Accumulation and removal of Hg203 in different regions of the rat brain.
We have studied the brain regional distribution of methyl mercury following intravenous administration of CH3 203HgCl in rat. Early peak levels were obtained in cerebellum, medulla oblongata and midbrain. The efficacy of removal of 203Hg by different chelators is also region dependent. The most efficient chelator for brain mercury proved to be mesodimercaptosuccinic acid.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002614:Chelating Agents / Q000627:therapeutic use*; D008297:Male; D008630:Mercury Poisoning / Q000188:drug therapy / Q000378:metabolism*; D008767:Methylmercury Compounds / Q000378:metabolism*; D010396:Penicillamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D004113:Succimer / Q000627:therapeutic use; D014018:Tissue Distribution
D002614:Chelating Agents; D008767:Methylmercury Compounds; D004113:Succimer; D010396:Penicillamine