Effects of cannabis resin on learning by repetition in the rat.
Studies were made of the effects of cannabis resin in differing doses on a type of learning by repetition, using the water-filled maze technique, and on the conditioned avoidance reflex in the rat. When administered at a dose corresponding to 0.5 mg of delta9-THC per kg, the resin led to improved learning in both the types of test employed; opposite effects were observed with the higher dose (corresponding to 5 mg of delta9-THC per kg). These effects are probably attributable to complex reciprocal action between the active constituents of the resin, particularly THC, and the metabolisms of the cerebral monoamines and c-AMP.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002188:Cannabis; D003213:Conditioning, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D012116:Resins, Plant / Q000494:pharmacology*; D013997:Time Factors
D012116:Resins, Plant; D013759:Dronabinol