5'-deoxypyridoxal as a potential anti-sickling agent.
5'-Deoxypyridoxal, which reacts specifically with the terminal amino groups of the alpha chains of hemoglobin, increases the oxygen affinity of hemoglobin solutions as well as of dilute suspensions of normal and sickle red cells and whole blood. As a result, the proportion of deoxyhemoglobin (which is responsible for sickling) is decreased at venous oxygen tensions and this is reflected by a sharply reduced sickle cell count in this range of oxygen pressures.
D000755:Anemia, Sickle Cell / Q000097:blood; D000986:Antisickling Agents; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011730:Pyridoxal / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000986:Antisickling Agents; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D011730:Pyridoxal; D010100:Oxygen
Anal Biochem. 1965 Apr;11:81-7
14328650
Arch Biochem Biophys. 1958 Oct;77(2):478-92
13584010
Biochemistry. 1972 Sep 12;11(19):3576-82
5053760
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2595-9
4517674
Nature. 1974 Aug 9;250(5466):502-4
4469603
Anal Biochem. 1973 Sep;55(1):245-8
4753150
J Clin Invest. 1973 Oct;52(10):2542-7
4729047
Arch Biochem Biophys. 1971 Jul;145(1):236-9
5123140
J Clin Invest. 1971 Sep;50(9):1901-9
5567559
Nature. 1968 Jun 8;218(5145):924-6
5681230