Effect of low density lipoprotein on proteoglycan synthesis by aorta cells in culture.
Increasing the content of human serum low density lipoprotein in the growth medium led to greater incorporation of 35S-sulfate into proteoglycan (mostly into dermatan sulfate) by primary aorta cells but did not affect similar incorporation by fibroblast cells. These results suggest a mechanism which can explain the increased deposition of lipid in aorta due to hyperlipidemia.
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D003470:Culture Media; D005347:Fibroblasts / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology* / Q000502:physiology; D011509:Proteoglycans / Q000096:biosynthesis*; D011817:Rabbits; D013431:Sulfates / Q000378:metabolism
D003470:Culture Media; D008077:Lipoproteins, LDL; D011509:Proteoglycans; D013431:Sulfates