Diazepam potentiation of purinergic depression of central neurons.
Intravenously or iontophoretically applied diazepam potentiated the depressant action of iontophoretically applied 5'-AMP on the spontaneous firing of rat cerebral cortical neurons. This potentiation of purinergic depression may be a result of the previously reported inhibition by diazepam of uptake of adenosine into brain tissues.
D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011684:Purine Nucleosides / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D011684:Purine Nucleosides; D011687:Purines; D000242:Cyclic AMP; D000241:Adenosine; D003975:Diazepam