Effects of opiates on cAMP in homogenates and slices of rat striata.
In slices of rat striata, incubated in a depolarizing medium (53 mM K+), morphine decreased by concentration of cAMP even in concentrations as low as 0.5 micron. This effect was inhibited by naloxone. Levorphanol, but not dextrorphan, induced a similar effect as morphine. In tissue, homogenized in a hypotonic medium, morphine (5-50 micron) also slightly decreased the concentration of cAMP, which was antagonized by naloxone. Neigher slices nor homogenates of morphine-withdrawn rats showed any alteration in the concentration of cAMP.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D003917:Dextrorphan / Q000494:pharmacology*; D007981:Levorphanol / Q000494:pharmacology*; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats
D009019:Morphinans; D003917:Dextrorphan; D007981:Levorphanol; D009270:Naloxone; D009020:Morphine; D000242:Cyclic AMP