The effects of nortriptyline and mesoridazine on neurons and glia in vitro.
The ultrastructural changes produced by Mesoridazine and Nortriptyline in neurons and glia in vitro are reported. Concentrically laminated bodies (CLB) and increased numbers of dense bodies were produced by exposure to these drugs. The number and complexity of the CLB increased with increased dose and longer time in vitro and their formation appeared to be reversible.
D000818:Animals; D002478:Cells, Cultured; D002479:Inclusion Bodies / Q000648:ultrastructure; D008653:Mesoridazine / Q000494:pharmacology*; D051379:Mice; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D009457:Neuroglia / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D009661:Nortriptyline / Q000494:pharmacology*
D008653:Mesoridazine; D009661:Nortriptyline