On the effects of thiamphenicol and chloramphenicol on nucleic acid and protein synthesis in rabbit bone marrow cells in vivo and in vitro.
Besides the in vivo effects of thiamphenicol (TAP), this study shows the in vitro effects of TAP and D- and L-threo-chloramphenicol (CAP) on the synthesis of DNA, RNA, protein and hemoglobin in marrow cells and reticulocytes. The experiments make it likely that TAP exerts its action on a stem cell in a proliferating phase.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D002701:Chloramphenicol / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D003576:Electron Transport Complex IV / Q000378:metabolism; D006454:Hemoglobins / Q000096:biosynthesis; D066298:In Vitro Techniques; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D013237:Stereoisomerism; D013839:Thiamphenicol / Q000494:pharmacology*; D013997:Time Factors
D006454:Hemoglobins; D012313:RNA; D002701:Chloramphenicol; D004247:DNA; D003576:Electron Transport Complex IV; D013839:Thiamphenicol