Respiratory effects of lorazepam, pentobarbital, and pentazocine.
The respiratory effects of a new benzodiazepine, lorazepam, were compared to those of pentobarbital and pentazocine.  Pentobarbital, 50 and 150 mg, produced respiratory depression, as did pentazocine, 30 mg intramuscularly.  Lorazepam at 1.33 and 4 mg intramuscularly produced none.
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D010423:Pentazocine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D002245:Carbon Dioxide; D010424:Pentobarbital; D008140:Lorazepam; D010423:Pentazocine