Investigations on the turnover of adrenocortical mitochondria. XI. Effects of dexamethasone on the half-life of mitochondria from the rat zona fasciculata.
The effects of dexamethasone on the half-life of rat adrenocortical mitochondria were investigated by high resolution autoradiography and liquid scintillation spectroscopy. According to the method employed, the half-life averaged 11.27 and 10.46 days. Dexamethasone was found to decrease significantly this parameter (to about 5 days). Since dexamethasone-treated rats can be regarded as pharmacologically hypophysectomized animals, the data indicates that ACTH is involved in the maintenance of the half-life of adrenocortical mitochondria.
D000302:Adrenal Cortex / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone; D000818:Animals; D001345:Autoradiography; D003907:Dexamethasone / Q000494:pharmacology*; D006207:Half-Life; D007016:Hypophysectomy; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013057:Spectrum Analysis
D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone