Tobramycin and neuromuscular transmission in the rat isolated phrenic nerve-diaphragm preparation.
The effects of different concentrations of tobramycin, streptomycin, neomycin and gentamicin on the rat isolated phrenic nerve-diaphragm preparation are reported. Streptomycin, neomycin and gentamicin produced dose-dependent neuromuscular blockade. Tobramycin increased the muscle response at high concentrations (6.4 X 10(-4) - 2.6 X 10(-2) mol litre-1, but had no detectable effect when used in therapeutically recommended concentrations.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009355:Neomycin / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013307:Streptomycin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D014031:Tobramycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009355:Neomycin; D014031:Tobramycin; D013307:Streptomycin