Drug-nucleic acid interactions: conformational flexibility at the intercalation site.
The conformational features of the intercalation site in polynucleotides were examined. We found that, for all the crystal structures of drug-dinucleoside complexes studied thus far, two torsion angles differ from those found in A RNA (phi and chi) and that alternate sugar puckering is not a prerequisite for intercalation. This intercalation geometry, which is the basis of helix axis displacement in a polymer, would necessitate conformational changes in the adjacent nucleotides. The base-turn angle is less sensitive to the conformation of the backbone than it is to small alterations in the base-pairing geometry. We postulate that this angle is dependent on the nature of the intercalating drug.
D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations
D009696:Nucleic Acids; D004364:Pharmaceutical Preparations
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