title: Immunoglobulin inclusions in non-Hodgkin's lymphomas.
abstract: The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin's lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG (k) in two cases and a polyclonal pattern in the third case, where the tumor evolved from a reactive lesion. Unusual cytoplasmic inclusions were observed in the neoplastic cells of two patients with follicular center cell lymphoma. In one case large globular structures lacking a distinct limiting membrane were seen, while the cells of the other patient contained "signet-ring-like" vacuoles filled with microvesicles. Both were PAS-negative and showed monoclonal immunglobulin staining. In two other cases PAS-positive intranuclear inclusions consisting of monoclonal immunoglobulin IgM(k) could be demonstrated. The possible significance of these findings in B-lymphocyte derived neoplasms is discussed.
mesh_terms: D000328:Adult; D000368:Aged; D003593:Cytoplasm / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007136:Immunoglobulins; D002479:Inclusion Bodies / Q000276:immunology / Q000648:ultrastructure*; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000276:immunology / Q000473:pathology
chemical_list: D007136:Immunoglobulins