[Effect of chemical hepatic carcinogens and noradrenaline on the nucleoside phosphokinase activity of liver cells].
Distinct increase in activity of uridine kinase and pronounced decrease in thymidine kinase activity were observed in cell-free extracts of rat liver tissue at early stages of hepatocarcinogenesis caused by administration of N-nitrose diethylamine and 2-acetyl aminofluorene. Exogenous noradrepaline did not affect the altered activity of thymidine kinase but stimulated the effect of N-nitrose diethylamine and lowered the effect of 2-acetyl aminofluorene on the urindine kinase activity. Adrenergic neurotransmitters appear to influence the cell proliferation due to modification of the enzymes participating in the synthesis of nucleic acid precursors.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D002474:Cell-Free System / Q000187:drug effects; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008113:Liver Neoplasms / Q000201:enzymology*; D008297:Male; D009374:Neoplasms, Experimental / Q000201:enzymology; D009602:Nitrosamines / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D013937:Thymidine Kinase / Q000378:metabolism; D014541:Uridine Kinase / Q000378:metabolism
D009602:Nitrosamines; D004052:Diethylnitrosamine; D015073:2-Acetylaminofluorene; D010770:Phosphotransferases; D013937:Thymidine Kinase; D014541:Uridine Kinase; D009638:Norepinephrine
Vliianie khimicheskikh gepatokantserogenov i noradrenalina na aktivnost' nukleozidfosfokinaz kletok pecheni.