Prolongation of islet allograft survival.
Pretreatment of donor rats with irradiation and silica followed by in vitro culture of the islets for 1 to 2 days prolonged survival of allografts across a minor histocompatibility barrier if "hand-picked," clean islets were used for transplantation. Pretreatment of donor rats with irradiation and silica in conjunction with a single injection of antilymphocyte serum (ALS) into the recipient produced a prolongation of survival of hand-picked islets transplanted across a major histocompatibility barrier.
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000628:therapy; D005260:Female; D006085:Graft Survival; D066298:In Vitro Techniques; D016381:Islets of Langerhans Transplantation; D008297:Male; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D051381:Rats; D012822:Silicon Dioxide / Q000627:therapeutic use; D013311:Streptozocin; D013997:Time Factors; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D013311:Streptozocin; D012822:Silicon Dioxide