title: Effect of epinephrine on the oxidative desaturation of fatty acids in the rat.
abstract: The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal preparations of rats has been studied. Administration of epinephrine (1 mg/kg body weight) produced a significant decrease in desaturation of [l-14C]=linoleic acid to gamma-linolenic acid and of [L-14C]alpha-linolenic acid to actadeca-6,9,12,15-tetraenoic acid 12 hr after the infection. Lower doses produced a lesser effect on the delta6-desaturation activity. Epinephrine administration modified the V max of linoleic acid desaturation but not the K m. There was also a slight increase in palmityl desaturation activity. The effect of epinephrine on delta6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit delta6-desaturation activity.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008041:Linoleic Acids / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism; D051381:Rats
chemical_list: D001786:Blood Glucose; D008041:Linoleic Acids; D008112:Liver Glycogen; D010169:Palmitic Acids; D000242:Cyclic AMP; D044943:Fatty Acid Desaturases; D004837:Epinephrine