Replication of herpes simplex virus in human B lymphocytes stimulated by Epstein-Barr virus.
Human B lymphocytes prepared from adult blood or cord blood by the use of neuraminidase-treated sheep red blood cells which did not respond mitogenically to phytohemagglutinin or pokeweed mitogen, responded well to the B95-8 strain of Epstein-Barr virus, but not to the P3HR-1 strain, with increased incorporation of tritiated thymidine. Replication of herpes simplex virus could be demonstrated in cultures of B lymphocytes preincubated with the B95-8 strain.
D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000382:microbiology*; D001773:Blood Cells; D005312:Fetal Blood / Q000166:cytology; D004854:Herpesvirus 4, Human / Q000254:growth & development; D006801:Humans; D008213:Lymphocyte Activation; D008934:Mitogens; D018139:Simplexvirus / Q000254:growth & development*; D014779:Virus Replication
D008934:Mitogens