title: Fluoride concentrations in saliva after single oral doses and their relation to plasma fluoride.
abstract: The saliva and plasma fluoride (F) concentrations following intake of different doses of fluoride tablets were studied in six subjects. There was a close relationship between saliva F and plasma F and the ratio was 0.64 +/- 0.01 (s.e.). The plasma half life of F was 4-16 h. This results indicate that saliva F may be a useful substitute for blood sampling in studies concerning the pharmacokinetics of fluoride.
mesh_terms: D000284:Administration, Oral; D005459:Fluorides / Q000378:metabolism*; D006801:Humans; D008297:Male; D012463:Saliva / Q000032:analysis*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013607:Tablets
chemical_list: D013607:Tablets; D012969:Sodium Fluoride; D005459:Fluorides