title: [Variation in the toxicity of various silicas in relation to the duration of presence in the body].
abstract: The toxic effect of two forms of sand on the lung was investigated by tracheal injection in Rats. After a latent period with low toxicity, more and more extensive pulmonary lesions, comparable to typical silicotic lesions, appear progressively. On the basis of some observations, the hypothesis is put forward that the impurities present in the dust have a retardative effect.
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012822:Silicon Dioxide / Q000633:toxicity*; D013997:Time Factors
chemical_list: D012822:Silicon Dioxide; D003094:Collagen
vernacular_title: Variation de la nocivité de certaines silices en relation avec leur temps de séjour dans l'organisme.