Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.
Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D007527:Isoenzymes / Q000096:biosynthesis; D009052:Leukemia Virus, Murine / Q000254:growth & development*; D051379:Mice; D008815:Mice, Inbred Strains; D010734:Phosphogluconate Dehydrogenase / Q000096:biosynthesis; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
D007527:Isoenzymes; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase