Antiviral activity in the rabbit cornea of adenine arabinoside, Ara-A 5' monophosphate, and hypoxanthine arabinoside; and interactions with adenosine deaminase inhibitor.
The multiple microtrephination technique was used in the rabbit cornea to compare the activity against herpes simplex virus (hsv) of adenine arabinoside (ara-A), ara-A 5'monophosphate (ara-AMP) and hypoxanthine arabinoside (ara-Hx), and to determine the effect of addition of adenosine deaminase inhibitor (ADAI) to each. The greatest antiviral activity was shown by ara-AMP, and the least by ara-Hx. ADAI increased the activity of ara-A but had no effect on ara-AMP or ara-Hx.
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D003315:Cornea / Q000382:microbiology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D009824:Ointments; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects / Q000254:growth & development; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014779:Virus Replication / Q000187:drug effects
D058892:Adenosine Deaminase Inhibitors; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009824:Ointments; D009700:Nucleoside Deaminases; D014740:Vidarabine