Growth inhibition of transformed cells with succinylated concanavalin A.
Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G1 phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.
D002448:Cell Adhesion / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003208:Concanavalin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D013539:Simian virus 40; D013386:Succinates
D013386:Succinates; D003208:Concanavalin A