[Effect of oxythiamine on pyruvate and lactate metabolism in rat tissues].
The ratio of two substrates (pyruvate and lactate), activity of enzymes, responsible for their turnover in liver tissue, sceletal muscles and blood, were studied simultaneously in experiments on the effect of hydroxythiamin, which was administered at doses, causing a state of hypovitaminosis B1. Hydroxythiamin was shown to inhibit specifically the activity of thiamin-dependent enzymes (transketolase and pyruvate dehydrogenase). It affected also the metabolism of triose phosphates, pyruvate and lactate. At the same time, hydroxythiamin was responsible for changes in activities of other enzymes, participating in turnover of the substrates studied.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009132:Muscles / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010119:Oxythiamine / Q000494:pharmacology*; D010732:Phosphofructokinase-1 / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D011770:Pyruvate Kinase / Q000378:metabolism; D011773:Pyruvates / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000378:metabolism
D007773:Lactates; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D013844:Thiazoles; D010119:Oxythiamine; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D014174:Transketolase; D000410:Alanine Transaminase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase; D005952:Glucose-6-Phosphatase
Vliianie oksitiamina na obmen piruvata i laktata v tkaniiakh krys.