Studies on the correct quantitative relations of antigen components in mono-, bi- and trivalent foot-and-mouth disease vaccine preparations.
Waldmann and frenkel type mono-, bi- and trivalent FMD vaccines, with different quantitative relations of the antigen components, were prepared and tested by the E, K and S index methods. Potency tests in adult mice showed that the antigen components of the bivalent vaccines are usually synergistic, but a 47-57% excess of antigen "O1" over the other two types is always required for a similar immunogenic action (E index value). For the same reason, the "O1" content of the trivalent vaccine should be as high as the total quantity of its other two components. Trivalent FMD vaccines in which the quantitative relations of the antigen components correspond with the proportions assessed as optimal in the mouse test prove also to be satisfactorily immunogenic in cattle in respect of all three components.
D000818:Animals; D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis*; D005537:Aphthovirus / Q000276:immunology*; D003168:Complement Fixation Tests; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains; D014765:Viral Vaccines / Q000592:standards*
D000956:Antigens, Viral; D014765:Viral Vaccines