Effect of nicomol on HDL cholesterol level.
In cardiovascular diseases with potential atherosclerosis, the serum concentration of HDL cholesterol as determined by a precipitation method with dextran sulfate and Mg++ was lower while that of total cholesterol was normal or elevated. Treatment with a daily dose of 1,200 mg of Nicomol, a derivative of nicotinic acid, for 1 to 3 months increased the mean HDL cholesterol level by 3 to 5 mg/dl and reduced the total cholesterol level by 14 to 15 mg/dl and total/HDL cholesterol ratio by 0.8 (3 months) to 0.9 (1 month, p less than 0.05). Similar decreases in HDL cholesterol concentration were also found in parenchymal and obstructive liver diseases with normal total cholesterol values except in fulminant hepatitis and intrahepatic cholestasis.
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood* / Q000188:drug therapy; D002784:Cholesterol / Q000097:blood*; D003511:Cyclohexanols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008107:Liver Diseases / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000627:therapeutic use*
D003511:Cyclohexanols; D008075:Lipoproteins, HDL; D009539:Nicotinic Acids; C008612:nicomol; D002784:Cholesterol