Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline.
Cellular DNA synthesis induced by simian virus 40 mutants that lack t antigen is sensitive to concentrations of theophylline that do not affect wild-type-induced synthesis.
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis*; D000882:Haplorhini; D007668:Kidney; D009154:Mutation; D013539:Simian virus 40 / Q000235:genetics / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology*; D013937:Thymidine Kinase / Q000096:biosynthesis
D000956:Antigens, Viral; D004247:DNA; D013806:Theophylline; D013937:Thymidine Kinase