Uptake of 131I-19-cholesterol by normal and spontaneously hyperfunctioning canine adrenals.
In six normal dogs the adrenals could be visualized as separate areas of radioactivity at 7--10 days after injection of 20--40 muCi 131I-iodocholesterol per kg of body weight. Image analysis revealed uptake values of 0.15--0.3% of the injected dose. In five dogs with pituitary-dependent hyperadrenocorticism the adrenals became visible at 3--5 days after injection of the radiopharmaceutical, with uptake values of 0.38--2.2%. In six dogs with hyperadrenocorticism due to adrenocortical tumor the scintigraphy contributed to the diagnosis and the presurgical localization. The uptake values were within the normal range; the tumor could be observed at 3--10 days after injection. Additional findings on adrenal asymmetry and a case of fluctuating pituitary-dependent hyperadrenocorticism are discussed.
D015071:19-Iodocholesterol / Q000378:metabolism; D000303:Adrenal Cortex Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D000311:Adrenal Glands / Q000000981:diagnostic imaging* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives*; D004285:Dogs; D007457:Iodine Radioisotopes / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011877:Radionuclide Imaging; D013268:Stimulation, Chemical
D007457:Iodine Radioisotopes; D015071:19-Iodocholesterol; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol