Monkeypox-specific antibodies in human and simian sera from the Ivory Coast and Nigeria.
A test for monkeypox-specific antibodies is described. Monkeypox immune sera can be made type-specific by immunoabsorption with heterotypic poxvirus extracts. Monkeypox-specific antibodies were demonstrated in sera from 9 cynomolgus monkeys (Macaca fascicularis) that had previously been experimentally infected with monkeypox. Monkeypox-specific antibodies were found in 3 wild-caught African monkeys (Cercopithecus spp.) and in 3 human sera collected from Africans in the Ivory Coast and Nigeria 3(1/2)-4 years after they had suffered a pox-like infection. Monkeypox had been recognized in one of the patients by virus isolation, and had been suspected in the others for epidemiological reasons. Vaccinia-specific antibodies were found in 4 human sera collected 6 weeks after smallpox vaccination.The serological results provide the first laboratory evidence of a monkeypox reservoir in wild monkeys.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D007560:Cote d'Ivoire; D000882:Haplorhini; D006801:Humans; D008251:Macaca; D008992:Monkey Diseases / Q000175:diagnosis; D008993:Monkeypox virus / Q000276:immunology*; D009549:Nigeria; D011212:Poxviridae / Q000276:immunology*; D011213:Poxviridae Infections / Q000175:diagnosis* / Q000662:veterinary
D000914:Antibodies, Viral