Correlation of herpes simplex virus types 1 and 2 with clinical features of infection.
Strains (338) of herpes simplex virus (HSV) were isolated in Stockholm during 1965-1974. By immunoelectroosmophoresis it was possible to identify all strains as either HSV type 1 (HSV-1) or 2 (HSV-2). No strains of intermediate antigenic type or with untypable characteristics were found. The antigenic type of HSV was correlated with body site and clinical features of infection. A case of severe, recurrent, abdominal pain in association with HSV-2 infection is described. In one patient with acute aseptic meningitis, both coxsackievirus A9 and HSV-2 were isolated from the same specimen of cerebrospinal fluid. Serology suggested a primary infection with coxsackievirus A9 and a recurrent HSV-2 infection. HSV-1 was isolated from specimens of cerebrospinal fluid. Serology suggested a primary infection with coxsackievirus A9 and a recurrent HSV-2 infection. HSV-1 was isolated from specimens of cerebrospinal fluid from two of four adults with HSV encephalitis.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004660:Encephalitis / Q000382:microbiology; D004770:Enterovirus / Q000302:isolation & purification; D005260:Female; D006561:Herpes Simplex / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007122:Immunoelectrophoresis; D007223:Infant; D008297:Male; D008582:Meningitis, Aseptic / Q000382:microbiology; D008875:Middle Aged; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification; D013548:Sweden
D000956:Antigens, Viral