Polymorphonuclear function in acute myeloblastic leukemia.
A study of granulocyte functions in acute myeloblastic leukemia is reported. Functions were assessed by the ability of polymorphonuclear to migrate in Boyden's chamber, to ingest and kill staphylococcus aureus. Chemotaxis was grossly impaired. Cellular imparirment of phagocytosis and bactericidal capacity was observed in 5 and 9 patients. An inhibitor of phagocytosis and bactericidal capacity was observed in 9 and 4 patients. Results improved in complete remission.
D001770:Blood Bactericidal Activity; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007109:Immunity; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis