Selective association of murine T lymphoblastoid cell surface alloantigens with Mycoplasma hyorhinis.
Mycoplasma hyorhinis, isolated by isopycnic centrifugation from supernatants of a persistently infected murine T lymphoblastoid cell line, demonstrated the presence of the Thy-1.1 differentiation alloantigen and H-2Kk histocompatibility antigens. The murine leukemia virus-related gp70 antigen also present on the surface of these lymphoblastoid cells was absent from mycoplasma preparations. Quantitative assessment of Thy-1.1 present in preparations of M. hyorhinis revealed a specific activity greater or equal to that of membrane preparations from lymphoblastoid cells, suggesting a marked accumulation of this T lymphoblastoid cells, suggesting a marked accumulation of this T lymphocyte antigen by membrane-associated mycoplasmas. The accumulation of the Thy-1.1 antigen in association with purified mycoplasmas was also demonstrated in lymphoblastoid cells experimentally infected with a defined culture of M. hyorhinis.
D000954:Antigens, Surface; D000956:Antigens, Viral; D002460:Cell Line; D006023:Glycoproteins / Q000276:immunology; D006183:H-2 Antigens; D007519:Isoantigens; D009052:Leukemia Virus, Murine / Q000276:immunology; D009174:Mycoplasma / Q000276:immunology; D009175:Mycoplasma Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D000956:Antigens, Viral; D006023:Glycoproteins; D006183:H-2 Antigens; D007519:Isoantigens