title: [Ultrastructural changes in the livers of rats following multiple injections of corticotropin and sodium ribonucleinate].
abstract: The mechanism of the corticotropin (ACTH) action was studied. It was found that daily injections of ACTH-zinc-phosphate (5 un./100 g) to intact albino rats for 14 days result in a disturbance of the hepatocytes ultrastructure. When the hormone was injected in combination with sodium ribonucleate (5 mg/100 g), the deviations were less pronounced, injections of the hormones to adrenalectomized rats did not change the ultrastructure of hepatocytes.
mesh_terms: D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D004721:Endoplasmic Reticulum / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D012313:RNA / Q000494:pharmacology*; D051381:Rats
chemical_list: D008112:Liver Glycogen; D012313:RNA; D000324:Adrenocorticotropic Hormone
vernacular_title: Ul'trastrukturnye izmeneniia v pecheni krys pri mnogokratnykh in"ektsiiakh kortikotropina i ribonukleinata natriia