Metabolic effects of some antibilharzial drugs inhibition of citrate oxidation by Bilharcid.
Bilharcid inhibited citrate oxidation and the inhibition was decreased by time. The inhibition is not restored or reduced by increasing citrate concentration. NAD stimulated citrate oxidation in the presence of Bilharcid. Cysteine slightly stimulated citrate oxidation, while ATP had no effect. Addition of citrate before Bilharcid protected the enzyme against the inhibitory action of the drug.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D000965:Antimony / Q000494:pharmacology*; D002951:Citrates / Q000378:metabolism* / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D066298:In Vitro Techniques; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors; D008099:Liver / Q000201:enzymology; D009243:NAD / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats
D002951:Citrates; D009243:NAD; D000255:Adenosine Triphosphate; D000965:Antimony; D007521:Isocitrate Dehydrogenase; D003545:Cysteine