title: An improved method for the determination of acetaldehyde in human blood with minimal ethanol interference.
abstract: A sensitive method for the determination of acetaldehyde in human blood is described which involves the derivatization of acetaldehyde with semicarbazide followed by head-space gas chromatographic analysis of acetaldehyde in plasma samples after acid hydrolysis of the semicarbazone derivative. Quantitative recovery of acetaldehyde from human blood was achieved and interference from ethanol, a major problem associated with earlier methods, was negligible.
mesh_terms: D000079:Acetaldehyde / Q000097:blood*; D002849:Chromatography, Gas; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010472:Perchlorates; D012664:Semicarbazones
chemical_list: D010472:Perchlorates; D012664:Semicarbazones; D000431:Ethanol; D000079:Acetaldehyde