title: [Clinical and morphological studies in a case of congenital glaucoma combined with an ocular-dental-digital dysplasia (author's transl)].
abstract: Clinical and morphological studies were undertaken to characterize a case of congenital glaucoma combined with an ocular-dental-digital dysplasia in a two year old patient. Light and electromicroscopic investigations of a surgically removed trabecular specimen were carried out. A trabeculotomy had been performed at this exact site 10 months prior to removal. The existence of a canal of Schlemm was demonstrated. The regular trabecular meshwork and trabecular region was replaced by fairly dense scar tissue, containing rudimentary intertrabecular spaces. Proliferating corneal endothelial cells covered the wound area up to the uveal part of the trabecular region. The morphological findings correlated well with the clinical observation of continued raised intraocular pressure despite trabeculotomy. It is concluded that, contrary to the situation in adult onset glaucoma, the strong proliferative tendency of juvenile tissue has a marked influence on the postoperative efficacy of the trabeculotomy.
mesh_terms: D002675:Child, Preschool; D004727:Endothelium / Q000648:ultrastructure; D005260:Female; D005901:Glaucoma / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008850:Microphthalmos / Q000150:complications* / Q000473:pathology; D013576:Syndactyly / Q000150:complications; D014071:Tooth Abnormalities / Q000150:complications; D014129:Trabecular Meshwork / Q000473:pathology / Q000601:surgery* / Q000648:ultrastructure
vernacular_title: Klinische und morphologische Untersuchungen eines kongenitalen Glaukoms bei okulo-digito-dentalem Syndrom