title: Feedback-controlled dextrose infusion during surgical management of insulinomas.
abstract: Through the use of a feedback-controlled dextrose infusion system, we obtained continuous monitoring of the blood glucose level in a patient undergoing surgery for multiple pancreatic beta-cell tumors. In addition, this device infused dextrose at variable rates to maintain a predetermined euglycemic level of 90 mg/dl. Before locating the source of excessive insulin production, the maximum dextrose infusion rate of 400 mg/min was required; but after extirpation of multiple insulinomas, the dextrose-infusion rate declined whereas the blood glucose level rose above the preselected level. These results emphasize the usefulness of a monitoring and infusion system not only in protecting the patient from the hazard of hypoglycemia under anesthesia but also as an aid in determining whether all insulin-secreting tumors have been removed.
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis / Q000601:surgery*; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D005246:Feedback; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D008991:Monitoring, Physiologic / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000601:surgery*
chemical_list: D001786:Blood Glucose; D005947:Glucose