Cytotoxic interactions of virus specific effector cells with virus infected targets of different cell type.
The action of Sendai virus specific cytolytic T lumphocytes (CTL) against Sendai virus infected macrophages was found to be H-2 restricted while Sendai virus infected cell lines, including fibroblasts and tumour cells, were lysed across the H-2 barrier to some extent. The properties of the Meth-A tumour cell, which was resistant to lysis by allogenic killer cells was investigated. Sendai virus specific CTL failed to kill Sendai virus infected Meth-A cells but after vaccinia virus infection these target cells were susceptible to lysis by vaccinia virus specific CTL.
D000818:Animals; D000956:Antigens, Viral; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000276:immunology; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology
D000956:Antigens, Viral; D006649:Histocompatibility Antigens