[Effects of fasting and of ACTH on renal compensatory hypertrophy in the 48 hour uninephrectomized rat].
Renal compensatory hypertrophy (R.C.H.) is determined 48 h. after uninephrectomy in fed and fasting rats having free access to a NaCl solution. ACTH (18 gamma/100 g BW/d/2d) enhances R.C.H. in the fed animals. R.C.H. is severely impaired by food deprivation and the remaining kidney looses weight; a normal kidney weight can be maintained if the fasted, uninephrectomized rat is treated with ACTH. These experiments suggest that the stimulation of the adrenal cortex by ACTH has a renotrophic effect. This action may be related to the elevation of blood glucose or/and to the fall of the concentration of plasma K+.
D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D005215:Fasting; D005260:Female; D006984:Hypertrophy; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D009392:Nephrectomy; D051381:Rats
D000324:Adrenocorticotropic Hormone
Effets du jeûne et de l'ACTH sur l'hypertrophie rénale compensatrice chez le rat uninéphrectomisé depuis 48 heures.