title: Mode of insertion of the sucrase-isomaltase complex in the intestinal brush border membrane: implications for the biosynthesis of this stalked intrinsic membrane protein.
abstract: Unlike other intrinsic plasma membrane proteins the sucrase-isomaltase complex is associated with the intestinal brush border membrane through a highly hydrophobic segment located not far from the N-terminal of one subunit (isomaltase). This observation calls for additions and/or modifications to the generally accepted scheme of biosynthesis of plasma membrane intrinsic proteins.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D004285:Dogs; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology*; D008565:Membrane Proteins / Q000096:biosynthesis*; D008871:Microvilli / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000096:biosynthesis*; D011817:Rabbits; D013394:Sucrase-Isomaltase Complex / Q000096:biosynthesis*
chemical_list: D000596:Amino Acids; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D013394:Sucrase-Isomaltase Complex