title: Reversion of temperature sensitive transformation mutants of Rous sarcoma virus and its effect on the expression of tumour specific surface antigen.
abstract: Rous sarcoma virus (RSV) mutants, which bear temperature sensitive (ts) defects in both the maintenance of cell transformation and the expression of tumour specific cell surface antigen(s) (TSSA), have yielded a number of revertants. In seven revertants studied, the acquisition of wild type transforming capacities is always accompanied by a wild type TSSA expression. This strongly indicates that transformation and TSSA expression in RSV are affected by the same mutation.
mesh_terms: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000956:Antigens, Viral; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D002472:Cell Transformation, Viral; D005814:Genes, Viral; D009154:Mutation; D013696:Temperature
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000956:Antigens, Viral