Neurofibrillary tangles induced by a sclerosing angioma.
A sclerosing angioma in the frontal cortex of a 40 year old woman produced local pressure, with resulting alteration of the blood-brain barrier. In the narrow cortical zone affected by chronic pressure, the level of aluminum was significantly elevated; and all neurons had neurofibrillary tangles of the Alzheimer type.
D000328:Adult; D000535:Aluminum / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009454:Neurofibrils / Q000032:analysis / Q000473:pathology*
D000535:Aluminum