[Differentiation of haemopoietic tissues from embryos and adults injected into irradiated chickens (author's transl)].
Irradiated chicken are injected with haemopoietic tissues from adult or 11-day-old embryos. Development of stem cells gives rise to well-defined erythrocytic colonies on the surface of the tibial marrow. Erythropoietic production appears to be similar from adult marrow and embryonic blood stem cells; production from injected vitelline stem cells seems to be between 3 and 4 times higher than that of adult marrow stem cells. Results are discussed on the basis of two hypotheses: -existence of an extramedullary erythropoietic site in the host after vitelline cells grafting; -development of vitelline stem cells in the host marrow with kinetic patterns different from those of grafted adult marrow or embryonic blood stem cells. Anyway, the 11-day-old embryo appears to contain at least two types of blood stem cells with distinctive properties. Developmental origin, relationship and future of these different stem cells remain to be analysed.
D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D002645:Chickens; D004912:Erythrocytes / Q000502:physiology; D004920:Erythropoiesis / Q000528:radiation effects; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006413:Hematopoietic System / Q000196:embryology*; D011830:Radiation Effects; D013977:Tibia / Q000196:embryology; D014184:Transplantation, Homologous; D014817:Vitelline Membrane / Q000502:physiology
Potentialites hématopoïétiques de tissus embryonnaires et adultes analysees par greffe à des poussins irradiés