title: Comparative pathogenicity of six avian adenovirus isolants in the liver.
abstract: The comparative pathogenicity of six avian adenovirus isolants for chickens was determined. The most virulent isolant was DPI-1, causing focal to massive hepatic necrosis with hemorrhage, while Tipton (Conn), Tipton (Purdue), GAL-1, and DPI-2 isolants were considered less pathogenic and produced only mild focal hepatic necrosis. The Indiana-C isolant was the least pathogenic and failed to produce any significant hepatic lesions. Intranuclear inclusions were observed in hepatocytes of all but the Indiana-C inoculated chickens on the third day postinoculation (PI), disappearing by the seventh day PI.
mesh_terms: D000257:Adenoviridae Infections / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D009336:Necrosis; D011201:Poultry Diseases / Q000209:etiology* / Q000473:pathology; D013997:Time Factors