Effects of prostaglandin E2 and dibutyryl cyclic AMP on the histamine-induced production of cortisol and corticosterone in isolated canine adrenal cells.
The steroidogenic effect of histamine in isolated adrenocortical cells of the dog was investigated in the presence of prostaglandin E2 (PGE2) and/or dibutyryl cyclic AMP (dbcAMP) in the medium. The effect of histamine, in combination with PGE2 was less than their total individual effects in the production of cortisol, but not ofcorticosterone. With dbcAMP the effect was just equal to them. However, the combination of histamine, PGE2 and dbcAMP showed an increase twice that of their total individual effects in the production of both steroids. These results indicate that, in the dog, histamine, PGE2 and dbcAMP may act synergistically in the adrenocortical cells.
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D003345:Corticosterone / Q000096:biosynthesis*; D004285:Dogs; D006632:Histamine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D003994:Bucladesine; D006632:Histamine; D003345:Corticosterone; D006854:Hydrocortisone