title: Pathophysiology of myocardial infarction.
abstract: Primary prevention of death from ischemic heart disease requires further understanding of the pathogenesis of this disorder. Cellular defects of cholesterol metabolism may be more significant markers that serum lipid levels for the identification and treatment of atherosclerotic risk. Coronary spasm has been shown to be an important cause of ischemia in the presence and absence of atherosclerotic lesions. Careful manipulation of physiologic variables with vasodilator agents during cardiopulmonary bypass can substantially alter the myocardial oxygen supply-demand relation, thereby minimizing ischemic injury. The cellular basis for loss of mechanical function during ischemia and the factors that determine irreversible injury are yet unknown.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D002302:Cardiac Output / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D006329:Heart Conduction System / Q000503:physiopathology; D006579:Heterozygote; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000097:blood; D007962:Leukocytes / Q000201:enzymology; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011183:Postoperative Complications / Q000188:drug therapy; D014280:Triglycerides / Q000097:blood
chemical_list: D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D010100:Oxygen