title: [Antiviral chemotherapeutic agents. XVIII. Adamantane derivatives of amphetamine. Their potential interest as autonomic and antiparkinson agents].
abstract: Adamantane isologs of amphetamine, methamphetamine and pheniprazine and several derivatives were synthesized in order to study the influence of their more pronounced lipophilic characteristics on their biological properties. A preliminary examination of their toxicity, antiviral, CNS stimulant and antiparkinson activity is described. The adamantyl amphetamine, which proved active, will be further studied.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000662:Amphetamines; D000978:Antiparkinson Agents; D000998:Antiviral Agents; D001337:Autonomic Agents; D002490:Central Nervous System / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006834:Hydrazines / Q000494:pharmacology*
chemical_list: D000662:Amphetamines; D000978:Antiparkinson Agents; D000998:Antiviral Agents; D001337:Autonomic Agents; D006834:Hydrazines; D000661:Amphetamine; D000218:Adamantane
vernacular_title: Chemioterapici antivirali. Nota XVIII - Amfetamina adamantilica e derivati. Loro potenziale interesse anche come farmaci autonomici ed antiparkinsoniani