Effect of arecoline on synaptosomal K+-phosphatase and (Na+ + K+)-ATPase.
Synaptosomal fractions and synaptosomal membranes from rat brain tissue were prepared and characterized enzymatically. Arecoline increased both the activity of K+-phosphatase in incubated synaptosomal fractions and the (Na+ + K+)-ATPase activity of synaptosomal membranes by 40% and 78%, respectively. This activation of ion transport processes is believed to be associated with increased ACh synthesis produced by arecoline.
D000109:Acetylcholine / Q000096:biosynthesis; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000032:analysis; D010042:Ouabain; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*
D009419:Nerve Tissue Proteins; D001115:Arecoline; D010042:Ouabain; D012964:Sodium; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D000109:Acetylcholine; D011188:Potassium