Donation of N- or B-tropic phenotype to NB-tropic murine leukemia virus during mixed infections.
The IC isolate of Moloney murine leukemia virus (MuLV), which is NB-tropic, was grown in cells producing conditionally defective or defective virus particles derived from N- or B-tropic MuLV. The infectious MuLV that was then released was found to be sensitive to Fv-1 restriction but produced NB-tropic progeny upon passage. These results indicate that this NB-tropic MuLV can acquire sensitivity to Fv-1 restriction by phenotypic mixing with N- or B-tropic MuLV. It is thus suggested that NB-tropic MuLV is insensitive to Fv-1 restriction simply because it lacks the determinants of tropism.
D000818:Animals; D002460:Cell Line; D003673:Defective Viruses / Q000254:growth & development; D005796:Genes; D009052:Leukemia Virus, Murine / Q000254:growth & development*; D051379:Mice; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000254:growth & development*; D009154:Mutation; D010641:Phenotype; D013045:Species Specificity; D013696:Temperature; D014764:Viral Proteins; D014779:Virus Replication
D014764:Viral Proteins