title: Evaluation of indirect hemagglutination and its inhibition in the differentiation between antibodies to herpes simplex virus types 1 and 2 for seroepidemiologic studies: use of a II/I index threshold of 85 and an assay of type-specific antibodies.
abstract: Two parameters, a II/I index threshold value of 85 and an assay of type-specific antibodies to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), were assessed, for seroepidemiologic purposes, for their efficacy in the establishment of past infections with HSV-1 and HSV-2 as indicated by the results of tests for indirect hemagglutination and its inhibition. Neither criterion alone established past infection with either HSV-1 or HSV-2. However, by combination of the two parameters, antibodies to HSV-1 and HSV-2 could be differentiated for seroepidemiologic studies.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000145:classification; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006561:Herpes Simplex / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012703:Serotyping; D018139:Simplexvirus / Q000145:classification / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral