Neuronal responses to extracellularly applied cyclic AMP:Role of the adenosine receptor.
At low doses, theophylline blocks the neuronal depressant effects of 5'-AMP, but not cyclic AMP. Higher doses (100 mg/kg) block cyclic AMP responses and reduce the effects of noradrenaline and GABA. It is concluded that cyclic AMP does not depress neurones via the adenosine receptor.
D000241:Adenosine / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011953:Receptors, Cyclic AMP; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D011953:Receptors, Cyclic AMP; D000628:Aminophylline; D000249:Adenosine Monophosphate; D005680:gamma-Aminobutyric Acid; D000242:Cyclic AMP; D000241:Adenosine; D009638:Norepinephrine