[Some ways to eliminate the side effects of antibiotic therapy in experimental pneumonia].
Impairement in the process of tissue respiration at the subcellular level in growing animals with experimental pneumonia are described. Under the conditions of antibiotic therapy such impairements aggravated. A combined use of antibiotics with succinic and glutamic acids resulted in improvement of the tissue respiration and acceleration of reparation. Possible mechanisms of this phenomenon are discussed.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects; D005971:Glutamates / Q000008:administration & dosage; D009980:Influenza A virus; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000378:metabolism; D011024:Pneumonia, Viral / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D012310:Ristocetin / Q000008:administration & dosage; D013386:Succinates / Q000008:administration & dosage; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005971:Glutamates; D013386:Succinates; D009243:NAD; D012310:Ristocetin
Nekotorye puti ustraneniia pobochnogo deĭstviia antibiotikoterapii pri éksperimental'noi pnevmonii