title: Regions of cerebral ischemia located by pyridine nucleotide fluorescence.
abstract: The fluorescence of the reduced form of the endogenous pyridine nucleotide nicotinamide adenine dinucleotide was used to map regions of ischemia in cat brain. A remarkably microheterogeneous pattern of increased fluorescence resulted from a critical level of incomplete cerebral ischemia. The fluorescence pattern suggests that ischemia occurs initially in microwatershed zones between penetrating cerebral arteries.
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002415:Cats; D002560:Cerebrovascular Circulation; D007511:Ischemia / Q000378:metabolism* / Q000503:physiopathology; D008856:Microscopy, Fluorescence; D009243:NAD / Q000378:metabolism*
chemical_list: D009243:NAD