Rosette formation by human T and B lymphocytes in the presence of adrenergic and cholinergic drugs.
It was shown that adrenergic drugs, which increase the intracellular levels of cAMP, inhibit the rosette formation by T-lymphocytes, but stimulate the rosettes produced by B-lymphocytes. Cholinergic drugs, which increase the levels of cGMP, on the contrary, stimulate the formation of rosettes by T-lymphocytes but inhibit those produced by B-lymphocytes.
D001285:Atropine / Q000494:pharmacology; D001337:Autonomic Agents / Q000494:pharmacology*; D001402:B-Lymphocytes; D003994:Bucladesine / Q000494:pharmacology; D002087:Butyrates / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007158:Immunologic Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010208:Papaverine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013601:T-Lymphocytes; D013806:Theophylline / Q000494:pharmacology
D001337:Autonomic Agents; D002087:Butyrates; D010862:Pilocarpine; D003994:Bucladesine; D001285:Atropine; D002217:Carbachol; D011433:Propranolol; D013806:Theophylline; D010208:Papaverine; D000242:Cyclic AMP; D006152:Cyclic GMP; D007545:Isoproterenol