[Effect of estrogens on interaction of calcium ions with mitochondrial membranes].
It has been shown that steroid hormones do not affect the fluorescence parameters in solutions of the complex NADH-Ca. Addition of discoupling concentrations of Ca2+ to the liver mitochondria induced the elimination of pyridine nucleotides. The hormones studied inhibit the oxidation of NAD-dependent substrates, thus suppressing an active transport of Ca2+. An analysis of the effect of steroid hormones on Ca2+ ions transport under succinate oxidation suggests that these hormones affect the polarity of hydrophobic regions of the mitochondria membranes. It is suggested that steroid hormones can perform their regulatory functions by influencing the transport of Ca2+ ions in the living cell.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004054:Diethylstilbestrol / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats
D004967:Estrogens; D009243:NAD; D004997:Ethinyl Estradiol; D004958:Estradiol; D004054:Diethylstilbestrol; D002118:Calcium
Izuchenia vliianiia ĕstrogenov na vzaimodeĭstvie ionov kal'tsiia s membranami mitokhondri.