A comparison of the effects of PGI2, PGE2 and PGH2 on the cyclic nucleotide levels in rat anterior pituitary gland in vitro.
Rat anterior pituitary explants were incubated with PGI2, PGH2 and PGE2 in the presence of theophylline (1mM) and the production of cyclic AMP was measured. PGE2 was found to be about 20 times more potent than PGI2 while PGH2 was slightly more effective than PGI2. The results suggest that PGI2 does not play a AMP was measured. PGE was found to be about 20 times more potent than physiological role in cyclic AMP mediated events in the rat anterior pituitary.
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism*; D006152:Cyclic GMP / Q000096:biosynthesis / Q000378:metabolism*; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology; D011463:Prostaglandins H / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D011453:Prostaglandins; D011458:Prostaglandins E; D011463:Prostaglandins H; D011464:Epoprostenol; D000242:Cyclic AMP; D006152:Cyclic GMP