Insulin-induced hyperphagia in alloxan-diabetic rats fed a high-fat diet.
Alloxan-diabetic rats fed a standard, low-fat diet lost body weight and were hyperphagic; those fed a high-fat diet lost comparable amounts of weight, but did not overeat compared to normal animals. When given injections of protamine-zinc insulin, all diabetic rats gained weight; however, while those fed the low-fat reduced food intake from elevated levels, diabetics fed the high-fat diet became hyperphagic. Diabetic rats maintained on a high-fat diet increased food intake during long-term insulin treatment sooner and to a greater extent than normal controls. These findings are interpreted in light of the effects of insulin on storage and supply of metabolic fuels.
D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D004041:Dietary Fats / Q000627:therapeutic use*; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D049528:Insulin, Long-Acting / Q000009:adverse effects*; D051381:Rats
D004041:Dietary Fats; D049528:Insulin, Long-Acting