Properties of mannitol injection (25%) after repeated autoclavings.
The physical and chemical properties of mannitol injection 25% were examined after repeated autoclavings.  The product was found to be stable after five autoclavings of 250 F for 15 minutes each.  No extracts from the rubber closures were found.  It is advised that the product may be repeatedly heated or autoclaved if crystals appear as a result of storage.
D004349:Drug Packaging; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008353:Mannitol / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D013242:Sterilization
D008353:Mannitol