[Characteristics of the response of mice with temporary immunodepression to the administration of live or inactivated vaccine against tick-borne encephalitis].
Mice with immunity defects caused by administration of cyclophosphane were inoculated with an inactivated vaccine or Langat virus (TP-21 strain) considered to be an approximate model of the vaccine against tick-borne encephalitis. In mice with depressed immune response, the asymptomatic infection caused by Langat virus turns into acute form and encephalitis with a fatal outcome develops in 86--100%. Pre-treatment with inactivated tick-borne encephalitis vaccine did not protect the animals with the immunity defect against neuroinfection induced by subsequent inoculation with Langat or tick-borne encephalitis virus. The experimental results suggest that the use of a live vaccine against tick-borne encephalitis in specimens with immunity defects is very dangerous because of the possibility of affection of the central nervous system.
D000818:Animals; D003520:Cyclophosphamide / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D012672:Semliki forest virus / Q000276:immunology; D012845:Sindbis Virus / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage*; D014765:Viral Vaccines / Q000008:administration & dosage*
D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D003520:Cyclophosphamide
Osobennosti otveta mysheĭ s vremennoĭ immunodepressieĭ na vvedenie zhivoĭ ili inaktivirovannoĭ vaktsiny protiv kleshchevogo éntsefalita.