Evidence that pyrimidine dimers in DNA can give rise to tumors.
The Amazon molly, Poecilia formosa, is a small fish that grows in clones. Hence, cells from one animal may be transplanted to another without danger of rejection. Cells from thyroid and adjacent tissue were irradiated with UV light in vitro and injected into the abdominal cavity of isogeneic recipients. At appropriate UV doses and numbers of cells injected, all recipients showed exuberant thyroid proliferation. We give arguments and data indicating that the proliferation is a tumor, not a goitrogenic response. If the UV irradiation is followed, but not preceded, by photoreactivating illumination, the yield of thyroid growths is markedly decreased. Because other investigations have shown that photoreactivation monomerizes UV-induced cyclobutylpyrimidine dimers in DNA and does not affect other photoproducts, our data indicate that pyrimidine dimers in DNA can give rise to tumors.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005399:Fishes; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011740:Pyrimidine Dimers; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000473:pathology; D014466:Ultraviolet Rays
D011740:Pyrimidine Dimers
Science. 1950 Mar 3;111(2879):229
15410099
Radiat Res. 1961 Apr;14:394-403
13789181
J Natl Cancer Inst. 1955 Feb;15(4):1001-4
13233944
Cancer Res. 1977 Oct;37(10):3751-5
908017
Annu Rev Biophys Bioeng. 1972;1:293-346
4567755
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9
1061098
Proc Natl Acad Sci U S A. 1976 Mar;73(3):950-4
768988
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3363-6
4530308
Annu Rev Biochem. 1975;44:79-121
1094923
Photochem Photobiol. 1975 May;21(5):379-82
1108061
Nature. 1976 May 20;261(5557):195-200
775342
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1035-41
5264135