The effects of amphiphilic compounds on phosphatidate metabolism.
Amphiphilic cations interact with phosphatidate and thereby change its physical properties. This interaction can redirect phospholipid metabolism. In the presence of Mg2+ amphiphilic cations inhibit the activity of phosphatidate phosphohydrolase and stimulate that of phosphatidate cytidylyltransferase. Increasing the concentration of Mg2+ further, or adding Ca2+ have similar effects, except that Ca2+ does not stimulate phosphatidate cytidylyltransferase activity. Amphiphilic anions reverse the effects caused by the amphiphilic cations. The implication of these results are discussed in relation to the pharmacological effects of amphiphilic cationic drugs.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003567:Cytidine Diphosphate Diglycerides; D005277:Fenfluramine / Q000494:pharmacology; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D013501:Surface-Active Agents / Q000494:pharmacology*
D003567:Cytidine Diphosphate Diglycerides; D010712:Phosphatidic Acids; D013501:Surface-Active Agents; D005277:Fenfluramine; D009713:Nucleotidyltransferases; C022348:phosphatidate cytidylyltransferase; D010744:Phosphoric Monoester Hydrolases; D008274:Magnesium; D002118:Calcium