[Development of immunity to the poliomyelitis virus in infants with various methods of administering a live poliomyelitis vaccine].
The data have been obtained which indicate that the effectiveness of vaccination with live trivalent poliomyelitis vaccine may be increased and 90--100% of the vaccinated infants under 1 year of age may develop marked resistance of the alimentary tract and high antibody titers in the blood serum to the threee types of poliomyelitis virus in the course of 3 vaccinations. Some regularities of the formation of immunity to individual poliomyelitis virus types in the course of 4 vaccinations with trivalent vaccine were revealed and specified. The results indicate that the contact of vaccine virus with the oropharyngeal tissues during immunization has a favourable effect on the development of immunity. Vaccination of infants under 1 at 6-week intervals between vaccine feedings creates solid immunity in 90--100% vaccines. Administration of the next vaccine dose 6 weeks after the previous one stops multiplication of the dominating type of vaccine virus and prevents its long-term passage in the intestinal tract decreasing the probability of emergence of vaccine virus variants with increased pathogenicity.
D000914:Antibodies, Viral / Q000032:analysis; D002214:Capsules; D005243:Feces / Q000382:microbiology; D006801:Humans; D007109:Immunity; D007114:Immunization; D007115:Immunization Schedule; D007223:Infant; D009500:Neutralization Tests; D010614:Pharynx / Q000382:microbiology; D017955:Poliovirus / Q000276:immunology* / Q000302:isolation & purification; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D013997:Time Factors
D000914:Antibodies, Viral; D002214:Capsules; D011055:Poliovirus Vaccine, Oral
Razvitie immuniteta k virusu poliomielita u deteĭ rannego virusa pri razlichnykh sposobakh vvedeniia zhivoĭ poliomielitnoĭ vaktsiny.