Selective antagonism of frog cerebellar synaptic transmission by manganese and cobalt ions.
Parallel fiber-Purkinje cell synaptic transmission of the frog cerebellum can be selectively blocked by Mn2+ and Co2+. The interaction of these cations with Ca2+ indicates that they act, as has been found for other chemical synapses, at the presynaptic terminals where Ca2+ is required for release of neurotransmitters. Climbing fiber-Purkinje cell synaptic transmission was similarly blocked by Mg2+, Mn2+ and Co2+.
D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects*; D011894:Rana pipiens; D009435:Synaptic Transmission / Q000187:drug effects*
D003035:Cobalt; D008345:Manganese; D008274:Magnesium