Decreased spinal cord cGMP in murine (wobbler) spontaneous lower motor neuron degeneration.
Of the secondary messengers, cyclic quanosine monophosphate, but not cyclic adenosine monophosphate, was reduced by 80% in the cervical spinal cord and by 56% in the cerebellum of clinically affected homozygote "wobbler" mice compared to sex- and age-matched litter-mate clinically unaffected control mice. A neurotransmitter, gamma aminobutyric acid, and high-energy intermediates, adenosine triphosphate and phosphocreatine, were not significantly different in affected or unaffected mice.
D000818:Animals; D001923:Brain Chemistry; D000242:Cyclic AMP / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis*; D004195:Disease Models, Animal; D051379:Mice; D009046:Motor Neurons; D009154:Mutation; D009468:Neuromuscular Diseases / Q000378:metabolism*; D013116:Spinal Cord / Q000032:analysis*; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D005680:gamma-Aminobutyric Acid; D000242:Cyclic AMP; D006152:Cyclic GMP