[Effect of insulin, adrenaline and cyclic adenosine monophosphate on the activity of transport adenosine triphosphatases and pyruvate dehydrogenase of the rat myocardium under normal conditions and in insular insufficiency].
Experiments with rats were set up to study the interaction of hormones with Na+, K+-ATP-ase and Ca2+-ATP-ase of the sarcoplasmatic reticulum fragments and with pyruvate-dehydrogenase of the myocardial mitochondria in healthy rats and the ones with alloxan diabetes. Insulin was found to activate, while epinephrine and c-AMP to inhibit Na+, K+-ATP-ase. The Ca2+-ATP-ase is activated with epinephrine and c-AMP. In alloxan diabetes Na+, K+-ATP-ase is inhibited and Ca2+-ATP-ase and pyruvate-dehydrogenase--activated.
D000241:Adenosine; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000473:pathology; D004336:Drug Antagonism; D004837:Epinephrine / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology*; D009206:Myocardium / Q000166:cytology* / Q000473:pathology; D011188:Potassium / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D011773:Pyruvates; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D012964:Sodium / Q000378:metabolism
D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D012964:Sodium; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D000241:Adenosine; D011188:Potassium; D002118:Calcium; D004837:Epinephrine
Vliianie insulina, adrenalina i tsiklicheskogo adenozinmonofosfata na aktivnost' transportnykh ATF-az i piruvat-degidrogenazy miokarda krys v norme i pri insuliarnoĭ nedostatochnosti.