Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice.
Groups of C57BL/6J mice were administred cycloheximide (CYC) 30 min before or immediately after training on a passive avoidance task and tested 72 hr later. Some CYC-pretreated groups were given strychnine or d-amphetamine (d-amp) immediately after training and others were given d-amp 1 hr after training. Other groups were given diethyldithiocarbamate (DDC) at various times before or after training. Some DDC-pretreated groups were gived-amp or strychnine as described above for CYC groups. Immediate posttraining administration of 5 mg/kg d-amp, but not strychnine, prevented amnesia in CYC-pretreated mice. The DDC induced an apparent amnesia when administered from 30 min before training to 3 hr after training.  Posttraining administration of d-amp or strychnine did not prevent DDC-induced amnesia. These results are discussed in relation to previous suggestions that CYC- and DDC-induced amnesia may be the result of a functional impairment of catecholamine neurotransmitter systems by these drugs.
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D003513:Cycloheximide / Q000037:antagonists & inhibitors*; D003913:Dextroamphetamine / Q000627:therapeutic use*; D004050:Ditiocarb / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013331:Strychnine / Q000627:therapeutic use*; D013859:Thiocarbamates / Q000037:antagonists & inhibitors*
D013859:Thiocarbamates; D003513:Cycloheximide; D004050:Ditiocarb; D013331:Strychnine; D003913:Dextroamphetamine