Decreased binding of polymyxin by polymyxin-resistant mutants of Salmonella typhimurium.
Polymyxin-resistant pmrA strains were shown to absorb only about 25% of the amount of polymyxin absorbed by the corresponding polymyxin-sensitive parent strains. The lipopolysaccharide from the pmrA strains bound less polymyxin than the lipopolysaccharide from the parent strains.
D004352:Drug Resistance, Microbial; D008070:Lipopolysaccharides / Q000378:metabolism*; D008563:Membrane Lipids / Q000032:analysis; D009154:Mutation; D011112:Polymyxin B / Q000378:metabolism* / Q000494:pharmacology; D011113:Polymyxins / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects / Q000378:metabolism*
D008070:Lipopolysaccharides; D008563:Membrane Lipids; D011113:Polymyxins; D011955:Receptors, Drug; D011112:Polymyxin B