Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.
The phosphonacetic acid (PAA)-susceptible deoxyribonucleic acid (DNA) polymerase of herpes simplex virus type 1 was partially purified and isolated in sucrose gradients and on double-strand DNA cellulose columns. The DNA polymerase isolated from cells infected with the PAA-resistant mutant had the same molecular weight as the wild-type enzyme (140,000 to 149,000) but was consistently more resistant to PAA.
D004259:DNA-Directed DNA Polymerase / Q000032:analysis*; D009154:Mutation; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000494:pharmacology*; D018139:Simplexvirus / Q000201:enzymology* / Q000235:genetics
D009943:Organophosphorus Compounds; D004259:DNA-Directed DNA Polymerase; D010746:Phosphonoacetic Acid