The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain.
Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the anti-schizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenaline-sensitive cyclic AMP accumulation.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D000242:Cyclic AMP / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013574:Synaptosomes / Q000378:metabolism
D008094:Lithium; D000242:Cyclic AMP; D004298:Dopamine; D009638:Norepinephrine