Adrenergic supersensitivity of the pupil in idiopathic headache.
In idiopathic headache (IH) sufferers, phenylephrine and fenfluramine induce a pupillary dilatation respectively greater and lesser than in controls. The difference may be due to a supersensitivity of the iris alpha adrenoceptors caused by a deficiency of noradrenaline in the iris adrenergic nerve terminal of the IH sufferer. These findings seem to support the hypothesis of a brain receptorial, monoamine supersensitivity in IH.
D000328:Adult; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology; D006261:Headache / Q000209:etiology*; D006801:Humans; D006967:Hypersensitivity; D007498:Iris / Q000294:innervation*; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D005277:Fenfluramine