Timing of mitosis in Physarum polycephalum: effects of agents affecting cyclic AMP concentrations.
Cultures of Physarum polycephalum incubated with caffeine or theophylline for over 100 min prior to mitosis exhibited mitotic delay proportional to the time of treatment before 100 min. Starved cultures exhibited mitotic delay at times of starvation longer than 180 min and slight stimulation from 100-180 min. Dibutyryl cAMP appeared to accelerate reconstruction of the nucleus following mitosis.
D003994:Bucladesine / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D003470:Culture Media; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D008938:Mitosis / Q000187:drug effects*; D009235:Myxomycetes / Q000187:drug effects*; D010804:Physarum / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors
D003470:Culture Media; D002110:Caffeine; D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP