Herpesvirus-induced availability of host DNA to exogenous endonuclease.
Deoxyribonuclease I penetrates herpesvirus-infected L cells and degrades host DNA without interfering with viral multiplication. The DNA of uninfected control monolayers of L cells, disrupted by scraping, is similarly attacked. In contrast, undisturbed L cells are not affected. This suggests that altered cell membrane permeability allows the nuclease to enter the cell, thereby permitting access of exogenous deoxyribonuclease to cellular DNA.
D000818:Animals; D002463:Cell Membrane Permeability; D004247:DNA / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism* / Q000494:pharmacology; D006564:Herpesviridae / Q000254:growth & development*; D004861:Herpesvirus 1, Equid / Q000254:growth & development*; D007739:L Cells / Q000378:metabolism*; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D014779:Virus Replication / Q000187:drug effects
D004247:DNA; D003851:Deoxyribonucleases