Dexamethasone suppression of ovulation in PMS-treated immature rats.
A single injection of 2.0 mg/kg dexamethasone (DXM) administered at 51 h after pregnant mare serum gonadatropin (PMS) treatment inhibited both ovulation and luteinization. S.c. injection of human chorionic gonadotropin (HGG) caused ovulation and luteinization in DXM-PMS-treated rats, whereas treatment with ACTH failed to overcome the DXM inhibitory effect. These findings are interpreted to indicate that DXM inhibits ovulation through a mechanism which might involve the central nervous system.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001835:Body Weight; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D009929:Organ Size; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D051381:Rats; D014599:Uterus / Q000187:drug effects
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone