[Carbohydrate metabolism enzymatic activity and its alteration under the influence of thyroid hormone during tumor growth].
The activity of hexokinase (HK), its isoenzymes, glucose-6-phosphatase and glucose-6-phosphate dehydrogenase, and the triiodothyronine (T3) effect on this activity in the liver tissue of mice bearing transplantable hepatoma 22a were studied in different periods of the tumor growtn. It was shown that alterations in the activity of the enzymes in the liver of tumor-bearing mice occurred already in the presence of a small tumor. More profound alterations in the activity of all enzymes studied, apart from those in the enzymatic pattern of HK, could be observed starting from day 21after the tumor transplantation. In the initial stages of the hepatoma growth the activity of the test enzymes in the liver was regulated by thyroid hormone. The effect of Ta on the activity of the enzymes in the host liver was gradually lost in the course of the tumor growth.
D000818:Animals; D050260:Carbohydrate Metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D013963:Thyroid Hormones / Q000494:pharmacology*; D013997:Time Factors
D007527:Isoenzymes; D013963:Thyroid Hormones; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D005952:Glucose-6-Phosphatase
Aktivnost' fermentov uglevodnogo obmena i ee izmenenie pod vliianiem tireoidnogo gormona pri opukholevom roste.