[Effect of heparin, spermidine and Be2+ ions on the phosphatase and RNAse activity of rat liver cell nuclei].
Effects of heparin, spermidine, and Be2+ ions on the ATPase and beta-glycerophosphatase and RNA-ase activities of the rat liver cell nuclei were studied. Be2+ was shown to inhibit the ATPase activity and, to a lesser extent, beta-glycerophosphatase activities. Physiological concentrations of heparin and spermidine also lowered the mentioned two activities, as well as the RNAase activity of the nuclei. Evidence is presented for the inhibitory effect of heparin and spermidine on endonucleases.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001608:Beryllium / Q000494:pharmacology*; D002413:Cations, Divalent; D002467:Cell Nucleus / Q000187:drug effects* / Q000201:enzymology; D003864:Depression, Chemical; D004789:Enzyme Activation / Q000187:drug effects; D005994:Glycerophosphates; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism*; D013095:Spermidine / Q000494:pharmacology*
D002413:Cations, Divalent; D005994:Glycerophosphates; D006493:Heparin; D012260:Ribonucleases; C020674:glycerol-2-phosphatase; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D001608:Beryllium; D013095:Spermidine
Vliianie geparina, spermidina i ionov Be2+ na fosfataznuiu i RNK-aznuiu aktivnost' iader kletok pecheni krys.