title: Antiviral activity of virus-like particles from Lentinus edodes (Shiitake). Brief report.
abstract: Interferon (IF) induction and antiviral activity by purified spherical (S) or filamentous (F) virus-like particles and S-derived RNA was studied. A single administration of S particles prior to virus challenge reduced significantly the mortality of mice infected with western equine encephalitis (WEE) virus.
mesh_terms: D000363:Agaricales; D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004667:Encephalitis Virus, Western Equine; D007372:Interferons / Q000096:biosynthesis; D008297:Male; D051379:Mice; D010942:Plant Viruses / Q000254:growth & development* / Q000648:ultrastructure; D012367:RNA, Viral / Q000032:analysis / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014762:Viral Interference
chemical_list: D012367:RNA, Viral; D007372:Interferons