[Myxovirus structural investigations by spin probe methods. II. Influence of rimantadine on the structure of viral and artificial lipid membranes].
The lipid membrane structure of two myxoviruses (influenza and Sendai viruses), red blood cells and liposomes (prepared from total lipids of Sendai virus) have been investigated in the presence of rimantadine by means of two spin probes C5 and C6--the iminoxyl derivatives of stearic acids. Rimantadine was shown to penetrate the lipid membranes of myxoviruses and red blood sells and change the structure of the lipid phase no less than 0.8 nm apart from the viral surface. In the depth of 2.2 nm the structure of these lipid membranes remains unchanged after addition of rimantadine. Rimantadine also displaces the phase transition points of cell and viral lipid membranes to lower temperatures. Rimantadine does not change the lipid bilayer structure of liposomes 0.8 nm apart from its surface. These finding allow to suggest that rimantadine affects the cell and viral lipoprotein membranes.
D000218:Adamantane / Q000031:analogs & derivatives; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure*; D009980:Influenza A virus / Q000187:drug effects / Q000648:ultrastructure*; D008081:Liposomes; D008563:Membrane Lipids / Q000032:analysis; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects / Q000648:ultrastructure*; D012299:Rimantadine / Q000494:pharmacology; D013113:Spin Labels; D013696:Temperature
D008081:Liposomes; D008563:Membrane Lipids; D013113:Spin Labels; D012299:Rimantadine; D000218:Adamantane
Issledovanie struktury miksovirusov metodom spinovykh zondov. II. Vliianie rimantadina na strukturu virusnykh i iskusstvenno sformirovannykh lipidnykh membran.