Hemostatic factors in primary hepatocellular cancer.
Detailed coagulation studies were performed in a group of 19 patients with primary hepatocellular cancer (PHC) and the results were compared statistically with the findings in 19 control subjects. Various funcitonal and immunochemical methods were employed in determining the possible presence of functional or structural coagulant protein abnormalities. The patient group was characterized by prolonged prothrombin  times, partial thromboplastin times, and Reptilase times, increased levels of fibrinogen, factor VIII, and factor VIII-related antigen, moderately devreased levels of factor V, factor IX, factor X, antithrombin III, and plasminogen, and reduced levels of factor II and factor VII. Functional, immunochemical, and biochemical analysis failed to detect the presence of acquired protein abnormalities. These findings indicate that hemostatic changes in primary hepatocellular cancer are nonspecific in character. Severe alterations in the plasma levels of one or more of these hemostatic factors may occur.
D000293:Adolescent; D000328:Adult; D000347:Afibrinogenemia / Q000150:complications; D001772:Blood Cell Count; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D001792:Blood Platelets; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000150:complications; D002648:Child; D005167:Factor VII / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time
D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D005167:Factor VII