[Hormonal stimulation of adenosine 3',5'-cyclic monophosphate formation in cell-free particles and intact cells of smooth muscle in the aorta and femoral artery of rats during immubilization stress].
The ability of adrenaline and histamine to stimulate the formation of cyclic AMP was investigated in broken cell preparation and intact cells of smooth muscle of the aorta and femoral artery of rats which had been subjected to daily intermittent immobilization for 1, 3, and 17 weeks. It was found that this type of stress led to an instability of the blood pressure which was associated with an increase in the sensitivity of adenylate cyclase in the broken cell preparations from the arteries to adrenaline and histamine and with a heightened cyclic AMP response to the two hormones in the intact arterial smooth muscle cells. The sensitivity of cardiac adenylate cyclase for adrenaline remained unchanged.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D001794:Blood Pressure; D002049:Burimamide / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis*; D004837:Epinephrine / Q000494:pharmacology*; D005263:Femoral Artery / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D006632:Histamine; D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D011738:Pyrilamine; D002049:Burimamide; D004837:Epinephrine
Hormonelle Stimulierung der Bildung von zyklischem Adenosin-3',5'-monophosphat in zellfreien Partikelpäparaten und intakten Zellen der glatten Muskulatur der Aorta und A. femoralis von Ratten im Verlaufe eines Immobilisationsstresses