Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice.
ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78% incidence of acute and latent infection compared with a 1.7% incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.
D000208:Acute Disease; D000818:Animals; D006561:Herpes Simplex / Q000517:prevention & control*; D007114:Immunization; D051379:Mice; D008813:Mice, Inbred ICR; D012703:Serotyping; D018139:Simplexvirus / Q000276:immunology*; D013997:Time Factors