title: An attempt to differentiate selection and amplification in hormone receptor development: the unicellular model.
abstract: Earlier experiments demonstrated that a membrane pattern of Protozoa behaves as a receptor with respect to hormones of higher organisms. This raised the possibility that some selection or strengthening of this unspecific patter is involved in the evolution of the specific membrane patterns of the individual cells of higher organisms. In the present experiments, as a result of continual histamine treatment, the phagocytotic ability of a population of Tetrahymena was increased more intensely than after a single histamine treatment. The phagocytotic rate remained high for some time after the animals were returned from histamine-containing to normal medium. Thus, from the experimental data, it appears likely that as the hormone appears, selection becomes involved in the proliferation of cells possessing receptors. This observation might not only be of phylogenetic interest, but could also be relevant in receptor maturation as manifested in ontogenetic membrane differentiation.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D008954:Models, Biological; D010587:Phagocytosis / Q000187:drug effects; D010802:Phylogeny; D011956:Receptors, Cell Surface; D012641:Selection, Genetic; D013769:Tetrahymena pyriformis / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface; D006632:Histamine