Retinoblastoma and osteogenic sarcoma.
Radiogenic and non-radiogenic osteosarcomas are rather frequent in retinoblastoma patients and probably also in retinoblastoma families. Besides the pathologic gene for retinoblastoma, there must be a predisposition to develop osteogenic sarcomas, which is probably genetic.
D005134:Eye Neoplasms / Q000235:genetics*; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D009381:Neoplasms, Radiation-Induced; D009918:Orbital Neoplasms / Q000235:genetics; D012516:Osteosarcoma / Q000209:etiology / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics*