Inhibition of binding of corticotropin-(1-24)-tetracosapeptide (Synacthen) to membrane receptors of adrenal cortex by cortisol.
The binding of Synacthen to partially purified bovine adrenocortical plasma membranes was shown to be inhibited by cortisol. The findings suggest that cortisol is involved in a peripheral feedback mechanism for the control of its release.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003366:Cosyntropin / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D011956:Receptors, Cell Surface / Q000187:drug effects*
D011956:Receptors, Cell Surface; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone