Proteoglycans and collagenase in hypertrophic scar formation.
The collagen fibers of the nodules and whorl-like figures in hypertrophic scars are "coated" with proteoglycans, mainly chondroitin-4-sulfate. The latter was shown to prevent collagenase from breaking down collagen. This suggests that the presence of great amounts of chondroitin-4-sulfate in hypertrophic scars may contribute to the overabundance of collagen deposition which is characteristic of this abnormal healing process.
D002648:Child; D002675:Child, Preschool; D002809:Chondroitin Sulfates / Q000378:metabolism; D002921:Cicatrix / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D006801:Humans; D006984:Hypertrophy; D003012:Microbial Collagenase / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*
D011509:Proteoglycans; D002809:Chondroitin Sulfates; D003094:Collagen; D003012:Microbial Collagenase