title: Enzymic reduction of aromatic hydrocarbon epoxides by the microsomal fraction of rat liver.
abstract: 1. The oxidation of aromatic hydrocarbons to arene oxides and the reduction of these oxides to the parent hydrocarbons are both catalysed by enzymes in the microsomal fraction of rat liver. A suggested name for the enzyme concerned in the reduction of these epoxides is 'epoxide reductase'. 2. 'Epoxide reductase' is NADPH-dependent and is inhibited by oxygen. 3. Preliminary investigations suggest that the enzyme is specific for both 'K-region' and 'non-K-region' arene oxides.
mesh_terms: D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D001580:Benzopyrenes / Q000378:metabolism; D002474:Cell-Free System; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D004988:Ethers, Cyclic; D008748:Methylcholanthrene / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010087:Oxides / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013347:Subcellular Fractions
chemical_list: D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D004988:Ethers, Cyclic; D010087:Oxides; D009249:NADP; D008748:Methylcholanthrene; D010088:Oxidoreductases; D010100:Oxygen