Functional-morphological correlates of renomedullary interstitial cells.
1. Indomethacin treatment of renomedullary interstitial cells (RIC) causes a marked increase in number and size of their lipid droplets. The anti-hypertensive function is retained. 2. After multiple passages in tissue culture, RIC lose their ability to produce an anti-hypertensive effect in hypertensive animals. Along with this functional loss, lipid droplets and a prominent cisternal system become attenuated or disappear. 3. We conclude that preservation of the lipid granule-cisternal organelle relationship is important in preservation of the anti-hypertensive endocrine function of RIC.
D000959:Antihypertensive Agents; D002479:Inclusion Bodies; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000648:ultrastructure*; D007679:Kidney Medulla / Q000187:drug effects / Q000648:ultrastructure*; D050356:Lipid Metabolism; D008854:Microscopy, Electron
D000959:Antihypertensive Agents; D007213:Indomethacin