Production of hybrid cells by fusion of human malignant tumour cells and primary mouse embryo cells.
Hybrid cells with a subtetraploid mouse chromosome complement were produced by fusion of three types of human tumour cells with primary mouse embryo cells. The most frequently present presumptive human chromosome was 21. Numerous chromosome rearrangements were present. Some hybrid cells produced regressing tumours in mice.
D000230:Adenocarcinoma / Q000235:genetics / Q000276:immunology; D000818:Animals; D002459:Cell Fusion; D002460:Cell Line; D002875:Chromosomes; D003470:Culture Media; D005455:Fluorescent Antibody Technique; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure; D008545:Melanoma / Q000235:genetics / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA / Q000196:embryology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D010222:Parainfluenza Virus 1, Human; D012004:Rectal Neoplasms / Q000235:genetics / Q000276:immunology; D013964:Thyroid Neoplasms / Q000235:genetics / Q000276:immunology
D003470:Culture Media