Lipid and lipopolysaccharide composition of Escherichia coli surface-altered mutants selected for resistance to levallorphan, tetracaine, and polymyxin.
Certain mutants of Escherichia coli with an altered permeability barrier have an essentially normal lipopolysaccharide, fatty acid, and phospholipid content, with a slight increase in the membrane protein:lipid ratio. The phospholipid metabolism of the lev and tec strains shows an abnormal response to growth in the selective agents levallorphan and tetracaine, respectively.
D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D007977:Levallorphan / Q000494:pharmacology*; D050356:Lipid Metabolism; D008070:Lipopolysaccharides / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D009154:Mutation; D010743:Phospholipids / Q000378:metabolism; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D013748:Tetracaine / Q000494:pharmacology*
D008070:Lipopolysaccharides; D008563:Membrane Lipids; D010743:Phospholipids; D011113:Polymyxins; D013748:Tetracaine; D007977:Levallorphan; D011112:Polymyxin B