Prostaglandin restoration of the interferon response of hyporeactive animals.
Virus-infected animals and those bearing various types of malignancies progressively lose the ability to respond to interferon inducers. The interferon response of virus-infected animals could be restored to normal levels when inducers were administered with certain prostaglandins. This suggests that prostaglandins may enhance the therapeutic efficacy of interferon inducers as antiviral and antineoplastic agents.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D004686:Encephalomyocarditis virus; D005122:Exudates and Transudates / Q000378:metabolism; D005622:Friend murine leukemia virus; D009980:Influenza A virus; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D007942:Leukemia, Experimental / Q000503:physiopathology; D051379:Mice; D009522:Newcastle disease virus; D011453:Prostaglandins / Q000494:pharmacology*; D012672:Semliki forest virus; D014777:Virus Diseases / Q000503:physiopathology*
D007369:Interferon Inducers; D011453:Prostaglandins; D007372:Interferons