title: [Immunogenicity and toxicity of soluble trichloroacetic acid precipitate from pertussis microbes and its fractions].
abstract: The authors studied the biological properties of the preparations of pertussis protective antigens obtained by the disintegration of the microbial mass of Bordetella pertussis, with the subsequent purification with trichloracetic acid (TCA-preparations). TCA-preparations proved to possess a stable protective activity and by the ratio of the protective dose to toxic and histamine-sensitizing doses considerably exceeded the corpuscular vaccine. A TCA-preparation fraction with a greater immunogenic activity than the initial preparation was obtained by chromatography on sepharose 4B.
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D001886:Bordetella pertussis / Q000276:immunology*; D051379:Mice; D010567:Pertussis Vaccine / Q000633:toxicity; D014238:Trichloroacetic Acid
chemical_list: D000942:Antigens, Bacterial; D010567:Pertussis Vaccine; D014238:Trichloroacetic Acid
vernacular_title: Immunogennost' i toksichnost' rastvorimogo osazhdaemogo trikhlorouksusnoĭ kislotoĭ preparata iz kokliushnykh mikrobov i ego fraktsiĭ.