Do methoxyflurane and enflurane induce hepatic drug-metabolizing enzymes?
The effect of acute anaesthetic (1,0 MAC) and chronic subanaesthetic (0,1 MAC) exposure to methoxyflurane and enflurane on the levels of several liver enzymes is reported. Methoxyflurane appears to be an enzyme-inducing agent similar to spironolactone, whereas enflurane does not appear to be an inducing agent for any of the enzymes studied.
D000818:Animals; D001580:Benzopyrenes / Q000032:analysis; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D003579:Cytochrome Reductases / Q000032:analysis; D003580:Cytochromes / Q000032:analysis; D004737:Enflurane / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000032:analysis; D005978:Glutathione / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000201:enzymology*; D008297:Male; D008733:Methoxyflurane / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology; D009575:Nitroanisole O-Demethylase / Q000032:analysis; D051381:Rats; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase
D001580:Benzopyrenes; D003580:Cytochromes; D008738:Methyl Ethers; D008733:Methoxyflurane; D003577:Cytochrome P-450 Enzyme System; D004737:Enflurane; D009575:Nitroanisole O-Demethylase; D003579:Cytochrome Reductases; D005982:Glutathione Transferase; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase; D005952:Glucose-6-Phosphatase; D005978:Glutathione