Oxisuran metabolism in the monkey.
Oxisuran metabolism was studied in the Rhesus monkey in order to assess the suitability of this species as an immunological model for man. The biotransformation pathways observed in the monkey are the same as those seen in rats and dogs. These pathways include the oxidation of oxisuran to a sulfone not found in human plasma or urine. Nevertheless, the monkey may merit immunological evaluation because the half-lives of biotransformation and elimination, although shorter than those exhibited by man, are greater than those in dogs and rats.
D000818:Animals; D001711:Biotransformation; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D007166:Immunosuppressive Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008253:Macaca mulatta; D008297:Male; D008954:Models, Biological; D010084:Oxidation-Reduction; D011725:Pyridines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013434:Sulfenic Acids / Q000097:blood / Q000378:metabolism / Q000652:urine; D013997:Time Factors
D002250:Carbon Radioisotopes; D007166:Immunosuppressive Agents; D011725:Pyridines; D013434:Sulfenic Acids