Hyperuricemic nephropathy: pathologic features and factors influencing urate deposition.
The three general types of renal pathology associated with hyperuricemia are reviewed. Factors influencing urate solubility are discussed, as well as the effect of uricosuric drugs on renal urate handling, with particular emphasis upon their efficacy in competing with urate for protein binding sites. In addition, a new experimental model of hyperuricemic nephropathy is described which could yield valuable data concerning the complex relationships between hyperuricemia, urate deposition and renal function.
D058186:Acute Kidney Injury / Q000209:etiology; D000818:Animals; D001665:Binding Sites; D003460:Crystallization; D004195:Disease Models, Animal; D004232:Diuretics / Q000494:pharmacology; D006073:Gout / Q000097:blood / Q000150:complications*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000209:etiology; D007674:Kidney Diseases / Q000150:complications*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D012995:Solubility; D014527:Uric Acid / Q000097:blood*
D004232:Diuretics; D014527:Uric Acid; D012965:Sodium Chloride