title: Possible relationship between the activity of the adrenal gland and the subcommissural organ in the lizard Lacerta s. sicula Raf. Effects of ACTH Administration during winter.
abstract: In order to study the possible functional relationship between the adrenal gland and the subcommissural organ (SCO) in the lizard Lacerta s. sicula Raf., ACTH was administered to some specimens of this species in January when both the adrenal gland and the subcommissural organ have a very low activity. In comparison to untreated controls, the adrenals of animals treated with ACTH showed clear signs of stimulation, presenting enlarged blood vessels, very few lipid droplets, numerous polymorphic mitochondria and abundant tubular smooth endoplasmic reticulum. In addition, a distinct increase in secretory material was observed in the subcommissural cells of specimens treated with ACTH. These cells showed large cisternae of the rough endoplasmic reticulum filled with granular material in the basal region, numerous secretory granules of two types in the paical region and a reduced number of microvilli on the free cell surface. These findings, together with the results of preceding studies, lead the authors to the consideration that steroid hormones might play a role in the regulation of the secretory activity of the SCO.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003080:Cold Temperature; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D008116:Lizards / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D012621:Seasons; D013351:Subcommissural Organ / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000324:Adrenocorticotropic Hormone