Activity of tolmetin on levels of cyclic nucleotides in experimental pleurisy.
Experimental pleurisy induced in rats with an intrapleural injection of 0.2 ml of 2% acetic acid, was used to test the effect of some non-steroidal anti-inflammatory drugs. During the acute phlogistic reaction there is a variation of the cAMP/cGMP ratio, with a sharp increase of the cGMP concentration and a parallel decrease of the cAMP level in the exudate. Indometacin and 1-methyl-5-p-toluoylpyrrole-2-acetic acid (tolmetin, Tolectin), two non-steroidal anti-inflammatory drugs, injected intrapleurally 1 h before the acetic acid injection were able to reduce the inflammatory response, affecting the cAMP and cGMP ratio. That is there is an increase of the cAMP level and a decrease of the cGMP level.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010998:Pleurisy / Q000139:chemically induced / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D014046:Tolmetin / Q000494:pharmacology*
D000085:Acetates; D011758:Pyrroles; D014046:Tolmetin; D000242:Cyclic AMP; D006152:Cyclic GMP; D007213:Indomethacin