Effect of changes in cyclic nucleotide levels on human antibody-dependent cellular cytotoxicity.
The effect of agents influencing intracellular cyclic nucleotide levels and that of exogenous cAMP was studied on the cytotoxicity of normal human peripheral blood mononuclear cells on antibody coated human and chicken erythrocytes. Elevation of the cAMP level resulted in a marked decrease in cytotoxicity, while basically similar in the allogeneic and the xenogeneic test systems, but more expressed in the allogeneic system.
D000109:Acetylcholine / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology; D002645:Chickens; D000242:Cyclic AMP / Q000378:metabolism / Q000494:pharmacology; D006152:Cyclic GMP / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000097:blood / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology
D009712:Nucleotides, Cyclic; D000628:Aminophylline; D003994:Bucladesine; D012969:Sodium Fluoride; D011433:Propranolol; D000242:Cyclic AMP; D006152:Cyclic GMP; D000109:Acetylcholine; D004837:Epinephrine