title: Evidence for increased degeneration of mitochondria in old rats. A brief note.
abstract: An isotonic density gradient technique for separating mitochondria into two major components was applied to mitochondria isolated from young and old rats. Respiratory measuremtns indicate that the depression of state 3 respiration rates observed in the mitochondria from old rats when glutamate--malate is used as a substrate is due primarily to the faster sedimenting mitochondrial component.
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D002458:Cell Fractionation; D003574:Cytochrome c Group / Q000494:pharmacology; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats
chemical_list: D003574:Cytochrome c Group