Effects of thyrotoxicosis on mitochondrial enzymes of rat soleus.
Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T3 + T4 treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerole-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T3 + T4 treated animals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers.
D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006980:Hyperthyroidism / Q000201:enzymology*; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D013974:Thyroxine