title: Aplasia and leukaemia following chloroquine therapy.
abstract: Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed three weeks after ingestion of the drug. The mechanism(s) of chloroquine-induced marrow injury is not known. A parallel to chloramphenicol-induced blood dyscrasias is drawn, but remains unproved.
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D001853:Bone Marrow / Q000473:pathology; D002738:Chloroquine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008288:Malaria / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
chemical_list: D002738:Chloroquine
references.citation: Prog Hematol. 1964;4:138-59
references.pmid: 14272794
references.citation: Med J Aust. 1965 Feb 13;1(7):217-9
references.pmid: 14260276
references.citation: Br Med J. 1957 Jun 1;1(5030):1286-7
references.pmid: 13426608
references.citation: N Engl J Med. 1967 Dec 7;277(23):1241-52
references.pmid: 4168399
references.citation: Am J Med. 1973 Jul;55(1):38-48
references.pmid: 4515079
references.citation: N Engl J Med. 1967 Aug 31;277(9):492-3
references.pmid: 6071835