title: A low molecular weight substance obtained from serum which has luteinizing hormone like activity ("mini LH").
abstract: A low molecular weight substance of 1000-2000 daltons has been isolated in dialysates of normal human serum which, on testing in a radio-immunoassay, a radioligand receptorassay and an in-vitro bioassay exhibited LH activity comparable to the range of LH activity found in normal serum. The substance was heat labile. Its reactivity in a RIA suggests peptide nature. No "mini LH" activity could be derived from LH-free serum samples of hypophysectomized patients.
mesh_terms: D001681:Biological Assay; D003956:Dialysis; D006358:Hot Temperature; D006801:Humans; D007526:Isoelectric Point; D007986:Luteinizing Hormone / Q000032:analysis / Q000097:blood; D008297:Male; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis; D011863:Radioimmunoassay; D011956:Receptors, Cell Surface
chemical_list: D010455:Peptides; D011956:Receptors, Cell Surface; D007986:Luteinizing Hormone