Feline leukemia virus: biochemical and immunological characterization of gag gene-coded structural proteins.
The major non-glycosylated structural proteins of feline leukemia virus have been isolated, and competition immunoassays have been developed for each. These proteins include the 27,000- to 30,000-molecular-weight major internal antigen designated p30, a 15,000-molecular-weight protein (p15), an acidic protein of 12,000 molecular weight (p12), and a highly basic 10,000-molecular-weight protein (p10). Immunologically and biochemically corresponding proteins of feline and murine leukemia viruses have been identified. and, on the basis of analogy to the known sequence of a prototype type C virus of mouse origin, the map order of the gag region of the feline type C viral genome has been tentatively deduced as NH2-p15-p12-p10-COOH. The demonstration of two feline leukemia virus gag gene-coded proteins, p15 and p12, expressed in the form of an uncleaved precursor in a mink cell line nonproductively transformed  by feline sarcoma virus provides indirect support for the proposed sequence.
D000406:AKR murine leukemia virus / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D003429:Cross Reactions; D005796:Genes; D007118:Immunoassay; D005256:Leukemia Virus, Feline / Q000032:analysis* / Q000276:immunology; D008970:Molecular Weight; D011925:Rauscher Virus / Q000276:immunology; D012190:Retroviridae / Q000276:immunology; D014764:Viral Proteins / Q000032:analysis / Q000276:immunology
D000956:Antigens, Viral; D014764:Viral Proteins