Fluoride inhibition of polymorphonuclear leukocytes.
Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5 and 0.0 mM F- for O2- generation, 1-C14 CO2 release labeled glucose and NBT-reduction respectively. This inhibition resulted primarily from F- suppression of nonoxidative glucose metabolism. As the concentration of F- in the O2- generating system increased beyond 10 mM, a rise in production of O2- anion occurred, peaking at 20 mM F-, followed by a rapid decline.
D002245:Carbon Dioxide / Q000378:metabolism; D005459:Fluorides / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010084:Oxidation-Reduction; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D002245:Carbon Dioxide; D009580:Nitroblue Tetrazolium; D005947:Glucose; D005459:Fluorides