[Effect of glucocorticoid hormones on nuclear RNA-polymerase activity and RNA metabolizability in rat skeletal muscles].
It has been found that in hypercorticism induced by a prolonged ACTH administration when protein synthesis is inhibited in the skeletal muscles the incorporation of Na2HP32O4 into muscle RNA intensifies by 30% and the RNA-polymerase activity of muscle nuclei is approximately twice as high. In the adrenalectomized rats 3 hours after a single hydrocortisone administration a sharp rise in the RNA-polymerase activity of the skeletal muscle nuclei is observed as well. Such an increase in RNA synthesis is suggested to be a response to the inhibition of protein synthesis through feedback mechanisms.
D000315:Adrenalectomy; D000308:Adrenocortical Hyperfunction / Q000139:chemically induced / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D005938:Glucocorticoids; D012313:RNA; D000324:Adrenocorticotropic Hormone; D012321:DNA-Directed RNA Polymerases
Vplyv hliukokortykoïdnykh hormoniv na RNK-polimeraznu aktyvnist' iader i obminiuvanist' RNK u skeletnykh m'iazakh shchuriv