Dopamine-sensitive adenylate cyclase activity in the caudate nucleus and adrenal medulla in Parkinson's disease and in liver cirrhosis.
In human caudate nucleus and adrenal medulla dopamine-stimulated adenylate cyclase was measured. At a concentration of 100 microM dopamine, liver cirrhosis, carcinoma and therapy resistent parkinsonian patients showed decreased stimulation or even a reduction compared to controls. Therapy responding parkinsonian patients showed a decreased stimulation compared to controls, but this stimulation was significantly higher than in drug resistent patients.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000313:Adrenal Medulla / Q000201:enzymology*; D000368:Aged; D002277:Carcinoma / Q000201:enzymology; D002421:Caudate Nucleus / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000201:enzymology*; D008297:Male; D010300:Parkinson Disease / Q000201:enzymology*
D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D004298:Dopamine