[Familial hypobetalipoproteinaemia and diabetes mellitus (author's transl)].
In a 60-year-old patient with manifest diabetes mellitus and in his 63-year-old brother with latent diabetes mellitus hypobeta-lipoproteinaemia was diagnosed. Cholesterol values were around 1,8 mmol/1 in whole serum samples. The LDL-cholesterol fraction was 1,04 mmol/1. The beta-lipoprotein band in the lipoprotein electrophoresis was markedly reduced. Apolipoprotein B measured by radial immuno-diffusion was about 30% of the normal for age. The components of LDL were normal. Values of hepatic triglyceride lipase and lipoprotein lipase in heparinised plasma were within the normal range. The simultaneous occurrence of hypobetalipoproteinaemia and diabetes mellitus is described here for the first time.
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol
Familiäre Hypobetalipoproteinämie und Diabetes mellitus.