title: [Pathobiochemistry of organ fibroses. Changes in the connective tissue metabolism in liver fibrosis and in chronic polyarthritis].
abstract: Many chronic inflammations of various origin are characterized by an elevated metabolic activity of connective tissue, causing an increased tissue proliferation. The authors first review the more recent methods of analyzing the connective tissue metabolism. Details of changes of this metabolism are described with reference to liver fibrosis and rheumatoid arthritis. First steps of a pathobiochemical diagnosis of activity in organ fibroses are discussed. It seems possible to judge the activity of liver fibrosis by estimating the serum activity of lysosomal glycosidases and serum levels of terminal collagen peptides. Elevated antiprotease serum levels in rheumatoid patients may indicate an inflammatory activity.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism*; D005959:Glucosidases / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D003012:Microbial Collagenase / Q000378:metabolism; D010447:Peptide Hydrolases; D010455:Peptides / Q000032:analysis; D011348:Procollagen N-Endopeptidase / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism; D013582:Synovial Fluid / Q000201:enzymology
chemical_list: D010455:Peptides; D011480:Protease Inhibitors; D005959:Glucosidases; D006026:Glycoside Hydrolases; D010447:Peptide Hydrolases; D011348:Procollagen N-Endopeptidase; D003012:Microbial Collagenase
vernacular_title: Zur Pathobiochemie von Organfibrosen. Veränderungen des Bindegewebsstoffwechsels bei Leberfibrose und bei chronischer Polyarthritis.