A powerful inhibitor of guanine deaminase.
The synthesis of 9-(p-carbetoxyphenyl) guanine is reported. The assays carried out on guanine deaminase from rat and rabbit liver and pig brain show that this compound is a powerful inhibitor. The compound has a Ki = 5 micronM for the enzyme from pig brain. The use of the inhibitor for the synthesis of a specific adsorbent for guanine deaminase was studied.
D000619:Aminohydrolases / Q000037:antagonists & inhibitors*; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000201:enzymology; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006148:Guanine Deaminase / Q000037:antagonists & inhibitors*; D008024:Ligands; D008099:Liver / Q000201:enzymology; D011485:Protein Binding; D051381:Rats; D012685:Sepharose; D013552:Swine
D008024:Ligands; D006147:Guanine; D012685:Sepharose; D000619:Aminohydrolases; D006148:Guanine Deaminase