Cholesterol synthesis by human fibroblasts in the presence of LDL and anti-LDL IgA.
LDL interact with fibroblasts through specific membrane sites. This reaction is the first step of a mechanism which leads to the regulation of intracellular cholesterol synthesis. When LDL form a complex with an IgA from a myeloma serum with mixed hyperlipidemia and xanthomatosis, they no longer function as a regulator, and the result is excess production of free intracellular cholesterol. No excess cholesterol production is observed when myeloma IgA is replaced by control IgG and IgA.
D002784:Cholesterol / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000276:immunology / Q000378:metabolism*; D009194:Myeloma Proteins / Q000378:metabolism
D007070:Immunoglobulin A; D008077:Lipoproteins, LDL; D009194:Myeloma Proteins; D002784:Cholesterol