title: Evidence that pyrimidine dimers in DNA can give rise to tumors.
abstract: The Amazon molly, Poecilia formosa, is a small fish that grows in clones. Hence, cells from one animal may be transplanted to another without danger of rejection. Cells from thyroid and adjacent tissue were irradiated with UV light in vitro and injected into the abdominal cavity of isogeneic recipients. At appropriate UV doses and numbers of cells injected, all recipients showed exuberant thyroid proliferation. We give arguments and data indicating that the proliferation is a tumor, not a goitrogenic response. If the UV irradiation is followed, but not preceded, by photoreactivating illumination, the yield of thyroid growths is markedly decreased. Because other investigations have shown that photoreactivation monomerizes UV-induced cyclobutylpyrimidine dimers in DNA and does not affect other photoproducts, our data indicate that pyrimidine dimers in DNA can give rise to tumors.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005399:Fishes; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011740:Pyrimidine Dimers; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000473:pathology; D014466:Ultraviolet Rays
chemical_list: D011740:Pyrimidine Dimers
references.citation: Science. 1950 Mar 3;111(2879):229
references.pmid: 15410099
references.citation: Radiat Res. 1961 Apr;14:394-403
references.pmid: 13789181
references.citation: J Natl Cancer Inst. 1955 Feb;15(4):1001-4
references.pmid: 13233944
references.citation: Cancer Res. 1977 Oct;37(10):3751-5
references.pmid: 908017
references.citation: Annu Rev Biophys Bioeng. 1972;1:293-346
references.pmid: 4567755
references.citation: Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9
references.pmid: 1061098
references.citation: Proc Natl Acad Sci U S A. 1976 Mar;73(3):950-4
references.pmid: 768988
references.citation: Proc Natl Acad Sci U S A. 1974 Sep;71(9):3363-6
references.pmid: 4530308
references.citation: Annu Rev Biochem. 1975;44:79-121
references.pmid: 1094923
references.citation: Photochem Photobiol. 1975 May;21(5):379-82
references.pmid: 1108061
references.citation: Nature. 1976 May 20;261(5557):195-200
references.pmid: 775342
references.citation: Proc Natl Acad Sci U S A. 1969 Nov;64(3):1035-41
references.pmid: 5264135