Interaction of psychoactive drugs with the Mg+2 requiring ATPase associated with isolated synaptic vesicles.
A large series of CNS active drugs have been tested for their possible effect on the Mg+2 dependent ATPase associated with isolated synaptic vesicles. Antipsychotic agents and cocaine showed inhibition, of a non-competitive type. The implications of this finding for a synaptic theory of psychosis are discussed.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013572:Synaptic Vesicles / Q000201:enzymology*
D014150:Antipsychotic Agents; D011619:Psychotropic Drugs; D000251:Adenosine Triphosphatases; D008274:Magnesium; D003042:Cocaine