Properties of the viruses selected during persistent infection of L cells with VSV.
Two virus clones, VSV-mp and VSV-sp, were isolated from L cells persistently infected with VSV (New Jersey serotype). Both clones were more temperature sensitive than the parent virus, VSV-o, and grew more slowly, gave smaller plaques, less c.p.e. and lower virus yields in L cells. Unlike the parent virus, both persistent viruses induced interferon production in L cells. Stable carrier cultures could be obtained from L cells infected with VSV-sp at low multiplicities without pretreatment with interferon. This may be related to the fact that VSV-sp is more sensitive to interferon than either VSV-mp or VSV-o.
D002459:Cell Fusion; D003588:Cytopathogenic Effect, Viral; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology; D007739:L Cells; D009154:Mutation; D013696:Temperature; D018116:Vesiculovirus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D014779:Virus Replication
D007372:Interferons