Complexes of derivatives of 1-nitro-9-aminoacridine with DNA.
Substituted 1-nitro-9-aminoacridine derivatives were shown to inhibit RNA and to a lesser extent protein synthesis in cultured human cells. Complex formation between the compounds studied and DNA were considered to be responsible for their cytostatic action. Two types of complexes differing in their binding forces were found. The biological activity of the studied compounds seems not to be dependent on the existence of a positive charge on the acridine ring.
D000166:Acridines / Q000494:pharmacology; D000585:Aminacrine / Q000031:analogs & derivatives; D000588:Amines / Q000494:pharmacology; D001665:Binding Sites; D002250:Carbon Radioisotopes; D002277:Carcinoma; D002413:Cations, Divalent; D002414:Cations, Monovalent; D002460:Cell Line; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000032:analysis; D003864:Depression, Chemical; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009062:Mouth Neoplasms; D009574:Nitro Compounds / Q000494:pharmacology; D009691:Nucleic Acid Denaturation; D010649:Phenylalanine / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D000166:Acridines; D000588:Amines; D002250:Carbon Radioisotopes; D002413:Cations, Divalent; D002414:Cations, Monovalent; D009574:Nitro Compounds; D014316:Tritium; C010493:1-nitro-9-aminoacridine; D010649:Phenylalanine; D012313:RNA; D000585:Aminacrine; D004247:DNA; D014529:Uridine