Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
Patients with tardive dyskinesia showed no significant difference in CSF HVA when compared with groups of schizophrenic or depressives. CSF cAMP in the tardive dyskinesia group was significantly lower when compared to schizophrenics but not depressives. These results do not support a dopamine-receptor supersensitivity hypothesis in permanent tardive dyskinesia.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D000242:Cyclic AMP / Q000097:blood; D003863:Depression / Q000150:complications; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D011339:Probenecid / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications
D011954:Receptors, Dopamine; D006897:Hydroxyindoleacetic Acid; D000242:Cyclic AMP; D011339:Probenecid; D006719:Homovanillic Acid