Intestinal pH as a factor in selection of animal models for bioavailability testing.
Previous in situ studies showed that intestinal drug absorption is strongly influenced by intestinal pH. Three animal species considered for bioavailability testing were studied in situ to determine intestinal pH. Results from the rat and dog correlated well with results in humans, while results from the rabbit did not. The rabbit appears to be a poor candidate for attempted animal-human bioavailability correlations.
D000818:Animals; D001646:Bile / Q000502:physiology; D001682:Biological Availability; D001702:Biopharmaceutics; D004285:Dogs; D004386:Duodenum / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000502:physiology*; D007583:Jejunum / Q000032:analysis; D008954:Models, Biological; D011817:Rabbits; D051381:Rats