[Urinary excretion kinetics of enzymes and proteins in the application of therapeutic doses of gentamycin].
9 patients with chronic pyelonephritis were given gentamicin intramuscularly in an appropriate dosage for a period of 10 days. The urinary excretion of cells, protein, alanine aminopeptidase (EC 3.4.11.2),N-acetylglucosaminidase(EC 3.2.1.30) and alpha-galactosidase (EC 3.2.1.23) was determined daily. The most striking enzyme increase occurred in alanine aminopeptidase. The enzyme and protein output appears to be rhythmic and discontinuous. A 2--3-day rhythm is suggested. Rhythmic alterations of the digestion activity of the lysosomes are assumed to be the cause of these changes.
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000626:Aminopeptidases / Q000652:urine; D004798:Enzymes / Q000652:urine*; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D011507:Proteinuria / Q000175:diagnosis*; D011704:Pyelonephritis / Q000188:drug therapy; D000519:alpha-Galactosidase / Q000652:urine
D004798:Enzymes; D005839:Gentamicins; D000519:alpha-Galactosidase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases
Ausscheidungskinetik von Enzymen und Protein mit dem Harn bei Applikation therapeutischer Gentamycindosen.