Pancytopenia induced by aminoglutethimide in the treatment of breast cancer.
Aminoglutethimide is an investigational agent of proven benefit in the treatment of metastatic breast carcinoma. We report herein a case of aminoglutethimide-induced pancytopenia complicated by bleeding and gram-negative septicemia. Severe pancytopenia is a rare but important side effect of this new drug and is rapidly reversible when the agent is withdrawn.
D000368:Aged; D000616:Aminoglutethimide / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D010198:Pancytopenia / Q000139:chemically induced*
D000616:Aminoglutethimide