[Immunocytochemical similarities between basophilic and chromophobe pituitary adenomas. Light and electron microscopic study of 13 cases (author's transl)].
ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. The antisera gave various positive reactions in both of these groups. ACTH, alpha MSH and enkephalins were predominant. The reason why these hormones are clinically silent in "chromophobe" or, even, basophilic adenomas is still to be elucidated.
D000237:Adenoma, Basophil / Q000032:analysis*; D000238:Adenoma, Chromophobe / Q000032:analysis*; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D003480:Cushing Syndrome / Q000378:metabolism; D004723:Endorphins / Q000032:analysis; D004745:Enkephalins / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D010911:Pituitary Neoplasms / Q000032:analysis*; D008083:beta-Lipotropin / Q000032:analysis
D004723:Endorphins; D004745:Enkephalins; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin
Analogies immunocytochimiques des adénomes hypophysaires de la maladie de Cushing et des adénomes "non fonctionnels" (adénomes chromophobes) de l'hypophyse. A propos de 13 cas.