[In vitro thyroid hormone reception by the adenohypophysis and hypothalamus of male rats of different ages].
In studying the thyroid hormone binding with the water-salt extracts of the adenohypophysis and the hypothalamus of male rats after Schreiber it was shown that with ageing there occurred in the adenohypophysis a redistribution of T4 and T3 binding in the direction fo an increase of the T4/T3 coefficient, and a reduction of the relative T3 binding, the latter bordering with the significant one. Some reduction of the T4/T3 coefficient, both in comparison with the rest of the tissues under study and in age aspect, was peculiar to the posterior hypothalamus. In the rats-tumour-carriers some changes in the thyroid hormone binding (reduction of the T4/T3 index in the posterior hypothalamus and its sufficiently high values in the adenohypophysis and the anterior hypothalamus) were similar to those observed in normal and ageing rats.
D000375:Aging; D000818:Animals; D002273:Carcinogens; D002279:Carcinoma 256, Walker / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000378:metabolism; D007034:Hypothalamus, Posterior / Q000378:metabolism; D066298:In Vitro Techniques; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism*
D002273:Carcinogens; D011956:Receptors, Cell Surface; D014284:Triiodothyronine; D013974:Thyroxine
Retseptsiia tireoidnykh gormonov in vitro adenogipofizom i gipotalamusom krys-samtsov razlichnogo vozrasta.