Use of propranolol in dysfunctional labour.
Labour pains associated with fear and anxiety increase the blood level of catecholamines. This in turn causes dysfunctional labour due to the weak uterine contractions which follow stimulation of uterine adrenergic beta receptors. Intravenous propranolol was administered to ten primigravidae with typical dysfunctional labour. This was shortly followed by normal uterine activity and delivery without any significant maternal or fetal complications. To the best of our knowledge this is the first attempt to treat dysfunctional labour by the intravenous administration of a beta-blocking agent, and our preliminary results are encouraging.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D001007:Anxiety; D001034:Apgar Score; D001724:Birth Weight; D001919:Bradycardia / Q000150:complications / Q000188:drug therapy; D002395:Catecholamines / Q000097:blood; D004106:Dilatation; D005239:Fear; D005260:Female; D005318:Fetal Heart / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007745:Labor Onset; D007749:Labor Stage, Third; D007744:Obstetric Labor Complications / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D011433:Propranolol