Two mechanisms of interferon production by leukocytes from immunized animals.
Leukocytes from animals immunized against measles were treated with different doses of interferon and 5-fluorouracil. Under the influence of virus-inducer, two mechanisms of interferon production were realized in the leukocytes: early after immunization (1 day), pre-existing interferon was released; subsequently (4 days) de novo interferon production was started. Interferons induced in cultures of leukocytes from animals at 1 and 4 days after immunization were shown to differ in some physico-chemical properties.
D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D002478:Cells, Cultured; D005472:Fluorouracil / Q000494:pharmacology; D007114:Immunization; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis / Q000097:blood; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008457:Measles / Q000276:immunology; D008459:Measles virus / Q000276:immunology; D011817:Rabbits; D014762:Viral Interference / Q000187:drug effects
D000914:Antibodies, Viral; D007369:Interferon Inducers; D007372:Interferons; D005472:Fluorouracil