Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women.
The female germ cell stage of primary importance in radiation genetic hazards is the immature, arrested oocyte. In the mouse, this stage has a near zero or zero sensitivity to mutation induction by radiation. However, the application of these mouse results to women has been questioned on the ground that the mouse arrested oocytes are highly sensitive to killing by radiation, while the human cells are not; and, furthermore, that the mature and maturing oocytes in the mouse, which are resistant to killing, are sensitive to mutation induction. The present results have a 2-fold bearing on this problem. First, a more detailed analysis of oocyte-stage sensitivity to killing and mutation induction shows that there is no consistent correlation, either negative or positive, between the two. This indicates that the sensitivity to cell killing of the mouse immature oocyte may not be sufficient reason to prevent its use in predicting the mutational response of the human immature oocyte. Second, if the much more cautious assumption is made that the human arrested oocyte might be as mutationally sensitive as the most sensitive of all oocyte stages in the mouse, namely the maturing and mature ones, then the present data on the duration of these stages permit more accurate estimates than were heretofore possible on the mutational response of these stages to chronic irradiation.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005787:Gene Frequency; D006801:Humans; D051379:Mice; D009154:Mutation / Q000528:radiation effects*; D011831:Radiation Genetics; D012044:Regression Analysis; D012737:Sex Factors; D013045:Species Specificity
Proc Natl Acad Sci U S A. 1959 Jan;45(1):18-23
16590349
Br J Radiol. 1958 Aug;31(368):407-11
13560745
Cold Spring Harb Symp Quant Biol. 1951;16:327-36
14942747
Nature. 1976 Dec 23-30;264(5588):715-9
1034880
Mutat Res. 1974 Aug;24(2):171-86
4851248
Mutat Res. 1975 Nov;33(1 Spec No):95-102
1202345
Mutat Res. 1975 Dec;30(3):375-82
1202329
Mutat Res. 1975 Jun;28(3):421-36
1169684
Proc Natl Acad Sci U S A. 1965 Dec;54(6):1552-7
5218911
Br J Radiol. 1969 Jun;42(498):448-51
5810857