Distinctions between the two-state and sequential models for cooperative ligand binding.
The two-state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two-state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X-100 and sodium cholate.
D000109:Acetylcholine / Q000378:metabolism*; D000495:Allosteric Site; D000818:Animals; D004557:Electric Organ; D005399:Fishes; D007700:Kinetics; D008024:Ligands; D008954:Models, Biological; D011950:Receptors, Cholinergic / Q000378:metabolism*
D008024:Ligands; D011950:Receptors, Cholinergic; D000109:Acetylcholine
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