title: Incidence of resistance to ampicillin, chloramphenicol, kanamycin and tetracycline among Salmonella species isolated in the Netherlands in 1972, 1973 and 1974.
abstract: The resistance of Salmonellae to drugs has been studied in the Netherlands since 1958. In 1972, 1973, and 1974 respectively, 14241, 13086, and 22927 strains were tested for resistance to ampicillin, chloramphenicol, kanamycin and tetracycline. From 1973 all strains were also tested for resistance to trimethoprim. In the period covered, the yearly incidence of resistance to at least one of the above drugs ranged from 39.2% to 45.6% of all strains obtained from various sources (humans, animals, animal products, sewage, etc.). A new finding in the period 1972 to 1974 was that many multiply resistant strains emerged in S. typhimurium and in S. dublin isolated from calves and cattle. In 1974, 64.4% of all strains of S. typhimurium from these animals appeared to be resistant to ampicillin, tetracycline, chloramphenicol and kanamycin, and 25.5% of those of S. dublin were found to be resistant to chloramphenicol and tetracycline. Of all strains of Salmonellae examined in 1973 and 1974 respectively, 0.15% and 0.22% were resistant to trimethoprim, the main component of the twin-drug cotrimoxazol. Of the 142 strains of S. typhi isolated in 1972 to 1974 two were resistant to tetracycline only, and one was resistant to all four antibiotics. The others had a normal susceptibility pattern.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology*; D009426:Netherlands; D010403:Penicillin Resistance; D012475:Salmonella / Q000187:drug effects*; D012480:Salmonella Infections / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000382:microbiology; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D007612:Kanamycin; D002701:Chloramphenicol; D000667:Ampicillin; D013752:Tetracycline
references.citation: Zentralbl Bakteriol Orig A. 1976 Jan;234(1):29-36
references.pmid: 943893
references.citation: Bull World Health Organ. 1971;45(1):85-93
references.pmid: 5316854
references.citation: J Bacteriol. 1976 Sep;127(3):1414-26
references.pmid: 783145
references.citation: Br Vet J. 1974 Mar-Apr;130(0):128-38
references.pmid: 4601304
references.citation: Zentralbl Bakteriol Orig A. 1974 Feb;226(2):201-6
references.pmid: 4151206
references.citation: Antimicrob Agents Chemother. 1974 Feb;5(2):161-8
references.pmid: 4840429
references.citation: Br Vet J. 1972 Apr;128(4):189-98
references.pmid: 4338221
references.citation: Zentralbl Bakteriol Orig A. 1976 Jan;234(1):37-45
references.pmid: 943894
references.citation: Biochem J. 1967 Oct;105(1):371-8
references.pmid: 4861886
references.citation: Zentralbl Bakteriol Orig A. 1973 Dec;225(2):257-62
references.pmid: 4150058
references.citation: Antonie Van Leeuwenhoek. 1967;33(1):30-40
references.pmid: 5340158
references.citation: Antonie Van Leeuwenhoek. 1973;39(2):321-9
references.pmid: 4541605