Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response.
Human polymorphonuclear leukocytes treated with cytochalasin B release the lysosomal enzyme beta glucuronidase during contact with serum-activated zymosan particles. Histamine increases intracellular cyclic adenosine monophosphate and inhibits release of this enzyme. The H2 antihistamine metiamide blocks the histamine inhibition of lysosomal enzyme release and the increase in the intracellular adenoisine 3,5'-monophosphate of granulocytes. Chlorpheniramine, an H1 antihistamine, did not block the histamine inhibition of granulocyte lysosomal enzyme release.
D000242:Cyclic AMP / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005966:Glucuronidase / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008247:Lysosomes / Q000201:enzymology; D008785:Metiamide / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*; D015054:Zymosan
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D008785:Metiamide; D006632:Histamine; D015054:Zymosan; D000242:Cyclic AMP; D005966:Glucuronidase