title: The hippocampus and stress induced 17-OHCS elevations.
abstract: The physiologic contribution of the limbic brain to emotionally induced stress is still poorly understood. The present study is designed to more specifically evaluate the role of the hippocampus in stress induced plasma 17-OHCS elevations. The conditional reflex to a sequential presentation of tone and shock was used as the stress agent in adult mongrel dogs. Plasma 17-OHCS levels were determined by the Porter-Silber method. Control and stress levels of 17-OHCS were determined before and after unilateral (left) hippocampectomy, and subsequent contralateral (right) hippocampectomy. A unilateral posterior hippocampal lesion partially attenuated (20%) the normal 17-OHCS stress response. In contrast to unilateral lesions, equivalent bilateral posterior hippocampal lesions abolished the normal 17-OHCS stress response. These observations support the thesis that the elevated 17-OHCS levels in response to the conditioning paradigm is dependent on the hippocampus. Furthermore, it is dependent upon the continuity of the hippocampal circuit and not upon the volumetric steroid binding capacity of the hippocampus. These studies also suggest that a unilaterally functioning hippocampus may be adequate to meet the physiologic needs of stress, as reflected by the 17-OHCS response.
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000818:Animals; D004285:Dogs; D006624:Hippocampus / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*
chemical_list: D015062:11-Hydroxycorticosteroids
references.citation: J Neurophysiol. 1953 May;16(3):324-40
references.pmid: 13053249
references.citation: Endocrinology. 1961 Dec;69:1080-4
references.pmid: 13913951
references.citation: J Neurophysiol. 1961 Jul;24:391-400
references.pmid: 13693311
references.citation: Neuroendocrinology. 1976;20(1):68-78
references.pmid: 934426
references.citation: Neuroendocrinology. 1975;18(2):154-60
references.pmid: 1172607
references.citation: Pharmacol Rev. 1962 Sep;14:317-445
references.pmid: 14017298
references.citation: Isr J Med Sci. 1975 May;11(5):493-5
references.pmid: 808515
references.citation: Neuroendocrinology. 1976;22(1):1-7
references.pmid: 1025483
references.citation: Neuroendocrinology. 1975;18(4):359-65
references.pmid: 175313
references.citation: Neuroendocrinology. 1971;7(1):11-5
references.pmid: 5543244
references.citation: Acta Physiol Acad Sci Hung. 1968;34(1):1-8
references.pmid: 4303088
references.citation: Horm Res. 1976;7(1):56-60
references.pmid: 1002117
references.citation: Acta Physiol Acad Sci Hung. 1961;20:293-7
references.pmid: 13892267
references.citation: Neuroendocrinology. 1978;25(5):303-9
references.pmid: 565880
references.citation: Science. 1966 Aug 12;153(3737):767-8
references.pmid: 5940897
references.citation: Surg Forum. 1960;11:383-5
references.pmid: 13683516
references.citation: Exp Brain Res. 1966;1(2):184-94
references.pmid: 4287424
references.citation: Am J Physiol. 1959 Jan;196(1):44-8
references.pmid: 13617434
references.citation: Brain. 1966 Mar;89(1):83-108
references.pmid: 5910903
references.citation: Physiol Behav. 1971 Nov;7(5):727-32
references.pmid: 5164364
references.citation: Neuroendocrinology. 1968;3(6):337-48
references.pmid: 4304308
references.citation: Can J Physiol Pharmacol. 1972 Apr;50(4):364-7
references.pmid: 4556776
references.citation: Acta Endocrinol (Copenh). 1975 Dec;80(4):625-9
references.pmid: 1242575
references.citation: Behav Biol. 1976 Apr;16(4):515-20
references.pmid: 986810
references.citation: J Neurochem. 1972 Dec;19(12):2737-45
references.pmid: 4652626
references.citation: Am J Physiol. 1961 Aug;201:337-40
references.pmid: 13755975
references.citation: Neuroendocrinology. 1973-1974;13(1):29-40
references.pmid: 4779046
references.citation: Neuroendocrinology. 1973;11(3):191-6
references.pmid: 4349362
references.citation: Neuroendocrinology. 1968;3(6):349-54
references.pmid: 4304309
references.citation: Surg Forum. 1957;8:546-9
references.pmid: 13529678
references.citation: Physiol Behav. 1977 Jun;18(6):1075-83
references.pmid: 928530