[Regulatory role of DOPA and components of the cyclic adenosine-3',5'-monophosphate system].
It was shown on albino mice that when DOPA-3H (20 muCi/mouse) was administered before nonradioactive DOPA (1 mg/mouse) tritium accumulation in the tissue of Harding-Passi's melanoma of these mice proved to increase. Melanoma radioactivity in this experimental group was double that in the tumour tissue of the animals to which DOPA-3H alone was administered. Examination of the adenylate cyclase, phosphodiesterase activity and of the level of cAMP in melanoma of mice 2 hours after DOPA administration (1 mg/mouse) showed accumulation of cAMP and an increase in the phosphodiesterase activity; as to adenylate cyclase activity--it fell. It is suggested that DOPA realizes its effect not only as melanin precursor, but also through the cAMP system, influencing the melanogenesis enzymes activity.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism / Q000494:pharmacology*; D008545:Melanoma / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism
D004295:Dihydroxyphenylalanine; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases
O reguliatornoĭ roli DOFA i komponentov sistemy tsiklicheskogo adenozin-3'-5'-monofosfata.