[Dissociation of results obtained with an immunofluorescence technique by using anti-ACTH antibodies in three cases of pituitary "chromophobe" adenoma without hypercorticism; ultrastructural study (author's transl)].
Morphological studies of 3 pituitary "chromophobe" adenoma in patients without hypercorticism show positive immunofluorescenct cells with anti alpha, 17-39 ACTH antibody which are not revealed with anti beta, 1-24 ACTH antibody. These cells observed at the ultrastructural level contain secretory granules of 1,000 to 1,500 A in diameter. The existence in these cells of a substance having an immunological relationship with ACTH without biological activity is discussed.
D000238:Adenoma, Chromophobe / Q000276:immunology* / Q000648:ultrastructure; D000324:Adrenocorticotropic Hormone / Q000276:immunology*; D000906:Antibodies; D006801:Humans; D010911:Pituitary Neoplasms / Q000276:immunology* / Q000648:ultrastructure
D000906:Antibodies; D000324:Adrenocorticotropic Hormone
Dissociation des résultants obtenus en immunofluorescence avec des antisérums anti-ACTH dans trois cas d'adénomes "chromophobe" sans hypercorticisme. Etude ultrastructurale