The effect of psychotropic drugs on the TSH-response to thyroliberin (TRH).
The effect of chlorpromazine (CPZ), thioridazine (TR), L-dopa, fusaric acid (FA), pimozide (PZ) and propranolol (P) in the i.v. thyrotropin-releasing hormone (TRH) stimulation test was studied in 75 subjects. It was found that chronic treatment with CPZ, TR and L-dopa inhibits the response to TRH. FA may to some extent counteract the effect of L-dopa. The results indicate that the response of the pituitary to TRH as regards the secretion of TSH is mainly regulated by norepinephrinergic alpha-receptors.
D002746:Chlorpromazine / Q000494:pharmacology; D005669:Fusaric Acid / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010868:Pimozide / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013881:Thioridazine / Q000494:pharmacology; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D011619:Psychotropic Drugs; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D010868:Pimozide; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D011433:Propranolol; D005669:Fusaric Acid; D013881:Thioridazine; D002746:Chlorpromazine; D009638:Norepinephrine