Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer.
To test whether the distribution of AHH inducibility is shifted toward the high end of the range in patients who had lung and laryngeal cancer, we measured this trait in 59 patients (32 lung and 27 laryngeal) who had resectable tumors and had been disease-free for a period of time. The advantage of selecting patients who were free of clinical disease was that measurement of their AHH inducibility should not have been affected by the disease state. Patient and control populations showed no difference in basal and induced AHH activity of AHH inducibility. The mean AHH inducibility in patients who had lung cancer was 3.20 +/- 0.20; in patients who had laryngeal cancer 2.96 +/- 0.18, and for all controls 3.29 +/- 0.04 (no significant difference at p = 0 05). Further analysis of the distribution of AHH inducibility in the patient group compared to controls showed no suggestion of a shift toward the higher end of the range in patients who had lung and laryngeal cancer.
D000230:Adenocarcinoma / Q000201:enzymology; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000201:enzymology; D000328:Adult; D000367:Age Factors; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism*; D002277:Carcinoma / Q000201:enzymology*; D002278:Carcinoma in Situ / Q000201:enzymology; D018288:Carcinoma, Small Cell / Q000201:enzymology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology; D004790:Enzyme Induction; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012907:Smoking
D001189:Aryl Hydrocarbon Hydroxylases