Further unravelling of the causes of ACTH-induced hypertension in the sheep.
1. Acute severe sodium subtraction (20-25% of total exchangeable sodium) before or during treatment with adrenocorticotrophic hormone (ACTH) does little to modify the increase in blood pressure induced by ACTH. 2. Chronic low salt diet, less than 5 mmol/day, abolishes the blood pressure increase, but the response can be restored by increasing the sodium intake to as little as 10 mmol/day. 3. 17alpha,20alpha-Dihydroxyprogesterone infused concurrently with other adrenal steroids will mimic ACTH hypertension and perhaps represents a new class of steroid capable of influencing blood pressure.
D000324:Adrenocorticotropic Hormone / Q000633:toxicity*; D000523:Algestone / Q000494:pharmacology; D000818:Animals; D006908:Hydroxyprogesterones / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced*; D012756:Sheep; D012964:Sodium / Q000172:deficiency / Q000378:metabolism
D006908:Hydroxyprogesterones; D000523:Algestone; D000324:Adrenocorticotropic Hormone; D012964:Sodium