Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid.
The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.
D000818:Animals; D001500:BCG Vaccine; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology*; D003470:Culture Media; D004731:Endotoxins / Q000494:pharmacology; D008055:Lipids / Q000097:blood* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D008970:Molecular Weight; D009163:Mycobacterium bovis / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology*
D001500:BCG Vaccine; D003470:Culture Media; D004731:Endotoxins; D008055:Lipids; D008077:Lipoproteins, LDL; D008563:Membrane Lipids; D002784:Cholesterol