title: Studies on the mode of action of IME--an inhibitor of interferon activity from mouse embryo tissues.
abstract: IME--inhibitor of interferon activity from mouse embryo tissues does not inactive interferon by direct contact; it does not inhibit the production of interferon and it does not affect the replication of challenge virus. IME shows no species-specific activity since it exhibits anti-interferon action not only in homologous interferon system but also in the heterologous rat, chick and human interferon systems. The interferon-induced antiviral state as well as the efficient cell's metabolism appear to be necessary for the expression of activity of IME.
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000276:immunology / Q000382:microbiology; D004686:Encephalomyocarditis virus / Q000254:growth & development; D007372:Interferons / Q000037:antagonists & inhibitors*; D007739:L Cells; D051379:Mice; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
chemical_list: D007372:Interferons