[Regulation of Na, K-ATPase activity in the rat brain by noradrenaline].
Effect of noradrenaline on activity of Na, K-ATPase from heavy microsomes of rat brain was studied in vitro; the effect of noradrenaline was shown to be dose dependent. The maximal activation of the enzyme was observed at 5.10(-5) M concentration of the catecholamine; an increase of its concentration above 5.10(-4) M inhibited Na, K-ATPase. beta-Adrenolytic drug propranolol /1.10(-5) M/ did not affect the noradrenaline action. At the same time, an alpha-adrenolytic drug phentholamine /1.10(-5) M/ decreased down to zero the activating effect of the catecholamine, but did not affect the inhibitory effect of noradrenaline at high concentrations /1.10(-3) M/. Effects of selective alpha-adrenomimetic compound phenylephrine were also studied. The data obtained suggest that the activating effect of noradrenaline on Na, K-ATPase from rat brain is mediated through alpha-adrenoreceptors.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000201:enzymology; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology; D013696:Temperature
D011942:Receptors, Adrenergic, alpha; D013566:Sympathomimetics; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D009638:Norepinephrine
Reguliatsiia aktivnosti Na, K-ATF-azy mozga krys noradrenalinom.