Influence of plasma calcium and vitamin D on bone collagen. Effects on lysine hydroxylation and crosslink formation.
In chick bone collagen the degree of lysine hydroxylation and the magnitude of the crosslink ratio dihydroxylysinonorleucine/hydroxylysinonorleucine were both found to be inversely related to the concentration of plasma calcium. Lysine hydroxylation was also affected by a second factor related to vitamin D status.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D002645:Chickens / Q000378:metabolism; D002762:Cholecalciferol / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism*; D006901:Hydroxylysine / Q000378:metabolism*; D008297:Male; D014808:Vitamin D Deficiency / Q000097:blood / Q000517:prevention & control
D002762:Cholecalciferol; D006901:Hydroxylysine; D003094:Collagen; D002118:Calcium