Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus.
Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes.
D000818:Animals; D005537:Aphthovirus / Q000254:growth & development / Q000472:pathogenicity*; D002417:Cattle; D046508:Culture Techniques; D005796:Genes; D051379:Mice; D009154:Mutation; D013696:Temperature; D014774:Virulence; D014779:Virus Replication