Lack of effect of receptor blockers on the formation of long-lasting associations between sympathetic nerves and cardiac muscle cells in vitro.
Sympathetic nerves in vitro form long-lasting, intimate, functional relationships with cardiac muscle cells, but not with fibroblasts. In the presence of an adrenergic beta-blocker and a cholinergic muscarinic blocker, long-lasting relationships still take place. It was concluded that neurotransmitter "receptors" are not involved in the mechanism of "recognition" of cardiac muscle cells by sympathetic nerves.
D000818:Animals; D046508:Culture Techniques; D006321:Heart / Q000294:innervation; D009206:Myocardium / Q000166:cytology*; D009412:Nerve Fibers; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017981:Receptors, Neurotransmitter; D012601:Scopolamine / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D017981:Receptors, Neurotransmitter; D011433:Propranolol; D012601:Scopolamine