Origin of estrogen in isosexual precocious pseudopuberty due to a granulosa-theca cell tumor.
The purpose of the present study was to quantify the rates of production and to define the mechanism(s) or origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17beta synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen.
D002675:Child, Preschool; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D011629:Puberty, Precocious / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013798:Thecoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology
D004967:Estrogens