Urinary cyclic AMP in hyperthyroidism.
Urinary cyclic AMP was studied in 22 female and in 6 male hyperthyroid normocalcemic patients and in 3 hyperthyroid hypercalcemic men. Cyclic AMP/creatinine ratios were elevated both in female (4.12 +/- 0.26 mumoles/gm creatinine) and male (3.92 +/- 0.41 mumoles/gm creatinine) hyperthyroid normocalcemic patients as compared with normal female and male controls (2.85 +/- 0.20 and 2.54 +/- 0.14 mumoles/gm creatinine, respectively). However, there was no difference in the 24-hour urinary cyclic AMP excretion of both hyperthyroid and normal subjects. The hyperthyroid hypercalcemic men excreted less (2.47 +/- 0.19) mumoles/24 hr) cyclic AMP/24 hr than the normal male controls. In the thirteen female patients, studied when euthyroid, the cyclic AMP/creatinine ratio was normalised.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000652:urine; D000242:Cyclic AMP / Q000652:urine*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000652:urine*; D006980:Hyperthyroidism / Q000150:complications / Q000652:urine*; D008297:Male; D008875:Middle Aged
D003404:Creatinine; D000242:Cyclic AMP