The scintigraphic demonstration of acute myocardial infarcts.
The feasibility of acute infarct scintigraphy for the clinical evaluation of patients with known or suspected acute myocardial infarction is established. Further development of this methodologic approach may result in even better agents for the visualization of infarcts. Radiotracers with high affinity for the infarct, rapid blood clearance, and low concentrations in surrounding organs, such as liver and bone, would be more suitable than available radiopharmaceuticals for acute myocardial infarct scintigraphy. Ultimately, labeling these tracers and ultra-short-lived radionuclides will enable rapid sequential imaging to assess changes in the extent of infarction and to determine the efficacy of therapies aimed at limiting infarct size.
D000208:Acute Disease; D011756:Diphosphates; D006801:Humans; D008631:Mercury Radioisotopes; D009203:Myocardial Infarction / Q000175:diagnosis*; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013667:Technetium; D013752:Tetracycline / Q000378:metabolism; D013997:Time Factors
D011756:Diphosphates; D008631:Mercury Radioisotopes; D013667:Technetium; D013752:Tetracycline