title: Nature of the acidifying defect after the relief of ureteral obstruction.
abstract: Nature of the acidifying defect observed after relief of ureteral obstruction. The acidifying capacity of the normal and experimental kidney was studied in rats three hours after release of complete unilateral ureteral obstruction or after unilateral release of unilateral ureteral obstruction,  mean plasma bicarbonate concentration was 23.5 mEq/liter, and plasma pH, 7.45. Urine pH from the postreleased kidney was 7.47 and 6.01 from the control side. Net acid escretion averaged 0.97 muEq/min in the experimental kidney. Fractional excretion of bicarbonate averaged 0.02% in the control and 3.17% in the experimental kidney. In eight animals with unilateral release of bilateral ureteral obstruction, mean plasma bicarbonate was 16.9 mEq/min and plasma pH was7.35. Mean urine pH in the postreleased Kidney was 6.11, net acid excretion averaged 2.01 plus or minus 0.69 muEq/min and fractional bicarbonate excretion averaged 0.84%.
mesh_terms: D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000097:blood* / Q000652:urine; D002245:Carbon Dioxide; D005260:Female; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007686:Kidney Tubules, Distal / Q000187:drug effects; D008026:Ligation; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009399:Nephrons / Q000187:drug effects; D010313:Partial Pressure; D051381:Rats; D013997:Time Factors; D014517:Ureteral Obstruction / Q000503:physiopathology*
chemical_list: D001639:Bicarbonates; D000643:Ammonium Chloride; D002245:Carbon Dioxide