title: Prognosis in primary amenorrhea.
abstract: A retrospective review of 62 patients with primary amenorrhea indicates that thoughtful clinical evaluation combined with dynamic hypothalamic-pituitary testing can usually determine the etiology and prognosis. A careful history, consideration of chronologic age/bone age/height relationships, and assay of serum gonadotropins distinguished all patients with medical diseases, ovarian failure, hypogonadotropic hypogonadism, and polycystic ovaries. Luteinizing hormone-releasing hormone (LH-RH) stimulation, sometimes combined with clomiphene therapy and estrogen provocation tests, assisted with prognostic and pathophysiologic evaluation, although patient management rarely changed. An age-inappropriate LH-RH test result was helpful in identifying patients with abnormal maturational patterns.
mesh_terms: D000293:Adolescent; D000328:Adult; D000365:Age Determination by Skeleton; D000568:Amenorrhea / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002648:Child; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D010901:Pituitary Function Tests; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone