Carbohydrate metabolism of heat-acclimated hamsters. V. Control of gluconeogenesis.
The rate of gluconeogenesis was similar in liver of both fed heat-acclimated and control hamsters. Twenty-four hours of fasting calsed 6 times elevation in hepatic gluconeogenesis of the control animals whereas only 4 times enhancement of this pathway was found in heat-acclimated animals. Thus, significant difference existed between the two experimental groups in fasting. Triiodothyronine stimulated the rate of gluconeogenesis only in fed heat-acclimated hamsters whereas dibutyryl cyclic AMP caused elevation of this pathway in liver slices of fed control hamsters only. The results suggest that a decrease in hepatic gluconeogenesis in heat acclimation occurs only in fasted animals and it is controlled by thyroid hormones.
D000064:Acclimatization; D000818:Animals; D006224:Cricetinae; D000242:Cyclic AMP / Q000494:pharmacology; D005215:Fasting; D005943:Gluconeogenesis / Q000187:drug effects; D006358:Hot Temperature; D066298:In Vitro Techniques; D008099:Liver / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D000242:Cyclic AMP