Theoretical study of protein--lipid interactions in bilayer membranes.
An analysis is given for the perturbation of the order and composition of lipid bilayers near an intrinsic membrane protein. Two cases are examined: the protein influences the lipid order (i.e., "fluidity"), and the protein associates with one component of a lipid mixture preferentially. The order perturbation is studied as a function of temperature and lateral pressure by using Landau--de Gennes theory and a variational procedure. It is concluded that, for a given lateral pressure, the greatest amount of boundary lipid is present at the lipid phase-transition temperature. A critical point for the phase transition occurs, near which the amount of boundary lipid increases dramatically. The composition perturbation is modeled in a binary lipid mixture by using a simple regular solution theory. The perturbation is found not to extent much beyond the directly bound layer of lipids unless the solution is near a critical mixing point.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008563:Membrane Lipids; D008565:Membrane Proteins; D008954:Models, Biological; D013696:Temperature; D013816:Thermodynamics; D014783:Viscosity
D008563:Membrane Lipids; D008565:Membrane Proteins
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5435-9
202955
Biochemistry. 1976 Sep 21;15(19):4145-51
183811
Anal Biochem. 1978 Jan;84(1):263-71
580167
Biochemistry. 1977 May 31;16(11):2313-9
861212
Biochim Biophys Acta. 1976 Nov 11;455(1):1-7
990322
Biochemistry. 1976 Oct 19;15(21):4575-80
974077
Biochim Biophys Acta. 1972 Jul 3;274(1):38-48
4114576
Biochim Biophys Acta. 1974 Oct 29;367(2):165-76
4371833
Biochem Biophys Res Commun. 1976 Jan 26;68(2):363-8
1252234
Ann N Y Acad Sci. 1973 Dec 31;222:561-73
4361869
Proc Natl Acad Sci U S A. 1973 Feb;70(2):480-4
4346892
Biochim Biophys Acta. 1973 Jun 22;311(2):141-52
4352245
Biochim Biophys Acta. 1975 Sep 2;401(3):509-29
241398
Nature. 1975 Jun 26;255(5511):684-7
124402
Proc Natl Acad Sci U S A. 1975 Oct;72(10):3993-7
1060080
Biochim Biophys Acta. 1975 Mar 25;382(3):265-75
1125235
Biochim Biophys Acta. 1968 Nov 5;163(3):301-13
5721894
Biochim Biophys Acta. 1968 Nov 5;163(3):290-300
5721893