title: Concentration of lidocaine hydrochloride in newborn gastric fluid after elective caesarean section and vaginal delivery with epidural analgesia.
abstract: Lidocaine concentrations were measured after vaginal delivery or Caesarean section with epidural anaesthesia in samples of maternal and umbilical blood and in newborn gastric contents. The pH of the gastric aspirate was also determined in a number of neonates. Gastric lidocaine concentrations were higher and the pH was lower after vaginal delivery in comparison to Caesarean section. A significant inverse correlation exists between gastric pH and gastric lidocaine concentration, Neonate gastric lidocaine concentration  was significantly higher than in maternal or umbilical venous plasma after vaginal delivery, but not after Caesarean section. Due to these differences, gastric lavage for the treatment of neonatal lidocaine intoxication may be more beneficial in reducing foetal systemic local anaesthetic concentration after vaginal than after elective abdominal delivery.
mesh_terms: D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000032:analysis*; D005751:Gastric Lavage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008012:Lidocaine / Q000032:analysis* / Q000097:blood; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D014469:Umbilical Arteries; D014471:Umbilical Veins; D014621:Vagina
chemical_list: D008012:Lidocaine