title: Type C RNA virus expression in systemic lupus erythematosus. New Zealand mouse model and human disease.
abstract: An antigen recognized by antisera produced against p30 (core) proteins of the four chief groups of mammalian type C viruses (murine, feline, RD-114 related to endogenous primate, and infectious primate group) is located in an immune-complex pattern in some renal glomeruli of human SLE patients with lupus proliferative glomerulonephritis but is not detected in normal or pathological control human kidneys. This antigen cross-reacts with p30 interspecies determinants shared by the four chief virus groups and cross-reacts with a partially purified antigen extracted from human SLE spleen. The human SLE spleen antigen cross-reacts with p30 group antigen of RD-114 virus but not of feline or murine viruses. Some host immunoglobulins eluted from a human SLE kidney by acid-buffer show antibody-like activity against p30 group antigen of RD-114 virus but not of simian, feline, or murine viruses.
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D003429:Cross Reactions; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D051379:Mice; D008814:Mice, Inbred NZB; D012328:RNA Viruses / Q000302:isolation & purification*; D012190:Retroviridae / Q000302:isolation & purification*; D013154:Spleen / Q000276:immunology; D014020:Tissue Extracts
chemical_list: D000956:Antigens, Viral; D014020:Tissue Extracts