title: Fate of ingested hepatitis B antigen in blood-sucking insects.
abstract: The fate of ingested hepatitis B antigen (HBsAg) in two mosquito species and two Hemiptera species was compared with the rate of blood meal digestion by these insects. In both mosquito species HBsAg was detected by radioimmunoassay for only a few hours after ingestion, disappearing well before the time of blood meal digestion. Production of a protease by the mosquito midgut may have been responsible for destruction of the antigen. In contrast, in the bedbug HBsAg remained detectable throughout a 5-week testing period. Moreover, titers rose during the last week, when blood meal digestion was complete, suggesting possible replication of the antigen. At no time was antigen detected in eggs or feces of any species tested, but juvenile bedbugs fed HBsAg when in the fourth or fifth instar stage still contained antigen after molting. These studies suggest that bedbugs may potentially be a more dangerous source of hepatitis B transmission than mosquitoes.
mesh_terms: D000818:Animals; D001511:Bedbugs / Q000276:immunology* / Q000378:metabolism; D009033:Culicidae / Q000276:immunology* / Q000378:metabolism; D006506:Hepatitis A / Q000635:transmission*; D006511:Hepatitis B Antigens / Q000378:metabolism*; D007303:Insect Vectors / Q000276:immunology
chemical_list: D006511:Hepatitis B Antigens