The influence of parathyroidectomy upon calcium and phosphate homeostasis in adult sheep.
The absorption and secretion of Ca and PO4 were measured with the use of radioactive isotopes in 4 adult sheep before and after parathyroidectomy. Secretion of Ca and PO4 into the stomach and intestines was measured separately. Parathyroidectomy resulted in a negative balance for Ca and PO4 and an accompanying fall in plasma Ca and PO4 concentrations. In the case of PO4 this response was attributed primarily to a reduced intestinal absorption, but for Ca increases in urinary excretion and intestinal secretion also contributed significantly. Secretion of PO4 to the stomach was reduced but endogenous PO4 excretion in the faeces was unchanged which indicated a reduced reabsorption of secreted PO4 by the intestines.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006706:Homeostasis; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D010280:Parathyroid Glands / Q000502:physiology* / Q000601:surgery; D010710:Phosphates / Q000378:metabolism*; D012756:Sheep / Q000502:physiology*
D010710:Phosphates; D002118:Calcium