Mobilization of CFU-C by exercise and ACTH induced stress in man.
This study was designed to investigate physiological factors that affect blood CFU-C numbers. Exercise was found to produce a fourfold rise in blood colony forming cells, and a twofold rise in cluster forming cells accompanied by a lymphocytosis. ACTH-induced stress caused a twofold rise in blood colony and cluster forming cells accompanied by a neutrophil leucocytosis. The results suggest that blood CFU-C exchange with a large marginal pool as well as a bone marrown pool. The procedures described could be exploited in the use of leukapheresed nucleated cells as a source of stem cells for bone marrow transplantation.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000328:Adult; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D005082:Physical Exertion
D000324:Adrenocorticotropic Hormone