title: Ventricular tachycardia-flutter associated with disopyramide therapy: a report of three cases.
abstract: Three patients developed episodes of ventricular tachycardia and/or flutter-fibrillation while receiving disopyramide (Norpace). Syncope was the presenting complaint in all of them. The arrhythmias did not recur after disopyramide was discontinued. The Q-T interval was markedly prolonged in all three patients. One patient developed syncope associated with both quinidine and Norpace therapy. It is postulated that disopyramide, like quinidine, may provoke ventricular flutter-fibrillation in sensitive patients by similar mechanisms.
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D004206:Disopyramide / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D011725:Pyridines / Q000009:adverse effects*; D011802:Quinidine / Q000009:adverse effects; D013575:Syncope / Q000139:chemically induced; D013610:Tachycardia / Q000139:chemically induced*
chemical_list: D011725:Pyridines; D004206:Disopyramide; D011802:Quinidine