Morphometric method for evaluating the neurovirulence of live poliomyelitis vaccine.
A method for measuring morphological changes caused by residual neurovirulence in live poliomyelitis vaccine is described. The entire area of 16 standard parts of the central nervous system is measured directly under the microscope using a morphometric eyepiece grid. The method can be used to supplement the conventional system of scoring morphological lesions.
D000818:Animals; D001921:Brain / Q000473:pathology; D003588:Cytopathogenic Effect, Viral; D008253:Macaca mulatta; D017955:Poliovirus / Q000472:pathogenicity*; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D013116:Spinal Cord / Q000473:pathology; D014774:Virulence
D011054:Poliovirus Vaccine, Inactivated