Herpesvirus hominis type 2 meningoencephalitis following renal transplantation.
Herpesvirus hominis (HVH) type 2 meningoencephalitis, confirmed by isolation of the virus from cerebrospinal fluid and brain biopsy specimens, is described in a 44 year old man following renal transplantation. An HVH type 2 genital infection developed two weeks after renal transplantation, which was followed by meningoencephalitis 10 days later. Subsequently an intracerebral hemorrhage developed with evidence of diffuse vasculitis on arteriography. In a second transplant patient a similar clinical syndrome also developed after an HVH type 2 genital infection, but viral studies were not made to confirm the etiology of the meningoencephalitis. HVH has been recognized as a cause ot mucocutaneous diseases in  recipients of renal transplants, but involvement of the central nervous system has not been reported.
D000328:Adult; D001921:Brain / Q000382:microbiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008590:Meningoencephalitis / Q000209:etiology* / Q000382:microbiology; D018139:Simplexvirus / Q000302:isolation & purification; D014184:Transplantation, Homologous / Q000009:adverse effects