Comparison of metabolic effect of ammonia and adrenaline infusions in sheep.
Intravenous infusions of ammonium chloride (62.3 mumol.kg-1.min-1) for 30 min caused a significant increase in blood glucose, lactate, pyruvate and free fatty acid (FFA) levels. A similar effect was also observed during infusion of adrenaline. Propanolol--a beta-receptor blocking agent--completely prevented the rise of blood pyruvate and lactate after adrenaline when 8.3 microgram.kg-1.min-1 of propranolol were infused, but not after NH4Cl administration. Lipolytic actions of adrenaline were completely prevented but that of NH4Cl was only significantly diminished by blockade of beta-receptors with propranolol. It was concluded that the influence of ammonium ions on blood lactate and pyruvate and FFA was not entirely mediated by adrenaline.
D000643:Ammonium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose; D004837:Epinephrine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D007263:Infusions, Parenteral; D007773:Lactates / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology; D011773:Pyruvates / Q000097:blood*; D012756:Sheep / Q000097:blood*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011773:Pyruvates; D000643:Ammonium Chloride; D011433:Propranolol; D004837:Epinephrine