A review of marijuana in relation to stress-response mechanisms in the dental patient.
A comprehensive review of the established physiologic and metabolic effects of marijuana in relation to cardiovascular physiology and stress-response mechanisms has been presented. This information is related to the preoperative and postoperative treatment of the dental patient who smokes marijuana habitually. Marijuana is not a benign drug. Its vasoactive, cardiotropic, steroidogenic, and enhanced sympathoadrenal stress-response effects justify caution when administering atropine or epinephrine-containing products to the habitual user of marijuana. More clinical as well as laboratory research is needed to elucidate the speculation regarding a drug so frequently misused.
D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000313:Adrenal Medulla / Q000187:drug effects; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000494:pharmacology; D001519:Behavior / Q000187:drug effects; D002187:Cannabinol / Q000494:pharmacology; D002188:Cannabis; D002319:Cardiovascular System / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013312:Stress, Physiological / Q000139:chemically induced / Q000503:physiopathology*; D013610:Tachycardia / Q000139:chemically induced
D000305:Adrenal Cortex Hormones; D000779:Anesthetics, Local; D011943:Receptors, Adrenergic, beta; D002187:Cannabinol; D004837:Epinephrine