Ontogeny of the induction of tyrosine hydroxylase by reserpine in the superior cervical ganglion, nucleus locus coeruleus and adrenal gland.
The ontogeny of the induction of tyrosine hydroxylase by reserpine has been studied in the superior cervical ganglion, adrenal gland and nucleus locus coeruleus of the rat. The inductive response developed gradually over a period of days in all 3 areas. However, the onset of induction occurred at markedly different times in these regions, being present from day 2 of life, the earilest time tested, in the adrenal, day 6 in the locus coeruleus and day 24 in the ganglion. In the ganglion even extremely high, toxic doses of reserpine failed to induce the enzyme during the first 3 weeks of life. Decentralization studies indicated that the ganglion was functionally innervated at this time. Moreover, the onset of induction was not time-locked to a specific phase of the postnatal development of tyrosine hydroxylase activity in the areas examined. It is probable that the development of inducibility reflects maturation of mechanisms intrinsic to the adrenergic cell, and this timetable is different for cells in different areas.
D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D004790:Enzyme Induction; D005725:Ganglia, Autonomic / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D012110:Reserpine; D014446:Tyrosine 3-Monooxygenase