Studies of hydrolytic enzymes and isoenzymes of normal and neoplastic childhood renal tissues and their tissue cultured cells.
The hydrolases of acid and alkaline phosphatase and non-specific esterases were investigated by histochemical and electrophoretic techniques in normal and neoplastic renal tissues and their cultured cells. A distinct tumour specific pattern of non-specific esterases was demonstrated in Wilms' tumour. The reasons for the quantitative differences found in the distribution of alkaline phosphatase in Wilms' tumour and their cultured cells are discussed.
D000135:Acid Phosphatase / Q000378:metabolism*; D000230:Adenocarcinoma / Q000201:enzymology; D000469:Alkaline Phosphatase / Q000378:metabolism*; D046508:Culture Techniques; D004950:Esterases / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D007680:Kidney Neoplasms / Q000201:enzymology*; D009396:Wilms Tumor / Q000201:enzymology
D007527:Isoenzymes; D004950:Esterases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase