[Norepinephrine interference in adrenal hormone balance related to blood calcium effects of PTH (author's transl)].
Decreased hypercalcemic effects of PTH are observed after medulloadrenalectomy, (table I), metoprione (table II) or cortisone (table IV) treatments in guinea pigs. 2. Norepinephrine restores the blood calcium effects of PTH in these cases but epinephrine is inactive. 3. Immediate activation of kidney adenylate cyclase by PTH (increased urinary AMPc) is also reduced in medulloadrenalectomised, cortisone or metopirone treated guinea pigs (table V). But in this test, norepinephrine reduces the effect of PTH (fig. 1).
D000311:Adrenal Glands / Q000502:physiology*; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000097:blood*; D003348:Cortisone / Q000494:pharmacology; D000242:Cyclic AMP / Q000652:urine; D004837:Epinephrine / Q000494:pharmacology / Q000652:urine; D006168:Guinea Pigs; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology* / Q000652:urine; D010281:Parathyroid Hormone / Q000494:pharmacology*
D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002118:Calcium; D003348:Cortisone; D009638:Norepinephrine; D004837:Epinephrine; D008797:Metyrapone
Rôle de la noradrénaline dans l'équilibre hormonal surrénalien intervenant sur l'activité de l'hormone parathyroïdienne.