[The effect of curare-like agents on synaptic transmission in the spinal cord].
In experiments with decerebrated cats subject to study was the influence of new curare-like agents of non-depolarized type of action, such as diadonium, decadonium, RGH-1106, pancuronium-bromide (pavulon) and also of paramion and mellictine on the magnitude of mono-and polysynaptic potentials of the spinal cord, the time of synaptic delay, the lability of the spinal centres and cycle of the motoneurons excitability restoration. Diadonium, decadonium, RGH-1106 and pavulon when used in 1--5-fold myoparalytic doses did not affect the bioelectric activity of the spinal cord. Mellictinum (3,5--4,5 mg/kg)) produced a rise of the monosynaptic responses amplitude by 21 per cent through inhibition of the Renshow n-cholinoreceptors cells. Paramion (0.3--1 mg/kg) suppressed monosynaptic potentials, increasing the afferent proprioceptic activity.
D000818:Animals; D002415:Cats; D003655:Decerebrate State; D005071:Evoked Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D012023:Reflex, Monosynaptic / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D003473:Neuromuscular Nondepolarizing Agents
O Vliianii kurarepodobnykh sredstv na sinapticheskuiu peredachu v spinnom mozge.