title: Progressive necrotizing external otitis: treatment with ticarcillin and tobramycin.
abstract: The history of necrotizing external otitis, its diagnosis and management are reviewed. A case history is presented of a patient who was diagnosed as having progressive necrotizing external otitis with facial paralysis. In spite of standard medical treatment and aggressive surgical management, the disease process continued with progressive involvement of Cranial nerves IX and X. The Pseudomonas aeruginosa bacteria developed an increased minimal inhibitory concentration (MIC) to carbenicillin and gentamicin by requiring near toxic blood levels to be effective. Investigational ticarcillin (alpha-carboxy-3-thienylmethylpenicillin) and tobramycin were used successfully in resolving the infection.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002228:Carbenicillin / Q000627:therapeutic use; D003391:Cranial Nerves; D004359:Drug Therapy, Combination; D004431:Ear, External / Q000473:pathology; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010032:Otitis Externa / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D010406:Penicillins / Q000627:therapeutic use*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology; D011552:Pseudomonas Infections / Q000188:drug therapy*; D013982:Ticarcillin / Q000627:therapeutic use*; D014031:Tobramycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D013982:Ticarcillin; D002228:Carbenicillin; D014031:Tobramycin