[Effect of carbostimulin and its mixture with vitamin D3 on the mineralization process of the bone callus in rabbits].
Mineralization of rabbit bone callus was studied within 15 days after resection of the upper part of radius bone inder conditions of treatment with carbostimuline and its mixture with vitamin D3. Content of calcium in the bone regenerate was increased by 40.8% after administration of carbostimuline and--by 70.5% after treatment with mixture containing vitamin D3. These preparations caused only slight effects on the phosphorus content. Dry residue in the regenerate os f animals, treated with the preparations, was increased approximately 2-fold (43% and 23%, respectively, p less than or equal to 0.001) as compared with control group. Content of citric acid was distinctly higher in the bone tissue of the treated animals. Within 15 days after the operation content of sialic acids wanormalized in blood serum of the animals. The data obtained were corroborated by X-ray and histologic examinations.
D000818:Animals; D002146:Bony Callus / Q000187:drug effects* / Q000378:metabolism; D002113:Calcification, Physiologic / Q000187:drug effects*; D002254:Carbonates / Q000627:therapeutic use*; D002413:Cations, Divalent / Q000627:therapeutic use; D002762:Cholecalciferol / Q000627:therapeutic use*; D002951:Citrates / Q000378:metabolism; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D008278:Magnesium Sulfate; D008297:Male; D017895:Manganese Compounds; D011817:Rabbits; D011885:Radius Fractures / Q000188:drug therapy / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects; D017967:Zinc Compounds
D002254:Carbonates; D002413:Cations, Divalent; D002951:Citrates; D004338:Drug Combinations; D017895:Manganese Compounds; D012794:Sialic Acids; D017967:Zinc Compounds; D002762:Cholecalciferol; C021160:Carbostimulin; D008278:Magnesium Sulfate
Vliianie karbostimulina i smesi ego s vitaminom D3 na protsess mineralizatsii kostnoĭ mozoli krolikov.