title: Respective importance of different electrophysiological parameters in alcoholic neuropathy.
abstract: An electrophysiological study of alcoholic and normal subjects is presented. The aim was to evaluate the respective importance of the various parameters. The subjects were divided into 4 groups: (I) normal subjects; (II) chronic alcoholics without clinical evidence of neuropathy; (III) chronic alcoholics with sensory symptoms; (IV) chronic alcoholics with both motor and sensory symptoms. The electrophysiological parameters tested were: conduction velocity (CV) in Ia sensory fibres, motor fibres, and cutaneous sensory fibres of the popliteal nerve, CV in the sural nerve, amplitude of the cutaneous sensory action potentials (SAP) in the sural and popliteal nerves, H reflex and M response of the soleus muscle, and electromyograms from the extensor digitorum brevis muscle. In the 3 groups of alcoholics, the electrophysiological findings were more abnormal than the clinical symptoms could have predicted. The more sensitive parameters were: (1) CV in the Ia sensory fibres of the popliteal nerve, which is slowed very early (in Group II) and (2) measurement of the amplitude of sural and popliteal SAP's which are also reduced early (in Group II). The nature of the mechanisms involved are discussed.
mesh_terms: D000200:Action Potentials; D000328:Adult; D000437:Alcoholism / Q000150:complications*; D004576:Electromyography; D006801:Humans; D008875:Middle Aged; D009046:Motor Neurons; D009132:Muscles / Q000503:physiopathology; D009431:Neural Conduction; D009475:Neurons, Afferent; D010525:Peripheral Nerves / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D011930:Reaction Time; D012023:Reflex, Monosynaptic; D013497:Sural Nerve / Q000503:physiopathology; D013997:Time Factors