Lithium-angiotensin interaction in rat neurohypophysis.
The effects of various concentrations of lithium upon basal and angiotensin-stimulated cyclic AMP accumulation were studied in isolated rat neurohypophysis. High doses of lithium diminished significantly the spontaneous accumulation of the nucleotide. This effect was not influenced by pre-incubation. Angiotensin-stimulated accumulation was inhibited by lithium at a dose which did not interfere with the basal accumulation of cyclic AMP. The possible physiological significance and mechanism of action are discussed.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000804:Angiotensin II; D008094:Lithium; D000242:Cyclic AMP