Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Administration of a diet containing 0.2% N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks induced hepatocellular carcinoma in 3 and renal tubular cell tumors in 7 of 9 Wistar rats. Diet containing 0.1% EHEN induced renal tubular cell tumors in 6 of 10 rats, but no hepatocellular carcinomas. Both diets induced atypical cell population of tubules in the kidney, but no nephroblastoma.
D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology; D004052:Diethylnitrosamine / Q000031:analogs & derivatives; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D009602:Nitrosamines / Q000031:analogs & derivatives; D051381:Rats
D002273:Carcinogens; D009602:Nitrosamines; C023845:N-ethyl-N-hydroxyethylnitrosamine; D004052:Diethylnitrosamine