Tumor antigen induction by the envelope-defective Bryan strain of Rous sarcoma viruses.
Chicken, quail, and turkey cells were infected and/or transformed by various avian leukosis or sarcoma oncovirus (ALSV) strains as well as by the envelope-defective Bryan high-titer strain of Rous sarcoma virus [BH-RSV(-)]. All fibroblast-transforming avian sarcoma viruses (ASV), including BH-RSV(-), were able to induce the expression of the previously described avian tumor-specific cell-surface antigen(s) (TSSA). Thus TSSA was group-specific for all tested transforming ASV. Since BH-RSV(-) is a stable deletion mutant lacking the capacity to code for the 85 000d major virus envelope glycoprotein (gp85), it seemed unlikely that the group-specific antigen determinants of gp85 that were recently detected on ALSV-infected cells could account for TSSA expression.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002642:Chick Embryo; D003673:Defective Viruses / Q000276:immunology*; D011784:Quail; D014422:Turkeys; D014764:Viral Proteins / Q000096:biosynthesis / Q000276:immunology
D000951:Antigens, Neoplasm; D014764:Viral Proteins