Slow persistent infection caused by visna virus: role of host restriction.
Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.
D000818:Animals; D002467:Cell Nucleus / Q000382:microbiology; D002831:Choroid Plexus / Q000382:microbiology; D046508:Culture Techniques; D004279:DNA, Viral / Q000032:analysis*; D012328:RNA Viruses / Q000254:growth & development*; D012756:Sheep; D014764:Viral Proteins / Q000032:analysis*; D014779:Virus Replication; D014790:Visna-maedi virus / Q000032:analysis / Q000254:growth & development*
D004279:DNA, Viral; D014764:Viral Proteins