title: [Tercuronium, a new nondepolarizing myorelaxant with high activity and selective action].
abstract: Tercuronium is p',p"-bis-triethylammonium-p-terphenyl dibenzosulfonate. As a curarelike agent tercuronium is 4--8 times as potent as (+)-tubocurarine. The time of the development and lasting of the blocking effect of tercuronium is approximately the same as that of (+)-tubocurarine. In a blocking dose tercuronium does not exert any effect either on the vegetative ganglia or arterial blood pressure. Partial blocking of the transmission through the vegetative ganglia as well as an insignificant and short-term drop of arterial blood pressure are recorded after intravenous injection of 10 myoparalytic doses of tercuronium. The antagonism of neostigmine against tercuronium was more pronounced than against (+)-tubocurarine, pancuronium and gallamine.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central; D009469:Neuromuscular Junction / Q000502:physiology; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects; D013730:Terphenyl Compounds / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
chemical_list: D009125:Muscle Relaxants, Central; D013730:Terphenyl Compounds
vernacular_title: Terkuronii--novyĭ nedepoliarizuiushchiĭ miorelaksant s vysokoĭ aktivnost'iu i izbiratel'nost'iu deĭstviia.