Stimulation of the alpha-and beta-adrenergic receptors in human ovarian vasculature in vitro.
The effect of fenoterol and norepinephrine was studied on the vascular resistance of in vitro perfused human ovary. It was found that the beta-adrenergic stimulant fenoterol causes vasodilatation, whereas the alpha-adrenergic stimulant norepinephrine elicits vasoconstriction in the arterial vascular bed of the ovary showing the role of adrenergic mechanism in the regulation of ovarian blood flow. It was supposed that therapeutical administration of beta-mimetic drugs leads to the elevation of ovarian blood flow, which may have special importance in the case of corpus luteum insufficiency.
D000328:Adult; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology*; D010053:Ovary / Q000098:blood supply* / Q000187:drug effects; D011247:Pregnancy; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D004983:Ethanolamines; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D005280:Fenoterol; D009638:Norepinephrine