[Possible concentration-dependent mechanism of action exerted by epinephrine on giant neurons].
The results of an investigation carried out suggest that both the stimulating and inhibitory action of epinephrine on the neuronal activity are mediated by the adenylate-cyclase system. The reason of the effect of epinephrine depending on its concentration is, apparantly, the polyfunctionality of the "second mediator"--cAMP and the primordial existence in the cells of processes oppositely influencing its functional activity, whose intensity depends on the concentration of cAMP.
D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008195:Lymnaea; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology
D000242:Cyclic AMP; D004837:Epinephrine
Vozmozhnyi mekhanizm kontsentratsionnoĭ zavisnmosti deistviia adrenalina na gigantskie neipony.