Immunosupressive activity of the basic protein from tumor tissue.
The basic protein prepared from AH-130 ascites hepatoma cells was tested for its effect on the cell-mediated immune response of Donryu strain rats. The basic protein suppressed the response of peripheral and lymph node lymphocytes to phytohemagglutinin and lymphocyte trapping in the antigen-draining lymph node. These results indicated that the basic protein from tumor tissue possibly had an immunosuppressive activity and affected inadequately the cell-mediated immune response as usually observed in tumor-bearing hosts.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000032:analysis; D002374:Catalase / Q000378:metabolism; D003864:Depression, Chemical; D005260:Female; D007165:Immunosuppression Therapy; D037102:Lectins / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms; D008214:Lymphocytes / Q000276:immunology; D009363:Neoplasm Proteins / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000032:analysis; D051381:Rats
D037102:Lectins; D009363:Neoplasm Proteins; D002374:Catalase