title: Lidocaine's influence on the accumulation and depletion rates of mouse brain amines.
abstract: Mouse brain was analyzed for serotonin, norepinephrine, and dopamine. Pargyline plus lidocaine treatment caused an increased accumulation rate of serotonin over one hour compared to pargyline controls. alpha Methyl-p-tyrosine plus lidocaine treatment caused a decreased depletion rate of dopamine over four hours compared to rates of alpha methyl-p-tyrosine controls, and no difference for norepinephrine.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D012701:Serotonin / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D018492:Dopamine Antagonists; D008781:Methyltyrosines; D012701:Serotonin; D008012:Lidocaine; D010293:Pargyline; D004298:Dopamine; D009638:Norepinephrine