title: Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes.
abstract: Activation of adenylate cyclase in isolated rat liver plasma membranes by cholera toxin was demonstrated. The activation requires the presence of NAD+ and ATP and is irreversible.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002462:Cell Membrane / Q000201:enzymology; D004789:Enzyme Activation; D008099:Liver / Q000201:enzymology; D009243:NAD / Q000378:metabolism*; D051381:Rats; D014734:Vibrio cholerae
chemical_list: D001427:Bacterial Toxins; D009243:NAD; D000255:Adenosine Triphosphate; D000262:Adenylyl Cyclases