title: Worldwide controversies in gestational trophoblastic neoplasms.
abstract: This article reviews worldwide controversies concerning gestational trophoblastic neoplasms (hydatidiform mole, invasive mole, and choriocarcinoma). The epidemiology, endocrinology, histopathologic grading, classification, diagnosis, treatment, management and follow-up (including chemotherapy, irradiation, and immunotherapy) of gestational trophoblastic neoplasms - particularly molar pregnancies - are discussed; and ways to help create a standardized classification system and provide optimal treatment for each type of patient are suggested.
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy / Q000628:therapy; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000145:classification / Q000188:drug therapy / Q000276:immunology; D014594:Uterine Neoplasms / Q000145:classification / Q000188:drug therapy / Q000276:immunology / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin; D003609:Dactinomycin; D008727:Methotrexate