[Effect of hyperoxia on triacylglycerol lipase activity of the rat lung (author's transl)].
An investigation of acid and neutral triacylglycerol lipases in rat lung tissue has been carried out. The effect of high oxygen concentration in the inspired gas mixture on the activities of the two triacylglycerol lipases has been studied. Hyperoxia had a strong inhibitory effect on both enzymes, the degree of inhibition being dependent on the duration of exposure. Dibutyryl-3',5' AMP and NaF restored completely the activities of the inhibited triacylglycerol lipases, while adrenaline and caffeine had no effect. The possible mechanisms of the effects of oxygen on lung triacylglycerol lipases are discussed.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D004793:Enzyme Reactivators; D004837:Epinephrine / Q000494:pharmacology; D006931:Hyperbaric Oxygenation; D007700:Kinetics; D008049:Lipase / Q000037:antagonists & inhibitors*; D008168:Lung / Q000201:enzymology* / Q000294:innervation; D008297:Male; D010100:Oxygen / Q000009:adverse effects; D051381:Rats; D011953:Receptors, Cyclic AMP; D012969:Sodium Fluoride / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism
D000067956:Adenylyl Cyclase Inhibitors; D004793:Enzyme Reactivators; D011953:Receptors, Cyclic AMP; D014280:Triglycerides; D002110:Caffeine; D003994:Bucladesine; D012969:Sodium Fluoride; D008049:Lipase; D010100:Oxygen; D004837:Epinephrine
Effet de l'hyperoxie sur l'activité des triacylglycérol lipases pulmonaires de rat.