title: Prochlorperazine in childhood: side-effects.
abstract: The side-effects of prochlorperazine (CompazineR StemetilR) were traced in thirty-six children up to the age of sixteen years and compared with those collected from literature. These side-effects appeared to be predominantly neurological and were independent of the dosage. Impaired consciousness, dyskinesia, pyramidal signs and hypertonus were the main neurological manifestations. Dyskinesia was the most frequent sign. These side-effects disappear spontaneously after discontinuation of the drug. Instant cure can be acquired by intra-muscular administration of orphenadrine (DisipalR).
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003244:Consciousness Disorders / Q000139:chemically induced; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009122:Muscle Hypertonia / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011346:Prochlorperazine / Q000008:administration & dosage / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D011712:Pyramidal Tracts
chemical_list: D011346:Prochlorperazine