Additional data on hepatic function tests in cystic fibrosis.
Fifty cystic fibrosis (CF) patients, of whom 9 had multilobular cirrhosis, were observed regularly for a period of 3 years and various liver function tests, indicating cytolysis, cholestasis and cellular insufficiency were performed. Immunoglobulin and prothrombin were assayed. In 9 patients with cirrhosis, the tests were generally abnormal. Two distinct biochemical patterns of cirrhosis were distinguished, one clearly cholestatic and the other of a more cellular type. The distinction was made on the basis of the IgA : Transferrin ratio and of gamma-glutamyl-transpeptidase levels. In the non-cirrhotic patients, a temporary increase of cytolysis and cholestasis was observed in 50% of the cases.
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002802:Cholinesterases / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood / Q000201:enzymology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007223:Infant; D007931:Leucyl Aminopeptidase / Q000097:blood; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D009954:Ornithine Carbamoyltransferase / Q000097:blood; D011516:Prothrombin / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D014805:Vitamin B 12 / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012709:Serum Albumin; D014168:Transferrin; D011516:Prothrombin; D009954:Ornithine Carbamoyltransferase; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase; D014805:Vitamin B 12