Carcinogenic chemicals enhance mouse leukemia virus infection in contact-inhibited culture: a new simple method of screening carcinogens.
Carcinogenic chemicals enhanced infection in contact-inhibited cells with mouse leukemia virus. A correlation was found between the enhancing effects and the carcinogenicities of the 40 chemicals tested. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate did not enhance viral infection.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003260:Contact Inhibition; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D009052:Leukemia Virus, Murine; D051379:Mice; D014779:Virus Replication / Q000187:drug effects
D002273:Carcinogens