Inhibitory effect of anti-obesity drugs on NADH dehydrogenase of mouse heart homogenates.
Propylhexedrine and chlorphentermine inhibit the activity of NADH cytochrome c reductase but to a lesser extent than fenfluramine. Diethylpropion and phendimetrazine have little effect.
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D002745:Chlorphentermine / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D009206:Myocardium / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D009251:NADPH-Ferrihemoprotein Reductase / Q000037:antagonists & inhibitors; D011437:Propylamines / Q000494:pharmacology
D001067:Appetite Depressants; D011437:Propylamines; D005277:Fenfluramine; D009247:NADH, NADPH Oxidoreductases; D009251:NADPH-Ferrihemoprotein Reductase; D002745:Chlorphentermine