title: Multivariate analysis of the septal syndrome.
abstract: Since recent reviews of the behavioural effects of septal lesions agree that more than one explanatory concept is required, a multivariate analysis of the septal syndrome has been made. A total of 127 rats have been tested 73 with septal lesions and 54 controls. The rats were tested in a standard test battery consisting of a residential maze, spontaneous alternation, spatial learning, approach/avoidance conflict and one-way active avoidance. Factor analyses reveal a complex change in the factor structure after septal lesions. None of the previous explanations of septal functions receives unequivocal support. The findings do not exclude the possibility that septal lesions interfere with a few general behaviour mechanisms or perhaps only one. However, if so, this factor does not explain as much of the variance as expected. Situational or test-dependent factors play a greater role in the variance. This is interpreted as an indication of insufficiency in the theoretical structure, or in conventional test designs.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D005163:Factor Analysis, Statistical; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009433:Neural Inhibition; D009949:Orientation / Q000502:physiology; D051381:Rats; D012193:Reversal Learning / Q000502:physiology; D012686:Septal Nuclei / Q000502:physiology; D012688:Septum Pellucidum / Q000502:physiology*; D013028:Space Perception / Q000502:physiology