title: Molecular evolution of human and rabbit beta-globin mRNAs.
abstract: The primary structures of human and rabbit beta-globin mRNAs are compared. Using as a standard the extent of nucleotide substitutions inferred from the hypervariable amino acid residues of fibrinopeptides A and B, which are thought to change largely by neutral evolution, we show that not all silent mutations in globin mRNA are neutral. The divergence of the sequences is limited in part by the selective usage of synonymous codons. The divergent nucleotides tend to be distributed nonrandomly: in the coding region silent substitutions are most rare in segments that are also deficient in substitutions leading to replacements.
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D003062:Codon; D005914:Globins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000235:genetics*; D011817:Rabbits
chemical_list: D003062:Codon; D012333:RNA, Messenger; D005914:Globins
references.citation: Nature. 1971 Sep 10;233(5315):118-9
references.pmid: 16063236
references.citation: Biochem Biophys Res Commun. 1976 Dec 20;73(4):1083-93
references.pmid: 15625885
references.citation: Biochim Biophys Acta. 1964 Jun 8;86:535-42
references.pmid: 14192905
references.citation: Nature. 1977 May 19;267(5608):275-6
references.pmid: 865622
references.citation: J Biol Chem. 1977 Jul 25;252(14):5040-53
references.pmid: 68958
references.citation: Cell. 1977 Apr;10(4):571-85
references.pmid: 558827
references.citation: Cell. 1977 Apr;10(4):559-70
references.pmid: 67897
references.citation: Cell. 1977 Apr;10(4):549-58
references.pmid: 67896
references.citation: Prog Nucleic Acid Res Mol Biol. 1976;19:205-20
references.pmid: 1019345
references.citation: J Mol Biol. 1976 Jul 25;105(1):15-37
references.pmid: 186607
references.citation: Science. 1977 Jan 28;195(4276):389-91
references.pmid: 318762
references.citation: Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4
references.pmid: 265521
references.citation: Nature. 1977 Feb 24;265(5596):687-95
references.pmid: 870828
references.citation: J Mol Evol. 1976 Aug 3;8(2):117-35
references.pmid: 787545
references.citation: J Mol Biol. 1976 Nov;108(1):1-23
references.pmid: 1003479
references.citation: Science. 1976 Dec 10;194(4270):1173-4
references.pmid: 996548
references.citation: J Mol Biol. 1976 Oct 5;106(4):1047-60
references.pmid: 978743
references.citation: Proc Natl Acad Sci U S A. 1973 Jun;70(6):1886-90
references.pmid: 4124307
references.citation: Proc Natl Acad Sci U S A. 1973 Jun;70(6):1809-13
references.pmid: 4124305
references.citation: Nature. 1974 Feb 1;247(5439):265-7
references.pmid: 4131865
references.citation: Nature. 1973 Dec 14;246(5433):389-95
references.pmid: 4202790
references.citation: Nat New Biol. 1971 Feb 3;229(5):142-3
references.pmid: 5280094
references.citation: Biochemistry. 1975 Sep 23;14(19):4209-15
references.pmid: 241373
references.citation: Eur J Biochem. 1975 Sep 1;57(1):147-57
references.pmid: 1175639
references.citation: J Mol Evol. 1971;1(1):26-45
references.pmid: 4377446
references.citation: Fed Proc. 1976 Jan;35(1):23-35
references.pmid: 1107072
references.citation: Annu Rev Genet. 1972;6:47-70
references.pmid: 4581487
references.citation: J Theor Biol. 1974 Jan;43(1):211-25
references.pmid: 4591738
references.citation: Nature. 1972 Dec 15;240(5381):395-8
references.pmid: 4564316
references.citation: Nature. 1972 May 12;237(5350):82-8
references.pmid: 4555447
references.citation: Ann N Y Acad Sci. 1974 Nov 29;241(0):436-8
references.pmid: 4530669
references.citation: Proc Natl Acad Sci U S A. 1974 Jul;71(7):2848-52
references.pmid: 4527913
references.citation: Nature. 1971 Feb 12;229(5285):467-9
references.pmid: 4925204
references.citation: Nature. 1975 Feb 20;253(5493):603-8
references.pmid: 1089897
references.citation: J Mol Evol. 1975 Dec 31;7(1):1-57
references.pmid: 765485
references.citation: J Mol Biol. 1975 May 25;94(3):441-8
references.pmid: 1100841
references.citation: Nature. 1976 Apr 8;260(5551):500-7
references.pmid: 1264203
references.citation: Science. 1969 May 16;164(3881):788-98
references.pmid: 5767777
references.citation: Nature. 1968 Feb 17;217(5129):624-6
references.pmid: 5637732
references.citation: J Theor Biol. 1965 Mar;8(2):357-66
references.pmid: 5876245