Dependence of tyrosine and dopamine-beta-hydroxylases activities on disulfiram and diethyldithiocarbamate level in guinea pig brain and heart.
Tyrosine hydroxylase and dopamine-(DA)-beta-hydroxylase acitvities in guinea pig brain and heart were determined at various time after disulfiram (DS) and sodium diethyldithiocarbamate (DDC) injections. In the same tissues DS and DDC levels were measured. The linear relationship between the above enzymes activities and the levels of DDC in brain and heart has been found. The inactivation of the both enzymes is dependent on DDC content in tissues.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D004221:Disulfiram / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology*; D013859:Thiocarbamates / Q000494:pharmacology*; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*
D013859:Thiocarbamates; D004050:Ditiocarb; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D004221:Disulfiram