ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta-endorphin.
ACTH, beta-lipotropin (beta-LPH) and beta-endorphin concentrations were determined in pituitary adenomas of the patients with Cushing's disease. Immunoreactive ACTH and beta-endorphin were present in high concentrations and essentially equimolar amounts in pituitary adenomas. beta-LPH conversion to beta-endorphin was activated in pituitaries associated with ACTH/beta-LPH producing adenomas. Immunoreactive ACTH and beta-endorphin concentrations were markedly suppressed in the surrounding tissues.
D000236:Adenoma / Q000150:complications* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D003480:Cushing Syndrome / Q000150:complications* / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism*; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism; D008083:beta-Lipotropin / Q000378:metabolism*
D004723:Endorphins; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin