[Interrelationship between metabolic and genetic regulation of alkaline phosphatase and poly- and pyrophosphatases].
The effects of orthophosphate and mutations in the regulatory genes of alkaline phosphatase on the activities of pyrophosphatase and polyphosphatase of E. coli were studied. It was shown that orthophosphate represses the synthesis of alkaline phosphatase as well as that of polyphosphatase without having any effect on pyrophosphatase. The genes phoR and phoS are involved in the formation of a repressory complex both for alkaline phosphatase and polyphosphatase. The gene phoT is probably involved in a partial repression of pyrophosphatase synthesis.
D017766:Acid Anhydride Hydrolases; D000469:Alkaline Phosphatase / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D005809:Genes, Regulator; D009154:Mutation; D010710:Phosphates / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism*; D011122:Polyphosphates; D011755:Pyrophosphatases / Q000378:metabolism; D013489:Suppression, Genetic
D010710:Phosphates; D011122:Polyphosphates; D000469:Alkaline Phosphatase; D010744:Phosphoric Monoester Hydrolases; D017766:Acid Anhydride Hydrolases; D011755:Pyrophosphatases; C022563:endopolyphosphatase
Izuchenie vzaimosviazi metabolicheskoĭ i geneticheskoĭ reguliatsii shchelochnoĭ fosfatazy s poli- i pirofosfatazami.