Interaction between ACTH fragments, brain opiate receptors and morphine-induced analgesia.
The present study confirms that N-terminal fragments of ACTH have an affinity for rat brain opiate receptors in vitro. Such peptides, devoid of corticotrophic activity, were found to inhibit morphine-induced analgesia if they also possessed affinity for opiate receptors in vitro. The structure-activity relationship for these two parameters is comparable to that observed for the same peptides on the induction of excessive grooming.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000698:Analgesia; D000818:Animals; D001921:Brain / Q000187:drug effects*; D005260:Female; D009020:Morphine / Q000037:antagonists & inhibitors*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; D011957:Receptors, Opioid; D009020:Morphine; D000324:Adrenocorticotropic Hormone