Polyphosphorylated glycerolipids mimic adrenocorticotropin-induced stimulation of mitochondrial pregnenolone-synthesis.
As with adrenocorticotropin pretreatment in vivo, addition of cardiolipin in vitro enhances adrenal mitochondrial pregnenolone synthesis and apparent binding of cholesterol to cytochrome P-450scc. These effects are relatively specific for glycerolipids containing two or more phosphate radicals in the polar head group, and changes in such phospholipids or comparably acting substances may play a role in mediating adrenocorticotropin- or other hormone-induced effects on membrane-associated enzymes.
D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002308:Cardiolipins / Q000494:pharmacology*; D002784:Cholesterol / Q000494:pharmacology; D066298:In Vitro Techniques; D008928:Mitochondria / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000494:pharmacology; D010715:Phosphatidylglycerols / Q000494:pharmacology; D011284:Pregnenolone / Q000096:biosynthesis*; D051381:Rats
D002308:Cardiolipins; D010712:Phosphatidic Acids; D010715:Phosphatidylglycerols; D011284:Pregnenolone; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol