The optimum duration of systemic antibiotic administration in the treatment of experimental peritonitis.
The duration of antibiotic therapy for peritonitis is commonly decided on an empirical basis. There is obvious advantage in determining the shortest, yet most effective, period for such drug therapy. This study is a comparison of short-course and long-course antibiotic administration following periotonitis produced by experimental rupture of the rabbit appendix.
D000038:Abscess / Q000382:microbiology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001065:Appendix / Q000382:microbiology; D001419:Bacteria / Q000302:isolation & purification; D002981:Clindamycin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D008297:Male; D010538:Peritonitis / Q000188:drug therapy* / Q000401:mortality; D011817:Rabbits; D014031:Tobramycin / Q000008:administration & dosage* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D014031:Tobramycin