Optic neuritis: local synthesis in the central nervous system of oligoclonal antibodies to measles, mumps, rubella, and herpes simplex viruses.
Antibodies to measles, mumps, rubella and herpes simplex type 1 viruses in serum and CSF of 10 patients with acute monosymptomatic optic neuritis were characterized by imprint electro-immunofixation (IEIF). Comparisons of the IEIF antibody patterns in serum and CSF indicated that a local synthesis in the central nervous system of oligoclonal virus antibodies took place in five of the 10 patients. Three of the five patients had a local synthesis of antibody to more than one type of virus. Oligoclonal IgG was detected by agarose electrophoresis of the CSF in four of the five patients with a local synthesis of virus antibodies. There was, however, no association between the locally synthesized antibodies and the oligoclonal CSF IgG, indicating that they account for only a minor fraction of the locally synthesized IgG in these patients. In the fifth patient, distinct fractions of locally synthesized virus-specific oligoclonal Ig were detected by the IEIF method, although the agarose electrophoresis showed a normal pattern of CSF IgG.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis* / Q000134:cerebrospinal fluid; D001921:Brain / Q000276:immunology*; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007158:Immunologic Techniques; D008297:Male; D008459:Measles virus / Q000276:immunology; D008875:Middle Aged; D009902:Optic Neuritis / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000382:microbiology; D012412:Rubella virus / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology
D000914:Antibodies, Viral; D007074:Immunoglobulin G