title: Noninfectious vesicular stomatitis virus particles deficient in the viral nucleocapsid.
abstract: Several temperature-sensitive mutants of vesicular stomatitis virus in complementation group III produce, at nonpermissive temperature, noninfectious particles which contain the viral M (matrix) and G (glycoprotein) proteins but less than 10% of the normal proportion of N protein or RNA. Since group III mutants are thought to be defective in the structural gene for the virus M protein, these findings demonstrate that an interaction between M and the nucleocapsid is of importance in virus budding. Taken together with earlier results, they suggest that M is the key protein in bud formation.
mesh_terms: D002460:Cell Line; D005796:Genes; D009154:Mutation; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics*; D013696:Temperature; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics*; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins