Trichinella spiralis: acceleration and inhibition of cyst calcification in rats.
Daily administration of vitamin D3 (75,000 IU/kg b. wt) for 7 days accelerated Trichinella spiralis cyst calcification in rats with a 14-week-old infection. When disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered (50 mg/kg b. wt) from 2 days before until 2 days after vitamin D3 treatment, cyst calcification was inhibited. Thus, the ability to inhibit E. spiralis calcification has demonstrated for the first time.
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000469:parasitology / Q000517:prevention & control; D002762:Cholecalciferol / Q000494:pharmacology; D012968:Etidronic Acid / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D008297:Male; D051381:Rats; D014234:Trichinella / Q000187:drug effects*; D014235:Trichinellosis / Q000150:complications / Q000469:parasitology* / Q000473:pathology
D002762:Cholecalciferol; D012968:Etidronic Acid