Effects of (Bu2)-cAMP and clomiphene on serum concentrations of several proteins and hormones in gonadectomized monkeys.
Sixteen mumol kg-1 of dibutyryl cyclic adenosine 3',5'-monophosphate [(Bu)2cAMP] given intramuscularly to gonadectomized green monkeys (Cercopithecus aetheops sabeus) for two-week periods, produced a significant elevation in the serum concentrations of thyroxine-binding globulin (TBG), fibrinogen, and haptoglobin. No changes were noted in cortisol-binding golbulin (CBG), cortisol, thyroxine, transferrin, total proteins, and albumin. Clomiphene citrate (12.5 mg orally) given concomitantly with (Bu)2cAMP blocked partially the (Bu)2cAMP-induced fibrinogen increment, but not the change in TBG concentration.
D000284:Administration, Oral; D000818:Animals; D003994:Bucladesine / Q000008:administration & dosage / Q000494:pharmacology*; D002369:Castration; D002522:Chlorocebus aethiops; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism*; D000882:Haplorhini; D006242:Haptoglobins / Q000378:metabolism*; D006854:Hydrocortisone / Q000378:metabolism; D007273:Injections, Intramuscular; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism*; D013268:Stimulation, Chemical; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism
D006242:Haptoglobins; D012709:Serum Albumin; D012712:Serum Globulins; D013975:Thyroxine-Binding Proteins; D014168:Transferrin; D002996:Clomiphene; D003994:Bucladesine; D005340:Fibrinogen; D013974:Thyroxine; D006854:Hydrocortisone