Photoinactivation of the encephalomyocarditis virus.
Encephalomyocarditis virus was photoinactivated by a dilution of 1:30,000 neutral red and 70 minutes exposure to light. A dye inactivation of the EMC virus is possible without destruction of its antigenicity. The EMC virus vaccine induced a good immunity response in mice; we did not find any infectious virus.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D004686:Encephalomyocarditis virus / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D006387:Hemagglutination, Viral; D008027:Light; D051379:Mice; D009499:Neutral Red / Q000494:pharmacology*; D010619:Phenazines / Q000494:pharmacology*; D014765:Viral Vaccines; D014779:Virus Replication
D000914:Antibodies, Viral; D000956:Antigens, Viral; D010619:Phenazines; D014765:Viral Vaccines; D009499:Neutral Red