Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice.
Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes occurring during radiation leukemogenesis. Low levels of murine leukemia virus (MuLV)-related antigens are also detected on preleukemic thymocytes. Comparative tests on individual mice show no direct correlation between TL and MuLV antigen expression.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis; D000961:Antilymphocyte Serum / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D009052:Leukemia Virus, Murine / Q000276:immunology; D007953:Leukemia, Radiation-Induced / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology; D013953:Thymus Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens