title: Intracellular collagen fibrils in prolapsed ("floppy") human atrioventricular valves.
abstract: Ultrastructural study of prolapsed atrioventricular valves from five patients, one of whom also had the Marfan syndrome, disclosed granular cells that were characterized by numerous membrane-bound, electron-dense inclusions resembling those in the Hurler syndrome. Collagen fibrils were present within some of these inclusions. The intracellular collagen deposits may form as a consequence of abnormal interactions between newly secreted collagen and acid mucopolysaccharides.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003094:Collagen; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D008382:Marfan Syndrome / Q000473:pathology; D008875:Middle Aged; D008943:Mitral Valve / Q000648:ultrastructure*; D008944:Mitral Valve Insufficiency / Q000473:pathology*; D011391:Prolapse; D014261:Tricuspid Valve / Q000648:ultrastructure*; D014262:Tricuspid Valve Insufficiency / Q000473:pathology*
chemical_list: D003094:Collagen