Suppression and regression of a transplanted tumor in the guinea pig colon mediated by Mycobacterium bovis, strain BCG.
The growth in the colon wall of a diethylnitrosamine-induced hepatocarcinoma was suppressed by BCG. Injection of BCG into established colon-wall tumors caused tumor regression. Successful therapy required a limited tumor burden. Guinea pigs in which growth of the neoplasm was suppressed at the site of BCG infection developed systemic tumor transplantation immunity.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D006084:Graft Rejection; D006168:Guinea Pigs; D008113:Liver Neoplasms; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000628:therapy; D009602:Nitrosamines
D001500:BCG Vaccine; D002273:Carcinogens; D009602:Nitrosamines