Erythrocyte membrane phosphorylation in hereditary spherocytosis.
Phosphorylation of erythrocyte membrane proteins by membrane protein kinases was studied in 10 normal subjects and 8 patients with hereditary spherocytosis. No difference between the two groups of subjects was observed in the total phosphorylation, and, the phosphorylation of spectrin and components III and IV 5 in presence and in absence of 3',5'-cyclic AMP. So, no deficiency of membrane protein kinase activity seems to be present in hereditary spherocytosis.
D000328:Adult; D000242:Cyclic AMP / Q000494:pharmacology; D004789:Enzyme Activation; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D010750:Phosphoproteins / Q000097:blood*; D011494:Protein Kinases / Q000097:blood*; D013103:Spherocytosis, Hereditary / Q000097:blood*
D008565:Membrane Proteins; D010750:Phosphoproteins; D000242:Cyclic AMP; D011494:Protein Kinases