[Examination of the acute effect of prednisolone on the acid secretion of the stimulated gastric mucosa in man].
In comparison with the maximal acid stimulation produced by intravenous infusion of histalog (2 mg/kg bw/h), a single intravenous injection of 25 mg prednisolone during maximal acid stimulation produced by pentagastrin (1.5 mug/kg bw/h) does not cause a significant change of secretion rate or ionic composition of gastric juice in man. This suggests that there is a greater dependence of histalog stimulation than of pentagastrin stimulation on the normal secretion of glucocorticoids.
D000328:Adult; D002712:Chlorides / Q000032:analysis; D004347:Drug Interactions; D005260:Female; D005750:Gastric Juice / Q000032:analysis / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin; D011188:Potassium / Q000032:analysis; D011239:Prednisolone / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D012964:Sodium / Q000032:analysis
D002712:Chlorides; D006632:Histamine; D012964:Sodium; D011239:Prednisolone; D010418:Pentagastrin; D011188:Potassium
Akute Wirkung von Prednisolon auf die Säuresekretion der stimulierten menschlichen Magenschleimhaut