Epstein-Barr virus and human malignancy.
The association of the Epstein-Barr virus and two human malignancies, Burkitt's lumphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. With our current state of knowledge we cannot conclude that the Ipstein-Barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its association with Burkitt's lymphoma and nasopharyngeal carcinoma.
D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002051:Burkitt Lymphoma / Q000276:immunology / Q000382:microbiology*; D002471:Cell Transformation, Neoplastic; D003043:Cocarcinogenesis; D004279:DNA, Viral / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000302:isolation & purification* / Q000648:ultrastructure; D006801:Humans; D007244:Infectious Mononucleosis / Q000382:microbiology; D008214:Lymphocytes / Q000382:microbiology; D008566:Membranes / Q000276:immunology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000382:microbiology*; D012328:RNA Viruses; D012882:Skin Tests
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral