title: Subacute combined degeneration of the spinal cord and the vitamin B12 metabolism, a clinical study.
abstract: In 28 patients suffering from subacute combined degeneration of the spinal cord, vitamin B12 metabolism was investigated. Two postulates, proving vitamin B12 deficiency and excluding another cause for the clinical symptoms, have to be fulfilled. Two patients had no disturbance in their vitamin B12 metabolism. Seven patients had a distinct vitamin B12 deficiency. In the remaining 19 patients we found a mild vitamin B12 deficiency. Of these patients, 5 had had a subtotal gastrectomy, one had had a low absorption of vitamin B12, and 13 patients we could not find a distinct cause for the vitamin B12 deficiency. It is not impossible that nutritional habits can be hold responsible for this deficiency. The question whether these 13 patients should be treated with vitamin B12 for the rest of their lives is difficult to answer. It is a conditio sine qua non that in the patients with S.C.D. the vitamin B12 metabolism is examined circumstantially. By so doing, it may be possible to detect, in cases with minor clinical signs and symptoms of S.C.D., the cause of their illness.
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005492:Folic Acid / Q000378:metabolism / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D012008:Recurrence; D013116:Spinal Cord / Q000378:metabolism; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D014805:Vitamin B 12 / Q000378:metabolism* / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D005492:Folic Acid; D014805:Vitamin B 12; D006879:Hydroxocobalamin