Studies on a strain of Fusarium solani (Mart.) Sacc. Isolated from a case of mycotic keratitis.
A strain of Fusarium solani (Mart.) Sacc. (IMI-216517), isolated from a patient of mycotic keratitis, produced experimental keratomycosis in albino rabbit cornea and survived in internal tissues of albino mice for varying periods. Alantolactone, isolated from the plant - Inula racemosa Hook. f. exhibited marked in vitro fungistatic activity against this strain of F. solani at 100-200 microgram/ml concentrations. The strain was less sensitive to amphotericin B and showed more acid than alkaline proteinase and phosphatase activities.
D000328:Adult; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification*; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D007783:Lactones / Q000494:pharmacology; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D009947:Organotin Compounds / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011817:Rabbits; D012717:Sesquiterpenes / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology
D000935:Antifungal Agents; D007783:Lactones; D009947:Organotin Compounds; D012717:Sesquiterpenes; D013859:Thiocarbamates; D000666:Amphotericin B; D010744:Phosphoric Monoester Hydrolases; D010447:Peptide Hydrolases