Why cell biologists should be aware of genetically transmitted viruses.
Retrovirus genomes exist as endogenous genetic elements in the cells of many species used in biomedical research. Many cell lines spontaneously release virus, and other cells are induced to do so by procedures commonly used in research laboratories. The expression of endogenous retroviruses can affect the results of seemingly unrelated experiments. Some retroviruses endogenous to animals grow avidly in human cells. They are not known to be hazardous to man, but further studies are necessary.
D000818:Animals; D002478:Cells, Cultured / Q000382:microbiology*; D005814:Genes, Viral; D006801:Humans; D012107:Research Design; D012190:Retroviridae / Q000235:genetics* / Q000472:pathogenicity; D012449:Safety; D013045:Species Specificity; D014779:Virus Replication