interactions of ionizing radiation, nitrosamines, sulfonoxyalkanes and antioxidants as they affect carcinogenesis and survival in mice.
Butylated hydroxytoluene (BHT), pretreatment of 8-wk-old BALB/c mice for 28 days protected against 30-day lethality by X-rays, diethylnitrosamine (DEN), dimethylnitrosamine (DMN) and ethyl methanesulfonate (EMS) but not against methyl methanesulfonate (MMS). In X-ray survivors, neither mean survival nor leukemia incidences were affected by BHT. However, BHT (lifetime), given alone or with DEN (300 MG/KG BW in H2O) or 250 R X-rays, increased irradiated survivors at 18 months but not leukemia or tumor incidences. BHT + DEN treated females had increased survival and a decreased frequency of forestomach squamous carcinomas compared with DEN alone; no differences were seen in males or in pulmonary adenomas. In X-ray + DEN treated females, effect upon survival was additive, but the specific diseases causing this effect were not identified.
D000818:Animals; D000975:Antioxidants; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002273:Carcinogens; D003043:Cocarcinogenesis; D003408:Cresols / Q000633:toxicity*; D004052:Diethylnitrosamine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004347:Drug Interactions; D005260:Female; D007928:Lethal Dose 50; D007938:Leukemia / Q000209:etiology; D008297:Male; D008698:Mesylates / Q000037:antagonists & inhibitors; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000209:etiology*; D009602:Nitrosamines / Q000633:toxicity*; D014965:X-Rays
D000975:Antioxidants; D002273:Carcinogens; D003408:Cresols; D008698:Mesylates; D009602:Nitrosamines; D002084:Butylated Hydroxytoluene; D004052:Diethylnitrosamine