[Functional interrelations between isozymes of dehydrogenases in the intact and denervated rabbit muscles].
A correlation is shown to exist between malate dehydrogenase (MDH), lactate dehydrogenase (LDH) and glycerol-3-phosphate dehydrogenase (glycerol-3-PDH activity values, lactate/pyruvate and malate/oxaloacetate coefficients, MDH and LDH isozyme spectra and kinetic properties of LDH isozymes in soluble fractions of cytoplasm from intact rabbit m. soleus (red), m. gastrocnemius (mixed) and m. quadratus lumborum (white). In denervated soleus and gastrocnemius the cytoplasmic MDH/LDH, mitochondrial MDH/LDH, MDH mitochondrial/MDH cytoplasmic activity ratios, concentrations of substrates and isozyme spectra of MDH and LDH tend to equalize. The obtained results indicate the importance of isozyme composition and total activity ratios of the dehydrogenases for regulation of pyruvate and NADH metabolic pathways.
D000818:Animals; D003593:Cytoplasm / Q000201:enzymology; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D009121:Muscle Denervation; D009132:Muscles / Q000033:anatomy & histology / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D011817:Rabbits
D007527:Isoenzymes; D011773:Pyruvates; D009243:NAD; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase
Funktsional'nye vzaimootnosheniia izofermentov degidrogenaz v intaktnykh i denervirovannykh myshtsakh krolika