Role of cytoskeletal elements in cytochalasin E-induced superoxide production by human polymorphonuclear leukocytes.
The release of superoxide anions from human polymorphonuclear leukocytes induced by cytochalasin E was greatly enhanced by the pretreatment of the cells either with deuterium oxide or with concanavalin A. Colchicine, vinblastine and cyclic AMP inhibited the release. Cytochalasins A and B also suppressed the superoxide release. These observations suggest the involvement of microfilament-microtubule system in the production and release of superoxide anions induced by cytochalasin E.
D003078:Colchicine / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D003572:Cytochalasins / Q000494:pharmacology*; D003599:Cytoskeleton / Q000502:physiology; D003903:Deuterium / Q000494:pharmacology; D006801:Humans; D008870:Microtubules / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000097:blood*; D014747:Vinblastine / Q000494:pharmacology
D003572:Cytochalasins; D003208:Concanavalin A; D013481:Superoxides; D003571:Cytochalasin B; D014747:Vinblastine; D003903:Deuterium; D000242:Cyclic AMP; D013482:Superoxide Dismutase; D010100:Oxygen; D003078:Colchicine