title: Chromatographic separation of conformers of substituted asymmetric nitrosamines.
abstract: The syn and anti conformers of N-nitrosoproline, N-nitrososarcosine and N-nitroso-2-(ethylamino)-ethanol, have been separated by liquid chromatography. These conformers result from hindered rotation about the N-N bond. Separation was achieved using adsorption, reversed-phase, and ion-exchange modes. For the nitroso-amino acids, a shift in the equilibrium conformer concentration was observed with changes in pH.
mesh_terms: D002845:Chromatography; D004983:Ethanolamines / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins; D008722:Methods; D008968:Molecular Conformation; D009602:Nitrosamines / Q000032:analysis*; D009904:Optical Rotation; D011312:Pressure; D011392:Proline / Q000031:analogs & derivatives / Q000032:analysis; D012521:Sarcosine / Q000031:analogs & derivatives / Q000032:analysis; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D004983:Ethanolamines; D007475:Ion Exchange Resins; D009602:Nitrosamines; D012997:Solvents; D011392:Proline; D012521:Sarcosine