Effects of dihydroergotoxine (Redergine) on the sleep-wakefulness cycle in the cat.
Investigations with dihydroergotoxine (DHE 1.0; 3.0 and 5.0 mg/kg i.p.) indicate that DHE exerts effect on the sleep-wakefulness cycle of the cat. In doses of 3.0 and 5.0 mg/kg i.p. DHE has a suppressant effect on sleep, and in particular on REM sleep, while wakefulness was increased. With a dose of 1.0 mg/kg, wakefulness and REM sleep were decreased, while slow-wave sleep was increased.
D000375:Aging; D000818:Animals; D002415:Cats; D004088:Dihydroergotoxine / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D004088:Dihydroergotoxine