title: [Effect and tolerance of Phanurane in the treatment of essential hypertension. (Double blind study) (author's transl)].
abstract: A double-blind study of Phanurane and placebo was conducted on 61 patients with mild essential hypertension. Each patient received 2 gelules daily (2 X 50 mg of canrenone) during a 2 month period. Statistical analysis has shown that patients on Phanurane experienced a significant decrease in systolic and diastolic blood pressure compared with patients on placebo. Clinical tolerance of canrenone was excellent. Uric acid and triglyceride levels remained normal.
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002192:Canrenone / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011245:Pregnadienes / Q000627:therapeutic use*
chemical_list: D011245:Pregnadienes; D002192:Canrenone
vernacular_title: Etude randomisée en double aveugle de l'efficacité du Phanurane et de sa tolérance clinique et biologique chez l'hypertendu.