title: Luteinizing hormone-releasing factor-like immunoreactivity in islet cells and insulomas of the human pancreas.
abstract: Luteinizing hormone-releasing factor (LRF)-like immunoreactivity was demonstrated by a three-layer immunoperoxidase method in the islet cells of human pancreas and in the neoplastic cells of insulomas. Adenocarcinomas originating in the exocrine pancreas were LRF-negative. The results demonstrate another hypothalamic peptide-like material in the gastrointestinal tract, the biological role of which remains to be clarified.
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis* / Q000175:diagnosis; D007516:Adenoma, Islet Cell / Q000032:analysis* / Q000175:diagnosis; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000032:analysis* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000032:analysis* / Q000175:diagnosis
chemical_list: D007987:Gonadotropin-Releasing Hormone