Voltage-dependent calcium and potassium ion conductances: a contingency mechanism for an associative learning model.
Persistent light-induced depolarization results from Ca2+ influx across a photoreceptor membrane. The marked dependence on potential of this Ca2+ influx and a Ca+-dependent K+ efflux accounts for enhancement of the light-induced depolarization when light is paired with rotation. A positive feedback cycle between light-induced depolarization and synaptic depolarization due to stimulus pairing can explain long-lasting behavioral changes produced by associative training but not control paradigms. The sensitivity of this Ca2+ influx to intracellular levels of adenosine 3'-5'-monophosphate suggests biochemical steps for this model of associative learning.
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology; D004594:Electrophysiology; D007478:Iontophoresis; D007858:Learning / Q000502:physiology*; D008564:Membrane Potentials; D008974:Mollusca / Q000502:physiology*; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D012399:Rotation; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D013757:Tetraethylammonium Compounds; D000242:Cyclic AMP; D011188:Potassium; D002118:Calcium