[Acceptance of amino acids by transfer RNA in the liver of rabbits in experimental diabetes complicated by glucocorticoid administration].
Alloxan diabetic rabbits were injected with hydrocortisone acetate (1 mg/kg) daily for one week. This led to a more pronounced decrease of acception of 14C-lysine, 14C-alanine, and 14C-leucine by tRNAs as compared to the diabetic status. Diminution of formation of aminoacyl-tRNA in the liver of diabetic animals was the result not only of insulin deficiency, but also of the negative action of glucocorticoids.
D000596:Amino Acids / Q000096:biosynthesis*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism*; D006854:Hydrocortisone / Q000009:adverse effects; D008099:Liver / Q000378:metabolism*; D008297:Male; D012343:RNA, Transfer / Q000378:metabolism*; D012346:RNA, Transfer, Amino Acyl / Q000172:deficiency*; D011817:Rabbits
D000596:Amino Acids; D012346:RNA, Transfer, Amino Acyl; D012343:RNA, Transfer; D006854:Hydrocortisone
Aktseptirovanie aminokislot transportnymi RNK v pecheni krolikov pri eksperimental'nom diabete, oslozhnennom vvedeniem gliukokortikoidov.