[Treatment of essential hypertension with propranolol (author's transl)].
Effect of long-term administration of propranolol was studied in 90 unselected patients with essential hypertension. At a dose of 180 and 360 mg daily it dropped the blood pressure to at least 155/95 mm Hg in 31 patients (34.4%). Those who responded to propranolol had lower systolic and diastolic blood pre-treatment pressures than those who failed, were younger by an average of eight years, and in no case had decreased plasma-renin activity and demonstrated greater plasma-renin activity after furosemide. After a titration phase with increasing doses of propranolol those who responded were treated in a crossed double-blind test with propranolol or placebo. There was a significant difference in systolic blood pressure (standing and lying) and diastolic pressure (standing) between the two. There was also a highly significant difference in heart rate. During chronic beta blockade the basal and stimulated plasma-renin activity fell. But percentage stimulation of renin secretion was fully maintained. However, aldosterone response was decreased. Serum potassium rose slightly but significantly, cAMP  24-hour urine excretion fell significantly. Electrolyte excretion did not differ between the two treatment periods.
D000328:Adult; D000367:Age Factors; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000652:urine; D000242:Cyclic AMP / Q000652:urine; D005665:Furosemide / Q000494:pharmacology; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D008875:Middle Aged; D010919:Placebos; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood; D013997:Time Factors
D010919:Placebos; D000450:Aldosterone; D005665:Furosemide; D012964:Sodium; D011433:Propranolol; D003404:Creatinine; D000242:Cyclic AMP; D012083:Renin; D011188:Potassium
Die Behandlung der essentiellen Hypertonie mit Propranolol