A testosterone-secreting adrenal cortical adenoma.
A virilizing, gonadotrophin-responsive adrenal cortical adenoma was removed from a 54-year-old woman. Following removal of the tumour, which contained and secreted androgens and estradiol, serum gonadotrophins rose to menopausal levels and the patient experienced menopausal symptoms. Pre-operative attempts to localize the source of androgens were unsuccessful.
D000236:Adenoma / Q000097:blood / Q000378:metabolism*; D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000728:Androgens / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D008875:Middle Aged; D013739:Testosterone / Q000378:metabolism*
D000728:Androgens; D006065:Gonadotropins, Pituitary; D013739:Testosterone; D004958:Estradiol