The surface activity of some antihistamines at the air-solution interface.
The surface activity of some antihistamines at the air-solution interface has been examined. Change of the counterion associated with the drug from chloride to maleate or chloro-theophyllinate considerably decreased the critical micelle concentration and increased the surface activity. The effect on surface activity of changes in the nature of the hydrophobic and hydrophilic groups have also been evaluated.
D000388:Air; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006634:Histamine H1 Antagonists; D008823:Micelles; D009994:Osmolar Concentration; D012996:Solutions; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013500:Surface Tension
D006634:Histamine H1 Antagonists; D008823:Micelles; D012996:Solutions