title: Abnormal intrafusal muscle fibres in myotonic dystrophy: a study using serial sections.
abstract: Studies of the extent and complexity of intrafusal muscle fibre splitting in myotonic dystrophy have been carried out in three spindles obtained at muscle biopsy, and in nine spindles found in the lumbrical muscle of a case that came to necropsy. It is suggested that splitting, due to mechanical stresses, leads to a regenerative response in the separated fragments.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009470:Muscle Spindles / Q000201:enzymology / Q000648:ultrastructure*; D009132:Muscles / Q000473:pathology*; D009210:Myofibrils / Q000648:ultrastructure; D009223:Myotonic Dystrophy / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D012038:Regeneration; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure; D013577:Syndrome
chemical_list: D009247:NADH, NADPH Oxidoreductases; D000251:Adenosine Triphosphatases