[Pathogenesis of creatinuria and aminoaciduria in neuromuscular diseases].
By introducing inhibitors of phosphodiestherase and adenylacyclase the authors studied the role of cyclic AMP in the pathogenesis of creatinuria and aminoaciduria in neuro-muscular diseases. It was demonstrated that in patients with Duchenne myopathy creatinuria and aminoaciduria were possibly due to a deop of nucleotide level in the muscles. And on the contrary in cases of Erb's and Landouzy-Dejerine myopathy the changes of nitrogen metabolism are due to an increased content of cyclic AMP. These data may be used for differential diagnosis of myopathy.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000652:urine*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D002110:Caffeine; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000652:urine*; D000242:Cyclic AMP / Q000378:metabolism*; D005152:Facial Muscles; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000378:metabolism; D009136:Muscular Dystrophies / Q000235:genetics / Q000378:metabolism; D009468:Neuromuscular Diseases / Q000378:metabolism* / Q000652:urine; D011433:Propranolol; D012782:Shoulder; D013577:Syndrome
D000596:Amino Acids; D002110:Caffeine; D011433:Propranolol; D000242:Cyclic AMP; D003401:Creatine
K patogenezu kreatinurii i aminoatsidurii pri nervno-myshechnykh zabolevaniiakh.