[Characteristics of the functional maturity of the insular apparatus of the human pancreas during intrauterine development].
The reactivity of human foetal pancreas was determined by the increase of insulin secretion in vitro in response to the effect of glucose, arginine, theophylline, cyclic AMP and somatotrophic hormone (STH). The results of the experiments have shown that the beta-cells of the islet system in the pancreas of 7-9 weeks old embryos are as yet not able to respond to the main physiological stimulus, glucose, but respond already to cAMP, STH, arginine with glucose. The glands of 10-14 weeks old foetuses are already able to react to glucose and respond to all other stimuli, except arginine. Taken for comparison, the glands of 19-22 weeks old foetuses respond to glucose by the increase of insulin secretion.
D001120:Arginine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D008297:Male; D013268:Stimulation, Chemical; D013806:Theophylline / Q000494:pharmacology
D007328:Insulin; D013006:Growth Hormone; D001120:Arginine; D013806:Theophylline; D000242:Cyclic AMP; D005947:Glucose
K kharakteristike funktsional'noĭ zrelosti ostrovkovogo apparata podzheludochnoĭ zhelezy cheloveka vo vnutriutrobnom razvitii.