Effect of gold on the immune response of mice.
Separate concurrent injection of organic gold compounds and antigen into mice resulted in immunoenhancement that could be measured by direct and indirect plaque-forming cells, rosette-forming cells, and serum antibody assays. Kinetics of the immune response showed variable effects through day 9 of the experiment. Studies with British anti-lewisite, a gold antagonist, showed that the gold must stay in the system 1 day to obtain immunoenhancement.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens; D006051:Aurothioglucose / Q000008:administration & dosage; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006046:Gold / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006386:Hemagglutination Tests; D006460:Hemolysin Proteins / Q000032:analysis; D006461:Hemolysis; D006462:Hemolytic Plaque Technique; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular / Q000187:drug effects*; D007273:Injections, Intramuscular; D051379:Mice; D008815:Mice, Inbred Strains; D011135:Polysaccharides, Bacterial; D012756:Sheep / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology; D013870:Thiomalates / Q000008:administration & dosage
D000941:Antigens; D006460:Hemolysin Proteins; D011135:Polysaccharides, Bacterial; D013870:Thiomalates; D006051:Aurothioglucose; D006046:Gold; D003165:Complement System Proteins