title: Modification by SQ 14225 of blood pressure and adrenal catecholamine response to hemorrhage.
abstract: SQ 14225 infusion to cats exposed to hemorrhage suppressed adrenomedullary catecholamine release. The immediate compensatory blood pressure response was unaffected, while the later compensatory response was of a higher magnitude in intact cats that in SQ 14225-treated animals. Adrenal gland blood flow was better preserved in SQ 14225-treated hemorrhaged cats than in cats exposed to hemorrhage only. These  data emphasize the role of angiotensin II in adrenal catecholamine and blood pressure responses to hemorrhage.
mesh_terms: D000311:Adrenal Glands / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D002415:Cats; D005260:Female; D006470:Hemorrhage / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002395:Catecholamines; D011392:Proline