title: REM sleep and the prevention of endogenous depression.
abstract: The possibility of preventing endogenous depression may depend upon our understanding the brain mechanisms involved in the improvement of depression. Recent work in our laboratory has shed some light on these mechanisms. I will first describe this work and then suggest its possible preventive implications. Throughout this paper, the term depression means endogenous depression unless stated otherwise.
mesh_terms: D000328:Adult; D003863:Depression / Q000517:prevention & control* / Q000523:psychology; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008875:Middle Aged; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D007099:Imipramine