Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile.
beta-Aminopropionitrile, a specific inhibitor of lysyl oxidase prevented the rise in blood pressure induced by deoxycorticosterone-salt in rats. In addition, after the onset of hypertension, administration of beta-aminopropionitrile lowered the blood pressure. Concomitant with the lowering of blood pressure, there was a reduction in the more highly crosslinked form of vascular collagen. These findings would indicate that increases in vascular connective tissue are not only sequelae of hypertension, but may also contribute to the maintenance of elevated blood pressure.
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors; D000629:Aminopropionitrile / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D003094:Collagen / Q000378:metabolism*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D008239:Lysine; D008297:Male; D051381:Rats; D012995:Solubility
D000629:Aminopropionitrile; D003900:Desoxycorticosterone; D003094:Collagen; D000594:Amino Acid Oxidoreductases; D008239:Lysine
J Clin Invest. 1939 May;18(3):373-6
16694670
Circ Res. 1967 Jan;20(1):136-45
6018220
Ann N Y Acad Sci. 1963 Jul 8;107:935-44
13947412
Science. 1954 Aug 20;120(3112):307-8
13186839
Am J Pathol. 1952 Nov-Dec;28(6):1059-77
12985834
Biochem Pharmacol. 1974 Aug;23(15):2165-73
4369964
Biochemistry. 1967 Apr;6(4):1142-8
6067864
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3019-23
4370097
Science. 1975 Nov 28;190(4217):898-900
171771
Proc Natl Acad Sci U S A. 1968 Oct;61(2):708-16
5246001
Proc Natl Acad Sci U S A. 1966 Feb;55(2):417-24
5220959
Biochemistry. 1970 Nov 10;9(23):4486-92
5474144
Anal Biochem. 1967 May;19(2):249-55
6048697
Biochem Biophys Res Commun. 1967 Jan 23;26(2):132-7
6030261
J Exp Med. 1959 Nov 1;110:771-90
14416144