Effect of human nasal secretions on the antiviral activity of human fibroblast and leukocyte interferon.
Many normal human nasal secretions contain an inhibitor of human fibroblast IF. This inhibitor had no effect on human leukocyte IF. The amount of inhibition of fibroblast IF increased with increasing quantities of nasal secretions. Also, the inhibition could be overcome with increasing concentrations of IF.
D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D007962:Leukocytes; D051379:Mice; D009093:Mucus / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism*; D014721:Vesicular stomatitis Indiana virus
D007372:Interferons