Drugs affecting the cholinergic system in the intact mammalian eye. I. Evaluation of the miotic activity of acetylcholine-like drugs in the mouse eye.
The effect of concentration and pH on the miotic activity of five acetylcholine-like drugs were studied in the intact mouse eye. The data suggests that it is mainly the nonionized form of the drug which contributes to its miotic activity. Acetylcholine-like drugs, degradable by cholinesterases, exert their miotic activity at higher concentrations than do those which are resistant to enzymatic hydrolysis. More active acetylcholine-like drugs appear to be less sensitive to concentration changes.
D000109:Acetylcholine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001115:Arecoline / Q000008:administration & dosage / Q000494:pharmacology; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D008916:Miotics / Q000494:pharmacology*; D010095:Oxotremorine / Q000008:administration & dosage / Q000494:pharmacology; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D011812:Quinuclidines / Q000008:administration & dosage / Q000494:pharmacology
D008916:Miotics; D011812:Quinuclidines; D001115:Arecoline; D010095:Oxotremorine; D002217:Carbachol; D010622:Phencyclidine; D000109:Acetylcholine