[Study of the mutagenic activity of mazheptil].
Mutagenic activity of the psychotropid drug--majeptil was studied. Majeptil does not induce gene mutations on Salmonella typhimurium and chromosomal aberrations in mice bone marrow cells in vivo. It is shown that majeptil increase the level of chromosome aberrations in the culture of human peripheral blood lymphocytes. It is also active in the dominant lethal test on mice.
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D005260:Female; D005796:Genes / Q000187:drug effects; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008938:Mitosis; D009154:Mutation / Q000187:drug effects*; D010640:Phenothiazines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013997:Time Factors
D010640:Phenothiazines
Izuchenie mutagennoĭ aktivnosti mazheptila