Incomplete anaerobiosis as a cause of metronidazole 'resistance'.
Clostridium welchii, used as a control, was found to grow well in a microaerophilic jar used for campylobacters but appeared resistant to a metronidazole disc although the campylobacter was sensitive. Minimum inhibitory concentrations for six strains of Cl. welchii were up to 64-fold higher in these conditions than when grown anaerobically. Zones of inhibition with both Cl. welchii and Bacteroides fragilis varied with the amount of air admitted to anaerobic jars.
D000693:Anaerobiosis; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000378:metabolism; D002167:Campylobacter / Q000187:drug effects; D003016:Clostridium perfringens / Q000187:drug effects* / Q000378:metabolism; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D008795:Metronidazole