Immunocytochemical evidence of SV 40-related T antigen in two human brain tumours of ependymal origin.
A series of thirty-time human brain tumours has been screened for the presence or absence of SV 40-related T antigen by the direct and indirect immunoperoxidase techniques. Two tumours (an ependymoma and a choroid plexus papilloma) of ependymal origin revealed markedly positive nuclear staining for T antigen both in in vivo and in vitro. The possible viral etiology of these human brain tumours is discussed in relation to recent human papovavirus isolates.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism* / Q000382:microbiology; D002831:Choroid Plexus; D003168:Complement Fixation Tests; D006224:Cricetinae / Q000276:immunology; D004806:Ependymoma / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D013539:Simian virus 40 / Q000276:immunology*
D000956:Antigens, Viral