[Acquired idoxuridine resistance of herpes simplex virus. Clinical data (author's transl)].
The authors report two cases of severe herpetic keratitis and briefly discuss the possible mechanism of acquired idoxuridine resistance of herpes simplex virus. They believe that acquired resistance to IDU may be due to the treatment itself because of activity site of the inhibitor, i.e. the viral DNA.
D002648:Child; D004279:DNA, Viral; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007065:Idoxuridine / Q000494:pharmacology* / Q000627:therapeutic use; D007635:Keratitis, Dendritic / Q000188:drug therapy / Q000382:microbiology*; D018139:Simplexvirus / Q000187:drug effects*
D004279:DNA, Viral; D007065:Idoxuridine
Résistance acquise de l'herpes simplex virus à l'idoxuridine: discussion d'un fait clinique.