[The effect of ethylnitrosourea in the activity of the NAD-linked glycero-3-phosphate dehydrogenase in the Vth nerve of developing rats and its relation to myelination and tumour induction (author's transl)].
The activity of NAD-linked L-alpha-glycero-3-phosphate dehydrogenase (E.C. 1.1.1.8.) in the Vth nerve from albino rats treated with a single subcutaneous injection of ethylnitrosourea in the first day of life and from controls was determined biochemically in 10 different age groups ranging from 7 to 70 days. The specific activities of the controls rise rapidly from the 7--35 days of life and remain there after almost at the same level. The activity of the ENU treated animals is significantly lower than that of the controls and reaches only at the age of 63 days the values of the 35 days old untreated animals. About 26% of the activity values of the treated animals are below the lower confidence limit of the controls.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003390:Cranial Nerve Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000201:enzymology; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D051381:Rats; D014276:Trigeminal Nerve / Q000187:drug effects* / Q000201:enzymology
D009607:Nitrosourea Compounds; D009243:NAD; D005993:Glycerolphosphate Dehydrogenase; D005038:Ethylnitrosourea
Der Einfluss von Athylnitrosoharnstoff auf die Aktivität der Nad-abhängigen L-alpha-Glyzerin-3-Phosphatdehydrogenase während der Myelinisierung und Tumorinduktion im N. trigeminus der Ratte.