[Cardiotropic effects of luliberin. Interaction with rat heart sarcolemmal membrane].
Studies of the effects of luliberin (luteinizing hormone-releasing hormone) on cardiac cells showed that the hormone is specifically bound by the sarcolemmal membrane. The activity of the membrane enzyme -- reception of luliberin involves two types of binding sites with high (K' = 10(7) M-1) and low (K'' = 10(5) M-1) affinities for the hormone, respectively. The hormone has no effect on the activities of adenylate cyclase and phosphodiesterase.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000378:metabolism; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D012508:Sarcolemma / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D011956:Receptors, Cell Surface; D007987:Gonadotropin-Releasing Hormone; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase
Kardiotorpnoe deĭstvie liuliberina. Vzaimodeĭstvie s sarkolemmal'noĭ membranoĭ serdtsa krys.