title: Development in vitro of cytotoxic lymphocytes against murine cytomegalovirus.
abstract: Lymphocytes cytotoxic for mouse embryo fibroblasts (MEF) infected with murine cytomegalovirus (MCMV) were produced by in vitro culture of "memory" spleen cells with UV-irradiated, MCMV-infected, MEF. Cytotoxic lymphocytes were developed from spleen cells of mice 10 to 240 days after infection with MCMV. The cytotoxic cells carried the theta and Ly 2 antigens, and were H-2 restricted in the recognition of infected target cells.
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000254:growth & development / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology / Q000528:radiation effects; D006183:H-2 Antigens; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D014466:Ultraviolet Rays
chemical_list: D006183:H-2 Antigens