Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin.
Alrestatin at 25-1 X 10(-4) M inhibited the accumulation of cyclic AMP induced by prostaglandin E2, but not theophylline, in the rat anterior pituitary in vitro. Somatostatin, at lower concentrations, inhibited both; maximal inhibition of the prostaglandin effect was greater with alrestatin. As cyclic AMP is considered to be a mediator in induced-hormonal release, it appears from the present findings that alrestatin may be of potential use in altering hormonal release.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D007546:Isoquinolines / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D007546:Isoquinolines; D011458:Prostaglandins E; D013004:Somatostatin; C016212:alrestatin; D013806:Theophylline; D000242:Cyclic AMP