title: [Vaccination using an inactivated vaccine on a pig-breeding farm infected with the virus causing Aujeszky's disease (author's transl)].
abstract: When Aujeszky's disease was detected on a large pig-breeding farm, all normal sows and boars were vaccinated with an ethyl-ethylene-imine (EEI) vaccine produced in the Bundesforschungsanstalt für Viruskrankheiten der Tiere (Federal Research Institute for Viruses Diseases in Animals) in Tübbingen, Western Germany. The vaccine contained DEAE dextran as an adjuvant. The vaccine was inoculated twice by intramuscular route at a three weeks' interval, 5 ml. being inoculated at one time. Hyperimmune serum was inoculated in young pigs. In addition, hygienic procedures were adopted, consisting in disinfection and isolation. The disease was successfully controlled within eight weeks. Sows which developed Aujeszky's disease showed hardly any symptoms suggesting lesions of the central nervous system. Pulmonary lesions were the outstanding clinical feature. The semen quality of the affected male swine had markedly deteriorated. This was resorted to normal, however, within from five to ten weeks. The incidence of abortion and piglet mortality were low. In view of the results of virological and serological studies, it was concluded that the persistence of this strain of virus (causing Aujeszky's disease) was very slight.
mesh_terms: D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary; D005260:Female; D006564:Herpesviridae / Q000276:immunology*; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D006920:Hygiene; D008297:Male; D009426:Netherlands; D011247:Pregnancy; D011557:Pseudorabies / Q000453:epidemiology / Q000517:prevention & control*; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000517:prevention & control*; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D014765:Viral Vaccines
vernacular_title: Vaccinatie met een geïnactiveerd vaccin op een met het virus van de ziekte van Aujeszky besmet varkensfokbedrijf.