title: Epstein-Barr virus in somatic cell hybrids between mouse cells and human nasopharyngeal carcinoma cells.
abstract: Somatic cell hybrids between mouse cells and cells derived directly from NPC biopsies were produced in order to study the association of the Epstein-Barr virus (EBV) genome and the expression of Epstein-Barr nuclear antigen (EBNA) with the human chromosome(s). All attempts to correlate the presence of EBV-DNA and the expression of EBNA with the presence of a particular human chromosome(s) showed that the segregation of EBV-DNA or of EBNA and human chromosomes was dysconcordant. The data, therefore, suggest that in the hybrids studied the presence of EBA-DNA is not determined by the presence of a specific human chromosome.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002459:Cell Fusion; D002460:Cell Line; D002467:Cell Nucleus / Q000276:immunology; D002902:Chromosomes, Human, 16-18; D002904:Chromosomes, Human, 21-22 and Y; D004279:DNA, Viral / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D006822:Hybrid Cells / Q000382:microbiology; D007527:Isoenzymes / Q000032:analysis; D051379:Mice; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000382:microbiology*
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral; D007527:Isoenzymes