[5-Bromodeoxyuridine inhibition of the transformation of Rous sarcoma virus-infected chicken cells].
The transformation of Rous-Sarcoma-Virus-infected synchronized Chicken cells is prevented when 5-bromodeoxyuridine is added for 3 hrs. at time of the peak of the first S phase following infection. Virus progeny is normally released. The inhibitory effect of BrdU is reversed by simultaneous addition of thymidine, but not by that of deoxyuridine. Hence, the inhibition of the transformation seems to result from the incorporation of the analogue into the nuclear DNA.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000502:physiology*; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts; D007700:Kinetics; D008938:Mitosis / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D001973:Bromodeoxyuridine
Inhibition par la 5-bromodésoxyuridine, de la transformation des cellules de poule infectées par le virus de Rous.