[The importance of the substrate for the induction of tyrosine-alpha-ketoglutarate-transaminase in RLC-cells (author's transl)].
1. Dexamethasone phosphate causes approximately a threefold increase of the tyrosine-alpha-ketoglutarate transaminase in the culture of RLC cells. 2. The induction of the enzyme depends on the presence of L-tyrosine. Omission of L-leucine or L-tryptophan, respectively, has no effect. 3. Omission of L-tyrosine influences the activity of the lactate dehydrogenase and malate dehydrogenase not at all and that of the glucose-6-phosphate-dehydrogenase only to a small extent. 4. In the absense of L-tyrosine an superinduction takes also place by actinomycin.
D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004790:Enzyme Induction; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D007770:L-Lactate Dehydrogenase / Q000096:biosynthesis; D007930:Leucine / Q000494:pharmacology; D008291:Malate Dehydrogenase / Q000096:biosynthesis; D014364:Tryptophan / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D003609:Dactinomycin; D014443:Tyrosine; D003907:Dexamethasone; D014364:Tryptophan; D003513:Cycloheximide; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D014444:Tyrosine Transaminase; D007930:Leucine
Dei Bedeutung des Substrates bei der Induktion der Tyrosin-alpha-Ketoglutarat-Transaminase in RLC-Zellen