[Effect of different salts and their concentration on polymyxin M biosynthesis by Bac. polymyxa Ross].
The effect of various concentrations of ammonium sulfate, sodium and potassium chlorides and sulfates on biosynthesis of polymyxin M by Bac. polymyxa Ross. on media containing wheet meal as the carbon source was studied. The culture growth, antibiotic accumulation and consumption of the main nutrients was studied as dependent on the level of the salts in the medium. The highest productivity was observed on media with the salt concentrations amounting to 1--2 per cent except sodium sulfate: changes in the concentration of the latter had practically no effect on the activity of the fermentation broth.
D000645:Ammonium Sulfate / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D011113:Polymyxins / Q000096:biosynthesis*; D011189:Potassium Chloride / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013431:Sulfates / Q000494:pharmacology*; D013997:Time Factors
D002712:Chlorides; D003470:Culture Media; D011113:Polymyxins; D013431:Sulfates; D012965:Sodium Chloride; D011189:Potassium Chloride; D000645:Ammonium Sulfate
Vliianie razlichnykh soleĭ i ikh kontsentratsii na biosintez polimiksina M Bac. polymyxa Ross.