Spontaneous esophageal carcinoma and epithelial cell line of an adult rhesus monkey.
A continuous epithelial cell line, 816A, was established from a lymph node of an adult rhesus monkey with metastatic esophageal carcinoma. These cells are characterized by the presence of desmosomes and a markedly heteroploid karyotype. At a relatively early culture age, electron microscopy showed both budding and extracellular type C virus. Antigen reactive with antisera to Mason-Pfizer monkey virus was observed by complement-fixation. The level of this antigen decreased with increased culture age. To our knowledge, the 816A cells represent the only established simian or human cell line of esophageal carcinoma origin.
D000818:Animals; D000956:Antigens, Viral; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D002460:Cell Line; D002869:Chromosome Aberrations; D004848:Epithelium / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology*; D000882:Haplorhini; D007181:Inclusion Bodies, Viral; D008253:Macaca mulatta; D008854:Microscopy, Electron; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000473:pathology; D012190:Retroviridae / Q000276:immunology
D000956:Antigens, Viral