title: Malignant transformation of ameloblastic fibro-odontoma to ameloblastic fibrosarcoma.
abstract: Two cases of malignant transformation of ameloblastic fibro-odontomas are presented, along with a review of the literature on ameloblastic fibrosarcomas. The occurrence of this malignant transformation of ameloblastic fibromas, ameloblastic odontomas, and ameloblastic fibro-odontomas appears to be more frequent than previously thought. This potential transformation alone does not justify radical treatment of all these benign lesions. If there is recurrence accompanied by a histologic pattern change toward a more unorganized fibrous stroma with displacement of the epithelial component, however, then more extensive treatment procedures appear to be indicated.
mesh_terms: D000293:Adolescent; D000328:Adult; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors / Q000473:pathology*