Response of marmosets to experimental infection with Epstein-Barr virus.
The response of cotton-topped (CT) or white-lipped (WL) marmosets, inoculated with material containing Epstein-Barr virus (EBV), was studied. Twenty-five marmosets inoculated with 10(6)-10(8) cells from human or simian EBV-carrying lymphoblastoid cell cultures developed no detectable clinical disease. Transitory antibody titres to VCA were detected in sera from several of these marmosets. Thirty-eight marmosets inoculated with P3 virus (10(9) particles) and seven marmosets inoculated with 10(5) infectious units of HR-1 virus likewise developed no recognizable clinical or haematological disease over several years of observation. Fourteen marmosets were inoculated with 10(2)-10(4) transforming units (TFU) of EBV strain B95-8; five of 11 animals inoculated with 10(3)-10(4) TFU of virus developed malignant lymphoma and died 31-110 days PI. Antibodies to one or more EBV-specified antigens were detected in sera from nine of the inoculated marmosets. EBV-carrying lymphoblastoid cell cultures were established from the spleen and lymph-nodes of one animal that died with malignant lymphoma and from another animal that died 19 days PI from undetermined causes.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001402:B-Lymphocytes; D002051:Burkitt Lymphoma; D002143:Callitrichinae; D002460:Cell Line; D000882:Haplorhini; D004854:Herpesvirus 4, Human / Q000254:growth & development / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000276:immunology; D013154:Spleen / Q000166:cytology; D014776:Virus Cultivation
D000914:Antibodies, Viral