L-glutamate specific [3H]kainic acid binding in the rat neostriatum after degeneration of the cortico-striatal pathway.
Four weeks after lesion of the cortico-striatal pathway, the specific kainic acid binding was reduced by 20% in the neostriatum. It is concluded that the binding sites are most likely not located on cortico-striatal neurons. The displacement of kainic acid by some chemical indicates that the kainic acid binding site is different from the glutamate binding site, as defined iontophoretically.
D000818:Animals; D001665:Binding Sites; D001931:Brain Mapping; D003342:Corpus Striatum / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D007608:Kainic Acid / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D011759:Pyrrolidines / Q000378:metabolism*; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism
D005971:Glutamates; D011759:Pyrrolidines; D017981:Receptors, Neurotransmitter; D007608:Kainic Acid