title: [The effect of bioceramics (calcium phosphate ceramics) on cultured rabbit fibroblasts].
abstract: Cell compatibility of biodegradable calciumphosphate ceramic material was tested in rabbit fibroblasts cultivated on cover slips. Culture growth was in no way inhibited during 12 days of cultivation in the presence of ceramics. The fibroblasts showed phagocytosis of ceramic particles and were able to undergo mitosis as long as the cytoplasm was not overloaded with particles. After incorporation of ceramics, impairment of cytoplasmic division could lead to the formation of polyploid and polynuclear cells. Death of overloaded cells was observed only in the cell-and ceramic-dense center of the cultures from the 10th day on, and may be considered as natural decay of aged cells. The cell- and tissue-compatibility of bioceramic material observed in experimental surgery is thus confirmed.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002130:Calcium Phosphates / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000276:immunology*; D008938:Mitosis; D010587:Phagocytosis; D011817:Rabbits
chemical_list: D002130:Calcium Phosphates
vernacular_title: Die Wirkung von Biokeramik (Kalziumphosphatkeramik) auf kultivierte Kaninchenfibroblasten.