[Immunogenicity and thymus-dependence of the polymerized alpha-toxoid of Clostridium perfringens].
Polymeric alpha-toxoid with a molecular weight of 450 000--600 000 was obtained by condensation of alpha-toxoid of Cl. perfringens, type A, with glutaric aldehyde. Experiments on guinea pigs showed that in the adsorbed preparations the immunogenic properties of both monomeric and polymeric alpha-toxoids are practically identical. The primary immune response after the immunization with nonadsorbed antigens was 3 times greater than that induced by the monomer. Polymerization of alpha-toxoid failed to change its thymus dependency.
D000818:Animals; D003016:Clostridium perfringens / Q000276:immunology*; D005738:Gas Gangrene / Q000276:immunology / Q000517:prevention & control*; D006168:Guinea Pigs; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011108:Polymers; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*; D014121:Toxoids
D011108:Polymers; D014121:Toxoids
Immunogennost' i timuszavisimost' polimerizovannogo alpha-anatoksina Clostridium perfringens.