No demonstrable accumulation of 14C-vitamin D3 in developing rat teeth and bones.
The distribution of 14C-vitamin D3 administered subcutaneously in arachidic oil to 6-day-old suckling rats has been examined autoradiographically. The animals were sacrificed 1, 2, 4 and 8 days after injection. The autoradiographic exposure time was 4 months. The sectioning and exposure was performed in a freeze-room. Radioactivity was found mainly in the liver, kidney, intestines and fat depots. No uptake was found in developing teeth or bones.
D000818:Animals; D001345:Autoradiography; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002762:Cholecalciferol / Q000008:administration & dosage / Q000378:metabolism*; D007279:Injections, Subcutaneous; D051381:Rats; D014070:Tooth / Q000254:growth & development / Q000378:metabolism*
D002250:Carbon Radioisotopes; D002762:Cholecalciferol