Effect of prostaglandin E1 on rat gastric motility and cyclic nucleotide content.
Administration of exogenous prostaglandin E1 resulted in an increase in contractility of rat fundic muscle measured in vivo; a significant decrease in fundic tissue levels of cyclic- adenosine monophosphate and a significant increase in cyclic-guanosine monophosphate.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D013270:Stomach
D009712:Nucleotides, Cyclic; D011458:Prostaglandins E; D000242:Cyclic AMP; D006152:Cyclic GMP