Influences of an analog of the neuropeptide ACTH 4--9 on mentally retarded adults.
In a double-blind procedure, 24 mentally retarded adults received 0 mg, 5mg, or 20 mg of an analog of the neuropeptide ACTH 4--9. Following treatment with peptide, the subjects were given the Trails B Test (from the Halstead-Reitan Neuropsychological Battery), the Peabody Picture Vocabulary test, the Benton Visual Retention Test, a concept-formation task, and a standard orienting sequence. The results of the behavioral tests suggested that attentional processes were enhanced in subjects treated with the peptide. The present study, in conjunction with another investigation using the neuropeptide ACTH/MSH 4--10 (Sandman, George, Walker, Nolan & Kastin, 1976), indicates that attentional deficits in mentally retarded adults, traditionally assumed to be irreversible, may be influenced by treatment with fragments of the neuropeptides ACTH and MSH.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D001288:Attention / Q000187:drug effects*; D003210:Concept Formation / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy*; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011581:Psychological Tests; D012193:Reversal Learning / Q000187:drug effects
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone