A model for replication of the ends of linear chromosomes.
Linear chromosomes possessing internal repeats of their terminal sequences can form intramolecular crossed-strand exchanges that allow replication of the chromosome ends. Evidence is discussed that such a mechanism may be utilized during replication of herpes simplex virus DNA and during replication of macronuclear DNA from the hypotrichous ciliate Oxytricha.
D000818:Animals; D002875:Chromosomes / Q000378:metabolism*; D016798:Ciliophora / Q000378:metabolism; D004261:DNA Replication; D004279:DNA, Viral / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D008954:Models, Biological; D018139:Simplexvirus / Q000378:metabolism
D004279:DNA, Viral; D004259:DNA-Directed DNA Polymerase