Development of early nuclear antigen in cytomegalovirus infected cells in the presence of RNA and protein synthesis inhibitors.
Human cytomegaloviruses (HCMV) induce nuclear antigens as early as I h after infection as detected by immunofluorescence. Early antigen development occurs in the presence of DNA, RNA, and protein synthesis inhibitors and is dependent on intact viral DNA in the inoculum.
D000956:Antigens, Viral; D002467:Cell Nucleus / Q000276:immunology*; D046508:Culture Techniques; D003513:Cycloheximide / Q000494:pharmacology*; D003561:Cytarabine / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000254:growth & development / Q000276:immunology*; D003609:Dactinomycin / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D011691:Puromycin / Q000494:pharmacology*
D000956:Antigens, Viral; D003561:Cytarabine; D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide