Bradykinin action in the rat duodenum through the cyclic AMP system.
Activators of the adenylate cyclase or inhibitors of the cAMP-phosphodiesterase, respectively, potentiate the bradykinin-induced relaxation of the rat duodenum, whereas imidazole as a stimulator of the cAMP-phosphodiesterase reduces the relaxation. The experiments indicate a linkage between the adenylate cyclase system with the biological action of bradykinin on the rat duodenum. In contrast, no similar effect has been observed on the rat uterus.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D000242:Cyclic AMP / Q000502:physiology*; D004386:Duodenum / Q000648:ultrastructure; D004546:Elapid Venoms / Q000494:pharmacology; D005260:Female; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000648:ultrastructure
D004546:Elapid Venoms; D007093:Imidazoles; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases; D001920:Bradykinin