[Dependence of [14C] nicotinate and [35S] lipoate transport to erythrocytes on their Mg2+, Na+, K+-ATPase activity].
Nicotinic acid added to the incubation medium stimulates ATPase activity in erythrocytes and their membranes. Simultaneously the ouabain-sensitive ATPase activity is activated. The mentioned effect is not observed when lipoic acid is added to the medium. Accumulation of [14C]nicotinate and [35S]lipoate in biostructures occurs more intensely under conditions optimal for the Mg2+, Na+, K+-ATPase activity. In experiments with "traces" of erythrocytes it is shown that the gradient of Na+ and K+ favours to the transport of [35S] lipoate.
D000818:Animals; D001693:Biological Transport, Active; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D009539:Nicotinic Acids / Q000097:blood* / Q000494:pharmacology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*; D008063:Thioctic Acid / Q000097:blood* / Q000494:pharmacology
D009539:Nicotinic Acids; D008063:Thioctic Acid; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium
Zavisimost' trancporta [14C] nikotinata i [35S] lipoata v eritrotsity ot ikh Mg2+, Na+, K+-ATP-aznoĭ aktivnosti.