Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study.
Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titres to Epstein-Barr virus structural antigens are at high risk of developing Burkitt's lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances.
D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis; D002051:Burkitt Lymphoma / Q000209:etiology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003043:Cocarcinogenesis; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008288:Malaria / Q000150:complications; D008297:Male; D014454:Uganda
D000914:Antibodies, Viral