[Participation of thyroxine in the regulation of the rate of isocitrate dehydrogenase reactions in the brain and liver].
A study was made of the effect of thyroxin on the activity of NAD- and NADP-dependent isocitratedehydrogenases in the brain and the liver of chick embryos. It was found that in both of the organs thyroxin accelerated isocitrate oxidation in the mitochondria through the NAD-dependent route and elevated the velocity of the NADP-isocitratedehydrogenase reaction in the citoplasm. At the same time the activity of the mitochondrial NADP-dependent isocitratedehydrogenase increased after the administration of the hormone to the embryos only in the mitochondria of the brain cells; this was apparently associated with the intensive biosynthesis of specific lipids in the developing brain. There was noted a more marked change in the activity of the enzymes in the 18-day embryos, in comparison with the 12-day ones.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D002642:Chick Embryo; D003593:Cytoplasm / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*
D008055:Lipids; D009243:NAD; D009249:NADP; D007521:Isocitrate Dehydrogenase; D013974:Thyroxine
Uchaste tiroksina v reguliatsii skorosti izotsitratdegidrogenaznoĭ REAKTSII v mozge i pecheni