title: [Portal hypertension without liver cirrhosis in chronic vitamin A intoxication].
abstract: The ysmptoms and findings in a patient after prolonged intake of excessive amounts of vitamin A for treatment of psoriasis are presentd. All the characteristic signs of chronic intoxication were reversible after withdrawal of the medication. Initially portal hypertension could be demonstrated, although histologically there was no cirrhosis of the liver. During the period of observation the disturbed liver function returned to normal and the signs of portal hypertension disappeared completely. Reversibility of portal hypertension is a unusual observation and is discussed in relation to similar situations in toxic liver disease.
mesh_terms: D000328:Adult; D003680:Deglutition Disorders / Q000139:chemically induced; D003863:Depression / Q000139:chemically induced; D001068:Feeding and Eating Disorders / Q000139:chemically induced; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced*; D008297:Male; D011565:Psoriasis / Q000188:drug therapy; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014801:Vitamin A
vernacular_title: Portale Hypertonie ohne Leberzirrhose bei chronischer Vitamin-A-Intoxikation.