The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.
The electronic properties of a series of N,N-dimethyltryptamines and related analogs, for which binding affinity data are available, were examined using both a pi-electron and an all-valence electron method. The results suggest that affinity is related to the ability of these compounds to donate electrons in a localized charge transfer manner from the 4-position of the indole nucleus.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004563:Electrochemistry; D007211:Indoles; D008968:Molecular Conformation; D004130:N,N-Dimethyltryptamine / Q000031:analogs & derivatives / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D014363:Tryptamines / Q000378:metabolism*
D007211:Indoles; D011985:Receptors, Serotonin; D014363:Tryptamines; D004130:N,N-Dimethyltryptamine