Effects of selenium on azo dye hepatocarcinogenesis.
Groups of male Sprague--Dawley rats were maintained on three regimens: I. basal diet plus 0.05% 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB), II. same as I plus 6 ppm selenium (Na2SeO3) in the drinking water, and III. same as I plus 6 ppm selenium added to the diet in the form of a high selenium yeast. The 3'-MeDAB was incorporated in the diet for 8 weeks and then removed. The selenium supplements in Groups II and III were continued for an additional 4 weeks. At sacrifice the liver tumor incidence from was ascertained as the ratio of animals with tumors/total number of surviving animals per group. Selenium reduced the incidence  from 92% (11/12) in the Group I control, to 46% (7/15) in Group II and to 64% (9/14) in Group III.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008749:Methyldimethylaminoazobenzene / Q000037:antagonists & inhibitors*; D051381:Rats; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives*
D001551:Benz(a)Anthracenes; D008749:Methyldimethylaminoazobenzene; D004124:p-Dimethylaminoazobenzene; D012643:Selenium