title: Effects of phosphonoacetic acid on subacute myeloopticoneuropathy virus in vitro and in vivo.
abstract: The effect of phosphonoacetic acid (PAA) in vitro and in vivo on subacute myeloopticoneuropathy (SMON) virus isolated from the spinal fluid of SMON patients was studied. PAA inhibited multiplication of SMON virus in cultures, but it did not show a direct effect on the virus. The drug did not influence the disease when the medication was started from 10 days after infection of suckling mice. However, the drug did elicit a delay in the incubation period.
mesh_terms: D000818:Animals; D002555:Cerebrospinal Fluid / Q000382:microbiology; D006564:Herpesviridae / Q000187:drug effects* / Q000254:growth & development; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000382:microbiology*; D051379:Mice; D009187:Myelitis / Q000188:drug therapy / Q000382:microbiology*; D009902:Optic Neuritis / Q000188:drug therapy / Q000382:microbiology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D013577:Syndrome; D014779:Virus Replication / Q000187:drug effects
chemical_list: D009943:Organophosphorus Compounds; D010746:Phosphonoacetic Acid