Bilateral Wilms tumor presenting with acute renal failure and clinical findings mimicking cardiac failure.
A six-year-old girl presented with clinical signs and symptoms of right-sided heart failure. Cardiac catheterization demonstrated filling defects in both pulmonary arteries felt to represent metastatic lesions or thromboemboli. Intravenous pyelogram revealed bilateral renal masses and intrarenal obstruction. Acute renal failure was unresponsive to standard therapy. An open renal biopsy revealed Wilms tumor with favorable histology. Aggressive chemotherapy and irradiation were undertaken and renal function returned. This case adds to the heterogeneity of presentations described for Wilms tumor, and review of the literature reveals no other cases with similar presenting signs.
D058186:Acute Kidney Injury / Q000150:complications* / Q000628:therapy; D002648:Child; D005260:Female; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000628:therapy; D009396:Wilms Tumor / Q000150:complications* / Q000628:therapy