Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.
In 12 patients with different posterior fossa tumours the concentrations of homovanillic acid (HVA) and of 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid from the lateral ventricles. All patients had obstructive hydrocephalus. Patients with a clear increase of 5-HIAA/HVA ratio in the ventricular CSF have died subsequently. This feature may have a diagnostic value, and indicates the prevalence of serotoninergic neurones in patients with obstructive hydrocephalus with fatal course after surgery.
D000328:Adult; D001254:Astrocytoma / Q000134:cerebrospinal fluid; D002528:Cerebellar Neoplasms / Q000134:cerebrospinal fluid; D002551:Cerebral Ventricle Neoplasms / Q000134:cerebrospinal fluid*; D004806:Ependymoma / Q000134:cerebrospinal fluid; D005260:Female; D005909:Glioblastoma / Q000134:cerebrospinal fluid; D006394:Hemangiosarcoma / Q000134:cerebrospinal fluid; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid*; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid; D008579:Meningioma / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009442:Neurilemmoma / Q000134:cerebrospinal fluid; D010648:Phenylacetates / Q000134:cerebrospinal fluid*
D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid