title: Differential neurooncogenicity of strains of JC virus, a human polyoma virus, in newborn Syrian hamsters.
abstract: The neurooncogenicity recently isolated strains of the human polyoma virus, JC virus, was determined by intracerebral inoculation of newborn Syrian golden hamsters. All three strains produced malignant brain tumors in a majority of inoculated animals during a 6.5-month observation period. The results obtained with the MAD-2 strain, 19 of 20 animals with cerebellar medulloblastomas and 0 of 20 animals with pineal gland tumors, were quite similar to those observed previously with the prototypic strain of JC virus, MAD-1. Inoculation of the MAD-4 strain, however, resulted in 10 of 22 animals with pineal gland tumors and only 10 of 22 animals with tumors in the cerebellum. The MAD-3 strain was neurooncogenic, but too few animals lived to be weaned to provide significant additional information. The basis for the apparent predilection of the MAD-4 strain for the pineal gland is unknown. Two hamsters in the experiment developed extracranial neuroblastomas.
mesh_terms: D000008:Abdominal Neoplasms / Q000209:etiology; D000818:Animals; D000831:Animals, Newborn; D001932:Brain Neoplasms / Q000209:etiology*; D002528:Cerebellar Neoplasms / Q000209:etiology; D006224:Cricetinae; D008527:Medulloblastoma / Q000209:etiology; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D009447:Neuroblastoma / Q000209:etiology; D010871:Pinealoma / Q000209:etiology; D011120:Polyomavirus / Q000472:pathogenicity*; D013045:Species Specificity; D014412:Tumor Virus Infections