Vitamin D metabolism and the response to 1,25-dihydroxycholecalciferol in Osteoporosis.
The metabolism of isotopically-labelled cholecalciferol and the response to small doses of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) was studied in a group of women with osteoporosis presenting with crush vertebral fracture. No abnormality of vitamin D metabolism was detected. The administration of 1 microgram 1,25-(OH)2D3 for between 8 and 20 days was associated with an increased intestinal absorption and urinary excretion of calcium but caused no improvement in calcium balance. There was a small but significant rise in serum calcium and phosphorus and significant reduction in immunoassayable parathyroid hormone levels during treatment. It is concluded that 1,25-(OH)2D3 is unlikely to be of value in the management of osteoporosis.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000378:metabolism; D002762:Cholecalciferol / Q000097:blood*; D003404:Creatinine / Q000652:urine; D004100:Dihydroxycholecalciferols; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols; D007408:Intestinal Absorption; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D010710:Phosphates; D012709:Serum Albumin; D002762:Cholecalciferol; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium