title: Attenuated dynamic responses of primary endings of muscle spindles: a basis for depressed tendon responses in acrylamide neuropathy.
abstract: Depressed or lost tendon reflexes commonly observed in patients with peripheral neuropathies may result partly from attenuation of the dynamic discharge from the primary endings of muscle spindles. This possibility was investigated in cats with an experimental neuropathy induced with acrylamide (30 mg/kg/day intramuscularly). Achilles tendon reflexes and the dynamic discharge from primary muscle spindles were evaluated after five or ten injections of acrylamide. After five injections the animals were moderately impaired neurologically, the Achilles tendon reflex was difficult to elicit in 2 of 5 animals, and the dynamic responses of primary endings of soleus muscle spindles to stretch were depressed. Following ten injections of acrylamide the cats were severely impaired neurologically; tendon responses were either absent or difficult to elicit, and the dynamic responses of their muscle spindles to stretch were reduced by 50% (p less than 0.01). Additionally, the spindels responded to stretch with only 20 to 30% the normal number of afferent impulses. These data suggest that lost tendon responses in acrylamide neuropathy result in part from inadequate activation of motoneurons by spindle afferent discharge.
mesh_terms: D000178:Acrylamides; D000818:Animals; D002415:Cats; D005260:Female; D008297:Male; D009470:Muscle Spindles / Q000503:physiopathology*; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D012021:Reflex, Abnormal / Q000503:physiopathology*; D012023:Reflex, Monosynaptic; D012026:Reflex, Stretch
chemical_list: D000178:Acrylamides