Apparent posttranscriptional block to anaerobic induction of endogenous leukemia virus.
Uninfected Fischer rat cells were induced by anaerobic stress to transcribe high levels of endogenous type C leukemia virus RNA. Complete 35S virus RNA with attached polyadenylic acid sequences was found associated with polysomes, indicating functional mRNA. Since no mature virus was released under these conditions, the presence of a posttranscriptional block to complete virus synthesis is strongly indicated.
D000693:Anaerobiosis; D000818:Animals; D002460:Cell Line; D011132:Polyribosomes / Q000378:metabolism; D012367:RNA, Viral / Q000096:biosynthesis*; D051381:Rats; D012190:Retroviridae / Q000254:growth & development / Q000378:metabolism*; D014158:Transcription, Genetic; D014779:Virus Replication
D012367:RNA, Viral