title: [Liver injury during combined chemotherapy of acute leukemias].
abstract: The authors observed 70 patients with acute leukemia treated by polychemotherapy. In 2 patients the signs of severe liver damage were found. The occurrence, course and results of laboratory tests suggested Purinethol predominantly as the cause of development of these alterations. The complication did not occur frequently in our patients. The changes regressed in a satisfactory way after the withdrawal of the hepatotoxic cytostatic from the therapy.
mesh_terms: D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury; D004359:Drug Therapy, Combination; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D015122:Mercaptopurine / Q000008:administration & dosage / Q000009:adverse effects*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014750:Vincristine; D015122:Mercaptopurine; D008727:Methotrexate
vernacular_title: Ostećenje jetre u toku polihemioterapije akutnih leukemija.