Systems simulation: theory of monosynaptic transfer between neuron populations.
This paper presents a theory for the input-output transformation involved in diffuse monosynaptic activation in a neural tissue or organ system of one population of neurons by another. Main findings are: (1) highly diffuse monosynaptic linkages act very much like filters, selectively sensitive to synchronized clusters of action potentials among the fibers of the input population; (2) partially diffuse monosynaptic linkages are capable of effecting either an amplification or diminution of the number of pulses involved in a single synchronized cluster, depending on parameters of the system; and (3) partially diffuse and spatially organized monosynaptic linkages are capable of effecting a spatial inversion of fine-grained spatial patterns. Theoretical predictions are clarified by mathematical analysis and computer simulation.
D000200:Action Potentials; D000344:Afferent Pathways / Q000502:physiology; D001921:Brain / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission