Investigations on the suitability of mice for potency testing of FMD vaccines.
Potency testing of FMD vaccines by a three-point method was elaborated. Mice myotropic FMD virus was used as challenge virus. With this test the immunogenicity of FMD vaccines based on BHK, calf kidney or swine kidney was examined. The results are reproducible and allow quantification of the antigenic value of FMD vaccines within statistical limits.
D000818:Animals; D000917:Antibody Formation; D005537:Aphthovirus / Q000254:growth & development / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D008297:Male; D051379:Mice / Q000276:immunology*; D014765:Viral Vaccines / Q000302:isolation & purification / Q000592:standards*
D014765:Viral Vaccines