title: Phosphorylation reactions in islets of Langerhans.
abstract: The possible significance of phosphorylation reaction in islets of Langerhans in relation to the secretion of insulin is discussed. The secretagogues, glucose and its metabolites, cAMP and Ca++ and their influences on protein-kinase activity are given particular attention. The data obtained by the authors, as well as by other groups, are in agreement that cAMP is a potent stimulator of protein kinase activity. Glucose and its metabolites influenced protein kinase activity in one instance. Ca++ in supraphysiological amounts inhibited protein phosphorylation. The links between phosphorylation reactions and insulin secretion are, at the present time, conjectural.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D005947:Glucose / Q000502:physiology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000201:enzymology*; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D010761:Phosphorus Radioisotopes; D011494:Protein Kinases / Q000502:physiology*; D051381:Rats
chemical_list: D007328:Insulin; D010761:Phosphorus Radioisotopes; D000242:Cyclic AMP; D011494:Protein Kinases; D010744:Phosphoric Monoester Hydrolases; D005947:Glucose