[Carbohydrate metabolism in the kidneys of rats with dimethylnitrosamine-induced tumors].
Under study was anaerobic glycolysis, the activity of hexokinase, lactate dehydrogenase, gluco-6-phosphatase in rat kidneys in dimethylnitrosamine (DMNA) induced tumors in them. DMNA was administered perorally in the dosage of 10 mg/Kg during 4 weeks (25 mg per rat). Following 8 months tumors developed in the renal cortical substance. The tumor tissue, the renal cortical substance adjacent to the tumor, and the renal cortical substance without macroscopic tumor signs have been studied. An increased glycolysis, hexokinase and lactatedehydrogenase activity were noted, whereas the activity of glucoso-6-phosphatase was diminished in all tissues under examination. Changes of all indices were mostly pronounced in tumor tissue and least significant--in the renal cortical layer without any macroscopic tumor signs.
D000818:Animals; D004128:Dimethylnitrosamine; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism; D009602:Nitrosamines; D051381:Rats
D009602:Nitrosamines; D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D005952:Glucose-6-Phosphatase; D004128:Dimethylnitrosamine
Uglevodnyĭ obmen v pochkakh krys pri opukholiakh, indutsirovannykh dimetilnitrozaminom