title: D-penicillamine-induced mucocutaneous lesions with features of pemphigus.
abstract: Penicillamine (beta1 beta2 dimethylcysteine) is the drug of choice in the therapeutic management of Wilson's disease and cystinuria and has been used in the treatment of some heavy-metal intoxications. Recent studies have shown that it is efficacious in patients with rheumatoid arthritis. Side effects include sensitivity reactions, nephrotoxicity, bone-marrow suppression, hypogeusia, skin lesions, and the formation of autoantibodies. Two cases are described with the features of pemphigus which were attributed to penicillamine therapy.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects* / Q000276:immunology; D010392:Pemphigus / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D010396:Penicillamine