Beta-oxidation in peroxisomes of brown adipose tissue.
Peroxisomes and mitochondria from brown adipose tissue of the rat were separated by differential pelleting and isopycnic gradient centrifugation. Both fractions oxidized palmitoyl-CoA with comparable specific activities. Unlike the mitochondrial beta-oxidation the peroxisomal activity was not influenced by carbon monoxide. Peroxisomal beta-oxidation together with carnitine acetyl-transferase, which is also located in peroxisomes, might be involved in chemical thermogenesis by delivering acetyl groups to the mitochondria.
D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000648:ultrastructure; D001833:Body Temperature Regulation; D002374:Catalase / Q000378:metabolism; D044943:Fatty Acid Desaturases / Q000378:metabolism; D008830:Microbodies / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009940:Organoids / Q000378:metabolism*; D010084:Oxidation-Reduction; D010171:Palmitoyl Coenzyme A / Q000378:metabolism
D009243:NAD; D010171:Palmitoyl Coenzyme A; D002374:Catalase; D044943:Fatty Acid Desaturases