Hybrid resistance to BALB/c plasmacytomas. II. Radiation sensitivity and silica insensitivity of resistance to MPC-11.
Resistance to the BALB/c plasmacytoma MPC-11 by F1 hybrids between BALB/c and four C57BL/10 congenic resistant strains was abrogated or reduced by 450 rads total body irradiation but was unaffected by intravenous injection of 3 to 4 mg of silica. The results are consistent with the idea that hybrid resistance to MPC-11 depends on an active immune response and is different from Hh-1 controlled hybrid resistance.
D000818:Animals; D005260:Female; D006824:Hybridization, Genetic; D007113:Immunity, Innate / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010954:Plasmacytoma / Q000401:mortality / Q000517:prevention & control*; D011828:Radiation Chimera; D012822:Silicon Dioxide / Q000494:pharmacology*; D013997:Time Factors
D012822:Silicon Dioxide