Inhibition of foot and mouth disease virus and procapsid synthesis by zinc ions. Brief report.
Zinc ions inhibit virus production and viral RNA synthesis in FMDV infected-BHK 21 cells. The degree of inhibition depends upon the zinc concentration and the time of addition of the drug. A differential inhibition on virus and procapsids synthesis was observed.
D000818:Animals; D005537:Aphthovirus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002213:Capsid / Q000096:biosynthesis*; D002460:Cell Line; D006224:Cricetinae; D007668:Kidney; D009024:Morphogenesis / Q000187:drug effects; D012367:RNA, Viral / Q000096:biosynthesis; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology*
D012367:RNA, Viral; D014764:Viral Proteins; D015032:Zinc