Small plaque variant transmissible gastroenteritis virus.
A small plaque (SP) variant transmissible gastroenteritis (TGE) virus strain that may be useful in the control of TGE in swine has been developed and tested. This strain was derived from a persistently infected swine leukocyte cell line originally infected with a virulent TGE virus. The SP viral strain was avirulent for 3-day-old susceptible pigs and pregnant gilts. The SP virus elicited protective antibody when inoculated into pregnant gilts oral/intranasally, or intramammarily, or by both of these routes. The morbidity and mortality of their passively immune suckling pigs were 62% and 14%, respectively.
D000818:Animals; D000917:Antibody Formation; D002478:Cells, Cultured; D003126:Colostrum / Q000276:immunology; D003332:Coronaviridae / Q000254:growth & development*; D005260:Female; D005761:Gastroenteritis, Transmissible, of Swine / Q000517:prevention & control; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D013552:Swine / Q000276:immunology; D005760:Transmissible gastroenteritis virus / Q000254:growth & development* / Q000276:immunology; D014774:Virulence