Lipid droplets of interstitial medullary cells of intact rat kidney with two-kidney Goldblatt hypertension.
Electron microscopic studies have been carried out of the interstitial cells (IC) of the renal medulla in rats with Goldblatt hypertension. Analysis of variance has not revealed any differences in the number of droplets of "unclamped" kidney in the hypertensive rats as compared to the normotensive rats ("resistant" rats, rats with unilateral nephrectomy, and intact rats) at periods from 3 weeks to 1 year. The total volume of the droplets in the IC cytoplasm in hypertensive and intact animals also revealed no difference 3 weeks after the beginning of the experiment. A positive correlation has been found between the number of the droplets and their volume but the low value of the correlation coefficient (r = +0.28) suggests that the number of the droplets cannot be a reliable indicator of the variation of the amount (volume) of thelipid material contained in them. Since it is just the latter parameter that carries the most information for evaluating the content of the droplet material in the IC, preference should be given to calculating the droplet volume rather than counting the number of droplets. The IC in the animals of the experimental groups revealed hypertrophy and hyperlasia of the endoplasmic reticulum and the Golgi complex, which were especially marked at the earlier stages of the experiments.
D000818:Animals; D001699:Biometry; D006977:Hypertension, Renal / Q000378:metabolism / Q000473:pathology*; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007668:Kidney / Q000648:ultrastructure*; D007679:Kidney Medulla / Q000378:metabolism / Q000648:ultrastructure*; D008055:Lipids / Q000032:analysis*; D008297:Male; D008854:Microscopy, Electron; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
D008055:Lipids; D011453:Prostaglandins