Stimulation of calcium uptake into aortic microsomes by cyclic AMP and cyclic AMP-dependent protein kinase.
Enhancement of calcium uptake into rabbit aortic microsomes was seen at a cyclic AMP concentration of 10(-6) M in the presence of cyclic AMP-dependent protein kinase (ATP: protein phosphotransferase, EC 2.7.1.37). Protein kinase alone also increased calcium uptake, but cyclic AMP alone was without effect. The results suggest that stimulation of calcium sequestration may be the mechanism of cyclic AMP involvement in vascular smooth muscle relaxation.
D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology*; D066298:In Vitro Techniques; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D009130:Muscle, Smooth / Q000378:metabolism / Q000648:ultrastructure*; D009206:Myocardium / Q000648:ultrastructure; D011494:Protein Kinases / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical; D013997:Time Factors
D000242:Cyclic AMP; D011494:Protein Kinases; D002118:Calcium