Involvement of histone H1 in the organization of the chromosome fiber.
At high ionic strength (e.g., physiological salt concentrations) chromosome fibers are 200 A in diameter and composed of discrete globular structures that are held together by histone H1. At low ionic strength the fibers unfold and appear as the familiar chains of nucleosomes (80 A in diameter). The unfolding of chromosome fibers occurs within a narrow salt range. It results from a change in the mode of the interaction between histone H1 and the chromosome fiber and is very likely the consequence of a change from cooperative binding between histone H1 and DNA to a noncooperative binding. In the noncooperative binding state histone H1 molecules are randomly redistributed along the chromosome fiber.
D000818:Animals; D001665:Binding Sites; D002875:Chromosomes / Q000378:metabolism / Q000648:ultrastructure*; D006657:Histones / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D008970:Molecular Weight; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000494:pharmacology
D006657:Histones; D012965:Sodium Chloride
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