Inhibitory effects of gabexate mesilate (FOY) on experimental DIC.
The inhibitory effects of a newly synthesized protease inhibitor, Gabexate mesilate (FOY), on experimental disseminated intravascular coagulation were studied as compared with those of aprotinin or heparin. Thrombin, tissue thromboplastin, and endotoxin were used as DIC trigger substances. As parameters on DIC, platelet counts, white blood cell counts, neutrophilic leukocyte counts, fibrinogen, fibrin degradation products, platelet retention, platelet aggregation, prothrombin time, partial thromboplastin time were served. The drug efficacy in each parameter were expressed by the score system and analyzed statistically. The results were summarized as follows; (1) In thrombin-induced DIC, FOY was apparently superior to the other drugs (p less than 0.05). (2) In thromboplastin-induced DIC, heparin was slightly more effective than FOY or aprotinin. (3) In endotoxin infusion, there were no significant differences among them. In conclusion, the results of the present study suggest that FOY was more effective than heparin or aprotinin on experimental DIC.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy*; D004731:Endotoxins; D005340:Fibrinogen / Q000032:analysis; D006146:Guanidines / Q000627:therapeutic use*; D006493:Heparin / Q000494:pharmacology; D008297:Male; D008698:Mesylates / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D013917:Thrombin; D013925:Thromboplastin
D004731:Endotoxins; D006146:Guanidines; D008698:Mesylates; D011480:Protease Inhibitors; D005340:Fibrinogen; D006493:Heparin; D013925:Thromboplastin; D007611:Aprotinin; D013917:Thrombin