Comparison of behaviors elicited by electrical brain stimulation in dorsal brain stem and hypothalamus of rats.
Four brain-stimulation phenomena elicited from both dorsal brain stem and hypothalamic sites were investigated with the following results:  (a) intracranial self-stimulation rate-intensity functions for dorsal brain stem and hypothalamic sites yielded very high (over 1,000 responses/15 min.) to moderate (201-500 responses/15 min.) response rates; (b) d-amphetamine produced higher response rates than either l-amphetamine or saline at both dorsal brain stem and hypothalamic sites, indicating that noradrenergic dorsal brain stem fibers (or cell bodies) support intracranial self-stimulation; (c) dorsal brain stem and hypothalamic self-stimulation sites reliably produced escape behavior; (d) simultaneous stimulation of dorsal brain stem and hypothalamic sites at subthreshold intensities interacted to produce suprathreshold response rates.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001143:Arousal; D001933:Brain Stem / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000187:drug effects; D003216:Conditioning, Operant; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004924:Escape Reaction; D007031:Hypothalamus / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D007274:Injections, Intraperitoneal; D007536:Isomerism; D008297:Male; D051381:Rats; D011930:Reaction Time; D012640:Seizures / Q000209:etiology; D012653:Self Stimulation
D000316:Adrenergic alpha-Agonists; D000661:Amphetamine; D003913:Dextroamphetamine