title: The water proton spin-lattice relaxation times in virus-infected cells.
abstract: The water proton spin-lattice relaxation times in HEp-2 cell cultures were determined immediately after 1 h of polio-virus adsorption. The shortening of the water T1 was closely related to the multiplicity of infection, allowing direct inspections of the virus--cell interaction since the first steps of the infectious cycle. Virus-induced structural and conformational changes of cell constituents were suggested to be detectable by NMR investigation of cell water.
mesh_terms: D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D002472:Cell Transformation, Viral; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007822:Laryngeal Neoplasms; D014867:Water
chemical_list: D014867:Water