Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.
A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.
D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors*; D000596:Amino Acids / Q000032:analysis; D001681:Biological Assay; D003345:Corticosterone / Q000096:biosynthesis; D006801:Humans; D008544:Melanocytes / Q000187:drug effects; D010446:Peptide Fragments / Q000302:isolation & purification; D010455:Peptides / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D010902:Pituitary Gland / Q000032:analysis*
D000596:Amino Acids; D010446:Peptide Fragments; D010455:Peptides; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone