title: Accumulation of 99mTc-diphosphonate in four patients with hepatic neoplasm: case reports.
abstract: The accumulation of bone-seeking radiopharmaceuticals in extraosseous lesions has been reported in patients with myocardial infarctions, cerebral infarctions, and some soft-tissue tumors. While the precise mechanisms involved remain uncertain, the spectrum of abnormalities exhibiting such accumulation increases. In our laboratory, 99mTc-diphosphonate concentrated in four hepatic tumors (one cholangiocarcinoma and three metastases from colon carcinoma). This property of phosphate-related radiopharmaceuticals has not been reported previously. Awareness of the possibility of focal diphosphonate accumulation in the liver should help avoid confusion with right lower rib-cage metastasis or pleural effusion.
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D002759:Adenoma, Bile Duct / Q000175:diagnosis; D000368:Aged; D002430:Cecal Neoplasms / Q000175:diagnosis; D003110:Colonic Neoplasms / Q000175:diagnosis; D004164:Diphosphonates; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D004164:Diphosphonates; D013667:Technetium