Patterns of plasma iron fractions after intramuscular Ferastral.
The distribution of plasma iron fractions after intramuscular Ferastral is described for times up to eight days after injection. Transferrin-bound iron reaches a peak value in 4-8 hours and falls towards normal values while circulating iron-complex concentration remains high. The peak concentration of iron-complex occurs 8-24 hours after injection, and is virtually cleared from the circulation in 6-8 days. An approximate T 1/2 of 30 hours for plasma Ferastral is deduced from the rate of fall from peak values. UIBC values fell as transferrin-bound iron increased, but did not reach zero in any subject studied.
D004338:Drug Combinations; D005942:Gluconates / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood; D013012:Sorbitol / Q000008:administration & dosage / Q000097:blood; D013997:Time Factors; D014168:Transferrin / Q000032:analysis
D004338:Drug Combinations; D005942:Gluconates; D014168:Transferrin; D013012:Sorbitol; D007501:Iron