Mecillinam in enteric fever.
Twelve consecutive patients with enteric fever entered a trial of 14 days' treatment with mecillinam. Only three patients became afebrile within three days; four continued unimproved with fever and toxaemia for seven to nine days, when treatment was changed to chloramphenicol with good results. In one case the fever did not settle until the 13th day, and five days later the patient had a clinical relapse. Although all organisms recovered were fully sensitive to mecillinam, this drug is not an effective or consistent treatment for enteric fever.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000560:Amdinocillin / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000627:therapeutic use*; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy* / Q000382:microbiology
D010397:Penicillanic Acid; D000560:Amdinocillin