Type C virus and immunoglobulin A production by murine myeloma MOPC-315: two independent activities.
The suspected correlation between cessation of type C virus production and halt in immunoglobulin secretion by murine myeloma cells was studied. Employing two variants of the murine myeloma MOPC-315, immunoglobulin A-producing and nonproducing cells, we demonstrated that the two myelomas release similar levels of type C viruses which share common nucleotide sequences and that the viral genomes are equally expressed within the cells. Thus, the suggested relation between these two activities does not apply for MOPC-315 cells and probably for other murine myelomas also.
D000818:Animals; D002460:Cell Line; D007070:Immunoglobulin A / Q000096:biosynthesis*; D051379:Mice; D009194:Myeloma Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology / Q000382:microbiology*; D012367:RNA, Viral / Q000235:genetics; D012190:Retroviridae / Q000235:genetics / Q000254:growth & development*; D014301:Trinitrobenzenes / Q000276:immunology; D014779:Virus Replication
D007070:Immunoglobulin A; D009194:Myeloma Proteins; D012367:RNA, Viral; D014301:Trinitrobenzenes