title: Reactions of pyrzdoxal 5'-phosphate, 6-aminocaproic acid, cysteine, and penicilamine. Models for reactions of Schiff base linkages in pyridoxal 5'-phosphate-requiring enymes.
abstract: Schiff base formation, transaldimination, and reaction with aminothiols are important reactions which occur on the surface of pyridoxal-P-requiring enzymes. As a first step in assessing the role of the protein in these reactions, models for these reactions were studied in the absence of enzyme at 25 degrees, gamma/2 0.28. The reaction of 6-aminocaproic acid with pyridoxal-P to form the Schiff base N6-(P-pyridoxylidene)-aminocaproic acid was studied as a model for formation of Schiff base on the holoenzyme...
mesh_terms: D000614:Aminocaproates / Q000378:metabolism*; D000693:Anaerobiosis; D003545:Cysteine / Q000378:metabolism*; D004228:Dithionitrobenzoic Acid; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010396:Penicillamine / Q000378:metabolism*; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D012545:Schiff Bases; D013844:Thiazoles / Q000378:metabolism
chemical_list: D000614:Aminocaproates; D012545:Schiff Bases; D013844:Thiazoles; D011732:Pyridoxal Phosphate; D004228:Dithionitrobenzoic Acid; D010396:Penicillamine; D003545:Cysteine