Breast carcinoma following radiotherapy of metastatic Wilm's tumor.
A 22-year-old women developed breast cancer 15 years after radiotherapy to the lung for metastatic Wilms tumor. Her 32-year-old mother died of bilateral breast cancer, suggesting a genetic predisposition to radiogenic cancer. Recent improvements in the survival of children with certain cancers necessitate long-term surveillance for iatrogenic neoplasia, particularly when familial susceptibility is evident.
D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D009362:Neoplasm Metastasis / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary; D009381:Neoplasms, Radiation-Induced; D011878:Radiotherapy / Q000009:adverse effects*; D009396:Wilms Tumor / Q000532:radiotherapy*