Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis.
Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditis.
D000818:Animals; D000831:Animals, Newborn; D003384:Coxsackievirus Infections / Q000150:complications* / Q000473:pathology; D029822:Enterovirus B, Human; D006322:Heart Aneurysm / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009205:Myocarditis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D009206:Myocardium / Q000473:pathology