Cytochrome C as antidote in mice poisoned with the mushroom toxin alpha-amanitin.
The curative potencies of cytochrome c applied 8 hours after lethal doses of alpha-amanitin in mice are confirmed. In a comprehensive series of experiments, various dosage schedules were explored. Optimal effects with cure rates approaching 100% were obtained either with repeated doses of cytochrome c or by combining it with penicillin. Male mice are more sensitive to alpha-amanitin than female mice but it was established that the antidote is effective in both sexes. Substantial cure rates are seen even when the treatment after supralethal doses of alpha-amanitin is withheld for 12 hours after the poisoning.
D000545:Amanita; D000546:Amanitins / Q000506:poisoning*; D000818:Animals; D003574:Cytochrome c Group / Q000008:administration & dosage*; D004357:Drug Synergism; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009145:Mushroom Poisoning / Q000188:drug therapy; D010400:Penicillin G / Q000008:administration & dosage; D012737:Sex Factors
D000546:Amanitins; D003574:Cytochrome c Group; D010400:Penicillin G