Free radical intermediates produced by autoxidation of 1,8-dihydroxy-9-anthrone (dithranol) in pyridine.
The autoxidation of the antipsoriatic agent dithranol, monitored by an ESR-spectrometer, proceeds through several free radical intermediates. The initial radical, attacking a bulky spin trapping agent in a sterically comparatively hindered constellation, may be the active therapeutic form of dithranol.
D000873:Anthracenes; D000875:Anthralin; D055598:Chemical Phenomena; D002621:Chemistry; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D010084:Oxidation-Reduction; D011725:Pyridines; D013113:Spin Labels
D000873:Anthracenes; D005609:Free Radicals; D011725:Pyridines; D013113:Spin Labels; D000875:Anthralin