[Action of vitamin D and E on the erythrocyte membrane. II. Morphological changes in the erythrocytes studied by transmission electron microscopy].
Man, rabbit, guinea-pig erythrocytes treated "in vitro" with high doses of cholecalcipherol or alpha-tocopherol release K+ and haemoglobin and show ultrastructural damages. These damages consist in a change of the red cells profile as well as in the desappearance of the glycocalix, in alterations of the membrane and of the cortical cytoplasm structure. These ultrastructural alterations are of a different degree, depending on the animal species; they partly resemble the erythrocyte changes induced by retinol. Our results are in partial agreement with the Dingle and Lucy's hypothesis on the common action of liposoluble vitamines on the erythrocyte membrane.
D000818:Animals; D002762:Cholecalciferol / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006168:Guinea Pigs; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008854:Microscopy, Electron; D011188:Potassium / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D006454:Hemoglobins; D014810:Vitamin E; D002762:Cholecalciferol; D011188:Potassium
Azione delle vitamine D ed E sulla membrana eritrocitaria. Nota II. Modificazioni morfologiche degli eritrociti studiate al microscopio elettronico a trasmissione.