Maternal immunosuppression and cytomegalovirus infection of the fetus.
Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE). Serology showed that maternal CMV infection had been acquired at least four months before pregnancy. Screening for CMV infection in pregnant women receiving immunosuppressive drugs is recommended.
D000328:Adult; D000907:Antibodies, Bacterial; D001379:Azathioprine / Q000009:adverse effects*; D001925:Brain Damage, Chronic / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000209:etiology* / Q000276:immunology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D011239:Prednisolone / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011251:Pregnancy Complications, Infectious / Q000209:etiology* / Q000276:immunology
D000907:Antibodies, Bacterial; D011239:Prednisolone; D001379:Azathioprine