title: Possible role of the proximal convoluted tubules of human kidney in chronic glomerulonephritis. A quantitative electron-microscopic study.
abstract: The amount of forming pinocytic (coated) microvesicles on the apical plasma membrane of kidney proximal tubule cells was assessed in kidney biopsies of 10 patients suffering from chronic glomerulonephritis. A significant correlation was found between the amount of these vesicles and diurnal proteinuria levels (r = 0.889; p less than 0.01). The possible mechanisms of protein reabsorption via pinocytosis in both normal and pathological conditions are considered.
mesh_terms: D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000648:ultrastructure; D002908:Chronic Disease; D002940:Circadian Rhythm; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology* / Q000503:physiopathology / Q000652:urine; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010873:Pinocytosis; D011506:Proteins / Q000378:metabolism; D011507:Proteinuria; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D011506:Proteins