[Disorder of the regulation of metabolic processes in coronary arteriosclerosis].
The activity of adenylcyclase was determined in the thrombocytes of 54 male patients with Stage III coronary atherosclerosis. In 34 patients without signs of ischaemic heart disease the activity of adenylcyclase and phosphodiestherase and the amount of cortisol were determined in blood plasma. In 40 rabbits the same enzymes activity was determined in the thrombocytes and lipid tissue, as well as the amount of lipoproteins of low and very low density was determined in blood plasma prior to and following cortisol administration. The results of clinical and experimental studies have demonstrated that cortisol affects the activity of the adenylcyclase system enzymes in the thrombocytes and lipid tissue, as well as the transformation of lipoproteins in blood plasma.
D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D003327:Coronary Disease / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006949:Hyperlipidemias / Q000201:enzymology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010727:Phosphoric Diester Hydrolases / Q000097:blood*; D010974:Platelet Aggregation; D011817:Rabbits
D008074:Lipoproteins; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006854:Hydrocortisone
Narushenie reguliatsii obmennykh protsessov u bol'nykh koronarnym aterosklerozom