[Effects of an antiinflammatory drug (diclofenac) in primary chronic glomerulo-nephritis (author's transl)].
Chronic Glomerulo-Nephritis (GN) are among nephrologic diseases, frequent and severe. In most of them immunological process are involved. Non steroïdal antiinflammatory drugs are able to reduce proteinuria, mainly in Membrano-Proliferative GN and IgA Mesengial GN. A protracted administration is necessary for proteinuria reappeared when treatment is interrupted. With long term administration renal prognosis is improved and severe renal insufficiency delayed. Among active antiinflammatory drugs (indometacine, ketoprofen, diclofenac, flurbiprofen, etc.) diclofenac is one of the best tolerated.
D000328:Adult; D001799:Blood Sedimentation; D003404:Creatinine / Q000097:blood; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000627:therapeutic use*; D011507:Proteinuria / Q000188:drug therapy
D005338:Fibrin Fibrinogen Degradation Products; D010648:Phenylacetates; D004008:Diclofenac; D003404:Creatinine
Action du diclofénac dans les glomérulonéphrites primitives chroniques.