[The possibility of predicting the degree of plasmacyte reaction in response to administration of soluble antigen to mice].
The work is devoted to the mathematical description of the accumulation of plasma cells in the spleen of CBA mice immunized intraperitoneally. A dependence between the dynamics of the soluble antigen concentration in the blood and the plasmocytic reaction in the spleen was confirmed under experimental conditions. Index A was suggested for detection of a change from the antigenic function to the accumulation of plasma cells. The mean values of index A were used to compare the calculated values of the plasmocytic reaction and the experimental data; differences between these values were insignificant. Analogously index A was used for predicting the accumulation of plasma cells in the animals to which a mixture of the two soluble antigens (a capsular antigen of the causative agent of plague and a complete antigen of the causative agent of tularemia) was administered. The calculated values of the plasmocytic reaction in this experiment satisfactorily correlated with the data obtained experimentally.
D000818:Animals; D000942:Antigens, Bacterial; D002454:Cell Differentiation; D005604:Francisella tularensis / Q000276:immunology*; D006386:Hemagglutination Tests; D008433:Mathematics; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology*; D008954:Models, Biological; D009500:Neutralization Tests; D010930:Plague / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology*; D012995:Solubility; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D014406:Tularemia / Q000276:immunology; D014611:Vaccination; D015010:Yersinia pestis / Q000276:immunology*
D000942:Antigens, Bacterial
Vozmozhnosti predskazaniia urovnia plazmotsitarnoĭ reaktsii v otvet na vvedenie mysham rastvorimogo antigena