Specific immunity to human papilloma virus (HPV) in patients with genital warts.
A study of human papilloma virus (HPV) specific cellular and humoral immunity in 30 patients with genital warts is reported. By in vivo testing with purified, inactivated plantar wart virus, a cell-mediated immunity to HPV was determined in 60% of patients. Circulating antibodies, evaluated by immunofluorescence testing, were rare, but these increased after an intradermal test had been carried out, especially in patients with a positive skin test, suggesting a booster effect. No significant difference was found between this group of patients and those having skin warts. Our results showed a specific immune response to HPV in most patients, confirming the role of the viral agent in the induction of genital warts.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D005832:Genital Diseases, Male / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000276:immunology*; D014860:Warts / Q000276:immunology*
D000914:Antibodies, Viral