Interferon inducers and foot-and-mouth disease vaccines: influence of two synthetic polynucleotides on antibody response and immunity in guinea pigs and swine.
Polyriboadenylic-polybouridylic acid enhanced the immunological response of guinea pigs to aqueous foot-and-mouth disease virus vaccine. Polyriboninosinic-polyribocytidylic acid enhanced the early antibody production of swine to oil emulsified foot-and-mouth disease virus vaccine. Polyriboninosinic-polyribocytidylic acid alone did not stimulate resistance to foot-and-mouth disease in swine.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D005537:Aphthovirus / Q000276:immunology*; D007109:Immunity / Q000187:drug effects*; D007279:Injections, Subcutaneous; D011063:Poly A-U / Q000008:administration & dosage / Q000494:pharmacology*; D011070:Poly I-C / Q000008:administration & dosage / Q000494:pharmacology*; D013552:Swine / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage
D000914:Antibodies, Viral; D014765:Viral Vaccines; D011063:Poly A-U; D011070:Poly I-C