title: Prolonged survival in chronic lymphocytic leukemia: a case report.
abstract: A patient with long-standing chronic lymphocytic leukemia with both humoral and cellular immunodeficiency had lymph node receptor evidence of a B lymphocyte disorder. He was also found to secrete the Epstein--Barr virus and, late in his illness, developed a markedly positive antinuclear antibody. Interrelationship of these findings may be important in the ultimate determination of the etiology and functional mechanisms in lymphocyte malignancies.
mesh_terms: D000328:Adult; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007945:Leukemia, Lymphoid / Q000097:blood / Q000150:complications / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D009422:Nervous System Diseases / Q000150:complications; D012878:Skin Neoplasms / Q000209:etiology; D013997:Time Factors