Possible role of initiation factor activity in the action of interferon.
Treatment of mouse L cells with homologous interferon results in the production of a protein which inhibits initiation factor activity. Characterization experiments indicate that the interferon in the preparation is responsible for the induction of an inhibitor protein. The impairment of initiation factor activity induced by interferon is specifically reversed by cAMP. An inhibitor protein may be separated from the initiation factor activity by glycerol density gradient sedimentation. The molecular weight of the inhibitor is about 50,000 dalton and sediments with protein kinase activity.
D000242:Cyclic AMP / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D006358:Hot Temperature; D007372:Interferons / Q000494:pharmacology*; D008970:Molecular Weight; D010448:Peptide Initiation Factors / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D014764:Viral Proteins / Q000096:biosynthesis*
D010448:Peptide Initiation Factors; D014764:Viral Proteins; D003609:Dactinomycin; D007372:Interferons; D003513:Cycloheximide; D000242:Cyclic AMP