The influence of PGE1 and db-cAMP on permeability of lysosomal membranes of rat lymphocytes in the in vitro histamine test.
An attempt was made to develop as in vitro model of inflammation which would allow the study of the inflammatory process on the subcellular level and on the influence of PGE1 and db-cAMP on permeability of lysosomal membranes of liver lymphocytes. The results showed that the in vitro histamine test permits evaluation of early changes in the lysosomal membranes. Drugs such as acetylsalicylic acid, hydrocortisone, as well as PGE1 and db-cAMP exerted a stabilizing influence on the lysosomal membranes of rat lymphocytes.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects*; D010539:Permeability; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats
D011458:Prostaglandins E; D003994:Bucladesine; D006632:Histamine; D006854:Hydrocortisone