Effect of interferon on antibody formation.
Virus-type interferon is capable of suppressing the antibody response both in vivo and in vitro. Interferon induced by antigen or mitogen (immune interferon) primarily in T lymphocytes also appears capable of suppressing the antibody response. Cyclic AMP has a regulatory effect on the induction of both virus-type and immune interferon. The immunosuppressive effects of virus-type and immune interferon may differ at the cellular or subcellular level.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000276:immunology; D003994:Bucladesine / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014780:Viruses / Q000276:immunology
D007073:Immunoglobulin E; D003994:Bucladesine; D007372:Interferons