Acute leukaemia during azathioprine therapy.
Various tumours, in particular lymphomas, have been reported in association with azathioprine treatment, both after renal transplantation and in other conditions. A case is reported here of acute myeloid leukaemia associated with azathioprine therapy for rheumatoid arthritis, and this is now the third case reported in the world literature of leukaemia arising during azathioprine therapy for a non-malignant condition.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*
D001379:Azathioprine
Ann Rheum Dis. 1964 Nov;23:480-4
14229581
Br Med J. 1969 May 31;2(5656):535-9
4890207
Ann Intern Med. 1967 Mar;66(3):507-21
4959981
J Pediatr. 1968 Mar;72(3):409-14
4170638
Proc R Soc Med. 1968 Dec 12;61(12):1312-5
4177973
Lancet. 1970 Oct 3;2(7675):710-2
4195943
Clin Exp Immunol. 1968 May;3(4):305-12
4297669
Am J Med. 1974 Dec;57(6):885-8
4611208
Arthritis Rheum. 1974 Jan-Feb;17(1):92-4
4810666
Br Med J. 1970 Nov 14;4(5732):420-2
4921286
Proc R Soc Med. 1969 Apr;62(4):411-6
4897833