Thrombin decreases platelet cyclic AMP in the absence of prostaglandin synthesis.
Cyclic AMP first decreased in wahed platelets after the addition of 0.1 IU thrombin/ml and then increased progressively. Platelets pre-incubated with acetylsalicylic acid showed only a decrease of cyclic AMP upon addition of thrombin. Furthermore, two patients  with defective prostaglandin synthesis had always reduced cyclic AMP whether their platelets were pre-incubated with acetylsalicylic acid or not. Thus, if prostaglandin synthesis is inhibited the level of cyclic AMP decreased and did not increase with time.
D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D000242:Cyclic AMP / Q000097:blood*; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis; D011458:Prostaglandins E / Q000096:biosynthesis; D013917:Thrombin / Q000494:pharmacology*
D011453:Prostaglandins; D011458:Prostaglandins E; D000242:Cyclic AMP; D013917:Thrombin; D001241:Aspirin