title: A mucosal disease virus as a cause of abortion, hairy birth coat and unthriftiness in sheep. 2. Observations on lambs surviving for longer than seven days.
abstract: A condition in Australian sheep resembling border disease was transmitted by the inoculation of pregnant ewes with material from affected lambs. This material contained mucosal disease virus (MDV). Twenty-two lambs comprising 6 from uninoculated control ewes, together with 11 with hairy coats and 5 with normal coats from inoculated ewes, were observed from 7 to 182 days after birth. Nine of the lambs from inoculated ewes died during the experiment from a variety of causes. Glial cell abnormalities were observed in control and affected lambs, but only 4 of the 11 hairy lambs were judged to have abnormal glial cells. There were no consistent histopathological findings indicative of MDV infection. MDV was recovered from tissues of all 11 hairy lambs, but not from any of the lambs with normal coats. The hairy lambs appeared to be immunologically tolerant to the virus. Susceptible sheep in contact with the hairy lambs were infected with MDV. It is suggested that a condition in Australian lambs characterised by hairiness of the birth coat and poor viability is due to foetal infection with a mucosal disease virus.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral; D001921:Brain / Q000473:pathology; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology / Q000302:isolation & purification; D009457:Neuroglia; D011234:Precipitins; D012328:RNA Viruses; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology; D014777:Virus Diseases / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D011234:Precipitins