Neoplasia in the rat induced by N-hydroxyphenacetin, a metabolite of phenacetin.
N-hydroxyphenacetin, a phenacetin metabolite, was fed to rats as a 0.05-0.5% dietary supplement. After 9 months, tumours of the liver were found in 36 of 64 animals. One animal also developed a renal tumour. No tumours were found in control animals. The findings implicate phenacetin as a carcinogen and suggest that N-hydroxyphenacetin may be the metabolite responsible.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D010615:Phenacetin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D051381:Rats
D010615:Phenacetin