Centrally induced hypotension unreleated to alpha-adrenergic stimulation.
Central hypotension is induced by erythro-1-(1-[2-(1,4 - benzodioxan - 2 - yl) - 20H - ET] - 4 - piperidyl) - 2 - benzimidazolinone (R28935), as evidenced by local injections into the cisterna magna of anaesthetized dogs. This hypotensive effect is not inhibited by piperoxan, 100 mug/kg s.o. R28935, contrary to clonidine or norepinephrine, does not provoke vasoconstriction in the perfused isolated artery of the rabbit ear. Very low doses of R28935 antagonize vasoconstriction induced by KC1-depolarization. The centrally-induced hypotension is not due to alpha-adrenergic stimulation.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects; D001562:Benzimidazoles / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology; D003864:Depression, Chemical; D004146:Dioxanes / Q000494:pharmacology; D004285:Dogs; D004423:Ear / Q000098:blood supply; D007022:Hypotension / Q000139:chemically induced*; D009638:Norepinephrine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D000316:Adrenergic alpha-Agonists; D001562:Benzimidazoles; D004146:Dioxanes; D010880:Piperidines; D003000:Clonidine; D009638:Norepinephrine