Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with oligodendrogliomas.
On the basis of a three stage grading system we report 23 stage one recurrent oligodendrogliomas (O 1), and 29 stage two recurrent oligodendrogliomas (O 2). In the O 1 group after the first interval 15 became O 2 and 2 became glioblastomas. Twenty tumours of the O 2 group after the first interval were not changed, three became oligodendroglioma-astrocytomas stage 2, and six became glioblastomas. The time relation for the recurrent phase in the primary O 1 group is calculated as 42 months, and in the primary O 2 group as 22 months, but this is without significance. For the development of malignancy, especially for the change to glioblastoma, a prominent participation by transformed local astrocytes seems to be essential. Postoperative irradiation most probably does not favour malignant change. A prolongation of the expectation of life by radiotherapy is not noticed.
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D002531:Cerebellum / Q000473:pathology; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000145:classification / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D009837:Oligodendroglioma / Q000145:classification / Q000473:pathology* / Q000601:surgery