[Transforming action of the total RNA preparations isolated from Rous virus-induced sarcomas].
The authors compared the effect of RNA substances isolated from chick sarcomas producing Rous virus and hamster sarcomas not producing the virus. In both species of animals the tumors were induced by the same Rous virus strain (Carr-Zilber). The treatment of embryonal cells cultures both of the chick and hamster with RNA preparations resulted in the morphological transformation. The action of RNA-s would reduce considerably or eliminated totally the effect, while DNA-s failed to influence the activity of the preparations under study. Embryonal cells culture in hamsters proved to be more sensitive to RNA action than chick cells.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D006224:Cricetinae; D003851:Deoxyribonucleases / Q000494:pharmacology; D009368:Neoplasm Transplantation; D012334:RNA, Neoplasm / Q000494:pharmacology*; D012260:Ribonucleases / Q000494:pharmacology; D001357:Sarcoma, Avian / Q000378:metabolism*; D013997:Time Factors
D012334:RNA, Neoplasm; D003851:Deoxyribonucleases; D012260:Ribonucleases
O transformiruiushchem deĭstvii preparatov summarnoĭ RNK, vydelennykh iz sarkom indutsirovannykh virusom Rausa.