title: [Enzymomorphology of the vaccinal process in connection with formation of immunity to plague].
abstract: The studies conducted showed that the beginning of immunogenesis following the administration of live plague vaccine was preceded by a period of primary toxic action of multiplying microbes when the activity of a number of enzymes in the organs of guinea-pigs was temporarily reduced. Subsequently, inductive and productive phases of formation of antibodies started against the background of normalization and growth of the enzymatic activity associated with mobilization of energy. The earliest hyperplastic changes during immunogenesis occurred in the thymus-dependent areas of the lymphoid organs. Somewhat later, hyperplasia of B-structures dependent on the bone marrow started to prevail.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000251:Adenosine Triphosphatases / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D003576:Electron Transport Complex IV / Q000032:analysis; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D006168:Guinea Pigs; D008221:Lymphoid Tissue / Q000473:pathology; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis; D010734:Phosphogluconate Dehydrogenase / Q000032:analysis; D010930:Plague / Q000276:immunology*; D010931:Plague Vaccine / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000032:analysis; D015010:Yersinia pestis / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D010931:Plague Vaccine; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases; D003576:Electron Transport Complex IV; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases
vernacular_title: Enzimomorfologiia vaktsinal'nogo protsessa v sviazi s formirovaniem immuniteta k chume