[Influence of chemical carcinogens on the physiological effects of adrenomimetics].
The experiments on isolated atria of rats and guinea pigs have shown that chemical hepatotropic carcinogens (diethylnitrosoamine and 2-acetyl aminofluorene) modify the physiological effects of adrenomimetics. A correlation between the authors' findings and the literature data on application of adrenergic drugs in carcinogenesis allows a suggestion to be made on the possibility of a principally new aspect in the mechanism of action of chemical carcinogens related to their effect on adrenoreceptors of target-organs.
D015073:2-Acetylaminofluorene / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D004052:Diethylnitrosamine / Q000494:pharmacology; D004347:Drug Interactions; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*
D002273:Carcinogens; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D004052:Diethylnitrosamine; D015073:2-Acetylaminofluorene; D007545:Isoproterenol; D009638:Norepinephrine
Vliianie khimicheskikh kantserogenov na fiziologicheskie éffekty adrenomimetikov.