[Distribution of the reducing equivalents in the cell in the active phase of benz(a)pyrene metabolism].
Hydroxylation of benz/a/pyrene might occur under decreased activity of NADPH-dependent reductase. In vivo a decrease in the activity of NADPH-dependent reductase did not influence apparently the intensity of benz/a/pyrene hydroxylation, which is maintained due to redistribution of reducing equivalents between oxygenase and oxidase systems in the cells. Anticarcinogenic effects of two different substances chrisene and ubiquinone are discussed taking into account possible normalization of NADPH- and NADH-dependent oxidative reactions in the cells.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D002911:Chrysenes / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006900:Hydroxylation; D008099:Liver / Q000378:metabolism; D008297:Male; D009243:NAD / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D010428:Pentosephosphates / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution / Q000187:drug effects; D014451:Ubiquinone / Q000494:pharmacology
D001580:Benzopyrenes; D002911:Chrysenes; D010428:Pentosephosphates; D009243:NAD; D014451:Ubiquinone; D010088:Oxidoreductases; D009247:NADH, NADPH Oxidoreductases
O raspredelenii vosstanovitel'nykh ékvivalentov v kletke v aktivnoĭ faze metabolizma benz(a)pirena.