[Viral interaction with stimulated and nonstimulated human tonsil cells].
Interferon induction and the course of infection with paramyxovirus (Newcastle disease virus) and alphaviruses (Venezuelan equine encephalomyelitis, Sindbis, Semliki forest viruses) in human tonsillar cell cultures were studied in comparison with continuous Burkitt lymphoma, Raji, and Nawalva cells. The virus inducers stimulated production of dozens and hundreds IU50/ml of interferon in tonsillar cell cultures. No virus replication could be detected either in intact or phytohemagglutinin-stimulated tonsillar cells. Phytohemagglutinin treatment may lead to blocking of interferon production induced by Newcastle disease virus.
D002051:Burkitt Lymphoma / Q000382:microbiology; D002472:Cell Transformation, Viral; D004666:Encephalitis Virus, Venezuelan Equine / Q000472:pathogenicity; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis; D007700:Kinetics; D009522:Newcastle disease virus / Q000472:pathogenicity; D014066:Palatine Tonsil / Q000187:drug effects / Q000382:microbiology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012328:RNA Viruses / Q000472:pathogenicity*; D012845:Sindbis Virus / Q000472:pathogenicity; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000472:pathogenicity; D014776:Virus Cultivation
D010835:Phytohemagglutinins; D007372:Interferons
Vzaimodeĭstvie virusov so stimulirovannymi i nestimulirovannymi kletkami mindalin cheloveka.