Conversion of polycythemia vera to refractory anemia with hyperplastic bone marrow.
Clinical and morphologic findings in the conversion of treated polycythemia vera to pancytopenia with hyperplastic bone marrow (refractory anemia or pancytopenia with hyperplastic bone marrow) are described in light of our own observation. The nomenclature associated with this condition (pancytopenia, chronic erythroleukemia, preleukemia) is not uniform, whereas the morphologic findings are virtually identical. Some patients subsequently develop acute leukemia. The prognosis in cases of refractory anemia with hyperplastic bone marrow following polycythemia vera is, independent of the subsequent acute leukemia, invariably terminal.
D000741:Anemia, Aplastic / Q000209:etiology*; D002908:Chronic Disease; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications* / Q000401:mortality; D015470:Leukemia, Myeloid, Acute / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications; D011087:Polycythemia Vera / Q000150:complications*; D011289:Preleukemia / Q000209:etiology; D011379:Prognosis; D013577:Syndrome; D009626:Terminology as Topic
N Engl J Med. 1976 Oct 21;295(17):913-6
967201
Blood. 1976 Feb;47(2):237-41
1244921
Cancer. 1971 Aug;28(2):513-8
5566368
Am J Med. 1964 Aug;37:162-71
14206750
Arch Intern Med. 1974 Jul;134(1):113-7
4833938
JAMA. 1968 Jun 17;204(12):1141-3
5240470
Med Klin. 1976 Nov 26;71(48):2127-35
1004362
Ann Intern Med. 1975 Nov;83(5):672-3
1060392
JAMA. 1973 Jan 8;223(2):192
4510937
N Engl J Med. 1966 Sep 1;275(9):489-90
5223152
Cancer. 1976 Dec;38(6):2242-6
1069602
Semin Hematol. 1976 Jan;13(1):33-48
766188