Type-C oncovirus isolate from human leukemic bone marrow: further in vitro and in vivo characterization.
Rabbit corneal cells transformed by a putative human type-C helper virus pseudotype of the mouse sarcoma virus produce large amounts of transforming and non-transforming viruses. The virions are antigenically related to the woolly monkey (simian) sarcoma-leukemia type-C oncovirus. Typical sarcoma virus lesions developed in newborn rats injected with virus-producing rabbit cells. Cells producing only the putative type-C helper viruses as a result of exposure to a high dilution of transforming virus stock induce lymphosarcomas after inoculation into newborn rats.
D000818:Animals; D001681:Biological Assay; D001853:Bone Marrow / Q000382:microbiology*; D001854:Bone Marrow Cells; D002460:Cell Line; D002472:Cell Transformation, Viral; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D007525:Isoelectric Focusing; D007938:Leukemia / Q000382:microbiology*; D008854:Microscopy, Electron; D051381:Rats; D012190:Retroviridae / Q000276:immunology* / Q000302:isolation & purification; D012513:Sarcoma, Experimental / Q000209:etiology; D010948:Viral Plaque Assay
D007106:Immune Sera