Transmission of hormonal stimulation by cell-to-cell communication.
Rat ovarian granulosa cells and mouse myocardial cells respond to cell-specific hormones by cyclic AMP-dependent mechanisms. In coculture, these heterologous cells communicate by means of gap junctions. Exposure of the cocultures to a hormone specific for one cell type causes the heterologous cells to respond through a cell contact-dependent mechanism. These studies suggest that this cross-stimulation results from the intercellular communication of a mediator that is common to both cell types. The communicated mediator may be cyclic AMP.
D002450:Cell Communication; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006107:Granulosa Cells / Q000378:metabolism; D007365:Intercellular Junctions / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D010960:Plasminogen Activators / Q000378:metabolism
D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D010960:Plasminogen Activators; D009638:Norepinephrine