title: Effect of rubidium, lithium and cesium on brain ATPase and protein kinases.
abstract: The authors studied the effect of rubidium, lithium and cesium on the ATPase system and c-AMP protein kinase in brain. They demonstrated that rubidium could replace potassium in the Na+K-ATPase system, whereas lithium and cesium had no effect on this enzyme activity in the absence of potassium. K+-dependent ATPase was activated by even low rubidium concentrations; lithium and cesium inhibited it. None of three (rubidium, lithium and cesium) affected c-AMP protein kinase.
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002586:Cesium / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008094:Lithium / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D012413:Rubidium / Q000378:metabolism / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
chemical_list: D002586:Cesium; D008094:Lithium; D012964:Sodium; D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D008274:Magnesium; D012413:Rubidium; D011188:Potassium