Selective labeling of apomorphine receptors by 3H-LSD.
There are at least two types of dopamine receptors: the 3H-dopamine or 3H-apomorphine receptor (with high or nM affinity for dopamine), and the 3H-neuroleptic receptor (with low or microM affinity for dopamine). While 3H-LSD can label the 3H-neuroleptic receptor, this study was done in order to label the 3H-apomorphine/dopamine receptor site. In the presence of excess phentolamine, serotonin and spiperone (to preclude binding to alpha-adrenergic, serotonergic and neuroleptic receptors, respectively) similar concentrations of dopaminergic drugs inhibited the binding (to calf caudate) of 3H-LSD and 3H-apomorphine. This is compatible with the concept that the 3H-apomorphine/dopamine receptor and the 3H-neuroleptic/dopamine receptor are separate.
D000818:Animals; D001058:Apomorphine / Q000378:metabolism*; D002417:Cattle; D002421:Caudate Nucleus / Q000378:metabolism; D008238:Lysergic Acid Diethylamide / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D013134:Spiperone / Q000494:pharmacology; D014316:Tritium
D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D014316:Tritium; D012701:Serotonin; D013134:Spiperone; D008238:Lysergic Acid Diethylamide; D001058:Apomorphine; D010646:Phentolamine