title: [The significance of dietary fat in arteriosclerosis. An outmoded theory? (author's transl)].
abstract: The high cholesterol content of an atheroma, the frequent occurrence of myocardial infarction with high serum cholesterol, the extensive arteriosclerotic changes in diseases with high serum cholesterol (nephrosis, myxedema) and the occurrence of cholesterol deposits in the aorta in some animals fed with cholesterol are the principal arguments for the lipid theory of arteriosclerosis. But since many observations contradict this theory and the composition of the atheroma is the same as for many granulation tissues which are interpreted as a healing process, it is postulated that atheroma tissue is also to be interpreted as part of a reparative process. Such a hypothesis could explain all the well-known arteriosclerotic changes. Longterm studies in man for testing the serum cholesterol-lowering action of the "unsaturated" vegetable oils include serious errors of method and permit no confirmed conclusions.
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D002645:Chickens; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005260:Female; D006097:Granulation Tissue; D000882:Haplorhini; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006949:Hyperlipidemias / Q000235:genetics; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood; D011817:Rabbits; D051381:Rats
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008077:Lipoproteins, LDL
vernacular_title: Bedeutung der Nahrungsfette bei der Arteriosklerose. Eine überholte Theorie