The binding of theophylline to serum proteins of hemodialysis patients.
The binding of theophylline to serum proteins was studied by 18 hour equilibrium dialysis at 37 degrees C in serum from 10 chronic dialysis patients and 6 healthy subjects. The healthy subjects had a mean (+/- S.D.) unbound fraction of 54 +/- 5% while the dialysis patients had 63 +/- 5% unbound (p less than 0.02). For dialysis patients to achieve the same theophylline concentration in plasma water that metabolically normal asthmatics achieve at the "therapeutic" serum theophylline levels of 10-20 micrograms/ml, their total serum theophylline levels should be 8.6-17.3 micrograms/ml.
D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis; D013806:Theophylline / Q000097:blood / Q000378:metabolism*
D001798:Blood Proteins; D012709:Serum Albumin; D013806:Theophylline