Acromegaly due to production of a growth hormone releasing factor by a bronchial carcinoid tumor.
We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperosidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary monolayer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a production.
D000172:Acromegaly / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D001984:Bronchial Neoplasms / Q000150:complications / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000150:complications / Q000378:metabolism*; D002478:Cells, Cultured; D004298:Dopamine / Q000494:pharmacology; D013006:Growth Hormone / Q000096:biosynthesis / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D004298:Dopamine