Coxsackie myocarditis complicating treatment of Hodgkin's lymphoma.
A fatal case of Coxsackie B4 myocarditis complicating treatment of Hodgkin's lymphoma in an adult is reported. The virus was isolated from the myocardium obtained at autopsy and light microscopy confirmed a myocarditis with involvement of the conduction system. Electron-microscopy showed dense mitochondrial inclusions. Coxsackie myocarditis rarely results in death of affected adults. It is postulated in this case that the treatment of the Hodgkin's lymphoma resulted in B lymphocyte depletion, allowing a more virulent infection to occur with resultant fatal myocarditis.
D000328:Adult; D002648:Child; D003384:Coxsackievirus Infections / Q000150:complications* / Q000473:pathology; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D029822:Enterovirus B, Human / Q000302:isolation & purification; D006327:Heart Block / Q000150:complications; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009205:Myocarditis / Q000150:complications* / Q000473:pathology; D010493:Pericarditis / Q000150:complications
D004317:Doxorubicin