title: Cyanamide mediated syntheses under plausible primitive earth conditions. I. The synthesis of P1, P2 dideoxythymidine 5'-pyrophosphate.
abstract: When an aqueous solution (pH 7.0) of deoxythymidine 5'-phosphate, 4-amino-5-imidazolecarboxamide and cyanamide was dried and heated for 18 h at 60 degrees C, P1, P2-dideoxythymidine 5'-pyrophosphate (I) was formed in a 58% yield. Oligonucleotides were not detected in the reaction product. Under conditions employed in the above reaction, (I) was shown to be stable. In prebiotic polymerization reactions employing deoxythymidine 5'-triphosphate as the polymerizing species, (I) could therefore function as a primer and minimize the formation of cyclic nucleotides.
mesh_terms: D000588:Amines; D000620:Aminoimidazole Carboxamide; D000643:Ammonium Chloride; D055598:Chemical Phenomena; D002621:Chemistry; D003486:Cyanides; D011756:Diphosphates; D006358:Hot Temperature; D009841:Oligonucleotides; D013942:Thymine Nucleotides
chemical_list: D000588:Amines; D003486:Cyanides; D011756:Diphosphates; D009841:Oligonucleotides; D013942:Thymine Nucleotides; D000643:Ammonium Chloride; D000620:Aminoimidazole Carboxamide