title: Blood pressure response to both carotid occlucion and asphyxia, as influenced by intracerebroventricular injection of norepinephrine or epinephrine.
abstract: The carotid occlusion response (COR) in dogs was inhibited by 50 and 58% after intracerebroventricular injection of norepinephrine and hydrochloric acid, both at the pH 2.9. After norepinephrine at pH 7, this inhibition was 22%. The COR inhibition was 24% with epinephrine solution of pH 2.4 whereas the same solution at pH 7 produced no inhibition. The injection of drugs solved in acid solution, lead to a decrease in the pH of the cerebrospinal fluid. The response to asphyxia was inhibited by 50% after injection of norepinephrine at pH 2.9, but not after epinephrine at pH 2.4 or hydrochloric acid. Bradycardia was caused by epinephrine in neutral or acid solution and a decrease of arterial blood pressure was seen after epinephrine or norepinephrine in neutral or acid solution.
mesh_terms: D000818:Animals; D001237:Asphyxia; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries / Q000502:physiology*; D003864:Depression, Chemical; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006851:Hydrochloric Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*
chemical_list: D006851:Hydrochloric Acid; D009638:Norepinephrine; D004837:Epinephrine