The effect of dihydroxy-2-aminotetraline (DATs) on dopamine and beta type adenylate cyclases.
A number of DATS have been studied for agonist activity with dopamine (DA) and beta (beta) type adenylate cyclases and the most potent ones were found among the 6,7-DATs and the 5,6-DATs, respectively. None of the compounds tested possessed antagonist activity. The observed activities were not expected on the basis of structural analysis of model compounds such as apomorphine and 6,7-dihydroxy-1-benzyltetrahydroisoquinoline. A new view was constructed which suggests that the nitrogens of the DAT compounds were positioned better than those of the model compounds with regard to their binding sites.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D066298:In Vitro Techniques; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011954:Receptors, Dopamine; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D000262:Adenylyl Cyclases; D001058:Apomorphine