The stability constants of some metal ion complexes of 3',5'-cyclic AMP.
The stability constants of complexes of 3', 5'-cyclic AMP with Mg2+, Ca2+, Mn2+, Ni2+ and Co2+ were estimated at 30 degrees C in solutions of ionic strength about 0.15 containing about 130 mM K+ or tetramethylammonium ions. Values between 13 and 22 M-1 were obtained, indicating that only about 2% of cyclic AMP is present as metal complexes in vivo, but that at commonly used in vitro concentrations of 10 mM bivalent metal ions, 10--20% of cyclic AMP is present as metal complexes. The possible significance of these metal complexes, for example as competitive inhibitors, is discussed.
D002118:Calcium; D002413:Cations, Divalent; D003035:Cobalt; D000242:Cyclic AMP; D004355:Drug Stability; D007475:Ion Exchange Resins; D008274:Magnesium; D008345:Manganese; D009532:Nickel; D009994:Osmolar Concentration
D002413:Cations, Divalent; D007475:Ion Exchange Resins; D003035:Cobalt; D008345:Manganese; D009532:Nickel; D000242:Cyclic AMP; D008274:Magnesium; D002118:Calcium