The effect of human platelets on lipolytic activity in plasma.
A method for assay of lipolytic activity in platelet-poor plasma (PPP), platelet-rich plasma (PRP) and washed human platelets is presented. The lipolytic activity in PRP was about twice the activity in PPP. A significant correlation between lipolysis in platelets and platelet number was established. Molar sodium chloride strongly inhibited lipolytic activity in platelets and a washing procedure did not significantly change the lipolysis. The results indicate that a lipoprotein lipase is bound to human platelets and may play a role in metabolism of triglyceride in platelets.
D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood; D008297:Male; D011479:Protamines / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013431:Sulfates; D014304:Triolein / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D011479:Protamines; D013431:Sulfates; D014304:Triolein; D012710:Serum Albumin, Bovine; D012965:Sodium Chloride; D008071:Lipoprotein Lipase