Effect of veratrum alkaloids on right and left atrial receptors in the cat.
1. The effects of veriloid and veratridine on right and left atrial receptors have been studied in cats. 2. Threshold doses of these drugs for right atrial receptors were found to be almost twice those for left atrial receptors. Beyond threshold doses, however, the dose-response curves were similar. 3. The sensitivity of left atrial receptors to veratridine was not altered by an increase in PCO2 and/or decrease in PO2 of left atrial blood. Therefore, the difference in the behaviour of left and right atrial receptors to these drugs is not due to the differences in PO2 and PCO2 of blood in the two atria. They are more likely to be a feature of the regenerative  regions of the receptors.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002415:Cats; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D010100:Oxygen / Q000097:blood; D011955:Receptors, Drug / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014704:Veratrum Alkaloids / Q000494:pharmacology*
D011955:Receptors, Drug; D014704:Veratrum Alkaloids; D002245:Carbon Dioxide; D010100:Oxygen