title: Prenylamine. Autoradiographic and neuropathological studies on myocardial mechanisms of action.
abstract: Myocardial localization of prenylamine (PNL), a well known antianginal drug, was studied by means of an autoradiographic technique to detect microscopical distribution of tritiated PNL (3H-PLN). Forty Wistar rats received 35 muCi/kg b. w. 3H-PNL i. p., the animals being killed 30 min after injection. Heart slices, 1 mm thick, were processed for both autoradiographic and conventional histological techniques.  3H-PNL was observed, mainly, as striae along sarcolemma; sarcolemmal/intramyocardial 3H-PNL distribution ratio was 6 : 1. Preferential membrane deposition of 3H-PNL is probably related to the calcium transport inhibiting action of the drug, previously described.
mesh_terms: D000818:Animals; D001345:Autoradiography; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D011299:Prenylamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011299:Prenylamine