The potency ratio of galanthamine and neostigmine on the reversal of the tubocurarine block in the isolated rat diaphragm.
The potency ratio of galanthamine and neostigmine was studied on the rat phrenic nerve-diaphragm preparation. This ratio appeared to be about 18 on a weight base. The potency ratio in man in vivo, is about 20. Hence we concluded that this potency ratio might mainly be due to the difference in potency on the neuromuscular transmission and not to kinetic differences.
D000818:Animals; D003964:Diaphragm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005702:Galantamine / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D005702:Galantamine; D009388:Neostigmine; D014403:Tubocurarine