[Twin pregnancy following bromocriptine in an acromegalic patient staying sterile after removal of a pituitary adenoma. Immunocytochemical study of the tumor (author's transl)].
A pituitary adenoma was removed from a young woman who had acromegaly with galactorrhea-amenorrhea. Postoperatively, the dysmorphic acromegalic syndrome and galactorrhea decreased but amenorrhea, elevated serum GH and PRL concentrations remained. After Bromocriptine administration (5 mg daily) GH and PRL levels became normal, vaginal bleeding ensued within 3 months and a twin pregnancy was induced. An immunocytochemical study of the pituitary adenoma revealed the presence of two well defined, distinct cell types, each secreting one hormone with large preponderance of GH cells.
D000172:Acromegaly / Q000097:blood / Q000188:drug therapy*; D000239:Adenoma, Acidophil / Q000032:analysis / Q000503:physiopathology*; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006651:Histocytochemistry; D006801:Humans; D007158:Immunologic Techniques; D007247:Infertility, Female / Q000188:drug therapy*; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011388:Prolactin / Q000097:blood
D001971:Bromocriptine; D011388:Prolactin; D013006:Growth Hormone
Grossesse gemellaire après bromocriptine chez une acromégale restée stérile après exérèse d'un adénome hypophysaire. Etude de la tumeur en immunofluorescence.