[Chromosomes of 7 transplantable lines of macaque and pavian hematopoietic cells producing herpesvirus type EBV and oncornavirus type C].
Karyotypes of Su-1, Su-2, KMMA-1, and KMMA-2 (producing oncornavirus C-type), and KMPG-1, SPF-2, and SPG-3 (producing HSV, a virus of EBV type) cell lines were studied in the time course. The lines were derived from hemopoietic cells of brown macaques and baboons bearing lymphomas. Some of the lines had a paradiploid-pseudodiploid karyotype, another part aneuploid type. The selectivity of structural and numerical abnormalities of chromosomes 1, 9, 10, 11, 12, 13, 15, 18, and 20 was detected indicating a certain specificity of karyotype changes upon malignization and transformation. The number of poorly and moderately differentiating chromosomes in aneuploidy was confirmed by greater variability as compared with well-differentiating chromosomes. No parallelism between the karyotype change pattern and the type of virus produced (C or EBV) could be found thus far.
D000818:Animals; D001853:Bone Marrow; D002460:Cell Line; D002875:Chromosomes; D000882:Haplorhini; D004854:Herpesvirus 4, Human; D007621:Karyotyping; D008251:Macaca; D008297:Male; D010215:Papio; D011003:Ploidies; D012190:Retroviridae; D013154:Spleen
Izuchenie khromosom semi perevivaemykh linii krovetvornykh kletok makak i pavianov, produtsiruiushchikh virus gerpesa tipa EBV i onkornavirus tipa C.