[Effect of strophanthin and cytochrome C on myocardial contraction and the incidence of shock and ventricular fibrillation in experimental myocardial infarct].
High ligation of the interventricular artery caused ventricular fibrillation in the first 2--4 minutes in 20% of cats. In the remaining animals myocardial contractility diminished to half its initial value. After that, contractility increased gradually. In cardiosclerosis myocardial contractility reduced by 20--30%. Ligation of the interventricular artery on the background of cardiosclerosis induced cardiogenic shock in half of the animals. Cytochrome C does not reduce the diminution of myocardial contractility after ligation and has a marked antifibrillatory effect. Strophantin does not affect the diminution of contractility of a healthy myocardium but reduces the decrease in contractility of a sclerosed myocardium and also promotes the development of ventricular fibrillation following ligation of the interventricular artery.
D000818:Animals; D002415:Cats; D003331:Coronary Vessels / Q000601:surgery; D003574:Cytochrome c Group / Q000494:pharmacology*; D004336:Drug Antagonism; D008026:Ligation; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000503:physiopathology*; D011183:Postoperative Complications / Q000209:etiology; D012770:Shock, Cardiogenic / Q000453:epidemiology* / Q000209:etiology; D013328:Strophanthins / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000453:epidemiology* / Q000517:prevention & control
D003574:Cytochrome c Group; D013328:Strophanthins
Vliianie strofantina i tsitokhroma C na sokratitel'nuiu funktsiiu miokarda, chastotu shoka i fibrilliatsii zheludochkov pri eksperimental'nom infarkte miokarda.