Abrogation of antitumor effects of Corynebacterium parvum and BCG by antimacrophage agents: brief communication.
The consistently demonstrable antitumor effect of Corynebacterium parvum and BCG against a 7,12-dimethylbenz[a]anthracene-induced rat fibrosarcoma, growing either as a localized subcutaneous tumor or in ascites form, was abrogated by treatment of rats with antimacrophage agents such as silica or carrageenan.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology*; D005260:Female; D005354:Fibrosarcoma / Q000628:therapy; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000628:therapy*; D012822:Silicon Dioxide / Q000494:pharmacology*
D001500:BCG Vaccine; D001428:Bacterial Vaccines; D012822:Silicon Dioxide; D002351:Carrageenan