Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.
The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.
D000818:Animals; D001665:Binding Sites; D007700:Kinetics; D009206:Myocardium / Q000201:enzymology; D010710:Phosphates / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D011769:Pyruvate Dehydrogenase (Lipoamide)-Phosphatase / Q000378:metabolism*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D013552:Swine
D010710:Phosphates; D010750:Phosphoproteins; D011768:Pyruvate Dehydrogenase Complex; D010744:Phosphoric Monoester Hydrolases; D011769:Pyruvate Dehydrogenase (Lipoamide)-Phosphatase