Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing.
The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants seem to lack a functional trans-acting RNA required for the processing of both messengers. In contrast, the oxi-3 mutants may act by producing an activity that inhibits specific steps.
D003580:Cytochromes / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics; D005796:Genes; D008928:Mitochondria; D009154:Mutation; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D012331:RNA, Fungal / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics*
D003580:Cytochromes; D009694:Nucleic Acid Precursors; D012331:RNA, Fungal; D012333:RNA, Messenger; D003576:Electron Transport Complex IV