[Alteration of the catecholamine receptor during hepatic malignancy (author's transl)].
The adenylate cyclase system of a plasma membrane preparation from normal rat liver responds to various catecholamines in the following order: protokylol greater than isoproterenol greater than epinephrine greater than norepinephrine. In the Zadejela ascites hepatoma, the order of sensitivity is modified, indicating a transformation of the receptor from the beta2 to the beta1 type. These observations suggest that the catecholamine receptor might be a single entity, susceptible to secondary, and reversible, modification towards either a beta 1 or a beta 2 type.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism*; D009374:Neoplasms, Experimental; D051381:Rats; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta
D002395:Catecholamines; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta
Modification du récepteur hépatique des catécholamines après transformation maligne