Persistent shedding of adenovirus in urine of chimpanzees.
A new adenovirus, designated Pan 11, was isolated repeatedly from the urine of several chimpanzees for more than 1 year. One chimpanzee had chronic interstitial nephritis; the others were healthy. Most chimpanzees tested had neutralizing antibodies to Pan 11 virus in the serum; three people who worked with chimpanzees also acquired antibodies. Transplantable rhabdomyosarcomas developed in hamsters inoculated as newborns with Pan 11 virus.
D000256:Adenoviridae / Q000302:isolation & purification*; D000257:Adenoviridae Infections / Q000382:microbiology; D000261:Adenoviruses, Simian / Q000276:immunology / Q000302:isolation & purification*; D000818:Animals; D003168:Complement Fixation Tests; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral; D006168:Guinea Pigs; D000882:Haplorhini; D006386:Hemagglutination Tests; D006801:Humans; D009374:Neoplasms, Experimental / Q000209:etiology; D009500:Neutralization Tests; D002679:Pan troglodytes / Q000382:microbiology*; D011817:Rabbits; D012208:Rhabdomyosarcoma / Q000209:etiology; D014556:Urine / Q000382:microbiology*