Transport of acyclic polyols in Saccharomyces cerevisiae.
Acyclic polyols (erythritol, xylitol, ribitol, D-arabinitol, mannitol, sorbitol and galactitol) are not metabolized by Saccharomyces cerevisiae. They are taken up by a fast non-active process, reaching 40-70% distribution referred to total cell water. The uptake is insensitive to temperature, pH (between 4 and 8), 2,4-dinitrophenol and uranyl ions. Its initial rate rises linearly with concentration from 10(-5)M to 1M. The process resembles simple diffusion through large pores or the trapping of the whole solution on the surface. Protoplasts behave like whole cells in this respect. Only erythritol shows a second type of uptake which is inhibitor-insensitive but temperature-dependent.
D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D004140:Dinitrophenols / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011134:Polysaccharides / Q000378:metabolism; D011523:Protoplasts / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013402:Sugar Alcohols / Q000378:metabolism*; D013696:Temperature; D014501:Uranium / Q000494:pharmacology
D004140:Dinitrophenols; D011134:Polysaccharides; D013402:Sugar Alcohols; D014501:Uranium