Effect of concomitant administration of magnesium trisilicate on GI absorption of dexamethasone in humans.
The oral absorption of dexamethasone in humans was compared to its absorption when coadministered with magnesium trisilicate. The bioavailability of dexamethasone was estimated by measuring the suppressive effect of the drug on the daily excretion of endogenous steroids. Administration of 1 mg of dexamethasone to six healthy male volunteers significantly decreased the urinary excretion of 11-hydroxycorticosteroids. However, the coadministration of magnesium trisilicate with dexamethasone decreased its absorption, as indicated by the increased urinary excretion of 11-hydroxycorticosteroids. The decrease in absorption was attributed to drug adsorption on the antacid surface. These results confirm previous in vitro findings.
D015062:11-Hydroxycorticosteroids / Q000652:urine; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability; D003907:Dexamethasone / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D017633:Magnesium Silicates; D008297:Male; D012824:Silicic Acid / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000494:pharmacology*
D015062:11-Hydroxycorticosteroids; D000863:Antacids; D017633:Magnesium Silicates; D012824:Silicic Acid; D012822:Silicon Dioxide; D003907:Dexamethasone; C001671:magnesium trisilicate