title: [Mechanism of specific vaccine therapy in ocular herpes simplex].
abstract: The mechanism of specific vaccine therapy in herpetic eye disease was studied. The effectiveness of the therapy in the observation period of 3 to 8 years was established. In 71 (62%) of 114 patients relapses of the disease disappeared completely, in 32 (26%) became less frequent and in 11 (10%) their frequency did not change. The clinical course of relapses in all cases became milder. The vaccination courses given were shown not to influence the level of virusneutralizing antibody but to induce the appearance in the lacrimal fluid of immunoglobulins G and M and to increase considerably the level of IgA. The vaccint therapy enhanced the reactions of cell-mediated immunity which was manifested in increased specific blasttransformation of lymphocytes (up to 18%) and reduced the migrational capacity of leucocytes to inactivated antigen of herpesvirus. The effect of the vaccine persisted only for a few months. The immunological and clinical analyses showed that it was expedient to give vaccine in courses at 6--12-month intervals after an attack of herpes.
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007271:Injections, Intradermal; D007635:Keratitis, Dendritic / Q000276:immunology / Q000628:therapy*; D008213:Lymphocyte Activation; D008875:Middle Aged; D018139:Simplexvirus / Q000276:immunology; D013666:Tears / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins; D014765:Viral Vaccines
vernacular_title: O mekhanizme spetsificheskoĭ vaktsinoterapii pri gerpeticheskoĭ bolezni glaz.