title: Theophylline stimulation of binding of radioiodinated rat prolactin to murine mammary gland.
abstract: Characteristics of prolactin receptors of murine mammary glands were studied. Mammary gland exhibited low but specific binding to 125I-rPRL (rat prolactin). Receptors were heat susceptible and partly protein in nature. Theophylline--both in vitro and in vivo treatment--enhanced the binding of 125I-rPRL to receptors. It remains to be established whether this action of theophylline is mediated through cyclic AMP "Sparing" effect or through its direct effect on cell membrane stabilization.
mesh_terms: D000818:Animals; D005260:Female; D007457:Iodine Radioisotopes; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology*; D014106:Tosylarginine Methyl Ester / Q000494:pharmacology
chemical_list: D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D011388:Prolactin; D014106:Tosylarginine Methyl Ester; D013806:Theophylline