Cell population kinetics and dose-time relationships for post-irradiation injury of the brachial plexus in man.
Collected data on radiation-induced lesions of the brachial plexus were analyzed on the assumption that this reaction arises from depletion of some unidentified cell population in the irradiated tissues. A multi-probit search program was used to derive best-fitting cell kinetic parameters in a composite multi-target model for cellular radiation lethality and repopulation. From these parameters, a comprehensive iso-effect table, for a wide range of treatment schedules including daily treatment as well as fractionation at shorter and longer intervals, was constructed. The table provides a useful set of tolerance dosage limits for late effects in irradiated peripheral nerve.
D001917:Brachial Plexus / Q000473:pathology / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000532:radiotherapy; D002455:Cell Division / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D003201:Computers; D006801:Humans; D008954:Models, Biological; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*