title: Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice.
abstract: Inoculation of newborn mice with lymphocytic chloriomeningitis (LCM) virus resulted in decreased weight gain, liver cell necrosis, and death. Injection of potent sheep immunoglobulin against mouse interferon markedly inhibited these manifestations of LCM virus disease despite the fact that these treated mice had 100-fold more LCM virus in their serum. We conclude that interferon induced by LCM virus is responsible in large part for the syndrome of growth inhibition, liver cell necrosis, and death observed in LCM virus-infected suckling mice.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D000906:Antibodies; D001769:Blood / Q000382:microbiology; D006128:Growth; D007167:Immunotherapy; D007372:Interferons / Q000097:blood / Q000276:immunology; D008099:Liver / Q000473:pathology; D008216:Lymphocytic Choriomeningitis / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D008217:Lymphocytic choriomeningitis virus / Q000302:isolation & purification; D051379:Mice
chemical_list: D000906:Antibodies; D007372:Interferons
references.citation: Arch Gesamte Virusforsch. 1963 Oct 7;14:55-64
references.pmid: 14093843
references.citation: Cold Spring Harb Symp Quant Biol. 1962;27:479-99
references.pmid: 13955006
references.citation: Can J Microbiol. 1958 Apr;4(2):149-63
references.pmid: 13523457
references.citation: J Exp Med. 1976 Nov 2;144(5):1316-23
references.pmid: 186555
references.citation: J Exp Med. 1976 Nov 2;144(5):1305-15
references.pmid: 186554
references.citation: Nature. 1976 Sep 30;263(5576):420-2
references.pmid: 972680
references.citation: J Virol. 1971 Jun;7(6):792-801
references.pmid: 4327587
references.citation: J Gen Virol. 1975 Jun;27(3):395-8
references.pmid: 167120
references.citation: J Immunol. 1974 Aug;113(2):438-44
references.pmid: 4602660
references.citation: Nature. 1973 Nov 9;246(5428):92-4
references.pmid: 4585853
references.citation: J Gen Virol. 1971 Oct;13(1):163-5
references.pmid: 4331809
references.citation: Proc Soc Exp Biol Med. 1972 Dec;141(3):769-73
references.pmid: 4566752
references.citation: Nat New Biol. 1972 May 24;237(73):120-1
references.pmid: 4503851
references.citation: Nat New Biol. 1973 Apr 4;242(118):152-3
references.pmid: 4573479
references.citation: Proc Soc Exp Biol Med. 1969 Jan;130(1):236-42
references.pmid: 4302959
references.citation: Proc Natl Acad Sci U S A. 1970 Aug;66(4):1052-8
references.pmid: 4319881
references.citation: J Immunol. 1975 Jan;114(1 Pt 2):403-9
references.pmid: 1090660
references.citation: Proc Natl Acad Sci U S A. 1975 May;72(5):1753-7
references.pmid: 168573
references.citation: J Immunol. 1976 Sep;117(3):748-53
references.pmid: 182881
references.citation: C R Acad Sci Hebd Seances Acad Sci D. 1973 Nov 12;277(19):2101-3
references.pmid: 4208698
references.citation: J Immunol. 1974 Oct;113(4):1319-25
references.pmid: 4607133
references.citation: Adv Cancer Res. 1972;16:97-140
references.pmid: 4628253
references.citation: Transplantation. 1974 Feb;17(2):234-6
references.pmid: 4590293
references.citation: Ann Microbiol (Paris). 1973 Oct;124(3):363-70
references.pmid: 4599375
references.citation: Proc Natl Acad Sci U S A. 1973 Oct;70(10):2785-8
references.pmid: 4517933
references.citation: Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5
references.pmid: 4501586
references.citation: Arch Gesamte Virusforsch. 1970;30(1):67-74
references.pmid: 4986679
references.citation: Nature. 1976 Jul 22;262(5566):300-2
references.pmid: 958376
references.citation: Nature. 1975 Nov 6;258(5530):76-8
references.pmid: 1186883
references.citation: Science. 1975 Nov 7;190(4214):574-6
references.pmid: 1188355