Bilirubin inhibition of protein kinase: its prevention by cyclic AMP.
The effect of bilirubin on protein kinase activity has been studied. Bilirubin inhibits the binding of cyclic AMP to protein kinase. It also inhibits the phosphorylation of histone. The inhibitory action of bilirubin is competitive, and increased amounts of cyclic AMP relieved the inhibition.
D000818:Animals; D001663:Bilirubin / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D002474:Cell-Free System; D000242:Cyclic AMP / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits
D006657:Histones; D047428:Protein Kinase Inhibitors; D000242:Cyclic AMP; D011494:Protein Kinases; D001663:Bilirubin