The role of the autonomic nervous system in the depression of parotid salivary secretion during hyperkalaemia in conscious sheep.
The rate of flow and electrolyte concentration of parotid saliva were measured before, during and after intravenous and contralateral intracarotid infusion of KCl (0.5 mol.1(-1)) and NaCl (0.5 mol.1(-1)) at 385-625 mumol. min(-1) for 40 min into 5 sheep. In intact conscious sheep contralateral intracarotid infusion of KCl caused marked depression of salivary secretion in all experiments whereas infusion of NaCl had no consistent effect on flow. Intravenous infusion of KCl into the intact conscious sheep caused a slight depression of salivary secretion but minimum flow was significantly higher than that during intracarotid infusion. When the sheep were anaesthetized salivary flow rates were low and contralateral intracarotid infusion of KCl either had no effect on flow or caused an increase in flow. After ipsilateral cervical sympathectomy contralateral intracarotid infusion of KCl into the conscious sheep caused a marked depression of salivary flow similar to that occurring when the sheep were intact. After section of the secretomotor nerve of the gland salivary flow rates were low and contralateral intracarotid infusion of KC1 had no effect on flow. The salivary flow responses of the sheep were consistent, regardless of whether the KCl infusions were given within 24 h or 1-2 weeks after cervical sympathectomy or secretomotor nerve section. Salivary sodium concentration was negatively correlated with salivary flow in all experiments. It was concluded that potassium acted at a site located in the head but by direct action on the salivary gland. The depression of salivary secretion by hyperkalaemia resulted from a decline in neural activity in the parasympathetic secretomotor innervation of the parotid gland.
D000768:Anesthesia, General; D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002415:Cats; D003714:Denervation; D004285:Dogs; D006400:Hematocrit; D006947:Hyperkalemia / Q000503:physiopathology*; D009994:Osmolar Concentration; D010306:Parotid Gland / Q000294:innervation / Q000378:metabolism*; D010424:Pentobarbital / Q000494:pharmacology; D011188:Potassium / Q000032:analysis; D012463:Saliva / Q000032:analysis; D012756:Sheep; D012964:Sodium / Q000032:analysis; D013562:Sympathectomy
D012964:Sodium; D010424:Pentobarbital; D011188:Potassium