Current concepts of the mechanism of acute inflammation in gouty arthritis.
The acute gouty attack develops after free crystalline monosodium urate crystals appear in the joint cavity (1). Recent developments in the investigation of urate crystal-induced inflammation have led to a better understanding of the pathogenesis of acute gouty arthritis. The purpose of this review is to summarize present concepts concerning the mechanism of the acute gouty attack.
D000208:Acute Disease; D000818:Animals; D001168:Arthritis / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D002633:Chemotaxis; D003165:Complement System Proteins; D003460:Crystallization; D005174:Factor XII / Q000378:metabolism; D006073:Gout / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D007962:Leukocytes / Q000276:immunology / Q000502:physiology; D010587:Phagocytosis; D013582:Synovial Fluid / Q000032:analysis; D014527:Uric Acid / Q000032:analysis / Q000378:metabolism
D007705:Kinins; D014527:Uric Acid; D005174:Factor XII; D003165:Complement System Proteins; D007610:Kallikreins