[The neuropathies of monoclonal gammapathies. Immunofluorescence and immunolabelling in the electron microscopy of immunoglobulins with amyloid structure (author's transl)].
Five cases of peripheral neuropathies occurring with monoclonal gammapathies are studied by means of nerve biopsies. Immunofluorescence and HRP-immunolabelling with the electron microscope are performed. The direct pathogenic role of a subperineurial immunoglobulin deposit is pointed out. The relationship of the heavy chain monoclonal immunoglobulin with amyloid fibrils is discussed.
D000368:Aged; D000682:Amyloid / Q000032:analysis; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010525:Peripheral Nerves / Q000473:pathology / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000473:pathology*
D000682:Amyloid; D007136:Immunoglobulins
Les neuropathies des gammapathies monoclonales. Immunofluorescence et immunomarquage en microscopie electronique d'immunoglobulines à structure amyloïde.