title: [Effect of nucleophiles on the conversion of choline esters under the action of cholinesterase].
abstract: It is shown that effect of alcohols ROH on the hydrolysis of butyryl-choline and acetylcholine by choline esterase (E. C. 3.1.1.8) is complex; it included the concurrent and the unconcurrent inhibitions, the interaction with the acylenzyme to form more reactive triple complex, and the acyl migration. By titrometric method it is found that proportion of the transacylation and hydrolysis rates depends on hydrophobity of R only being independent on its electronegativity.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000215:Acylation; D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D002384:Catalysis; D002794:Choline / Q000031:analogs & derivatives / Q000378:metabolism*; D002802:Cholinesterases / Q000494:pharmacology*; D002918:Chymotrypsin / Q000494:pharmacology; D004952:Esters; D006736:Horses; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics
chemical_list: D000438:Alcohols; D004952:Esters; D002802:Cholinesterases; D002918:Chymotrypsin; D002794:Choline; D000109:Acetylcholine
vernacular_title: Vliianie nukleofilov na prevrashchenie kholinovykh éfirov pod deĭstviem kholinésterazy