Atonia after carbachol microinjections near the locus coeruleus in cats.
The effect of microinjections of carbachol into the dorsolateral pontine tegmentum on the behaviour of cats is investigated. Injections of small amounts (50 and 500ng) of carbachol into the pontine reticular formation induced muscular atonia in otherwise awake animals. The atonia is not due to cholinergic stimulation of the noradrenergic cells of the locus coeruleus or the dorsolateral pons, since the most effective sites were situated ventrally to the locus coeruleus and alpha- and beta-adrenergic blocking agents did not affect the antonia. The results are discussed in view of the postulated role of the locus coeruleus in paradoxical sleep.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002415:Cats; D005260:Female; D008125:Locus Coeruleus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D008845:Microinjections; D009129:Muscle Tonus / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology; D011187:Posture / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D001285:Atropine; D002217:Carbachol; D009638:Norepinephrine