Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine.
N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.
D002759:Adenoma, Bile Duct / Q000139:chemically induced*; D000818:Animals; D001650:Bile Duct Neoplasms / Q000139:chemically induced*; D006224:Cricetinae; D006168:Guinea Pigs; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000633:toxicity*; D009928:Organ Specificity; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D013045:Species Specificity
D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine