Effects of human chorionic gonadotropin and N6,O2'-dibutyryladenosine 3' ,5'-monophosphate on phosphofructokinase activity in isolated rat testis.
Phosphofructokinase activity in rat testis is elevated by treatment in vitro with human chorionic godadotropin or N6,O2'-dibutyryladenosine 3' ,5'-monophosphate. Puromycin or actinomycin D suppresses the effect of the gonadotropin but does not affect the enzyme increase induced by the cyclic nucleotide. The possible cause for the divergent action of the two stimulatory agents are discussed.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D008297:Male; D010732:Phosphofructokinase-1 / Q000378:metabolism*; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000201:enzymology*
D006063:Chorionic Gonadotropin; D003609:Dactinomycin; D011691:Puromycin; D003994:Bucladesine; D010732:Phosphofructokinase-1