Inhibition of striatal dopamine synthesis in rats injected chronically with neuroleptics in their early life.
3H-dopamine synthesis from L-3,5-3H-tyrosine was reduced in striatal slices of 40 days old rats treated during their early life with neuroleptics. Animals were first injected intra-utero with thioproperazine (5 mg/kg) or with the palmitic ester of pipotiazine (32 mg/kg); the thioproperazine-treated rats were then injected every day from day 1 to day 37; the animals injected with the long acting neuroleptic were injected once more with the drug on day 15 after birth.
D000818:Animals; D000831:Animals, Newborn; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D004298:Dopamine / Q000096:biosynthesis*; D005260:Female; D009638:Norepinephrine / Q000378:metabolism; D010640:Phenothiazines / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013843:Thiazines / Q000494:pharmacology*; D014443:Tyrosine / Q000378:metabolism
D014150:Antipsychotic Agents; D010640:Phenothiazines; D013843:Thiazines; D014443:Tyrosine; D004298:Dopamine; D009638:Norepinephrine