[Response to ACTH of human adrenocortical cells isolated from normal glands and from adrenocortical adenoma (author's transl)].
The low sensitivity of adrenocortical adenoma to ACTH, documented in vivo, and in vitro, results from decreased cAMP generation in response to ACTH while distal steps of biosynthesis of cortisol are even more active in these tumoral cells than in normal adrenocortical cells.
D000236:Adenoma / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects*; D000306:Adrenal Cortex Neoplasms / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000242:Cyclic AMP / Q000096:biosynthesis; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis
D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D006854:Hydrocortisone
Réponse des cellules corticosurrénales humaines normales et tumorales à la corticotropine (ACTH).