[Effect of 5-fluorouracil and thiophosphamide on the activity and fractional content of phosphatases of Zajdela hepatoma].
The administration of different types of antitumor drugs is found to lead to a decrease in total activity of phosphatases in mitochondrial, lysosomal and microsomal fraction of Zajdela hepatoma cells, the free activity being enhanced. The isoenzyme pattern of phosphatases in soluble fraction is influenced too. The results suggest that different antitumor drugs cause a uniform response in tumor cells, manifested in disorders in the protein synthesizing system and membranes of subcellular particles involved.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D005472:Fluorouracil / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D008247:Lysosomes / Q000201:enzymology; D008861:Microsomes / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051381:Rats; D013852:Thiotepa / Q000627:therapeutic use*
D013852:Thiotepa; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D005472:Fluorouracil
Deĭstvie 5-ftoruratsila i tiofosfamida na aktivnost' i fraktsionnyĭ sostav fosfataz gepatomy Zaĭdela.