Epstein-Barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.
When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited EBV-induced transformation and EBV superinfection of target cells. Unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenged with the antigens. This indicates that cell-mediated immunity and its associated soluble mediators may be involved in the control of EBV infection and that the interferon release assay is a useful in vitro correlate for the study of cellular immunity to EBV.
D000914:Antibodies, Viral; D000956:Antigens, Viral; D002464:Cell Migration Inhibition; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D009500:Neutralization Tests; D014373:Tuberculin / Q000494:pharmacology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D014373:Tuberculin