Membrane mutations and production of enterotoxin B and alpha hemolysin in Staphylococcus aureus.
Staphylococcus aureus strain S-6, which produces enterotoxin type B (SEB), and strain 10-275, a high toxin-producing mutant derived from S-6, display pronounced differences in dye sensitivity, osmotic stability, and bacitracin sensitivity. Such characteristics are consistent with the concept that strain 10-275 is a membrane mutant of strain S-6. Some membrane mutants of S. aureus strain 14458 exhibit about two- to three-fold increases in SEB production whereas other membrane mutants show about twofold increases in alpha-hemolysin production. It is suggested that specific and independent membrane mutations control the secretory processes resulting in the extracellular elaboration of these exoproteins.
D000167:Acriflavine / Q000494:pharmacology; D001414:Bacitracin / Q000494:pharmacology; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D004768:Enterotoxins / Q000096:biosynthesis*; D004996:Ethidium / Q000494:pharmacology; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008248:Lysostaphin / Q000494:pharmacology; D009154:Mutation; D009995:Osmosis; D012965:Sodium Chloride; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013210:Staphylococcus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D004768:Enterotoxins; D006460:Hemolysin Proteins; D001414:Bacitracin; D000167:Acriflavine; D012967:Sodium Dodecyl Sulfate; D012965:Sodium Chloride; D008248:Lysostaphin; D004996:Ethidium