title: Human interferon and cell growth inhibition. I. Inhibitory effect of human interferon on the growth rate of cultured human cells.
abstract: Human interferon inhibited the growth rate of cultured human cells. These included diploid fibroblast cells from embryonal lung and skin, established lines of HeLa and U-amnion cells, all grown in monolayer; and the established lymphoblastoid line P3HR1 grown in suspension. Cells growing fast were inhibited to a higher degree than those growing slowly. The inhibitory effect was dose dependent but the dose-dependency was different in various cell types. The inhibitory effect of leukocyte interferon and fibroblast interferon was quantitatively comparable.
mesh_terms: D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects
chemical_list: D007372:Interferons