title: X-ray response of Chinese hamster ovary cells during the latter part of G2.
abstract: The ability of Chinese hamster ovary (CHO) cells to repair x-radiation damage during the transit from the late G2 to early M cell cycle stages was investigated by conventional dose-fractionation techniques. Despite their relatively high radiation sensitivity, CHO cells positioned in late G2 exhibit increased survival when a given dose of ionizing radiation is administered as two fractions (separated by 40-50 min) instead of as a single fraction. This increased survival apparently represents repair since neither cell cycle progression nor changes in the number of "effective targets" can account for the observed dose-sparing effect.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007399:Interphase; D010053:Ovary / Q000166:cytology / Q000528:radiation effects*; D014965:X-Rays
references.citation: Biophys J. 1963 Sep;3:379-97
references.pmid: 14062457
references.citation: Exp Cell Res. 1963 Apr;30:344-62
references.pmid: 13980637
references.citation: Exp Cell Res. 1963 Feb;29:515-26
references.pmid: 13952250
references.citation: Radiat Res. 1978 Sep;75(3):607-16
references.pmid: 724989
references.citation: Proc Natl Acad Sci U S A. 1978 May;75(5):2378-81
references.pmid: 209462
references.citation: Mol Gen Genet. 1978 Jul 4;162(3):277-86
references.pmid: 355834
references.citation: Nature. 1978 Feb 23;271(5647):713-7
references.pmid: 342976
references.citation: Biophys J. 1978 Jul;23(1):71-8
references.pmid: 667307
references.citation: J Theor Biol. 1978 Apr 6;71(3):339-46
references.pmid: 642534
references.citation: Radiat Res. 1966 Nov;29(3):413-32
references.pmid: 4224300
references.citation: Radiat Res. 1968 Mar;33(3):620-43
references.pmid: 4867897
references.citation: Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Sep;26(3):289-95
references.pmid: 4547759
references.citation: Curr Top Radiat Res Q. 1972 Jul;8(1):39-43
references.pmid: 4678087
references.citation: Int J Radiat Biol Relat Stud Phys Chem Med. 1970;17(1):61-79
references.pmid: 5309093
references.citation: Radiat Res. 1976 Mar;65(3):511-28
references.pmid: 1265214
references.citation: Biophys J. 1976 Apr;16(4):303-18
references.pmid: 1252583
references.citation: Methods Cell Biol. 1975;9(0):85-101
references.pmid: 1169680