title: Leukemogenicity of clonal isolates of murine leukemia viruses.
abstract: The leukemogenicity of three types of cloned, in vitro grown murine retroviruses was studied. Two Moloney virus clones caused leukemia, as did five clones of the B-tropic endogenous virus of BALB/c mice. Neither of two clones of N-tropic BALB/c virus caused leukemia in Fv-1n/n mice, and the viruses were not recoverable from the animals. The ability to induce leukemia therefore appeared to reside in the genome of at least certain nondefective murine retroviruses.
mesh_terms: D000818:Animals; D009052:Leukemia Virus, Murine / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology*; D008979:Moloney murine leukemia virus / Q000472:pathogenicity