[Enzootic calcinosis and other plant induced calcinoses (author's transl)].
A review is given of the literature concerning the so-called plant induced calcinosis in animals (tabel I), i.e. diseases which in their patological-anatomical appearance show great similarities with vit. D-intoxication. The etiology of the diseases are discussed in view of the last 5--10 years rapid development of knowledge concerning vit. D3 metabolism. It is pointed out that the most recent results indicate that enzootic calcinosis is caused by a 1,25-dihydrocholecalciferol-glycoside, which is hydrolysed in the intestinal tract. By this reaction 1.25 (OH) 2 cholecalciferol--the biological active metabolite of vit. D3 -- is set free, and thus able to act directly on the intestinal absorption mechanism. By this reaction the point of calcium metabolism regulation is essentially by-passed and calcium and phosphate absorption proceeds essentially out of control, causing hypercalcaemia, hyperphosphataemia, hypersecretion of calcitonin and calcinosis.
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology* / Q000473:pathology; D002762:Cholecalciferol / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D010939:Plant Poisoning / Q000150:complications / Q000662:veterinary*; D013997:Time Factors; D014807:Vitamin D / Q000378:metabolism
D014807:Vitamin D; D002762:Cholecalciferol
Enzootik calcinose og andre planteinducerede calcinoser