[Glomerular disease associated with myelofibrosis (author's transl)].
The authors report the case of a 46 year-old patient presenting with membranous-proliferative glomerular disease, megakaryocytes present in the glomerular capillaries, evolving concomitantly with myelofibrosis. There are two possible explanations for this unusual association: the glomerular disease and the myelofibrosis may both result from the same etiologic and pathogenic factor, or the glomerular disease may be the consequence, thrombocytosis existing, of platelet activation, either direct or after deposition of immune complexes. The formation of immune complexes after antigenic stimulation in myelofibrosis is theoretically compatible with immunitary anomalies found in the evolution of this disorder as described in the literature.
D006801:Humans; D007105:Immune Complex Diseases; D007674:Kidney Diseases / Q000150:complications* / Q000276:immunology; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008533:Megakaryocytes; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications* / Q000276:immunology; D013163:Splenomegaly / Q000150:complications* / Q000276:immunology
Glomérulopathie et splénomégalie myéloïde.