title: [A case of virilizing adrenal cortical adenoma whose steroid profile evokes a partial 21-hydroxylase deficiency (author's transl)].
abstract: The C19 and C21 urinary steroids from a virilizing adrenal tumour with high levels of plasma 17 alpha-hydroxyprogesterone and its urinary metabolites have been identified and quantitated gas chromatography and mass spectrometry of sephadex fractions of the total urinary extract. A of the fifty-five identified steroids thirteen were compounds not found before in such a case. The actiology of the apparent 21-steroid hydroxtlase deficiency is discussed at the light of these analytical results and of the hormonogenesis enzymatic induction of the tumour biopsy.
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000652:urine*; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000652:urine*; D000310:Adrenal Gland Neoplasms / Q000652:urine*; D003677:Deficiency Diseases / Q000209:etiology; D006801:Humans; D006908:Hydroxyprogesterones / Q000652:urine; D006899:Mixed Function Oxygenases / Q000172:deficiency; D013256:Steroids / Q000652:urine*
chemical_list: D006908:Hydroxyprogesterones; D013256:Steroids; D006899:Mixed Function Oxygenases
vernacular_title: Un cas d'adénome corticosurrénalien virilisant présentant le profil hormonal d'un déficit partiel en 21-hydroxylase.