Comparison of various macrophage-inhibitory agents on vaginal and systemic herpes simplex virus type 2 infections.
Pretreatment of mice intraperitoneally with silica, trypan blue, or dextran sulfate to inhibit macrophage function markedly increased the lethality of a systemic intravenous infection with herpes simplex virus type 2, but did not affect the lethality or local virus growth after vaginal infection of mice with herpes simplex virus type 2. Agents which inhibit macrophage function by different mechanisms decreased host resistance to herpes simplex virus type 2, but the effects of macrophage-inhibitory agents may vary according to the route of virus infection.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D006561:Herpes Simplex / Q000209:etiology*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D012822:Silicon Dioxide / Q000494:pharmacology; D014343:Trypan Blue / Q000494:pharmacology; D014623:Vaginal Diseases / Q000209:etiology*
D003911:Dextrans; D012822:Silicon Dioxide; D014343:Trypan Blue