An adrenocorticotropin analog [ACTH(6-39)] which acts as a potent in vitro adrenocorticotropin antagonist at low calcium concentration and as a weak agonist at high calcium concentration.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D003366:Cosyntropin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D013256:Steroids / Q000096:biosynthesis
D013256:Steroids; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium