Processes of transport and absorption in the developing infant intestine.
An understanding of changes in the processes of absorption, detoxification, and intoxication in the intestine of infants, especially during the perinatal period, may aid in reaching an understanding of why the syndrome of infant botulism is restricted to the first six months of life. Some of the important metabolic changes associated with both the perinatal and the postnatal period of development are emphasized in these studies. A more complete understanding of the processes by which substances are absorbed into the intestine and then reexposed via the enterohepatic circulation may provide clues about why infant botulism occurs.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D004734:Energy Metabolism; D004764:Enterohepatic Circulation; D004790:Enzyme Induction / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D007223:Infant; D007231:Infant, Newborn; D007408:Intestinal Absorption; D007422:Intestines / Q000201:enzymology / Q000254:growth & development*; D008928:Mitochondria / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism
D000072317:Polychlorinated Dibenzodioxins; D011768:Pyruvate Dehydrogenase Complex; D009243:NAD; D000255:Adenosine Triphosphate; D014453:Glucuronosyltransferase