[Effect of thiol-oxidizing agents on several enzymes in rat liver mitochondria].
The sulphydryl groups of nonprotein thiols and proteins of mitochondria, activity of enzymes, oxidative phosphorylation and swelling of these organellas were studied as affected by the thiol-oxidizing agents. Diamide and azoester are shown to oxidize SH-groups of mitochondria, inhibit isocytrate dehydrogenase and succinate: cytochrome oxidation and inhibits energy-dependent swelling of mitochondria. Under the effect of azoester the rate of oxygen consumption by mitochondria increases and there occurs their sharp swelling.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology; D003958:Diamide / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008933:Mitochondrial Swelling / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010545:Peroxides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013384:Succinate Cytochrome c Oxidoreductase / Q000378:metabolism; D013439:Sulfhydryl Reagents
D001391:Azo Compounds; D001593:Benzyl Compounds; D010545:Peroxides; D011506:Proteins; D013439:Sulfhydryl Reagents; D003958:Diamide; D013384:Succinate Cytochrome c Oxidoreductase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005969:Glutamate Dehydrogenase; D005978:Glutathione
Deĭstvie tiol-okisliaiushchikh agentov na nekotorye fermenty mitokhondriĭ pecheni krys