Chemotactic antibody.
Antibody of the immunoglobulin G class to herpes simplex virus and antibody of the immunoglobulin M class to sheep red blood cells were coupled to the synthetic peptide formylmethionylleucylphenylalanine (fMet-Leu-Phe), which is chemotactic for both mononuclear and polymorphonuclear leukocytes. The resulting molecules were chemotactic and retained their antigen-binding activity. When antibodies coupled to fMet-Leu-Phe were incubated with antigen, the resulting immune complexes were also chemotactic. Chemotactic antibody may provide a potent means of enhancing the migration of inflammatory cells to specific sites.
D000906:Antibodies; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007249:Inflammation / Q000276:immunology; D009842:Oligopeptides / Q000494:pharmacology*; D018139:Simplexvirus / Q000276:immunology
D000906:Antibodies; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009842:Oligopeptides