Cytologic evaluation of experimental type 2 herpes simplex infection in mice.
The nature and frequency of cytopathologic changes in female mice genitally infected with type 2 herpes simplex virus have been investigated. The extent of virus infection in an individual mouse was assessed by a system of "plus scoring". Exfoliative cytology clearly provided a reliable evaluation of the extent of virus infection and a reliable prognostic index of mouse mortality. A composite index combining both cytologic and virologic information ('vircyt' value) was derived and shown to provide a convenient and precise prognostic index of mouse mortality.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D011379:Prognosis; D018139:Simplexvirus / Q000254:growth & development; D014626:Vaginal Smears; D014627:Vaginitis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*