title: Irradiation induced kyphosis.
abstract: Eighty-one patients with Wilms tumor treated by irradiation and chemotherapy were studied. Despite the fact that multiple portals for irradiation were used, each crossing the midline, the amount of irradiation delivered to different parts of the vertebral body varied and it was this variation in delivered dose which produced axial skeletal deformities in 70% of the patients. Of the 57 patients with these deformities 32 had scoliosis, 22 kyphoscoliosis and 3 patients pure kyphosis; 12 patients had a kyphotic deformity of over 25 degrees, 7 patients requiring surgical correction. A high incidence of pseudarthrosis following posterior fusion has led to the preference of a 2-stage procedure, anterior interbody fusion followed by a posterior fusion with Harrington rods after 2 weeks of correction in halo femoral traction.
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy; D007738:Kyphosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D011183:Postoperative Complications; D019736:Prostheses and Implants / Q000009:adverse effects; D011832:Radiation Injuries / Q000150:complications*; D012600:Scoliosis / Q000209:etiology / Q000601:surgery; D013123:Spinal Fusion / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000209:etiology; D009396:Wilms Tumor / Q000532:radiotherapy