Isolation and toxicological study of tetrahydrocannabivarol, an homolog of tetrahydrocannabinol (delta 1--THC).
Selection and culture in a Phytotron of plants of Cannabis sativa L. with high content of propyl-THC are obtained. Then it was possible to isolate a large quantity of propyl-THC by column chromatography. Spectroscopic analysis is done. Pharmacological tests are being run; first results revealed the allergenicity of this substance by comparison with the properties of tetrahydrocannabinol, the active principle of Cannabis.
D000818:Animals; D002188:Cannabis / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000633:toxicity; D004342:Drug Hypersensitivity / Q000209:etiology; D006168:Guinea Pigs; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
C003403:tetrahydrocannabivarin 9; D013759:Dronabinol