Impairment of hormone dependent signal transfer by chronic SSPE virus infection.
In a CNS-derived cell line, the cellular response to hormonal stimulation, represented by the rise of intracellular cAMP levels, is impaired under the influence of a persisting neurotropic virus infection. This dysfunction is caused by the decrease in adenylate cyclase activity, most probably due to the virus-induced loss of active catalytic units.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000096:biosynthesis*; D005910:Glioma; D007545:Isoproterenol / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D013190:SSPE Virus / Q000254:growth & development*; D014779:Virus Replication
D011941:Receptors, Adrenergic; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol