title: Collagenolysis by human gingival fibroblast cell lines.
abstract: Human gingival fibroblast cell lines were initiated in flask cultures from four periodontal patients with the diagnoses of periodontitis (two patients), fibromatosis, and Dilantin hyperplasia. The collagenolytic propensity of these fibroblasts cultivated on collagen-coated cover slips and the inhibitory effect of serum were evaluated by direct microscopic observations.
mesh_terms: D002460:Cell Line; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D005351:Fibromatosis, Gingival / Q000378:metabolism; D005881:Gingiva / Q000378:metabolism*; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000378:metabolism; D006801:Humans; D010518:Periodontitis / Q000378:metabolism; D010672:Phenytoin / Q000009:adverse effects
chemical_list: D010672:Phenytoin; D003094:Collagen