[A study of toxic substances in pertussis cultures].
For the purpose of studying the toxic properties of pertussis strains with different agglutination composition and to ascertain the interrelationship between the action of the toxic substances and the serological type of the strains the author used a test of the weight change in albino mice to which crude and heated (at 56 degrees C for 10 minutes) suspensions of the strains of various serological types were injected intraperitoneally. The toxic properties were checked in 17 strains. The test of the change of the animal body weight with the determination of the regression coefficient permitted to determine roughly the presence of the toxic substances in the strains; the action of the thermostable dermonecrotic toxin and thermostable endotoxin was expressed with greater constancy than that of the lymphocytosis stimulating factor. There was no interrelationship between the manifestation of the action of toxic substances in the pertussis strains and their serological type. The toxic activity peristed in the strains stored in dried condition.
D000372:Agglutination Tests; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D001886:Bordetella pertussis / Q000276:immunology; D006358:Hot Temperature; D051379:Mice; D014118:Toxins, Biological / Q000032:analysis / Q000633:toxicity
D000942:Antigens, Bacterial; D014118:Toxins, Biological
Izuchenie toksicheskikh substantsii u kokliushnykh kul'tur