Profile of beta-adrenoceptors in femoral, superior mesenteric and renal vascular beds of dogs.
1. The homogeneity of beta-adrenoceptors in femoral, superior mesenteric and renal vascular beds was investigated by the use of the regional perfusion technique in dogs. 2. Isoprenaline and salbutamol produced dose-related increases in femoral and superior mesenteric blood flow. The dose-response curves for the two agonists were parallel, but salbutamol was approximately 1/15 as potent as isoprenaline on a weight basis. 3. Isoprenaline and salbutamol increased renal blood flow in a dose-related manner. However, salbutamol was approximately 1/240 as potent as isoprenaline on a weight basis, and the slope of the dose-response curve for salbutamol was less steep than that for isoprenaline. 4. The dose-response curves to isoprenaline for increase in femoral and superior mesenteric blood flow were shifted to the right by intravenous pindolol but not by intravenous or intra-arterial practolol. 5. The dose-response curves to isoprenaline for increase in renal blood flow were shifted to the right more markedly by intravenous pindolol than by intravenous or intra-arterial practolol. 6. The results indicate that beta-adrenoceptors of the renal vascular bed consist of beta1-type and beta2-type whereas the femoral and superior mesenteric vascular beds contain only beta2-adrenoceptors.
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000098:blood supply*; D007545:Isoproterenol / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008643:Mesentery / Q000098:blood supply*; D010869:Pindolol / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D010869:Pindolol; D007545:Isoproterenol; D000420:Albuterol; D011217:Practolol