title: A study of the anticholinergic and antispasmodic activity of oxybutynin (Ditropan) on rabbit detrusor.
abstract: Experiments have been conducted which show that while the tertiary amine oxybutynin has only moderate in vitro anticholinergic and antihistaminic activity, it is a potent inhibitor of barium chloride-induced spasms of rabbit detrusor muscle. Oxybutynin exerts 1/13 the anticholinergic activity of propantheline and 1/4 that of atropine, but produces approximately 2x the inhibition of barium chloride-induced spasm than propantheline and 10x the inhibition produced by atropine. In sum, oxybutynin possesses a notable antispasmodic activity distinct from its anticholinergic activity and stronger than that of atropine, propantheline, or methantheline, which may prove useful in the treatment of smooth muscle hypermotility.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001464:Barium / Q000037:antagonists & inhibitors*; D002217:Carbachol / Q000037:antagonists & inhibitors*; D003510:Cyclohexanes / Q000031:analogs & derivatives / Q000494:pharmacology; D004048:Diethylamines / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006634:Histamine H1 Antagonists; D008297:Male; D008333:Mandelic Acids / Q000031:analogs & derivatives* / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011413:Propantheline / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011817:Rabbits; D001743:Urinary Bladder / Q000187:drug effects*
chemical_list: D003510:Cyclohexanes; D004048:Diethylamines; D006634:Histamine H1 Antagonists; D008333:Mandelic Acids; D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; D011413:Propantheline; D001464:Barium; D001285:Atropine; D002217:Carbachol; C005419:oxybutynin