Effect of briefly heating cyclophosphamide solutions.
Solutions containing cyclophosphamide monohydrate were heated to 50 C, 60 C, 70 C and 80 C for 15 minutes and then assayed for potency. Solutions heated to 50 Cor 60 C did not change appreciably; those heated to 70 C and 80 C assayed at 90.2% and 77.5%, respectively, of initial potency. The values compared well with those calculated using the Arrhenius equation. It is concluded that warming vials of cyclophosphamide monohydrate after adding an aqueous vehicle (in order to achieve rapid dissolution) could decrease the potency of the final injectable product.
D003520:Cyclophosphamide; D004355:Drug Stability; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D012996:Solutions; D013696:Temperature
D012996:Solutions; D003520:Cyclophosphamide