Mechanisms of PGF2 alpha action in functional luteolysis.
The luteolytic action of PGF2 alpha appears to be due to loss of gonadotropin support of corpus luteum function. This "chemical hypophysectomy" produced by PGF2 alpha in the rat has several components: 1. A rapid block of gonadotropin uptake in vivo by an unexplained mechanism. 2. A rapid and direct block of adenylate cyclase activation by the LH receptor complex in isolated luteal cells. 3. An eventual loss of LH receptor binding activity produced by inhibition of prolactin action.
D004092:20-alpha-Dihydroprogesterone / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D003338:Corpus Luteum / Q000098:blood supply / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004971:Estrus; D005260:Female; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors*; D003341:Luteolysis / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects
D006065:Gonadotropins, Pituitary; D011460:Prostaglandins F; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone; D007986:Luteinizing Hormone; D000242:Cyclic AMP; D000262:Adenylyl Cyclases