title: Investigations into the mechanism of hormone release by rat adrenocortical cells.
abstract: Vinblastine treatment blocks corticosterone release from rat adrenal zona fasciculata without impairing hormone synthesis, and induces the formation of acid phosphatase-positive granular clumps at the juxta-sinusoidal pole of the cells. Autoradiography shows that ACTH administration to vinblastine-treated animals mobilizes the 3H-cholesterol stored in the lipid droplets and leads to a noticeable labelling of the granular clumps. The possible significance of these granules is discussed.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005089:Exocytosis; D008055:Lipids; D008297:Male; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D008055:Lipids; D014747:Vinblastine; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone