Lack of inhibition of ACTH-induced aldosterone stimulation by des-asp1-,ileu8-angiotensin II in man.
In 5 normal men an intravenous injection of 0.5 mg of synthetic 1-24 ACTH caused a significant increase in plasma aldosterone and a simultaneous intravenous infusion of 600 ng/kg/min of des-asp1-, ileu8-angiotensin II (AIIIA) did not inhibit this increase. Since this dose of AIIIA is known to inhibit an angiotensin II-induced increase in plasma aldosterone in normal men, the present results suggest that the ACTH-induced aldosterone stimulation is mediated by an adrenocortical receptor which is different from angiotensin II receptors.
D000324:Adrenocorticotropic Hormone; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D000805:Angiotensin III / Q000031:analogs & derivatives*; D006801:Humans; D007532:Isoleucine / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood
D007532:Isoleucine; D000804:Angiotensin II; D000805:Angiotensin III; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012083:Renin