Presence of tolyl-specific IgE and absence of IgG antibodies in workers exposed to toluene diisocyanate.
Independent immunoenzymatic and radioimmunoassay techniques indicated the absence of tolyl-specific IgG antibodies in sera from 25 workers with long-term exposure to toluene diisocyanate (TDI). Five of these workers were clinically hypersensitive to TDI and displayed significant titers of tolyl-specific IgE antibodies in their sera.
D003485:Cyanates / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D009784:Occupational Diseases / Q000139:chemically induced*; D011863:Radioimmunoassay; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects / Q000276:immunology*
D003485:Cyanates; D007074:Immunoglobulin G; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E