title: [Physiological basis of homeostasis of the extracellular fluid volume].
abstract: Renal, glomerular and tubular, factors responsible for the volume control of extracellular liquid were examined. The part played by angiotensin II in mediating the compensation of this liquid losses was studied in patients with spontaneous polyuria due to diencephalo-posthypophyseal diabetes insipidus or psychogenic polydipsia and healthy subjects with induced hypotonic polyuria. It was noted that: 1) acute expansion elicited a natriuretic response and increased distal sodium load, due to an increase in filtrate and relative inhibition of proximal reabsorption, or proximal inhibition if the filtrate was unchanged. The efficiency of distal sodium transport was often unchanged. 2) Return to sodium balance parity during prolonged expansion of volume, was accomplished by varying renal means, in accordance with the experimental model employed. Distal reabsorption was essentially depressed during prolonged saline load (secondary hypoaldosteronism). When protracted mineralcorticoid treatment was used, however, distal reabsorption was high, even in the escape stage, and its saturation required marked augmentation of the sodium load reaching the distal tubules. 3) Depletion of volume caused by protracted natriuretic treatment in spontaneous polyuria reduced both diuresis and sodium excretion. This resistance to the natriuretic effect of the drug followed intrarenal compensation that reduced the distal sodium load and encouraged reabsorption in some distal sites (secondary hyperaldosteronism). 4) Infusion of angiotensin II in sub- or pauci-pressor doses causes an isosmotic sodium saving, since it reduced the glomerular filtrate and increases the fraction of filtrate reabsorbed by the proximal tubules; the tubular effect is likely secondary to increased vascular, especially postglomerular resistance. In the healthy subject, angiotensin II leads to antidiuresis referable, on account of its intensity and longer time cycle, to ADH release angiotensin-dependent.
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D003919:Diabetes Insipidus / Q000378:metabolism / Q000503:physiopathology; D004231:Diuresis; D005110:Extracellular Space / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006706:Homeostasis; D006801:Humans; D007408:Intestinal Absorption; D007687:Kidney Tubules, Proximal / Q000503:physiopathology; D009994:Osmolar Concentration; D009997:Osmotic Pressure; D011141:Polyuria / Q000378:metabolism / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance
chemical_list: D000804:Angiotensin II; D012964:Sodium
vernacular_title: Basi fisiologiche dell'omeostasi di volume del liquido extracellulare