title: The effect of sodium thiocyanate on virus structure.
abstract: A study of two different virus types after elution from immunosorbent columns by sodium thiocyanate has shown that virus degradation occurs. The two virus types studied were hepatitis B and rotavirus. Hepatitis B antigen (HBAg) was only slowly degraded and retained many of its morphological features, although in an altered form; rotavirus was highly sensitive to the chaotropic agent, losing both its viability and its morphological integrity. During the process of disassembly a previously undetected inner component of rotavirus could be visualised, which was termed the "core."
mesh_terms: D002213:Capsid / Q000648:ultrastructure; D006511:Hepatitis B Antigens; D006515:Hepatitis B virus / Q000187:drug effects* / Q000648:ultrastructure; D007163:Immunosorbent Techniques; D012328:RNA Viruses / Q000187:drug effects*; D012087:Reoviridae / Q000187:drug effects* / Q000648:ultrastructure; D012401:Rotavirus / Q000187:drug effects* / Q000648:ultrastructure; D013861:Thiocyanates / Q000494:pharmacology*; D014776:Virus Cultivation
chemical_list: D006511:Hepatitis B Antigens; D013861:Thiocyanates