The effect of the antiherpesvirus drug 5-methoxymethyl-2'-deoxyuridine on the humoral immune response in vivo.
5-Methoxymethyl-2'-deoxyuridine (MMUdR), a drug with potent antiviral activity in vitro against Herpes simplex virus, was investigated for its immunosuppressive effects. Doses as high as 2000mg/kg given daily for 9 days were not immunosupporessive as judged by the fact that treated animals produced normal immune responses to sheep erythrocytes, Brucella bacteria, and Herpes simplex virus.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000942:Antigens, Bacterial; D000956:Antigens, Viral; D000998:Antiviral Agents / Q000494:pharmacology*; D002003:Brucella abortus / Q000276:immunology; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D007166:Immunosuppressive Agents; D051379:Mice; D012756:Sheep / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D000942:Antigens, Bacterial; D000956:Antigens, Viral; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D003857:Deoxyuridine