title: The prevention of pig-bel in Papua New Guinea.
abstract: In many Highlands hospitals pig-bel is the commonest cause of death in children over 12 months of age. In a double blind controlled trial in Sina Sina we have shown that Clostridium welchii type C beta toxoid (beta toxoid) protects against pig-bel (p < 0.02). Of 2,538 children given beta toxoid, two developed pig-bel in the following two years. Seventeen of 2,532 control children vaccinated with tetanus toxoid developed pig-bel. We suggest that beta toxoid be given to Highlands children at two, four and six months of age. Boosters may be needed. Health services in the Highlands need to be improved so that this vaccine can be effectively delivered.
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003016:Clostridium perfringens / Q000276:immunology*; D004311:Double-Blind Method; D004751:Enteritis / Q000175:diagnosis / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D008297:Male; D008460:Meat / Q000009:adverse effects*; D009512:New Guinea; D013552:Swine; D014121:Toxoids / Q000008:administration & dosage; D014611:Vaccination
chemical_list: D014121:Toxoids