Changes of the oxidative phosphorylation in mitchondria of rat skeletal muscle following strenous exercise.
The rate of oxygen consumption of mitochondria from rat muscles at pH 7.4 is elevated by 1-lactate. The respiratory control ratio and the ADP/O-ratio are decreased under these conditions. Acidification to pH 6.5 in the absence of 1-lactate does not change the interpreted mitochondrial functions. The experimental data are discussed as a partial uncoupling effect of 1-lactate on the oxidative phosphorylation. Similar changes in those mitochondrial functions are found after short-time intensive swimming exercise of rats. These variations might be a reason for the sometimes described reduced aerobic performance after intensive work.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003470:Culture Media; D005971:Glutamates / Q000378:metabolism; D006614:Hindlimb; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008297:Male; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009132:Muscles / Q000648:ultrastructure; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D005082:Physical Exertion; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D014475:Uncoupling Agents
D003470:Culture Media; D005971:Glutamates; D007773:Lactates; D008293:Malates; D011773:Pyruvates; D014475:Uncoupling Agents; D000244:Adenosine Diphosphate