title: Effect of vitamin D3 and 1,25-dihydroxyvitamin D3 on intestinal transport of phosphate.
abstract: Dietary variations (low calcium, low calcium, low phosphorus, or high strontium) change phosphate transport by the jejunum according to their respective ability to increase or block the synthesis of 1,25-dihydroxyvitamin D3, suggesting that the action of this active sterol underlies the response of intestinal phosphate absorption to vitamin D. 1,25-(OH)2D3 stimulates the active entry of Pi at the mucosal border by its action on protein synthesis. It is attractive to speculate that 1,25-(OH)2D3 might induce the synthesis of a "phosphate carrier" protein in the plasma membrane. The interpretation that the enhancement of the maximal velocity of the "phosphate pump" by vitamin D is due to the creation of new pump sites would be consistent with this hypothesis.
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D004032:Diet; D004100:Dihydroxycholecalciferols / Q000096:biosynthesis / Q000494:pharmacology*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D013324:Strontium / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000378:metabolism*
chemical_list: D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010710:Phosphates; D002762:Cholecalciferol; D003513:Cycloheximide; D002118:Calcium; D013324:Strontium