Comparison of interferon action in interferon resistant and sensitive L1210 cells.
Translation inhibition, leu-tRNA aminoacylation and double-stranded RNA and ATP dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse L 1210 R and L 1210 S cells. No differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67K dalton phosphoprotein fraction in interferon-treated L 1210 S cell-free extracts. In non-responding cell-free lysates, the lack of stimulation of a 67K dalton phosphoprotein fraction cannot be explained by the presence of an increased level of some inhibitory activity, such as a phosphatase.
D000818:Animals; D002474:Cell-Free System; D007372:Interferons / Q000494:pharmacology*; D007930:Leucine; D007939:Leukemia L1210; D051379:Mice; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D014176:Protein Biosynthesis / Q000187:drug effects*; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism*; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development
D010750:Phosphoproteins; D012346:RNA, Transfer, Amino Acyl; D007372:Interferons; D007930:Leucine