[HLA system and rhizomelic pseudopolyarthritis].
26 HLA antigens of the loci A and B were studied in 50 patients with pseudo-polyarthritis and in 300 control subjects without any joint disease. The arthritis was isolated and not associated with temporal arteritis. An increase in frequency of both HLA antigens was noted in the patients studied: HLA-B5 = 24% as against 13% in controls (P = 0.05 and Pc NS). HLA-Bw38 = 18% as against 5.33% in controls (p = 0.002 - Pc = o.05). The rise in frequency of HLA-B5 and HLA-Bw38 was also found in 19 subjects with polyarthritis and temporal arteritis but not in 31 patients with temporal arteritis alone. In this disease, a link with the HLA-B14 antigen was noted in 50 cases (22.9% as against 8.6% in control). These results suggest that arthritis and temporal arteritis although sometimes associated are probably distinct diseases.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D003937:Diagnosis, Differential; D013700:Giant Cell Arteritis / Q000150:complications / Q000235:genetics; D006680:HLA Antigens / Q000032:analysis; D006621:Hip Joint; D006801:Humans; D008875:Middle Aged; D012785:Shoulder Joint; D013577:Syndrome
D006680:HLA Antigens
Systme HLA et pseudo-polyarthrite rhizomélique.