Prevalence of non-T-cells in the replication of the N-tropic, type C virus of young AKR mice.
The XC infectious center assay was used to study the nature of the lymphoid cells producing N-tropic C-type viruses in preleukemic AKR mice. Viral production by thymic cell suspensions was very low and was possibly due to contaminating cells. Production at least 100-fold higher was found in spleen cells and was probably due to non-T-cells. The significance of these results is discussed briefly, including the possibility that the N-tropic XC syncitia-inducing type C virus of young AKR mice is not the leukemogenic agent.
D000406:AKR murine leukemia virus; D000818:Animals; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology*; D051379:Mice; D008806:Mice, Inbred AKR; D011289:Preleukemia / Q000382:microbiology*; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000382:microbiology; D013950:Thymus Gland / Q000382:microbiology; D014412:Tumor Virus Infections / Q000382:microbiology; D014779:Virus Replication