[Changes in several lipid metabolism indices following death and resuscitation].
The lipolytic activity in the adipose tissue, unesterified fatty acids (UFA) in the blood and adipose tissue, as well as ketone bodies and beta-lipoproteins in the blood were determined in dogs during dying of acute blood loss and the restorative period after the revival of the organism. During agony the activation of lipolysis in the adipose tissue, a decrease of UFA and beta-lipoproteins and an increase of ketane bodies contents in the blood were detected. At the end of the third minute of clinical death there occurred a depression of lipolysis and an increase of UFA content in the adipose tissue. One hour after the revival of the organism the blood UFA content and beta-proteins decrease, but the ketone bodies content rises; simultaneously there occurs some reduction of lipolytic activity of the adipose tissue. At the late postreanimation period (in 1, 3, and 7 days) an activation of lipolysis in the adipose tissue and an increase of UFA, ketone bodies, and beta-lipoproteins content in the blood was noted. The adipose tissue UFA content was low during the postreanimation period. The given results have shown that the changes in the lipid metabolism could play some role in the pathogenesis of non-reversibility during dying and after the revival of the organism.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007657:Ketone Bodies / Q000097:blood; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D011180:Postmortem Changes / Q000378:metabolism*; D012151:Resuscitation; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D008077:Lipoproteins, LDL
Osobennosti izmeneniĭ nekotorykh pokazateleĭ obmena lipidov pri umiranii i posle ozhivleniia organizma.