Schwann cell abnormalities in 2,5-hexanedione neuropathy.
Distinctive cytoplasmic alterations of Schwann cells were observed by electron microscopy in rats and mice with peripheral neuropathy induced by chronic exposure to 2,5-hexanedione. Pronounced enlargement of Schwann cells was due to accumulation of 100 angstrom cytoplasmic filaments and endoplasmic reticulum and was most often observed after 12--15 weeks exposure to 2,5-hexanedione. Examination of teased nerve fibres revealed segmental demyelination and remyelination involving axons of normal diameter as well as giant axons. The filament disorder induced by 2,5-hexanedione administration is not limited solely to axoplasmic contents. Possible mechanisms of demyelination are discussed and the changes are compared to those observed in human neuropathy for which 2,5-hexanedione appears to be the closest experimental model.
D000818:Animals; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000473:pathology; D005727:Ganglia, Spinal / Q000648:ultrastructure; D006588:Hexanones; D007659:Ketones; D051379:Mice; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D009454:Neurofibrils / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D012583:Schwann Cells / Q000648:ultrastructure*; D013116:Spinal Cord / Q000648:ultrastructure
D006588:Hexanones; D007659:Ketones