title: [Modern concepts of the metabolism and genetic polymorphism of collagen (a review)].
abstract: The data on structure, biosynthesis, post-synthetic modifications, extracellular development and degradation of collagen are briefly reviewed. Role of main enzymes, participating in collagen turnover, is discussed. Isoforms of the protein are considered in details. The importance of studies on collagen proteins is noted in connection with investigations on morphogenesis, cell differentiation, regeneration.
mesh_terms: D000818:Animals; D001831:Body Temperature; D003094:Collagen / Q000096:biosynthesis / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007536:Isomerism; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008968:Molecular Conformation; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism; D011110:Polymorphism, Genetic; D011485:Protein Binding; D014176:Protein Biosynthesis; D011489:Protein Denaturation; D013329:Structure-Activity Relationship
chemical_list: D010455:Peptides; D003094:Collagen; D003012:Microbial Collagenase
vernacular_title: Sovremennye predstavleniia ob obmene i geneticheskom polimorfizme kollagena (obzor).