Evidence for beneficial effect of intravenous glucose on the hemodynamic response to acute asphyxia.
Anesthetized rabbits were subjected to two 4-min periods of asphyxia with a 15-min recovery period intervening. During the recovery period animals received an iv infusion of either isotonic glucose or mannitol. Results indicated that glucose had a beneficial effect on systolic blood pressure during the second period of asphyxia. A direct metabolic action of glucose on the myocardium is favored as the explanation, but other possibilities include peripheral or neurohumoral effects.
D000208:Acute Disease; D000818:Animals; D001237:Asphyxia / Q000097:blood / Q000188:drug therapy*; D001769:Blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005947:Glucose / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral; D007552:Isotonic Solutions; D007773:Lactates / Q000097:blood; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D011817:Rabbits
D001786:Blood Glucose; D007552:Isotonic Solutions; D007773:Lactates; D002245:Carbon Dioxide; D008353:Mannitol; D005947:Glucose; D010100:Oxygen