The mode of action alginic acid compound in the reduction of gastroesophageal reflux.
This study was designed to evaluate quantitatively the mode of action of alginic acid compound (AAC) in the treatment of patients with symptomatic gastroesophageal reflux. Gastroesophageal scintigraphy using an orall administered Tc-99m sulfur colloid solution was used to demonstrate that AAC decreased significantly the gastroesophageal reflux index from (9.9 +/- 1.3) % to (6.5 +/- 0.8) % (p less than 0.05). No alteration of lower esophageal sphincter pressure was observed. After ACC was suitably labeled with Sr-87m, a dual-nuclide scintigraphic technique was used to show that most (greater than 75%) of the AAC was located in the upper half of the stomach in both normal subjects and patients with gastroesophageal reflux. In those subjects in whom reflux did occur after treatment with AAC, the Sr-87m-AAC refluxed into the esophagus preferentially compared with the liquid containing Tc-99m sulfur colloid. These findings suggest that AAC dimishes gastroesophageal reflux by means of its foaming, floating, and viscous properties.
D000328:Adult; D000464:Alginates / Q000494:pharmacology* / Q000627:therapeutic use; D000536:Aluminum Hydroxide / Q000494:pharmacology* / Q000627:therapeutic use; D000863:Antacids / Q000494:pharmacology* / Q000627:therapeutic use; D001639:Bicarbonates / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D004943:Esophagogastric Junction / Q000000981:diagnostic imaging / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D011312:Pressure; D011877:Radionuclide Imaging; D012824:Silicic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D012822:Silicon Dioxide / Q000494:pharmacology*; D017693:Sodium Bicarbonate; D014783:Viscosity
D000464:Alginates; D000863:Antacids; D001639:Bicarbonates; D004338:Drug Combinations; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate