[Reproduction, morphogenesis and immunobiological properties of Aujeszky's disease virus commercially cultured in a suspension of poultry embryo explants].
The results of the study of reproduction, morphogenesis, and immunogenic properties of Aujeszky's disease virus (ADV) cultivated on an industrial scale in chick, duck and quail embryo explant suspensions are presented. A method for production of vaccine and virulent ADV strains with the activity of at least 7.5 log TCD50/ML in tanks of 5, 50, and 100 1 capacity was developed. A relationship between virion morphology and duration of cultivation was established. For ADV cultivated for 70 hours, a direct relationship between infectivity and immunogenicity was demonstrated.
D000818:Animals; D002642:Chick Embryo; D003470:Culture Media; D046508:Culture Techniques; D004306:Dose-Response Relationship, Immunologic; D004372:Ducks; D006564:Herpesviridae / Q000502:physiology*; D011558:Herpesvirus 1, Suid / Q000276:immunology / Q000502:physiology*; D009024:Morphogenesis; D011784:Quail; D013535:Suspensions; D013997:Time Factors; D014765:Viral Vaccines / Q000302:isolation & purification; D014779:Virus Replication
D003470:Culture Media; D013535:Suspensions; D014765:Viral Vaccines
Reproduktsiia, morfogenez i immunobiologicheskie svoĭstva virusa bolezni Aueski pri promyshlennom kul'tivirovanii v suspensii éksplantatov émbrionov ptits.