Experimental chemotherapy of carcinoma of the human stomach and colon serially transplanted in nude mice.
Human gastric and colon carcinomas serially transplantable in nude mice, designated as St-4, St-15, and Co-3, were used for chemotherapeutic experiments. All tumors showed a 100% take rate and stable growth. Mitomycin-C (MMC), 3 mg/kg body weight, given intraperitoneally 4 times once weekly, showed some inhibiting effect on Co-3, St-15, and St-4 in that order. N1-(2'-Tetrahydrofuryl)-5-fluorouracil (FT-207), 90 mg/kg body weight, intraperitoneally daily for 4 weeks, suppressed the growth of Co-3 and St-15 slightly but with statistical significance, and had no effect on St-4. Co-3, a tumor with more rapid growth and richer vascular supply, was suppressed more by MMC and FT-207. These three transplantable tumors may be useful, not only in evaluating chemotherapeutic agents for use against human gastrointestinal carcinomas, but also for screening of new antitumor agents.
D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy*; D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000188:drug therapy*; D014183:Transplantation, Heterologous
D008937:Mitomycins; D005472:Fluorouracil