Adenosine 3':5'-monophosphate-dependent in vitro phosphorylation of synaptosomal membrane proteins from rat corpus striatum following systemic administration of L-DOPA and bromocriptine.
In vitro phosphorylation of synaptosomal membrane preparation from rat striata was stimulated by addition of 5 microM cAMP, Administration of L-DOPA to rats treated previously with an L-amino acid decarboxylase inhibitor, or administration of bromocriptine resulted in a marked decrease in the in vitro phosphorylation presumably by increasing endogenous cAMP levels and thereby stimulating endogenous protein phosphorylation.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology*; D066298:In Vitro Techniques; D007980:Levodopa / Q000494:pharmacology*; D008565:Membrane Proteins / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D013268:Stimulation, Chemical; D013570:Synaptic Membranes / Q000378:metabolism*
D008565:Membrane Proteins; D001971:Bromocriptine; D007980:Levodopa; D001545:Benserazide; D000242:Cyclic AMP