Inhibition of the biologic effects of endotoxin on neutrophils by polymyxin B sulfate.
Polymyxin B sulfate diminished the endotoxin-mediated release of human blood neutrophil lysosomal enzymes. Similarly, this antibiotic reduced the endotoxin-induced increase in the neutrophil hexose monophosphate pathway activity as measured by the release of 14CO2 from [l-14C]glucose. Although these effects were seen with therapeutically attainable levels of polymyxin B sulfate, they could not be demonstrated when the cell-endotoxin interaction preceded treatment with polymyxin B sulfate.
D004731:Endotoxins / Q000494:pharmacology*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D009504:Neutrophils / Q000187:drug effects*; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*
D004731:Endotoxins; D011113:Polymyxins; D011112:Polymyxin B