Phagocytosis of collagen by human gingival fibroblasts in vitro.
Human gingival fibroblasts cultivated on collagen-coated cover slips had collagen fibrils in deep folds of the cell membranes after one hour and fully interiorized fibrils by 24 hours. In 5-day sections, fibrils were within dense bodies, some containing multiple dense granules (40 to 50 nm) aligned along the surface of the interiorized collagen fibrils.
D002460:Cell Line; D003094:Collagen / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology* / Q000648:ultrastructure; D005881:Gingiva / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D010587:Phagocytosis
D003094:Collagen