[Nerve-blocking properties of antibiotics].
Comparative data on the neuroblocking activity of antibiotics of various groups in acute experiments on albino mice and narcotized cats are presented. It was found that according to the impairments in the neuro-muscle conductivity the drugs were arranged in the following descending order: polymyxin B, neomycin, gentamicin, streptomycin, lincomycin and kanamycin. The streptomycin derivatives were approximately 2 times less toxic than streptomycin. The problems of the mode of action of the antibiotics on conductivity of excitation in the neuro-muscle synapses are discussed.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D051379:Mice; D009407:Nerve Block; D009420:Nervous System / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D000900:Anti-Bacterial Agents; D009466:Neuromuscular Blocking Agents
O neĭroblokiruiushchikh svoĭstvakh antibiotikov.