The partial adrenocortical hydroxylase deficiency syndrome in infertile women.
Eighteen infertile women desiring conception were selected for additional diagnostic studies on the basis of clinical evidence of hyperandrogenism characterized by acne and/or facial hirsutism. These 18 patients underwent stimulation tests with adrenocorticotropic hormone which demonstrated the presence of partial adrenocortical hydroxylase deficiences. All patients were then placed on glucocorticoid suppression therapy. Ten patients conceived and, of these, six required no therapy other than prednisone. Four conceived using a combination of prednisone and clomiphene therapy. Of othe eight patients who did not conceive, seven had other significant infertility factors. Therefore, of the patients without other significant fertility factors, 91% conceived. This study demonstrates that partial adrenocortical enzyme defects play a significant role in some women with clinical evidence of hyperandrogenism, and, in such women, either glococorticoid therapy alone or in combination with clomiphene is indicated.
D000293:Adolescent; D000302:Adrenal Cortex / Q000201:enzymology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000201:enzymology*; D011241:Prednisone / Q000627:therapeutic use; D013250:Steroid Hydroxylases / Q000172:deficiency*
D002996:Clomiphene; D000324:Adrenocorticotropic Hormone; D013250:Steroid Hydroxylases; D011241:Prednisone