title: Natural resistance to methotrexate in human acute nonlymphocytic leukemia.
mesh_terms: D000328:Adult; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003857:Deoxyuridine / Q000378:metabolism; D004351:Drug Resistance; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008727:Methotrexate / Q000097:blood / Q000494:pharmacology*; D008875:Middle Aged; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D013762:Tetrahydrofolate Dehydrogenase; D003857:Deoxyuridine; D008727:Methotrexate