title: Seroepidemiological studies of human papilloma virus (HPV-1) infections.
abstract: At least two groups of human papilloma viruses can be distinguished serologically: on the one hand HPV 1-3, which are closely related but differ in the restriction enzyme pattern of their DNA, and on the other hand HPV-4. The age distributions of patients with warts induced by HPV 1-3 or by HPV-4, respectively, differ markedly. HPV 1-3 predominates between 5 and 15 years of age, whereas HPV-4 could be isolated more often between the ages of 20-25 years. The large number of HPV-1-3-induced warts in children is paralleled by a high percentage of HPV-1 antibody-positive sera in the same age group (about 50%). With increasing age the percentage of HPV-1 antibody-positive sera decline gradually. This pattern of seroreactivity was compared to that of patients with various papillomas and with several malignant tumors. There is no evidence to suggest a link between HPV 1-3 and condylomata acuminata, laryngeal papillomas or any of the malignant tumors tested.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003218:Condylomata Acuminata / Q000382:microbiology; D005860:Germany, West; D006801:Humans; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008722:Methods; D008875:Middle Aged; D009369:Neoplasms / Q000382:microbiology; D027383:Papillomaviridae; D011863:Radioimmunoassay; D012703:Serotyping; D014412:Tumor Virus Infections / Q000453:epidemiology*; D014860:Warts / Q000382:microbiology*
chemical_list: D000914:Antibodies, Viral; D007457:Iodine Radioisotopes