The hippocampus and stress induced 17-OHCS elevations.
The physiologic contribution of the limbic brain to emotionally induced stress is still poorly understood. The present study is designed to more specifically evaluate the role of the hippocampus in stress induced plasma 17-OHCS elevations. The conditional reflex to a sequential presentation of tone and shock was used as the stress agent in adult mongrel dogs. Plasma 17-OHCS levels were determined by the Porter-Silber method. Control and stress levels of 17-OHCS were determined before and after unilateral (left) hippocampectomy, and subsequent contralateral (right) hippocampectomy. A unilateral posterior hippocampal lesion partially attenuated (20%) the normal 17-OHCS stress response. In contrast to unilateral lesions, equivalent bilateral posterior hippocampal lesions abolished the normal 17-OHCS stress response. These observations support the thesis that the elevated 17-OHCS levels in response to the conditioning paradigm is dependent on the hippocampus. Furthermore, it is dependent upon the continuity of the hippocampal circuit and not upon the volumetric steroid binding capacity of the hippocampus. These studies also suggest that a unilaterally functioning hippocampus may be adequate to meet the physiologic needs of stress, as reflected by the 17-OHCS response.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000818:Animals; D004285:Dogs; D006624:Hippocampus / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*
D015062:11-Hydroxycorticosteroids
J Neurophysiol. 1953 May;16(3):324-40
13053249
Endocrinology. 1961 Dec;69:1080-4
13913951
J Neurophysiol. 1961 Jul;24:391-400
13693311
Neuroendocrinology. 1976;20(1):68-78
934426
Neuroendocrinology. 1975;18(2):154-60
1172607
Pharmacol Rev. 1962 Sep;14:317-445
14017298
Isr J Med Sci. 1975 May;11(5):493-5
808515
Neuroendocrinology. 1976;22(1):1-7
1025483
Neuroendocrinology. 1975;18(4):359-65
175313
Neuroendocrinology. 1971;7(1):11-5
5543244
Acta Physiol Acad Sci Hung. 1968;34(1):1-8
4303088
Horm Res. 1976;7(1):56-60
1002117
Acta Physiol Acad Sci Hung. 1961;20:293-7
13892267
Neuroendocrinology. 1978;25(5):303-9
565880
Science. 1966 Aug 12;153(3737):767-8
5940897
Surg Forum. 1960;11:383-5
13683516
Exp Brain Res. 1966;1(2):184-94
4287424
Am J Physiol. 1959 Jan;196(1):44-8
13617434
Brain. 1966 Mar;89(1):83-108
5910903
Physiol Behav. 1971 Nov;7(5):727-32
5164364
Neuroendocrinology. 1968;3(6):337-48
4304308
Can J Physiol Pharmacol. 1972 Apr;50(4):364-7
4556776
Acta Endocrinol (Copenh). 1975 Dec;80(4):625-9
1242575
Behav Biol. 1976 Apr;16(4):515-20
986810
J Neurochem. 1972 Dec;19(12):2737-45
4652626
Am J Physiol. 1961 Aug;201:337-40
13755975
Neuroendocrinology. 1973-1974;13(1):29-40
4779046
Neuroendocrinology. 1973;11(3):191-6
4349362
Neuroendocrinology. 1968;3(6):349-54
4304309
Surg Forum. 1957;8:546-9
13529678
Physiol Behav. 1977 Jun;18(6):1075-83
928530