title: Endopeptidases in the brush border of the kidney proximal tubule.
abstract: Among the five peptidase known to be located in the microvillus membrane of the renal proximal tubule are two enzymes with endopeptidase activity. Neutral endopeptidase, a zinc-dependent enzyme, has a broad specificity comparable to that of thermolysin, and like the latter may be specifically inhibited by phosphoramidon. Dipeptidyl peptidase IV, a serine enzyme, is very sensitive to inhibition by diisopropyl phosphorofluoridate. It is also capable of endopeptidase activity, hydrolysing bonds involving the carboxyl group of proline.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D010450:Endopeptidases / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000201:enzymology*; D007700:Kinetics; D008871:Microvilli / Q000201:enzymology*; D009842:Oligopeptides; D011817:Rabbits; D013379:Substrate Specificity; D013552:Swine
chemical_list: D009842:Oligopeptides; D010450:Endopeptidases