[Determination of the individual sensitivity of human glial tumors to the action of chemotherapeutic preparations].
Individual sensitivity of 40 glial tumors (34 macroglial and 5 oligodendroglial tumors and 1 medulloblastoma) to 4 chemotherapeutical agents (fluorofur, 5-fluorouracil, methotrexate and sarcolysin) was studied in vitro on the basis of changes in the values of thymidine labelling index after 24-hour incubation of tumor-tissue fragments in a medium with the chemical agents. Each of the tumors studied possessed individual range of sensitivity to the chemotherapeutical agents distinguishing it from other tumors. None of the agents studied proved to more effective than others. The reaction of the tumor tissue to the effect of the chemotherapeutical agents did not depend on the proliferative activity of the tumor, while the degree of manifestation of the tumor reaction was often dependent on the concentration of the agents. An increase in the number of DNA-synthesizing cells in the tumor under the effect of the chemical agents was observed in rare cases.
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001254:Astrocytoma / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy; D005472:Fluorouracil / Q000627:therapeutic use; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D066298:In Vitro Techniques; D008527:Medulloblastoma / Q000188:drug therapy*; D008558:Melphalan / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009837:Oligodendroglioma / Q000188:drug therapy*; D005641:Tegafur / Q000627:therapeutic use
D000970:Antineoplastic Agents; D005641:Tegafur; D008558:Melphalan; D005472:Fluorouracil; D008727:Methotrexate
Opredelenie individual'noĭ chuvstvitel'nosti glial'nykh opukholeĭ cheloveka k deĭstviiu khimioterapevticheskikh preparatov.