Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections.
Polymyxin B and rifampin were given to 12 patients with multi-drug-resistant nosocomial Serratia marcescens infections. Eight cures were achieved; drug hepatotoxicity occurred once; one fatal suprainfection was encountered; and two patients died during therapy of causes related to severe underlying illnesses. Polymyxin B and rifampin were uniformly synergistic in vitro against the infecting strains and against 40 additional clinical isolates of S. marcescens.
D000328:Adult; D000368:Aged; D004352:Drug Resistance, Microbial; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000008:administration & dosage* / Q000494:pharmacology; D011113:Polymyxins / Q000008:administration & dosage*; D012293:Rifampin / Q000008:administration & dosage* / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects
D011113:Polymyxins; D011112:Polymyxin B; D012293:Rifampin