Effect of 1,25-dihydroxycholecalciferol on adenosine 3',5'-cyclic monophosphate production in calvaria of mice.
1,25-dihydroxycholecalciferol (1,25-(OH)2D3), added at doses which stimulate bone resorption in the system used, did not increase adenosine 3',5'-cyclic monophosphate (cAMP) production in vitro in mouse calvaria incubated for up to 48 h. Thus 1,25-(OH)2D3 does not appear to stimulate bone resorption through involvement of an increased cAMP production.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000096:biosynthesis*; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D051379:Mice
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D000242:Cyclic AMP