Acquired myeloperoxidase deficiency and recurrent infections in a patient with acute myelomonocytic leukemia.
Acquired myeloperoxidase deficiency has been reported in several hematological malignancies. The clinical course of a patient with acute myelomonocytic leukemia is described which was characterized by staphylococcal infections prior to therapy and again during a period of relapse. Neutropenia was not a feature of these two periods but in vitro studies revealed decreased bacterial killing capacity and decreased neutrophil myeloperoxidase activity. Infectious complications were not observed during drug-induced remission when bacterial killing capacity and myeloperoxidase activity were improved toward normal. These observations suggest that the myeloperoxidase deficient neutrophils were derived from leukemic progenitors.
D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000201:enzymology* / Q000276:immunology; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology; D009195:Peroxidase / Q000097:blood / Q000172:deficiency*; D010544:Peroxidases / Q000172:deficiency*; D013203:Staphylococcal Infections / Q000150:complications*
D010544:Peroxidases; D009195:Peroxidase