Therapeutic effects of small-particle aerosols of ribavirin on parainfluenza (sendai) virus infections of mice.
Small-particle aerosol administration of ribavirin (1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) increased survival rates, extended the time to death, delayed lung pathology, and reduced pulmonary virus levels in Sendai virus-infected mice.
D000336:Aerosols; D000818:Animals; D051379:Mice; D008806:Mice, Inbred AKR; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*
D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin