title: [The effect of newer anthelmintics on Fasciola hepatica in experimentally infected rats].
abstract: The reports deals with the results of testing seven new antihelminthics for Fasciola hepatica in the experimentally invaded Wistar rat. The greatest influence on juvenile flukes (2 and 4 weeks of age) was exerted by diamphenetid (Coriban) applied in a single dose of 100 mg kg-1. Hexachlorophene applied in the dose of 50 mg kg-1 showed the highest effect on sexually mature flukes. All the tested antihelminthics of the halogenated salicylanilide group were ineffective on juvenile stages and only slightly effective on mature F. hepatica flukes. It follows from the results that the effectiveness of some antifasciolics on laboratory animals need not always be in correlation with their effect in ruminants - hence it is necessary to verify the results obtained in laboratory animals and to check them on natural F. hepatica hosts.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D003957:Diamfenetide / Q000494:pharmacology; D004338:Drug Combinations; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy; D006582:Hexachlorophene / Q000494:pharmacology; D009611:Nitroxinil / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010097:Oxyclozanide / Q000494:pharmacology; D011075:Polybrominated Biphenyls / Q000494:pharmacology; D011888:Rafoxanide / Q000494:pharmacology; D051381:Rats; D012458:Salicylanilides / Q000494:pharmacology
chemical_list: D000871:Anthelmintics; D004338:Drug Combinations; D009943:Organophosphorus Compounds; D011075:Polybrominated Biphenyls; D012458:Salicylanilides; D010097:Oxyclozanide; D011888:Rafoxanide; D009611:Nitroxinil; D006582:Hexachlorophene; D003957:Diamfenetide
vernacular_title: Ucinok novsích antihelmintík na motolicu Fasciola hepatica u experimentálne invadovaného potkana