Effect of benzodiazepine compounds on brain amine metabolism.
In mice, chlordiazepoxide, diazepam and flurazepam reduced 5-HT synthesis and metabolism in the teldiencephalon following an i.v. injection of 3H-tryptophan. Only diazepam produced a significant effect in the brainstem. The steady state level of brain 5-HT or of tryptophan was not altered by any of the drugs. Chlordiazepoxide and diazepam, but not flurazepam, decreased the rate of norepinephrine loss from the brain following inhibition of synthesis with alpha-methyltyrosine.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001679:Biogenic Amines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000378:metabolism; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
D014151:Anti-Anxiety Agents; D001679:Biogenic Amines; D001569:Benzodiazepines; D012701:Serotonin; D014364:Tryptophan; D009638:Norepinephrine