title: An adult case of canine neuronal ceroid-lipofuscinosis.
abstract: Intraneuronal accumulation of cytosomes with the fluorescent and tinctorial properties of ceroidlipofuscin occurred in the C.N.S. of a fully matured dog with signs of slowly progressive cerebellar disease. Ultrastructural study revealed various membrane-bound inclusions in addition to typical lipofuscin granules. The clinicopathologic findings in this case were contrasted with those occurring in English Setters with juvenile neuronal ceroid-lipofuscinosis, and compared with those reported in Kufs' disease in man.
mesh_terms: D000328:Adult; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006801:Humans; D002479:Inclusion Bodies; D008064:Lipidoses / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron; D011689:Purkinje Cells; D013577:Syndrome