Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus.
Biochemical evidence supporting the sympathetic control of cerebrospinal fluid production has been obtained through identification of a specific beta-adrenergic-sensitive adenylate cyclase in the choroid plexus. The enzyme, which is localized in the secretory epithelium, is activated by low concentrations of isoproterenol and norepinephrine and appears separate from beta-adrenergic-sensitive adenylate cyclase present in cerebral blood vessels.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002415:Cats; D002417:Cattle; D002555:Cerebrospinal Fluid / Q000378:metabolism; D002560:Cerebrovascular Circulation; D002831:Choroid Plexus / Q000201:enzymology* / Q000378:metabolism; D004285:Dogs; D004789:Enzyme Activation / Q000187:drug effects; D004848:Epithelium / Q000201:enzymology; D007545:Isoproterenol / Q000494:pharmacology; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000262:Adenylyl Cyclases; D007545:Isoproterenol