Fluidity and lipid composition of mouse biomembranes during adaptation to ethanol.
Showing that ethanol added in vitro increased the fluidity of mouse erythrocyte and synaptosomal membranes and that the same membranes isolated from mice after chronic treatment with ethanol had increased cholesterol and were resistant to ethanol in vitro, the study suggests that the animals had adapted to the chronic presence of the drug by changing their membrane lipid composition to offset the fluidizing effects of ethanol.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004361:Drug Tolerance; D004578:Electron Spin Resonance Spectroscopy; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D013574:Synaptosomes / Q000378:metabolism
D008563:Membrane Lipids; D000431:Ethanol; D002784:Cholesterol