Radiochemical purity of various 99mTc-labelled bone-scanning agents.
The radiochemical purity of preparations for 99mTc-bone-scanning was tested using thin-layer chromatography and electrophoresis. The investigation included ten commercial kits, comprising four types of phosphorus compounds, i.e. sodium polyphosphate, sodium pyrophosphate, disodium  diphosphonate, and sodium monofluorophosphate. Out-spoken differences in the content of free pertechnetate were found between the different kits. The contents in preparations from the same kit were fairly constant, but in some cases a change could be referred to the age of the 99mTc-generator or the time of analysis. No significant difference was found between preparations made from eluate with and without oxidizer. A 99mTc-tin-colloid was sporadically present in the preparations.
D001847:Bone Diseases / Q000175:diagnosis; D011756:Diphosphates; D004164:Diphosphonates; D005069:Evaluation Studies as Topic; D010710:Phosphates; D011877:Radionuclide Imaging / Q000592:standards*; D013667:Technetium / Q000032:analysis
D011756:Diphosphates; D004164:Diphosphonates; D010710:Phosphates; D013667:Technetium