The effects of ultraviolet and ionizing radiation on herpesviruses, SV40 and adenoviruses in relation to the small-plaque effect.
The small-plaque effect occurs with a wide range of herpesviruses following irradiation with ultraviolet light. The 37 per cent survival (D37) values, or dose required for one lethal hit (e-1), for herpes simplex, pseudorabies and pigeon herpesviruses in different cells indicate a broad spectrum of host-cell repair capacity. Other DNA-containing viruses such as SV40 and adenoviruses, which also replicate in the cell nucleus, show the small-plaque effect. Ionizing irradiation of herpes simplex virus type 1 (HSV-1) showed but little reduction in plaque-size.
D000260:Adenoviruses, Human / Q000254:growth & development / Q000528:radiation effects*; D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006564:Herpesviridae / Q000254:growth & development / Q000528:radiation effects*; D006801:Humans; D011839:Radiation, Ionizing; D013539:Simian virus 40 / Q000254:growth & development / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014779:Virus Replication / Q000528:radiation effects*