title: Pathology of the placenta and newborn pups with suspected intrauterine infection of canine herpesvirus.
abstract: Pathologic and virologic investigations were done on the fetal placenta and on pup runts which were obtained from a bitch with a medical history of canine herpesvirus (CHV) infection. Macroscopically, the placenta was poorly developed. Small grayish white foci were observed in the placental labyrinth. Characteristic lesions of CHV infection were not prominent in the pups examined. Microscopically, however, focal degenerative and necrotizing lesions were observed in the placental labyrinth. Rarely, eosinophilic or basophilic intranuclear inclusion bodies were in the trophoblastic cells in the necrotizing lesions. In the adrenal gland of one stillborn pup, focal necrosis and hemorrhages could be seen; these irregularities were essentially the same as those seen in the newborn pups with CHV infection. Focal interstitial pneumonia was also observed in some of the pups. The CHV organism was isolated from the kidney of one pup that survived for 22 days.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004283:Dog Diseases / Q000473:pathology* / Q000635:transmission; D004285:Dogs; D005260:Female; D005315:Fetal Diseases / Q000662:veterinary*; D006564:Herpesviridae / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000473:pathology / Q000635:transmission / Q000662:veterinary*; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy