Low molecular weight water-soluble peptidoglycans as adjuvants and immunostimulants.
The tetrasaccharide-heptapeptide (TH), when injected with mineral oil, exerted a strong adjuvant effect. It stimulated B and T cells, but did not increase the phagocytic activity of the reticulo-endothelial system. While BCG exerted significant preventive effect on the growth of sarcoma 180, leucosarcomatosis an EHRLICH ascitic tumor, TH, at the doses used, was devoid of such activity.
D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D001500:BCG Vaccine; D002286:Carcinoma, Ehrlich Tumor / Q000517:prevention & control; D006087:Graft vs Host Reaction; D007938:Leukemia / Q000517:prevention & control; D017710:Lymphocyte Transfusion; D008970:Molecular Weight; D009161:Mycobacterium / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology; D009368:Neoplasm Transplantation; D010457:Peptidoglycan / Q000276:immunology*; D010587:Phagocytosis; D012510:Sarcoma 180 / Q000517:prevention & control; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000276:Adjuvants, Immunologic; D000941:Antigens; D001500:BCG Vaccine; D010457:Peptidoglycan