Distribution of the carbohydrate polymer in 14C-labelled iron-poly (sorbitol-gluconic acid) complex after intramuscular administration in normal and anaemic rats.
The carbohydrate polymer in an iron-poly (sorbitol-gluconic acid) complex was prepared by using uniformly labelled 14C-sorbitol or 14C-gluconic acid. The distribution of these complexes 7, 14 and 28 days after administration has been followed in non-anaemic and anaemic rats. Most of the 14C from the labelled complexes was found in the expired CO2, faeces and urine. Twenty-eight days after injection of 14C-labelled Ferastral, less than 13% of the given dose of either 14C-sorbitol or 14C-gluconic acid labelled preparation could be found in the body. There was no specific accumulation of 14C in any organ except in the bones, where 3% of the given dose could be seen 28 days after 14C-gluconic acid labelled Ferastral to both non-anaemic and anaemic animals.
D000740:Anemia / Q000378:metabolism; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004338:Drug Combinations; D005243:Feces / Q000032:analysis; D005942:Gluconates / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D007273:Injections, Intramuscular; D007501:Iron / Q000008:administration & dosage* / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D011108:Polymers; D051381:Rats; D012867:Skin / Q000378:metabolism; D013012:Sorbitol / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine
D004338:Drug Combinations; D005942:Gluconates; D011108:Polymers; D002245:Carbon Dioxide; D013012:Sorbitol; D007501:Iron