Properties of an Escherichia coli cytotoxin.
Isoelectric focusing of a heat-labile cytotoxin of Escherichia coli H30 revealed the presence of two molecular variants, pI 7.2 and a comparatively small quantity of pI 6.8. Predominant component pI 7.2 had a molecular weight of 28,000, induced some fluid accumulation in rabbit ileal loops, and showed no morphological response in Y-1 cells but a strong cytotoxic effect on Vero cells.
D000818:Animals; D000992:Antitoxins; D001427:Bacterial Toxins / Q000032:analysis / Q000494:pharmacology; D001681:Biological Assay; D000242:Cyclic AMP / Q000378:metabolism; D003603:Cytotoxins / Q000032:analysis / Q000494:pharmacology; D004926:Escherichia coli / Q000032:analysis; D066298:In Vitro Techniques; D007526:Isoelectric Point; D011817:Rabbits; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000992:Antitoxins; D001427:Bacterial Toxins; D003603:Cytotoxins; D000242:Cyclic AMP