[Study of the metabolic synapse. II. Comparison of the effects of cyclic 3',5'-AMP and 3',5'-GMP].
Intracellular microiontoforetic injections of cyclic 3',5'-AMP and cyclic 3',5'-GMP elicit different responses in the same neuron. Drugs were injected by current of 1--10 nA using 3-barrel micropipettes. Unlike cyclic 3',5'-AMP arising the depolarization of the neuron, cyclic 3',5'-GMP usually hyperpolarizes it. An inhibitor of phosphodiesterases, papaverine, increases and prolongates effects of cyclic 3',5'-AMP and cyclic 3',5'-GMP, but in latter case the action of this drug seems to be less.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004357:Drug Synergism; D004553:Electric Conductivity; D006372:Helix, Snails; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D010208:Papaverine / Q000494:pharmacology
D010208:Papaverine; D000242:Cyclic AMP; D006152:Cyclic GMP
Izuchenie metabolicheskogo sinapsa. II. Sravnenie effektov tsiklicheskikh 3',5-AMP i 3',5-GMP