[Na, K-ATPase activity of the meninges in electroshock and the action of the anticonvulsant agent, diazepam].
It was shown that the phenomenon of inactivation of Na, K-ATPase of the non-purified fraction of the rat cortical synaptosomes under electroshock may be related to "modification" of the potassium active center of the enzyme. The anticonvulsant diazepam injected intramuscularly also inhibits Na, K-ATPase of the cerebral membranes. However, in subsequent electrical stimulation of the brain the drug activates Na, K-ATPase as compared to controls. Diazepam also abolishes clonic convulsions induced by electrical stimulation of the brain. At the same time it does not eliminate compensatory shifts in the activity of acetyl-cholinesterase of the rat cerebral and spinal synaptosomes, characteristic of electroshock. The results are discussed from the standpoint that inhibition of the activity of Na, K-ATPase of the nerve endings membranes may underlie the pathogenetic mechanism of the convulsive activity.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000927:Anticonvulsants; D002540:Cerebral Cortex / Q000201:enzymology; D003975:Diazepam / Q000494:pharmacology*; D004597:Electroshock; D004789:Enzyme Activation / Q000187:drug effects; D008578:Meninges / Q000201:enzymology*; D051381:Rats; D012640:Seizures / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013116:Spinal Cord / Q000201:enzymology; D013574:Synaptosomes / Q000201:enzymology
D000927:Anticonvulsants; D000110:Acetylcholinesterase; D000254:Sodium-Potassium-Exchanging ATPase; D003975:Diazepam
Aktivnost' Na, K-ATF-azy membran mozga pri élektroshoke i deĭstvii protivosudorozhnogo agenta diazepama.