Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis.
Leukemia-prone hairless (HRS/J; hr/hr) mice had significantly higher leukemia virus titers than did the leukemia-resistant nonmutants (hr/ + and +/+). This difference was ascribed to the allelic substitution at a single gene locus; at 6 months of age it averaged 13-fold, immediately preceding the large divergence in leukemia incidence between the mutant and nonmutant mice.
D000483:Alleles; D000818:Animals; D005796:Genes; D009052:Leukemia Virus, Murine / Q000302:isolation & purification*; D007942:Leukemia, Experimental / Q000209:etiology / Q000235:genetics*; D008297:Male; D051379:Mice; D008819:Mice, Nude / Q000382:microbiology