Juxtacortical (parosteal) osteogenic sarcoma: histological grading and prognosis.
In twenty-four cases of juxtacortical osteogenic sarcoma, three histological grades of malignancy were identified and correlated with the prognosis. The eighteen patients with Grade-I or II tumors had a significantly better prognosis than the six with Grade-III lesions. The three grades could not be distinguished roentgenographically. Grade I and II tumors, which showed a high cure rate after amputation, may be amenable to en block resection, provided the entire tumor can be removed with a good margin of uninvolved soft tissue and underlying bone. Grade-III tumors, on the other hand, had a poor prognosis despite early radical surgery.
D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D001706:Biopsy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology; D005269:Femur / Q000473:pathology; D006801:Humans; D006811:Humerus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology*; D011379:Prognosis; D011859:Radiography; D013639:Tarsal Bones / Q000473:pathology; D013977:Tibia / Q000473:pathology