Prostaglandins and sleep. Awaking effect of prostaglandins and sleep pattern of essential fatty acids deficient (EFAD) rats.
The experiments were carried out to investigate the effects of prostaglandins (PGs) on the sleep pattern in the cat, and in normal and EFAD rats. The data indicate that the duration of slow wave sleep (SWS) was significantly longer in EFAD rats compared with the normal rats. However, no difference in the REM sleep was observed between the two groups. Intraventricular (i.vc. )administration of PGE1, PGE2 and PGF2alpha increased wakefulness without a significant alteration of REM sleep. PGE1 administered i.vc. did not alter the duration of SWS or REM sleep in the chronic cat, but induced ponto-geniculo-occipital (PGO) waves (spikes) which are the phasic phenomenon of REM sleep. The fact that previous administration of 5-hydroxytryptophane abolished the PGE1-induced PGO spiking, might indicate that this drug triggered the spikes mainly via the functional inhibition of the serotonergic system.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D002415:Cats; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D005228:Fatty Acids, Essential; D011458:Prostaglandins E; D011460:Prostaglandins F; D006916:5-Hydroxytryptophan