title: The effect of an alexidine mouthwash on dental plaque and gingivitis.
abstract: The alexidine mouthrinse used in this study (CP-101) is effective in reducing plaque. There was a reduction in gingivitis after 6-months use but not at a statistically significant level. An extrinsic brown stain occurred at a significant level on the teeth of participants using the active mouthrinse. Blood and urine laboratory results indicated that alexidine can be safely used over a 6-month period.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001645:Biguanides / Q000009:adverse effects / Q000627:therapeutic use*; D003116:Color; D003773:Dental Plaque / Q000517:prevention & control*; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D014060:Tongue Diseases / Q000139:chemically induced; D014075:Tooth Discoloration / Q000139:chemically induced
chemical_list: D001645:Biguanides; D009067:Mouthwashes; D010919:Placebos; C001570:alexidine