Thymosin-induced human serum factor increasing cyclic AMP.
Thymosin has virtually no in vitro effect on cyclic AMP levels in thymocytes and seems not to react with either the beta-adrenergic receptor or with the putative human serum thymic factor (SF) receptor. However, when thymosin is injected into patients lacking SF activity, it induces the appearance of a serum factor which increases cellular cyclic AMP levels in thymocytes in vitro. This factor appears to act on a membrane site distinct from the beta-adrenergic receptors.
D000818:Animals; D002675:Child, Preschool; D000242:Cyclic AMP / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D013947:Thymosin / Q000494:pharmacology*; D013951:Thymus Hormones / Q000097:blood* / Q000494:pharmacology*; D013997:Time Factors
D013951:Thymus Hormones; D013947:Thymosin; D000242:Cyclic AMP; D007545:Isoproterenol