[Preliminary data on the behavior of the enzyme of metabolism of phospholipid bases in human tumor preparations].
The A.A. have investigated the phospholipids base-exchange enzyme system in the solid tumours in order to state if a correlation between this activity and the variation of the cellular ciclic nucleotides amount was possible considering that these compounds have been reported to undergo a variation in tumour compared with normal tissues. They report some previous results in a lung tumour and in an endometrial carcinoma, were they have found a big increase in the PhS synthesis. Such increase was possible to be seen in the endometrial carcinoma only after a stimulation by 17-beta-estradiol and it was reversed in this case by doxorubicine. These results suggest that an alteration of the PhS synthesis should be one of numerous peculiarity of the neoplastic cell.
D000230:Adenocarcinoma / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism*; D010718:Phosphatidylserines / Q000096:biosynthesis*; D010743:Phospholipids / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism
D007093:Imidazoles; D010718:Phosphatidylserines; D010743:Phospholipids; D004958:Estradiol; D004317:Doxorubicin
Dati preliminari sul comportamento dell'enzima dello scambio delle basi fosfolipidiche in preparati di tumore umano.