[Comparative experimental studies of the combined use of vaccines, interferon and interferon inducers in neurovirus infections].
Comparative investigations of the combined use of vaccines and interferon in tick-borne encephalitis, herpes, and acute encephalomyelitis of man showed that up to 78% of animal protection against 10--50 LD50 of intraperitoneally inoculated viruses could be achieved. Vaccination alone provided up to 56% survival of the infected mice, while administration of interferon subcutaneously or intraperitoneally in a dose of 800 units (53,300 units per 1 kilo body weight) 18--20 hours before virus gave a survival rate of 36%. The use of vaccine in combination with an interferon inducer, phage of f2 RNA, in tick-borne encephalitis gave up to 75% survival of the infected mice. Four hours after administration, interferon could be detected in mouse sera in a concentration up to 640 units/ml which in immune mice accumulated more rapidly and remained at a higher level 18 hours after inoculation of the inducer.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control; D004679:Encephalomyelitis / Q000517:prevention & control; D006566:Herpesviridae Infections / Q000517:prevention & control; D007114:Immunization; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000008:administration & dosage*; D051379:Mice; D010919:Placebos; D013997:Time Factors; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage*; D014777:Virus Diseases / Q000517:prevention & control*
D007369:Interferon Inducers; D010919:Placebos; D014765:Viral Vaccines; D007372:Interferons
Sravnitel'nye issledovaniia po éksperimental'nomu izucheniiu sochetannogo primeneniia vaktsin, interferona i induktorov interferona pri nekotorykh neĭrovirusnykh infektsiiakh.