[Effect of adrenocorticotropic hormone on nucleic acid and protein synthesis and content in the brain of rat embryos in the early stages of neurogenesis].
The injection of adrenocorticotropic hormone (ACTH) of prolonged effect at the doses of 4 and 10 M. U. to the intact rats from the 11th till the 15th day of pregnancy resulted in the twofold increase of protein content in the brain and its decrease in the liver of 15 days old embryos, as compared with the control ones. The content of DNA, RNA and proteins in the placenta of experimental animals increased as well. The rate of incorporation of 3H-thymidine in the liver DNA and 14C-leucine in the liver and brain acid-soluble protein decreased within small intervals of time following the treatment. The total radioactivity of proteins in the liver, brain and placenta calculated per DNA unit was similar to the control one whereas the specific radioactivity of total protein in the liver of experimental embryos was higher than in the control.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009420:Nervous System / Q000196:embryology*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D009419:Nerve Tissue Proteins; D012313:RNA; D000324:Adrenocorticotropic Hormone; D004247:DNA; D013936:Thymidine
Vliianie adrenokortikotropnogo gormona na sintez i soderzhanie nukleinovykh kislot i belka v golovnom mozge zarodysheĭ krys na rannikh stadiiakh neĭrogeneza.