title: Induction of melanogenesis in the epidermal melanoblasts of newborn mouse skin by MSH.
abstract: The number of melanocytes positive to the dopa reaction in the epidermis was shown to increase after newborn mice were injected with alpha-MSH or DBc-AMP. The agents seemed to induce the initiation of melanogenesis in the pre-existing melanoblasts. Electron-microscopic observation also demonstrated that alpha-MSH induced not only maturation of melanosomes but also the formation of melanosomes.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D008543:Melanins / Q000096:biosynthesis*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D008544:Melanocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D008543:Melanins; D003994:Bucladesine; D009074:Melanocyte-Stimulating Hormones