title: A live vaccine against tick-borne encephalitis; integrated studies, H. Histopathology of mice peripherally immunized with E5 "14" virus and challenged with virulent virus.
abstract: Histopathological changes in the central nervous and lymphoid systems were semiquantitatively analyzed in subadult mice (M) peripherally immunized with the live, highly attenuated E5 "14" virus from the tick-born encephalitis (TE) complex and in immunized M subjected to virulent challenge. The E5 "14" clone possesses an exceedingly restricted neuroinvasivity. A study of the sc marker, refined and extended by microscopic examinations seems to present a more relevant approach for comparative investigations on TE virus virulence. Morphological findings in immunized M given immunosuppressive doses of cyclophosphamide (CPA) suggest that the high efficiency of live vaccines may be related to the prolonged antigenic stimulation.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D001103:Arboviruses; D001921:Brain / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology / Q000472:pathogenicity; D004675:Encephalitis, Tick-Borne / Q000473:pathology / Q000517:prevention & control*; D000882:Haplorhini; D007165:Immunosuppression Therapy; D051379:Mice; D013154:Spleen / Q000473:pathology; D014611:Vaccination; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D003520:Cyclophosphamide