title: Some recent progress in the analysis of malignancy by cell fusion.
abstract: Malignancy, as measured by the ability of cells to grow progressively in vivo, is intimately linked to the presence of a structural abnormality in the polysaccharide moiety of one particular membrane glycoprotein. This abnormality is present in a wide range of different tumours; it co-segregates with malignancy in all crosses between malignant and non-malignant cells that have so far been tested; and it remains linked to malignancy in a stringent new test in which non-malignant variants are selected from tumour cell populations by the use of a lectin. Current work indicates that the abnormal membrane glycoprotein is, in all probability, one of the glucose transport proteins.
mesh_terms: D000818:Animals; D001665:Binding Sites; D002459:Cell Fusion; D002478:Cells, Cultured; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D037102:Lectins; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype
chemical_list: D006023:Glycoproteins; D037102:Lectins; D008565:Membrane Proteins; D009363:Neoplasm Proteins