In vivo inhibition of the tyrosinase of hamster melanoma with sodium diethyldithiocarbamate.
In vivo inhibition of the DOPA-oxydase activity of the soluble tyrosinase fraction of melanotic hamster melanoma is found after i.p. administration of diethyldithiocarbamate, with considerable increase in the content of SH-groups which probably play the role of free radical scavengers.
D000818:Animals; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D003300:Copper / Q000032:analysis; D004050:Ditiocarb / Q000494:pharmacology*; D008297:Male; D008545:Melanoma / Q000032:analysis / Q000201:enzymology*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D009374:Neoplasms, Experimental / Q000032:analysis / Q000201:enzymology; D013438:Sulfhydryl Compounds / Q000032:analysis; D013859:Thiocarbamates / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D013859:Thiocarbamates; D003300:Copper; D004050:Ditiocarb; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase