The effect of vitamin E on NO2 induced redox changes in the human erythrocyte.
Human erythrocytes admixed with vitamin E supplements (50 mug/ml) were exposed to NO2 in concentrations of 200-600 p.p.m. at 37 degrees C for 2 h.  No protective effect against the increase in the redox ratio [NAD+]/[NADH]normally produced by NO2 was observed.  It is postulated that NO2 increases the redox ratio by a mechanism independent of that producing hemolysis and prevented by vitamin E.  This may involve alteration of NADH dependent enzymes by NO2.
D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009569:Nitric Oxide / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen; D010313:Partial Pressure; D011773:Pyruvates / Q000378:metabolism; D013268:Stimulation, Chemical; D014810:Vitamin E / Q000494:pharmacology*
D007773:Lactates; D011773:Pyruvates; D009243:NAD; D014810:Vitamin E; D009569:Nitric Oxide; D010100:Oxygen