Localization and histochemical correlation of 73As by whole-body autoradiography in mice.
Whole-body sagittal sections of mice administered [73As] H3AsO4 intravenously were processed for autoradiography and histochemistry for glucose-6-phosphatase or alkaline phosphatase. The intense localization of 73As in bone, kidney cortex, intestinal mucosa, and hair follicles corresponded exactly with the histochemical activity of glucose-6-phosphatase and alkaline phosphatase in sections containing no arsenic. The activity of glucose-6-phosphatase was inhibited in all of these sites in sections containing arsenic.
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001151:Arsenic / Q000378:metabolism* / Q000494:pharmacology; D001345:Autoradiography; D005952:Glucose-6-Phosphatase / Q000032:analysis / Q000037:antagonists & inhibitors; D008297:Male; D008722:Methods; D051379:Mice; D011868:Radioisotopes; D014915:Whole-Body Counting
D011868:Radioisotopes; D000469:Alkaline Phosphatase; D005952:Glucose-6-Phosphatase; D001151:Arsenic