title: On the effects of thiamphenicol and chloramphenicol on nucleic acid and protein synthesis in rabbit bone marrow cells in vivo and in vitro.
abstract: Besides the in vivo effects of thiamphenicol (TAP), this study shows the in vitro effects of TAP and D- and L-threo-chloramphenicol (CAP) on the synthesis of DNA, RNA, protein and hemoglobin in marrow cells and reticulocytes. The experiments make it likely that TAP exerts its action on a stem cell in a proliferating phase.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D002701:Chloramphenicol / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D003576:Electron Transport Complex IV / Q000378:metabolism; D006454:Hemoglobins / Q000096:biosynthesis; D066298:In Vitro Techniques; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D013237:Stereoisomerism; D013839:Thiamphenicol / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D012313:RNA; D002701:Chloramphenicol; D004247:DNA; D003576:Electron Transport Complex IV; D013839:Thiamphenicol