Changes in the activities of nucleoside triphosphatases and nucleoside kinases in Vero cells infected with Simian virus 40.
Changes in the activities of three enzymes involved in nucleotide metabolism were studied following infection of Vero cells with SV40. The results showed that SV40 infection enhanced the activities of uridine phosphokinase and UMP phosphokinase involved in nucleotide synthesis and suppressed the activity of nucleoside triphosphatases involved in nulceotide degradation. These SV40-induced enzyme activity changes probably served to somehow increase the quantity of nucleotides for virus proliferation.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D000882:Haplorhini; D007668:Kidney; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D011755:Pyrophosphatases / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D013539:Simian virus 40; D014500:Uracil Nucleotides; D014541:Uridine Kinase / Q000378:metabolism*
D014500:Uracil Nucleotides; D012313:RNA; D010770:Phosphotransferases; D014541:Uridine Kinase; D009703:Nucleoside-Phosphate Kinase; D011755:Pyrophosphatases