title: Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology: evidence towards pre-pubertal vaccination of sero-negative female subjects.
abstract: Patients with abnormal cervical cytology demonstrated a higher prevalence of type-specific complement-fixing antibody to type 2 herpes simplex virus than patients with negative cervical cytology and patients with carcinoma of other body sites. Case-control differences were apparent irrespective of age, socio-economic class and marital status. By contrast, case groups demonstrated a lower prevalence of subjects with type 1 specific antibody. This raises the possibility that pre-adolescent exposure to type 1 herpes simplex virus may offer some measure of protection against pre-malignant and malignant cervical pathology.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis*; D000918:Antibody Specificity; D003168:Complement Fixation Tests; D005191:Family Characteristics; D005260:Female; D006801:Humans; D018139:Simplexvirus / Q000276:immunology*; D012959:Socioeconomic Factors; D002578:Uterine Cervical Dysplasia / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*; D014626:Vaginal Smears
chemical_list: D000914:Antibodies, Viral