Translational regulatory mechanisms in neoplasia in vivo.
It is clear that regulation of genetic expression of cells need not involve alterations of the basic DNA structure. Between the production of messenger RNA and enzyme degradation there are a number of steps, any of which can be modulated by hormones and other factors to yield cellular abnormalities associated with malignancy. It is important to identify the exact step at which a carcinogen operates and to discover how this alteration is transmitted to the progeny of malignant cells.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D003609:Dactinomycin / Q000378:metabolism; D004790:Enzyme Induction; D005796:Genes; D005947:Glucose / Q000494:pharmacology; D008113:Liver Neoplasms / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D014366:Tryptophan Oxygenase / Q000096:biosynthesis
D012333:RNA, Messenger; D003609:Dactinomycin; D014366:Tryptophan Oxygenase; D005947:Glucose