title: The shark rectal gland: a model for the active transport of chloride.
abstract: The rectal gland of the spiny dogfish, Squalus acanthias, provides an easily studied model of active chloride transport powered indirectly by Na-K-ATPase. Co-transport of sodium with chloride can be demonstrated in membrane vesicles isolated from basolateral membranes of the gland. Chloride secretion is under the hormonal control of vasoactive intestinal peptide, and possibly other agents, via adenyl cyclase and cyclic AMP. A similar mechanism is probably responsible for the active transport of chloride across other biological membranes.
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D004284:Dogfish / Q000378:metabolism*; D008954:Models, Biological; D012491:Salt Gland / Q000378:metabolism*; D012754:Sharks / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000502:physiology; D014882:Water-Electrolyte Balance
chemical_list: D002712:Chlorides; D014660:Vasoactive Intestinal Peptide; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase