title: A different genetic code in human mitochondria.
abstract: Comparison of the human mitochrondial DNA sequence of the cytochrome oxidase subunit II gene and the sequence of the corresponding beef heart protein shows that UGA is used as a tryptophan codon and not as a termination codon and suggests that AUA may be a methionine and not an isoleucine codon. The cytochrome oxidase II gene is contiguous at its 5' end with a tRNAAsp gene and there are only 25 bases at its 3' end before a tRNALys gene. These tRNA'S are different from all other known tRNA sequences.
mesh_terms: D001224:Aspartic Acid / Q000235:genetics; D001483:Base Sequence; D003062:Codon; D004272:DNA, Mitochondrial / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics*; D005796:Genes; D005815:Genetic Code; D006801:Humans; D007532:Isoleucine / Q000235:genetics; D008239:Lysine / Q000235:genetics; D008715:Methionine / Q000235:genetics; D012343:RNA, Transfer / Q000235:genetics; D014364:Tryptophan / Q000235:genetics
chemical_list: D003062:Codon; D004272:DNA, Mitochondrial; D007532:Isoleucine; D001224:Aspartic Acid; D014364:Tryptophan; D012343:RNA, Transfer; D008715:Methionine; D003576:Electron Transport Complex IV; D008239:Lysine