A synergistic interaction between the teratogenic effect of trypan blue and dietary deficiency in the rat.
There was an increased incidence, compared to controls, of exencephaly and microphthalmia in the offspring of rats fed a vitamin D deficient diet and injected with trypan blue on day 9 of gestation. Oral vitamin D did not reverse the effect.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002762:Cholecalciferol / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D014343:Trypan Blue / Q000633:toxicity*; D014808:Vitamin D Deficiency
D013723:Teratogens; D002762:Cholecalciferol; D014343:Trypan Blue