Properties of a cell line from human adenocarcinoma of the rectum.
A new, highly differentiated line of cells derived from adenocarcinoma of the rectum (HT55) is described. This line is noteworthy for the following features: 1. The role played in its development by the use of UV-inactivated Sendai virus to attach tumour cell clumps to plastic bottles. 2. Evidence that it produces RNA-containing material of density 1-5--1-16 g/ml. 3. Induction of bone formation in the stroma when grown in athymic mice. 4. Stimulation of primary CBA mouse embryo fibroblasts to form a transient nodule when mixed with them and injected into adult CBA mice. The karyotype and growth-cycle characteristics of the line are described.
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002449:Cell Aggregation; D002455:Cell Division; D002460:Cell Line; D002875:Chromosomes / Q000648:ultrastructure; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D010222:Parainfluenza Virus 1, Human / Q000302:isolation & purification; D012004:Rectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013539:Simian virus 40 / Q000302:isolation & purification; D014183:Transplantation, Heterologous
D002272:Carcinoembryonic Antigen