Insulin-induced liver hyperplasia: evidence for a negative liver-size-correcting process.
The fate of the increased liver DNA induced by insulin treatment of rats with chronic steptozotocin-induced diabetes was studied. The DNA content of the organ was restored to normal by an active process having a half-time of 32 days. The half-time of disappearance of thymidine-labelled DNA in the same livers was 81 days. The results indicate the existence of a mechnanism which acts to restore normal liver cellularity when an over-production of cells has occurred.
D000818:Animals; D001835:Body Weight; D002452:Cell Count; D004247:DNA / Q000032:analysis / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D006207:Half-Life; D006529:Hepatomegaly / Q000473:pathology*; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size; D051381:Rats
D007328:Insulin; D004247:DNA