title: Protein metabolism in uraemia.
abstract: Protein metabolism in uraemia is reviewed. Very few, if any, disorders of amino acid metabolism can at present confidently be attributed to uraemia per se rather than to protein/energy deprivation. Retained urea nitrogen is recycled to the liver as ammonia; a proportion is reutilized for synthesis of non-essential amino acids and, if their carbon skeletons are supplied, for synthesis of essential amino acids. Practical applications of the reutilization of non-amino nitrogen in advanced chronic renal failure are being explored. Nevertheless, uraemic individuals readily become undernourished, and they should receive as much protein as their symptoms will permit.
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000096:biosynthesis; D000601:Amino Acids, Essential / Q000096:biosynthesis; D000641:Ammonia / Q000378:metabolism; D001806:Blood Urea Nitrogen; D004044:Dietary Proteins; D005243:Feces / Q000201:enzymology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000032:analysis / Q000378:metabolism; D009748:Nutrition Disorders / Q000209:etiology; D009751:Nutritional Requirements; D011506:Proteins / Q000378:metabolism*; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014510:Urease / Q000032:analysis; D014511:Uremia / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D014633:Valine / Q000032:analysis
chemical_list: D000596:Amino Acids; D000601:Amino Acids, Essential; D004044:Dietary Proteins; D011506:Proteins; D012709:Serum Albumin; D000641:Ammonia; D014508:Urea; D014510:Urease; D014633:Valine; D009584:Nitrogen