title: Interferon induction by radioprotective mercaptoalkylamines and derived thiophosphates.
abstract: Radioprotective thiols (five mercaptoalkylamines and four derived thiophosphates) induced interferon and resistance to virus infection. Interferon production occurred in human and mouse nonlymphoid cell cultures. One of the thiols, S,2-aminoethylisothiourea, given intraperitoneally, protected mice against two unrelated viruses--Semliki forest virus and Herpesvirus hominis type 1. Two structurally different radioprotective thiols--the disulfide cystamine and L-cysteine--were unable to induce the firus resistance state or interferon.
mesh_terms: D000818:Animals; D001102:Arbovirus Infections / Q000517:prevention & control; D002478:Cells, Cultured; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis; D008297:Male; D051379:Mice; D012672:Semliki forest virus / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D007369:Interferon Inducers; D013438:Sulfhydryl Compounds; D007372:Interferons