Prostaglandin E1 inhibitis platelet aggregation by a pathway independent of adenosine 3',5'-monophosphate.
Aggregation of human blood platelets induced by adenosine diphosphate or 1-epinephrine was inhibited when the platelets were suspended in plasma which had been previously exposed to an insolubilized omega-aminohexylagarose derivative of prostaglandin E1. This decrease of platelet aggregation was not accompanied by a change in the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in platelets. The results demonstrate the existence of an alternative pathway independent of cyclic AMP for the inhibition of platelet aggregation by plasma.
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000242:Cyclic AMP / Q000097:blood*; D004837:Epinephrine / Q000037:antagonists & inhibitors; D006801:Humans; D010949:Plasma / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D012685:Sepharose / Q000031:analogs & derivatives; D012995:Solubility
D011459:Prostaglandins E, Synthetic; D000244:Adenosine Diphosphate; D012685:Sepharose; D000242:Cyclic AMP; D004837:Epinephrine