title: Contrast and electrolyte dynamics of the intravenous pyelogram. I. Urinary pH and volume changes in the canine I. V. P.
abstract: Canine peripheral venous or suprarenal aortic injections of sodium or meglumine iothalamate produced a significant swing towards an alkaline urine only in individual dogs injected with meglumine salts. When mean values were compared for the sodium or meglumine groups as a whole, however, no significant differences could be established for pH change or induced diuresis. With both salts, ATPase inhibition could play a role in urinary electrolyte excretion. Carbonic anhydrase inhibition does not seem to play a significant role in urinary pH changes induced by contrast media.
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000606:Amino Sugars / Q000032:analysis; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006863:Hydrogen-Ion Concentration; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000494:pharmacology*; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000652:urine; D007668:Kidney / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013012:Sorbitol / Q000031:analogs & derivatives / Q000032:analysis; D013431:Sulfates / Q000494:pharmacology; D014567:Urography
chemical_list: D000606:Amino Sugars; D002257:Carbonic Anhydrase Inhibitors; D013431:Sulfates; D007483:Iothalamic Acid; D013012:Sorbitol; D012964:Sodium; D000251:Adenosine Triphosphatases; D000086:Acetazolamide; D011188:Potassium; D007482:Iothalamate Meglumine