title: Effect of ornithine alpha oxoglutarate on brain metabolism in patients with chronic liver disease.
abstract: Patients with chronic liver disease, yet without severe encephalopathy, were found to show evidence of increased brain utilization of glucose. The changes were abolished after an intravenous infusion of 15 g ornithine alpha oxoglutarate, given over a period of 15 minutes. The possible implications of these observations are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002540:Cerebral Cortex / Q000098:blood supply; D002908:Chronic Disease; D004569:Electroencephalography; D005260:Female; D005947:Glucose / Q000378:metabolism; D006501:Hepatic Encephalopathy / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009952:Ornithine / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D000600:Amino Acids, Dicarboxylic; D001786:Blood Glucose; D007656:Ketoglutaric Acids; D007773:Lactates; D002245:Carbon Dioxide; D009952:Ornithine; D005947:Glucose; D010100:Oxygen