Cyclic AMP and its functional relationship in Tetrahymena: a comparison between phagocytosis and glucose uptake.
In Tetrahymena, an increase in the level of cAMP is accompanied by an increased phagocytotic rate, whereas increased sugar uptake is parallelled by a decreased cAMP level. The increase in cAMP level seems to be decisive with respect to phagocytosis as a basic phenomenon of life. In the action of epinephrine, however, some mechanism other than cAMP mediation may be involved. Depending on concentration, one hormone may provoke either an increase or a decrease in cAMP level, and this in turn triggers the corresponding function.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D013769:Tetrahymena pyriformis / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013806:Theophylline / Q000494:pharmacology
D012701:Serotonin; D013806:Theophylline; D000242:Cyclic AMP; D005947:Glucose; D004837:Epinephrine