[Concomitant variations in the weight of adrenals and uremia during kidney provocation by high doses of glafenine].
High doses of glafenine given orally to rats induced renal tubular changes and simultaneously raised not only blood urea concentrations but also adrenal volume and weight. These modifications were transient and dose-dependent. Blood urea and adrenal weight returned to normal at the same time. Treated rats showed no alteration in serum K+, Na+, Cl-, uric acid, glucose and cholesterol and only a slight decrease in serum transaminase levels. An indirect relationship between renal lesions and adrenals hypertrophy induced by flafenine may exist.
D000311:Adrenal Glands / Q000187:drug effects*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005897:Glafenine / Q000494:pharmacology*; D006400:Hematocrit; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D013997:Time Factors; D014511:Uremia / Q000139:chemically induced*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D001786:Blood Glucose; D062367:ortho-Aminobenzoates; D005897:Glafenine; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Variations concomitantes du poids des surrénales et de l'urémie au cours de la néphrite provoquee chez le rat par de fortes doses de glafénine