title: Deficient thyroid peroxidase causing organification defect and goitrous hypothyroidism.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D006044:Goiter, Nodular / Q000378:metabolism*; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism*; D007223:Infant; D007453:Iodide Peroxidase / Q000172:deficiency*; D007454:Iodides / Q000378:metabolism*; D007455:Iodine / Q000032:analysis; D007467:Iodoproteins / Q000097:blood; D008297:Male; D007470:Monoiodotyrosine / Q000032:analysis; D010472:Perchlorates / Q000494:pharmacology; D010544:Peroxidases / Q000172:deficiency*; D013954:Thyroglobulin / Q000032:analysis / Q000378:metabolism; D013961:Thyroid Gland / Q000032:analysis / Q000033:anatomy & histology / Q000378:metabolism*; D013974:Thyroxine / Q000032:analysis; D014284:Triiodothyronine / Q000032:analysis
chemical_list: D007454:Iodides; D007467:Iodoproteins; D010472:Perchlorates; D014284:Triiodothyronine; D006427:Hemin; D013954:Thyroglobulin; D007455:Iodine; D010544:Peroxidases; D007453:Iodide Peroxidase; D007470:Monoiodotyrosine; D013974:Thyroxine