Adenyl cyclase.
Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The coupling between hormone receptors and this enzyme is discussed as is the ability of agents such as hormones, ATP, magnesium, calcium, guanine nucleotides and prostaglandins to alter cyclase activity. Several diseases that result from derangements of the adenyl cyclase system are known and the molecular bases for these diseases are discussed in this review.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism / Q000502:physiology; D002412:Cations; D000242:Cyclic AMP / Q000096:biosynthesis; D005459:Fluorides / Q000502:physiology; D006801:Humans; D009711:Nucleotides / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D011956:Receptors, Cell Surface
D002412:Cations; D009711:Nucleotides; D011453:Prostaglandins; D011956:Receptors, Cell Surface; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D005459:Fluorides