Enhanced affinity of opiate receptors for naloxone in striatal slices of morphine-dependent mice.
Slices of corpus striatum were allowed to accumulate 3H-morphine and then they were placed in a small chamber and superfused with Krebs-Ringer bicarbonate solution. 100 to 1 pM of naloxone caused an immediate increase in the release of morphine from the slices when it was placed in the superfusion fluid at 0, 5 or 15 min after the the start of the superfusion. Slices from morphine-dependent mice were more sensitive to the naloxone-induced release of morphine than those of control mice. The data suggest that the affinity of the opiate receptors in the corpus straitum for naloxone is increased in morphine-dependent mice.
D000818:Animals; D001667:Binding, Competitive; D003342:Corpus Striatum / Q000378:metabolism*; D004361:Drug Tolerance; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009020:Morphine / Q000378:metabolism; D009021:Morphine Dependence / Q000378:metabolism*; D009270:Naloxone / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013997:Time Factors
D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine