Effects of subinhibitory amounts of ampicillin, amoxycillin and mecillinam on the adhesion of Escherichia coli bacteria to human urinary tract epithelial cells: a preliminary study.
Attachment to mucous surfaces may be a prerequisite for bacteria colonizing these surfaces or invading underlying tissues. Subinhibitory amounts of ampicillin and amoxycillin but not mecillinam decreased the attachment of Escherichia coli bacteria to human uro-epithelial cells in vitro. No significant synergistic effect on the attachment by the antibiotics was obtained. The present report indicates a new parameter for the study of antibacterial actions of drugs.
D000268:Adhesiveness; D000560:Amdinocillin / Q000494:pharmacology; D000658:Amoxicillin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D004357:Drug Synergism; D004848:Epithelium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D010397:Penicillanic Acid / Q000494:pharmacology*; D014551:Urinary Tract / Q000187:drug effects*
D000667:Ampicillin; D000658:Amoxicillin; D010397:Penicillanic Acid; D000560:Amdinocillin