Preparation of radiolabeled thyroid-stimulating immunoglobulins (TSI) by recombining TSI heavy chains with 125I-labeled light chains: direct evidence that the product binds to the membrane thyrotropin receptor and stimulates adenylate cyclase.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007700:Kinetics; D008135:Long-Acting Thyroid Stimulator; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism
D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D011956:Receptors, Cell Surface; D013972:Thyrotropin; D008135:Long-Acting Thyroid Stimulator; D000262:Adenylyl Cyclases