title: Some properties of beta-toxin produced by Clostridium perfringens type C.
abstract: Purified beta-toxin from Clostridium perfringens type C was found to be a single polypeptide chain protein with a molecular weight of approximately 30,000. The toxin was heat labile, with 75% of its activity being inactivated by incubation at 50 degrees C for 5 min. Biological activity of the purified toxin was completely destroyed on exposure to trypsin for 30 min at 37 degrees C. The 50% lethal dose for mice was 1.87 microgram of purified toxin.
mesh_terms: D000818:Animals; D003016:Clostridium perfringens; D006358:Hot Temperature; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D014118:Toxins, Biological / Q000096:biosynthesis / Q000302:isolation & purification; D014357:Trypsin / Q000494:pharmacology
chemical_list: D014118:Toxins, Biological; D014357:Trypsin