title: Mode of interaction of different polyanions with the first (C1,C1) the second (C2) and the fourth (C4) component of complement. IV. Activation of C1 in serum by polyanions.
abstract: Treatment of serum with dextransulphate polyvinylsulphate or polyanetholsulphonate resulted in a dose-dependent activation of C1 and C3; this was found for normal serum as well as for C4-deficient guinea-pig serum. Activation of C1 and C3 occurred at the same concentration of polyanions. The consumption of C3 in C4 deficient serum and the requirement of factor D of the alternative pathway indicate that C3 is activated via the alternative pathway.
mesh_terms: D000818:Animals; D000838:Anions / Q000494:pharmacology*; D003172:Complement C1; D003175:Complement C2; D003176:Complement C3 / Q000096:biosynthesis; D003181:Complement C4; D003165:Complement System Proteins; D003911:Dextrans / Q000494:pharmacology; D006168:Guinea Pigs / Q000276:immunology; D006461:Hemolysis; D066298:In Vitro Techniques; D011074:Polyanetholesulfonate / Q000494:pharmacology; D011145:Polyvinyls / Q000494:pharmacology
chemical_list: D000838:Anions; D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003911:Dextrans; D011145:Polyvinyls; D011074:Polyanetholesulfonate; D003165:Complement System Proteins