The influence of dibutyryl cGMP on the rabbit auricle.
Dibutyryl cGMP, like acetylcholine, shortens and reduces repolarization and overshoot of the action potential, slightly hyperpolarizes the cell and decreases the force of the contraction in the atrial working muscle. It suggests that cGMP may mediate the action of acetylcholine in the atrial working fibres.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D006152:Cyclic GMP / Q000031:analogs & derivatives*; D003864:Depression, Chemical; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology*; D006325:Heart Atria / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits
D003995:Dibutyryl Cyclic GMP; D006152:Cyclic GMP; D000109:Acetylcholine