Juvenile nasopharyngeal angiofibroma.
A case of juvenile nasopharyngeal angiofibroma in a 14 year old boy is presented on account of the endocrinological investigation performed before, during, and after treatment with 15 mg/day diethylstilbestrol for more than one month. Previously, the tumor had recurred in spite of extensive surgery. Secondary sexual characteristics were normal and the development of puberty at the age of 12-13 years seemed not to have influenced tumor growth. In contrast to certain previous reports, normal functions were found regarding the pituitary, the gonads, the adrenal cortex, and the thyroid gland in our patient. The tumor continued to grow in spite of the diethylstilbestrol therapy.
D015065:17-Hydroxycorticosteroids / Q000378:metabolism*; D000293:Adolescent; D004054:Diethylstilbestrol / Q000627:therapeutic use; D013006:Growth Hormone / Q000378:metabolism*; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D015065:17-Hydroxycorticosteroids; D013973:Thyrotropin-Releasing Hormone; D004054:Diethylstilbestrol; D013972:Thyrotropin; D013006:Growth Hormone