Hepatocarcinogenic effects of N-nitroso-N-methylurea in guinea pigs.
Intragastric administration of N-nitroso-N-methylurea to strain 13 male guinea pigs, at a weekly dosage of 7.5 mg/kg for 15 weeks and then twice weekly for a subsequent 15 weeks, induced high toxicity, as evidenced by weight loss and mortality and a high incidence of malignant neoplasms, over a total observational period of 40 weeks. The neoplasms included hepatic angiosarcomas, cholangiocarcinomas, and generalized lymphoblastic lymphomas.
D002759:Adenoma, Bile Duct / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D006168:Guinea Pigs; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009607:Nitrosourea Compounds / Q000633:toxicity*
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea