The levels of cyclic GMP and glucose 1,6-diphosphate, and the activity of phosphofructokinase, in muscle from normal and dystrophic mice.
A striking reduction in the levels of glucose 1,6-diphosphate and an increase in cyclic GMP were found in muscle from dystrophic mice. Concomitant to these changes, the allosteric activity of phosphofructokinase was found to be markedly reduced. These findings could offer an explanation for the observed reduction in glycolysis in the dystrophic muscle.
D000494:Allosteric Regulation; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D005958:Glucosephosphates / Q000378:metabolism*; D006019:Glycolysis; D051379:Mice; D009132:Muscles / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D010732:Phosphofructokinase-1 / Q000378:metabolism*
D005958:Glucosephosphates; D000242:Cyclic AMP; D010732:Phosphofructokinase-1; D006152:Cyclic GMP