title: [On the pathogenesis of isocyanate-induced asthma].
abstract: 3 asthmatic patients, occupationally exposed to vapors of toluylene diisocyanate (TDI), responded with a moderate to strong elevation of airway resistance up to the 26th h after inhalation challenge by 0.006--0.02 ppm TDI. No changes in chest radiographs and in DLCO were found. In none of the patients' sera, isocyanate-specific antibodies could be detected by RAST and Ouchterlony test. Change of job resulted in one case in an immediate interruption of the asthmatic symptoms, whereas in 2 patients recovery was slow over a period of 3 to 8 months and not complete. Our investigations suggest a toxic effect of isocyanates, which depends on their concentrations, and an important pharmacological reaction; but, up to now, there were no signs of allergic mechanisms.
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D003485:Cyanates / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D011852:Radioallergosorbent Test; D012129:Respiratory Function Tests; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects* / Q000633:toxicity
chemical_list: D003485:Cyanates; D014051:Toluene 2,4-Diisocyanate
vernacular_title: On the pathogensis of isocyanate-induced asthma.