Meningitis developing during cephalothin therapy of septicaemia.
A 63-year-old woman developed pneumococcal meningitis during cephalothin treatment for pneumococcal septicaemia. The poor penetration of this antibiotic over the blood-brain barrier makes it unsuitable for the therapy of meningitis. If cephalothin is used in other serious infections, the patient should be closely observed for the development of meningitis.
D001812:Blood-Brain Barrier; D002512:Cephalothin / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000209:etiology*; D008875:Middle Aged; D018805:Sepsis / Q000150:complications / Q000188:drug therapy*; D013296:Streptococcus pneumoniae / Q000302:isolation & purification
D002512:Cephalothin