Lack of effect of excess glucocorticoid hormone on the rate of dentin deposition in rats.
A study was undertaken to determine the effect on the rate of deposition of dentin when high levels of adrenal glucocorticoid hormone are administered to rats. The results indicate that in the hypercorticoid rat, despite an increased eruption rate and a reduced width of incisor wall, no alteration occurs in the rate of dentin formation.
D000311:Adrenal Glands / Q000187:drug effects; D000308:Adrenocortical Hyperfunction / Q000139:chemically induced / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D003804:Dentin / Q000187:drug effects* / Q000378:metabolism; D003809:Dentin, Secondary / Q000139:chemically induced; D005260:Female; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D051381:Rats
D008775:Methylprednisolone