Evaluation of radiopharmaceuticals for the detection of acute myocardial infarction in man.
The accuracy of the scintigraphic diagnosis of acute myocardial infarction with 99mTc-pyrophosphate, 99mTc-tetracycline and 99mTc-glucoheptonate was assessed in 63 patients, 43 of whom had clinical evidence of acute myocardial infarction. In 15, studies with both 99mTc-tetracycline and 99mTc-pyrophosphate were performed. Accuracy was greatest with 99mTc-pyrophosphate (17/17 true positives, 8/10 true negatives) contrasted with 99mTc-tetracycline (12/25 true positives, 6/11 true negatives) and 99mTc-glucoheptonate (3/13 true positives, 2/2 true negatives). 99mTc-pyrophosphate was the most sensitive tracer for the detection of acute myocardial infarction. The diagnostic accuracy with 99mTc-glucoheptonate was poor.
D000208:Acute Disease; D003951:Diagnostic Errors; D011756:Diphosphates; D005069:Evaluation Studies as Topic; D006539:Heptoses; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013400:Sugar Acids; D013667:Technetium; D013752:Tetracycline
D011756:Diphosphates; D006539:Heptoses; D011868:Radioisotopes; D013400:Sugar Acids; D013667:Technetium; D013752:Tetracycline