Rat tracheal organ culture supports replication of parainfluenza 1 (6/94) virus and promotes 6/94 virus rescue from latently infected human brain cells.
Rat tracheal organ culture (TOC) supported replication of parainfluenza 1 (6/94) virus. Cell-associated and cell-free viruses were found after primary infection of TOC. In contrast to other mammalian systems, rat TOC was capable of maintaining 6/94 virus infectivity after primary infection. Rat TOC may be considered a potential indicator system that could be used to detect virus latent in human tissue.
D000818:Animals; D001921:Brain / Q000382:microbiology; D046508:Culture Techniques; D006801:Humans; D009924:Organ Culture Techniques; D010222:Parainfluenza Virus 1, Human / Q000254:growth & development* / Q000302:isolation & purification; D051381:Rats; D014132:Trachea; D014779:Virus Replication