Nerve, muscle, and serotonin.
Effects of serotonin one neuromuscular transmission and muscle contraction were studied in the tibialis anterior of rabbits. Serotonin antagonised the Mg++-induced block of transmission, and also provided dual effects on the curare-induced block, anti-curare phase followed by curare-potentiating phase. Independent of transmission processes, serotonin caused a reduction in twitch tension, mainly associated with decreased acceleration of twitch development. These serotonin actions were independent of vascular changes; pharmacological mechanisms are discussed in comparison with those of adrenaline and isoprenaline. A possible role of serotonin in causing a myopathy is proposed.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D003472:Curare / Q000037:antagonists & inhibitors; D004837:Epinephrine / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008274:Magnesium / Q000037:antagonists & inhibitors; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000098:blood supply; D009469:Neuromuscular Junction / Q000187:drug effects*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D012701:Serotonin; D003994:Bucladesine; D003472:Curare; D008274:Magnesium; D007545:Isoproterenol; D004837:Epinephrine