[Effect of serotonin on smooth muscle].
Serotonin caused contracion of the smooth muscles of the deferent duct and of the strip of rat stomach, acting upon the D-serotonin receptors. Only a small portion of its contractile effect (about 10--14%) was caused by the release of endogenous catecholamines. The action of serotonin on the strip of the rat stomach was accompanied by an increase of its entrance into the cells of Ca45 and Na22 isotopes. The concentration turn of the concentration-effect curve of serotonin on the stomach strip was connected with the accumulation of sodium ions in the cells.
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009121:Muscle Denervation; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D013270:Stomach; D014439:Tyramine / Q000494:pharmacology; D014649:Vas Deferens
D011985:Receptors, Serotonin; D012701:Serotonin; D008735:5-Methoxytryptamine; D012964:Sodium; D002118:Calcium; D009638:Norepinephrine; D014439:Tyramine; D010646:Phentolamine
O deĭstvii serotonina na gladkie myshtsy