Drug tolerance in biomembranes: a spin label study of the effects of ethanol.
Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.
D000222:Adaptation, Physiological; D000818:Animals; D004361:Drug Tolerance; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008566:Membranes / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008811:Mice, Inbred DBA; D008928:Mitochondria / Q000187:drug effects; D009186:Myelin Sheath / Q000187:drug effects; D013113:Spin Labels; D013574:Synaptosomes / Q000187:drug effects
D013113:Spin Labels; D000431:Ethanol