[Addition of gentamicine to polymethyl methacrylate for therapy of infectious bone diseases. Expeimental in vivo tests].
In experimental  in vivo tests the therapeutic effect of Gentamicin added to Palacos is detected in a standardized osteomyelitic infection caused by Staph. aureus haemolyticus. The number of germ populations is reduced significantly by the antibiotic which is released in a microbiologically active concentration. On the other hand the number of germ populations in control trials (without adding an antibiotic) is remaining on a high level. During the time of the tests the appearance of other bacterial is registrated.
D000818:Animals; D001178:Arthroplasty; D001843:Bone Cements; D001842:Bone and Bones / Q000382:microbiology; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000302:isolation & purification; D005839:Gentamicins / Q000627:therapeutic use*; D008768:Methylmethacrylates; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000517:prevention & control; D013552:Swine
D001843:Bone Cements; D005839:Gentamicins; D008768:Methylmethacrylates
Gentamycinzusatz zum  Polymethylmethacrylat zur Behandlung von Knocheinfektionen