[Modulator role of prostaglandins (Pg) in adrenergic neurotransmission in carotid sinus].
In Rabbit carotid sinus, the presence of sympathetic nerve endings capable of releasing noradrenaline has been demonstrated. The release of NA in response to sympathetic nerve stimulation was decreased by PgE2 and a precursor of Pg (arachidonic acid) but was strongly increased by an inhibitor of Pg biosynthesis (indomethacin). The experiments carried out demonstrated that freshly synthesized Pg acts in the same way as exogenous Pg and suggested that Pg could have a regulating effect on adrenergic neurotransmission in carotid sinus. The role of this regulating mechanism in the physiology of carotid sinus has been discussed.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D002346:Carotid Sinus / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects
D001095:Arachidonic Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D009638:Norepinephrine; D007213:Indomethacin
Rôle modulateur des prostaglandines (Pg) dans la neurotransmission adrénergique au niveau des sinus carotidiens.