Sodium transport inhibitor from bovine hypothalamus.
A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder, and directly inhibits renal Na+,K+-ATPase. This substance thus possesses the putative characteristics of a natriuretic factor of hypothalamic origin.
D000818:Animals; D001001:Anura; D001667:Binding, Competitive; D002417:Cattle; D007028:Hypothalamic Hormones / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D007668:Kidney / Q000201:enzymology; D008970:Molecular Weight; D009318:Natriuresis; D010042:Ouabain / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D001743:Urinary Bladder / Q000378:metabolism
D007028:Hypothalamic Hormones; D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase