[Experimental study of Gougerot-Sjögren disease in mice. Initial results].
The mouse was selected to provide an experimental model for Sjögren's disease. A comparative study was made between the normal mouse (C 57 Bl 6) and the spontaneously auto-immune mouse (NZB) from an immunological and scintigraphic standpoint. The first immunological results involve study of the effects of sub-mandibulectomy on the thymus of the C 57 Bl 6 mouse. The are of little significance. First scintigraphic results show marked differences from the point of view of the uptake and excretion of Technetium 99 between normal old mice (17 months) (C 57 Bl 6) and those with spontaneous auto-immune behavior. Dynamic graphs of the uptake and excretion of Technetium 99 in the latter are closely similar to those found in mice after sub-mandibulectomy.
D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D011859:Radiography; D011877:Radionuclide Imaging; D012859:Sjogren's Syndrome / Q000276:immunology*; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013667:Technetium; D013950:Thymus Gland / Q000503:physiopathology*
D013667:Technetium
Etude expérimentale de la maladie de Gougerot-Sjögren chez la souris. Premières constatations.