[Pharmacological basis for a fixed association of hydrochlorothiazide, amiloride hydrochloride, and timolol maleate (author's transl)].
The treatment of hypertension requires in many cases a therapeutic combination. This survey, carried out in 96 cases, shows the interest of a fixed combination including a thiazide diuretic (hydrochlorothiazide), a potassium sparing (chlorhydrate of amiloride) and a beta-blocking agent (timolol maleate) as compared to therapy with a beta-blocking agent or diuretic alone. This combination, logical from a pharmacological view point, has proved significantly more effective (81% of patients were normalized) and as well tolerated (none additional side effect) as each of its components. As it simplifies prescription by reducing the number of tablets, it appears a considerable contribution to hypertension therapy.
D000584:Amiloride / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005069:Evaluation Studies as Topic; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy*; D011412:Propanolamines / Q000008:administration & dosage*; D011719:Pyrazines / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage*
D011412:Propanolamines; D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride; D013999:Timolol
Logique pharmacologique d'une association fixe d'hydrochlorothiazide, de chlorhydrate d'amiloride et de maléate de timolol.