Promotion of incidence of adenovirus type 12 transplantable tumors by carrageenan, a specific antimacrophage agent.
Carrageenan, a sulfated polygalactose with known macrophage-toxic properties, was used to ascertain the role of macrophages in resistance to adenovirus type 12 transplantable tumors. A single ip injection of 5 or 10 mg carrageenan led to increased incidence and more rapid growth of tumors in C3H mice. Carrageenan was most effective if given 1 day before tumor inoculation; the effectiveness decreased with increasing intervals before or after tumor cell injection. The macrophage stabilizer poly-2-vinylpyridine N-oxide injected sc (150 mg/kg) 1 day before carrageenan was given reduced the incidence of tumors. These data lend further support to the importance of macrophages in tumor immunity.
D000256:Adenoviridae; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D005260:Female; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000209:etiology*; D011144:Polyvinylpyridine N-Oxide / Q000494:pharmacology; D012822:Silicon Dioxide / Q000494:pharmacology
D012822:Silicon Dioxide; D002351:Carrageenan; D011144:Polyvinylpyridine N-Oxide