Immunopathogenicity and oncogenicity of murine leukaemia virus. IV. Antinuclear antibody response and tumour induction in B10.A recombinant mice.
The levels of murine leukaemia virus (MuLV) proteins p30 and gp70, antinuclear antibody (ANA), anti-soluble nuclear protein, anti-single-stranded DNA, anti-double-stranded DNA and anti-histone antibodies were measured in B10.A and B10.A recombinant mice neonatally infected with MuLV-Scripps (Lerner et al., 1972). The incidence and latency of lymphoma and the incidence of glomerulonephritis were also determined. The mice studied could be divided into high-responder and low-responder groups. Most of the high ANA antibody could be attributed to anti-histone antibody. High response was associated with the H-2b haplotype and recombinant strains on the B10 background which were identical at the I-A subregion derived from the H-2b parental stock. In contrast, low ANA response was associated with the I-A subregion derived from the H-2k haplotype. In all groups of virus-inoculated animals, most animals developed serum elevations of p30 and gp70 and at least 72% of the inoculated animals developed lymphomas. High serum p30 levels correlated inversely with latency and directly with gp70 values. From 4 to 28% of the animals in each virus-inoculated group had histological evidence of glomerulonephritis, although no clear genetic basis could be ascribed to the incidence of glomerulonephritis, serum p30 or gp70 levels, or latency of lymphoma development.
D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; D000917:Antibody Formation; D002273:Carcinogens; D005921:Glomerulonephritis / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D011995:Recombination, Genetic
D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; D002273:Carcinogens