Further investigations on the antioncogenic activity of A/PR8/34 (HON1)- influenza virus on polyoma virus induced tumors in newborn Wistar rats.
The oncogenic activity of polyoma virus in newborn Wistar rats can be significantly reduced by simultaneous vaccination with the A/PR8/34 (HON1) strain of influenza virus. The antioncogenic activity (AOA) of influenza virus suspensions was neutralized by the addition of homologous influenza antibodies, indicating that AOA was due to influenza virus and not to any non-viral material possibly present. The AOA of influenza virus was found to decline with storage at 4 degrees C and to depend critically on the relative doses of influenza virus and polyoma virus inoculated per animal. Simultaneous inoculation of animals with influenza and polyoma virus reduced significantly the antibody response to polyoma virus in all experiments, suggesting that influenza virus reduced the multiplication of polyoma virus. By contrast, the antibody response to influenza virus was significantly enhanced by inoculation with polyoma virus in some experiments, only. Influenza virus was found to reduce markedly the adsorption of polyoma virus on rat embryo fibroblast cells, suggesting that AOA could be at least partially due to interference of influenza virus with polyoma virus adsorption on target cells.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D009500:Neutralization Tests; D011120:Polyomavirus / Q000276:immunology; D051381:Rats; D014412:Tumor Virus Infections / Q000276:immunology / Q000517:prevention & control*
D000914:Antibodies, Viral; D000970:Antineoplastic Agents; D007252:Influenza Vaccines