Recovery of three distinct biologically active type C viruses from cloned C57Bl/6 melanoma cells.
The genome of a single cell derived from the B16 melanoma contains information for the expression of three distinct biologically active viruses: the N- and B-tropic ecotropic viruses and the xenotropic virus. Their release results in reduction of melanin production. A possible relationship of virus replication to differentiation may be involved.
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D003513:Cycloheximide / Q000494:pharmacology; D007065:Idoxuridine / Q000494:pharmacology; D009052:Leukemia Virus, Murine / Q000254:growth & development / Q000302:isolation & purification*; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000382:microbiology; D011691:Puromycin / Q000494:pharmacology; D012190:Retroviridae / Q000254:growth & development / Q000302:isolation & purification*; D014779:Virus Replication / Q000187:drug effects
D008543:Melanins; D011691:Puromycin; D003513:Cycloheximide; D007065:Idoxuridine