Effects of bile salts on the motor activity of the guinea-pig gall-bladder in vitro.
Intra-luminal pressures were measured in in vitro preparations of the guinea-pig gall bladder. Intrinsic tone and spontaneous activity were recorded together with the response of the gall-bladder to Pancreozymin. The effect of the presence of a variety of conjugated and unconjugated bile salts in the luminal fluid [pH 7.4] was studied. Sodium deoxycholate and sodium chenodeoxycholate had in inhibitory effect on motor activity at concentrations as low as 6.0 times 10(-6) mol. 1(-1) Sodium taurocholate at a concentration of 3 times 10(-3) mol. 1(-1) promoted regular spontaneous activity. The results are discussed in relation to their possible physiological, pathological and pharmacological implications.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000494:pharmacology; D005704:Gallbladder / Q000502:physiology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000502:physiology; D011312:Pressure; D013657:Taurodeoxycholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D013657:Taurodeoxycholic Acid; D002766:Cholecystokinin