[Antistress effects of diazepam and activation of the positive reinforcing system upon changes on corticosteroid excretion and lipid level after peripheral electric pain stimulation].
It was shown in experiments on rats that the reaction of self-stimulation (SS) decreased the enhanced level of 11-hydrohycorticosteroids (11-HCS) in the blood after electrical pain stimulation(EPS) of the feet. Diazepam (1 mg/kg) decreased the levels of 11-HCS and beta-lipoproteids and increased the level of phospholipids after self-stimulation and pain stimulation. Diazepam and preliminary electrical pain stimulation induced activation of self-stimulation. It is concluded that diazepam and the activation of the positive reinforcing system exert similar effects on 11-HCS excretion and lipid levels after pain stimulation.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004558:Electric Stimulation; D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010146:Pain / Q000503:physiopathology*; D010743:Phospholipids / Q000097:blood*; D051381:Rats; D012054:Reinforcement, Psychology / Q000187:drug effects*; D012653:Self Stimulation
D015062:11-Hydroxycorticosteroids; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D010743:Phospholipids; D003975:Diazepam
Izuchenie antistressovogo deĭstviia diazepama i aktivatsii sistemy pozitivnogo podkrepleniia po izmeneniiam funktsii kory madpochechnikov i lipidnogo obmena pri perifericheskom elektrobolevom vozdeĭstvii.