[The lymphocyte. Model for study of cell growth control].
The absence of one essential amino-acid during lymphocyte activation by phytohemagglutinin inhibits the synthesis of macromolecules which should normally occur. The study of the kinetics of macromolecule synthesis and RNA polymerase activity during the relief of inhibition by the addition of the deficient amino-acid, shows that partial activation occurred in spite of the absence of this essential amino-acid. We use this system of reversible inhibition of lymphocyte activation to study the role of nuclear proteins in the regulation of cell growth.
D000601:Amino Acids, Essential / Q000172:deficiency; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007700:Kinetics; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008960:Models, Psychological; D009367:Neoplasm Staging; D009698:Nucleoproteins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D012318:RNA Polymerase I / Q000096:biosynthesis
D000601:Amino Acids, Essential; D037102:Lectins; D009698:Nucleoproteins; D012318:RNA Polymerase I
Le lymphocyte. Système modèle pour l'étude du contrôle de la croissance cellulaire.