title: ACTH-like peptides and opiate receptors in the rat brain: structure-activity studies.
abstract: The present study aims at further identifying the interaction of ACTH-like peptides and rat brain opiate receptors in vitro. The sequence ACTH4-10 is crucial with respect to affinity since it is the shortest sequence to inhibit the binding of [3H]-dihydromorphine and [3H]-naltrexone to these receptors. A second active site seems to be localized in the N-terminal part of ACTH11-24. This structure-activity relationship is compared to that observed for these peptides on the adrenal cortex and behavior.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000595:Amino Acid Sequence; D000701:Analgesics, Opioid / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011955:Receptors, Drug; D013329:Structure-Activity Relationship
chemical_list: D000701:Analgesics, Opioid; D010455:Peptides; D011955:Receptors, Drug; D000324:Adrenocorticotropic Hormone