title: Inhibition of the stimulatory effect of ACTH on adrenal and ovarian blood flow by indomethacin in the dog.
abstract: In anoestrous dogs heated thermocouples were inserted into one of the adrenals and ovaries. The basal adrenal and ovarian blood flow was recorded and enhanced by 1.2, 2.5 or 5.0 micrograms/kg of intravenous ACTH before and after the intravenous administration of 20 or 50 mg/kg of indomethacin. Indomethacin, depending on the dose and on the time elapsing after its administration inhibited the enhancing effect of ACTH on adrenal and ovarian blood flow. Since indomethacin is a specific inhibitor of prostaglandin synthesis it has been suggested that prostaglandins act as mediators in the vasodilatation elicited by ACTH in the canine adrenal and ovary.
mesh_terms: D000311:Adrenal Glands / Q000098:blood supply* / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D000818:Animals; D004285:Dogs; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D010053:Ovary / Q000098:blood supply* / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D000324:Adrenocorticotropic Hormone; D007213:Indomethacin