Prolyl hydroxylase activity in human normal skins and post-burn scars.
Post-burn granulation tissues showed an extraordinary high prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase) activity, 25 to 50 times higher than the mean value of human normal skins from the frontal thighs of 15 subjects, 385 +/- 247 (S.D.) cpm/min/g of wet weight tissue. The activity in the scars decreased sharply within 4 to 5 months, and then gradually decreased to the normal range after 2 years or so. Well-aged scars tended to show lower values than the mean value of normal skins.
D000293:Adolescent; D000328:Adult; D002056:Burns / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000201:enzymology*; D005260:Female; D006097:Granulation Tissue / Q000201:enzymology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D012867:Skin / Q000201:enzymology*; D013997:Time Factors
D011393:Procollagen-Proline Dioxygenase