How to label nerve cells so that they can interconnect in an ordered fashion.
We present a method for setting up topographically ordered mappings between two sheets of nerve cells. A set of chemical markers that express the neighborhood relationships within the presynaptic sheet is induced by the fibers into the postsynaptic sheet. The markers are used to guide the fibers to their terminal sites. A case for which this idea may be relevant is the retinotectal projection; our model exhibits types of plasticity found experimentally. The fact that the postsynaptic markers remain after removal of the projecting fibers suggests an important difference between development and regeneration. This paper concentrates on explaining the basic idea, and in addition presents a set of preliminary computer simulations.
D002452:Cell Count; D008954:Models, Biological; D009434:Neural Pathways / Q000254:growth & development*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology
J Physiol. 1963 Mar;165:484-99
13946933
Proc R Soc Lond B Biol Sci. 1976 Nov 12;194(1117):447-66
12511
Proc R Soc Lond B Biol Sci. 1976 Nov 12;194(1117):431-45
12510
J Cell Sci. 1974 Jul;15(2):321-46
4859215
Proc R Soc Lond B Biol Sci. 1974 Feb 12;185(1080):301-30
4149927
Proc R Soc Lond B Biol Sci. 1975 Jun 20;190(1098):77-98
237289
Nature. 1972 Jun 16;237(5355):375-8
4557322
Dev Biol. 1974 Sep;40(1):1-15
4412787
Exp Neurol. 1974 Jun;43(3):527-38
4827162
Brain Behav Evol. 1973;8(1):73-109
4777719
Science. 1973 May 4;180(4085):509-11
4700606
Brain Res. 1975 May 2;88(2):339-45
1080068
Arch Ital Biol. 1971 Dec;109(4):357-66
5151235
Exp Neurol. 1971 Nov;33(2):395-411
5124957