[Extracorporeal treatment with L-asparaginase (author's transl)].
L-asparaginase therapy is often limited by allergy or toxicity and probably in some cases by antibody mediated inactivation of the enzyme. These problems can be avoided by extracorporeal application of l-asparaginase. As the enzyme is a stable tetramer with high molecular weight it cannot pass through the dialysis membrane in contrast to the amino acid l-asparagin which is destroyed. The resulting l-asparagin depletion of the plasma is  sufficient for therapeutic success. Effective extracorporeal l-asparaginase therapy is demonstrated in two patients with ALL who were resistant to other chemotherapy and could not be treated intravenously because of allergy and toxicity.
D000328:Adult; D000707:Anaphylaxis; D000906:Antibodies; D001215:Asparaginase / Q000009:adverse effects / Q000627:therapeutic use*; D004342:Drug Hypersensitivity; D005112:Extracorporeal Circulation; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D008970:Molecular Weight
D000906:Antibodies; D001215:Asparaginase
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Extrakorporale Asparaginasetherapie bei Allergie und toxischen Nebenwirkungen.