Correlation of induced drug metabolism with titer of duck hepatitis virus in chickens.
While chickens infected with duck hepatitis virus showed no signs of clinical illness, their levels of hepatic cytochrome P-450 in response to phenobarbital induction and their microsomal aryl hydrocarbon hydroxylase activities in response to 3-methylcholanthrene induction were each found to correlate with the titer of virus recovered from the livers. These clear correlations indicate that avian hepatic drug metabolism is significantly modified during viral infection.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D002645:Chickens; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004770:Enterovirus / Q000472:pathogenicity; D004769:Enterovirus Infections / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D004371:Hepatitis Virus, Duck / Q000472:pathogenicity; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*
D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D010634:Phenobarbital