[Role of lipids in regulation of microsomal glucose-6-phosphatase activity after modification of mcirosomes in vivo and in vitro. Effect of phospholipid effectors on the activity of glucose-6-phosphatase].
Modification of microsomal membranes in vivo and in vitro results in changes of the glucose-6-phosphate and inorganic pyrophosphate phosphohydrolase activities of liver microsomal glucose-6-phosphate phosphohydrolase (EC 3.1.3.9). It was demonstrated that the glucose-6-phosphate phosphohydrolase activity of glucose-6-phosphatase depends on the content of phosphatidylethanolamine in the microsomal membranes, whereas the inorganic pyrophosphate phosphohydrolase activity seems to be dependent on the phosphatidylserine content. It is assumed that the regulation of the corresponding enzyme activities by these phospholipids is performed by the same allosteric mechanism in vitro and in vivo.
D000818:Animals; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D007425:Intracellular Membranes / Q000502:physiology; D007700:Kinetics; D008563:Membrane Lipids / Q000502:physiology*; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010743:Phospholipids / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D008563:Membrane Lipids; D010743:Phospholipids; D005952:Glucose-6-Phosphatase
Issledovanie roli lipidov v reguliatsii aktivnosti mikrosomal'noĭ gliukozo-6-fosfatazy pri modifikatsii mikrosom in vivo i in vitro. Vliianie fosfolipidov-effectorov na aktivnost' gliukozo-6-fosfatazy.