title: Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents.
abstract: A series of bisamidines of 2,6-diaminoanthraquinone was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. A number of compounds were found to have good activity against infections in both species.
mesh_terms: D000562:Amebiasis / Q000188:drug therapy*; D000563:Amebicides / Q000138:chemical synthesis; D000578:Amidines / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis / Q000627:therapeutic use*; D006224:Cricetinae; D004404:Dysentery, Amebic / Q000188:drug therapy; D004748:Entamoeba histolytica; D004749:Entamoebiasis / Q000188:drug therapy*; D005260:Female; D008101:Liver Abscess, Amebic / Q000188:drug therapy; D051381:Rats
chemical_list: D000563:Amebicides; D000578:Amidines; D000880:Anthraquinones