title: [Adjuvant activity of gram-negative bacteria and their structural components (author's transl)].
abstract: Regarding the adjuvant activity of gram-negative bacteria we have to distinguish at least 4 different potencies, i.e., 1) increase in the production of circulating antibodies during the primary and secondary immune responses; 2) induction of susceptibility to systemic anaphylaxis; 3) prompt production of experimental "allergic" diseases, and 4) increase in resistance to infections. Although all gram-negative bacteria contain several structural components with adjuvant potencies, the immunopotentiating effectiveness of the corresponding whole bacteria becomes--with the exception of killed cells of Bordetella pertussis--only detectable to a weak degree.
mesh_terms: D000276:Adjuvants, Immunologic; D000707:Anaphylaxis; D000917:Antibody Formation; D001886:Bordetella pertussis / Q000276:immunology; D002002:Brucella / Q000276:immunology; D003140:Communicable Disease Control; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology; D004731:Endotoxins; D006801:Humans; D011514:Proteus vulgaris / Q000276:immunology; D012475:Salmonella / Q000276:immunology; D012706:Serratia marcescens / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004731:Endotoxins
vernacular_title: Die adjuvante Aktivität gramnegativer Bakterien und ihrer Strukturbausteine.