The lack of active bile acid transport in AS-30 D ascites hepatoma cells.
The uptake of cholic acid as well as taurocholic acid into AS-30 D ascites hepatoma cells showed linearity with respect to incubation concentrations. It has been suggested that these processes can be described as simple diffusion. In further experiments it could be shown that ascites hepatoma cells were unable to conjugate cholic acid. These results may have significance in the phalloidin action on hepatocytes.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001693:Biological Transport, Active; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002478:Cells, Cultured; D002793:Cholic Acids / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D051381:Rats; D013656:Taurocholic Acid / Q000378:metabolism; D014184:Transplantation, Homologous
D001647:Bile Acids and Salts; D002793:Cholic Acids; D013656:Taurocholic Acid