[Ratio of cyclo-3':5'-adenosinemonophosphate to cyclo-3':5'-guanosine-monophosphate in human tumor tissue].
In human tumor tissues of different degrees of differentiation--nevus-cell-nevus, basalioma, malign melanoma--the cAMP and cGMP content was determined and compared with the corresponding normal values. It is demonstrated that the quotient of the cAMP to the cGMP values is of importance rather than the latter values for themselves. For the benign tumor, this quotient differs only slightly from that of the adjacent normal, sound tissue. On the other hand, for the two malign tumors a drastic decrease of the quotient as compared to that of the normal tissue was found to occur.
D002280:Basal Cell Carcinoma / Q000032:analysis; D000242:Cyclic AMP / Q000032:analysis*; D006152:Cyclic GMP / Q000032:analysis*; D006801:Humans; D008545:Melanoma / Q000032:analysis; D009369:Neoplasms / Q000032:analysis*; D009506:Nevus / Q000032:analysis; D012016:Reference Values
D000242:Cyclic AMP; D006152:Cyclic GMP
Verhältnis von cyclo-3':5'-adenosinmonophosphat zu cyclo-3':5'-guanosinmonophosphat in menschlichen Tumorgeweben.