[Plasma cortisol response to intravenous beta 1-24 corticotropin as related to the fat mass and its topographic localisation (author's transl)].
Plasma cortisol response induced by 2.5 microgram/kg beta 1-24 corticotropin (1 hour infusion) in obese females was not related to fat mass. The response was increasingly pronounced as fat predominated in the upper body segment, i.e. android obesity. This phenomenon may be interpreted as indicating an increased adrenal capacity to secrete cortisol in such obese patients. Low level but longstanding excess cortisol secretion is probably the cause of the android features of obesity.
D000273:Adipose Tissue / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D010446:Peptide Fragments
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Réponse de la cortisolémie a la bêta 1-24 corticotrophine intra-veineuse en fonction de la masse grasse et de sa répartition topographique.