title: Increased de novo pyrimidine nucleotide synthesis in liver induced by ammonium ions in amounts surpassing the urea cycle capacity.
mesh_terms: D000818:Animals; D001380:Azauridine / Q000494:pharmacology; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000378:metabolism; D006528:Carcinoma, Hepatocellular; D003597:Cytosine Nucleotides / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008113:Liver Neoplasms; D008930:Mitochondria, Liver / Q000201:enzymology; D008954:Models, Biological; D009952:Ornithine / Q000494:pharmacology; D009963:Orotic Acid / Q000096:biosynthesis; D011742:Pyrimidine Nucleotides / Q000096:biosynthesis*; D000644:Quaternary Ammonium Compounds / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D014500:Uracil Nucleotides / Q000096:biosynthesis; D014508:Urea / Q000378:metabolism; D014532:Uridine Diphosphate Glucose / Q000096:biosynthesis
chemical_list: D003597:Cytosine Nucleotides; D011742:Pyrimidine Nucleotides; D000644:Quaternary Ammonium Compounds; D014500:Uracil Nucleotides; D009963:Orotic Acid; D001380:Azauridine; D014508:Urea; D009952:Ornithine; D002222:Carbamoyl-Phosphate Synthase (Ammonia); D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); D014532:Uridine Diphosphate Glucose