[Cytotoxicity of human T-lymphocytes sensitized by Epstein-Barr virus. Role of HLA antigens at the surface of target cells infected by the virus].
Peripheral T-lymphocytes from patients with infectious mononucleosis are cytotoxic towards target cells from Epstein-Barr virus-genome carrying human lumphoblastoid lines. Thus, these T-cells appear to be sensitized to viral coded determinants. Daudi cells, that carry EBV-genome, but lack HLA antigens are resistant to specific cytolysis in this model. These results suggest direct HLA involvement in the target structure recognized by birus-sensitized cytolytic T-lymphocytes in human.
D000937:Antigen-Antibody Reactions; D003601:Cytotoxicity Tests, Immunologic; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006649:Histocompatibility Antigens; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens
Cytotoxicité des lymphocytes T humains sensibilisés par le virus d'Epstein-Barr. Rôle des antigènes HLA à la surface des cellules-cibles infectées par le virus.