title: Resting-proliferative transition in cultured mammalian cells.
abstract: Cell lines established in culture have been tested for their ability to enter a resting state upon serum step-down. The reentry of resting cells into a proliferative state has been studied. This transition between states of resting and of proliferation is considered a manifestation in cell cultures of physiologic growth regulatory mechanisms. The regulatory effects of hormones and hormone-like peptide growth factors on the resting-proliferative transition are analyzed.
mesh_terms: D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003470:Culture Media; D000242:Cyclic AMP / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D005938:Glucocorticoids / Q000494:pharmacology; D007399:Interphase / Q000187:drug effects; D051379:Mice
chemical_list: D003470:Culture Media; D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D004247:DNA; D000242:Cyclic AMP