Stimulation of cyclic AMP phosphodiesterase activity by the heated supernatant fraction of canine tracheal smooth muscle.
The cAMP-hydrolyzing activity (phosphodiesterase) in the supernatant fraction of canine tracheal smooth muscle was approximately doubled by addition of more concentrated, heat-treated tissue extract. The activation was eliminated by EDTA, but addition of calcium produced no greater activation than addition of heated extract alone. It appears that canine tracheal smooth muscle phosphodiesterase can be activated by a heat-stable, calcium-dependent factor.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D005260:Female; D006358:Hot Temperature; D009130:Muscle, Smooth / Q000201:enzymology*; D014132:Trachea / Q000201:enzymology*
D015105:3',5'-Cyclic-AMP Phosphodiesterases