Cell-mediated immunity in the uremic rat.
The popliteal node assay of the graft-versus-host reaction in the inbred rat provides a sensitive measure of cell-mediated immunity. Spleen cells from uremic Lewis rats as well as normal cells cultured in uremic serum demonstrated significant immunosuppression which was proportional to the severity of the uremia.
D000818:Animals; D001806:Blood Urea Nitrogen; D002478:Cells, Cultured; D006087:Graft vs Host Reaction; D006648:Histocompatibility; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000276:immunology; D009392:Nephrectomy; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000166:cytology; D014511:Uremia / Q000276:immunology*