Lymphocyte subpopulations in blood and cerebrospinal fluid from patients with acute Guillain-Barré syndrome.
The numbers of T and B lymphocytes were determined in blood and cerebrospinal fluid (CSF) from 25 patients with acute Guillain-Barré syndrome and from 30 controls. The relative and absolute number of T lymphocytes in blood was decreased in the patient group (mean 48 +/- 2% and 947 +/- 71/mm3 compared to 66 +/- 2% and 1,381 +/- 93/mm3 in controls). Correspondingly, the number of B lymphocytes was increased (mean 37 +/- 2% and 758 +/- 75/mm3 compared to 25 +/- 2% and 580 +/- 45/mm3 in controls). In the CSF the number of T lymphocytes was increased (85.0 +/- 2.2% compared to 76.9 +/- 2.4% in controls).
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000032:analysis; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D011129:Polyradiculoneuropathy / Q000097:blood / Q000134:cerebrospinal fluid; D011128:Polyradiculopathy / Q000378:metabolism*; D013601:T-Lymphocytes / Q000032:analysis