[Sodium diethyldithiocarbamate is a stimulating agent of immunity].
A single dose of DTC was administered, in a dose-range from 0.6 mg/kg to 25 mg/kg, to mice immunized with 10(8) sheep red cells (SRC). All doses strongly enhanced plaque-forming spleen cell (PFC) responses, when given either 18 h before, simultaneously to, 6 h or 24 h after SRC immunization. However, the higher levels of immunostimulation were attained by DTC doses above 5 mg/kg. DTC-induced immunopotentiation was not accompanied by untoward effects, such as acute toxicity, splenomegalia or modifcations in counts of viable spleen lymphocytes.
D000818:Animals; D004050:Ditiocarb / Q000494:pharmacology*; D007109:Immunity / Q000187:drug effects*; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D013154:Spleen / Q000187:drug effects; D013268:Stimulation, Chemical; D013859:Thiocarbamates / Q000494:pharmacology*
D007136:Immunoglobulins; D013859:Thiocarbamates; D004050:Ditiocarb
Le diéthyldithiocarbamate de sodium est un stimulant de l'immunité.