Alterations in the surface properties of cells responsive to nerve growth factor.
An initial effect of nerve growth factor on a responsive nerve cell line is to increase intracellular cyclic AMP, which in turn leads to a mobilisation of calcium ions. These events are correlated with structural changes in the plasma membrane, increased cell-substratum adhesion, and neurite outgrowth.
D002118:Calcium / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects*; D002449:Cell Aggregation / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D037102:Lectins / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology*; D011188:Potassium / Q000494:pharmacology; D013499:Surface Properties; D014747:Vinblastine / Q000494:pharmacology
D037102:Lectins; D009414:Nerve Growth Factors; D014747:Vinblastine; D000242:Cyclic AMP; D011188:Potassium; D002118:Calcium