Changes in cyclic GMP levels during forelimb regeneration in adult Notophthalmus viridescens.
Cyclic 3', 5'-guanosine monophosphate (cGMP) was measured at eight stages of forelimb regeneration in adult newts and compared with the cGMP levels of non-regenerating control limbs. There was a significant increase in cGMP content during dedifferentiation followed by a sharp decrease to minimal levels at the cone stage. A second smaller increase in cGMP occurred between the cone stage and mid-differentiation, followed by a decrease to relatively constant levels approaching control values as differentiation progressed. The changes in cGMP during dedifferentiation and during the period of highest cell proliferation indicate that cGMP may play a role in these processes. The smaller increases in cGMP levels during differentiation may reflect a reduced rate of cell division in the differentiating tissues.
D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005121:Extremities / Q000502:physiology*; D012038:Regeneration; D012455:Salamandridae / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors; D014562:Caudata / Q000502:physiology*
D004247:DNA; D006152:Cyclic GMP