Gastric carcinoma in dogs produced by the combined use of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and gastrin--with special reference to development of scirrhous carcinoma.
Eight beagle dogs of four-month-old received both oral administration of N-Ethyl-N'-Nitro-N-Nitrosoguanidine (ENNG) and subcutaneous injection of gastrin, and one of them was found to have an annularly infiltrating advanced carcinoma with marked fibrous thickening of the antral wall resulting in stenosis of the antrum (carcinoma scirrhosum) which resembled "Linitis plastica" (Borrmann's type IV carcinoma) in human stomach.
D002293:Adenocarcinoma, Scirrhous / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens; D004285:Dogs; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000008:administration & dosage / Q000633:toxicity*; D008769:Methylnitronitrosoguanidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D005755:Gastrins; D008769:Methylnitronitrosoguanidine; C013525:ENNG