[Primary carcinoma of the liver and long-term administration of oral contraceptives followed by pregnancy (author's transl)].
A 32-year-old woman who had taken oral contraceptives for seven years, became pregnant after omitting the drug and had a normal child. Soon after a malignant hepatic tumour became apparent of which she died after three months. The tumour was a hepatocellular carcinoma, of low differentiation under the electron microscope. The tumour cells contained fibrils similar to alcoholic hyaline. A review of published reports suggests the possibility that the oral contraceptives and the hormonal influence of the pregnancy together played an important role in the development of the malignant tumour.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008134:Long-Term Care; D008854:Microscopy, Electron; D011247:Pregnancy
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined
Primäres Leberkarzinom nach mehrjáhriger Anwendung eines oralen Kontrazeptivums und Schwangerschaft.