Relief of duodenal ulcer sysmptons by oral metiamide.
Thirty patients with symptoms of duodenal ulceration were treated for five to eight weeks in a double-blind trial with either metiamide 1 g daily by mouth or a placebo. In the 15 patients receiving metiamide there were significant reductions in nocturnal pain and antacid consumption. Daytime pain was diminished. The results suggest that histamine H2-receptor antagonists are likely to be useful in the medical management of the symptoms of duodenal ulceration.
D000284:Administration, Oral; D000863:Antacids / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008785:Metiamide / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy; D010919:Placebos; D013890:Thiourea / Q000031:analogs & derivatives*
D000863:Antacids; D006634:Histamine H1 Antagonists; D010919:Placebos; D008785:Metiamide; D013890:Thiourea