Interaction of aflatoxin with infectious bursal disease virus infection in young chickens.
Young White Leghorn chickens fed 2.5 microgram of aflatoxin (Afl) per g of diet from hatching until 4 weeks old and infected with infectious bursal disease virus (IBDV) at 3 weeks old had significantly higher mortality and more severely depressed body weights than chicks with aflatoxicosis or IBD alone. Afl-IBDV chicks also had more extensive gross and microscopic changes characteristic of IBD than did IBDV-chicks. None of the treatments significantly reduced antibody responses to Newcastle disease(ND) and infectious bronchitis vaccines or increased susceptibility to challenge with virulent NDV. In a similar experiment chickens fed Afl from hatching to 7 weeks of age had no marked depression in immune response to ND vaccination.
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D001835:Body Weight; D002645:Chickens; D001351:Infectious bronchitis virus / Q000276:immunology; D007243:Infectious bursal disease virus; D009522:Newcastle disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology; D012088:Reoviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
D000348:Aflatoxins; D000914:Antibodies, Viral