Interferon production by mammalian cells grown in a serum-free medium.
Interferon, produced by rabbit heart cells grown in a serum-free medium, failed to protect rabbit heart serum-free cells, but protected rabbit heart serum-containing-medium cells against vaccinia and vesicular stomatitis virus. Interferon produced in serum-free cells had a greater species specificity than that produced in serum-containing media. The difference in activity was shown to be due to lack of adsorption by serum-free-medium cells.
D000818:Animals; D001769:Blood; D002460:Cell Line; D003470:Culture Media; D006321:Heart; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology; D011817:Rabbits; D013045:Species Specificity; D014616:Vaccinia virus / Q000254:growth & development; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects
D003470:Culture Media; D007372:Interferons