The effects of anticholinergics on the urinary bladder mechanism.
A summary is given of the physiological conditions concerned with collection and expulsion of urine from the bladder. The role of afferent and efferent nerve activity from and to the urinary bladder and urethra is discussed. When studying the effects of anticholinergics on the urinary bladder in animals an in situ model described here seems to be the most valid for conditions in man. This method involves recording of the intravesical pressure in conscious rabbits stimultaneously with a bladder infusion. An assessment is made of the evidence for a purinergic transmission in the urinary bladder.
D000255:Adenosine Triphosphate / Q000494:pharmacology / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002490:Central Nervous System / Q000502:physiology; D004525:Efferent Pathways / Q000502:physiology; D006168:Guinea Pigs; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D011312:Pressure; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D001743:Urinary Bladder / Q000294:innervation*; D014554:Urination / Q000187:drug effects
D010276:Parasympatholytics; D011941:Receptors, Adrenergic; D000255:Adenosine Triphosphate