Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in Sprague-Dawley Rats.
Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals had liver tumors. The comparable responses to feeding of nitrosoazetidine-2,2,4,4-d4 were 3 of 21 rats with liver tumors at 0.69 millimolar and 3 of 30 rats with liver tumors at 0.17 mmol. These results show only a small deuterium isotope effect in liver carcinogenesis with nitrosoazetidine.
D000818:Animals; D001384:Azetidines / Q000008:administration & dosage / Q000633:toxicity*; D001385:Azetines / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D006224:Cricetinae; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000401:mortality; D009603:Nitroso Compounds / Q000008:administration & dosage / Q000633:toxicity*
D001384:Azetidines; D001385:Azetines; D009603:Nitroso Compounds