Increased susceptibility to feline leukemia virus infection in cats exposed to methylnitrosourea.
Exposure of adult specific-pathogen-free cats to methylnitrosourea resulted in increased susceptibility to infection by feline leukemia virus. A greater proportion of cats exposed to methylnitrosourea and feline leukemia virus (69%) became persistently viremic than those exposed to feline leukemia virus alone (17%). Segmented neutrophils were reduced by 90 to 99% within 3 days following exposure to methylnitrosourea, (15 to 20 mg/kg) whereas the effects on lymphocytes and erythrocytes, although less obvious, were also detected.
D000818:Animals; D002415:Cats; D003043:Cocarcinogenesis; D006400:Hematocrit; D005256:Leukemia Virus, Feline; D007942:Leukemia, Experimental / Q000097:blood / Q000209:etiology*; D008231:Lymphopenia / Q000139:chemically induced; D008770:Methylnitrosourea / Q000633:toxicity*; D009503:Neutropenia / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D014412:Tumor Virus Infections / Q000209:etiology
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea