[The action of silymarin on Galactosamine-induced hepatitis in the rat (author's transl)].
The hepatoprotective action of Silymarin was studied in 65 male Wistar rats, prior to and following D-galactosamine intoxication. There was a marked reduction in the histological and ultrastructural changes in the nucleolus, nuclear membrane, mitochondria, granular and agranular endoplasmic reticulum and lysosomes of the liver cell and also in the Kupffer stellate cells. The reduction in glycogen and RNA loss was determined biochemically. The activities of many enzymes were kept constant (oxidoreductases, NADH2 diaphorase, G-6-phosphatase, Mg++ and K+/Na+-dependent ATPases, acid phosphatases).
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004341:Drug Evaluation; D005419:Flavonoids / Q000627:therapeutic use*; D005688:Galactosamine; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000648:ultrastructure; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D009696:Nucleic Acids / Q000032:analysis; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use*
D005419:Flavonoids; D008112:Liver Glycogen; D009696:Nucleic Acids; D012838:Silymarin; D005688:Galactosamine; D010088:Oxidoreductases; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase; D000251:Adenosine Triphosphatases
Die Wirkung von Silymarin auf die experimentelle Galaktosamin-Hepatitis bei der Ratte