Beta2-adrenergic stimulation of thyroid hormone secretion.
The influence on thyroid hormone secretion of the nonselective beta-adrenergic stimulant isoproterenol (IPNE), of a selective beta1-adrenergic stimulant, 1-isopropylamino-3-(2-thiazoloxy)-2-propanol (ITP), and of a selective beta2-adrenergic stimulant, terbutaline, was investigated in mice. A combination of light microscopy (colloid droplet formation) and bioassay (blood radioiodine--BRI--measurements) was used. IPNE and terbutaline induced formation of colloid droplets and increased BRI levels, whereas ITP was ineffective. The responses to IPNE and terbutaline were abolished or reduced by pretreatment with L-propranolol, but were not inhibited for pretreatment with D-propranolol or phentolamine. The results indicate that secretion of thyroid hormone can be induced through the mediation of beta2-adrenergic receptors.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D003102:Colloids; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013237:Stereoisomerism; D013726:Terbutaline / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D013963:Thyroid Hormones / Q000378:metabolism*; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D003102:Colloids; D013963:Thyroid Hormones; D011433:Propranolol; D007545:Isoproterenol; D013726:Terbutaline; D010646:Phentolamine