Effects of N,N-dimethyltryptamine on behavioural habituation in the rat.
The processes involved in habituation and the various ways drugs might affect habituation are discussed. Exploration was measured in a holehoard and N,N-Dimethyltryptamine (DMT, 4 mg/kg) profoundly reduced the level of exploration, precluding any conclusions about the rate of habituation with this dose. However, both 2 and 4 mg/kg doses prevented the 24-hr retention of habituation of exploration. DMT (2 and 4 mg/kg) did not reduce the initial distraction to a tone stimulus, but the rate of habituation and its 24-hr retention was impaired.
D000818:Animals; D001288:Attention / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D008297:Male; D004130:N,N-Dimethyltryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D014363:Tryptamines / Q000494:pharmacology*
D014363:Tryptamines; D004130:N,N-Dimethyltryptamine