Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation.
A correlation was found between inhibition of protein methylase I and inhibition of virus-induced cell transformation by structural analogs of S-adenosylhomocysteine; all good inhibitors of this enzyme are also good inhibitors of Rous sarcoma virus-induced chicke embryo fibroblast transformation. The inhibitory effect of these analogs was similar on enzymes from normal and transformed cells; no significant variation of the inhibition constants was observed after purification of protein methylase I. From the kinetic constants obtained, a structure-activity relationship can be established for protein methylase I.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts; D006710:Homocysteine / Q000031:analogs & derivatives*; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors*; D011484:Protein-Arginine N-Methyltransferases / Q000037:antagonists & inhibitors*; D012435:S-Adenosylhomocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006710:Homocysteine; D012435:S-Adenosylhomocysteine; D011496:Protein Methyltransferases; D011484:Protein-Arginine N-Methyltransferases