title: Effect of prostaglandins E1 and F2 alpha on neuromuscular transmission in the frog sartorius muscle.
abstract: End plate potentials (e.p.p.s.) and miniature end plate potentials (m.e.p.p.s.) were recorded intracellularly at the neuromuscular junction of the frog sartorius muscle. Addition of as little as 8.5 x10(-8)M PGE1 reduced the mean m.e.p.p. frequency. The mean amplitude of m.e.p.p.s was not changed, the mean amplitude of the e.p.p.s and the quantum content of the transmitter released by a nerve impulse was slightly reduced. A decrease in mean m.e.p.p. frequency was also seen in response to the administration of 8.5 x 10(-8)M PG2 alpha. The mean amplitude of e.p.p.s and m.e.p.p.s and the quantum content remained unchanged. The possible presynaptic mode of action of PGs in the preparation of discussed.
mesh_terms: D000818:Animals; D001001:Anura; D005071:Evoked Potentials; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011896:Rana temporaria; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F