title: Anterior horn cell degeneration and Bunina-type inclusions associated with dementia.
abstract: The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000473:pathology*; D000870:Anterior Horn Cells / Q000473:pathology*; D001706:Biopsy; D003704:Dementia / Q000150:complications / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies; D008566:Membranes; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria; D009046:Motor Neurons / Q000473:pathology*