The effect of N-(methoxy polyethylene glycol) rho-hydroxymercuribenzamide, a polymeric sulfhydryl group reagent, on spermatozoan motility.
The water-soluble, polymeric sulfhydryl group reagent N-(methoxypolyethylene glycol) rho-hydroxymercuribenzamide (Mw 5000) inhibited the motility of human spermatozoa. Its activity profile was very similar to that of rho-hydroxymercuribenzene sulfonate, a charged sulfhydryl group reagent that is a very poor membrane penetrant. These results suggest that functional sulfhydryl groups of the spermatozoan membrane are easily accessible and externally oriented on the membrane surface.
D002731:4-Chloromercuribenzenesulfonate / Q000494:pharmacology*; D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D008297:Male; D008623:Mercaptoethanol / Q000494:pharmacology; D008626:Mercuribenzoates / Q000494:pharmacology*; D010663:Phenylmercury Compounds / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013439:Sulfhydryl Reagents / Q000494:pharmacology*
D008626:Mercuribenzoates; D010663:Phenylmercury Compounds; D013439:Sulfhydryl Reagents; D011092:Polyethylene Glycols; D002731:4-Chloromercuribenzenesulfonate; D008623:Mercaptoethanol