Type C RNA virus expression in systemic lupus erythematosus. New Zealand mouse model and human disease.
An antigen recognized by antisera produced against p30 (core) proteins of the four chief groups of mammalian type C viruses (murine, feline, RD-114 related to endogenous primate, and infectious primate group) is located in an immune-complex pattern in some renal glomeruli of human SLE patients with lupus proliferative glomerulonephritis but is not detected in normal or pathological control human kidneys. This antigen cross-reacts with p30 interspecies determinants shared by the four chief virus groups and cross-reacts with a partially purified antigen extracted from human SLE spleen. The human SLE spleen antigen cross-reacts with p30 group antigen of RD-114 virus but not of feline or murine viruses. Some host immunoglobulins eluted from a human SLE kidney by acid-buffer show antibody-like activity against p30 group antigen of RD-114 virus but not of simian, feline, or murine viruses.
D000818:Animals; D000956:Antigens, Viral; D003429:Cross Reactions; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D051379:Mice; D008814:Mice, Inbred NZB; D012328:RNA Viruses / Q000302:isolation & purification*; D012190:Retroviridae / Q000302:isolation & purification*; D013154:Spleen / Q000276:immunology; D014020:Tissue Extracts
D000956:Antigens, Viral; D014020:Tissue Extracts