title: Evidence for a role of alpha-adrenergic mechanisms in regulation of episodic growth hormone secretion in the rat.
abstract: The role of catecholamines in regulation of episodic GH secretion was investigated in the male rat. Administration of alpha-methyl-p-tyrosine (alpha-MT; 250 mg/kg ip) caused significant suppression of GH bursts and resulted in marked elevation of plasma PRL. Intravenous administration of apomorphine (.03 and .1 mg/kg) had no effect on decreased GH levels, whereas clonidine (150 micrograms/kg) restored GH secretion. Apomorphine significantly reduced PRL levels in alpha-MT-treated rats whereas, clonidine resulted in a further increase in PRL.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D010507:Periodicity; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
chemical_list: D008781:Methyltyrosines; D011942:Receptors, Adrenergic, alpha; D011388:Prolactin; D013006:Growth Hormone; D003000:Clonidine; D001058:Apomorphine