Possible mechanism of rubidium-induced hyperactivity in the rat.
This study suggests that replacement of intracellular potassium by rubidium ions might lower the resting membrane potential. Thus rubidium-treated rats were more responsive to depolarizing influences and generated more cyclic AMP in the brainstem and consequently the behavioral changes.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012413:Rubidium / Q000494:pharmacology*; D014018:Tissue Distribution
D000242:Cyclic AMP; D012413:Rubidium; D011188:Potassium