Immune-complex involvement in the pathogenesis of infectious bursal disease virus in chickens.
Frozen kidney sections from chickens inoculated with infectious bursal disease virus (IBDV) were stained with fluorescein-conjugated rabbit anti-chicken gamma-globulin. Fluorescence was observed in the renal glomeruli of infected chickens, indicating that gamma-globulins, probably in the form of immune complexes, had lodged in the glomeruli of IBDV-infected chickens. This suggests that immune complexes may play an important role in the pathogenesis of IBDV infections in chickens.
D000818:Animals; D000936:Antigen-Antibody Complex; D002060:Bursa of Fabricius / Q000276:immunology* / Q000382:microbiology; D002645:Chickens; D005455:Fluorescent Antibody Technique; D007243:Infectious bursal disease virus / Q000276:immunology*; D007668:Kidney / Q000276:immunology / Q000473:pathology; D011201:Poultry Diseases / Q000276:immunology*; D012087:Reoviridae / Q000276:immunology*
D000936:Antigen-Antibody Complex