Evaluation of otic drops on infection and healing of traumatic tympanic membrane perforations.
Guinea pigs were used to compare the efficacy of three commercially available otic preparations in treating traumatic tympanic membrane perforations. The results suggest that a clear, viscous solution of low pH will significantly reduce the incidence of infection and will not retard subsequent membrane healing.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003091:Colistin / Q000627:therapeutic use; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000627:therapeutic use; D009355:Neomycin / Q000627:therapeutic use; D011113:Polymyxins / Q000627:therapeutic use; D012421:Rupture / Q000188:drug therapy*; D012996:Solutions; D014432:Tympanic Membrane; D014945:Wound Healing / Q000187:drug effects
D000900:Anti-Bacterial Agents; D011113:Polymyxins; D012996:Solutions; D009355:Neomycin; D006854:Hydrocortisone; D003091:Colistin