[The action of prostaglandin E2-induced pains on the metabolic and clotting systems of mother and child during birth (author's transl)].
11 pregnancies at term were terminated by dilatation of the uterine cervix, low amniotomy, and by intravenous administration of PGE2. The average infusion time was 4 hours 20 minutes, and the average total dose of PGE2 amounted to 0.2 mg. Parameters of acid-base changes, carbohydrate and energic state changes, gas metabolism, and changes in coagulation and fibrinolysis in mother and in fetus were analysed during labor and after birth. Labor activity and fetal cardiac action were monitored cardiotocographically. Checked against 50 uncomplicated spontaneous deliveries, we have found no disadvantageous changes in the parameters investigated.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007751:Labor, Induced; D007773:Lactates / Q000097:blood; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011247:Pregnancy; D011458:Prostaglandins E / Q000009:adverse effects / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D014469:Umbilical Arteries; D014471:Umbilical Veins; D014593:Uterine Inertia / Q000097:blood
D001786:Blood Glucose; D007773:Lactates; D011458:Prostaglandins E; D011773:Pyruvates; D002245:Carbon Dioxide; D000255:Adenosine Triphosphate; D010100:Oxygen
Die Einwirkung von Prostaglandin E2-induzierten Wehen auf das Stoffwechsel- und Gerinnungssystem von Mutter und Kind intra partum