title: In vitro and in vivo evaluation of change of local pH on bacteria in C.S.O.M.
abstract: An in vitro study has shown a high bactericidal activity of 2 per cent acetic acid. An in vitro study in 400 cases of C.S.O.M. has shown that conservative treatment of C.S.O.M. by pH change with 2 per cent acetic acid is better than antibiotic ear drops alone. However, combined therapy (pH change plus antibiotic ear drops) is definitely superior to single treatment by either of the two methods. Two per cent acetic acid is well tolerated by the middle ear mucosa except in 1 per cent cases, where its use had to be discontinued because of irritation. The use of 2 per cent acetic acid is highly recommended, particularly for poor nations, because of its negligible cost as compared to antibiotic ear drops.
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002470:Cell Survival; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D010033:Otitis Media / Q000188:drug therapy*; D011514:Proteus vulgaris / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents