Immunological experimental arthritis in pigs. V. Reaction of the synovial membrane in the pigs non-immunized and immunized with the virus of Aujeszky's disease after the intraarticular administration of the immunological complexes.
Immunized animals were given intraarticular complexes formed in vitro from the autologous serum and virus AD. 7 days after complex administration with excess of the virus, weak inflammatory reactions of the immunological type were noted. After neutral complex administration virulent immunological inflammation of the synovial membrane took place. The histological picture resembled rheumatoid arthritis in the man and the changes obtained after the virus administration to the joints with a high level of antibodies. Administration of complexes and homological serum alone to the joints of the nonimmunized animals caused the occurrence of superficial focuses of fibrinoid necrosis, but there was a lack of cellular reactions.
D000818:Animals; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D006564:Herpesviridae / Q000276:immunology*; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007114:Immunization; D013552:Swine; D013583:Synovial Membrane / Q000276:immunology; D013585:Synovitis / Q000276:immunology / Q000473:pathology
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex