Effect of salicylates on cyclic AMP in isolated rat gastric mucosa.
Studies on the cyclic AMP content of isolated rat gastric mucosa have been conducted with sodium salicylate and lysine-acetylsalicylate singly and combined with gastric secretagogues and their antagonists. Both salicylates at a concentration of 1.66 X 10(-2) M increased the amount of cyclic AMP. The increase of gastric mucosal cyclic AMP produced by sodium salicylate was diminished by prostaglandin E1 (10(-5) M), atropine (10(-6) M) and the H2-antihistamine metiamide (2 X 10(-4) M). Theophylline 3 X 10(-3) M), histamine (10(-3) M) and pentagastrin (10(-6) M) did not enhance the cyclic-AMP-response to salicylate or lysine-acetyl-salicylate.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008785:Metiamide / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*; D012980:Sodium Salicylate / Q000494:pharmacology
D011458:Prostaglandins E; D012459:Salicylates; D008785:Metiamide; D001285:Atropine; D000242:Cyclic AMP; D012980:Sodium Salicylate