title: [Antiviral activity of experimental combination of 5-iodo-2-deoxyuridine with 6-azauridine and its effectiveness in the treatment of herpetic infection with lesions of the skin and mucous membranes].
abstract: The use of the combination of 5-iodo-2-dioxyuridine (IUDR) and 6-azauridine drugs differing in their mechanisms of action in an experimental herpetic infection demonstrated its definite antiviral activity, not only not inferior to the effect of each of the drugs alone, but also remaining sufficiently high when the concentration of IUDR was decreased 2-fold. In clinical trials in relapsing genital herpes all the drugs under study showed statistically significant therapeutic activity. The combined use of the drugs exerted a certain synergistic effect.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001380:Azauridine / Q000008:administration & dosage* / Q000494:pharmacology; D002478:Cells, Cultured; D004338:Drug Combinations; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008875:Middle Aged; D018139:Simplexvirus / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D001380:Azauridine; D007065:Idoxuridine
vernacular_title: Protivovirusnaia aktivnost' kombinatsii 5-ĭod-2-dezoksiuridina v éksperimente i ee éffektivnost' pri lechenii gerpeticheskoĭ infektsii s porazheniem kozhi i slizistykh obolochek.