Radioactive nucleic acids-precursors: their potential value as tumor-localizing agents.
The distribution of 125I-uracil and 125I-deoxyuridine in tumor-bearing animals has been studied. 125I-deoxyuridine shows the characteristics of a tumor-scanning agent. The metabolic incorporation by tumors of this DNA-precursor indicates a potential value of this radiocompound for their detection, differentiation and follow-up of their evolution after therapy.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D004247:DNA; D003857:Deoxyuridine; D007457:Iodine Radioisotopes; D007945:Leukemia, Lymphoid / Q000175:diagnosis; D008113:Liver Neoplasms; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis*; D009374:Neoplasms, Experimental / Q000175:diagnosis; D009694:Nucleic Acid Precursors; D012313:RNA; D011877:Radionuclide Imaging; D051381:Rats; D014498:Uracil
D007457:Iodine Radioisotopes; D009694:Nucleic Acid Precursors; D014498:Uracil; D012313:RNA; D004247:DNA; D003857:Deoxyuridine