Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique.
Spray drying techniques have been applied to improve the solubility and dissolution rate of poorly water-soluble salicylic acid. Spray drying of the acid dispersed in acacia solutions resulted in as much as a 50% improvement in the solubility of the product. Solubility improvement was closely related not only to the concentration of acacia but also the amount of amorphous material in the spray-dried products. The heat of solution was inversely related to these parameters. The dissolution rate of spray-dried product was almost instantaneous being about 60 times faster than that of the original powder. A great improvement in the wettability of the spray-dried material seemed to be mainly responsible for the increase of dissolution rate.
D004058:Diffusion; D008722:Methods; D010316:Particle Size; D011208:Powders; D012459:Salicylates; D012995:Solubility; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors; D014867:Water; D014961:X-Ray Diffraction
D011208:Powders; D012459:Salicylates; D014867:Water