[Inhibition of 3-H-noradrenalin uptake in synaptosomes by substance P].
The uptake kinetics of DL-[3H]-norepinephrine into synaptosomes from rat brain hypothalamus can be described as a two stage process with uptake constants of Km = 0.9 micron and Km = 0.06 micron, respectively. Substance P exerts an inhibiting influence on both uptakes. The possible importance of this inhibition for the regulation of noradrenergic transmission is discussed.
D000818:Animals; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013373:Substance P / Q000502:physiology*; D009435:Synaptic Transmission; D013574:Synaptosomes / Q000378:metabolism*
D013373:Substance P; D009638:Norepinephrine
Uber die Hemmung der 3H-Noradrenalin-Aufnahme in Synaptosomen durch Substanz P.