Inhibition of simian virus 40 DNA synthesis in Yaba virus-preinfected cells.
The effect of Yaba virus preinfection on DNA synthesis in SV40-infected Jinet cells was studied. Time-course synthesis studies were conducted using the incorporation of labeled thymidine. Yaba virus preinfection resulted in the inhibition of SV40 DNA synthesis when the elapsed time between Yaba virus and SV40 infections was three days. This inhibition was demonstrated by hybridization studies and sedimentation analysis. In addition, the usual stimulation of cellular DNA synthesis induced by SV40 infection was inhibited. This inhibition occurred at a time in Yaba virus infection when no cytoplasmic Yaba virus-specific DNA synthesis occurred.
D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D013539:Simian virus 40 / Q000378:metabolism*; D014779:Virus Replication; D014999:Yaba monkey tumor virus / Q000502:physiology*
D004279:DNA, Viral