Renal prostaglandins.
Relative renal ischemia, produced by a variety of interventions, is modulated or buffered by prostaglandins synthesized within the kidney. These prostaglandins, however, do not account for renal autoregulation in its classic sense. They can facilitate salt and water excretion, largely through effects on physical forces in proximal peritubular capillaries, as evidenced by augmented renal blood flow. Renal prostaglandins may play a role in chronic water balance, but they probably are not important in chronic electrolyte homeostasis. There are several potential mechanisms by which renal prostaglandins could exert antihypertensive efects. Establishment of the importance of these agents, however, as antihypertensive hormones remains a challenge for future investigation.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001692:Biological Transport; D002196:Capillaries / Q000502:physiology; D004231:Diuresis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000098:blood supply; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009318:Natriuresis; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use; D012039:Regional Blood Flow; D014666:Vasomotor System / Q000502:physiology; D014882:Water-Electrolyte Balance
D001095:Arachidonic Acids; D011453:Prostaglandins; D000804:Angiotensin II; D006899:Mixed Function Oxygenases; D000429:Alcohol Oxidoreductases; D007213:Indomethacin