Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy.
The occurrence of polymorphism in a series of 87 different loci coding for enzyme structure in human populations has been related to the size and the number of subunits in the corresponding enzymes. Polymorphic and nonpolymorphic enzymes did not differ on average in subunit size. However, multimeric enzymes showed a significantly lower incidence of polymorphism than didmonomeric enzymes. A particularly low incidence of polymorphism was noted among multimeric enzymes in which interlocus molecular hybrids occur. The findings are discussed in terms of the "neutralist" and "selectionist" hypotheses of polymorphism.
D004798:Enzymes; D005060:Europe / Q000208:ethnology; D006579:Heterozygote; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D044465:White People
D004798:Enzymes; D046911:Macromolecular Substances
Genetics. 1964 Apr;49:725-38
14156929
Genetics. 1976 Nov;84(3):609-29
1001881
Nat New Biol. 1973 Feb 21;241(112):229-33
4266990
Proc Natl Acad Sci U S A. 1968 Oct;61(2):582-5
5245992
Science. 1974 Apr 5;184(4132):28-37
4360954
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2848-52
4527913
Genet Res. 1973 Oct;22(2):201-4
4777279
Ann Hum Genet. 1972 Jul;36(1):9-20
4656772
Nature. 1971 Feb 12;229(5285):467-9
4925204
Ann Hum Genet. 1976 May;39(4):383-411
782337
Nature. 1976 JUL 15;262(5565):227-9
934341