title: [Antiviral activity of tyrothricin against Sendai virus in suspension tests (author's transl)].
abstract: In suspension tests it could be found, that tyrothricin, isolated from bacteria, possesses an anti-infectious activity against Sendai virus. Concentrations of 10(2) to 10(3) ID50-units of Sendai virus were incubated with 0.5 and/or 1.0 mg tyrothricin per 5 ml for 30 minutes at 37 degrees C (pH 7.5). These mixtures were tested in embryonated eggs and showed a marked decrease of viral infectivity. Tween 80 added after the incubation period leads to an incomplete reactivation of the virus infectivity. According to these results and further preliminary studies on herpes simplex virus we suppose a virustatic effect of tyrothricin also in the case of other lipophilic viruses.
mesh_terms: D000998:Antiviral Agents; D002594:Cetylpyridinium / Q000494:pharmacology; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects*; D011136:Polysorbates / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D014449:Tyrothricin / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011136:Polysorbates; D014449:Tyrothricin; D002594:Cetylpyridinium
vernacular_title: Die antivirale Wirkung von Tyrothricin im Suspensionsversuch am Beispiel des Sendai-Virus.