Electron microscopic search for endogenous type C virus production in organs of dexamethasone-treated C57BL/He and C57BL/6J mice.
Several organs of newborn or adult C57BL/He and C57BL/6J mice and of infant AKR mice were examined for type-C viral particles after treatment with dexamethasone, a corticosteroid hormone that stimulates C virus replication. In both C57BL strains C particles were consistently found in the exocrine pancreas of the newborns but in smaller number than that previously observed in the adults. No C particles were observed in the submaxillary salivary glands, bones or other organs examined in adult C57BL/He and C57BL/6J mice. In infant AKR mice, few C particles were observed in the exocrine pancreas or submaxillary salivary glands whereas they were found to be produced in large number by bone cells. The results suggest that in C57BL/He and C57BL/6J mice endogenous C particle production is continuous throughout life in the exocrine pancreas and is restricted to this tissue.
D000818:Animals; D000831:Animals, Newborn; D001842:Bone and Bones / Q000382:microbiology; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL / Q000382:microbiology*; D008854:Microscopy, Electron; D010179:Pancreas / Q000382:microbiology; D012190:Retroviridae / Q000302:isolation & purification*; D012469:Salivary Glands / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
D003907:Dexamethasone