title: Glucagon administration decreases hepatic nuclear triiodothyronine binding capacity.
abstract: The maximal binding capacity (MBC) of nuclear triiodothyronine (T3) receptor sites in rat liver decreases markedly after glucagon administration. Administration of serial doses of glucagon (2.5 microgram/100 g BW) resulted in a 33% decrease in MBC in 3.5 h and MBC was reduced by 45% in 6.25 h. The individual doses used were in the same order of magnitude as those used in the treatment of hypoglycemic human subjects (1.5 microgram/100 g BW). This report presents the first evidence that a peptide hormone can change the number of nuclear T3 receptor sites. The physiological significance of these findings remains to be clarified.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D014284:Triiodothyronine; D005934:Glucagon