title: The solubilization of some local anaesthetic ester of p-aminobenzoic acid by lysophosphatidylcholine.
abstract: The solubilization by lysophosphatidylcholine (LPC) of three n-alkyl esters of p-aminobenzoic acid has been studied. These esters have a local anaesthetic action. Quantitative studies show that the amount of compound solubilized is proportional to the LPC concentration and that solubilization increases in the order ethyl, n-propyl and n-butyl ester. 100MHz nmr studies indicate that the local anaesthetic esters are solubilized in the hydrocarbon interior of the LPC.
mesh_terms: D062365:Aminobenzoates / Q000031:analogs & derivatives* / Q000032:analysis; D000779:Anesthetics, Local / Q000032:analysis; D004952:Esters; D008244:Lysophosphatidylcholines; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility
chemical_list: D062365:Aminobenzoates; D000779:Anesthetics, Local; D004952:Esters; D008244:Lysophosphatidylcholines