[D-penicillamine in rheumatoid arthritis : hematological incidents and accidents (author's transl)].
From literature data and their own experience, the authors comment hematological complications, related to the use of D-penicillamine, mainly in theumatoïd arthritis. Hypereosinophilia is more common than thrombopenia, but, both complications are usually benign. Anemia alone is very rare. Leukopenia appears in 6% of treated patients, but pancytopenia is rare. Leukopenia and pancytopenia are the most severe complications, even fatal in some cases. The safest dose of D-penicillamine seems to be between 600 and 900 mg per day, provided that, however, regular hematological controls may be achieved.
D000740:Anemia / Q000139:chemically induced; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004802:Eosinophilia / Q000139:chemically induced; D006402:Hematologic Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D010198:Pancytopenia / Q000139:chemically induced; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced
D010396:Penicillamine
La D-pénicillamine dans la polyarthrite rhumatoide : incidents et accidents hématologiques.