Antiviral activity of carbopol, a cross-linked polycarboxylate.
Carbopol, a polymer of acrylic acid cross-linked with allylsucrose, was found to impart resistance to virus infection in mice which received an intraperitoneal injection of the polycarboxylate 1 or 4 days before either intravenous vaccinia virus challenge or intranasal herpes simplex virus challenge. An interferon-like substance was detected in the blood stream 20-40 hours after the intraperitoneal injection of carbopol. The antiviral activity of this cross-linked polycarboxylate could be due to activation of peritoneal macrophages and/or interferon production.
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001202:Ascitic Fluid / Q000166:cytology; D002264:Carboxylic Acids / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004660:Encephalitis / Q000517:prevention & control*; D005260:Female; D006561:Herpes Simplex / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007372:Interferons / Q000096:biosynthesis; D051379:Mice; D011145:Polyvinyls / Q000627:therapeutic use*; D018139:Simplexvirus / Q000187:drug effects; D013623:Tail; D014615:Vaccinia / Q000517:prevention & control*; D014616:Vaccinia virus / Q000187:drug effects
D000998:Antiviral Agents; D002264:Carboxylic Acids; D011145:Polyvinyls; D007372:Interferons