The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells.
The mitogenic response of murine lymphocytes to the lymphocytosis-promoting factor of Bordetella pertussis has been shown to be due to activation of T cells. The selectivity of responsiveness to LPF with respect to the population of T cells which is stimllated, differs from that of PHA as well as Con A, and the surface receptors are different. A population of adherent cells, which does not appear to consist of macrophages or other phagocytic cells, is required for the T-cell response.
D000818:Animals; D000961:Antilymphocyte Serum; D001426:Bacterial Proteins / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000276:immunology*; D002448:Cell Adhesion; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007519:Isoantigens; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008218:Lymphocytosis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008623:Mercaptoethanol / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D008854:Microscopy, Electron; D013154:Spleen / Q000276:immunology / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D001426:Bacterial Proteins; D007519:Isoantigens; D037102:Lectins; D003208:Concanavalin A; D008623:Mercaptoethanol