Accuracy of blood volume estimations in critically ill children using 125I-labelled albumin and 51Cr-labelled red cells.
Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes or more in 5 children, indicating the existence of slowly circulating red cells. Mixing of labelled albumin was complete within 10 minutes in 15 patients and within 20 minutes in all the children studied. In a burned patient with severe sepsis, exchange transfusion improved the clinical state and normalized the equilibration pattern of labelled red cells. The mean body/venous haematocrit ratio was 0.893+/-0.018 (SD) in the children with sepsis, 0.859+/-0.052 in the burned patients, and 0.916+/-0.078 in the children with acute lymphoblastic leukaemia, increasing with spleen size in the latter group.
D000293:Adolescent; D001811:Blood Volume Determination / Q000379:methods / Q000592:standards*; D002056:Burns / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes; D004912:Erythrocytes; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000097:blood; D008297:Male; D018805:Sepsis / Q000097:blood; D012711:Serum Albumin, Radio-Iodinated
D002860:Chromium Radioisotopes; D012711:Serum Albumin, Radio-Iodinated
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