title: Effect of cyclic adenosine monophosphate on renal function and renin secretion.
abstract: The effect of cAMP, infused into the renal artery, on renal function and on the release of renin was studied in dogs displaying a normal serum Na level. Intrarenal infusion of 1 mg per kg per minute of cAMP caused a significant increase in RBF, dilatation of the efferent arterioles, the redistribution of renal blood flow and a significant increase in tubular Na-reabsorption. The antidiuretic action of cAMP is due partly to a hemodynamic and partly to a direct tubular effect. Decreased renin secretion was explained by the Na-load on the macula densa segment, being decreased by the intrarenal shifting of renal blood flow and with an eventual decomposition of cAMP.
mesh_terms: D000818:Animals; D003404:Creatinine / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D003404:Creatinine; D000242:Cyclic AMP; D012083:Renin; D010130:p-Aminohippuric Acid