Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
Regressor serum from MSV-M-infected mice markedly reduced MSV-M oncogenesis when administered i.p. (0-1 ml/mouse) as much as 30 days before i.m. MSV-M infection in adult BALB/c mice. The regressor serum activity appeared to be directly dependent on the amount of IgG, as shown by: (1) inactivity of sera which have low virus-neutralizing antibody content; (2) high effectiveness only of the IgG serum fraction; (3) inactivity of regressor serum incubated with anti-mouse gamma-globulin serum. The regressor serum activity was specific and could not be ascribed to interferon or interferon-inducing factors, antigen-antibody complexes or free antigen. The activity was not suppressed by sublethal irradiation (380 rad) of recipient mice. These results suggest that the activity of regressor serum administered before MSV-M infection is mediated through sensitization of host cells which are not radiosensitive.
D000818:Animals; D000912:Antibodies, Neoplasm; D000918:Antibody Specificity; D002460:Cell Line; D007106:Immune Sera; D007074:Immunoglobulin G; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009053:Sarcoma Viruses, Murine / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology*; D013997:Time Factors; D014185:Transplantation, Isogeneic
D000912:Antibodies, Neoplasm; D007106:Immune Sera; D007074:Immunoglobulin G