title: Adrenocorticotropin. 48. Synthesis and biological activity of (15, 16-D-lysine, 17, 18-D-arginine)-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin.
abstract: The peptide [15, 16-D-lysine, 17, 18-D-arginine]-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin have been synthesized by the solid-phase method. The nonadecapeptide was shown to possess 10-15% of the steroidogenic activity and 3% of the lipolytic activity of adrenocorticotropin-(1-19). The all-D-retropeptide showed no activity and exhibited no inhibitory activity in steroidogenesis and lipolysis.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine; D004590:Electrophoresis, Paper; D008239:Lysine; D010454:Peptide Termination Factors; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D010454:Peptide Termination Factors; D010455:Peptides; D000324:Adrenocorticotropic Hormone; D001120:Arginine; D008239:Lysine