[Induction of cytochrome P-450 and b5 of the mouse liver by phenytoin during chronic hypoxia (Fi02 : 0,08)].
During chronic hypoxia at sea level (FiO2 : 0,08) the liver concentrations of cytochrome P 450 and b5 decreased. Phenytoin administration induces an increase in cytochrome P 450 and b5 liver content. The hydroxylation of phenytoin that was decreased at low level of cytochrome P 450 and oxygen, reached again a normal level after induction of cytochrome P 450 in spite of the persistency of a low level of available oxygen. Liver cytochrome P 450 concentration is the main limiting factor of phenytoin hydroxylation.
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism; D003580:Cytochromes / Q000096:biosynthesis* / Q000378:metabolism; D004790:Enzyme Induction; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology*; D008099:Liver / Q000187:drug effects*; D051379:Mice; D010672:Phenytoin / Q000378:metabolism / Q000494:pharmacology*
D003580:Cytochromes; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System; D005952:Glucose-6-Phosphatase
Induction des cytochromes P 450 et b5 du foie de souris par la phénytoïne au cours d'une hypoxie chronique (FiO2 : 0,08)