Antiphosphaturic action of 25 (OH) vitamin D3 in experimental Fanconi syndrome.
Renal handling of phosphorus was studied in the following groups of parathyroidectomized rats with maleate-induced Fanconi syndrome: 1) 6 rats receiving intravenous parathyroid hormone, 2) 6 rats receiving intravenous dibutyryl cyclic AMP (DBcAMP), 3) 6 rats undergoing volume expansion with saline, 4) 12 rats receiving intravenous 25 (OH)vitamin D3, 5) 12 rats with acute hypercalcemia induced by intravenous CaCl2, 6) 6 rats with phosphate deprivation, and 7) 6 rats receiving intravenous calcitonin. Parathyroid hormone and calcitonin failed to increase the urinary excretion of both cAMP and phosphorus. Likewise, DBcAMP failed to increase the urinary excretion of phosphorus. Extracellular volume expansion and hypercalcemia (serum calcium 12.9 +/- 0.7 mg/100 ml) did not alter the tubular reabsorption of phosphorus. In phosphate-deprived animals, the fractional excretion 0.16 +/- 0.05 (mean +/- SE) was lower than that in the control animals (maleate-treated without phosphate depletion), 0.46 +/- 0.04 (P less than 0.001). 25 (OH)vitamin D3 decreased the fractional excretion of phosphorus from 0.39 +/- 0.03 in the control (maleate-treated not receiving 25 (OH)vitamin D3) to 0.23 +/- 0.02 (P less than 0.001) in the experimental animals. The present study demonstrated an antiphosphaturic effect of 25(OH)vitamin D3 in experimental Fanconi syndrome; the mechanism of this action is not well understood.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002762:Cholecalciferol / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D005198:Fanconi Syndrome / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008293:Malates / Q000494:pharmacology; D010281:Parathyroid Hormone / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats
D008293:Malates; D010281:Parathyroid Hormone; D010710:Phosphates; D002762:Cholecalciferol; D010758:Phosphorus; D002116:Calcitonin; D000242:Cyclic AMP; D002118:Calcium