[Pituitary adenoma with alpha, 17-39 ACTH and beta, MSH cells, without hypercorticism (author's transl)].
In one case of pituitary basophil adenoma, the majority of the cells contains numerous small granulations which, by using immunohistoenzymatic technique, react with alpha, 17-39 ACTH and beta, MSH antisera. The reaction with anti beta, 1-24 ACTH is negative. The radioimmunoassay of ACTH reveals an increase of plasmatic ACTH, but the cortisol cycle stays low. This data suggests that this functional adenoma releases a product of which has an immunological relationship with ACTH, without biological activity.
D000237:Adenoma, Basophil / Q000032:analysis*; D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000097:blood; D000368:Aged; D003594:Cytoplasmic Granules / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D010911:Pituitary Neoplasms / Q000032:analysis*
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D006854:Hydrocortisone
Adénome hypophysaire à cellules à alpha, 17-39 ACTH et beta, MSH sans hypercorticisme.