[Effect of the prolonged administration of the atherogenic fractions of lipoproteins on the blood and myocardial lipid picture in rabbits].
Homologous total fraction of pre-beta and beta-lipoproteins, isolated from intact animal blood and administered intravenously into rabbits within 1.5-2 months, caused distinct alterations in lipid spectra of rabbit-recipient blood serum. The phenomenon was manifested as an increase in concentration of all the lipid components in blood plasma, elevation in content of pre-beta and beta-lipoproteins in blood and decrease in content of alpha-lipoproteins. The alterations were apparently related not only to excessive administration of atherogenic lipoproteins but to impairments in lipid metabolism, similar to lipoproteinemia, reproduced in other experiments.
D000818:Animals; D006321:Heart / Q000187:drug effects*; D006949:Hyperlipidemias / Q000378:metabolism; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL
Vliianie dlitel'nogo vvedeniia aterogennykh fraktsii lipoproteidov na lipidogrammu krovi i miokarda krolikov.