Cytogenetic effects of chemotherapy and cranial irradiation on the peripheral blood lymphocytes of children with malignant disease.
Results of a cytogenetic analysis of peripheral blood lymphocytes of children with leukemia after massive chemotherapy and cranial irradiation, and of children with nephrosis after coritisone therapy and cyclophosphamide are presented. Prolonged intensive chemotherapy results in a significant rise in the number of chromatid aberrations after twelve months, and of chromosomal aberrations after 24 months of therapy. After cranial irradiation a sharp rise in chromosome aberrations is present for about three months. This drops after one year to levels present in cases with chemotherapy alone.
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000532:radiotherapy; D002648:Child; D002869:Chromosome Aberrations; D003348:Cortisone / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000628:therapy*; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D009401:Nephrosis / Q000188:drug therapy / Q000235:genetics; D013997:Time Factors
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D003348:Cortisone