Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization.
Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a so-called "bystander effect" of a cell-mediated immune response (bystander demyelination).
D000818:Animals; D000956:Antigens, Viral; D003711:Demyelinating Diseases / Q000276:immunology; D007111:Immunity, Cellular; D007114:Immunization; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology*; D014790:Visna-maedi virus / Q000276:immunology*
D000956:Antigens, Viral