[Effect of hemodialysis on erythrocyte acetylcholinesterase and adenosine triphosphatase activity in chronic renal insufficiency].
Erythrocytes of patients with chronic kidney insufficiency exhibited high hexokinase activity as well as low activity of acetylcholinesterase and K+, Na+-dependent ATPase. The Km value of acetylcholinesterase for acetyl thiocholine was not altered in the reaction and the enzyme proved to be more resistant to heat denaturation. Therapy with permanent hemodialysis [8-10 hrs per day within some months] normalized K+, Na+-dependent ATPase activity and activated acetylcholinesterase. These effects may be considered as evidence for detoxication and normalization of metabolism. At the same time, high hexokinase activity and increased resistance of acetylcholinesterase to heat inactivation were maintained.
D000110:Acetylcholinesterase / Q000097:blood*; D000251:Adenosine Triphosphatases / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000201:enzymology; D002908:Chronic Disease; D004789:Enzyme Activation; D004912:Erythrocytes / Q000201:enzymology*; D005921:Glomerulonephritis / Q000201:enzymology; D006593:Hexokinase / Q000097:blood; D006801:Humans; D006977:Hypertension, Renal / Q000201:enzymology; D007676:Kidney Failure, Chronic / Q000201:enzymology*; D008875:Middle Aged; D006435:Renal Dialysis; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D006593:Hexokinase; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie gemodializa na aktivnost' atsetilkholinésterazy i adenozintrifosfatazy éritrotsitov pri khronicheskoĭ pochechnoĭ nedostatochnosti.