Specificity of cholecystokinin satiety effect: reduction of food but not water intake.
The C-terminal octapeptide of cholecystokinin (CCK) was injected into water-deprived rats to observe the effect on water and milk intake. The doses used were 0, 20, and 40 Ivy dog units/kg. The data indicated that milk intake was suppressed in a dose-related fashion within 2-4 min of injection but water intake was not suppressed. This satiety hormone is thus specific to food intake.
D000704:Analysis of Variance; D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology
D002766:Cholecystokinin; D012844:Sincalide