Spontaneous liver tumors in aged germfree Wistar rats.
Liver tumors, ranging from benign nodules to carcinomas, developed spontaneously in 115 (87%) of 132 germfree Wistar rats beyond the age of 30 months. In addition, the rats developed a high incidence of benign adenomas of endocrine glands and of the breasts.
D000236:Adenoma / Q000662:veterinary; D000367:Age Factors; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000662:veterinary*; D004700:Endocrine System Diseases / Q000662:veterinary; D005260:Female; D005856:Germ-Free Life; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009369:Neoplasms / Q000662:veterinary; D051381:Rats; D012376:Rodent Diseases / Q000473:pathology*