Relations between prostaglandin E2, F2alpha, and cyclic nucleotides levels in rat brain and induction of convulsions.
Fully convulsant doses of pentamethylenetetrazole cause marked increase in rat brain cortical PGF2alpha, PGE2, cGMP and cAMP during seizures, whereas subconvulsant doses cause an increase of rat brain cortical PGF2alpha without affecting the other biochemical parameters considered. Rat cerebellar prostaglandins were not modified by the convulsant agent at either dosage.
D000818:Animals; D001393:Azoles / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000378:metabolism; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism*; D006152:Cyclic GMP / Q000032:analysis / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011458:Prostaglandins E / Q000032:analysis / Q000378:metabolism*; D011460:Prostaglandins F / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology*
D001393:Azoles; D011458:Prostaglandins E; D011460:Prostaglandins F; D013777:Tetrazoles; D000242:Cyclic AMP; D006152:Cyclic GMP