[Problem of increasing the viability of the ischemic myocardium in the light of experimental studies].
With the author's own observations and literature sources as a background the key issues concerned with increasing the viability of the myocardium in acute ischemia are considered. The possibility of a material enlargement of the collateral coronary circulation through administration of mesatonemonoaminoxidase inhibitors, diprazine, preparations of the metabolites type and of other agents is shown. Under consideration are data on the membranes-stabilizing effect in acute ischemia of the myocardium of dimedrol, diprazine and prednisolone, as well as possible ways of increasing the survival of the myocardium by activating the redox-processes and through an adequate supply of energy to ensure the vital functions of the myocardial cell at rest by using pertinent pharmacological agents (cytochrome C, NADP, ubiquinone, hexose-phosphate, monoaminodicarboxylic amino acids).
D000588:Amines / Q000627:therapeutic use; D000818:Animals; D002301:Cardiac Glycosides / Q000627:therapeutic use; D002395:Catecholamines / Q000627:therapeutic use; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004285:Dogs; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006931:Hyperbaric Oxygenation; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D014665:Vasodilator Agents / Q000627:therapeutic use
D000588:Amines; D002301:Cardiac Glycosides; D002395:Catecholamines; D006634:Histamine H1 Antagonists; D008996:Monoamine Oxidase Inhibitors; D014665:Vasodilator Agents
Problema povysheniia zhiznesposobnosti ishemizirovannogo miokarda v eksperimental'nom osveshchenii