Apomorphine-like effect of an aminotetralin on the linguomandibular reflex of the cat.
Low doses of 5,6-dihydroxy-2-dimethylaminotetralin (M-7) produced inhibition of the linguomandibular reflex in the cat. This inhibition was similar to that produced by apomorphine and was blocked by haloperidol, bulbocapnine or chlorpromazine. M-7 also had a brief but marked hypertensive effect. Gradual bradycardia also developed. These results indicate that M-7 inhibits the linguomandibular reflex by interaction at dopamine receptors, or 'apomorphine' receptors.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001060:Aporphines / Q000494:pharmacology; D002415:Cats; D002746:Chlorpromazine / Q000494:pharmacology; D003864:Depression, Chemical; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008334:Mandible / Q000502:physiology; D009284:Naphthols / Q000494:pharmacology*; D011955:Receptors, Drug; D012018:Reflex / Q000187:drug effects*; D014059:Tongue / Q000502:physiology
D001060:Aporphines; D009284:Naphthols; D011955:Receptors, Drug; C009957:5,6-dihydroxy-2-dimethylaminotetralin; D006220:Haloperidol; D001058:Apomorphine; D002746:Chlorpromazine; D004298:Dopamine