title: Use of sequential analysis in clinical trials of caries prophylactic agents.
abstract: Using a sequential t test, the objectives of two 3-year experimental clinical trials were achieved more efficiently by using fewer subjects over a shorter time. The assumption of identical distributions of each batch of data analyzed was not apparent and further work to establish the robustness of sequential t tests is indicated. Identification of subjects with more consistent caries increments during the period of a trial would also help to satisfy this assumption.
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D004245:DMF Index; D005069:Evaluation Studies as Topic; D005459:Fluorides / Q000627:therapeutic use; D005460:Fluorides, Topical / Q000627:therapeutic use; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D009067:Mouthwashes; D005459:Fluorides