title: Induction of melanogenesis in vitro in the epidermal melanoblasts of newborn mouse skin by MSH.
abstract: The number of epidermal melanocytes positive to the dopa reaction increased when skin explants from newborn mice were cultured with MSH or dbc-AMP. These agents seem to induce melanogenesis in the pre-existing melanoblasts. This hormone-induced melanogenesis is suppressed by actinomycin D or cycloheximide, suggesting that the initiation of melanogenesis in the epidermal melanoblasts requires de novo transcription and translation.
mesh_terms: D000249:Adenosine Monophosphate / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D008543:Melanins / Q000096:biosynthesis*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D008544:Melanocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D014442:Monophenol Monooxygenase / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology
chemical_list: D008543:Melanins; D003609:Dactinomycin; D000249:Adenosine Monophosphate; D004958:Estradiol; D003994:Bucladesine; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D003513:Cycloheximide; D013806:Theophylline; D014442:Monophenol Monooxygenase