title: Cyclic GMP regulation and responses of Polysphondylium violaceum to chemoattractants.
abstract: In cells of the cellular slime mold Polysphondylium violaceum an attractant, which is released during the aggregation stage, causes a transient rise of the cyclic GMP concentration. Cells of this organism develop in shaken suspensions after they have finished growth. Cell development is not accompanied by an increase in the EDTA stability of cell adhesion. Both the developmental regulation and the specificity of chemotactic responses is reflected in the light scattering patterns recorded in cell suspensions: Folic acid causes a strong response in early preaggregation cells and the Polysphondylium attractant does the same in aggregation competent cells, whereas cyclic AMP is inactive in both stages.
mesh_terms: D002449:Cell Aggregation / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D000242:Cyclic AMP / Q000096:biosynthesis / Q000494:pharmacology; D006152:Cyclic GMP / Q000096:biosynthesis*; D004492:Edetic Acid / Q000494:pharmacology; D005492:Folic Acid / Q000494:pharmacology; D008027:Light; D009235:Myxomycetes / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D012542:Scattering, Radiation
chemical_list: D005492:Folic Acid; D004492:Edetic Acid; D000242:Cyclic AMP; D006152:Cyclic GMP