Effect of dibutyryl cyclic AMP on neuromuscular transmission in myasthenia gravis.
The effect of dibutyryl 3',5'-cyclic monophosphate (D-cAMP) on the neuromuscular transmission was studied in a patient with myasthenia gravis during anesthesia. D-cAMP caused a slight increase in single twitch tension, and an initial transient decrease in tension which resulted from the trains of 2 Hz stimuli disappeared after D-cAMP. The finding of the present study suggests that D-cAMP has an anti-fatigue effect in patients with myasthenia gravis.
D000328:Adult; D003994:Bucladesine / Q000494:pharmacology*; D004558:Electric Stimulation; D005385:Fingers; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D009119:Muscle Contraction; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects
D003994:Bucladesine