A carcinogenicity assay of Mirex in Charles River CD rats.
The long-term administration of 50 and 100 ppm of Mirex in the diets of male and female Charles River CD rats was associated with a spectrum of liver lesions, from foci or areas of cellular alteration and neoplastic nodules to hepatocellular carcinoma. Statistically significant numbers of neoplastic nodules were observed in the livers of male rats receiving the high dose. Neoplastic nodules and hepatocellular carcinomas were not observed in control rats.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D007942:Leukemia, Experimental / Q000139:chemically induced; D008107:Liver Diseases / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D008917:Mirex / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010911:Pituitary Neoplasms / Q000139:chemically induced; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced; D014565:Urogenital Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D007306:Insecticides; D008917:Mirex