Effect of vitamin A on plasminogen activator synthesis by chick embryo fibroblasts.
Low concentrations of Vitamin A stimulated plasminogen activator synthesis (PA) in chick embryo fibroblasts (CEF). It caused a dose dependent and reversible increase in PA synthesis in both normal CEF and CEF infected with a temperature sensitive mutant of Rous Sarcoma virus (RSV-Ts68). Both induction and deinduction of PA could be inhibited by Actinomycin D. Vitamin A also accentuated the morphological changes associated with transformation in the Rous Sarcoma virus infected cells. The effects of Vitamin A on PA synthesis were essentially similar to those of the known tumour promoter, phorbol myristate acetate (PMA). Both Vitamin A and PMA were found to act synergistically with sarcoma gene expression as far as PA synthesis was concerned.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D002645:Chickens; D002772:Cholera Toxin / Q000494:pharmacology; D009712:Nucleotides, Cyclic / Q000494:pharmacology; D010960:Plasminogen Activators / Q000096:biosynthesis*; D013696:Temperature; D014212:Tretinoin / Q000494:pharmacology; D014801:Vitamin A / Q000494:pharmacology*
D009712:Nucleotides, Cyclic; D014801:Vitamin A; D014212:Tretinoin; D002772:Cholera Toxin; D010960:Plasminogen Activators