Concentration of cyclic AMP in rat liver as a function of the insulin/glucagon ratio in blood under standardized physiological conditions.
The concentration of insulin and glucagon in peripheral blood and the concentration of cAMP in liver was followed in rats throughout a 48 hour starvation period and up to 6 hours afer refeeding glucose or casein. By so changing the insulin/glucagon molar ratio from minimum to maximum values, simultaneous inverse changes in the concentration of hepatic cAMP could be induced. The study, thus, suggests that during a starvation-refeeding cycle the level of cAMP in the liver is regulated predominantly by the insulin/glucagon ratio in the blood. Possible criticisms of this conclusion are discussed.
D000315:Adrenalectomy; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002364:Caseins / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D005934:Glucagon / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013217:Starvation
D001786:Blood Glucose; D002364:Caseins; D007328:Insulin; D005934:Glucagon; D000242:Cyclic AMP