Changes in lymphocyte beta-adrenergic receptors in depression and mania.
The beta-adrenergic receptors were studied in vitro in lymphocytes obtained from patients with major affective disorders and controls. Specific L-[3H]-dihydroalprenolol binding was decreased in both depressed and manic patients compared to controls and euthymic patients. Isoproterenol-stimulated, but not prostaglandin El-stimulated, cyclic adenosine-3',5'-monophosphate production was decreased in manic and depressed patients. These results suggest decreased lymphocyte beta-receptor functioning in depression and mania. This decrease may be an index of changes in brain beta-receptors in mania and depression, or may simply reflect homeostatic regulation of peripheral beta-receptors in response to stress-induced increases in circulating catecholamines.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D002986:Clinical Trials as Topic; D000242:Cyclic AMP / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D003891:Desipramine / Q000627:therapeutic use; D004082:Dihydroalprenolol / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008094:Lithium / Q000627:therapeutic use; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D011458:Prostaglandins E / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*; D013268:Stimulation, Chemical
D011458:Prostaglandins E; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D008094:Lithium; D000242:Cyclic AMP; D007545:Isoproterenol; D003891:Desipramine