[Adrenal glucocorticoid function and cytoplasmic dehydrogenase activity in the presnece of mechanical and toxic liver damage].
Against the background of low steroid metabolism in the liver there was noted some decrease in the rate of corticosterone synthesis by the adrenal gland sections, and also, a decrease in the dehydrogenase activity in the cytoplasm of adrenal cells in male rats 48 hours after partial hepatectomy, as compared to the sham-operated animals. These changes resulted from suppression of the central mechanisms of stress realization due to the lowered steroid metabolism. Intraperitoneal administration of carbon tetrachloride (0.1 ml per 100 g of body weight) at the same periods led to a significant intensification of the steroidogenesis in the adrenal tissue and to the activation of NAD-dependent dehydrogenases in the cytoplasm. The role of toxic injury of the glands in the changes of the functional state of the adrenal cortex cells is discussed.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000311:Adrenal Glands / Q000201:enzymology / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D003345:Corticosterone / Q000096:biosynthesis; D006498:Hepatectomy; D066298:In Vitro Techniques; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats
D015062:11-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone; D010088:Oxidoreductases; D003345:Corticosterone
Gliukokortikoidnaia funktsiia i sktivnost' tsitoplazmaticheskikh degidrogenaz nadpochechnikov pri mekhanicheskom i toksicheskom povrezhdenii pecheni