title: Malignant clear cell acrospiroma.
abstract: The histologic features of a malignant clear cell acrospiroma were those of infiltrative local growth, frequent mitoses and angiolymphatic invasion. The histochemical and ultrastructural findings were similar to those reported for benign clear cell acrospriomas. Amputation of the leg and regional node dissection were required for clinical control. Evaluation of this case and review of the literature suggests that the malignant clear cell acrospiroma often behaves in an aggressive manner and frequently metastasizes. As a consequence, thereapeutic strategies should be appropriately planned.
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D005260:Female; D005528:Foot; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure