Multihormonal pituitary adenomas.
66 pituitary tumors detected at autopsy were investigated for the presence of corticotropin, beta-lipotrophin, growth hormone, prolactin, thyrotropin and gonadotropins by immunocytochemistry. 56 tumors contained hormone-producing cells; 45 were found to contain 2 or more hormones. This finding confirms and extends previous morphologic and clinical observations. The majority of pituitary tumors are mixed and they probably arise from impaired regulation at the hypothalamic and/or pituitary level.
D000172:Acromegaly / Q000150:complications; D000236:Adenoma / Q000032:analysis* / Q000150:complications; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000368:Aged; D003480:Cushing Syndrome / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D013006:Growth Hormone / Q000032:analysis; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000032:analysis* / Q000150:complications; D011388:Prolactin / Q000032:analysis; D013967:Thyroiditis, Autoimmune / Q000150:complications; D013972:Thyrotropin / Q000032:analysis; D008083:beta-Lipotropin / Q000032:analysis
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D008083:beta-Lipotropin