[Tracer kinetic studies of the cholesterol metabolism in patients with hypercholesterolemia].
For the examination of the cholesterol metabolism in patients with normal and increased serum cholesterol the 3H-cholesterol was used. The tracer-kinetic investigation programme consisted of the examination of the serum for free and esterified cholesterol as well as the separation in VLDL-, LDL- AND HDL-fractions. The establishment of the content of radioactivity of the individual samples was carried out in the LSC-nitrobeta 1210. Specific activity-time-curves were established and fitted according to a mathematical programme. The most essential findings of the evaluation of these curves resulted in a clearly changed turnover of the LDL-fraction. Possible causes for the disturbed LDL-turnover were discussed.
D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000032:analysis; D008077:Lipoproteins, LDL / Q000032:analysis*; D008079:Lipoproteins, VLDL / Q000032:analysis; D014316:Tritium
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014316:Tritium; D002784:Cholesterol
Tracerkinetische Untersuchungen des Cholesterolstoffwechsels bei Patienten mit Hypercholesterolämie.