title: Cell-mediated cytotoxicity against hamster cells transformed by avian sarcoma viruses. 2. Sensitivity of different subclones.
abstract: The presence of new antigens on different subclones of hamster cells transformed by avian sarcoma viruses was investigated by an in vitro cellular microcytotoxicity assay. The RS 2/3 and RS 2/10 subclones derived from the RS 2 clone, transformed with a Schmidt-Ruppin strain of RSV were highly sensitive to the cytotoxic action of spleen effector cells obtainled from hamsters immunized with RSV-transformed rat cells. The RS 2/6 subclone was sensitive only when 1,000 target cells were seeded and the RS 2/7 subclone was not susceptible to the cytotoxic action of effector cells. The RB 12/1 subclone, derived from the clone RB 12, transformed with a Bryan strain of RSV was poorly sensitive. The comparison between the sensitivity to XC-sensitized spleen cells of the different subclones and their other known properties was discussed.
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000302:isolation & purification; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D002460:Cell Line; D002999:Clone Cells; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D003602:Cytotoxicity, Immunologic; D007111:Immunity, Cellular; D008647:Mesocricetus; D051381:Rats; D001357:Sarcoma, Avian / Q000276:immunology*; D013154:Spleen / Q000166:cytology
chemical_list: D000951:Antigens, Neoplasm