[Effect of a viral infection on the cellular chromosome apparatus of mice in vitro and in vivo against a background of hydrocortisone action].
A cytogenetic investigation of murine bone marrow after hydrocortison injection has been made. High doses of hormone (50 mg/kg) provoke deteriorations in bone marrow both in the structure and in the chromosome number. A dose of 5 mg/kg has no such effect. The Koksak A13 virus does not induce cytogenetic deteriorations in mice, however, it is able to produce a big mutagenic effect on the hydrocortison background. The vaccine strain of measles virus -- Leningrad-16 -- also increases its mutagenic action on the bone marrow cell chromsome apparatus of mice affected with hydrocortison. At the same time, in the cell culture of murine kidney, hydrocortison does not induce chromosome deteriorations and even lowers the frequency of cells with deteriorations in the chromosome set during the initial days after injecting the virus culture with measles virus.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000382:microbiology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000382:microbiology*; D003384:Coxsackievirus Infections / Q000235:genetics*; D004770:Enterovirus; D006854:Hydrocortisone / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000382:microbiology; D008457:Measles / Q000235:genetics*; D051379:Mice
D006854:Hydrocortisone
Vliianie virusnoĭ infektsii na khromosomnyĭ apparat kletok mysheĭ v usloviiakh in vitro i in vivo na fone vozdeĭstviia gidrokortizonom.