[Chemical and pharmacologic study on pyran derivatives. IX. Synthesis of 2-dialkylaminochromones].
Under suitable conditions the reaction of phenol and N,N-dialkylethoxycarbonylacetamides, in the presence of phosphorus oxychloride, resulted in the formation of 2-dialkylaminochromones. In a similar manner, variously substituted phenols afforded 2-dialkylaminochromones with substituents in different positions of the benzene ring. Pharmacological screening of all these compounds showed that they markedly affect the CNS, activity being mainly excitatory. Decreased activity was shown by compounds with particular substituents in the positions 6,7,8 among which two products [(V e) - K 12440, (V s) - K 12420] have weak but clear anticonvulsant effect.
D000818:Animals; D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D002490:Central Nervous System / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D004748:Entamoeba histolytica / Q000187:drug effects; D051379:Mice; D009069:Movement Disorders / Q000139:chemically induced; D051381:Rats; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D002867:Chromones
Ricerche chimiche e farmacologiche su derivati piranici. Nota IX. Sintesi di 2-dialchilamminocromoni.