title: On the mechanism of the depressor reaction upon afferent vagal stimulation in cats. II. Role of the beta-adrenergic structures for the development of the depressor reaction.
abstract: Electrical stimulation of the central section of the cervical vagus in cats with bilateral vagotomy results in lowering of the arterial blood pressure. A study is made of the effect of some beta-adrenotropic drugs on the depressor reaction. Propranolol (3 mg/kg i.v.) causes considerable blocking of the depressor reaction in all experiments. On the other hand, Isoprenaline ( a. 10 mug/kh/min) results in a considerable increase of this reaction. The administration of Propranolol (3 mg/kg) and Phentolamine (2 mg/kg) causes almost complete blocking of the reaction. A conclusion is made on the basis of these data that both alpha- and beta-adrenergic structures take part in the realization and development of the depressor reaction upon afferent vagal stimulation.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004347:Drug Interactions; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine