Investigations into the mechanism of hormone release by rat adrenocortical cells.
Vinblastine treatment blocks corticosterone release from rat adrenal zona fasciculata without impairing hormone synthesis, and induces the formation of acid phosphatase-positive granular clumps at the juxta-sinusoidal pole of the cells. Autoradiography shows that ACTH administration to vinblastine-treated animals mobilizes the 3H-cholesterol stored in the lipid droplets and leads to a noticeable labelling of the granular clumps. The possible significance of these granules is discussed.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005089:Exocytosis; D008055:Lipids; D008297:Male; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology
D008055:Lipids; D014747:Vinblastine; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone