[Comparison of the haemodynamic effects in man of the beta-adrenergic blocking substances Kö 1366 and practolol (author's transl)].
In 21 healthy male persons haemodynamic changes (heart rate, end-diastolic pulmonary artery pressure, training condition of heart, a so-called index of heart sufficiency and arterial blood pressure) at rest and during dynamic exercise were compared respectively before and after i.v. injection of 0.0375 mg/kg of the beta-adrenergic blocking drug K+5Ao 1366 [O-(2-hydroxy-3-(tert. butylamino)-propoxy)-benzonitril-hydrochloride], of 0.3 mg/kg practolol [4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide] and a placebo. According to the analysed parameters Kö 1366 has an essentially better beta-adrenergic blocking potency than practolol. Neither of the two substances has a negative inotropic effect or influences the arterial blood pressure.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011217:Practolol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011412:Propanolamines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced
D011412:Propanolamines; D011217:Practolol
Vergleichende funktionsanalytische Untersuchungen der beta-adrenolytischen Substanzen Kö 1366 und Practolol