Acute leukemia after chemotherapy (melphalan).
During the years 1966-1973 474 patients with ovarian carcinoma were treated with melphalan. Of these, 48 patients received at least 300 mg melphalan and survived at least 3 years; four cases of acute leukemia were found among these 48 patients. All cases belonged to a group of 12 cases receiving 800 mg melphalan or more.
D000208:Acute Disease; D000368:Aged; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced*; D004915:Leukemia, Erythroblastic, Acute / Q000139:chemically induced; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced; D008558:Melphalan / Q000009:adverse effects*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013997:Time Factors
D008558:Melphalan