[Lessons drawn from granulocyte transfusions in the treatment of infections complicating aplasia induced by anti-leukemic chemotherapy].
The authors report the results of leukocyte transfusions of white cells obtained by sedimentation from donors with chronic myeloid leukemia, and by a continuous output cell separator used in healthy donors. The percentage of therapeutic efficacy of these two techniques is respectively, 62 and 78%. Among the factors affecting transfusion efficacy, the dose of injected leukocytes, the immunological compatibility and the functional value of the injected cells, appear of major importance. A qualitative study of the polymorphs in chronic myeloid leukemia, assessed by reduction with tetrazolium nitro-blue (N.B.T.) after ingestion of latex particles, proved normal when studied in vivo in the recipient. The mode of action of transfused leukocytes is then discussed.
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D001424:Bacterial Infections / Q000209:etiology / Q000628:therapy*; D001782:Blood Donors; D001803:Blood Transfusion; D002648:Child; D006098:Granulocytes; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D007951:Leukemia, Myeloid / Q000097:blood; D007962:Leukocytes; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy
Enseignements tirés des transfusions de granulocytes appliquées au traitement des infections compliquant les aplasies induites par les chimiothérapies anti-leucémiques