title: [Modification of the strain Flury HEP after its adaptation to cell culture. Development of experimental vaccine for veterinary use].
abstract: The rabies strain Flury HEP, adapted in our laboratory to BHK21 cells, shows, after 20 passages on this cell, an important modification of its pathogenic characteristics on adult mice, guinea pigs and hamsters. An experimental vaccine made with this adapted strain gives a good sero-conversion rate when injected by the intramuscular route to a group of dogs.
mesh_terms: D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004285:Dogs; D006168:Guinea Pigs; D007668:Kidney; D051379:Mice; D011818:Rabies / Q000382:microbiology*; D011819:Rabies Vaccines; D011820:Rabies virus / Q000254:growth & development* / Q000472:pathogenicity; D013045:Species Specificity
chemical_list: D011819:Rabies Vaccines
vernacular_title: Modifications de la souche Flury HEP a la suite de son adaptation a la culture cellulaire. Réalisation d'un vaccin expérimental a usage vétérinaire.