The presence of herpes simplex virus DNA in hamster embryo cells transformed by a temperature sensitive mutant, TS-4.
Hamster embryo cells transformed with a temperature sensitive mutant of HSV-2, ts-4T, were examined for the presence of viral genomes. DNA-DNA reassociation kinetics showed that only a small portion (11 +/- 4%) of HSV-2 was present in the transformed cells.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D006224:Cricetinae; D004279:DNA, Viral / Q000032:analysis*; D005814:Genes, Viral; D009154:Mutation; D009695:Nucleic Acid Renaturation; D018139:Simplexvirus / Q000235:genetics* / Q000502:physiology; D013696:Temperature
D004279:DNA, Viral