title: Gonadotropin output in congenital adrenal hyperplasia before and after adrenal suppression.
abstract: Basal release of gonadotropin and the response to an infusion of 100 mug of synthetic luteinizing hormone releasing hormone (LRH) were studied in a teenage girl with congenital adrenal hyperplasia (CAH). The initial study was done during a period of poor adrenal suppression, and second study was done after adequate adrenal suppression was achieved. To assess adrenal function, circulating levels of adrenal steroid hormones were evaluated continuously over a 24 h period. During the period increased production of adrenal androgens, the pattern of gonadotropin release was that of a prepubertal child. After 3 months of adrenal suppression the pattern of gonadotropin secretion was similar to that of a normal girl in mid-puberty. This demonstrates the rapid change from prepubertal to pubertal gonadotropin dynamics in a teenage patient following adequate suppression of androgens from the adrenal.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000311:Adrenal Glands / Q000503:physiopathology*; D000308:Adrenocortical Hyperfunction / Q000188:drug therapy / Q000503:physiopathology*; D000365:Age Determination by Skeleton; D000735:Androstenedione / Q000097:blood; D002940:Circadian Rhythm; D003348:Cortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood
chemical_list: D015068:17-Ketosteroids; D006908:Hydroxyprogesterones; D007987:Gonadotropin-Releasing Hormone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003348:Cortisone