Isoimmunization in haemophiliacs.
Serum samples from 134 Greek haemophiliacs multitransfused with fresh frozen plasma and factor--VIII or factor--IX concentrates were investigated for the presence of blood group antibodies. All samples were tested against a panel of selected cells of known but differing genotype. The incidence of blood group antibodies was 12.7%. Anti-D was found in 6 out of the 17 immunized patients, i.e., 35.3% of D-negative haemophiliacs were sensitized. It is concluded that the high incidence of immunization is a serious complication of repeated plasma transfusions.
D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity; D001787:Blood Group Incompatibility; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens; D008875:Middle Aged
D007518:Isoantibodies; D007519:Isoantigens