title: Aminoglycosides from the clinical microbiologist's viewpoint.
abstract: The author is discussing the aminoglycosides from the clinical microbiologists viewpoint. It is both an review of the literature and a personal attempt to put into perspective some of his own experience with these agents and reports in the literature. He is discussing the influence of the culture media composition of the outcome of susceptibility tests with these agents as well as the problems of bacterial resistance. Furthermore the topic of rapid and reasonably accurate serum drug level determination. Finally he gives some brief comments to the question of synergism or antagonism with other mainly penicillin type antibiotics.
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium; D002228:Carbenicillin / Q000494:pharmacology; D003470:Culture Media; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007612:Kanamycin / Q000494:pharmacology; D007709:Klebsiella / Q000187:drug effects; D008274:Magnesium; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D005839:Gentamicins; D007612:Kanamycin; D002228:Carbenicillin; D008274:Magnesium; D002118:Calcium