Metabolism of phenothiazines: identification of N-oxygenated products by gas chromatography and mass spectrometry.
The solid inlet mass spectra of the N-oxide and N-oxide sulphoxide metabolites of promazine, chlorpromazine and methotrimeprazine have been determined at different temperatures and compared with the mass spectra of the main thermolytic product of the N-oxides and N-oxide sulphoxides obtained during combined gas chromatography-mass spectrometry. Diagnostic ions were produced by direct insertion of the compounds at ambient temperature into the mass spectrometer. These ions distinguish the N-oxides of arylalkyl tertiary amines from the N-oxygenated derivatives of primary and secondary arylalkylamines.
D002746:Chlorpromazine / Q000032:analysis; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003497:Cyclic N-Oxides / Q000032:analysis; D003499:Cyclic S-Oxides / Q000032:analysis; D013058:Mass Spectrometry; D008728:Methotrimeprazine / Q000032:analysis; D010640:Phenothiazines / Q000032:analysis*; D011395:Promazine / Q000032:analysis
D003497:Cyclic N-Oxides; D003499:Cyclic S-Oxides; D010640:Phenothiazines; D008728:Methotrimeprazine; D011395:Promazine; D002746:Chlorpromazine