[Effect of insulin on the reactivity of the myocardium to hydrocortisone].
Experiments were conducted on rats. A study was made (with the aid of histological and histochemical methods) of the effect of administration of hydrocortisone, insulin, and also of the combined administration of these hormones on the myocardial structure and metabolism. Hydrocortisone administration for 30 days proved to derange the metabolism and to cause dystrophic changes in the myocardium. In combined administration of hydrocortisone and insulin these dystrophic changes were much less pronounced.
D000110:Acetylcholinesterase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001284:Atrophy; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004336:Drug Antagonism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006854:Hydrocortisone / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
D007328:Insulin; D013438:Sulfhydryl Compounds; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D006005:Phosphorylases; D000110:Acetylcholinesterase; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase; D000251:Adenosine Triphosphatases; D006854:Hydrocortisone
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