[Experimental induced pancreatic carcinoma after choledochojejunostomy (author's transl)].
The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5--7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.
D000818:Animals; D001646:Bile / Q000502:physiology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced*; D002779:Cholestasis / Q000150:complications; D003135:Common Bile Duct / Q000601:surgery*; D006224:Cricetinae; D005260:Female; D007583:Jejunum / Q000601:surgery*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D010195:Pancreatitis / Q000209:etiology
D009602:Nitrosamines
Experimentell induziertes Pankreascarcinom nach Choledochojejunostomie.