Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes.
This study reports the in vitro influence of morphine, dextromoramide, levomoramide, and methionine-enkephalin upon normal human T blood lymphocytes by using the active and total rosette tests. Morphine and dextromoramide inhibited the percentage of active T rosettes. This effect was completely reversed in the presence of naloxone, their specific antagonist. The specificity was further demonstrated by the absence of the effect of levomoramide, the inactive enantiomere, upon the rosette system. Methionine-enkephalin increased the percentage of active T rosettes. This effect was specifically inhibited by naloxone. These observations suggest that normal human blood T lymphocytes bear surface receptor-like structures for morphine, dextromoramide, and methionine-enkephalin. Such findings may provide a link between the central nervous system and the immune system.
D001665:Binding Sites; D003916:Dextromoramide / Q000276:immunology; D004723:Endorphins / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008715:Methionine / Q000378:metabolism; D009270:Naloxone / Q000494:pharmacology; D011955:Receptors, Drug / Q000276:immunology*; D011957:Receptors, Opioid / Q000276:immunology*; D012397:Rosette Formation; D013237:Stereoisomerism; D013601:T-Lymphocytes / Q000276:immunology*
D004723:Endorphins; D004745:Enkephalins; D011955:Receptors, Drug; D011957:Receptors, Opioid; D009270:Naloxone; D003916:Dextromoramide; D008715:Methionine