Cross-resistance of transformed mouse cells to some drugs.
The Colcemid-resistant L--53 cell strain was examined for cross-resistance to metaphase inhibotors (Vincristine, Vinblastine, estradiol-17beta), an antitumor antibiotic (Rubomycin C) and an alkylating agent (Lycurim), compared with the Colcemid-sensitive L cells. The L-53 cells proved to be resistant besides colchicine to Vincristine, Vinblastine and estradiol-17beta concerning their antimitotic effect. The comparison of the viability of L and L-53 cells in the presence of Rubomycin C and Lycurim showed a resistance of the L-53 cells to Rubomycin C, while the effect of Lycurim was the same on both cell lines. The chromosome-mutagenic action of Lycurim was also equal on both cell lines.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D046508:Culture Techniques; D003630:Daunorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D004896:Erythritol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D007739:L Cells / Q000187:drug effects*; D008698:Mesylates / Q000494:pharmacology*; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens; D014747:Vinblastine / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D008698:Mesylates; D009153:Mutagens; D004958:Estradiol; D014750:Vincristine; D014747:Vinblastine; D004896:Erythritol; C000288:ritrosulfan; D003630:Daunorubicin