Effect of antitonin on blood pressure in the one-kidney hypertensive rat.
1. The tonin concentration of saliva and submaxillary glands was studied in one-clip hypertensive rats with or without the contralateral kidney. 2. Salivary tonin concentration was elevated in one-kidney hypertensive rats, but not in one-kidney normotensive or two-kidney, one-clip hypertensive rats. In contrast, an elevated submaxillary gland tonin concentration was found only in uninephrectomized animals, whether normotensive or hypertensive. 3. A single intravenous administration of rabbit tonin antiserum into one-kidney hypertensive rats restored blood pressure to normal in seven out of ten animals. There was little change in blood pressure in two-kidney, one-clip hypertensive, uninephrectomized or sham-operated rats. 4. These findings suggest a connection between the physiology of the kidney and of the submaxillary gland in the rat, and indicate that tonin may play a significant role in maintaining high blood pressure in one-kidney hypertensive aniamls.
D000818:Animals; D001794:Blood Pressure; D004306:Dose-Response Relationship, Immunologic; D006977:Hypertension, Renal / Q000201:enzymology* / Q000276:immunology; D007106:Immune Sera; D008297:Male; D009392:Nephrectomy; D007703:Peptidyl-Dipeptidase A / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D012463:Saliva / Q000201:enzymology; D013363:Submandibular Gland / Q000201:enzymology
D007106:Immune Sera; D007703:Peptidyl-Dipeptidase A