title: Renal prostaglandins: relationship to the development of blood pressure and concentrating capacity in pre-term and full term healthy infants.
abstract: The relationships between urinary prostaglandins (PGs)E2 and F2 alpha and the postnatal development of blood pressure and renal concentrating capacity were investigated in 14 pre-term and 32 full term healthy infants. Mean PGE2 and PGF2 alpha excretion was 18.9 and 10.1 ng/h/1.73 m2, respectively, in pre-term infant. In full term infants mean urinary PGE2 was significantly lower (13.4 ng/h/1.73 m2) and PGF2 alpha significantly higher (22.2 ng/h/1.73 m2). The decrease of the PGE2/PGF2 alpha ratio (P less than 0.001) was accompanied by an increase in blood pressure. High PGE2 levels in pre-term infants were inversely correlated with urinary cAMP excretion. A decreasing PGE2/PGF2 alpha ratio in full term infants was associated with increasing urinary osmolality. After intranasal administration of antidiuretic hormone (DDAVP) in 8 full term infants the increase in urinary osmolality and cAMP excretion was accompanied by a drop in PGE2 excretion to less than half the basal values. These findings suggests that the postnatal changes in urinary PG excretion are associated with a concomittant increase in blood pressure and in the concentrating capacity of the neonatal kidney.
mesh_terms: D001794:Blood Pressure; D000242:Cyclic AMP / Q000652:urine; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007671:Kidney Concentrating Ability; D011458:Prostaglandins E / Q000652:urine*; D011460:Prostaglandins F / Q000652:urine*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F; D000242:Cyclic AMP; D003894:Deamino Arginine Vasopressin