Immunological selection of tumour cells which have lost SV40 antigen expression.
In an already tumorigenic spontaneously transformed mouse cell, after further transformation by SV40, the virus-specific antigenic function becomes dominant. By transplantation into syngeneic mice SV40 antigen negative revertant tumour cells can be selected out.
D000818:Animals; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells / Q000276:immunology*; D005796:Genes; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude / Q000276:immunology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D013539:Simian virus 40 / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral