Studies on the effect of various agents on the maturation of thymus stem cells.
Experiments were carried out on 14-day fetal mouse thymic stem cells which were treated with agents known to increase cellular cAMP levels for a period of 90 min at 37 degrees C. When compared to controls, a high proportion of treated stem cells were found to develop Thy-1 (theta) antigen as indicated by dye exclusion tests using anti-Thy-1 serum and complement.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D007519:Isoantigens; D051379:Mice; D008807:Mice, Inbred BALB C; D011453:Prostaglandins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000196:embryology* / Q000276:immunology
D007519:Isoantigens; D011453:Prostaglandins; D003994:Bucladesine; D000242:Cyclic AMP