Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells.
We have produced somatic cell hybrids between mouse myeloma cells and spleen cells derived from a BALB/c mouse immunized with purified influenza virus. The hybrid cells were found to produce large amounts of antibodies specific for the hemagglutinin of the virus and were able to induce tumor formation when injected into BALB/c mice.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis*; D000918:Antibody Specificity; D006389:Hemagglutinins, Viral; D006822:Hybrid Cells / Q000276:immunology*; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G / Q000096:biosynthesis; D009980:Influenza A virus / Q000276:immunology*; D007621:Karyotyping; D051379:Mice; D009194:Myeloma Proteins / Q000096:biosynthesis; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000276:immunology
D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D009194:Myeloma Proteins
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