Latent herpes simplex virus infections in sensory ganglia of mice after topical treatment with adenine arabinoside and adenine arabinoside monophosphate.
Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred only a partial protection against the establishment of latent HSV infection in the spinal root ganglia of the treated animals. The immune response, as judged from levels of HSV-specific neutralizing serum antibody titers, was not impaired by the antiviral treatment.
D000287:Administration, Topical; D000818:Animals; D000906:Antibodies / Q000032:analysis; D002493:Central Nervous System Diseases / Q000517:prevention & control*; D005727:Ganglia, Spinal; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D009824:Ointments; D018139:Simplexvirus / Q000187:drug effects; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D014740:Vidarabine / Q000008:administration & dosage* / Q000627:therapeutic use
D000906:Antibodies; D009824:Ointments; D014740:Vidarabine