[Degradation of C1q, the first subcomponent of the complement sequence, by synovial collagenase from patients with rheumatoid arthritis (author's transl)].
Human C1q is shown to be degraded by high concentrations of RA synovial collagenase (enzyme : substrate ratio 2 : 1). The collagen-like sequence of C1q is attacked by the enzyme. A possible cleavage site is described and compared with the cleavage site in collagen.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D003013:Clostridium / Q000201:enzymology; D003172:Complement C1 / Q000378:metabolism*; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D003012:Microbial Collagenase / Q000378:metabolism*; D013583:Synovial Membrane / Q000201:enzymology
D003172:Complement C1; D003012:Microbial Collagenase; D006909:Hydroxyproline
Abbau von C1q, der ersten Subkomponente des Komplementsystems, durch Synovialkollagenase von Patienten mit primär chronischer Polyarthritis.