Aminoglycoside antibiotics moderately impair granulocyte function.
By in vitro methods, five aminoglycoside antibiotics (amikacin, kanamycin, gentamicin, tobramycin, and netilmicin) were shown to produce modest changes in granulocyte adherence (increase) and migration (decrease) and no change in phagocytosis or nitroblue tetrazolium reduction.
D000583:Amikacin / Q000009:adverse effects; D000617:Aminoglycosides / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005839:Gentamicins / Q000009:adverse effects; D006098:Granulocytes / Q000187:drug effects*; D007612:Kanamycin / Q000009:adverse effects; D009428:Netilmicin / Q000009:adverse effects; D010587:Phagocytosis / Q000187:drug effects; D014031:Tobramycin / Q000009:adverse effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D007612:Kanamycin; D000583:Amikacin; D014031:Tobramycin
N Engl J Med. 1974 Sep 26;291(13):642-6
4852473
N Engl J Med. 1968 May 2;278(18):971-6
4384563
Antimicrob Agents Chemother. 1977 Apr;11(4):580-4
856009
Am J Pathol. 1968 Apr;52(4):725-36
4384494