title: Mixed neuromuscular block. A re-assessment using train-of-four stimulation.
abstract: Suxamethonium was administered to patients during recovery from non-depolarising muscle relaxation. The effect of suxamethonium varied depending upon the degree of recovery from the non-depolarising block when it was administered. Early in recovery suxamethonium produced reversal of the non-depolarising block without paralysis whereas when administered later, initial recovery of the non-depolarising block was followed by paralysis. If administered after 50% recovery the predominant effect was paralysis without initial recovery. Assessment of neuromuscular blockade with train-of-four stimulation showed that the paralysis produced by suxamethonium under these circumstances, had depolarising and non-depolarising features.
mesh_terms: D001285:Atropine / Q000494:pharmacology; D006801:Humans; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D010243:Paralysis; D011184:Postoperative Period; D013390:Succinylcholine / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D009388:Neostigmine; D001285:Atropine; D013390:Succinylcholine