Personality dependent effects of the ACTH 4--10 fragment on test performances and on concomitant autonomic reactions.
The effect of the ACTH-fragment 4--10 (30 mg SC) on a mental performance test and on some concomitant cardiovascular changes was investigated in comparison with a placebo in a double blind cross-over study. The subjects were either mainly extraverted or mainly introverted according to Eysenck's 'Maudsley Personality Inventory'. Under the influence of the heptapeptide extraverted subjects achieved a higher total score in the mental task performance with a smaller increase of forearm blood flow and of heart rate than under the influence of the placebo. In contrast, under the influence of the placebo introverted subjects achieved a higher total score in the mental task performance with a smaller increase of forearm blood flow and of heart rate than under the influence of the ACTH-fragment. Personality, therefore, determines to some degree how this centrally acting heptapeptide influences efficiency in the mental task performance and the concomitant cardiovascular changes.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D001341:Autonomic Nervous System / Q000187:drug effects*; D005120:Extraversion, Psychological; D005542:Forearm / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007361:Intelligence Tests; D007439:Introversion, Psychological; D008297:Male; D008606:Mental Processes / Q000187:drug effects*; D010551:Personality; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
D000324:Adrenocorticotropic Hormone