title: Effect of lead ingestion on vitamin D3 metabolism in Japanese quail.
abstract: Immature female Japanese quail were given either lead acetate or sodium acetate in the drinking water for 15 days. In vitro kidney production of 1, 25- and 24-25- dihydroxyvitamin D3 from tritiated 25-hydroxyvitamin D3 was measured. At all 3 dose levels of lead acetate (0.32, 3.2 and 32 mg Pb/ml), in vitro kidney production of 1,25-(OH)2D3 was increased significantly compared to control levels treated with sodium acetate. Lead treatment had no significant effect on plasma calcium and inorganic phosphate levels.
mesh_terms: D000818:Animals; D002762:Cholecalciferol / Q000378:metabolism*; D003370:Coturnix; D005260:Female; D006900:Hydroxylation; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000494:pharmacology*
chemical_list: D002762:Cholecalciferol; D007854:Lead