title: A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.
abstract: Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D002645:Chickens; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C / Q000378:metabolism; D008819:Mice, Nude / Q000378:metabolism; D009103:Multiple Sclerosis / Q000382:microbiology* / Q000635:transmission; D009186:Myelin Sheath / Q000201:enzymology / Q000254:growth & development*; D051381:Rats
chemical_list: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases