Gluconeogenic key enzymes in normal and intrauterine growth-retarded newborn rats.
Intrauterine growth retardation was induced in rats by ligation of the artery of one of both uterine horns. Activities of pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6-diphosphatase and glucose-6-phosphatase in liver were measured at 0, 1, 3 and 6 h after delivery in newborn rats from normal and sham-operated litters, and from ligated and contralateral uterine horns. Lower activities of fructose-1,6-diphosphatase were found in small-for-gestational-age animals in comparison with animals from contralateral horns. When small-for-gestational-age animals were compared with animals from sham litters (which could be regarded as more satisfactory controls), the activities of two other gluconeogenic enzymes (pyruvate carboxylase and glucose-6-phosphatase) appeared to be lower as well. It is concluded that a delay in the development of these gluconeogenic enzymes could play a role in neonatal hypoglycemia in small-for-gestational-age rats.
D000818:Animals; D001158:Arteries / Q000601:surgery; D005260:Female; D005317:Fetal Growth Retardation / Q000201:enzymology*; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005943:Gluconeogenesis; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D007003:Hypoglycemia / Q000378:metabolism; D008026:Ligation; D008099:Liver / Q000201:enzymology; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism*; D011247:Pregnancy; D011766:Pyruvate Carboxylase / Q000378:metabolism*; D051381:Rats; D014599:Uterus / Q000098:blood supply
D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D011766:Pyruvate Carboxylase