[Biokinetic behavior and metabolic effect of fructose in high dose continuous infusion in the rat].
The steady-state blood level of fructose during 24 hours intravenous infusion in response to different doses follows saturation kinetics. Even after toxic doses of 1.5 g/kg/h no depletion of liver adenine nucleotides can be observed after 24 hours. In the kidneys, however, ATP, ADP and total adenine nucleotides were decreased after a dose of 1.5 g/kg/h of fructose. The blood glucose increased continuously at infusion rates of 1.5 g/kg/h. Inorganic phosphate in the blood increased at doses of 1.0 and 1.5 g/kg/h. The weight of the kidneys increased, presumably through water uptake. Urinary secretion was drastically reduced at doses above 1.0 g/kg/h. An appreciable activity of ketohexokinase can be demonstrated in the kidneys.
D000244:Adenosine Diphosphate / Q000032:analysis; D000249:Adenosine Monophosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005632:Fructose / Q000378:metabolism; D007263:Infusions, Parenteral; D007668:Kidney / Q000032:analysis; D007773:Lactates / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D010710:Phosphates / Q000097:blood; D010770:Phosphotransferases / Q000032:analysis; D011773:Pyruvates / Q000032:analysis; D051381:Rats
D001786:Blood Glucose; D007773:Lactates; D010710:Phosphates; D011773:Pyruvates; D005632:Fructose; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010770:Phosphotransferases
Biokinetisches Verhalten und Stoffwechselwirkungen von Fructose bei hochdosierter Dauerinfusion an der Ratte