title: Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase.
abstract: The inhibitory activity of 19 flavonoid molecules on cyclic AMP breakdown by a commercial beef heart phosphodiesterase preparation is reported. 7 compounds are active in the micromolar range, 2 of which have a potency equivalent to that of papaverine. Some structure activity relationships are drawn.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D015105:3',5'-Cyclic-AMP Phosphodiesterases