Humoral hypercalcaemia in a patient with renal-cell carcinoma.
In a patient with hypercalcaemia secondary to a renal-cell carcinoma, a concentration gradient of bioactivity was detected between the tumour effluent vein and the peripheral venous blood that was capable of stimulating adenylate cyclase in bone cells. Immuno-reactive PTH was undetectable in the tumour effluent and in the peripheral blood. It is concluded that a non-parathyroid humoral factor whose action involved cyclic AMP stimulation was responsible for the hypercalcaemia.
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D000242:Cyclic AMP / Q000032:analysis; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000150:complications* / Q000378:metabolism; D007680:Kidney Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone; D000242:Cyclic AMP