Conjugated catechol derivatives in a transplantable islet cell tumour of the golden hamster.
Two glucuronidated catechol have been identified in a transplantable islet cell tumour of the golden hamster, i.e. dopamine-4-O-glucuronide and 3-methoxytyramine-4-O-glucuronide. L-dopa is rapidly metabolized in the tumour to one or both of these glucuronides. Incubation of tumour homogenates in the presence of beta-glucuronidase shows that dopamine-4-O-glucuronide is present in the tumour in extremely high concentrations.
D007516:Adenoma, Islet Cell / Q000032:analysis*; D000818:Animals; D002396:Catechols / Q000032:analysis*; D002854:Chromatography, Paper; D006224:Cricetinae; D004298:Dopamine / Q000032:analysis; D005965:Glucuronates / Q000032:analysis*; D005966:Glucuronidase / Q000494:pharmacology; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology; D013058:Mass Spectrometry; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000032:analysis; D013050:Spectrometry, Fluorescence; D014439:Tyramine / Q000031:analogs & derivatives / Q000032:analysis
D002396:Catechols; D005965:Glucuronates; D007980:Levodopa; D005966:Glucuronidase; D004298:Dopamine; D014439:Tyramine