[Study of the effect of cAMP on the mitotic regimen in the esophageal epithelium of tumor-bearing mice].
The mitotic activity and number of DNA-synthesizing cells in the epithelium of the esophagus of the tumour-bearing albino mice were studied for 24 hours after the injection of dibutyryl cyclic 3', 5'-AMP. It was shown that injection of the preparation led to the blocking of cells in the G2-phase of the mitotic cycle, and to prolongation of mitosis during the first hours of the experiment without changing the total number of cells undergoing mitosis in the course of 24 hours.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000648:ultrastructure; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D004947:Esophagus / Q000166:cytology*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000648:ultrastructure*; D013997:Time Factors
D003994:Bucladesine; D004247:DNA; D000242:Cyclic AMP
Izuchenie vliianiia tsAMP na mitoticheskiĭ rezhim v épitelii pishchevoda mysheĭ-opukholenositeleĭ.