[Factor XIII-heparin complex and its properties as a physiological solvent for unstabilized fibrin].
Some physiological properties of a complex of factor XIII with heparin were studied in relatively pure system in vitro. The complex was shown to exhibite the fibrinolytic activity toward unstabilized fibrin in the presence or absence of xi-aminocapronic acid, optimal pH for the activity was at pH 6.5--7.5 The activity was still observed after heating at 60 degrees C for 30 min. An excess of heparin was found to block the specific hydrolytic activity of the complex studied. The possibility of transition of heparin from a complex adrenaline-heparin to factor XIII with formation of factor XIII--heparin complex was shown. As a result of interaction of heparin with factor XIII the latter lost the fibrin-stabilizing activity.
D000614:Aminocaproates / Q000494:pharmacology; D001793:Blood Preservation; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D005176:Factor XIII / Q000037:antagonists & inhibitors / Q000502:physiology*; D005337:Fibrin / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D012996:Solutions; D013696:Temperature; D013997:Time Factors
D000614:Aminocaproates; D012996:Solutions; D005337:Fibrin; D006493:Heparin; D005176:Factor XIII; D004837:Epinephrine
Kompleks faktor XIII-geparin i ego svoĭstva kak fiziologicheskogo rastvoritelia nestabilizirovannogo fibrina