title: Infectious mononucleosis and related syndromes.
abstract: The "mono syndrome" is an acute febrile disease of older children and young adults which involves the lymphatic system and is characterized hematologically by the presence of 50% or more lymphocytes and monocytes and 10% or more atypical lymphocytes. Epstein-Barr virus (EBV) causes over 90% of the syndrome, cytomegalovirus (CMV) about 5% to 7%, and Toxoplasma gondii less than 1%. Viral hepatitis, adenovirus, rubella, and herpes simplex are rare causes. Only EBV produces classical heterophile-positive infectious mononucleosis. This article reviews the epidemiological and clinical features of this syndrome.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006224:Cricetinae; D003587:Cytomegalovirus / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D007958:Leukocyte Count; D008297:Male; D009000:Monocytes; D011247:Pregnancy; D013577:Syndrome; D014122:Toxoplasma / Q000276:immunology; D065227:Transfusion Reaction
chemical_list: D000906:Antibodies; D000914:Antibodies, Viral