Prostaglandin-like activity in the aqueous humor following alkali burns.
Following application of 20 mul of 2 N sodium hydroxide to the rabbit cornea, the prostaglandin-like activity in the aqueous humor increased from undetectable levels to around 30 ng, per milliliter, a level which was sustained for up to 24 hours. This increase correlated with the previously reported sustained elevation of intraocular pressure following a 20 mul alkali burn. Pretreatment with aspirin or indomethacin virtually abolished the increase in intraocular pressure and elevation of prostaglandin-like activity in the aqueous humor following a 20 mul burn. Marked ocular hypotension following 50 mul and 100 mul sodium hydroxide burns correlated with very low prostaglandin-like activity in the aqueous humor. The low prostaglandin-like activity probably resulted from alkaline hydrolysis of aqueous prostaglandins and massive cellular death in iris and ciliary body tissues.
D000468:Alkalies; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis*; D001241:Aspirin / Q000494:pharmacology; D001794:Blood Pressure; D002057:Burns, Chemical / Q000209:etiology* / Q000503:physiopathology; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007213:Indomethacin / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects; D011453:Prostaglandins / Q000032:analysis*; D011817:Rabbits; D012972:Sodium Hydroxide; D013997:Time Factors
D000468:Alkalies; D011453:Prostaglandins; D012972:Sodium Hydroxide; D001241:Aspirin; D007213:Indomethacin