title: Cinnamic aldehyde in toothpaste. 1. Clinical aspects and patch tests.
abstract: Although cinnamon is known to cause dermatitis in bakers and confectioners, it has only rarely been reported as causing trouble in food or cosmetics. A newly-formulated 'spicy' toothpaste containing cinnamon as a flavouring agent was the cause of oral symptoms in eight patients referred to clinics in Buckinghamshire and in Malmö and in a further eight patients discovered subsequently. Similar symptoms and patch test results were observed independently at both centres. Positive reactions were obtained with 1% cinnamic aldehyde in 15 out of 16 patients tested. Only one patient reacted to a standard sample of balsam of Peru (25% in petrolatum).
mesh_terms: D000171:Acrolein / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000032:analysis; D000293:Adolescent; D000328:Adult; D002935:Cinnamomum zeylanicum / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D013280:Stomatitis / Q000139:chemically induced*; D014100:Toothpastes / Q000009:adverse effects* / Q000032:analysis
chemical_list: D014100:Toothpastes; D000171:Acrolein; C012843:cinnamaldehyde