[Effect of single exposure to the carcinogen 4-dimethylaminoazobenzene on several properties of rat liver mitochondria].
The hepatospecific carcinogen 4-dimethylaminoazobenzene (DAB), applied as a single interperitoneal injection, induced no changes in the activity of mitochondrial and cytoplasmic malate-dehydrogenase in the rat liver. The same carcinogen and non-carcinogenic isomer 4-diethylaminoazobenzene brought about decreased activity of cytochromeoxidase in isolated rat liver mitochondria. During 18 days after a single interperitoneal injection of DAB the swelling-contraction properties of isolated liver mitochondria were seen altered in the presence of succinate and ATP whereas DAB exerted no influence on mitochondria from the kidney, which organ is not a target-tissue for carcinogenic action.
D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism*; D007668:Kidney / Q000648:ultrastructure; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D051381:Rats; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology*
D004124:p-Dimethylaminoazobenzene; D008291:Malate Dehydrogenase; D003576:Electron Transport Complex IV
Vliianie odnokratnogo vozdeĭstviia kantserogenom 4-dimetilaminoazobenzolom na nekotorye svoĭstva mitokhondriĭ pecheni krys.