Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
In vitro drug metabolism in the Hartley guinea pig was compared with that in two inbred guinea pig strains used as carriers for the line 10 hepatoma. We observed minor differences in enzyme specific activity among the three strains. Three weeks after intradermal inoculation of Strain 2 guinea pigs with line 10 hepatoma cells, cytochrome P450 levels and aminopyrine demethylase activity were significantly decreased. Seven to 10 days after inoculation with the ascites form of the tumor, the activities of aniline and biphenyl hydroxylases, p-aminobenzoic acid N-acetyltransferase, and dichloronitrobenzene glutathione S-aryltransferase, in addition to those of cytochrome P450 and aminopyrine N-demethylase, were probably also described.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006168:Guinea Pigs / Q000378:metabolism*; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000378:metabolism; D013045:Species Specificity
D000970:Antineoplastic Agents; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase