Influence of cyclic nucleotides and a phosphodiesterase inhibitor on in vitro human blood neutrophil chemotaxis.
Cyclic AMP and dibutyryl cyclic AMP as well as several 8-substituted analogs of cyclic AMP inhibited in vitro human blood neutrophil chemotaxis. Cyclic GMP enhanced chemotaxis. 8-substitution on the cyclic GMP nucleus markedly dampened the cyclic GMP effect. SQ 20,009, a potent phosphodiesterase inhibitor when tested alone inhibited chemotaxis; it potentiated the inhibition or enhancement of chemotaxis when combined with cyclic AMP or cyclic GMP, respectively.
D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000494:pharmacology; D004974:Etazolate / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009712:Nucleotides, Cyclic / Q000494:pharmacology*
D009539:Nicotinic Acids; D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP; D004974:Etazolate