The investigation of a recurrence of an AHC virus epidemic at Lucknow: a serosurvey for AHC virus antibodies before and after the epidemic.
An epidemic of acute haemorrhagic conjunctivitis (AHC) recurred at Lucknow during July to September 1975, after a gap of 4 years. Out of the 35 cases investigated thoroughly, 20 Entero-70-like cytopathogenic agents were isolated from the conjunctiva which were neutralized by antisera against AHC virus J670/71 of Japan. Seroconversion was seen in 7 out of 11 paired sera from patients. Serological study was also done on 100 sera collected before the AHC epidemic of 1971, 100 sera after 1971 and 100 sera after 1975 epidemic. There were no neutralizing antibodies in the pre-epidemic period, while 18% of sera after the first epidemic and 32% after the second epidemic showed antibodies. The incidence of antibodies was highest (43%) in children aged below 10 years. Of the children born after the first epidemic, 44% had antibodies. Thus our findings show that the AHC virus appeared for the firt time at Lucknow in 1971 and the almost complete absence of disease in children, and its mildness during second epidemic, may be due to immunity.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D003231:Conjunctivitis / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D004196:Disease Outbreaks / Q000453:epidemiology*; D004769:Enterovirus Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009500:Neutralization Tests; D012008:Recurrence
D000914:Antibodies, Viral
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165719
Br J Ophthalmol. 1975 Aug;59(8):439-43
173388
Am J Epidemiol. 1975 May;101(5):383-90
1130401
Am J Epidemiol. 1975 Dec;102(6):533-44
1202955
Lancet. 1972 Jun 3;1(7762):1191-4
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Lancet. 1972 Nov 4;2(7784):970-1
4116842
Lancet. 1973 Feb 17;1(7799):350-2
4121939
Southeast Asian J Trop Med Public Health. 1973 Mar;4(1):11-4
4198002
Bull World Health Organ. 1973;49(4):341-6
4368683
Singapore Med J. 1973 Jun;14(2):86-9
4741439
Br J Ophthalmol. 1972 Jun;56(6):501-3
5069192
Practitioner. 1971 Dec;207(242):805-6
5143904