Experimental salicylate intoxication in young baboons. A preliminary report.
Salicylate intoxication has been investigated in young baboons. The results of these studies are similar to these previously obtained in man. Acidosis appears to be of considerable importance in the pathogenesis of infantile salicylism as it enhances the passage of salicylate into the CSF. The CSF concentration of salicylate seems to be of major physiologic importance in this condition. Moreover, the serum concentration of free salicylate correlates more closely with the CSF concentration of salicylate than does the total serum concentration of salicylate.
D000136:Acid-Base Equilibrium; D000142:Acidosis, Respiratory / Q000139:chemically induced / Q000150:complications; D000472:Alkalosis, Respiratory / Q000139:chemically induced; D000643:Ammonium Chloride; D000818:Animals; D001241:Aspirin / Q000097:blood / Q000134:cerebrospinal fluid / Q000633:toxicity; D001639:Bicarbonates / Q000097:blood; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D000882:Haplorhini; D006863:Hydrogen-Ion Concentration; D008526:Medulla Oblongata / Q000187:drug effects; D010215:Papio; D010539:Permeability; D011485:Protein Binding; D012459:Salicylates / Q000097:blood / Q000134:cerebrospinal fluid / Q000633:toxicity*; D012709:Serum Albumin / Q000378:metabolism
D001639:Bicarbonates; D012459:Salicylates; D012709:Serum Albumin; D000643:Ammonium Chloride; D002245:Carbon Dioxide; D001241:Aspirin