The depolarizing responses to GABA in rat sensory ganglia in vivo and in vitro. A study of the role of glial uptake.
Intracellular recordings of neurones in dorsal root ganglia (DRG) have demonstrated that GABA transport into DRG satellite cell does not affect neuronal responses to this amino acid. The experiments were performed with transport-resistant GABA analogues and with inhibition of GABA uptake. GABA response characteristics can thus be considered exclusively neuronal in origin.
D000818:Animals; D004553:Electric Conductivity; D005727:Ganglia, Spinal / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D009457:Neuroglia / Q000378:metabolism*; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology*
D017981:Receptors, Neurotransmitter; D013654:Taurine; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; C001355:tramiprosate