Sex hormone binding globulin capacity and postmenopausal hormone replacement therapy.
The sex hormone binding globulin (SHBG) capacity was measured in 26 normal untreated postmenopausal women and 10 postmenopausal women taking different types of hormone replacement therapy. The patients on hormone replacement therapy had significantly higher levels of SHBG than postmenopausal women (p less than 0.001) and also significantly higher levels than 52 normal ovulating women studied previously (Pogmore and Jequier, 1979; p less than 0.02). This suggests that postmenopausal women on hormone therapy are being overtreated.
D000293:Adolescent; D000368:Aged; D004338:Drug Combinations; D045166:Estradiol Congeners / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D045167:Progesterone Congeners / Q000627:therapeutic use; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D014424:Turner Syndrome / Q000097:blood / Q000188:drug therapy
D004338:Drug Combinations; D045166:Estradiol Congeners; D004966:Estrogens, Conjugated (USP); D006728:Hormones; D045167:Progesterone Congeners; D012738:Sex Hormone-Binding Globulin