Effects of monosodium glutamate on chick embryo retina in culture.
Monosodium glutamate added to 12-day chick embryo retinas in culture causes severe morphologic damage to the retina as judged by light microscopic examination. Damage is evident after a few hours with concentrations as low as 0.3 mM. Glutamyltransferase induction is also appreciably inhibited by the amino acid. General protein synthesis and RNA synthesis appear to be less affected.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D002642:Chick Embryo; D046508:Culture Techniques; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D005973:Glutamine / Q000494:pharmacology; D006652:Histological Techniques; D006854:Hydrocortisone / Q000494:pharmacology; D010649:Phenylalanine / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000596:Amino Acids; D002250:Carbon Radioisotopes; D005971:Glutamates; D005973:Glutamine; D014316:Tritium; D010649:Phenylalanine; D012313:RNA; D005723:gamma-Glutamyltransferase; D006854:Hydrocortisone