[Activity of glucose-6-phosphate metabolism enzymes in the livers of rats with experimental valekson poisoning].
The activity of hexokinase, glucose-6-phosphatase and glucose-6-phosphoric dehydrogenase was studied in the liver of rats after one hour, one and five days after a single oral administration of organic phosphorus insecticide valekson. It was determined that administration of the preparation led to an increase of activity in the homogenate and solubilization of glucose-6-phosphatase, activation of glucose-6-phosphoric dehydrogenase and inhibition of hexokinase. The changes were maximum one hour after the administration of the compound. The results show that a decrease of the intensity of glucose-6-phosphate formation and metabolism is one of the pathogenetic factors in the development of valekson-induced intoxication.
D000818:Animals; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D007306:Insecticides / Q000506:poisoning*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009946:Organothiophosphorus Compounds; D051381:Rats
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C003135:phoxim; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D005952:Glucose-6-Phosphatase
Aktivnost' fermentov obmena gliukozo-6-fosfata v pecheni krys pri éksperimental'noĭ intoksikatsii valeksonom.