Inhibition and promotion of growth of B77-virus-induced rat tumor with KCl-solubilized tumor cell components.
Rats were immunized with a single and repeated doses (1.0 mg of protein per dose per animal) of KCl-solubilized thymus and avian sarcoma virus B77-induced rat tumor cells LWF B77 prior to challenge with the same tumor cells. Results obtained showed that single administration of KCl-solubilized tumor cell material resulted in inhibition of growth of syngeneic tumor cells. Repeated inoculations of the same material, however, promoted tumor growth. Possible explanation of this dual effect is discussed.
D000818:Animals; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D007114:Immunization; D009374:Neoplasms, Experimental / Q000276:immunology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D013950:Thymus Gland / Q000276:immunology; D014185:Transplantation, Isogeneic
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D011189:Potassium Chloride