Risk of radiation-related subsequent malignant tumors in survivors of Ewing's sarcoma.
Twenty-four long-term survivors of Ewing's sarcoma were identified as being at risk for a second primary tumor. Among this group of patients followed from 3 to 22 years, 4 new bone tumors were observed, whereas 1.2 x 10(-3) were expected. All new tumors arose in heavily irradiated areas. The risk associated with radiation after 3 years was 7.2 cases/million person-years per rad. The cumulative cancer risk over 10 years for irradiated patients was 35% (SE, 15.1%). Intensive chemotherapy (cyclophosphamide and vincristine administered in five or more courses) seemed to exert an enhancing effect, increasing the rate of development of new tumors.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001859:Bone Neoplasms / Q000209:etiology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D012516:Osteosarcoma / Q000209:etiology; D011879:Radiotherapy Dosage; D012306:Risk; D012512:Sarcoma, Ewing / Q000628:therapy*; D012878:Skin Neoplasms / Q000209:etiology; D013997:Time Factors
D000970:Antineoplastic Agents