Perinatal induction of medulloblastomas in Syrian golden hamsters by a human polyoma virus (JC).
Medulloblastomas, originating from cells of the internal granular layer of the cerebellum, developed in Syrian golden hamsters 3--6 months after inoculation at birth intracerebrally and sc with JC virus, a papovavirus isolated originally from a human case of the demyelinating disease progressive multifocal leukoencephalopathy. The lesion is compared with the human medulloblastoma of childhood. JC virus is the first infectious agent to produce such a neoplasm in any species.
D000818:Animals; D000831:Animals, Newborn; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D006224:Cricetinae; D008527:Medulloblastoma / Q000209:etiology* / Q000473:pathology; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology; D011120:Polyomavirus; D014412:Tumor Virus Infections / Q000209:etiology*