Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor.
ACTH was purified from thymic tumor associated with ectopic ACTH production by gel filtration and ion exchange chromatography. Amino acid composition and C- and N-terminal analyses indicated that this tumor ACTH was comprised of the 2-38 sequence of authentic pituitary ACTH. The observations suggest that the mode of cleavage of this tumor ACTH from its precursor is different from that of pituitary ACTH.
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000302:isolation & purification; D000596:Amino Acids / Q000032:analysis; D002276:Carcinoid Tumor / Q000378:metabolism*; D006801:Humans; D009928:Organ Specificity; D010902:Pituitary Gland / Q000378:metabolism; D013953:Thymus Neoplasms / Q000378:metabolism*
D000596:Amino Acids; D000324:Adrenocorticotropic Hormone