Ocular penetration of pilocarpine: the effect of pH on the ocular penetration of pilocarpine.
Under the conditions of this study, tritiated pilocarpine was topically applied to rabbits, and the activity in the aqueous humor was measured at selected times. It was found that higher pH affords greater pilocarpine penetration. At pH 7.5, for example, penetration into the aqueous was twice as great as at pH 4.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D003315:Cornea / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors; D014316:Tritium
D009883:Ophthalmic Solutions; D010862:Pilocarpine; D014316:Tritium