A clinical study of Osteomyelitis and septic arthritis.
Sixty-nine cases of Osteomyelitis, and 27 of septic arthritis have been presented. 69/96 (71%) were children below 12. The sites frequently involved were tibia, femur and humerus. Septic arthritis commonly involved the knee. The commonest organism was Penicillin - resistant Staphylococcus aureus. Though we sought but failed to establish that overt clinical malnutrition was aetiologically important, since 54% were well-fed children, the virulence of the sepsis in which an entire bone shaft may die is disturbing but unexplained. Whereas arthrotomy plus antibiotics gave uniformly good results for septic arthritis, in osteomyelitis, no single treatment regime was outstanding. We would recommend the tetracyclines, (eg. "Reverin"), in addition to appropriate surgery, as a routine.
D000293:Adolescent; D000328:Adult; D001170:Arthritis, Infectious / Q000453:epidemiology* / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000453:epidemiology* / Q000628:therapy; D013754:Tetracyclines / Q000627:therapeutic use
D013754:Tetracyclines