Inhibition of the multiplication of herpes simplex virus by aliphatic nitrosamines.
Non-toxic doses of dimethylnitrosamine and diethylnitrosamine inhibit the multiplication of herpes simplex virus type 1 and type 2 in HEp-2, Wi-38 and primary HEK cells. These results are somewhat unexpected, since both HEp-2 and Wi-38 cells lack detectable microsomal enzyme activity. The possible significance of the preliminary results is discussed.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001711:Biotransformation; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D006801:Humans; D008861:Microsomes / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D018139:Simplexvirus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D009602:Nitrosamines; D004052:Diethylnitrosamine; D001189:Aryl Hydrocarbon Hydroxylases; D004128:Dimethylnitrosamine