Focal nodular hyperplasia of the liver associated with high-dosage estrogens.
A patient developed benign nodular hyperplasia of the liver after long-term, high-dose estrogen therapy. A 10.5-cm benign liver nodule appeared after three years of high-dose estrogen therapy and was resected. Fourteen months later, while still receiving estrogen, a 4.5-cm nodule and multiple small nodules were seen on angiography. Four months after estrogen was discontinued, the larger liver nodule disappeared and the smaller ones decreased.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced*; D008134:Long-Term Care; D011859:Radiography
D004966:Estrogens, Conjugated (USP)