Presence of leucocyte inclusions in spleen and bone marrow of patients with Felty's syndrome.
The spleens from two patients with Felty's syndrome and the bone marrow from one patient with Felty's syndrome were examined for the presence of intracytoplasmic inclusions in neutrophils when stained with antibodies to IgG, IgM, IgA, and betalc. Four normal spleens from trauma patients were similarly examined. In both spleens and the bone marrow from the Felty patients, large inclusions were noted. In none of the four normal spleens were large inclusions present. These studies suggest that phagocytosis of immune complexes by neutrophils in Felty patients may induce sequestration of these cells in the spleen and bone marrow.
D001853:Bone Marrow / Q000473:pathology* / Q000648:ultrastructure; D005258:Felty Syndrome / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins; D002479:Inclusion Bodies; D007962:Leukocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000648:ultrastructure; D013154:Spleen / Q000473:pathology* / Q000648:ultrastructure
D007136:Immunoglobulins