[Significance of beta-adrenoreception in realizing the glycogenolytic and lipolytic effects of excess thyroid hormones].
In experiments on rats the chronic administration of beta-adrenoblocker obsidan (propranolol) in doses blocking the glycogenolytic and lipolytic effects of exogenous epinephrine does not prevent a decrease in the liver and heart glycogen level and an increase of free fatty acids (FFA) in the serum as well as of lipolytic activity of adipose tissue in vitro, which are produced by high doses of thyroxine.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006003:Glycogen / Q000378:metabolism*; D008066:Lipolysis / Q000187:drug effects*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011433:Propranolol / Q000008:administration & dosage; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013963:Thyroid Hormones / Q000494:pharmacology*; D013974:Thyroxine / Q000008:administration & dosage
D005230:Fatty Acids, Nonesterified; D008112:Liver Glycogen; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D013963:Thyroid Hormones; D006003:Glycogen; D011433:Propranolol; D013974:Thyroxine; D004837:Epinephrine
O znachenii beta-adrenoretseptsii v realizatsii glikogenoliticheskogo i lipoliticheskogo éffektov izbytka tireoidnykh gormonov.