Oxygen consumption in canine skeletal muscle following massive saline infusion.
To study the effect of interstitial edema on tissue oxygen transport, we infused buffered isotonic saline solution at a rate of 200 ml/kg/hr into mongrel dogs for two hours, measuring oxygen delivery and consumption in a skinned, innervated hindlimb. Hematocrit dropped gradually to 10.8 +/- 3.9%. Muscle water content increased 13% (P less than 0.05). However, oxygen consumption did not change significantly from control of 0.228 +/- 0.029 ml/min/100 gm. Femoral venous oxygen tension fell from control of 62.6 +/- 2.6 mm Hg to 31.4 +/- 2.3 mm Hg. Mean arterial flow increased to nearly twice the control level of 12.5 +/- 1.1 ml/min/100 gm and fell gradually, with the sustained 50% drop in vascular resistance largely explained by expected decreases in blood viscosity. We conclude that interstitial edema did not cause a significant defect in canine skeletal muscle oxygen utilization.
D000818:Animals; D004285:Dogs; D004487:Edema / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D004909:Erythrocyte Indices; D006454:Hemoglobins / Q000032:analysis; D006614:Hindlimb; D009132:Muscles / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D012965:Sodium Chloride
D006454:Hemoglobins; D012965:Sodium Chloride; D010100:Oxygen