[Hemodynamics in patients suffering from hyperkinetic cardiac syndromes and in normal persons under psychological stress before and after treatment with propranolol (author's transl)].
In patients with hyperkinetic heart syndrome we found at rest a higher heart rate, a higher stroke volume and a higher cardiac output than in normal volunteers. Therefore blood pressure is high although peripheral resistance is lower than in normals. Similar circulatory differences were found under conditions of mental stress. After beta-adrenergic blockade with 15 mg Propranolol heart rate and cardiac output decrease, whereas peripheral resistance increases. Mean blood pressure thus remains unchanged. Even after beta-adrenergic blockade circulatory differences between normals and patients with hyperkinetic heart syndrome are seen. The possible causes of these differences are discussed.
D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002306:Cardiac Volume / Q000187:drug effects; D003864:Depression, Chemical; D006331:Heart Diseases / Q000188:drug therapy / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006948:Hyperkinesis; D006973:Hypertension / Q000503:physiopathology; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013315:Stress, Psychological / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Hämodynamische Veränderungen bei Patienten mit hyperkinetischem Herzsyndrom und bei Normalpersonen unter psychischem Stress vor und nach Beta Rezeptoren-Blockade mit Propranolol.