[Neurochemical mechanisms of the action of tricyclic antidepressants of the imipramine group].
The main role in determination of the pharmacologic effects of the imipramine groups antidepressants is given to their influence on neurotransmitters metabolism in synapses, the activity of enzymic systems regulating the transport of ions, as well as on the system of cyclic AMP metabolism. Interaction of tricyclic antidepressants with membrane and, as the result, distrubance in reuptake of transmitters (epinephrine and 5-hydroxytryptamine) in neurons is supposed to be one of the mechanisms of synaptic transmission regulation. The possible role in inhibition of biological amines deamination, in particular of phenylethylamine, in antidepressive effect of tricyclic antidepressants is discussed. It is supposed that the thymoanaleptic effects of the imipramine group antidepressants are due to activation of central serotoninergic processes, and their psychoanaleptic effect due to activation of the adrenergic system. Inhibition of the Na+, K+-ATPase activity quilizing effect of tricyclic antidepressants.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000588:Amines / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009448:Neurochemistry; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
D000588:Amines; D000929:Antidepressive Agents, Tricyclic; D001679:Biogenic Amines; D002395:Catecholamines; D012701:Serotonin; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D007099:Imipramine
Neĭrokhimicheskie mekhanizmy deĭstviia tritsiklicheskikh antidepressantov gruppy imipramina