title: Two qualitatively different effects of hyperthermia on acid phosphatase staining in mouse spleen, dependent on the severity of the treatment.
abstract: Heating the lower body of the mouse for up to 1.5 hours at temperatures above 41.0 degrees C causes an increase in splenic lysosomal acid phosphatase activity. For mouse temperatures up to 42.3 degrees C the change is probably due to enzyme activation, which reaches a maximum 1.5 hours after heating and then decays in a way which may be related to the transient ability of moderate hyperthermia to potentiate X-ray damage. At temperatures above about 42.5 degrees C hyperthermia results in a qualitatively different lysomal response, probably due to an increased lysosomal membrane permeability. The change is observed immediately after heating and remains high for at least 4 hours. The resultant release of hydrolases into the cytoplasm may be involved in the irreversible cell damage caused by severe hyperthermia.
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D004789:Enzyme Activation; D005260:Female; D006651:Histocytochemistry; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D008247:Lysosomes / Q000201:enzymology*; D051379:Mice; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology* / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D010744:Phosphoric Monoester Hydrolases