GFA and S 100 protein levels as an index for malignancy in human gliomas and neurinomas.
Human glia-specific proteins S 100 and GFA were quantitated by use of a rocket immunoelectrophoresis technique with monospecific antisera. No relation was found between the S 100 protein content of an astrocytoma and its degree of neoplasia. However, the lower the GFA protein content of the astrocytoma, the more malignant it was. Similarly, the more malignant a neurinoma was, the lower was its S 100 protein content. Therefore, the levels of these proteins might be used as indexes of neoplastic dedifferentiation.
D001254:Astrocytoma / Q000032:analysis*; D001932:Brain Neoplasms / Q000032:analysis; D002454:Cell Differentiation; D005909:Glioblastoma / Q000032:analysis*; D006801:Humans; D007122:Immunoelectrophoresis; D009363:Neoplasm Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009442:Neurilemmoma / Q000032:analysis*; D010524:Peripheral Nervous System Neoplasms / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D009418:S100 Proteins