Leucocyte function in iron-deficiency anemia.
Production of hydrogenperoxide and myeloperoxidase-mediated iodination, by leucocytes was studied in normal subjects and subjects suffering from iron-deficiency anemia. The leucocytes obtained from severe cases of iron-deficiency anemia showed decreased myeloperoxidase-mediated iodination. Defective myeloperoxidase-mediated iodination can explain the basis for the leucocyte microbicidal defect in iron deficiency anemia.
D000747:Anemia, Hypochromic / Q000276:immunology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007455:Iodine / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D009195:Peroxidase / Q000378:metabolism
D007455:Iodine; D006861:Hydrogen Peroxide; D009195:Peroxidase