title: Prognostic significance of radiological bone involvement in childhood acute lymphoblastic leukaemia.
abstract: In 98 children with acute lymphoblastic leukaemia, aged 1 to 12 years, the prognostic significance of radiological bone involvement was studied. The mean duration of remission and of survival was much shorter in cases with multiple bone involvement (3 or more bones) than in those where bone involvement was absent. In those cases presenting with 1 or 2 bone lesions no statement of prognostic significance can be made at this stage. A radiological skeletal survey should be made in all children presenting with leukaemia to identify those (about 15%) having multiple bone lesions and therefore a poor prognosis, in order that they can be given more intensive therapy.
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000000981:diagnostic imaging / Q000401:mortality; D008297:Male; D009362:Neoplasm Metastasis; D011379:Prognosis; D011859:Radiography; D012075:Remission, Spontaneous
references.citation: Ann Intern Med. 1965 Apr;62:698-705
references.pmid: 14274834
references.citation: Blood. 1964 Apr;23:526-44
references.pmid: 14138243
references.citation: Indian Pediatr. 1975 May;12(5):430-3
references.pmid: 1057530
references.citation: Am J Dis Child. 1972 Nov;124(5):653-4
references.pmid: 4508099
references.citation: J Pediatr. 1975 Oct;87(4):672-6
references.pmid: 1057644
references.citation: Psychol Bull. 1959 Jan;56(1):26-47
references.pmid: 13623958