title: Localization of gene functions in polyoma virus DNA.
abstract: Polyoma virus mutants of four functionally distinct groups have been mapped by the marker rescue technique using restriction enzyme fragments of wild-type viral DNA. Nontransforming host-range mutants map in the proximal part of the early region of the viral genome. The same DNA fragment that restores a normal host range also restores normal transforming ability to these mutants. ts-25D, a temperature-sensitive (ts)-a class mutant, maps in the distal part of the early region. ts-3 and ts-1260 map in the proximal and distal parts of the late region, respectively.
mesh_terms: D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000096:biosynthesis; D005796:Genes; D011118:Polynucleotide Ligases; D011120:Polyomavirus
chemical_list: D004279:DNA, Viral; D004262:DNA Restriction Enzymes; D011118:Polynucleotide Ligases