[Anaemia with medullary myeloblastosis (author's transl)].
A case of refractory anaemia with medullary myeloblastosis (RAMM) is described. RAMM is a very rare disease and its relationship to aplastic anaemia and smouldering leukaemia is not clearly established. The diagnosis is confirmed by evaluation of the bone-marrow aspirate and ferrokinetic studies which demonstrate ineffective erythropoiesis. The disease is combined with leucopenia, thrombocytopenia and a hyperplastic bone-marrow. Our patient was monitored for 18 months, during which time her haematological findings remained stable. Since transformation into acute leukaemia occurs in about 25% of the cases, a bone-marrow culture study was performed in order to determine such a leukaemic transformation which is not detectable on examination by the light microscope. Culture studies are discussed along with some prognostic, therapeutic and pathophysiological problems of RAMM.
D000368:Aged; D000632:Aminopyrine / Q000009:adverse effects / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001856:Bone Marrow Examination; D004338:Drug Combinations; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D010653:Phenylbutazone / Q000009:adverse effects / Q000627:therapeutic use
D004338:Drug Combinations; D000632:Aminopyrine; D010653:Phenylbutazone
Refraktäre Anämie mit medullärer Myeloblastose.