Leukemogenic activity of thymotropic, ecotropic, and xenotropic radiation leukemia virus isolates.
Thymotropic, ecotropic, and xenotropic oncoviruses were isolated from the C57BL/6 mouse radiation leukemia system and were propagated in culture. The purified viruses were inoculated singly and in various combinations into groups of mice, and leukemia incidence was determined. Only the thymotropic virus was leukemogenic in vivo.
D000818:Animals; D009052:Leukemia Virus, Murine / Q000254:growth & development / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000209:etiology / Q000382:microbiology*; D007953:Leukemia, Radiation-Induced / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000382:microbiology; D014779:Virus Replication