Inhibition of herpes simplex virus multiplication by 2,3-bis(acetyl mercaptomethyl)-quinoxalin.
The drug 2,3-bis(acetyl mercaptomethyl)-quinoxalin (BAMMQ) was 99.9% inhibitory for herpes simplex virus (HSV) multiplication in cell cultures at concentrations of 1.6 X 10(-5) M or less. The drug was not inactivating for the virus, did not interfere with adsorption and penetration of the virus, and was still active when added as late as 12 h after infection with HSV. BAMMQ did not prevent HSV DNA replication, but interfered with a late stage of virus assembly and/or maturation.
D002460:Cell Line; D003470:Culture Media; D004279:DNA, Viral / Q000096:biosynthesis; D011810:Quinoxalines / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D003470:Culture Media; D004279:DNA, Viral; D011810:Quinoxalines; D013936:Thymidine