Enzyme-accelerated hydrolysis of polyglycolic acid.
In a preliminary study of the enzyme-polymer interactions, the role of 15 enzymes in the in vitro hydrolysis of polyglycolic acid has been investigated. Carboxypeptidase A, alpha-chymotrypsin, clostridiopeptidase A and ficin increase the rate of hydrolysis of this synthetic polymer, illustrating the ability of enzymes to influence polymer degradation.
D001672:Biocompatible Materials; D001963:Bromelains / Q000494:pharmacology; D002268:Carboxypeptidases / Q000494:pharmacology; D002918:Chymotrypsin / Q000494:pharmacology; D004950:Esterases / Q000494:pharmacology*; D006868:Hydrolysis; D007931:Leucyl Aminopeptidase / Q000494:pharmacology; D003012:Microbial Collagenase / Q000494:pharmacology; D011100:Polyglycolic Acid; D013268:Stimulation, Chemical; D013537:Sutures; D013718:Tensile Strength
D001672:Biocompatible Materials; D011100:Polyglycolic Acid; D001963:Bromelains; D004950:Esterases; D002268:Carboxypeptidases; D007931:Leucyl Aminopeptidase; D002918:Chymotrypsin; D003012:Microbial Collagenase