[The nephrotoxicity of the methicillin-gentamycin combination. Apropos of 5 cases].
Interstitial nephritis with acute renal failure was observed in 5 cases out of 6 treated by the association of methicillin and gentamycin, wheras no case, was observed when each of these antibodies was used separately. The mechanisms which might explain the potentialisation of these two drugs are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000139:chemically induced; D005334:Fever / Q000139:chemically induced; D005839:Gentamicins / Q000009:adverse effects*; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D008297:Male; D008712:Methicillin / Q000009:adverse effects*; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced
D005839:Gentamicins; D008712:Methicillin
La néphrotoxicité de l'association méthicilline-gentamycine. A propos de 5 observations