title: Malignant fibrous histiocytoma of the head and neck.
abstract: Review of the literature reveals of 29 cases of fibrous histiocytoma of the deep structures of the head and neck. Three additional cases are reported: a multicentric case involving the submandibular gland with metastases to the lungs; and intraosseous tumor of the mandible locally invasive; and a submental tumor which rapidly recurred after simple excision. A metastatic potential of 22% is established. The historm, nomenclature, histopathology and clinical features are reviewed. The value of electron microscopy and tissue culture in arriving at the current diagnosis are stressed. Wide excision is the treatment of choice.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D046508:Culture Techniques; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006644:Histiocytes / Q000648:ultrastructure; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis