Activation of histidine decarboxylase by H2-receptor blockade: mechanism of action.
1 Treatment with histamine H2-receptor antagonists, which inhibit basal acid secretion was found to activate rat stomach histidine decarboxylase. At the same time the serum gastrin concentration was greatly increased. 2 In antrectomized rats neither the enzyme activity nor the serum gastrin concentration was affected by the treatment. 3 In analogy with previous observations on other inhibitors of acid secretion we suggest that the H2-receptor antagonists stimulate gastrin release through their effect on acid secretion and that the raised serum gastrin level is responsible for the enzyme activation.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000502:physiology; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006639:Histidine; D008297:Male; D051381:Rats; D011955:Receptors, Drug; D013270:Stomach / Q000201:enzymology*
D005755:Gastrins; D006634:Histamine H1 Antagonists; D011955:Receptors, Drug; D006639:Histidine; D006632:Histamine; D002262:Carboxy-Lyases