Preliminary studies of the mode of action of arildone, a novel antiviral agent.
Arildone (also known as Win 38020), a novel aryl diketone, inhibited replication of herpes simplex virus type 2 in tissue culture by interfering with an event that occurs prior to 6 h postinfection. The inhibition could be partially reversed by washing. Although the exact mechanism of action is unknown, neither viral deoxyribonucleic acid nor viral proteins were synthesized in the presence of arildone.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002499:Centrifugation, Density Gradient; D004247:DNA / Q000096:biosynthesis; D004279:DNA, Viral / Q000096:biosynthesis; D000882:Haplorhini; D066298:In Vitro Techniques; D007659:Ketones / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D018139:Simplexvirus / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004279:DNA, Viral; D007659:Ketones; D014764:Viral Proteins; D012313:RNA; D004247:DNA