Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis.
D000818:Animals; D001500:BCG Vaccine; D006528:Carcinoma, Hepatocellular / Q000276:immunology; D002464:Cell Migration Inhibition; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007111:Immunity, Cellular; D008113:Liver Neoplasms / Q000276:immunology; D008213:Lymphocyte Activation; D000432:Methanol; D009163:Mycobacterium bovis / Q000276:immunology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D013997:Time Factors; D014184:Transplantation, Homologous
D001500:BCG Vaccine; D000432:Methanol