[Splenic lympho-plasmocytic sarcomas discovered by exploratory laparotomy in 2 cases of cold agglutinin disease].
The 2 patients have cold agglutinin disease with lymphoid nodules in the bone marrow. A splenectomy was done because of the severity of the hemolytic anemia and because of the increasing splenomegaly. Tumoral nodules with the aspect of lymphoplasmocytic sarcoma or immunocytoma were discovered in the spleen. Those tumors can be considered either as a morphologic aspect of the cold agglutinin disease which is yet considered as a kind of chronic lymphoproliferative syndrom or as the proliferation of an other clone. In this hypothesis, the lymphoplasmocytic sarcoma habe the same signification that the Richter's syndrome in chronic lymphoid leukemia and that the sarcoma appearing in Waldenström's macroglobulinemia or in alpha heavy chain disease.
D000005:Abdomen; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006362:Heavy Chain Disease / Q000150:complications; D006801:Humans; D007137:Immunoglobulin alpha-Chains; D007945:Leukemia, Lymphoid / Q000150:complications; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000209:etiology*; D008232:Lymphoproliferative Disorders / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*; D013154:Spleen / Q000473:pathology; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000209:etiology*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications
D007137:Immunoglobulin alpha-Chains
Sarcomes lympho-plasmocytaires spléniques découverts par laparotomie exploratrice au cours de deux cas de maladie chronique des agglutinines froides.