[Carcinogenic effect, on the liver, of an insecticide: aramite (author's transl)].
Aramite has been administered to male rats by oral route during 56 weeks at a daily dose of 400 mg/kg. There was a decrease of the body weight and several animals died. Liver hypertrophy was observed with neoplasic proliferation of parenchymatous cells and cholangiocarcinoma.
D000476:Alkanesulfonates / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010647:Phenyl Ethers / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000476:Alkanesulfonates; D002273:Carcinogens; D007306:Insecticides; D010647:Phenyl Ethers; C004872:sulfurous acid, 2-(p-tert-butylphenoxy)-1-methylethyl 2-chloroethyl ester
Démonstration et modalités de l'action cancérogène hépatique d'un insecticide, l'aramite, chez le rat.