[Role of the prostaglandin system in the monoaminergic control of prolactin release in the rat].
In ovariectomized rats treated with estradiol benzoate, the pre-treatment with bromocriptine or metergoline on increase of PRL secretion induced by some prostaglandins has been investigated. The PGs used were able to hinder the drop in PRL levels induced by metergoline, a blocker of 5-HT receptors, but not that produced by bromocriptine, a dopamine receptor agonist. Therefore it is possible to suppose that the PGs are involved in the monoaminergic hypothalamic regulation of the PRL secretion.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D008711:Metergoline / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011453:Prostaglandins / Q000502:physiology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology
D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D008711:Metergoline; D001971:Bromocriptine; D011388:Prolactin
Ruolo del sistema prostaglandinico nel controllo monoaminergico della liberazione di prolattina nel ratto.