Dopaminergic mediation of the interoceptive cue produced by d-amphetamine in rats.
After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, significantly decreased amphetamine discrimination. Pretreatment with the dopamine-beta-hydroxylase inhibitor, disulfiram, or with the tryptophan hydroxylase inhibitor, p-chloro-phenylalanine, was observed to have no effect on the rats' ability to discriminate d-amphetamine. Administration of haloperidol, a selective dopamine receptor blocker, completely abolished the amphetamine discrimination, whereas alpha- and beta-adrenergic receptor blockade had no effect. Apomorphine, a dopamine receptor stimulant, produced amphetamine-like responses and this was, likewise, abolished by pretreatment with haloperidol. These data suggest that dopaminergic systems mediate the interoceptive cue produced by d-amphetamine in rats, and these results are discussed in relation to possible dopamine mediation of amphetamine psychosis and paranoid schizophrenia.
D000818:Animals; D001679:Biogenic Amines / Q000037:antagonists & inhibitors; D003463:Cues; D003913:Dextroamphetamine / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects; D004221:Disulfiram / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008781:Methyltyrosines / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D014365:Tryptophan Hydroxylase / Q000037:antagonists & inhibitors; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D001679:Biogenic Amines; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D011433:Propranolol; D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase; D004299:Dopamine beta-Hydroxylase; D006220:Haloperidol; D010134:Fenclonine; D004221:Disulfiram; D003913:Dextroamphetamine; D004298:Dopamine