title: 9, 11-Azo-12-oxa-15-hydroxyprostanoic acid: a potent thromboxane synthetase inhibitor and a PGH2/TxA2 receptor antagonist.
abstract: 9,11-Azo-13-oxa-15-hydroxyprostanoic acid (AOHP) is shown to be a potent inhibitor of thromboxane synthetase with an IC50 at about 10(-6)M. It also blocked the agonist actions of 9,11-epoxymethano-PGH2 (IC50 9 x 10(-7) M) and TxA2 (IC50 2.4 x 10(-6) M) on human platelet-rich plasma indicating that it also is a PGH2/TxA2 receptor blocker.
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D006801:Humans; D008861:Microsomes / Q000187:drug effects; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects; D011450:Prostaglandin Endoperoxides, Synthetic / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D013552:Swine; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D013931:Thromboxanes / Q000037:antagonists & inhibitors*
chemical_list: C022281:9,11-azo-13-oxa-15-hydroxyprostanoic acid; D011450:Prostaglandin Endoperoxides, Synthetic; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D013931:Thromboxanes; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase; D001241:Aspirin