Alterations of adrenal and uterine angiotensin II receptors during variation of sodium intake and/or experimental hypertension.
1. Angiotensin II receptors from rat adrenal gland and myometrium were studied during variation of sodium intake. 2. In both target-tissues low Na+ diet increased the number of receptors whereas a high Na+ diet did not modify the adrenocortical receptors but increased the number of uterine receptors. 3. Deoxycorticosterone and one kidney Goldblatt hypertension were associated with a decrease in the number of adrenal receptors. 4. Alterations of angiotensin II receptors alone cannot explain satisfactorily the variations of sensitivity of target-cells to angiotensin II during sodium balance changes.
D000311:Adrenal Glands / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D003900:Desoxycorticosterone; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism; D051381:Rats; D011945:Receptors, Angiotensin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012083:Renin / Q000097:blood; D012965:Sodium Chloride; D014599:Uterus / Q000378:metabolism*
D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D000804:Angiotensin II; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D012083:Renin