Attempted immunologic reconstitution of patients with combined immune deficiency syndrome with bone marrow transplantation from histoincompatible donors.
The immunologic reconstitution from patients with combined immune deficiency syndrome was attempted with bone marrow transplantation from histoincompatible donors. None of the patients achieved long-term immunologic reconstitution. In all cases, the incompatible bone marrow was treated before transplantation. Physical separation of the stem and immunocompetent cells was attempted in 2 cases with the use of enhancing antibody in one of the attempts. The selective destruction of the immunocompetent bone marrow cells after specific stimulation was attempted in the last 2 cases.
D000921:Antibody-Producing Cells; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D001973:Bromodeoxyuridine; D002469:Cell Separation; D005838:Genotype; D006087:Graft vs Host Reaction; D006412:Hematopoietic Stem Cells; D006648:Histocompatibility; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000628:therapy*; D010375:Pedigree; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous; D014316:Tritium
D014316:Tritium; D001973:Bromodeoxyuridine; D013936:Thymidine