Synthesis and pharmacological activity of 5-substituted 2-(N,N-dialkylaminoethyl)amino- and 2-N-methylpiperazinyl-1,3,4-thiadiazoles.
5-Substituted 2-amino-1,3,4-thiadiazoles were transformed to their corresponding 2-bromo derivatives. The reaction of the 5-substituted 2-bromo-1,3,4-thiadiazoles with N,N-dialkylaminoethylamines or N-methylpiperazine afforded the corresponding amino-1,3,4-thiadiazole derivatives. All prepared compounds displayed antihistaminic, anticholinergic, and norepinephrine-potentiating activities.
D000818:Animals; D004357:Drug Synergism; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008722:Methods; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology
D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D010879:Piperazines; D013830:Thiadiazoles; D009638:Norepinephrine