5-HT induced accumulation of 3',5'-AMP and the phosphorylation of paramyosin in the ABRM of Mytilus edulis.
In Mytilus edulis 5-Ht induced relaxation of a muscle in catch is preceded by an increase in 3',5'-AMP content. In vitro two proteins of the contractile apparatus are phosphorylated by 3',5'-AMP dependent protein kinases. The 295000 dalton protein cannot be identified, the other one is paramyosin. Phosphorylated paramyosin inhibits actomyosin ATPase of smooth mollusc muscles at low and high Ca++ concentrations.
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D049872:Bivalvia; D000242:Cyclic AMP / Q000378:metabolism*; D009130:Muscle, Smooth / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D014335:Tropomyosin / Q000378:metabolism*
D014335:Tropomyosin; D012701:Serotonin; D000205:Actomyosin; D000242:Cyclic AMP; D011494:Protein Kinases; D000251:Adenosine Triphosphatases