title: [Clinical endocrine investigations in patients with pituitary adenoma (author's transl)].
abstract: LH-RH tests of hypothalamo-pituitary gonadotropinfunction were performed in 26 patients with pituitary adenomata before and after prolactin suppression and/or surgical treatment. Various degrees of galactorrhea together with menstrual disorders were the key symptoms in all patients. There was a significant association of elevated prolactin levels with impaired LH-responses. Seven patients have undergone transspenoidal dissection of the pituitary adenoma and in five of them the pituitary LH-response reverted to normal (R2) after surgery. Nine of 15 amenorrhoic patients had a recurrence of menstrual cyclicity, partly biphasic within 3 months and a normalized LH-response after Bromocriptin therapy. 19 of our patients were desirous of pregnancy. Five pregnancies were confirmed within 4 months of treatment.
mesh_terms: D000239:Adenoma, Acidophil / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000238:Adenoma, Chromophobe / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D008599:Menstruation Disturbances / Q000209:etiology; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011247:Pregnancy; D011388:Prolactin / Q000097:blood
chemical_list: D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin
vernacular_title: Klinisch-endokrinologische Untersuchungen bei Patientinnen mit einem Hypophysenadenom.