[Preparation and pharmacological activity of N6, 02-dipivaloyl-cyclic AMP].
The synthesis of N6,O2'-dipivaloyl-cyclic AMP is described with some pharmacological tests made in comparison with the dibutyryl homolog. The two compounds proved equally active in increasing glycemia in the rabbit whereas the dipivaloyl derivative is less effective in counteracting contractions induced by imidazole in the isolated guinea-pig trachea.
D000818:Animals; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006168:Guinea Pigs; D010421:Pentanoic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits; D014132:Trachea / Q000187:drug effects
D001786:Blood Glucose; D010421:Pentanoic Acids; D000242:Cyclic AMP
Preparazione e attività farmacologiche del N6,O2'-dipivaloil-AMPc.