Insulin and growth hormone secretion in a leukaemic girl with hypothalamic syndrome.
The authors report a girl with acute lymphoblastic leukaemia presenting hypothalamic syndrome characterized by meningeal leukaemia, hyperphagia and obesity. Insulin and growth hormone secretion, studied with arginine and insulin stimulation tests, showed a high peak of serum insulin and no response of growth hormone. Insulin and growth hormone responses to these tests reverted to normal after intrathecal methotrexate.
D001120:Arginine; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007945:Leukemia, Lymphoid / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008727:Methotrexate / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy / Q000209:etiology; D014221:Triamcinolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D007328:Insulin; D014221:Triamcinolone; D014750:Vincristine; D013006:Growth Hormone; D001120:Arginine; D008727:Methotrexate