[Digestive absorption, fixation and excretion of oral disulfiram in the rat].
Absorption, distribution and excretion of disulfiram and of one of its metabolites, diethyldithiocarbamate, were studied in rats orally treated with disulfiram (25 or 250 mg/kg). It was noted that this compound is absorbed in a proportion of 70-90 per cent of the administered dose but that diethyldithiocarbamate can appear already in the gut. After absorption, disulfiram and diethyldithiocarbamate impregnate specifically some tissues such as liver, kidney and muscle; blood and brain contain little or no disulfiram. The largest dose of disulfiram decreases fecal bolus and increases urinary volume favouring perhaps excretion of diethyldithiocarbamate.
D000284:Administration, Oral; D000818:Animals; D004221:Disulfiram / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D004050:Ditiocarb / Q000378:metabolism; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D013997:Time Factors
D004050:Ditiocarb; D004221:Disulfiram
Absorption digestive, fixation tissulaire et excrétion du disulfirame administré oralement chez le rat