title: Report of Joint Committee for Stroke Resources. IV. Brain edema in stroke.
abstract: A classification of brain edema is provided as well as an extensive review of the animal models from which we have derived most of the basic information we have about the formation and resolution of edema. The clinical aspects of cerebral edema in stroke are discussed and also modern methods for identifying cerebral edema in the human. Attention is given to computed tomography and enhanced CT and advances in their application to this condition. Treatment of cerebral edema in the stroke patient using glycerol, dextran 40, mannitol, steroids, and other drugs is discussed and the need pointed out for controlled clinical trials of the therapeutic effectiveness of these agents.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000628:Aminophylline / Q000627:therapeutic use; D000818:Animals; D001463:Barbiturates / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002543:Cerebral Hemorrhage / Q000150:complications; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000150:complications*; D003911:Dextrans / Q000627:therapeutic use; D004195:Disease Models, Animal; D004232:Diuretics / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005990:Glycerol / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D002542:Intracranial Embolism and Thrombosis / Q000150:complications; D002546:Ischemic Attack, Transient / Q000209:etiology; D008353:Mannitol / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors; D011877:Radionuclide Imaging; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D001463:Barbiturates; D003911:Dextrans; D004232:Diuretics; D004791:Enzyme Inhibitors; D010726:Phosphodiesterase Inhibitors; D000628:Aminophylline; D008353:Mannitol; D005990:Glycerol