The effect of ACTH on oxygen uptake by skeletal muscle, brain, liver, kidney and myocardium slices of the rat.
Using Wartburg's method the effect of ACTH on oxygen uptake by slices of various tissues of the rat was investigated in relation to the duration of ACTH action in the organism. A reduction in oxygen uptake by tissue slices was found 1 hour after ACTH injection with a rise after 16 hours. It seems that in the first phase ACTH exerts an inhibitory effect on tissue respiration indirectly through the adrenal cortex, while in the second phase it may exert a stimulatory influence either directly or by some other mechanisms.
D000302:Adrenal Cortex / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D000324:Adrenocorticotropic Hormone