[Inhibitory effect of cerebrospinal fluid on the activity of sodium-, potassium-ATPase in animal brain synaptic membranes].
Liquor cerebrospinalis, obtained from patients with various diseases, inhibited Na, K-ATPase from rat and bovine synaptic membranes and did not influence on the activity of Mg-ATPase. The inhibition was independent on the type of disease. The inhibitory effect of liquor cerebrospinalis disappeared after dyalisis of it against Krebs-Ringer solution. Liquor cerebrospinalis appears to contain an endogenous inhibitor of synaptic Na,K-ATPase, which controls the enzymatic activity in vivo.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D001930:Brain Injuries / Q000134:cerebrospinal fluid; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid; D002417:Cattle; D002555:Cerebrospinal Fluid; D006501:Hepatic Encephalopathy / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid; D066298:In Vitro Techniques; D009437:Neuralgia / Q000134:cerebrospinal fluid; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013570:Synaptic Membranes / Q000201:enzymology*; D000160:Vestibulocochlear Nerve Diseases / Q000134:cerebrospinal fluid
D000254:Sodium-Potassium-Exchanging ATPase
Ingibiruiushchee vliianie likvora na aktivnost' natriĭ-, kaliĭ-ATF-azy sinapticheskikh membran golovnogo mozga zhivotnykh.