Overnight sleep EEG and cerebrospinal fluid monoamines in seizures induced by movement.
Clinical, electrical and biochemical studies in an eight years old boy with movement-induced seizures were reported. The attack was usually triggered by sudden initiation of movement, but rarely occurred without any apparent movement. Repeated jumping provoked attacks constantly, which was recorded cinematographically. No abnormality was found either in ictal or interictal EEGs. Haloperidol aggravated the condition, but 1-DOPA had no effect, while DPH (100 mg/day) controlled attacks perfectly with the serum DPH concentration of just 2.0 ug/dl. In overnight sleep analysis, sleep rhythms and characters of REM sleep were not differed significantly from the standard. After DPH therapy, stabilization of sleep in general was noticed; that is, total sleep time prolonged, number of sleep stages decreased and interrupting awakening disappeared. Probenecid loading test revealed that 5-HIAA was normal, HVA high, and large amount of octopamine was detected in CSF.
D002648:Child; D004569:Electroencephalography; D006220:Haloperidol / Q000627:therapeutic use; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D009068:Movement; D010375:Pedigree; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000134:cerebrospinal fluid* / Q000235:genetics; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology
D010648:Phenylacetates; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D010672:Phenytoin; D006220:Haloperidol; D006719:Homovanillic Acid