title: Studies on the influence of monoamines on the cerebrovascular response to arterial hypoxia.
abstract: The cerebrovascular response to arterial hypoxia  was studied during blockade of the vascular dopamine receptors and during alpha-adrenergic receptor stimulation and blockade in anaesthetized dogs. Dopamine receptor blockade with pimozide or haloperidol invariably decreased the degree of hypoxic vasodilatation in the brain pointing to a functional role of dopamine in this situation. Alpha-receptor blockade did not change the response, while stimulation of these receptors decreased the dilatory response even in deep arterial hypoxia.
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D007275:Injections, Intravenous; D009638:Norepinephrine / Q000008:administration & dosage; D010646:Phentolamine / Q000008:administration & dosage; D010868:Pimozide / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
chemical_list: D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D010868:Pimozide; D006220:Haloperidol; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine