Depression of multinucleation by interferon in simian virus 40-transformed cells treated with cytochalasin-B.
Multinucleation of simian virus 40-transformed mouse cells (mKS-A TU-7), which was induced by Cytochalasin-B, was depressed by the addition of crude interferon or by poly (riboinosinic)-poly(ribocytidylic) acid. In the absence of Cytochalasin-B, growth of the cells was not inhibited by interferon. Possible mechanism of this phenomenon is discussed.
D002460:Cell Line; D002467:Cell Nucleus / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003571:Cytochalasin B / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology*; D011070:Poly I-C / Q000494:pharmacology; D013539:Simian virus 40 / Q000502:physiology*
D003571:Cytochalasin B; D007372:Interferons; D011070:Poly I-C