Arteriography and chemotherapy in localized trophoblastic disease, by means of local- (pelvic-) intraarterial infusion.
In spite of considerable progress in systemic chemotherapy in malignant throphoblastic disease, there remains a small group of patients who fail to respond to this type of therapy. Here the trophoblastic process may be localized by means of an arteriography, and treated by a local, intraarterial infusion of cytotoxic compounds in high concentration. The latter makes possible the treatment of processes localized in essential organs which are hard to remove, as well as in young women wishing to preserve their reproductive capacity. Our experiences is limited to one case of a young woman with chorioadenoma destruens in the uterus, resistant to systemic chemotherapy, yet successfully treated with pelvic, intraarterial infusion of cytotoxics.
D000328:Adult; D000792:Angiography; D003609:Dactinomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy
D003609:Dactinomycin