Pressure, anesthetics, and membrane structure: a spin-probe study.
Fatty acid spin-probe analyses at various depths in the membrane bilayer of intact erythrocytes indicate that compressional effects of pressure and fluidizing effects of lipid-soluble anesthetics are detectable only in hydrated regions of the membrane bilayer. Since current theories of anesthetic action cannot explain these observations, a proposal to do so is outlined.
D000777:Anesthetics / Q000494:pharmacology*; D002725:Chloroform / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology; D006371:Helium / Q000494:pharmacology; D006801:Humans; D006874:Hydrostatic Pressure; D008560:Membrane Fluidity; D008563:Membrane Lipids; D009584:Nitrogen / Q000494:pharmacology; D000442:Octanols / Q000494:pharmacology; D010743:Phospholipids; D011312:Pressure; D013113:Spin Labels
D000777:Anesthetics; D008563:Membrane Lipids; D000442:Octanols; D010743:Phospholipids; D013113:Spin Labels; D006371:Helium; D002725:Chloroform; D009584:Nitrogen; D006221:Halothane