title: The effect of seven vasopressors of halothane MAC in dogs.
abstract: We evaluated the effects of ephedrine, mephentermine, metaraminol, phenylephrine, methoxamine, noradrenaline and adrenaline on halothane anaesthetic requirement (MAC) in dogs. MAC increased significantly only during ephedrine infusion (50%) although significance was approached with mephentermine (21%). Phenylephrine, metaraminol, methoxamine, noradrenaline and adrenaline did not change MAC. Arterial pressure was increased 50-100% with all agents. Our results support the hypothesis that anaesthetic requirement may be related, in part, to release of brain noradrenaline.
mesh_terms: D000769:Anesthesia, Inhalation; D000818:Animals; D001158:Arteries / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D004809:Ephedrine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006221:Halothane; D006863:Hydrogen-Ion Concentration; D008616:Mephentermine / Q000494:pharmacology; D008680:Metaraminol / Q000494:pharmacology; D008729:Methoxamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010656:Phenylephrine / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D002245:Carbon Dioxide; D010656:Phenylephrine; D008680:Metaraminol; D004809:Ephedrine; D008729:Methoxamine; D010100:Oxygen; D008616:Mephentermine; D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine