A critical study on RO-4-1284 antagonism in mice.
Ro-4-1284 is found to produce ptosis, hypothermia, sedation and miosis in mice, and the antagonsim to these symptoms is investigated. The study reports the differential effects of various pharmacologically distinct classes of compounds. The relevance of this type of experiments to possible antidepressant drug activity is discussed.
D012369:2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- / Q000037:antagonists & inhibitors*; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D011807:Quinolizines / Q000037:antagonists & inhibitors*; D013566:Sympathomimetics / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000494:pharmacology
D000700:Analgesics; D000929:Antidepressive Agents, Tricyclic; D000959:Antihypertensive Agents; D006634:Histamine H1 Antagonists; D008996:Monoamine Oxidase Inhibitors; D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; D011807:Quinolizines; D013566:Sympathomimetics; D014149:Tranquilizing Agents; D012369:2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-