[Activity of Na, K-ATPase and the enzymes of intermediate metabolism in the brains of rats exposed to electroshock].
Activity of Na, K -ATPase, acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) in the fractions of the rat brain and spinal cord tissue were studied in rats during a single electroshock (ES) and 5 and 30 minutes after it. GAD activity of the synaptosome fraction was shown to decrease insignificantly, but activity of AChE, Na, K -ATPase and possibly of proteolytic enzymes increased 5 minutes after electroshock and became normal in 30 minutes. It is supposed that the revealed inhibition of Na, K -ATPase activity in the "synaptosomes" of the rat brain cortex could be of pathogenetic significance in the origination of the convulsive process.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002262:Carboxy-Lyases / Q000378:metabolism*; D002490:Central Nervous System / Q000201:enzymology*; D004597:Electroshock; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D051381:Rats; D012640:Seizures / Q000201:enzymology* / Q000209:etiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013116:Spinal Cord / Q000201:enzymology; D013997:Time Factors
D000110:Acetylcholinesterase; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase; D000254:Sodium-Potassium-Exchanging ATPase
Aktivnost' Na, K-ATF-azy i fermentov mediatornogo obmena v mozge krys pri élektroshoke.