title: Changes in psychological well-being during postmenopause as a result of estrogen therapy.
abstract: A study of the effects of a conjugated estrogen (Femipren) upon various climacteric symptoms, depression and anxiety scores and psycho-social factors in 120 women around the menopause, was carried out in a Menopause Clinic. In order to participate in this study, the women had to meet very strict criteria. A climacteric symptom list, the MMPI and a psycho-social questionnaire were used for assessment, and were employed before, during and at the end of 1 yr of hormone replacement therapy. Typical vasomotor and psychic symptoms changed significantly as did such factors as self-image, optimism, perception of the future and satisfaction with personal appearance, in those patients who received hormonal replacement therapy for 1 yr. As the psychological factors changed only in those patients who received long-term estrogen therapy, a tentative hypothesis of direct psychotropic effect of estrogen was formulated.
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004651:Employment; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008950:MMPI; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D010549:Personal Satisfaction; D010919:Placebos; D011584:Psychology
chemical_list: D004966:Estrogens, Conjugated (USP); D010919:Placebos