[Effect of inhibitors of free radical processes on the "dark" paramagnetic centers of the melanoprotein granules of the pigment epithelium of the eye].
Effect of three inhibitors of free radical processes (IFRP) differing in antiradical activity (2-tret. butyl-6-methyl-3-oxipyridin, 2-ethyl-6-methyl-3-oxipyridin and 3-oxipyridin) on paramagnetic centres of melanoprotein granules of pigment epithelium was studied by ESR method at room temperature. It was shown that IFRP decreased the dark signal and that the reaction of paramagnetic particles dissociation proceeded according to the equation of the first order reaction. The rate constants of these reactions were calculated. It was found that the relative amount of reacting and non-reacting paramagnetic particles with the inhibitor depended on the nature and concentration of IFRP.
D000818:Animals; D001001:Anura; D055598:Chemical Phenomena; D002621:Chemistry; D003594:Cytoplasmic Granules; D003624:Darkness; D004578:Electron Spin Resonance Spectroscopy; D005136:Eye Proteins; D005609:Free Radicals; D066298:In Vitro Techniques; D008543:Melanins; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure*; D011725:Pyridines
D005136:Eye Proteins; D005609:Free Radicals; D008543:Melanins; D011725:Pyridines
Vliianie ingibitorov svobodnoradikal'nykh protsessov na "temnovye" paramagnitnye tsentry melanoproteinovykh granul pigmentnogo épiteliia glaza.