Identification and evaluation of the contribution of the chemoreflex in the hemodynamic response to intracarotid administration of contrast materials in the conscious dog: comparison with the response to nicotine.
Intracarotid administration of ionic contrast material and nicotine in conscious, unsedated dogs caused similar biphasic reflex responses consisting of initial decreases followed by increases in heart rate and pressures. Both phases were characterized by increases in respiratory amplitude. The initial hypotension was not observed when heart rate was maintained constant. The initial bradycardia was absent after denervation of the carotid body and cholinergic blockade. The tachycardia was attenuated after ligation of the internal carotid artery and beta adrenergic blockade. Hwever, the hypertension persisted after denervation of the carotid body and ligation of the internal carotid artery but was attenuated after alpha adrenergic blockade. Nonionic contrast material caused almost no reflex hemodynamic effects. Like noxious substances such as nicotine, ionic contrast materials cause complex hemodynamic effects as a consequence of actions on the cardiovascular centers of the brain, carotid body chemoreceptors, and chemosensitive tissue in the external carotid circulation.
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D001775:Blood Circulation / Q000187:drug effects; D002339:Carotid Arteries; D002344:Carotid Body / Q000502:physiology; D002628:Chemoreceptor Cells / Q000502:physiology*; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D009538:Nicotine / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D012119:Respiration / Q000187:drug effects
D003287:Contrast Media; D011943:Receptors, Adrenergic, beta; D003974:Diatrizoate Meglumine; D009538:Nicotine