Quantitative aspects of a unified model of diffusion mediated receptor--cyclase coupling.
A quantitative model is presented of diffusion mediated coupling of adenylate cyclase to multivalent plasma membrane receptors which accounts for a wide range of phenomena including non linear occupation-activation plots with either positive or negative second derivatives, spare receptors, silent receptors, and negative and positive binding cooperativity. A non linear least square fit of the predicted equation for cyclase activation to available data predicts translational diffusion coefficients in the range of (10(-10) - 10(-11))cm2/s.
D000262:Adenylyl Cyclases; D000818:Animals; D004058:Diffusion; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008565:Membrane Proteins; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D013552:Swine / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D014667:Vasopressins; D000262:Adenylyl Cyclases