Inhibition by somatostatin of adenosine-3',5'-monophosphate stimulated hepatic ribosomal protein synthesis.
Somatostatin which inhibits the secretion of various pituitary and intestinal hormones has been suspected to exert these effects by inhibiting adenosine-3',5'-monophosphate accumulation in the respective endocrine gland. Our results, obtained by cell free protein synthesis and by sedimentation through sucrose gradients of ribosomes, prepared from rat liver after incubation with cyclic AMP and/or somatostatin also suggest this antagonism between somatostatin and cyclic AMP. In addition, they indicate that this antagonism is not restricted to endocrine tissues.
D000818:Animals; D002474:Cell-Free System; D000242:Cyclic AMP / Q000494:pharmacology*; D004336:Drug Antagonism; D005260:Female; D008099:Liver / Q000378:metabolism; D051381:Rats; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D012270:Ribosomes / Q000187:drug effects*; D013004:Somatostatin / Q000494:pharmacology*
D012269:Ribosomal Proteins; D013004:Somatostatin; D000242:Cyclic AMP