title: The induction of dominant lethal mutations in Tilapia mossambica by alkane sulphonic esters.
abstract: A serial mating system has been used to enable study of the effect of chemical mutagens in Tilapia mossambica. Embryopathies incompatible with survival are attributed to dominant lethal mutations induced in developing male germ cells by methyl methanesulphonate and the isomeric forms of dimethyl-myleran.
mesh_terms: D000818:Animals; D002066:Busulfan / Q000494:pharmacology*; D005260:Female; D005399:Fishes / Q000235:genetics; D005799:Genes, Dominant; D005804:Genes, Lethal; D005821:Genetic Techniques; D008297:Male; D008698:Mesylates / Q000494:pharmacology*; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation; D013329:Structure-Activity Relationship
chemical_list: D008698:Mesylates; D009153:Mutagens; D008741:Methyl Methanesulfonate; D002066:Busulfan