title: Disulfiram neuropathy.
abstract: A 35-year-old man developed a distal sensorimotor polyneuropathy after taking disulfiram, 500 mg daily for five months. His symptoms improved after the drug therapy was discontinued. Clinical, electrophysiological, and pathological observations during the acute stage and during recovery suggest that disulfiram produces a distal axonopathy.
mesh_terms: D000328:Adult; D004221:Disulfiram / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D013497:Sural Nerve / Q000648:ultrastructure
chemical_list: D004221:Disulfiram