[The effects of calcitonin, glucagon and the dibutyryl derivative of cyclic AMP on plasma-renin activity (author's transl)].
Infusion of 2 MRC/kg X h calcitonin in anaesthetised dogs produced a significant increase in plasma-renin activity, clearance of 51Dr-EDTA and 125I-o-iodohipuric acid, heart rate and urinary excretion of sodium, potassium, calcium and phosphates, while serum electrolytes and mean arterial pressure markedly fell. Infusion of 5 mug/kg X min glucagon produced a significant fall of plasma-renin, heart rate rose, but arterial mean pressure fell, and serum and urinary electrolytes did not change significantly, Cyclic AMP (dibutyryl-cAMP) significantly stimulated renin at a dose of 5 mg/min, while there were no significant changes in blood pressure, heart rate and serum and urinary electrolytes.
D000818:Animals; D001794:Blood Pressure; D003994:Bucladesine / Q000494:pharmacology*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D004285:Dogs; D005934:Glucagon / Q000494:pharmacology*; D006339:Heart Rate; D008297:Male; D009318:Natriuresis; D010758:Phosphorus / Q000652:urine; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood*
D010758:Phosphorus; D003994:Bucladesine; D002116:Calcitonin; D005934:Glucagon; D012083:Renin; D011188:Potassium; D002118:Calcium
Wirkung von Calcitonin, Glucagon und dem Dibutyrylderivat des zyklischen AMP auf die Plasma-Reninaktivität