C-type and intracisternal A-type virus particles during epidermal carcinogenesis by tobacco smoke condensate in BALB/c mice.
Electron microscopic observations of sequential stages of skin carcinogenesis induced by tobacco smoke condensate (SC) and a cyclohexane fraction of tobacco smoke condensate (G) revealed an increase in incidence of intracisternal A particles within the epidermal cells. Tumours induced by SC also contained C-type particles, but these were not seen in G-induced tumours or after irritant or solvent treatment. There was no evidence of an increase in intracisternal A particles after irritant or solvent treatment. A direct relationship between the proliferation of A particles and neoplastic growth of BALB/c mouse epidermis appears likely. The data suggest possible activation of a latent C-type virus by SC.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000382:microbiology / Q000648:ultrastructure; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009858:Oncogenic Viruses / Q000302:isolation & purification*; D012190:Retroviridae / Q000302:isolation & purification*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000382:microbiology*; D012907:Smoking