title: Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol.
abstract: Sixty percent of the male offspring from pregnant mice treated with diethylstilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal or fibrotic testes, or both. Additionally, nodular masses in the ampullary region of the reproductive tract were observed in 6 of 24 animals; one of these appeared to be preneoplastic.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D003456:Cryptorchidism / Q000139:chemically induced; D004054:Diethylstilbestrol / Q000633:toxicity*; D004822:Epididymis / Q000002:abnormalities*; D005260:Female; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D013737:Testis / Q000002:abnormalities* / Q000196:embryology
chemical_list: D004054:Diethylstilbestrol