[Effect of creatine phosphate on the slow inward calcium current, action potentials and the strength of myocardial contraction].
The effect of creatine phosphate on the frog heart muscle involved maintenance of its contraction at high level even after inhibition of mitochondrial oxidative phosphorylation by sodium cyanide. The effect of creatine phosphate on the contractile force and action potential is similar for the frog heart ventricle and atrium. The voltage--clamp technique showed that creatine phosphate controlled the slow inward calcium current through the surface membrane of the frog atrium cells.
D000200:Action Potentials / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000032:analysis; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis / Q000494:pharmacology*; D011898:Ranidae
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D002118:Calcium
Vliianie kreatinfosfata na medlennyĭ vnutr' napravlennyĭ kal'tsievyĭ tok, potentsial deĭstviia i silu sokrashcheniia miokarda.