Cyproheptadine treatment of Nelson's syndrome: restoration of plasma ACTH circadian periodicity and reversal of response to TRF.
Administration of cyproheptadine for four months to a patient with Nelson's Syndrome was associated with evidence of skin lightening, decreased plasma ACTH concentrations, return of a normal circadian periodicity of plasma ACTH concentrations, and lack of responsiveness of plasma ACTH concentrations to TRF administration, in contrast to the response seen in the untreated state.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002940:Circadian Rhythm; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009347:Nelson Syndrome / Q000188:drug therapy*; D010911:Pituitary Neoplasms / Q000188:drug therapy*; D013973:Thyrotropin-Releasing Hormone
D003533:Cyproheptadine; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone