Cooperativity in O2 binding to iron porphyrins.
The solid-gas O2 binding equilibrium has been studied for for ferrous "picket fence" porphyrinates with sterically hindered axial imidazoles. Such systems show significant cooperativity in their binding of O2: at low O2 pressures a low O2 affinity form exists, and at high O2 pressures a higher O2 affinity form develops. Direct analogies are drawn to the cooperativity shown in O2 binding by hemoglobin. These model systems mimic hemoglobin quantitatively.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007501:Iron; D007700:Kinetics; D010100:Oxygen; D010108:Oxyhemoglobins; D011166:Porphyrins
D010108:Oxyhemoglobins; D011166:Porphyrins; D007501:Iron; D010100:Oxygen
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