Photosensitive epilepsy in Papio papio as a model for drug studies.
Photically-induced epilepsy in Papio papio provides a convenient model for assessing the efficacy and the acute neurological toxicity of new anticonvulsant drugs prior to clinical trial. Its drug sensitivity is broadly comparable to that of generalized seizures in man. It also shares some specific properties with syndromes of reflex epilepsy in man.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D000882:Haplorhini; D010215:Papio; D010672:Phenytoin / Q000627:therapeutic use; D010775:Photic Stimulation; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D001569:Benzodiazepines; D012701:Serotonin; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D010672:Phenytoin