[Cyclic AMP activation of respiration of the liver mitochondria in different metabolic states].
cAMP 10(-6) activates the liver mitochondria respiration in all the metabolic states and failed to change or increased the phosphorylation rate in the oxidation of saturating concentration of succinate and isocitrate. Preincubation of mitochondria or homogenate of the liver with cAMP is obligatory for this effect. The fraction V of serum albumin and EDTA did not prevent the effect. Noradrenaline enhanced the mitochondrial respiration only in incubation with the homogenate. The effect of noradrenaline and cAMP was not summed up. Probably the noradrenaline effect was mediated through cAMP. The data obtained are against the decisive role of the respiration and phosphorylation uncoupling or the oxidation substrate accumulation and lead to the assumption on the mitochondria enzymes activation.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D007523:Isocitrates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013268:Stimulation, Chemical; D013386:Succinates / Q000378:metabolism
D007523:Isocitrates; D013386:Succinates; D000242:Cyclic AMP; D009638:Norepinephrine
Aktivatsiia tsiklicheskim 3',5'-AMF dykhaniia mitokhondriĭ pecheni v raznykh metabolicheskikh sostoianiiakh.