The central action of drugs affecting beta-adrenergic receptor. IV. The influence of intraventricularly administered drugs affecting beta-adrenergic receptor on blood pressure in rats.
Isoprenaline, propranolol, alprenol and sotalol administered intraventricularly (ivc) to anaesthetized rats induce hypotension. Propanolol and alprenolol given ivc to rats pretreated with isoprenaline increase blood pressure up to the values equal to those, previous to isoprenaline administration; another isoprenaline dose acts slightly hypotensively.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000526:Alprenolol / Q000032:analysis / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008722:Methods; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013015:Sotalol / Q000008:administration & dosage / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000526:Alprenolol; D011433:Propranolol; D013015:Sotalol; D007545:Isoproterenol