Factors influencing tone in rabbit large intestine.
Pressure/volume curves obtained in the presence of papaverine have been compared with those obtained under control conditions in rabbit large intestine. Tension/length curves obtained on stimulation of the extrinsic nerve supply to the intestine have been compared with control curves. Evidence is presented for a small contribution of sustained muscular activity to the pressue/volume and tension/length curves. The effect of stretch on peak tension attained by the intestine has also been examined.
D000818:Animals; D005260:Female; D007420:Intestine, Large / Q000502:physiology*; D007461:Iodoacetates / Q000494:pharmacology; D008297:Male; D009129:Muscle Tonus; D009130:Muscle, Smooth / Q000502:physiology*; D010208:Papaverine / Q000494:pharmacology; D010507:Periodicity; D010812:Physical Stimulation; D011817:Rabbits; D013779:Tetrodotoxin / Q000494:pharmacology
D007461:Iodoacetates; D013779:Tetrodotoxin; D010208:Papaverine