Boric acid tolerant Vibrio cholerae: biological and physical properties.
Two boric acid tolerant variants were developed by passage in boric acid containing media from a mouse virulent parent Vibrio cholerae strain. The variants were stable, exhibited increased acid resistance, were less virulent to mice, but protected against challenge with the mouse virulent parent strain.
D000818:Animals; D001888:Boric Acids / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D000431:Ethanol / Q000494:pharmacology; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D014734:Vibrio cholerae / Q000187:drug effects*
D001888:Boric Acids; D010636:Phenols; D000431:Ethanol