Design of analogs of purine nucleosides with specifically altered activities as substrates for nucleoside- metabolizing enzymes.
D000243:Adenosine Deaminase / Q000378:metabolism; D000970:Antineoplastic Agents; D010770:Phosphotransferases / Q000378:metabolism; D011684:Purine Nucleosides; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism; D013868:Thioinosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011684:Purine Nucleosides; D013868:Thioinosine; D011683:Purine-Nucleoside Phosphorylase; D010770:Phosphotransferases; D000243:Adenosine Deaminase; D014740:Vidarabine