The nucleotide sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs.
The complete sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs were determined by sequence analysis of full-length cDNAs. The single-stranded cDNAs were digested with the restriction endonuclease Hae III, and the two 3'-terminal fragments of 75 and 132 nucleotides, complementary to the 5' termini of the alpha- and beta-globin mRNAs, respectively, were isolated and sequenced. Including the initiation codon AUG, the untranslated 5' regions of human alpha- and beta-globin mRNAs contain 41 and 54 nucleotides, respectively, and exhibit striking homologies with the corresponding sequences in the rabbit. Human alpha- and beta-globin mRNAs have five bases in the region of the initiation codon that may form base pairs with the 3' terminus of 18S rRNA. Stable secondary structures with hairpin loops can be constructed in the untranslated 5' regions.
D001483:Base Sequence; D004247:DNA; D004262:DNA Restriction Enzymes; D005914:Globins / Q000096:biosynthesis*; D006801:Humans; D014176:Protein Biosynthesis; D012333:RNA, Messenger
D012333:RNA, Messenger; D005914:Globins; D004247:DNA; D004262:DNA Restriction Enzymes
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3047-51
268654
Nature. 1977 May 19;267(5608):279-81
865623
J Mol Biol. 1976 Nov 15;107(4):491-525
63556
J Biol Chem. 1977 Jul 25;252(14):5040-53
68958
J Biol Chem. 1977 Jul 25;252(14):5032-9
318159
J Biol Chem. 1977 Jul 25;252(14):5019-31
873928
Cell. 1977 Apr;10(4):571-85
558827
Cell. 1977 Apr;10(4):549-58
67896
Science. 1977 Apr 8;196(4286):200-2
847468
Science. 1977 Apr 8;196(4286):192-5
847466
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3146-50
61588
Cell. 1976 Dec;9(4 PT 2):747-60
189943
Cell. 1976 Dec;9(4 PT 2):733-46
1035137
J Mol Biol. 1976 Sep 5;106(1):37-53
972401
J Mol Biol. 1976 Sep 5;106(1):23-36
972400
Cell. 1976 Jun;8(2):163-82
61066
Nucleic Acids Res. 1977 Jan;4(1):1-15
325516
Science. 1977 Jan 28;195(4276):389-91
318762
Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4
265521
Ann N Y Acad Sci. 1974 Nov 29;241(0):290-309
4611306
Nat New Biol. 1972 Feb 9;235(58):163-7
4334193
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3502-6
4139714
Nat New Biol. 1973 Nov 14;246(150):40-1
4519026
Cell. 1975 Apr;4(4):367-78
47272
Nature. 1975 May 15;255(5505):255-6
1170497
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5140-4
1061099
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6
4598299
Nature. 1975 Oct 2;257(5525):421-2
809717
Nature. 1975 Aug 21;256(5519):624-8
807854
J Mol Biol. 1975 May 25;94(3):441-8
1100841
Proc Natl Acad Sci U S A. 1975 Dec;72(12):4734-8
1107998
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2555-8
1058473
Biochemistry. 1975 Aug 26;14(17):3787-94
1174504
J Biol Chem. 1968 Sep 10;243(17):4530-42
5684009