title: Accumulation of 125I in the oocytes, thyroids, and plasma of laying Japanese quail treated with cyclic AMP, theophylline, or prostaglandins E1 or E2.
abstract: Dibutyryl cyclic AMP, theophyline, or prostaglandins E1 or E2 were injected intraperitoneally into laying Japanese quail in an attempt to stimulate increased transference of iodide by the ovarian membranes. Theophyline induced increased 18-hr 125I accumulations (by 7 to 18% of the injected dose) of borderline significance in the growing oocytes of some test groups. Theophyline plus DBcAMP treatment lead to a slight increase in 125I accumulation in the thyroid. Other treatments had no apparent effect on 125I transference. The prostaglandins induced oviposition within minutes of injection, as has been reported for uterine application of prostaglandins by other investigators. Means for plasma 125I levels for treated quail were 1.7 to 12.5 times greater than control levels. Values for oocyte to plasma and thyroid to plasma 125I ratios, it appeared that DBcAMP, theophyline, and the prostaglandins inhibited rather than stimulated the accumulation of 125I by the ovary and thyroid of the quail.
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D003370:Coturnix / Q000502:physiology*; D005260:Female; D007455:Iodine / Q000097:blood / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007700:Kinetics; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism*; D010063:Ovum / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D011784:Quail / Q000502:physiology*; D013806:Theophylline / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D011458:Prostaglandins E; D003994:Bucladesine; D007455:Iodine; D013806:Theophylline