Differential susceptibility of peripheral nerves of the hen to triorthocresyl phosphate and to trauma.
The nerve fibres of largest diameter and of greatest length are considered to be the most vulnerable to triorthocresyl phosphate (TOCP). In this study, the differential vulnerability of the particular sciatic nerve branches was determined in the course of TOCP neuropathy and of Wallerian degeneration. The branch innervating the lateral gastrocnemius muscle, made up predominantly of large-diameter fibres, proved most susceptible to TOCP. By contrast, after proximal sciatic-nerve transection, degeneration commenced in the lateral nerve of the third digit, containing long nerve fibres of small diameter.
D000818:Animals; D002645:Chickens; D003408:Cresols / Q000633:toxicity*; D005260:Female; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000473:pathology; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D013997:Time Factors; D014317:Tritolyl Phosphates / Q000633:toxicity*
D003408:Cresols; D014317:Tritolyl Phosphates