[Development of a cellular immune response in a highly cancer-susceptible C3H/He strain of mice and its nonfactor substrain C3H/f after the transplantation of a syngeneic mammary gland tumor].
Syngeneic mammary gland tumor (MMT-1) grew slower in non-factor C3H/f (MTV-L) mice than in wirus-positive C3H/He (MTV-S) mice. The immunization of mice with tumor (MMT-1), inoculated and later excised, revealed a higher immune reactivity in the mice of the non-factor substrain. In studying the dynamics of the cytotoxic activity of lymphocytes in regional lymph nodes cytotoxically active lymphocytes were found to appear in C3H/f mice on day 6 after the inoculation of tumor (MMT-1), while the areactive state of lymphocytes was observed in C3H/He mice on days 3 and 24 and in C3H/f mice on day 24 after the inoculation of tumor (MMT-1). Spleen lymphocytes in C3H/f mice had no cytotoxic effect on tumor cells.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D007114:Immunization; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology*; D009368:Neoplasm Transplantation; D013997:Time Factors; D014181:Transplantation Immunology; D014185:Transplantation, Isogeneic
Razvitie kletochnogo immunogo otveta u mysheĭ vysokorakovoĭ linii C3H/He i ee besfaktornoĭ sublinii C3H/f posle transplantatsii im singennoĭ opukholi molochnoĭ zhelezy.