title: Effect of prostaglandins on the increased corticosterone output induced by caffeine in the rat.
abstract: The effect of prostaglandins on the increase of corticosterone output induced by caffeine was investigated in rats. PGE2 and some synthetic prostaglandins (11-deoxy-derivatives), which stimulate steroid output in vitro, enhanced the effect of caffeine. Pretreatment with indomethacin inhibited the effect of caffeine.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D003345:Corticosterone / Q000096:biosynthesis* / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats
chemical_list: D011459:Prostaglandins E, Synthetic; D002110:Caffeine; D000242:Cyclic AMP; D003345:Corticosterone; D007213:Indomethacin