Toxicological evaluations of some brominated biphenyls.
Extensive toxicological studies were carried out to define the probable hazard of octabromobiphenyl (OBB) to workers, users, and the environment. OBB had low acute toxicity in mammals and birds by various routes of administration. It was essentially non-irritating to rabbit eyes, non-irritating to human skin and caused only mild skin irritation and no sensitization in the guinea pig. OBB caused equivocal effects in the rat fetus. OBB was stored in the body fat of rats and caused liver enlargement at high single doses or low repeated doses. The studies indicate probable low safety factors in application and use and probable bioaccumulation. Hexabromobiphenyl (HBB) was more acutely toxic than OBB by skin absorption in the rabbit and caused liver enlargement at lower single doses.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D001835:Body Weight; D003877:Dermatitis, Contact / Q000209:etiology; D004032:Diet; D004781:Environmental Exposure; D005123:Eye / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006168:Guinea Pigs; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size; D011075:Polybrominated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D011784:Quail; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption
D001713:Biphenyl Compounds; D011075:Polybrominated Biphenyls; C011048:octabromobiphenyl