[Tumor growth and protein synthesis in mouse hepatoma 22A cells under antitumor effect of N-methyl-N-nitrosourea].
A single injection of N-methyl-N-nitrosourea results in simultaneous long-term inhibition of tumor growth and protein synthesis in mouse hepatoma 22a cells. These effects are tightly connected: onset of tumor regrowth starts only after a full recovery of the activity of the protein synthetic machinery of tumor cells.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism; D008770:Methylnitrosourea / Q000627:therapeutic use*; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D009607:Nitrosourea Compounds / Q000627:therapeutic use*
D009363:Neoplasm Proteins; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
Sintez belka i rost gepatomy 22a pri deĭstvii N-metil-N-nitrozomocheviny