Relationships between neural crest cells and catecholamine in suckling mice.
In suckling mice injected i.p. with a 27 mg/kg dose of L-hydrochloric acid isoproterenol, multiple neural crest tumors developed and cell death of neural crest cells occurred. It is speculated that neural crest derivatives may be beta-receptor cells and contain regulatory units of neurotransmission mediated through cyclic AMP.
D000818:Animals; D000833:Animals, Suckling; D002453:Cell Cycle / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009432:Neural Crest / Q000166:cytology / Q000187:drug effects*
D000242:Cyclic AMP; D007545:Isoproterenol