Absence of dopamine sensitive adenylate cyclase in the A10 region, the origin of mesolimbic dopamine neurones.
Dopamine (DA) failed to stimulate the adenylate cyclase of the mesolimbic A10 DA nerve cell body area, in contrast to tis activating effect in the nigrostriatal A9 DA cell body area. The enzyme was stimulated by GMPPNP (a GTP analog) and NaF. This indicates the absence in the A 10 cell area of DA receptors with functional coupling on adenylate cyclase, in contrast to the A9 cell area where such DA receptors are believed to be located on afferent axon terminals.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism* / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005459:Fluorides / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D008032:Limbic System / Q000201:enzymology*; D008297:Male; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013378:Substantia Nigra / Q000201:enzymology; D013681:Tegmentum Mesencephali / Q000201:enzymology
D017981:Receptors, Neurotransmitter; D006165:Guanylyl Imidodiphosphate; D000262:Adenylyl Cyclases; D005459:Fluorides; D004298:Dopamine