TSH-receptor antibodies, HLA B8 and thyroid autoantibodies in patients with Graves' disease in therapeutically induced euthyroidism.
The prevalence of TSH-receptor antibodies and of thyroid autoantibodies was studied in 48 HLA-typed patients with Graves' disease, who were in an euthyroid state after antithyroid therapy with methimazole. TSH-receptor antibodies, which were found in 35% of the patients, did not correlate with the positivity of HLA B8. By contrast the persistence of thyroid microsomal antibodies was significantly associated with HLA B8.
D000906:Antibodies; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D008713:Methimazole / Q000627:therapeutic use; D008861:Microsomes / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013972:Thyrotropin / Q000378:metabolism*
D000906:Antibodies; D006680:HLA Antigens; D007518:Isoantibodies; D011956:Receptors, Cell Surface; D008713:Methimazole; D013972:Thyrotropin