Basophilic differentiation of chronic myelogenous leukaemia cells in vitro.
Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed in increased proportion of mature basophilis at about 3 weeks and most cultures consisted  predominantly of mature basophilis at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.
D000328:Adult; D001491:Basophils / Q000473:pathology / Q000648:ultrastructure; D002454:Cell Differentiation; D002478:Cells, Cultured; D002877:Chromosomes, Human; D003470:Culture Media; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000235:genetics; D007958:Leukocyte Count; D007962:Leukocytes / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D003470:Culture Media