[Effect of adrenoreceptor blockaders on the mitotic activity of regenerating liver].
One hour before resection of the liver and repeatedly 24 hours after the operation male rats were given phentholamine--a blocker of alpha-adrenoceptors; this preparation inhibited the mitotic activity of the regenerating liver. A double administration at the same periods of propanol--a blocker of beta-adrenoceptors--caused an elevation of the mitotic activity. A conclusion was drawn that by stimulation of beta-adrenoceptors it was possible to inhibit the regenerative process. Adrenaline stimulated this process by acting through beta-adrenoceptors.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D004247:DNA; D011433:Propranolol; D000242:Cyclic AMP; D010646:Phentolamine
Vliianie blokatorov adrenoretseptorov na mitoticheskuiu aktivnost' regeneriruiushcheĭ pecheni