title: Attempted immunologic reconstitution of patients with combined immune deficiency syndrome with bone marrow transplantation from histoincompatible donors.
abstract: The immunologic reconstitution from patients with combined immune deficiency syndrome was attempted with bone marrow transplantation from histoincompatible donors. None of the patients achieved long-term immunologic reconstitution. In all cases, the incompatible bone marrow was treated before transplantation. Physical separation of the stem and immunocompetent cells was attempted in 2 cases with the use of enhancing antibody in one of the attempts. The selective destruction of the immunocompetent bone marrow cells after specific stimulation was attempted in the last 2 cases.
mesh_terms: D000921:Antibody-Producing Cells; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D001973:Bromodeoxyuridine; D002469:Cell Separation; D005838:Genotype; D006087:Graft vs Host Reaction; D006412:Hematopoietic Stem Cells; D006648:Histocompatibility; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000628:therapy*; D010375:Pedigree; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous; D014316:Tritium
chemical_list: D014316:Tritium; D001973:Bromodeoxyuridine; D013936:Thymidine