Selective immunodeficiency and malignant lymphoma of the central nervous system. Possible relationship to the Epstein-Barr virus.
This report presents the findings of a study of a 17-year-old male with a selective immunodeficiency to the Epstein-Barr virus, who died of a malignant lymphoma following clinical infectious mononucleosis. Autopsy findings and immunohistochemical techniques demonstrated a malignant lymphoma with B-lymphocyte characteristics which primarily involved the central nervous system (CNS). The relationship of the Epstein-Barr virus to lymphoproliferation is discussed.
D000293:Adolescent; D000914:Antibodies, Viral; D001402:B-Lymphocytes; D002493:Central Nervous System Diseases / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007244:Infectious Mononucleosis / Q000150:complications*; D008223:Lymphoma / Q000150:complications*; D008297:Male
D000914:Antibodies, Viral