Suppression and immunotherapy of the guinea pig line-10 hepatocarcinoma mediated by nonviable Staphylococcus aureus.
Suppression of growth of the line-10 guinea pig hepatocarcinoma was achieved after the simultaneous injection of line-10 cells and heat-killed Staphylococcus aureus. Growth of tumor was also suppressed when line-10 cells were injected alone, contralaterally, at the same time as the vaccine mixture. Immunity developed to subsequent line-10 cell challenges but not to other syngeneic tumors. Similar results were obtained with the use of protein A-rich or -deficient strains of S. aureus. Multiple intratumor injections of heat-killed S. aureus were therapeutically effective against 6-day tumors. The antitumor effects of nonviable S. aureus were similar in many ways to those of living BCG or bacterial products suspended in oil droplets.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000628:therapy*; D006168:Guinea Pigs; D007167:Immunotherapy; D008113:Liver Neoplasms / Q000276:immunology / Q000628:therapy*; D008297:Male; D009374:Neoplasms, Experimental / Q000628:therapy; D013211:Staphylococcus aureus / Q000276:immunology*
D000951:Antigens, Neoplasm