Pulmonary edema related to changes in colloid osmotic and pulmonary artery wedge pressure in patients after acute myocardial infarction.
Pulmonary artery wedge and plasma colloid osmotic pressures and their relationship to pulmonary edema were investigated in 26 patients with acute myocardial infarction of whom 14 developed pulmonary edema. In the absence of pulmonary edema, both the pulmonary artery wedge pressure and plasma colloid osmotic pressure were in normal range; after onset pulmonary edema, a moderate increase in pulmonary wedge pressure and reduction in plasma colloid osmotic pressure were observed. When the gradient between the plasma colloid osmotic pressure and the pulmonary artery wedge pressure was calculated, highly significant differences were demonstrated (P less than 0.002). In the absence of pulmonary edema, this gradient averaged 9.7 (plus or minus 1.7 SEM) torr; following appearance of pulmonary edema, it was reduced to 1.2 (plus or minus 1.3) torr. During therapy with digoxin and furosemide, reversal of pulmonary edema was closely related to a concomitant change in the colloid osmotic-hydrostatic pressure gradient. These observations indicate that both increases in pulmonary capillary pressure and decreases in colloid osmotic pressure may follow the onset of pulmonary edema. Such decline in colloid osmotic pressure and especially the reduction in colloid osmotic-hydrostatic capillary pressure gradient may favor transudation of fluid into the lungs.
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002302:Cardiac Output; D004077:Digoxin / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006339:Heart Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D009997:Osmotic Pressure; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000209:etiology* / Q000503:physiopathology; D012119:Respiration; D012770:Shock, Cardiogenic / Q000188:drug therapy / Q000503:physiopathology; D014882:Water-Electrolyte Balance
D004077:Digoxin; D005665:Furosemide; D010100:Oxygen