[Effect of cytostatic drugs, administered against the background of the action of insulin and thyroxine, on the processes of glycolysis and biosynthetic processes of neoplastic cells].
Experiments conducted on albino rats with a grafted tumour of transplantable alveolar mucinous carcinoma PC evidence that the cytostatic effect of thiophosphamide and sarcolysin equally grows in strenght with simultaneous introduction of thyroxin or insulin into the organism. In the same conditions the antineoplastic action of phthorafur is in a greater measure determined by the level of insulin and to a lesser degree by that of thyroxin. An analysis of the results subsequent to a biochemical examination (determination of the pyruvate, lactate, thiamine concentration in the blood and in the tumour, the rate of the 14C-glyxine incorporation in the protein of cancer cells) bears proof to the fact the neoplasm continues to definetly react in response to exogenously introduced hormones, this bringing changes into the kinetic and dynamic properties of the cytostatics.
D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004357:Drug Synergism; D006019:Glycolysis / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000096:biosynthesis; D008558:Melphalan / Q000627:therapeutic use; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D011773:Pyruvates / Q000096:biosynthesis; D051381:Rats; D005641:Tegafur / Q000627:therapeutic use; D013831:Thiamine / Q000096:biosynthesis; D013852:Thiotepa / Q000627:therapeutic use; D013974:Thyroxine / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007328:Insulin; D007773:Lactates; D009363:Neoplasm Proteins; D011773:Pyruvates; D005641:Tegafur; D013852:Thiotepa; D008558:Melphalan; D013974:Thyroxine; D013831:Thiamine
Vliianie tsitostaticheskikh sredstv, vvodimykh na fone deistviĭa insulina i tiroksina, na glikoliticheskie i biosinteticheskie protsessy opukholevykh kletok.