Antilipolytic nature of gut GLI, and mode of action of two highly potent intestinal lipolytic species in birds.
Three major lipolytic factors, termed peaks 1, 2 and 3, according to their elution sequence from Biogel P6 columns, have been identified in duck intestinal extracts. The small molecular weight peaks 2 and 3, were even more lipolytically potent on chick adipocytes than pancreatic glucagon; peak 1, called gut GLI, because of its cross-reactivity in a radioimmunoassay for glucagon, modified the lipolytic activity of peak 2 and pancreatic glucagon. It did so by modifying their capacity to stimulate cyclic AMP production. Peaks 2 and 3 exert their lipolytic effects via different intermediary pathways: only peak 2 induced the formation of cyclic AMP. Insulin in birds is devoid of any antilipolytic activity; this fundamental role may be assumed by gut GLI.
D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002645:Chickens; D000242:Cyclic AMP / Q000378:metabolism; D004372:Ducks / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005934:Glucagon / Q000276:immunology / Q000494:pharmacology*; D005990:Glycerol / Q000378:metabolism; D050356:Lipid Metabolism; D010455:Peptides / Q000276:immunology
D005768:Gastrointestinal Hormones; D010455:Peptides; D003994:Bucladesine; D005934:Glucagon; D000242:Cyclic AMP; D005990:Glycerol