title: Status of endogenous avian RNA tumor virus in Marek's disease lymphoblastoid cell lines and susceptibility of those lines to exogenous RNA tumor viruses.
abstract: Three lymphoblastoid cell lines from Marek's disease (MD) tumors, two MD virus (MDV) producer lines (MSB-1 and HPRS-1), and a nonproducer line (RPL-1) were studied for the expression of avian leukosis sarcoma (ALS) viruses. The MSB-1 line was free of all known endogenous expressions, including replicating virus (RAV-O), group-specific (gs) antigens, and chick helper factor (chf). The RPL-1 and HPRS-1 were positive for gs antigens and chf. The RPL-1 and MSB-1 lines showed no evidence of an exogenous DNA provirus by nucleic acid hybridization (HPRS-1 line was not tested for that DNA). All three lymphoblastoid cell lines were susceptible to exogenous infection with both sarcoma and leukosis viruses of subgroup A but varied in susceptibility to subgroups B and C. All were resistant to subgroups D and E.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001354:Avian Leukosis Virus / Q000254:growth & development* / Q000276:immunology; D001358:Avian Sarcoma Viruses / Q000254:growth & development / Q000276:immunology; D002460:Cell Line; D002472:Cell Transformation, Viral; D002645:Chickens; D008381:Herpesvirus 2, Gallid / Q000254:growth & development* / Q000276:immunology; D008380:Marek Disease / Q000382:microbiology*
chemical_list: D000956:Antigens, Viral