Immune-complex glomerulonephritis associated with cytomegalovirus infection.
Histologic and immunopathologic studies were performed at autopsy on the kidneys of a patient in whom hematuria and proteinuria developed in association with cytomegalovirus (CMV) pneumonitis. Light microscopic examination of the kidneys revealed focal mesangial proliferative glomerulonephritis. Immunofluorescent microscopy revealed a granular deposition of IgG, IgA, C3, and C4, mainly in the mesangium. CMV antigens were also demonstrated in a similar immunofluorescent pattern. Glomerulus-bound immunoglobulins were eluted and demonstrated to contain antibodies to CMV antigens. These findings suggest that in some patients who have CMV infection immune-complex glomerulonephritis is induced by glomerular deposition of CMV antigen-antibody complexes.
D000942:Antigens, Bacterial; D001344:Autopsy; D003176:Complement C3; D003181:Complement C4; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications / Q000276:immunology / Q000473:pathology
D000942:Antigens, Bacterial; D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007074:Immunoglobulin G