[Localization of the gene for phosphoglycolate phosphatase (PGP) on the chromosome 16 by interspecific hybridization (author's transl)].
Eight primary man-mouse (C11D/TK-) hybrids, twenty three primary and seven secondary man-hamster (CH/HGPRT-) were analyzed for human phosphoglycolate phosphatase (PGP) and for human chromosomes. The following results were obtained: 1. A positive correlation is observed between the chromosome 16 and PGP. 15 hybrids are chr.16+PGP+, 14 hybrids are chr.16-PGP- and 4 hybrids are chr.16-PGP+. 2. The percentage of dissociation between PGP and the chr.16 is low (12%) in comparison with the high percentage of dissociation between PGP and the other autosomes (between 37% and 65%). 3. Excepted the chromosome 16, the other autosomes are observed in hybrids PGP-. These different results indicate the localization of the gene for human PGP on the chromosome 16. The dissociation results chr.16-PGP+ are explained by the breakage of the chr.16 in the hybrids.
D000818:Animals; D002902:Chromosomes, Human, 16-18; D000013:Congenital Abnormalities; D006224:Cricetinae; D006016:Glycolates; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency; D051379:Mice; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*
D006016:Glycolates; D007041:Hypoxanthine Phosphoribosyltransferase; C022408:phosphoglycolate phosphatase; D010744:Phosphoric Monoester Hydrolases
Localisation du gène phosphoglycolate phosphatase (PGP sur le chromosome 16 par l'hybridation cellulaire interspecifique.