title: Evaluation of the Gambro Lundia Major 1.36 m2 disposable parallel plate dialyzer.
abstract: The Gambro Lundia Major 1.36 m2 dialyzer was assessed in vivo in ten hemodialysis patients. Urea and creatinine clearances (measured as whole blood values at 60 minutes with a blood flow rate of 200 ml/minute) were 166 +/- 8 m/minute (mean +/- standard error of the mean, n = 9) and 115 +/- 4 ml/minute (n = 11). The creatinine clearance is 15% lower than in vitro data. There was a marked decrease in urea and creatinine clearance with third use of the dialyzer. The ultrafiltration rate was 490 ml/hour/100 mmHg. The priming volume was 125 ml (at a transmembrane pressure of 100 mmHg) and residual blood volume in the dialyzer was 0.57 +/- 0.11 ml (n = 5). The handling, storage and ease of disposal of the dialyzer is better than previous models and its performance characteristics are clinically acceptable.
mesh_terms: D000328:Adult; D001769:Blood; D001810:Blood Volume; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007688:Kidneys, Artificial; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism
chemical_list: D014508:Urea; D003404:Creatinine