Practolol inhibition of some salbutamol-induced metabolic and hormonal responses.
The effect of practolol (a selective beta1-adrenergic receptor blocking agent) on increased blood insulin, sugar, lactate and FFA and decreased blood phosphorus and potassium induced by salbutamol (a primarily beta2-adrenergic stimulant) was studied in 6 normal volunteers. Practolol abolished the rise of lactate and glucose, suggesting that changes in these parameters due to salbutamol are mediated by beta1-receptors. The rise of insulin and the fall of potassium were only partially inhibited, and the possible involvement of the beta2-receptors as well in these 2 cases cannot be ruled out. The decrease of phosphorus and the FFA rise were not affected and thus appear to be primarily dependent on beta2-receptors.
D000328:Adult; D000420:Albuterol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007773:Lactates / Q000097:blood*; D008297:Male; D010710:Phosphates / Q000097:blood*; D011188:Potassium / Q000097:blood*; D011217:Practolol / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D010710:Phosphates; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000420:Albuterol; D011188:Potassium; D011217:Practolol