Immunoreactive beta-endorphin in the rat mammotropic transplantable tumor (MtT-F4).
Raised levels of what appeared to be beta-lipotropin (beta-LPH), beta-melanotropic hormone, and beta-endorphin were detected by radioimmunoassay in the plasma of rats bearing the mammotropic transplantable pituitary tumor MtT-F4. The immunoreactivity to anti-beta-endorphin in the assay was displayed by a substance with the molecular weight of beta-LPH, as determined by gel filtration. Isolated cells of MtT-F4 tumor incubated in vitro released immunoreactive beta-LPH and beta-endorphin, with the expected molecular weights, into the incubation medium. These results suggest that the pituitary transplantable rat tumor MtT-F4 secretes peptides structurally related to beta-LPH.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004723:Endorphins / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D011916:Rats, Inbred F344; D014185:Transplantation, Isogeneic; D008083:beta-Lipotropin / Q000378:metabolism
D004723:Endorphins; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin