A comparative evaluation of the treatment of typhoid fevers with co-trimoxazole and chloramphenicol in Egypt.
Seventy-two patients with bacteriologically proven enteric fever were treated with either co-trimoxazole (41 cases) or chloramphenicol (31 cases). C0-trimoxazole was found to be superior to chloramphenicol in relieving the toxaemia. The average number of days required for patients to become afebrile was 5-5 days in the co-trimoxazole group and 4-5 days in the chloramphenicol group. The cure rate was 97 per cent in each of the treatment groups. There occurred two relapses in the co-trimoxazole group and four relapses in the chloramphenicol group. No side effects of the co-trimoxazole were detected during the study. Co-trimoxazole can be considered as a good alternative to chloramphenicol in the treatment of the enteric fevers.
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D004534:Egypt; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D012482:Salmonella paratyphi A / Q000302:isolation & purification; D012485:Salmonella typhi / Q000302:isolation & purification; D012547:Schistosoma / Q000302:isolation & purification; D012552:Schistosomiasis / Q000150:complications; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*; D014435:Typhoid Fever / Q000188:drug therapy*; D014556:Urine / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D002701:Chloramphenicol; D014295:Trimethoprim; D013420:Sulfamethoxazole