Histopathology of carcinomas of the liver in mice ingesting heptachlor or heptachlor epoxide.
C3H male and female mice, ingesting 10 ppm of the pesticides heptachlor or heptachlor epoxide in the diet, developed highly significant incidences of carcinomas of the liver. The carcinomas varied from well-differentiated to poorly differentiated and undifferentiated and were capable of invasion and metastasis.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D006338:Heart Neoplasms / Q000473:pathology; D006533:Heptachlor / Q000031:analogs & derivatives; D006534:Heptachlor Epoxide; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis; D012737:Sex Factors
D006534:Heptachlor Epoxide; D006533:Heptachlor