Adrenocorticotropin. 52 Synthesis and biological activity of adrenocorticotropic peptides with cystine bridges.
Three analogs of the amino terminal nonadecopeptide of adrenocorticotropin which incorporate cystine cystine bridges between positions (5, 10), (3, 10), or (2, 10) have been synthesized. All of the peptide analogs showed reduced biological activity; however, the peptide with the 5, 10 cystine bridge was shown to possess significantly higher lipolytic activity in rat fat cells than the peptides with a 3, 10 or 2, 10 cystine bridge.
D000311:Adrenal Glands / Q000032:analysis; D000324:Adrenocorticotropic Hormone / Q000138:chemical synthesis*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis*; D051381:Rats
D000596:Amino Acids; D010455:Peptides; D000324:Adrenocorticotropic Hormone