title: [Spectral-luminescent study of pH-dependent conformational changes in fibrinogen].
abstract: Results are presented of measurements of fluorescence parameters of fibrinogen at pH values of 2-12. It is stated that the stability zone of native conformation of fibrinogen molecule lies in the pH range of 5,5-8,5. In an acid medium the fibrinogen molecule twice (in the pH range of 5--3 and 3--2) undergoes structural rearrangement. In an alkali medium the structural rearrangement of fibrinogen is observed at pH greater than 9,5.
mesh_terms: D000817:Anilino Naphthalenesulfonates; D005340:Fibrinogen; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D013050:Spectrometry, Fluorescence
chemical_list: D000817:Anilino Naphthalenesulfonates; D005340:Fibrinogen
vernacular_title: Spektral'no-liuminestsentnoe issledovanie pH-zavisimykh konformatsionnykh izmeneniĭ fibrinogena