Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica.
Long-term habituation training in Aplysia californica produces a profound depression in the efficacy of synaptic transmission between mechanoreceptor neurons and gill motor neurons. This depression persists for more than 3 weeks. Thus a critical synaptic site for plasticity underlying long-term habituation is the same as that for short-term habituation. For this simple form of learning, short- and long-term memory share a common locus and aspects of a common mechanism: synaptic depression.
D000818:Animals; D001048:Aplysia; D005880:Gills / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D012023:Reflex, Monosynaptic; D012153:Retention, Psychology / Q000502:physiology; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission; D013997:Time Factors