Establishment of a human oligodendroglial cell line.
A human oligodendroglial cell line has been established from a mixed glioma. Over a period of 22 months, the cell consisted of cells with the morphologic features of such a strong perinuclear halo, dichotomous branching, and a tendency to aggregate and float in the medium. In small aggregates, most cells are bipolar. The cell line also continues to synthetize the S-100 protein specific to neural tissue. The response of this cell line to dibutyryl-cyclic AMP is striking, resulting in a remarkable narrowing and elongation of the cell processes. This cell line could be used for studies on glial differentiation and neuron-glia interaction.
D003994:Bucladesine / Q000494:pharmacology; D002460:Cell Line; D005910:Glioma / Q000473:pathology*; D006801:Humans; D009457:Neuroglia; D009836:Oligodendroglia / Q000032:analysis / Q000166:cytology / Q000187:drug effects; D009418:S100 Proteins / Q000032:analysis
D009418:S100 Proteins; D003994:Bucladesine