title: The pathogenesis of infectious avian encephalomyelitis. 1. The effect of the age of the chicken and the route of administration of the virus.
abstract: The age of the chicken at the time of infection with infectious avian encephalomyelitis virus (IAEV) and the route of the administration of the virus had a marked effect on the development of the clinical disease. Chickens given the virus by intramuscular, intraperitoneal and oral routes exhibited a decreased susceptibility to development of clinical disease with increasing age. Irrespective of age, chickens were consistently susceptible to intracerebral inoculation of IAEV. Chickens infected with the virus at 1-, 7- and 14-days of age developed lower neutralising antibody titres to IAEV than chickens infected at 21 and 28 days. A relationship between the ability to produce specific neutralising antibody to IAEV and susceptibility to the development of clinical disease is discussed.
mesh_terms: D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain; D002645:Chickens; D001350:Encephalomyelitis Virus, Avian / Q000276:immunology; D004769:Enterovirus Infections / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D011201:Poultry Diseases / Q000209:etiology* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral