[Fibre interaction with red blood cells or alveolar macrophages "in vitro" (author's transl)].
Haemolytic activities and effects on alveolar macrophages (AM) of various fibres were studied. UICC asbestos fibres and attapulgites either untreated or acid-leached were used. Amphiboles and commercial attapulgites were both cytotoxic on AM, but attapulgites and chrysotile were only haemolytic. Chrysotile fibres induced a release of B galactosidase; when acid treated these fibres were cytotoxic and less haemolytic. Acid treated amphiboles were more haemolytic than untreated.
D001194:Asbestos / Q000633:toxicity*; D017636:Asbestos, Amphibole; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects*; D008274:Magnesium / Q000633:toxicity*; D017616:Magnesium Compounds; D011650:Pulmonary Alveoli / Q000187:drug effects*; D012825:Silicon / Q000633:toxicity*; D017655:Silicon Compounds; D012822:Silicon Dioxide / Q000633:toxicity*; D001616:beta-Galactosidase / Q000097:blood
D017636:Asbestos, Amphibole; D017616:Magnesium Compounds; D017655:Silicon Compounds; D001194:Asbestos; D012822:Silicon Dioxide; D001616:beta-Galactosidase; D008274:Magnesium; C026325:attapulgite; D012825:Silicon
Interaction des fibres avec les globules rouges et les macrophages alvéolaires in vitro.