ACTH-like immunoreactivity in the gastrin cell. Independent changes in gastrin and ACTH-like immunoreactivity during ontogeny.
Rat antral gastrin cells have been shown to contain ACTH-like immunoreactivity. Studies on the ontogeny of the antral gastrin cells reveal that these cells start to store gastrin before they contain detectable quantities of ACTH-like immunoreactivity. At no stage studied were duodenal gastrin cells found to contain ACTH-like peptides. The data indicate that the G cells synthetizes and/or releases the two hormonal peptides independently.
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis / Q000276:immunology*; D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology* / Q000378:metabolism; D005755:Gastrins / Q000096:biosynthesis / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008297:Male; D011498:Protein Precursors / Q000096:biosynthesis; D011706:Pyloric Antrum / Q000166:cytology*; D051381:Rats
D005755:Gastrins; D011498:Protein Precursors; D000324:Adrenocorticotropic Hormone