title: [Does the concept for the prevention of chronic ischemic heart disease correspond to current ideas on etiology and pathogenesis of arteriosclerosis?].
abstract: A summarizing description of the essential relations between the existence of risk factors and the course of the morphologic changes in the arteriosclerosis in the intima is given. In this process the low density lipoproteins play an important role which together with further etiologic factors contribute to an increased permeability of the endothelium and to the stimulation of the proliferation and modulation of the smooth muscle cells, which are of central importance in the vascular reaction. Certain effects on the progression of the arteriosclerosis as well as a regression of adequate morphologic changes are to be expected from an elimination of risk factors, provided the necessary measures begin in the early stages of the arteriosclerosis, i. e. in the preatheromatous stage.
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000503:physiopathology; D001161:Arteriosclerosis / Q000097:blood / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D002908:Chronic Disease; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D004727:Endothelium; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology; D012306:Risk
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL
vernacular_title: Entspricht das Konzept zur Prävention der chronisch ischämischen Herzkrankheit den gegenwärtigen Vorstellungen zur Atiologie und Pathogenese der Arteriosklerose?