Intracellular lambda light chain inclusions in chronic lymphocytic leukaemia.
A case of chronic lymphocytic leukaemia (CLL) with intracytoplasmic crystalline inclusions in peripheral blood lymphocytes is presented. The inclusions were identified as crystals of lambda (lambda) light chain and were present in bone marrow derived (B-cells) lymphocytes. The occurrence of light chain crystals in CLL may reflect a more primitive defect in immunoglobulin (Ig) synthesis, intracellular transport or secretion than has previously been reported.
D000368:Aged; D001402:B-Lymphocytes / Q000648:ultrastructure; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D002479:Inclusion Bodies / Q000032:analysis* / Q000648:ultrastructure; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains