Augmentation of the in vitro mitogenic response of owl monkey peripheral blood lymphocytes by levamisole and loss of this effect with the development of herpesvirus saimiri-induced lymphoma.
Levamisole (LMS) has been shown to be capable of enhancing the proliferative response of normal owl monkey peripheral blood lymphocytes (PBL) to PHA, and, to a lesser degree, of increasing the level of spontaneous DNA synthesis. With the development of herpesvirus saimiri-induced lymphoma, these stimulatory responses were lost. LMS was not capable of stimulating tumour cells to normal functions, or of reversing the disease-induced suppressed functions on normal cells.
D000818:Animals; D001029:Aotus trivirgatus / Q000276:immunology; D004247:DNA / Q000096:biosynthesis; D000882:Haplorhini; D006566:Herpesviridae Infections / Q000276:immunology*; D006567:Herpesvirus 2, Saimiriine; D007978:Levamisole / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008223:Lymphoma / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D014412:Tumor Virus Infections / Q000276:immunology*
D010835:Phytohemagglutinins; D007978:Levamisole; D004247:DNA