Unusual postirradiation sarcoma of chest wall.
This paper reports a sarcoma of the chest wall following postoperative radiation therapy for breast carcinoma. A total of 9346 rads was delivered at a 2-cm tissue depth from two treatment courses separated by a five-year interval. The sarcoma appeared 16 years following the initial radiation course. The existence of two mesenchymal elements in the lesion led to the final diagnosis of malignant mesenchymoma. Criteria for evaluating a possible radiation-induced malignancy are discussed.
D001943:Breast Neoplasms / Q000532:radiotherapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000532:radiotherapy; D002813:Chondrosarcoma / Q000209:etiology / Q000473:pathology; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology / Q000473:pathology; D006801:Humans; D008637:Mesenchymoma / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D013899:Thoracic Neoplasms / Q000209:etiology / Q000473:pathology*; D013997:Time Factors