Inhibitors of hypoxanthine metabolism in Ehrlich ascites tumor cells in vitro.
One hundred and sixty-one purine analogs and derivatives were tested for their ability to inhibit ten parameters of purine metabolism in Ehrlich ascites tumor cells incubated in vitro with radioactive hypoxanthine. Sixty-seven compounds were inhibitory against at least one parameter and 30 were inhibitory against two or more.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005973:Glutamine; D006150:Guanine Nucleotides; D006160:Guanosine Triphosphate / Q000378:metabolism; D007041:Hypoxanthine Phosphoribosyltransferase / Q000037:antagonists & inhibitors; D007042:Hypoxanthines / Q000378:metabolism*; D066298:In Vitro Techniques; D007292:Inosine Nucleotides; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors; D008025:Ligases / Q000037:antagonists & inhibitors; D008190:Lyases / Q000037:antagonists & inhibitors; D051379:Mice; D011687:Purines / Q000494:pharmacology*
D006150:Guanine Nucleotides; D007042:Hypoxanthines; D007292:Inosine Nucleotides; D011687:Purines; D005973:Glutamine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D007658:Ketone Oxidoreductases; D007041:Hypoxanthine Phosphoribosyltransferase; D008190:Lyases; D008025:Ligases; D006152:Cyclic GMP