Central effects of octopamine administered into the lateral ventricle of rats.
Central effects of octopamine administered into the lateral ventricle of rats. Acta physiol. pol., 1979, 30 (4): 445--453. Octopamine (100, 250 and 500 micrograms/rat i.v.c.) exerted a stimulating effect on the central nervous system in rats, which was evidenced by increased spontaneous and basal motor activity, increased exploratory activity in the free-field test, and also increased motor activity in reserpinised rats pretreated with alpha-MT or nialamide. Octopamine decreased the body temperature and prolonged the duration of hexobarbital-induced sleep, and increased amphetamine-induced hyperactivity. Locomotor agitation after octopamine injection was inhibited by phenoxybenzamine and yohimbine in a dose of 10 mg/kg i.p.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009655:Octopamine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors
D011956:Receptors, Cell Surface; D009655:Octopamine; D012110:Reserpine