Metabolism of tolmetin in rat, monkey, and man.
5-p-Carboxybenzoyl-1-methylpyrrole-2-acetic acid has been identified in the rat, monkey, and man as the major urinary metabolite of tolmetin, a new nonsteroidal anti-inflammatory agent. Conjugation of tolmetin, a major mode of disposition in man and monkey, was not observed in the rat.
D000818:Animals; D002855:Chromatography, Thin Layer; D005260:Female; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D011485:Protein Binding; D011758:Pyrroles / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity; D014046:Tolmetin / Q000378:metabolism*
D011758:Pyrroles; D014046:Tolmetin