title: The syndrome of diabetic amyotrophy.
abstract: Changes in the electromyograms and motor nerve conduction velocities in 12 patients with diabetic amyotrophy suggested mild distal and moderate proximal neuropathy in the lower limbs. Histological and histochemical findings in the vastus medialis muscles were consistent with denervation. Electron microscopical examination of the vastus medialis muscles in 6 patients revealed myofibrillar degeneration. One patient had abnormal mitochondria and tubular aggregates. The basement membranes of the intramuscular capillaries were thickened in all but 1 patient. Histochemical staining of the myoneural junctions showed changes consistent with degeneration and regeneration. We conclude that diabetic amyotrophy is a distinct clinical entity and is secondary to metabolic derangement rather than  diabetic microangiopathy.
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004576:Electromyography; D006801:Humans; D007866:Leg / Q000294:innervation; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009123:Muscle Hypotonia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D009132:Muscles / Q000378:metabolism / Q000648:ultrastructure; D009133:Muscular Atrophy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D009431:Neural Conduction; D013127:Spinal Nerves / Q000503:physiopathology; D009435:Synaptic Transmission
chemical_list: D001786:Blood Glucose