Elimination of Proteus mirabilis 51Cr endotoxin from the liver in rats.
Using isotope methods, elimination of the endotoxin of Proteus mirabilis labeled with chromium (CrEPm) from the liver of rats was studied. The following studies were carried out: intravital exploration of the liver with a scintillation probe, measurements of radioactivity of organs and excreted urine and stools, scrintigraphy of the liver, binding of CrEPm by subcellular fractions of hepatocytes, and the influence of selected drugs (polymyxin and hydrocortisone) on elimination of CrEPm from the liver and organelles of hepatocytes.
D000818:Animals; D002860:Chromium Radioisotopes; D004731:Endotoxins / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011113:Polymyxins / Q000494:pharmacology; D011513:Proteus mirabilis; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism
D002860:Chromium Radioisotopes; D004731:Endotoxins; D011113:Polymyxins; D006854:Hydrocortisone