Relationship between pycnotic indec Qp as a result of oxygen supply and similar indices as a result of in vitro offer of cytochrome c and NADP in psychiatry.
The authors follow up on their previous studies of morphological changes in the properties of white blood cells represented by the oxygen pycnotic index Qp in patients with the schizophrenic syndrome. Several years of research made it obvious to them that this index remains generally unaffected by drugs administered during the treatment although the patient does show a pronounced clinical change. They decided to substitute the offer of oxygen by adding a supply of cytochrome c and NADP, i.e. by substances that give a boost to the oxidoreduction processes within the cell. They found the pycnotic quotient, based on cytochrome c, and - to an even greater degree - the NADP-based quotient to be more responsive to differences in the seriousness of the disease than the oxygen quotient.
D002467:Cell Nucleus / Q000648:ultrastructure*; D003574:Cytochrome c Group / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000648:ultrastructure*; D001523:Mental Disorders / Q000097:blood*; D009249:NADP / Q000494:pharmacology; D010100:Oxygen
D003574:Cytochrome c Group; D009249:NADP; D010100:Oxygen