Intramuscular ACTH or placebo in the treatment of hyperemesis gravidarum.
Thirty-two women with hyperemesis gravidarum were treated with intramuscular ACTH (0.5 mg) or placebo for 4 days in a randomized double-blind trial. The two treatments were equally effective in relieving hyperemesis, although the function of the adrenal cortex was stimulated only during the ACTH therapy. The administration of ACTH thus appears useless for the treatment of severe vomiting in early pregnancy.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006939:Hyperemesis Gravidarum / Q000188:drug therapy*; D007273:Injections, Intramuscular; D010919:Placebos; D011247:Pregnancy; D011897:Random Allocation; D014839:Vomiting / Q000188:drug therapy
D010919:Placebos; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone