The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes. I. Proliferative response.
The lymphocytosis-promoting factor of Bordetella pertussis is a potent mitogen for murine lymphocytes in vitro. The stimulatory response was not the result of specific antigen stimulation. Spleen and lymph node cells were responsive, whereas normal thymocytes were unresponsive. However, DNA replication was induced in cortisone-resistant thymocytes by lymphocytosis-promoting factor (LPF). Bone marrow cells were not stimulated by LPF.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001426:Bacterial Proteins / Q000276:immunology / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D001886:Bordetella pertussis / Q000276:immunology*; D002999:Clone Cells; D003208:Concanavalin A / Q000494:pharmacology; D003348:Cortisone / Q000494:pharmacology; D005260:Female; D007700:Kinetics; D037102:Lectins / Q000494:pharmacology; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D008218:Lymphocytosis / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D001426:Bacterial Proteins; D037102:Lectins; D003208:Concanavalin A; D003348:Cortisone