Distinct dopaminergic systems in ACTH-induced grooming.
Excessive grooming behavior induced in rats by intraventricular injection of ACTH1-24 was inhibited by selective pharmacological manipulation of two functionally distinct types of dopaminergic terminals (DAe and DAi) in the neostriatum or the nucleus accumbens. It is concluded that when ACTH1-24 produces the behavioral response it modulates the activity of both the DAe and the DAi systems.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004874:Ergonovine / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats
D000324:Adrenocorticotropic Hormone; D006220:Haloperidol; D004298:Dopamine; D004874:Ergonovine