Trophoblastic tumour, oral contraceptive therapy and pregnancy associated alpha2-glycoprotein (PAAG), case report.
Pregnancy associated alpha2-glycoprotein (PAAG) and human chorionic gonadotrophin (HCG) levels were studied in a patient with an invasive mole who was being treated with cytotoxic drugs and oral contraceptives. Both the PAAG and HCG levels fell during cytotoxic drug treatment while oral contraceptives caused a rise in PAAG concentrations. A relation between oestrogen-induced PAAG and prolonged survival of trophoblastic tumour is proposed.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000652:urine; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000097:blood* / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000097:blood*
D006063:Chorionic Gonadotropin; D003276:Contraceptives, Oral; D006023:Glycoproteins; D008727:Methotrexate