[Effect of the nature of the nutrition and of the functional state of the hypophyseal-adrenal system on the "convulsion readiness" of the body].
The effect of some amino acids, succinate and different doses of ACTH on the convulsion response readiness of the organism under the action of a strong sound stimulant was studied. With enrichment of the ration with glutamic acid and also following a parenteral introduction of large doses of succinate a definite protective effect was revealed and, conversely, administration of ACTH (intramuscularly, for 7 day in a dose of 5 Units per 100 g of body weight) increased the convulsion response readiness of the organism. A possible mechanism underlying the detected changes in the convulsion response readiness of the organism under the active factors under study are discussed.
D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D008297:Male; D008715:Methionine / Q000494:pharmacology; D009747:Nutritional Physiological Phenomena; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D012640:Seizures / Q000378:metabolism / Q000503:physiopathology*; D013386:Succinates / Q000494:pharmacology; D013997:Time Factors
D005971:Glutamates; D013386:Succinates; D006639:Histidine; D000324:Adrenocorticotropic Hormone; D008715:Methionine; D005998:Glycine
K voprosu o vliianii kharaktera pitaniia i funktsional'nogo sostoianiia gipofizarno-nadpochechnikovoĭ sistemy na "sudorozhnuiu gotovonost organizma'"