title: [Use of inactivated vaccine against infectious rhinotracheitis--pustular vulvovaginitis (IBR-IPV) in calves and pregnant cows].
abstract: A total of twelve batches of an inactivated vaccine against IBR--IPV, obtained by the authors, were tested in the practice. Vaccinated were 212 calves and 1172 cows and heifers on five dairy farms in different communities. On the basis of virologic, serologic, clinical and epizootiologic investigations the conclusions were drawn that the vaccine is harmless and highly immunogenic. In subcutaneous application at the rate of 3 cm3, twice, it renders protection against IBR--IPV infection (respiratory diseases and abortions) to calves aged more than 30 days for at least 6 months and 8 months for pregnant cows and heifers. On farms with a record of active IBP--IPV infection it is suggested to treat both the diseased and apparently (clinically) normal calves, either therapeutically or prophylactically, with a hyperimmune serum, and after the disease has receded--to resort to vaccination. In comparison with the live vaccines the tested one has been shown to provoke no postvaccinal accidents, eliminating the possibility of maintaining and widening the active infection foci, at otherwise almost comparable immunogenic properties as regards the titers of the virus-neutralizing antibodies produced after the vaccination.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D007109:Immunity / Q000187:drug effects; D007117:Immunization, Secondary / Q000662:veterinary; D007241:Infectious Bovine Rhinotracheitis / Q000276:immunology / Q000517:prevention & control*; D011247:Pregnancy; D013997:Time Factors; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines
vernacular_title: Prilozhenie na inaktivirana vaksina sreshtu infektsiozniia rinotrakheit-pustulozniia vulvovaginit (IBR-IPV) na teleta i bremenni kravi.