[Antiviral action of carminomycin and some of its derivatives].
Carminomycin was shown to inhibit the development of both the DNA-containing variolovaccine virus and the RNA-containing grippe virus in chick embryos. Comparison of the effects of rubomycin, carminomycin, 14-oxy-carminomycin and carminomycin complex with bovine serum albumin in experiments with chick embryos showed that the inhibitory effect of carminomycin and its derivatives on the development of the grippe virus was much higher than that of rubomycin. The carminomycin derivatives proved to be much more active in this respect than the initial antibiotic. Carminomycin and its derivatives had a therapeutic effect on mice with experimental grippe pneumonia also on their oral use.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000998:Antiviral Agents; D002360:Carubicin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002417:Cattle; D002642:Chick Embryo; D003630:Daunorubicin / Q000494:pharmacology; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D012710:Serum Albumin, Bovine / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D012901:Variola virus / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D004338:Drug Combinations; D012710:Serum Albumin, Bovine; D002360:Carubicin; D003630:Daunorubicin
Protivovirusnoe deĭstvie karminomitsina i nekotorykh ego proizvodnykh.