The pharmacology of 14-hydroxyazidomorphine.
6-Deoxy-6-dihydroazido-14-hydroxyisomorphine (14-hydroxyazidomorphine) was synthesized, its analgesic potency in mice and rats, its antitussive effect in rats and its dependence liability in mice, rats and monkeys were studied. Azidomorphine the 14-nonhydroxylated parent molecule, morphine, hydromorphone and oxymorphone were used for comparison. 14-Hdroxyazidomorphine proved to be as potent an analgesic as azidomorphine, even more potent as an antitussive, and showed the same low tolerance and dependence capacity. It was 11-6 times less toxic than azidomorphine in mice and 6-5 times less toxic in rats.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009021:Morphine Dependence / Q000209:etiology; D009022:Morphine Derivatives / Q000494:pharmacology* / Q000633:toxicity; D010111:Oxymorphone / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000700:Analgesics; D000996:Antitussive Agents; D009022:Morphine Derivatives; D010111:Oxymorphone