The effects of drugs on psychiatric patients' performance on the Halstead-Reitan neuropsychological test battery.
The relationship between the type and amount of psychotropic drug ingestion was evaluated for 184 psychiatric patients using a complex battery of cognitive-sensory-motor tests (Halstead-Reitan). The total patients' group included 68 psychotic patients who were being treated with either phenothiazines or "another drug," and 80 neurotically depressed patients who were taking either no drugs, phenothiazines, minor tranquilizers, tricyclic antidepressants, or sedatives. Little, if any, effect was noted in terms of psychological test performance when individual drug types were combined and considered in terms of dosage. However, upon a more specific analysis of the data, several suggestive trends occurred, demonstrating that individual drugs have variable effects and that some age groupings are more sensitive to drug effects than other groupings. As these trends were a result of a secondary analysis, further investigation was recommended in order to delineate the variables involved. For the present, this investigation has demonstrated the important influence of age and drug type variables upon patient neuropsychological test performance.
D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D010640:Phenothiazines; D011581:Psychological Tests; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D014149:Tranquilizing Agents / Q000627:therapeutic use
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D008996:Monoamine Oxidase Inhibitors; D010640:Phenothiazines; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents