[Core and coat of the hepatitis b-virus and cytoplasmic viruslike particles in chronic hepatitis. An electron microscopic study (author's transl)].
In the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (Corticosteroid + Imuran) for chronic active hepatitis (CAH), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft ER in the "ground-glass" hepatocytes were demonstrated by electron microscopy. Core-particles in the cytoplasm were seen occasionally. Dane-particles could not be visualized. Cytoplasmic spherical and ring-shaped virus-like structures (circ. 80 nm in diameter) different from B-virus components and Dane-particle were also found (second virus-infection?). The role of immuno-suppression in the appaerance of viral structures is considered because such particles could not be detected in the first biopsy before therapy when CAH and antigenaemia were already present.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D002467:Cell Nucleus; D004721:Endoplasmic Reticulum; D005260:Female; D006505:Hepatitis / Q000188:drug therapy / Q000473:pathology*; D006515:Hepatitis B virus; D006801:Humans; D002479:Inclusion Bodies; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron
D000305:Adrenal Cortex Hormones; D001379:Azathioprine
Core und Hülle des Hepatitis-B-Virus und zytoplasmatische virusartige Körperchen bei chronischer Hepatitis. Eine elektronenmikroskopische Studie.