Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.
An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.
D001921:Brain / Q000201:enzymology*; D002243:Carbolines; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000378:metabolism*; D007700:Kinetics; D008745:Methylation; D010880:Piperidines / Q000378:metabolism; D013329:Structure-Activity Relationship; D013763:Tetrahydrofolates / Q000378:metabolism*; D014020:Tissue Extracts; D014363:Tryptamines / Q000378:metabolism*
D002243:Carbolines; D007211:Indoles; D010880:Piperidines; D013763:Tetrahydrofolates; D014020:Tissue Extracts; D014363:Tryptamines; C009762:5-hydroxytryptoline; C009804:tryptoline