A method for the in vitro toxicity testing of dental restorative materials.
An vitro method of toxicity testing of dental restorative materials is described in which their clinical usage is closely simulated. The test material was separated from the cells by either a synthetic filter or dentine slice. Toxic effects were quantiated by determining changes in enzyme activity by scanning and integrating microdensitometry.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D006224:Cricetinae; D003764:Dental Materials / Q000633:toxicity*; D003793:Dental Restoration, Permanent; D007668:Kidney; D008722:Methods; D013385:Succinate Dehydrogenase / Q000378:metabolism; D015036:Zinc Phosphate Cement / Q000633:toxicity*
D003764:Dental Materials; D015036:Zinc Phosphate Cement; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase