title: Laryngeal carcinoma associated with multiple additional primary tumors. Immunologic studies.
abstract: Four malignant tumors and one benign in a 76-year-old man appeared. Three of the neoplasms were in the respiratory system, and one was a bladder carcinoma; all were linked to heavy smoking habits. The patient underwent immunologic investigations consisting of in vivo testing for cutaneous reactivity, in vitro lymphocyte blastogenesis studies, T- and B-cell level studies, and serum immunoglobulin level studies. The studies have demonstrated anergy to recall antigens, decreased lymphocyte responses to phytohemagglutinin, and low levels of peripheral T-lymphocytes. The serum immunoglobulins were at the upper limit of the normal. The relationship between the patient's immunologic status and the occurrence of multiple primary neoplasms is discussed.
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000276:immunology; D000235:Adenolymphoma / Q000276:immunology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D002295:Carcinoma, Transitional Cell / Q000276:immunology; D006258:Head and Neck Neoplasms / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007822:Laryngeal Neoplasms / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000276:immunology*; D010307:Parotid Neoplasms / Q000276:immunology; D012907:Smoking / Q000150:complications*; D013601:T-Lymphocytes / Q000276:immunology; D001749:Urinary Bladder Neoplasms / Q000276:immunology