Lysozyme: a brief review.
Serum lysozyme (muramidase) estimation is a simple, convenient and useful laboratory investigation. A review of the literature shows that lysozyme has been implicated as an aetiological factor in various disorders, and credited with being a prognostic indicator in acute myeloid leukaemia, but these promises have not been fulfilled. This low molecular weight protein is found in the urine of some patients with renal tubular disorders, but some workers have emphasized its importance as a causal agent in hypokalaemia of acute myeloid leukaemia. Research should be concentrated on muramidase as an expression of cell functions rather than as an aetiological factor. Hypokalaemia in acute myeloid leukaemia may be caused by an unidentified substance of molecular weight similar to that of lysozyme.
D000818:Animals; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology; D015470:Leukemia, Myeloid, Acute / Q000209:etiology; D009113:Muramidase / Q000097:blood*; D011379:Prognosis
D009113:Muramidase
Proc Soc Exp Biol Med. 1949 Oct;72(1):220-2
15391720
N Engl J Med. 1967 Jul 6;277(1):10-2
6027292
Q J Med. 1963 Apr;32:165-192
14031597
J Clin Pathol. 1961 Mar;14:172-8
13689427
J Clin Invest. 1952 Jul;31(7):721-6
14938448
Ann Intern Med. 1975 Jan;82(1):54-7
16553
Cancer Res. 1974 Jan;34(1):47-60
4588549
Am J Med. 1969 Mar;46(3):330-43
4888852
Lancet. 1968 Feb 24;1(7539):371-5
4169970
Lancet. 1976 Apr 17;1(7964):835-7
56652
Lancet. 1975 Aug 2;2(7927):228-9
51982
Proc Soc Exp Biol Med. 1972 Nov;141(2):499-500
4508508
J Lab Clin Med. 1973 Jan;81(1):116-21
4508991
Aust N Z J Med. 1972 Feb;2(1):28-33
4502715
Br Med J. 1974 Sep 28;3(5934):775-7
4528597
Q J Med. 1973 Oct;42(168):677-82
4528596
Am J Med. 1975 Jan;58(1):57-64
1090151
J Clin Pathol. 1975 Sep;28(9):722-7
1058211
Clin Sci Mol Med. 1975 Mar;48(3):213-8
1054305
N Engl J Med. 1976 Feb 5;294(6):337
1246277
Ann Intern Med. 1975 Jun;82(6):855-6
1138614
Gastroenterology. 1975 Oct;69(4):893-6
1175883
N Engl J Med. 1975 Feb 20;292(8):424-5
1110730
N Engl J Med. 1975 Feb 20;292(8):395-7
1110725
J Clin Invest. 1970 Sep;49(9):1694-708
5270914
Am J Med. 1969 Sep;47(3):351-66
5258033
J Exp Med. 1966 Nov 1;124(5):921-52
5224561
N Engl J Med. 1964 Feb 6;270:269-74
14074651