Investigations into the effects of ACTH on the half-life of mitochondrial proteins in the rat adrenal cortex.
ACTH elongates the half-life of the mitochondrial proteins from the rat adrenal cortex, and chloramphenicol inhibits this effect of ACTH. The hypothesis is advanced that the ACTH-provoked stabilization of the adrenocortical mitochondrial proteins requires continuous mitochondrial DNA-dependent protein synthesis.
D000302:Adrenal Cortex / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D011506:Proteins; D002701:Chloramphenicol; D000324:Adrenocorticotropic Hormone