title: Thirteen cases of leukemia in a family.
abstract: Thirteen cases of leukemia, 12 of them acute, occurred in 3 generations of a family comprising 293 members. Individual cases could not be linked to the possession of any of a range of genetic markers. Cytogenetic studies showed no constitutional chromosome abnormalities. Preliminary results of virologic studies suggested the presence of oncornaviruses in at least 1 leukemic individual in this family. This aggregation of leukemia cases likely resulted from a genetic, probably polygenic, predisposition, in association with the activity of leukemogenic factors whose nature remains to be clearly defined.
mesh_terms: D000293:Adolescent; D000368:Aged; D001798:Blood Proteins; D002648:Child; D002675:Child, Preschool; D002875:Chromosomes; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007111:Immunity, Cellular; D007938:Leukemia / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D007951:Leukemia, Myeloid / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009858:Oncogenic Viruses / Q000302:isolation & purification; D010375:Pedigree
chemical_list: D001798:Blood Proteins; D006680:HLA Antigens