Restoration of the gonadotrophin response to LH-RH and oestrogen administration in patients after molar abortion.
The relation of the hypothalamic-pituitary effect on gonadotrophin secretion and the concentration of serum hCG after molar abortion was investigated. Gonadotrophin release after a bolus injection of LH-RH or conjugated oestrogens was observed in 17 women until 5 months after molar abortion. Little if any response of gonadotrophin was observed at a hCG level of 100 mIU/ml or more, but the response of LH and FSH to LH-RH were restored to normal when the serum hCG level decreased to below 100 mIU/ml. A normal response of LH to conjugated oestrogens was observed at a serum hCG level of 20 mIU/ml or less. These findings suggest that a high level of hCG interferes with pituitary gonadotrophin secretion, that the threshold hCG levels for normal responses of gonadotrophins to LH-RH and oestrogen are 100 and 20 mIU/ml, respectively, and that secretion of gonadotrophins is restored even in the presence of a low hCG level.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D004966:Estrogens, Conjugated (USP); D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D011863:Radioimmunoassay; D014594:Uterine Neoplasms / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*
D006063:Chorionic Gonadotropin; D004966:Estrogens, Conjugated (USP); D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone