title: Effect of high fluoride intake on haematological aspects of the mouse.
abstract: The effect of feeding adult Swiss albino mice of both sexes a diet supplemented with 0, 125, 250 and 500 parts/10(6) of fluoride for four and eight week periods on haemoglobin concentration (Hb), packed cell volume (PCV) and mean corpuscular haemoglobin concentration (MCHC) was investigated. Values of the three parameters were significantly lowered at both periods in the treated groups as compared with the controls. The extent of reduction in these values was, in general, dependent on the dose of supplemented dietary fluoride. Clinical symptoms were not observed before the end of the sixth week. However, appearance of the symptoms did not change the trend of variations in Hb, PCV and MCHC values. The reduced values could be the result of lowered haemoglobin synthesis and erythropoiesis. It was suggested that these haematological indices could serve to detect preclinical effects of high fluoride intake with an added dose of as low as 125 parts/10(6), or even less, for a period of four weeks or probably earlier.
mesh_terms: D000818:Animals; D001769:Blood / Q000187:drug effects*; D002417:Cattle; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006400:Hematocrit; D006452:Hemoglobinometry; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D005459:Fluorides