Induction of neurogenic tumors by nitrosotrialkylureas in rats.
Four nitrosotrialkylureas were each fed to groups of 15 male and 15 female Sprague-Dawley rats for 50 weeks in drinking water at the same molar concentration. Tumors of nervous origin arose after treatment with nitrosotrimethylurea (3/30), notrosotriethylurea (7/30), nitrosomethyldiethylurea (23/30), and nitrosoethyldimethylurea (8/30). A comparison of the relative stabilities of the four nitrosoureas in aqueous solution at various pH's showed no correlation with the tumorigenicities of the compounds.
D000818:Animals; D004355:Drug Stability; D005038:Ethylnitrosourea; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental; D009380:Neoplasms, Nerve Tissue / Q000139:chemically induced*; D009607:Nitrosourea Compounds; D051381:Rats; D012996:Solutions; D014867:Water
D009607:Nitrosourea Compounds; D012996:Solutions; D014867:Water; D008770:Methylnitrosourea; D005038:Ethylnitrosourea