Postnatal activity of angiotensin converting enzyme in rat brain.
The specific activity of angiotensin converting enzyme (ACE) was studied in eight brain regions in rats 2--65 days of age. At 65 days of age the activities in various regions relative to the cortex were: neostriatum, 1,200%; hippocampus/amygdala, 430%; hypothalamus, 190%; cerebellum, 140%; and midbrain, thalamus and pons/medulla, 110%. Significant linear increases were found in the neostriatum, hippocampus/amygdala and cortex at 2--65 days of age, in the pons/medulla and thalamus at 2--42 days of age and in the midbrain at 2--21 days of age. The increase with age was greatest in the neostriatum and the data are consistent with the occurrence of ACE in neurons in this area.
D000375:Aging; D000679:Amygdala / Q000201:enzymology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D003342:Corpus Striatum / Q000201:enzymology; D006624:Hippocampus / Q000201:enzymology; D007031:Hypothalamus / Q000201:enzymology; D008636:Mesencephalon / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D013788:Thalamus / Q000201:enzymology
D007703:Peptidyl-Dipeptidase A