[Metabolic shifts in acute period of myocardial infarct and the possibility of their correction with curantil].
The effect of curantil on the values of energy metabolism in different parts of the myocardium was studied on dogs with experimental myocardial infarction. Tissue respiration, the activity of Krebs' cycle enzymes, cytochrome oxidase, pentose phosphate cycle and glycolysis, and the content of glycogen and adenyl components were studied. It was established that curantil has a positive effect on energy processes, particularly in myocardial areas not involved in ischemia. It is suggested that activation of tissue oxidation enzymes, which improves oxygen utilization and increases ATP production, is among the mechanisms of the curantil effect. It is noted that curantil stimulates the synthesis of glycogen and inhibits its decomposition. The accumulation in the myocardium of AMP, the precursor of adenosine possessing a marked coronarolytic effect, is an important aspect of the drug's action.
D000208:Acute Disease; D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects; D004176:Dipyridamole / Q000627:therapeutic use*; D004285:Dogs; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D006005:Phosphorylases / Q000378:metabolism
D000227:Adenine Nucleotides; D004176:Dipyridamole; D006003:Glycogen; D010088:Oxidoreductases; D003576:Electron Transport Complex IV; D006005:Phosphorylases
Metabolicheskie sdvigi v ostrom periode infarkta miokarda i vozmozhnosti ikh korrektsii s pomoshch'iu kurantila.