[Interferon-producing activity of bone marrow cells treated with mRNA for interferon when transplanted to irradiated mice].
Inoculation into irradiated (800--850 r) mice of syngeneic bone marrow cells treated with mRNA for interferon (mRNA-If) obtained from chick cells induced with UV-irradiated Newcastle disease virus was accompanied by the appearance in the blood of the animals of a substance with the properties of interferon, inhibiting the cytopathic effect of vesicular stomatitis virus in chick embryo cells but not in mouse L cells. Chicken interferon was detected in the blood of the experimental animals for 7--10 days after transplantation of mRNA-If-treated cells.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002642:Chick Embryo; D007369:Interferon Inducers / Q000528:radiation effects; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D009522:Newcastle disease virus; D012333:RNA, Messenger / Q000494:pharmacology*; D014185:Transplantation, Isogeneic; D014466:Ultraviolet Rays; D014721:Vesicular stomatitis Indiana virus
D007369:Interferon Inducers; D012333:RNA, Messenger; D007372:Interferons
Interferonprodutsiruiushchaia aktivnost' kletok kostnogo mozga, obrabotannykh iRNK dlia interferona, pri transplantatsii ikh obluchennym mysham.