[Hepatic fibrosis--mechanism, dynamics and clinical consequences (author's transl)].
Hepatic fibrosis may result from collapse after hepatocellular necrosis or from new formation of connective tissue. Fibroplasia, particularly within the lobular parenchyma, is a dynamic process. Newer cellular and biochemical investigations clarified its various steps. The process begins with stimulation of cells to connective tissue formation and can be divided into (1) intracellular synthesis, (2) extracellular maturation, and (3) collagen breakdown. The turnover of the connective tissue in the liver is conspicuously increased in chronic hepatitis of any type, as indicated by an elevation of several cellular and metabolic parameters. They are particularly raised in chronic hepatitis and in alcoholic liver injury. Further development of these parameters in the future should facilitate the analysis of the dynamics of fibroplasia. The strongest stimuli for hepatic fibroplasia are hepatocellular necrosis and inflammation, but ethyl alcohol and steatosis are also stimulating, though to a lesser degree. This explains the particular elevation of the fibroplastic parameters in alcoholic hepatitis. It points, however, also to the possibility that cirrhosis might develop without significant hepatocellular necrosis and inflammation. Perihepatocellular, periductular, and septal fibrosis are the functionally most important localizations leading to additional hepatic injury. The initiation of these types of fibrosis by liver injury points to a vicious circle. Specific anti-fibroplastic therapy is still in infancy.
D002908:Chronic Disease; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects; D006505:Hepatitis / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008103:Liver Cirrhosis / Q000378:metabolism; D003012:Microbial Collagenase / Q000378:metabolism; D011392:Proline / Q000032:analysis
D000431:Ethanol; D003094:Collagen; D011392:Proline; D003012:Microbial Collagenase; D006909:Hydroxyproline
Die Leberfibrose--Entstehung, Dynamik und klinische Bedeutung.