Gamma-glutamyl transpeptidase, triglycerides, and enzyme induction.
A study conducted on 109 consecutive patients submitted for routine lipid and lipoprotein screening has shown a significant positive association between serum gamma-glutamyl transpeptidase (gamma-GT) activity and the serum triglyceride concentration and between serum gamma-GT activity and the serum pre-beta-lipoprotein concentration. We suggest that these associations may reflect hepatic microsomal enzyme induction in hyperlipidaemic subjects which increases the hepatic content of the rate-limiting enzyme(s) for triglyceride synthesis.
D000368:Aged; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000201:enzymology; D008074:Lipoproteins / Q000097:blood; D008862:Microsomes, Liver / Q000201:enzymology; D011247:Pregnancy; D014280:Triglycerides / Q000096:biosynthesis* / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis* / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D005723:gamma-Glutamyltransferase