Bile aspiration: an experimental study in rabbits.
It has been shown that bile injected intratracheally in rabbits produces severe pulmonary edema, atelectasis, and focal hemorrhages. The authors investigated the effect of a number of solutions, including physiological concentration of bile, hydrochloric acid pH 1.0, bile salt diluted to 1%, and bile at 100% concentrations. Whenever the bile concentration exceeded 3%, none of the test animals survived. It is not possible to apply directly the results of an experimental animal study to humans. However, the severity of the pulmonary changes produced force the conclusion that bile is a potentially dangerous aspirate in humans.
D000818:Animals; D001646:Bile; D001647:Bile Acids and Salts / Q000009:adverse effects; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006851:Hydrochloric Acid / Q000009:adverse effects; D006863:Hydrogen-Ion Concentration; D001239:Inhalation; D007267:Injections; D008171:Lung Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011015:Pneumonia, Aspiration / Q000175:diagnosis; D001261:Pulmonary Atelectasis / Q000139:chemically induced; D011654:Pulmonary Edema / Q000139:chemically induced; D011817:Rabbits; D011859:Radiography; D013656:Taurocholic Acid / Q000009:adverse effects; D014132:Trachea / Q000503:physiopathology
D001647:Bile Acids and Salts; D013656:Taurocholic Acid; D006851:Hydrochloric Acid