The antiglycolytic action on dental plaque of amine chlorides.
The influence on the glycolytic activity of dental plaque of different amine-hydrochloride compounds 300, 315 and 356 (oleylamine) respectively at concentrations equimolar to their corresponding amine fluorides 297, 242 and 335 at 250 ppm F-concentrations and of hexetidine and sodium laurylsulfate was tested in an in vivo/in vitro combination. Hexetidine and sodium laurylsulfate were assessed at concentrations equimolar to compound 315. After having refrained from oral hygiene for three days four test subjects rinsed for 3 minutes with 10 ml H2O. Plaque was collected from interdental areas immediately after the control water rinse and 6 and 60 minutes after rinsing for 3 minutes with 10 ml of test solution. The plaque then was exposed in vitro to 10% glucose solution, and pH-decreases due to glycolysis were recorded for 30 minutes. Rinsing with amine chlorides resulted in strong inhibition of glycolytic activity 6 minutes as well as 1 hour after rinsing. Hexetidine and sodium laurylsulfate did not depress the fermentation of glucose.
D000328:Adult; D000368:Aged; D000588:Amines / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology*; D003773:Dental Plaque / Q000187:drug effects / Q000378:metabolism*; D005459:Fluorides / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006590:Hexetidine / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D009067:Mouthwashes; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*
D000588:Amines; D002712:Chlorides; D009067:Mouthwashes; D012967:Sodium Dodecyl Sulfate; D006590:Hexetidine; D005947:Glucose; D005459:Fluorides