Effect of L-glutamate and kainate on rat cerebellar cGMP levels in vivo.
L-glutamate and kainate administered intracerebroventricularly (i.c.v.) both produced dose-dependent increases in rat cerebellar cGMP. The increased cGMP produced by L-glutamate, but not that produced by kainate, could be completely abolished by the glutamate antagonist glutamate diethylester which had no effect alone. The data suggest that L-glutamate and kainate may be acting upon different sub-populations of glutamate receptors, both of which may be involved in the regulation of cerebellar cGMP levels.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D005971:Glutamates; D011759:Pyrrolidines; D006152:Cyclic GMP; D007608:Kainic Acid