Changes in plasma lipoproteins in subjects treated with the bile acid-sequestering resin polidexide (Secholex).
The effects of a new anion-exchange resin, polidexide, 3-30 grams/day, on plasma lipids and lipoproteins have been studied in one normal subject and in three hyperlipidaemic patients. Plasma cholesterol concentrations were significantly reduced in all subjects over 80-120 days of therapy by amounts ranging from 14 to 20%. Plasma triglyceride concentrations increased in two patients with pre-existing hypertriglyceridaemia. Plasma apolipoprotein-B concentrations were reduced in all subjects. Cholesterol and apo-B concentrations in low density lipoproteins were reduced in all subjects, while triglyceride concentrations in very low density lipoproteins were increased in 3/4 subjects; Changes in high density lipoproteins were quite variable.
D000328:Adult; D000837:Anion Exchange Resins / Q000627:therapeutic use*; D001059:Apoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood
D000837:Anion Exchange Resins; D001059:Apoproteins; D007475:Ion Exchange Resins; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002792:Cholestyramine Resin; D002784:Cholesterol