[Bone tissue collagen and vitamin D in chronic kidney insufficiency in rats].
Chronic kidney insufficiency, caused by subtotal nephrectomy, did not lead to distinct alterations in hydroxyproline concentration in blood and to its excretion in rats within 1-1.5 months after the operation. Content of salt-soluble collagen was decreased in diaphyses of rat tubular bones in chronic kidney insufficiency; in the epiphyses (with metaphyses) content of the collagen fraction was increased, but the concentration of non-soluble collagen was unaltered. Decrease in content of salt-soluble collagen in diaphyses in chronic kidney insufficiency was similar to that in experimental vitamin D deficiency. The decrease might be due to impairment in formation of the active form of vitamin D-1,25-dihydroxycholecalciferol. Other pathogenetic factors (effect of uremic toxins and stress) were apparently of primary importance for development of impairments of collagen metabolism in epiphyses. Dihydrotachysterol, the structural analogue of 1,25-dihydroxycholecalciferol, normalized the alterations in content of salt-soluble collagen in diaphyses and did not affect the impairments of collagen metabolism in epiphyses of rat bones in chronic kidney insufficiency.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D004838:Epiphyses / Q000378:metabolism; D006909:Hydroxyproline / Q000097:blood / Q000652:urine; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008297:Male; D010758:Phosphorus / Q000097:blood; D051381:Rats; D014807:Vitamin D / Q000378:metabolism*
D014807:Vitamin D; D002762:Cholecalciferol; D010758:Phosphorus; D003094:Collagen; D006909:Hydroxyproline; D002118:Calcium
Kollagen kostnoĭ tkani i vitamin D pri khronicheskoĭ pochechnoĭ nedostatochnosti u krys.