title: Factors affecting the interferon sensitivity of human cytomegalovirus.
abstract: Several factors affected the interferon sensitivity of human cytomegalovirus in human foreskin fibroblast cultures. An inoculum of infected cells was up to 300-fold less sensitive than a cell-free inoculum of equivalent input multiplicity. A 10-fold increase in the dose of infectious units of either type of inoculum was associated with a 10-fold or greater decrease in interferon sensitivity. Several aspects of the virus-cell interaction were examined and parameters indicative of cell infection were less inhibited by interferon than were those for virus replication.
mesh_terms: D000166:Acridines; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects* / Q000254:growth & development; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D007181:Inclusion Bodies, Viral / Q000187:drug effects; D007372:Interferons / Q000494:pharmacology*; D010948:Viral Plaque Assay
chemical_list: D000166:Acridines; D007372:Interferons