[Effect of enteral administration of sodium ribonucleate on the synthesis of amino acyl t RNA in the liver and skeletal muscles of rabbits in experimental hypercorticism].
Daily, for 14 days, rabbits of one group were injected with corticotropin, i.e. ACTH-zinc-phosphate (10 units/kg), whereas rabbits of another group were given (in addition) sodium ribonucleate (40 mg/kg) through a tube into the stomach. Formation of lysyl-tRNA, leucyl-tRNA, and alanyl-tRNA in the liver and the skeletal muscles proved to be significantly greater in the animals which received ACTH together with sodium ribonucleate, as compared to that in the animals given the hormone alone. Hyperglycemia, hepatomegaly, and emaciation were less pronounced in the animals given both the preparations.
D000308:Adrenocortical Hyperfunction / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D007422:Intestines; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D012343:RNA, Transfer / Q000096:biosynthesis*; D011817:Rabbits; D012964:Sodium / Q000008:administration & dosage* / Q000494:pharmacology
D000324:Adrenocorticotropic Hormone; D012343:RNA, Transfer; D012964:Sodium
Vliianie enteral'nogo vvedeniia ribonukleata natriia na obrazovanie aminoatsil T-RNK v pecheni i skeletnykh myshtsakh krolikov pri eksperimental'nom giperkortitsizme.