title: Prolactin content of the pituitary gland in response to hypertonic saline medium, antithyroid drugs, methallibure and thyroxine in a freshwater teleost Heteropneustes fossilis.
abstract: Variations in the prolactin content of the pituitary gland in response to different treatments were studied in a freshwater catfish, H. fossilis. One week of saline (1% NaCl medium) treatment reduced the pituitary prolactin content but enhanced the serum prolactin level showing release of prolactin from the pituitary gland. Two weeks of saline treatment reduced pituitary as well as serum prolactin content presumably a result of reduced prolactin synthesis in the pituitary gland. This reduction of synthetic activity in this species is probably due to a drop in prolactin requirement. All the antithyroid durgs tested as well as L-thyroxine decreased the pituitary prolactin content. Methallibure administration induced the release of prolactin from the pituitary as evidenced by the lowered prolactin level in this gland and a simultaneous increase in the prolactin content of the serum.
mesh_terms: D000818:Animals; D005260:Female; D005399:Fishes; D005618:Fresh Water; D008297:Male; D008693:Methallibure / Q000494:pharmacology*; D009994:Osmolar Concentration; D010472:Perchlorates / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013861:Thiocyanates / Q000494:pharmacology; D013889:Thiouracil / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D010472:Perchlorates; D012462:Saline Solution, Hypertonic; D013861:Thiocyanates; D012965:Sodium Chloride; D013889:Thiouracil; D011388:Prolactin; D013890:Thiourea; D008693:Methallibure; D013974:Thyroxine