title: Phase II to phase I conversion of Coxiella burneti in immunosuppressed mice.
abstract: Coxiella burneti strains 48 and Nine Mile, serologically in phase II, changed their antigenic properties and virulence for guinea pigs and mice upon passaging in immunosuppressed mice. Conversion to phase I of these strains in a system lacking antibody response throws doubt on the importance of specific antibodies in phase variation of C. burneti.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral; D002499:Centrifugation, Density Gradient; D003168:Complement Fixation Tests; D003381:Coxiella / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D007165:Immunosuppression Therapy; D051379:Mice; D013045:Species Specificity; D013154:Spleen / Q000382:microbiology; D014774:Virulence; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral