Redox metabolism of glutathione in the red blood cell.
A theoretical study of the biochemical and clinical aspects of the reduction-oxidation metabolism of glutathione in the mature red blood cell is presented. A summarizing survey of the literature data has led to the formulation of a mathematical model which comprises the kinetic properties of the enzymes partaking in the hexose monophosphate pathway (HMP) and the oxidation of NADPH and GSH. The model takes the form of a system of differential equations describing the motion of metabolites in one cell. The interactions between metabolites ane enzymes, in particular between glutathione and the SH-dependent enzymes of glucose phosphorylation and HMP have been included into the model...
D004220:Disulfides / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood*; D005980:Glutathione Reductase / Q000097:blood; D006600:Hexosephosphates / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008956:Models, Chemical; D009249:NADP / Q000097:blood; D010084:Oxidation-Reduction; D010734:Phosphogluconate Dehydrogenase / Q000097:blood; D013438:Sulfhydryl Compounds / Q000097:blood
D004220:Disulfides; D006600:Hexosephosphates; D013438:Sulfhydryl Compounds; D009249:NADP; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D005978:Glutathione