[Effect of acetazolamide on arterial blood lactate levels during recuperation in air from three days of hypercapnia].
After a three day-period of hypercapnia, carbonic anhydrase blockade by acetazolamide inhibits the development of arterial blood alcalosis during the return in normal environment, and thus eliminates the transient increase in lactacidemia due to glycolysis stimulation.
D000086:Acetazolamide / Q000494:pharmacology*; D000136:Acid-Base Equilibrium; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000097:blood* / Q000378:metabolism; D007773:Lactates / Q000097:blood*; D010100:Oxygen / Q000097:blood; D011188:Potassium / Q000097:blood; D011773:Pyruvates / Q000097:blood
D007773:Lactates; D011773:Pyruvates; D002245:Carbon Dioxide; D000086:Acetazolamide; D011188:Potassium; D010100:Oxygen
Effet de l'acétazolamide sur la concentration en lactate du sang artériel, au cours de la récupération en air après trois jours d'hypercapnie