Antilipidemic drugs. Part 6: LF 178 in man. A preliminary note on a multicenter investigation bearing on 393 subjects with pure or mixed forms of hyperlipidemia.
A total of 393 patients affected by different foms of hyperlipoproteinemia have been treated for up to 12 months or more with a daily dose of 200-400 mg of isopropyl-4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF 178; procetofene; Lipanthyl). In pure hypercholesterolemia (IIa) the mean depression of cholesterol exceeded 26% and the drug induced degree of normalization was 85%. In mixed hypercholesterolemia (IIa) cholesterol was depressed by 23% and triglycerides by approximately 40%. In major affections of hypercholesterolemia (cholesterol > 3.5 gll) the mean induced depression exceeded 30%. Pure hypertriglyceridemia (IV) was strongly affected by the drug LF 178 induced a mean depression of triglycerides exceeding 60% after 6 months of treatment. In all cases the antilipidemic effect was fast and well sustained...
D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000235:genetics*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D011422:Propionates / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011422:Propionates; D014280:Triglycerides