Polymorphism of B-tropic leukemia viruses from BALB/c mice: association of a p30 antigen with N- versus B-tropism.
Comparison of a number of murine leukemia virus clones by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed extensive protein polymorphism among B-tropic, but not N-tropic, isolates from BALB/c mice, particularly in migration of p30 proteins. A type-specific radioimmunoassay for p30 was developed which uniformly discriminated all B-tropic viruses from N-tropic viruses of BALB/c origin. N- and B-tropic viruses of C57BL/6 and AKR Fv-1b/b origin could also be distinguished by this assay.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D002460:Cell Line; D005347:Fibroblasts; D009052:Leukemia Virus, Murine / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology; D010641:Phenotype; D011110:Polymorphism, Genetic; D011863:Radioimmunoassay; D014764:Viral Proteins / Q000235:genetics*
D000956:Antigens, Viral; D014764:Viral Proteins