Biomaterials and collagen synthesis.
A highly reactive biomaterial (clay) and a relatively nonreactive substance (silicone) were implanted separately in primarily closed incisions on the backs of rats. Collagen synthesis was determined in biopsies from each test site after 8 days. The biochemical measurements of collagen synthesis showed a significant correlation with the gross pathologic and histologic findings.
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis*; D005547:Foreign Bodies / Q000473:pathology; D051381:Rats; D012822:Silicon Dioxide / Q000494:pharmacology*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012987:Soil
D001672:Biocompatible Materials; D012987:Soil; D012822:Silicon Dioxide; D003094:Collagen