[Effect of benz(a)pyrene on a monolayer culture of normal and malignant mouse liver cells].
Both the cells of monolayer culture of mouse embryonic liver and that of highly malignant hepatoma 22A transplanted for 20 years actively metabolized the carcinogenic hydrocarbon benz(a)pyrene and were highly sensitive to iits toxic action. Since hepatic tissue was resistant in vivo to carcinogenic carbohydrates it is suggested that the resistance depended on factors acting at the organ or the organism but not as the cellular level. The mechanism of retention of hepatoma 22A sensitivity to the toxic action of benz(a)pyrene is also discussed.
D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D008099:Liver; D008113:Liver Neoplasms; D051379:Mice; D008940:Mitotic Index; D009374:Neoplasms, Experimental; D013997:Time Factors
D001580:Benzopyrenes
Vliianie benz(a)pirena na monosloĭnuiu kul'turu normal'nykh i zlokachestvennykh kletok pecheni myshi.