[Binding of 2-acetylaminofluorene-9-14C with rat liver nucleic acids during malignization and in primary hepatomas].
The residual binding of 9-14C-2-Acetylaminofluorene (9-14C-2-AAF) with rat liver nuclei acids was investigated during hepatocarcinogenesis two weeks after a single injection of 9-14C-2-AAF. Up to 6 months feeding of the animals with unlabeled 2-AAF, the RNA of their liver proved to bind increased amounts of 9-14C-2-AAF in comparison with normal liver. The binding of 9-14C-2-AAF with DNA in primary hepatomas was mainly due to the RNA heterodispersed components with the maximum level in the 18S-fraction, as well as with the biopolymere fractions with the sedimentation constant of 10 and 5S enriched with polyadenylate fragments.
D015073:2-Acetylaminofluorene / Q000378:metabolism*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D005449:Fluorenes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D009374:Neoplasms, Experimental; D012334:RNA, Neoplasm / Q000378:metabolism*; D051381:Rats
D004273:DNA, Neoplasm; D005449:Fluorenes; D012334:RNA, Neoplasm; D015073:2-Acetylaminofluorene
Sviazyvanie 2-atsetilaminofluorena-9-14C s nukleinovymi kislotami tkani pecheni krys v protsesse malignizatsii i v pervichnykh gepatomakh