Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration.
Dopamine increases adenosine 3',5'-monophosphate (cyclic AMP) but not guanosine 3',5'-monophosphate (cyclic GMP) in slices of bovine sympathetic ganglion; this increase is localized to the postganglionic neurons. Conversely, acetylcholine increases cyclic GMP but not cycle AMP in the ganglion; this increase also occurs within postganglionic neurons. Thus, different neurotransmitters can selectively alter cyclic nucleotide levels within the same neuronal population.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology; D005725:Ganglia, Autonomic / Q000187:drug effects; D066298:In Vitro Techniques; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D013268:Stimulation, Chemical
D018377:Neurotransmitter Agents; D000242:Cyclic AMP; D006152:Cyclic GMP; D000109:Acetylcholine; D004298:Dopamine