[Role of adrenergic structures of the central nervous system in altering the function of the hypothalamo-hypophyseo-adrenal system in exogenous hyperthermia].
Subcutaneous injection of chlorpromazine to rats caused a lesser increase in body temperature and a higher content of the corticotropin-releasing factor (CRF) in the hypothalamus and the ACTH in the hypophysis under conditions of exogenous hyperthermia. The ascorbic acid content in the adrenal glands decreased in the same way as in the animals overheated without any chlorpromazine. There was no significant change in the weight of the adrenal gland. A conclusion was drawn on the participation of the central adrenergic structure in the regulation of the synthesis or the secretion of the CRF.
D000311:Adrenal Glands / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002746:Chlorpromazine; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D005334:Fever / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D009929:Organ Size; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D001205:Ascorbic Acid; D002746:Chlorpromazine
Znachenie adrenergicheskikh struktur tsentral'noĭ nervnoĭ sistemy v izmenenii funktsii gipotalamo-gipofizarno-nadpochechnikovoĭ sistemy pri ékzogennoĭ gipertermii