Specific antagonism of excitant amino acids in the isolated spinal cord of the neonatal rat.
The specificity of the neurodepressant actions of D-alpha-aminoadipate, alpha,epsilon-diaminopimelic acid, HA-966 (HAP) and Mg2+ has been investigated. On the isolated spinal cord of the neonatal rat, ventral root depolarizations produced by kainate, substance P, carbachol and noradrenaline were relatively unaffected by the same concentrations (0.25--1 mM) of the agents as those which reduced synaptic activity and ventral root depolarizations produced by N-methyl-D-aspartate (especially), L-aspartate and L-glutamate. The same or higher concentrations of the agents did not affect excitatory transmission in the isolated rat superior cervical ganglion. It is proposed that the agents specifically block synaptic transmission mediated by an excitatory amino acid.
D015074:2-Aminoadipic Acid / Q000494:pharmacology; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D003960:Diaminopimelic Acid / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology; D009046:Motor Neurons / Q000187:drug effects; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D000596:Amino Acids; D011760:Pyrrolidinones; D015074:2-Aminoadipic Acid; D003960:Diaminopimelic Acid; D008274:Magnesium