[Benign neurologic accident following anti-rabies vaccination. Unforeseen clinical and biological aspects].
A minor and benign encephalitogenic reactions was observed in the days following administration of suckling mouse brain anti-rabies vaccine. The syndrome appeared at the 18th day of the treatment, undertaken according to Gamet and Atanasiu's shortened treatment schedule. Recovery occured without sequellae after 5 days of corticosteroid therapy. Compared to the reports of the literature, the benignity of the central nervous system involvement was unexpected. Three immunological problems are stressed out: the presence of sheep anti-red blood cells antibodies after antirabies vaccines; the presence of antismooth muscle antibodies; a previous BCG vaccination one month before antirabies treatment might play an adjuvant participation.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000937:Antigen-Antibody Reactions; D001500:BCG Vaccine / Q000008:administration & dosage; D001921:Brain / Q000276:immunology; D002648:Child; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D009132:Muscles / Q000276:immunology; D011819:Rabies Vaccines / Q000009:adverse effects*; D012756:Sheep
D000305:Adrenal Cortex Hormones; D001500:BCG Vaccine; D011819:Rabies Vaccines
Accident neurologique benin apres vaccination antirabique. Aspects cliniques et biologiques inattendus