Effect of 60amino-6-deoxy-D-glucose hydrochloride on influenza infection in mice.
A prophylactic effect of 6-amino-6-deoxy-D-glucose hydrochloride (AG) in influenza-infected mice was demonstrated. A dose of 500 mg AG per kg body-weight given intranasally 2000 mouse intranasal LD50) protected 32-40 per cent of the animals from death. The virus titres in the lungs and serum were lower in treated mice than in untreated ones. After AG administration, low interferon titres were demonstrated in the lungs and serum. The group of infected mice, untreated with AG, was examined electron microscopically. Virus was demonstrated on the surface of granular pneumocytes and in the lumen of lung alveoli.
D000281:Administration, Intranasal; D000606:Amino Sugars / Q000627:therapeutic use*; D000818:Animals; D001681:Biological Assay; D001769:Blood / Q000382:microbiology; D003847:Deoxyglucose; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007369:Interferon Inducers; D007372:Interferons / Q000032:analysis / Q000097:blood; D008168:Lung / Q000032:analysis / Q000382:microbiology / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
D000606:Amino Sugars; D007369:Interferon Inducers; D007372:Interferons; D003847:Deoxyglucose