title: Disaggregation of hydroxyapatite crystals.
abstract: A system has been developed to measure quantitatively the disaggregation of hydroxyapatite crystals. Disaggregation was induced by pyrophosphate, ethane-1-hydroxy-1,1-diphosphonate, dichloromethylene diphosphonate, haparin and citrate. Hyaluronic acid stimulated aggregation at low concentrations and disaggregation at high concentrations. Lactate had no effect. The possible role disaggregation might play in the resorption of calcified tissues in vivo id discussed.
mesh_terms: D001665:Binding Sites; D002951:Citrates; D003460:Crystallization; D011756:Diphosphates; D006025:Glycosaminoglycans; D006882:Hydroxyapatites; D007700:Kinetics; D007773:Lactates; D063065:Organophosphonates; D011485:Protein Binding
chemical_list: D002951:Citrates; D011756:Diphosphates; D006025:Glycosaminoglycans; D006882:Hydroxyapatites; D007773:Lactates; D063065:Organophosphonates