title: The assessment of acid-base disturbance in man by the use of carbon dioxide titration curves.
abstract: 1. Carbon dioxide titration curves were determined in vivo in dog and man at various degrees of acute non-respiratory acidaemia and alkalaemia. 2. The slope of the CO2 titration curve (delta log Pco2/delta pH) was found to increase with the severity of the acute non-respiratory alkalaemia the slope (delta log Pco2/delta pH) tended towards unity. 3. A simple scheme based on the CO2 titration curves determined in vivo has been proposed for the assessment of acute acid-base disturbances in man. 4. Carbon dioxide titration curves were also determined in vivo in patients with chronic respiratory and non-respiratory acidaemia and it was found that these curves were not significantly different from those obtained in states of acute acid-base disturbances. It is therefore suggested that the scheme described in this paper is applicable to all acid-base disturbances.
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000097:blood / Q000175:diagnosis*; D000142:Acidosis, Respiratory / Q000097:blood; D000471:Alkalosis / Q000097:blood / Q000175:diagnosis*; D000472:Alkalosis, Respiratory / Q000097:blood; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D004285:Dogs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010313:Partial Pressure
chemical_list: D002245:Carbon Dioxide