Outgrowth and vegetative growth inhibition of Bacillus subtilis spores after transient exposure to polymyxin B.
Polymyxin B combined with the resting spores of Bacillus subtilis and inhibited outgrowth and vegetative growth after germination. The antibiotic was released from the resting spores and its inhibitory action was reversed by the addition of di- and trivalent metallic cations.
D001412:Bacillus subtilis / Q000187:drug effects / Q000502:physiology*; D002122:Calcium Chloride / Q000494:pharmacology; D002413:Cations, Divalent / Q000494:pharmacology; D005290:Ferric Compounds / Q000494:pharmacology; D011112:Polymyxin B / Q000378:metabolism / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D013171:Spores, Bacterial / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D002413:Cations, Divalent; D005290:Ferric Compounds; D011113:Polymyxins; D011112:Polymyxin B; D002122:Calcium Chloride