title: Leydig cell function in streptozotocin-induced diabetic rats.
abstract: Streptozotocin diabetic rats were infertile as a result of decreased Leydig cell function of the testes. The major changes found were: decreased number of Leydig cells and their spontaneous secretion of testosterone. No change in the receptors to LH on the Leydig cells was observed. LH was found to be obligatory for the regulation of Leydig cell function and fertility.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000378:metabolism / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology; D007985:Leydig Cells / Q000503:physiopathology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D013737:Testis / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D006063:Chorionic Gonadotropin; D007328:Insulin; D011956:Receptors, Cell Surface; D013739:Testosterone