title: Increased histamine sensitivity in mice after administration of endotoxins.
abstract: CFW mice given submicrogram doses of endotoxins intravenously became highly susceptible to the lethal effects of 0.5 mg of histamine given intraperitoneally 1 to 2 h later. The histamine-sensitizing effects of the endotoxins were transitory and disappeared within 6 to 8 h. L-Epinephrine administered intravenously immediately after histamine challenge protected mice from death, but aterenol and isoproterenol were ineffective. The histamine-sensitizing effect in endotoxins was precipitated by anti-endotoxin sera with a concomitant eightfold loss in activity. However, dissociation of the immune complex in 0.25 M acetic acid fully restored histamine-sensitizing activity. The transitory nature of the hypersensitivity produced by endotoxin and the high heat resistance of the active material prove that it is different from the histamine-sensitizing effects of pertussigen.
mesh_terms: D000375:Aging; D000818:Animals; D000936:Antigen-Antibody Complex; D001886:Bordetella pertussis; D002395:Catecholamines / Q000627:therapeutic use; D004306:Dose-Response Relationship, Immunologic; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000517:prevention & control; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D012477:Salmonella enteritidis; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000936:Antigen-Antibody Complex; D002395:Catecholamines; D004731:Endotoxins; D012701:Serotonin; D006632:Histamine