Aplasia and leukaemia following chloroquine therapy.
Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed three weeks after ingestion of the drug. The mechanism(s) of chloroquine-induced marrow injury is not known. A parallel to chloramphenicol-induced blood dyscrasias is drawn, but remains unproved.
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D001853:Bone Marrow / Q000473:pathology; D002738:Chloroquine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008288:Malaria / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D002738:Chloroquine
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