Relationships between base-exchange in phospholipid metabolism and cyclic-AMP levels of synaptosomal membranes.
The effect of the base-exchange reaction upon the production of cyclic-AMP at the level of rat brain synaptic membranes has been examined. The exchange with ethanolamine produces a significant decrease of the NaF-stimulated production of the cyclic nucleotide, whereas it increases the noradrenaline-induced production. With some exceptions, the exchange with L-serine produces opposite effects.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis*; D004983:Ethanolamines / Q000378:metabolism*; D005260:Female; D008566:Membranes / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012694:Serine / Q000378:metabolism; D012969:Sodium Fluoride / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism*
D004983:Ethanolamines; D012694:Serine; D012969:Sodium Fluoride; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D009638:Norepinephrine