title: Current concepts of the mechanism of acute inflammation in gouty arthritis.
abstract: The acute gouty attack develops after free crystalline monosodium urate crystals appear in the joint cavity (1). Recent developments in the investigation of urate crystal-induced inflammation have led to a better understanding of the pathogenesis of acute gouty arthritis. The purpose of this review is to summarize present concepts concerning the mechanism of the acute gouty attack.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001168:Arthritis / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D002633:Chemotaxis; D003165:Complement System Proteins; D003460:Crystallization; D005174:Factor XII / Q000378:metabolism; D006073:Gout / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D007962:Leukocytes / Q000276:immunology / Q000502:physiology; D010587:Phagocytosis; D013582:Synovial Fluid / Q000032:analysis; D014527:Uric Acid / Q000032:analysis / Q000378:metabolism
chemical_list: D007705:Kinins; D014527:Uric Acid; D005174:Factor XII; D003165:Complement System Proteins; D007610:Kallikreins