Clonal proliferation of lymphoid and myeloid progenitor cells in patients with hematological abnormalities.
Myeloid and lymphoid stem cell colony formation (GM-CFU) and L-CFU) was studied in patients with lymphoproliferative diseases, aplastic anemia and other hematological abnormalities. Most patients with acute lymphatic leukemia had low number of L-CFU with decreased or normal GM-CFU, while in Hodgkin's disease and chronic lymphatic leukemia L-CFU growth was very poor with only minor abnormalities of GM-CFU formation. Aplastic anemia was characterized by a decreased GM-CFU and normal L-CFU. Coculture studies suggested that a diminished colony formation may be linked to circulating lymphocytes that inhibit L-CFU as well as the reduction in number of precursor cells.
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D002455:Cell Division; D002648:Child; D002999:Clone Cells / Q000473:pathology; D003114:Colony-Forming Units Assay; D003586:Cytomegalovirus Infections / Q000097:blood; D006402:Hematologic Diseases / Q000097:blood*; D006410:Hematopoiesis; D006689:Hodgkin Disease / Q000097:blood; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood; D008214:Lymphocytes; D008232:Lymphoproliferative Disorders / Q000097:blood; D008875:Middle Aged