Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus).
Owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with JC, BK, or SV40 virus. Two of four adult owl monkeys inoculated with JC virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. A grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. The second monkey developed a malignant tumor in the left cerebral hemisphere containing both glial and neuronal cell types. Impression smears prepared from unfixed tissue of this tumor showed cells that contained polyomavirus T antigen. Virion antigens were not detected. Tumor cells cultured in vitro also contained T antigen but were negative for virion antigen. Infectious virus was not isolated from extracts of this tumor.
D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D007165:Immunosuppression Therapy; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D011120:Polyomavirus / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral