Effect of immunization on acute and latent infections of vaginouterine tissue with herpes simplex virus types 1 and 2.
Inoculation of mice with herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) by the vaginal route resulted in viral shedding during the acute phase of the infection and the development of a latent infection in vaginouterine tissue lasting up to one year in greater than 25% of the animals. Immunization with either serotype of HSV markedly reduced viral shedding when animals were subsequently challenged with the homologous serotype, but immunization with HSV-2 was significantly less effective in preventing the development of a latent infection in the vaginouterine tissue after challenge than was immunization with HSV-1.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D003588:Cytopathogenic Effect, Viral; D005260:Female; D005725:Ganglia, Autonomic / Q000276:immunology; D005727:Ganglia, Spinal / Q000276:immunology; D006561:Herpes Simplex / Q000628:therapy*; D007114:Immunization; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000276:immunology*; D014591:Uterine Diseases / Q000628:therapy; D014623:Vaginal Diseases / Q000628:therapy; D014765:Viral Vaccines / Q000627:therapeutic use
D000907:Antibodies, Bacterial; D014765:Viral Vaccines