Suppression of IgE antibody formation in mice: requirement for T-T lymphocyte interaction.
Norman SWR mice injected with syngeneic spleen cells from ovalbumin (Ov)-primed mice were unable to make IgE anti-Ov antibodies when challenged with alum-pertussis-Ov. Immune T lymphocytes were shown to be responsible for the inhibitory effects of adoptively transferred spleen cells. Treatment of recipient mice with mild x-irradiation or with cyclophosphamide 2 or 3 days before cell transfer resulted in abrogation of the suppressor effect of immune cells. The injection of T lymphocytes into x-irradiated milce restored the suppressive effect of immune cells. It thus appears that immune T cells provide the stimulus for activation of suppressor T cells of the host. Although the generation of suppression is antigen-specific, the expression of suppression appears to be nonspecific.
D000534:Alum Compounds / Q000276:immunology; D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology; D002450:Cell Communication; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014965:X-Rays
D000534:Alum Compounds; D007073:Immunoglobulin E; D010047:Ovalbumin; D006433:Hemocyanins