The relationship between Ca2+-mediated polyphosphoinositide phosphodiesterase activity, 1, 2-diacylglycerol accumulation, and microvesiculation in erythrocytes.
A variety of morphologic and metabolic changes occur in erythrocytes in which the intracellular level of Ca2+ is increased. These include echinocytosis followed by microvesiculation, K+ efflux, ATP degradation, and activation of polyphosphoinositide phosphodiesterase with the formation of 1,2-diacylglycerol and phosphatidate. The relationships between these changes are discussed and an attempt is made to assess their significance in both normal and aged cells.
D000255:Adenosine Triphosphate / Q000097:blood; D002118:Calcium / Q000494:pharmacology*; D002470:Cell Survival; D004075:Diglycerides / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D005989:Glycerides / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D010716:Phosphatidylinositols / Q000097:blood; D010727:Phosphoric Diester Hydrolases / Q000097:blood*; D011188:Potassium / Q000097:blood
D004075:Diglycerides; D005989:Glycerides; D010716:Phosphatidylinositols; D000255:Adenosine Triphosphate; D010727:Phosphoric Diester Hydrolases; D011188:Potassium; D002118:Calcium