Insulin inhibits cellular and herpes simplex virus DNA synthesis in transformed lymphoblastoid cell lines.
Treatment of uninfected and herpes simplex virus-infected lymphoblastoid cells with 4 units of insulin per milliliter resulted in the inhibition of both cellular and viral DNA synthesis.
D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis*; D004854:Herpesvirus 4, Human; D007328:Insulin / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology
D004273:DNA, Neoplasm; D004279:DNA, Viral; D007328:Insulin; D015032:Zinc