Comparison of the development of resistant strains of Type 1 herpes simplex virus to in vitro antiviral activity of 5-iodo-2'-deoxyuridine or ribavirin.
Exposure of HSV/1 to low concentrations of ribavirin during 4--5 passages does not produce ribavirin-resistant virus. IDU resistance was developed by HSV/1 while it was being passed simultaneously. This resistance was seen to develop in both KB and Vero cells. The IDU-resistant virus is also resistant to ribavirin in KB cells.
D004352:Drug Resistance, Microbial; D007065:Idoxuridine / Q000494:pharmacology*; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D013997:Time Factors; D014776:Virus Cultivation
D012263:Ribonucleosides; D012254:Ribavirin; D007065:Idoxuridine