Plasma membrane involvement in brown fat thermogenesis.
Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.
D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002462:Cell Membrane / Q000502:physiology; D006224:Cricetinae; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012964:Sodium / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D012964:Sodium; D011188:Potassium