title: Effect of low density lipoprotein on proteoglycan synthesis by aorta cells in culture.
abstract: Increasing the content of human serum low density lipoprotein in the growth medium led to greater incorporation of 35S-sulfate into proteoglycan (mostly into dermatan sulfate) by primary aorta cells but did not affect similar incorporation by fibroblast cells. These results suggest a mechanism which can explain the increased deposition of lipid in aorta due to hyperlipidemia.
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D003470:Culture Media; D005347:Fibroblasts / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology* / Q000502:physiology; D011509:Proteoglycans / Q000096:biosynthesis*; D011817:Rabbits; D013431:Sulfates / Q000378:metabolism
chemical_list: D003470:Culture Media; D008077:Lipoproteins, LDL; D011509:Proteoglycans; D013431:Sulfates