[Influence of dental caries prophylaxis using fluor-vigantoletten 1000 on plasma fluoride levels in infants (author's transl)].
A group of 57 newborns was divided into two: group I (27 subjects) received solely 1,000 I.U. vitamin D3 per day for 6 months, whereas group II (30 subjects) were given a combination of 1,000 I.U. vitamin D3 and 0.25 mg fluoride. At the end of the time of observation there was a significant difference between the plasma concentrations in the two groups. The median value was 13.06 microgram/l (range: 8:18-39.4 microgram/l) in group I and 16.54 microgram/l (range: 9.9--41.2 microgram/l) in group II. Fluoride is obviously available to infants when administered in combination with Vitamin D3. In addition, it could be proven, that after 6 month administration of fluoride there are no signs of cumulation, overdosage or even intoxication.
D002762:Cholecalciferol / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D005459:Fluorides / Q000008:administration & dosage* / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011446:Prospective Studies
D002762:Cholecalciferol; D005459:Fluorides
Einfluss der Kariesprophylaxe mit Fluor-Vigantoletten 1000 auf die Plasma-Fluoridkonzentrationen beim Säugling.