title: Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture.
abstract: Nine osteosarcoma cell lines, originally developed from six osteosarcoma tumours in five patients, and two cell lines of non-tumour origin (glia and fibroblast) were grown in vitro in the presence of human leukocyte interferon (L-IF). L-IF exerted a dose-dependent inhibition of growth in all these lines. The inhibitory activity displayed characteristics typical of interferons. Inhibition of cell growth occurred at a much lower L-IF concentration for the osteosarcoma than for the non-tumour-derived lines. Inhibition of tumour cell growth was observed at concentrations obtained in the serum of osteosarcoma patients treated with interferon.
mesh_terms: D002452:Cell Count; D002460:Cell Line; D003470:Culture Media; D003851:Deoxyribonucleases / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007962:Leukocytes; D012516:Osteosarcoma / Q000276:immunology*; D012260:Ribonucleases / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
chemical_list: D003470:Culture Media; D007372:Interferons; D003851:Deoxyribonucleases; D012260:Ribonucleases; D014357:Trypsin