The portals of entry of herpes simplex virus infections.
In the present paper different possible portals of entry into the body for Herpes simplex Virus are examined. The possibility to infect the cornea with HsV without a preceding scarification was established. Scanning microscopy clearly showed the lesions of the infected cornea and a parallelity between the concentration of the inoculum and the spread of lesions. The i.c., i.m. and i.p. portals of entry are compared as to their capacity to produce encephalitis. The titration of virus may also be realized in the animal experiment. The intragastric portal of entry could be clearly demonstrated. So it is possible to explain herpes encephalitis in human newborns from mothers infected with Herpes virus.
D000818:Animals; D001921:Brain / Q000473:pathology; D003315:Cornea / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000473:pathology / Q000635:transmission*; D006561:Herpes Simplex / Q000473:pathology / Q000635:transmission*; D007635:Keratitis, Dendritic / Q000473:pathology / Q000635:transmission*; D051379:Mice; D011817:Rabbits; D018139:Simplexvirus / Q000254:growth & development*; D013270:Stomach / Q000382:microbiology