title: The effect of tetrathiomolybdate upon sheep caeruloplasmin amine oxidase activity in vitro: the influence of substrate on apparent sensitivity to inhibition.
abstract: The effect of molybdate, dithiomolybdate, tetrathiomolybdate and diethyldithiocarbamate on caeruloplasmin amine oxidase activity was examined using o-dianisidine as a substrate. Enzyme activity was strongly inhibited by tetrathiomolybdate (1.5 X 10(6)M), oxidation of another substrate, p-phenylenediamine, was inhibited only slightly.
mesh_terms: D000818:Animals; D002570:Ceruloplasmin; D003962:Dianisidine / Q000097:blood; D004050:Ditiocarb / Q000494:pharmacology; D008982:Molybdenum / Q000494:pharmacology*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D012756:Sheep / Q000097:blood*; D013440:Sulfides
chemical_list: D013440:Sulfides; D008982:Molybdenum; C020809:tetrathiomolybdate; D004050:Ditiocarb; D002570:Ceruloplasmin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D003962:Dianisidine