Increased brain uptake of copper and zinc in mice caused by diethyldithiocarbamate.
Mice given 64CuCl2 and 65ZnCl2 (10 mumol/kg) were treated with sodium diethyldithiocarbamate (0.5 mmol/kg). The treatment increased the brain level of radioactive copper five-fold and that of radioactive zinc three-fold. Such redistribution of metal ions may be explained from the formation of lipophilic metal chelates. The increased brain levels may involve neurotoxic effects.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002614:Chelating Agents; D003300:Copper / Q000378:metabolism*; D004050:Ditiocarb / Q000494:pharmacology*; D005260:Female; D051379:Mice; D013859:Thiocarbamates / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism*
D002614:Chelating Agents; D013859:Thiocarbamates; D003300:Copper; D004050:Ditiocarb; D015032:Zinc