title: [Effect of host cells on the course of chronic rabies virus infection in cell cultures].
abstract: Different patterns of rabies virus infection were observed in BHK-21/13S and HEp-2 cell cultures at late stages of persistent infections. The infection of BHK-21/13S cells was characterized by periodical increases and declines in the portion of the antigen-containing cells (from 100% to less than 1%) and low infectivity titers which did not correspond to fluctuations in the antigen production and occasional resistance to challenge with vesicular stomatitis virus. In contrast, persistently infected HEp-2 cell culture exhibited a more constant course of antigen production which never reached extreme points; the infectivity titers generally correlated with the portion of the antigen-containing cells. Cultivation in the presence of antirabies serum did not "cure" either of the cultures.
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D002452:Cell Count; D002460:Cell Line; D007928:Lethal Dose 50; D011818:Rabies; D011820:Rabies virus / Q000472:pathogenicity; D014721:Vesicular stomatitis Indiana virus; D014762:Viral Interference; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral
vernacular_title: Vliianie kletki-khoziaina na techenie khronicheskoĭ infektsii virusom beshenstva v kletochnykh kul'turakh.