Assignment of genes to regions of mouse chromosomes.
A genetic mapping procedure, called the duplication-deficiency method, is described. This method permits the genetic location of a translocation to be determined within a linkage group without the use of recombination. By utilizing the duplication-deficiency method to define the genetic breakpoints for a series of translocations involving a given chromosome and integrating this information with their cytological breakpoints, obtained by Giemsa banding, a genetic map of the chromosomes is constructed whereby groups of loci are assigned to banded regions. Duplication-deficiency mapping and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)145H translocations together with information from the c25H deletion have permitted mouse chromosome 7 to be divided into six and chromosome 19 into two definable genetic regions.
D000818:Animals; D001399:Azure Stains; D002874:Chromosome Mapping / Q000379:methods*; D008040:Genetic Linkage; D051379:Mice; D014178:Translocation, Genetic
D001399:Azure Stains
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