Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.
Resistance to radiation leukemia virus-induced leukemogenesis is associated with the H-2D region of the H-2 complex, or with closely linked loci. The H-2Dd allele confers resistance ot the disease, while the H-2D-Q and H-2Ds alleles are associated with susceptibility. It is not clear whether Ir genes, or an alternative mechanism are responsible for the observed H-2-linked resistance to the disease.
D000818:Animals; D005796:Genes; D005799:Genes, Dominant; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains
D006649:Histocompatibility Antigens