Maternal immunization to paternal antigens in multiparous mice.
Mice of the CBA strain which had given birth to five litters sired by males of a different H-2 type (C57BL/10) showed evidence of immunization to paternal antigens, in that the numbers of lymphocytes forming alloclusters with paternal erythrocytes were significantly elevated. On the other hand, the graft-versus-host responsiveness of maternal splenic lymphocytes to paternal antigens remained virtually unchanged, showing only a slight increase at Day 8 of the assay.
D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010298:Parity; D011247:Pregnancy; D011270:Pregnancy, Animal; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D006649:Histocompatibility Antigens