Mutagenicity of chamuvaritin: a benzyldihydrochalcone isolated from a medicinal plant.
The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal enzyme preparation.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D002599:Chalcone / Q000031:analogs & derivatives / Q000633:toxicity*; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced; D008519:Medicine, Traditional; D008862:Microsomes, Liver / Q000201:enzymology; D009153:Mutagens; D009154:Mutation; D009549:Nigeria; D010946:Plants, Medicinal; D011427:Propiophenones / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014966:Xanthenes
D009153:Mutagens; D011427:Propiophenones; D014966:Xanthenes; D002599:Chalcone; C022798:chamuvaritin