Immunotherapy of a guinea pig hepatoma with living BCG: a frozen liquid and a lyophilized preparation are equally active.
A freeze dried preparation of BCG with a low ratio of living to dead organisms (LV) was compared to a frozen liquid preparation with high viability (HV) for its ability to eradicate established dermal tumors and microscopic lymph node metastases in guinea pigs. The cure rate achieved by the intralesional injection of LV-BCG did not differ significantly from that of HV-bcg when similar numbers of viable organisms were injected.
D000818:Animals; D001500:BCG Vaccine / Q000302:isolation & purification* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000628:therapy; D005260:Female; D005612:Freeze Drying; D005615:Freezing; D006168:Guinea Pigs; D008113:Liver Neoplasms / Q000628:therapy; D008297:Male; D009374:Neoplasms, Experimental / Q000628:therapy; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000628:therapy*
D001500:BCG Vaccine