[Effect of cortisol on the state of adenyl cyclase system in rabbits].
Content of 3',5'-cycloAMP was estimated in rabbit blood plasma and urine; activities of adenylcyclase and phosphodiesterase were determined in liver tissue, adipose tissue and adrenal glands within 5, 24 and 48 hrs after hydrocortisone administration. Concentration of 3',5'-cycloAMP was found to be increased 4-6-fold in plasma and urine after the hormone administration. Cortisol was shown to increase also the activity of adenylcyclase and phosphodiesterase in liver tissue within 5 hrs and in adipose tissue--within 24 hrs and 48 hrs after the administration. In adrenal glands hydrocortisone caused an inhibitory effect on the adenylcyclase activity at early steps of the experiment.
D000249:Adenosine Monophosphate; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000273:Adipose Tissue / Q000201:enzymology; D000311:Adrenal Glands / Q000201:enzymology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004822:Epididymis / Q000201:enzymology; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D000249:Adenosine Monophosphate; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006854:Hydrocortisone
Vliianie kortizola na sostoianie adeniltsiklaznoĭ sistemy u krolikov