Protective effect of polymyxin B sulfate in experimental meningococcal infection in mice.
The mouse model of intraperitoneal meningococcal sepsis was used to evaluate the antiendotoxic activity of polymyxin B sulfate independent of its antibiotic effects. Administered either before or after the infective challenge therapeutic doses of polymyxin B sulfate produced small but significant increases in survival over unprotected animals. These results also suggest that endotoxin contributes to the outcome in this variety of Gram-negative infection.
D000818:Animals; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors*; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D008589:Meningococcal Infections / Q000188:drug therapy*; D051379:Mice; D009345:Neisseria meningitidis; D011112:Polymyxin B / Q000494:pharmacology / Q000627:therapeutic use*; D011113:Polymyxins / Q000627:therapeutic use*
D001427:Bacterial Toxins; D004731:Endotoxins; D011113:Polymyxins; D011112:Polymyxin B