title: Reversible skeletal muscle damage after administration of local anesthetics with and without epinephrine.
abstract: Local anesthetic preparations with and without epinephrine, which are in common clinical use, produced reversible skeletal muscle damage in the rat after a single local administration. In addition, epinephrine alone, in concentrations of more than 1:200,000, caused similar but less extensive damage.
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000009:adverse effects*; D007273:Injections, Intramuscular / Q000009:adverse effects; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009336:Necrosis / Q000139:chemically induced; D011318:Prilocaine / Q000009:adverse effects*; D051381:Rats; D012038:Regeneration; D013997:Time Factors; D014313:Trismus / Q000209:etiology
chemical_list: D011318:Prilocaine; D008012:Lidocaine; D004837:Epinephrine