Gastric secretion during anaesthesia and its inhibition by metiamide and other drugs.
The histamine H2-receptor antagonist, metiamide, inhibits the acid gastric secretion produced by chloralose-urethane anaesthesia in dogs carrying gastric cannulae chronically. This secretion is also prevented by atropine and hexamethonium. "Spontaneous" gastric secretion of vagal origin in conscious dogs is also blocked by metiamide.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002698:Chloralose / Q000037:antagonists & inhibitors*; D004285:Dogs; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006634:Histamine H1 Antagonists; D008785:Metiamide / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives*; D014520:Urethane / Q000037:antagonists & inhibitors*; D014630:Vagus Nerve / Q000502:physiology
D006584:Hexamethonium Compounds; D006634:Histamine H1 Antagonists; D002698:Chloralose; D014520:Urethane; D008785:Metiamide; D001285:Atropine; D013890:Thiourea