title: Regional ketamine-induced depression of neuromuscular transmission in man.
abstract: The intravenous injection of ketamine in the human arm with isolated circulation, using the same technique as for intravenous regional anesthesia, produces a dose-related depression of neuromuscular transmission, as evidenced by the evoked response to supramaximal stimulation of the ulnar nerve with a nerve stimulator. The dose range of ketamine was 200, 25, 10, 5, 1, 0.5 and 0.25 mg, in 20 ml of 5% dextrose in water. The exact mechanism of this effect is discussed. This depression may have clinical significance under certain circumstances.
mesh_terms: D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D009407:Nerve Block; D009435:Synaptic Transmission / Q000187:drug effects*; D014459:Ulnar Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D007649:Ketamine