A convenient synthesis of 3-keto bile acids by selective oxidation of bile acids with silver carbonate-Celite.
A number of 3-keto bile acids were synthesized by the selective oxidation of bile acid methyl esters with silver carbonate-Celite in refluxing toluene. The pure 3-keto bile acids were isolated simply by filtering the reaction mixture and concentrating the filtrate. The relation of the bile acid structure to the oxidation rate is also discussed.
D001647:Bile Acids and Salts; D007202:Indicators and Reagents; D007664:Ketosteroids / Q000138:chemical synthesis*; D008722:Methods; D008968:Molecular Conformation; D012822:Silicon Dioxide; D018030:Silver Compounds
D001647:Bile Acids and Salts; D007202:Indicators and Reagents; D007664:Ketosteroids; D018030:Silver Compounds; C017450:keto bile acids; C017714:silver carbonate-Celite; D012822:Silicon Dioxide