title: [Activity of lactate dehydrogenase and its isofractions in experimental asymptomatic adenovirus infections].
abstract: Experimentally in 147 dog puppies an asymptomatic infection caused by adenovirus of human origin was produced and the process was caused to become manifest by administration of the same virus against the background of the effect of antilymphocyte serum. The activity of LDG in asymptomatic adenovirus infection was found to decrease in the cytoplasmic fraction of hepatocytes and to increase in the blood serum. An increase in the content of the "hepatic" complex of LDG in the blood serum and its decrease in the cytoplasmic fraction of hepatocytes was established indicating disorders in the liver function. It is concluded that asymptomatic adenovirus infection leads to the formation of the state of pre-pathology. Manifestation of the infection enhances the quantitative aspect of the changes.
mesh_terms: D000257:Adenoviridae Infections / Q000097:blood / Q000201:enzymology*; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D004285:Dogs; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis* / Q000097:blood; D008099:Liver / Q000201:enzymology*
chemical_list: D000961:Antilymphocyte Serum; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Aktivnost' laktatdegidrogenazy i ee izofraktsii pri éksperimental'noĭ bessimptomnoĭ adenovirusnoĭ infektsii.