[Comparative characteristics of the lipoproteins of the human vascular wall and blood plasma].
Electrophoresis in the polyacrylamide gel and ultracentrifugation with a multistage density gradient demonstrated virtually the whole of the blood plasma lipoproteids spectrum to be contained in the human aortal wall. An immunological identity of the whole beta- and alpha-lipoproteids and also of their individual apoproteins in the aortal wall and blood plasma was ascertained. Moreover, the ratio of etherified cholesterol/total cholesterol in the vascular and plasmatic lipoproteids proved to be quiet close. In determining the content of the summary pre-beta-and beta-lipoproteids in the aortal wall the quantity of the said lipoproteids in atherosclerotic lesions was found several times as high as in a normal aorta, whereas the lipoproteids concentration in an intact aortal wall correlated with the intensity of atherosclerosis in the same aorta. The data obtained bear evidence to a plasmatic origin of lipoproteids in the vascular wall and to their important role in atherogenesis.
D000328:Adult; D000367:Age Factors; D001013:Aorta, Thoracic / Q000032:analysis; D001808:Blood Vessels / Q000032:analysis*; D002784:Cholesterol / Q000032:analysis; D006801:Humans; D008074:Lipoproteins / Q000032:analysis*; D008075:Lipoproteins, HDL / Q000032:analysis; D008077:Lipoproteins, LDL / Q000032:analysis; D008079:Lipoproteins, VLDL / Q000032:analysis; D008875:Middle Aged; D014280:Triglycerides / Q000032:analysis; D014682:Vena Cava, Inferior / Q000032:analysis
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol
Sravnitel'naia kharakteristika lipoproteidov sosudistoĭ stenki i plazmy krovi cheloveka