Pharmacodynamics of stannous chelates administered with 99mTc-labeled chelates.
The pharmacodynamics of several tin compounds were studied in healthy rabbits, rabbits with myocardial infarcts, and isolated myocardial tissue. The results showed that tin chelates of pyrophosphate, HEDP, DTPA, and glucoheptonate are very unstable in vivo, giving rise to free stannous ions. These ions localize mainly in bone, with the rest being primarily excreted in the urine. They also concentrate more in infarcted than in normal myocardium; there they enter the mitochondria. The supernatant of homogenates contains bound and free fractions, demonstrating a subcellular distribution pattern similar to that of calcium ions. Tin chelates have different pharmacodynamics from the corresponding 99mTc chelates.
D000818:Animals; D001345:Autoradiography; D002614:Chelating Agents / Q000378:metabolism / Q000494:pharmacology*; D011756:Diphosphates / Q000378:metabolism / Q000494:pharmacology; D005269:Femur / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000652:urine; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D011817:Rabbits; D011868:Radioisotopes; D004113:Succimer / Q000378:metabolism / Q000494:pharmacology; D013667:Technetium; D013997:Time Factors; D014001:Tin; D014018:Tissue Distribution
D002614:Chelating Agents; D011756:Diphosphates; D011868:Radioisotopes; D013667:Technetium; D014001:Tin; D004113:Succimer