A new histochemical approach to olfactory esthesioneuroma. A nasal tumor of neural crest origin.
A close collaboration between E.N.T. surgeons and pathologists permitted us to obtain 6 cases of olfactory esthesioneuroma in which fresh tumor tissue was available. Histochemical and biochemical studies were made in comparison with neuroblastoma. Different reactions and assays performed revealed a similarity with sympathetic tumors. Moreover, the presence of catecholamines in esthesioneuroma provides a great help in diagnostic as does electron microscope examination.
D002395:Catecholamines / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D004950:Esterases / Q000378:metabolism; D006801:Humans; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000378:metabolism* / Q000648:ultrastructure; D009669:Nose Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D010088:Oxidoreductases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism
D002395:Catecholamines; D010088:Oxidoreductases; D004299:Dopamine beta-Hydroxylase; D004950:Esterases; D010744:Phosphoric Monoester Hydrolases; D010450:Endopeptidases