The effects of Staphylococcus aureus and Klebsiella pneumoniae peritonitis in mice exposed to normal and hypoxic conditions on red cell oxygen transport function.
Normal mice exposed to 10% oxygen concentration developed a slight but statistically significant decrease in blood pH and a slight statistically insignificant decrease in red cell 2,3-DPG. Mice that were infected intraperitoneally with Staphylococcus aureus or Klebsiella pneumoniae and exposed to 20% oxygen developed acidosis, hemoconcentration, and decreased red cell 2,3-DPG levels. When mice with acute bacterial peritonitis were exposed to 10% oxygen concentration they likewise developed significant acidosis and hemoconcentration, but their reduction in red cell 2,3-DPG was not as great as that in the similarly infected mice exposed to 20% oxygen concentration.
D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000503:physiopathology*; D007710:Klebsiella Infections / Q000503:physiopathology*; D007711:Klebsiella pneumoniae; D051379:Mice; D010100:Oxygen / Q000097:blood* / Q000494:pharmacology; D010538:Peritonitis / Q000503:physiopathology*; D013203:Staphylococcal Infections / Q000503:physiopathology*; D013211:Staphylococcus aureus
D004163:Diphosphoglyceric Acids; D010100:Oxygen