[Action of actidione on the multiplication of Aujeszky's disease virus].
Studied was the effect of actidione on the propagation of the Aujeszky's disease virus (strains 2,7,10--virulent,, and strain MK--avirulent virus mutant). It was found that at a concentration of 2 microng/cm3 actidione discontinues the reproduction of the most virulent strain 2 when the antibiotic was added immediately after the adsorption of the virus on the cells. The decrease in the virulence of the virus strain was associated with the decrease in the concentration of the antibiotic needed for the inhibition of its propagation. Thus, the reproduction of the more slightly virulent strain 10 was fully inhibited at actidione concentration of 0.75 microng/cm3, while that of the avirulent strain MK was discontinued at 0.4 microng/cm3. The preliminary cultivation of the cells with 1 microng/cm3 actidione for 24 hours and the adsorption of the virus on the cells jointly with actidione showed no effect on the vitality of the virus particles.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D003513:Cycloheximide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006564:Herpesviridae / Q000187:drug effects*; D011558:Herpesvirus 1, Suid / Q000187:drug effects*; D013997:Time Factors; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D003513:Cycloheximide
Deistvieto na aktidiona vurkhu razmnozhenieto na virusa na bolestta na Aueski