The signal from fruiting body and conus tips of Dictyostelium discoideum.
Tips from fruiting bodies and conuses were transplanted into interphase fields of Dictyostelium discoideum amoebae. Progressively increasing concentrations of beef-heart phosphodiesterase added to the fields significantly decreased the chemotactic range of the responding amoebae. The findings suggest that the tip secretes c-AMP. We also find that the chemotactic range is independent of the size of the tip implying that the tip may produce a regulating gradient.
D000818:Animals; D002465:Cell Movement; D002633:Chemotaxis / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000254:growth & development*; D009235:Myxomycetes / Q000254:growth & development*; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D013997:Time Factors; D014184:Transplantation, Homologous
D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases