title: Myocardial infarct imaging agents. III. Synthesis and evaluation of [203Hg] hydroxymercuriphthaleins.
abstract: Four Hg-203-mercurated phthaleins were prepared, purified, and compared with [203Hg] mercuric nitrate, [3H] phenolphthalein [203Hg] hydroxymercurifluorescein and Tc-99m-pyrophosphate in a rat model of myocardial necrosis to determine their specificities for damaged myocardium. The ratios of damaged myocardium to normal myocardium, and to blood, for the [203Hg] hydroxymercuriphthaleins (20.7-34.1 and 12.1-20.1, respectively) were somewhat lower than those reported previously for [203Hg] hydroxymercurifluorescein, but were higher than those found with [203Hg] mercuric nitrate, [3H] phenolphthalein, and Tc-99m pyrophosphate. Both the hydroxymercuri- functional group and the phthalein moiety are required for selectivity. The removal of the oxygen bridge present in fluorescein, and the replacement of carboxylic acid by sulfonic acid, had no significant effects on the sequestration process in damaged tissue.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D011756:Diphosphates; D006321:Heart / Q000000981:diagnostic imaging; D007553:Isotope Labeling; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008631:Mercury Radioisotopes; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009941:Organomercury Compounds; D010635:Phenolphthaleins; D011877:Radionuclide Imaging; D051381:Rats
chemical_list: D011756:Diphosphates; D008631:Mercury Radioisotopes; D009941:Organomercury Compounds; D010635:Phenolphthaleins; C015937:hydroxymercuriphthaleins