Benign hepatic tumors and oral contraceptive pills.
In order to consider possible environmental factors related to the development of benign hepatic tumors, all reports of this disorder in the case records of five different hospitals in Rochester, New York, during the past 10 years were reviewed. Seven patients with benign hepatic tumors of the liver and two with peliosis hepatis were identified. Among the seven with a benign hepatic tumor, four were women currently receiving oral contraceptives; one had been receiving this medication in the past, and two had no history of exposure to any steroid whatsoever. The two patients with peliosis hepatis were receiving long-term androgenic anabolic steroids. Dilated, thin-walled vessels and vascular spaces were a more prominent feature of the tumor seen in four patients receiving oral contraceptive pills. It is emphasized in this report that benign hepatic tumors do occur in men and in patients with cirrhotic liver without the use of any kind of steroids.
D000328:Adult; D000368:Aged; D000728:Androgens / Q000009:adverse effects; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000728:Androgens; D003276:Contraceptives, Oral