[Enzymatic digestibility of peptides containing tert-butyltryptophan residues (author's transl)].
The effects of tert-butylation of tryptophan residues in peptide chains on the enzymatic digestibility were investigated. It was shown that replacement of tryptophan in position 9 of Corticotropin-(1--19)-nonadecapeptidamide by a mono- or tri-tert-butylated tryptophan enhances the resistance of the resulting analogue against proteolytic enzymes.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000626:Aminopeptidases; D002918:Chymotrypsin; D013379:Substrate Specificity; D014357:Trypsin; D014364:Tryptophan / Q000031:analogs & derivatives*
D014364:Tryptophan; D000324:Adrenocorticotropic Hormone; D000626:Aminopeptidases; D002918:Chymotrypsin; D014357:Trypsin
Untersuchungen über den enzymatischen Abbau von tert-Butyltryptophan-haltigen Peptiden.