title: [Diseases caused by diisocyanates. 2. Diisocyanate asthma].
abstract: Diisocyanates are widely used as polymerizing agents in the production of polyurethanes. Exposure to high concentrations of toluene diisocyanate (TDI) causes the development of toxic-irritative symptoms in the respiratory tract. It has been observed that some workers, after repeated exposures and a latent period of months to years, develop asthmatic symptoms upon re-exposure to minute concentrations of diisocyanates. An immunological mechanism for this typical extrinsic asthma has not been adequately documented.
mesh_terms: D001249:Asthma / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D003485:Cyanates / Q000009:adverse effects*; D006801:Humans; D007105:Immune Complex Diseases; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000032:analysis; D009784:Occupational Diseases / Q000139:chemically induced*; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
chemical_list: D003485:Cyanates; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E
vernacular_title: Erkrankungen durch Diisocyanate. Teil 2: Das Diisocyanatasthma.