[Possible role of neuropeptides in regulating nucleic acid biosynthesis in the brain].
It has been studied the role of intracysternal administration of neuropeptides--five analogous of 8-lysinvasopressin (LVP) [Des-9-Gly-cine-amide-LVP (DGLVP), Tri-Gly-LVP, deamino-LVP (1--beta-mercaptopropionic acid-LVP), Leu4-LVP, Asn1,6-LVP] and two cardiotrop hexapeptides (acetylated and non) separated from the hypothalamus in the regulation of various types of RNA (GC and AU types n-RNA, r-RNA, t-RNA) biosynthesis in the brain. Using the combined method of phenol extraction, differential ultracentrifugation, gel-filtration and ultraviolet spectroscory of various types of RNA has been shown the increase in the content of r-RNA and t-RNA under the influence of DGLVP, Leu4-LVP and cardiotrop hexapeptide. Deamino-LVP, Tri-Gly-LVP and acetylated hexapeptide stimulate the rise in the content of r-RNA and AU type n-RNA (precursor of m-RNA). Ans1,6-LVP shows a nonspecific influence on the biosynthesis of the brain RNA. It has been suggested a hypothesis about a participation of the neuropeptides in the regulation of various types of the brain RNA biosynthesis, as a primary messanger (starting signals) during the stimulation of the initiation of cycloadenylate- and cycloguanylate-sensitive transcription, via phosphorylation of diverse RNA-polymerases. It was given a scheme of interaction between the messanger conception of neuropeptides and cyclic-3', 5'-monophosphate nucleotide-dependent transcription by which the cycloadenylate-dependent transcription appears to play a great role in the r-RNA and t-RNA biosynthesis and the cycloguanylate-dependent transcription -- in the biosynthesis of m-RNA.
D000546:Amanitins / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002467:Cell Nucleus / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000378:metabolism; D008236:Lypressin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D012335:RNA, Ribosomal / Q000032:analysis; D012343:RNA, Transfer / Q000032:analysis; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects
D000546:Amanitins; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D008236:Lypressin; D012313:RNA; D012343:RNA, Transfer; D000242:Cyclic AMP; D011494:Protein Kinases; D012321:DNA-Directed RNA Polymerases; D006152:Cyclic GMP
Vozmozhnaia rol' neĭropeptidov v reguliatsii biosinteza njkleinovykh kislot golovnogo mozga.