[Lysosomes-like thrombocyte alpha-granules: the activation and inhibition of the release of the contents in blood coagulation].
The mechanism of the release of alpha-granules constituents of thrombocytes was studied in the course of blood coagulation utilizing the fluorometric technique. The release reaction can be induced by proteolytic enzymes. The process is stimulated by the presence of extracellular Ca2+. This pattern of release reaction belongs to "release II" type. Aminazin can also induced release of alpha-granules constituents. Heparin inhibited release II induced by Ca2+ in citrated plasma, whereas streptase had no effect.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002479:Inclusion Bodies / Q000187:drug effects / Q000502:physiology*; D008247:Lysosomes / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits
Lizosomopodobnye al'fa-granuly trombotsitov: aktivatsiia i ingibirovanie osvobozhdeniia soderzhimogo pri gemokoaguliatsii.