Effects of cadmium on the immune system of mice.
Chronic oral exposure of mice to Cd++ inhibits cell-mediated immunity of delayed type hypersensitivity induced by sheep red blood cells (SRBC). No effect was detected on humoral immune response to SRBC. Spleen cells derived from mice exposed to Cd++ showed in vitro enhanced response to T and B cell mitogens. These results demonstrate that Cd++ exposure alters the immune system of mice.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D002105:Cadmium Poisoning / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed; D051379:Mice; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology