Identification of thorium dioxide in human liver cells by electron microscopic x-ray microanalysis.
Thirty-two years after injection of thorium dioxide (Thorotrast) for diagnostic x-ray studies in a female patient deposits were found by light microscopy in the liver macrophages (Kupffer cells). They were shown by electron microscopy to be located inside secondary lysosomes, and by autoradiography and x-ray microanalysis they were identified as thorium.
D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000032:analysis / Q000648:ultrastructure*; D008875:Middle Aged; D013911:Thorium Dioxide / Q000032:analysis*
D013911:Thorium Dioxide