Clinical trial with testosterone undecanoate for male fertility control.
The newly available orally effective testosterone undecanoate (TU) was investigated as a possible means for male fertility control. One of 7 normal volunteers exposed to 80 mg TU three times a day for 10-12 weeks became azoospermic, the remaining showed slightly suppressed or unaffected sperm counts. The insufficient suppression of spermatogenesis in 6 out of 7 subjects may be due to the fact that testosterone levels are only sufficiently high to suppress gonadotropins for some hours after ingestion of the drug.
D000284:Administration, Oral; D000328:Adult; D003864:Depression, Chemical; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000139:chemically induced; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013092:Spermatogenesis-Blocking Agents; D013094:Spermatozoa / Q000187:drug effects; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
D013092:Spermatogenesis-Blocking Agents; D013739:Testosterone; C010792:testosterone undecanoate