[Effect of N-6 2'-O-dibutyryl adenosine 3'-5'monophosphate (dibutyryl cyclic AMP) on the condenstion of the X chromosome into the form of a Barr body].
Addition of exogen DB-c AMP in medium of human fibroblasts culture, with 46 XX karyotypes, enables us to observe a high frequency of Barr bodies, about 80 or 85%. This observation suggests that the condensation of the X chromosome in the form of Barr bodies depends on the level of endogen cyclic AMP.
D003994:Bucladesine / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D012728:Sex Chromatin / Q000187:drug effects*; D012730:Sex Chromosomes / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology
D003994:Bucladesine; D013806:Theophylline
L'action de N 6 2'-O-dibutyril adénosine 3.5-monophosphate cyclique (DB AMP c) sur la condensation du chromosome X sous forme de corpuscule de Barr