title: Lysosomal enzyme secretion in rat ventral prostate. Secretagogue action of testosterone and dibutyryl cyclic AMP.
abstract: Rat ventral prostate slices, when incubated in vitro, secrete protein, lysosomal enzymes and newly phosphorylated components in a time- and temperature-dependent manner. Testosterone and dibutyryl cyclic AMP immediately stimulate secretion and 32Pi incorporation. Acid phosphatase and beta-N-acetylhexosaminidase are secreted as acidic isoenzymes presumably contained within primary lysosomes.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D003994:Bucladesine / Q000494:pharmacology*; D006596:Hexosaminidases / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D007700:Kinetics; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010766:Phosphorylation; D011467:Prostate / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D003994:Bucladesine; D006867:Hydrolases; D000135:Acid Phosphatase; D001192:Arylsulfatases; D006596:Hexosaminidases