title: [Design of inactivated polyvalent antiherpes vaccines].
abstract: The variants of inactivated vaccine against herpes simplex virus have been developed: 1, 2 and 1 + 2. The first two variants consist of 5 different strains of herpes virus of the appropriate type, and the third variant of their mixture. The strains differ in their antigenic and biological characteristics. Complete inactivation of the virus suspension was achieved by treatment of the vaccine with formalin. Herpes vaccines were used for immunization of 477 patients with frequently relapsing forms of herpes of different localizations. The therapeutic-prophylactic effect of these vaccines indicates their relatively high efficacy: by the end of 9 months favourable results exceeded 95%. Better results were obtained with HSV-1 vaccine. A second cycle of immunization given to some patients resulted in markedly positive effect.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004341:Drug Evaluation; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D007114:Immunization; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D018139:Simplexvirus / Q000276:immunology*; D013937:Thymidine Kinase / Q000032:analysis; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D014776:Virus Cultivation
chemical_list: D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D013937:Thymidine Kinase
vernacular_title: Konstruirovanie inaktivirovannykh polivalentnykh protivogerpeticheskikh vaktsin.