Production of vesicular stomatitis virus with low infectivity by interferon-treated cells.
In cultures of Ly cells treated with 10 or 30 reference units/ml of mouse interferon there was a 30 to 200 times reduction in the production of infectious vesicular stomatitis virus (VSV); virus particle production, as measured by VSV particle associated virus RNA, virus protein, and virus transcriptase, was inhibited by, at most, six times. These results suggested that interferon-treated cells produce VSV particles with low infectivity and resemble the findings in interferon-treated cells infected with murine leukaemia viruses.
D000818:Animals; D002460:Cell Line; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D012367:RNA, Viral / Q000096:biosynthesis; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D014764:Viral Proteins / Q000096:biosynthesis; D014774:Virulence; D014779:Virus Replication / Q000187:drug effects*
D012367:RNA, Viral; D014764:Viral Proteins; D007372:Interferons; D012321:DNA-Directed RNA Polymerases