title: In vitro effect of transfer factor on the cyclic nucleotide level of human lymphocytes in chronic lymphocytic leukaemia and of mouse lymphocytes.
abstract: In the present study transfer factor (TF) failed to produce any change in the cAMP- and cGMP-levels of lymphocytes of patients with chronic lymphoid leukaemia (CLL). This is attributed to the malignant transformation of the lymphocytes or to a changed proportion of different lymphocyte populations in CLL. Human TF leaves the cyclic nucleotide levels of splenic lymphocytes of BALB/c mice unaffected.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000097:blood; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009712:Nucleotides, Cyclic / Q000097:blood*; D013601:T-Lymphocytes / Q000378:metabolism; D014165:Transfer Factor / Q000494:pharmacology*
chemical_list: D009712:Nucleotides, Cyclic; D014165:Transfer Factor; D000242:Cyclic AMP