[Correlation of membrane-bound and free ribosomes in normal rat liver, Zajdela hepatoma rat liver and ascite cells proper].
The content of membrane-bound ribosomes in normal rat liver cells is 3 times as high as compared to that of free ribosomes. (K=membrane-bound ribosome RNAs divided by free ribosome RNAs=3, the opposite effect being observed in case of ascites hepatoma cells. A considerable increase in the free ribosome fraction in the liver of hepatoma-bearing rats occurs by the sixth day due to a decrease in the content of hepatoma-bearing rats occurs by the sixth day due to a decrease in the content of membrane-bound ribosomes (K=0.6). Similar, but less-pronounced changes were observed in liver cells of control animals after 48-hour starvation  (K=0.9), simulating the condition occurring during the last days of tumour animals' life. Thus, changes in the rativ of membrane-bound to free ribosomes in liver during the ascites tumour growth are probably specifics and are not only due to anorexia in Zajdela hepatoma animals.
D000818:Animals; D000855:Anorexia / Q000473:pathology; D001202:Ascitic Fluid / Q000166:cytology; D006528:Carcinoma, Hepatocellular / Q000648:ultrastructure*; D008099:Liver / Q000648:ultrastructure*; D008113:Liver Neoplasms / Q000648:ultrastructure*; D008566:Membranes / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000648:ultrastructure; D051381:Rats; D012270:Ribosomes / Q000648:ultrastructure*; D013217:Starvation / Q000473:pathology
Soothoshenie membranosviazannykh i svobodnykh ribosom v pecheni zdprpvulj krys, krys s astsitnoĭ gepatomoĭ zaĭdela i v samikh astsitnykh kletkakh