[Daily periods of aldosterone, sodium, and potassium excretion in the urine of newborns, infants, and children: influence of long-term steroid treatment and of the blockage of adrenergic beta-receptors (author's transl)].
Aldosterone, sodium, and potassium excretion in the urine of six newborns (5, 6, and 9 days), seven infants (2, 3, 4, and 6 months) and eight children (4, 5, 6, 12, and 15 years) was determined at 3-hour intervals during a 24-hour period via gas chromatography and/or flame photometry. The circadian rhythmn of aldosterone excretion could already be ascertained in the 5-day-old newborns. All babies and children examined showed a distinct increase in aldosterone excretion between 3 and 6 am or 6 and 9 am. On the overage, 41% of the total daily amount was excreted between 3 and 9 am. Excretion of sodium and potassium was very low for the newborns and infants. Only in small children and in school children did sodium excretion and the molecular relationship Na/k in urine have a statistically significant negative correlation with the excretion of aldosterone. After long-term prednisone therapy, the maximum amount of aldosterone was excreted in the afternoon. The findings after treatment with propranolol and administration of dexamethasone over a three-day period were similar.
D000293:Adolescent; D000367:Age Factors; D000450:Aldosterone / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002849:Chromatography, Gas; D002940:Circadian Rhythm; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009318:Natriuresis / Q000187:drug effects*; D010783:Photometry; D011188:Potassium / Q000652:urine*; D011241:Prednisone / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D000450:Aldosterone; D003907:Dexamethasone; D011433:Propranolol; D011188:Potassium; D011241:Prednisone
Tagesperiodik der Ausscheidung von Aldosteron, Natrium und Kalium im Harn bei Neugeborenen, Säuglingen und Kindern. Einfluss der langfristigen Steroidbehandlung und der Blockade der adrenergischen beta-Rezeptoren.