title: Drug and immuno-diagnostic resistant amoebic liver abscess in Ibadan: an elucidation of a possible mechanism.
abstract: A thick fibrous walling of amoebic abscess of the liver is very rare. Using as a basis the case of drug and immunodiagnostic resistant amoebic liver abscess in an adult Nigerian, an account is given of the possible mechanisms for such therapeutic and diagnostic failure. A theory of blood-abscess cavity barrier is postulated and suggested as a mechanism for the constant failure to detect antibodies to E. histolytica in the small percentage of cases of amoebic liver abscess (Morris, Powell and Elsdon-Dew, 1970). A study of the rate of diffusion of amoebic excretion/secretion through a thick fibrous tissue or artificial membrane of comparable properties is strongly advocated.
mesh_terms: D000328:Adult; D000563:Amebicides / Q000627:therapeutic use; D000906:Antibodies / Q000032:analysis*; D004352:Drug Resistance, Microbial; D004748:Entamoeba histolytica / Q000276:immunology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008101:Liver Abscess, Amebic / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008297:Male; D009549:Nigeria; D012698:Serologic Tests
chemical_list: D000563:Amebicides; D000906:Antibodies