ACTH and vasopressin treatments immediately after a defeat increase future submissiveness in male mice.
Male mice were given a single injection of either adrenocorticotropic hormone (ACTH) or lysine vasopressin immediately after a defeat in an encounter with an aggressive male mouse. The defeated mice were tested for submissiveness at either 24 hours, 48 hours, or 7 days after the initial encounter. Both hormone treatments increased future submissiveness, although the time courses of the effects were different: The effects of ACTH disappeared after 48 hours, whereas those of vasopressin persisted for 7 days. These results suggest that changes in peptide hormone levels following naturally stressful experiences can affect the memory of those experiences, as expressed in future adaptive responses.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D008236:Lypressin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013315:Stress, Psychological / Q000503:physiopathology
D008236:Lypressin; D000324:Adrenocorticotropic Hormone