Neuroheptapeptide influence on attention and memory in man.
Twenty normal, male volunteers were administered a subcutaneous injection of either ACTH/MSH 4-10 or diluent and two weeks later received the alternate injection in a complete crossover, double-blind design with order balanced. Subjects were given a battery of psychological tests, including a continuous performance task (CPT), following each injection. Visual evoked responses were recorded during the CPT. Resting, eyes-closed EEGs were also obtained. ACTH/MSH 4-10 improved attention and in so doing improved visual-motor learning and visual, but not verbal, memory, EEG data were consistant with activation of the diffuse thalamic projection system.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000328:Adult; D001007:Anxiety; D001288:Attention / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials; D006801:Humans; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects*; D009778:Occipital Lobe / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology; D013647:Task Performance and Analysis; D014785:Vision, Ocular
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones