title: [Changes of the phospholipid bilayer structure under the adsorption of ferricytochrome c on its surface].
abstract: Changes in the mobility of phospholipid molecules in liposomes membranes under adsorption ferricytochrome c on its surface were studied by means of NMR and EPR spectroscopy. It is found that the interaction of cytochrome molecules with vesicles causes the broadening of 1H-NMR signals of hydrophobic as well as polar groups in cardiolipin and phosphatidylcholine in the presence of lauric or phosphatidic acid. This broadening of 1H-NMR signals in hydrophobic groups may be caused by decrease in the rate of lateral diffusion of phospholipid molecules. The changes in the correlation time of hydrophobic spin-proub in liposomes containing phosphatydiloholine and cardiolipin with the increase of ferricytochrome c concentration were also observed. These changes suggest that the formation of protein-phospholipid clusters results in the impair of the regular structure of phospholipid bilayer.
mesh_terms: D000327:Adsorption; D002308:Cardiolipins; D055598:Chemical Phenomena; D002621:Chemistry; D003574:Cytochrome c Group; D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids; D013499:Surface Properties
chemical_list: D002308:Cardiolipins; D003574:Cytochrome c Group; D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids
vernacular_title: Izmenenie struktury fosfolipidnogo bisloia pri adsorbtsii ferritsitokhroma c na ego poverkhnosti