New side effect of the hypoxic cell sensitizer, misonidazole.
As part of a phase II study with the hypoxic cell radiosensitizer, misonidazole, we have encountered two cases of dermatitis. When all drugs were withdrawn and the patients were challenged with a small single dose of misonidazole, identical adverse reactions reappeared demonstrating a drug-related skin hypersensitivity.
D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D008297:Male; D008920:Misonidazole / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D009593:Nitroimidazoles / Q000009:adverse effects*
D009593:Nitroimidazoles; D008920:Misonidazole