Neonatal diagnosis of Fredrickson type II hyperlipoproteinaemia.
Cord-serum beta-lipoprotein was measured by an immunological method in 303 children. The blood lipids were studied at 7-9 and 14-19 months after birth. The lipids of both parents were measured. Six children were found to have a greater than 2 SD elevation of beta-lipoprotein at birth. Three of these had hypertriglyceridaemia and 3 had type II hyperlipoproteinaemia. The rapid and quantitative measurement of beta-lipoprotein looks promising for screening of type II hyperlipoproteinaemia at birth.
D006801:Humans; D006937:Hypercholesterolemia / Q000175:diagnosis; D006949:Hyperlipidemias / Q000175:diagnosis*; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D013577:Syndrome; D014280:Triglycerides / Q000097:blood
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides