Free plasma 11-hydroxycorticosteroids and the response to beta1-24-corticotrophin in regular haemodialysis patients.
The adrenocortical function of 59 patients on regular hemodialysis treatment was tested on 105 occasions by measuring the 30-min response of free plasma 11-hydroxycorticosteroids (11-OHCS) after intramuscular injection of 0.25 mg Synacthen (beta1-24-corticotrophin). The morning basal levels of 11-OHCS were within the normal range. The increase of 11-OHCS after injection of Synacthen was less than normal in 25% of the patients. In 9 patients with a low response an extended Synacthen test was performed. This caused a normal increase in plasma 11-OHCS but the response came later than in normal persons. After 0.25 mg Synacthen intramuscularly the 30-min response of 11-OHCS seemed to be lower on the first day than on the second day after dialysis. The present study supports the view that the pituitary-adrenocortical system is essentially intact in patients on regular hemodialysis treatment.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology; D000304:Adrenal Cortex Function Tests; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000328:Adult; D002648:Child; D003366:Cosyntropin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D006435:Renal Dialysis / Q000009:adverse effects*
D015062:11-Hydroxycorticosteroids; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone