[Diagnosis methods in Sjögren's syndrome (author's transl)].
The diagnosis value of various methods used to detect or confirm a Sjögren's syndrome are discussed. The Schirmer's test, generally abnormal, is a good test for detection, although not specific. A subnormal concentration of tears lysozyme is seen in about half of the patients, as so as the presence of anti-salivary ducts antibodies, or significant aspects in lip biopsy. The tests that are most frequently disturbed are the salivary immunoglobulin assay and the fonctionnal study of salivary glands with 99m technetium tracer but they are not specific. These abnormalities are neither constant, not specific: for this reason, there are frequently some problems in the diagnosis or the nosologic definition of Sjögren's syndrome. The occurrence in the same subject of many of these abnormalities makes however this diagnosis highly probable even in patients without functionnal troubles.
D001323:Autoantibodies / Q000032:analysis; D001706:Biopsy; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008046:Lip / Q000473:pathology; D009113:Muramidase / Q000032:analysis; D012463:Saliva / Q000032:analysis / Q000276:immunology; D012470:Salivary Glands, Minor / Q000276:immunology; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000473:pathology; D013666:Tears / Q000032:analysis / Q000201:enzymology
D001323:Autoantibodies; D007136:Immunoglobulins; D009113:Muramidase
Méthodes de diagnostic du syndrome de Sjögren.