title: [Substances having antiviral activity. IX. Synthesis and antiviral activity of 1-acyl-2-halo-3-formylindole thiosemicarbazones].
abstract: Some thiosemicarbazones of 1-acyl-2-chloro-3-formylindoles were synthesized and investigated for antiviral activity against vaccinia virus, HID stock and parainfluenza virus type 3 HA-I/CR-8 stock. Evidence of antiviral activity was found only against vaccinia virus, and was particular significant with the m-substituted 1-benzoyl-2-chloro-3-formylindoles. The first results of 2-substitution of chlorine by bromine in the indole skeleton, are reported.
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D013882:Thiosemicarbazones
vernacular_title: Ricerche su sostanze ad attività antivirale. Nota IX - Sintesi ed attività antivirale di tiosemicarbazoni di 1-acil-2-alogeno-3-formilindoli.