Imbalance in the activities of alkaline phosphatase and Na+-K+-ATPase in the brain of experimentally induced phenylketonuric squirrels (Funambulus palmarum).
Phenylketonuric squirrels have shown marked inhibition of alkaline phosphatase in the olfactory lobes and cerebral hemispheres, whereas the Na+-K+-ATPase remained less altered. In the pathogenesis of phenylketonuria inhibition of alkaline phosphatase at the level of "Blood-Brain Barrier" (BBB), leads transport system to impaired functioning.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D006801:Humans; D009830:Olfactory Bulb / Q000201:enzymology; D010649:Phenylalanine / Q000494:pharmacology; D010661:Phenylketonurias / Q000139:chemically induced / Q000201:enzymology*; D012589:Sciuridae / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010649:Phenylalanine; D000469:Alkaline Phosphatase; D000254:Sodium-Potassium-Exchanging ATPase