Cytogenetic analysis of the sensitivity to anti-viral and anti-cell growth activities of human fibroblast interferon in aneuploid human tumor cell lines. Brief report.
The ability of human fibroblast interferon to suppress colony formation and papovavirus T-antigen expression in six human tumor cell lines did not appear to correlate with their content of chromosomes 16 and 21. Additional factors or chromosomes may be involved in the manifestation of interferon action in aneuploid cells.
D000782:Aneuploidy; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002902:Chromosomes, Human, 16-18; D002904:Chromosomes, Human, 21-22 and Y; D003114:Colony-Forming Units Assay; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D009369:Neoplasms; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D007372:Interferons