title: [Fetal hemoglobin in acute leukemias].
abstract: The question of fetal hemoglobin synthesis reactivation is a current topic both from the aspect of the genetic regulation of synthesis and from the aspect of the disorder of erythropoiesis in malignant diseases. The author presents the results of the quantitative determination of fetal hemoglobin in 84 children suffering from acute leukemias. The quantitation of HbF was performed by the method of alkalide-naturation and values of hemoglobin A2 by celulose-acetate electrophoresis. In acute lymphoblastic leukaemias fetal hemoglobin has been increased in 59% of the patients and in acute nonlymphoblastic leukaemias in 72% of the patients. The highest values of fetal hemoglobin were about 20%. The author considers that presence of fetal hemoglobin in these diseases cannot be a marker for estimation of remission and aggravation of the disease.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005319:Fetal Hemoglobin / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000097:blood; D007948:Leukemia, Monocytic, Acute / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood
chemical_list: D005319:Fetal Hemoglobin
vernacular_title: Fetalni hemoglobin u akutnim leukemijama.