Evidence for distinct lymphocytic and monocytic populations in a patient with terminal transferase--positive acute leukemia.
Two distinct cell populations with lymphoblastic and monocytic characteristics were separated and characterized by multiple cell markers in a patient with terminal transferase-positive acute acute leukemia. The clinical course and sequential cell marker studies were consistent with the interpretation of a defect at the level of a common stem cell giving rise to a terminal transferase--positive lymphoblastic cell population at diagnosis and, following initial therapy, a terminal transferase--negative monocytic population.
D000328:Adult; D002469:Cell Separation; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood; D007948:Leukemia, Monocytic, Acute / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D008214:Lymphocytes; D009000:Monocytes; D009713:Nucleotidyltransferases / Q000097:blood*; D011241:Prednisone / Q000627:therapeutic use; D013866:Thioguanine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D005437:Flucytosine; D009713:Nucleotidyltransferases; D013866:Thioguanine; D011241:Prednisone