Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase.
Because S49 cells are senstivie to killing by cyclic AMP (cAMP), mutants can be selected which have a variety of defects in their ability to generate or respond to cAMP. One class of mutants, that with deficiencies in cAMP-dependent protein kinase, has been extensively characterized genetically and biochemically.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D009374:Neoplasms, Experimental / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism
D003994:Bucladesine; D000242:Cyclic AMP; D011494:Protein Kinases