Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities.
Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1--0.5 mM, but inhibited by higher concentrations.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D002229:Carbenoxolone / Q000494:pharmacology*; D007679:Kidney Medulla / Q000201:enzymology; D010726:Phosphodiesterase Inhibitors; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D014315:Triterpenes / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D014315:Triterpenes; D011451:Prostaglandin-Endoperoxide Synthases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D002229:Carbenoxolone