title: [On the physiology and pharmacology of endorphins (author's transl)].
abstract: Endorphins are peptides with opiate-like action synthesized in various tissue, e.g. in intestine and central nervous system. Exact characterization of opioid-specific receptors and sensitive biological test assays for opioids were prerequisites for the discovery of these substances. Met- and leu-enkephalin were the first endorphins discovered. Both are pentapeptides. One of them, namely met-enkephalin (H-Tyr-Gly-Gyl-Phe-Met-OH) is likely to be a fragment of the peptides alpha- and beta-endorphin, both showing opioid-like actions, as well as of beta-lipotropin, a polypeptide showing no opioid-like activity: all these peptides include the pentapeptide met-enkephalin within their molecules. beta-liportropin and ACTH are likely to be fragments of a common precursor. At least both enkephalins (which are studied better as yet than the other endorphins) are supposed to be formed in the soma of the neuron and transported to the nerve ending, where they are released. They seem to have the function of neuromodulator or even of neurotransmitters. The pharmacological actions of endorphins resemble those of "classical opiates", both having e.g. analgesic effects. Both enkephalins are, among various other brain and spinal cord areas, localized in those areas which seem to be of particular relevance for perception and transmission of pain. They might, under certain conditions, play some part in the regulation of pain perception. Furthermore, they seem to be relevant for some neuroendocrine processes. Their relevance in symptoms of schizophrenic psychoses seems to be more doubtful. In opiate dependence no significant alterations of endorphin concentrations could be observed as yet.
mesh_terms: D000818:Animals; D004723:Endorphins / Q000502:physiology* / Q000627:therapeutic use; D004745:Enkephalins / Q000096:biosynthesis; D006801:Humans; D009431:Neural Conduction; D019965:Neurocognitive Disorders / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010146:Pain / Q000502:physiology; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology; D013312:Stress, Physiological / Q000378:metabolism; D019966:Substance-Related Disorders
chemical_list: D004723:Endorphins; D004745:Enkephalins; D011957:Receptors, Opioid
vernacular_title: Zur Physiologie und Pharmakologie von Endorphinen.