On the action of diethyldithiocarbamate as inhibitor of copper-zinc superoxide dismutase.
The rate constants of the reactions between pulse radiolytically produced superoxide radicals and the Cu(II) chelate of diethyldithiocarbamate were determined at pH 7.0. It was found that diethyldithiocarbamate forms a copper complex, which as no dismutating activity. The removal of the protein bound copper in superoxide dismutase by diethyldithiocarbamate yields the same effect as coordination of the copper in the enzyme.
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D007700:Kinetics; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides; D013859:Thiocarbamates / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
D013859:Thiocarbamates; D013481:Superoxides; D003300:Copper; D004050:Ditiocarb; D004492:Edetic Acid; D013482:Superoxide Dismutase; D015032:Zinc