Natural transmission of gibbon leukemia virus.
Gibbon leukemia virus can infect prenatal gibbons through in utero infection or postnatal gibbons through contact transmission. The transmission of infectious virus was from viremic gibbons and not from uninfected or antibody-positive animals. The two modes of transmission could be distinguished by the amount of proviral DNA integrated into the muscle tissue of viremic gibbons. Muscle of gibbons infected postnatally had little or no proviral DNA, whereas gibbons infected prenatally had a large quantity of proviral DNA.
D000818:Animals; D000914:Antibodies, Viral; D002353:Carrier State; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015186:Hominidae / Q000382:microbiology*; D006922:Hylobates / Q000382:microbiology*; D007938:Leukemia / Q000151:congenital / Q000635:transmission / Q000662:veterinary*; D008297:Male; D008431:Maternal-Fetal Exchange; D009132:Muscles / Q000032:analysis; D011247:Pregnancy; D012190:Retroviridae / Q000276:immunology; D014412:Tumor Virus Infections / Q000151:congenital / Q000635:transmission / Q000662:veterinary*
D000914:Antibodies, Viral; D004279:DNA, Viral