Activities of the androgen-responsive receptor of the prostatic plasma membrane.
Evidence of the presence of an androgen-activated "gatekeeper" receptor in the human prostate plasma membrane is presented. Not only does testosterone in vitro very rapidly accelerate uptake of alpha-aminoisobutyric acid into prostate slices but also its metabolite, dihydrotestosterone, greatly increases the rates of phosphorylation and dephosphorylation of the cation-dependent ATPase of isolated membranes. The relationship of this regulatory unit to prostatic physiologic processes is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000613:Aminobutyrates / Q000378:metabolism; D000728:Androgens / Q000378:metabolism*; D000738:Androsterone / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D011467:Prostate / Q000166:cytology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology
D000613:Aminobutyrates; D000728:Androgens; D011956:Receptors, Cell Surface; D013196:Dihydrotestosterone; D010758:Phosphorus; D013739:Testosterone; D000738:Androsterone; D000251:Adenosine Triphosphatases