11,12-Secoprostaglandins. 2. N-acyl-N-alkyl-7-aminoheptanoic acids.
A series of N-acyl-N-alkyl-7-aminoheptanoic acids has been prepared and evaluated for their ability to mimic the natural prostaglandins in certain biological systems. These compounds can be regarded as 8-aza-11,12-secoprostaglandins and, indeed, most of them stimulate cAMP formation in the mouse ovary assay, just as is observed with the natural prostaglandins. Selected compounds from this series also have been studied and shown to have prostaglandin-like effects in vivo.
D000215:Acylation; D000478:Alkylation; D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D000242:Cyclic AMP / Q000096:biosynthesis; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D051379:Mice; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D011453:Prostaglandins / Q000494:pharmacology; D013237:Stereoisomerism
D001372:Aza Compounds; D005227:Fatty Acids; D011453:Prostaglandins; D000242:Cyclic AMP