Pars intermedia ACTH and MSH content: effect of adrenalectomy, gonadectomy and a neurotropic (noise) stress.
Pars intermedia (PI) ACTH and melanocyte-stimulating hormone (MSH) content and pars distalis (PD) ACTH concentration were measured following 3 experimentally induced 'perturbations'. The feedback-induced increase in ACTH release following adrenalectomy is not accompanied by a change in PI ACTH and MSH contents, while the feedback-induced increase in gonadotropin secretion following gonadectomy is associated with significant changes in PI ACTH and MSH contents. A well-defined neurotropic (noise) stressor resulted in significant increases in PI ACTH and MSH. A striking finding in all of the studies was a positive correlation between PI ACTH and MSH contents. We conclude that PI ACTH and MSH secretion are altered with feedback-induced alterations in gonadotropin secretion and with neurotropic stressors.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D005260:Female; D006066:Gonads / Q000502:physiology*; D006801:Humans; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis* / Q000378:metabolism; D009622:Noise; D010903:Pituitary Gland, Anterior / Q000032:analysis*; D051381:Rats; D013315:Stress, Psychological / Q000502:physiology*
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones