[Electron microscopic demonstration of adenylate cyclase in rabbit small intestine enterocytes doubly stimulated by cholera toxin and sodium fluoride].
Cytochemical investigations showed adenylate cyclase in the rabbit small intestine enterocytes to be activated both with cholera toxin and sodium fluoride. Following double stimulation of adenylate cyclase in the intestinal enterocytes by the mentioned two substances maximal critical levels of cAMP were attained resulting in self-inhibition of adenylate cyclase; in this case only a low adenylate cyclase activity, if any, could be demonstrated by electron microscopy.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002771:Cholera / Q000201:enzymology / Q000378:metabolism; D002772:Cholera Toxin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004195:Disease Models, Animal; D004347:Drug Interactions; D005459:Fluorides / Q000494:pharmacology*; D006651:Histocytochemistry; D007421:Intestine, Small / Q000201:enzymology* / Q000378:metabolism; D008854:Microscopy, Electron; D011817:Rabbits; D012969:Sodium Fluoride / Q000494:pharmacology*
D012969:Sodium Fluoride; D002772:Cholera Toxin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D005459:Fluorides
Elektronno-mikroskopicheskoe vyiavlenie adenilattsiklazy énterotsitov tonkogo kishechnika krolikov pri dvoĭnom stimulirovanii kholernym toksinom i ftoristym natriem.