Effect of various solubilizers on angiotensinII receptors in bovine adrenocortical plasma membranes.
3 nonionic detergents, Triton X-100, Lubrol WX and NP-40, inhibited binding of [3H]-ATII to bovine adrenocortical plasma membranes. This effect appeared to be direct and not due to solubilization of the ATII receptor by these agents. Sodium deoxycholate and the chaotropic ions, ClO4- and Br-, produced effects similar to the nonionic detergents.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects; D003902:Detergents; D008563:Membrane Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000302:isolation & purification; D011945:Receptors, Angiotensin / Q000187:drug effects* / Q000302:isolation & purification; D011956:Receptors, Cell Surface / Q000187:drug effects*; D012995:Solubility
D003902:Detergents; D008563:Membrane Lipids; D008565:Membrane Proteins; D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface