Segmental embryonic peripheral neuropathy.
Based on a new interpretation of the radiology, the author has proposed the hypothesis that reduction deformities of the limbs are of sensory neuropathic origin. This hypothesis is examined in terms of the segmental sensory innervation of the skeleton. The predicted effect of sclerotome subtraction is compared with the radiological malformations, and is found to support the hypothesis.
D000014:Abnormalities, Drug-Induced / Q000196:embryology; D000818:Animals; D001132:Arm / Q000294:innervation; D001842:Bone and Bones / Q000294:innervation; D005121:Extremities / Q000254:growth & development; D006801:Humans; D007866:Leg / Q000294:innervation; D017880:Limb Deformities, Congenital; D009416:Nerve Regeneration; D009474:Neurons / Q000502:physiology; D010525:Peripheral Nerves / Q000196:embryology*; D010523:Peripheral Nervous System Diseases / Q000196:embryology; D013792:Thalidomide / Q000009:adverse effects
D013792:Thalidomide