Ergoline derivatives. Note XIII (1) alpha-adrenergic blocking drugs.
The synthesis and the pharmacological activities of 24 analogues of the alpha-adrenergic blocking drug, nicergoline (I b), are reported. The majority of the new compounds were found to be less active than (I b): the structure-activity relationships are presented and discussed.
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis*; D003460:Crystallization; D004952:Esters; D008745:Methylation; D009530:Nicergoline / Q000031:analogs & derivatives / Q000138:chemical synthesis
D000317:Adrenergic alpha-Antagonists; D004952:Esters; D009530:Nicergoline