Studies on the relationship between the equilibrium curve of oxyhemoglobin and 2,3-diphosphoglycerate in open-heart surgery.
The relationship between decreased oxygen affinity of hemoglobin and intraerythrocyte 2,3-diphosphoglycerate (2,3 DPG) concentration was confirmed and its existence during the period of open-heart surgery was demonstrated. It is suggested that the trauma sustained by the erythrocytes during their extracorporeal circulation is responsible, in large measure, for the decrease in 2,3 DPG concentration.
D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D002263:Carboxyhemoglobin / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis; D005112:Extracorporeal Circulation / Q000009:adverse effects; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins; D010313:Partial Pressure
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D002263:Carboxyhemoglobin; D010100:Oxygen