Properties of a transposon conferring resistance to penicillins and streptomycin.
R938 carries a transposon (TAbeta) of approximate molecular weight 9.5 Megadaltons (Mdal, 10(6) daltons). This contains genes for a beta lactamase of type TEM-1 and for streptomycin phosphatransferase (SPT). There is a ten-fold difference in the efficiency of transposition in different strains of E. coli K12.
D002876:Chromosomes, Bacterial; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000302:isolation & purification*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D010405:Penicillinase / Q000235:genetics; D010406:Penicillins / Q000494:pharmacology*; D010770:Phosphotransferases / Q000235:genetics; D011815:R Factors; D013307:Streptomycin / Q000494:pharmacology*
D004269:DNA, Bacterial; D010406:Penicillins; D010770:Phosphotransferases; D010405:Penicillinase; D013307:Streptomycin