Immunological studies with hamster cells transformed by cytomegalovirus and herpes simplex virus type 1.
Evidence is presented that cells transformed by CMV and HSV-1 express virus-associated antigens on the cell surface. The finding that hyper-immune antivirus sera block cellular immunity in vitro may explain why virus-immunized hosts have thus far not been found to reject isografts of these cells.
D000818:Animals; D000956:Antigens, Viral; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D003587:Cytomegalovirus / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014185:Transplantation, Isogeneic
D000956:Antigens, Viral