Determination of isonicotinic acid hydrazide in serum.
A method for the determination of isonicotinic acid hydrazide is given. The hydrazide is complexed with cupric ions and condensated with an aromatic aldehyde substituted in ortho-position with a hydroxyl group. The method is adapted to the AutoAnalyzer equipment of first and second generation. Pilot measurements on the pharmacokinetic behaviour of isonicotinic acid hydrazide are presented.
D000368:Aged; D001322:Autoanalysis / Q000295:instrumentation / Q000379:methods; D002614:Chelating Agents; D003300:Copper; D006207:Half-Life; D006801:Humans; D006834:Hydrazines; D006863:Hydrogen-Ion Concentration; D007538:Isoniazid / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D002614:Chelating Agents; D006834:Hydrazines; D003300:Copper; D007538:Isoniazid