Different behaviors of erythrocyte delta-aminolevulinic acid dehydratase. A comparison study between lead workers and normals.
Different characteristics of erythrocyte delta-aminolevulinic acid dehydratase (ALA-D1) between the workers with the history of occupational lead exposure and normals are described. In the blood of lead workers, when the hemolysates are heated at 60 C for five minutes, the activity of the erythrocytes ALA-D increases up to about 3.6-fold of an initial level, and as a result of heating the optimum in pH-activity curvee changes from pH 6.0 to pH 6.6, which is similar to the optimum pH of normal ALA-D. On the contrary, in normal blood, the optimum in the pH-activity curve is but little changed, even though the erythrocyte ALA-D activity is increased up to about 1.3-fold of the initial level by heating the hemolysates at 60 C for five minutes.
D000328:Adult; D004492:Edetic Acid / Q000008:administration & dosage; D004781:Environmental Exposure; D004912:Erythrocytes / Q000201:enzymology*; D006493:Heparin / Q000008:administration & dosage; D006358:Hot Temperature; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D007854:Lead; D008669:Metallurgy; D009787:Occupational Medicine; D000623:Porphobilinogen Synthase / Q000097:blood*; D011188:Potassium / Q000008:administration & dosage
D007854:Lead; D006493:Heparin; D004492:Edetic Acid; D006836:Hydro-Lyases; D000623:Porphobilinogen Synthase; D011188:Potassium