Prostacyclin (PGI2) in pregnant human uterus.
Prostacyclin lowers the tonus and reduces the spontaneous motility of isolated pregnant human myometrium. This effect seems to be related to coclic-AMP accumulation, since PGI2 increases the formation of this cyclic nucleotide in incubated minces of pregnant and non-pregnant uterus. The ability of this tissue to generate a labile substance which inhibits platelets aggregation, has been demonstrated and discussed.
D000328:Adult; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D011453:Prostaglandins; D011460:Prostaglandins F; D011464:Epoprostenol; D000242:Cyclic AMP