Transformation of morphine by resting cells and cell-free systems of Arthrobacter sp.
Morphine can be transformed into 14-hydroxymorphine and a related unidentified material by resting cells of an Arthrobacter species. Cell-free extracts containing the transforming enzyme(s) have been obtained. O2, Fe2+, and reduced nicotinamide adenine dinucleotide stimulate the transformation.
D000693:Anaerobiosis; D001173:Arthrobacter / Q000201:enzymology*; D003300:Copper / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D008982:Molybdenum / Q000494:pharmacology; D009020:Morphine / Q000378:metabolism*; D009022:Morphine Derivatives / Q000378:metabolism*; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D013268:Stimulation, Chemical; D015032:Zinc / Q000494:pharmacology
D009022:Morphine Derivatives; D009243:NAD; D008345:Manganese; D009249:NADP; D009020:Morphine; D003300:Copper; D008982:Molybdenum; D004492:Edetic Acid; D007501:Iron; D008274:Magnesium; D015032:Zinc; D010100:Oxygen