Results of adrenal surgery in patients with hypertension, aldosterone excess, and low plasma renin concentration.
Fifty patients with hypertension, aldosterone excess, and low plasma renin concentration underwent adrenal surgery.  There was a highly significant fall in mean systolic and diastolic pressures after the operation.  The mean postoperative diastolic pressure fell to strictly normal levels, however, in only 19 out of 38 patients from whom an adrenocortical adenoma was removed and in only two out of 10 non-tumour patients.  There was a significant correlation between the fall in blood pressure during spironolactone treatment and after adrenal surgery though levels were generally slightly lower during the former therapy. It is suggested that removal of an aldosterone-producing adenoma is the treatment of choice provided a good preoperative hypotensive response to spironolactone occurs, while the treatment of choice for non-tumour patients is often long-term spironolactone.
D000236:Adenoma / Q000601:surgery; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D000368:Aged; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood; D013148:Spironolactone / Q000627:therapeutic use; D014508:Urea / Q000097:blood
D000804:Angiotensin II; D002245:Carbon Dioxide; D013148:Spironolactone; D014508:Urea; D012964:Sodium; D012083:Renin; D011188:Potassium