Differences in hepatic and metabolic changes after acute and chronic alcohol consumption.
Hepatic metabolism of ethanol to acetaldehyde by the alcohol dehydrogenase pathway is associated with the generation of reducing equivalents as NADH. Conversely, reducing equivalents are consumed when ethanol oxidation is catalyzed by the NADPH dependent microsomal ethanol oxidizing system. Since the major fraction of ethanol metabolism proceeds via alcohol dehydrogenase and since the oxidation of acetaldehyde also generates NADH, an excess of reducing equivalents is produced. This explains a variety of effects following acute ethanol administration, including hyperlactacidemia, hyperuricemia, enhanced lipogenesis and depressed lipid oxidation. To the extent that ethanol is oxidized by the alternate microsomal ethanol oxidizing system pathway, it slows the metabolism of other microsomal substrates. Following chronic ethanol consumption, adaptive microsomal changes prevail, which include enhanced ethanol and drug metabolism, and increased lipoprotein production. Severe hepatic lesions (alcoholic hepatitis and cirrhosis) develop after prolonged ethanol consumption in baboons. These injurious alterations are not prevented by nutritionally adequate diets and can therefore be ascribed to ethanol rather than to dietary inadequacy.
D000079:Acetaldehyde / Q000494:pharmacology; D000085:Acetates / Q000494:pharmacology; D000208:Acute Disease; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000437:Alcoholism / Q000150:complications / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002908:Chronic Disease; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D005234:Fatty Liver / Q000209:etiology; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D008954:Models, Biological; D009249:NADP / Q000378:metabolism; D051381:Rats
D000085:Acetates; D000431:Ethanol; D009249:NADP; D000429:Alcohol Oxidoreductases; D002374:Catalase; D000079:Acetaldehyde