Genetic factors influencing endogenous type-C RNA viruses of mouse cells: control of viral polypeptide expression in the C57BL/10 strain.
Type-C viral polypeptides are expressed at very low levels in C57BL/10 liver and embryo cells as compared to cells of other mouse strains. The 12,000-mol. wt. polypeptide in C57BL/10 cells was purified and shown to possess type-specific antigenic determinants indistinguishable from those of a previously described class of endogenous virus. The very low levels of endogenous virus-specific RNA in cells of C57BL/10 as compared to other strains suggests control of this endogenous virus at the level of transcription. Analysis of viral antigen expression F1 hybrids of C57BL/10 with strains characterized by intermediate and high levels of viral antigen expression indicates that the restriction of this endogenous virus by C57BL/10 cells is not due to simple dominance by a repressor of virus expression.
D000818:Animals; D000956:Antigens, Viral; D002478:Cells, Cultured / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D012367:RNA, Viral / Q000378:metabolism*; D012190:Retroviridae / Q000254:growth & development / Q000276:immunology; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000096:biosynthesis*
D000956:Antigens, Viral; D012367:RNA, Viral; D014764:Viral Proteins