Leukocyte and lymphocyte cyclic AMP responses in atopic eczema.
Lymphocytes from subjects with mild and severe atopic eczema were compared with normal control subjects in regard to their cAMP (3';5'-cyclic adenosine monophosphate) responses to a variety of stimulatory agents. Individuals in the severe eczema group were shown to have a significant diminution in their unstimulated lymphocyte cAMP levels and absolute cAMP responses to 0.5 mM theophylline, 0.5 mM theophyline + 1 micronM epinephrine, 10 mM isoproternol, 1 mM isoproterenol, 10 mM salbutamol, and 3 micron M PGE1. Individuals with mild eczema had a reduced response to 0.5 mM theophylline. The severe eczema groups also differed in a number of these responses from a group of 5 subjects with severe psoriasis. Mixed leukocyte cAMP responses to 10 mM isoproterenol also were examined and found to be diminished in individuals with eczema.
D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004485:Eczema / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D011565:Psoriasis / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology
D011458:Prostaglandins E; D013806:Theophylline; D000242:Cyclic AMP; D007545:Isoproterenol; D000420:Albuterol; D004837:Epinephrine