Electronmicroscopic identification of type C particles in cultured murine neuroblastoma.
Monolayer of murine neuroblastoma were treated with dexamethasone and examined by electronmicroscopy. Most of the treated cells were morphologically differentiated and exhibited type C virus particles which were budding from the cell surface. This in vitro system may be of great value for exploring the oncogenic potential of the virus, and its possible role in cell differentiation.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003907:Dexamethasone / Q000494:pharmacology; D051379:Mice; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000648:ultrastructure; D009447:Neuroblastoma / Q000648:ultrastructure*; D012190:Retroviridae / Q000648:ultrastructure*; D014771:Virion / Q000648:ultrastructure; D014779:Virus Replication / Q000187:drug effects
D003907:Dexamethasone