Relationship between Epstein-Barr virus genome number, amount of nuclear antigen, and early antigen inducibility in diploid and tetraploid lymphoma cells of related origin.
In a collection of near-diploid and near-tetraploid Raji sublines and somatic Raji/Raji hybrids a linear relationship was found between the number of Epstein-Barr virus (EBV) genome copies and the relative amount of EBV-determined nuclear antigen per cell. Inducibility of the viral cycle by iododeoxyuridine and by P3HR-1 virus superinfection coulb be related to the number of resident EBV genome copies per haploid target cell. The implications of these findings are discussed.
D000956:Antigens, Viral / Q000032:analysis*; D002051:Burkitt Lymphoma / Q000276:immunology; D002460:Cell Line; D002467:Cell Nucleus / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis*; D004171:Diploidy; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000032:analysis* / Q000254:growth & development / Q000276:immunology; D006801:Humans; D006822:Hybrid Cells; D007065:Idoxuridine / Q000494:pharmacology; D011123:Polyploidy; D014775:Virus Activation / Q000187:drug effects
D000956:Antigens, Viral; D004279:DNA, Viral; D007065:Idoxuridine