[Effect of steroid hormones on the rate of NADPH and NADH oxidation by rat liver microsomes].
Sex hormones heighten the rate of the NADP-H oxidation. A relation between the oxidation rate of steroids and the polarity of their molecule has been found. Both androgens and estogens inhibit the transport of electrons in the NAD-H-dependent chain. The capability of steroids to hydrooxylate depends upon the chemical structure and not the affiliation to androgens or estrogens.
D015113:Androstane-3,17-diol / Q000494:pharmacology; D000734:Androstenediols / Q000494:pharmacology; D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004970:Estrone / Q000031:analogs & derivatives / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D008968:Molecular Conformation; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology
D000734:Androstenediols; D012739:Gonadal Steroid Hormones; D009243:NAD; D015113:Androstane-3,17-diol; D004970:Estrone; D013739:Testosterone; D004997:Ethinyl Estradiol; D003687:Dehydroepiandrosterone; D004958:Estradiol; D009249:NADP; D004054:Diethylstilbestrol; D004964:Estriol
Vliianie steroidnykh gormonov na skorost' okisleniia NADF .H i NAD .H mikrosomani pecheni krys