Interaction of Pt(II) complexes with DNAs from various sources. A circular dichroism study.
The interaction of cis- and trans-Pt(NH3)2Cl2 with DNAs of different base composition was studied by means of circular dichroism (CD) spectroscopy. The spectra obtained indicated a partial transformation of the secondary structure of DNA (B- less than C transition) with an increased helix winding. Subtle differences were noted between the two isomers, possibly related to changes in base orientation due to the different molecular geometries of the P+(II) complexes.
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D002945:Cisplatin / Q000032:analysis / Q000138:chemical synthesis; D003016:Clostridium perfringens; D004247:DNA / Q000032:analysis; D007536:Isomerism; D008837:Micrococcus; D012701:Serotonin; D013950:Thymus Gland
D012701:Serotonin; D004247:DNA; D002945:Cisplatin