Epoxide metabolites of protriptyline in rat urine.
Two epoxide metabolites of 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (protriptyline) were identified in the urine of rats given 14-C-labeled drug. They were characterized by mass spectrometry, nuclear magnetic resonance spectrometry, and chemical reactivity as 10,11-dihydro-10,11-epoxy-5(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (I) and 10,11-dihydro-10,11-epoxy-5(3-aminopropyl)-5H-dibenzo[a,d]cycloheptene (II). Over twice as much I as II was excreted and together the two metabolites accounted for approximately 40% of the urinary radioactivity.
D000818:Animals; D002855:Chromatography, Thin Layer; D004852:Epoxy Compounds / Q000652:urine*; D004988:Ethers, Cyclic / Q000652:urine*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D004852:Epoxy Compounds; D004988:Ethers, Cyclic