Persistence of avian oncoviruses in chicken macrophages.
Inoculation of avian oncoviruses into 1- to 2-month old chickens led to a rapid production of antiviral humoral antibodies. Under these conditions it was found that avian leukosis viruses are sequestered in macrophages of peripheral blood, in which they can persist for a long period of time (up to about 3 years). In contrast, avian sarcoma viruses were never found in macrophages from chickens during the progression of sarcomas or after regression of the tumors.
D001355:Alpharetrovirus / Q000254:growth & development* / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001353:Avian Leukosis / Q000382:microbiology*; D001358:Avian Sarcoma Viruses / Q000254:growth & development; D002060:Bursa of Fabricius / Q000382:microbiology; D002645:Chickens; D008264:Macrophages / Q000382:microbiology*; D001357:Sarcoma, Avian / Q000382:microbiology*; D013154:Spleen / Q000382:microbiology
D000914:Antibodies, Viral