Recognition of viral antigens in 6/94 virus-induced T-cell-mediated cytotoxicity.
Distinct events in the virus-stimulated T-cell-mediated cytotoxicity (V-CMC) have been investigated: 1.) The induction of V-CMC is possible by immunizing mice with infectious as well as UV-inactivated virus (parainfluenza type 1 strain 6/94), or with virus-infected cells either compatible or imcompatible with the recipient. 2). Recognition of viral antigens by the effector cells occurs independently of the H2 environment: Fractionation of effector cells on columns loaded with virus-infected cells eliminates virus-specific cytotoxic cells. Effector cells and cells on the column need not share H-2 antigens. The findings are discussed with regard to the H2 restriction of the virus induced T-cells mediated cytotoxicity.
D000818:Animals; D000956:Antigens, Viral; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006648:Histocompatibility; D007111:Immunity, Cellular; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral; D006183:H-2 Antigens