The "post-heparin pattern" in routine serum protein immunoelectrophoresis.
For some time following intravenous administration of heparin to non-fasting normal subjects, routine immunoelectrophoretic preparations show characteristic changes in serum lipoproteins. These alterations are of two types: (1) marked anodal mobility increase, the alpha-2 (beta) component locating in the alpha-1 region while the alpha-1 appears as a pre-albumin; (2) conformational alterations of the immunoprecipitin arcs comprising elongation of the alpha-2 (beta) arc, and splitting of the alpha-1 arc into two distinct entities. Familiarity with these patterns should minimize the possibility of interpretative errors with specimens from patients receiving heparin.
D001797:Blood Protein Electrophoresis; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007122:Immunoelectrophoresis; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D011228:Prealbumin / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011228:Prealbumin; D012709:Serum Albumin; D006493:Heparin