title: Central nervous system effects of local anaesthetic agents.
abstract: A review is given of an experimental study on cats where the influence of acid-base changes on central nervous system toxicity of local anaesthetic agents was studied. The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase. Thus a respiratory acidosis increased this toxicity more if it was based on a metabolic acidosis than on a metabolic alkalosis (Englesson, 1974; Englesson and Grevsten, 1974). An extended analysis is presented where automatic frequency analysis was performed on the e.e.g. recordings performed during the i.v. infusion of lignocaine, bupivacaine, L 134, HS 37 and its optical isomers. The preliminary results show that the electrical changes appearing in the e.e.g. from the start of the i.v. infusion until seizure activity were the same if this time interval was as short as 1 min or as long as 8 min. It also revealed remarkable individual differences between agents, for instance lignocaine displaying marked electrical changes already in the first third of this time period where bupivacaine showed no changes until shortly before seizures.
mesh_terms: D000136:Acid-Base Equilibrium; D000142:Acidosis, Respiratory / Q000378:metabolism; D000498:Allyl Compounds / Q000633:toxicity; D000588:Amines / Q000633:toxicity; D000779:Anesthetics, Local / Q000633:toxicity*; D000813:Anilides / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002045:Bupivacaine / Q000633:toxicity; D002219:Carbamates / Q000633:toxicity; D002245:Carbon Dioxide / Q000097:blood; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D003201:Computers; D004569:Electroencephalography; D006863:Hydrogen-Ion Concentration; D008012:Lidocaine / Q000633:toxicity; D008619:Mepivacaine / Q000633:toxicity; D010313:Partial Pressure; D010880:Piperidines / Q000633:toxicity; D011318:Prilocaine / Q000633:toxicity; D011343:Procaine / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000498:Allyl Compounds; D000588:Amines; D000779:Anesthetics, Local; D000813:Anilides; D002219:Carbamates; D010880:Piperidines; D011318:Prilocaine; D002245:Carbon Dioxide; D011343:Procaine; D008012:Lidocaine; D008619:Mepivacaine; D002045:Bupivacaine