Sitosterol in juvenile type II hyperlipoproteinemia.
The effect of beta-sitosterol on plasma lipids and lipoproteins was evaluated in a randomized double-blind cross-over trial in 15 children and adolescents with familial hypercholesterolemia over a period of 6 months. Twelve patients completed the study, with good adherence to drug intake. Sitosterol lowered the plasma total choelsterol by 6%, LDL cholesterol by 7% and HDL cholesterol by 15% (P less than 0.05). This insufficient response of total and LDL cholesterol and the marked fall of HDL cholesterol appears to advise against the use of beta-sitosterol granulate in juvenile type II hyperlipoproteinemia.
D000293:Adolescent; D000328:Adult; D001965:Bromides / Q000097:blood; D002648:Child; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000235:genetics*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D012855:Sitosterols / Q000097:blood / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D001965:Bromides; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D012855:Sitosterols; D014280:Triglycerides; D002784:Cholesterol