[Characteristics of the effect of estradiol on prolactin secretion by adenohyophyseal cells from intact and ovariectomized rats in primary monolayer cultures].
Estradiol directly stimulated the secretion of prolactin by the adenohypophyseal cells of intact rats in a monolayer culture. Complex interactions between estradiol and some other regulators of the hypophyseal lactotropic function were revealed. It was established that changes in prolactin synthesis and secretion in ovariectomized rats persisted for 3--4 days of adenohypophyseal cell cultivation in vitro.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002369:Castration; D002478:Cells, Cultured; D004298:Dopamine / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D010053:Ovary / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D003994:Bucladesine; D011388:Prolactin; D004298:Dopamine
Osobennosti vliianiia éstradiola na sekretsiiu prolaktina kletkami adenogipofiza intaktnykh i ovariéktomirovannykh krys v pervichnykh monosloĭnkh kul'turakh.