Anion dependence of the contractions of skinned cardiac cells.
Cardiac muscle fragments with disrupted sarcolemmas were prepared by homogenization of mouse ventricles. The rate of spontaneous contractions was increased when a solution containing isobutyrate as the main anion was substituted with a solution rich in chloride. At low calcium concentrations preparations which were quiescent in the isobutyrate solution responded to the chloride with a strong single contraction.
D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008698:Mesylates / Q000494:pharmacology; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology
D002087:Butyrates; D002712:Chlorides; D008698:Mesylates; D011422:Propionates