Inhibition of sodium-potassium-activated adenosine 5'-triphosphatase and ion transport by adriamycin.
The antitumor antibiotic Adriamycin is a potent inhibitor of the sodium-potassium-activated adenosine triphosphatase of native heart microsomes. Adriamycin also inhibits potassium transport (although not sodium transport) in slices of kidney cortex. The effects on both the adenosine triphosphatase and ion transport are markedly reduced by Ca2+, probably by chelation of this metal by Adriamycin. These effects could provide a basis for explaining the Adriamycin cardiotoxicity as a digitalis-type toxicity.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004317:Doxorubicin / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D011188:Potassium / Q000378:metabolism*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D004317:Doxorubicin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium