Cytogenetic evidence of clonal evolution in 5q- anemia.
The clinical homogeneity of myeloproliferative syndromes associated with a 5 q- marker can be contested, but nevertheless finds support in the 2 case reports we have cited. One of these observations of refractory anemia with partial myeloblastosis and 5 q- marker has shown a transformation into an acute myelomonocytic leukemia with clonal chromosomal evolution.
D000368:Aged; D000741:Anemia, Aplastic / Q000235:genetics*; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D002905:Chromosomes, Human, 4-5; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000235:genetics