Correlation between articular cartilage collagenase activity and osteoarthritis.
Articular cartilage collagenase activity was determined for 28 sections obtained from twelve femoral heads. For each one square centimeter area, a section was graded by a histologic-histochemical grading system for the severity of the arthritis. Collagenase activity was found primarily in those areas of moderately severe disease, but not in mild or end stage arthritis.
D000368:Aged; D002358:Cartilage, Articular / Q000201:enzymology*; D005270:Femur Head; D006801:Humans; D003012:Microbial Collagenase / Q000378:metabolism*; D008875:Middle Aged; D010003:Osteoarthritis / Q000201:enzymology*; D014357:Trypsin / Q000494:pharmacology
D014357:Trypsin; D003012:Microbial Collagenase