Glucagon stimulated plasma cyclic adenosine-3',5'-monophosphate in the differential diagnosis of jaundice.
The amount of plasma cyclic adenosine-3',5'-monophosphate was estimated before and 15 minutes after the intravenous injection of 1 milligram of glucagon in 34 patients with obstructive and in 23 patients with nonobstructive jaundice. After stimulation with glucagon, the median adenosine-3',5'-monophosphate concentration in obstructive jaundice rose fortyfold or more, while in nonobstructive jaundice, the increase was twentyfold or less. The difference was highly significant. The results indicate that this test can be useful in the differential diagnosis of obstructive and nonobstructive jaundice.
D002779:Cholestasis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D000242:Cyclic AMP / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D005934:Glucagon; D006801:Humans; D007565:Jaundice / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
D005934:Glucagon; D000242:Cyclic AMP