Host specificity of a serum marker for hepatitis B: evidence that "e antigen" has the properties of an immunoglobulin.
A family of antigens, referred to collectively as e antigen (eAg), has been detected in sera of some individuals with liver disease who test positive for hepatitis B surface antigen. Studies on eAg partially purified by affinity chromatography on insolubilized antibodies to eAg revealed the following: (i) eAg has the physicochemical and immunologic properties of an immunoglobulin, predominantly of the IgG4 subclass, and (ii) specific antigenic sites, designated as e determinants, differentiate eAg from other immunoglobulins. We suggest that these determinants represent idiotypic determinants on antibodies that are formed in response to hepatitis B virus infection and that block the host's immune surveillance mechanisms by which virus proliferation is stopped.
D002846:Chromatography, Affinity; D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G; D007525:Isoelectric Focusing; D008970:Molecular Weight
D006511:Hepatitis B Antigens; D007074:Immunoglobulin G
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