title: The signal from fruiting body and conus tips of Dictyostelium discoideum.
abstract: Tips from fruiting bodies and conuses were transplanted into interphase fields of Dictyostelium discoideum amoebae. Progressively increasing concentrations of beef-heart phosphodiesterase added to the fields significantly decreased the chemotactic range of the responding amoebae. The findings suggest that the tip secretes c-AMP. We also find that the chemotactic range is independent of the size of the tip implying that the tip may produce a regulating gradient.
mesh_terms: D000818:Animals; D002465:Cell Movement; D002633:Chemotaxis / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000254:growth & development*; D009235:Myxomycetes / Q000254:growth & development*; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases