Effect of ornithine alpha oxoglutarate on brain metabolism in patients with chronic liver disease.
Patients with chronic liver disease, yet without severe encephalopathy, were found to show evidence of increased brain utilization of glucose. The changes were abolished after an intravenous infusion of 15 g ornithine alpha oxoglutarate, given over a period of 15 minutes. The possible implications of these observations are discussed.
D000328:Adult; D000368:Aged; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002540:Cerebral Cortex / Q000098:blood supply; D002908:Chronic Disease; D004569:Electroencephalography; D005260:Female; D005947:Glucose / Q000378:metabolism; D006501:Hepatic Encephalopathy / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009952:Ornithine / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
D000600:Amino Acids, Dicarboxylic; D001786:Blood Glucose; D007656:Ketoglutaric Acids; D007773:Lactates; D002245:Carbon Dioxide; D009952:Ornithine; D005947:Glucose; D010100:Oxygen