[Induction of a menadione-dependent respiratory shunt by a platinum complex].
Submitochondrial particles (SMP) from the bovine heart were treated with platinum complex--K [C2H4 PtCl3] (Zeize's salt); there occurred a menadion-dependent shunt, this being expressed in menadion stimulation of oxygen consumption under conditions of electron transport block with rotenon. This effect was observed only with the use in the capacity of a substrate of NAD.N2, but not of succinate. Menadion-dependent respiration induced with Zeize's salt was dicoumarol-sensitive, but was not inhibited by antimycin and cyanide, this differentiating it from menadionreductase shunt in the intact hepatic mitochondria.
D000818:Animals; D003580:Cytochromes / Q000378:metabolism; D004347:Drug Interactions; D004579:Electron Transport / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D010165:Palladium / Q000494:pharmacology; D010984:Platinum / Q000494:pharmacology*; D051381:Rats; D014812:Vitamin K / Q000494:pharmacology*
D003580:Cytochromes; D009243:NAD; D014812:Vitamin K; D010984:Platinum; D010165:Palladium
Induktsiia menadionsavisimogo dykhatel'nogo shunta kompleksom platiny.