title: [Intestinal vasoactive peptide receptors in enterocytes : specific binding and stimulation of cyclic AMP].
abstract: Receptors for the vasoactive intestinal peptide (VIP) were characterized on enterocytes isolated from Rat small intestine. Native VIP inhibited competitively the binding of 125I-VIP to enterocytes and strongly stimulated cyclic AMP production; both these effects were observed for concentrations of VIP as low as 0.5-1.0 ng/ml (0.15-0.30 nM) which are compatible with the VIP concentration in the gut.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011956:Receptors, Cell Surface; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D005768:Gastrointestinal Hormones; D011956:Receptors, Cell Surface; D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP
vernacular_title: Récepteurs du peptide intestinal vasoactif (VIP) dans les entérocytes: liaison spécifique et stimulation de l'AMP cyclique.