[Controlled research of the influence of Neoston on tracking performance, heart rate, sinus arrhythmia and on subjective rating of healthy subjects].
The influence of Neoston--a relatively new analgesic, antipyretic, and anti-inflammatory agent--on performance in different tracking tests, on heart rate, on sinus arrhythmia and on subjective rating was objectivated. 15 healthy male and female subjects, aged from 19 to 27 years, took part in the sessions lasting about 2 1/2 hrs each. Two times two pills Neoston or a placebo were taken orally 2 and 5 hrs before the tests, making a total of 2 g. Performance in tracking was poorer on the whole with Neoston than with placebo, but only up to a maximum of 5%. Except one measurement point out of 10 all differences between the tests with the active drug and placebo were not statistically significant at the level of 5%. Yet a relatively uniform trend suggests a certain but only a small damping effect of Neoston. When relating the data of the second and third session on the data of the first session of each day, damping effects could be made more obvious. Hereby the influence of Neoston on tracking performance could be demonstrated to exist also statistically significant but to be practically almost irrelevant. In physiological variables as well as in subjective rating only small differences between the drug and placebo condition were measured. When relating the results to comparable research on the effects of alcohol, tranquilizers and stimulants, it is concluded that with Neoston in the relatively high dosage as used here, no real detrimental effects on traffic safety are to be expected.
D000328:Adult; D001146:Arrhythmia, Sinus / Q000503:physiopathology; D001334:Automobile Driving; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D005222:Mental Fatigue; D009048:Motor Skills / Q000187:drug effects*; D010648:Phenylacetates / Q000494:pharmacology*; D012647:Self-Assessment; D013647:Task Performance and Analysis
D010648:Phenylacetates
Kontrollierte prüfung des Einflusses von Neoston auf das Regelleistungsverhalten, auf die Herzfrequenz und Sinusarrhythmie und auf das subjektive Befinden gesunder Versuchspersonen in Tracking-Tests