title: Studies on cytochrome C. XII. Synthesis of the protected undecapeptide (sequence 66-76) and pentadecapeptide (sequence 66-80) of horse heart cytochrome c.
abstract: This paper is part of a series on synthesis of suitably protected peptides covering the 66-104 sequence of horse heart cytochrome c. It describes the preparation, by conventional procedures, of a partially protected N alpha-benzyloxycarbonyl-undecapeptide hydrazide corresponding to the sequence from 66 to 76 (Fragment F), which represents a building block for the synthesis of the entire 66-104 sequence. Moreover, the preparation is described of a partially protected pentadecapeptide corresponding to the sequence region 66 to 80, which represents the key peptide for the semisynthesis of the same COOH-terminal sequence utilizing the natural 81-104 N epsilon-trifluoroacetylated CNBr fragment.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003574:Cytochrome c Group / Q000032:analysis / Q000138:chemical synthesis*; D006736:Horses; D009206:Myocardium / Q000032:analysis; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis
chemical_list: D003574:Cytochrome c Group; D010455:Peptides