[Adriamycin cardiomyopathy in a child with Wilms tumor and liver metastases (author's transl)].
Nephrectomy with irradiation was performed in a 3;2 year old boy with Wilms tumor stage IV (livermetastases (liver metastases). Six months later a hemihepatectomy was performed on account of the liver metatases which persisted under a combined Actinomycin Vincristin therapy. A monotherapy with Adriamycin was instituted. The patient developed acute congestive heart failure. The patient developed acute congestive heart failure and showed typical EKG changes after a total dose of 700 mg/M2 of Adriamycin. In comparison to adults children reportedly tolerate somewhat higher total doses of Adriamycin. Therefore it is discussed, if in this case a limitation of liver function by hemihepatectomy and by irradiation has favored the appearance of the Adriamycin-induced cardiomyopathy.
D000208:Acute Disease; D002675:Child, Preschool; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000139:chemically induced*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D008297:Male; D009362:Neoplasm Metastasis; D009392:Nephrectomy; D009396:Wilms Tumor / Q000188:drug therapy / Q000601:surgery
D004317:Doxorubicin
Adriamycin--Kardiomyopathie bei einem Kind mit Wilmstumor und Lebermetastasen