title: [Experimental study of the action of the RNAse from Actinomyces rimosus on the variolovaccine virus].
abstract: The effect of Actinomyces rimosus RNAase on the variolovaccine virus was studied. The inhibitory effect of the Actinomyces rimosus RNAase on the variolovaccine virus reproduction in the tissue culture cells was shown. In the experiments with the use of chick embryons and rabbits this effect was less pronounced. A 10 time increase in the infection multiplicity both in the tissue culture and the chick embryons had no noticeable effect on the level of the virus inhibition. It was supposed that the inhibitory effect of the RNAase on the variolovaccine was associated with impairment of the cell metabolism.
mesh_terms: D000818:Animals; D000998:Antiviral Agents; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D012260:Ribonucleases / Q000494:pharmacology*; D013302:Streptomyces / Q000201:enzymology*; D013997:Time Factors; D012901:Variola virus / Q000187:drug effects*; D014776:Virus Cultivation
chemical_list: D000998:Antiviral Agents; D012260:Ribonucleases
vernacular_title: Eksperimental'noe izuchenie deĭstviia RNK-azy Actinomyces rimosus na virus ospavaktsiny.