L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.
A number of putative neurotransmitter substances and their antagonists were applied to the carp retina while intracellular recordings from L-type cone horizontal cells were made. Of all the substances tested, L-aspartate was found to be the most potent agent in depolarizing these horizontal cells in dark-adapted, partially light-adapted, and Co2+-treated retinas. Furthermore, DL-alpha-aminoadipate, an L-aspartate antagonist, blocked the effects of both the endogenous photoreceptor transmitter and exogenously applied L-aspartate on the horizontal cells. The results suggest that L-aspartate and the natural transmitter interact with the same population of postsynaptic receptors in the horizontal cell membrane.
D015074:2-Aminoadipic Acid / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000502:physiology*; D002347:Carps / Q000502:physiology*; D003530:Cyprinidae / Q000502:physiology*; D066298:In Vitro Techniques; D010786:Photoreceptor Cells / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D009435:Synaptic Transmission
D015074:2-Aminoadipic Acid; D001224:Aspartic Acid