Development and experimental evaluation of a contrast medium for computed tomographic examination of the liver and spleen.
A lipoid based contrast material containing 53% of ethiodized oil in emulsion form was developed for computed tomography (CT) of the liver and spleen and tested in rabbits and monkeys. An intravenous dose of 0.2 ml/kg selectively opacified the liver and spleen, resulting in an average increase of 23 EMI units (500 scales) in the attenuation of the liver and a higher increase in the attenuation of the spleen. When injected into rhesus monkeys with carcinogen induced hepatomas there was a significant improvement in the visualization of the tumor, and small lesions, undetectable on the preliminary CT scan, became visible. Toxicity studies are in progress.
D000818:Animals; D003287:Contrast Media; D004655:Emulsions; D004998:Ethiodized Oil; D005260:Female; D000882:Haplorhini; D008099:Liver / Q000000981:diagnostic imaging*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging; D008253:Macaca mulatta; D008297:Male; D011136:Polysorbates; D011817:Rabbits; D013154:Spleen / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D004655:Emulsions; D011136:Polysorbates; D004998:Ethiodized Oil