Effects of diets and cold acclimation on lipoprotein lipase activity and cyclic nucleotide levels in some tissues of rats.
In view to study a possible regulation of lipoprotein lipase (LPL) activity by tissue cyclic nucleotide levels (cAMP and cGMP), parallel determinations of the three factors were performed on brown adipose tissue (BAT), epidymal fat (WAT) and heart of rats. Opposite variations of cAMP levels and LPL activity were only observed in WAT following high fat diet administration. The enhancement of LPL activity in BAT and in heart by cold acclimation or feeding an hyperlipidic diet was never associated with a decrease in cAMP content. The variations of cAMP and cGMP levels were not dependent. It is concluded that there is no effect of cyclic nucleotide levels in the enhancement of LPL activity in these tissues.
D000064:Acclimatization; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D003080:Cold Temperature; D004041:Dietary Fats / Q000494:pharmacology*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D051381:Rats
D004041:Dietary Fats; D009712:Nucleotides, Cyclic; D008071:Lipoprotein Lipase