Effect of immune manipulation on natural immune responses to murine mammary tumor antigens.
The virus-host relationship in BALB/cfC3H virgin female mice neonatally infected with an oncogenic virus (mammary tumor virus) (MuMTV) was significantly altered by a brief immunosuppressive treatment during young adult life. Natural immune responses were augmented and changed. The ability of lymphoid cells to attack target cells expressing MuMTV-associated antigens was significantly increased, and a new component, a non-T-cell reactivity, was added to the T-cell reactivity found in normal females. Serum blocking factors were both quantitatively and qualitatively altered.
D000818:Animals; D000831:Animals, Newborn; D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral; D000956:Antigens, Viral / Q000008:administration & dosage; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001667:Binding, Competitive; D005260:Female; D007109:Immunity; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000209:etiology / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000961:Antilymphocyte Serum