Physico-chemical characteristics of interferons induced by human adenovirus in chick fibroblasts and leucocytes.
The physico-chemical characteristics of interferons with different anti-viral activities produced in chick fibroblast cells and leucocytes in response to the human adenovirus type 12 were investigated. The molecular weights of interferons produced by chick fibroblasts and leucocytes were similar: the main anti-viral activity was found at 27000 and 32000 and a low-titered shoulder at 28000 and 23000 respectively. Under our experimental conditions no oligomeric structure of interferons could be detected. The isoelectric pattern of leucocyte interferon was slightly different from that of the fibroblast interferon.
D000256:Adenoviridae / Q000254:growth & development*; D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology; D007525:Isoelectric Focusing; D007962:Leukocytes / Q000378:metabolism*; D008970:Molecular Weight
D007372:Interferons