[Enzymes of the pentose phosphate pathway in the brains of rats during long-term deprivation of the paradoxical stage of sleep].
The selective paradoxical sleep (PS) deprivation in rats entailed during first 2 days a drop in activity of glucose-6-phosphatehydrogenase by 80 and 60%, and of 6-phosphogluconatdehydrogenase -- by 20--35 and 40--50% in the brain-stem and the cortex, respectively. Activity of the transketolase decreased by 27--29% on the 2nd day of PS deprivation only. On the 4th day, normalizing of activity of all the enzymes under study except transketolase, was observed in both regions of the brain. The consumption of riboso-5-phosphate by the homogenate and level of phosphoketopentoses formation in it reflected, mainly, the dynamics of transketolase activity changes.
D000818:Animals; D001933:Brain Stem / Q000201:enzymology* / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology* / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007661:Ketoses / Q000096:biosynthesis; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D012267:Ribosemonophosphates / Q000378:metabolism; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000502:physiology*; D013997:Time Factors; D014174:Transketolase / Q000378:metabolism
D007661:Ketoses; D012267:Ribosemonophosphates; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase
Fermenty pentozofosfatnogo puti v golovnom mozge krys pri dlitel'nom lishenii paradoksal'noĭ fazy sna.