Effect of cyclic nucleotides on the response of cells to infection by various herpesviruses.
The effect of varying the intracellular cyclic nucleotide concentration of mouse cells infected with HSV-1 or of duck embryo fibroblasts infected with Marek's disease virus has been studied. It has been shown in each case that agents that elevate the intracellular cAMP levels increase the yield of infectious virus or viral DNA, but inhibit cell division. cGMP enhances synthesis of viral DNA but allows continued synthesis of cell DNA.
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000494:pharmacology* / Q000502:physiology; D006152:Cyclic GMP / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D004279:DNA, Viral / Q000096:biosynthesis; D006564:Herpesviridae / Q000187:drug effects*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D011459:Prostaglandins E, Synthetic; D004247:DNA; D000242:Cyclic AMP; D006152:Cyclic GMP