title: [Effects of ampicillin and cefazolin combined with mecillinam (author's transl)].
abstract: Combination effects of mecillinam + ampicillin and mecillinam + cefazolin were investigated by the cross diffusion test and by the kinetics of bactericidal action. Synergism was found by cross diffusion in about 50% of strains of E. coli, Klebsiella and Proteus. Sensitivity against ampicillin was correlated with synergism. In mecillinam-resistant strains, synergism is usually absent. The combination of ampicillin or cefazolin with mecillinam leads to bactericidal acceleration; the effects are comparable to those of the combination with gentamycin. Mecillinam seems to be a clinically promising agent for combination chemotherapy. A simple test for synergism is desirable.
mesh_terms: D000560:Amdinocillin / Q000494:pharmacology*; D000667:Ampicillin / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology*; D003429:Cross Reactions / Q000187:drug effects; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects*; D007700:Kinetics; D007709:Klebsiella / Q000187:drug effects*; D010397:Penicillanic Acid / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects*
chemical_list: D000667:Ampicillin; D010397:Penicillanic Acid; D002437:Cefazolin; D000560:Amdinocillin
vernacular_title: Kombinationseffekte von Mecillinam mit Ampicillin bzw. Cefazolin.