Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia.
We have previously reported on two patients with acute promyelocytic leukemia (APL) who had what appeared to be a deletion of chromosome No. 17. We now describe a third patient with APL. All three patients had a structural rearrangement involving No. 15 and No. 17. Our current interpretation of the chromosomal abnormality is that it is a reciprocal translocation, t (15;17) (q22; q21). Evidence that this is a consistent rearrangement associated with APL comes not only from our three patients, but also from two other published cases of APL, studied with banding, who also had an identical abnormality.
D000328:Adult; D002872:Chromosome Deletion; D002902:Chromosomes, Human, 16-18; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic