The ocular anti-inflammatory action of imidazole.
Imidazole administered intraperitoneally to albino rabbits at a dose of 250 mg. per kilogram inhibited the rise of aqueous humor protein concentration by approximately 50 per cent 30 minutes after paracentesis. Systemic imidazole administered daily to albino rabbits injected with intravitreal Shigella endotoxin decreased the conjunctival and iris hyperemia and reduced the anterior chamber cell and flare and the haziness of the optical media. Systemically administered imidazole had no effect on the aqueous humor concentrations of c-AMP or c-GMP in the rabbit. In vitro studies of rabbit ciliary body-iris phosphodiesterase activity indicated no effect of imidazole at a  concentration of 10(-3) molar.
D000249:Adenosine Monophosphate / Q000032:analysis; D000818:Animals; D000893:Anti-Inflammatory Agents; D001082:Aqueous Humor / Q000187:drug effects; D003231:Conjunctivitis / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D004731:Endotoxins / Q000494:pharmacology; D005123:Eye / Q000187:drug effects*; D006150:Guanine Nucleotides / Q000032:analysis; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D010727:Phosphoric Diester Hydrolases / Q000032:analysis; D011817:Rabbits; D012760:Shigella; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy; D014822:Vitreous Body / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D004731:Endotoxins; D006150:Guanine Nucleotides; D007093:Imidazoles; D000249:Adenosine Monophosphate; D010727:Phosphoric Diester Hydrolases