title: Mechanism of action of luteinizing hormone and follicle-stimulating hormone on the ovary in vitro.
abstract: The mechanism of action of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) upon various cell types of the mammalian ovary is reviewed. Emphasis is placed upon in vitro studies using organ and cell culture as well as short-term incubations. FSH and LH actions upon the following ovarian functions are discussed: steroidogenesis and metabolism of the ovary as a whole and of the isolated follicle and its component cell types, the granulosa and thecal cells, as well as folliculogenesis and follicular growth, oocyte maturation, follicular rupture, and corpus luteum maintenance and steroidogenesis. The roles of gonadotropin receptors, AMP, prostaglandins, protein kinase, and protein synthesis in these LH and FSH actions are discussed. Intra-ovarian regulation of LH and FSH action is reviewed, including a discussion of the possible roles of follicular fluid inhibitors upon oocyte maturation and granulosa cell luteinization.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003338:Corpus Luteum / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005333:Fetus; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006107:Granulosa Cells / Q000378:metabolism; D007986:Luteinizing Hormone / Q000502:physiology*; D008954:Models, Biological; D009865:Oocytes / Q000502:physiology; D009924:Organ Culture Techniques; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000378:metabolism / Q000502:physiology*; D010060:Ovulation; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology; D011817:Rabbits; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis
chemical_list: D011453:Prostaglandins; D011956:Receptors, Cell Surface; D013256:Steroids; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP