Latent infection of cattle with bovid herpesvirus 2.
In a series of experiments, 10 calves were infected by different routes with bovine mammillitis strain of bovid herpesvirus 2 (BHV2). Nine of the calves developed lesions and BHV2 was isolated from 8 calves. At intervals, after clinical recovery, the calves were given a course of corticosteroid by intravenous injection. Subsequently 7 calves developed lesions and from 3 calves BHV2 was reisolated. The shortest interval between initial infection and reisolation of virus was 10 weeks. In one calf virus was recovered on 3 occasions, at intervals of 20, 44 and 74 weeks post-infection. It is probable that BHV2 can occur as a latent infection in calves and that BHV2 should be included among the herpesviruses known to remain latent.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology*; D003907:Dexamethasone / Q000009:adverse effects; D006564:Herpesviridae / Q000254:growth & development*; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D001911:Herpesvirus 2, Bovine / Q000254:growth & development* / Q000302:isolation & purification; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D012611:Scrotum; D012867:Skin / Q000473:pathology; D014779:Virus Replication
D003907:Dexamethasone