The effect of insulin treatment on the metabolic response to glucagon in diabetes.
The metabolic response to intravenous glucagon was studied in insulin requiring diabetes before, 1 week and 1 month after treatment with insulin. The rise in plasma 3-hydroxybutyrate following glucagon in the untreated state was converted to a fall after 1 month on insulin. It is suggested that this response could provide a measure of the biological effectiveness of circulating insulin. There was no change in plasma cyclic AMP response to glucagon after treatment with insulin.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005934:Glucagon; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D005934:Glucagon; D000242:Cyclic AMP