10-years experience with a 28,800 roller bottle plant for FMD vaccine production.
The roller bottle plant at the Istituto Zooprofilattico of Brescia is described and the following topics are discussed: (1) results of ten years cell and virus culture; (2) critical approach to advantages and disadvantages of applied technology, and (3) FMD vaccine requirements and cell substrate characterization.
D005537:Aphthovirus / Q000254:growth & development*; D002478:Cells, Cultured; D004345:Drug Industry; D007558:Italy; D014765:Viral Vaccines; D014776:Virus Cultivation / Q000379:methods*
D014765:Viral Vaccines