title: [Studies on the binding of some parasympatholytics to bovine serum albumin/measurement of relaxation times (author's transl)].
abstract: The interactions of the parasympatholytic drugs adiphenin, adiphenin H and propantheline and the structurally related compounds diphenhydramine, D-propoxyphene and methadone with bovine serum albumin (BSA) are studied by means of 1H-NMR-spectroscopy. The relaxation rates of essential protons or proton groups of the bound ligands are obtained by a plot of the observed relaxation rates, which are determined from the alterations of the line widths in the presence of BSA, versus the biopolymer concentration. From the stabilization factors R thus obtained it can be concluded that there exist defined but relatively weak associations between these drugs and BSA; both the hydrophobic aryl moieties and the ionized amino groups are involved in these interactions.
mesh_terms: D011431:Dextropropoxyphene / Q000378:metabolism; D004155:Diphenhydramine / Q000378:metabolism; D004158:Diphenylacetic Acids / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008691:Methadone / Q000378:metabolism; D010276:Parasympatholytics / Q000378:metabolism*; D011413:Propantheline / Q000378:metabolism; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism*
chemical_list: D004158:Diphenylacetic Acids; D010276:Parasympatholytics; D011413:Propantheline; D012710:Serum Albumin, Bovine; D004155:Diphenhydramine; D011431:Dextropropoxyphene; D008691:Methadone
vernacular_title: Untersuchungen zur Bindung einiger Parasympatholytika an Rinderserumalbumin: Messungen der Relaxationszeiten