A variant vascular endothelial cell line with altered growth characteristics.
A variant endothelial cell type was found to arise spontaneously from cultures of bovine aortal endothelial cells. This variant showed no contact inhibition and overgrew confluent cultures of wild-type endothelial cells. Unlike other reported variants of this cell type produced by chemical mutagenesis or by withdrawal of polypeptide growth factor, this variant retained the capacity to synthesis factor VIII antigen, but showed no alteration from wild-type in capacity to adsorb platelets. The variant also had an increased capacity to bind FITC-conjugated con A to its surface.
D000818:Animals; D000941:Antigens; D001011:Aorta / Q000166:cytology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D003260:Contact Inhibition; D004727:Endothelium / Q000166:cytology / Q000502:physiology; D005169:Factor VIII / Q000276:immunology; D008077:Lipoproteins, LDL / Q000378:metabolism; D011952:Receptors, Concanavalin A; D013936:Thymidine / Q000494:pharmacology
D000941:Antigens; D008077:Lipoproteins, LDL; D011952:Receptors, Concanavalin A; D005169:Factor VIII; D013936:Thymidine