Erythrocyte membrane protein kinase and adenylate cyclase in Duchenne muscular dystrophy.
In freshly prepared erythrocyte membranes from normal individuals and patients with Duchenne progressive muscular dystrophy the endogenous protein kinase and the cAMP stimulated phosphorylation was identical for the 3 main32P proteins including spectrin (protein band II). Another enzyme, adenylate cyclase, was found unchanged. Altered protein kinase and adenylate cyclase have been reported in this disorder. We have no explanation for these discrepancies.
D000262:Adenylyl Cyclases / Q000097:blood*; D000242:Cyclic AMP / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D008565:Membrane Proteins / Q000097:blood; D009136:Muscular Dystrophies / Q000201:enzymology*; D010750:Phosphoproteins / Q000097:blood; D010766:Phosphorylation; D011494:Protein Kinases / Q000097:blood*
D008565:Membrane Proteins; D010750:Phosphoproteins; D000242:Cyclic AMP; D011494:Protein Kinases; D000262:Adenylyl Cyclases