Cell killing by Simian virus 40: protective effect of chloroquine.
Treatment of CV-1 cells with chloroquine before infection by simian virus 40 resulted in the accumulation of fewer nonviable, trypan blue-stainable cells at 72 h. The drug did not affect the fraction of infected T-antigen-producing cells or the viral yields. It did diminish the apparent redistribution of lysosomal N-acetyl-beta-glucosaminidase from a particulate to a soluble cell fraction, and it caused an increase in the size and number of lysosomes.
D000818:Animals; D002460:Cell Line; D002738:Chloroquine / Q000494:pharmacology*; D000882:Haplorhini; D007668:Kidney / Q000166:cytology*; D008247:Lysosomes / Q000187:drug effects*; D013539:Simian virus 40 / Q000254:growth & development*; D014779:Virus Replication / Q000187:drug effects
D002738:Chloroquine