[Effect of the characteristics of various alimentary stimuli and changes in the pH of the duodenal content on the acid-forming function of the stomach].
In chronic experiments on dogs the effect of introduction of a non-buffered acid gastric juice into the duodenum or/and of drawing outside the bile via a fistula in the common bile duct on theproduction of hydrochloric acid in innervated ventricles (pouches) was studied. The induced pH shifts in the duodenum were checked every 15 minutes in the duodenal chyme samples. In tests involving meat feeding the reduced pH of the duodenal contents acted not only as an inhibitor of the gastric secretion, but much more as its stimulator. Infusion of the juice into the duodenum, or/and elimination of the bile tended to drastically reduce the inhibitory effect of the fat on the acid-formation in the stomach, this being due to inactivation of the pancreated lipase with HCl and to a defective micellar stage of the intraintestinal transformation of fat. This gives ground to assume that the entrance of acid non-buffered gastric juice into the intestine during transtubal feeding of patients with peptic ulcer is counter-productive in this method of treatment. The application of hyposecretory agents concurrent with the tubal feeding is warranted.
D000818:Animals; D001646:Bile; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology; D004285:Dogs; D004386:Duodenum; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008049:Lipase / Q000378:metabolism; D008460:Meat; D012636:Secretory Rate
D004041:Dietary Fats; D008049:Lipase
Vliianie kachestvenno razlichnykh pishchevykh razdrazhiteleĭ izmeneniia pH soderzhimogo dvenadtsatiperstnoĭ kishki na kislotoobrazovatel'nuiu funktsiiu zheludka