[Experimental nephrotic syndrome in the rat. Biologic parameters and study of several hydrolases in different purified kidney fractions].
The induction of nephrotoxic nephritis in rats with rabbit antibodies preparation results in proteinuria, hypoproteinemia and hyperlipidemia with little glomerular lesions. A study of some hydrolases in cortex and medulla on one hand and glomerular and tubules on the other, showed changes in the activities of following enzymes. 1) A 20-30 % decrease in Na+, K+ dependent ATP-ase in whole kidney. 2) A 20 % decrease in beta-galactosidase activity in glomerular and medulla. 3) A 20 % increase of arylsulphatase A activity in tubules. These results are discussed in the light of the present knowledge of sulphatide metabolism in kidney.
D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D001323:Autoantibodies / Q000008:administration & dosage; D004195:Disease Models, Animal; D004950:Esterases / Q000378:metabolism*; D007668:Kidney / Q000503:physiopathology; D009404:Nephrotic Syndrome / Q000201:enzymology* / Q000276:immunology / Q000652:urine; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011507:Proteinuria / Q000150:complications; D051381:Rats; D001616:beta-Galactosidase / Q000378:metabolism
D001323:Autoantibodies; D004950:Esterases; D010744:Phosphoric Monoester Hydrolases; D001192:Arylsulfatases; D001616:beta-Galactosidase
Syndrome néphrotique expérimental chez le rat. Paramètres biologiques et études de quelques hydrolases dans diverses fractions purifiées du rein.