title: Tropine derivatives with central activities. Part II: Solvolysis of N-substituted nortropine methanesulfonates.
abstract: The preparation and the reaction kinetical properties in solvolysis of a series of N-substituted nortropine methanesulfonates 1-8 are described. It was found that the rate of solvolysis depends on the nature of the N-substituents considerably. The solvolysis rates can be brought into correlation with the electron donating and withdrawing and steric properties of the N-substituents. Methane-sulfonates of other two bicyclic aminoalcohols 10, 11 were also prepared and kinetically studied.
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008698:Mesylates; D014326:Tropanes / Q000138:chemical synthesis*
chemical_list: D000605:Amino Alcohols; D008698:Mesylates; D014326:Tropanes