[Differences in the structure of adrenalin and ACTH receptors in adipose cells of rats].
The treatment of adipose tissue of the rat epidiymis with trypsin decreased the lipolytic action of ACTH by 95%, and the lipolytic action of adrenalin by 50%. Supplementation of the incubation sample with lysolecithin suspension led to a complete loss of the tissue sensitivity to ACTH and a 40% decrease in the sensitivity to adrenalin. A conclusion is made about a different structure of adrenalin and ACTH-receptors in the plasma membrane of adipose cells.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008053:Lipid Mobilization / Q000187:drug effects; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013329:Structure-Activity Relationship
D011956:Receptors, Cell Surface; D000324:Adrenocorticotropic Hormone; D004837:Epinephrine
Razlichnaia struktura adreno- i aktgretseptorov v zhirovy kletkakh krysy.