Hyperinsulinemic hypoglycemia: effect of epinephrine suppression.
The inhibitory effect of epinephrine on basal and tolbutamide-stimulated insulin release was studied in 5 patients with hyperinsulinemic hypoglycemia. Epinephrine inhibited both basal and tolbutamide-induced insulin release in patients with beta-cell adenoma and hyperplasia, but failed to inhibit insulin release in a patient with beta-cell carcinoma. The inhibition of basal insulin with epinephrine was maximum in patients with beta-cell hyperplasia. This differential inhibitory effect of epinephrine on insulin release may prove to be a useful screening test in the preoperative diagnosis of the nature of the lesion producing hyperinsulinemia.
D000236:Adenoma / Q000097:blood; D007516:Adenoma, Islet Cell / Q000175:diagnosis*; D000328:Adult; D002277:Carcinoma / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism*; D006965:Hyperplasia; D007003:Hypoglycemia / Q000097:blood; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D014044:Tolbutamide / Q000494:pharmacology
D007328:Insulin; D014044:Tolbutamide; D004837:Epinephrine