An autopsy case of cholangiocarcinoma with hypercalcemia.
Au autopsy case of cholangiocarcinoma which showed clinically hypercalcemia and hypophosphatemia without bone metastases is presented in this report. Although parathyroid hormone (PTH)-like substance of 520 ng/g. dry weight was measured in neoplastic tissue by the radioimmunoassay, membrane-limited secretory granules as those of parathyroid gland were not found in the fine structure. The significance of an existence of secretory granules in ectopic PTH producing tumor is discussed.
D002759:Adenoma, Bile Duct / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D001650:Bile Duct Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006729:Hormones, Ectopic / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D010281:Parathyroid Hormone / Q000378:metabolism
D006729:Hormones, Ectopic; D010281:Parathyroid Hormone