Primary immunodeficiency and malignancy.
Evidence indicating an essential relationship between immunologic deviation and cancer has accumulated rapidly over the past 15 years. Following a brief review of the enormous body of literature linking experimental immunodeficiency and cancer, this discussion will center on humans with primary immunodeficiency disorders and the inordinate number of malignancies which develop in these patients.
D000361:Agammaglobulinemia / Q000150:complications; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D006087:Graft vs Host Reaction; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D009052:Leukemia Virus, Murine / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000209:etiology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008212:Lymphocyte Depletion; D008223:Lymphoma / Q000209:etiology; D051379:Mice; D009369:Neoplasms / Q000209:etiology*; D013539:Simian virus 40 / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000209:etiology