Reversal of oliguria and renal cortical ischemia of hemorrhagic shock in the dog with tris (hydroxymethyl) amino methane (THAM). Hemodynamic studies.
We investigated the functional and hemodynamic effects on the kidney of tris (hydroxymethyl) amino methane (THAM) infusion during sustained hemorrhagic hypotension in dogs. The large osmotic load introduced into the vascular compartment during hemorrhagic hypotension resulted in a marked reduction in systemic vascular resistance and a return of cardiac output, total renal blood flow, and the renal arteriographic pattern to normal range. The observed diuresis is probably due to an osmotic effect, because the glomerular filtration rate remains significantly depressed. Anatomical assignment of the mathematical components of the xenon washout curve led to an assessment of intrarenal blood flow distribution that was at variance with the arteriographic pattern and the intrarenal distribution of tagged microspheres.
D000818:Animals; D001002:Anuria / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology; D007672:Kidney Cortex / Q000098:blood supply*; D009846:Oliguria / Q000188:drug therapy*; D009994:Osmolar Concentration; D011859:Radiography; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery / Q000000981:diagnostic imaging; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D014325:Tromethamine / Q000494:pharmacology / Q000627:therapeutic use*; D014655:Vascular Resistance / Q000187:drug effects
D014325:Tromethamine