title: In vitro cultivation of human tumor tissues. II. Morphological and virological characterization of three cell lines.
abstract: Nineteen human tumors, mostly of sarcomatous nature, were cultured in vitro. Three cell lines were isolated and further characterized: MG-57 derived from a giant cell tumor, MG-63 derived from an osteosarcoma and MG-72 derived from a xanthohistiocytoma. The cell lines varied in morphology and growth pattern. An abnormal karyotype with marker chromosomes was present in Mg-63 and MG-72. None of the cell lines spontaneously produced detectable C-type virus particles. Stimulation with IUDR and dexamethasone also failed to induce detectable particle release.
mesh_terms: D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D005870:Giant Cell Tumors / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology; D006801:Humans; D009374:Neoplasms, Experimental / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D012190:Retroviridae / Q000302:isolation & purification; D012513:Sarcoma, Experimental / Q000473:pathology