The passage of apoproteins from plasma lipoproteins into the lipoproteins of peripheral lymph in man.
1. The transport of apoprotein B from the lipoprotein of plasma into the lipoproteins of lymph draining the foot has been studied in four men with type III hyperlipoproteinaemia. 2. Three subjects were given autologous 125I-labelled very-low-density lipoprotein (VLDL) and 131I-labelled low-density lipoprotein (LDL) by intravenous injection; the fourth was given autologous 125I-labelled VLDL and 131I-labelled intermediate-density lipoprotein (IDL) plus LDL. 3. The 125I/131I ratios in serum and lymph apoprotein B, and the 125I and 131I specific radioactivities of apoprotein B in VLDL, IDL and LDL from serum and lymph, indicate that apoprotein B in the circulating VLDL can reach peripherallymph without the intermediacy of circulating LDL.
D000328:Adult; D001059:Apoproteins / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008196:Lymph / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D001059:Apoproteins; D008074:Lipoproteins; D008079:Lipoproteins, VLDL