Effect of methylazoxymethanol acetate on adenylate cyclase and 5'-nucleotidase in rat liver plasma membranes.
A single tumorigenic dose of methylazoxymethanol acetate increased adenylate cyclase activity in total liver homogenates 70-100% by the seventh day after treatment. The increased activity occurred in the plasma membranes rather than in the nuclei and was accompanied by a significant increase in 5'-nucleotidase activity. The data indicate that the carcinogen may alter the structure of the plasma membrane.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008746:Methylazoxymethanol Acetate / Q000494:pharmacology*; D009369:Neoplasms / Q000209:etiology; D009708:Nucleotidases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate; D009708:Nucleotidases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases