Immunologic "memory" for microbial antigens in lymphocytes obtained from human bronchial mucosa.
Memory for previous immunologic contact with microbial antigens has been detected in lymphocytes from human bronchi as a secondary immune response, when tested in vitro. Antigens stimulated a predominantly proliferative response in blood lymphocytes that was significantly greater than the response in mucosal lymphocytes with purified protein derivative and Herpes simplex type 1 antigens. Co-culture experiments with autologous blood lymphocytes showed that cell-dependent suppression was one mechanism of the low response of bronchial lymphocytes. In the patient who inhaled a foreign body, a proliferative response to antigens was restricted to bronchus-associated lymphoid tissue lymphocytes, suggesting a recruitment of antigen-reactive cells from a circulating pool.
D000956:Antigens, Viral; D001980:Bronchi / Q000276:immunology*; D001987:Bronchiectasis / Q000276:immunology; D002478:Cells, Cultured; D005547:Foreign Bodies; D006801:Humans; D007156:Immunologic Memory; D008175:Lung Neoplasms / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology; D008459:Measles virus / Q000276:immunology; D009092:Mucous Membrane / Q000276:immunology; D010224:Parainfluenza Virus 3, Human / Q000276:immunology; D012137:Respiratory System / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D014373:Tuberculin
D000956:Antigens, Viral; D014373:Tuberculin