title: The use of lorazepam as a soporific and for premedication.
abstract: An open study, in which 48 patients scheduled for elective surgery received either 1,25 mg or 2,5 mg of lorazepam (orally) as a soporific the night before surgery and as premedication immediately prior to surgery, revealed that lorazepam produced a good night's rest and a desirable calm immediately prior to surgery. Vital signs remained stable throughout the operative procedure, and vomiting and other reactions were virtually absent.
mesh_terms: D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D011182:Postoperative Care; D011229:Preanesthetic Medication; D012890:Sleep / Q000187:drug effects*; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D008140:Lorazepam