Natural infection with influenza A (H3N2). The development, persistance and effect of antibodies to the surface antigens.
A technique for estimating antibodies to the neuraminidase antigens of influenza A is described. The antibody response to the haemagglutinin and neuraminidase antigens of influenza A (H3N2) was studied in a boys' public school over the four-year period 1970--4. During this time there were two outbreaks of influenza A and the effect of antibody on the result of natural challenge was investigated. No boy who had homotypic neuraminidase antibody had clinical influenza.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral; D002462:Cell Membrane / Q000276:immunology*; D002648:Child; D004196:Disease Outbreaks; D004739:England; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000201:enzymology / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage; D008297:Male; D009439:Neuraminidase / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; D009439:Neuraminidase