[Histology of cerebellar metastasis of bronchial oat cell carcinoma].
Anatomo-pathological examination of 28 bronchic oat-cell carcinoma, all with cerebellar metastases and which are very often cerebral. In half of the cases, these localized cerebellar metastases contain palisades. These formations which haven't been described until now within intracranial metastases, can't be considered as artefacts as their frequency approaches 50% of the cases. Neither the primitive tumor nor the extracerebral metastases of the series reveal palisades; sometimes some of them exist in their cerebral metastases. As far as the epidemiology, the clinical evolution, the survival time and the extracerebral localization are concerned, these 28 cases are not different from those described in medical literature. The morphological, hormonal and biochemical knowledge we possess about this type of cancer tends to prove its neuroectodermic origin as well as its close relation with both the APUD- and the "endocrinien diffus" systems. The described palisading elements represent another very specific morphological point which tends to support this theory: they appear principally in the tumors of the central and peripheral nervous system. Although the author is not able to explain the reason of palisades' genesis in cerebellar metastases, he insists on the fact that it iw very important - as far as every days' biopsy's study is concerned - to proceed to a differential histological diagnosis in regards to certain primitive tumors of the nervous system (among these the medulloblastoma) and a cerebellar metastasis of this type of bronchic carcinoma.
D000368:Aged; D018288:Carcinoma, Small Cell / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure; D002528:Cerebellar Neoplasms / Q000648:ultrastructure*; D002531:Cerebellum / Q000648:ultrastructure; D004292:Dominance, Cerebral; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure
Particularités histologiques des métastases cérébelleuses du carcinome bronchique à cellules en grains d' avoine.