Studies on osteoporosis. II. Effect of estrogens and fluoride on experimental osteoporosis. A preliminary report.
Total skeletal calcium level was determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heparin produced significant osteoporosis in C3H/St(Ha) mice of 3--5 months of age. Treatment with a conjugated natural estrogen preparation (Premarin) prevented this phenomenon but high level fluoride in the drinking water failed to show preventive activity.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D006493:Heparin / Q000494:pharmacology; D051379:Mice; D010024:Osteoporosis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*
D004966:Estrogens, Conjugated (USP); D006493:Heparin; D005459:Fluorides; D002118:Calcium