Effects of Haemophilus influenzae vaccination on the (para-)sympathic-cyclic nucleotide-histamine axis in rats.
To determine whether Haemophilus influenzae could be a factor in human atopy its effects were studied on the (para-)Sympathic Cyclic nucleotide-histamine axis in rats. Haemophilus influenzae vaccination induced changes in the cholinergic system compatible with higher cyclic GMP levels and enhanced histamine release. The authors suggest an involvement of the cholinergic system in Haemophilus influenzae vaccination effects.
D000818:Animals; D001428:Bacterial Vaccines / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism; D002802:Cholinesterases / Q000097:blood; D006152:Cyclic GMP / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D006193:Haemophilus influenzae / Q000276:immunology*; D006632:Histamine / Q000097:blood / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D051381:Rats
D001428:Bacterial Vaccines; D002395:Catecholamines; D009712:Nucleotides, Cyclic; D006632:Histamine; D002802:Cholinesterases; D006152:Cyclic GMP; D009638:Norepinephrine; D004837:Epinephrine