Screening of human brain tumors for SV40-related T antigen.
A series of 39 human brain tumors has been screened for the presence or absence of SV40-related T antigen by the direct and indirect immunoperoxidase methods. Two tumors of ependymal origin (malignant ependymoma, choroid plexus papilloma) revealed markedly positive nuclear staining for T antigen both in vivo and in vitro. The relationship of these tumors to their experimental counterparts inducible by recent human papovavirus isolates is discussed.
D000956:Antigens, Viral / Q000032:analysis; D001932:Brain Neoplasms / Q000276:immunology*; D002551:Cerebral Ventricle Neoplasms / Q000276:immunology; D002831:Choroid Plexus; D003168:Complement Fixation Tests; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013539:Simian virus 40 / Q000276:immunology*
D000956:Antigens, Viral