title: Pathophysiology of psoriasis.
abstract: Psoriasis is a disease characterized by benign but unrestricted epithelial growth. The molecular pathophysiology of this unregulated growth has been discussed. A better understanding of the role of the cell surface, cyclic nucleotides, arachidonic acid-prostaglandin metabolism, and polyamines in psoriasis may clarify our understanding of this disease and produce clues pertinent to a general understanding of growth regulation.
mesh_terms: D002462:Cell Membrane / Q000276:immunology / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D006680:HLA Antigens; D006801:Humans; D009712:Nucleotides, Cyclic / Q000502:physiology*; D011073:Polyamines / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D011565:Psoriasis / Q000503:physiopathology*; D012867:Skin / Q000503:physiopathology* / Q000648:ultrastructure; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
chemical_list: D006680:HLA Antigens; D009712:Nucleotides, Cyclic; D011073:Polyamines; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D013096:Spermine; D000242:Cyclic AMP; D006152:Cyclic GMP; D013095:Spermidine