Effect of certain inhibitors of glycoprotein synthesis on cell fusion induced by vesicular stomatitis virus.
The effect of certain metabolic inhibitors on the fusion of BHK-21 cells induced by vesicular stomatitis virus (VSV) was studied. The polykaryocyte formation in infected cells and virus growth were inhibited by 2-deoxy-D-glucose and D-glucosamine. Host-cell proteins synthesis was suppressed profoundly in both BHK-21-KB and B cells infected with VSV. On the other hand, glycoprotein synthesis was significantly enhanced during the polykaryocyte formation in BHK-21-KB cells, while it was suppressed in BHK-21-B cells which were not sensitive to cell fusion by VSV.
D000818:Animals; D002459:Cell Fusion / Q000187:drug effects*; D002460:Cell Line; D006224:Cricetinae; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005944:Glucosamine / Q000494:pharmacology*; D006023:Glycoproteins / Q000096:biosynthesis; D007668:Kidney; D008358:Mannose / Q000494:pharmacology; D014176:Protein Biosynthesis; D014721:Vesicular stomatitis Indiana virus / Q000502:physiology*
D003837:Deoxy Sugars; D006023:Glycoproteins; D003847:Deoxyglucose; D005944:Glucosamine; D008358:Mannose