Immunostimulation of cytomegalovirus-transformed cells and its inhibition by blocking sera.
Spleen cells cytotoxic at high effector cell: target cell ratios specifically enhanced target cell survival at low ratios. Both cytotoxicity and immunostimulation could be specifically blocked by sera from tumor-bearing or virus-sensitized hosts. The results suggested that serum factors participate in the regulation of the cell-mediated immune response.
D000818:Animals; D001769:Blood; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D003587:Cytomegalovirus; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology