A new irrigating solution for intraocular surgery: TC Earle Solution.
Electrolyte solutions--Plasma-lyte, TC Medium 199, TC Medium 199 plus additional bicarbonate, TC Earle Solution, and glutathione bicarbonate Ringer Solution--were evaluated for effectiveness in maintaining corneal thickness and endothelial viability. The TC Earle Solution was shown to be the most effective commercially available solution; little difference was demonstrated between TC Earle Solution and the experimental GBR Solution. Glucose and bicarbonate were found to be essential ingredients in the efficacy of the TC Earle Solution.
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D004338:Drug Combinations / Q000494:pharmacology; D004727:Endothelium / Q000378:metabolism; D005942:Gluconates; D005950:Glucose Solution, Hypertonic; D005978:Glutathione / Q000494:pharmacology; D007552:Isotonic Solutions / Q000494:pharmacology; D015636:Magnesium Chloride; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D011189:Potassium Chloride; D011817:Rabbits; D019346:Sodium Acetate; D012965:Sodium Chloride
D001639:Bicarbonates; D004338:Drug Combinations; D005942:Gluconates; D005950:Glucose Solution, Hypertonic; D007552:Isotonic Solutions; D009883:Ophthalmic Solutions; C012499:Plasma-lyte 148; C013003:glutathione-bicarbonate-Ringer solution; D015636:Magnesium Chloride; D012965:Sodium Chloride; D019346:Sodium Acetate; D011189:Potassium Chloride; D005978:Glutathione