title: Assembly of viral structural proteins in cells infected with a temperature-sensitive mutant derived from an HVJ (Sendai virus) carrier culture. Brief report.
abstract: The processing of virus polypeptides synthesized in cells infected with HVJ (haemagglutinating virus of Japan--the Sendai strain of parainfluenza 1 virus) was studied. Maturation of a temperature-sensitive (ts) mutant (HVJ-pB) derived from an HVJ carrier culture was inhibited at 38 degrees C incubation. A considerable amount of viral components were made at the restrictive temperature. They were, with the exception of the polypeptide HN, well preserved without a great loss of their function and successfully incorporated into virus particles released after lowering the incubation temperature. The membrane (M) protein seems to be essential for virus morphogenesis.
mesh_terms: D000818:Animals; D002460:Cell Line; D000882:Haplorhini; D007668:Kidney; D009154:Mutation; D010222:Parainfluenza Virus 1, Human / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D010452:Peptide Biosynthesis; D013696:Temperature; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication
chemical_list: D014764:Viral Proteins