Effect of hyperprolactinemia on pituitary-adrenal function.
Three patients with hyperprolactinemia (2 with pituitary tumors and 1 with a hypothalamic disturbance) underwent evaluation of their hypothalamic-pituitary-adrenal axis using ACTH, metyrapone and in one case repetitive insulin tolerance tests. With the exception of a suggestion of a slight increase in adrenal responsiveness to pharmacological doses of ACTH in one of the patients, there was no alteration in the adrenal responsiveness of the 3 patients evaluated. We conclude that hyperprolactinemia probably does not systematically modify the responsiveness of the hypothalamic-pituitary-adrenal axis.
D000238:Adenoma, Chromophobe / Q000097:blood; D000324:Adrenocorticotropic Hormone; D000328:Adult; D001927:Brain Diseases / Q000097:blood; D005260:Female; D006801:Humans; D007031:Hypothalamus; D007328:Insulin; D008297:Male; D008797:Metyrapone; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood; D010912:Pituitary-Adrenal Function Tests; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011388:Prolactin / Q000097:blood*
D007328:Insulin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D008797:Metyrapone