Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes.
Activation of adenylate cyclase in isolated rat liver plasma membranes by cholera toxin was demonstrated. The activation requires the presence of NAD+ and ATP and is irreversible.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002462:Cell Membrane / Q000201:enzymology; D004789:Enzyme Activation; D008099:Liver / Q000201:enzymology; D009243:NAD / Q000378:metabolism*; D051381:Rats; D014734:Vibrio cholerae
D001427:Bacterial Toxins; D009243:NAD; D000255:Adenosine Triphosphate; D000262:Adenylyl Cyclases