Cell mediated immunity in experimental influenza and parainfluenza infection.
Cell mediated immunity (CMI) to Sendai and Kunz viruses, determined by a 51Cr release assay of cytotoxicity, has been shown to develop during the course of these infections. This virus specific response is mediated by sensitised T cells, and takes place against a background of innate cell mediated immunity. The mediator of this innate cytotoxicity exhibits none of the characteristics of T, B or K cells, but bears close resemblance to the NK cell which is spontaneously cytotoxic for certain tumour cells. Removal of the virus specific CMI by T cell depletion produces a moderate immunosuppressive effect. The nature of this effect and the role of CMI in these infections are discussed.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D009980:Influenza A virus / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology