[New aspects of catecholamin-receptor interactions. Pathophysiological and clinical implications (author's transl)].
The molecular aspects of catecholamine-receptor interactions are reviewed with respect to their clinical implications. Beta- and in some tissues alpha-adrenergic receptors are coupled to the membrane-bound adenylate cyclase. The adrenergic receptor sites are distinct membrane constituents. Their number and the ratio alpha-to beta-receptor site depend on the plasma concentration of catecholamines and are affected by diet and endocrinological factors. Recent clinical studies suggest that long-term treatment with beta-adrenergic agonists may induces desensitization of target tissues due to changes in the adrenergic receptor moieties.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001249:Asthma / Q000378:metabolism / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D006801:Humans; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism / Q000503:physiopathology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism / Q000503:physiopathology
D002395:Catecholamines; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000262:Adenylyl Cyclases
Neue Aspekte der Katecholamin-Rezeptor Wechselwirkung. Ihre Bedeutung in Pathophysiologie und Klinik.