[Action of luliberine on the Na,K-ATPase and Ca-ATPase activity of the sarcolemma of the rat heart].
The effect of luliberine, one of the hypothalamic releasing-factors, upon the ATPase activity in the rat heart sarcolemma was investigated. A decrease in the (Na+-K+)-ATPase activity and stimulation of Ca-ATPase activity under the influence of luliberine were demonstrated. Inhibition of (Na+-K+)-ATPase by cAMP and noradrenaline was also revealed. A possibility of the direct and cAMP-mediated action of luliberine on the Na+-K+)-ATPase activity is suggested.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007031:Hypothalamus; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012508:Sarcolemma / Q000187:drug effects* / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D007987:Gonadotropin-Releasing Hormone; D000242:Cyclic AMP; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine
Deĭstvie liuliberina na aktivnost' Na,K-ATFazy i Ca-ATFazy sarkolemy serdtsa krysy.