6 beta-Bromopenicillanic acid inactivates beta-lactamase I.
The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.
D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D010397:Penicillanic Acid / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid