title: Alkaline phosphatase in Epstein-Barr viral nuclear antigen--positive cell lines.
abstract: The production and nature of alkaline phosphatase were studied in Epstein-Barr viral nuclear antigen-positive, surface membrane immunoglobulin negative-cell lines established from two patients, one with acute myeloid leukemia and one with acute lymphoblastic leukemia. The acute myeloid leukemia-derived cells contained myeloid alkaline phosphatase, while the acute lymphoblastic leukemia-derived cells contained lymphoid alkaline phosphatase. The presence of the myeloid-specific enzyme in a surface membrane immunoglobin--negative cell line suggests that the line is composed of myeloid precursor cells and that such cells may be susceptible to infection with Epstein-Barr virus.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000956:Antigens, Viral / Q000032:analysis; D002467:Cell Nucleus / Q000276:immunology; D002472:Cell Transformation, Viral; D004854:Herpesvirus 4, Human / Q000276:immunology; D007527:Isoenzymes / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000201:enzymology* / Q000382:microbiology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology* / Q000382:microbiology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
chemical_list: D000956:Antigens, Viral; D007527:Isoenzymes; D011947:Receptors, Antigen, B-Cell; D000469:Alkaline Phosphatase