[Initial stages of the interaction of murine interferon with L929 cells].
After contact with mouse culture interferon in the cold, the resistance to viruses in L cells develops only after the cells are placed into a thermostate at 37 degrees C. The use of colcemide destroying microtubules prevents the development of this resistance at an early (actinomycin-sensitive) stage of interferon-cell interaction. In the actinomycin-resistant stage, however, colcemide practically exerts no influence on the interferon-induced resistance to viruses.
D000818:Animals; D002642:Chick Embryo; D003080:Cold Temperature; D003609:Dactinomycin / Q000494:pharmacology; D003703:Demecolcine / Q000494:pharmacology; D004686:Encephalomyocarditis virus; D007372:Interferons / Q000096:biosynthesis / Q000378:metabolism*; D007739:L Cells / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D009522:Newcastle disease virus; D011485:Protein Binding / Q000187:drug effects; D013696:Temperature; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus
D003609:Dactinomycin; D007372:Interferons; D003703:Demecolcine
Izuchenie nachal'nykh étapov vzaimodeĭstviia myshinogo interefona s kletkami L929.