[Diurnal rhythm of cell proliferation at the late stages of precancerous changes in the liver induced by ortho-aminoazo-toluene].
Orthoaminoazotoluol was administered to mice for a period of nine months. Circadian rhythms of mitotic activity and the number of the DNA-synthesizing cells were determined by autoradiography (with the use of 3H-thymidine) at the second (adenomatous nodes) and the third (primary hepatoma) stages of carcinogenesis in the developing tumours and the surrounding liver parenchyma. The listed structures proved to have a single-peak rhythm of mitotic activity with the maximum of mitoses at 4-7 a. m.; the labeled nuclei circadian rhythm was double-peaked with the maximum at 7 p. m. and 4 a. m. The mean 24-hour values of both indices at the second and third stages of hepatocarcinogenesis were much greater than in the surrounding non-tumour tissue of the liver.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology*; D002940:Circadian Rhythm; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D051379:Mice; D008938:Mitosis; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D009762:o-Aminoazotoluene
D009762:o-Aminoazotoluene
Sutochnye ritmy kletochnoĭ proliferatsii na pozdnykh stadiiakh predrakovykh izmeneniĭ pecheni, indutsirovannykh ortoaminoazotoluolom.