[Reinnervation mechanism of skeletal muscles damaged by botulism toxin].
Reinnervation by botulinus toxin impaired motor nerve implantation was investigated in rat experiments with a purpose of elucidating conditions for regeneration of nerve fibers in the area of botulinic paralysis. Administration of the sublethal dose of toxin into the limb accelerated synaptogenesis of the nerve implanted. The latter exerts a normalizing effect on the muscular tissue and polarization level of its fibers.
D000818:Animals; D001905:Botulinum Toxins / Q000633:toxicity*; D005260:Female; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000294:innervation*; D009416:Nerve Regeneration / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects; D051381:Rats; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013979:Tibial Nerve / Q000637:transplantation; D013997:Time Factors
D001905:Botulinum Toxins
K mekhanizmu reinnervatsii skeletnykh myshts, povrezhdennykh toksinom botulizma.