title: Zinc-binding ligands in milk and intestine: a role in neonatal nutrition?
abstract: The hypothesis that a zinc-binding ligand (ZBL) recently discovered in human milk but absent from cow's milk might be related to zinc nutrition in the neonate was investigated. The zinc-binding characteristics of rat milk were examined to determine if the rat was a suitable model. By gel filtration, rat milk was found to contain a ZBL with characteristics similar to those of the ZBL found in human milk. A similar ZBL was identified in the intestinal mucosa of rats 16 days of age and older but was absent in rats from birth to 16 days. These results support the hypothesis that the ZBL of maternal milk may enhance zinc transport in the neonatal period before the development of intestinal mechanisms for zinc absorption.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000254:growth & development / Q000378:metabolism*; D007774:Lactation / Q000187:drug effects; D008892:Milk / Q000378:metabolism*; D008894:Milk Proteins / Q000302:isolation & purification / Q000378:metabolism*; D009747:Nutritional Physiological Phenomena; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D015032:Zinc / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D008894:Milk Proteins; D010121:Oxytocin; D015032:Zinc
references.citation: J Am Med Assoc. 1953 Jun 6;152(6):509-12
references.pmid: 13044560
references.citation: Lancet. 1977 Jan 22;1(8004):195
references.pmid: 64724
references.citation: Science. 1977 Feb 25;195(4280):789-90
references.pmid: 836589
references.citation: Lancet. 1973 Mar 24;1(7804):676-7
references.pmid: 4121892
references.citation: Lancet. 1971 May 29;1(7709):1091-4
references.pmid: 4102622
references.citation: Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1098-100
references.pmid: 4162235
references.citation: Acta Paediatr Scand. 1972 Sep;61(5):587-90
references.pmid: 4559695
references.citation: Pediatr Res. 1972 Dec;6(12):868-74
references.pmid: 4509185
references.citation: J Nutr. 1974 Jul;104(7):828-42
references.pmid: 4834342
references.citation: Proc Soc Exp Biol Med. 1973 Dec;144(3):793-5
references.pmid: 4765958
references.citation: Pediatrics. 1975 May;55(5):738-41
references.pmid: 1093110
references.citation: N Engl J Med. 1975 Apr 24;292(17):879-82
references.pmid: 1090826
references.citation: Proc Soc Exp Biol Med. 1971 Jan;136(1):294-7
references.pmid: 5540626