7S class-restricted hapten-specific paralysis by injection of thymus-independent hapten-carrier conjugate.
The shift from IgM anti-hapten antibody production to IgG anti-hapten antibody production, subsequent to challenge with a T-dependent conjugate, is inhibited in mice by preimmunization with the T-independent DNP-LE conjugate. The results suggest that DNP on levan triggers off 19A T-independent anti-hapten precursors and paralyzes 7S T-dependent anti-hapten precursors.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects; D002352:Carrier Proteins / Q000008:administration & dosage*; D004140:Dinitrophenols / Q000378:metabolism; D006241:Haptens / Q000008:administration & dosage*; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000008:administration & dosage; D013296:Streptococcus pneumoniae / Q000276:immunology; D013451:Sulfonic Acids / Q000008:administration & dosage; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D002352:Carrier Proteins; D004140:Dinitrophenols; D006241:Haptens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011134:Polysaccharides; D013451:Sulfonic Acids