Corticosteroid response of rabbits and rats to exogenous ACTH.
The dynamics of the alterations of the cortisol: corticosterone ratio in rabbits during porcine ACTH administration were studied on an almost daily basis and as a function of time after injection. In rabbits the cortisol: corticosterone ratio increased strikingly but variably during the treatment period. Rats responded to similar treatment only with increased corticosterone release. The differences are attributed to the presence of 1-39 ACTH as well as intermediate ACTH in the rabbit pituitary but not in the rat pituitary.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D007700:Kinetics; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D006854:Hydrocortisone