The metabolism of biogenic amines in experimental animals and in human subjects during acute and chronic administration of ethanol.
Ethanol has been shown to induce a shift in catecholamine metabolism peripherally from normally oxidative pathways to reductive pathways. The mechanisms of this effect may result from competitive inhibition of aldehyde dehydrogenase by acetaldehyde. The shift in metabolism cannot be found in brain and alterations in catecholamine function may reflect changes in the turnover of these amines.
D000079:Acetaldehyde / Q000494:pharmacology; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D009243:NAD / Q000378:metabolism
D001679:Biogenic Amines; D002395:Catecholamines; D009243:NAD; D000431:Ethanol; D000445:Aldehyde Oxidoreductases; D000079:Acetaldehyde