About the influence of halogenated pyrimidines on the in vivo-oncogenesis.
Reported are in vivo trials on Friend virus-leukemia (FVL), on methylcholanthren-induced fibrosarcomas of the mouse, and on amelanotic melanoma No. 3 of the Syrian hamster after treatment with halogenated pyrimidines, 5'-bromodeoxyuridine (BUDR) and 5'-iododeoxyuridine (IUDR) as to provoke genuine oncorna viruses. Till now, no prove exists that in tissue culture propagated C-type particles are really oncogenic. From the results demonstrated here the conclusion can be drawn that the chosen in vivo-conditions neither oncogens, possibly located in the cells, will be finished to complete oncogenic viruses, nor a spread and multiplication of dormant viruses will take place due to a provocation treatment of the hosts with halogenated pyrimidines. It seems, therefore, that the requirements to activate oncogens in vitro are absolutely different to those needed under in vivo conditions.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D006224:Cricetinae; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced; D005622:Friend murine leukemia virus; D007065:Idoxuridine / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000209:etiology; D008545:Melanoma / Q000209:etiology; D008748:Methylcholanthrene; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology*; D012190:Retroviridae; D012513:Sarcoma, Experimental / Q000139:chemically induced
D008748:Methylcholanthrene; D001973:Bromodeoxyuridine; D007065:Idoxuridine