[Ectopic production of chorionic gonadotropin in apudomas (author's transl)].
Two pheochromocytomas, two carcinoid tumours of the ileum and one pancreatic vipoma showed APUD-system properties and formed electron-dense secretory granules indicating synthesis and storage of proteohormones. Besides catecholamines, 5-hydroxytryptamine and vasoactive intestinal polypeptide, all five tumours contained immunoreactive chorionic gonadotropin and also its free, protomeric beta chain as a sign of de-differentiation. Plasma of the tumour patients also contained immunoreactive chorionic gonadotropin and the free protomeric beta chain, both of which are useful tumour markers.
D058186:Acute Kidney Injury; D007516:Adenoma, Islet Cell / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001079:Apudoma / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D003681:Dehydration; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D010673:Pheochromocytoma / Q000378:metabolism; D011247:Pregnancy; D013577:Syndrome
D006063:Chorionic Gonadotropin
Ektopische Choriongonadotropinbildung in Apudomen.