Evidence for herpes simplex virus type-selective receptors on cellular plasma membranes.
Herpes simplex virus type 1 (HSV-1) interfered with the adsorption of subsequently added homotypic but no heterotypic HSV, suggesting that the cellular receptors involved were type-selective. Both infective and u.v.-irradiated virus could block the attachment of virions to cellular surface receptors. The adsorption rate was studied by assaying non-adsorbed infective virus remaining in the fluid medium and cell-associated 3H-thymidine labelled HSV, and HSV mutants assayed in presence of phosphonoformic acid (PFA). The adsorption profiles indicated that GMK AH-1, Vero and SIRC cells all exhibited more HSV type 1-than type 2-selective receptors while HeLa S3 cells displayed more receptors with affinity for type 2 than for type 1. On HEp-2 and human embryonic lung cells HSV type 1- and type 2-selective receptors were about equally represented.
D000327:Adsorption; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis*; D003315:Cornea; D000882:Haplorhini; D006367:HeLa Cells; D006801:Humans; D007668:Kidney; D007822:Laryngeal Neoplasms; D008168:Lung / Q000196:embryology; D011817:Rabbits; D011991:Receptors, Virus / Q000032:analysis*; D018139:Simplexvirus / Q000254:growth & development*; D014762:Viral Interference; D014779:Virus Replication
D011991:Receptors, Virus