The role of the kidney in vitamin D metabolism.
The kidney should be regarded as an organ of central importance in the regulation of calcium metabolism. Its secretion product, 1 alpha,25(OH)2D3, is regulated by several factors, including the calcium and phosphorus content of the diet, parathyroid hormone and the level of 1 alpha,25(OH)2D3 itself. The main occasions in health where 1 alpha,25(OH)2D3 secretion is enhanced are during growth and reproduction. In these situations the secretion of this new renal hormone is under at least partial control of growth hormone and prolactin.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002762:Cholecalciferol / Q000378:metabolism*; D002776:Cholestanes / Q000378:metabolism; D003684:Dehydrocholesterols / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007774:Lactation; D008297:Male; D011247:Pregnancy; D011388:Prolactin / Q000502:physiology; D051381:Rats
D002776:Cholestanes; D003684:Dehydrocholesterols; D002762:Cholecalciferol; D011388:Prolactin; D013006:Growth Hormone; D002118:Calcium