Aniridia, cataracts, and Wilms' tumor in monozygous twins.
We studied the first instance of aniridia-Wilms' tumor syndrome in twins who were mentally retarded. Both of them had congenital aniridia, cataracts, and glaucoma; only one subsequently developed a Wilms' tumor. A two-allele, two-step mutation is the most likely explanation of this genetically abnormal syndrome in twins. The aniridia-Wilms' tumor syndrome in twins further documents the relationship of teratogenic malformations and neoplasias.
D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000150:complications* / Q000151:congenital / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D005901:Glaucoma / Q000151:congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000150:complications; D007498:Iris / Q000002:abnormalities*; D008297:Male; D009154:Mutation; D010375:Pedigree; D011247:Pregnancy; D014430:Twins, Monozygotic; D009396:Wilms Tumor / Q000150:complications*