Distribution of NAD(P)H-dependent cytochrome P-450 mixed function oxidase system in the brush border membrane of rabbit kidney cortex.
Optical and magnetic studies were made on subfractions of rabbit kidney cortex. Cytochrome P-450 and cytochrome b5-dependent mixed function oxidase systems were localized mainly in the brush border membranes and microsomes. Cytochrome P-450-dependent mixed function oxidases in the membranes comprised both an NADPH-dependent system and an NADH-dependent system.
D000818:Animals; D002458:Cell Fractionation; D002462:Cell Membrane / Q000201:enzymology; D003577:Cytochrome P-450 Enzyme System; D003580:Cytochromes / Q000032:analysis; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport; D007672:Kidney Cortex / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D008854:Microscopy, Electron; D008861:Microsomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000032:analysis*; D009243:NAD; D009249:NADP; D010088:Oxidoreductases / Q000032:analysis*; D011506:Proteins / Q000032:analysis; D011817:Rabbits; D013057:Spectrum Analysis
D003580:Cytochromes; D011506:Proteins; D009243:NAD; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases