[Effects of several catecholamine-related drugs on aggressive behavior, brain noradrenaline content and tyramine uptake by isolated mice].
Such effects were studied in male albino mice maintained under isolation circumstances for 7 weeks in order to induce aggressiveness. L-DOPA (25 mg/kg) was given concomitantly with DDC (75 mg/kg) or reserpine (0.1 mg/kg), or each was administered signly and intraperitoneally to subjects twice weekly. Two peaks on the aggressive degree were observed at the 3rd-4th and 6th weeks, respectively. At the first peak, mice treated with L-DOPA and/or reserpine demonstrated aggressive behavior to a higher degree than control mice but at the second peak, to a lower degree. Mice treated with L-DOPA and DDC showed the highest degree at the second peak. Tyramine uptake in the brain measured at the 6th week was enhanced in mice treated with combinations of L-DOPA with reserpine or DDC. Noradrenaline content in the brain was lowered in mice treated with L-DOPA and/or reserpine, in comparison with each control value; It is thus concluded that catecholamine-related drugs influence the degree of enhancement of aggressiveness in modes which vary depending on the form of action of each drug.
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004050:Ditiocarb / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004336:Drug Antagonism; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000032:analysis*; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology*; D012934:Social Isolation; D013859:Thiocarbamates / Q000494:pharmacology*; D014439:Tyramine / Q000378:metabolism*
D013859:Thiocarbamates; D007980:Levodopa; D012110:Reserpine; D004050:Ditiocarb; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine