Detection of Mason-Pfizer monkey virus infection by syncytia formation of human cells doubly transformed by Rous sarcoma virus and simian virus 40.
Human cells doubly transformed by Rous sarcoma virus and SV40 (RSb cells) formed syncytia by cocultivation with Mason-Pfizer monkey virus (MPMV)-producing cells. This cell fusion was blocked by anti-MPMV serum indicating that the phenomenon is MPMV specific. The RSb cells were successfully used for MPMV infectivity assay in the same manner as KC cells.
D000914:Antibodies, Viral; D001358:Avian Sarcoma Viruses; D002459:Cell Fusion; D002460:Cell Line; D002472:Cell Transformation, Viral; D012328:RNA Viruses / Q000254:growth & development* / Q000276:immunology; D013539:Simian virus 40
D000914:Antibodies, Viral