Peripheral nervous system affection in experimental lipidosis induced by 4,4'-diethylaminoethoxyhexesterol.
A picture of generalized phosphoglyceride and cholesterol storage was induced, in keeping with literary data, by the experimental administration of 4,4'-diethylaminoethoxyhexesterol to rats. An asset of this model lies in the discovery that considerable storage occurs in the peripheral nervous system in contrast to the CNS, whose resistance to hexesterol is generally known. The significance of this finding is briefly discussed.
D000818:Animals; D005260:Female; D006589:Hexestrol / Q000031:analogs & derivatives; D008064:Lipidoses / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D009197:Myenteric Plexus / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D051381:Rats
D006589:Hexestrol