Ocular anti-inflammatory effect of fenoprofen. Dose-response study.
An experimental rabbit uveitis model was used to establish a dose response range for topical administration of fenoprofen (dl-2(3-phenoxyphenyl) propionic acid. The 0.3% concentrate group was not distinguishable from the untreated group, and 3% concentrate proved highly irritating. Fenoprofen 1%, pH 6.4, proved most efficacious and had an effect comparable to dexamethasone phosphate 0.1%, seen in a previous study.
D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005279:Fenoprofen / Q000008:administration & dosage* / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D010666:Phenylpropionates / Q000008:administration & dosage*; D011817:Rabbits; D014605:Uveitis / Q000188:drug therapy*
D010666:Phenylpropionates; D005279:Fenoprofen