title: [Treatment of ischemic heart disease with beta-receptor blockers and isosorbide dinitrate (author's transl)].
abstract: The effects of a beta-receptor blocker (Betadrenol), an isosorbide dinitrate preparation (Isoket) and the combination of the two substances (Betaket) were compared with a placebo in a controlled double blind trial in 20 patients with confirmed attacks of angina pectoris and/or ischemic changes in the ECG on ergometer exercise. Important assessment criteria of the efficacy were regression of ischemic ECG changes on standardized ergometer exercise, increase in load resistance and the nitroglycerine requirement. Treatment with the combination of betablocker and isosorbide dinitrate (Betaket) was more effective in comparison to treatment with the individual substances.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy*; D004338:Drug Combinations; D004357:Drug Synergism; D005080:Exercise Test; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011674:Pulse / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D010919:Placebos; D007548:Isosorbide Dinitrate
vernacular_title: Die Behandlung der ischämischen Herzkrankheit mit Betarezeptorenblockern und Isosorbitdinitrat