Immunopathological mechanisms in rheumatoid arthritis at the dual interface of the synovial membrane: the joint cavity and the pannus.
The significance of immune responses is examined in relation to clinicopathological changes in the rheumatoid joint and the concept of a dual site of action is developed. In the joint cavity interaction between immune complexes and complement is central to the phenomena observed, which depend on the generation of chemotactic factors and the ingress of polymorphs. Other chemical mediators--e.g. prostaglandins and lymphokines--are envisaged as playing a secondary or augmentory role. At the pannus-cartilage (and bone) junction the possibility is considered that changes are due to activation of a variety of cell types which results in enzymatic degradation of collagen in cartilage, osteolastic activity in bone and prostaglandin-induced depletion of bone. The production of migration inhibition factors by rheumatoid membranes is examined and some evidence in support of their lymphokine nature is found by gel filtration; their role as cell activators is considered.
D000936:Antigen-Antibody Complex; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D001183:Arthus Reaction / Q000150:complications; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003165:Complement System Proteins / Q000096:biosynthesis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000096:biosynthesis; D007596:Joints / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis / Q000494:pharmacology; D003012:Microbial Collagenase / Q000378:metabolism; D012217:Rheumatoid Factor / Q000032:analysis; D013582:Synovial Fluid / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology* / Q000378:metabolism
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003182:Complement C5; D007074:Immunoglobulin G; D007136:Immunoglobulins; D008222:Lymphokines; D003165:Complement System Proteins; D012217:Rheumatoid Factor; D003012:Microbial Collagenase