title: Serological studies with reovirus-like enteritis agent.
abstract: The age distribution of antibody to the human reovirus-like enteritis agent, and to the antigenically related Nebraska calf diarrhea virus (NCDV) was studied in serum specimens obtained from 592 children hospitalized in Boston. Sera were examined for complement-fixation (CF) antibody to the human agent, and for CF and indirect immunofluorescence-staining antibodies to NCDV. The curve of antibody frequency was similar in each of the three assays, showing a steep rise in the 6- to 18-month-old age groups; these results indicate the early acquisition of antibody to the reovirus-like enteritis agent. The majority of children and young adults possessed CF- and immunofluorescence-stainable antibodies. There was a significant association between antibody prevalence data obtained with the human CF antigen and with the two NCDV antigens; this association was closest between the human and NCDV CF antigens.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000906:Antibodies; D000941:Antigens; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D005260:Female; D005455:Fluorescent Antibody Technique; D005759:Gastroenteritis / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012087:Reoviridae / Q000276:immunology; D012088:Reoviridae Infections
chemical_list: D000906:Antibodies; D000941:Antigens