title: Stimulation of adrenergic nerve fibres to the urinary bladder of the rat.
abstract: The contraction of the rat detrusor muscle caused by electrical stimulation of the hypogastric or pelvic nerves was followed by relaxation when the nerves were stimulated for a short period. The relaxation was more pronounced when the initial contraction was reduced by atropine. It was found to be mediated by adrenergic fibres acting on inhibitory beta2-receptors. Stimulation of the hypogastric or pelvic nerves at high frequencies increased the contractile response probably via adrenergic fibres activating excitatory alpha-receptors.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004087:Dihydroergotamine / Q000494:pharmacology; D004558:Electric Stimulation; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011312:Pressure; D051381:Rats; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation* / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists; D004087:Dihydroergotamine; D001285:Atropine