Swan mice: autoimmune mice without xenotropic type C virus production.
Swan mice are characterized by various autoimmune disorders and the Swan disease resembles that of (NZB X NZW)F1 hybrids. A virological study of these animals shows that: (a) they do not produce xenotropic type C viruses at a detectable level; (b) old Swan mice can produce ecotropic type C virus but at a low level; and (c) this virus production and the appearance of antinuclear antibodies are dissociated in some mice. These results do not support the role of xenotropic type C viruses in murine autoimmune pathology. A possible role of ecotropic type C viruses cannot be definitely excluded, but appears unlikely.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology / Q000382:microbiology*; D009500:Neutralization Tests; D012190:Retroviridae / Q000302:isolation & purification*; D014779:Virus Replication
D000974:Antibodies, Antinuclear