[Comparative activity of endorphins on the opiate receptors].
Displacement of naloxone from membranes of Rat brain by alpha, beta and gamma-endorphins with and without Na+ in the incubating medium has been studied. beta-endorphin shows a higher affinity for the opiate receptors and a stronger agonist property than morphine. alpha and gamma-endorphins have a much lower affinity than morphine and a marked antagonist characteristic. This study suggests the possibility of naturally occurring antagonists of the opiate receptors.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D004723:Endorphins / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009270:Naloxone / Q000378:metabolism*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone
Activité comparée des endorphines sur le récepteur des opiacés.