The effects of cytochalasin and colchicine on interferon production.
The present study was undertaken to investigate the mechanism of interferon production by mouse spleen cells co-cultivated with BHK-HVJ cells, i.e. baby hamster kidney cells persistently infected with the HVJ (or Sendai) strain of para-influenza I virus. Cytochalasin B appears to inhibit an early stage in the process and colchicine a relatively late stage. It is suggested that microfilaments and microtubules may play in important role at an initial stage of interferon production in this system.
D000818:Animals; D002460:Cell Line; D003078:Colchicine / Q000494:pharmacology*; D006224:Cricetinae; D046508:Culture Techniques; D003571:Cytochalasin B / Q000494:pharmacology; D003572:Cytochalasins / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D010222:Parainfluenza Virus 1, Human; D013154:Spleen
D003572:Cytochalasins; D003571:Cytochalasin B; D007372:Interferons; D003078:Colchicine