title: [Adrenal cortex and vitamin PP. The effect of corticosteroids on the NAD level in the rat liver after the administration of excess nicotinic acid or nicotinamide].
abstract: The NAD content in the liver was experimentally studied in intact, adrenalectomized rats and those given hydrocortisone following nicotinic acid and nicotinamide administration. The NAD concentration in the liver rose linearly and equally during the first 4 experimental hours after the nicotinamide administration (200 mg/kg). A conclusion was drawn that in administration of exogenous precursors the coenzyme biosynthesis did not depend on the initial hormonal background.
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000315:Adrenalectomy; D000818:Animals; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000008:administration & dosage* / Q000378:metabolism*; D009539:Nicotinic Acids / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D009539:Nicotinic Acids; D009243:NAD; D009536:Niacinamide
vernacular_title: Kora nadpochechnikov i vitamin PP. Vliianie kortikosteroidov na uroven' NAD v pecheni krys posle vvedeniia izbytka nikotinovoĭ kisloty ili nikotinamida.