Ependymomas, malignant tumors of pancreatic islets, and osteosarcomas induced in hamsters by BK virus, a human papovavirus.
BK virus (BKV), a human papovavirus, was inoculated iv into 3-week-old Syrian golden hamsters. Between 2 1/2 and 9 months after inoculation, 82% of the animals developed tumors. The induced neoplasms were ependymoma, carcinoma of the pancreatic islets, osteosarcoma, adenocarcinoma, angiosarcoma, angioma, lymphoma, and seminoma. Hypersecretion of insulin, glucagon, C-peptide, and calcitonin was detected in tumors of pancreatic islets. BKV etiology of tumors was supported by the following evidence: 1) No tumors with BKV-specific markers appeared in animals given injections of buffer, animals inoculated with BKV neutralized by anti-BKV-specific serum, or uninoculated controls; 2) BKV tumor (T) antigen was detected by immunofluorescence and complement fixation tests in tumors of animals inoculated with infectious BKV and in transplanted tumors; 3) antibodies to BKV T-antigen were detected in sera of animals bearing primary or transplanted tumors; 4) BKV could be activated by Sendai virus-mediated fusion of neoplastic cells with susceptible Vero cells; and 5) no endogenous hamster oncornaviruses were found in tumors.
D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral; D001739:BK Virus / Q000276:immunology; D001786:Blood Glucose / Q000378:metabolism; D006224:Cricetinae; D004806:Ependymoma / Q000209:etiology* / Q000473:pathology; D006728:Hormones / Q000097:blood; D007515:Islets of Langerhans; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology; D012516:Osteosarcoma / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000097:blood / Q000209:etiology*; D012190:Retroviridae / Q000302:isolation & purification; D012513:Sarcoma, Experimental / Q000209:etiology*; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000209:etiology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D001786:Blood Glucose; D006728:Hormones