[Myocardial metabolism under intravenous infusion of glucagon (author's transl)].
In 7 healthy-hearted probands the arterial-coronary-venous oxygen difference for glucose, K+, lactate, pO2, pCO2 and pH during a glucagon infusion was determined and compared with the values before and 10 minutes after infusion. Contradictory to the unchanged myocardial lactate extraction and the positively or negatively influenced K+-uptake recorded in the literature, in this contingent there was a statistically significant myocardial lactate production and an unchanged potassium uptake. The respiratory quotient of the heart increased. These changes are regarded as the result of a direct hormonal influence on the myocardial metabolism and have nothing to do with the change of an aerobic into an anaerobic metabolic state.
D001158:Arteries; D001786:Blood Glucose / Q000032:analysis; D006328:Cardiac Catheterization; D003331:Coronary Vessels; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007773:Lactates / Q000096:biosynthesis / Q000097:blood; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D011188:Potassium / Q000097:blood / Q000378:metabolism; D014680:Veins
D001786:Blood Glucose; D007773:Lactates; D005934:Glucagon; D011188:Potassium; D010100:Oxygen
Verhalten des Myokardmetabolismus unter intravenöser Glukagoninfusion