Development of second malignancies in rats after cure of acute leukemia L 5222 by single doses of 2-chloroethylnitrosoureas.
After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas.
D000818:Animals; D002330:Carmustine / Q000009:adverse effects*; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000473:pathology; D009380:Neoplasms, Nerve Tissue / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D051381:Rats
D009607:Nitrosourea Compounds; D002330:Carmustine