title: The clinical evaluation of a new clobetasol propionate preparation in the treatment of otitis externa.
abstract: A new preparation containing clobetasol propionate, tetracycline and nystatin was compared with Otosporin in the the treatment of otitis externa. Thirty-two patients with bilateral disease and seventeen with unilateral disease completed the trial. Signs and symptoms were assessed by the clinician initially and at varying times after treatment. Both preparations were effective in relieving the symptoms with the majority of patients noticing improvement within seven days. Clobetasol propionate ear drops were significantly better than Otosporin when assessed on the patient's last visit to the hospital (p less than 0.05). There were less relapses in the clobetasol propionate group than in the Otosporin group.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001623:Betamethasone / Q000031:analogs & derivatives*; D002648:Child; D002986:Clinical Trials as Topic; D002990:Clobetasol / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000627:therapeutic use; D009761:Nystatin / Q000627:therapeutic use*; D010032:Otitis Externa / Q000188:drug therapy*; D011113:Polymyxins / Q000627:therapeutic use; D011897:Random Allocation; D013752:Tetracycline / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D011113:Polymyxins; D009761:Nystatin; D001623:Betamethasone; D002990:Clobetasol; D013752:Tetracycline; D009355:Neomycin; D006854:Hydrocortisone