Ultrastructural immunohistochemical localization of adrenocorticotropin and beta-lipotropin in the rat brain.
In an attempt to identify the cells and organellel containing ACTH and beta-lipotropin in the rat brain, an immunocytochemical localization of these two peptides was performed at the electron microscopic level. Both ACTH and beta-lipotropin were localized in dense core vesicles of about 60-80 nm in diameter. Using serial sections, it has been possible to demonstrate that these peptides are contained not only in the same neuronal cell bodies, but also in the same dense core vesicles.
D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry; D002467:Cell Nucleus / Q000032:analysis / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D008083:beta-Lipotropin / Q000032:analysis*
D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin