title: Purine synthesis and excretion in mutants of the WI-L2 human lymphoblastoid line deficient in adenosine kinase (AK) and adenine phosphoribosyltransferase (APRT).
mesh_terms: D000228:Adenine Phosphoribosyltransferase / Q000172:deficiency*; D000241:Adenosine / Q000378:metabolism; D000248:Adenosine Kinase / Q000172:deficiency*; D002460:Cell Line; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency; D007042:Hypoxanthines / Q000096:biosynthesis; D007288:Inosine / Q000494:pharmacology; D007292:Inosine Nucleotides / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D010430:Pentosyltransferases / Q000172:deficiency*; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D010770:Phosphotransferases / Q000172:deficiency*; D011687:Purines / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D007042:Hypoxanthines; D007292:Inosine Nucleotides; D011687:Purines; D007288:Inosine; D010754:Phosphoribosyl Pyrophosphate; D010430:Pentosyltransferases; D000228:Adenine Phosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase; D010770:Phosphotransferases; D000248:Adenosine Kinase; D000241:Adenosine