title: [Trials to obtain a hyperimmune serum against bovine mucosal disease-virus diarrhea].
abstract: Obtained are two types of hyperimmune sera against the virus of the mucous disease--viral diarrhea (MD--VD) by means of subcutaneous and venous hyperimmunization of cattle with a live viral suspension: (a) A polyvariant hyperimmune serum, obtained by the use of four local and reference strains of the MD--VD virus with a neutralization titre against the Nadl strain of 1 : 1280. (b) Monovariant hyperimmune serum, prepared by the use of a reference strain of the MD--VD virus with a neutralization titre against the Nadl strain of 1 : 1280. On testing experimental calves and application in practice, it has not been established that the polyvariant serum possesses a marked protective effect at a dose of 1 cm3/kg.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000008:administration & dosage; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology* / Q000517:prevention & control; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D004341:Drug Evaluation / Q000662:veterinary; D007106:Immune Sera / Q000302:isolation & purification*; D007114:Immunization / Q000662:veterinary; D012328:RNA Viruses / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D007106:Immune Sera
vernacular_title: Opiti za poluchavane na khiperimunen serum protiv mukozna bolest-virusna diareia po govedata.