Pneumococcal meningitis-therapeutic studies in mice.
A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that have potential therapeutic utility in bacterial meningitis in man. 21 antibiotics, belonging to six major classes were evaluated for efficacy in the experimental infection. The three most active agents proved to be amoxicillin, cephaloridine, and chlortetracycline. Up to this time, amoxicillin has not been commercially available as an injectable dosage form. However, in view of the compound's outstanding efficacy in the present experiments, it would be desirable to investigate its effectiveness in the naturally occurring disease in man.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002701:Chloramphenicol / Q000627:therapeutic use; D002751:Chlortetracycline / Q000627:therapeutic use; D003707:Demeclocycline / Q000627:therapeutic use; D004195:Disease Models, Animal; D004917:Erythromycin / Q000627:therapeutic use; D008034:Lincomycin / Q000627:therapeutic use; D008297:Male; D008586:Meningitis, Pneumococcal / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D010406:Penicillins / Q000627:therapeutic use; D012382:Rolitetracycline / Q000627:therapeutic use; D013296:Streptococcus pneumoniae / Q000472:pathogenicity; D013752:Tetracycline / Q000627:therapeutic use; D014774:Virulence
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D003707:Demeclocycline; D004917:Erythromycin; D002701:Chloramphenicol; D008034:Lincomycin; D013752:Tetracycline; D012382:Rolitetracycline; D002751:Chlortetracycline