Antiviral action of benzo[de]isoquinoline-1,3-diones: 5-nitro-2-(2-dimethylaminoethyl) and 5-nitro-2-[2-(1-pyrrolidine)-ethyl] derivatives.
Two benzo[de]isoquinoline-diones, namely 5-nitro-2-(2-dimethylaminoethyl)-benzo[de]isoquinoline-1,3-dione and 5-nitro-2-[2-(1-pyrrolidine)-ethyl]-benzo[de]isoquinoline-1,3-dione, caused inhibition of the viral replication, when assayed against herpes simplex and vaccinia viruses in chick embryo cell cultures. Influenza and Sindbis virus replication were unaffected by these chemicals. Virucidal effects were unobserved. The inhibitory activity is time-related. Ocular and dermal infections with vaccinia virus in rabbits were prevented or disease severity reduced whenever they were treated with either one of these two drugs.
D000818:Animals; D000998:Antiviral Agents; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D005128:Eye Diseases / Q000188:drug therapy; D009980:Influenza A virus / Q000187:drug effects; D007546:Isoquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects; D012845:Sindbis Virus / Q000187:drug effects; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D013997:Time Factors; D014615:Vaccinia / Q000188:drug therapy; D014616:Vaccinia virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007546:Isoquinolines