[Induction of antibodies to native DNA by components of Bordetella pertussis].
Administration of Bordetella pertussis and some of their components to mice induced an increase of DNA-binding activity of the sera revealed under ionic strength conditions of physiological saline, mostly on the 14th day. It was shown by the inhibition method that interaction between mouse sera and native DNA was specific. Maximum increase in the quantity of mouse sera proteins reacting with DNA under low ionic strength condition of physiological saline (0.05 M NaCl) is revealed on the 7th day. However, in administration of Bordetella pertussis and their cytoplasmic membrane the elevated DNA-binding proteins content persisted up to 14 days.
D000818:Animals; D000942:Antigens, Bacterial; D001323:Autoantibodies; D001886:Bordetella pertussis / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D008070:Lipopolysaccharides; D051379:Mice; D008810:Mice, Inbred C57BL
D000942:Antigens, Bacterial; D001323:Autoantibodies; D008070:Lipopolysaccharides; D004247:DNA
Induktsiia antitel k nativnoĭ DNK komponentami Bordetella pertussis.