Crosslinking and carbohydrate studies on the hydroxylated glycopeptides which accumulate in alveoli and lamellar bodies.
These data suggest that the alveolar lining layer and lamellar body membranes contain the same saline-insoluble proteins, two of which are unusual in that they contain hydroxyproline and large amounts of glycine. Neither the function nor the origin of these glycopeptides has been established, and we are currently evaluating methods of stimulating their production in animals for further study.
D000818:Animals; D003094:Collagen / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006020:Glycopeptides / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D006900:Hydroxylation; D006909:Hydroxyproline / Q000378:metabolism; D008970:Molecular Weight; D011402:Pronase / Q000494:pharmacology; D011649:Pulmonary Alveolar Proteinosis / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011817:Rabbits; D014357:Trypsin / Q000494:pharmacology
D006020:Glycopeptides; D003094:Collagen; D014357:Trypsin; D011402:Pronase; D006909:Hydroxyproline; D005998:Glycine