The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall.
Sixty-nine patients undergoing regional anaesthesia were premedicated with either lorazepam (1, 2, 3 or 5 mg), diazepam (5 or 10 mg), pentobarbitone (50 mg) or placebo given i.v., on a double-blind, randomized basis. A simple yet rigorous protocol was used to test the effect of these drugs on anterograde recall. Lorazepam 3 and 5 mg was found to affect anterograde recall significantly. None of the other drugs tested affected recall.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000494:pharmacology*; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D010424:Pentobarbital / Q000494:pharmacology*; D010919:Placebos; D011229:Preanesthetic Medication
D014151:Anti-Anxiety Agents; D010919:Placebos; D010424:Pentobarbital; D008140:Lorazepam; D003975:Diazepam