[Hematological manifestations and complications in Sjögren's syndrome (author's transl)].
The main hematological manifestations and complications seen in 18 cases of Sjögren's syndrome are described: a slight anemia of the inflammatory type, a leucopenia, and/or an eosinophilia occur in about half of the patients. One case of auto-immune hemolytic anemia, one of pernicious anemia, 3 of hypoplastic anemia--one of them drug-induced--, and one of thrombocytopenic purpura have also occurred. The clinical and biological manifestations related to the disturbed immunologic status are also frequent: hyperglobulinemic purpura. Raynaud's syndrome due to cryoglobulinemia, rheumatoid factor, anti-nuclear factor. In 4 patients, the disease presented with or evolved into lymphadenopathy and/or splenomegaly; the initial "pseudo-lymphoma" diagnosis corresponded to different aspects or courses: in one cases, malignancy appeared soon, another has evolved in a chronic lympho-proliferative disease, a third one had the histologic features of angio-immunoblastic lymphadenopathy. These various manifestations, which may reveal the Sjögren's syndrome, are discussed in the light of the litterature data.
D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology*; D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex; D004802:Eosinophilia / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D007970:Leukopenia / Q000209:etiology*; D008232:Lymphoproliferative Disorders; D008297:Male; D008875:Middle Aged; D011694:Purpura, Hyperglobulinemic / Q000209:etiology; D011928:Raynaud Disease / Q000209:etiology; D012217:Rheumatoid Factor / Q000032:analysis; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D012217:Rheumatoid Factor
Manifestations et complications hématologiques du syndrome de Sjögren.