title: Protein synthesis in muscles from normal and dystrophic hamsters.
abstract: Homogenates of hindleg muscle were obtained from control and dystrophic male hamsters, 30 and 190 days of age, and were used to prepare the postmicrosomal pH5-supernatant fraction. The activity of this fraction in the incorporation of [14C]phenylalanyl-tRNA into peptides was increased in the dystrophic-muscle preparations. No such increase was found in brain or liver preparations from dystrophic hamsters. The increased capacity for aminoacyl-tRNA binding that was observed in preparations from dystrophic animals is discussed.
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000378:metabolism; D002474:Cell-Free System; D006224:Cricetinae; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D009124:Muscle Proteins / Q000096:biosynthesis*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D010441:Peptide Chain Elongation, Translational; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D051381:Rats
chemical_list: D009124:Muscle Proteins; D012346:RNA, Transfer, Amino Acyl
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