title: Tumor immunity: relevance of animal models to man.
abstract: The conclusions that can be drawn from results of animal experiments often provide important insights into the mechanisms of human disease and the rationale for effective therapy. A few years ago, animal models of tumor immunity revealed that both specific and nonimmune specific stimulation of the immune system could effectively prevent or cure cancer. Extensive clinical studies have not convincingly demonstrated that the results with the animal models used are reproducible in humans. New animal models more closely reflecting the properties of human cancer are needed to determine the applicability of cancer immunotherapy to man.
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000276:immunology; D006168:Guinea Pigs; D006649:Histocompatibility Antigens; D006801:Humans; D007109:Immunity; D007167:Immunotherapy; D007938:Leukemia / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D012509:Sarcoma / Q000276:immunology
chemical_list: D001500:BCG Vaccine; D006649:Histocompatibility Antigens