title: On the possible involvement of ascorbic acid and copper proteins in leukemia. III. ESR investigations on the interaction between ascorbic acid and some transition metal ions.
abstract: The interaction between lyophilized samples of ascorbic acid and Cu2+, Fe3+ or Mn2+ has been investigated by means of ESR spectroscopy. All of the three transition metal ions form complexes with vitamin C, but only in the case of Cu2+ and Fe3+ the interaction results in a reduction of the metal ions. Cu2+ and ascorbic acid seem to form 2 : 1 complexes with an equilibrium constant of about K = 1 X 10(7) mol-1. None of these metal ion complexes exhibits, however, the ESR spectrum obtained with leukemic blood.
mesh_terms: D001205:Ascorbic Acid; D003300:Copper / Q000097:blood; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000032:analysis; D006801:Humans; D007501:Iron; D007938:Leukemia / Q000097:blood*; D008345:Manganese; D008667:Metalloproteins / Q000097:blood; D008968:Molecular Conformation
chemical_list: D008667:Metalloproteins; D008345:Manganese; D003300:Copper; D007501:Iron; D001205:Ascorbic Acid