Physical separation of "suppressor" from "helper" thymocytes.
Thymocytes from 1-month-old NZB/W mice were separated at unit gravity and then studied for helper or suppressor effects in a GVH assay. Thymocytes with a settling rate of 4 to 6 mm/hr suppressed but did not help. In contrast, help but no suppression characterized thymocytes settling at 6 to 10 mm/hr. Thus helper and suppressor thymocytes in this GVH assay were physically separated.
D000818:Animals; D002469:Cell Separation; D005260:Female; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy; D051379:Mice; D008814:Mice, Inbred NZB; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology