[Effect of ascorbic acid on glucocorticoid metabolism in guinea pigs].
Ascorbic acid administered for 18-20 days (daily by 100 mg per 1 kg of weight per os) causes redistribution of certain fractions of 17-OCS excreted with urine (a decrease in the content of free F and F/E ratio, an increase in the content of THF, THE and THS, a more frequent appearance of substances). In the blood plasm and adrenals concentration of 11-OCS rises. When determining the available functional reserves of the adrenal cortex under these conditions, an increase in the content of F, E and S unchanged forms is observed in response to ACTH administration as distinct from the initial state. The rise in concentration of 11-OCS in the adrenals and blood plasm is less pronounced than in the control. A conclusion is drawn that ascorbic acid affects metabolism of glucocorticoids and changes the reaction of the adrenaocortical system on the action of ACTH.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D015065:17-Hydroxycorticosteroids / Q000378:metabolism; D000302:Adrenal Cortex / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004347:Drug Interactions; D005938:Glucocorticoids / Q000378:metabolism*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D013761:Tetrahydrocortisone / Q000378:metabolism
D015062:11-Hydroxycorticosteroids; D015065:17-Hydroxycorticosteroids; D005938:Glucocorticoids; D013761:Tetrahydrocortisone; D000324:Adrenocorticotropic Hormone; D001205:Ascorbic Acid; D006854:Hydrocortisone
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