Metabolic responses to the administration of angiotensin II, K and ACTH in two salt-wasting syndromes.
Metabolic responses to the administration of Angiotensin II, K and ACTH are described in two salt-wasting syndromes: hypoaldosteronism in Jews from Iran, which is characterized by an enzymic block in the conversion of 18-hydroxycorticosterone to aldosteron; and pseudohypoaldosteronism, a disorder in which aldosterone secretion is high in association with renal tubular unresponsiveness to mineralocorticoids. The response of plasma and urinary aldosterone to K and ACTH is qualitatively normal in hypoaldosteronism; however, infusion of Angiotensin II, in a dose that was pressor and elevated aldosterone levels threefold in control subjects, was only pressor in hypoaldosteronism. In pseudohypoaldosteronism, plasma and urinary aldosterone respond to Angiotensin II, K and ACTH, notwithstanding very high basal hormonal levels.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000450:Aldosterone / Q000097:blood / Q000172:deficiency; D000804:Angiotensin II / Q000627:therapeutic use*; D002675:Child, Preschool; D004032:Diet; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007223:Infant; D008297:Male; D008661:Metabolism, Inborn Errors / Q000097:blood / Q000188:drug therapy*; D011188:Potassium / Q000097:blood / Q000627:therapeutic use*; D012964:Sodium / Q000097:blood*; D014883:Water-Electrolyte Imbalance / Q000097:blood / Q000188:drug therapy*
D000804:Angiotensin II; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D011188:Potassium; D006854:Hydrocortisone