Hyperkalemia due to selective hypoaldosteronism.
Hyperkalemia secondary to hyporeninemic hypoaldosteronism with a normal glucocorticoid function was diagnosed in a 47-year-old man with moderate renal insufficiency. Mineralocorticoid administration corrected the hyperkalemia. A probable explanation for hyporeninemia and hypoaldosteronism in this syndrome is that the primary defect is an inability to release renin and the resultant angiotensin deficiency leads to an aldosterone deficiency.
D000138:Acidosis / Q000150:complications; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000450:Aldosterone / Q000172:deficiency* / Q000378:metabolism; D000804:Angiotensin II / Q000172:deficiency; D002712:Chlorides / Q000097:blood; D006801:Humans; D006947:Hyperkalemia / Q000150:complications / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D002712:Chlorides; D000804:Angiotensin II; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin