Comparison of two infectious bursal disease vaccine strains: efficacy and potential hazards in susceptible and maternally immune birds.
Two infectious bursal disease vaccines were administered to separate groups of maternally immune and susceptible chickens at various ages. Vaccine B caused no damage to the bursae of chickens examined histologically at nine and 20 days after vaccination. The bursae of chickens given vaccine A were shown to be severely damaged when similarly examined. Both vaccines protected all the susceptible groups against challenge, but only vaccine A protected the groups of maternally immune chickens. Susceptible chickens vaccinated at one day of age with vaccine A showed a lowered response to Hitchner B1 Newcastle disease vaccine given at 14 days of age, judged by the haemagglutination-inhibition response and Newcastle disease challenge. The performance of the Newcastle disease vaccine was not affected in chickens given vaccine B. Bedding used by birds given vaccine A was shown to be capable of transmitting vaccinal virus to susceptible chickens, causing severe bursal damage.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007165:Immunosuppression Therapy; D007243:Infectious bursal disease virus / Q000276:immunology*; D009522:Newcastle disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000009:adverse effects*
D000914:Antibodies, Viral; D014765:Viral Vaccines