Interferon enhances T cell mediated cytotoxicity of H-2 compatible target cells infected with UV-inactivated herpes simplex virus.
Mouse L-cells infected with UV-inactivated HSV could serve as suitable targets for monitoring H-2 restricted cytotoxicity mediated by HSV-immune T cells. Cytotoxic potential of immune T cells for H-2 compatible targets exposed to UV-inactivated HSV was enhanced if the later were pretreated with mouse interferon.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006183:H-2 Antigens; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D018139:Simplexvirus / Q000276:immunology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology*; D014466:Ultraviolet Rays
D006183:H-2 Antigens; D007372:Interferons