Sepsis, resuscitated hemorrhagic shock and "shock lung:" An experimental correlation.
Dogs were submitted to hermorrhagic shock, resuscitated shock and resuscitated shock plus a pulmonary bacterial insult. Pulmonary familure was absent in dogs submitted only to shock or to shock and its resuscitation. The addition of usually sub-lethal amounts of micro-organisms to the shock-resuscitated lung caused rapid death from pulmonary failure. Pulmonary failure was demonstrated by increased lung weight, hypoxemia, decreased compliance and a hemorrhagic destruction of lung tissue. These findings strongly support recent concepts of an infective genesis of "shock lung" in man.
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D004195:Disease Models, Animal; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000209:etiology; D008168:Lung / Q000473:pathology; D008170:Lung Compliance; D011552:Pseudomonas Infections / Q000150:complications / Q000503:physiopathology; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000150:complications*; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000401:mortality; D013990:Tidal Volume; D014655:Vascular Resistance; D014692:Ventilation-Perfusion Ratio