Infection of cultivated CNS tissue with herpes virus, HSVII. A reappraisal.
Organized cultures of newborn rat and hamster cerebellum were infected with herpes virus type II, after 7 and 14 days "in vitro". 48 h after the infection, electron microscopic examination of the cultures showed that astrocytes contained numerous intranuclear and intracytoplasmic viral particles, while neurons remained apparently intact. The specificity of the infection for a given cell type is discussed.
D000818:Animals; D001921:Brain; D002531:Cerebellum / Q000473:pathology; D006224:Cricetinae; D046508:Culture Techniques; D008854:Microscopy, Electron; D009457:Neuroglia; D009474:Neurons; D051381:Rats; D018139:Simplexvirus; D013997:Time Factors