Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose.
A new fatty liver model is described in which heredity plays a major role. A marked fatty liver develops when the homozygous mutant Zucker rat (ff or "fatty") is fed a semi-synthetic diet enriched in sucrose. Lean littermates do not develop fatty livers on this experimental diet. Even old ff rats do not develop fatty livers on chow; the experimental diet is required. The fatty liver is described, including light microscopic and preliminary electron microscopic observations.
D000818:Animals; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*; D005260:Female; D006720:Homozygote; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013347:Subcellular Fractions / Q000648:ultrastructure; D013395:Sucrose
D013395:Sucrose
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