title: [Role of cyclic adenosine-3',5'-monophosphate in the regulation of histidase in the skin in the process of ontogeny].
abstract: In rat skin the histidase activity was observed 2--3 days before delivery; it was increased at the first days of postnatal development, achieving a maximal level at the 5th day and then it was decreased (within 2--3 weeks of postnatal development) to the level activity, which was found in adult animals. Concentration of urocaninic acid in skin correlated with the histidase activity. Content of urocaninic acid in skin and the histidase activity were altered under effect of administration of cylic-3',5'-AMP, dibutyryl cyclic-3',5'-AMP, glucagon, sodium fluoride, theophylline, actinomycin D and cycloheximide.
mesh_terms: D000367:Age Factors; D000642:Ammonia-Lyases / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D000242:Cyclic AMP / Q000502:physiology*; D003609:Dactinomycin / Q000494:pharmacology; D004622:Embryo, Mammalian / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006638:Histidine Ammonia-Lyase / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000201:enzymology*; D012965:Sodium Chloride / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D014560:Urocanic Acid / Q000096:biosynthesis
chemical_list: D003609:Dactinomycin; D012965:Sodium Chloride; D012969:Sodium Fluoride; D005934:Glucagon; D013806:Theophylline; D000242:Cyclic AMP; D000642:Ammonia-Lyases; D006638:Histidine Ammonia-Lyase; D014560:Urocanic Acid
vernacular_title: Rol' tsiklicheskogo adenozin-3',5'-monofosfata v reguliatsii gistidazy v kozhe v protsesse ontogeneza