title: Genetic control of mitochondrial malate dehydrogenases: evidence for duplicated chromosome segments.
abstract: The genetic control of the major mitochondrial isoenzymes of malate dehydrogenase (L-malate:NAD+ oxidoreductase; EC 1.1.1.37) has been investigated in Zea mays. The mitochondrial isozymes are coded at four nuclear gene loci. Two of the loci (mdh1 and mdh2) are diallelic and tightly linked. The other two loci (mdh3 and mdh4) appear to have arisen by duplication of the chromosome segment carrying mdh1 and mdh2, but are not linked to them. The segregation of such a duplicate segment can explain anomalous backcross and F2 segregation ratios.
mesh_terms: D000483:Alleles; D005075:Biological Evolution; D002869:Chromosome Aberrations; D003593:Cytoplasm / Q000201:enzymology; D005796:Genes; D008040:Genetic Linkage; D007527:Isoenzymes / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology*; D008954:Models, Biological; D003313:Zea mays / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D008291:Malate Dehydrogenase
references.citation: Biochem Genet. 1970 Apr;4(2):253-7
references.pmid: 4193184
references.citation: Arch Biochem Biophys. 1975 Dec;171(2):575-85
references.pmid: 1200641
references.citation: Plant Physiol. 1970 Mar;45(3):249-54
references.pmid: 4316376
references.citation: Arch Biochem Biophys. 1974 Apr 2;161(2):335-53
references.pmid: 4365553
references.citation: Genetics. 1974 Jan;76(1):64-72
references.pmid: 4818265
references.citation: Proc Natl Acad Sci U S A. 1968 Sep;61(1):253-60
references.pmid: 4880609
references.citation: Biochemistry. 1971 Nov 23;10(24):4422-5
references.pmid: 4946922
references.citation: J Biol Chem. 1970 Nov 25;245(22):5927-40
references.pmid: 4991846
references.citation: Biochem Genet. 1971 Jun;5(3):211-21
references.pmid: 5088798
references.citation: Proc Natl Acad Sci U S A. 1966 Jun;55(6):1600-8
references.pmid: 5227678
references.citation: Science. 1965 Aug 27;149(3687):936-43
references.pmid: 5318249
references.citation: Experientia. 1970;26(7):734-6
references.pmid: 5431133
references.citation: Biochem Genet. 1970 Dec;4(6):707-18
references.pmid: 5496232
references.citation: Science. 1966 Sep 16;153(3742):1408-10
references.pmid: 5917778
references.citation: Nature. 1966 Apr 30;210(5035):489-91
references.pmid: 5960510
references.citation: Nature. 1967 Aug 12;215(5102):761-2
references.pmid: 6059555
references.citation: N Engl J Med. 1964 Aug 13;271:352-7
references.pmid: 14171805
references.citation: Proc Natl Acad Sci U S A. 1969 Jan;62(1):104-11
references.pmid: 16591725
references.citation: Plant Physiol. 1968 Apr;43(4):622-8
references.pmid: 16656816
references.citation: Genetics. 1972 Feb;70(2):337-40
references.pmid: 17248568
references.citation: Biochim Biophys Acta. 1975 Apr 19;384(2):293-306
references.pmid: 1125253
references.citation: Genetics. 1975 May;80(1):1-11
references.pmid: 1137965
references.citation: Proc Natl Acad Sci U S A. 1972 Jun;69(6):1371-4
references.pmid: 4260903