[Development of new types of chemical vaccine for prevention of intestinal infections and problems of their qualitative evaluation. III. Comparative study of immunologic characteristics of experimental antigenic preparations].
As a result of comparative study of the immunological properties and antigenic activity of thyphoid, paratyphoid A and B and Sonne and Flexner dysentery antigenic preparations obtained by various methods there was revealed a decreased toxicity of the experimental preparations of the Tashkent and Leningrad Institute of Vaccines and Sera (in comparison with the tryptic antigens) and a considerable advantages of the experimental thyphoid and paratyphoid antigenic preparations by their capacity to induce the H-antibody formation in the presence of the O-antigenic activity. The preparations of the Moscow Institute of Vaccines and Sera had increased toxicity. The detected advantages of the experimental antigenic preparations of the Tashkent and Leningrad Institute of Vaccines and Sera permitted to recommend the method used in their making to obtain new chemical vaccines against the intestinal infections.
D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000633:toxicity; D005407:Flagella / Q000276:immunology; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D012482:Salmonella paratyphi A / Q000276:immunology*; D012484:Salmonella paratyphi B / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D012763:Shigella flexneri / Q000276:immunology*; D012764:Shigella sonnei / Q000276:immunology*
D000942:Antigens, Bacterial
Konstruirovanie novykh tipov khimicheskikh vaktsin dlia profilaktiki kishecyhykh infektsii i voprosy ikh kachestvennoĭ otsenki. Soobshchenie III. Immunologicheskaia kharakteristika éksperimental'nykh antigennykh preparatov, predstavlennykh dlia sravitel'nogo izucheniia