Reversible skeletal muscle damage after administration of local anesthetics with and without epinephrine.
Local anesthetic preparations with and without epinephrine, which are in common clinical use, produced reversible skeletal muscle damage in the rat after a single local administration. In addition, epinephrine alone, in concentrations of more than 1:200,000, caused similar but less extensive damage.
D000818:Animals; D004837:Epinephrine / Q000009:adverse effects*; D007273:Injections, Intramuscular / Q000009:adverse effects; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009336:Necrosis / Q000139:chemically induced; D011318:Prilocaine / Q000009:adverse effects*; D051381:Rats; D012038:Regeneration; D013997:Time Factors; D014313:Trismus / Q000209:etiology
D011318:Prilocaine; D008012:Lidocaine; D004837:Epinephrine