3-Substituted 2-formylquinoxaline 1,4-dioxides.
The methylnitrone of 3-methyl-1,4-dioxidoquinoxaline-2-carboxaldehyde (1) has been exceptional antibacterial activity in vivo. Derivatives of 3-hydroxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde and 3-acetoxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde were prepared. Several of these compounds were found to be antibacterial agents of the same order of activity as I.
D000818:Animals; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000627:therapeutic use; D051379:Mice; D011512:Proteus Infections / Q000188:drug therapy; D011513:Proteus mirabilis; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000627:therapeutic use; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D012484:Salmonella paratyphi B; D013203:Staphylococcal Infections / Q000188:drug therapy
D003497:Cyclic N-Oxides; D011810:Quinoxalines