Humoral immunity to a metabolite of halothane, fluroxene, and enflurane.
Trifluoroacetate, a common metabolite of halothane, fluroxene, and enflurane, conjugated to guinea-pig albumin elicits specific serum antibody in guinea pigs. Two classes of antibodies were found: hemolytic, gamma-2, and anaphylactic, gamma-1. Repeated injections of the antigen, trifluoroacetyl-guinea pig albumin, often led to disappearance of circulating antibodies.
D000818:Animals; D000917:Antibody Formation; D003168:Complement Fixation Tests; D004737:Enflurane / Q000378:metabolism*; D004987:Ethers / Q000378:metabolism*; D005463:Fluoroacetates / Q000276:immunology*; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006168:Guinea Pigs / Q000276:immunology; D006221:Halothane / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D006968:Hypersensitivity, Delayed; D007109:Immunity; D007075:Immunoglobulin M / Q000032:analysis; D007271:Injections, Intradermal; D007275:Injections, Intravenous; D008297:Male; D008623:Mercaptoethanol / Q000494:pharmacology; D008738:Methyl Ethers / Q000378:metabolism*; D010323:Passive Cutaneous Anaphylaxis; D012709:Serum Albumin / Q000008:administration & dosage; D012882:Skin Tests; D014269:Trifluoroacetic Acid / Q000008:administration & dosage / Q000276:immunology*
D004987:Ethers; D005463:Fluoroacetates; D007075:Immunoglobulin M; D008738:Methyl Ethers; D012709:Serum Albumin; D008623:Mercaptoethanol; D005620:Freund's Adjuvant; D004737:Enflurane; D014269:Trifluoroacetic Acid; D006221:Halothane