Effects of iproveratril on isolated heart mitochondria.
The effects of iproveratril on oxygen uptake and oxidative phosphorylation of succinate, glutamate and alfa-ketoglutarate were studied. Oxidative phosphorylation and oxidation of NAD+-linked substrated by heart mitochondria were depressed by 1.15 times 10-3M iproveratril. The activity of NADH-oxidase, NADH-cytochrome c reductase and heart mitochondrial transporting particles were depressed by iproveratril. When succinate was the substrate oxidative phosphorylation was depressed but oxygen uptake was stimulated about 370%. Swelling induced by iproveratril was analysed by electron microscopy.
D000818:Animals; D003579:Cytochrome Reductases / Q000037:antagonists & inhibitors; D003574:Cytochrome c Group; D005971:Glutamates / Q000378:metabolism; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000648:ultrastructure*; D009243:NAD; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011048:Polarography; D051381:Rats; D013386:Succinates / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology*
D003574:Cytochrome c Group; D005971:Glutamates; D007656:Ketoglutaric Acids; D013386:Succinates; D009243:NAD; D014700:Verapamil; D009247:NADH, NADPH Oxidoreductases; D003579:Cytochrome Reductases