Carcinogenic effect of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a postulated proximate pancreatic carcinogen in Syrian hamsters.
N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine, and these neoplasms showed a great tendency for invasion and metastasis. Also, HPOP induced tumors of the forestomach, liver, gallbladder, kidneys, and vagina (as did BOP). However, HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips, and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced; D006224:Cricetinae; D004067:Digestive System Neoplasms / Q000139:chemically induced; D005260:Female; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D010179:Pancreas / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced; D014565:Urogenital Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines; C013624:N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine