Peripheral neuropathy caused by methaqualone.
Three patients are described who each received methaqualone and developed signs and symptoms of peripheral neuropathy. The subsequent improvement after cessation of methaqualone was highly suggestive or a direct toxic action of the drug or one of its metabolites. In one patient methaqualone was recommended with reappearance of signs and symptoms of peripheral neuropathy. Again cessation of the drug caused disappearance of these signs. There was no evidence whatsoever of any electrolyte or metabolic disturbance or any other pathology which might have given rise to this symptom complex. In addition, no other drugs were prescribed besides methaqualone.
D000328:Adult; D006801:Humans; D008297:Male; D008702:Methaqualone / Q000009:adverse effects*; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D008702:Methaqualone