Lysosomal enzyme secretion in rat ventral prostate. Secretagogue action of testosterone and dibutyryl cyclic AMP.
Rat ventral prostate slices, when incubated in vitro, secrete protein, lysosomal enzymes and newly phosphorylated components in a time- and temperature-dependent manner. Testosterone and dibutyryl cyclic AMP immediately stimulate secretion and 32Pi incorporation. Acid phosphatase and beta-N-acetylhexosaminidase are secreted as acidic isoenzymes presumably contained within primary lysosomes.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D003994:Bucladesine / Q000494:pharmacology*; D006596:Hexosaminidases / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D007700:Kinetics; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010766:Phosphorylation; D011467:Prostate / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D003994:Bucladesine; D006867:Hydrolases; D000135:Acid Phosphatase; D001192:Arylsulfatases; D006596:Hexosaminidases