[Value of the timolol-hydrochlorothiazide-amiloride hydrochloride combination in the mass treatment of arterial hypertension. Results of a multinational study].
In a 10-week double-blind study, 283 hypertensive patients were treated with a beta-blocker (timolol) alone, a combination of two diuretics (hydrochlorothiazide + amiloride) or a combination of both types of treatment. The results on blood pressure figures were very much in favor of the combination therapy as compared to monotherapy. In a second step, the trial was unblinded and all patients continued with the beta-blocker/diuretic combination for a total of 24 weeks. The medium-term results confirmed those obtained during the double-blind study with regard to the effectiveness and good tolerance of the combination treatment.
D000584:Amiloride / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D011412:Propanolamines / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*
D011412:Propanolamines; D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride; D013999:Timolol
Intérét de l'association timolol/hydrochlorothiazide/chlorhydrate d'amiloride dans le traitement de masse de l'hypertension artérielle. Résultats d'une étude multinationale.