Studies on the placental transfer in rats of 59Fe- and 14C-labelled iron-poly (sorbitol-gluconic acid) complex.
The placental transfer of an iron-poly (sorbitol-gluconic acid) complex, Ferastral, has been studied. By use of the 59Fe-, 14C-sorbitol, and 14C-gluconic acid labelled complexes it was shown that the passage of the iron moiety is related to foetal need and that only negligible amounts of 14C from either 14C-sorbitol or 14C-gluconic acid labelled iron complexes were found in the foetus. This implies that the intact complex does not pass the placental barrier.
D000818:Animals; D002250:Carbon Radioisotopes; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D005942:Gluconates / Q000378:metabolism*; D007501:Iron / Q000008:administration & dosage* / Q000378:metabolism; D007504:Iron Radioisotopes; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013012:Sorbitol / Q000378:metabolism*
D002250:Carbon Radioisotopes; D004338:Drug Combinations; D005942:Gluconates; D007504:Iron Radioisotopes; D013012:Sorbitol; D007501:Iron