Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.
Inhibitory effects of several chemicals on the mutagenicities of 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM) for Salmonella typhimurium G46 in the host-mediated assay were investigated. They were carbon disulfide (CS2), tetraethylthiuram disulfide (disulfiram, DSF), sodium diethyldithiocarbamate (SDDC), ethylene-bis(dithiocarbamato) manganese (Maneb), pyrazole (PZ), aminoacetonitrile hydrogen sulfate (AAN), and sodium selenite (SE). All the compounds, except for SE, inhibited the mutagenicities of DMH and AOM.
D000607:Aminoacetonitrile / Q000494:pharmacology; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D001397:Azoxymethane / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002246:Carbon Disulfide / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004221:Disulfiram / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008297:Male; D008344:Maneb / Q000494:pharmacology; D008763:Methylhydrazines / Q000494:pharmacology*; D051379:Mice; D009153:Mutagens; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011720:Pyrazoles / Q000494:pharmacology
D001391:Azo Compounds; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D009153:Mutagens; D011720:Pyrazoles; D008344:Maneb; D000607:Aminoacetonitrile; D004050:Ditiocarb; D001397:Azoxymethane; D002246:Carbon Disulfide; D004221:Disulfiram