Divergent effects of prostaglandin synthesis inhibitors on pulmonary cyclic 3', 5'-adenosine monophosphate and cyclic 3', 5'-guanosine monophosphate levels in untreated and histamine sensitized mice.
Prostaglandin synthesis inhibitors (indomethacin and acetylsalicylic acid) were studied in mice under control conditions and during a period of B. pertussis-induced increased sensitivity to histamine. These compounds were employed to inhibit the generation of prostaglandins and thus allow for analysis of prostaglandin participation in the heightened accumulation of pulmonary cyclic nucleotides in pertussis-sensitized mice. The results show that the two non-steroid antiinflammatory agents studied caused a reduction in basal cyclic GMP levels in pulmonary tissue of mice. Cyclic AMP levels were unaltered. Histamine raised cyclic  GMP levels in sensitized mice even in the presence of cyclo-oxygenase inhibition, but these rises never exceeded basal levels in mice that had not received cyclo-oxygenase inhibitors. It can be concluded that prostaglandin synthesis inhibitors suppress the cyclic GMP system.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D010567:Pertussis Vaccine / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*
D010567:Pertussis Vaccine; D011453:Prostaglandins; D006632:Histamine; D000242:Cyclic AMP; D006152:Cyclic GMP; D001241:Aspirin; D007213:Indomethacin