Effects of L-tryptophan and ethanol on sleep parameters in the rat.
Sleep parameters were monitored following (1) a single 2 g/kg oral dose of ethanol, (2) an oral dose of L-tryptophan (600 mg/kg), and (3) administration of both drugs simultaneously. Ethanol reduced REM and increased slow wave significantly. The effects of L-tryptophan were apparent only in the case of one parameter, REM latency. Administration of both drugs resulted in a significantly shorter REM latency than that observed for ethanol alone. Results are discussed in terms of possible changes in the biosynthesis of 5-HT.
D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D010919:Placebos; D051381:Rats; D012701:Serotonin / Q000502:physiology; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology*
D010919:Placebos; D012701:Serotonin; D000431:Ethanol; D014364:Tryptophan