Metabolic approaches to studies on diabetic microangiopathy.
The chief purposes of this report are (a) to focus attention on various metabolic and pathophysiologic parameters relating prostaglandins (PGs) and thromboxanes to the slow but inexorable progression of vascular and blood cell dysfunction in diabetes mellitus and (b) to suggest areas of investigation that may be of fundamental importance for expanded areas of diabetes research. The prime thrust of these investigations would be to correlate these metabolic and pathophysiologic parameters with the vasculopathy of diabetes mellitus.
D001792:Blood Platelets / Q000201:enzymology / Q000502:physiology; D003094:Collagen; D000242:Cyclic AMP / Q000097:blood / Q000494:pharmacology; D003925:Diabetic Angiopathies / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000097:blood / Q000188:drug therapy; D004347:Drug Interactions; D004912:Erythrocytes / Q000378:metabolism; D005964:Glucosyltransferases / Q000097:blood; D006801:Humans; D006880:Hydroxy Acids / Q000378:metabolism / Q000502:physiology; D007213:Indomethacin / Q000627:therapeutic use; D009638:Norepinephrine / Q000494:pharmacology; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D011714:Pyrans / Q000378:metabolism / Q000502:physiology
D006880:Hydroxy Acids; D011453:Prostaglandins; D011714:Pyrans; D003094:Collagen; D000242:Cyclic AMP; D005964:Glucosyltransferases; D009638:Norepinephrine; D007213:Indomethacin