The effect of bisamidines of 2,6-diaminoanthraquinone on Entamoeba histolytica infections in rats and hamsters.
Bisamidines of 2,6-diaminoanthraquinone have demonstrated potent activity against cecal and hepatic Entamoeba histolytica infections in rats and hamsters, respectively. A number of these compounds compared favorably, in overall drug efficacy, with metronidazole and other standard agents.
D000562:Amebiasis / Q000188:drug therapy*; D000578:Amidines / Q000627:therapeutic use; D000818:Animals; D000880:Anthraquinones / Q000627:therapeutic use*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004748:Entamoeba histolytica; D004749:Entamoebiasis / Q000188:drug therapy*; D005260:Female; D051381:Rats; D013329:Structure-Activity Relationship
D000578:Amidines; D000880:Anthraquinones