Infectious bursal disease viral infections. II. The relationship of age, complement levels, virus-neutralizing antibody, clotting, and lesions.
Experimental infection with infectious bursal disease virus (IBDV) reduced the complement (C) titer in 8-week-old chickens on days 3, 5, and 7 postinfection. Since the C titer was much lower in normal 2-week-old chickens than in normal 8-week-old chickens it could not be determined whether there was a reduction in titer during the infection process. Virus-neutralizing antibody rose rapidly following infection in both 2- and 8-week-old chickens. Hyper-immune serum given during infection in an attempt to produce immune complexes did not increase disease severity in either 2- or 6-week-old susceptible chickens.
D000375:Aging; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000936:Antigen-Antibody Complex; D001777:Blood Coagulation; D002060:Bursa of Fabricius / Q000382:microbiology; D002645:Chickens; D003165:Complement System Proteins / Q000378:metabolism*; D007243:Infectious bursal disease virus / Q000276:immunology*; D011201:Poultry Diseases / Q000503:physiopathology*; D012087:Reoviridae / Q000276:immunology*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D003165:Complement System Proteins