Effect of p-chloromercuribenzene sulfonate on gastric parietal and surface cell function in the dog.
p-Chloromercuribenzene sulfonate, a polar organic mercurial which presumably penetrates cell membranes with great difficulty, led to a profound decrease in acid recovered from exteriorized segments of dog gastric fundus stimulated by exogenous histamine. Trapping of secreted hydrogen ions by Tris buffer did not significantly reduce the back-diffusion component of apparent inhibition. Sodium-for-hydrogen exchange was close to unity before and after inhibition.
D000818:Animals; D002021:Buffers; D002462:Cell Membrane / Q000187:drug effects; D002729:Chloromercuribenzoates / Q000494:pharmacology*; D004285:Dogs; D005745:Gastric Acidity Determination; D005750:Gastric Juice; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006859:Hydrogen / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013451:Sulfonic Acids / Q000494:pharmacology
D002021:Buffers; D002729:Chloromercuribenzoates; D013451:Sulfonic Acids; D006859:Hydrogen; D006632:Histamine