Liquoid induced stasis and the generalized Shwartzman reaction. An electron microscopic study in blue foxes.
The composition of the occlusive material within dilated glomerular capillaries, following intravenous injections of Liquoid in blue foxes, was studied electron microscopically; it was found that it mainly consisted of a debris in which disintegrated red cells constituted the major component. Damaged platelets and necrotic endothelial remnants were other components. These observations were interpreted as a result of glomerular stasis, and it was concluded that stasis in glomerular capillaries is a basic event in the development of the renal lesions accompanying the generalized Shwartzman reaction.
D000818:Animals; D005260:Female; D005589:Foxes; D006487:Hemostasis / Q000187:drug effects*; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D008297:Male; D011074:Polyanetholesulfonate / Q000494:pharmacology; D012790:Shwartzman Phenomenon / Q000503:physiopathology*
D011074:Polyanetholesulfonate