Interaction of plasma membranes with influenza virus. V. Changes in creatine phosphokinase activity.
A decrease in creatine phosphokinase (CPK) activity was observed in plasma membranes (PM) treated with native A/WSN influenza virus but not in PM treated with heat-inactivated virus. The decrease in CPK activity depended on the amount of virus added to PM, on the pH of the medium and on the quality of the isolated PM. It was evident already after 10 minutes of incubation at 37 degrees C. The possible mechanism of the inhibition of the CPK activity and the relation to changes in adenosine triphosphatase (ATPase) activity and to fusion are discussed.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology* / Q000378:metabolism; D002463:Cell Membrane Permeability; D002642:Chick Embryo; D003402:Creatine Kinase / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009975:Orthomyxoviridae / Q000201:enzymology* / Q000378:metabolism
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D000251:Adenosine Triphosphatases