title: The role of protein synthesis in polymorphonuclear leukocyte phagocytosis II.
abstract: Polymorphonuclear leukocytes collected from healthy human volunteers were treated with puromycin which inhibited protein synthesis in the cell. The neutrophils exhibited a marked decrease in phagocytosis after 1 h. The myeloperoxidase mediated conversion of iodide to a protein-bound form was also decreased. Hexosemonophosphate shunt activity remained similar for both puromycin treated PMN and control cells at 1 h. The results suggest that new protein synthesis is necessary to maintain PMN function at full capacity.
mesh_terms: D005947:Glucose / Q000378:metabolism; D006801:Humans; D007455:Iodine / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D014176:Protein Biosynthesis; D011691:Puromycin / Q000494:pharmacology; D013210:Staphylococcus; D013997:Time Factors
chemical_list: D011691:Puromycin; D007455:Iodine; D009195:Peroxidase; D005947:Glucose