Accumulation of cyclic adenosine 3',5'-monophosphate in human cerebellar cortex slices: effect of monoamine receptor agonists and antagonists.
Noradrenaline, isoproterenol, adrenaline or clonidine stimulate cyclic AMP formation in human cerebellar cortex 15-20 fold and serotonin or dopamine 3-fold. The increase by noradrenaline or clonidine is dose-dependent. Propranolol completely blocks the increase induced by noradrenaline or isoproterenol but not that by clonidine. Phentolamine was ineffective in blocking cyclic AMP formation induced by noradrenaline, isoproterenol, adrenaline or clonidine. Chlorpromazine completely blocked the increase induced by noradrenaline, isoproterenol, clonidine, serotonin or dopamine.
D000293:Adolescent; D002525:Cerebellar Cortex / Q000187:drug effects* / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis*; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D000242:Cyclic AMP; D007545:Isoproterenol; D003000:Clonidine; D002746:Chlorpromazine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine