The value of levamisole in a Wilms' tumor animal model.
The effect of Levamisole was studied in an animal model of Wilms' tumor. No tumoridical effect of Levamisol could be documented in this tumor model, and no effect was shown on prevention of tumor, when Levamisole was given before tumor implantation. In previous experience with Wilms' tumor model, a good correlation between the human and animal tumor was found in regard to treatment with different drugs. The fact that Levamisole had no effect on our animal model and its reported immunosuppressive effect at some doses, should be considered in planning clinical trials.
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007680:Kidney Neoplasms / Q000188:drug therapy*; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D011920:Rats, Inbred WF; D009396:Wilms Tumor / Q000188:drug therapy*
D007978:Levamisole