Hazards of hepatic artery infusion of streptozocin.
Three patients with metastatic malignancy received streptozocin by hepatic artery infusion through a percutaneous transfemoral catheter. Two patients developed major arterial thrombosis, from which one died. The other suffered renal damage following displacement of the catheter tip. Possible avoidable risk factors are identified.
D007516:Adenoma, Islet Cell / Q000188:drug therapy; D000328:Adult; D002276:Carcinoid Tumor / Q000188:drug therapy; D002404:Catheterization / Q000009:adverse effects; D002445:Celiac Artery; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial; D007674:Kidney Diseases / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008638:Mesenteric Arteries; D008875:Middle Aged; D011859:Radiography; D013311:Streptozocin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced*
D013311:Streptozocin