Immunofluorescence and histologic studies of virus-induced murine lymphocytic leukemias.
Mice were inoculated with either the lymphatic leukemia virus associated with Friend and Rauscher viruses or with the Graffi or BALB/Tennant leukemia viruses. A total of 48 leukemic mice were examined histologically and by immunofluorescence. All four viruses induced a histologically similar disease that particularly involved tha thymus-dependent lymphoid regions. Lymphocytes from the spleens and thymuses of leukemic animals were examined for Thy-1 antigen and immunoglobulins on the cell surface; all the leukemias were composed of T- cells and/or nonreactive cells lacking both the Thy-1 antigen and immunoglobulins. By immunofluorescence, the spleen and thymus from the same leukemic animal frequently showed different cell-surface markers, though no morphologic differences were seen in leukemias involving the different classes of lymphocytes.
D000818:Animals; D005455:Fluorescent Antibody Technique; D005622:Friend murine leukemia virus; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000209:etiology / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000209:etiology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011925:Rauscher Virus; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology