The mimimum inactivated cell ratio: a concept for the estimation of biological effectiveness of hyperthermic treatment of tissue.
The experimental conditions used to investigate the dose-effect relationships for hyperthermic treatment of cells in vitro cannot be realized in vivo. Thus it is not possible to predict the cell inactivation due to a hyperthermic treatment of the tissue in vivo, using the in vitro dose-effect-relationships. However, the in vitro dose-effect curves in combination with the temperature field in vivo make it possible to calculate the lower limit of the biological effect, the minimum inactivated cell ratio (MIR). This magnitude is of clinical relevance. The present paper gives the algorithm for the calculation of the MIR, and discusses the influence of the heat supply time on the local biological effect for a model with spherical symmetry.
D002470:Cell Survival; D003972:Diathermy; D006801:Humans; D009369:Neoplasms / Q000628:therapy*