[Effect of antikinin agents on the course of experimental myocarditis].
The therapeutic action of 5 preparations: specific antikinin substances -- anginin and contrical, and nonspecific -- epsilon-aminocapronic acid, aspirin and indometacine, was tested in 71 rabbits with allergic myocarditis. It has been concluded that in the allergic distruction of the myocardium plasma kinins, which are formed and accumulated in large quantities, take part in the pathogenesis of the disease serving as mediators of the tissue distruction, therefore specific antagonists of kinins and inhibitors of the kinin system should be included as pathogenetic agents into the complex of allergic myocarditis treatment.
D000614:Aminocaproates / Q000627:therapeutic use; D000818:Animals; D007611:Aprotinin; D001241:Aspirin / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D007213:Indomethacin / Q000627:therapeutic use; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D001121:Lysine Carboxypeptidase / Q000097:blood; D009205:Myocarditis / Q000097:blood / Q000188:drug therapy*; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011727:Pyridinolcarbamate / Q000627:therapeutic use; D011817:Rabbits
D000614:Aminocaproates; D007705:Kinins; D011727:Pyridinolcarbamate; D007611:Aprotinin; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D007610:Kallikreins; D001241:Aspirin; D007213:Indomethacin
Deĭstvie antikininovykh veshchestv na techenie eksperimental'nogo miokardita