title: Observed relationship between herpetic lesions and antigenic type of Herpesvirus hominis.
abstract: Of 171 available strains of Herpesvirus hominis isolated in this laboratory during the period 1950 to 1975, 166 could be readily typed as HV-1 or HV-2 by indirect immunofluorescence, while 5 have so far been untypable. Of 72 typable isolates from genitalia and nearby skin, all were HV-2. Of 81 typable isolates from mouth, eye or skin above the waist, 68(84%) were HV-1 and 13(16%) were HV-2. Of isolates from the eye only, 46 of 54(87%) were HV-1, 7(13%) were HV-2, and 1 could not be typed. When sera were available for herpesvirus antibody titrations, the pattern of antibody response tended to match the type of isolate. Clinical findings of 5 of the individuals with ocular herpes caused by HV-2 have been reviewed. The HV-2 infections appeared to be severe, typical herpetic keratoconjunctivitis, sometimes with deep infiltrates and stromal involvement.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral; D002642:Chick Embryo; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D007635:Keratitis, Dendritic / Q000276:immunology; D051379:Mice; D009500:Neutralization Tests; D012703:Serotyping; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral