title: Peripheral neuropathy in lead-intoxicated sickle cell patients.
abstract: Peripheral neuropathy and hypertension caused by lead intoxication are reported in two children with sickle cell anemia. One child had generalized weakness in the initial occurrence and distal paralysis during a relapse two years later. The second child had foot and wrist drop. Both had slow peripheral nerve conduction velocities during the episodes. Chelation therapy was successful and resulted in a return of strength (over a period of several months) and a normalization of the blood pressures. Children with sickle cell anemia who are subjected to lead intoxication appear to be predisposed to peripheral nerve damage.
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007855:Lead Poisoning / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010243:Paralysis / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
chemical_list: D004492:Edetic Acid