title: ["Prophylactic" intrathecal radiogold (198au) in leukaemia in children (author's transl)].
abstract: 198Au radiogold-colloid (Behring) was injected as "prophylactic" therapy against central nervous system leukaemia in 26 children with acute leukaemia (22 acute lymphatic and 4 myeloid). During the period of observation (1.3. 1972 to 1.9.1975), 23 children remained free of central nervous system recurrences: 16 children are alive 3 to 39 1/2 months later, seven died after 4 1/2 to 29 1/2 months from the underlying disease. In one child CNS leukaemia developed after about five months, in another one during a second haematological recurrence, while the third one developed retrobulbar infiltration in the optic nerve. In general, 2 mCi 198Au gold-colloid was injected intrathecally via a lumbar puncture. The method was well tolerated.
mesh_terms: D002648:Child; D004569:Electroencephalography; D006048:Gold Colloid, Radioactive / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D007938:Leukemia / Q000150:complications / Q000532:radiotherapy*; D007945:Leukemia, Lymphoid / Q000532:radiotherapy; D015470:Leukemia, Myeloid, Acute / Q000532:radiotherapy; D008581:Meningitis / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D006048:Gold Colloid, Radioactive
vernacular_title: Meningosis- "Prophylaxe" mit Radiogold (198Au) bei der Leukämie im Kindesalter