Inhibition of the degradation of receptor-bound human choriogonadotropin by leupeptin.
The ability of leupeptin to block the degradation of receptor-bound human choriogonadotropin has been studied. It was found that this compound inhibited hormone degradation and intracellular cathepsin B activity in a parallel fasion, without affecting hormone-stimulated steroidogenesis.
D000818:Animals; D002403:Cathepsins / Q000037:antagonists & inhibitors; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D006801:Humans; D007976:Leupeptins / Q000494:pharmacology*; D007984:Leydig Cell Tumor / Q000378:metabolism; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013736:Testicular Neoplasms / Q000378:metabolism
D006063:Chorionic Gonadotropin; D007976:Leupeptins; D009842:Oligopeptides; D011956:Receptors, Cell Surface; D002403:Cathepsins