title: [Study of foot-and-mouth disease virus inhibitors in cell cultures and experimental animals].
abstract: Studied was the inhibiting action of some synthetic agents conditionally denoted No. 3 (benzamidazol), No. 76, and No. 78 (imidazolins) on the reproduction of the foot-and-mouth disease virus in cell cultures, newborn mice and guinea pigs. It was irrefutably demonstrated that all three agents produce an inhibiting effect on the virus. This effect was enhanced by the combined use of these inhibitors. It was found that best effect on the virus' replication produced the combination of agent No. 3 and some of the other two inhibitors. Discussed is the mechanism of action of these compounds.
mesh_terms: D000327:Adsorption; D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000494:pharmacology*; D005537:Aphthovirus / Q000187:drug effects*; D001562:Benzimidazoles / Q000494:pharmacology; D002478:Cells, Cultured; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005536:Foot-and-Mouth Disease / Q000188:drug therapy; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology; D051379:Mice; D010919:Placebos; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D007093:Imidazoles; D010919:Placebos
vernacular_title: Prouchvane na niakoi inkhibitori na shapniia virus v kletuchni kulturi i opitni zhivotni