[Formation of nitrosyl complexes of nonheme iron (2.03 complexes) in animal tissues in vivo].
Formation or dinitrozyl non-haem iron complexes (2.03 complexes) in white rats' tissues in vivo has been studied. The formation of these complexes has been examined in the liver kidneys and small intestines when injecting p/o NaNO2 to the rats. Most of the complexes have been found in the liver. They have not been detected in the heart, spleen, muscle, cerebrum and marrow in vivo. 3-4-fold content of 2.03 complexes has been determined while introducing iron and NaNO2 in running water. This effect has not been found when introducing iron and NaNO2 simultaneously. The mechanism of 2.03 complex formation in the animal tissues in vivo has been proposed. According to this mechanism these complexes are formed in the tissues when Fe-NO from nitrozyl non-haem from complexes originating in blood passes into SH-group of protein in tissues. The formation of 2.03 complexes in vivo has been found in blood uniform elements.
D000284:Administration, Oral; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds / Q000378:metabolism*; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism*; D008099:Liver; D009573:Nitrites / Q000378:metabolism*; D009603:Nitroso Compounds / Q000096:biosynthesis*; D051381:Rats; D012977:Sodium Nitrite / Q000378:metabolism*; D014018:Tissue Distribution
D005296:Ferrous Compounds; D009573:Nitrites; D009603:Nitroso Compounds; D007501:Iron; D012977:Sodium Nitrite
Obrazovanie nitrozil'nykh kompleksov negemovogo zheleza (kompleksov 2.03) v tkaniakh zhivotnykh in vivo.