title: [Pharmacokinetics use in anti-cancer therapy (author's transl)].
abstract: Dynamic studies of anti-neoplasic agents provide a mathematical expression of various biological steps. High specific technics of dosage make possible the measurements of the drugs and their metabolites. Pharmacokinetics provides a new approach to three fundamental aspects in oncology: drug toxicity, relationship between drug schedule and response in each individual, drug resistance to anticancer drugs. Rational therapeutic approaches are made possible, as it was shown by the use of high dose of methotrexate.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008727:Methotrexate / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D008954:Models, Biological; D012516:Osteosarcoma / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate
vernacular_title: Application de la pharmacocinétique  à la stratégie thérapeutique anti-cancer.