The metabolism of 17beta-estradiol-3-glucosiduronate and estrone-3-glucosiduronate in the rabbit.
[6, 7-3H]-17beta-Estradiol-3-glucosiduronate, [6, 7-3H]-estrone-3-glucosiduronate or [6, 7-3H]-estrone was administered intravenously into the rabbit, and analysis and identification of the urinary metabolites were carried out. In either case, the major urinary metabolite was found to be a diconjugate. The sequential enzymic hydrolysis indicated that this diconjugate was glucosiduronate-N-acetyglucosaminide of 17alpha-estradiol. From these results, the conversion of the estrogen glucosiduronate into a diconjugate was thought a rather universal phenomenon in the rabbit.
D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism; D004966:Estrogens, Conjugated (USP) / Q000378:metabolism*; D004970:Estrone / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D011817:Rabbits / Q000378:metabolism*
D004966:Estrogens, Conjugated (USP); D005965:Glucuronates; C015856:estrone-3-glucuronide; D004970:Estrone; D004958:Estradiol