The effects of burimamide and metiamide on basal gastric function in the cat.
1 Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. 2 Metiamide, in doses which inhibited pentagastrin-stimulated acid secretion, produced no increase in gastric acid secretion in conscious animals, or gastric acid secretion or gastric mucosal blood flow in the anaesthetized cat. 3 Metiamide did not influence the amount of acid which diffused out of the stomach when instilled at pH values between 1.5 and 6.0. 4 The possible mode of action of burimamide in increasing basal gastric secretion is discussed.
D000758:Anesthesia; D000818:Animals; D002049:Burimamide / Q000494:pharmacology*; D002415:Cats; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008785:Metiamide / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013270:Stomach / Q000187:drug effects*; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors
D006634:Histamine H1 Antagonists; D008785:Metiamide; D013890:Thiourea; D002049:Burimamide