The role of p-hydroxylation of amphetamine in its peripheral mode of action.
Desipramine completely abolished the blood pressure response to (+) amphetamine in the rat, whereas the tricyclic antidepressant iprindole did not reduce this response. Since both tricyclic drugs inhibit the aromatic hydroxylation of amphetamine, these studies do not support the hypothesis that hydroxylated metabolites of amphetamine, p-hydroxyamphetamine and p-hydroxynorephedrine are essential for the peripheral sympathomimetic effects of amphetamine.
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D003891:Desipramine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006801:Humans; D006900:Hydroxylation; D007488:Iprindole / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D007488:Iprindole; D000661:Amphetamine; D003891:Desipramine; D003913:Dextroamphetamine; D009638:Norepinephrine