Activity of chromatin-bound protease from rat liver and Morris hepatomas.
1. The activity of serine protease was studied in chromatin and in histone preparations from rat liver and Morris hepatomas, lines 5123 D and 7777. 2. Electrophoretic patterns of histones and the amounts of acid-soluble peptides released during incubation of chromatin and histones showed that there was no significant correlation between protease activity and tumour differentiation and its growth rate.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D002454:Cell Differentiation; D002460:Cell Line; D002843:Chromatin / Q000201:enzymology; D006657:Histones / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology*; D009374:Neoplasms, Experimental / Q000201:enzymology; D010447:Peptide Hydrolases / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats
D002843:Chromatin; D006657:Histones; D010447:Peptide Hydrolases