Extemporaneous preparation of methyldopa in two syrup vehicles.
The stability of methyldopa in two extemporaneous syrup preparations was studied. Film-coated methyldopa tablets were triturated and incorporated into (1) unpreserved Syrup USP and (2) an equal mixture of simple syrup containing 0.5% citric acid and 0.2 N hydrochloric acid, in concentrations of 50 mg/ml. The preparations were stored in the dark, for 14 days at 5 C and 25 C. Samples were analyzed spectrophotometrically for methyldopa content at various intervals. Both preparations were stable under the conditions studied.
D001682:Biological Availability; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D008750:Methyldopa / Q000032:analysis; D010084:Oxidation-Reduction; D014677:Pharmaceutical Vehicles; D012995:Solubility; D013053:Spectrophotometry; D013997:Time Factors
D014677:Pharmaceutical Vehicles; D008750:Methyldopa