[Effect of thyrotropin releasing hormone thyroxine on the activity of cytochrome oxidase in rat adenohypophysis].
Thyrotropin releasing-hormone (TRH) increased the activity of cytrochrome C oxidase in a concentration of 0.01 and 1.0 microgram/ml in the adenohypophysis of rats fed methylthiouracil for 6 weeks. This effect of TRH on the activity of the enzyme was blocked with T4 added to the incubation medium in a concentration of 20 microgram/ml. Actinomycin D (20 MICrogram/ml) prevented the block of the enzyme with thyroxin. In a concentration of 0.01 microgram/ml TRH, and in a concentration of 2.0 microgram/ml T4 failed to change the activity of cytochrome oxidase in the adenohypophysis of normal and partially thyroidectomized rats.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D004347:Drug Interactions; D003576:Electron Transport Complex IV / Q000378:metabolism*; D008779:Methylthiouracil / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology*
D003609:Dactinomycin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D003576:Electron Transport Complex IV; D013974:Thyroxine; D008779:Methylthiouracil
Vliianie tireotropin rilizing-gormona i tiroksina na aktivnost' tsitokhromoksidazy v adenogipofizakh krys.