Trajectories of human granulocytes.
The spatial trajectories of human granulocytes moving on glass in two dimensions under an isotropic medium may be characterized as realizations of a correlated walk. The present model is similar to an earlier one for slime-mold amebae. The correlation from step to step is essentially via the relative angle theta, represented for granulocytes as a random variable with a symmetric bimodal density. As the cells age, they appear to turn less and the degree of correlation increases. Even under chemotaxis the angle theta and the step length r appear to be statistically independent.
D002465:Cell Movement; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008954:Models, Biological
J Pathol Bacteriol. 1953 Jul;66(1):135-46
13109626
J Math Biol. 1977 Oct 20;4(4):327-35
562913
Exp Cell Res. 1978 Jan;111(1):191-203
340239
J Cell Biol. 1978 May;77(2):269-87
649652
Biophys J. 1976 Oct;16(10):1171-82
963197
J Theor Biol. 1974 Sep;47(1):103-11
4617811
Exp Cell Res. 1972 Nov;75(1):288-90
4635887
Biophys J. 1972 Aug;12(8):1048-55
5044578
J Theor Biol. 1975 Apr;50(2):477-96
1094203
Biophys J. 1976 Mar;16(3):249-59
1252580
Biophys J. 1970 Oct;10(10):980-93
5531614