Depression of REM sleep in cats by nisoxetine, a potential antidepressant drug.
Nisoxetine, a potent and specific inhibitor of norepinephrine uptake, suppressed REM sleep in cats. Oral doses as small as 0.1 mg/kg were effective during the first 2 1/2 hours of a recording session; 0.25 mg/kg, for 5 hours. The amount of slow wave sleep increased in cats that received 0.1-1.0 mg/kg of nisoxetine. These changes in sleep pattern resemble those reported after treatment with somewhat higher doses of tricylic antidepressants.
D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D004347:Drug Interactions; D005473:Fluoxetine / Q000031:analogs & derivatives; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D009661:Nortriptyline / Q000494:pharmacology; D010647:Phenyl Ethers / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D012895:Sleep, REM / Q000187:drug effects*; D013997:Time Factors
D010647:Phenyl Ethers; D011437:Propylamines; D005473:Fluoxetine; C011386:nisoxetine; D012701:Serotonin; D007980:Levodopa; D009661:Nortriptyline