[Mechanisms of the different effect of sucrose on the quantity of lipids in the blood and liver of experimental animals].
Experiments on rats showed that inclusion of sucrose into the composition of diets with increased or normal carbohydrate content accelerated the synthesis in the liver of apoproteins of pre-beta-lipoproteins and their loading with endogenously formed lipids, promoted a more intensive secretion of lipoproteins of very low density into the blood and an increase in it of the triglyceride level. However, the rate of the lipid compensation with the protein of pre-beta-lipoproteins in the liver depends also on the qualitative ratio of the carbohydrate and fat components in the diet. In using the diet with sucrose with the physiological ratio of carbohydrates and fats (2:1) there was noted a lower load of apoproteins of pre-beta-lipoproteins with lipids, this leading to an increase of the latter in the liver.
D000818:Animals; D001059:Apoproteins / Q000096:biosynthesis; D004040:Dietary Carbohydrates; D008055:Lipids / Q000032:analysis* / Q000097:blood; D008079:Lipoproteins, VLDL / Q000096:biosynthesis; D008099:Liver / Q000032:analysis* / Q000378:metabolism; D008297:Male; D051381:Rats; D013395:Sucrose / Q000494:pharmacology*
D001059:Apoproteins; D004040:Dietary Carbohydrates; D008055:Lipids; D008079:Lipoproteins, VLDL; D013395:Sucrose
O nekotorykh mekhanizmakh razlichnogo vliianiia sakharozy na kolichestvo lipidov v krovi i pecheni éksperimental'nykh zhivotnykh.