Corticotroph cells of the human pituitary in old age.
This study was undertaken, utilizing immunocytologic methods and in particular the immunoperoxidase technique, to evaluate corticotroph cell morphology and distribution in the pituitary glands of aged subjects dying of various diseases. Early histologic studies did not allow for reliable identification of the different adenohypophysial cell types. Corticotroph cell distribution within the gland is described as well as its morphological characteristics. Our findings substantiate conclusions based on biochemical investigations that corticotroph cells remain unchanged and function normally in aged subjects.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000375:Aging; D001491:Basophils; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000166:cytology* / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000378:metabolism
D000324:Adrenocorticotropic Hormone