Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test.
Seventeen cancer chemotherapeutic agents were tested for their ability to mutate Salmonella typhimurium tester strains in the Salmonella/microsome mutagenicity test. There was a high correlation between the mutagenicity and carcinogenicity of a given agent. Carcinogens positive in the test were Adriamycin, daunomycin, 1-propanol-3,3'-iminodimethanesulfonate, cyclophosphamide, isophosphamide, hycanthone, chlornaphazin, nitrogen mustard, uracil mustard, melphalan, and thio-tepa. Two carcinogesn, actinomycin D and bleomycin, were not detected as mutagens. The presumptive noncarcinogen, methotrexate, was negative in the test. Tilorone and 6-mercaptopurine, tentatively classified as noncarcinogens, were mutagenic. The carcinogenicity of cis-dichlorodiammineplatinum(II), which was positive in the test, has not been determined.
D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006826:Hycanthone / Q000494:pharmacology; D007069:Ifosfamide / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008466:Mechlorethamine / Q000494:pharmacology; D008558:Melphalan / Q000494:pharmacology; D015122:Mercaptopurine / Q000494:pharmacology; D008698:Mesylates / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology; D013994:Tilorone / Q000494:pharmacology; D014499:Uracil Mustard / Q000494:pharmacology
D000970:Antineoplastic Agents; D002273:Carcinogens; D008698:Mesylates; D009153:Mutagens; D009588:Nitrogen Mustard Compounds; D011437:Propylamines; D006826:Hycanthone; C010406:chlornaphazin; D008466:Mechlorethamine; D004317:Doxorubicin; D003520:Cyclophosphamide; D013852:Thiotepa; D015081:2-Naphthylamine; D015122:Mercaptopurine; D013994:Tilorone; D002945:Cisplatin; D008558:Melphalan; D007069:Ifosfamide; D014499:Uracil Mustard; D003630:Daunorubicin