DDC-induced retrograde amnesias prevented by injections of dl-DOPS.
Injection of a dopamine beta-hydroxylate inhibitor, diethyldithiocarbamate (DDC) in rats 30 min prior to training of a step-down passive avoidance task impaired performance of the task 24 hr later. Similarly, injection of DDC 30 min prior to testing blocked retrieval of a passive avoidance habit trained in normal rats the previous day. Injection of a direct norepinephrine (NE) precursor, dl-thero 3,4-dihydroxyphenylserine (DOPS) 60 min before DDC prevented both amnesias. These data support the hypothesis that reduced levels of NE are responsible for DDC-induced amnesias.
D000648:Amnesia, Retrograde / Q000139:chemically induced; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004050:Ditiocarb / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015103:Droxidopa / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D012694:Serine / Q000031:analogs & derivatives*; D013859:Thiocarbamates / Q000037:antagonists & inhibitors*; D013997:Time Factors
D013859:Thiocarbamates; D012694:Serine; D004050:Ditiocarb; D015103:Droxidopa