Anti-"i" antibody and hemolytic anemia associated with spontaneous cytomegalovirus mononucleosis.
Hemolytic anemia occurred in a 23-year-old woman with spontaneous cytomegalovirus mononucleosis who had not received a blood transfusion. The patient's serum gave positive reactions in Coombs' antiglobulin test with human cord erythrocytes but did not react with adult "O" cells. Complement-fixation antibody titers against cytomegalovirus and levels of activity against cord erythrocytes increased as the anemia worsened and remained at high levels when recovery from the anemia occurred.
D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D000942:Antigens, Bacterial; D001789:Blood Group Antigens; D003168:Complement Fixation Tests; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007048:I Blood-Group System; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology
D000906:Antibodies; D000942:Antigens, Bacterial; D001789:Blood Group Antigens; D007048:I Blood-Group System