Role of brain monoamines in the anticonvulsant effect of imipramine in albino rats.
The role of brain monoamines in the anticonvulsant effect of imipramine was investigated in albino rats, against maximal electroshock-induced seizures, by using drugs with well-defined effects on brain monoamines. The results suggest a definite role for noradrenaline in imipramine anticonvulsant action. Dopamine and 5-hydroxytryptamine do not appear to be involved in this effect of imipramine.
D000818:Animals; D000927:Anticonvulsants; D001058:Apomorphine / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D004597:Electroshock; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control*; D012701:Serotonin / Q000494:pharmacology
D000927:Anticonvulsants; D002395:Catecholamines; D006892:Hydroxydopamines; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D012701:Serotonin; D008750:Methyldopa; D012110:Reserpine; D004050:Ditiocarb; D011433:Propranolol; D006220:Haloperidol; D001058:Apomorphine; D007099:Imipramine; D010134:Fenclonine; D004298:Dopamine; D009638:Norepinephrine; D008784:Methysergide