Formation of P1, P2-dinucleoside 5'-pyrophosphates under potentially prebiological conditions.
Organic pyrophosphates such as UppA and NAD are formed when a solution containing a nucleotide, a nucleoside 5'-polyphosphate, Mg2+ and imidazole are allowed to dry out. We suggest that this synthesis may have occured concurrently with oligonucleotide formation.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000255:Adenosine Triphosphate; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles; D008274:Magnesium; D009243:NAD / Q000138:chemical synthesis*; D009537:Nicotinamide Mononucleotide; D014500:Uracil Nucleotides / Q000138:chemical synthesis*; D014530:Uridine Diphosphate / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D014542:Uridine Monophosphate
D007093:Imidazoles; D014500:Uracil Nucleotides; D009243:NAD; D009537:Nicotinamide Mononucleotide; D014530:Uridine Diphosphate; D000255:Adenosine Triphosphate; D014542:Uridine Monophosphate; D008274:Magnesium; D000241:Adenosine