Control of the interaction of cholesterol ester-rich lipoproteins with arterial receptors.
Incorporation of 125I-labeled cholesterol ester rich lipoproteins from cholesterol fed rabbits into normal rabbit aorta in vitro was inhibited by heparin, lecithin, and collagenase and by succinylation of the lipoprotein. Aortic uptake of lipoprotein was increased by neuraminidase, proteases, lipase, and beta-glucuronidase. These results suggest that it may be possible to control atherogenesis by controlling the interaction of atherogenic lipoproteins with their arterial receptor.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D001161:Arteriosclerosis / Q000188:drug therapy; D006493:Heparin / Q000494:pharmacology; D008074:Lipoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism; D011817:Rabbits; D011955:Receptors, Drug / Q000378:metabolism*
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D011955:Receptors, Drug; D006493:Heparin