title: Histiocytosis X. III. Clinical value of serial biopsies.
abstract: In a retrospective review of sequential biopsies in 8 cases of histiocytosis X, 2 developed xanthomatous or fibrous lesions, 3 remained unchanged, whereas 3 developed malignant disease, one Hodgkin's disease and 2 malignant histiocytosis. A possible progression from benign, well differentiated to malignant histiocytic lesion is discussed, and the importance of achieving a microscopic diagnosis is emphasized.
mesh_terms: D000328:Adult; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D002675:Child, Preschool; D004817:Epidermis / Q000473:pathology; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology