Effect of disulfiram and sodium diethyldithiocarbamate on tyrosine and dopamine-beta-hydroxylases activities in rat brain and heart.
Tyrosine hydroxylase and dopamine (DA)-beta-hydroxylase activities in rat brain and heart after disulfiram (DS) or diethyldithiocarbamate (DDC) administration have been determined in vitro and in vivo. DS and DDC in vitro stronger inhibit DA-beta-hydroxylase than tyrosine hydroxylase activity. 50% inhibition of tyrosine hydroxylase activity needed about twice higher concentrations of DS and DDC than the same inhibition of DA-beta-hydroxylase. Inhibition of the above enzymes in the in vivo experiments was DS or DDC dose dependent.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D004221:Disulfiram / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*
D013859:Thiocarbamates; D004050:Ditiocarb; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D004221:Disulfiram