Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine.
The effect of immunization with inactivated herpes virus vaccines, including a vaccine free of all nucleic acid, was investigated in a mouse model system. Protection against oral lesions induced by herpes simplex virus type 1 was demonstrated by several criteria: (i) reduction in the incidence and severity of primary oral lesions; (ii) decrease in acute and latent infection of the regional sensory ganglia; and (iii) protection from viral encephalitis and death. The immune response of mice to the vaccine and to subsequent virus challenge was measured by following serum-neutralizing antibody titers.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral; D003851:Deoxyribonucleases / Q000378:metabolism; D004671:Encephalitis, Arbovirus / Q000517:prevention & control; D005724:Ganglia / Q000382:microbiology; D006561:Herpes Simplex / Q000517:prevention & control*; D007114:Immunization; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D003851:Deoxyribonucleases