[In vitro comparative metabolism of 6,7-3H estrone and 6,7-3H estrone-3-sulfate in maternal and fetal guinea-pig liver].
The metabolism of [6,7-3H] estrone and of [6,7(3)H] estrone-3-sulfate have been comparatively studied in the maternal and fetal guinea-pig livers. The appearance of estradiol-17 beta resulting from the activity of the 17 beta-hydroxysteroid-dehydrogenase is more important in the fetal than in the maternal hepatic tissue. This suggests the direct transformation of estrone-3-sulfate into estradio-3-sulfate in the fetus. After incubation of the [3H] estrone, there is an abundant hepatic conjugation. The glycuroconjugated components are predominant, as well in the maternal as in the fetal hepatic tissue. For the latter-one the sulfoconjugation is inexistant. The sulfatasic activity shown after the incubation of [3H] estrone-3-sulfate is very low in the fetal hepatic tissue; in contrast, this activity is higher in the maternal tissue.
D000818:Animals; D004958:Estradiol / Q000096:biosynthesis; D004966:Estrogens, Conjugated (USP) / Q000378:metabolism; D004970:Estrone / Q000031:analogs & derivatives* / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000196:embryology / Q000378:metabolism*
D004966:Estrogens, Conjugated (USP); D004970:Estrone; D004958:Estradiol; C017296:estrone sulfate
Etude comparée du métabolisme, in vitro, de la [6, 7-3H-A1 estrone et du [6, 7-3H] estrone-3-sulfate par le foie maternel et foetal du cobaye.