title: [Analysis of mutation frequency following continuous and fractionated application of ethyleneimine and ethyl methanesulfonate to male sex cells of Drosophila melanogaster].
abstract: The increase in the frequency of recessive lethal sex-linked mutations induced by fractionated effect of ethylene imine (EI) an ethylmethanesulphonate (EMS) on mature sperm of Drosophila melanogaster was observed and compared uith prolonged treatment (8h) and with the additive effect. This effect of dose fractionation was observed in the case of the treatment of sperms in male gonads and in female spermathecas. The increase of the mutation frequency was noted by brood-pattern method after fractionated treatment of spermatocytes and spermatogonia only with EMS. This increase was not observed under the effect of EI on spermatocytes and spermatogonia because of the high sierilization activity of EI. Possible mechanisms of the effects observed are discussed.
mesh_terms: D000818:Animals; D001388:Aziridines / Q000008:administration & dosage*; D001389:Azirines / Q000008:administration & dosage*; D004331:Drosophila melanogaster; D005020:Ethyl Methanesulfonate / Q000008:administration & dosage*; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D008698:Mesylates / Q000008:administration & dosage*; D009153:Mutagens / Q000008:administration & dosage*; D009154:Mutation; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D001388:Aziridines; D001389:Azirines; D008698:Mesylates; D009153:Mutagens; D005020:Ethyl Methanesulfonate
vernacular_title: Analiz chastoty mutatsiĭ pri nepreryvnom i fraktsionirovannom deĭstvii étilenimina i étilmetansul'fonata na muzhskie polovye kletok Drosophila melanogaster.