Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia.
A one-hour D-xylose absorption test was performed on 18 children with acute lymphoblastic leukaemia. Xylose absorption was normal in children who had not received methotrexate, but there was a significant degree of malabsorption in those who had taken methotrexate within the previous seven days. There was a progressive and significant increase in malabsorption related to the cumulative dose of methotrexate. These findings provide further evidence that regular methotrexate treatment every seven days is more toxic than if it is more widely spaced. The spacing of treatment is currently under investigation.
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008286:Malabsorption Syndromes / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D014994:Xylose / Q000378:metabolism
D014994:Xylose; D008727:Methotrexate
Am J Dig Dis. 1959 Sep;4:700-5
13831769
Cancer Treat Rev. 1976 Mar;3(1):17-41
1068746
Lancet. 1973 Nov 10;2(7837):1043-5
4127308
N Engl J Med. 1972 Oct 12;287(15):769-77
4506615
Arch Dis Child. 1976 Jul;51(7):489-93
1067058
Br J Haematol. 1976 Jun;33(2):179-88
1063593
Acta Pharmacol Toxicol (Copenh). 1976 May;38(5):450-64
989248
Biochem Pharmacol. 1966 Oct;15(10):1479-89
5971804