title: Respective roles of short- and long-range interactions in protein folding.
abstract: A lattice model of protein is studied by a Monte Carlo simulation method. The native conformation of the lattice protein molecule is stabilized by specific long-range and short-ranged interactions. By comparing results of simulation for different relative weights of the long- and short-range interactions, it is concluded that the specific long-range interactions are essential for highly cooperative stabilization of the native conformation and that the short-range interactions accelerate the folding and unfolding transitions.
mesh_terms: D008956:Models, Chemical; D009010:Monte Carlo Method; D011487:Protein Conformation
references.citation: Biochem J. 1972 Jul;128(4):737-49
references.pmid: 4565129
references.citation: Int J Pept Protein Res. 1975;7(6):445-59
references.pmid: 1201909
references.citation: Biochemistry. 1968 Aug;7(8):2864-72
references.pmid: 5691142