14q+ marker chromosome in an EBV-genome-negative lymph node without signs of malignancy in a patient with EBV-genome-positive nasopharyngeal carcinoma.
In a patient with an EBV-genome-positive nasopharyngeal carcinoma, an EBV-genome-negative inguinal lymph node without histological evidence of malignant lymphoma or metastatic carcinoma growth was found to contain a 14q+ marker chromosome, identified as an 8;14 translocation, in all cells analyzed. This observation indicates that chromosome aberrations may precede histological signs of malignancy. The possible implication of this finding in relation to the postulated role of the 14q+ marker and lymphoma development is discussed.
D000328:Adult; D000956:Antigens, Viral; D002901:Chromosomes, Human, 13-15; D004279:DNA, Viral; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000648:ultrastructure*; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral; D014178:Translocation, Genetic
D000956:Antigens, Viral; D004279:DNA, Viral; D012367:RNA, Viral