Regional gastric blood flow in cynomolgus monkeys with hemorrhagic shock and resuscitation.
Five anesthetized cynomolgus monkeys were subjected to hemorrhagic shock (42 +/- 3 mm Hg) for four hours and then resuscitated with shed blood and intravenous fluids to restore mean arterial pressure and arterial pH to control levels. Regional gastric blood flow was measured by radioactive microspheres. Responses were similar in all regions, except mucosal blood flow increased significantly (from 20.1 +/- 5.1 to 42.1 +/- 7.6 ml/min 100 gm of tissue) in response to resuscitation in the antrum but not in the fundus or corpus. This difference in response may explain the occurrence of stress ulcers in the proximal stomach with sparing of the antrum.
D000818:Animals; D005260:Female; D006439:Hemodynamics; D008252:Macaca fascicularis; D008297:Male; D008863:Microspheres; D012039:Regional Blood Flow; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013270:Stomach / Q000098:blood supply*