[Possible participation of prostaglandins A1 and B1 in the development of internal carotid artery spasm].
Experiments were carried out on dogs with the internal carotid artery circulatory isolated and continuously perfused in situ with oxygenated Ringer-Krebs bicarbonate solution. Prostaglandins A1 and B1 (PG-A1 and PG-B1) exerted a constrictory effect on the artery. The effect of both prostaglandins was significantly less, but more prolonged than that of the same doses of serotonin. A possible role of PG-A1 and PG-B1 in the development of vasospasm is testified to by the following experimental results: a) during repeated action of PG-A1 AND PG-B1 their effect did not change, and therefore it should not decrease under prolonged influence of these prostaglandins on the vascular wall;) b) the mentioned prostaglandins caused potentiation of the constrictory effect of both serotonin and norepinephrine.
D000818:Animals; D002343:Carotid Artery, Internal / Q000187:drug effects*; D003250:Constriction; D004285:Dogs; D004357:Drug Synergism; D009638:Norepinephrine / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology
D011453:Prostaglandins; D011454:Prostaglandins A; D011942:Receptors, Adrenergic, alpha; D011985:Receptors, Serotonin; D012701:Serotonin; D009638:Norepinephrine
O vozmozhnom uchastii prostaglandinov A1 i B1 v voznikovenii spazma vnutrennikh sonnykh arteriĭ.