[Kinetics of 14C-cholic acid in the baboon under normal conditions and in cholestasis. Description and validity of a multicompartmental model].
A multicompartmental model was applied to the study of the plasmatic and biliary kinetics of the 14C-Cholic acid intravenously injected into a baboon in normal and cholestatic condition. For the evaluation of transfer rates FORTAN IV procedures were used, utilizing Powell method. The degree of fitting was: in normal condition in serum 7% for free and 35% for conjugated Cholic acid, while in bile 5% and 4% respectively; in serum in cholestatic condition 7% for free and 12% for conjugates. The high degree of fitting and reliable estimation of transfer rates suggest that the multicompartmental model applied represents most likely the physio-pathological conditions studied.
D000818:Animals; D001646:Bile / Q000032:analysis; D002779:Cholestasis / Q000378:metabolism*; D002793:Cholic Acids / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D005260:Female; D010215:Papio / Q000378:metabolism*
D002793:Cholic Acids
Cinetica dell'acido colico-14C nel barbuino in condizioni fisioloigiche e di colestasi. Descrizione e validita' di un modello multicompartimentale.