[Effect of some organosilicon compounds (silatranes) on the biosynthesis of collagen in cartilagenous tissue of chick embryo].
Effect of some organosilicon compounds from the class of silatranes on the biosynthesis of collagen in cartilagenous tissue of chick embryos in vitro was studied. The criteria for assessing the intensity of collagen biosynthesis was the formation of peptide bond 14C-hydroxyproline from 14C-proline of incubation medium. All the compounds studied (methylsilatrane, ethoxysilatrane and chloromethylsilatrane) stimulated total protein biosynthesis and collagen biosynthesis in cartilagenous tissue of chick embryos. The most pronounced stimulation of the biosynthesis of collagen was observed at 3-10(-3) M concentration of silatranes within 180 min. of incubation (14C-proline was added to the incubation medium 60 min after the beginning of the incubation). The activity of partly purified collagen prolyl-hydroxylase in the presence of silatranes was also studied.
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002356:Cartilage / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006909:Hydroxyproline / Q000378:metabolism; D017646:Organosilicon Compounds; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D012825:Silicon / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D019086:Bridged Bicyclo Compounds, Heterocyclic; D017646:Organosilicon Compounds; C015503:silatrane; D003094:Collagen; D011392:Proline; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline; D012825:Silicon
Vliianie nekotorykh kremniĭorganicheskikh soedineniĭ (silatranov) na biosintez kollagena v khriashchevoĭ tkani kurinykh embrionov.