Collagen prolyl hydroxylase levels in experimental paraquat poisoning.
Collagen prolyl hydroxylase activity was measured in lung, liver, kidney and serum in rats killed on 7 successive days following a single toxic dose of paraquat. The enzyme activity in liver initially fell, then returned to normal, and no change was found in kidney. In contrast a 5-fold rise was observed in lung enzyme level, reaching of maximum on the 5th day. A parallel rise in serum activity was also found. The onset of these enzyme elevations corresponds to the early histological appearance of cellular proliferation in lung alveoli.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008297:Male; D010269:Paraquat / Q000506:poisoning*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D010269:Paraquat