Small virus particles in faeces of patients with infectious hepatitis (hepatitis A).
Forty-one faecal samples from infectious-hepatitis patients and their contacts were investigated for the presence of hepatitis-A-associated viral particles. Of these, 16 gave a positive result by immune electronmicroscopy or caesium-chloride density-gradient centrifugation. The latter method proved invaluable in detecting small numbers of virus particles. The particles found had buoyant density of 1-34-1-35 and a size range of 21-28 nm. Epidemiological evidence suggested that they might be the causative agent of hepatitis A.
D000956:Antigens, Viral / Q000032:analysis; D002499:Centrifugation, Density Gradient; D003090:Coliphages / Q000648:ultrastructure; D003429:Cross Reactions; D029822:Enterovirus B, Human / Q000648:ultrastructure; D005243:Feces / Q000382:microbiology*; D005260:Female; D006506:Hepatitis A / Q000382:microbiology*; D006507:Hepatovirus / Q000276:immunology / Q000302:isolation & purification / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron
D000956:Antigens, Viral