Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons.
Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.
D000818:Animals; D002450:Cell Communication; D002478:Cells, Cultured; D004553:Electric Conductivity; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology; D008564:Membrane Potentials; D051379:Mice; D009433:Neural Inhibition; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D013373:Substance P / Q000502:physiology*; D009435:Synaptic Transmission
D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D013373:Substance P