Pathways of arachidonic acid metabolism and modulation by drugs.
The AA cascade in addition to producing various oxygenation products concomitantly yields an oxygen radical. This oxidant selectively deactivates the cyclooxygenase, peroxidase and PGI2 synthetase components whereas TXA2 synthetase is resistant to this oxidant. On the basis of available data it is not possible to assign an inflammatory inducing role to this oxidant on the basis of these actions. Other loci of action must be involved. Among the possibilities are the elements involved in the release of arachidonic acid. Studies relating to this possibility are examined in this report.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007454:Iodides / Q000494:pharmacology; D008084:Lipoxygenase / Q000378:metabolism; D011398:Promethazine / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D013481:Superoxides
D001095:Arachidonic Acids; D007454:Iodides; D011453:Prostaglandins; D011458:Prostaglandins E; D013481:Superoxides; D003907:Dexamethasone; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D011398:Promethazine; D007213:Indomethacin