[Effect of chlorimipramine on the so-called ponto-geniculo-occipitalactivity (PGO) in a primate, Papio hamadryas (author's transl)].
Three hamadryas adult baboons (female) received 24 daily injections of Chlorimipramine (1.7 mg/kg). The effects on sleep were nearly identical with the effects observed in man. PGO activity, recorded in the lateral geniculate nucleus, was much disturbed. The total number of PGO fell downward from the first recording. The number of PGO/min during paradoxial sleep was even more decreased. This fact suggests a selective influence of CL I on the mechanisms of PGO activity. Is the particular effect of importance to the treatment of depression symptoms?
D000818:Animals; D002997:Clomipramine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D004569:Electroencephalography; D005260:Female; D005829:Geniculate Bodies / Q000187:drug effects* / Q000502:physiology; D000882:Haplorhini; D009778:Occipital Lobe / Q000187:drug effects* / Q000502:physiology; D010215:Papio / Q000502:physiology*; D011149:Pons / Q000187:drug effects* / Q000502:physiology; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects
D003984:Dibenzazepines; D002997:Clomipramine
Effet de la chlorimipramine sur l'activité de pointes "ponto-géniculo-occipitales" (PGO) du babouin Papio hamadryas