Independent expression of the adrenergic phenotype by neural crest cells in vitro.
Neural crest cells obtained from Japanese quail and grown in vitro without other embryonic tissues differentiate into adrenergic cells. These cells show intense catecholamine-specific histochemical fluorescence, and some have long, varicose neuronal processes. Ultrastructural examination shows two populations of cells, one with small (about 90 nm) dense-core vesicles resembling principal sympathetic neurons and the other with larger (about 150 nm) dense-core granules resembling chromaffin or small intensely fluorescent cells. Neuronal cells without adrenergic characteristics are also present. These results are compatible with the hypothesis that a population of cells determined along neuronal lines exists in the neural crest prior to migration.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002454:Cell Differentiation; D002838:Chromaffin System / Q000196:embryology* / Q000648:ultrastructure; D003370:Coturnix; D004477:Ectogenesis; D005725:Ganglia, Autonomic / Q000196:embryology* / Q000648:ultrastructure; D008544:Melanocytes / Q000166:cytology; D009420:Nervous System / Q000196:embryology*; D010641:Phenotype
D002395:Catecholamines
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4225-9
186792
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4220-4
1069311
Brain Res. 1972 Nov 13;46:159-75
4117873
Dev Biol. 1974 Nov;41(1):162-84
4140118
J Neurochem. 1974 Feb;22(2):301-6
4151460
Brain Res. 1971 Nov;34(2):229-40
4401209
Pharmacol Rev. 1972 Jun;24(2):255-67
4404612
J Neurocytol. 1974 Aug;3(3):363-84
4373543
J Cell Biol. 1973 Apr;57(1):88-108
4347980
Nature. 1976 Jul 22;262(5566):308-10
183125
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3607-10
4279409
J Biol Chem. 1966 May 25;241(10):2301-5
4287854
Z Zellforsch Mikrosk Anat. 1972;135(3):287-314
4566367
Brain Res. 1976 Feb 6;102(2):301-12
2367
J Cell Biol. 1972 May;53(2):348-64
4554365
Histochem J. 1972 Jan;4(1):49-58
4553247
Exp Neurol. 1974 Oct;45(1):94-103
4472205
J Cell Biol. 1976 Feb;68(2):240-63
173724
Dev Biol. 1973 Sep;34(1):16-38
4787602
J Anat. 1973 May;115(Pt 1):119-31
4728263
J Exp Zool. 1972 Feb;179(2):167-82
5059187
Anat Embryol (Berl). 1975 May 16;146(3):225-43
1096675
Brain Res. 1976 Sep 24;114(3):391-414
953763
Cell Tissue Res. 1976 Jan 28;165(4):477-508
1260841
Dev Biol. 1976 Mar;49(1):66-79
1254098
J Neurocytol. 1975 Dec;4(6):633-46
1238511
Dev Biol. 1975 Oct;46(2):262-80
1183721
Dev Biol. 1975 Jan;42(1):106-30
1112437
Dev Biol. 1971 Dec;26(4):578-605
5134613
J Anat. 1969 Sep;105(Pt 2):255-82
5802933
Acta Neuroveg (Wien). 1967;30(1):427-44
6080700