title: Effect of gold on the immune response of mice.
abstract: Separate concurrent injection of organic gold compounds and antigen into mice resulted in immunoenhancement that could be measured by direct and indirect plaque-forming cells, rosette-forming cells, and serum antibody assays. Kinetics of the immune response showed variable effects through day 9 of the experiment. Studies with British anti-lewisite, a gold antagonist, showed that the gold must stay in the system 1 day to obtain immunoenhancement.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens; D006051:Aurothioglucose / Q000008:administration & dosage; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006046:Gold / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006386:Hemagglutination Tests; D006460:Hemolysin Proteins / Q000032:analysis; D006461:Hemolysis; D006462:Hemolytic Plaque Technique; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular / Q000187:drug effects*; D007273:Injections, Intramuscular; D051379:Mice; D008815:Mice, Inbred Strains; D011135:Polysaccharides, Bacterial; D012756:Sheep / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology; D013870:Thiomalates / Q000008:administration & dosage
chemical_list: D000941:Antigens; D006460:Hemolysin Proteins; D011135:Polysaccharides, Bacterial; D013870:Thiomalates; D006051:Aurothioglucose; D006046:Gold; D003165:Complement System Proteins