Intra- and extraneuronal formation of the two major noradrenaline metabolites in the cns of rats.
The two major noradrenaline metabolites in the rat brain, total 3-methoxy-4-hydroxyphenylglycol (MOPEG) and total 3,4-dihydroxyphenylglycol (DOPEG), were measured by a new analytical procedure after intraventricular (i.v.t.) injection of (3-H) noradrenaline or (3-H) dopamine. I.v.t. injection of (3-H) noradrenaline to rats with a 6-hydroxydopamine-induced destruction of nerve terminals in the central nervous system, resulted in an increased accumulation of 3-H-MOPEG compared to 3-H-DOPEG. On the contrary, reserpine induced a greater increase in 3-H-DOPEG than in 3-H-MOPEG accumulation when these two metabolites were formed from (3-H) noradrenaline synthesized in vivo by i.v.t. injection of (3-H) dopamine. These results indicate that the formation of DOPEG and MOPEG occur with some preference intra- and extraneuronally, respectively. The results, however, also show that these two formations sites should not be considered as specific.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006018:Glycols / Q000032:analysis*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D010293:Pargyline / Q000008:administration & dosage; D051381:Rats; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014316:Tritium
D006018:Glycols; D006892:Hydroxydopamines; D014316:Tritium; D008734:Methoxyhydroxyphenylglycol; D012110:Reserpine; D010293:Pargyline; D004298:Dopamine; D009638:Norepinephrine