Attenuation of hydrochlorothiazide-induced hypokalemia in dogs by a beta-adrenergic blocking drug, timolol.
Hydrochlorothiazide, administered at 1, 3 and 9 mg/kg/day p.o. for 4 days, produced a dose-dependent lowering of plasma potassium and an elevation in plasma renin activity in unanesthetized dogs. When plasma renin activity was suppressed in diuretic-treated dogs by the potent beta-adrenergic receptor-blocking drug, timolol (0.5, 2 mg/kg/day p.o. for 4 days), the hypokalemia and hyperreninemia were significantly less pronounced. The data suggest that beta-adrenergic blocking drugs can be used to antagonize these side effects of diuretics.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005260:Female; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D007008:Hypokalemia / Q000139:chemically induced*; D008297:Male; D011188:Potassium / Q000097:blood; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood
D000319:Adrenergic beta-Antagonists; D006852:Hydrochlorothiazide; D012964:Sodium; D012083:Renin; D011188:Potassium