Effect of serum on the antiviral and anticellular activities of mouse interferon.
Fetal bovine serum markedly decreased the ability of mouse L-929 interferon preparations to inhibit the formation of L-929 clones, but did not affect their ability to inhibit vesicular stomatitis virus (VSV) plaque formation in these cells. This dissociation of effects by interferon preparations indicates that: 1. the mechanism of action of interferon for its anticlonal antiviral activities is different; or 2. the molecule responsible for the anticlonal activity is a separate growth inhibitory factor.
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects*; D005312:Fetal Blood; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects*; D051379:Mice; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects*
D007372:Interferons