[Participation of histamine in activating the hypothalamo-hypophyseo-adrenal system during stress].
In 289 male rats, accumulation of histamine in diencephalon, augmentation of activity in the hypothalamus, and increase of the ACTH content in the hypophysis and 11-OCS in adrenal and plasma were revealed under a functional stress for the hypothalamo-hypophyseal-adrenal system (HHAS). Further accumulation of histamine was associated with increased secretion of CRF, ACTH, and 11-OCS. Blocking of histamine by diphenylhydramine hydrochloride (10.0 mg/kg i. p. -- 30 min before the experiment) depressed the rate and intensity of the initial reaction of HHAS activation.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D006632:Histamine; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone
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