title: Quantitative correlation of dopamine-dependent adenylate cyclase with responses to levodopa in various mice.
abstract: We obtained 12 groups of mice with widely different neurological responses to levodopa by selecting them from different strains and submitting some of them to pretreatments. We scored the symptoms evoked by a standardized dose of levodopa in one subgroup from each group. We tested another subgroup for activation of an adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] by a standardized dose of dopamine added to homogenates of the caudate nuclei of the brains of these mice. Both sets of tests were performed randomly. When the accruing two sets of data were plotted against each other there emerged a straight line which fitted the data with a coefficient of correlation of 0.97 (P less than 0.0001). The dopamine-dependent activity of the adenylate cyclase of the brain was thus shown to be a determinant of the neurological responses of intact animals to a dopaminergic drug.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002421:Caudate Nucleus / Q000201:enzymology*; D004298:Dopamine / Q000494:pharmacology*; D004789:Enzyme Activation; D005260:Female; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D051379:Mice
chemical_list: D007980:Levodopa; D000262:Adenylyl Cyclases; D004298:Dopamine
references.citation: Proc Natl Acad Sci U S A. 1974 Jul;71(7):2915-8
references.pmid: 4527668
references.citation: Proc Natl Acad Sci U S A. 1974 Apr;71(4):1113-7
references.pmid: 4151517
references.citation: J Neurochem. 1974 Feb;22(2):265-70
references.pmid: 4829953
references.citation: Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9
references.pmid: 4403305
references.citation: Proc Natl Acad Sci U S A. 1974 Sep;71(9):3350-4
references.pmid: 4372616
references.citation: Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12
references.pmid: 4318781
references.citation: Neurosci Res (N Y). 1973;5(0):97-108
references.pmid: 4276183
references.citation: Science. 1976 Aug 20;193(4254):683-5
references.pmid: 181842
references.citation: J Neurochem. 1975 Aug;25(2):143-9
references.pmid: 237983
references.citation: Science. 1972 Apr 28;176(4033):410-2
references.pmid: 5026160
references.citation: Science. 1975 Jun 20;188(4194):1217-9
references.pmid: 1145194