Lithium: a modulator of cyclic AMP-dependent events in lymphocytes?
Theophylline, salbutamol, isoproterenol, and dibutyryl cyclic AMP inhibited E-rosette formation by human T lymphocytes and immunoglobulin M secretion from human plaque-forming B cells and augmented T-suppressor cell activity in three patients with agammaglobulinemia. Lithium chloride increased mitogen-induced lymphocyte proliferation and inhibited suppressor cell activity. In the presence of lithium, the effects of all the drugs except dibutyryl cyclic AMP could be prevented. The data suggest a role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes. Its potential role as an inhibitor of suppressor cell activity warrants further attention.
D000420:Albuterol / Q000037:antagonists & inhibitors; D000917:Antibody Formation / Q000187:drug effects*; D003994:Bucladesine / Q000037:antagonists & inhibitors; D000242:Cyclic AMP / Q000037:antagonists & inhibitors*; D006801:Humans; D007165:Immunosuppression Therapy; D008094:Lithium / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D010726:Phosphodiesterase Inhibitors / Q000037:antagonists & inhibitors; D010835:Phytohemagglutinins / Q000494:pharmacology; D012397:Rosette Formation; D013806:Theophylline / Q000037:antagonists & inhibitors
D010726:Phosphodiesterase Inhibitors; D010835:Phytohemagglutinins; D003994:Bucladesine; D008094:Lithium; D013806:Theophylline; D000242:Cyclic AMP; D000420:Albuterol