Diencephalic sites responsive to prostaglandin E2 facilitation of sexual receptivity in estrogen-primed ovariectomized rats.
Crystalline prostaglandin E2 (PGE2) induced high levels of sexual receptivity when stereotaxically implanted into the antirior-bala hypothalamic and preoptic regions of estrogen-primed, ovariectomized rats. Anterior- as well as medial basal hypothalamic implants of PGE2 induced a significant elevation of rectal body temperature, but had no effect on open-field activity scores. The possibility that PGE2 exerts its facilitatory effects upon sexual receptivity via an LHRH mechanism is discussed.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D007032:Hypothalamus, Anterior / Q000187:drug effects; D007033:Hypothalamus, Middle / Q000187:drug effects; D011301:Preoptic Area / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013681:Tegmentum Mesencephali / Q000187:drug effects*
D011458:Prostaglandins E; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D004958:Estradiol