Resistance to murine cytomegalovirus linked to the major histocompatibility complex of the mouse.
Studies of the resistance patterns to infection with a murine cytomegalovirus in inbred strains of mice revealed the existence of resistant and susceptible strains. Resistance was found to be associated with possession of the H-2k allele at the major histocompatibility locus of the mouse. The F1 hybrid between a resistant strain (C3H/HeJ) and a susceptible strain (BALB/c) was found to have a resistance intermediate between that of both parents, indicating that the gene(s) controlling resistance is partly dominant. Susceptible BALB/c mice could be made resistant to lethal infection by pre-treatment with thioglycollate broth but not by pre-treatment with endotoxin or BCG. Resistant C3H/HeJ mice could be made susceptible to lethal infection by pre-treatment with cyclophosphamide.
D000483:Alleles; D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D004731:Endotoxins / Q000627:therapeutic use; D005799:Genes, Dominant; D006648:Histocompatibility; D006824:Hybridization, Genetic; D051379:Mice; D008815:Mice, Inbred Strains; D012486:Salmonella typhimurium; D013045:Species Specificity; D013864:Thioglycolates / Q000627:therapeutic use
D001500:BCG Vaccine; D004731:Endotoxins; D013864:Thioglycolates; D003520:Cyclophosphamide