Correlation of virus polypeptide structure with attenuation of poliovirus type 1.
Several avirulent samples of poliovirus type 1 derived in the process attenuating the neurovirulent Mahoney strain show an altered virus capsid polypeptide, VP-1, on polyacrylamide gel electrophoresis of sodium dodecyl sulfate-disrupted virions.
D002213:Capsid / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D017955:Poliovirus / Q000032:analysis / Q000254:growth & development / Q000472:pathogenicity*; D011054:Poliovirus Vaccine, Inactivated; D014613:Vaccines, Attenuated; D014764:Viral Proteins / Q000032:analysis*; D014774:Virulence; D014776:Virus Cultivation
D010455:Peptides; D011054:Poliovirus Vaccine, Inactivated; D014613:Vaccines, Attenuated; D014764:Viral Proteins