title: [Dangerous side effects of lithium therapy].
abstract: A report is made on two cases of a pharmacogenic delirium as a result of combined lithium-haloperidol therapy, and on one case of lithium-induced diabetes insipidus renales with second-degree high pressure. Also, the development of a hydrocephalus internus male-resorptivus through lithium is discussed. In all patients there was a possible disposition due to old age or cerebral injury. Based on their effect on synaptic transmission the potentiating effect of lithium and haloperidol is discussed. Under the influence of Na-K stimulated ATPase and, thus, of active transport and adenylcyclase a basic mechanism of lithium therapy and its side-effects is seen.
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy*; D001714:Bipolar Disorder / Q000188:drug therapy; D001933:Brain Stem / Q000187:drug effects; D003693:Delirium / Q000139:chemically induced; D003919:Diabetes Insipidus / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D008094:Lithium; D006220:Haloperidol
vernacular_title: Bedrohliche Nebenwirkungen der Lithium-Therapie.