[Study of the somatotropic function of the pituitary gland and the glucocorticoid function of the adrenal glands in rats with alloxan diabetes].
The somatotropichormone (STH) content was studied in the hypophysis and the peripheral blood of rats with alloxan diabetes; the corticosterone content was determined in their peripheral blood. The STH content in the peripheral blood and the hypophysis of these rats failed to differ from that in the control group, but the blood STH content rose considerably in the sick animals. Exclusion of the insular apparatus function was accompanied by the adrenal gland hypertrophy, which correlated with the rise of the blood corticosterone level. The data obtained indicated that the insular apparatus insufficiency induced by alloxan was accompanied by changes in the somatotropic function of the hypophysis and of glucocorticoid function of the adrenal glands.
D000302:Adrenal Cortex / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D013006:Growth Hormone / Q000378:metabolism; D007328:Insulin / Q000172:deficiency; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D003345:Corticosterone
Issledovanie somatotropnoĭ funktsii gipofiza i gliukokortikoidnoĭ funktsii nadpochechnikov u krys s alloksanovym diabetom.