Adenosine triphosphatase activity in few tissues of a fresh water teleost, Channa gachua following in vivo exposure to endosulfan.
Fresh water teleost fish, Channa gachua, were chronically exposed to various sublethal concentrations of endosulfan (0.00534, 0.00355, 0.00213 and 0.00174 mg/1) at 25 +/- 4 degrees C for 30 and 60 days respectively. The study shows enzyme inhibitions, greatest in oligomycin-insensitive Mg2+ ATPase in brain, gill and liver tissues, with pronounced effects at highest endosulfan concentration for 60 days exposure. However, in kidney the highest inhibition was of oligomycin-sensitive (mitochondrial) Mg2+ ATPase. The study indicates that endosulfan interferes with energy metabolism in vivo. The marked sensitivity of mitochondrial Mg2+ ATPase to endosulfan is suggestive of the potential for endosulfan to interfere markedly with various energy requiring processes in the fish body.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D004726:Endosulfan / Q000494:pharmacology*; D005399:Fishes / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D009840:Oligomycins / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D009840:Oligomycins; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D004726:Endosulfan