[Preliminary data on activation of the enzyme of the metabolism of phospholipid bases in various areas of the brain].
The scope of this work was to study the effect of imydazole on base-exchange enzymic system in selected cerebral areas. We have previously demonstrated that imydazole was an activator of phosphatidylserine synthesis in slices of caudate nucleus. This effect lacked in the omogenate we had supposed that this activation by imydazole was not directed on base-exchange enzymic system, but was induced by decrease of cellular cyclic nucleotides amount. Therefore we have investigated the effect of dibutirril-AMPciclic in selected cerebral areas. In addition it was useful to state if activation by imydazole was area-specific or not.
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D003994:Bucladesine / Q000494:pharmacology*; D004789:Enzyme Activation; D007093:Imidazoles / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000096:biosynthesis; D010718:Phosphatidylserines / Q000096:biosynthesis; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D007093:Imidazoles; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D010743:Phospholipids; D003994:Bucladesine
Dati preliminari sull'attivazione dell'enzima dello scambio delle basi fosfolipidiche in varie aree cerebrali.