Inhibition and enhancement of avian adenovirus plaque production by heavy and light avian adenovirus-associated viral particles.
The effect of heavy and light avian adenovirus-associated viral (A-AV) particles on the replication of several adenovirus serotypes was studied in chicken embryo kidney cells. There was a significant decrease (P less than 0.05) in the number and size of adenovirus-induced plaques at A-AV multiplicities of infection greater than 40. Enhancement of plaque production was observed when A-AV multiplicities of infection were 1 to 40. There was a significant increase in the number and size of infective centers. Analysis of cellular yields indicated an increase in the number of adenoviruses produced per cell. Heavy A-AV particles of buoyant density 1.42 g/cm3 in CsCl were found to enhance plaque production more than light particles (1.38 g/cm3). Conversely, light particles showed greater inhibition of plaque production. Adenovirus serotypes varied in their response to enhancement or inhibition by A-AV particles of different density.
D000256:Adenoviridae / Q000254:growth & development*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D000259:Aviadenovirus / Q000254:growth & development*; D002642:Chick Embryo; D000229:Dependovirus / Q000502:physiology*; D014779:Virus Replication
D000998:Antiviral Agents