title: [Information regulation in the vegetative periphery].
abstract: The importance of the proteoglycans (PG) of the extracellular matrix in regulating the information reaching the vegetative periphery is demonstrated. Information brought to the vegetative periphery by autonomic nerves and the microcirculatory system are coded by the PG, thereby changing their biochemical structure. These changes (i.e. degree of polymerisation, capacity of ion-exchange and water-binding, electrostatical tonus) stimulate via the specific cellglycocalyx the cAMP-adenylcyclase-system of the cells in the vegetative periphery. In this way the information becomes decoded and is followed by the enzymatically steered answer of the cell. The center for all of these relations is the fibrocyte. The fibrocytes form the metabolic active center in the vegetative periphery and answer to "informative" changes in the extracellular matrix with a situation-dependent synthesis of PG. The possibilities of modulating the intercellular transfer of informations --- various cell contacts, temporary intercytoplasmic connections (fusomes), the role of mastcells.
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology*; D006801:Humans; D010525:Peripheral Nerves / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: D011509:Proteoglycans
vernacular_title: Informationssteuerung in der vegetativen Peripherie.