Polydipsia, polyuria, and hypertension associated with renin-secreting Wilms tumor.
A 16-month-old black male infant had unusual thirst, polyuria, hyponatremia, and hypertension. His polyuria was unresponsive to vasopressin therapy, and his high blood pressure was not effectively controlled by antihypertensive drugs. Radiographic examinations revealed an occult Wilms tumor in the right kidney. After removal of the tumor, the signs and symptoms were relieved. The tumor had a renin activity about 280 times that of the adjacent renal cortex, and many intracytoplasmic secretory granules were found on electron microscopy. The pathogenesis of these clinical manifestations appears to be mediated through the physiologic pathways of renin-angiotensin II and renin-aldosterone.
D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology*; D007010:Hyponatremia / Q000209:etiology; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D011141:Polyuria / Q000209:etiology*; D012083:Renin / Q000378:metabolism*; D013894:Thirst; D009396:Wilms Tumor / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000601:surgery
D012083:Renin