Effect of ACTH 4-10 on passive avoidance of rats lacking vasopressin (Brattleboro strain).
The hypothesis that the effects of ACTH 4-10 on avoidance are mediated via the release of endogenous vasopressin was investigated. To test this hypothesis, we observed the effect of ACTH 4-10 on the passive avoidance of Brattleboro rats with diabetes insipidus resulting from a total genetic deficiency of vasopressin (DI) and Brattleboro rats without diabetes insipidus (HE). Normal Long-Evans rats (LE) were also included for comparison purposes. The results did not support the hypothesis. ACTH 4-10 did influence the passive avoidance of DI rats; this should not have occurred if the release of endogenous vasopressin is necessary for ACTH 4-10 to influence avoidance.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003919:Diabetes Insipidus / Q000378:metabolism; D005260:Female; D051381:Rats; D014667:Vasopressins / Q000172:deficiency / Q000502:physiology*
D014667:Vasopressins; D000324:Adrenocorticotropic Hormone