Mammary tumors, hepatocellular carcinomas, and pancreatic islet changes in C3H-Avy Mice.
Studies of tumor incidence and assorted lesions found in 187 C3H-Avy mice throughout their natural life-spans revealed the following: Hepatocellular carcinomas occurred in 54.3% of males, mammary carcinomas in 95% of females, pancreatic islet cell adenomas in 9.4% of males and in no females, and pancreatic islet cell hyperplasia in 41% of males and 23% of fefemales. Islet cell hyperplasia and adenomas appeared to consist predominantly of alpha and delta cells. Multiple tumors, or hyperplasia, or both, of a single site or of multiple sites occurred as frequently in males as they did in females--49.6% and 51.7% respectively. The most frequent neoplasms were hepatocellular carcinomas and islet cell tumors or hyperplasia in males (45.7%) and multiple mammary tumors in females (30%). Heretofore unreported tumors found in this strain of mouse were 12 islet cell adenomas, 2 spindle cell tumors of the meninges and olfactory lobes, a squamous cell carcinoma of the nasal turbinates, and a schwannoma of the spermatic cord.
D007516:Adenoma, Islet Cell / Q000235:genetics*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D005260:Female; D007181:Inclusion Bodies, Viral; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics / Q000648:ultrastructure; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*; D012737:Sex Factors