9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.
Of a series of nucleoside analogues synthesised, 9-(2-hydroxyethoxymethyl) guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low toxicity.
D000818:Animals; D000998:Antiviral Agents; D001711:Biotransformation; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D006168:Guinea Pigs; D006564:Herpesviridae / Q000187:drug effects*; D006566:Herpesviridae Infections / Q000188:drug therapy*; D007635:Keratitis, Dendritic / Q000188:drug therapy; D051379:Mice; D011817:Rabbits
D000998:Antiviral Agents; D006147:Guanine