11,12-secoprostaglandins. 4. 7-(N-alkylmethanesulfonamido) heptanoic acids.
A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D006538:Heptanoic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006538:Heptanoic Acids; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D000242:Cyclic AMP