Transfer of iron from Ferastral and other organic complexes to transferrin as measured by reticulocyte uptake.
The transfer of iron from the iron carbohydrate complexes, Ferastral, Imferon, and Jectofer, and from ferric chloride has been studied by the effect of such transfer in reducing reticulocyte uptake of 59Fe from labelled transferrin. There are plasma factors which augment the transfer of iron from complex to transferrin. The pattern of transfer from Ferastral and from Imferon are similar: at concentration of 5000 microgram/100 ml and 1250 microgram/100 ml in plasma these complexes transfer about 0.8% and 1.7%, respectively. Jectofer transfers about four times these amounts under similar conditions. In the case of Ferastral there is evidence of an equilibrium between transferrin-bound and Ferastral-bound iron. The characteristics of Ferastral assessed in this way suggest that it may prove suitable for therapeutic use as a total dose infusion.
D002478:Cells, Cultured; D004338:Drug Combinations; D005290:Ferric Compounds / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood; D007505:Iron-Dextran Complex / Q000378:metabolism; D012156:Reticulocytes / Q000378:metabolism*; D013012:Sorbitol / Q000378:metabolism; D013223:Statistics as Topic; D013997:Time Factors; D014168:Transferrin / Q000032:analysis
D004338:Drug Combinations; D005290:Ferric Compounds; D014168:Transferrin; D013012:Sorbitol; D007505:Iron-Dextran Complex; D007501:Iron