Polyethylene glycol-mediated infection with avian sarcoma viruses.
In this communication we report that fusion of viral and cellular membranes by polyethylene glycol is a convenient approach to overcoming genetically determined resistance to infection. Using this method, avian sarcoma virus-transformed mammalian cells have been produced which serve as useful model systems for the study of Rous sarcoma virus-specific tumor antigens.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001358:Avian Sarcoma Viruses / Q000254:growth & development* / Q000276:immunology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003673:Defective Viruses / Q000254:growth & development; D051379:Mice; D009368:Neoplasm Transplantation; D011092:Polyethylene Glycols / Q000494:pharmacology*; D014181:Transplantation Immunology; D014779:Virus Replication
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D011092:Polyethylene Glycols