title: Distribution and excretion of 2,4,5,2',4',5'-hexabromobiphenyl, the major component of Firemaster BP-6.
abstract: The intestinal absorption, distribution, and excretion of the major component of Firemaster BP-6,2,4,5,2',4',5'-hexabromobiphenyl, has been studied in the male rat. This polybrominated biphenyl was readily absorbed from the intestine, initially distributed throughout the body, and eventually stored primarily in the adipose tissue, was not subject to appreciable metabolism, and was excreted almost exclusively in the feces and at a very slow rate. Approximately 90% of an oral dose was absorbed from the intestine, and extrapolation of the rate of excretion to infinity indicates that less than 10% of the total dose would ever be excreted.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001713:Biphenyl Compounds / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005411:Flame Retardants / Q000008:administration & dosage / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D011075:Polybrominated Biphenyls / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D001713:Biphenyl Compounds; D005411:Flame Retardants; D011075:Polybrominated Biphenyls