title: Immunobiology of primary intracranial tumors.
abstract: The avian sarcoma virus-induced glioma model in rats was used to study the effectiveness of immunotherapy, namely, Bacillus Calmette-Guérin (BCG) with or without sarcoma cells and/or chemotherapy with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU), upon survival times. The most consistent prolongation of survival time was produced by triple therapy: BCG + intraperitoneally administered sarcoma cells + intravenously administered BCNU.
mesh_terms: D001355:Alpharetrovirus; D000818:Animals; D001254:Astrocytoma / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D001500:BCG Vaccine; D001932:Brain Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D002330:Carmustine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007167:Immunotherapy / Q000379:methods*; D051381:Rats; D012509:Sarcoma / Q000276:immunology / Q000628:therapy
chemical_list: D001500:BCG Vaccine; D002330:Carmustine