Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells.
Normal cells in culture have membrane receptors for epidermal growth factor (EGF); EGF stimulates cells to divide by binding to these receptors. Cells transformed by murine and feline sarcoma viruses rapidly lose the ability to bind EGF, whereas cells transformed by the DNA tumour viruses, polyoma and SV40, or infected with non-transforming RNA tumour viruses have normal levels of functional EGF receptors. The results suggest that a product of the sarcoma virus genome specifically changes cell EGF receptors; the sarcoma gene product may, then, be functionally related to EGF.
D001665:Binding Sites; D002460:Cell Line; D002462:Cell Membrane / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017988:Gammaretrovirus; D006133:Growth Substances / Q000378:metabolism*; D006378:Helper Viruses; D007700:Kinetics; D008979:Moloney murine leukemia virus; D009858:Oncogenic Viruses; D011120:Polyomavirus; D011955:Receptors, Drug / Q000378:metabolism*; D005253:Sarcoma Viruses, Feline; D009053:Sarcoma Viruses, Murine; D013539:Simian virus 40; D013045:Species Specificity; D013997:Time Factors; D014764:Viral Proteins / Q000378:metabolism
D006133:Growth Substances; D011955:Receptors, Drug; D014764:Viral Proteins