Inhalatory infection of mice with influenza A0/PR8 virus. II. Detection of the virus in the blood and extrapulmonary organs.
In the course of experimental aerosol infection of mice with influenza A virus, the latter was regularly detected in the blood, liver, salivary glands, spleen, pancreas, kidneys, heart and irregularly in cervical and mediastinal lymph nodes. The findings of extrapulmonary virus were in direct quantitative relationship to the rate of lung involvement.
D000336:Aerosols; D000367:Age Factors; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001769:Blood / Q000382:microbiology; D003238:Connective Tissue / Q000276:immunology; D004727:Endothelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006321:Heart / Q000382:microbiology; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008482:Mediastinum; D051379:Mice; D008815:Mice, Inbred Strains; D009975:Orthomyxoviridae / Q000276:immunology / Q000302:isolation & purification*; D009976:Orthomyxoviridae Infections / Q000382:microbiology* / Q000635:transmission; D010179:Pancreas / Q000382:microbiology; D012469:Salivary Glands / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D013997:Time Factors
D000336:Aerosols; D000956:Antigens, Viral