[Effect of sustained release alprenolol in hypertension uncontrolled by chlorothiazide and dihydralazine. Study in double blind (author's transl)].
In 20 hypertensive patients with functioning renal graft, sustained release alprenolol or placebo was given orally for 2 months, in combination with chlorothiazide and dihydralazine, after previous failure of these 2 last drugs. Blood pressure was normalized with alprenolol during the length of the study, but is was not with placebo. Mean plasma renine level decreased of 45 p. cent.
D000284:Administration, Oral; D000328:Adult; D000526:Alprenolol / Q000008:administration & dosage* / Q000627:therapeutic use; D002740:Chlorothiazide / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004078:Dihydralazine / Q000627:therapeutic use; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D016030:Kidney Transplantation; D008875:Middle Aged; D010919:Placebos; D012083:Renin / Q000097:blood; D014184:Transplantation, Homologous
D003692:Delayed-Action Preparations; D010919:Placebos; D002740:Chlorothiazide; D000526:Alprenolol; D012083:Renin; D004078:Dihydralazine
Effet de l'alprénolol a longue durée d'action sur les hypertensions artérielles mal contrôlées par l'association thiazidique-dihydralazine. Etude en double aveugle.