Effects of macrophages in resistance to murine cytomegalovirus infection.
In a preliminary experiment, the protective effects of peritoneal macrophages was shown by transferring macrophages from adult mice to newborn and to 7 and 14 days old mice. It was demonstrated that such transplantation protect suckling mice from intraperitoneal infection with MCMV by reducing the mortality rate from 100% to 27%.
D000818:Animals; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000517:prevention & control; D008264:Macrophages / Q000276:immunology* / Q000637:transplantation; D051379:Mice; D010532:Peritoneal Diseases / Q000517:prevention & control; D014184:Transplantation, Homologous