Demonstration of cells with Marek's disease tumor-associated surface antigen in chicks infected with herpesvirus of turkey, O1 strain.
The presence of Marek's disease tumor-associated surface antigen (MATSA) was demonstrated by the direct and indirect membrane immunofluorescent tests, in chicks inoculated 7-10 days earlier with herpesvirus of turkeys (HVT), O1 strain. In in vitro cultures of spleen lymphocytes and ovaries obtained from these chicks, MATSA-positive cells were also detected after 1-7 days cultivation. A possible mechanism of protection by HVT vaccine against Marek's disease is proposed.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002478:Cells, Cultured; D002645:Chickens; D005260:Female; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000662:veterinary*; D008214:Lymphocytes / Q000276:immunology; D008380:Marek Disease / Q000276:immunology*; D010053:Ovary / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology*; D014765:Viral Vaccines
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D014765:Viral Vaccines