Action of dihydroaflatoxins on rat liver mitochondria. 1. Membrane-dependent osmotic and redox effects of aflatoxins B2 and G2.
Membrane-dependent osmotic and redox effects of two dihydroaflatoxins (aflatoxin B2 and G2) on isolated rat liver mitochondria were investigated. These toxins did not cause any marked swelling, inhibit any ATP induced contraction or stimulate ATPase activity of mitochondria at concentrations within the range 1--2 x 10(-6) M. Redox measurements on the respiratory chain showed that both toxins inhibited respiration between cytochrome c and the terminal oxygen. The significance of these findings in relation to the differential toxicity of the aflatoxins is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008566:Membranes / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D009995:Osmosis / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
D000348:Aflatoxins; D003579:Cytochrome Reductases; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases; D002118:Calcium