Pharmacological properties of n1-piperonyl-n4-3,7,11-trimethyl-2,6,10-dodecatrienyl-piperazine, a new non-anticholinergic gastric antisecretory agent.
The special and general pharmacology of N1-piperonyl-N4-3,7,11-trimethyl-2,6,10-dodecatrienylpiperazine (U-27) is reported. According to the results of the animal experiments the compound turned out to be a well tolerated gastric antisecretory drug devoid of anticholinergic activity. The compound was able to prevent hypersecretion induced by pylorus ligature in rat and guinea pig. Its duration of action was remarkable and no tolerance occurred after a repeated treatment. The compound displayed also an interesting activity on several experimental ulcers.
D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors; D002490:Central Nervous System / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D006634:Histamine H1 Antagonists; D006863:Hydrogen-Ion Concentration; D008297:Male; D008688:Methacholine Compounds / Q000037:antagonists & inhibitors; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D010437:Peptic Ulcer / Q000188:drug therapy; D010879:Piperazines / Q000494:pharmacology* / Q000633:toxicity; D011090:Polyenes / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects
D005765:Gastrointestinal Agents; D006634:Histamine H1 Antagonists; D008688:Methacholine Compounds; D010879:Piperazines; D011090:Polyenes; D010095:Oxotremorine; D002217:Carbachol; D010418:Pentagastrin