title: [Azidocillin: activity in vitro, pharmacokinetics and therapeutic results in whooping cough].
abstract: In vitro activities of acidocillin and ampicillin were compared in 20 strains of Haemophilus influenzae, 50 strains of Enterococci and 4 strains of Bordetella pertussis by serial dilution test. There were no significant differences between both antibiotics. On Staphylococcus aureus (100 strains) and Streptococcus group A (25 strains) acidocillin was effective at the same degree as phenoxymethylpenicillin. After oral administration of 0.75 g acidocillin (1 h after a standard breakfast) serum peaks in 10 healthy adults were 6.1 +/- 0.51 mug/ml (after 1 1/2 h) which decreased to 0.5 +/- 0.10 mug/ml (after 4 h) and to 0.045 +/- 0.02 mug/ml (after 6 h). Urine-recovery in 9 h after oral administration of 0.75 g was found as of 58%, after i.v. administration of the same dose 78% (absorption rate nearly 74%). Therapy of whooping cough in 12 children with acidocillin (60 mg/kg/die) led to the disappearance of Bordetella pertussis from nasal swabs (only one failure caused by the child's frequent vomiting).
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000667:Ampicillin / Q000378:metabolism / Q000494:pharmacology; D001886:Bordetella pertussis / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010404:Penicillin V / Q000378:metabolism; D010406:Penicillins / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D014917:Whooping Cough / Q000188:drug therapy*
chemical_list: D010406:Penicillins; D000667:Ampicillin; D010400:Penicillin G; D010404:Penicillin V
vernacular_title: Azidocillin. In-vitro-Aktivität, Pharmakokinetik und Behandlungsergebnisse bei Keuchhusten