Concerning the independence of the basis of hypertension due to ACTH or renovascular constriction.
Administration of ACTH to four sheep with chronic renovascular hypertension resulted in an increase in blood pressure which was at least as high as that described in normotensive sheep and could be completely accounted for by an increase in cardiac output.
D000305:Adrenal Cortex Hormones / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006977:Hypertension, Renal / Q000378:metabolism / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism; D012083:Renin / Q000097:blood; D012756:Sheep; D012964:Sodium / Q000378:metabolism; D014655:Vascular Resistance / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D011188:Potassium