Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones.
Several laboratories have documented that glucocorticoid hormones markedly stimulate the expression of mouse mammary tumor virus genes in a variety of mouse mammary tumor cells and in infected heterologous cells. The effect of the hormone appears to be a rapid and specific augmentation of the synthesis of viral RNA, mediated by interaction with glucocorticoid receptor proteins. The availability of virus-specific reagents and recent developments in the molecular biology of RNA tumor viruses now permit a highly refined analysis of hormonal regulation in this experimental system.
D000818:Animals; D002460:Cell Line; D005260:Female; D005814:Genes, Viral; D005938:Glucocorticoids / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental; D008324:Mammary Tumor Virus, Mouse / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects*; D012367:RNA, Viral / Q000096:biosynthesis; D013698:Templates, Genetic; D014158:Transcription, Genetic / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D005938:Glucocorticoids; D012367:RNA, Viral