Phospholipid monolayers and systemic lupus erythematosus.
A hypothesis is presented of the fundamental cause of the systemic lupus erythematosus. From a study of the molecular interaction of procainamide with phospholipid monolayers, it is proposed that the drug causes phospholipid loss from the cell membrane. Chronic phospholipid loss would lead to cell lysis and antinuclear antibody production.
D000779:Anesthetics, Local; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D011342:Procainamide / Q000009:adverse effects*; D011663:Pulmonary Surfactants; D013500:Surface Tension
D000779:Anesthetics, Local; D011663:Pulmonary Surfactants; D011342:Procainamide