Role of the rel gene product in the control of cyclic adenosine 3',5'-monophosphate accumulation.
The presence of a relA mutant allele affects the kinetics of cyclic adenosine 3',5'-monophosphate accumulation during downshift from glucose to succinate. The nucleotide accumulates at the normal rate early in the downshift transition but continues to accumulate for a longer time in the relA mutant, leading to a two- to threefold excess by the end of the diauxic lag. Evidence is presented that this effect occurs independently of the accumulation of ppGpp.
D000483:Alleles; D000242:Cyclic AMP / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D006150:Guanine Nucleotides / Q000378:metabolism; D009154:Mutation; D014176:Protein Biosynthesis
D006150:Guanine Nucleotides; D000242:Cyclic AMP