[Toxicological evaluation of ethyl acetate in conditions of sealed cabin atmospheres].
Ethyl acetate was studied as an atmosphere contaminant in an enclosed environment. A 90-day continuous experiment on 160 white rats and 120 white mice with three concentrations of the compound (43, 10 and 2 mg/m3) was carried out. Ethyl acetate used in the first two concentrations caused functional disturbances in the state of animals and morphological changes in their viscera. Ethyl acetate at a concentration of 2 mg/m3 was ineffective. The data obtained allow recommendations of permissible concentrations of ethyl acetate vapours in an enclosed atmosphere in relation to a different time of man's exposure.
D000085:Acetates / Q000633:toxicity*; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D002802:Cholinesterases / Q000097:blood; D002907:Chronaxy / Q000187:drug effects; D018504:Ecological Systems, Closed; D004906:Erythrocyte Count; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000187:drug effects; D007958:Leukocyte Count; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects; D008452:Maximum Allowable Concentration; D051379:Mice; D051381:Rats; D012701:Serotonin / Q000097:blood; D013961:Thyroid Gland / Q000187:drug effects
D000085:Acetates; D006454:Hemoglobins; D008077:Lipoproteins, LDL; D012701:Serotonin; D002802:Cholinesterases
Toksikologicheskaia otsenka étilatsetata v usloviiakh atmosfery germeticheskikh kabin