title: [Molecular mechanisms of hypothalamic hexapeptide regulation of the links in glycogen metabolism].
abstract: Alterations in content of glycogen as well as in activity of phosphorylase and phosphoprotein phosphatase were studied in various rat tissues after intravenous administration of a new hypothalamic hexapeptide Tyr-Gly-Leu-Pro-Gly-NH2. An increase in phosphoprotein phosphatase activity was observed in heart muscle, which correlated with transformation of phosphorylase A to the B form and with accumulation of glycogen. The opposite effect was found in liver tissue and sceletal muscle.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism*; D007031:Hypothalamus; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008967:Molecular Biology; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats
chemical_list: D008112:Liver Glycogen; D010455:Peptides; D006003:Glycogen; D006005:Phosphorylases; D010749:Phosphoprotein Phosphatases
vernacular_title: Molekuliarnye mekhanizmy reguliatsii gipotalamicheskim geksapeptidom nekotorykh zven'ev obmena glikogena.