[Transplacental carcinogenic action of diethylnitrosamine in the Dzungarian hamster (author's transl)].
After transplacental application (30 mg/kg i.p., 3 days until 6 hours a. p.), diethylnitrosamine induces a high rate (76.2 per cent) of bronchiolar tumours in the lung of the Dzungarian hamster. These tumours were classified as papillary or tubulous adenomas and carcinomas. Furthermore, eome tumours were observed in other organs. The problem of organotropism of diethylnitrosamine, especially among different hamster hamster species, is discussed.
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D006224:Cricetinae; D003537:Cystadenoma / Q000139:chemically induced; D004052:Diethylnitrosamine / Q000378:metabolism; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008431:Maternal-Fetal Exchange; D009602:Nitrosamines / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
D009602:Nitrosamines; D004052:Diethylnitrosamine
Transplazentare kanzerogene Wirkung von Diäthylnitrosamin beim Dsungarischen Hamster