[Reactions of tumor and organs of tumor-bearing animals to administration of a synthetic antioxidant].
Alterations of lipid antioxidative activity in liver and tumor as well as change in weight of spleen and tumor were studied in mice with hepatoma-22 after administration of synthetic antioxidant 4-methyl-2,6-ditertbutylphenol (ionol) at doses 30 mg/kg and 100 mg/kg during the 6th day of growth of the tumor. Lipid antioxidative activity was shown to respond similarly to administration of ionol in liver tissue of both the intact and tumor-bearing animals. The antioxidative activity was increased after administration of these doses of the antioxidant, then the antioxidative activity was decreased down to the initial level when the dose 30 mg/kg was used and below this level--at the dose 100 mg/kg. Both doses of the drug increased the lipid antioxidative activity in tumor. The dose 30 mg/kg of ionol stimulated the growth of the tumor and increased the weight of spleen in tumor-bearing animals and the dose 100 mg/kg--inhibited these parameters. Regulation of oxidation of the lipids in tumor appears to be impaired or altered to another level as compared with the oxidation of lipids in normal tissues or in the tissues of tumor-bearing animals.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D003408:Cresols / Q000494:pharmacology*; D050356:Lipid Metabolism; D008113:Liver Neoplasms / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects*
D000975:Antioxidants; D003408:Cresols; D002084:Butylated Hydroxytoluene
Reaktsiia opukholi i organov zhivotnogo-opukholenositelia na vvedenie sinteticheskogo antioksidanta.