[Isoenzymes of alaninarylamidase and gamma-glutamyl-transpeptidase in intrahepatic and extra-hepatic cholostasis (author's transl)].
In 43 patients with intrahepatic and extrahepatic cholostasis alaninarylamidase (AAP) and gamma-glutamyl-transpeptidase (GGTP) in serum were measured and the isoenzymes were determined in agar-gelectrophoresis. The isoenzyme-fraction 2 (in alpha-2-globulin running) of AAP was significant higher in the group of extra-hepatic cholostasis than in the group of intrahepatic cholostasis. Practical importance of the findings is diminished by large variation coefficients of the results. The importance of isoenzymes of GGTP for differentiation of cholostasis is not large. A special low quotient of two anodic isoenzymes of GGTP (fraction running with alpha-1-globulin  to fraction running with beta-globulin) indicates probably a neoplasm of pancreatobiliary tract if there is a high level of total serum-GGTP.
D000409:Alanine; D001650:Bile Duct Neoplasms / Q000201:enzymology; D002779:Cholestasis / Q000201:enzymology*; D003937:Diagnosis, Differential; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008113:Liver Neoplasms / Q000201:enzymology; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000201:enzymology; D010447:Peptide Hydrolases / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood*
D007527:Isoenzymes; D005723:gamma-Glutamyltransferase; D010447:Peptide Hydrolases; D000409:Alanine
Isoenzyme von Alaninarylamidase (AAP) und Gamma-Glutamyl-Transpeptidase (GGTP) bei intra- und extraheptischer Cholostase