Preventive effect of diethyldithiocarbamate on experimental diabetes produced by dithisone and 8-oxychinoline.
Diethyldithiocarbamate sodium (DDC)--a compound forming complexes with metal ions-did not change the structure of endocrine pancreas and did not affect the glycemia after the repeated administration of a dose of 250 mg kg-1 while a single dose of 500 or 1000 mg kg-1 increased the glycemia for 2 to 4 h in most of rabbits tested. DDC injected in similar doses prevented a diabetogenic action of dithisone and of a number of 8-oxichinoline derivatives. This effect appeared very rapidly and persisted for several hours being dependent on a dose of DDC and on the interval between its administration and the injection of diabetogenic compounds. It was concluded that DDC forms stable complexes with zinc ions in pancreatic beta-cells which appear to be resistant towards the action of diabetogenic compounds directed selectively to the blocking of zinc ions too and thus to the development of experimental diabetes.
D000818:Animals; D001391:Azo Compounds; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D004230:Dithizone / Q000037:antagonists & inhibitors; D004050:Ditiocarb / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006912:Hydroxyquinolines; D006943:Hyperglycemia / Q000517:prevention & control; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D015125:Oxyquinoline / Q000037:antagonists & inhibitors; D011817:Rabbits; D013859:Thiocarbamates / Q000627:therapeutic use*; D015032:Zinc / Q000037:antagonists & inhibitors / Q000378:metabolism
D001391:Azo Compounds; D006912:Hydroxyquinolines; D013859:Thiocarbamates; D015125:Oxyquinoline; D004230:Dithizone; D004050:Ditiocarb; D015032:Zinc