Growth failure, somatomedin and growth hormone levels in juvenile diabetes mellitus--a pilot study.
Growth hormone (hGH) responsiveness to exercise and somatomedin C (SmC) activity were measured in ten children with insulin-deficient diabetes mellitus. Four of the ten children showed a significant degree of growth retardation. Normal SmC activity was found in association with elevated hGH levels. The hypothesis that growth-retarded diabetics have a failure of Sm production despite high hGH levels (analogous to malnutrition and Laron dwarfism) was not substantiated by this study. Chronic deficiency of insulin, itself a somatomedin, may play a major role in diabetic growth failure.
D000293:Adolescent; D000365:Age Determination by Skeleton; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000150:complications*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D010865:Pilot Projects; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D013006:Growth Hormone