title: Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension.
abstract: Studies were carried out in 69 patients with essential hypertension to examine the relationship between changes in plasma renin activity (PRA) and arterial pressure (BP) in response to a beta-adrenergic blocking agent, propranolol. PRA had no consistent relationship with BP during treatment, either in patients receiving propranolol alone (r = 0.12) or in those receiving a combination of diuretics and propranolol (r = 0.18). Furthermore, long-term beta-adrenergic blockade failed to inhibit increases of PRA induced by diuretics or rapid sodium depletion. These results indicate that (1) beta-adrenergic blockade can reduce BP by mechanisms other than PRA suppression; and (2) the beta-adrenergic nervous system is important, but not essential, for renin release.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002712:Chlorides / Q000097:blood; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000652:urine; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood / Q000652:urine; D014508:Urea / Q000097:blood; D014882:Water-Electrolyte Balance
chemical_list: D000319:Adrenergic beta-Antagonists; D001639:Bicarbonates; D002712:Chlorides; D004232:Diuretics; D014508:Urea; D012964:Sodium; D011433:Propranolol; D003404:Creatinine; D012083:Renin; D011188:Potassium