[Study of the role of endogenous 3',5'-cyclic AMP in the radioresistance of the cell].
A survival period of irradiated rat thymocytes was studied after administration of several possible modifiers of intracellular 3',5'-cyclo AMP. Theophylline, which inhibits 3',5'-cyclo AMP phosphodiesterase, adrenaline, ATP and adenosine possessed a radioprotective effect if they were added before the irradiation or just immediately after it. Imidazole activated 3',5'-cyclo AMP phosphodiesterase and, being added within the above-mentioned periods, it shortened the survival period at the irradiated cells. When theophylline and imidazole were added within 30 min after the irradiation, their effect was completely altered: imidazole increased but theophylline decreased the survival period of the irradiated cells. 3',5'-cyclo AMP and N6-2'-0-dibutyryl-3',5'-cyclo AMP did not affect the viability of thymocytes after the irradiation.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002477:Cells / Q000528:radiation effects*; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D011836:Radiation Tolerance; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors
D007093:Imidazoles; D000255:Adenosine Triphosphate; D013806:Theophylline; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000241:Adenosine; D004837:Epinephrine
Izuchenie roli éngogennogo 3',5'-TsAMP v radiorezistentnosti kletki