Cyclic adenosine 3',5'-monophosphate and leucocyte chemotaxis in vivo.
1 The effect of local elevation of leucocyte cyclic adenosine 3',5'-monophosphate (cyclic AMP) content on the continued migration of leucocytes to a site of acute inflammation was studied in the pleural cavity of rats. 2 Leucocyte cyclic AMP levels were elevated by injecting with the irritant into the pleural cavity dibutyryl cyclic AMP alone or with theophylline. 3 The treatments both produced a marked reduction in leucocyte migration into a pleural reaction induced by immediate hypersensitivity, but had no effect on cell numbers in pleurisy induced either by pyrophosphate or urate crystals.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte; D000242:Cyclic AMP / Q000097:blood / Q000502:physiology*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010998:Pleurisy / Q000503:physiopathology; D051381:Rats; D013806:Theophylline / Q000494:pharmacology
D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP