[Simultaneous occurrence of primary hyperparathyroidism and pituitary Cushing's syndrome (author's transl)].
A case of primary hyperparathyroidism and coincidental Cushing's syndrome of hypothalamic-hypophyseal origin is reported. The hyperparathyroidism was based on an adenoma of the parathyroid glands and produced a severe hypercalcaemia (4.5 mmol/l) and calcinosis of kidneys and lungs. The Cushing's syndrome was caused by a hyperplasiogenic ACTH cell-adenoma of the pituitary which had induced a regulative hyperplasia of the ACTH-dependent zones of the adrenal cortex. The ultrastructure of the zona fasciculata and reticularis showed a conspicuous activation of the steroid hormone-producing organelles. The two endocrine diseases added together in skeleton, heart, duodenum, and pancreas. As a sign of hyperparathyroidism the osteoclastic absorption of the bone was strongly increased, whereas the bone formation was reduced due to the hypercortisolism. The pancreas showed a severe acute recurrence of chronic pancreatitis which was induced by a parathyrotoxic crisis. This was the immediate cause of death.
D000236:Adenoma / Q000150:complications; D000239:Adenoma, Acidophil / Q000150:complications; D002114:Calcinosis / Q000150:complications; D003480:Cushing Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications; D008171:Lung Diseases / Q000150:complications; D008854:Microscopy, Electron; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology
Zur Morphologie einer Syntropie von primärem Hyperparathyreoidismus und hypophysärem Cushing-Syndrom