Cyclic AMP levels in cerebrospinal fluid in manic-melancholic patients.
The concentrations of adenosine 3'5'-cyclic monophosphate (cyclic AMP) in cerebrospinal fluid (CSF) in manic-melancholic patients were studied. As control groups served patients suffering from other psychiatric disorders as well as neruological and orthopedic patients. The results showed no difference between the various diagnostic groups, including melancholic versus manic patients, unipolar versus bipolar types. The severity of the affective states measured by rating scales showed no correlation to cyclic AMP levels in CSF. The cyclic AMP levels were apparently not influenced by electroconvulsive therapy or treatment with lithium, neuroleptica, or tricyclic antidepressants.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000628:therapy; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D003863:Depression / Q000134:cerebrospinal fluid / Q000628:therapy; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D014149:Tranquilizing Agents / Q000627:therapeutic use
D000929:Antidepressive Agents, Tricyclic; D014149:Tranquilizing Agents; D008094:Lithium; D000242:Cyclic AMP