant "rates of protection". Possible relationships between the antiviral activity and the structure of compounds are discussed.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004671:Encephalitis, Arbovirus / Q000188:drug therapy; D006801:Humans; D006835:Hydrazones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008574:Mengovirus / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D006835:Hydrazones