Antiviral action and cellular toxicity of four thymidine analogues: 5-ethyl-,5-vinyl-, 5-propyl-, and 5-allyl-2'- deoxyuridine.
5-Ethyl-, 5-vinyl-, 5-propyl-, and 5-allyl-2'-deoxyuridine (dUrd) had antiviral activity against herpes simplex type 1 and type 2 grown in HeLa TK(-) cells, in the order 5-vinyl-dUrd, 5-ethyl-dUrd, 5-propyl-dUrd, 5-allyl-dUrd, but they were inactive against a TK(-) mutant of herpes simplex type 1. The antiviral activity of these compounds could be partially reversed by thymidine. Except for 5-vinyl-dUrd, they were not toxic to WI-38 and HeLa TK(-) cells at a concentration of 25 muM. All four analogues inhibited the growth of herpes simplex type 1-transformed HeLa TK(-) cells at a concentration of 1 muM.
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003857:Deoxyuridine