Opposite effect of PGE2 on cAMP levels in human adrenal medulla and pheochromocytoma.
PGE2 (10(-7) M) caused increased cAMP accumlation in 5 pheochromocytomas, while in 3 human adrenal medullae PGE2 caused a significant decrease of cAMP level on incubating slices in vitro. This finding is discussed in relation to the opposite effect of PGE2 on catecholamine release from human medulla and pheochromocytoma slices in vitro.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D010673:Pheochromocytoma / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D000242:Cyclic AMP