title: EMS-induced dominant lethal dose response curve in DBA/1J male mice.
abstract: An ethyl methanesulfonate (EMS) induced dominant lethal dose response experiment was conducted in strain DBA/1J male mice. Two methods of scoring for dominant lethals, the classic method (dissecting females at mid-pregnancy) and an alternative method (inspection of uterine scars after litters were weaned) were compared. Results indicate that strain DBA/1J has a similar sensitivity to EMS-induced dominant lethals as has been previously reported for other mouse genotypes. Of the two methods used to score dominant lethals, the classic method is more sensitive.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005020:Ethyl Methanesulfonate / Q000494:pharmacology*; D005799:Genes, Dominant; D005804:Genes, Lethal; D005821:Genetic Techniques; D008297:Male; D008698:Mesylates / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D009153:Mutagens; D009154:Mutation
chemical_list: D008698:Mesylates; D009153:Mutagens; D005020:Ethyl Methanesulfonate