Tremor caused by sympathomimetics is mediated by beta2-adrenoreceptors.
Tremor caused by beta-adrenostimulating drugs is known to be mediated by beta-receptors in skeletal muscles. In this study it was shown that tremor caused by terbutaline could be blocked by propranolol, a drug with both beta1- and beta2-blocking properties, but not by metoprolol, a beta1-selective antagonist. It is concluded that tremor caused by sympathomimetics in man is mainly mediated by beta2-receptors.
D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007258:Informed Consent; D008790:Metoprolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013566:Sympathomimetics / Q000494:pharmacology*; D013726:Terbutaline / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014202:Tremor / Q000139:chemically induced*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D011433:Propranolol; D008790:Metoprolol; D013726:Terbutaline