The effect of arachidonic acid on the response of the isolated liver to hypoxia.
Arachidonic acid, the precursor molecule of the bisenoic series of prostaglandins, was investigated for its ability to modify the response of isolated perfused livers to hypoxia. Rabbit livers were perfused at a constant rate of flow with Krebs-Henseleit bicarbonate buffer for two hours following the initiation of severely hypoxic conditions. This procedure resulted in significant increases in the wet weight of the liver, and also resulted in the release of intracellular enzymes into the perfusion medium. These changes were significantly attenuated in hypoxic livers receiving arachidonic acid during the two-hour perfusion period. Results of this study suggest that arachidonic acid may be of value in its ability to maintain cellular integrity during periods of cellular hypoxia.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology / Q000503:physiopathology*; D008102:Liver Circulation; D009929:Organ Size; D010101:Oxygen Consumption; D011817:Rabbits
D001095:Arachidonic Acids