[Chloroquine neuromyopathy. One case in prophylactic maleriatherapy (author's transl)].
A case of neuromyopathy due to chronic chloroquine intoxication is reported. The neuromyopathy developped 9 months after malaria suppression therapy with chloroquine was started. The clinical picture was that of a peripherical neuropathy in the lower limbs and of a generalized myasthenic syndrome. Muscular biopsy showed typical pictures of "vacuolar myopathy". The metabolism of the drug was normal. The patient improved soon after chloroquine was discontinued.
D000328:Adult; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D002738:Chloroquine
Neuromyopathie à la chloroquine. Un cas au cours d'un traitement prophylactique antipaludique.