The interaction between herpesvirus and oncornavirus of guineapigs: in vitro and in vivo studies.
In vitro, cultured guineapig doubly infected with both guineapig herpesvirus (GPHLV) and guineapig oncornavirus (GPOV) revealed pseudotype virus particles with oncornavirus morphology coated with GPHLV antigen as detected by immunoferritin electron microscopy. In vivo, infection of Hartley guineapigs with both GPHLV and GPOV induced hyperplasia in lymph-nodes in a higher percentage of animals than in those that received only one virus type. In addition, experimental GPHLV infection of strain 2 guineapigs caused some delay in the development of L2C leukaemia in inoculated animals.
D000818:Animals; D000956:Antigens, Viral; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006168:Guinea Pigs; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D006965:Hyperplasia; D007942:Leukemia, Experimental / Q000150:complications* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D012190:Retroviridae / Q000276:immunology; D014412:Tumor Virus Infections / Q000150:complications*; D014779:Virus Replication
D000956:Antigens, Viral