The relative caries-inhibiting effects of a stannous fluoride dentifrice in a silica gel base.
An unsupervised toothbrushing study involving 1,339 children from 5 to 13 years of age conducted for three years compared two stannous fluoride dentifrices, one in a calcium pyrophosphate base and the other in a silica gel base, with a nonfluoride control dentifrice. The test dentifrice, stannous fluoride in a silica gel base, reduced caries to a significant extent when compared with the nonfluoride control dentifrice.The percentage of reductions ranged from 15% to 25% for whole mouth and interproximal surface indexes. There was no significant difference between the two fluoride dentifrices.
D000293:Adolescent; D002131:Calcium Pyrophosphate / Q000494:pharmacology; D002327:Cariostatic Agents; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control; D003802:Dentifrices / Q000494:pharmacology*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D005782:Gels; D006801:Humans; D008297:Male; D012822:Silicon Dioxide / Q000494:pharmacology; D014002:Tin Fluorides / Q000494:pharmacology*
D002327:Cariostatic Agents; D003802:Dentifrices; D005782:Gels; D014002:Tin Fluorides; D012822:Silicon Dioxide; D005459:Fluorides; D002131:Calcium Pyrophosphate