Inducing of automatism of Purkinje fibers with dibutyryl 3', 5' cyclic AMP.
Dibutyryl 3', 5'-cyclic AMP induced automatic activity in Purkinje fibers of myocardial strip in the rat. The phenomenon was not affected by beta adrenergic blockade.
D000818:Animals; D001332:Automatism / Q000187:drug effects; D003994:Bucladesine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011690:Purkinje Fibers / Q000187:drug effects*; D051381:Rats
D003994:Bucladesine; D011433:Propranolol; D009638:Norepinephrine