Plasma levels of complement components and complement haemolytic activity in protein-energy malnutrition.
The plasma levels of complement haemolytic activity (CH50) of some complement components and of C3d, a C3 breakdown product, were measured in fifty-nine African children with various types of protein-energy malnutrition (PEM) including kwashiorkor, before and during recovery. A significant decrease of CH50, C3, C9 and factor B was observed in PEM without a concomitant decrease of C4 and C5. Increased plasma levels of C3d were also found in PEM patients. Two mechanisms seem to be involved in the impairment of the complement system in PEM: (1) a decreased synthesis of at least C3 and C9 as suggested by a significant correlation between C3 or C9, levels and those of albumin and cholinesterase; (2) an increased catabolism of C3 possibly due to an activation of the alternative complement pathway, as suggested by the increased level of C3d and the decreased level of factor B which are significantly correlated with C3 levels but not with albumin levels. These data support the possible role of a relative complement deficiency upon the decreased resistance to infections observed in malnourished children.
D002675:Child, Preschool; D002802:Cholinesterases / Q000378:metabolism; D003176:Complement C3 / Q000032:analysis; D003186:Complement C9 / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D011416:Complement Factor D / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis* / Q000276:immunology; D007560:Cote d'Ivoire; D006461:Hemolysis; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000276:immunology; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000201:enzymology / Q000276:immunology*; D012709:Serum Albumin
D003176:Complement C3; D003186:Complement C9; D012709:Serum Albumin; D003165:Complement System Proteins; D002802:Cholinesterases; C493488:CFD protein, human; D011416:Complement Factor D; D011415:Complement Factor B