title: Genes responsible for transformation by avian RNA tumor viruses.
abstract: Avian sarcoma viruses probably contain 4 genes. One of these, src, controls the process of transformation of the infected cell and has been located near the 3' end of the viral genome. The remaining 3 genes direct the synthesis of virion proteins: env (envelope proteins), pol (polymerase), and gag (internal proteins). They are probably in the order gag-poly-env-src. A scheme for the replication of these viruses is proposed, and several possible mechanisms for their origin and variability are discussed.
mesh_terms: D001355:Alpharetrovirus; D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D005796:Genes; D005815:Genetic Code; D009154:Mutation; D012367:RNA, Viral; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins