[Thermal sensitivity of specific transplantation antigens of the tumor-cell membrane].
Study of temperature-sensitivity of the tumour specific transplantation antigen (TSTA) on the cell membrane of SV40-induced tumours and spontaneous hepatoma of inbred Syrian hamsters, as well as in the monkey cells infected in vitro with SV40 virus (ts-mutant) demonstrated high thermolability of TSTA. Heating such cells at 56 degrees C for 30-60 min led to complete loss of their immunogenic activity. Moreover, in the animals immunized with heated tumour cells the test-tumour cell growth was regularly enhanced.
D000818:Animals; D000951:Antigens, Neoplasm; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002462:Cell Membrane / Q000276:immunology; D006224:Cricetinae; D000882:Haplorhini; D006649:Histocompatibility Antigens; D006358:Hot Temperature; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000473:pathology*; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000473:pathology*; D013539:Simian virus 40
D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens
Termochuvstvitel'nost' spetsificheskikh transplantatsionnykh antigenov kletochnoĭ membrany opukholevykh kletok.