The influence of insulin, cAMP and the calcium ionophore X 537 A on the growth of the cartilage analagen of limb buds in vitro.
Limb buds of 11-day-old mouse embryos were cultured for 6 days with insulin, dibutyryl cAMP and X 537 A. The cartilage anlage was reduced by insulin and enlarged by dibutyryl cAMP and X 537 A. The effects are due to changes in the amount of intercellular substance.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002356:Cartilage / Q000187:drug effects / Q000196:embryology* / Q000648:ultrastructure; D004622:Embryo, Mammalian; D007328:Insulin / Q000494:pharmacology*; D007832:Lasalocid / Q000494:pharmacology*; D051379:Mice
D007328:Insulin; D003994:Bucladesine; D002118:Calcium; D007832:Lasalocid