Morphometry of the renal corpuscle during normal postnatal growth and compensatory hypertrophy. A light microscope study.
Renal corpuscles from the juxtamedullary and subcapsular regions of the renal cortex were morphometrically analyzed in young rats and in adult rats that had been unilaterally nephrectomized or sham-operated at an early age. Mean corpuscular volumes increased 4.5-fold during normal development, and 7.7-fold as a result of compensatory hypertrophy in both cortical regions. Relative and absolute volumes were determined for Bowman's space, the glomerular tuft, and five glomerular components: epithelial, endothelial, and mesangial cells, capillaries, and the filtration membrane. Normal and hypertrophic enlargement of Bowman's space was slightly greater than glomerular growth, and the growth response of subcapsular glomeruli was greater than that of juxtamedullary glomeruli. The ratio of mean glomerular volumes between outer and inner glomeruli was 1:2 in both adult groups. Both adult groups also developed nearly identical proportions of all glomerular component structures, representing a relative decrease of epithelial cells and increase of capillaries compared to the young animals. Normal and hypertrophic maturation involved absolute increases in all glomerular cell populations, the length of capillary loops and the surface area of the filtration membrane, all nearly in proportion to the respective four- and seven-fold increases in glomerular volume. Changes in the filtration surface area are consistent with published data for glomerular filtration rates in normal and hypertrophied kidneys. The mean cell size in epithelial and mesangial populations doubled during growth, but was not greater than normal in mononephrectomized rats. Hyperplasia among all populations of glomerular cells is indicated in normal growth, and to a greater extent in compensatory renal hypertrophy.
D000375:Aging; D000818:Animals; D006984:Hypertrophy; D007672:Kidney Cortex / Q000166:cytology / Q000254:growth & development* / Q000473:pathology; D007678:Kidney Glomerulus / Q000166:cytology / Q000254:growth & development; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
Lab Invest. 1971 Jun;24(6):499-503
5090999
Yale J Biol Med. 1970 Dec;43(3):164-72
5499193
J Clin Invest. 1971 Apr;50(4):779-95
5547275
J Cell Biol. 1968 Apr;37(1):27-46
5645844
Lab Invest. 1968 Jun;18(6):700-8
5667867
Microvasc Res. 1973 Nov;6(3):273-85
4149031
Am J Med. 1973 Mar;54(3):281-9
4571744
Am J Physiol. 1972 Nov;223(5):1184-90
4654351
J Physiol. 1973 Jan;228(1):193-202
4686024
Am J Physiol. 1973 Nov;225(5):1247-51
4745228
J Clin Invest. 1973 Nov;52(11):2885-95
4748514
J Clin Invest. 1974 Jan;53(1):279-87
4808641
Kidney Int. 1974 Feb;5(2):122-30
4815218
Kidney Int. 1974 Feb;5(2):131-6
4815219
Lab Invest. 1974 May;30(5):657-63
4825823
Pflugers Arch. 1974;346(4):279-90
4856390
Lab Invest. 1969 Sep;21(3):269-75
4897638
Int Rev Cytol. 1969;26:235-302
4899604
Lab Invest. 1968 Dec;19(6):573-9
5707113
Am J Pathol. 1966 Jul;49(1):1-13
5944761
Nephron. 1966;3(6):352-65
5958781
Am J Pathol. 1967 Jan;50(1):1-14
6017684
Z Wiss Mikrosk. 1961 Dec;65:70-82
13889833
Am J Pathol. 1927 Jul;3(4):329-342.1
19969751