[Proteasic polyseritis: effects of intraperitoneal injections of collagenase, alone or together with the administration of trypsin].
The authors showed previously that the effusions of the experimental polyseritis after intraperitoneal injections of trypsin and elastase, go from peritoneum to the pleural cavities and never from thorax to the peritoneum. The intraperitoneal injections of collagenase or of collagenase and trypsin can also cause polyseritis in the rat; but more often they provoke heavy hemorrhagic lesions of the wall of the abdomen and the diaphragm. Perforations of the diaphragm were observed in 8 rats of 32, with in 6, a intrathoracic hernia of the liver or the stomach. After the intrapleural injection of collagenase or of collagenase and trypsin, hemorrhagic lesions were seen in the thorax, but not in the abdomen. These facts are a new proof for the transdiaphragmatic propagation of the proteasic solutions injected in the peritoneum.
D000009:Abdominal Muscles / Q000473:pathology; D000818:Animals; D003964:Diaphragm / Q000473:pathology; D006470:Hemorrhage; D003012:Microbial Collagenase / Q000494:pharmacology*; D051381:Rats; D012700:Serositis / Q000473:pathology*; D012704:Serous Membrane / Q000187:drug effects; D014357:Trypsin / Q000494:pharmacology*
D014357:Trypsin; D003012:Microbial Collagenase
Contribution à l'étude des polysérites protéasiques; effets des injections intrapéritonéales de collagénase, seule ou associée avec l'administration de trypsine.