Antagonism by PGF2alpha of the vasodilation induced by PGE1, PGE2 and PGA1 in the canine uterus.
Prostaglandins appear to play an important role in a number of reproductive processes. The present study was designed to determine if the vasodilator action of prostaglandins of the A and E series on uterine vascular smooth muscle was mediated via a receptor and if PGF2alpha could compete for this same receptor. The data demonstrate that PGF2alpha, which by itself has no uterine vascular effect, can produce a parallel shift in the dose-response curves for certain vasodilator prostaglandins. This action, which suggests competitive antagonism, may well play a role in regulating blood flow in the nonpregnant uterus.
D000818:Animals; D004285:Dogs; D005260:Female; D009130:Muscle, Smooth / Q000187:drug effects; D011454:Prostaglandins A / Q000037:antagonists & inhibitors*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D011460:Prostaglandins F / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D014599:Uterus / Q000098:blood supply*; D014666:Vasomotor System / Q000187:drug effects*
D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin