Conformational analysis of polynucleotides. I. The favorable left-handed helical model for the poly(8,2'-S-cycloadenylic acid) with high anti conformation.
1) Energy calculations have shown that poly (8,2'-S-cycloadenylic aicd) can form left-handed helices owing to the high anti conformation. 2) Two favorable left-handed helices are characterized by axial translation per residue (Z=4.3 and 3.6A) and by rotations per residue (theta= 40 degrees and -25 degrees). 3) The proposed helical models might be stable in aqueous solution and is well explicable of the optical property of this compound.
D001665:Binding Sites; D000242:Cyclic AMP / Q000031:analogs & derivatives*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011061:Poly A / Q000031:analogs & derivatives*; D013816:Thermodynamics
D011061:Poly A; D000242:Cyclic AMP