Thymus-like activities of sulphur derivatives on T-cell differentiation.
Levamisole and sodium diethyldithiocarbamate can induce in vivo thymocyte differentiation from precursor spleen cells of nu/nu mice and evoke indirect plaque-forming cells in nude mice immunized with sheep red cells. These sulphur drugs induce in thymusless mice the production of a serum factor which transfer in vivo immune enhancement and in vitro thymocyte differentiation. In vivo treatment with sulphur derivative can substitute for an alleged thymice hormone.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001769:Blood / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects*; D004050:Ditiocarb / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007519:Isoantigens / Q000032:analysis; D007978:Levamisole / Q000494:pharmacology*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013859:Thiocarbamates / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology*
D007074:Immunoglobulin G; D007519:Isoantigens; D013859:Thiocarbamates; D007978:Levamisole; D004050:Ditiocarb