Disseminated intravascular DNA thromboemboli. A complication of chemotherapy for acute lymphocytic leukemia.
Seven and one-half hours after receiving antileukemic therapy, an 11 year-old boy developed massive intravascular lysis of leukemic cells with subsequent pooling of DNA to form disseminated intravascular thromboemboli. The DNA thromboemboli produced neurologic symptoms and an alveolar capillary block with resultant dyspnea and death.
D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000097:blood*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood / Q000188:drug therapy*; D008297:Male; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
D004273:DNA, Neoplasm; D014750:Vincristine; D003520:Cyclophosphamide