Chromosome analyses of two recently established human tumour cell lines derived from a carcinoma of the oesophagus and a primary liver tumour.
An oesophageal carcinoma cell line was karyotyped at passages 8,48,64 and 88. It showed a persistent loss of D group chromosomes and subtelocentric, acrocentric, dicentric and other markers were frequently present. During 80 passages the modal number declined from 60,5 to 54,09. The chromosome pattern of a hepatoma cell line was studied at passages 15/17 and 28. It showed a loss of D and G group chromosomes and the presence of various markers including a D/G fusion.
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002460:Cell Line; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D004938:Esophageal Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male