Quantitative analysis of disulfiram and its metabolites in human blood by gas-liquid chromatography.
A simple method is described that permits the direct quantitative determination of carbon disulphide, free diethyldithiocarbamate and disulphides derived from disulfiram in 1 ml of a patient's blood. It is based on a gas chromatographic determination of carbon disulphide produced from diethyldithiocarbamate and disulfiram using the head-space technique and a flame-photometric detector. The method is compared with a recently described spectrophotometric method.
D002246:Carbon Disulfide / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods*; D002853:Chromatography, Liquid; D004220:Disulfides / Q000097:blood; D004221:Disulfiram / Q000097:blood*; D004050:Ditiocarb / Q000097:blood; D006358:Hot Temperature; D006801:Humans; D008722:Methods
D004220:Disulfides; D004050:Ditiocarb; D002246:Carbon Disulfide; D004221:Disulfiram