Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses.
Natural tumor incidence and type C virus expression in HIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of lymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.
D000367:Age Factors; D000818:Animals; D000956:Antigens, Viral; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D012190:Retroviridae / Q000276:immunology; D013045:Species Specificity; D014779:Virus Replication
D000956:Antigens, Viral