Differential effects of inhibitors of monoamine oxidase Types A and B on the adrenergic system of the rabbit iris.
Topical instillation of inhibitors of monoamine oxidase Types A and B into the rabbit eye, followed by the administration of a releaser of monoamines (Ro 4-1284), induces strong and sustained dilation of the iris. The mydriatic pattern differs markedly with A- and B-inhibitors and with the duration of the inhibitor treatment. The Type B inhibitor, deprenyl, prevents the degradation of exogenous 2-phenylethylamine and possibly of the endogenous amine X capable of releasing monoamines from a compartment less accessible to Ro-1284.
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000480:Alkynes / Q000494:pharmacology; D000818:Animals; D004106:Dilatation; D007498:Iris / Q000187:drug effects*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D013948:Moxisylyte / Q000494:pharmacology; D009184:Mydriatics / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013747:Tetrabenazine / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000480:Alkynes; D008996:Monoamine Oxidase Inhibitors; D009184:Mydriatics; D010627:Phenethylamines; D011437:Propylamines; D008735:5-Methoxytryptamine; D013948:Moxisylyte; D013747:Tetrabenazine