[Mechanism of the inhibitory effect of BCG vaccine on specific antitumor immunity in Syrian hamsters].
The duration of inhibiting influence of BCG vaccine on specific antitumour immunity and possibility of SV40-induced resistance restoration in Syrian hamsters after the vaccination was studied. Antitumor immunity in animals immunized with SV40 virus and then inoculated with BCG was demonstrated to be abrogated one year after the vaccination. Reinoculation of the subjected to combined immunization animals with SV40 virus induced specific antitumour resistance in them again. The data presented may be interpreted as an argument favouring the cell-mediated nature of the phenomenon described.
D000818:Animals; D000956:Antigens, Viral / Q000008:administration & dosage*; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D006224:Cricetinae; D007114:Immunization; D007117:Immunization, Secondary; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D013539:Simian virus 40 / Q000276:immunology*
D000956:Antigens, Viral; D001500:BCG Vaccine
Izuchenie mekhanizma ingibiruiushchego vliianiia vaktsiny BTsZh na spetsificheskiĭ protivoopukholevyĭ immunitet u siriĭskikh khomiakov.