A chromosomal translocation causing overproduction of iso-2-cytochrome c in yeast.
The CYC7-1 mutation in the yeast Saccharomyces cerevisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c. Genetic analysis established that the CYC7-1 mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVI. The chromosome V arm was broken adjacent to the gene CYC7, which determines the primary structure of iso-2-cytochrome c, and this fragment containing the CYC7 gene was joined to the segment of chromosome XVI. It appears as though the elevation of iso-2-cytochrome c is caused by an abnormal controlling region adjacent to the structural region of the CYC7 gene.
D003574:Cytochrome c Group / Q000096:biosynthesis / Q000235:genetics*; D005796:Genes; D005809:Genes, Regulator; D008040:Genetic Linkage; D009154:Mutation; D012441:Saccharomyces cerevisiae; D014178:Translocation, Genetic
D003574:Cytochrome c Group