[Changes of the renin-angiotensin-aldosterone system under contraceptive steroids. Contribution to the etiology of hypertension under hormonal contraceptives].
Treatment with hormonal contraceptives leads to a considerable stimulation of the renin-angiotensin-aldosterone-system. First of all, there is a 2,5- to 4fold increase of renin substrate synthesis in the liver. As a consequence, more angiotensin I and angiotensin II are released. Angiotensin II stimulates the secretion of aldosterone in the adrenals, thus producing a higher aldosterone concentration in plasma. The urinary excretion of aldosterone is elevated to a lesser degree, probably because of the simultaneously increased binding of aldosterone to plasma proteins. The release of renin is suppressed to 50% by negative feedback mechanisms. Some possible factors in the etiology of hypertension induced by oral contraceptives are discussed.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D010450:Endopeptidases / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008099:Liver / Q000378:metabolism; D011485:Protein Binding; D012083:Renin / Q000097:blood*
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D000804:Angiotensin II; D000450:Aldosterone; D010450:Endopeptidases; D012083:Renin
Veränderungen des Renin-Angiotensin-Aldosteron-Systems unter kontrazeptiven Steroiden. Beitrag zur Atiologie der Hypertonie unter hormonalen Kontrazeptiva