title: Alpha- and beta-adrenergic receptor stimulation in cultures of beating rat heart cells and its effect on automaticity and cyclic AMP levels.
abstract: Positive chronotropic responses were elicited in rocker cultures of beating ventricle cells of 1 to 4-day old rats by both alpha- and beta-adrenergic receptor stimulation. Only the beta and not the alpha-adrenergic receptor-mediated increase in automaticity was associated with a rise in the level of cyclic AMP in the cultures.
mesh_terms: D000818:Animals; D046508:Culture Techniques; D000242:Cyclic AMP / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D009206:Myocardium / Q000166:cytology; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
chemical_list: D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP