[Effect of nicotinamide, adenosine and nicotinamide-adenine dinucleotide on the NAD and NAD.H2 content in the liver and brain of intact rats and in hypoxia].
Nicotine-amide (25 mg/kg) in the liver and adenosine (50 mg/kg) in the liver and brain of intact rats enhance the NAD+NAD'H2 content. These drugs when used in the same doses raise the NAD+NAD'H2 level in the organs reduced in hypoxia and their proportion only with the combined application of these drugs. NAD (30 mg/kg) increases the NAD+NAD'H2 concentration in the liver and brain of intact and in the liver of "hypoxic" rats. It appears that in the mechanism of the antihypoxic action of nicotine-amide, adenozine and NAD a definite part plays their action on the level of nicotine-amide co-enzymes.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D000860:Hypoxia / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009243:NAD / Q000378:metabolism / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D004338:Drug Combinations; D009243:NAD; D009536:Niacinamide; D000241:Adenosine
Vliianie nikotinamida, adenozina i nikotinamidadenindinukleotida na soderzhanie NAD i NAD.H2  v pecheni i mozge intaktnykh krys i pri gipoksii.