title: Adrenocortical function in aging exercise-trained rats.
abstract: Plasma corticosterone concentrations and in vitro adrenal secretion of corticosterone were determined in exercise-trained rats. Rats, 100, 200, and 300 days of age, were trained for a 10-wk period by treadmill running. Following the training program, rats were subjected to an acute bout of swimming. Acute swimming elevated plasma corticosterone concentrations in all age groups. At 170 days of age, the plasma corticosterone concentration following swimming was higher in exercise-trained rats than in controls. The opposite was true of acutely swum rats at 270 and 370 days of age. Acute swimming elevated the in vitro adrenal gland response to adrenocorticotropic hormone stimulation in control rats at all ages and in trained rats at 170 days of age. The in vivo relationship of epinephrine and the pituitary adrenal system is suggested as a mechanism which could have caused this response. The relationship of secretion rates to plasma corticosterone concentrations indicated that extra-adrenal mechanisms, such as decreased turnover, were also responsible for the elevated plasma corticosterone levels observed in response to acute swimming.
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000311:Adrenal Glands / Q000032:analysis; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000375:Aging; D000818:Animals; D001835:Body Weight; D003345:Corticosterone / Q000097:blood*; D005938:Glucocorticoids / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009929:Organ Size; D010807:Physical Endurance; D005082:Physical Exertion; D051381:Rats
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone