title: A comparative study of the two alternative larval forms of Hymenolepis nana, the dwarf tapeworm, with special reference to the process of excystment.
abstract: Studies of the cysticercoids of Hymenolepis nana from insects and from mouse villi revealed important differences in cyst structure and function. The insect form resists low pH unless treated with bile salts which render the cyst permeable and reduce infectivity to mice. Bile salts are not essential for scolex activation. Activation is inhibited by pH 2.5 and under and by 1% succinic acid up to pH 4.0. The importance of scolex immobility and energy conservation in relation to cyst impermeability is discussed. The villus cysticercoid has no special insulating layer. It is vulnerable to low pH and cannot infect mice orally. Bile salts are without effect and excystment occurs unaided by external agents. The structural differences between the two forms revealed by the electron microscope may be attributed to changes in the relative rates of development of the various tissues.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D002462:Cell Membrane / Q000648:ultrastructure; D002589:Cestoda / Q000196:embryology*; D003238:Connective Tissue / Q000648:ultrastructure; D006863:Hydrogen-Ion Concentration; D006926:Hymenolepis / Q000187:drug effects / Q000196:embryology* / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000648:ultrastructure; D007773:Lactates / Q000494:pharmacology; D007814:Larva; D051379:Mice / Q000469:parasitology*; D009130:Muscle, Smooth / Q000648:ultrastructure; D013270:Stomach / Q000469:parasitology; D013386:Succinates / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology; D014231:Tribolium / Q000469:parasitology*
chemical_list: D001647:Bile Acids and Salts; D007773:Lactates; D013386:Succinates; D013501:Surface-Active Agents