Adrenocortical function in rats chronically exposed to high altitude.
In rats exposed to a simulated altitude of 5,486 m for 3 mo, pituitary and adrenal glands hypertrophied and plasma levels of corticosterone increased more than threefold over sea-level controls. The in vitro rates of corticosterone production by the quartered adrenal gland were significantly enhanced, but the responsiveness of the adrenal gland to ACTH remained normal.
D000064:Acclimatization; D000302:Adrenal Cortex / Q000502:physiology*; D000311:Adrenal Glands / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000531:Altitude; D000818:Animals; D003345:Corticosterone / Q000097:blood; D006984:Hypertrophy; D009929:Organ Size; D010902:Pituitary Gland / Q000473:pathology; D051381:Rats
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone