Regional mapping on human genes for phosphoglucomutase-1 on chromosome 1 and beta-glucuronidase on chromosome 7 using mouse x human hybrids.
Two independent mouse-human somatic cell hybrid clones contained different, de novo chromosome rearrangements involving the short arm of human chromosome 1. One hybrid clone contained a translocation between human chromosomes 1 and 7; the other clone contained a rearrangement product between human chromosomes 1 and 14. Analysis of these clones for expression of genes previously assigned to chromosome 7 and to the short arm of chromosome 1 provided evidence for localization of PGM--1 in segment 1p22.1 leads to 1p31.1, AK--2, ENO--1 and UMPK in region 1pter leads to 1p31.1, and GUS in region 7 pter leads to 7q22. The results have been used to examine the relationship between cytologic and genetic map distances on the short arm of chromosome 1.
D000263:Adenylate Kinase / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells; D005796:Genes; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure*; D007962:Leukocytes / Q000648:ultrastructure; D051379:Mice; D009703:Nucleoside-Phosphate Kinase / Q000235:genetics; D010733:Phosphoglucomutase / Q000235:genetics*; D010751:Phosphopyruvate Hydratase / Q000235:genetics; D014178:Translocation, Genetic; D014542:Uridine Monophosphate
D014542:Uridine Monophosphate; D000263:Adenylate Kinase; D009703:Nucleoside-Phosphate Kinase; D005966:Glucuronidase; D010751:Phosphopyruvate Hydratase; D010733:Phosphoglucomutase