[Pharmacological and radioprotective properties of some gamma-pyrone derivatives (flavanones and flavanols)].
In experiments set up on mice, rats and guinea pigs 8 gamma-pyron derivatives were studied. They proved to be little toxic, do not change significantly the arterial pressure and respiration, exercise a depressing action on the central nervous system, produce a marked antiphlogistic (normal and irradiated animals), radio-protective and antihistaminic effects and influence norephinephrine, homovanillic acid and dopamine metabolism in the brain.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D012800:Siberia; D013997:Time Factors; D014197:Trees; D014934:Wood
D000893:Anti-Inflammatory Agents; D002395:Catecholamines; D005419:Flavonoids; D006634:Histamine H1 Antagonists; D010936:Plant Extracts; D011714:Pyrans; D011753:Pyrones; D011837:Radiation-Protective Agents
Farmakologicheskie i radiozashchitnye svoĭstva nekotorykh proizvodnykh gamma-pirona (flavanony i flavanoly)