[The vehaviour of monoaminooxydase (MAO) activity in tumours. I. MAO activity measurement in experimental tumours (author's transl)].
The activity of MAO (EC 1.4.3.4) was measured in liver homogenates of mice with experimental tumours Sarcoma S-180 and Leukemia L-1210. The enzyme activity was determined by two methods: spectrophotometric--with benzylamine as a substrate and the second with the application of oxygen electrode and adrenaline as a substrate. An increase of the enzyme activity was observed in liver homogenates of mice with Sarcoma S-180 as compared with the controls. High activity of MAO with both substrates was also observed in Sarcoma ascites. In Leukemia L-1210 changes of activity in relation to adrenaline as a substrate were very small, but towards benzylamine the affinity of enzyme was higher (the increase of activity was about 50%).
D000818:Animals; D001201:Ascites / Q000201:enzymology; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms; D051379:Mice; D008811:Mice, Inbred DBA; D008995:Monoamine Oxidase / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000201:enzymology*; D012510:Sarcoma 180 / Q000201:enzymology
D008995:Monoamine Oxidase
Das Verhalten der Aktivität der Monoaminooxydase (MAO) bei Turmoren. I. Aktivitätsmessurg der MAO in experimentellen Aszitestumoren (Leukämie L-1210 und Sarkom S-180) bei Mäusen, unter Verwendung zweier verschiedener Methoden und Substrate