Effect of infusion of pharmacologic amounts of vasopressin on renal electrolyte excretion.
Aqueous vasopressin was infused to bicarbonate- and glucose-loaded dogs and to nonloaded antidiuretic dogs in doses of 50 mU/kg per min or 50 mU/kg per h. Both doses caused a marked increase in sodium, chloride, and water excretion. The larger dose raised the fractional excretion (sodium clearance (C-Na)/glomerular filtration rate (GFR) times 100) of these ions from 2% or less to in excess of 20%. Blocking the pressor effects of these doses of vasopressin with sodium nitroprusside did not alter the marked natriuretic and chloriuretic effect.  The maximal rate of bicarbonate and glucose reabsorption was not depressed by vasopressin infusion; fractional phosphate excretion, however, was markedly increased. Inhibiting distal hydrogen ion secretion by inducing selective aldosterone deficiency failed to uncover a vasopressin-induced inhibition of proximal bicarbonate reabsorption that might have been masked by increased distal bicarbonate reabsorption. There was no significant change in GFR, renal plasma flow, or filtration fraction. The distribution of cortical renal blood flow (measured by the radioactive microsphere technique) shifted toward the inner cortex after vasopressin administration. Vasopressin, in pharmacologic doses, is a potent diuretic that most likely exerts this effect by directly inhibiting sodium reabsorption at a point in the nephron distal to the proximal tubule.
D000315:Adrenalectomy; D000450:Aldosterone; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002712:Chlorides / Q000652:urine*; D003900:Desoxycorticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005292:Ferricyanides / Q000494:pharmacology; D005919:Glomerular Filtration Rate; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D007672:Kidney Cortex / Q000098:blood supply; D008863:Microspheres; D009318:Natriuresis / Q000187:drug effects*; D009569:Nitric Oxide / Q000494:pharmacology; D012039:Regional Blood Flow; D013268:Stimulation, Chemical; D014667:Vasopressins / Q000494:pharmacology*
D001639:Bicarbonates; D002712:Chlorides; D005292:Ferricyanides; D014667:Vasopressins; D009569:Nitric Oxide; D003900:Desoxycorticosterone; D000450:Aldosterone; D003907:Dexamethasone; D005947:Glucose