Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate.
Acetylsalicylic acid (aspirin) and sodium salicylate are equally effective in reducing the swelling in the carrageenan-induced paw test and the accumulation of leucocytes into the inflammatory exudate produced by the subcutaneous implantation of polyvinyl sponges in the rat. Aspirin but not sodium salicylate caused a significant reduction in the potentiation of paw oedema found after the concurrent administration of carrageenan and arachidonic acid. Some implications of these findings are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001095:Arachidonic Acids; D001241:Aspirin / Q000494:pharmacology*; D002351:Carrageenan; D002464:Cell Migration Inhibition; D005260:Female; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology; D007962:Leukocytes / Q000187:drug effects; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D011453:Prostaglandins; D012459:Salicylates; D002351:Carrageenan; D001241:Aspirin