Relationship of human urinary and plasma kinins to sodium-retaining steroids and plasma renin activity.
In these studies we have shown that: 1. urinary kallikrein is an index of sodium-retaining steroid activity and may participate in the anti-natriuretic and kaliuretic effects of these hormones; 2. urinary kinin excretion is independent of changes in urinary kallikrein excretion; 3. levels of plasma bradykinin are highly correlated with levels of plasma renin activity probably because both respond to changes in extracellular fluid volume; and, 4. plasma bradykinin may act to antagonize angiotensin II to maintain normal blood pressure in hyper-reninemic states.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001477:Bartter Syndrome / Q000378:metabolism*; D001920:Bradykinin / Q000097:blood; D002648:Child; D005260:Female; D005438:Fludrocortisone; D006801:Humans; D006929:Hyperaldosteronism / Q000378:metabolism*; D007610:Kallikreins / Q000652:urine; D007705:Kinins / Q000378:metabolism*; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D011288:Prekallikrein / Q000097:blood; D012016:Reference Values; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine; D013256:Steroids / Q000378:metabolism*
D007705:Kinins; D013256:Steroids; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011288:Prekallikrein; D012964:Sodium; D007610:Kallikreins; D012083:Renin; D011188:Potassium; D001920:Bradykinin; D005438:Fludrocortisone