[Increased sensitivity of the fatty tissue of rats with spontaneous hypertension to the action of ACTH. The role of calcium].
The action of ACTH on the adipose tissue lypolysis was studied in rats with spontaneous and renal hypertension as well as in normotensive rats of the respective control groups. It was demonstrated that sensitivity of the adipose tissue SHR to ACTH was increased as compared to normotensive controls. The data presented indicate that the increased sensitivity is due to the state or content of intracellular calcium. The rats with renal hypertension did not show such an increased sensitivity of the adipose tissue to ACTH.
D000273:Adipose Tissue / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002413:Cations, Divalent; D005609:Free Radicals; D006973:Hypertension / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002413:Cations, Divalent; D005609:Free Radicals; D000324:Adrenocorticotropic Hormone; D002118:Calcium
Povysliennaia chuvstvitel'nost' zhirovoĭ tkani krys so spontannoĭ gipertonieĭ k deĭstviiu AKTG. RPOL' KAL'TSIIA.