Activated forms of oxygen in the metabolism of xenobiotics catalyzed by cytochrome P-450.
The Cu(Lys)2 complex is shown to be an effective inhibitor of the oxidation of 3,4-benzpyrene and aniline in microsomes. Apparently, this is due to the dismutation of superoxide radicals involved in the metabolism of these compounds. Possible interactions between Cu(Lys)2 and model membranes have been studied using spin probes. A model has been suggested according to which Cu(Lys)2 "builds" in the membrane hydrocarbon regions.
D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D002248:Carbon Monoxide; D003300:Copper / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D007700:Kinetics; D008239:Lysine / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013053:Spectrophotometry
D000814:Aniline Compounds; D001580:Benzopyrenes; D003300:Copper; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D009251:NADPH-Ferrihemoprotein Reductase; D008239:Lysine