A lymphoblastoid cell line from an adenosine deaminase deficient patient established by Epstein-Barr virus.
Lymphoblastoid cell lines from a patient with adenosine deaminase (ADA) deficiency and his parents were established by Epstein-Barr virus (EBV). ADA activity in the lymphoblastoid cells from the patient was not detectable, while the enzyme activity in the cells from his parents was approximately a half level of the controls'. No inhibitor to ADA could be detected in the lymphoblastoid cells from the patient.
D000243:Adenosine Deaminase / Q000172:deficiency*; D002460:Cell Line; D002472:Cell Transformation, Viral; D004854:Herpesvirus 4, Human; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology; D007223:Infant; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology; D008297:Male; D009700:Nucleoside Deaminases / Q000172:deficiency*
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase