Scanning electron microscopic surface morphology of isolated hepatocytes from normal and premalignant rat liver.
Scanning electron microscopy was performed on hepatocytes isolated after collagenase perfusion of livers from rats fed 2-acetylaminofluorene (AAF) in the diet for 6--8 weeks and on hepatocytes from control rats. The premalignant AAF-cells showed a greater variation in cell size and shape. They also exhibited a reduced number of microvilli and more blebs and other protrusions on the surface than hepatocytes from control animals.
D015073:2-Acetylaminofluorene; D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure*; D008099:Liver / Q000166:cytology / Q000648:ultrastructure*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000648:ultrastructure; D008297:Male; D003012:Microbial Collagenase; D008855:Microscopy, Electron, Scanning; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000648:ultrastructure; D010477:Perfusion; D011230:Precancerous Conditions / Q000648:ultrastructure; D051381:Rats
D015073:2-Acetylaminofluorene; D003012:Microbial Collagenase