Polychlorinated biphenyl(s) as a promotor in experimental hepatocarcinogenesis in rats.
The effects of dietary polychlorinated biphenyls (PCBs) on hepatocarcinogenesis in female rats of Donryu strain receiving 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) were investigated. Oral administration of PCBs after administration of 3'-Me-DAB resulted in a high incidence (64%) of hepatocarcinoma. In contrast, administration of a similar amount of PCBs before, or together with 3'-Me-DAB did not induce hepatic tumors. Administration of a slightly larger amount of PCBs alone did not induce liver tumors, while administration of a slightly larger amount of 3'-Me-DAB alone caused only a low incidence (13%) of hepatocarcinoma. These results strongly suggest that PCBs exert a potent promoting action in experimental azo dye hepatocarcinogenesis.
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D004357:Drug Synergism; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D004124:p-Dimethylaminoazobenzene
D004124:p-Dimethylaminoazobenzene; D011078:Polychlorinated Biphenyls