The use of indoramin to induce hypotension during general anaesthesia.
The alpha-blocker indoramin had only modest hypotensive action in the normotensive anaesthetised, paralysed patient undergoing major surgical intervention but had a greater effect in the hypertensive patient. The absence of deleterious cardiac effects even with intravenous doses as high as 1 mg/kg. supports previous findings as to the safety of this compound. It is possible that indoramin potentiates the hypotensive action of halothane but there is no evidence to suggest that an adverse interaction might arise when halothane is used to anaesthetise a patient receiving indoramin treatment.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001178:Arthroplasty; D001552:Benzazepines / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000150:complications; D007023:Hypotension, Controlled; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008408:Mastectomy; D008875:Middle Aged; D009392:Nephrectomy; D010880:Piperidines / Q000494:pharmacology*; D011292:Premedication; D011468:Prostatectomy; D013123:Spinal Fusion; D001743:Urinary Bladder / Q000601:surgery
D000317:Adrenergic alpha-Antagonists; D001552:Benzazepines; D007211:Indoles; D010880:Piperidines; D006221:Halothane