Protective effect of polymyxin B sulfate in experimental enterobacterial infection in mice.
The mouse model of intraperitoneal enterobacterial sepsis was used to evaluate the anti-endotoxic effect of polymyxin B sulfate. Single or multiple therapeutic doses of polymyxin, administered either before or after lethal challenge with Serratia marcescens, produced statistically and clinically significant protective effects.
D000818:Animals; D004195:Disease Models, Animal; D004731:Endotoxins / Q000097:blood; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D008033:Limulus Test; D051379:Mice; D009928:Organ Specificity; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011113:Polymyxins / Q000627:therapeutic use*
D004731:Endotoxins; D011113:Polymyxins; D011112:Polymyxin B