title: ACTH 4-10 in the amelioration of neuropsychological symptomatology associated with senile organic brain syndrome.
abstract: Eighteen male and female volunteers over the age of sixty who exhibited mild senile organic brain syndrome were administered ACTH 4-10 (Org OI 63) (30 mg, s.c.) or saline in a 2 X 2 Latin square design. Subjects experienced a reduction in depression and confusion and an increase in vigor. This evidence of an increase in vigor was supported behaviorally by a delay in the onset of increased latency in reaction time. Data also indicated that retrieval from memory may be enhanced by this compound. The electroencephalogram evinced a shift to lower frequencies under ACTH 4-10, but this effect was primarily noted in the females who received drug followed by placebo. These effects of ACTH 4-10 are intriguing and suggest that further work in this area should be encouraged.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000368:Aged; D002986:Clinical Trials as Topic; D003704:Dementia / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004569:Electroencephalography; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use; D010465:Perception / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone