Bronchiectasis in acute leukaemia.
Five children in remission from acute lymphoblastic leukaemia developed bronchiectasis when on chemotherapy. Persistent collapse or consolidation on chest radiographs was helpful in suggesting the diagnosis. Necropsy established the diagnosis in one child who died of massive haemoptysis when in complete remission, and bronchography confirmed the diagnosis in three. In a further child the diagnosis was based on clinical and chest X-ray findings alone. The surviving children were treated with prophylactic rotating antibiotics. Routine chest radiographs are recommended in children with acute lymphoblastic leukaemia, as bronchiectasis may otherwise be underdiagnosed.
D001987:Bronchiectasis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D012075:Remission, Spontaneous; D012141:Respiratory Tract Infections / Q000150:complications*
Cancer Res. 1971 Apr;31(4):420-6
4994993
J Pediatr. 1974 Feb;84(2):183-92
4810725
Br Med J. 1973 May 19;2(5863):385-8
4574043
Blood. 1972 Jun;39(6):759-70
4337622
Br Med J. 1975 May 31;2(5969):467-70
1148660
Arch Dis Child. 1969 Oct;44(237):551-61
5345322
Arch Dermatol. 1971 Mar;103(3):250-61
5548272