[Adrenergic and cholinergic mechanisms of the contractile reactions of major blood vessels].
Epinephrine, norepinephrine, and isoproterenol induced circular contraction of isolated segments of canine intracerebral internal carotid artery. The alpha--and beta-antagonists inhibited the effects of catecholamines. Acetylcholine showed dual effects involving both dilation (5.10(-12)--5.10(-9) g/ml) and contraction 5.10(-8) g/ml and higher). Atropine inhibited both effects. The K+ depolarization abolished the contractile effects of norepinephrine and acetylcholine. The blockade of calcium permeability by Mn++ abolished the contractile effects of sympathetic and parasympathetic mediators.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002339:Carotid Arteries / Q000294:innervation*; D002343:Carotid Artery, Internal; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D014661:Vasoconstriction; D014664:Vasodilation
D017981:Receptors, Neurotransmitter; D001285:Atropine; D011433:Propranolol; D007545:Isoproterenol; D000109:Acetylcholine; D002118:Calcium; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine
Adrenergicheskie i kholinergicheskie mekhanizmy sokratitel'nykh reaktsiĭ magistral'nykh mozgovykh sosudov.