Chemotherapeutic compounds and Acanthamoebae from eye infections.
The amoebicidal and amoebistatic action in vitro of 24 compounds was tested on two strains of Acanthamoeba, A. polyphaga and A. castellanii, isolated from eye infections in this country. For comparison, the Ryan strain of A. castellanii and Naegleria gruberi L-1 were also examined. Nine compounds showed sufficient activity to merit further consideration, ie, acriflavine, proflavine, hydroxystilbamidine isethionate, paromomycin, miconazole, amphoterin, neomycin, polymyxin, and the last two combined in Neosporin.
D000167:Acriflavine / Q000494:pharmacology; D000563:Amebicides / Q000494:pharmacology*; D056890:Eukaryota / Q000187:drug effects*; D005128:Eye Diseases / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology; D011113:Polymyxins / Q000494:pharmacology
D000563:Amebicides; D011113:Polymyxins; D000167:Acriflavine; D009355:Neomycin