[Opiate receptor sites in neuronal and glial cell lines in culture].
A stereospecific saturable high affinity binding of 3H-naloxone has been found in 3 glial and 2 neuronal cell lines. Kinetic study of binding seems to indicate only one class of receptor sites in the 5 cell lines. Acute exposure to morphine (1 X 10(-5)M) concurrent with PGE1-induced stimulation of adenylate cyclase did not result in a decrease of the cAMP level in any cell line tested.
D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011957:Receptors, Opioid / Q000032:analysis* / Q000378:metabolism
D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D000242:Cyclic AMP
Sites récepteurs des opiacés dans des lignées neuronales et gliales de cellules en culture.