title: Trisodium phosphonoformate, a new antiviral compound.
abstract: Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use / Q000633:toxicity; D002460:Cell Line; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D005561:Formates / Q000494:pharmacology / Q000633:toxicity; D006168:Guinea Pigs; D006566:Herpesviridae Infections / Q000188:drug therapy; D019384:Nucleic Acid Synthesis Inhibitors; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000633:toxicity; D010746:Phosphonoacetic Acid / Q000494:pharmacology; D018139:Simplexvirus / Q000201:enzymology
chemical_list: D000998:Antiviral Agents; D005561:Formates; D019384:Nucleic Acid Synthesis Inhibitors; D009943:Organophosphorus Compounds; D012321:DNA-Directed RNA Polymerases; D010746:Phosphonoacetic Acid