Alterations in the expression of the cytomegalovirus-induced cytopathogenic effect in fibroblasts by aflatoxin B1.
Aflatoxin B1 has been shown both to promote and to alter the expression of the cytopathogenic effect observed when human fibroblasts are challenged with human cytomegalovirus (CMV). Although the cells become round, as is the characteristic effect of this virus on fibroblasts, multinucleate cells are seen to arise from cell fusion within 48 h after virus addition.
D000348:Aflatoxins / Q000633:toxicity*; D002462:Cell Membrane / Q000648:ultrastructure; D002478:Cells, Cultured; D003586:Cytomegalovirus Infections / Q000473:pathology*; D003588:Cytopathogenic Effect, Viral; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning
D000348:Aflatoxins