title: Alterations of pulmonary vascular resistance and pulmonary cyclic nucleotide metabolism in the hypoxic pig.
abstract: Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic agents are potent inhibitors of the hypoxia induced vasoconstriction. This effect was associated with an increase of intraparenchymatous cAMP-concentrations and a decrease of cGMP-levels. The regression analysis between pvR versus the ratio cGMP/cAMP revealed a significant linear correlation. These data may indicate, that cAMP and cGMP are involved in hypoxia induced vasoconstriction and its pharmacological inhibition.
mesh_terms: D000818:Animals; D003251:Constriction, Pathologic / Q000209:etiology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D000860:Hypoxia / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D008168:Lung / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D013552:Swine; D014655:Vascular Resistance
chemical_list: D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP