Disposition in rats of the carbohydrate polymer in Ferastral--an iron-poly (sorbitol-gluconic acid) complex.
The disposition and pharmacokinetics in rats of 14C-sorbitol-Ferastral has been studied as an initial step towards elucidating the metabolic fate of the polymeric organic moiety. The period of time studied was 24 h. Following i.v. administration of a dose corresponding to 10 mg/kg of iron approximately 60% of the isotope was found in the urine after this period of time. A further 3% was demonstrated in the faeces whilst the expired air accounted for about 10% in the form of 14CO2. Thus, a relatively large proportion of the radiolabel was promptly excreted via the kidneys whilst the expired air and probably bile constituted secondary excretion routes. The physico-chemical nature of the urinary product was similar to the parent carbohydrate compound. The residual 14C radioactivity was distributed mainly between the liver, which contained approximately 45% of the retained label, carcass with 36% and large intestine with 7%. The plasma disappearance pattern was biphasic. Similar experiments with the 14C-sorbitol polymer starting material were performed for purposes of comparison.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004338:Drug Combinations; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011108:Polymers; D051381:Rats; D013012:Sorbitol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine
D004338:Drug Combinations; D011108:Polymers; D002245:Carbon Dioxide; D013012:Sorbitol; D007501:Iron