Murine leukemia virus (T-8)-transformed cells: identification of a precursor polyprotein containing gag gene-coded proteins (p15 and p12) and a nonstructural component.
Mink cells nonproductively transformed by the T-8 strain of mink cell focus-inducing virus express two type C viral amino terminal gag gene-coded structural proteins, p15 and p12, in the form of a 90,000 to 110,000 molecular weight polyprotein that lacks detectable immunological reactivity with other known type C virus-coded translational products. The observation concurs with the previous demonstration of similar high-molecular-weight precursor polyproteins in cell lines nonproductively transformed by either of two other mammalian sarcoma viruses also limited in virus-coded structural protein expression to p15 and p12.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D009052:Leukemia Virus, Murine / Q000254:growth & development* / Q000276:immunology / Q000378:metabolism; D008907:Mink; D008970:Molecular Weight; D011498:Protein Precursors / Q000096:biosynthesis* / Q000276:immunology; D014764:Viral Proteins / Q000096:biosynthesis* / Q000276:immunology
D011498:Protein Precursors; D014764:Viral Proteins