[Effect of apressin, obsidan, diprazine and their combination on the concentration of NAD and NADH2 in the liver and brain of hypoxic rats].
Apressin (2.5 mg/kg), obsidan (10 mg/kg), and diprazine (10mg/kg) caused an increase in the content of NAD + NAD.H2, without affecting their ratio, in the liver and brain of intact animals. These drugs, taken in the same doses, especially when used together, caused an increase in the NAD + NAD.H2 level; as to NAD/NAD.H2 ratio--it decreased in the state of hypoxia. The authors believe the antihypoxic action of apressin, obsidan, and diprazine to be connected with the rise in the total nicotinamide adenine denucleotide content and with increase of its oxidized form.
D000208:Acute Disease; D000818:Animals; D001923:Brain Chemistry; D004338:Drug Combinations; D005260:Female; D006830:Hydralazine / Q000008:administration & dosage / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy*; D008099:Liver / Q000032:analysis; D009243:NAD / Q000032:analysis*; D010084:Oxidation-Reduction; D011398:Promethazine / Q000008:administration & dosage / Q000627:therapeutic use*; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
D004338:Drug Combinations; D009243:NAD; D006830:Hydralazine; D011433:Propranolol; D011398:Promethazine
Vliianie apressina, obzidana, diprazina i ikh kombinatsii na soderzhanie na soderzhanie NAD i NADH2 v pecheni i mozge krys pri gipoksii.