Infantile neuroaxonal dystrophy. Schwann cell inclusion in the peripheral nerve.
Abnormal Schwann cell inclusion is reported in biopsied peripheral nerve in a case of infantile neuroaxonal dystrophy. In addition to non-specific dystrophic changes of the axons, the Schwann cells contained several distinct bodies which were composed of stacks of irregularly disposed membranes; in some instances, transformed Schwann cell cytoplasm was distined with similar bodies. This change has not been reported on this condition and its significance is briefly discussed.
D001706:Biopsy; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D010525:Peripheral Nerves / Q000648:ultrastructure*; D012583:Schwann Cells / Q000648:ultrastructure*; D013497:Sural Nerve / Q000473:pathology; D013577:Syndrome