[Cardioprotection by oral application of the calcium antagonist fendiline. Prevention of isoproterenol-induced myocardial necroses in rats (author's transl)].
1. N-(2-Benzhydryl-ethyl)-N-(1-phenyl-ethyl)-amine hydrochloride (fendiline, Sensit) -- in accordance with its characteristics as a Ca++-antagonist -- shows a strong cardioprotective effect in rats against isoproterenol-induced myocardial necroses. 2. Fendiline is effective via oral administration. 3. The protective effect of fendiline on the myocardium is demonstrated by means of histopathological and histoenzymatic techniques. 4. A particularly reliable method of quantifying the cardio-protective effect of a drug has proven to be the measurement of mitochondrial enzyme activity (cytochrome oxidase, succinate dehydrogenase) using histoenzymatic microphotometry.
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003576:Electron Transport Complex IV / Q000032:analysis; D007545:Isoproterenol; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D009336:Necrosis; D010627:Phenethylamines / Q000627:therapeutic use*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000032:analysis
D010627:Phenethylamines; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D007545:Isoproterenol; D002118:Calcium
Kardioprotektion durch perorale Anwendung des Calcium-Antagonisten Fendilin. Verhütung isoproterenol-bedingter Myokardnekrosen bei Ratten