title: Morphometry of the renal corpuscle during normal postnatal growth and compensatory hypertrophy. A light microscope study.
abstract: Renal corpuscles from the juxtamedullary and subcapsular regions of the renal cortex were morphometrically analyzed in young rats and in adult rats that had been unilaterally nephrectomized or sham-operated at an early age. Mean corpuscular volumes increased 4.5-fold during normal development, and 7.7-fold as a result of compensatory hypertrophy in both cortical regions. Relative and absolute volumes were determined for Bowman's space, the glomerular tuft, and five glomerular components: epithelial, endothelial, and mesangial cells, capillaries, and the filtration membrane. Normal and hypertrophic enlargement of Bowman's space was slightly greater than glomerular growth, and the growth response of subcapsular glomeruli was greater than that of juxtamedullary glomeruli. The ratio of mean glomerular volumes between outer and inner glomeruli was 1:2 in both adult groups. Both adult groups also developed nearly identical proportions of all glomerular component structures, representing a relative decrease of epithelial cells and increase of capillaries compared to the young animals. Normal and hypertrophic maturation involved absolute increases in all glomerular cell populations, the length of capillary loops and the surface area of the filtration membrane, all nearly in proportion to the respective four- and seven-fold increases in glomerular volume. Changes in the filtration surface area are consistent with published data for glomerular filtration rates in normal and hypertrophied kidneys. The mean cell size in epithelial and mesangial populations doubled during growth, but was not greater than normal in mononephrectomized rats. Hyperplasia among all populations of glomerular cells is indicated in normal growth, and to a greater extent in compensatory renal hypertrophy.
mesh_terms: D000375:Aging; D000818:Animals; D006984:Hypertrophy; D007672:Kidney Cortex / Q000166:cytology / Q000254:growth & development* / Q000473:pathology; D007678:Kidney Glomerulus / Q000166:cytology / Q000254:growth & development; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
references.citation: Lab Invest. 1971 Jun;24(6):499-503
references.pmid: 5090999
references.citation: Yale J Biol Med. 1970 Dec;43(3):164-72
references.pmid: 5499193
references.citation: J Clin Invest. 1971 Apr;50(4):779-95
references.pmid: 5547275
references.citation: J Cell Biol. 1968 Apr;37(1):27-46
references.pmid: 5645844
references.citation: Lab Invest. 1968 Jun;18(6):700-8
references.pmid: 5667867
references.citation: Microvasc Res. 1973 Nov;6(3):273-85
references.pmid: 4149031
references.citation: Am J Med. 1973 Mar;54(3):281-9
references.pmid: 4571744
references.citation: Am J Physiol. 1972 Nov;223(5):1184-90
references.pmid: 4654351
references.citation: J Physiol. 1973 Jan;228(1):193-202
references.pmid: 4686024
references.citation: Am J Physiol. 1973 Nov;225(5):1247-51
references.pmid: 4745228
references.citation: J Clin Invest. 1973 Nov;52(11):2885-95
references.pmid: 4748514
references.citation: J Clin Invest. 1974 Jan;53(1):279-87
references.pmid: 4808641
references.citation: Kidney Int. 1974 Feb;5(2):122-30
references.pmid: 4815218
references.citation: Kidney Int. 1974 Feb;5(2):131-6
references.pmid: 4815219
references.citation: Lab Invest. 1974 May;30(5):657-63
references.pmid: 4825823
references.citation: Pflugers Arch. 1974;346(4):279-90
references.pmid: 4856390
references.citation: Lab Invest. 1969 Sep;21(3):269-75
references.pmid: 4897638
references.citation: Int Rev Cytol. 1969;26:235-302
references.pmid: 4899604
references.citation: Lab Invest. 1968 Dec;19(6):573-9
references.pmid: 5707113
references.citation: Am J Pathol. 1966 Jul;49(1):1-13
references.pmid: 5944761
references.citation: Nephron. 1966;3(6):352-65
references.pmid: 5958781
references.citation: Am J Pathol. 1967 Jan;50(1):1-14
references.pmid: 6017684
references.citation: Z Wiss Mikrosk. 1961 Dec;65:70-82
references.pmid: 13889833
references.citation: Am J Pathol. 1927 Jul;3(4):329-342.1
references.pmid: 19969751