title: Involvement of a type-8 avian adenovirus in the etiology of inclusion body hepatitis.
abstract: Type-8 avian adenoviruses were isolated from chickens in a commerical flock suffering an outbreak of inclusion body hepatitis. Serum-neutralizing titer to this type, but not to 7 other types of avian adenovirus, was more than 4 times as high in convalescing chickens as in chickens from the flock bled 2 weeks previously, during the disease outbreak. A disease similar to that in the commercial flock and to inclusion body hepatitis as described in the literature was produced by intra-abdominal inoculation of a type-8 isolant, AMG 5 (2a), into 1-day-old specific-pathogen-free chicks. Pathologic features of the disease included necrotizing hepatitis, pancreatitis, and severe lymphoid depletion of the bursa of Fabricius, thymus, and spleen. It was concluded that type-8 avian adenoviruses were involved in the etiology of the naturally occurring outbreak of inclusion body hepatitis.
mesh_terms: D000257:Adenoviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000259:Aviadenovirus / Q000276:immunology; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D006524:Hepatitis, Viral, Animal / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007181:Inclusion Bodies, Viral; D008099:Liver / Q000473:pathology; D011201:Poultry Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000473:pathology