Metabolic studies of iron-poly (sorbitol-gluconic acid) complex, Ferastral.
The metabolism of iron-poly (sorbitol-gluconic acid) complex (Ferastral) was studied in 6 blood donors with latent iron deficiency and 13 patients with manifest iron deficiency anaemia. Between 125 and 1 000 mg of iron were injected. In latent deficiency an average of 19% of the dose given was excreted during the first two weeks. The corresponding figure for patients with manifest iron deficiency was 11%. An average of 8% of the dose was retained at the site of injection after 40 days. In the two groups, respectively, 61% (range 47%-70%) and 58% (range 24%-86%) of the iron retained was incorporated into red cells after 40 days, which is judged to be quite satisfactory. Some local side effects were observed.
D000328:Adult; D000368:Aged; D000747:Anemia, Hypochromic / Q000188:drug therapy* / Q000378:metabolism; D004338:Drug Combinations; D004341:Drug Evaluation; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005942:Gluconates / Q000378:metabolism; D006801:Humans; D007273:Injections, Intramuscular; D007501:Iron / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D013012:Sorbitol / Q000378:metabolism
D004338:Drug Combinations; D005942:Gluconates; D013012:Sorbitol; D007501:Iron