Effects of [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3',5'-nucleotide formation and phosphodiesterase activity.
The orally-effective antiallergic compound [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) exhibited a potency equivalent to or 3 times less than theophylline in inhibiting guinea-pig lung and beef heart PDE, respectively, AY-25,674 did not affect the basal activity of guinea-pig lung adenyl cyclase. Although part of the antiallergic activity of AY-25,674 may be due to the ability to elevate cyclic AMP levels by PDE inhibition, other modes of action appear to be of greater relevance.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000085:Acetates / Q000494:pharmacology*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000625:Aminooxyacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D003508:Cycloheptanes / Q000494:pharmacology*; D006168:Guinea Pigs; D007166:Immunosuppressive Agents; D008168:Lung / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010726:Phosphodiesterase Inhibitors
D000085:Acetates; D003508:Cycloheptanes; D007166:Immunosuppressive Agents; D010726:Phosphodiesterase Inhibitors; D000625:Aminooxyacetic Acid; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases