title: Phosphodiesterase inhibition by succinic and related acid biphenylalkyl monoesters.
abstract: Biphenylalkyl monoesters of succinic and related acids represent a potent new class of cyclic AMP phosphodiesterase inhibitors. The biphenyl group is necessary for potent inhibition. The spatial relationship of the carboxyl and ester groups and alkyl chain length are important to inhibitory potency.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002417:Cattle; D066298:In Vitro Techniques; D007700:Kinetics; D009206:Myocardium / Q000201:enzymology; D010726:Phosphodiesterase Inhibitors; D013386:Succinates / Q000494:pharmacology*
chemical_list: D001713:Biphenyl Compounds; D010726:Phosphodiesterase Inhibitors; D013386:Succinates; D015105:3',5'-Cyclic-AMP Phosphodiesterases