[Enzymatic activity of glucose-6-phosphate metabolism in the liver during the administration of a hepatic carcinogen].
In liver tissue of mice, administered with diethyl nitrosamine (2.5 mg/kg of body weight) within 2-8 months, activities of hexokinase and glucoso-6-phosphate dehydrogenase were increased and the activity of glucose-6-phosphatase was decreased . Termination of the administration of diethyl nitrosamine, which was carried out during 1-2 months, caused the temporary normalization of the enzymatic activity, but later on the alterations typical for carcinogensis were developed. After more prolonged administration of diethyl nitrosamine the period of normalization gradually disappeared. The distinct alterations in the enzymatic activity, after termination of diethyl-nitrosamine administration, were closely related to development of tumors in liver tissue.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D005941:Glucokinase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009602:Nitrosamines / Q000494:pharmacology*; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D005958:Glucosephosphates; D009602:Nitrosamines; D004052:Diethylnitrosamine; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D005941:Glucokinase; D005952:Glucose-6-Phosphatase
Aktivnost' fermentov obmena gliukozo-6-fosfata v pecheni pri vvedenii gepatokantserogena