Development of tolerance to the ACTH-releasing effects of beta-endorphin.
Acute intracisternal injection of human beta-endorphin results in increased plasma concentration of adrenocorticotropic hormone (ACTH). Repeated injections of beta-endorphin are associated with the development of tolerance with regard to this ACTH-stimulating effect.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D004361:Drug Tolerance; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats
D004723:Endorphins; D009270:Naloxone; D000324:Adrenocorticotropic Hormone