Pathological actin in vestibular hair cells of the waltzing guinea pig.
Vestibular type 1 hair cells in the waltzing guinea pig contain needle-shaped inclusion bodies which grow in an uncontrolled fashion associated with the destruction of the cell. The needles are shown to be composed by filaments of actin, a protein identified in the electron microscope by its ability to bind subfragment 1 of myosin. Whereas actin filaments in stereocilia are oriented down towards the cell body, filaments in the needles point up towards the cuticular plate. The hereditary lesion appears to be associated with a defective control of polymerization of actin into filaments.
D000199:Actins; D000818:Animals; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000648:ultrastructure*; D002479:Inclusion Bodies / Q000187:drug effects / Q000648:ultrastructure*; D007759:Labyrinth Diseases / Q000235:genetics / Q000473:pathology*; D011092:Polyethylene Glycols / Q000494:pharmacology
D000199:Actins; D011092:Polyethylene Glycols