Metabolic effects of some antibilharzial drugs: inhibition of NAD-linked substrate oxidation in rat liver by bilharcid.
BILHARCID inhibited malate and pyruvate oxidation. The degree of inhibition reached 50% when the concentration of Bilharcid was 10(-3) M. The mechanisms of the inhibitory action of the drug are discussed with reference to the effects of both adenine and pyridine nucleotides on the activity of the oxidoreductase enzymes.
D000818:Animals; D000965:Antimony / Q000378:metabolism*; D002951:Citrates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008293:Malates / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D012556:Schistosomicides / Q000378:metabolism*; D013379:Substrate Specificity
D002951:Citrates; D008293:Malates; D011773:Pyruvates; D012556:Schistosomicides; D009243:NAD; D000965:Antimony; D010088:Oxidoreductases