[Variations of B- and T-lymphocytes in the peripheral blood and variations of the stimulability of cyclic nucleotides in the T-lymphocytes of patients suffering from malignant melanoma (author's transl)].
The portion of B- and T-lymphocytes at the whole white blood count have been estimated in patients with malignant melanoma. An elevation of the B-lymphocytes and a decrease of the T-lymphocytes could be observed in comparison to controls. The CAMP and CGMP level in lymphocytes of patients suffering from melanoma shows a correlation to the degree of metastasing changes. The cyclic nucleotides by mealanoma patients are influenced differently than by normal persons, after addition of physiologic stimulators (isoproterenole, PGE, PGF, acetylcholine). The beta-adrenergic system shows a decreased stimulability and the cholinergic system an increased one depending upon the disease stage in comparison to controls.
D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count; D008545:Melanoma / Q000276:immunology*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009712:Nucleotides, Cyclic / Q000276:immunology*; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology*
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP
Veränderungen des B- und T-Lymphozytenanteiles im peripheren Blut und Veränderungen der Stimulierbarkeit von zyklischen Nukleotiden in den T-Lymphozyten von Patienten mit malignem Melanom.