[Effect of anticholinesterase agents on the protein and RNA content in the cells of the supraoptic nucleus during sleep and its disorder].
In rats, administration of anticholinesterase drugs (both the penetrating blood-brain barrier armin and the nonpenetrating preparation Gd-42) prevented the decrease of protein content in the neurons and glia of the supraoptic nucleus, as well as of RNA content in the neurons which usually occurred in intact animals after 24-hr deprivation of the REM sleep by the Jouvet method (also with partial disturbance of the slow wave phase).
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009578:Nitrobenzenes / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000502:physiology; D013495:Supraoptic Nucleus / Q000378:metabolism*; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D009578:Nitrobenzenes; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D011506:Proteins; C002674:methylsulfomethylate; D012313:RNA
Vliianie antikholinésteraznykh agentov na soderzhanie belkov i RNK v kletkakh supraopticheskogo iadra pri sne i ego narushenii.