Stimulus effects of delta(9)-THC and its interaction with naltrexone and catecholamine blockers in rats.
Rats trained in a T-shaped maze to discriminate the effects of i.p. injections of delta(9)-tetrahydrocannabinol (delta(9)-THC, 4 mg/kg) and the effects of the vehicle were tested for antagonism and generalization to the delta(9)-THC stimulus by naltrexone (4 mg/kg), haloperidol (0.32 mg/kg), propranolol (20 mg/kg), and phenoxybenzamine (10 mg/kg). None of these drugs blocked the delta(9)-THC stimulus, nor were they found to generalize to delta(9)-THC.
D000818:Animals; D002395:Catecholamines / Q000037:antagonists & inhibitors*; D010856:Columbidae; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000037:antagonists & inhibitors*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects
D002395:Catecholamines; D011942:Receptors, Adrenergic, alpha; D009270:Naloxone; D009271:Naltrexone; D013759:Dronabinol