title: Herpes simplex virus isolation from pyoderma gangrenosum lesions in a patient with chronic lymphatic leukemia.
abstract: Herpes simplex virus type 2 was isolated and identified from the vesicular border of pyoderma gangrenosum lesions on the genital region of a patient with chronic lymphatic leukemia. Dramatic relief of pain as well as quick disappearance of the vesicular margin of the lesions and of the inflammatory halo around them occurred as a result of local treatment with a solution of zinc acetate. A careful search for a viral agent should be done in every case of pyoderma gangrenosum occurring in a patient with a hematological malignancy or/and impaired immunity, especially if the lesions are on the face or in the genital region.
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000627:therapeutic use; D000287:Administration, Topical; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D011711:Pyoderma / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D018139:Simplexvirus / Q000302:isolation & purification*; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000085:Acetates; D015032:Zinc