Effect of estrogens on apomorphine-induced circling behavior in the rat.
The effect of administration of estrogens parenterally for 1 week was tested on apomorphine-induced circling in a group of castrated female rats with a lesion of the left entopednucluar nucleus. We observed a significant decrease in the number of turns per minute in estrogen-treated animals as compared with controls. Our tentative explanation is that estrogens decrease the sensitivity of dopamine receptors in the striatum.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D001519:Behavior / Q000187:drug effects*; D002369:Castration; D003342:Corpus Striatum / Q000502:physiology; D004967:Estrogens / Q000494:pharmacology*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D005260:Female; D005917:Globus Pallidus / Q000502:physiology; D006801:Humans; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D001058:Apomorphine