MSH/ACTH4-10 influences on the CAR in human subjects: a negative finding.
Twenty normal, male, paid volunteers were randomly assigned to MSH/ACTH4-10 or diluent control groups. Following a subcutaneous injection of either 30 mg MSH/ACTH4-10 or diluent, all subjects were placed in an active conditioned avoidance response situation where they learned to avoid a painful electric shock by pressing a key during a safe interval between a warning signal (light) and shock onset. MSH/ACTH4-10 did not influence any parameter of the acquisition or extinction process.  The between subjects' variability of autonomic variables was significantly less for the MSH/ACTH4-10 group. Results indicate that inhibition of extinction of conditioned avoidance responding does not generalize across species from rat to man.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D001810:Blood Volume / Q000187:drug effects; D002986:Clinical Trials as Topic; D003213:Conditioning, Psychological / Q000187:drug effects; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010919:Placebos
D010446:Peptide Fragments; D010919:Placebos; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones