title: [Biochemistry of collagen and locomotor apparatus. Hereditary diseases of the connective tissue and rheumatic diseases (3)].
abstract: In inflammatory granuloma, synovial sclerosis or inflammation and in Dupuytren's contracture, the neocollagen contains chains and/or transverse links that are characteristic of rapidly growing immature tissues. In arthrosis, a conversion of collagen synthesis towards a cutaneous type may occur. The destruction of cartilage in rheumatoid arthritis is brought about by a specific collagenase that originates from the inflamed synovial membrane. Finally, certain forms of osteoporosis may be due to alterations of the osseous collagen which impair the mechanism of calcification.
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D001847:Bone Diseases / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D003095:Collagen Diseases / Q000378:metabolism; D004387:Dupuytren Contracture / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006097:Granulation Tissue / Q000378:metabolism; D006099:Granuloma / Q000378:metabolism; D006801:Humans; D006901:Hydroxylysine / Q000032:analysis; D003012:Microbial Collagenase / Q000378:metabolism; D010001:Osteitis Deformans / Q000378:metabolism; D010003:Osteoarthritis / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D011487:Protein Conformation; D012216:Rheumatic Diseases / Q000378:metabolism*; D012598:Sclerosis; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000378:metabolism
chemical_list: D006901:Hydroxylysine; D003094:Collagen; D003012:Microbial Collagenase
vernacular_title: Biochimie du collagène et appareil locomoteur. Maladies héréditaires du tissu conjonctif et affections rhumatologiques (3e partie)