Glial-mesenchymal tropism of in vivo avian sarcoma virus neuro-oncogenesis in rats.
Intracerebral inoculation of avian sarcoma virus (ASV) in postnatal animals induces gliomas and sarcomas but no neuronal tumors. High titer Bratislava-77 strain ASV was inoculated intracerebrally in fetal F-344 rats between 17 and 20 days of gestation: a time of active neuronal proliferation. Following birth inoculated rats developed gliomas and sarcomas but no neuronal tumors. The results are evidence that the glial-mesenchymal tropism of in vivo ASV neuro-oncogenesis is independent of stage of neurocytodifferentiation at inoculation.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D003238:Connective Tissue; D005260:Female; D005910:Glioma / Q000209:etiology; D009374:Neoplasms, Experimental / Q000209:etiology; D009457:Neuroglia; D011247:Pregnancy; D051381:Rats; D012509:Sarcoma / Q000209:etiology; D012513:Sarcoma, Experimental / Q000209:etiology