[Post-hepatitic aplasia treated by grafts of allogenic bone marrow. Remission for more than 2 years. Persistance of a total hematopoietic chimera. Graft versus host reaction].
A successfull bone marrow transplant was achieved in a case of post hepatitic aplastic anemia after cyclophosphamide immunosuppression. Caryotype analysis, erythrocytic phenotype and IgG Gm allotype demonstrated evidence of complete chimerism. Anti-thymocyte serum undoubtly was able to suppress a life threatening episode of graft versus host reaction. Severe long lasting skin lesions are now persisting 2 years after the graft.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001789:Blood Group Antigens; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003289:Convalescence; D003298:Coombs Test; D003520:Cyclophosphamide / Q000627:therapeutic use; D005500:Follow-Up Studies; D006087:Graft vs Host Reaction; D006417:Hematuria / Q000209:etiology; D006506:Hepatitis A / Q000150:complications*; D006649:Histocompatibility Antigens; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007621:Karyotyping; D008297:Male; D011183:Postoperative Complications; D012075:Remission, Spontaneous; D018805:Sepsis / Q000209:etiology; D014184:Transplantation, Homologous / Q000379:methods
D000961:Antilymphocyte Serum; D001789:Blood Group Antigens; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D003520:Cyclophosphamide
Aplasie post-hépatitique traitée par greffe de moelle osseuse allogénique. Guérison depuis plus de deux ans. Persistance d'une chimère hématopoiétique totale. Réaction de greffon contre l'hôte