[Hypercalcemia and osteoclast activating factor (OAF) associated with acute lymphoblastic leukemia (author's transl)].
The occurence of hypercalcemia appears to be unusual in leukemia. The mechanisms are numerous: secretion of PTH of PTH like substance, prostaglandin E2 or vitamin D like sterols. The reported case is one of lymphoblastic acute leukemia and hypercalcemia associated with osteoclast activating factor secreted by leukemic cells. In this patient the serum levels calcium closely paralleled the course of acute leukemia.
D000368:Aged; D000818:Animals; D001681:Biological Assay; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D007945:Leukemia, Lymphoid / Q000097:blood / Q000150:complications*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D010010:Osteoclasts
Hypercalcémie et facteur d'activation des ostéoclastes au cours d'une leucémie aiguë lymphoblastique.