title: Effect of dietary cyclopropene fatty acids on the octadecenoates of individual lipid classes of rat liver and hepatoma.
abstract: The effect of dietary cyclopropene fatty acids on the concentration of octadecenoate chain positional isomers in individual lipid classes of normal liver, host liver, and hepatoma 7288CTC has been determined. The data revealed the following: (a) Saturated and monoene fatty acid percentages of liver phosphatidylcholines and phosphatidylethanolamines were not affected, but the percentage of saturated fatty acids of the triglycerides and cholesteryl esters was increased while the monoene percentages decreased. (b) Oleate to vaccenate percentage ratios, previously shown to be characteristic of individual lipid classes, were completely disrupted. (c) Oleate concentrations of the two major liver phospholipids were elevated, and vaccenate levels were dramatically reduced. (d) Cyclopropene fatty acids appear to inhibit monoene elongation. (e) The elevated concentrations of oleate indicate that an alternate route of oleate biosynthesis must exist if the delta9 desaturation is inhibited by cyclopropene fatty acids as reported previously. (f) In contrast to liver, oleate and vaccenate concentrations in hepatoma were not affected by the dietary cyclopropene fatty acids.
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D003521:Cyclopropanes / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D007536:Isomerism; D050356:Lipid Metabolism; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism; D009829:Oleic Acids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
chemical_list: D003521:Cyclopropanes; D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; D010743:Phospholipids