title: Arterial and coronary sinus catecholamines and cyclic-AMP during dynamic supine exercise in patients with chest pain.
abstract: Arterial and coronary sinus catecholamine concentrations were measured during dynamic exercise in patients to assess the sympathetic response. Arterial concentrations increased from 1.77 nmol/1 (SEM = 0.53, n = 7) (control) to 2.95 nmol/1 (SEM = 0.65, n = 7) during exercise (0.05 greater than P greater than 0.01) and coronary sinus concentrations from 2.78 nmol/1 (SEM = 0.53, n = 7) (control) to 4.43 nmol/1 (SEM = 0.71, n = 7) (0.05 greater than P greater than 0.01). Resting, and exercise, arterial-coronary sinus differences in catecholamine concentrations were not statistically significant. In some patients, higher catecholamine concentrations occurred post-exercise than during exercise. The coronary sinus-arterial difference in catecholamine concentration during exercise was greatest in the one patient who developed angina pectoris. Cyclic-AMP concentrations were also measured, but these did not change significantly, consistent with the predominantly noradrenaline response to exercise.
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000097:blood* / Q000503:physiopathology; D001158:Arteries; D002395:Catecholamines / Q000097:blood*; D003331:Coronary Vessels; D000242:Cyclic AMP / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion
chemical_list: D002395:Catecholamines; D007773:Lactates; D000242:Cyclic AMP