[Comparative study of the hemolytic action of group D vitamins].
Hemolytic effects of the vitamins of the D group (ergocalciferol - D2, cholecalciferol - D3, and 1 alpha-hydroxycholecalciferol - 1 alpha-OH-D3) were compared using rat erythrocytes. The latent period of hemolysis, caused by 1 alpha-OH-D3 was approximately 3-fold shorter as compared with the hemolysis caused by D2 or D3. Apparent values for energy of activation of hemolysis, estimated at 30-45 degrees, constituted for D2 - 23.2 kcal/mol, D3 - 25.3 kcal/mol, 1 alpha-OH-D3 - 13.1 kcal/mol. Despite the higher hemolytic activity, the rate of 1 alpha-ON-D3 autooxidation was distinctly lower than that of D3.
D000818:Animals; D002762:Cholecalciferol / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004872:Ergocalciferols / Q000633:toxicity; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D007700:Kinetics; D051381:Rats; D013329:Structure-Activity Relationship; D013696:Temperature; D013997:Time Factors; D014807:Vitamin D / Q000633:toxicity*
D004872:Ergocalciferols; D014807:Vitamin D; D002762:Cholecalciferol
Sravnitel'noe izuchenie gemoliticheskogo dĭstviia vitaminov gruppy D.