Immunopathology of mouse hepatitis virus type 3mii. effect of immunosuppression in resistant mice.
Normal adult A strain mice are resistant to MHV-3 infection. A strain mice immunosuppressed by 600 rads of x-irradiation or by anti-lymphocyte serum treatment became susceptible to the virus and died with specific lesions of the liver and high virus titers. However, mice immunized with MHV-3 before sublethal x-iraddiation resisted a second injection of virus. Resistant adult (A times C3H) F-1 hybrids undergoing graft-vs-host (GVH) reaction became highly susceptible to MHV-3 injected 8 days after parental cell injection. Virus titer 3 days after injection was 2 logs higher in mice undergoing GVH than in controls. However F-1 hybrid mice resisted virus challenge when the first injection of virus was given 2 weeks before GVH induction. In addition, thymectomy also modified the behavior of resistant animals toward virus infection. It appears, therefore, that cell-mediated immune functions play an important role in resistance of mice to MHV-3.
D000818:Animals; D000831:Animals, Newborn; D000961:Antilymphocyte Serum; D006087:Graft vs Host Reaction; D006520:Hepatitis, Animal / Q000276:immunology*; D007109:Immunity / Q000528:radiation effects; D007165:Immunosuppression Therapy; D008212:Lymphocyte Depletion; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D006517:Murine hepatitis virus / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D011830:Radiation Effects; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000961:Antilymphocyte Serum