Thallium-201 distribution in the thyroid: relationship to thyroidal trapping function.
Experiments were undertaken to determine the behavior of thallium-201 in the thyroid in relation to the iodide-trapping mechanism in rats. Iodide trapping was compared to thyroidal thallium-201 trapping 30 minutes after intravenous injection. Thallium-201 uptake followed iodide uptake in control rats. TSH- and T3-treated rats but did not decrease in the same manner as iodide concentration in perchlorate-treated rats. These studies suggest that thallium-201 distribution in the thyroid may reflect the cationic side of the iodide pump or possible thyroidal blood flow.
D000818:Animals; D007454:Iodides / Q000378:metabolism; D008297:Male; D010472:Perchlorates / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D013793:Thallium / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism* / Q000502:physiology; D013972:Thyrotropin / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology
D007454:Iodides; D010472:Perchlorates; D011868:Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin; D013793:Thallium