title: Interaction of hemoglobin with three ligans: organic phosphates and the Bohr effect.
abstract: The assumption that the Bohy coefficient (less than log p 50)/(less than pH) is equal to the haldane coefficient (less than h minus plus) of hemoglobin is shown to be incorrect in the presence of allosteric effectors such as 2,3-diphosphoglycerate. The theoretical relation between the two coefficients in the presence of 2.3-diphosphoglycerate as derived. Experimental data on the variation of both coefficients with diphosphoglycerate concentration are presented and shown to be in agreement with prediction.
mesh_terms: D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008433:Mathematics; D010100:Oxygen / Q000097:blood*; D011485:Protein Binding
chemical_list: D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D008024:Ligands; D010100:Oxygen