Suppression of production of mouse 28S ribosomal RNA in mouse-human hybrids segregating mouse chromosomes.
Mouse-human somatic cell hybrids that lose (segregate) human chromosomes produce only mouse 28S ribosomal RNA even when they retain copies of the human chromosomes that contain the genes for 28S ribosomal RNA. In contrast, mouse-human hybrid cells that segregate mouse chromosomes produce only human 28S ribosomal RNA even when they have retained copies of mouse chromosomes that contain the 28S ribosomal RNA genes.
D000818:Animals; D002460:Cell Line; D002875:Chromosomes / Q000378:metabolism*; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism*; D007621:Karyotyping; D051379:Mice; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D014158:Transcription, Genetic
D012335:RNA, Ribosomal
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