Comparison of the humoral and cellular immune response after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizations.
Antibody and cell-mediated immune responses were measured in rabbits immunized with live, UV inactivated herpes simplex virus or with a subunit vaccine containing envelope proteins. All the types of immunization procedures induced the production of antibody as well as a specific cellular immunity. Furthermore, the subunit vaccine was as effective as the immunization with live or UV inactivated virus to prevent death upon challenge with live HSV. Live HSV induced a transient unresponsiveness of both B and T cells to in vitro stimulation with various mitogens.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000187:drug effects; D003168:Complement Fixation Tests; D006561:Herpes Simplex / Q000517:prevention & control; D008213:Lymphocyte Activation; D008934:Mitogens; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects; D014466:Ultraviolet Rays; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines
D008934:Mitogens; D014764:Viral Proteins; D014765:Viral Vaccines