[Absorption and urinary elimination of pyrazinamid administered alone or in combination with isoniazid and rifampicin].
The aim of this work to study the PZA absorption in man its urinary excretion. The PZA was administered alone and in association with INH or/and Rifampicin. The PZA dosage in blood and urine and pyrazinoic acid in urine were performed in a sample of 80 patients divided into 4 groups. PZA dosage was also performed in blood from mice in the same experimental conditions. Our results showed that in man, the titres in serum gave higher peaks when PZA was given alone. Titres were significantly lower when PZA was associated with the two other drugs. The comparative study of PZA seral rates in men and women in one side and mice in the other, showed that the seral concentration was proportional to the body weight. Urinary excretion of Pyrazinamide and pyrazinoic acid showed a relation between the seral concentration and the urinary concentration. However, there was no correlation between the maximum seral concentration and urinary excretion of pyrazinoic acid.
D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007538:Isoniazid / Q000627:therapeutic use*; D007700:Kinetics; D008297:Male; D051379:Mice; D011718:Pyrazinamide / Q000378:metabolism* / Q000627:therapeutic use / Q000652:urine; D012140:Respiratory Tract Diseases / Q000188:drug therapy; D012293:Rifampin / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin
Etude de l'absorption et de l'élimination urinaire du pyrazinamide administré seul ou en assoication avec l'isoniazide et la rifampicine.