[Chemotherapeutic activity of ifosfamide in 6 different isologously transplanted experimental tumours of BD-rats (author's transl)].
The chemotherapeutic activity of ifosfamide, applied i.v. at a high single dose, was tested on some transplantable tumours of BD-rats. As standard substance cyclophosphamide was used. The margin of safety of ifosfamide in DS-carcinosarcoma and TA-nephroblastoma was found to be wider than that of cyclophosphamide. Therefore, using massive single doses of ifosfamide, rats could be cured of DS-carcinosarcoma in higher percentage than by an analogous treatment with cyclophosphamide. Further, with a single i.v. dose of 280 mg/kg ifosfamide was it possible to cure all TA-nephroblastoma-bearing animals. The ANH-nephroblastoma, however, could not be cured even with the highest tolerable doses of ifosfamide. It was, nevertheless, possible to attain higher increase of life span over the controls than by cyclophosphamide-treatment. In some other isologous tumours ifosfamide proved to be less effective or without any activity, respectively. Pretreatment by repeated small doses of ifosfamide resulted in resistance of DS-carcinosarcoma against curative action of subsequent high single doses of this drug.
D000818:Animals; D002296:Carcinosarcoma / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000031:analogs & derivatives*; D005260:Female; D007069:Ifosfamide / Q000627:therapeutic use*; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D009396:Wilms Tumor / Q000188:drug therapy*
D003520:Cyclophosphamide; D007069:Ifosfamide
Chemotherapeutische Wirksamkeit von Ifosfamid an 6 verschiedenen, isolog transplantierten Experimentaltumoren (BD-Ratten)