Traumatic hypopituitarism: anterior hypophyseal insufficiency from indirect cranial trauma.
We have reported a case of partial hypopituitarism involving deficient ACTH, LH, FSH, and growth hormone production and elevated prolactin. The hypopituitarism was caused by injury to the pituitary resulting from a parachute accident without direct craniocerebral trauma. The pathogenesis of this pituitary injury as either a clivus fracture near the sella, unilated abstruction of the internal carotid artery, and/or direct stalk injury. Clinicians should be alerted to the possibility of hypopituitarism from direct or indirect cranial injuries.
D000324:Adrenocorticotropic Hormone / Q000172:deficiency; D000328:Adult; D006259:Craniocerebral Trauma / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000172:deficiency; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007986:Luteinizing Hormone / Q000172:deficiency; D010902:Pituitary Gland / Q000293:injuries*; D011388:Prolactin / Q000378:metabolism
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone