[Activity of glycolysis enzymes in kidneys, blood serum and urine with toxicity of certain segments of the nephron].
The activity of hexokinase, glycose-6-phosphatase, phosphofructokinase, fructose diphosphate aldolase and ketose-1-phosphate aldolase was studied in kidneys, blood serum and urine or rats, the proximal and distal areas of their nephron being affected with the chemical substances. A pronounced decrease in the activity of the mentioned enzymes in the renal tissue was greater with afection of the nephron proximal area. The activity of the mentioned enzymes in urine, vice versa, increases sharply and in blood serum it was almost unchanges (exception for keto-1-phosphate aldolase). The pronounced enzyme uria may reflect the deep changes in epithelium cells of canals, especially of proximal ones where the enzymes under study are mainly localized.
D000446:Aldehyde-Lyases / Q000378:metabolism; D000818:Animals; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism; D007668:Kidney / Q000201:enzymology* / Q000473:pathology*; D009399:Nephrons / Q000473:pathology*; D010732:Phosphofructokinase-1 / Q000378:metabolism; D051381:Rats
D006593:Hexokinase; D010732:Phosphofructokinase-1; D005952:Glucose-6-Phosphatase; D000446:Aldehyde-Lyases; D005634:Fructose-Bisphosphate Aldolase
Aktivnost' fermentov glikoliza v pochkakh, syvorotke krovi i moche pri toksicheskom porazhenii otdel'nykh segmentov nefrona.