Effect of estrogens on the myeloperoxidase-mediated antimicrobial system.
Estradiol 17 beta prevented the fall in the microbicidal activity of the myeloperoxidase-H2O2-halide system induced by high H2O2 concentrations. In contrast, when the H2O2 (and halide) concentrations were low the myeloperoxidase-H2O2-halide antimicrobial system was inhibited by estradiol. These properties of estradiol 17 beta were shared by estradiol 17 alpha, estrone, estriol, ethinyl estradiol, and phenol, but not by estradiol-3-benzoate, testosterone, progesterone, hydroxyprogesterone, cortisone, hydrocortisone, or deoxycorticosterone.
D001965:Bromides / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007454:Iodides / Q000494:pharmacology; D009195:Peroxidase / Q000494:pharmacology*; D010544:Peroxidases / Q000494:pharmacology*
D001965:Bromides; D002712:Chlorides; D004967:Estrogens; D007454:Iodides; D004958:Estradiol; D006861:Hydrogen Peroxide; D010544:Peroxidases; D009195:Peroxidase