Production of interferon in human diploid cell cultures.
Eleven human diploid cell lines were compared for their ability to produce interferon in response to Newcastle Disease Virus. Sensitivity of the cultures of MM, Sindbis VSV and VR viruses was also studied. Human cells derived from various tissue of a single embryo responded variably to interferon inducer. Using selected viruses interferon production was studied in two systems, in cultures of leukocytes and in human embryonic cells.
D000818:Animals; D001717:Birds; D002478:Cells, Cultured; D002642:Chick Embryo; D004171:Diploidy; D004622:Embryo, Mammalian / Q000276:immunology*; D004625:Embryo, Nonmammalian; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D009522:Newcastle disease virus / Q000276:immunology*; D012845:Sindbis Virus / Q000276:immunology; D014616:Vaccinia virus / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
D007372:Interferons