Local graft-versus-host-reaction in mice specifically inhibited by anti-receptor antibodies.
The local graft-versus-host (GVH) reaction provoked by parental spleen cells in F1 mice was shown to be T-cell-dependent. GVH reactions were suppressed in F1 hybrid mice immunized with parental T lymphocytes of the same genotype, but not in F1 mice immunized with parental B cells. In some cases this immunity could be passively transferred by serum into normal F1 mice. The specific activity of such sera could be removed by absorption with either parental T or B cells. Some of the F1 antisera were specificlly cytotoxic for parental GVH-reactive lymphocytes.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006087:Graft vs Host Reaction; D007106:Immune Sera; D007114:Immunization; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000033:anatomy & histology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D007106:Immune Sera; D003165:Complement System Proteins