[Differing carcinogenic activity in BD-rats of 1-phenyl- and 1-(pyridyl-3)-3,3-diethyltriazene after single doses on 1., 10. or 30. day of life (author's transl)].
1-Phenyl- and 1-(pyridyl-3)-3,3-diethyltriazene have been investigated for carcinogenic effects in BD-rats after subcutaneous injection of a single dose of 50 mg of the compounds on day 1, 10, or 30 of life. The phenyl derivative showed a lower carcinogenic activity in comparison with the pyridyltriazene. Predominantly neurogenic tumors were observed. These were seen much more on treatment on day 1 or 10 of life than on treatment on day 30. The results confirm that the nervous system of rats is a target organ predominantly during early postnatal life.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental; D009380:Neoplasms, Nerve Tissue / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D014226:Triazenes / Q000008:administration & dosage / Q000494:pharmacology*
D002273:Carcinogens; D014226:Triazenes
Unterschiedliche carcinogene Wirkungen von 1-Phenyl- und 1-(Pyridyl-3)-3,3-diäthyl-triazen an BD-Ratten nach Gabe einer Einzeldosis am 1., 10. oder 30. Lebenstag