Silica toxicity for macrophages in vitro: a new cytotoxicity test.
Soluble factors released from silica-damaged macrophages inhibit proliferation of various haematopoietic cells in long term cultures. The same holds true for damage induced by heat, non-physiological pH, freezing and thawing. This phenomenon is dose-dependent and correlates with the degree of macrophage viability. Thus, a base for measuring the amount of damage to the macrophage is established.
D000818:Animals; D002450:Cell Communication; D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D006413:Hematopoietic System / Q000166:cytology; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008722:Methods; D051379:Mice; D012822:Silicon Dioxide / Q000633:toxicity*
D012822:Silicon Dioxide