The role of cyclic adenosine 3',5'-monophosphate (cAMP) in the mechanism of action of tricyclic antiderpressants.
In the course of investigations on experimental arterial hypertension in rats, it has been stated, that imipramine prevents the development of hypertension and that is simultaneously causes an accumulation of cAMP in the vessel walls. The relationship between the two phenomena has been discussed.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D001808:Blood Vessels / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006973:Hypertension / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism; D007668:Kidney / Q000098:blood supply; D008026:Ligation; D008297:Male; D051381:Rats; D013997:Time Factors
D000242:Cyclic AMP; D007099:Imipramine