Correlation of immunogenicity with suppression of lymphocyte adenosine 3',5'-monophosphate-dependent protein kinase.
Cyclic-AMP-dependent protein kinase activity was depressed in whole spleen as well as in isolated splenic lymphocytes from 3-methylcholanthrene (MCA), R3230 AdCa mammary adenocarcinoma, N-hydroxy-2-acetylaminofluorene, and 4-dimethylaminoazobenzene (DMAAB) tumor-bearing Fischer rats as compared to control animals. The magnitude of depression increased with the immunogenicity of the tumor. The depressed enzyme activity was the result of a reduced Vmax for adenosine 3',5'-monophosphate (cAMP)-stimulated histone phosphorylation.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D004789:Enzyme Activation; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000276:immunology; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000201:enzymology* / Q000276:immunology
D000242:Cyclic AMP; D011494:Protein Kinases