Effects of follicle-stimulating hormone and luteinizing hormone on ovarian cyclic AMP and prostaglandin E in vivo in rats treated with indomethacin.
The role of prostaglandins in both FSH- and LH-mediated increases in ovarian cyclic AMP was examined in rats in vivo. Dose-related increases in ovarian cyclic AMP levels were observed 10 min after intravenous injection of FSH or LH. No changes in ovarian prostaglandin E (PGE) content were detected after injection of either gonadotrophin at doses which substantially enhanced cyclic AMP accumulation. Prior treatment of rats with indomethacin produced a greater than 50% decrease in ovarian PGE levels, but did not prevent the FSH- or LH-induced rise in ovarian cyclic AMP concentration. These in vivo experiments do not support the concept that PGE plays a role as an obligatory mediator for the gonadotrophin-induced rise in ovarian cyclic AMP levels.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats
D011458:Prostaglandins E; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D007213:Indomethacin