Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor.
A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D009924:Organ Culture Techniques; D010010:Osteoclasts / Q000502:physiology / Q000648:ultrastructure; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors; D051381:Rats
D004791:Enzyme Inhibitors; D010281:Parathyroid Hormone; D003012:Microbial Collagenase; D002118:Calcium