Further immunological evidence for the presence of Fc receptors on the surface of HSV-infected cells.
By coupling passive hemadsorption (PHads) reaction with a complement-mediated cytotoxicity test (CT) it is possible to detect the presence on the surface of hamster embryo fibroblasts of Forssman antigens, hindering the demonstration by PHads of the receptors for the Fc-fragment of immunoglobulins (FcR), possibly induced by herpes simplex virus (HSV). These antigens are acetone- and formol-resistant, but they are destroyed by treatment with methanol or ethanol. However, CT with anti-sheep RBC serum performed in HSV-infected monkey kidney cells is always negative, which proves that the attachment of immunoglobulins to these cells occurs exclusively through their Fc-fragments.
D000818:Animals; D000956:Antigens, Viral; D001666:Binding Sites, Antibody; D002478:Cells, Cultured; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D006382:Hemadsorption; D007141:Immunoglobulin Fc Fragments; D066298:In Vitro Techniques; D018139:Simplexvirus / Q000276:immunology*; D014776:Virus Cultivation
D000956:Antigens, Viral; D007141:Immunoglobulin Fc Fragments