Induction of hepatic tumors in a teleost (Oryzias latipes) after treatment with methylazoxymethanol acetate: brief communication.
Liver neoplasms including trabecular hepatoma and cholangioma were induced in medakas (Oryzias latipes) by the addition of methylazoxymethanol acetate to their aquarium water at levels of 0.1-3 ppm for periods ranging from 1 to 120 days. More than 80% of the surviving fish developed tumors at 3 or 5 months after commencement of the treatment, irrespective of levels of the drug, when appropriate times of exposure were chosen.
D002759:Adenoma, Bile Duct / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology; D005260:Female; D005399:Fishes; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate