title: [Changes in imipramine induced noradrenaline potentiation by varying activity of gastric juice under oral medication].
abstract: From the serial studies on imipramine dependent noradrenaline (NA) rise at different values of gastric acid with 336 registrations of blood pressure, it follows that a lawful relation exists between imipramine absorption and gastric juice acidity. At pH values of 3.5--6.0 a distinct decreased absorption of orally supplied imipramine was stated. After changing the pH value by acid substitution, a full absorption is reached. This state seems to be of special practical importance in the treatment of depression with thymoleptics.
mesh_terms: D000126:Achlorhydria; D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004357:Drug Synergism; D005750:Gastric Juice / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007099:Imipramine / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D007099:Imipramine; D009638:Norepinephrine
vernacular_title: Veränderungen der durch Imipramin bedingten Noradrenalinpotenzierung durch unterschiedliche Magensäurewerte bei oraler Medikation