[The protecting action of a combination of vasoactivating substances (CRP) on disturbances of the cerebral blood flow and metabolism and the cortical electrical activity (author's transl)].
The effect of anoxia and direct cortical stimulation was investigated in control, hypotensive and post reinfusional periods, before and after treatment with a combination of coumarin/rutin sulphate sodium salts/proxyphylline (CRP, Theokal). Theokal lowered the mean arterial pressure and a slight NADH oxidation appeared. Blood flow did not change after Theokal in spite of the 30 mm Hg blood pressure drop. This suggests an improved oxygen supply to the cortical cells. The increase in anoxic NADH reaction and the faster reoxidation kinetics of NADH following anoxia provided further evidence for the beneficial effect of Theokal on brain circulation and metabolism. It is to be emphasized that the described action of the drug can be observed only in hemorrhagic shock but not in normal animals.
D000818:Animals; D001578:Benzopyrans / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002540:Cerebral Cortex / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D004338:Drug Combinations; D004569:Electroencephalography; D002534:Hypoxia, Brain; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D012771:Shock, Hemorrhagic; D014970:Xanthines / Q000627:therapeutic use*
D001578:Benzopyrans; D004338:Drug Combinations; D014970:Xanthines; D009243:NAD
Die Schutzwirkung einer durchblutungsfördernden Wirkstoffkombination (CRP) auf Störungen des Stoffwechsels, der Durchblutung und der spontanen kortikalen elektrischen Aktivität des Kortex