Hindlimb extensor reflex of spinal rats given tranylcypromine stereoisomers.
The hindlimb extensor reflex of reserpinized, spinal rats was used to determine whether tranylcypromine (dl-TCP) and its stereoisomers (d-TCP and l-TCP) after tryptaminergic neurotransmission. dl-TCP and d-TCP caused an extensor reflex while l-TCP failed to cause a reliable extensor reflex. Neither H 22/54 nor nialamide affected the extensor reflex in rats given dl-TCP, while H 22/54 reduced the reflex in rats given d-TCP. The results suggest that dl-TCP and d-TCP have direct as well as indirect actions on tryptaminergic neurotransmission.
D000818:Animals; D006614:Hindlimb; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D013237:Stereoisomerism; D009435:Synaptic Transmission / Q000187:drug effects*; D014191:Tranylcypromine / Q000494:pharmacology*; D014363:Tryptamines / Q000378:metabolism*
D014363:Tryptamines; D014191:Tranylcypromine