Pharmacological actions of HS-6, an oxime, on the neuromuscular junction.
The effect of HS-6 [1-(2-hydroxyiminomethylpyridinium)-1-(3-carboxamidopyridinium)-dimethyl ether] on neuromuscular (NM) transmission was investigated using chick biventer cervicis (CBC), rat diaphragm (RD) and guinea pig ileum longitudinal muscle strip (GPLS) preparations. In the CBC preparation HS-6 did not cause a contraction, whereas it produced a dose-related contraction of the GPLS preparation. HS-6 produced a hemicholinium-like NM blockade in the CBC and RD preparations. This was supported by the fact that HS-6 inhibited choline uptake in erythrocytes. HS-6 inhibited the contractions of various nicotinic agonists in the CBC preparation and augmented the acetycholine contractions. The latter was due to AChE inhibition produced by HS-6.
D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors; D002417:Cattle; D002645:Chickens; D002794:Choline / Q000097:blood; D002800:Cholinesterase Inhibitors; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects*; D011220:Pralidoxime Compounds / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D011220:Pralidoxime Compounds; C003027:HS 6; D002217:Carbachol; D002794:Choline