title: The use of early embryo aggregation derived mouse chimaeras. II. The study of disease processes.
abstract: Early embryo aggregation derived mouse chimeras have proven an extremely valuable tool to study development of disease processes. In this respect chimaeras prove a unique opportunity to study the interaction between cells genetically pre-destined to become diseased and a normal cell population within the same animal. In this situation chimaeras can be studied in view of possible 'correction' of the disease by the provision of a population of normal host cells and/or their products. Various host deficiency states including classic immune deficiency, potentially 'deficient' anemias and tumours have been studied--the subject of the review here.
mesh_terms: D000375:Aging; D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics; D000748:Anemia, Macrocytic / Q000235:genetics; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002449:Cell Aggregation; D002678:Chimera; D004622:Embryo, Mammalian / Q000166:cytology*; D005260:Female; D030342:Genetic Diseases, Inborn; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics; D008223:Lymphoma / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D051379:Mice; D009030:Mosaicism; D009136:Muscular Dystrophies / Q000235:genetics; D010954:Plasmacytoma / Q000235:genetics; D011247:Pregnancy; D012162:Retinal Degeneration / Q000235:genetics; D012729:Sex Chromosome Aberrations