[Cefoxitin, a new semi-synthetic cephamycin (author's transl)].
The authors review the procedure utilized for the naming of a new antibiotic. The cephamycins are taken as an example. Cefoxitin, derivative of the cephamycin C through an original chemical reaction is described. This antibiotic possesses a high degree of resistance to beta-lactamases due to the presence of a methoxy group in the 7alpha position of the beta-lactam ring. The results of extensive in-vitro trials are given, they indicate that cefoxitin has a unique antibacterial activity.
D001419:Bacteria / Q000187:drug effects / Q000201:enzymology; D002440:Cefoxitin / Q000138:chemical synthesis / Q000494:pharmacology; D002510:Cephalosporinase / Q000378:metabolism; D002511:Cephalosporins / Q000138:chemical synthesis / Q000494:pharmacology; D002513:Cephamycins / Q000266:history; D002621:Chemistry; D004352:Drug Resistance, Microbial; D049673:History, 20th Century; D010405:Penicillinase / Q000378:metabolism
D002511:Cephalosporins; D002513:Cephamycins; D002440:Cefoxitin; D002510:Cephalosporinase; D010405:Penicillinase
La céfoxitine, une céphamycine semi-synthétique.