title: Microspectrophotometric determination of DNA in oral lesions.
abstract: The DNA content of the epithelial basal cells of oral lesions was determined by Feulgen microspectrophotometry. The DNA histograms of the radicular cysts showed a definite peak in the diploid range and a slight deviation to the right. The keratocysts also showed a well-defined modal peak in the diploid range; however, another cell population defined a peak in the tetraploid range. In leukoplakias of the oral cavity, two different profiles of DNA distribution were found. Where both the clinical and microscopic traits defined a nondysplastic lesion, the histogram showed a diploid peak and a percentage of cells in diploid-tetraploid range. For the more active lesion, a shift of the mode towards higher values was evident. The microspectrophotometric studies of oral epidermoid carcinomas showed a broad distribution towards the right and ill-defined modal values.
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007972:Leukoplakia, Oral / Q000032:analysis; D009062:Mouth Neoplasms / Q000032:analysis*; D009807:Odontogenic Cysts / Q000032:analysis; D011003:Ploidies; D011230:Precancerous Conditions / Q000032:analysis*; D011842:Radicular Cyst / Q000032:analysis; D013053:Spectrophotometry / Q000379:methods
chemical_list: D004273:DNA, Neoplasm