title: Mesoionic xanthine analogs as inhibitors of cyclic AMP phosphodiesterase.
abstract: Several derivatives of two mesoionic xanthine analogs, mesoionic thiazolo[3,2-alpha]pyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-alpha]pyrimidine-5,7-diones, were synthesized and evaluated as inhibitors of cyclic AMP phosphodiesterase. A significant number of these compounds demonstrated theophylline-like activity.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014970:Xanthines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D013844:Thiazoles; D014970:Xanthines; D015105:3',5'-Cyclic-AMP Phosphodiesterases