[Effect of heparin on the activity of liver microsome oxidative enzyme systems in healthy rats and rats with experimental glomerulonephritis].
In experiments on mongrel rats it was found that heparin in doses of 2, 5, and 10 mg/kg had an inducing effect on the oxidative systems of hepatic microsomes: hexenal test period was shortened, cytochrome P450 content increased, relative liver weight rose; the activity of histochemically-detectable NAD-enzymes of hepatocytes became greater. Heparin was capable of considerable (2-3-fold) stimulation of antitoxic activity of the liver reduced in experimental glomerulonephritis. The effect of heparin on the antitoxic function of the liver did not correlate with its effect, on the blood coagulation system.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology; D006591:Hexobarbital / Q000378:metabolism; D006651:Histocytochemistry; D008099:Liver / Q000648:ultrastructure; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D009243:NAD; D006493:Heparin; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D013385:Succinate Dehydrogenase
Vliianie geparina na aktivnost' okislitel'nykh fermentnykh sistem mikrosom pecheni u zdorovykh krys i krys s éksperimental'nym gloverulonefritom.