Depressed prostaglandin release from peritoneal cells induced by a T cell adjuvant, lentinan.
PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two beta (1-3) glucans, the antitumor active lentinan and the inactive pachyman, 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.
D000276:Adjuvants, Immunologic; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D000242:Cyclic AMP / Q000032:analysis; D007912:Lentinan / Q000494:pharmacology*; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D007912:Lentinan; D000242:Cyclic AMP