[Effect of phosphorus on polymyxin B biosynthesis by B. polymyxa 1538 on media of varying makeup].
The effect of phosphorus on biosynthesis of polymyxin B by B. polymyxa 1538 was studied and its optimal concentration in the synthetic and two complex media was determined. Correlation between the culture growth and consumption of the main components, on the one hand, and concentration of phosphorus in the medium, on the other hand, was found. It was shown that the effect of phosphorus on biosynthesis of polymyxin B did not depend on the carbon source in the medium and aeration conditions.
D001407:Bacillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D010758:Phosphorus / Q000378:metabolism*; D011112:Polymyxin B / Q000096:biosynthesis*; D011113:Polymyxins / Q000096:biosynthesis*
D003470:Culture Media; D011113:Polymyxins; D010758:Phosphorus; D002244:Carbon; D011112:Polymyxin B
Vliianie fosfora na biosintez polimiksina B B. Polymyxa 1538 na sredakh razlichnogo sostava.