[Effect of dibasol and ascorbic acid on the antiviral activity of human interferon in cell culture].
The antiviral effect of human lymphocytic interferon was studied in the primary culture of human embryonic fibroblasts in the presence of dibazol and ascorbic acid. It was found that dibazol and ascorbic acid in concentrations of 5 and 10 gamma/ml respectively were capable of increasing the antiviral effect of human interferon in homological cells. The assays of 13 lots of interferon showed that its average titer in the experiments with ascorbic acid was 2.5 times higher than that in the control. The assays of 21 lots of interferon showed that its average titer in the experiments with dibazol was 3 times higher than that in the control. It is suggested that an increase in the protective properties of interferon in the presence of dibazol and ascorbic acid is connected with their capacity for stimulating the intracellular production of DNA and protein. The data obtained indicate that dibazol and ascorbic acid may be recommended in the complex of therapy and prophylaxis of antiviral infections.
D000998:Antiviral Agents; D001205:Ascorbic Acid / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002478:Cells, Cultured; D004347:Drug Interactions; D004357:Drug Synergism; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014776:Virus Cultivation
D000998:Antiviral Agents; D001562:Benzimidazoles; D007372:Interferons; D001205:Ascorbic Acid
Vliianie dibazola i askorbinovĭ kisloty na protivovirusnuiu aktivnost' chelovecheskogo interferona v kul'ture kletok.