Molecular mechanism of general anesthesia: II. Spin label studies on synaptic membranes.
In this communication we report the effects of general anesthetics on the mobility and order of spin labeled stearic acid derivatives in synaptic membranes and in bilayers formed from the lipids extracted therefrom. The anesthetics studied abolish the immobilization induced by synaptic membrane proteins on the membrane lipids : this effect, observed particularly in the bilayer core, is interpreted as a labilization of lipid-protein interactions induced by anesthetics.
D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects; D000440:Butanols / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D006221:Halothane / Q000494:pharmacology; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000032:analysis; D008928:Mitochondria / Q000187:drug effects*; D013113:Spin Labels; D013552:Swine; D013570:Synaptic Membranes / Q000187:drug effects*; D013574:Synaptosomes / Q000187:drug effects
D000777:Anesthetics; D000440:Butanols; D008563:Membrane Lipids; D013113:Spin Labels; D007649:Ketamine; D006221:Halothane