Simultaneous binding of three Na+ and two K+ ions to Na+,K+-dependent ATPase and changes in its affinities for the ions induced by the formation of a phosphorylated intermediate.
D000818:Animals; D001665:Binding Sites; D002414:Cations, Monovalent; D007679:Kidney Medulla / Q000201:enzymology; D007700:Kinetics; D010766:Phosphorylation; D011188:Potassium; D011485:Protein Binding; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase / Q000302:isolation & purification / Q000378:metabolism; D013552:Swine
D002414:Cations, Monovalent; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium