The effect of cyclic AMP on the maturation and degranulation of mast cells.
In short-term tissue cultures dibutyryl cAMP inhibits the cortisone-induced degranulation of mast cells. The effect of methylxanthine was found to be similar but developed at a slower rate. The increase of cAMP level also affected the maturation of mast cells, as the ratio of cells of mixed granulation increased, compared to the alcian blue- and safranin-present model inhibited degranulation.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D013997:Time Factors; D014970:Xanthines / Q000494:pharmacology
D014970:Xanthines; D003994:Bucladesine