Effect of proteinase inhibitor in experimental tumors.
Aprotinin, a wide range proteinase inhibitor, was given alone to tumor-bearing mice and life span and several tumor growth parameters were recordered. Aprotinin showed anti-tumor effects in Hepatoma 22 and Lewis lung carcinoma, remaining ineffective in Sarcoma 37, Leukemia L1210 and Ehrlich ascitic carcinoma.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D007939:Leukemia L1210 / Q000188:drug therapy; D008113:Liver Neoplasms; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012509:Sarcoma / Q000188:drug therapy
D007611:Aprotinin