Isoproterenol in comparison to WR-2721 as a chemoradioprotector of the rat parotid gland.
A comparison was made of the radioprotective abilities of the chemoradioprotector WR-2721, an amino-thiol, and the beta-sympathomimetic secretogogue isoproterenol on the rat parotid gland. Using the dose-response curve of WR-2721 for gland weights as a basis for comparison, isoproterenol was found to offer significant and equal protection during both the acute (DMF, 2.5) and the chronic (DMF, 2.3) periods.
D004999:Amifostine / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D009929:Organ Size; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D011837:Radiation-Protective Agents; D011878:Radiotherapy; D051381:Rats; D013997:Time Factors; D014965:X-Rays
D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D000681:Amylases; D007545:Isoproterenol; D004999:Amifostine