Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008750:Methyldopa / Q000378:metabolism* / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011809:Quinones / Q000494:pharmacology; D051381:Rats; D013481:Superoxides / Q000378:metabolism
D002395:Catecholamines; D011506:Proteins; D011809:Quinones; D013481:Superoxides; D008750:Methyldopa; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; D010100:Oxygen