Collaborative evaluation of a rat caries model in six laboratories.
When highly controlled parallel rat caries studies were run simultaneously in six laboratories, a similar pattern of caries developed in every laboratory with a range in mean values such that the results of no investigator were significantly different from those of at least two others. These results indicate that the major factors influencing development of rat caries have been recognized and can be controlled within reasonable limits.
D000818:Animals; D003731:Dental Caries / Q000209:etiology*; D004037:Diet, Cariogenic; D004195:Disease Models, Animal; D005260:Female; D051381:Rats; D012107:Research Design; D013045:Species Specificity; D013290:Streptococcal Infections / Q000150:complications; D013295:Streptococcus mutans