Latent herpes simplex virus in ganglia of mice after primary infection and reinoculation at a distant site.
Herpes simplex virus (HSV)-infected hairless mice with evidence of latent infection in spinal ganglia did not develop latent HSV infections in trigeminal ganglia upon reinfection in the oro-facial area. HSV-infected and PAA-treated mice without evidence of latent HSV infection in spinal ganglia were resistant to reinfection in the lumbar region, but not to that performed in the oro-facial area.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002493:Central Nervous System Diseases / Q000276:immunology; D005724:Ganglia; D005727:Ganglia, Spinal; D006561:Herpes Simplex / Q000276:immunology*; D007109:Immunity; D051379:Mice; D008819:Mice, Nude; D010746:Phosphonoacetic Acid / Q000494:pharmacology; D018139:Simplexvirus / Q000276:immunology
D000914:Antibodies, Viral; D010746:Phosphonoacetic Acid