[Interactions of low density lipoproteins with glycosaminoglycans and foam cells within the atherosclerotic aorta (author's transl)].
Very low and low density lipoproteins (VLDL and LDL) isolated from aorta's intima in salt solution were predominantly, associated in complex with glycosaminoglycans (GAG): hyaluronic acid, chondroitinsulfate A(C), heparin. Heparin was detected mainly in complex, isolated from fibrosis plaque. Studying of interaction between LDL and foam cells showed that cells in situ as far as under their incubation in medium with llow LDL concentration primarily accumulated lipid of lipoprotein particles. Incubation foam cells under increased concentration of lipoprotein in medium led to greater entry of radioactivity into the cells. However, there was less tendency for primarily lipid accumulation. Increase of LDL concentration correlated with larger cell's CO2 production. GAG prevented this effect of LDL. Besides LDL uptake was decreased in this condition too. It is possible that GAG effect lipoprotein properties and in such a way the character of their interaction with cells.
D000328:Adult; D000368:Aged; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism*; D001345:Autoradiography; D004347:Drug Interactions; D005487:Foam Cells / Q000378:metabolism*; D005609:Free Radicals; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D008854:Microscopy, Electron; D008875:Middle Aged; D011817:Rabbits
D005609:Free Radicals; D006025:Glycosaminoglycans; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL
Die Wechselwirkung von low-density-Lipoprotein mit Glukosaminoglykanen und Schaumzellen der atherosklerotischen Aorta.