Proteolysis of noncapsid protein 2 of type 3 poliovirus at the restrictive temperature: breakdown of noncapsid protein 2 correlates with loss of RNA synthesis.
Inhibition of RNA synthesis of the LH strain of type 3 poliovirus at the restrictive temperature occurs concurrently with the breakdown of noncapsid virus-specific peptide 2. This finding, along with other reported data (B.D. Korant, In Proteases and Biological Control, p. 621-644, 1975), suggests that noncapsid virus-specific peptide 2 is a component of the viral replicase.
D010452:Peptide Biosynthesis; D017955:Poliovirus / Q000378:metabolism*; D011487:Protein Conformation; D011498:Protein Precursors / Q000378:metabolism*; D012367:RNA, Viral / Q000096:biosynthesis*; D013696:Temperature; D014764:Viral Proteins / Q000096:biosynthesis / Q000378:metabolism*
D011498:Protein Precursors; D012367:RNA, Viral; D014764:Viral Proteins