Cerebral granular cell tumor (myoblastoma) in a dog: case report and literature review.
An infiltrative granular cell tumor (myoblastoma) occurred in the superficial parieto-occipital cortex of an ataxic 12-year-old dog. The neoplasm was characterized by cells with numerous small PAS-positive, diastase-resistant cytoplasmic granules. The neoplasm also had numerous cells with large globular PAS-positive bodies (angulate bodies). Ultrastructurally, the neoplastic cells were characterized by numerous homogenous electron-dense, sharply bounded granules and large pleomorphic, indistinctly bounded granules. The angulate bodies were composed of 8- to 10-nm fibrils, a few of which formed parallel arrays or tubule-like structures. This represents the first report of a granular cell tumor in the central nervous system of the dog.
D000818:Animals; D001932:Brain Neoplasms / Q000648:ultrastructure / Q000662:veterinary*; D002540:Cerebral Cortex / Q000648:ultrastructure; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000648:ultrastructure / Q000662:veterinary*; D009778:Occipital Lobe / Q000648:ultrastructure; D010296:Parietal Lobe / Q000648:ultrastructure