Reductive dechlorination of DDT by haem proteins.
DDT1 is converted to DDD by reduced myoglobin (rapidly), cytochrome c oxidase, and a haem-containing undecapeptide derived from cytochrome c. Cytochrome c itself is inactive. This demonstrates that an accessible haem site is necessary for the reaction. Spectrophotometric evidence is presented for an interaction between DDT and the undecapeptide. These results cast light on one of the biological pathways for the breakdown of DDT.
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003574:Cytochrome c Group; D003634:DDT / Q000032:analysis; D003576:Electron Transport Complex IV; D006420:Hemeproteins; D009211:Myoglobin; D010084:Oxidation-Reduction; D013053:Spectrophotometry; D013997:Time Factors
D003574:Cytochrome c Group; D006420:Hemeproteins; D009211:Myoglobin; D003634:DDT; D003576:Electron Transport Complex IV