[Tumorigenicity of TTT dissolved in DMSO (author's transl)].
In short-term experiments TTT (trinitroso-trimethylene-triamine) dissolved in DMSO (dimethylsulfoxide) caused, when orally or intraperitoneally applied, a significant enhancement of the mitotic rate in the adrenal cortex. By long-term studies the carcinogenic action of TTT in DMSO was demonstrated. In female Wistar rats a 100% liver tumor yield was observed following chronic application. After 362 days of treatment cholangiomas had developed, hepatomas and liver carcinomas occurred after 470 days of administration of TTT dissolved in DMSO.
D002759:Adenoma, Bile Duct / Q000139:chemically induced* / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D004357:Drug Synergism; D005260:Female; D007274:Injections, Intraperitoneal; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines; D051381:Rats; D013997:Time Factors
D002273:Carcinogens; D009602:Nitrosamines; D004121:Dimethyl Sulfoxide
Tumorinduzierende Wirkung von Trinitroso-trimethylen-triamin in Verbindung mit Dimethylsulfoxid