Glomerulosclerosis following irradiation and cytotoxic therapy for nephroblastoma.
A 6-year-old child had a nephrectomy for nephroblastoma followed by radiotherapy and chemotherapy with actinomycin D and vincristine. He died of metastatic disease 13 months after the operation. Autopsy showed a diffuse glomerulosclerosis in the remaining kidney which is attributed to the postoperative therapy.
D002648:Child; D003609:Dactinomycin / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011878:Radiotherapy / Q000009:adverse effects*; D014750:Vincristine / Q000009:adverse effects*; D009396:Wilms Tumor / Q000628:therapy
D003609:Dactinomycin; D014750:Vincristine