Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.
The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D002417:Cattle; D002918:Chymotrypsin; D010446:Peptide Fragments / Q000032:analysis; D013820:Thermolysin; D013947:Thymosin / Q000276:immunology / Q000302:isolation & purification; D013950:Thymus Gland; D013951:Thymus Hormones / Q000276:immunology; D014357:Trypsin
D000596:Amino Acids; D010446:Peptide Fragments; D013951:Thymus Hormones; D013947:Thymosin; D002918:Chymotrypsin; D014357:Trypsin; D013820:Thermolysin
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