[Sleep changes induced by chronic administration of S. 1694 (Survector) (author's transl)].
Five adult Macaca mulatta were studied during chronic administration (24 days) of S. 1694 (10 mg/kg, i.m.). This substance induced a significant increase of the first awakening (delaying sleep onset) and an enhancement of the duration of REM and stage 4 sleep. After withdrawal, the waking effect desappeared, but the increase in stage 4 sleep was maintained for one week and REM enhancement kept rising for 15 days. This observation of long-term action underlined the validity of drug experiments in chronic treatment: S. 1694 might set a new type of monoaminergic systems regulation.
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D000882:Haplorhini; D008253:Macaca mulatta; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D003986:Dibenzocycloheptenes
Etude chez le singe rhésus des modifications du sommeil induites par le S. 1694 en administration prolongée.