Elastic model of supercoiling.
An elastic model for the supercoiling of duplex DNA is developed. The simplest assumptions regarding the elastic properties of double-helical DNA (homogeneous, isotropic, of circular cross section, and remaining straight when unstressed) will generate two orders of superhelicity when stressed. Recent experimental results [Brady, G.W., Fein, D.B. & Brumberger, H. (1976) Nature 264, 231-234] suggest that in supercoiled DNA molecules there are regions where two distinct orders of supercoiling arise, as predicted by this model.
D004247:DNA; D004548:Elasticity; D008433:Mathematics; D009690:Nucleic Acid Conformation
D004247:DNA
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3068-72
1067602
Nature. 1976 Nov 18;264(5583):231-4
1004545
Nat New Biol. 1971 May 5;231(18):5-8
5282853
J Mol Biol. 1968 Apr 14;33(1):141-71
4296517
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4280-4
1060106
J Mol Biol. 1968 Jul 14;35(1):111-29
5760559
J Mol Biol. 1973 Sep 25;79(3):451-70
4758062
J Mol Biol. 1969 Jul 14;43(1):25-39
4897794
Proc Natl Acad Sci U S A. 1971 Apr;68(4):815-9
5279522
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2639-43
1066673
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4275-9
172901