title: Effects of ACTH 4-10 on ECT-induced memory dysfunctions.
abstract: Double-blind studies of ACTH 4-10 and placebo were conducted in psychiatric patients receiving bilateral ECT to determine whether the polypeptide exerted anti-amnesic effects. Observations after a single ECT were suggestive of some positive effects, but studies between seizures after five or six ECTs showed no significant drug-placebo differences. Although the findings were largely negative, they do not rule out positive effects of ACTH 4-10 on memory. Possibly the designs and timing of the experiments and/or the dosages of ACTH 4-10 employed were unsuitable for demonstrating such influences.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous; D007858:Learning; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000324:Adrenocorticotropic Hormone