title: [Dose-effect of beta-sitosterin in type IIa and IIb hypercholesterolemias (author's transl)].
abstract: In a trial with 59 outpatients with hypercholesterolemia the effect of two different doses of 5.28 and 10,56 g Beta-Sitosterol was compared to placebo. Each treatment phase lasted six weeks. Serum cholesterol decreased on the average under Beta-Sitosterol by 10--13% (p less than 0.05) in correlation with LDL. The triglycerides were not affected; there was a slight increase in the HDL/LDL quotient. The optimal daily dose of Beta-Sitosterol was about 6 gm; the double dose was no more effective.
mesh_terms: D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008297:Male; D008875:Middle Aged; D012855:Sitosterols / Q000627:therapeutic use*; D014280:Triglycerides
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D012855:Sitosterols; D014280:Triglycerides
vernacular_title: Dosiswirksamkeit von ss-Sitosterin bei Hypercholesterinämien der Typen IIa und IIb.