Cytogenetic study of the continuous RH cell line and its clones with a different susceptibility to measles virus.
A comparative karyological study was carried out on the RH continuous line of human embryo kidney cells and its 3 clones differing in their sensitivity to the cytopathic effect (CPE) of vaccine measles virus (L-16 strain). The clonal variants studied were shown to have different karyotypes and their sensitivities to be genetically determined. There was a correlation between the rate of appearance and the pattern of the CPE and the percentage of cells in which a set of 33 chromosomes and a high level of polyploidy were combined.
D002460:Cell Line; D002478:Cells, Cultured; D002875:Chromosomes / Q000032:analysis; D002999:Clone Cells; D003588:Cytopathogenic Effect, Viral; D005333:Fetus; D006801:Humans; D007621:Karyotyping; D007668:Kidney; D008459:Measles virus; D008938:Mitosis; D011123:Polyploidy