Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses.
alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptors, on the growth of presynaptic terminals and on the maintenance of their synaptic connections.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002024:Bufo marinus; D002038:Bungarotoxins / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000187:drug effects / Q000648:ultrastructure*; D013569:Synapses / Q000187:drug effects / Q000648:ultrastructure*; D009435:Synaptic Transmission / Q000187:drug effects; D003336:Tectum Mesencephali / Q000187:drug effects / Q000648:ultrastructure*; D013997:Time Factors
D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D000109:Acetylcholine