Human colon tumors: enzymic and histological characteristics.
In samples of colonic adenocarcinomas, the mean activities of thymidine kinase, glucose-6-phosphate dehydrogenase, phosphoserine phosphatase and pyrroline-5-carboxylate reductase were several fold higher than those of nonneoplastic colon. The presence of considerable, cold labile pyrroline-5-carboxylate reductase activity provided an additional criterion for distinguishing tumors from the control tissue. Deviations from the pattern of enzymes in normal colon were much more pronounced in the five moderately well-differentiated than in the single well-differentiated adenocarcinoma.
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000473:pathology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D009943:Organophosphorus Compounds; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011762:Pyrroline Carboxylate Reductases / Q000378:metabolism; D012694:Serine; D013937:Thymidine Kinase / Q000378:metabolism
D009943:Organophosphorus Compounds; D012694:Serine; D005954:Glucosephosphate Dehydrogenase; D011762:Pyrroline Carboxylate Reductases; D013937:Thymidine Kinase; D010744:Phosphoric Monoester Hydrolases; C022394:phosphoserine phosphatase