Methods for detecting disulfiram in biologic fluids: application in studies of compliance and effect of divalent cations on bioavailability.
Studies regarding the efficacy of disulfiram in the treatment of alcoholism have not included a method of evaluating compliance to the prescribed regimen. This article outlines current methods used to detect disulfiram in blood, breath, and urine.
D000863:Antacids / Q000494:pharmacology; D001682:Biological Availability; D001944:Breath Tests; D002246:Carbon Disulfide / Q000032:analysis / Q000097:blood / Q000652:urine; D002412:Cations; D004221:Disulfiram / Q000032:analysis* / Q000097:blood; D004050:Ditiocarb / Q000097:blood / Q000652:urine; D004359:Drug Therapy, Combination; D005296:Ferrous Compounds / Q000494:pharmacology; D005965:Glucuronates / Q000032:analysis; D006801:Humans; D008722:Methods; D010349:Patient Compliance
D000863:Antacids; D002412:Cations; D005296:Ferrous Compounds; D005965:Glucuronates; D004050:Ditiocarb; D002246:Carbon Disulfide; D004221:Disulfiram