title: An extended genetic recombination map for foot-and-mouth diseases virus.
abstract: The original foot-and-mouth diseases virus recombination map (Lake, Priston & Slade, 1975), which include 35 mutagen-induced ts mutants, has been extended both in detail and size by the mapping of a further 33 ts mutants (9 mutagen-induced and 24 spontaneous). The size increase from 0.57% to 3.27% maximum recombination fequency was principally due to the use of a new standardization technique for recombination fequencies but, in addition, the original map distance was increased by approx. 30% due to the mapping of new mutations. As in the original map, there was a marked concentration of mutations near the guanidine (gs) locus, i.e. 83% of the mutants had mutations in the third of the map adjacent to the gs locus.
mesh_terms: D005537:Aphthovirus / Q000187:drug effects; D002874:Chromosome Mapping; D004352:Drug Resistance, Microbial; D005472:Fluorouracil; D005796:Genes; D006146:Guanidines / Q000494:pharmacology; D006898:Hydroxylamines; D009153:Mutagens; D009154:Mutation; D011995:Recombination, Genetic
chemical_list: D006146:Guanidines; D006898:Hydroxylamines; D009153:Mutagens; D005472:Fluorouracil