myo-Inositol metabolism in the neonatal and developing rat fed a myo-inositol-free diet.
Neonatal rats of the Holtzman strain, 6 days of age, were fed a myo-inositol restricted liquid formula by gastric intubation for 10 days, after which they were fed a purified myo-inositol-free diet until they were 72 days old. No differences in weight gain were observed between myo-inositol/100 ml of formula or 150 mg myo-inositol/100 g diet. Most tissues examined from rats fed the myo-inositol deprived formula and diet had lower free myo-inositol levels than the controls with the exception of the liver. Despite reduced free and lipid-bound myo-inositol in the liver, there was no evidence of fatty liver in the young rats at any age. The cerebrum and cerebellum of myo-inositol deprived rats had normal myelination and mitochondriogenesis as judged by the levels of 2',3'-cyclic nucleotide-3'-phosphohydrolase (EC 3.1.4.1) and fumarase (EC 4.2.1.2) activity, respectively.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D005260:Female; D005649:Fumarate Hydratase / Q000378:metabolism; D007294:Inositol / Q000378:metabolism / Q000627:therapeutic use; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000378:metabolism; D014804:Vitamin B Deficiency / Q000188:drug therapy / Q000378:metabolism*
D007294:Inositol; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D005649:Fumarate Hydratase