Factors effecting drug release from inert matrices. Part 1: effects of surfactants on the release of quinine sulfate.
Dissolution rate studies of quinine sulfate from polyamide matrices, in simulated gastric and intestinal fluids, are carried out in the presence of hexadecyltrimethylammonium bromide, sodium lauryl sulfate and polyoxyethylene (50) stearate surfactants. The results obtained show that dissolution rate is dependent upon the pH of the disolution media and the type and concentration of surfactant. The solubilization effect of surfactants is also examined and the findings are discussed.
D002626:Chemistry, Pharmaceutical; D005750:Gastric Juice / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011803:Quinine / Q000378:metabolism; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D013431:Sulfates / Q000378:metabolism; D013501:Surface-Active Agents / Q000494:pharmacology; D013607:Tablets
D013431:Sulfates; D013501:Surface-Active Agents; D013607:Tablets; D012967:Sodium Dodecyl Sulfate; D011803:Quinine