Benign epithelial nephroblastoma. A contribution to its histogenesis.
The occurrence of a malignant Wilms'tumor in the right kidney and of a benign epithelial nephroblastoma in the left kidney of a 5-year-old girl is reported. Both kidneys contained foci of persistent well differentiated blastema. In the left kidney a direct transformation of the primitive metanephric epithelium into a benign nephroblastoma is shown. This finding suggests an origin of epithelial nephroblastoma from persistent nephrogenic tissue and indicates that the former represents the benign counterpart of the malignant Wilms'tumor.
D002454:Cell Differentiation; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D009396:Wilms Tumor / Q000473:pathology*