Modulation of T cells and macrophages by cholera toxin treatment in vivo and in vitro.
Cholera Toxin influences the antibody response to SRBC. Enhanced responses occur in vivo and in vitro when CT is added together with antigen. However, CT depresses antibody formation when given in vivo before antigen but enhances in vitro responses under the same conditions. Modulation of antibody formation appeared due to effects of T lymphocytes as well as macrophages. Co-cultivation of immunologically impaired spleen cells from CT pretreated animals with macrophage-rich peritoneal cells or educated T cells increased the antibody response.
D000818:Animals; D000917:Antibody Formation; D001202:Ascitic Fluid / Q000166:cytology; D002772:Cholera Toxin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000096:biosynthesis; D004912:Erythrocytes / Q000276:immunology; D007156:Immunologic Memory; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012756:Sheep; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D002772:Cholera Toxin; D000242:Cyclic AMP