title: Hypersomnolent and nonhypersomnolent patients with upper airway obstruction during sleep.
abstract: When the syndrome consisting of sleep-induced apnea and hypersomnolence is due to upper airway obstruction, the hypersomnolence is believed to be the direct result of deprivation of sleep related to such obstructions. The purpose of this report is to describe a group of four asymptomatic subjects with upper airway obstruction during sleep. These subjects were matched with a group of patients with the syndrome of sleep-induced apnea and hypersomnolence. There were no significant differences between symptomatic and asymptomatic groups in terms of the absolute number of upper airway obstructions (252 vs 231), their mean duration (20.8 vs 25.9 seconds), the mean arterial carbon dioxide tension during sleep (39 vs 39 mm Hg), or the electroencephalographic patterns during sleep. The only variables that emerged as significantly different between the two groups were the weights (128 vs 90 kg; P less than 0.05), the low arterial oxygen pressure (PaO2) on waking (54 vs 80 mm Hg; P less than 0.002), and the lower PaO2 during sleep (47 vs 70 mm Hg; P less than 0.01) in the symptomatic patients. From these data, we conclude that the hypersomnolence in patients with sleep-induced apnea due to upper airway obstruction cannot be explained by deprivation of sleep, and other factors need to be carefully examined in future studies.
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000097:blood / Q000150:complications*; D001049:Apnea / Q000097:blood / Q000209:etiology*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D006970:Disorders of Excessive Somnolence / Q000097:blood / Q000209:etiology*; D004569:Electroencephalography; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010101:Oxygen Consumption; D012890:Sleep; D012892:Sleep Deprivation; D012893:Sleep Wake Disorders / Q000209:etiology*; D012895:Sleep, REM; D012907:Smoking / Q000150:complications; D013577:Syndrome
chemical_list: D002245:Carbon Dioxide