title: CSF levels of cyclic nucleotides in primary intracranial neoplasms: a preliminary report.
abstract: Recent evidence indicates that cyclic nucleotides are of importance for general and neurosurgical oncology, especially with respect to the contact-inhibition mechanisms and tumour cell growth. This preliminary report deals with the CSF levels of c-AMP and c-GMP in primary neoplasms in children and to problems related to the blood-brain barrier. Some cases of medulloblastoma were studied as well as a few cases of brain stem glioma and cystic astrocytoma. The importance of some rather unusual findings seems undebatable, i.e., the marked increase in c-GMP values usually observed in medulloblastoma and the decrease of c-AMP, that is fairly common in all malignant neoplasms. The main changes in the c-AMP/c-GMP ratio are also discussed.
mesh_terms: D001254:Astrocytoma / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000601:surgery; D001933:Brain Stem; D002528:Cerebellar Neoplasms / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D006152:Cyclic GMP / Q000134:cerebrospinal fluid*; D005910:Glioma / Q000134:cerebrospinal fluid*; D006801:Humans; D007223:Infant; D008527:Medulloblastoma / Q000134:cerebrospinal fluid*
chemical_list: D000242:Cyclic AMP; D006152:Cyclic GMP