A comparison of oral theophylline and oral salbutamol in exercise-induced asthma.
Ten patients with exercise-induced asthma were premedicated with oral salbutamol and oral theophylline on separate occasions before performing a standardised exercise test. Although both agents produced bronchodilatation, reflected by increases in peak expiratory flow rates (PEFR) at rest, they were generally ineffective in preventing an abnormal post-exercise fall in PEFR. Only one patient was afforded protection by salbutamol and another two patients by theophylline.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D005082:Physical Exertion; D010919:Placebos; D013806:Theophylline / Q000008:administration & dosage* / Q000627:therapeutic use
D010919:Placebos; D013806:Theophylline; D000420:Albuterol