Activity of pure streptovaricins and fractionated streptovaricin complex against Friend virus.
Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individual intact streptovaricins (A through G and J) show at least a 30-fold reduction in antiviral activity. These results further support the conclusion that the diversified biological properties of streptovaricin complex probably reside in different molecular structures.
D000818:Animals; D005260:Female; D005622:Friend murine leukemia virus / Q000187:drug effects*; D051379:Mice; D008811:Mice, Inbred DBA; D013310:Streptovaricin / Q000302:isolation & purification / Q000494:pharmacology*
D013310:Streptovaricin