Hamster embryo cells transformed by herpes simplex virus: reactions with adeno-associated satellite virus (AAV) and its adenovirus helpers.
We have studied the reactions of hamster embryo cells transformed by ultraviolet-inactivated herpes simplex type 2 (333-8-9 T cells) to infections with adeno-associated satellite virus (AAV) and its adenovirus helpers. Resident HSV structural antigens were not detectable in early or late passage of 333-8-9 T cells. AAV structural antigens were not detected in these cells unless the cells were coinfected with a helper adenovirus. In early passage 333-8-9 T cells were permissive to infections with simian adenovirus SV15 whereas normal hamster cell line LSH was nonpermissive. In some late passages of 333-8-9 T cells infections with SV15 adenovirus led to the production of viruslike particles whose morphology was identical with reoviruses.
D000256:Adenoviridae; D000260:Adenoviruses, Human; D000261:Adenoviruses, Simian; D000818:Animals; D000956:Antigens, Viral; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D000229:Dependovirus / Q000276:immunology; D005814:Genes, Viral; D006378:Helper Viruses; D007181:Inclusion Bodies, Viral; D008854:Microscopy, Electron; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology
D000956:Antigens, Viral