title: Natural hypocholesterolemic agent: pectin plus ascorbic acid.
abstract: An addition of 5% citrus pectin and 0.5% ascorbic acid to high-fat diet of guinea pigs prevented total cholesterol accumulation in blood serum and the liver. Two groups of persons were given a preparation containing a daily dose of 15 g pectin and 450 mg ascorbic acid for 6 weeks. In 21 healthy persons with mild hypercholesterolemia total serum cholesterol dropped significantly by 24 mg/100 ml (8.6%), while the concentration of high density lipoprotein cholesterol remained unchanged. In 11 hyperlipemic outpatients (type IIa, IIb and IV) total serum cholesterol dropped by 68 mg/100 ml (18.7%). The changes in triglyceridemia proved inconsistent.
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents; D001205:Ascorbic Acid / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D005215:Fasting; D006168:Guinea Pigs; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D006949:Hyperlipidemias / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D010368:Pectins / Q000494:pharmacology*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008075:Lipoproteins, HDL; D014280:Triglycerides; D010368:Pectins; D002784:Cholesterol; D001205:Ascorbic Acid