[3H]GABA binding in brains from Huntington's chorea patients: altered regulation by phospholipids?
Binding sites for tritum-labeled gamma-aminobutyric acid (GABA) in cerebellar cortex of Huntington's chorea patients have an increased affinity but unaltered maximum capacity as compared to binding sites in tissue from control patients. A similar binding pattern is produced in control membranes by treatment with Triton X-100, phospholipase C, or glycerophosphoethanolamine. Thus, it is likely that phospholipids or their metabolites regulate the accessibility of the GABA binding site and that this regulation is abnormal in Huntington's chorea.
D002525:Cerebellar Cortex / Q000378:metabolism*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D007700:Kinetics; D008563:Membrane Lipids; D010714:Phosphatidylethanolamines / Q000502:physiology; D011092:Polyethylene Glycols / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D008563:Membrane Lipids; D010714:Phosphatidylethanolamines; D017981:Receptors, Neurotransmitter; D011092:Polyethylene Glycols; D005680:gamma-Aminobutyric Acid