Integration of lipid utilization with Krebs cycle activity in muscle.
This essay illustrates the ways in which beta-oxidation and the citric acid cycle interact. These included: 1) competition for CoASH, 2) competition for NAD+, and 3) competition for FADH2 oxidation. By means of the above, the cell is able to maintain a precise coordination between the activation of fatty acids in the cytosol, beta-oxidation in the mitochondria, and the complete oxidation of acetyl-CoA to CO2 via the citric acid cycle throughout a wide range of energy demands and oxygen availability.
D000818:Animals; D002952:Citric Acid Cycle; D003065:Coenzyme A / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D005796:Genes; D000860:Hypoxia / Q000378:metabolism; D007313:Insecta / Q000378:metabolism; D050356:Lipid Metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D013045:Species Specificity; D014714:Vertebrates / Q000378:metabolism
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D009243:NAD; D005182:Flavin-Adenine Dinucleotide; D003065:Coenzyme A