The effect of phosphonoacetic acid on the in vitro replication of varicella-zoster virus.
Phosphonoacetic acid (PAA) was found to inhibit in vitro varicella-zoster virus (VZV) replication. At 100 microng/ml, PAA blocked the development and spread of VZV cytopathology in both growing and contact-inhibited cultures. Formation of virus plaques by infected cells and cell-free virus was effectively blocked at concentrations as low as 25 microng/ml. The development of nuclear and cytoplasmic virus antigens was also inhibited by PAA. Inhibition by PAA suggests that VZV DNA replication, like that of other herpes-viruses, involves a virus-specific DNA polymerase.
D000085:Acetates / Q000494:pharmacology*; D000956:Antigens, Viral / Q000032:analysis; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000276:immunology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000085:Acetates; D000956:Antigens, Viral; D009943:Organophosphorus Compounds