Differentiation antigens on normal and Abelson virus transformed lymphocytes.
Rabbit antisera to Abelson leukemia virus (A-MuLV)-induced murine lymphomas have been analyzed by absorption with a variety of murine lymphoma lines. Antibody binding to a panel of cell lines and normal lymphocytes was visualized by using hapten-sandwich indirect membrane immunofluorescence. Novel membrane antigens thereby detected are shared between lymphosarcomas, B lymphomas, normal B lymphocytes, and normal membrane immunoglobulin negative (sIg-) bone marrow cells, but are not found on T cells, thymic lymphomas, plasmacytoid lymphomas, or myelomas. The existence of such shared differentiation antigens suggests that sIg- A-MuLV-induced lymphosarcomas may be transformed B cell precursors. Since differences in the expression of these antigens on individual plasma-cytoid lymphoma lines were found, this category of lymphomas may include cells at a variety of differentiation states.
D000483:Alleles; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D002454:Cell Differentiation; D003601:Cytotoxicity Tests, Immunologic; D007106:Immune Sera / Q000494:pharmacology; D007519:Isoantigens / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology*; D008223:Lymphoma / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007106:Immune Sera; D007519:Isoantigens