title: Regulation of persistent infection with herpes simplex virus in vitro by hydrocortisone.
abstract: About 1% of Raji cells showed sensitivity to herpes simplex virus type 2 (HSV-2) infection when tested by infectious center assays or immunofluorescence tests, and the percentage did not change during cell passage. The addition of hydrocortisone to Raji cells persistently infected with HSV-2 caused a marked increase in virus production and in the number of HSV-producing cells. In the case of HSV-1, it was shown that the addition of hydrocortisone was required to maintain persistent infection. These observations suggest that control of replication of HSV-1 and HSV-2 in these cells is regulated by different mechanisms.
mesh_terms: D002051:Burkitt Lymphoma / Q000382:microbiology; D002460:Cell Line; D005455:Fluorescent Antibody Technique; D006854:Hydrocortisone / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D006854:Hydrocortisone