Virus antibody levels in IgA deficiency.
IgA-deficient blood donors and their age- and sex-matched controls were compared for the occurrence of complement-fixing antibodies in serum against several viruses. The level in the IgA-deficient persons was slightly higher against several respiratory pathogens (adenoviruses, type B influenza virus, parainfluenza virus, and respiratory syncytial virus) that give rise to localized infections, and against coxsackie B group of viruses. No corresponding difference was observed in mumps, varicella, and cytomegalovirus infections, where viraemia is a characteristic feature, or in Mycoplasma pneumoniae infection.
D000260:Adenoviruses, Human / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis; D001782:Blood Donors; D003587:Cytomegalovirus / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000276:immunology*; D004770:Enterovirus / Q000276:immunology; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D018108:Respirovirus / Q000276:immunology
D000914:Antibodies, Viral; D007070:Immunoglobulin A