The effect of increased maternal PaO2 upon the fetus during labor.
The effect of increased maternal PaO2 upon the fetus during labor was studied in 36 subhuman primates. The animals were divided into two groups, one in which the fetus was not asphyxiated and showed no evidence of fetal distress (Group I) and another in which the fetus was acidotic, hypoxic, and exhibited the pattern of late deceleration of the heart rate (Group II). One hundred per cent oxygen was administered to the mothers for a period of 30 minutes. Elevation of maternal PaO2 to 430 mm. Hg increased fetal oxygen levels in Group I. and in most instances in Group II, without significant changes in the acid-base state. In Group II, maternal hyperoxemia also abolished or reduced the frequency of late deceleration of the fetal heart in most animals but had little or no effect on fetal blood pressure. Termination of high-concentration oxygen to the mother resulted in a fall in maternal and fetal oxygen levels to their original values and the reappearance of late fetal heart decelerations. Thus, administration of high-concentration oxygen to the mother for the treatment of fetal distress may be of some benefit. The problems of fetal acidosis and hypotension are not cured, however, and may still progress if there is placental insufficiency or cord compression. Therefore, this treatment should be regarded as a temporary supportive measure only.
D000136:Acid-Base Equilibrium; D000818:Animals; D001238:Asphyxia Neonatorum / Q000097:blood; D001639:Bicarbonates / Q000494:pharmacology; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005316:Fetal Distress / Q000097:blood; D005318:Fetal Heart / Q000502:physiology; D005333:Fetus / Q000502:physiology*; D000882:Haplorhini; D006339:Heart Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007743:Labor, Obstetric; D008252:Macaca fascicularis; D008253:Macaca mulatta; D010100:Oxygen / Q000097:blood*; D010215:Papio; D011247:Pregnancy; D014590:Uterine Contraction
D001639:Bicarbonates; D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen