title: Effects of dosage and cadmium pretreatment on the binding of cadmium in rat bile.
abstract: The effects of dosage and of cadmium pretreatment on the binding of cadmium in rat bile were studied. With increasing dose a higher cumulative biliary excretion of Cd was observed and a higher percentage of the Cd was excreted in a low-molecular-weight form. On the other hand, after cadmium pretreatment, a decrease in the cumulative biliary excretion of cadmium was observed but a greater percentage of that excreted into the bile was bound to high molecular weight compounds.
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D002104:Cadmium / Q000378:metabolism* / Q000494:pharmacology; D002105:Cadmium Poisoning / Q000378:metabolism*; D005260:Female; D008668:Metallothionein / Q000378:metabolism; D008970:Molecular Weight; D051381:Rats; D013997:Time Factors
chemical_list: D002104:Cadmium; D008668:Metallothionein