[Changes in plasma level of corticotropin after intravenous injection of metyrapone. Value of this test in pituitary pathology].
The Metyrapone was given, the morning, in perfusion intravenous of saline serum over 2 hours. A.C.T.H. levels were determined before and at 2, 4, 8 and 24 hours. Sixteen normal subjects adults served on controls with 1 g of Metyrapone. Sixteen other normal subjects with 2 g of Metyrapone are best responses. With this maximum dose 2 g were studied nine hypophysal adenomas with three low responses, three normal and three high responses; thirteen hypophysectomised subjects with very low peak value at 4 hours, and only two responses higher than the controls, five Cushing's syndromes with variable responses. The I.V. Metyrapone test seems to offer several advantages: it eliminates the questions about gastro-intestinal absorption of Metyrapone (oral) and the difficulties of urine collection. With the A.C.T.H. dosage on 4 hours, this is a rapid test able to put in combination other hypophysal tests.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002986:Clinical Trials as Topic; D003480:Cushing Syndrome / Q000175:diagnosis; D004361:Drug Tolerance; D006801:Humans; D007016:Hypophysectomy; D007275:Injections, Intravenous; D008722:Methods; D008797:Metyrapone / Q000494:pharmacology; D008875:Middle Aged; D010900:Pituitary Diseases / Q000175:diagnosis*; D010911:Pituitary Neoplasms / Q000175:diagnosis
D000324:Adrenocorticotropic Hormone; D008797:Metyrapone
Variations du taux plasmatique d'hormone corticotrope après injection intraveineuse de métyrapone. Intérêt de ce test en pathologie hypophysaire