Radiation-induced erythroleukemia in the beagle dog. A hematologic summary of five cases.
Eleven cases of myeloproliferative disease occurred in a group of 24 beagle dogs placed in a 60Co gamma-ray field at about 13 months of age and irradiated at an exposure rate of 5 R/22-hour day for duratior of life. Of these 11 dogs, 5 (described in this paper) were diagnosed as having erythroleukemia. The bone marrow showed marked erythroblastic hyperplasia, with maturation arrest of the erythroid elements, and increased numbers of myeloblasts and promyelocytes. The terminal peripheral blood was characterized by marked anemia and thrombocytopenia, with circulating erythrocytic precursors and abnormal erythrocyte morphology. Splenomegaly and hepatomegaly occurred in 4 of the 5 animals. In the spleens and livers of all 5, there was extensive leukemic infiltration and proliferation. The extent of leukemic involvement in other tissues and organs varied in individual dogs.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000209:etiology; D004285:Dogs; D004912:Erythrocytes / Q000473:pathology; D004913:Erythrocytes, Abnormal / Q000528:radiation effects; D005260:Female; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood* / Q000209:etiology; D008099:Liver / Q000473:pathology / Q000528:radiation effects; D008297:Male; D011830:Radiation Effects; D013154:Spleen / Q000473:pathology / Q000528:radiation effects
D003037:Cobalt Radioisotopes
Br J Haematol. 1960 Jan;6:26-33
14435454
J Am Vet Med Assoc. 1962 Oct 15;141:944-6
14012758
Blood. 1958 Dec;13(12):1176-84
13596420
Ann N Y Acad Sci. 1957 Oct 21;68(2):473-86
13488299
Blood. 1954 Apr;9(4):321-39
13149618
Blood. 1951 Apr;6(4):372-5
14820991
J Appl Physiol. 1950 Dec;3(6):365-77
14794596
Bibl Haematol. 1973;39:170-88
4521521
J Am Vet Med Assoc. 1968 May 15;152(10):1511-6
5239506
N Engl J Med. 1966 Jan 27;274(4):209-10
5216392
Cancer. 1965 Nov;18(11):1495-504
5215033