title: The localization and distribution of gram-positive cocci in normal skin and in lesions of acne vulgaris.
abstract: The localization of gram-positive cocci in the normal skin and in the lesions of acne vulgaris was investigated using fluorescein-labeled antiserum raised to gram-positive, coagulase-negative cocci. The cocci were found in 10 of 19 specimens from normal facial skin and in 3 of 11 specimens from the normal skin of the rest of the body. The bacteria were found mostly in the openings of follicles, but in 6 of 10 facial skin specimens, they were also present deeply in the lumina of the dilated sebaceous follicles near the sebaceous glands. Cocci were found in 5 of 6 noninflammatory acne comedones. In inflammatory acne they were demonstrated not only in the follicular canals but also sparsely in the infiltrate surrounding the follicles.
mesh_terms: D000005:Abdomen / Q000382:microbiology; D000152:Acne Vulgaris / Q000382:microbiology*; D001132:Arm / Q000382:microbiology; D001415:Back / Q000382:microbiology; D001419:Bacteria / Q000302:isolation & purification; D001706:Biopsy; D002081:Buttocks / Q000382:microbiology; D003352:Corynebacterium; D004926:Escherichia coli / Q000302:isolation & purification; D005145:Face / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D006801:Humans; D008290:Malassezia / Q000302:isolation & purification; D008837:Micrococcus / Q000302:isolation & purification; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D012627:Sebaceous Glands / Q000382:microbiology; D012867:Skin / Q000382:microbiology*; D013210:Staphylococcus / Q000302:isolation & purification; D013909:Thorax / Q000382:microbiology