Escherichia coli DNA synthesis in vitro: insensitivity of ATP-dependent DNA repair to inhibition by novobiocin.
Novobiocin, an effective inhibitor of DNA replicaion in Escherichia coli, is shown to have no effect on the ATP-dependent DNA repair carried out by toluenized cells after ultraviolet irradiation. Therefore novobiocin can be considered a selective inhibitor of replicative DNA synthesis in vitro.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D006157:Guanosine Monophosphate / Q000378:metabolism; D007700:Kinetics; D009268:Nalidixic Acid / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology*; D010093:Oxolinic Acid / Q000494:pharmacology; D014466:Ultraviolet Rays
D009675:Novobiocin; D009268:Nalidixic Acid; D006157:Guanosine Monophosphate; D000255:Adenosine Triphosphate; D004247:DNA; D010093:Oxolinic Acid