[Effects of methylcyclopentadienyl manganese tricarbonyl (MMT) on rat liver mitochondria. II. Activity-structure relation (author's transl)].
The action of various manganese organic compounds, which are structural analogs of methylcyclopentadienyl manganese tricarbonyl (MMT), was investigated. Only the cyclopentadienyl manganese tricarbonyl compounds are effective inhibitors of mitochondrial respiration, but only when associated with NAD+-linked substrates. The manganese tricarbonyl group is required for this mitochondrial respiration inhibition. The substitutions operated on the cyclopentadienyl cycle also interfere and increase the inhibitory effect. Meanwhile, the benzoyl and thenoyl groups are more effective than the methyl group. The effects of the various compounds result from their special electronic configuration.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003517:Cyclopentanes / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects*; D009243:NAD / Q000378:metabolism; D009942:Organometallic Compounds / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship
D003517:Cyclopentanes; D005971:Glutamates; D006885:Hydroxybutyrates; D008293:Malates; D009942:Organometallic Compounds; D009243:NAD; C009907:2-methylcyclopentadienyl manganese tricarbonyl; D008345:Manganese; D000244:Adenosine Diphosphate
Action du manganese methylcyclopentadienyle tricarbonyle (MMT) sur les mitochondries. II. Relation activite-structure.