[Immunization of the nude mouse against mouse hepatitis virus through the transfer of sensitized lymphocytes].
Nude (nu/nu) mice failed to resist to virulent mouse hepatitis virus (MHV) infection after vaccination with inactivated virus. Resistance was induced in nu/nu mice by the transfer of spleen cells from heterozygous haired (nu/ +) mice concomitantly with the vaccination, and the effect was more remarkable with spleen cells from immunized nu/ + mice. Antibody was demonstrable in nu/nu mice having received nu/ + cells and survived challenge infection.
D000818:Animals; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*; D006517:Murine hepatitis virus / Q000276:immunology* / Q000472:pathogenicity; D013154:Spleen / Q000276:immunology / Q000637:transplantation
Immunisation de la souris "nude" contre le virus de l'hépatite murine par transfert de lymphocytes sensibilisés