A transient rise in cyclic AMP levels following chemotactic stimulation of neutrophil granulocytes.
A short transient rise of cyclic AMP is observed within 1 minute after primary stimulation of neutrophils with chemotactic serum peptides containing classical anaphylatoxin (CAT). A second administration of these peptides after two minutes failed to produce a second peak of cAMP. Human serum albumin (HSA) which has chemokinetic but no chemotactic activities did not change cAMP levels. There was no significant change in cGMP levels within 1 minute following stimulation of rabbit neutrophils with chemotactic peptides or HSA.
D000706:Anaphylatoxins / Q000494:pharmacology*; D000818:Animals; D002630:Chemotactic Factors; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood; D006801:Humans; D007700:Kinetics; D009504:Neutrophils / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D012709:Serum Albumin / Q000494:pharmacology
D000706:Anaphylatoxins; D002630:Chemotactic Factors; D010455:Peptides; D012709:Serum Albumin; D000242:Cyclic AMP; D006152:Cyclic GMP