Comparative effects of folate antagonists versus enzymatic folate depletion on folate and thymidine enzymes in cultured mammalian cells.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism; D002268:Carboxypeptidases / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005492:Folic Acid / Q000378:metabolism*; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007951:Leukemia, Myeloid / Q000201:enzymology* / Q000378:metabolism; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000378:metabolism; D010088:Oxidoreductases; D010770:Phosphotransferases / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013763:Tetrahydrofolates; D013937:Thymidine Kinase / Q000378:metabolism; D013938:Thymidine Monophosphate; D013940:Thymidylate Synthase / Q000378:metabolism
D005493:Folic Acid Antagonists; D013763:Tetrahydrofolates; D013938:Thymidine Monophosphate; D005492:Folic Acid; D010088:Oxidoreductases; D013762:Tetrahydrofolate Dehydrogenase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D013940:Thymidylate Synthase; D012696:Glycine Hydroxymethyltransferase; D010770:Phosphotransferases; D013937:Thymidine Kinase; D002268:Carboxypeptidases; D005574:Formate-Tetrahydrofolate Ligase