Effect of vinblastine on pancreatic enzymes secretion induced by cyclic nucleotide derivatives.
Vinblastine did not affect the basal secretion of enzymes from the rat pancreas, but it potentiates the secretory response to dibutyryl cyclic AMP. This potentiation is confirmed by the observation of numerous pictures of exocytosis at the apical part of the acinar cell. Dibutyryl cyclic GMP by itself, or associated with vinblastine, failed to modify the spontaneous release of enzymes or the secretion induced by dibutyryl cyclic AMP.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D066298:In Vitro Techniques; D008049:Lipase / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D003994:Bucladesine; D008049:Lipase; D000681:Amylases; D006152:Cyclic GMP