Endocrine influences on ulceration and regeneration in the alkali-burned cornea.
Subconjunctival dibutyryl 3',5' cyclic adenosine monophosphoric acid (DBcAMP) produced a statistically significant reduction of ulceration in the alkaliburned rabbit cornea. No effect on epithelial cell growth was observed. DBcAMP also caused a statistically significant acceleration of corneal neovascularization in the first two weeks postburn. Medroxyprogesterone acetate also affected the development  of corneal ulcers postalkali burn, but in a less well-defined manner. Dinoprost and indomethacin did not seem to influence this lesion. Cyclic adenosine monophosphoric acid may therefore possess a potential for use in the alkali-burned human eye.
D000468:Alkalies / Q000009:adverse effects; D000818:Animals; D003994:Bucladesine / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000188:drug therapy*; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000473:pathology / Q000517:prevention & control*; D007213:Indomethacin / Q000627:therapeutic use; D008525:Medroxyprogesterone / Q000627:therapeutic use; D011817:Rabbits; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D000468:Alkalies; D003994:Bucladesine; D008525:Medroxyprogesterone; D007213:Indomethacin