title: [Effect of small amounts of methylmercury on embryogenesis and certain biochemical indices].
abstract: It was established in experiments on Wistar rats that oral methyl mercuric iodide at doses of 0.85, 0.64, 0.42 and 0.21 mg/kg daily exerts no teratogenic or embryotoxic action on the progeny. However, administration of methyl mercuric iodide at doses of 0.85 and 0.64 mg/kg produced in females a significant decrease in the SH-group content in renal and cerebral tissues, in the activity of acetylcholine esterase in the cerebellum (by 18-48%) and a rise in the activity of glucose-6-phosphatase in the kidneys (by 48-70%). The doses of 0.42 and 0.21 mg/kg administered at various periods of pregnancy, did not exert any effect on the body of females under experimental conditions. These findings are supported to a certain measure by the results of examination of a 2-month progeny of the animals given 0.21 mg/kg methyl mercuric iodide daily. The biochemical parameters of these animals did not differ from those of the control ones.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002531:Cerebellum / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007454:Iodides / Q000633:toxicity*; D007668:Kidney / Q000201:enzymology; D008431:Maternal-Fetal Exchange; D008767:Methylmercury Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013723:Teratogens
chemical_list: D007454:Iodides; D008767:Methylmercury Compounds; D013723:Teratogens; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D005952:Glucose-6-Phosphatase
vernacular_title: Vliianie malykh kolichestv metilrtuti na émbriogenez i nekotorye biokhimicheskie pokazateli.