Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria.
beta-Lapachone markedly increased the generation of superoxide anions and hydrogen peroxide by subcellular membranes of Bacillus subtilis and Bacillus stearothermophilus. Peroxide generation by beta-lapachone was parallel to the inhibition of growth in both microorganisms.
D000903:Antibiotics, Antineoplastic / Q000378:metabolism* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D001411:Geobacillus stearothermophilus / Q000187:drug effects / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009285:Naphthoquinones / Q000378:metabolism* / Q000494:pharmacology; D010100:Oxygen / Q000096:biosynthesis*; D013481:Superoxides / Q000096:biosynthesis*
D000903:Antibiotics, Antineoplastic; D009285:Naphthoquinones; D013481:Superoxides; C014638:beta-lapachone; D006861:Hydrogen Peroxide; D010100:Oxygen