Hyperchloremia and negative anion gap associated with polymyxin B administration.
A patient receiving polymyxin B sulfate intravenously for Gram-negative "anion gap". Both abnormalities resolved following discontinuation of the drug. In vitro investigation suggested that the electrolyte abnormalities resulted from the polycationic properties of polymyxin B.
D000368:Aged; D000838:Anions; D002712:Chlorides / Q000097:blood*; D006801:Humans; D008297:Male; D011112:Polymyxin B / Q000009:adverse effects*; D011113:Polymyxins / Q000009:adverse effects*
D000838:Anions; D002712:Chlorides; D011113:Polymyxins; D011112:Polymyxin B