Bathtub refinisher's lung: an unusual response to toluene diisocyanate.
Immunologic and inhalation challenge studies were performed on a patient engaged in bathtub refinishing who developed systemic and respiratory symptoms suggestive of hypersensitivity pneumonitis temporally related to his occupation. The refinishing process used a catalyst containing toluene diisocyanate, and all clinical features of the disorder were reproduced by challenge. No immunologic mechanism could be identified. A change of occupation resulted in complete relief of symptoms.
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000276:immunology; D003485:Cyanates / Q000009:adverse effects*; D006801:Humans; D007428:Intradermal Tests; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D012129:Respiratory Function Tests; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
D003485:Cyanates; D014051:Toluene 2,4-Diisocyanate