[Regulatory interaction between the respiratory chain of mitochondria and the oxidative system of the endoplasmic reticulum].
A regulation mechanism of the interaction of microsomal oxidases and mitochondrial respiratory chain with oxidase substrates is suggested. Quantitative comparison of their affinity to microsomal oxidases and mitochondrial NADH-dehydrogenase is carried out. The interaction with both systems is found to be hydrophobic. It is found that microsomal oxidase substrates inhibit mitochondrial NADH-dehydrogenase at concentrations, which should completely fill the active site of cytochrome P-450. It is suggested that redistribution of reduced equivalents from mitochondria to microsomes and the acceleration of xenobiotic detoxication take place.
D001463:Barbiturates / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004579:Electron Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D008055:Lipids; D008861:Microsomes / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D012995:Solubility
D001463:Barbiturates; D008055:Lipids; D009243:NAD; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D009247:NADH, NADPH Oxidoreductases
Reguliatornye vzaimodeĭstviia dykhatel'noĭ tsepi mitokhondriĭ i okislitel'noĭ sistemy éndoplazmaticheskogo retikuluma.