The role of interferon in virus infections and antibody formation.
Virus-type interferon is capable of suppressing the antibody response both in vivo and in vitro. Interferon induced by antigen or mitogen (immune interferon), primarily in T-lymphocytes, also appears capable of suppressing the antibody response. Cyclic AMP has a regulatory effect on the induction of both virus-type and immune interferon. The immunosuppressive effects of virus-type and immune interferon may differ at the cellular or subcellular level.
D000818:Animals; D000917:Antibody Formation; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D002644:Chickenpox / Q000628:therapy; D003139:Common Cold / Q000628:therapy; D000242:Cyclic AMP / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000628:therapy; D006509:Hepatitis B / Q000628:therapy; D006561:Herpes Simplex / Q000628:therapy; D006801:Humans; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007372:Interferons / Q000096:biosynthesis / Q000502:physiology*; D008214:Lymphocytes / Q000276:immunology; D011818:Rabies / Q000628:therapy; D014777:Virus Diseases / Q000276:immunology*
D003994:Bucladesine; D007372:Interferons; D000242:Cyclic AMP