[Cellular immunity indices in osteogenic sarcoma].
Prior to the treatment 39 patients with osteogenic sarcoma were examined for some cell immunity indices by the skin-allergic reaction of delayed hypersensitivity (RDH) and the reaction of suppression of leucocytes migration (RSLM). As an antigen a polysaccharide fraction of osteogenic sarcoma was employed, for the control--normal bone polysaccharide fraction. In 25 patients the course of the disease was followed up for 8--14 months after the primary examination. Both RDH and RSLM were found to show no essential difference in the reactions for polysaccharide antigens isolated from osteogenic sarcoma and normal bone. In patients with a rapid growth of the primary tumor negative RSLM was noted, while RDH indices failed to show such differences. In patients without any signs of the progressing disease during 8--14 months since the moment of the examination, as a rule, positive RSLM and RDH are noted. In patients with a precipitous course of the disease 1--8 months prior to the treatment negative RSLM and RDH are more frequently observed.
D000293:Adolescent; D000328:Adult; D000941:Antigens; D000951:Antigens, Neoplasm; D002464:Cell Migration Inhibition; D002648:Child; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005269:Femur / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D008297:Male; D012516:Osteosarcoma / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology; D012882:Skin Tests; D012995:Solubility; D013997:Time Factors
D000941:Antigens; D000951:Antigens, Neoplasm; D011134:Polysaccharides
Nekotorye pokazateli kletochnogo immuniteta u bol'nykh osteogennoĭ sarkomoĭ.