[Effect of etimizol on super-slow electrical oscillations and the concentration of noradrenaline in nuclei of the rabbit hypothalamus].
Following intramuscular administration of a 2.5 mg/kg dose of ethymisol to curarized rabbits with implanted gold electrodes in the anterior group of hypothalamic nuclei, a correlation was revelaed between the amplitude of superslow electrical oscillations of 0 to 1 c/s and the noradrenaline content in the brain tissue. After ethymisol administration, the positive wave of the slow oscillation disappeared, while the adrenaline content in the hypothalamic area decreased from 0.93 mkg/g to 0.16 mkg/g of the tissue. By means of phentolamine and propranolol adrenoblockators the participation of alpha-and beta-receptors of the hypothalamus in the ethymisol effect has been proved.
D000818:Animals; D004594:Electrophysiology; D005042:Etimizol / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta
D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D005042:Etimizol; D009638:Norepinephrine
Vliianie étimizola na sverkhmedlennye élektricheskie kolebaniia i soderzhanie noradrenalina v iadrakh gipotalamusa krolika