title: Increased purine nucleotides in adenosine deaminase-deficient lymphocytes.
abstract: It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which were deficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.
mesh_terms: D000243:Adenosine Deaminase / Q000032:analysis / Q000172:deficiency*; D000244:Adenosine Diphosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000242:Cyclic AMP / Q000032:analysis / Q000096:biosynthesis; D006160:Guanosine Triphosphate / Q000032:analysis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000378:metabolism; D007223:Infant; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009700:Nucleoside Deaminases / Q000172:deficiency*; D011687:Purines / Q000032:analysis* / Q000096:biosynthesis; D011742:Pyrimidine Nucleotides / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D011687:Purines; D011742:Pyrimidine Nucleotides; D000244:Adenosine Diphosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase