[The treatment of headaches: an open randomized comparative therapeutic study (author's transl)].
An open, randomized clinical trial was carried out to compare the therapeutic efficacy of two products in the treatment of headaches. A total of 65 patients were prescribed tiapride and a similar number were given dimetotiazine (neuroleptic indicated in migraine and headache). Tiapride was prescribed as 3 tablets a day for the first 24 hours, followed by 1/2 a tablet three times daily. Excellent or good results (improvement of 60% or more), were obtained in 49 patients (75%). Results after dimetotiazine, at the recommended dosage of 2 capsules during the first 24 hours followed by 1 capsule at night, gave 30 excellent or good results (46%). There is a highly significant difference (p less than 0,01) in favour of tiapride. Both products were well-tolerated.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001549:Benzamides / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006261:Headache / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D012737:Sex Factors; D013976:Tiapamil Hydrochloride / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D001549:Benzamides; D010640:Phenothiazines; D013976:Tiapamil Hydrochloride
Essai thérapeutique comparatif randomisé ouvert dans les céphalées.