Cushing's disease with pituitary apoplexy leading to hypopituitarism, empty sella, and spontaneous fracture of the dorsum sellae. Case report.
A patient with a pituitary adenoma secreting adrenocorticotropin hormone manifested panhypopituitarism after an episode of pituitary apoplexy. The previously elevated urinary levels of 17-ketogenic steroids dropped sharply, and plasma cortisol became undetectable. The apoplexy also resulted in a partially empty sella on which the dorsum sellae collapsed. Recurrent Cushing's disease developed and was cured by transsphenoidal resection of a microadenoma.
D000238:Adenoma, Chromophobe / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D002561:Cerebrovascular Disorders / Q000150:complications*; D003480:Cushing Syndrome / Q000150:complications*; D004652:Empty Sella Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D012008:Recurrence; D012658:Sella Turcica / Q000293:injuries*; D014056:Tomography, X-Ray
D000324:Adrenocorticotropic Hormone