Lymphocyte subpopulations: analysis of T-cell rosette characters.
The data indicated that 2 populations of thymocytes existed: immature and mature types, identifiable by their rosette characters. The immature type was capable of changing spontaneously to the mature type, but was partially suppressed in vivo by the high concentration of thymic hormone present in the intrathymic environment. The mature types of thymocytes emigrated to the peripheral organ, accounting for their high percentage of small rosettes. Alternately, cells of peripheral organs might have originated from the immature type in the thymus. Once emigrated and exposed to a lower concentration of thymic hormone, they changed into the mature pattern. The fact that lymph node rosettes were less affected by culture in vitro indicated that once cells have changed to the mature pattern they have less ground for further differentiation.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D007158:Immunologic Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008198:Lymph Nodes / Q000276:immunology; D011458:Prostaglandins E / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology; D013947:Thymosin / Q000494:pharmacology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
D011458:Prostaglandins E; D013947:Thymosin; D003994:Bucladesine; D013806:Theophylline; D007545:Isoproterenol