title: Low dose fluphenazine decanoate in maintenance treatment of schizophrenia.
abstract: To test the clinical efficacy of low dose fluphenazine decanoate (1.25 mg to 5.0 mg biweekly), we carried out two separate experiments: (1) an open trial in 57 schizophrenic outpatients, lasting 6 months; (2) a double-blind, placebo-controlled discontinuation study in a subgroup of patients who maintained good remission throughout the entire 6-month open trial. The results suggest that lower doses of fluphenazine decanoate than those usually used may be effective in preventing psychotic relapse while keeping total cumulative dosage to a minimum.
mesh_terms: D000359:Aftercare; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005476:Fluphenazine / Q000627:therapeutic use*; D006801:Humans; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D005476:Fluphenazine