[Effects of levodopa and piribedil on cyclic AMP levels in cerebrospinal fluid in rats (author's transl)].
30 min after injection of levodopa (200 mg/kg) into rats the cAMP levels in the cisternal fluid were significantly elevated by 60% over controls. When dopamine-beta-hydroxylase was inhibited by bis-(4-methyl-1-homopiperazinyl-thiocarbonyl)-disulfide (Fla 63) the levodopa induced increase of cAMP levels was less marked, it was suppressed by propranolol (10 mg/kg), a beta-adrenergic blocking agent. Piribedil (10 mg/kg) failed to influence cisternal cAMP concentrations. The findings do not support the concept of a dopamine-sensitive adenylate cyclase in vivo, and suggest a beta-adrenergic stimulation of cerebral adenylate cyclase by metabolites of levodopa.
D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D004298:Dopamine / Q000502:physiology; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D010879:Piperazines; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D007980:Levodopa; D011433:Propranolol; D010891:Piribedil; D000242:Cyclic AMP; D004298:Dopamine; D010646:Phentolamine
Zur dopaminempfindlichen Adenylzylase des Gehirns: Wirkung von L-DOPA und Piribedil auf die cAMP-Konzentration im Liquor cerebrospinalis