[Genetic determination of the response of the mouse hypothalamo-hypophyseo-adrenal system to cold and immobilization stress].
Peculiarities of the hypothalamo-pituitary-adrenal system (HPAS) reaction in mice of 8 inbred strains to a stress effect of the immoblization and of cold have been studied and a comparison of the effect with the reaction of the adrenal cortex to its direct stimulator--ACTH have been carried out. As a result of the study of the resting level of 11-hydroxycorticosteroids in peripheral plasma of inbred mice significant interstrain differences were found. A positive correlation between resting corticosteroids level and the reaction of HPAS to the stress in mouse strains under study was found, but none of them correlated with the reactivity of the adrenal cortex to ACTH.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000324:Adrenocorticotropic Hormone; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D012149:Restraint, Physical / Q000009:adverse effects*; D013045:Species Specificity; D013312:Stress, Physiological / Q000235:genetics* / Q000503:physiopathology
D015062:11-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone
Geneticheskaia determinirovannost' reaktsii gipotalamo-gipofizarno-nadpochechnikovoĭ sistemy mysheĭ na kholodovoĭ i immobilizatsionnyĭ stress.