Effect of flavoring oils on preservative concentrations in oral liquid dosage forms.
The partitioning of methyl-, ethyl-, propyl-, and butylparabens into flavoring oils from aqueous systems was studied. The partitioning is dependent on the concentration of the flavoring oil, the pH of the aqueous medium, and the nature and concentration of additives to the aqueous medium.
D002021:Buffers; D055598:Chemical Phenomena; D002621:Chemistry; D005421:Flavoring Agents; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D009821:Oils; D010226:Parabens; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D012965:Sodium Chloride; D012995:Solubility; D013329:Structure-Activity Relationship; D013395:Sucrose
D002021:Buffers; D005421:Flavoring Agents; D009821:Oils; D010226:Parabens; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D012965:Sodium Chloride; D013395:Sucrose