title: Evidence for the presynaptic location of adenylate cyclase and the cyclic AMP-stimulated protein kinase which is bound to synaptic membranes.
abstract: By comparison of activities measured with either intact or ruptured synaptosomes it was found that half of the cerebral adenylate cyclase is presynaptic while all the membranes bound, cyclic AMP-stimulated protein kinase activity appears to be presynaptic with the cyclic AMP receptor facing inward.
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000302:isolation & purification*; D000818:Animals; D002458:Cell Fractionation; D002540:Cerebral Cortex / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D011494:Protein Kinases / Q000302:isolation & purification* / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000201:enzymology*
chemical_list: D000242:Cyclic AMP; D011494:Protein Kinases; D000263:Adenylate Kinase; D000262:Adenylyl Cyclases