Pulmonary toxicity recurring after a six week course of busulfan therapy and after subsequent therapy with uracil mustard.
A growing number of drugs, including a number of alkylating agents, have been implicated as the cause of pulmonary diseases. A patient with chronic myelogenous leukemia presented with typical cytology, biopsy, and roentgenologic findings of lung toxicity after only six weeks of therapy with busulfan. There was subsequent clearing. A similar roentgenologic change also occurred after administration of uracil mustard. This has not been reported previously.
D002066:Busulfan / Q000009:adverse effects*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008168:Lung / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D014499:Uracil Mustard / Q000009:adverse effects*
D002066:Busulfan; D014499:Uracil Mustard