title: [Comparative clinical and histological studies on extraction wounds with and without local application of a salicylic acid preparation (Apernyl)].
abstract: Selected patients with extraction wounds served to experiment with Apernyl-styli of Bayer. Contralateral alveoli were used as controls. 10 days following operation biopsies were taken from treated and untreated alveoli. Histologically, a morphometric study was made, and clinically healing was judged by the frequency of complications and the initial physiologic pain. The results show that Apernyl does not influence histological healing, positively or negatively. Thus, the results obtained by Nordenram and Band (1970) and Satoh et al. (1973) could be confirmed. Clinically, there were significanlty less p.o. complications in patients with Apernyl prophylaxis; 2 of 51 treated alveoli compared to 8 of 45 untreated ones. Pain was significantly reduced: 17 of the 19 patients complained of pain in the untreated half of the jaw, while only 4 suffered pain on the treated side. This confirms the findings of Neuner and Panzera and Neuner and Schegg (1972 and 1969 resp.).
mesh_terms: D000539:Alveolar Process / Q000473:pathology; D001777:Blood Coagulation / Q000187:drug effects; D004341:Drug Evaluation; D004368:Dry Socket / Q000517:prevention & control; D006097:Granulation Tissue / Q000187:drug effects; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D012459:Salicylates / Q000627:therapeutic use*; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
chemical_list: D012459:Salicylates
vernacular_title: Vergleichende klinische und histologische Untersuchungen an Extraktionswunden mit und ohne lokale Applikation eines Salicylsäurepräparates (Apernyl)