In vitro antiviral efficacy of ribavirin against feline calicivirus, feline viral rhinotracheitis virus, and canine parainfluenza virus.
Ribavirin had marked in vitro activity against feline calcivirus, strain 255, and canine parainfluenza virus, but showed only slight antiviral effect on feline viral rhinotracheitis virus. Antiviral activity was manifested by partial to complete suppression of viral cytopathic effect and of viral replication, depending on concentration of ribavirin in the culture medium and dosage of viral inoculum. Concentrations of ribavirin as small as 3.2 microgram/ml and 1.0 microgram/ml showed some activity against feline calcivirus and canine parainfluenza virus, respectively.
D000818:Animals; D002139:Caliciviridae / Q000187:drug effects* / Q000254:growth & development; D002415:Cats / Q000382:microbiology; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004285:Dogs / Q000382:microbiology; D006564:Herpesviridae / Q000187:drug effects* / Q000254:growth & development; D010223:Parainfluenza Virus 2, Human / Q000187:drug effects* / Q000254:growth & development; D010849:Picornaviridae / Q000187:drug effects*; D018108:Respirovirus / Q000187:drug effects*; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*
D012263:Ribonucleosides; D012254:Ribavirin