title: Effect of ACTH on the relaxation of guinea pig trachea with various bronchodilators.
abstract: The effect of ACTH on the actions of various bronchodilators was examined using the isolated guinea pig tracheal smooth muscle. Relaxing effects of isolated guinea pig tracheal smooth muscle with 1-isoproterenol hydrochloride, salbutamol hemisulfate, hexoprenaline hydrochloride and epinephrine except prostaglandin E2 and aminophylline were markedly potentiated by combining ACTH. These results may suggest that ACTH has a direct effect on guinea pig tracheal smooth muscle by potentiating the actions of various beta-receptor stimulators.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects*; D000420:Albuterol / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D006594:Hexoprenaline / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
chemical_list: D001993:Bronchodilator Agents; D011458:Prostaglandins E; D000628:Aminophylline; D000324:Adrenocorticotropic Hormone; D006594:Hexoprenaline; D007545:Isoproterenol; D000420:Albuterol; D004837:Epinephrine