title: [Dovenix and Acedist residues in the tissues and organs of guinea pigs and their effects on biochemical blood indices].
abstract: It was established that the antihelminth preparations dovenix and acedist are deposited in all inner organs and muscle tissues of laboratory animals (guinea-pigs) treated once with doses 0.1 cm by injection and 100 mg per os. Residual quantities of the named antihelminth preparations were found on the 6th to 57th day post treatment in the liver, lung, heart, kidneys, spleen and muscles. On the 61st day no residual quantities of the preparations were assessed in the muscles and inner organs. The hematological investigations and proteinogramms of experimental animals treated with dovenix and acedist do not reveal significant changes. In guinea-pigs treated with acedist a certain reduction of the beta- and gamma-globulin fractions is observed, while in those treated with dovenix the beta-globulin fractions are reduced.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000032:analysis* / Q000378:metabolism; D001713:Biphenyl Compounds / Q000032:analysis*; D001769:Blood / Q000187:drug effects*; D001798:Blood Proteins / Q000032:analysis; D004338:Drug Combinations / Q000032:analysis / Q000378:metabolism; D006168:Guinea Pigs; D009596:Nitrophenols / Q000032:analysis* / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000032:analysis* / Q000378:metabolism; D011075:Polybrominated Biphenyls / Q000032:analysis* / Q000378:metabolism; D013012:Sorbitol / Q000032:analysis* / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000871:Anthelmintics; D001713:Biphenyl Compounds; D001798:Blood Proteins; D004338:Drug Combinations; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D011075:Polybrominated Biphenyls; C023620:Trodax; D013012:Sorbitol; C018474:bromophenophos
vernacular_title: Ostatuchni kolichestva doveniks i atsedist v tukani i organi na morski svincheta i vliianieto im vurkhu niakoi biokhimichni pokazateli na kruvta.