[Pituitary adenomas with cells containing bêta MSH, alpha and bêta endorphins and without ACTH (author's transl)].
By using immunohistoenzymatic techniques, cells of 4 pituitary adenomas are revealed with beta MSH, alpha and beta endorphins antisera but do not react with 1--24 and 17--39 ACTH antisera. These data suggest that adenomatous cells are able to synthesize and LPH-like molecule without ACTH. The levels of plasmatic LPH and beta MSH, studied by RIA, stay normal. These results are discussed.
D000236:Adenoma / Q000032:analysis*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D000328:Adult; D004723:Endorphins / Q000032:analysis*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis* / Q000097:blood; D008854:Microscopy, Electron; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000032:analysis*; D008083:beta-Lipotropin / Q000097:blood
D004723:Endorphins; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin
Adénomes hypophysaires avec cellules à bêta MSH et à alpha et bêta endorphines sans ACTH.