title: Colorectal carcinoma in adolescents implications regarding etiology.
abstract: Between October, 1974 and December, 1976, 13 adolescent patients with far-advanced, poorly differentiated colorectal carcinoma had been referred to a pediatric cancer center. All patients received chemotherapy with vincristine, methyl-CCNU and 5-fluorouracil. Five of 13 patients are living, one of whom remains disease-free after 12 months of chemotherapy. Four of the patients were from urban areas and nine from rural areas. One of four from urban areas had intimate exposure to chemicals used in the production of cotton and soy beans. Eight of nine patients from rural areas also had exposure to farm or agricultural chemicals, and three of these patients were intimately involved with the spraying operations. Suggestions regarding etiology and causative factors for the development of carcinoma of the colon in adults have previously been advanced. Results of these studies suggest that alternate etiologies must be suggested for adolescent colorectal carcinoma.
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D002648:Child; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008130:Lomustine / Q000627:therapeutic use; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D008130:Lomustine; D005472:Fluorouracil