title: The alternate respiratory pathway of Candida albicans.
abstract: Candida albicans contains a cryptic cyanide and antimycin A insensitive respiratory system. This alternate oxidase was found (i) at all growth rates from mu = 0.05 to 0.26 in a chemostat culture and (ii) in both mycelial and yeast forms of the organism. Neither chloramphenicol nor cycloheximide prevented the expression of the alternate oxidase. Salicylhydroxamic acid was a potent inhibitor of the cyanide insensitive respiration. The respiration of mitochondria grown in the presence of antimycin A was not inhibited by cyanide or antimycin A but was inhibited by salicylhydroxamic acid.
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D000968:Antimycin A / Q000494:pharmacology; D001386:Azides / Q000494:pharmacology; D002176:Candida albicans / Q000378:metabolism*; D002701:Chloramphenicol / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003576:Electron Transport Complex IV / Q000378:metabolism; D006877:Hydroxamic Acids / Q000494:pharmacology; D008928:Mitochondria / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D012457:Salicylamides / Q000494:pharmacology; D013104:Spheroplasts / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D001386:Azides; D003486:Cyanides; D006877:Hydroxamic Acids; D012457:Salicylamides; D000968:Antimycin A; D002701:Chloramphenicol; C005703:salicylhydroxamic acid; D003513:Cycloheximide; D010088:Oxidoreductases; D003576:Electron Transport Complex IV