[Increase in the antiviral resistance of cells after treating them with messenger RNA for antiviral protein].
The authors studied antiviral resistance of murine cells L-929 following single introduction into them of homologous and heterologous informative RNA preparations for antiviral protein (i-RNA-AVP). As shown, in using homologous i-RVA-AVP preparations suppression of the virus production constituted 90--93%, and was stably traced in cell passage in the course of 1 1/2 months (observation period). Following cell contact with heterologous i-RNA-AVP preparations suppression the first 6 passages of the virus production constituted about 90%, rising by the 16th passage to 99.9%. The data obtained pointed to the possibility of stable increase of cell antiviral resistance with the aid of i-RNA-AVP, this could serve as a new effective method of nonspecific cell protection from the viruses.
D000818:Animals; D002478:Cells, Cultured; D004685:Encephalomyelitis, Venezuelan Equine / Q000517:prevention & control; D005347:Fibroblasts; D007739:L Cells; D051379:Mice; D012333:RNA, Messenger / Q000627:therapeutic use*; D013280:Stomatitis / Q000517:prevention & control; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000517:prevention & control*
D012333:RNA, Messenger
Povyshenie protivovirusnoĭ rezistentnosti kletok posle vvedeniia v nikh informatsionnoĭ RNK dlia antivirusnogo belka.