Cervical cancer cell lines containing herpesvirus markers.
Five epithelioid cell lines were established from invasive cervical carcinoma tissue and were examined for herpes simplex virus (HSV) antigens or virus-induced changes. Immunofluorescence studies with antiserum to an HSV type 2 nonstructural polypeptide detected perinuclear antigens. In these cell lines, concentrations of a membrane fucopeptide that is regularly present in normal cells were reduced to levels similar to those previously observed in virus-transformed cells. One of the cell lines inoculated into athymic mice produced tumors.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D002460:Cell Line; D002467:Cell Nucleus / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D005643:Fucose / Q000032:analysis; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009374:Neoplasms, Experimental / Q000209:etiology; D010455:Peptides / Q000032:analysis / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology*; D002583:Uterine Cervical Neoplasms
D000956:Antigens, Viral; D008565:Membrane Proteins; D010455:Peptides; D005643:Fucose