[Cyclic GMP in the eye and its correlation with externally administered insulin].
Experiments carried on Albino rabbits for detecting cyclic GMP in the eye tissues and to observe whether cGMP is influenced through local administration of insulin to the eye, externally. Whereas, for instance, intraveinous administration of insulin does not influence, in any way, concentration of cGMP -- after 3' to 10' -- in the humour aqueous, the lens, the vitreous body and the blood serum, following administration of insulin by means of retrobulbar injection, for the same time and on the same tissues, the values of cGMP appear increased. On the other hand, results yielded by our experiments allow us to estimate that environment preparing cGMP in the eye is the retina and the choroid.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D002829:Choroid / Q000378:metabolism; D006152:Cyclic GMP / Q000097:blood / Q000378:metabolism*; D005123:Eye / Q000187:drug effects / Q000378:metabolism*; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism
D007328:Insulin; D006152:Cyclic GMP
Le cGMP dans l'oeil et sa corrélation avec l'insuline administrée par voie externe.