title: [Immunization effectiveness of the inactivated vaccine against infectious bovine rhinotracheitis (IBR) with an oily adjuvant].
abstract: The adjuvant vaccine against infectious bovine rhinotracheitis (IBR) was tested as to its innocuousness and immunogenicity. The immunity response induced by a single or double application of different vaccine doses was evaluated according to the content of neutralization antibodies (NP) in the blood serum. A direct dependence was revealed between the size of the inoculum and NP content in the blood serum, with NP titres of 1 : 9.3; 1 : 26.6, 1 : 80 and 1 : 149 after doubled application of 1, 2, 5, and 10 ml of the vaccine. The calves inoculated at an age of one week produced antibodies in the same titres as one- to five-month-old calves. Singly inoculated animals mostly showed zero-level or low antibody titres, but revaccination induced general serum-positivity with NP titres 1 : 4 to 1 : 128. The animals which had been in contact with the IBR virus and were serologically negative during inoculation or had an NP content in the blood serum at a titre of 1 : 4 or less, gave an anamnestic response to inoculation, but revaccination did not lead to a significant rise in antibody content. Double administration of 2 ml of vaccine in four production charges induced the production of antibodies with average titres of 1 : 36, 1 : 25; 1 : 31 and 1 : 24. Inoculation of susceptible animals in non-infected herds and of clinically healthy animals in infected herds did not cause any health disorders. IBR; inactivated adjuvant vaccine; different age; different doses; immunity response; neutralization antibodies.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D002417:Cattle; D007242:Herpesvirus 1, Bovine / Q000276:immunology; D007241:Infectious Bovine Rhinotracheitis / Q000276:immunology / Q000517:prevention & control*; D009821:Oils; D014611:Vaccination; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000592:standards*
chemical_list: D000276:Adjuvants, Immunologic; D009821:Oils; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
vernacular_title: Imunizacná úcinnost inaktivovanej vakcíny proti infekcnej bovínnej rinotracheitíde (IBR) s olejovým adjuvans.