Cyclic adenosine 3', 5'-monophosphate and the mechanism of action of three common anti-inflammatory drugs.
1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3', 5'-monophosphate (cyclic AMP) concentration in leucocytes during a crystal-induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti-inflammatory drug.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology; D000242:Cyclic AMP / Q000097:blood*; D003907:Dexamethasone / Q000494:pharmacology; D011756:Diphosphates / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010998:Pleurisy / Q000139:chemically induced / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011756:Diphosphates; D003907:Dexamethasone; D000242:Cyclic AMP; D003078:Colchicine; D007213:Indomethacin