Polyamine and magnesium effects on mitochondrial respiration in control and heat-acclimated rats.
Studies were made of polyamine and Mg++ effects on rat liver mitochondrial alpha ketoglutarate oxidase (alphaKGO) and succinoxidase (SO). High spermidine levels suppress S3 and S4 of alphaKGO at 0.6-1.17 mM Mg++: some combinations of it and Mg++ increase the respiratory control ratio (RCR). Spermine suppresses S4 of alphaKGO and increases the RCR but suppresses the RCR of SO at high levels. In heat-acclimated (HA) animals in which we have studied only spermine effects on alphaKGO, RCRs of HA rats are greatly increased compared to those of controls.
D000064:Acclimatization; D000818:Animals; D006358:Hot Temperature; D007656:Ketoglutaric Acids / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology
D007656:Ketoglutaric Acids; D011073:Polyamines; D013096:Spermine; D008274:Magnesium; D013095:Spermidine