title: Inducibility of the hepatic drug-metabolizing capacity of mice infected with Schistosoma mansoni.
abstract: The activities of some hepatic microsomal drug metabolizing enzymes, which are markedly depressed in mice infected with Schistosoma mansoni, can be increased by treatment with phenobarbital or 3-methylcholanthrene. Administration of these compounds to infected mice increased the capacity of the liver to metabolize drugs up to the maximum level inducible in non-infected animals. However, the increased hepatic microsomal mass, reflected in glucose 6-phosphatase activities and cytochrome b5 levels, observed in schistosome-infected mice, was not increased further by the same treatment. The changes in the activities of several drug metabolizing enzymes in vitro were confirmed in vivo by determination of hexobarbital-induced sleeping time and zoxazolamine-induced paralysis duration.
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D003580:Cytochromes / Q000378:metabolism; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008109:Liver Diseases, Parasitic / Q000378:metabolism*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000378:metabolism*
chemical_list: D003580:Cytochromes; D004364:Pharmaceutical Preparations; D008748:Methylcholanthrene; D005952:Glucose-6-Phosphatase; D010634:Phenobarbital