title: [Variation of the profile phenotype M of alpha-1-chymotrypsine : trial of interpretation (author's transl)].
abstract: Cross immunoelectrophoresis of serum A1AT (Pi M) shows "frequent" patterns with M2 less than M6 less than M4. Other "particular" patterns were found with M6 greater than M4 and M6 less than M2. The most often found patterns among the Negroid population in our study appeared dissimilar to that found among Caucasians. The "super-gene" concept and the variability of genetic flow may explain this difference. The "particular" patterns are often found in cord blood samples and in patients with hepatocarcinoma. They show similaritis between embryonic and cancerous processes. These different patterns also agree with the "super-gene" concept.
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000235:genetics*; D007560:Cote d'Ivoire; D005796:Genes; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods*; D007123:Immunoelectrophoresis, Two-Dimensional / Q000379:methods; D008113:Liver Neoplasms / Q000097:blood / Q000235:genetics*; D008171:Lung Diseases / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000235:genetics* / Q000378:metabolism
chemical_list: D000515:alpha 1-Antitrypsin
vernacular_title: Variation du profil phénotypique M de l'alpha-1-antitrypsine : essai d'interprétation.