Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses.
Mouse strain G was studied for its susceptibility to various strains of murine leukemia and sarcoma viruses. Both N- and NB-tropic Friend leukemia viruses neither induced splenomegaly nor grew efficiently in strain G mice. Using the XC test, cultured embryo cells were found to be resistant, but not absolutely, to all the tested viruses, N-tropic AKR virus, N- and NB-tropic Friend leukemia viruses, NB-tropic Rauscher leukemia virus, B-tropic WN1802B virus, NB-tropic Moloney leukemia and sarcoma viruses, and N-tropic Kirsten sarcoma virus, although the resistance to Moloney leukemia and sarcoma viruses is sometimes not as strong as that for other viruses. Thus, the strain G mice are unique among mouse strains because they show resistance that is not related to the N-B tropism of murine leukemia viruses.
D000406:AKR murine leukemia virus / Q000254:growth & development; D000818:Animals; D046508:Culture Techniques; D005260:Female; D005622:Friend murine leukemia virus / Q000254:growth & development; D007109:Immunity; D009052:Leukemia Virus, Murine / Q000254:growth & development*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D008979:Moloney murine leukemia virus / Q000254:growth & development; D011925:Rauscher Virus / Q000254:growth & development; D009053:Sarcoma Viruses, Murine / Q000254:growth & development; D013045:Species Specificity; D013154:Spleen / Q000382:microbiology; D013163:Splenomegaly / Q000209:etiology; D014412:Tumor Virus Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology