title: Lipid and lipopolysaccharide composition of Escherichia coli surface-altered mutants selected for resistance to levallorphan, tetracaine, and polymyxin.
abstract: Certain mutants of Escherichia coli with an altered permeability barrier have an essentially normal lipopolysaccharide, fatty acid, and phospholipid content, with a slight increase in the membrane protein:lipid ratio. The phospholipid metabolism of the lev and tec strains shows an abnormal response to growth in the selective agents levallorphan and tetracaine, respectively.
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D007977:Levallorphan / Q000494:pharmacology*; D050356:Lipid Metabolism; D008070:Lipopolysaccharides / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D009154:Mutation; D010743:Phospholipids / Q000378:metabolism; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D013748:Tetracaine / Q000494:pharmacology*
chemical_list: D008070:Lipopolysaccharides; D008563:Membrane Lipids; D010743:Phospholipids; D011113:Polymyxins; D013748:Tetracaine; D007977:Levallorphan; D011112:Polymyxin B