Changes in radiosensitivity induced by cyclic nucleotides and chemical radioprotection.
Cyclic AMP has a radioprotective effect and its aministration results in a significant increase in LD50/30 values in Chinese hamsters. The efficiency of these radioprotective effects is comparable to that of such radioprotective compounds as AET and cystamine + mexamine. Cyclic GMP is responsible for significant radiosensitizing effects. Changes in radiosensitivity after administration of cyclic nucleotides are both immediate and delayed and correlate closely with dose and time of administration.
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D006224:Cricetinae; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D003538:Cystamine / Q000494:pharmacology; D009712:Nucleotides, Cyclic / Q000494:pharmacology*; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology
D009712:Nucleotides, Cyclic; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D008735:5-Methoxytryptamine; D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP; D006152:Cyclic GMP; D003538:Cystamine