Phagocytosis and intracellular fate of Sporothrix schenckii.
Human polymorphonuclear leukocytes (PMNLs) phagocytized and killed yeast-phase cells of Sporothrix schenckii in vitro in the presence of 10% unheated serum. The combination of H2O2, KI, and human PMNL myeloperoxidase was lethal to yeast-phase S. schenckii. The results of this investigation suggest that PMNLs may play an important role in host resistance to infection with S. schenckii.
D002176:Candida albicans / Q000276:immunology; D002470:Cell Survival; D002712:Chlorides / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D007454:Iodides / Q000494:pharmacology; D009504:Neutrophils / Q000382:microbiology; D009195:Peroxidase / Q000494:pharmacology; D010587:Phagocytosis; D013175:Sporothrix / Q000276:immunology*; D015003:Yeasts
D002712:Chlorides; D007454:Iodides; D009195:Peroxidase