Cytomegalovirus as a frequent cause of Guillain-Barré syndrome.
In 10 patients with Guillain-Barré syndrome a preceeding cytomegalovirus infection could be demonstrated by virus-specific IgM antibodies that were present in high titers in 9 of the 10 patients in the first serum specimen. The IgM antibodies to cytomegalovirus were detected by a sensitive "double" indirect immunofluorescence technique. In most of our cases (8 of 10) the complement-fixing antibody titers had already reached high levels on admission into a hospital, and significant titer changes were not observed. Cytomegalovirus was isolated from the urine of five patients.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D011128:Polyradiculopathy / Q000209:etiology* / Q000276:immunology; D014556:Urine / Q000382:microbiology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M