[Corneal deposits in children on dialysis and treatment with vitamin D3 and 1,25 DHCC (author's transl)].
The corneas of 15 children on intermittent long-term dialysis for renal failure were studied, first during a period of treatment with high doses of vitamin D3 and subsequently during a study with the vitamin D metabolite 1,25 DHCC. Metastatic calcification of the limbus or increased limbic deposits only occurred during the second treatment phase, with vitamin 1,25 DHCC. In 5 of these children phases with plasma calcium levels were recorded which were closely related to the times when corneal changes occurred. In 3 children phosphate values were also increased. Only one child presented with normal calcium values and merely an increase in phosphate concentration. Regression of corneal deposits following normalization of calcium metabolism seems possible in the light of observations so far.
D000293:Adolescent; D002118:Calcium / Q000032:analysis*; D002648:Child; D002762:Cholecalciferol / Q000627:therapeutic use; D003315:Cornea / Q000473:pathology*; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D010710:Phosphates / Q000032:analysis; D006435:Renal Dialysis
D004100:Dihydroxycholecalciferols; D010710:Phosphates; D002762:Cholecalciferol; D002118:Calcium
Hornhautablagerungen beil Kindern mit Dialysebehandlung unter einer Therapie mit Vitamin D3 und 1,25-Dihydroxy-Cholecalciferol.