Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome.
In 1967, Kawasaki, in Japan, first described a new syndrome affecting infants and young children-an acute, febrile illness with mucocutaneous involvement associated with swelling of cervical lymph nodes. The prognosis is usually good but recently it has become evident that 1-2 percent of the patients die suddenly from acute heart failure. Infantile polyarteritis (nodosa-like arteritis) accompained by coronary aneurysm and thrombosis has been noted in postmortem examinations. Twenty patients surviving the illness were examined by coronary angiography; 12 of the 20 had abnormal coronary angiograms; seven patients had coronary aneurysms. Complete regression of the coronary aneurysms was proved in two patients at subsequent angiography. One patient developed mitral regurgitation as a result of papillary muscle dysfunction. One had a coronary aneurysm without symptoms two years after the onset of illness.
D000208:Acute Disease; D000783:Aneurysm / Q000175:diagnosis / Q000209:etiology*; D000790:Angiocardiography; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D004562:Electrocardiography; D005260:Female; D005334:Fever; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000503:physiopathology; D008206:Lymphatic Diseases / Q000150:complications* / Q000401:mortality; D008297:Male; D009092:Mucous Membrane / Q000503:physiopathology; D010701:Phonocardiography; D010488:Polyarteritis Nodosa / Q000209:etiology*; D012877:Skin Manifestations / Q000503:physiopathology