[Effect of cocarboxylase on hyperlactatemia and hyperpyruvicemia induced by phenformin in dogs].
In the normal anesthetized dog, a cocarboxylase perfusion considerably reduced the increase in blood lactate and pyruvate levels provoked by the intraduodenal injection of phenformin (30 mg/kg); furthermore it seems to counteract the increase of the lactates/pyruvates ratio and opposes the fall in blood pH.
D000818:Animals; D001769:Blood; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D010629:Phenformin / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*
D007773:Lactates; D011773:Pyruvates; D010629:Phenformin; D013835:Thiamine Pyrophosphate
Effet de la cocarboxylase sur l'hyperlactatémie et l'hyperpyruvicémie provoquées par la phenformine chez le chien