The binding of 125I-TSH to thyroid cell receptors previously deformed (in neonatal age) by gonadotropin treatment.
Single gonadotropin treatment of newborn rats caused a 63-71% decrease of TSH-binding on isolated thyroid cells prepared from thyroid glands of both 6- and 13-month-old animals. This fact points out that: (1) in newborn animals the hormone receptors are still plastic and deformable and (2) the damaging effect of the analogous hormone manifests itself at the receptor level.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D006062:Gonadotropins / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013961:Thyroid Gland / Q000166:cytology / Q000294:innervation / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism*
D006062:Gonadotropins; D011956:Receptors, Cell Surface; D013972:Thyrotropin