Genetic determination of the alpha-galactosidase developmental program in mice.
The expression of alpha-galactosidase in liver, heart, and brain during postembryonic development has been examined in several inbred mouse strains. In most strains, the developmental patterns of alpha-galactosidase are coordinate with those of two other acid hydrolases, beta-glucuronidase and beta-galactosidase. Certain inbred mouse strains, including members of the C57-C58 family, have a tissue-specific alteration in the temporal expression of alpha-galactosidase activity. This alteration shows additive inheritance and appears to be controlled by a single genetic locus. The altered developmental expression of the enzyme is not accompanied by any discernible change in its physical properties.
D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D005696:Galactosidases / Q000378:metabolism*; D005796:Genes; D006321:Heart / Q000254:growth & development; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D008247:Lysosomes / Q000201:enzymology*; D046911:Macromolecular Substances; D051379:Mice; D008815:Mice, Inbred Strains / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D000519:alpha-Galactosidase / Q000235:genetics / Q000378:metabolism*
D046911:Macromolecular Substances; D005696:Galactosidases; D000519:alpha-Galactosidase