Psychoses precipitated by psychotomimetic drugs. A follow-up study.
Fifteen patients who developed prolonged psychotic reactions following psychotomimetic drug use (probably primarily LSD) were followed up 1.9 to 5.8 years later. Two patients had committed suicide. Approximately half of the patients had a relatively good outcome and half did poorly. Aspects of the initial clinical picture that correlated with outcome measures are discussed. The possibility is considered that vulnerability to a prolonged psychotic reaction following psychotomimetic drug use may be related to a genetic vulnerability to illnesses in the manic-depressive/schizo-affective spectrum. In some instances this vulnerability may implicate central serotonergic neuronal systems.
D000293:Adolescent; D000328:Adult; D000359:Aftercare; D000662:Amphetamines / Q000009:adverse effects; D001714:Bipolar Disorder / Q000235:genetics; D002746:Chlorpromazine / Q000627:therapeutic use; D004198:Disease Susceptibility; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects*; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects; D008297:Male; D008635:Mescaline / Q000009:adverse effects; D010359:Patient Readmission; D011379:Prognosis; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012917:Social Adjustment; D019966:Substance-Related Disorders / Q000150:complications*; D013405:Suicide
D000662:Amphetamines; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D008238:Lysergic Acid Diethylamide; D008635:Mescaline; D002746:Chlorpromazine