title: Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons.
abstract: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.
mesh_terms: D000818:Animals; D002450:Cell Communication; D002478:Cells, Cultured; D004553:Electric Conductivity; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology; D008564:Membrane Potentials; D051379:Mice; D009433:Neural Inhibition; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D013373:Substance P / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D013373:Substance P