The effect of arginine deprivation on DNA, thymidine kinase and RNA polymerase synthesis in simian virus 40-infected monkey kidney cells.
In arginine-deprived cells infected with simian virus 40 (SV40), both viral DNA and viral structural proteins were synthesized but infectious virus was not produced. The syntheses of cellular DNA, thymidine kinase and DNA polymerase were induced in virus-infected cells deprived of arginine but the maximum rate of synthesis of these enzymes occurred much later than that in infected cells incubated in the presence of arginine.
D001120:Arginine / Q000378:metabolism*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004247:DNA / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis*; D013539:Simian virus 40 / Q000254:growth & development* / Q000378:metabolism; D013937:Thymidine Kinase / Q000096:biosynthesis*
D004279:DNA, Viral; D004247:DNA; D001120:Arginine; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase