title: [In vivo studies on the effect of alpha chymotrypsin on hemostasis].
abstract: In some cases we observed after-bleeding subsequent to the postoperative prescription of alpha-chymotrypsin. In contrast to this, several authors have pointed out that haemostasis is not affected by therapeutical doses. In vitro studies on 10 individuals (test methods: hirudin tolerance test and euglobulin lysis estimation) showed increased fibrinolytic activity. It is, therefore, dissuaded from administering alpha-chymotrypsin to outpatients for the prevention of postoperative oedema and haematoma formation.
mesh_terms: D002918:Chymotrypsin / Q000494:pharmacology*; D004487:Edema / Q000517:prevention & control; D005342:Fibrinolysis / Q000187:drug effects; D006406:Hematoma / Q000517:prevention & control; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008963:Molar; D014081:Tooth Extraction
chemical_list: D002918:Chymotrypsin
vernacular_title: In-vivo-Untersuchungen zur Beeinflussung der Hämostase durch alpha-Chymotrypsin