Stability studies with amphotericin B and amphotericin B methyl ester.
In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methy ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5 degrees C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.
D000666:Amphotericin B / Q000494:pharmacology; D004355:Drug Stability; D004952:Esters; D006863:Hydrogen-Ion Concentration; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012995:Solubility; D013696:Temperature; D013997:Time Factors
D004952:Esters; D000666:Amphotericin B