[Oxidation of erucic acid and erucyl-CoA by isolated rat heart mitochondria: comparison to oleic acid].
The oxidation of [14 14-C] or [1 14-C] erucic acid by isolated mitochondria from Rat heart has been studied and compared with that of [10 14-C] oleic acid in varying conditions of incubation. Erucic acid is converted to CO2 and acid-soluble compounds much more slowly than oleic acid. The acid-soluble compounds which have been identified are acylcarnitines, ketone bodies and intermediates from the Krebs cycle; they are found in similar proportions for both substrates. Moreover, the oxidation rate of erucyl-CoA is comparable, if not equal, to that of oleyl-CoA in the same conditions. These results are discussed here. They lead to the conclusion that erucic acid is oxidized by isolated Rat heart mitochondria through the beta oxidation pathway, and that its oxidation is limited owing to its slow activation rate.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002331:Carnitine / Q000031:analogs & derivatives / Q000378:metabolism; D002952:Citric Acid Cycle; D003065:Coenzyme A / Q000378:metabolism*; D004883:Erucic Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009206:Myocardium / Q000648:ultrastructure; D009829:Oleic Acids / Q000378:metabolism*; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D012995:Solubility; D013386:Succinates / Q000378:metabolism
D004883:Erucic Acids; D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; D013386:Succinates; D002245:Carbon Dioxide; D002331:Carnitine; D003065:Coenzyme A
Oxydation de l'acide érucique et de l'érucyl-CoA par les mitochondries isolées de coeur de rat: comparaison à l'acide oléique