title: Tonic immobility in chickens: possible involvement of monoamines.
abstract: Tonic immobility in chickens was affected by a variety of drugs that act on monoaminergic systems. Compounds that enhanced the duration of tonic immobility were d-LSD, BOL-148, pargyline, and iproniazid; 5-hydroxytryptophan, p-CPA, and atropine had no effect. Injections of serotonin depressed response duration. A suggestive parallel was noted between the results of the present study and those of previous work reporting drug-induced suppression of raphe electrical activity. The data appear to implicate monoamines, especially serotonin, in the mediation of behavioral activation and suppression.
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000187:drug effects / Q000502:physiology*; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005239:Fear / Q000502:physiology*; D010134:Fenclonine / Q000494:pharmacology; D007490:Iproniazid / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D009043:Motor Activity / Q000502:physiology*; D009068:Movement / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D011149:Pons / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D011955:Receptors, Drug / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D013045:Species Specificity
chemical_list: D011955:Receptors, Drug; D012701:Serotonin; D001285:Atropine; D008238:Lysergic Acid Diethylamide; D010293:Pargyline; D006916:5-Hydroxytryptophan; D007490:Iproniazid; D010134:Fenclonine