Effect of GABA-transminase inhibition on rectal temperature in mice.
gamma-Acetylenic GABA (amino-4-hex-5-ynoic acid) and gamma-vinyl GABA (amino-4-hex-5-enoic acid), two catalytic irreversible inhibitors of GABA-transaminase, produce marked sustained elevations in brain GABA concentrations. Associated with these biochemical changes is a decrease in the rectal temperature of mice. This hypothermia can be reversed by increasing ambient temperature. The results suggest GABA plays an important role in mammalian central thermoregulation.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000480:Alkynes; D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D012007:Rectum; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000480:Alkynes; D000614:Aminocaproates; D005680:gamma-Aminobutyric Acid; C013785:4-amino-5-hexynoic acid; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin