title: Acrodermatitis enteropathica. II. Zinc deficiency and ultrastructural findings.
abstract: The basic defect in acrodermatitis enteropathica (A.E.) is zinc deficiency caused by zinc malabsorption. The clinical symptoms disappear and serum zinc levels normalize after oral treatment with zinc. A report is given on two siblings suffering from A.E., both treated with oxyquinolines for a long period with changing clinical success. A permanent clinical remission could be achieved by treatment with zinc-sulphate at doses of 110-220 mg daily. The serum zinc levels normalized. The correlation between the zinc concentration of the hair and the kind of therapy was not very close. As we have shown in our first communication, the Paneth cells of the intestinal mucosa display ultrastructural changes in form of an unhomogeneous structure of the cytoplasm, formation of giant granules, and inclusion bodies. The zinc-therapy led to a complete normalization of the pathological changes in the Paneth cells. Thus, the changes in the Paneth cells in A.E. are the result and not the cause of zinc deficiency.
mesh_terms: D000169:Acrodermatitis / Q000188:drug therapy / Q000473:pathology*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002479:Inclusion Bodies; D007583:Jejunum / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D012075:Remission, Spontaneous; D015032:Zinc / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use
chemical_list: D015032:Zinc