In vitro system for studying the efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus.
Antiviral antibody and interferon did not prevent in vitro reactivation of herpes simplex virus in latently infected sensory ganglia. Phosphonoacetic acid and 9-beta-d-arabinofuranosyladenine blocked reactivation, but this treatment did not eradicate the latent infection.
D000818:Animals; D000914:Antibodies, Viral; D000998:Antiviral Agents / Q000494:pharmacology*; D005260:Female; D005724:Ganglia / Q000382:microbiology; D006561:Herpes Simplex / Q000276:immunology / Q000382:microbiology; D007372:Interferons / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D010746:Phosphonoacetic Acid / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects*; D014740:Vidarabine / Q000494:pharmacology
D000914:Antibodies, Viral; D000998:Antiviral Agents; D007372:Interferons; D014740:Vidarabine; D010746:Phosphonoacetic Acid