[Ultrastructural aspects of chloroquin-keratopathy (author's transl)].
This reports deals with ultrastructural findings in chloroquin-keratopathy on the basis of three cases. Cytoplasmic inclusions are found in the corneal epithelium, alternately in the form of lamellar bodies, dense bodies, or as vacuoles with a variable content. Similar results are reported in the literature with other drugs and permit the conclusion that a pathologic mechanism depending on the amphiphilic character of these substances is involved. Thus they are able to undergo reactions with phosphilipids, disturbing the normal phosphilipid catabolism and leading to a drug-induced phospholipidosis.
D002738:Chloroquine / Q000009:adverse effects*; D003315:Cornea / Q000648:ultrastructure*; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008064:Lipidoses / Q000139:chemically induced; D008854:Microscopy, Electron; D010743:Phospholipids / Q000378:metabolism
D010743:Phospholipids; D002738:Chloroquine
Das ultrastrukturelle Bild der Chloroquin-Keratopathie