Effect of low-dose-rate irradiation on the division potential of cells in vitro. V. Human skin fibroblasts from donors with a high risk of cancer.
Skin fibroblasts from normal donors, donors with ataxia-telangiectasia or Fanconi's anemia, and from 1 cancer patient were treated with repeated gamma-radiation at about 16 rads per hour. The remaining division potential of all fibroblasts, except for the Fanconi's anemia cells, was reduced to different extents by radiation. The growth potential of Fanconi's anemia cells was increased in all the irradiated cultures. The increase was 54% in the group that survived the longest. These results were identical to those obtained with fibroblasts from certain species that have a high probability of transformation.
D001260:Ataxia Telangiectasia / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002455:Cell Division / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000473:pathology; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000473:pathology; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology*; D011829:Radiation Dosage; D012867:Skin / Q000166:cytology / Q000528:radiation effects