title: Modification of immune response in nude mice infected with mouse hepatitis virus.
abstract: In nude mice experimentally infected with mouse hepatitis virus (MHV), the numbers of early and later plaque forming cells (PFC) to sheep red blood cells (SRBC) generated in the spleen were 7 to 20 times and 2 to 163 times, respectively, greater than those in non-infected nude mice, when SRBC were given at day 0 to day 21 postinfection. Splenic theta-positive lymphocytes in infected nude mice were shown to increase only at day 10 or more postinfection. PFC response to bacterial lipopolysaccharide, a T cell-independent antigen, was not modified in MHV-infected nude mice.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008819:Mice, Nude; D006517:Murine hepatitis virus / Q000276:immunology*; D013154:Spleen / Q000276:immunology
chemical_list: D008070:Lipopolysaccharides