Effect of prostaglandins on the increased corticosterone output induced by caffeine in the rat.
The effect of prostaglandins on the increase of corticosterone output induced by caffeine was investigated in rats. PGE2 and some synthetic prostaglandins (11-deoxy-derivatives), which stimulate steroid output in vitro, enhanced the effect of caffeine. Pretreatment with indomethacin inhibited the effect of caffeine.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D003345:Corticosterone / Q000096:biosynthesis* / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats
D011459:Prostaglandins E, Synthetic; D002110:Caffeine; D000242:Cyclic AMP; D003345:Corticosterone; D007213:Indomethacin