title: Liver tumours and the contraceptive pill: Controversies in aetiology, diagnosis and management.
abstract: Six female patients seen at Groote Schuur Hospital between 1973 and 1977, with the types of liver lesion that have been linked aetiologically with the contraceptive pill, are described. Four had focal nodular hyperplasia (1 with spontaneous rupture), and 1 patient had a hepatocellular carcinoma. The sixth patient had spontaneous rupture of the liver but no tumour was demonstrated. Based on this experience and a review of the literature, controversies in aetiology, diagnosis and managment are presented. A defined management policy is proposed for the benign lesions, a less aggressive approach being advocated for focal nodular hyperplasia than for hepatic adenoma.
mesh_terms: D000236:Adenoma / Q000139:chemically induced; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D003276:Contraceptives, Oral