title: [Clinical significance of cationic proteins of leukocyte lysosomes: cationic leukocyte antigen (CLA) as a marker of blast crisis in chronic myelocytic leukaemia (author's transl)].
abstract: Cationic leukocyte antigen (CLA) was estimated in urine of acute and chronic leukaemics using quantitative immuno-precipitation techniques. The studies demonstrated that CLA is a marker of the (myelo-) blast crisis in patients with chronic myelocytic leukaemia (CML). By these studies the value of the determination of CLA for the differential diagnosis of acute myeloblastic leukaemia versus initial (myelo-) blast crisis in CML and the lymphatic leukaemias, respectively, was evident. The terminal blastic transformation in CML was indicated early by an elevation of the urinary CLA-level. The blast-crisis was accompanied by a heavy CLA-uria. The results are documented by demonstration of special studies of characteristic cases and discussed in the light of recent results of immunological and cytochemical findings on the nature of blast crisis in CML.
mesh_terms: D000368:Aged; D000941:Antigens / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000276:immunology / Q000652:urine; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000276:immunology / Q000652:urine; D007962:Leukocytes / Q000276:immunology*; D008247:Lysosomes / Q000276:immunology; D008875:Middle Aged; D011087:Polycythemia Vera / Q000175:diagnosis; D055728:Primary Myelofibrosis / Q000175:diagnosis
chemical_list: D000941:Antigens
references.citation: Wien Med Wochenschr. 1959 Feb 28;109(9):179-82
references.pmid: 13648385
references.citation: Nature. 1973 Oct 19;245(5425):379-80
references.pmid: 4206051
references.citation: Immunochemistry. 1965 Sep;2(3):235-54
references.pmid: 4956917
references.citation: Klin Wochenschr. 1958 May 15;36(10):462-8
references.pmid: 13550859
references.citation: Blood. 1959 Jul;14(7):870-81
references.pmid: 13662330
references.citation: Nature. 1972 Feb 4;235(5336):274-5
references.pmid: 4551178
references.citation: Cancer. 1975 Jan;35(1):199-207
references.pmid: 45888
references.citation: Nature. 1975 Dec 4;258(5534):454-6
references.pmid: 1059878
references.citation: Klin Wochenschr. 1972 Mar 1;50(5):250-7
references.pmid: 4503294
references.citation: J Exp Med. 1966 Nov 1;124(5):921-52
references.pmid: 5224561
references.citation: Am J Med Sci. 1958 Jun;235(6):689-701 passim
references.pmid: 13533433
vernacular_title: Klinische Wertigkeit von kationischen lysosomalen Leukozytenproteinen: Bedeutung der immunologischen Bestimmung von Kationischem Leukozytenantigen (CLA) für die Diagnose der Blastenkrise bei chronischer Myelose.