Chromosome mutations and pH disturbances.
Chromosomal anomalies, namely hypodiploidies, hyperdiploidies, and endoreduplications, developed in nearly 25% of metaphase plates of replicating human lymphocytes exposed in vitro to either acid (6.5 to 6.9) or alkaline (8.4 to 8.8) pH equilibriums. The G group was most susceptible to aneuploid formation. Mammalian mutations may develop as the result of a pH disturbance during cleavage of the fertilized zygote.
D000782:Aneuploidy; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002902:Chromosomes, Human, 16-18; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008214:Lymphocytes; D008938:Mitosis; D009154:Mutation; D014178:Translocation, Genetic; D014314:Trisomy