[On 14C-nicotinate penetration into cellular and subcellular structures of animals following adrenalectomy and hormone administration].
The experiments on the Wistar line rats and mongrel dogs showed that gravitational overloading, surgical and chemical adrenalectomy, injections of certain hormones and actinomycin D affect essentially the permeability of blood cells and liver mitochondria to 14C nicotinic acid. An assumption is advanced that the transport of 14C nicotinic acid to biological structures occurs with participation of complex mechanisms, the function of which is regulated by hormones and is coupled with the processes of protein synthesis.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009539:Nicotinic Acids / Q000378:metabolism*; D010539:Permeability; D051381:Rats; D013045:Species Specificity
D009539:Nicotinic Acids; D003609:Dactinomycin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D004837:Epinephrine
O proniknovenii 14-C-nikotinata v kletochnye i subkletochnye struktury zhivotnykh posle adrenalektomii i vvedeniia rogmonov.