Cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys.
Intravenous dose-response relationships for dimethyl tubocurarine showed that vagal blockade only became appreciable (50-83%) at doses 8-16 times those sufficient for full neuromuscular paralysis in anaesthetized cats (0.0625 mg/kg) and rhesus monkeys (0.125 mg/kg); heart rate was unchanged. Sympathetic function was unimpaired by supramaximal paralysing doses of 0.5 and 1 mg/kg in cats, but was reduced (20-41%) by comparable neuromuscular paralysing doses of 1 and 2 mg/kg in rhesus monkeys; these doses decreased carotid arterial pressure by 22-36%. The duration of action of dimethyl tubocurarine was prolonged; more than 60 min was required for recovery from full neuromuscular paralysis; the drug was even more persistent in rhesus monkeys than in cats. Thus the need remains for a drug resembling dimethyl tubocurarine in its highly specific action at the neuromuscular junction, but with a much shorter duration of action.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D006339:Heart Rate / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D009407:Nerve Block; D009469:Neuromuscular Junction / Q000187:drug effects*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors; D014403:Tubocurarine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D014403:Tubocurarine