Mitotic activity of the granulopoietic precursor cells in the peripheral blood in chronic myeloid leukaemia.
The mitotic indices (MI) of granulopoietic precursor cells in peripheral blood and bone marrow were studied in 38 patients with typical chronic myeloid leukaemia (CML) in the chronic phase. The MI in the peripheral blood were very low, in the median 0.07%, compared to those in the bone marrow with a median of 1.07%. The blood MI were significantly increasing with raising WCC and the values of the MI above the median were combined with short survival times. The bone marrow MI were negatively correlated to the blood MI and it is suggested that this is a sign of an increased exchange of cells between bone marrow and blood.
D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells; D005260:Female; D006098:Granulocytes; D006410:Hematopoiesis; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D011379:Prognosis