[The enzymatic linkage of fibrinogenesis and fibrinolysis (author's transl)].
The coagulation cascade can be triggered by an extrinsic or intrinsic signal. The response is a highly complex activation sequence of several serine proteases. This physiological event of hemostasis comprises the activation of the kinin system as well as other plasma constituents. As an expression of the dynamic balance between fibrinogenesis and fibrinolysis plasminogen is activated either by proteases deriving from the blood clotting cascade or by its linkage to the kallikrein kinin system. Inhibitors of the fibrinolytic events have to be directed specifically against serine proteases or they may be used to interact with the substrate fibrin thus its degradation is delayed.
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001358:Avian Sarcoma Viruses; D002471:Cell Transformation, Neoplastic; D003907:Dexamethasone / Q000494:pharmacology; D005174:Factor XII; D005337:Fibrin / Q000096:biosynthesis*; D005341:Fibrinolysin / Q000096:biosynthesis; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007739:L Cells / Q000187:drug effects; D008239:Lysine / Q000494:pharmacology; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism; D010960:Plasminogen Activators; D011956:Receptors, Cell Surface; D013539:Simian virus 40; D013300:Streptokinase / Q000378:metabolism; D014148:Tranexamic Acid / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D000614:Aminocaproates; D011956:Receptors, Cell Surface; D014148:Tranexamic Acid; D003907:Dexamethasone; D005174:Factor XII; D005337:Fibrin; D010958:Plasminogen; D010447:Peptide Hydrolases; D013300:Streptokinase; D010960:Plasminogen Activators; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; D008239:Lysine
Die enzymatische Kopplung von Fibrinogenese und Fibrinolyse.