Potential for immunization against herpesvirus infections with plasma membrane vesicles.
Virus-free, membrane antigen (MA)-positive plasma membrane vesicles produced from herpesvirus saimiri-infected owl monkey cells were used as immunogens in cotton-top marmosets. Neutralizing antibodies as well as antibodies to MA and HVS-induced LA were induced following immunization of marmosets with these vesicles. Preliminary findings demonstrated that immunized marmosets were significantly less susceptible to tumour induction by HVS than control animals.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000954:Antigens, Surface / Q000008:administration & dosage; D000956:Antigens, Viral / Q000008:administration & dosage*; D002143:Callitrichinae; D002462:Cell Membrane / Q000276:immunology; D002478:Cells, Cultured; D000882:Haplorhini; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000517:prevention & control*; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology*; D007668:Kidney; D010215:Papio; D014412:Tumor Virus Infections / Q000517:prevention & control*
D000914:Antibodies, Viral; D000954:Antigens, Surface; D000956:Antigens, Viral