[Prevention and therapy of respiratory distress syndrome in premature infants by means of bromhexine metabolite VIII. Animal experimental studies on the therapeutic efficacy of bromhexine metabolite VIII in premature respiratory distress syndrome].
In preparing a clinical study 14C-labelled bromhexine metabolite VIII was applied intraamnially in animal experiments. The distribution was measured in different maternal and fetal organs by thinlayer chromatography and autoradiography. A complete placental passage was found in both directions. An organspecific accumulation in the fetal lungs could not be demonstrated.
D000551:Ambroxol / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D000653:Amniotic Fluid / Q000032:analysis; D000818:Animals; D001646:Bile / Q000032:analysis; D001964:Bromhexine / Q000031:analogs & derivatives*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*; D013552:Swine
D000551:Ambroxol; D001964:Bromhexine
Prophylaxe und Therapie des Atemnot-Syndroms bei Frühgebärenden mit Bromhexine Metabolit VIII. Tierexperimentelle Untersuchungen zur therapeutischen Wirksamkeit von Bromhexine Metabolit VIII beim Atemnotsyndrom Frühgeborener.