[Glucocorticoid receptors in mammary tumors in PS and C3H mouse strains (author's transl)].
Specific binding of glucocorticoids was characterized in mammary tumors and cells derived from C3H and PS mice. The binding protein satisfied all the general criteria of hormone receptors namely high affinity and binding specificity for glucocorticoids (KD congruent to 2.5 nM) for 3H Dexamethasone and limited number of binding sites (congruent to 150 femtomoles/mg Protein). The hormonal regulation of these receptors will be reported. The production of viral particles of type A and B was increased by glucocorticoids in the PS MT1 and PS MT2 cell lines derived from the PS tumors.
D000818:Animals; D002460:Cell Line; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D009363:Neoplasm Proteins / Q000378:metabolism; D011485:Protein Binding; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
D009363:Neoplasm Proteins; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003907:Dexamethasone
Récepteurs des hormones glucocorticoïdes dans les tumeurs mammaires de 2 lignées de souris PS et et C3H.