title: Ergoline derivatives with oral, prolonged, alpha-adrenolytic activity.
abstract: The alpha-adrenolytic activity of 1-methyl-10-methoxydihydrolysergol 2-(3,5-dimethyl)pyrrolcarboxylate (XV, formula II) is, both in vitro and parenterally, quite similar to that of dihydroergotamine. By oral route the new compound is more active, and longer lasting than dihydroergotamine.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003692:Delayed-Action Preparations; D004087:Dihydroergotamine / Q000494:pharmacology; D004873:Ergolines / Q000138:chemical synthesis*; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008297:Male; D009530:Nicergoline / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013329:Structure-Activity Relationship; D013565:Sympatholytics / Q000138:chemical synthesis*
chemical_list: D003692:Delayed-Action Preparations; D004873:Ergolines; D011942:Receptors, Adrenergic, alpha; D013565:Sympatholytics; D004087:Dihydroergotamine; D009530:Nicergoline