title: Properties of the erythrocyte receptors for influenza C virus.
abstract: Properties of the receptor for influenza C virus were studied. Although the receptor for influenza C virus on chicken erythrocytes was destroyed by the homologous virion, neuraminidase activity could not be detected in any of the influenza C virus strains tested. The receptor activity of chicken erythrocytes for influenza C virus was diminished by formaldehyde treatment but not by periodate oxidation. There was a considerable variation in the pattern and the titer of hemagglutination of influenza C virus when human erythrocytes of different blood types were used; the virus agglutinated most type B erythrocytes but not type A erythrocytes. By using human type B erythrocytes, differences among strains of influenza C virus in the hemagglutinating activity were also demonstrated. These results showed that both the receptor for and the receptor-destroying activity of influenza C virus were completely different from those of influenza A or B virus and also that carbohydrates were not involved in the receptor for influenza C virus.
mesh_terms: D000017:ABO Blood-Group System; D000818:Animals; D002645:Chickens; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D005557:Formaldehyde / Q000494:pharmacology; D006387:Hemagglutination, Viral / Q000187:drug effects; D006801:Humans; D009439:Neuraminidase / Q000378:metabolism; D009975:Orthomyxoviridae / Q000201:enzymology / Q000276:immunology*; D010504:Periodic Acid / Q000494:pharmacology; D011991:Receptors, Virus / Q000187:drug effects / Q000276:immunology*
chemical_list: D000017:ABO Blood-Group System; D011991:Receptors, Virus; D010504:Periodic Acid; D005557:Formaldehyde; D009439:Neuraminidase