title: [Research on substances with antiviral activity. VII. Activity and lipophilic of property N-alkyl-2-chloro-3-formylindole thiosemicarbazone].
abstract: Thiosemicarbazones of N-alkyl-2-chloroindole-3-carboxaldehydes were synthesized and investigated for antiviral activity against RNA virus (parainfluenza type 3, HA-I/CR-8 stock) and DNA virus (vaccinia virus, HID stock). The effect of lipophilicity on the activity against vaccinia virus was considered. Relative lipophilicities were measured by a reversed phase thin-layer chromatographic technique. The most active compound N-isopropyl-2-chloroindole-3-carboxaldehyde thiosemicarbazone appeared comparable for its activity to methisazone.
mesh_terms: D000998:Antiviral Agents; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D007211:Indoles / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D013882:Thiosemicarbazones
vernacular_title: Ricerche su sostanze ad attività antivirale. Nota VII. Attività e lipofilia di tiosemicarbazoni di N-alchil-2-cloro-3-formilindoli.