Aspartate carbamoyltransferase inhibition and uridylate trapping result in a synergistic depression of uridine triphosphate in hepatoma cells.
D000818:Animals; D001221:Aspartate Carbamoyltransferase / Q000037:antagonists & inhibitors*; D001224:Aspartic Acid / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D005688:Galactosamine / Q000494:pharmacology; D007700:Kinetics; D008113:Liver Neoplasms / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000378:metabolism; D063065:Organophosphonates / Q000494:pharmacology; D051381:Rats; D014500:Uracil Nucleotides / Q000378:metabolism*
D063065:Organophosphonates; D014500:Uracil Nucleotides; D001224:Aspartic Acid; D005688:Galactosamine; D001221:Aspartate Carbamoyltransferase