Brain neurotransmitter receptors in Friedreich's ataxia.
The binding of 3H-quinuclidinyl benzilate, a muscarinic cholinergic antagonist, of 3H-dihydroalprenolol, a beta adrenergic antagonist, and of 3H-flunitrazepam, a ligand which labels benzodiazepine receptors, was examined in several regions of control and Friedreich's ataxia (FA) brains. 3H-Quinuclidinyl benzilate binding appeared to increase in the inferior olivory nucleus, anterior and posterior cerebellar vermi but was unaltered in the dentate nucleus and cerebellar hemisphere of FA brain. The binding of 3H-dihydroalprenolol seemed to increase in the inferior olivary nucleus yet was not different from controls in the dentate nucleus, cerebellar hemisphere, anterior and posterior cerebellar vermi of FA brains. 3H-Flunitrazepam binding was slightly lowered in the inferior olivary and dentate nuclei but was unchanged in the other FA brain regions examined. The present study suggests possible trends in neurotransmitter receptor alterations in post-mortem brain tissue of FA patients.
D000328:Adult; D001569:Benzodiazepines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002529:Cerebellar Nuclei / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D005621:Friedreich Ataxia / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009847:Olivary Nucleus / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D011955:Receptors, Drug; D011976:Receptors, Muscarinic; D001569:Benzodiazepines; D004082:Dihydroalprenolol; D005445:Flunitrazepam; D011813:Quinuclidinyl Benzilate