title: [Vitamin D3 sulfoconjugate distribution and evolution in pregnant or lactating rats].
abstract: 24 hrs after intravenous injection of vitamin D3 35S sulfoconjugate the radioactivity in kidney is about twice as much in pregnant Rats as in lactating Rats. It decreases from 24 to 48 hrs in pregnant but increases in lactating Rats kidneys. Hydrolysis of vitamin 3H D3 sulfate is detected in kidney and liver extracts, the ratio of free vitamin D3 on vitamin D3 sulfate is higher in pregnant than in lactating animals. Mammary glands of lactating Rats contain mainly the unchanged vitamin D3 sulfate which can be hydrolysed by new born suckling pups.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002762:Cholecalciferol / Q000097:blood / Q000378:metabolism*; D005260:Female; D006868:Hydrolysis; D007668:Kidney / Q000378:metabolism; D007774:Lactation; D008099:Liver / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D013463:Sulfuric Acid Esters / Q000097:blood / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D013463:Sulfuric Acid Esters; D002762:Cholecalciferol
vernacular_title: Répartition et évolution de la vitamine D3, sulfoconjuguée chez la ratte gestante ou allaitante.