Effects of adrenocortical steroids and of adrenocorticotrophic hormone on (Na+-K+)-ATPase in immature cerebral cortex.
The effect of cortisol, methylprednisolone, and ACTH on (Na+-K+)-ATPase activity in developing cerebral cortex has been measured. Stimulation of (Na+-K+)-ATPase by these agents has been found in whole brain homogenates of kittens as early as age 8 days, and in whole homogenates and light microsomal fractions in young rats at 14 and 28 days. (Na+-K+)-ATPase activity in animals treated with corticosteroids or ACTH for 4 days was found to be 15--30% higher than activity in littermate controls. Brain potassium concentrations was increased in 14-day-old rats treated with methylprednisolone.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D002415:Cats; D008775:Methylprednisolone / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium; D008775:Methylprednisolone