title: Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach.
abstract: The signet-ring cells seen in gastric carcinoma of the diffuse type were studied by light and electron microscopy. A classification of these cells into Types A, B and C was developed, based on intracellular mucous granules, nuclei and organelles, and be reactions to PAS and Alcian-blue staining. The gradual transition of type A cells to Type B and the subsequent change of Type B to Type C suggest successive stages in maturation. These cells, especially those of Type B, resemble the mucous neck cells of the corpus and the glands of the pylorus.
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D002293:Adenocarcinoma, Scirrhous / Q000473:pathology; D002454:Cell Differentiation; D002467:Cell Nucleus; D006801:Humans; D008854:Microscopy, Electron; D013274:Stomach Neoplasms / Q000473:pathology*