Comparison of antiplaque agents using an in vitro assay reflecting oral conditions.
An in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. Chlorhexidine was found to inhibit the formation of in vitro plaque by Actinomyces viscosus, A naeslundii, Streptococcus mutans and S sanguis. Actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.
D000190:Actinomyces / Q000166:cytology / Q000187:drug effects; D000268:Adhesiveness; D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001645:Biguanides / Q000494:pharmacology*; D002417:Cattle; D002710:Chlorhexidine / Q000378:metabolism / Q000494:pharmacology*; D003743:Dental Enamel / Q000378:metabolism; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D003804:Dentin / Q000378:metabolism; D009055:Mouth / Q000382:microbiology*; D013295:Streptococcus mutans / Q000166:cytology / Q000187:drug effects; D013298:Streptococcus sanguis / Q000166:cytology / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001645:Biguanides; D002710:Chlorhexidine