Myocardial infarct imaging with technetium-labeled complexes.
Detection of acute myocardial infarction as an area of increased activity has intrigued investigators for some time. Initial attempts with 203Hg-chlormerodrin and 203Hg-fluorescein analogues were successful in man. More recently, however, successful imaging of the acute myocardial infarct has been achieved with several 99mTc complexes. A large group of radiotracers localize in acutely damaged tissue in various models of experimental infarction. From these data, a number of specific structural properties associated with infarct avidity have been identified; these include the presence of mercury and the structural configuration of the organic carrier.
D000818:Animals; D011756:Diphosphates; D004164:Diphosphonates; D004285:Dogs; D005452:Fluoresceins; D006801:Humans; D008631:Mercury Radioisotopes; D009203:Myocardial Infarction / Q000175:diagnosis*; D009941:Organomercury Compounds; D011877:Radionuclide Imaging; D051381:Rats; D013329:Structure-Activity Relationship; D013400:Sugar Acids; D013667:Technetium; D013752:Tetracycline
D011756:Diphosphates; D004164:Diphosphonates; D005452:Fluoresceins; D008631:Mercury Radioisotopes; D009941:Organomercury Compounds; D013400:Sugar Acids; D013667:Technetium; D013752:Tetracycline