Cyclic AMP and cyclic GMP levels in glandular stomach of restrained rats.
Cyclic AMP and cyclic GMP were measured in glandular stomach of rats subjected to saline administration, cold (4 degrees C), restraint and restraint+cold after 15, 30, 60, 90 and 120 minutes. All animals subjected to restraint+cold had gastric ulceration after 2 hours. A significant but transient decrease in cAMP was observed 15 minutes after restraint+cold. A marked, sustained and significant decrease of cGMP was observed in the same group of animals. It is concluded that it seems unlikely to be a correlation between cAMP and cGMP changes of the stomach and the restraint-induced gastric ulceration.
D000818:Animals; D003080:Cold Temperature; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors
D000242:Cyclic AMP; D006152:Cyclic GMP