Simultaneous pharmacokinetics of alclofenace in plasma and synovial fluid in patients with rheumatoid arthritis.
The simultaneous pharmacokinetics of alclofenac in the plasma and synovial fluid of 10 patients with rheumatoid arthritis were studied after a single 1 g. oral dose. A gas-liquid chromatographic method was used for assaying alclofenac in both plasma and synovial fluid. Alclofenac readily appears in the plasma and synovial fluid.
D000284:Administration, Oral; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D006801:Humans; D010648:Phenylacetates / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism*
D010648:Phenylacetates