Correlated expression of a B-lymphocyte-specific glycoprotein (gp27/35) and the EBV receptor/C3 receptor complex in sublines from the same Burkitt lymphoma.
A series of virus-producer and non-producer sublines, derived from the Burkitt lymphoma line Jijoye and its P3HR-1 clone, were previously found to differ in the expression of EBV receptors and, in parallel, C3 receptors. The differences could be related to an "internal selection" caused by the cytopathic P3HR-1 virus variant, favouring the growth of receptor-negative cells. We have now analyzed the same lines for the expression of a B-lymphocyte-specific glycoprotein (gp27/35). A close parallellism was found between the expression of the EBV receptor-complement receptor complex and the glycoprotein, measured by quantitative absorption. The results favour a relationship between gp27/35 and EBV/C3 receptor expression.
D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002051:Burkitt Lymphoma / Q000276:immunology*; D002460:Cell Line; D003176:Complement C3 / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007106:Immune Sera
D000936:Antigen-Antibody Complex; D003176:Complement C3; D006023:Glycoproteins; D007106:Immune Sera