title: Noncoincidence of histone and DNA synthesis in cleavage cycles of early development.
abstract: The times of histone and DNA synthesis do not coincide in early cleavage of the sea urchin embryo. In fact, the production of histones increases during the interval after DNA synthesis (G2). Enucleate merogones, parthenogenetically activated, synthesize histones encoded upon maternal histone messenger RNA. The pattern of protein synthesis changes following fertilization, in part, but not solely, due to the increasing synthesis of histones relative to other proteins. Regulation of histone synthesis and the loading of newly replicated DNA with histones must themselves undergo change at the time of transition from cleavage cycles to cycles more typical of somatic cells.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D006657:Histones / Q000096:biosynthesis* / Q000302:isolation & purification; D012617:Sea Urchins / Q000378:metabolism
chemical_list: D006657:Histones; D004247:DNA
references.citation: Dev Biol. 1977 May;57(1):136-49
references.pmid: 67977
references.citation: Cell. 1977 Feb;10(2):237-43
references.pmid: 189936
references.citation: Proc Natl Acad Sci U S A. 1977 Jan;74(1):173-7
references.pmid: 264672
references.citation: Cell Differ. 1977 Mar;5(5-6):283-91
references.pmid: 558056
references.citation: Cell Biol Int Rep. 1977 Jan;1(1):23-30
references.pmid: 565255
references.citation: Proc Natl Acad Sci U S A. 1976 Jun;73(6):1863-7
references.pmid: 778847
references.citation: Eur J Biochem. 1977 Jan;72(2):385-92
references.pmid: 837922
references.citation: Cell. 1976 Sep;9(1):171-8
references.pmid: 987854
references.citation: Cell. 1976 Oct;9(2):311-22
references.pmid: 987857
references.citation: Cell. 1975 Jan;4(1):59-67
references.pmid: 1116174
references.citation: Nature. 1975 Sep 18;257(5523):247-8
references.pmid: 1161028
references.citation: Dev Biol. 1975 Apr;43(2):254-63
references.pmid: 1168601
references.citation: Eur J Biochem. 1975 Aug 15;56(2):335-41
references.pmid: 1175627
references.citation: Dev Biol. 1976 Feb;48(2):327-35
references.pmid: 1254085
references.citation: Proc Natl Acad Sci U S A. 1967 Aug;58(2):681-8
references.pmid: 4168359
references.citation: J Mol Biol. 1974 Sep 15;88(2):263-85
references.pmid: 4476799
references.citation: Proc Natl Acad Sci U S A. 1973 Oct;70(10):2840-4
references.pmid: 4517937
references.citation: Proc Natl Acad Sci U S A. 1973 Sep;70(9):2614-8
references.pmid: 4582192
references.citation: Biochim Biophys Acta. 1973 Feb 4;294(1):481-96
references.pmid: 4705997
references.citation: Biochem Biophys Res Commun. 1973 Jul 17;53(2):515-22
references.pmid: 4736817
references.citation: J Mol Biol. 1973 Oct 5;79(4):681-96
references.pmid: 4796595
references.citation: Nature. 1974 Jan 4;247(5435):36-8
references.pmid: 4808938
references.citation: Dev Biol. 1974 Feb;36(2):286-98
references.pmid: 4814569
references.citation: Eur J Biochem. 1974 Jul 1;46(1):83-8
references.pmid: 4850204
references.citation: J Cell Biol. 1966 Oct;31(1):1-9
references.pmid: 4961668
references.citation: J Mol Biol. 1969 Jun 28;42(3):559-75
references.pmid: 4979625
references.citation: Arch Biochem Biophys. 1972 Feb;148(2):633-41
references.pmid: 5063077
references.citation: Proc Natl Acad Sci U S A. 1967 Nov;58(5):1977-83
references.pmid: 5237492
references.citation: J Mol Biol. 1969 Oct 28;45(2):337-51
references.pmid: 5367032
references.citation: Nature. 1970 Aug 15;227(5259):680-5
references.pmid: 5432063
references.citation: Dev Biol. 1970 Feb;21(1):125-46
references.pmid: 5445757
references.citation: J Mol Biol. 1971 Apr 28;57(2):355-8
references.pmid: 5579623
references.citation: Nature. 1968 Aug 24;219(5156):860-1
references.pmid: 5673350
references.citation: Science. 1969 May 23;164(3882):961-3
references.pmid: 5813983
references.citation: Biochim Biophys Acta. 1969 Aug 20;186(2):349-57
references.pmid: 5822837
references.citation: Dev Biol. 1965 Dec;12(3):520-42
references.pmid: 5894666
references.citation: Dev Biol. 1976 Sep;52(2):310-7
references.pmid: 12194440
references.citation: J Biophys Biochem Cytol. 1961 Feb;9:445-62
references.pmid: 13786522
references.citation: Exp Cell Res. 1959;Suppl 6:227-35
references.pmid: 13792619
references.citation: Exp Cell Res. 1964 Oct;36:53-61
references.pmid: 14222747
references.citation: Proc Natl Acad Sci U S A. 1967 Feb;57(2):409-16
references.pmid: 16591485