title: The effect of central nervous system stimulants on Tourette syndrome.
abstract: A survey of patients with  Tourette syndrome uncovered 32 who had been exposed to central nervous system stimulants. In 17 (53%) of these patients, symptoms were markedly accentuated by the drugs. Two patients whose Tourette syndrome developed suddenly when methylphenidate was administered are also reported.
mesh_terms: D002675:Child, Preschool; D006801:Humans; D006948:Hyperkinesis / Q000188:drug therapy; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects; D005879:Tourette Syndrome / Q000139:chemically induced*
chemical_list: D008774:Methylphenidate