Effect of sodium butyrate on the antiviral and anticellular action of interferon in normal and MSV-transformed cells.
Sodium butyrate enhances the antiviral and anticellular action of interferon in MSV-transformed cells but has no such effect in normal cells. The increased sensitivity could be mediated at least partially by the butyrate-induced elaboration of the microtubule and microfilament network.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D002208:Caproates / Q000494:pharmacology; D002472:Cell Transformation, Viral / Q000187:drug effects*; D006224:Cricetinae; D004279:DNA, Viral / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009053:Sarcoma Viruses, Murine / Q000187:drug effects
D000085:Acetates; D002087:Butyrates; D002208:Caproates; D004279:DNA, Viral; D007372:Interferons