Localization of ACTH in the human hypothalamus.
Using an antiserum to porcine ACTH and the unlabeled antibody preoxidase-antiperoxidase technique, we have found that ACTH is present in neuronal cell bodies located exclusively in the arcuate nucleus of the human hypothalamus. ACTH-containing fibers are distributed extensively throughout the hypothalamus with a greatest density in the periventricular nucleus. No concentration of ACTH fibers could be observed in the neurovascular zone of the pituitary stalk.
D000324:Adrenocorticotropic Hormone / Q000302:isolation & purification*; D000368:Aged; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007031:Hypothalamus / Q000032:analysis*; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000032:analysis
D000324:Adrenocorticotropic Hormone