Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J.
The formation and excision of benzo[a]pyrene-deoxyguanosine adducts in metabolizing baby hamster kidney cells (21/C13) and secondary mouse embryo fibroblasts (C57BL/6J) was investigated. Both diastereomeric adducts, N2-(10-(7beta,8alpha,9alpha-trihydroxy-7, 8, 9, 10 tetrahydrobenzo[a]-7,8,9,10-tetrahydrobenzo[a]pyrene)yl)deoxyguanosine, were detected in both cell lines and both cell lines were capable of excising these lesions, albeit with low efficiency.
D001580:Benzopyrenes / Q000378:metabolism*; D002460:Cell Line; D004260:DNA Repair; D003853:Deoxyribonucleosides; D006151:Guanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D007700:Kinetics
D001580:Benzopyrenes; D003853:Deoxyribonucleosides; D006151:Guanosine
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