Suppression of induced beta-galactosidase synthesis by cysteamine and its reversion by gamma-irradiation in the presence of ascorbate.
The induced synthesis of beta-galactosidase in E. coli was found to be inhibited by cysteamine. This inhibitory effect of the SH compound was antagonized by the addition of ascorbate followed by gamma-irradiation with relatively low doses. The cAMP level which, it has been suggested, plays a role in the radioprotective action of cysteamine, is stabilized by ascorbate against changes induced by irradiation.
D001205:Ascorbic Acid / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D003543:Cysteamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D005696:Galactosidases / Q000096:biosynthesis*; D005720:Gamma Rays; D011837:Radiation-Protective Agents; D001616:beta-Galactosidase / Q000096:biosynthesis* / Q000528:radiation effects
D011837:Radiation-Protective Agents; D003543:Cysteamine; D000242:Cyclic AMP; D005696:Galactosidases; D001616:beta-Galactosidase; D001205:Ascorbic Acid