Multiple pituitary hormone deficiencies in eight siblings of one Jewish Moroccan family.
In a Jewish Moroccan inbred family, 8 of 12 siblings were found to have multiple deficiencies of pituitary hormones, including GH, TSH and gonadotrophins. The parents showed no deficiency and are in good health, as are the other 4 siblings. The investigations carried out indicate that in this family the etiology is hereditary in nature, probably being autosomal recessive, with the defect located in the pituitary gland.
D000293:Adolescent; D000328:Adult; D000365:Age Determination by Skeleton; D001827:Body Height; D002648:Child; D003241:Consanguinity; D005260:Female; D005808:Genes, Recessive; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000235:genetics* / Q000503:physiopathology; D007031:Hypothalamus / Q000503:physiopathology; D007585:Jews; D008297:Male; D009018:Morocco / Q000208:ethnology; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000172:deficiency*
D006065:Gonadotropins, Pituitary; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone