[Results of animal experiments concerning the carcinogenic effect of fibrous dusts and their interpretation with regard to the carcinogenesis in humans (author's transl)].
After reviewing the hypotheses about the pathogenesis of asbestos-induced malignant tumours we report about experimental data on animals. A high incidence of tumours (most of them mesotheliomas) was induced in rats by intraperitoneal injection of fibrous dusts (chrysotile, palygorscite, crocidolite, glass fibres, nemalite). Treatment with 8 types of granular dusts led though applicating a high dosage (50--100 mg) to neoplasms in only a small percentage of animals. After intraperitoneal application of 2 mg of chrysotile, crocidolite or glass fibres a tumour incidence in a range from 16% to 38% was observed and fibrous reaction was slight. 100 mg of milled chrysotile with relative short fibres (99.8% less than 5 mum, 99.5% less than 3 mum) caused no asbestosis, nevertheless tumours developed in 32% of the rats. Intraperitoneal injection of fibrous dusts also induced mesotheliomas in mice, however not in Syrian hamsters and guinea pigs. Our results point out that the fibrous shape of asbestos dust causes its carcinogenic effect and that furthermore other fibrous dusts can also lead to tumours. Prerequisites are an adequate measure of the fibres and their constancy in the tissue. For these two parameters no exact dates exist. It is estimated that a fibre with a diameter less than 1 mum and a length less than 3 mum exert a cancerogenic effect. Furthermore, a sequence of other factors has an importance for the dose-effect relationship of fibrous dusts. Material of the fibres plays a role in so far it defines the effect producing amount of fibres. The relevance of the results of animal experiments to man is discussed especially with regard to the cancerogenic effect of glass fibres.
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D006224:Cricetinae; D004391:Dust; D005898:Glass; D006168:Guinea Pigs; D006801:Humans; D008276:Magnesium Hydroxide / Q000633:toxicity; D008654:Mesothelioma / Q000139:chemically induced / Q000473:pathology; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced* / Q000473:pathology; D012824:Silicic Acid / Q000633:toxicity*; D012822:Silicon Dioxide / Q000633:toxicity*
D004391:Dust; D001194:Asbestos; D012824:Silicic Acid; D012822:Silicon Dioxide; D008276:Magnesium Hydroxide
Ergebnisse aus Tierversuchen zur kanzerogenen Wirkung faserförmiger Stäube und ihre Deutung im Hinblick auf die Tumorentstehung beim Menschen