Pulmonary cytomegalovirus infection: detection by Gallium 67 imaging in the transplant patient.
Cytomegalovirus (CMV) infeciton is a frequent complication during the first few months following renal transplantation. The diagnosis is sometimes difficult but may be made by viral culture, a fourfold rise in the CMV antibody titer, or by demonstration of the CMV inclusions in the affected tissue. An increased pulmonary uptake of galliulm citrate Ga 67 has been demonstrated following renal transplantation in two patients, each of whom had a fourfold rise in CMV complement fixing antibody titer, one of whom additionally had CMV inclusion bodies in a lung biopsy specimen prior to clinical or radiological demonstration of the pulmonary involvement. Gallium imaging, therefore, appears to be a valuable noninvasive test for early diagnosis of CMV pulmonary infections.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D005710:Gallium Radioisotopes; D006801:Humans; D016030:Kidney Transplantation; D008171:Lung Diseases / Q000276:immunology; D008297:Male; D011024:Pneumonia, Viral / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D014184:Transplantation, Homologous / Q000009:adverse effects
D000914:Antibodies, Viral; D005710:Gallium Radioisotopes