Decrease of cyclic GMP in cerebellar cortex by intrastriatal (--)-sulpiride.
Intraperitoneal administration of (--)-sulpiride (12 to 50 mg/kg) produced a dose-related decrease in cGMP content in cerebellar cortex, while the (+)-sulpiride (10 microgram), but not after intracerebellar injection. These findings support the contention that (--)-sulpiride modifies cerebellar cGMP levels through and action on striatal dopamine receptors.
D000818:Animals; D002525:Cerebellar Cortex / Q000378:metabolism; D003342:Corpus Striatum; D006152:Cyclic GMP / Q000378:metabolism*; D003864:Depression, Chemical; D007267:Injections; D008297:Male; D051381:Rats; D013237:Stereoisomerism; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D013469:Sulpiride; D006152:Cyclic GMP