title: Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives.
abstract: A case of hepatocellular carcinoma in a young female is presented in which the apparent etiology was the use of oral contraceptives for 5 1/2 years. Sequential therapeutic trials with intraarterial 5-fluorouracil, intraarterial adriamycin, and intravenous 1,3 bis[2-chloroethyl]-1-nitrosourea (BCNU) were unsuccesful. The adverse effects of oral contraceptives on the structure and function of hepatic tissue are reviewed.
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D002330:Carmustine / Q000627:therapeutic use; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D008656:Mestranol / Q000009:adverse effects*; D009640:Norethindrone / Q000009:adverse effects*
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004317:Doxorubicin; D008656:Mestranol; D009640:Norethindrone; D005472:Fluorouracil; D002330:Carmustine