[Quantitative model of human erythrocyte glycolysis. Relationship between erythrocyte energy metabolism and Na+, K+-ATPase activity].
The influence of the changes of the transport Na+, K+-ATPase activity on the human red blood cell (RBC) glycolysis was studied. Two different types of energetic regulation were found out under the strophanthin inhibition. A decrease of ATP comsumption results in a drop of glucose consumption and lactate production in the first type regulation of RBC. In the second type regulation of RBC the glucose consumption does not change after ATPase inhibition and the excess metabolic flux is directed through the hexosemonophosphate shunt. In both cases the resulting decrease of ATP production leads to the ATP level stabilization. An increase of potassium ions concentration in the external medium does not influence the RBC glycolysis. The valinomycin added increases the glucose consumption and the lactate production. The cell volume decreases under the effect of valinomycin.
D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D011188:Potassium / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013328:Strophanthins / Q000494:pharmacology; D014634:Valinomycin / Q000494:pharmacology
D013328:Strophanthins; D014634:Valinomycin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Kiolichestvennaia model' glikoliza éritrotsita cheloveka. Zavisimost' énergeticheskogo metabolizm éritrotsitov ot aktivnosti Na+, K+-ATFazy.