[Mechanisms of spontaneous hypoglycaemia in the adult (author's transl)].
Hypoglycaemia increases hepatic glucose output; insulin release is suppressed and the secretion of counter regulatory hormones enhanced. Catecholamines and glucagon seem to play a major role. The brain energy content is initially preserved, but the neuronal activity exhibits a 40-60 % decrease. Neither cerebral blood flow, nor oxygen consumption are altered. In addition to glucose, other substrates are metabolized. Cerebral edema may occur. An insulin-storage defect seems to be the main abnormality in insulinoma beta cell function. The most accurate biological tests are the insulin/glucose ratio, stimulation tests and suppression tests such as fasting and insulin-induced hypoglycaemia. Ectopic release of ACTH, HCG, HLP, glucagon or gastrin, is observed in some malignant insulinomas. When inconclusive, classic localising procedures may be effected by selective venous-blood sampling. Hypoglycaemia of extra-pancreatic tumors results from glucose hyperconsumption and decreases in glucose hepatic output, lipolysis and ketogenesis, related to secretion of insulin-like peptides NSILAs or NSILAp. Rare cases of hypoglycaemia related to insulin auto-antibodies of unknown origin have been reported. Alcoholic hypoglycemia results from diminished hepatic glycogen content, alcohol dehydrogenase pathway blockade, reduction of gluconeogenesis defect in the alcohol catabolic catalase pathway and enhancement of peripheral glucose consumption.
D007516:Adenoma, Islet Cell / Q000503:physiopathology; D000328:Adult; D000437:Alcoholism / Q000503:physiopathology; D001921:Brain / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism; D007330:Insulin Antibodies / Q000032:analysis; D000078790:Insulin Secretion; D008099:Liver / Q000378:metabolism; D009369:Neoplasms / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000503:physiopathology; D013002:Somatomedins
D005947:Glucose; D007328:Insulin; D007330:Insulin Antibodies; D013002:Somatomedins
Notions récentes sur les hypoglycémies spontanées de l'adulte.