title: Infectious mononucleosis and agranulocytosis.
abstract: Infectious mononucleosis is often complicated by haematological abnormalities but agranulocytosis is so rare that a causal relationship has been questioned. We here describe 2 sisters, 3 and 5 years old, who both developed agranulocytosis or profound granulocytopenia 4-5 weeks after the acute onset of mononucleosis. No contributory cause could be found and we conclude that a constitutional disposition may be responsible for this complication.
mesh_terms: D000380:Agranulocytosis / Q000209:etiology* / Q000235:genetics; D001854:Bone Marrow Cells; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000235:genetics