The genetic mapping of a defective LPS response gene in C3H/HeJ mice.
The expression of a defective LPS response gene Lps and the major urinary protein (Mup-1) are concordantly inherited in backcross (C3H/HeJ x C57BL/6J)F1 x C3H/HeJ mice, indicating genetic linkage of these loci. Mup-1 is known to be linked to the brown coat color locus on chromosome 4 in mice; thus Lps can now be assigned to chromosome 4. A value of 0.06 +/- 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci.
D000818:Animals; D002874:Chromosome Mapping; D004926:Escherichia coli / Q000276:immunology; D005802:Genes, MHC Class II; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D011135:Polysaccharides, Bacterial; D011507:Proteinuria / Q000235:genetics; D013576:Syndactyly / Q000235:genetics
D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial