Genesis of a virus-transforming gene.
The gene src responsible for neoplastic transformation of fibroblasts by avian sarcoma viruses was apparently derived from highly conserved nucleotide sequences in the normal avian genome. The cellular homologue of src is unlinked to the genome of an endogenous virus in chicken cells and functions in an unknown manner during normal cell metabolism.
D001355:Alpharetrovirus / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D002471:Cell Transformation, Neoplastic; D002645:Chickens / Q000235:genetics; D005796:Genes; D005814:Genes, Viral; D013045:Species Specificity; D014158:Transcription, Genetic