title: Malignant (fibrous) histiocytoma arising in association with a bone infarct in sicle-cell disease: coincidence or cause-and-effect?
abstract: A patient with homozygous-S sickle-cell disease complicated by malignant (fibrous) histiocytoma arising within a tibial medullary infarct is reported. This is the ninth reported case of human sarcoma associated with bone infarct and the first associated with sickle-cell disease. Evidence for a causal relationship is presented.
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001859:Bone Neoplasms / Q000150:complications* / Q000209:etiology / Q000473:pathology; D001842:Bone and Bones / Q000098:blood supply; D006644:Histiocytes / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007238:Infarction / Q000150:complications* / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D012509:Sarcoma / Q000150:complications* / Q000209:etiology / Q000473:pathology; D013977:Tibia / Q000098:blood supply*