Possible utilization of extracorporeal hemoperfusion in the treatment of coronary artery disease. A hypothesis and proposal for animal studies.
It is proposed that in vivo immunoadsorption may be utilized in the treatment of coronary artery disease. The proposed method is based on binding of low density lipoproteins and cholesterol to antibodies directed against low density lipoproteins which are bound to a matrix in an extracorporeal hemoperfusion column. The various observations that suggest the hypothesis are presented. The feasibility of the proposed method and some of the problems that may be encountered in its utilization are discussed. The method should be evaluated in animal studies prior to consideration of clinical trials in patients.
D000818:Animals; D003327:Coronary Disease / Q000097:blood / Q000276:immunology / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D007163:Immunosorbent Techniques; D008077:Lipoproteins, LDL / Q000097:blood
D008077:Lipoproteins, LDL