Streptozotocin treatment of a pancreatic tumour producing VIP and gastrin associated with Verner-Morrison syndrome.
A 57-year-old male patient with metastasizing non-beta islet cell carcinoma of the pancreas is described. Both gastrin and VIP levels were elevated and the patient suffered from a syndrome of pancreatic cholera and hyperacidity. The tumour contained gastrin and VIP as demonstrated by immunofluorescence. The patient also had a history of familial renal stone formation and parathyroid nodular hyperplasia. Resection of pancreatic tumour in 1973 resulted in four years without symptoms. In 1977 definite signs of multiple hepatic metastases appeared. These signs disappeared after streptozotocin given in a dosage of 2 g three times at weekly intervals. The patient had remained well for 20 months after this treatment. The causative agents for the clinical syndrome in this case are discussed in view of circulating hormone levels.
D058186:Acute Kidney Injury; D007516:Adenoma, Islet Cell / Q000188:drug therapy* / Q000378:metabolism; D003681:Dehydration; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000097:blood; D013311:Streptozocin / Q000008:administration & dosage / Q000627:therapeutic use*; D013577:Syndrome; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000378:metabolism*
D005755:Gastrins; D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D010191:Pancreatic Polypeptide; D013311:Streptozocin