Xenotropic virus and autoimmunity in NZB mice.
The high-grade expression of xenotropic virus in NZB mice is determined by two autosomal dominant loci (Nzv-1 and Nzv-2). The progeny of crosses between NZB and the "nonautoimmune" virus-negative SWR strain segregate into three phenotypes: high-virus, low-virus, and virus-negative. The virologic phenotypes of the animals could be dissociated from the presence of either autoantibodies or immune complex-deposit nephritis and the latter could develop in the crosses without deposits of viral antigens in the glomeruli.
D000818:Animals; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D001327:Autoimmune Diseases / Q000235:genetics*; D003433:Crosses, Genetic; D051379:Mice / Q000235:genetics*; D008814:Mice, Inbred NZB; D009393:Nephritis / Q000276:immunology; D010641:Phenotype; D012328:RNA Viruses / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics*
D000936:Antigen-Antibody Complex; D000956:Antigens, Viral