Nonintercalative binding of ethidium bromide to nucleic acids: crystal structure of an ethidium--tRNA molecular complex.
X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary structure. This is contrary to the expected interacalative binding to the double-helical regions.
D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D004996:Ethidium / Q000378:metabolism*; D008958:Models, Molecular; D012343:RNA, Transfer / Q000378:metabolism*; D014961:X-Ray Diffraction
D012343:RNA, Transfer; D004996:Ethidium
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