title: Spasmolytic activity of two synthetic anilide local anaesthetics.
abstract: Two basic anilides EA-7 and EA-8 were investigated for their antispasmodic activity against a variety of spasmogens on different tissues from different species of animals and comparison was made with lignocaine. EA-8 was found to be the most potent in this respect, followed by EA-7 and lignocaine. The antispasmodic potency does not correspond to their local anaesthetic potency. This suggests a direct depressant effect on tissues.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000779:Anesthetics, Local / Q000494:pharmacology*; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001464:Barium / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D004837:Epinephrine / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D011817:Rabbits; D051381:Rats; D014132:Trachea / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D000813:Anilides; D006634:Histamine H1 Antagonists; D001464:Barium; D008012:Lidocaine; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine