Lymphocytosis-promoting factor of Bordetella pertussis: isolation, characterization, and biological activity.
The leukocytosis and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated in apparently pure form. LPF is a protein essentially free of lipid and carbohydrate with an estimated molecular weight of 67,000-73,600 daltons. Purified LPF induced both histamine sensitization and refractoriness to epinephrine-induced hyperglycemia and was a murine thymus-derived (T-) cell mitogen. Adenyl cyclase activity also appeared to be associated with LPF.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001426:Bacterial Proteins / Q000302:isolation & purification / Q000494:pharmacology; D001886:Bordetella pertussis; D004837:Epinephrine / Q000037:antagonists & inhibitors; D006632:Histamine / Q000633:toxicity; D007964:Leukocytosis / Q000139:chemically induced; D008213:Lymphocyte Activation; D008218:Lymphocytosis; D051379:Mice
D001426:Bacterial Proteins; D006632:Histamine; D000262:Adenylyl Cyclases; D004837:Epinephrine