[Cytochemical aspects of human polynuclear neutrophils under the in vitro and in vivo action of TRH].
A TRH fixation in vitro occurs at the level of the human polynuclear neutrophil, which suggests putative membrane receptor (s) for the hypothalamic hormone. After TRH administration, enzyme modifications (myeloperoxydase, alkaline phosphatase) and metabolism changes (PAS, Sudan black) happen in vivo within the neutrophil, showing a functional activation of that blood cell. Two processes may be considered to explain those data: 1) the TRH is directly fixed, as observed in vitro; 2) a mediate hormone (TSH, T4, T3) is released capable of binding the granulocyte membrane.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000235:genetics; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D006003:Glycogen; D010544:Peroxidases; D009195:Peroxidase; D000469:Alkaline Phosphatase
Aspects cytochimiques du polynucléaire neutrophile humain sous l'effet de la TRH, in vitro et in vivo