Investigation of the beta-adrenergic system in regulation of immunologic responses.
The influence of pharmacologic stimulation and blocking of the beta-adrenergic system on appearance of PF and RF cells, and intralymphocytic levels of cAMP were investigated. Stimulation of the beta-adrenergic receptor exerted an immunosuppressive effect, reflected by the numbers of PFC and RFC and raised levels of cAMP. Inhibition of the adrenergic beta-receptor stimulated immunologic responses and lowered levels of cAMP in lymphocytes. Confirmation of a specific adrenergic mechanism was provided by the absence of an effect of stimulation after prior blocking of the receptor. The possibility of a nonspecific membrane effect of beta-adrenergic drugs is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D011433:Propranolol / Q000494:pharmacology*; D012397:Rosette Formation
D011433:Propranolol; D000242:Cyclic AMP; D007545:Isoproterenol