[Theoretical aspects of fighting cancer recurrence (author's transl)].
The noticeable improvement in the supply of glucose and oxygen to surviving cancer cells located far from the capillary region (primarily very slowly proliferating or non-proliferating cancer cells) can be taken as the main reason for cancer recurrence in the wake of successful tumour treatment with destruction of a high percentage of cancer cells. On the basis of theoretical and experimental research work on substrate supply, cell kinetics and therapy mechanisms in the intercapillary region, therapeutic steps are formulated which act on cancer cells situated at a greater distance from the capillaries and, therefore, against the genesis of cancer recurrence as such.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001786:Blood Glucose; D002196:Capillaries / Q000378:metabolism*; D002455:Cell Division; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007165:Immunosuppression Therapy; D007700:Kinetics; D008247:Lysosomes / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D010101:Oxygen Consumption; D011879:Radiotherapy Dosage
D000970:Antineoplastic Agents; D001786:Blood Glucose; D005947:Glucose
Theoretische Aspekte der Bekämpfung von Krebs-Rezidiven. Gesetzmässigkeiten der Substratversorgung, der Zellkinetik und der Therapiemechanismen im Interkapillarraum der Krebsgewebe