title: Prevention of brain extension in small-cell carcinoma of the bronchus.
abstract: In small-cell carcinoma of the bronchus, extension to the brain is common. The role of prophylactic whole-brain irradiation and combination chemotherapy using CCNU in the prevention of brain extension is examined in the light of recent studies.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000517:prevention & control*; D001984:Bronchial Neoplasms / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000628:therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D008130:Lomustine / Q000627:therapeutic use; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009420:Nervous System / Q000528:radiation effects; D011832:Radiation Injuries / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D008130:Lomustine