Effect of heterologous antimacrophage serum on growth of Rous virus-induced sarcoma in the allogeneic and syngeneic system.
The effect of heterologous antimacrophage serum (AMS) and normal rabbit serum (NRS) on the immune reaction against Rous virus-induced sarcoma (RSL) was studied in rats. The growth of RSL sarcoma transplanted against the H-1 barrier in AMS-treated rats was more progressive than in the untreated or NRS-treated control group. On the other hand, the growth of RSL sarcoma was significantly suppressed in syngeneic AMS- or NRS-treated recipients compared to the untreated control rats.
D000818:Animals; D005260:Female; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D001357:Sarcoma, Avian / Q000276:immunology* / Q000473:pathology; D014183:Transplantation, Heterologous
D006649:Histocompatibility Antigens; D007106:Immune Sera