title: [Peptidyl prolyl hydroxylase activity in relation to the actual collagen biosynthesis in cotton pellet granuloma of guinea pig (author's transl)].
abstract: During the different stages of granuloma formation peptidyl prolyl hydroxylase activity and neutral salt soluble collagen were determined in the granuloma tissue. In parallel peptidyl prolyl hydroxylase activity, "collagen-like protein", and free hydroxyproline were measured in the serum of the same animals at correspondant time distances. A close correlation was found between the enzyme activity and the other parameters of collagen synthesis. These results confirm the conclusion that hydroxylation of polypeptide may be a rate limiting step in collagen biosynthesis. In addition the investigations revealed a close correlation between enzyme activity in the tissue and enzyme activity in the serum.
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D003368:Gossypium; D006099:Granuloma / Q000201:enzymology / Q000378:metabolism*; D006168:Guinea Pigs; D006909:Hydroxyproline / Q000097:blood; D011393:Procollagen-Proline Dioxygenase / Q000032:analysis* / Q000097:blood; D012871:Skin Diseases / Q000378:metabolism*
chemical_list: D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline
vernacular_title: Die Peptidylprolylhydroxylaseaktivität in Relation zur Kollagenbiosynthese in Wattegranulomen bei Meerschweinchen.