title: Phosphorus 31 NMR of neuroblastoma clonal lines. Effect of cell confluency state and dibutyryl cyclic AMP.
abstract: Phosphorus nuclear magnetic resonance is used to study changes in the levels of the major phosphate-containing intermediary metabolites concomitant with induced cellular differentiation in the N-18 and C-46 neuroblastoma clonal lines. The study reveals differences between the 31P-NMR profiles of the two clonal lines and also striking differences attendant to dibutyryl cAMP-mediated morphological differentiation in the N-18 clone. Phosphorus-31 NMR would appear to provide a new technique with which to study genetic differentiation.
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division; D002999:Clone Cells; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000032:analysis; D010710:Phosphates / Q000032:analysis; D010758:Phosphorus
chemical_list: D009943:Organophosphorus Compounds; D010710:Phosphates; D010758:Phosphorus; D003994:Bucladesine