Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat.
The authors studied various drugs with anti-inflammatory or antirheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. The following compounds were studies according to various methods of treatment: indomethacin, phenylbutazone, cyclophosphamide, desonide, chloroquine, levamisole, D-penicillamine and sodium aurothiopropanol sulphonate. The action on the volume of pleural exudate and on cell events depended on the compounds and the conditions of treatment. Only gold salt produced no reduction in the pleural volume under all methods of treatment. All the compounds studied produced various degrees of significant modifications at the level of the cell events.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001886:Bordetella pertussis / Q000276:immunology*; D002738:Chloroquine / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D003898:Desonide / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D010998:Pleurisy / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*; D012216:Rheumatic Diseases / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D007978:Levamisole; D002738:Chloroquine; D003520:Cyclophosphamide; D010653:Phenylbutazone; D010396:Penicillamine; D003898:Desonide; D007213:Indomethacin