Cholinergic dysautonomia and Eaton-Lambert syndrome.
Cholinergic autonomic function was abnormal in a 47-year-old woman with Eaton-Lambert syndrome (ELS), not associated with carcinoma. Pupillary constriction to light and accommodation, sweating, lacrimation, and salivation were all affected. There was no evidence of Sjogren syndrome or botulinum intoxication. The defect of acetylcholine release from presynaptic terminals in the Eaton-Lambert syndrome may not be restricted to the neuromuscular junction of skeletal muscle.
D002799:Cholinergic Fibers / Q000503:physiopathology*; D003680:Deglutition Disorders / Q000503:physiopathology; D004402:Dysautonomia, Familial / Q000503:physiopathology*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009133:Muscular Atrophy / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009431:Neural Conduction; D010543:Peroneal Nerve / Q000503:physiopathology; D012021:Reflex, Abnormal / Q000503:physiopathology; D012025:Reflex, Pupillary; D013497:Sural Nerve / Q000503:physiopathology; D009435:Synaptic Transmission; D014459:Ulnar Nerve / Q000503:physiopathology; D014987:Xerostomia / Q000503:physiopathology