Discussion paper: loss of cellular antigens during malignant transformation.
Normal human diploid cells, such as WE-38, transformed by an oncogenic virus, SV40, are greatly depleted of a cathodal esterase isozyme using both immunological and enzymatic criteria. This cathodal esterase is primate-specific and associated with lysosomes of many different tissue cells. It provides a clear example of antigenic loss associated with malignant change.
D000941:Antigens; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004950:Esterases / Q000378:metabolism*; D006822:Hybrid Cells / Q000201:enzymology; D007526:Isoelectric Point; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011120:Polyomavirus; D013539:Simian virus 40; D013045:Species Specificity
D000941:Antigens; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D004950:Esterases