title: Hormone-induced dispersion or aggregation of carotenoid-containing smooth endoplasmic reticulum in cultured xanthophores from the goldfish, Carrassius auratus L.
abstract: A novel organelle movement is described in goldfish xanthophores. Smooth endoplasmic reticulum, containing carotenoids pigments, undergo MSH or c-AMP-induced dispersion. This dispersion is independent of RNA and protein synthesis, not modulated by c-GMP and inhibited by cytochalasin B but only at the relatively high concentration of 10 mug/ml. Epinephrine induces aggregation, a process that is inhibited by colchicine. These results suggest, but do not prove, the involvement of microfilaments in dispersion and microtubules in the aggregation of carotenoid-containing endoplasmic reticulum.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D003994:Bucladesine / Q000494:pharmacology*; D002338:Carotenoids / Q000378:metabolism*; D003078:Colchicine / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D006054:Goldfish; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D010860:Pigments, Biological / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects; D012867:Skin / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D010860:Pigments, Biological; D002338:Carotenoids; D003571:Cytochalasin B; D003994:Bucladesine; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D000242:Cyclic AMP; D003078:Colchicine; D004837:Epinephrine