[Degenerative retinal conditions after treatment with Busulfan during pregnancy (author's transl)].
A patient with chronic granulocytic leukemia was treated with Busulfan for the three last months of pregnancy. The infant appeared normal except for an atypical tapetoretinal degeneration. We studied the other cases in the literature. All pregnancies produced an apparently normal infant although three infants were small. The case of Diamond had microphthalmia. We conclude that Busulfan is perhaps toxic to fetal retina.
D000328:Adult; D002066:Busulfan / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D012162:Retinal Degeneration / Q000139:chemically induced* / Q000151:congenital
D002066:Busulfan
Degenerative Netzhauterkrankungen nach Behandlung der Mutter mit Busulfan während der Schwangerschaft.