[Modelling of a modification of chemical mutagenesis in human cells. II. The dependence of the effect on the time of culture treatment].
The influence of 2,3-aminopropylaminoethylthiophosphoric acid (2,3-APAETP) on the effect of the alkylating agent, thio TEPA, is investigated at different times of cultivation of human peripheral lymphocyte culture. The analysis of correlation equations shows that the results are described by the polynomes of 4-degree in variants treated with thioTEPA and 2,3-APAETP. The protector effect of 2,3-APAETP is determined not by the time from the culture stimulation but the time between the moment of culture treatment with 2,3-APAETP and thioTEPA and the moment of the fixation. It is shown that the points of maximal sensitivity of the cell cycle to thioTEPA and to the protective effect of 2,3-APAETP are similar.
D004999:Amifostine / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008433:Mathematics; D008954:Models, Biological; D009154:Mutation / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology; D013997:Time Factors
D013852:Thiotepa; D004999:Amifostine
Modelirovanie modifikatsii khimicheskogo mutageneza v kletkakh cheloveka. Soobshchenie II. Zavisimost' éffekta ot vremeni obrabotki kul'tur.