Catecholamine and cyclic nucleotide response of sheep to the injection of Clostridium welchii type D epsilon toxin.
Injection of Clostridium welchii (C. perfringens) type D epsilon toxin into sheep caused large increases in catecholamine and cyclic adenosine 3',5'-monophosphate levels and moderate increases in cyclic guanosine 3',5'-monophosphate levels. Haemoconcentration also occurred. It is suggested that a rapidly developing brain oedema is the stimulus for a release of catecholamines which in turn activates adenyl cyclase. The resulting rise in cAMP causes glycogenolysis and hyperglycaemia.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D001786:Blood Glucose; D002395:Catecholamines / Q000097:blood*; D003013:Clostridium; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D012756:Sheep
D001427:Bacterial Toxins; D001786:Blood Glucose; D002395:Catecholamines; D000242:Cyclic AMP; D006152:Cyclic GMP; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine