Agonist effects of beta-phenethylamines on the noradrenergic cyclic adenosine 3',5'-monophosphate generating system in rat limbic forebrain. Stereoisomers of p-hydroxynorephedrine.
Significant agonist activity for the specific noradrenergic cyclic adenosine 3',5'-monophosphate (cAMP) generating system in rat limbic forebrain requires a beta-3,4-dihydroxyphenethylamine with a beta-hydroxyl group in the R configuration. Thus, neither of the enantiomers of p-hydroxynorephedrine nor of p-hydroxynorpseudoephedrine mimics the agonist activity of (R)-norepinephrine. It has yet to be established whether or not one of the p-hydroxynorephedrines exhibits antagonist activity in this same system.
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008968:Molecular Conformation; D010665:Phenylpropanolamine / Q000031:analogs & derivatives*; D051381:Rats; D013237:Stereoisomerism; D010137:p-Hydroxynorephedrine / Q000138:chemical synthesis* / Q000494:pharmacology
D010665:Phenylpropanolamine; D010137:p-Hydroxynorephedrine; D000242:Cyclic AMP