title: The effect of chronic ammonium chloride ingestion on parathyroid hormone function.
abstract: The purpose of this study was to examine the effect of ammonium chloride ingestion on the hypercalcemic effect of parathyroid hormone in vivo. Thyroparathyroidectomized rats were given 1.5% ammonium chloride for 5-6 days. Ingestion of ammonium chloride increased serum calcium, but also significantly enhanced the calcium elevating effect of injected parathyroid extract. This result is compatible with a proposed hypothesis that the calcium mobilizing function of the parathyroid hormone may be enhanced by the hormone's own influence on systemic hydrogen ion concentration.
mesh_terms: D000284:Administration, Oral; D000471:Alkalosis / Q000139:chemically induced; D000643:Ammonium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001769:Blood; D002118:Calcium / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006934:Hypercalcemia / Q000139:chemically induced; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology*; D051381:Rats; D013961:Thyroid Gland / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D000643:Ammonium Chloride; D002118:Calcium