Lack of effect on cyclic GMP content of cells treated with mycophenolic acid.
Mycophenolic acid, an oncolytic agent and a known inhibitor of guanine ribonucleotide synthesis, has proven to be an effective drug against psoriasis. With reports of greater guantities of c-GMP in psoriatic tissues than in normal tissue, and with the correlation of c-GMP content of cells to proliferation, the effect of mycophenolic acid on cellular c-GMP was investigated. When HeLa, green monkey BSC-1, and mouse L-cells were treated with inhibitory concentrations of mycophenolic acid, no decrease in c-GMP was observed from that of untreated cells. Though mycophenolic acid inhibits guanine ribonucleotide synthesis, this inhibition does not extend to c-GMP synthesis. The inhibition of proliferation of cells by mycophenolic acid then does not include the inhibition of synthesis of c-GMP, but apparently resides solely in limiting the guanylate necessary for nucleic acid synthesis.
D002452:Cell Count; D002460:Cell Line; D006152:Cyclic GMP / Q000378:metabolism*; D006151:Guanosine / Q000494:pharmacology; D006367:HeLa Cells / Q000378:metabolism; D007739:L Cells / Q000378:metabolism; D009173:Mycophenolic Acid / Q000494:pharmacology*
D006151:Guanosine; D006152:Cyclic GMP; D009173:Mycophenolic Acid