title: Comparison of duration of immunity in chickens infected with a live infectious bronchitis vaccine by three different routes.
abstract: Three groups of chicks were vaccinated by aerosol, intra-ocular and drinking water routes with a live infectious bronchitis (IB) vaccine. At one, two, six, 15 and 32 weeks after vaccination five birds from each group were sampled for testing for IB haemagglutination-inhibiting (HI) antibodies and challenged. Assessment of susceptibility to infection was measured by recovery of virus from individual tracheas and from kidney and gonad pools four days after challenge. Virus was isolated from all kidney and gonad pools of birds challenged one week after vaccination, the kidney and gonad pools of the drinking water vaccinates at two weeks, the kidney pool of the intra-ocular group at 15 weeks and all organ pools except the gonads of the intra-ocular group at 32 weeks. Tracheal resistance was found in most of the birds challenged one week after vaccination and in all the birds tested at two weeks but had begun to wane by six weeks after vaccination. No correlation was found between low HI antibody titres of individual birds and their susceptibility to challenge measured by reisolation of virus from the traches, but birds with titres over log2 6 were always resistant.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002645:Chickens / Q000276:immunology*; D003332:Coronaviridae / Q000276:immunology*; D003333:Coronaviridae Infections / Q000517:prevention & control / Q000662:veterinary; D005123:Eye; D005260:Female; D006385:Hemagglutination Inhibition Tests; D007109:Immunity; D001351:Infectious bronchitis virus / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D011201:Poultry Diseases / Q000517:prevention & control; D013997:Time Factors; D014611:Vaccination / Q000379:methods / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D014765:Viral Vaccines