title: [Headache following intrathecal therapy in acute leukemia: trial of tiapride as a symptomatic treatment (author's transl)].
abstract: 11 patients experienced 40 intrathecal injections of cytotoxic drugs during the treatment of acute leukemia. Tiapride was used as a preventive or curative therapy for headache. Results were found excellent or good in 70% of cases. Frequency and intensity of headache were reduced by half. Tiapride seems more effective in early headache than in cephalalgia occuring later.
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001549:Benzamides / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006261:Headache / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007278:Injections, Spinal; D007938:Leukemia / Q000188:drug therapy*; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D013976:Tiapamil Hydrochloride / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D001549:Benzamides; D003561:Cytarabine; D013976:Tiapamil Hydrochloride; D008727:Methotrexate
vernacular_title: Traitement des céphalées secondaires à l'injection intra-rachidienne d'antimitotiques.