Stimulation of a reconstituted, microsomal NADH oxidase system by carboquone, a quinoid anticancer chemical.
Carboquone was found to greatly stimulate the aerobic NADH oxidation in the presence of both the partially purified NADH-cytochrome b5 reductase and cytochrome b5 prepared from hepatic microsomes by acting as an electron carrier from cytochrome b5 to molecular oxygen. Other quinoid anticancer chemicals, mitomycin-C, adriamycin, and daunomycin practically failed to do so.
D000818:Animals; D001389:Azirines / Q000378:metabolism*; D002225:Carbazilquinone / Q000378:metabolism*; D003579:Cytochrome Reductases / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism; D004579:Electron Transport; D008862:Microsomes, Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013268:Stimulation, Chemical
D001389:Azirines; D003580:Cytochromes; D009243:NAD; D002225:Carbazilquinone; D003579:Cytochrome Reductases