Lymphocyte mitogenesis induced by a mammalian liver protein that specifically binds desialylated glycoproteins.
A purified rabbit liver membrane protein that binds desialylated glycoproteins has been shown to be a mitogen for human peripheral lymphocytes. The mitogenic activity is specific for desialylated thymus-derived (T)-cells. The loss of mitogenicity upon exposure of the binding protein to neuraminidase and the inhibitory potency of asialo-orosomucoid support the conclusion that the site involved in the binding of asialoglycoproteins is also responsible for the mitogenic effect on desialylated lymphocytes. The potential relevance of this phenomenon to the etiology of hepatocellular necrosis is considered.
D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects; D003208:Concanavalin A; D004261:DNA Replication / Q000187:drug effects; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008565:Membrane Proteins / Q000494:pharmacology*; D009439:Neuraminidase; D011817:Rabbits; D012794:Sialic Acids
D002352:Carrier Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D012794:Sialic Acids; D003208:Concanavalin A; D009439:Neuraminidase
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