title: [Adrenocortical adenoma in a 2 1/2 year old girl causing virilization and accelerated growth. Clinical and morphological results (author's transl)].
abstract: A 2 1/2 year old girl with virilization and advanced bone age was found to have a leftsided adrenocortical adenoma. The secretion of mainly androgens besides estrogens was not suppressible with dexamethasone. Plasma cortisol levels were not elevated but did not show any circadian rhythm. The tumor was localized by retroperitoneal instillation of gas, intravenous urography and tomography. After complete removal of the tumor the originally strongly elevated excretion of 17-ketosteroids sank back to normal, the acceleration of skeletal development slowed down. The right adrenal cortex was not atrophic, 2 1/2 years after the operation the child is well and without evidence of recurrent disease. Differential diagnosis as well as ultrastructor and histology of the tumor are discussed with reference to the literature.
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D000236:Adenoma / Q000175:diagnosis / Q000601:surgery / Q000648:ultrastructure; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000648:ultrastructure; D001846:Bone Development; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood
chemical_list: D015068:17-Ketosteroids; D006854:Hydrocortisone
vernacular_title: Virilisierendes Nebennierenrindenadenom bei einem 2 1/2 jährigen Mädchen. Klinisch-endokrinologische und morphologische Befunde