Fluoride content of dental plaque before, during and after ingestion of sucrose modified with fluoride or bicarbonate-phosphate.
Students ingested tablets daily during a period of 3 d growth of dental plaque and in connection with the collection of plaque specimens. The tablets varied in composition: sucrose (C), sucrose containing sodium bicarbonate-monopotassium orthophosphate and fluoride (BPF), and sucrose modified with fluoride (F). The daily fluoride dose in conjunction with the growth of plaque and the collection of specimens was 0.5 mg of total fluoride and 0.2 mg in the determination of ionized fluoride. The fluoride taken during the growth period did not significantly affect the total and ionized fluoride contents of the plaque. During the consumption of all the tablets, the total fluoride content of the plaque increased temporarily, after which a drop took place to close to the original value. In the case of the C- and the BPF-tablets, the increase was statistically significant (P-values less than 0.02 and less than 0.001, respectively). During the consumption of the BPF- and F-tablets, the ionized fluoride content dropped significantly (P-values less than 0.001 and less than 0.01, respectively). The investigation showed that a binding of the free fluoride ions in dental plaque takes place in connection with fermentation.
D000284:Administration, Oral; D000328:Adult; D001639:Bicarbonates / Q000008:administration & dosage*; D003773:Dental Plaque / Q000378:metabolism*; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008297:Male; D010710:Phosphates / Q000008:administration & dosage*; D011188:Potassium / Q000008:administration & dosage; D012964:Sodium / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage*
D001639:Bicarbonates; D010710:Phosphates; D013395:Sucrose; D012964:Sodium; D005459:Fluorides; D011188:Potassium