Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.
Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005802:Genes, MHC Class II; D005814:Genes, Viral; D006183:H-2 Antigens; D008285:Major Histocompatibility Complex; D051379:Mice; D012087:Reoviridae / Q000235:genetics*; D012088:Reoviridae Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens