[Transport of heterologous DNA in normal and tumor cells and its modification by radiation].
The authors have studied in a comparative way the kinetics of incorporation of labelled heterologous DNA in tumor and nontumor cells of an identical histological type, obtained from non-irradiated and irradiated with 800 rad rats. It has been shown that the process of incorporation of heterologous high-polymer DNA in cells is somewhat undulatory, and its temporal characteristics and level -- tissue-specific. Difference between tumor cells and their normal prototype show a quantitative character, conditioned by a large surface area. 30 minutes following the irradiation qualitative changes opposite for both kinds of cells were observed in the kinetics of incorporation: an acceleration for lymphoyctes and retardation for Pliss lymphosarcoma and Zajdela hepatoma cells.
D000818:Animals; D001692:Biological Transport; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000532:radiotherapy*; D004247:DNA / Q000378:metabolism*; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000532:radiotherapy*; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D051381:Rats
D004247:DNA
Transport geterologichnoĭ DNK v normal'nye i opukholevye kletki i ego radiatsionnaia modifikatsiia