Activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase in human cerebrospinal fluid.
Activity of the myelin marker enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) was assayed in cerebrospinal fluid samples obtained from patients with multiple sclerosis (MS) and other neurological diseases. The enzyme activity was found to be elevated in acute cases of MS and reduced during remission. It was present in other demyelinating diseases, and no activity was detected in normal CSF. CNP may be released into CSF from any insult to myelin. The level of activity appears to reflect demyelination and the rate of breakdown of the myelin sheath.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000134:cerebrospinal fluid*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid* / Q000201:enzymology; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009712:Nucleotides, Cyclic / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000134:cerebrospinal fluid*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism
D009712:Nucleotides, Cyclic; D010744:Phosphoric Monoester Hydrolases; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases