[Effect of cAMP on the structural and functional properties of the erythrocytes].
Cyclic AMP inhibits the anion transport and decreases the osmotic resistance and deformability of erythrocytes with the normal level of ATP. With ATP-depleted erythrocytes cAMP exerted the opposite effects on the corresponding characteristics. In addition, it was observed that the pattern of cAMP effect on the cell form depends on the basal level of ATP. These effects may be associated with the two types of structural rearrangements of erythrocyte membranes established earlier: a cooperative transition not connected with protein kinase system, and a non-cooperative one caused by protein phosphorilation.
D001693:Biological Transport, Active / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D004548:Elasticity; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D009996:Osmotic Fragility / Q000187:drug effects
D000242:Cyclic AMP
Vliianiie tsAMF na strukturno-funktsional'nye svoĭstva éritrotsitov.