title: [Mechanism of action and clinical effectiveness of the new Soviet-made drug parmidin in the treatment of arteriosclerosis and ischemic heart disease].
abstract: The pharmacodynamics and efficacy of the new Soviet drug parmidin depending on the state of the coronary reserve are discussed on the basis of the results of observation over 176 patients suffering from chronic ischemic heart disease with affection of the peripheral arteries of the lower extremities. The activity of the drug in patients with atherosclerotic and diabetic affection of the arterial vessels is shown. The pharmacokinetics of parmidin in patients after the administration of a single 1.0 g dose was studied by determining its content in blood and urine 1, 2, 4, 8, 12, and 24 hours later. The effect of parmidin on the blood kinin system in patients with chronic ischemic heart disease was studied.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors; D007611:Aprotinin; D001120:Arginine / Q000031:analogs & derivatives; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D001549:Benzamides; D001777:Blood Coagulation / Q000187:drug effects; D002219:Carbamates / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004792:Enzyme Precursors / Q000037:antagonists & inhibitors; D004950:Esterases / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D007704:Kininogens / Q000037:antagonists & inhibitors; D001121:Lysine Carboxypeptidase / Q000037:antagonists & inhibitors; D008297:Male; D008875:Middle Aged; D011727:Pyridinolcarbamate / Q000008:administration & dosage / Q000627:therapeutic use*; D014586:USSR
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D001549:Benzamides; D002219:Carbamates; D004792:Enzyme Precursors; D007704:Kininogens; D011727:Pyridinolcarbamate; D007611:Aprotinin; D001120:Arginine; D004950:Esterases; D001121:Lysine Carboxypeptidase
vernacular_title: O mekhanizme deĭstviia i klinicheskoĭ effektivnosti novogo otechestvennogo preparata parmidina u bol'nykh aterosklerozom i ishemicheskoĭ bolezn'iu serdtsa.