Enhancement of alcohol withdrawal seizures with 6-hydroxydopamine.
The relationship between central catecholamine neurons and alcohol withdrawal seizures was studied in rats pretreated with 6-hydroxydopamine to selectively destroy the central catecholamine nerve terminals. The alteration of alcohol withdrawal seizures was manifested by (1) a higher percentage of the rats developing the seizures, (2) an earlier onset of seizures, and (3) a greater severity of seizure activity. Seizure status was exhibited in 25% of the 6-hydroxydopamine-treated rats.
D000161:Acoustic Stimulation; D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D011292:Premedication; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D006892:Hydroxydopamines; D017981:Receptors, Neurotransmitter