[Animal experimental studies on the prevention of cleft palate and other malformations in the region of the head].
In fetuses of eight-week old female Swiss mice, teratogenic effects were produced by cyclophosphamid on different days of pregnancy. Frequently and combinations of malformation of a positive control group (30 mg/kg b.w. on the 11.5th day of pregnancy) were compared with "prophylaxis" groups. Pyrithioxin (Encephabol) significantly reduces the number of some malformations. The goal, i.e. to obtain normal fetuses without malformations, was not achieved, however. The best effect was obtained with 1/160 LD50 of Encephabol administered in four doses prior to Endoxan.
D000015:Abnormalities, Multiple / Q000517:prevention & control*; D000818:Animals; D002972:Cleft Palate / Q000517:prevention & control*; D003520:Cyclophosphamide; D007928:Lethal Dose 50; D051379:Mice; D011746:Pyrithioxin / Q000627:therapeutic use
D003520:Cyclophosphamide; D011746:Pyrithioxin
Tierexperimentelle Untersuchungen zur Prophylaxe von Gaumenspalten und anderen Missbildungen im Kopfbereich