Heterotransplantation of experimentally induced dog stomach adenocarcinoma to nude mice.
Heterotransplantation of gastric adenocarcinoma, induced in dog by N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) has been attempted to nude mouse. Biopsied materials from Borrmann 3 type carcinoma, which showed signet-ring cell carcinoma at the subcardiac region of a beagle dog, were inoculated into the muscles of the hind legs of BALB/c-nu/nu nude mice. Serial transmission was obtained in 2 lives, so far 4-5 passages. The histological findings of the grafts were mainly poorly differentiated adenocarcinomas.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D004285:Dogs; D005260:Female; D006614:Hindlimb; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009604:Nitrosoguanidines; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology*; D014183:Transplantation, Heterologous
D009604:Nitrosoguanidines