Hypolipidemic activity of in vitro inhibitors of hepatic and intestinal sn-glycerol-3-phosphate acyltransferase and phosphatidate phosphohydrolase.
A number of agents including a series of 1,3-bis (substituted phenoxy)-2-propanones were screened in vitro for their ability to inhibit hepatic and intestinal microsomal sn-glycerol-3-phosphate acyltransferase and phosphatidate phosphohydrolase. Effective inhibitors reduced in vivo hepatic and intestinal glycerolipid production and with one exception also lowered serum triglyceride levels, suggesting that agents which inhibit potential rate-limiting steps of glycerolipid biosynthesis may be effective hypolipidemic agents. Two compounds, 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate (Sah 42-348) and 1,3-bis (p-methylphenoxy)-2-propanone were the best inhibitors of glycerolipid biosynthesis and lipid-lowering agents. The lipid-altering effects of both drugs were compared to chlorophenoxyisobutyrate during high fructose intake in rats. Each agent reduced fructose induced glycerolipid biosynthesis and serum triglyceride levels to similar degrees.
D000096:Acetone / Q000031:analogs & derivatives / Q000494:pharmacology; D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D006224:Cricetinae; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005632:Fructose / Q000008:administration & dosage; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000037:antagonists & inhibitors*; D006016:Glycolates / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007422:Intestines / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D010647:Phenyl Ethers / Q000494:pharmacology; D010743:Phospholipids / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D051381:Rats; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004791:Enzyme Inhibitors; D006016:Glycolates; D000960:Hypolipidemic Agents; D010647:Phenyl Ethers; D010743:Phospholipids; D014280:Triglycerides; D000096:Acetone; D005632:Fructose; D000217:Acyltransferases; D005992:Glycerol-3-Phosphate O-Acyltransferase; D010744:Phosphoric Monoester Hydrolases