Comparative study of tumor-specific transplantation antigens of MC-29 chicken hepatoma and Rous sarcoma virus-induced sarcomas in mice.
Immunization of CBAT6T6 mice with MC-29 hepatoma antigen did not change the take of Rous sarcoma virus, Schmidt-Ruppin strain [RSV(SR)] mouse tumors after sc transplantation. Immunization with MC-29 hepatoma antigen only slightly increased the average survival time of the mice and significantly decreased tumor growth only at the minimal lethal dose level. Immunization of mice with MC-29 hepatoma antigen and immunization with chicken Rous sarcoma gave similar results; both elicited much less transplantation resistance than immunization with irradiated RSV(SR) mouse tumor cells. The data indicate that there are common tumor-specific transplantation antigens of MC-29 hepatoma and Rouse sarcoma, but further in vitro experiments are needed to prove this.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage; D000956:Antigens, Viral; D001354:Avian Leukosis Virus / Q000276:immunology; D002645:Chickens; D005260:Female; D006649:Histocompatibility Antigens / Q000008:administration & dosage; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D001357:Sarcoma, Avian / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D006649:Histocompatibility Antigens