Treatment of porcine malignant hyperthermia. A review based on experimental studies.
The metabolic and endocrine changes in porcine malignant hyperthermia are described and the importance of the catecholamine response emphasised. The relative effectiveness of several different therapeutic agents in the treatment of this syndrome in the Pietrain pig are described and the importance of a common link with the catecholamine response discussed.
D000818:Animals; D001786:Blood Glucose; D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood; D002395:Catecholamines / Q000097:blood; D002746:Chlorpromazine / Q000627:therapeutic use; D003620:Dantrolene / Q000627:therapeutic use; D004562:Electrocardiography; D006221:Halothane; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000627:therapeutic use; D008305:Malignant Hyperthermia / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D009127:Muscle Rigidity / Q000150:complications; D010646:Phentolamine / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011342:Procainamide / Q000627:therapeutic use; D011343:Procaine / Q000627:therapeutic use; D013390:Succinylcholine; D013552:Swine; D014284:Triiodothyronine / Q000627:therapeutic use
D001786:Blood Glucose; D002395:Catecholamines; D014284:Triiodothyronine; D002245:Carbon Dioxide; D011343:Procaine; D003620:Dantrolene; D008274:Magnesium; D013390:Succinylcholine; D011342:Procainamide; D011188:Potassium; D002746:Chlorpromazine; D006221:Halothane; D010646:Phentolamine