On the narcotic cuing action of fentanyl and other narcotic analgesic drugs.
Using a food-reinforced two-levers operant procedure, rats could be trained to discriminate fentanyl (1.25 mg/kg, p.o., t-60') from solvent (1 ml/100 g B.W., p.o.,t60)treatment. The administration of the other narcotic analgesics bezitramide, dextromoramide, methadone and morphine produced a dose-related stimulus generalization with the standard fentanyl treatment. The results further evidence the validity of the narcotic cue.
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D003463:Cues; D004192:Discrimination, Psychological / Q000187:drug effects; D005283:Fentanyl / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats
D000701:Analgesics, Opioid; D009294:Narcotics; D005283:Fentanyl