Spontaneous rupture of a liver cell adenoma after long term methyltestosterone: report of a case successfully treated by emergency right hepatic lobectomy.
A case of spontaneous rupture of a liver cell adenoma is reported in a female transexual treated with methyltestosterone 150 mg daily for 7 years. Emergency right hepatic lobectomy was performed successfully. Histology showed peliosis hepatis also. Emergency resection of a liver cell adenoma has been reported in a young woman taking oral contraceptives, and an elective resection in another female transexual treated with methyltestosterone. However, to the best of our knowledge this is the first case of emergency resection of a spontaneously ruptured liver cell adenoma in a transexual treated with long term methyltestosterone. Since there are numerous other patients similarly treated, it may be expected that this complication will be seen again.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000601:surgery; D056486:Chemical and Drug Induced Liver Injury; D004630:Emergencies; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000601:surgery; D008777:Methyltestosterone / Q000009:adverse effects*; D012422:Rupture, Spontaneous / Q000601:surgery; D013997:Time Factors; D014189:Transsexualism
D008777:Methyltestosterone