title: Acupuncture in narcotic withdrawal: a preliminary report on biochemical changes in the blood and urine of heroin addicts.
abstract: Eight female heroin-addicted subjects were treated over a 10-day period by acupuncture and electrical stimulation (AES). Their plasma ACTH, cortisol and c-AMP levels were reduced after initial AES treatment. The reduction of c-AMP was significant the most of the three. The suppression of these compounds may be associated with the temporary relief of withdrawl symptoms on and after each AES treatment in the first three days. On the third day, ACTH, cortisol and c-AMP levels did not show significant changes after AES. This was presumably due to the disappearance of withdrawal symptoms and possibly to the stabilizing effect of the treatment. Both the ACTH and c-AMP levels were generally lower at the end of the treatment period. Results of the present investigation suggest that plasma c-AMP may be the best parameter by which to gauge the response of heroin addicts to AES.
mesh_terms: D015670:Acupuncture Therapy; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000450:Aldosterone / Q000652:urine; D002395:Catecholamines / Q000652:urine; D002802:Cholinesterases / Q000097:blood; D002986:Clinical Trials as Topic; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006556:Heroin Dependence / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000628:therapy*; D014642:Vanilmandelic Acid / Q000652:urine
chemical_list: D002395:Catecholamines; D006454:Hemoglobins; D000450:Aldosterone; D014642:Vanilmandelic Acid; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D002802:Cholinesterases; D006854:Hydrocortisone