title: Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA.
abstract: Separated strands of adenovirus DNA were annealed with early cytoplasmic RNA and visualized in the electron microscope. DNA-RNA duplex regions within the DNA filaments could be recognized by their heavy contour. This contour was often interrupted at distinct locations by loops of displaced, single-stranded DNA. Loops have been observed and mapped in all four early regions of the genome. The structures appear to signal hitherto unknown mechanisms of eukaryotic gene expression.
mesh_terms: D000256:Adenoviridae / Q000032:analysis*; D004279:DNA, Viral; D008854:Microscopy, Electron; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D012313:RNA
chemical_list: D004279:DNA, Viral; D012313:RNA
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