Stimulation of longitudinal bone growth by hypophyseal hormones in the hypophysectomized rat.
The stimulating effect of different pituitary hormones on longitudinal bone growth was determined with tetracycline as intravital marker in hypophysectomized rats. Growth hormone was found to be the most effective growth stimulating pituitary hormone. At considerably higher doses, thyrotrophic hormone (TSH) and prolactin also showed growth stimulating pituitary hormone. At considerably higher doses, thyrotrophic hormone (TSH) and prolactin also showed growth stimulating activity. TSH exerts its effect via the production of thyroxine, whereas the growth stimulation by prolactin seems to be a direct effect of this hormone, similar to the effect of growth hormone. The LH, FSH, ACTH, MSH, vasopressin and oxytocin preparations did not stimulate longitudinal bone growth.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D002356:Cartilage / Q000254:growth & development; D004357:Drug Synergism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology; D007016:Hypophysectomy; D007986:Luteinizing Hormone / Q000494:pharmacology; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D010907:Pituitary Hormones / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013972:Thyrotropin / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology; D013977:Tibia / Q000254:growth & development; D014667:Vasopressins / Q000494:pharmacology
D010907:Pituitary Hormones; D014667:Vasopressins; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D009074:Melanocyte-Stimulating Hormones; D013974:Thyroxine