Action of p-(4-amidino-phenoxy)-benzaldehyde-p-amidino-phenylhydrazone dihydrochloride on Leishmania donovani infections in the golden hamster.
The chemotherapeutic effect of a new diamidine, HOE 668, the p-(4-amidino-phenoxy)-benzaldehyde-p-amidino-phenylhydrazone dihydrochloride, was compared with that of known anti-leishmanial drugs in golden hamsters infected with Leishmania donovani. The effect of HOE 668 against visceral leishmaniasis proved superior to that of pentamidine isethionate and the pentavalent antimonial drugs, sodium stibogluconate and N-methylglucamine antimoniate. However, HOE 668 can be used only experimentally because of its toxicity. Its very good anti-leishmanial action qualifies HOE 668 as a standard compound in screening tests.
D000578:Amidines / Q000627:therapeutic use*; D000818:Animals; D000965:Antimony / Q000627:therapeutic use; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008536:Meglumine / Q000627:therapeutic use; D008647:Mesocricetus; D010419:Pentamidine / Q000627:therapeutic use
D000578:Amidines; D010419:Pentamidine; C018422:HOE 668; D008536:Meglumine; D000965:Antimony; D000967:Antimony Sodium Gluconate