Comparative studies of five heat-labile toxic products of Escherichia coli.
Five heat-labile, partially purified toxic products of Escherichia coli were distinguished by isoelectric focusing, molecular weight, and neutralization with homologous and heterologous antisera. Only two affected the morphology of Y-1 cells, induced fluid accumulation in rabbit ileal loops, and stimulated production of cyclic AMP in Vero cells; these two did not cross-neutralize and only one showed cross-neutralization with cholera antitoxin. The remaining three products were cytotoxic for Vero cells.
D001427:Bacterial Toxins / Q000032:analysis / Q000096:biosynthesis; D001834:Body Water / Q000378:metabolism; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D004768:Enterotoxins / Q000032:analysis / Q000096:biosynthesis; D004926:Escherichia coli / Q000032:analysis* / Q000378:metabolism; D006358:Hot Temperature; D007526:Isoelectric Point; D009500:Neutralization Tests
D001427:Bacterial Toxins; D004768:Enterotoxins; D000242:Cyclic AMP