Human leukemic "null" cell line (NALL-1).
A human lymphoblast cell line, NALL-1, was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). NALL-1 cells had neither properties of T and B cells nor Epstein-Barr virus (EBV). Many characteristics of the NALL-1 line were distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. NALL-1 cells are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphologic and functional features. The NALL-1 line is the first human leukemic "null" cell line derived from ALL. The significance of this cell line is disscussed.
D001402:B-Lymphocytes / Q000473:pathology; D002460:Cell Line; D002877:Chromosomes, Human; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology