Inactivation of equine infectious anemia virus by chemical disinfectants.
Twelve chemicals and commercial disinfectants were tested for inactivation of equine infectious anemia virus. In the presence of 10% bovine serum, all chemicals inactivated 4 log10 (based on 0.1 ml) of the virus within 5 minutes at 23 C. A reduction of at least 4 log10 was observed when the virus was exposed for 1 minute to substituted phenolic disinfectants (3 commercial preparations and sodium orthophenylphenate), halogen derivatives (iodophor and sodium hypochlorite), chlorhexidine, and 70% ethanol. Sodium hydroxide (5%), 2% formalin, and 2% glutaraldehyde were slower to inactivate the virus, but achieved 4 log10 reduction in titer by 5 minutes' contact time. The susceptibility of the equine infectious anemia virus to chemical disinfectants is similar to that of other enveloped viruses.
D002478:Cells, Cultured; D002710:Chlorhexidine / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D005976:Glutaral / Q000494:pharmacology; D004860:Infectious Anemia Virus, Equine / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D007466:Iodophors / Q000494:pharmacology; D012973:Sodium Hypochlorite / Q000494:pharmacology
D004202:Disinfectants; D007466:Iodophors; D012973:Sodium Hypochlorite; D002710:Chlorhexidine; D005976:Glutaral