title: In vitro interaction of LDL, anti-lipoprotein IgA and human fibroblasts.
abstract: Human LDL were bound and internalized by cultured human fibroblasts. When an antilipoprotein IgA kappa from a case of myeloma with hyperlipidemia and xanthomatosis was introduced into the system, LDL uptake dropped by 50% but LDL binding to fibroblasts was unchanged. In the same system, IgG and IgA controls were inactive.
mesh_terms: D000328:Adult; D002460:Cell Line; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000276:immunology; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D007147:Immunoglobulin Light Chains / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000276:immunology; D014973:Xanthomatosis / Q000150:complications / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D008077:Lipoproteins, LDL