title: [Passive protection tests in the mouse with pertussis immunoglobulin (author's transl)].
abstract: A reproducible method for potency-testing of pertussis-sera and - immunoglobulines in a neutralisation test in the mouse is described. The tests were done on two human immunoglobulines, one crude immune serum from the rabbit, and two purified resp. concentrated rabbit immune sera, one of which - the US-Standard for Pertussis Sera - was used as the standard preparation for the potency evaluation. There is no correlation between the results of the neutralisation test and the agglutination titer among the different preparations. That means, the agglutination titer is not suitable for comparing the potency of pertussis sera resp. - immunoglobulines. It seems necessary to establish a uniforme method as well as a standard preparation for potency testing of pertussis sera and - immunoglobulines on the basis of the neutralisation test in the mouse - at least on the European level.
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology; D007136:Immunoglobulins / Q000592:standards / Q000627:therapeutic use; D051379:Mice; D009500:Neutralization Tests; D010567:Pertussis Vaccine / Q000627:therapeutic use*; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D007136:Immunoglobulins; D010567:Pertussis Vaccine
vernacular_title: Passive Mäuseschutzversuche mit Pertussis-Immunglobulin.