Further studies on the adjuvant effect of silica on IgE antibody production in mice.
The effects of amorphous silica (Aerosil) and of aluminium hydroxide on anti-DNP IgE antibody production were studied in Swiss mice preimmunized with Ascaris protein and then challenged 7 days later with DNP-ASC. Aerosil exerted an adjuvant effect especially when it was injected together with the DNP-ASC conjugate. Al(OH)3 had a weaker adjuvant effect than that produced by Aerosil and then only when it was injected with the DNP-ASC conjugate. Al(OH)3 given with Ascaris extract 7 days before complete antigen had an inhibitory effect on the anti-DNP IgE antibody production.
D000276:Adjuvants, Immunologic; D000536:Aluminum Hydroxide / Q000276:immunology; D000818:Animals; D000941:Antigens; D001200:Ascaris / Q000276:immunology; D004140:Dinitrophenols / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D011506:Proteins / Q000276:immunology; D012822:Silicon Dioxide / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D004140:Dinitrophenols; D011506:Proteins; D007073:Immunoglobulin E; D000536:Aluminum Hydroxide; D012822:Silicon Dioxide