Influence of alpha-MSH and ACTH on cortical bone remodelling in hypophysectomized rats.
Hypophysectomy increases both periosteal resorption and endosteal apposition along the femur diaphysis in rat. Administration of alpha-MSH decreased the periosteal resorption but had no effect on the endosteal apposition. ACTH had only minor effects on the endosteum. Thus, alpha-MSH and ACTH, in the doses used, have different effects on cortical bone in rat. The effect of alpha-MSH on cortical bone could be an effect of the hormone alone or by its stimulation of other factors.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001862:Bone Resorption / Q000187:drug effects; D005260:Female; D005269:Femur; D007016:Hypophysectomy; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D051381:Rats
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones