Diazepam and meperidine on arterial blood gases in patients with chronic obstructive pulmonary disease.
Arterial blood gases were not significantly altered by 0.15 mg/kg intravenous dose of diazepam in patients with chronic obstructive lung disease. The PalphaO-2 was significantly reduced and the P-alphaCO-2 increased after administration of 1.5 mg/kg meperidine intravenously and the combination of 1.5 mg/kg meperidine with 0.15 mg/kg diazepam. Diazepam did not, however, significantly increase the ventilatory depression induced by meperidine. Therefore, 0.15 mg/kg diazepam intravenously causes no ventilatory depression by meperidine in patients with chronic obstructive lung diseases.
D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D002908:Chronic Disease; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D002245:Carbon Dioxide; D008614:Meperidine; D003975:Diazepam; D010100:Oxygen