High-density lipoprotein cholesterol. Significant bias between methods.
Cholesterol content of the high-density lipoproteins has become of interest in evaluating the risk of development of coronary heart disease. There is an inverse relationship between high-density lipoprotein cholesterol and risk. The authors found a significant bias (11.1 mg/dl; 0.289 mmol/l) in a comparison of a rapid cholesterol oxidase method and the Abell--Kendall method for quantitating high-density lipoprotein cholesterol. The two methods did not differ in the usual range of total serum cholesterol. Since methodology may vary, each laboratory's performance should be assessed prior to use of published risk factor data. The authors then studied normal male and female volunteers aged 20 to 35 years. They conclude that high-density lipoprotein cholesterol is of value as a risk factor indicator in this age group. The relationship of total serum cholesterol to high-density lipoprotein cholesterol was studied. The authors conclude that they are independent indicators. Further, there is a range of efficiency of the high-density lipoprotein lipid-clearing function. Finally, the authors attempted unsuccessfully to predict high-density lipoprotein cholesterol from lipoprotein electrophoresis patterns.
D000328:Adult; D002621:Chemistry / Q000379:methods; D002784:Cholesterol / Q000097:blood*; D004796:Clinical Enzyme Tests; D004586:Electrophoresis; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male
D008075:Lipoproteins, HDL; D002784:Cholesterol