[Cerebral damage and cytomegalovirus infection (author's transl)].
Serological tests were performed on 58 children with microcephalus and 223 children with cerebral damage but no microcephalus (all patients were living in the Munich region). In the microcephalus group 38% had antibodies against cytomegalovirus, while in healthy controls the incidence was only 18%. Mean titre levels were significantly higher in microcephalic children. Of eleven microcephalic children seven were cytomegalovirus excreters: all of the latter had severe cerebral defects. On the other hand, in patients with cerebral damage but no microcephaly there was no difference serologically or with regard to virus excretion from healthy controls. The authors suggest, in conformity with opinions expressed by others, that there is a definite connection between--usually unrecognised--cytometalovirus infection and certain forms of cerebral damage. They may be atypical and symptom-poor diseases in which CNS signs appear only in the course of time.
D000914:Antibodies, Viral / Q000032:analysis; D001925:Brain Damage, Chronic / Q000209:etiology* / Q000276:immunology; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008831:Microcephaly / Q000209:etiology* / Q000276:immunology
D000914:Antibodies, Viral
Zerebralschäden und Zytomegalievirusinfektion.