Functional consequences of treating turkey liver fructose-1,6-bisphosphatase with penicillin G.
Treatment of turkey liver fructose-1,6--bisphosphatase with penicillin G progressively inactivated the enzyme and desensitized the enzyme toward high substrate inhibition. The treatment also led to reduced sensitivity to AMP inhibition and the loss of cooperative interaction among AMP-binding sites. These altered properties were not reversed by dialysis, but were prevented when treatment with penicillin G was perfomed in the presence of substrate.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D006597:Fructose-Bisphosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D010400:Penicillin G / Q000494:pharmacology*; D014422:Turkeys
D000249:Adenosine Monophosphate; D006597:Fructose-Bisphosphatase; D010400:Penicillin G