The effect of alpha-adrenergic stimulation in stress incontinence.
The urethra is innervated by adrenergic fibres and its smooth muscle is equipped mainly with alpha-adrenoreceptors. Norephedrine chloride, which is an alpha-stimulating agent, has been proposed as therapy for stress incontinence, since it was shown to increase the maximum urethral pressure at rest. For further study of the effect of norephedrine chloride on the urethal closure pressure at rest and in a dynamic situation, we examined ten severely stress-incontinent women before and after three weeks of treatment with this agent (100 mg by mouth twice daily). The urethral closure pressure at rest, between coughs of varied strength and at the precise moment of stress were recorded. The margin to leakage, the tone of the urethral wall and the transmission of pressure from abdomen to urethra were also among the estimated factors. No improvement was found in any of these respects. Alpha stimulation in this form therefore seems ineffective in severe stress incontinence and is not an alternative to surgical treatment.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000294:innervation / Q000503:physiopathology; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D011312:Pressure; D011941:Receptors, Adrenergic / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D014521:Urethra / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology; D001743:Urinary Bladder / Q000503:physiopathology; D014550:Urinary Incontinence, Stress / Q000188:drug therapy* / Q000503:physiopathology
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D010665:Phenylpropanolamine