Specific adsorption of H-2-restricted cytotoxi T cells to macrophage monolayers.
These experiments tested whether Tc cells specific for foreign antigen (X) plus self H-2 adsorbed to macrophage monolayers displaying (a) X with allogeneic H-2; (B) self H-2 alone; (c) X plus self H-2. Specific adsorption occurred only in case (c), a result compatible with altered self and requiring further operational assumptions in dual recognition models.
D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D009980:Influenza A virus / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D006183:H-2 Antigens; D014301:Trinitrobenzenes