Reliability of the serological method of examination as a basis for diagnosis of associated respiratory virus infections.
The reliability of the results of serological examination in diagnostics of associated infections was studied on a model of artificially provoked vaccinal infections in humans and in laboratory animals. The effect of administered monopreparations on changes in the level of both homologous and heterologous antibodies was tested. The character of immunological changes following simultaneous administration of two or more respiratory viruses was analysed and the effect of these viruses in diseases of divers etiology was studied. According to the results of experiments on laboratory animals, repeated administration of any of the earlier used respiratory viruses stimulated the accumulation of only homologous antibodies while heterologous antibodies did not increase at all.
D000256:Adenoviridae / Q000276:immunology; D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006224:Cricetinae; D003937:Diagnosis, Differential; D006801:Humans; D007114:Immunization; D007252:Influenza Vaccines / Q000008:administration & dosage; D009500:Neutralization Tests; D010919:Placebos; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D012141:Respiratory Tract Infections / Q000175:diagnosis*; D018108:Respirovirus / Q000276:immunology; D012698:Serologic Tests; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage; D014777:Virus Diseases / Q000175:diagnosis*
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010919:Placebos; D014613:Vaccines, Attenuated; D014765:Viral Vaccines