title: Ultrastructural organization of thrombocytes in normal monkeys (Macaca arctoides) and in those with experimental viral malignant lymphoma.
abstract: Data on platelet ultrastructure of 6 M. arctoides monkeys investigated before and during experimental viral malignant lymphoma are presented. It has been established that the inner structure of thrombocytes in healthy monkeys was almost similar to that of man. In experimental malignant lymphoma, irrespective of the clinical period of the disease, a decrease of alpha-, beta- and sigma-granules, a decrease of the functional activity of thrombocytes and an increase of delta-granules and glycogen granulation content were observed. The above mentioned disturbances can be a result of changes of megakaryocytes in malignant lymphoma. No viral particles in thrombocytes of neither healthy nor sick monkeys have been revealed.
mesh_terms: D000818:Animals; D001769:Blood / Q000382:microbiology; D001792:Blood Platelets / Q000648:ultrastructure*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D000882:Haplorhini; D006801:Humans; D008223:Lymphoma / Q000097:blood* / Q000209:etiology; D008251:Macaca; D008297:Male; D012190:Retroviridae