Antiviral activity of bovine interferons on primate cells.
Potent preparations of bovine leucocyte and fibroblast interferons had substantial antiviral activity on monkey cells and low activity on human cells. Thus, interferon from a 'lower' phylogenetic species can have considerable antiviral activity in primate cells, but not all primate cells are equally sensitive.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004686:Encephalomyocarditis virus / Q000187:drug effects* / Q000254:growth & development; D005347:Fibroblasts / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000378:metabolism; D010802:Phylogeny; D013045:Species Specificity; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects
D007372:Interferons