On the relationship between inflammation and altered cAMP metabolism in lungs of B pertussis-vaccinated mice.
Bordetella pertussis-vaccinated mice were examined for evidence of inflammation. Using polymorphonuclear leukocyte and fluid accumulation as markers, inflammation was evidenced in the lungs and to a lesser extent in the livers of such mice. Both heart and kidney showed no evidence of inflammation. Development of the inflammatory lesion followed a time course similar to that previously reported for increased sensitivity to histamine-mediated cAMP accumulation. This close parrallelism between inflammation and altered cAMP metabolism supports the hypothesis that the increased  cAMP accumulation might be related to a feedback mechanism regulating inflammatory mediator release.
D000818:Animals; D001428:Bacterial Vaccines / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000276:immunology*; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D007249:Inflammation / Q000209:etiology*; D007958:Leukocyte Count; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D009504:Neutrophils; D009929:Organ Size; D011014:Pneumonia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D011654:Pulmonary Edema / Q000209:etiology
D001428:Bacterial Vaccines; D000242:Cyclic AMP