Reduction of collagen biosynthesis in blood vessels and other tissues by reserpine and hypophysectomy.
Synthesis of collagen in the vasculature and other tissues of normotensive rats is markedly reduced by reserpine. Hypophysectomy produces similar effects. The effects of reserpine on collagen biosynthesis may be mediated through the hypothalamus.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D013006:Growth Hormone / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006909:Hydroxyproline / Q000652:urine; D007016:Hypophysectomy; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000378:metabolism
D012110:Reserpine; D013006:Growth Hormone; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline