Phosphatidylethanolamide derivatives of prostaglandins E1 and E2.
Prostaglandins E1 (PGE1) and E2 (PGE2) have been coupled with the amine group of phosphatidylethanolamine (PE) by means of dicyclohexylcarbodiimide. These complexes basically mimic the relaxant and contractile effects of the corresponding free prostaglandins (PGs) on various smooth muscle preparations, but exhibit a delayed onset of action and a lower affinity for the PG receptors. The complexes are comparable with the free, parent PGs, in their intrinsic activities. The same holds true for the effects on blood pressure and on the motility of the uterus in situ. The PGE2-PE complex is hydrolysed to release obviously free PGE2 by cell-free homogenates prepared from various tissues, but not by blood plasma. The PGE2-PE complex is immunologically indistinguishable from the free PGE2.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D003600:Cytosol / Q000378:metabolism; D004024:Dicyclohexylcarbodiimide; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009243:NAD / Q000494:pharmacology; D010714:Phosphatidylethanolamines; D011458:Prostaglandins E / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D010714:Phosphatidylethanolamines; D011458:Prostaglandins E; D009243:NAD; D004024:Dicyclohexylcarbodiimide