title: The effects of two analogs of dopamine on ganglionic transmission in the sympathetic nervous system.
abstract: Two aminotetralin analogs of dopamine were studied for their effects on ganglionic transmission in the sympathetic nervous system. Nerve activity (spontaneous firing or evoked action potentials) was recorded on a preganglionic nerve (splanchnic), a mixed nerve (lumbar chain) and several postganglionic nerves (external carotid branch and renal nerve). 6,7-Dihydroxy-2-dimethylaminotetralin and 5,6-dihydroxy-2-dimethylaminotetralin were observed to markedly inhibit spontaneous firing in the renal nerve, external carotid branch and lumbar chain. Splanchnic nerve activity was unaltered, 6,7-Dihydroxy-2-dimethylaminotetralin also depressed evoked responses to submaximal stimulation in the external carotid branch and lumbar chain. These results suggest a ganglionic site of action. Since functional vasomotor activity in the isolated perfused canine forelimb in response to preganglionic nerve stimulation was unaltered, it was concluded that 6,7-dihydroxy-2-dimethylaminotetralin may depress transmission only at certain ganglionic pathways.
mesh_terms: D000818:Animals; D002415:Cats; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000294:innervation; D008297:Male; D013153:Splanchnic Nerves / Q000187:drug effects; D013233:Stellate Ganglion / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D004298:Dopamine