The pineal gland: a biological clock in vitro.
Circadian rhythmicity was studied by following the course of N-acetyl-transferase activity in the pineal glands of chickens in vitro. The results indicate (i) a daily change during day 1 of organ culture in constant dark that was dependent on the time the chickens were killed, (ii) equivocal persistence of the daily change in constant dark during 6 to 7 days of organ culture, (iii) an effect of light, (iv) inhibition by adrenergic agents and cycloheximide, and (v) stimulation by dibutyryl adenosine 3',5'-monophosphate and related compounds.
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D001683:Biological Clocks; D002645:Chickens; D002940:Circadian Rhythm / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology; D008027:Light; D009924:Organ Culture Techniques; D010870:Pineal Gland / Q000201:enzymology / Q000502:physiology*; D012701:Serotonin
D012701:Serotonin; D000242:Cyclic AMP; D000123:Acetyltransferases