title: Persistent and boosterable IgE antibody production in mice injected with low doses of ovalbumin and silica.
abstract: The results of the present experiments show that Aerosil, an amorphous submicroscopic silica, is able to stimulate in Swiss outbred mice the production of IgE antibodies to a single 1 microgram dose of Ovalbumin (OA) in experimental conditions in which detectable IgG1 antibodies were not produced. The production of IgE anti-OA antibodies stimulated by silica was persistent for a least 4 months, and demonstrated a secondary stimulation. Neither IgE nor IgG1 anti-OA antibodies were demonstrable when mice were immunized with OA alone or OA with aluminum hydroxide.
mesh_terms: D000536:Aluminum Hydroxide / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis; D051379:Mice; D010047:Ovalbumin / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D012822:Silicon Dioxide / Q000276:immunology*; D013997:Time Factors
chemical_list: D000941:Antigens; D007073:Immunoglobulin E; D000536:Aluminum Hydroxide; D012822:Silicon Dioxide; D010047:Ovalbumin