title: Vaccination of cattle and sheep with a combined Clostridium perfringens types C and D toxoid.
abstract: Cattle and sheep (30 each) were vaccinated with a combined Clostridium perfringens type C and C perfringens type D toxoid. Vaccination and blood sample collections were made every 2 weeks over a period of 8 weeks. Increases in antitoxin titers occurred after the 2nd administration of the 2.0-ml combined product. Highest titers were recorded when the 2nd vaccinal dose was given 2 weeks after the first. This confirms reports that response to clostridial antigens is greater when the 2nd immunizing dose is delayed 2 to 6 weeks after the initial dose.
mesh_terms: D000818:Animals; D000992:Antitoxins / Q000032:analysis; D002417:Cattle / Q000276:immunology*; D003016:Clostridium perfringens / Q000276:immunology*; D007279:Injections, Subcutaneous; D012756:Sheep / Q000276:immunology*; D014121:Toxoids / Q000008:administration & dosage; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000992:Antitoxins; D014121:Toxoids