1-Alpha-hydroxycholecalciferol in the treatment of hypocalcaemic psychosis.
Two patients with profound hypocalcaemia due to uraemia and hypoparathyroidism respectively presented with alterations of mental state as their dominant symptom. 1-Alpha-hydroxycholecalciferol (1-alpha-OHD3) was chosen as the principal therapy because of its potency and rapid action. In both patients the plasma calcium was restored towards normal and the symptoms relieved within a very short period. The cases illustrate the role of 1-alpha-OHD3 in severe hypocalcaemia due to two different causes and provide experience on which to base treatment regimes for future patients similarly afflicted.
D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D002762:Cholecalciferol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D006996:Hypocalcemia / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D007011:Hypoparathyroidism / Q000150:complications; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology; D014511:Uremia / Q000150:complications
D006887:Hydroxycholecalciferols; D002762:Cholecalciferol; D002118:Calcium