[Myocardial cell adenyl cyclase activity and the effect of thyrocalcitonin].
The thyrocalcitonin (TCT) effect under influence of some factors affecting the activity of membrane adenylcyclase (AC) of the ventricle myocardial cells in cold-blooded animals, was studied. The TCT positive inotropic effect is intensified by decrease in the potassium concentration in the medium, by blockade of alpha-adrenoreceptors with phentolamine, and inhibited by increase in the potassium concentration and blockade of beta-adrenoreceptors. The TCT action is preserved in presence of adrenaline.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D002116:Calcitonin; D011433:Propranolol; D000262:Adenylyl Cyclases; D002118:Calcium; D004837:Epinephrine; D010646:Phentolamine
Aktivnost' adeniltsiklazy miokardial'nykh kletok i éffekt tirokal'tsitonina