title: Ultrastructural localization of rabies virus antigens in infected trigeminal ganglion of hamsters.
abstract: The trigeminal ganglion of hamsters infected with CVS strain of rabies virus was investigated by electron microscopy with peroxidase-labeled antibody. Major localization of virus antigens were the following three types of structures; rabies virion, cytoplasmic inclusion, and ribosomal granules consisting of Nissl body. Rabies virions in neurons were mostly found within the cluster of such ribosome-rich regions suggesting a close relationship between the two in the synthesis of virus antigen. The cytoplasmic inclusion appeared to be derived from ribosomal or allied particles with virus-specific antigens. The significance of results obtained is briefly discussed.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D006224:Cricetinae; D002479:Inclusion Bodies / Q000648:ultrastructure; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure; D009562:Nissl Bodies / Q000648:ultrastructure; D011820:Rabies virus / Q000276:immunology*; D012270:Ribosomes / Q000648:ultrastructure; D012668:Trigeminal Ganglion / Q000032:analysis* / Q000648:ultrastructure; D014276:Trigeminal Nerve / Q000032:analysis*; D014771:Virion
chemical_list: D000956:Antigens, Viral