Association of lysolecithin acyltransferase with the high density lipoproteins and its activation by the low density lipoproteins in normal human plasma.
The lysolecithin acyltransferase of human plasma is shown to be associated with the high-density lipoprotein fraction. Although the low density lipoproteins do not have intrinsic enzyme activity, their presence activated the enzyme 3--7-fold. This activation is not affected by heat-treatment of the low density lipoproteins, but is abolished by the addition of heparin.
D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000097:blood*; D000217:Acyltransferases / Q000097:blood*; D000328:Adult; D004789:Enzyme Activation / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D006493:Heparin; D000217:Acyltransferases; D008243:1-Acylglycerophosphocholine O-Acyltransferase