Neuromuscular blocking property of minocycline in the rabbit.
The neuromuscular blocking property of minocycline hydrochloride (MNC) was studied in 12 rabbits. In 2 of 6 animals, MNC, 60-160 mg/kg, alone caused a decrease in twitch tension. During partial neuromuscular blockade produced by a continuous infusion of pancuronium, the intravenous administration of MNC, 20--60 mg/kg, resulted in a dose-dependent decrease in twitch tension in 6 animals. MNC-induced or combined MNC-pancuronium-induced neuromuscular blockade was antagonized by calcium or by neostigmine.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008911:Minocycline / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology*
D013754:Tetracyclines; D008911:Minocycline