title: Phagocytosis of Coxiella burneti by macrophages.
abstract: Live or killed purified phase I and phase II Coxiella burneti organisms were phagocytized to a similar extent by mouse or guinea pig peritoneal macrophages and polymorphonuclear leukocytes (PMN); phase II was much more susceptible to phagocytosis than phase I. Phagocytosis of phase I was enhanced only by immune sera containing phase I antibodies. Increased in vivo phagocytosis of phase I organisms by macrophages from animals immunized with live phase I C. burneti was lost following their in vitro cultivation and washing.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002478:Cells, Cultured; D003381:Coxiella / Q000166:cytology / Q000276:immunology*; D006168:Guinea Pigs; D007106:Immune Sera; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis
chemical_list: D007106:Immune Sera