IgM and IgG response to sheep red blood cells in mouse hepatitis virus-infected nude mice.
In nude mice which originally had no ability to respond to sheep red blood cells, an enhanced response to the same antigen with IgM-IgG switching was demonstrated during subacute infection with mouse hepatitis virus. IgM antibody-producing cells in the spleen were detected at days 2 to 6 after the antigen injection and IgG antibody-producing cells appeared at day 6 or later. The secondary IgG response, though not remarkable, was recognized after reinjection of the antigen 10 days after the first injection.
D000818:Animals; D000921:Antibody-Producing Cells; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008819:Mice, Nude; D006517:Murine hepatitis virus
D007074:Immunoglobulin G; D007075:Immunoglobulin M