Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.
A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006358:Hot Temperature; D007278:Injections, Spinal; D009068:Movement / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000008:administration & dosage / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
D005231:Fatty Acids, Unsaturated; D013373:Substance P; D002211:Capsaicin