The treatment of ACTH Paraneoplastic syndrome with aminoglutethimide.
A 60-year-old white female with oat-cell carcinoma of the lung presents with a recurrent pulmonary nodule and Cushing syndrome. The tumor is uncontrollable with MeCCNU and cyclophosphamide (Cytoxan), consequently the symptoms of Cushing disease become severe. Cushing syndrome is documented by laboratory examinations. Aminoglutethimide, an anticonvulsant, is used to reverse the symptomatology and also the laboratory values. When aminoglutethimide is discontinued, the laboratory findings return to pretreatment levels.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000616:Aminoglutethimide / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000150:complications; D003480:Cushing Syndrome / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged
D000616:Aminoglutethimide; D000324:Adrenocorticotropic Hormone