Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses.
Replication of vaccinia and monkeypox viruses was impeded in the presence of 5-bromodeoxyuridine (BUdR) in RL-33 cells derived from rabbit lung tissue. The different degree of inhibition was found among strains of those viruses, in which it was evident that five strains (CV-1, Lister, IHD, Dairen-I and Ikeda) of vaccinia viruses resulted in more reduced yields of infectious virus than four strains (Sen-19, Orang Utan, Copenhagen and Sierra Leone) of monkeypox viruses. There was also strain variation in BUdR sensitivity within vaccinia viruses but not in the case of monkeypox viruses.
D001973:Bromodeoxyuridine / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D008993:Monkeypox virus / Q000187:drug effects*; D011212:Poxviridae / Q000187:drug effects*; D014616:Vaccinia virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D001973:Bromodeoxyuridine