Tumor-associated humoral cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy.
Sera of eight unselected adult patients with acute myelogenous leukemia obtained before and after chemotherapy were repeatedly tested for specific complement-dependent cytotoxicity against autochthonous peripheral white blood cells from the acute leukemia stage and from the remission stage, respectively. Complement-dependent cytotas demonstrated in all of the eight patients, while none of three patients' sera were reactive against white blood cells from the remission stage tested in parallel. The cytotoxicity was increased after chemotherapy, also in those patients in whom remission was not achieved.
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D007136:Immunoglobulins; D003165:Complement System Proteins