Lead potentiation of endotoxin lethality in rats: lack of effect of kininase inhibition.
Although lead and SQ20881 are potent in vitro inhibitors of kininase II activity, SQ20881 does not alter the sensitivity of rats to endotoxin. These results indicate that marked changes in plasma kininase activity do not contribute to endotoxin morbidity and that kininase inhibition is not the mechanism whereby lead ions sensitize rats to endotoxin.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D004357:Drug Synergism; D004731:Endotoxins / Q000633:toxicity*; D007854:Lead / Q000494:pharmacology*; D008168:Lung / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D051381:Rats; D013722:Teprotide / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D004731:Endotoxins; D007854:Lead; D013722:Teprotide; D007703:Peptidyl-Dipeptidase A