The actions of enkephalins are not modified by the "kininase-II" inhibitor captopril.
The "kininase-II" (EC 3.4.15.1) inhibitor captopril in concentrations up to 10(-4) M did not affect the actions of enkephalins on the isolated electrically stimulated guinea-pig ileum. Captopril (100 mg/kg i.p.) in mice did not influence stimulation-produced analgesia and did not show analgesic properties. It is concluded that "kininase-II" is not involved in enkephalin catabolism, since the pharmacological actions of enkephalins were not enhanced after inhibition of the enzyme by captopril.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011392:Proline / Q000031:analogs & derivatives*; D011930:Reaction Time / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D004723:Endorphins; D004745:Enkephalins; D011392:Proline; D002216:Captopril