The effect of temperature on the synthesis of rhinovirus type 2 RNA.
The reduced yields of rhinovirus type 2 at temperatures above 37 degrees C were shown to result from the degradation of virus-induced RNA, leaving little RNA available for inclusion into mature infectious virions. The degradation occurred about 6 h p.i., and appeared to be selectively effecting the single-stranded species. Lysosomal nucleases do not appear to have a role in this supra-optimal degradation.
D012367:RNA, Viral / Q000096:biosynthesis*; D012229:Rhinovirus / Q000254:growth & development / Q000378:metabolism*; D013696:Temperature; D014771:Virion / Q000254:growth & development / Q000378:metabolism
D012367:RNA, Viral