Effect of paraquat on rat lung prolyl hydroxylase.
Acute administration of Paraquat (25 mg/kg, I.P.) was found to significantly increase prolyl hydroxylase in rat lung 7 days following treatment. There was no change in total collagen at this time point. At 21 days following drug treatment, total collagen was significantly elevated while prolyl hydroxylase activity had returned to control level.
D000818:Animals; D003094:Collagen / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010269:Paraquat / Q000009:adverse effects / Q000494:pharmacology*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D051381:Rats; D013997:Time Factors
D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D010269:Paraquat