Decreased myocardial and renal content of 3',5'-AMP in genetically hypertensive rats: effects of PGE2 and PGF2 alpha.
Levels of c-AMP in heart and kidney of genetically hypertensive rats (SHR) were significantly lower than in normotensive Wistar animals. PGE2, 10 microgram/kg ip markedly increased the concentration of c-AMP in heart and kidney of SHR animals, but was without effect on this cyclic nucleotide content in normotensive controls. PGF2, in doses up to 100 microgram/kg, did not influence the concentrations of c-AMP in heart and kidney of SHR animals. Alterations in adenylate cyclase--c-AMP system in genetic hypertension are discussed.
D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis*; D006973:Hypertension / Q000378:metabolism*; D007668:Kidney / Q000032:analysis*; D008297:Male; D009206:Myocardium / Q000032:analysis*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats
D011458:Prostaglandins E; D011460:Prostaglandins F; D000242:Cyclic AMP; D000262:Adenylyl Cyclases