[Lipids as possible proton carriers from the respiratory chain to ATP-synthetase and the mechanism of oxidative phosphorylation].
A scheme of oxidative phosphorylation is suggested according to which at the first stage due to the functioning of the electron-transport chain (ETC) in the points of coupling during relaxation of protein non-equilibrium conformation thermodynamically unfavourable transfer of H+ from H2O into the membrane takes place. Athe 2nd stage H+memb is carried by lipids from ETC-protein to ATP-synthetase. At the 3rd stage ATPase with ATP already contained in the active center seizes 2H+. In the course of subsequent protein relaxation the ATP interaction with the active center is disturbed, and ATP with protons transfers to H2O. In terms of the scheme proposed it proves possible to explain the respiratory control and formation of transmembrane potential difference, as well as the action mechanism of uncouplers and inhibitors of oxidative phosphorylation.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D001665:Binding Sites; D002352:Carrier Proteins; D002463:Cell Membrane Permeability; D004579:Electron Transport; D008055:Lipids / Q000502:physiology*; D008564:Membrane Potentials; D008956:Models, Chemical; D009097:Multienzyme Complexes / Q000378:metabolism*; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D011487:Protein Conformation; D011522:Protons; D013816:Thermodynamics
D002352:Carrier Proteins; D008055:Lipids; D009097:Multienzyme Complexes; D011522:Protons; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010770:Phosphotransferases
Lipidy kak vozmozhnye perenoschiki protona ot dykhatel'noĭ tsepi k ATF-sintetaze i mekhanizm okislitel'nogo fosforilirovaniia.