[Dynamics of the change in cyclic nucleotide content in wound tissues].
Changes in the content of cyclic nucleotides (cAMP and cGMP) in the wound tissues (muscles and granulations) were studied in experiments on rats. A wound with skin defect in the dorsal area with a crushed underlying muscle served as an experimental model. It was shown that the cAMP content in the muscular tissue rises twice: during the 1st day and to a greater measure on the 7th day. The cGMP content slightly increases on the 1-4th day, drops on the 7th day and increases cAMP concentration changes similarly to that inthe muscular tissue: it increases on the 7th day and drops on the 14th day. On the contrary, the cGMP content curve in granulations is more monotonous, only a slight increase being observed on the 7th day.
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis; D008297:Male; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014945:Wound Healing; D014947:Wounds and Injuries / Q000378:metabolism*
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP
Dinamika izmeneniia soderzhaniia tsiklicheskikh nukleotidov v tkaniakh rany.