Adjuvant polyarthritis. III. Evidence in support of viral etiology.
Intraperitoneal administration of a relatively small volume (0.2 ml) of plasma obtained from Sindbis virus--infected animals containing approximately 480 units of interferon/ml effectively suppressed the development of adjuvant arthritis. Similarly, administration of interferon (624 units/rat/day, ip) prepared in vitro by exposing rat embryo fibroblast culture to poly I:C in the presence of cycloheximide also suppressed the development of adjuvant arthritis without affecting the humoral or the cell-mediated immune response. The findings provide circumstantial evidence to the speculation that a virus or a virus-like organism plays a role in the pathogenesis of this disease.
D000818:Animals; D000917:Antibody Formation; D001168:Arthritis / Q000209:etiology*; D001169:Arthritis, Experimental / Q000209:etiology* / Q000276:immunology; D003513:Cycloheximide / Q000494:pharmacology; D007111:Immunity, Cellular; D007372:Interferons; D008297:Male; D011070:Poly I-C / Q000494:pharmacology; D051381:Rats; D012845:Sindbis Virus; D012897:Slow Virus Diseases / Q000150:complications; D013994:Tilorone / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000150:complications*
D007372:Interferons; D003513:Cycloheximide; D013994:Tilorone; D011070:Poly I-C