Methylmercaptopurine ribonucleoside toxicity in human fibroblasts: inhibition of phosphoribosylpyrophosphate synthetase as well as amidophosphoribosyltransferase.
D000582:Amidophosphoribosyltransferase / Q000037:antagonists & inhibitors*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives*; D007700:Kinetics; D008778:Methylthioinosine / Q000494:pharmacology*; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D012268:Ribose-Phosphate Pyrophosphokinase / Q000037:antagonists & inhibitors*; D012867:Skin / Q000201:enzymology
D008778:Methylthioinosine; D007288:Inosine; D010430:Pentosyltransferases; D000582:Amidophosphoribosyltransferase; D010770:Phosphotransferases; D012268:Ribose-Phosphate Pyrophosphokinase