[The role of cyclic adenosine 3':5'-monophosphate as "second messenger" in gastric acids secretion (author's transl)].
The criteria to determine whether cyclic adenosine 3':5'-monophosphate (cyclic AMP) is or is not involved in a particular hormone response require to look for positive qualitive, quantitative and temporal correlations between the effects of the hormone on cyclic AMP levels and the physiological response. These requirements have been shown to be fulfilled in histamine and pentagastrin-stimulated gastric acid secretion of the frog (Necturus maculosus) and the rat. In dog and man, however, the available evidence does not support a role for cyclic AMP in the gastric secretory process; it remains a challenge for future research whether in those species cyclic guanosine 3':5'-monophosphate acts as an intracellular substitute for cyclic AMP.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001001:Anura; D002463:Cell Membrane Permeability; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D010418:Pentagastrin / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013045:Species Specificity; D013268:Stimulation, Chemical; D014970:Xanthines / Q000494:pharmacology
D005938:Glucocorticoids; D014970:Xanthines; D006632:Histamine; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D010418:Pentagastrin
Zur Bedeutung des cyclischen Adenosin-3':5'-monophosphat als "second messenger" bei der S-5aaturesekretion des Magens