Effect of cromolyn sodium and of daily exposure to compound 48/80 on experimental asthma.
Guinea pigs were exposed to aerosols of histamine or the mast cell degranulating and histamine releasing substance 48/80. Cromolyn sodium aerosols prevented 48/80 induced asthma but did not influence histamine induced broncho-constriction. 48/80 given daily for 5 days resulted in marked decrease in susceptibility to 48/80, possibly because of depletion of histamine and other active substances. There was no change in histamine sensitivity. After 3 days of rest, normal susceptibility to 48/80 returned.
D000336:Aerosols; D000818:Animals; D001249:Asthma / Q000139:chemically induced*; D001980:Bronchi / Q000187:drug effects; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D013997:Time Factors; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D000336:Aerosols; D006634:Histamine H1 Antagonists; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D004205:Cromolyn Sodium