[Effect of administration of alpha-amanitine on Mn2+ - dependent poly-A-polymerase in rat liver nuclei].
Mn2+-dependent poly(A) polymerase activity tested in isolated rat liver nuclei is unchanged both in the absence and presence of exogenous poly(A) 30 min. after administration of a dose of alpha-amanitin that inhibits DNA-dependent RNA polymerase B. Longer times of treatment cause poly(A) polymerase to drop to 50% in the absence of poly(A) and to increase almost twice in its presence.
D000546:Amanitins / Q000494:pharmacology*; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008345:Manganese / Q000494:pharmacology; D009713:Nucleotidyltransferases / Q000378:metabolism*; D011062:Polynucleotide Adenylyltransferase / Q000378:metabolism*; D051381:Rats
D000546:Amanitins; D008345:Manganese; D009713:Nucleotidyltransferases; D011062:Polynucleotide Adenylyltransferase
Effeto della somministrazione di alfa-amanitina sulla poli(A) polimerasi Mn2+-dipendente di nuclei di fegato di ratto.