[Effect of dichloroethane on the hydroxylating and conjugating activity of the membranes of the cytoplasmic network of liver tissue].
The hydroxylating and conjugating activities of the cytoplasmic network membranes in the rat liver tissues were studied as affected by dichloroethane. Administration of this substance decreases the monooxygenase and uridine diphosphate glucuronyl transferase activities in the tissue under study. The reduced content of cytochrome P450 is the earliest index of a decrease in the hydroxylating activity of the liver tissue. This fall in the hydroxylating and conjugating activity in the cytoplasmic network membranes of the liver tissues testifies to the fact that the intensity of the metabolism and detoxication of certain foreign substances in this organ under the effect of dichlorethane is reduced.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005025:Ethylene Dichlorides / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D006900:Hydroxylation; D007425:Intracellular Membranes / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D051381:Rats
D005025:Ethylene Dichlorides; D006843:Hydrocarbons, Chlorinated; D003577:Cytochrome P-450 Enzyme System; D009246:NADH Tetrazolium Reductase; D009251:NADPH-Ferrihemoprotein Reductase; D014453:Glucuronosyltransferase; D005952:Glucose-6-Phosphatase
Gidroksiliruiushchaia i kon''iugiruiushchaia aktivnosti membran tsitoplazmaticheskoĭ seti tkani pecheni pri deĭstvii dikhlorétana.