Vascular alpha adrenotropic responses of the isolated rabbit kidney at 15 degrees C.
Rabbit kidneys were isolated and perfused with a balanced salt solution at 15 degrees C. The effects of norepinephrine (NOR) and phentolamine (P) were tested after fastly or slowly induced cooling. Vascular alpha receptor effects were enhanced by a slow cooling rate (0.6 degrees C/min), but blocked or impaired by a faster cooling rate (6 degrees C/min). Kidney function was severely impaired at this temperature as it would be expected.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D003080:Cold Temperature; D005260:Female; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014666:Vasomotor System / Q000187:drug effects*
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D000804:Angiotensin II; D012964:Sodium; D011188:Potassium; D009638:Norepinephrine; D010646:Phentolamine