The offspring of schizophrenics. Fetal and neonatal deaths.
This is the first report in a projected series on neurological development among the offspring of schizophernics. An increased incidence of fetal and neonatal deaths is noted among offspring of schizophrenics when compared to a closely matched control group, using data collected prospectively. In many cases, no apparent reason for death was determined; in some cases, major neurological malformations were found. It is necessary to consider three possible explantions for these findings--genotype of the child, adverse intrauterine environment, and medication toxicity.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000401:mortality; D000022:Abortion, Spontaneous / Q000453:epidemiology; D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001714:Bipolar Disorder / Q000175:diagnosis; D002490:Central Nervous System / Q000002:abnormalities; D002908:Chronic Disease; D005260:Female; D005313:Fetal Death / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D010640:Phenothiazines; D011247:Pregnancy; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012737:Sex Factors; D012923:Social Class
D014150:Antipsychotic Agents; D010640:Phenothiazines