The effect of changes in dietary sodium on lung and serum antiotensin-I-converting enzyme in the rat.
Three groups of rats were fed a sodium-deficient diet, a normal sodium diet, and a diet high in sodium for up to 8 weeks. Animals on a sodium-deficient diet had a significant decrease of serum sodium levels with a concomitant increase of renal renin granules. The reverse was true in rats on a high sodium diet whereas no significant changes in renin granulation were seen in rats fed a normal sodium diet. The changes in serum sodium levels and in number of renal renin granules were not associated with changes in lung or serum angiotensin-I-converting enzyme activity which did not vary significantly in any of the three groups of rats throughout the experiment. It is, therefore, suggested that such activity is independent of changes in sodium balance sufficient to affect the renal renin content.
D000818:Animals; D004032:Diet; D005260:Female; D007606:Juxtaglomerular Apparatus; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D051381:Rats; D012964:Sodium / Q000097:blood / Q000494:pharmacology*
D012964:Sodium; D007703:Peptidyl-Dipeptidase A; D011188:Potassium