Studies on the hydrolysis of bradykinin by angiotensin-converting enzyme (kininase II).
Arg-Pro-Pro-Gly-Phe, the N-terminal pentapeptide of bradykinin, is not an inhibitor of angiotensin-converting enzyme and is not hydrolyzed by the enzyme. Arg-Pro-Pro, the N-terminal tripeptide is a relatively potent (IC50 = 2.3 X 10(6) M) inhibitor but its higher homolog. Gly-Arg-Met-Lys-Arg-Pro-Pro is not an inhibitor of angiotensin-converting enzyme.
D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin; D006868:Hydrolysis; D009842:Oligopeptides / Q000494:pharmacology; D007703:Peptidyl-Dipeptidase A; D013722:Teprotide / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D013722:Teprotide; D007703:Peptidyl-Dipeptidase A; D001920:Bradykinin