Temperature-sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukaemogenesis.
A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degrees C. This indicates that the continuous expression of a viral gene product is necessary to maintain the undifferentiated state of the virus-transformed leukaemia cells.
D001355:Alpharetrovirus / Q000235:genetics / Q000472:pathogenicity*; D000818:Animals; D001354:Avian Leukosis Virus / Q000472:pathogenicity*; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002472:Cell Transformation, Viral; D004920:Erythropoiesis; D006454:Hemoglobins / Q000096:biosynthesis; D007942:Leukemia, Experimental / Q000382:microbiology*; D009154:Mutation; D013696:Temperature
D006454:Hemoglobins