Effect of sodium loading and ACTH on blood pressure of sheep with reduced renal mass.
Sodium chloride loading produced a rise in blood pressure in intact sheep which was potentiated by reduction in renal mass. ACTH induced hypertension was also potentiated by reduced renal mass, suggesting a volume component for the hypertension when renal excretory capacity for salt and water is reduced.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007668:Kidney / Q000502:physiology*; D009392:Nephrectomy; D011188:Potassium / Q000097:blood; D012756:Sheep; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D011188:Potassium