Lack of effect of increased pineal serotonin content on H3-tryptophan uptake.
Major increases in the serotonin concentrations of rat pineal organs were produced by administering Catron, a monoamine oxidase inhibitor, prior to autopsy, or by preincubating the glands with serotonin (3X10-4M). These increases had no effect on pineal uptake of H3-tryptophan, the amino acid precursor for serotonin. These observations provide further evidence that the control of serotonin synthesis involves an important "open-loop" component.
D000818:Animals; D006834:Hydrazines / Q000494:pharmacology; D066298:In Vitro Techniques; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*
D006834:Hydrazines; D012701:Serotonin; D014364:Tryptophan