[Effect of psychotropic preparations on cyclic AMP phosphodiesterase activity in the rat cerebral cortex].
Effect of various psychotropic preparations on cAMP phosphodiesterase was studied. Almost all the psychotropic drugs studied were shown to inhibit the enzymatic activity. Neuroleptics--derivatives of phenothiazine and butyrophene--caused the strongest inhibitory effect.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats
D004791:Enzyme Inhibitors; D011619:Psychotropic Drugs; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Vliianie psikhotropnykh preparatov na aktivnost' fosfodiésterazy tsAMF kory golovnogo mozga krysy.