Action of dopamine on cyclic AMP-tissue level in the rat pancreas. Interaction with secretin.
Dopamine increased the cyclic AMP content of rat pancreas slices. It only partially displayed the agonist activity of secretin. Haloperidol 10(-4)M, a dopamine blocking agent almost completely inhibited the response to dopamine but had no effect on the response to secretin. Dopamine 10(-3)M, increased the cyclic AMP level induced by a low concentration of secretin and inhibited the production of cyclic AMP observed with a high concentration of secretin. Our data suggest that dopamine in the rat pancreatic tissue does not interfere with the secretin receptor but might act on the same adenylate cyclase.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012633:Secretin / Q000494:pharmacology*; D013997:Time Factors
D012633:Secretin; D000242:Cyclic AMP; D004298:Dopamine