The effect of kallikrein on central effects of acetylcholine in rats receiving indomethacin and prostaglandin E1.
Kallikrein given in combination with acetylcholine (ACh) increased the central inhibitory action of ACh as measured in the Lat's test, duration of thiopental sleep and inhibition of electrogenic convulsions. Indomethacin aboished the potentiating effect of kallikrein on these actions of ACh, PGE1 did not play a significant role in the influence of kallikrein on the central action of ACh. However, inhibition of prostaglandin synthesis with indomethacin plays an important role in the interaction of kallilkrein and ACh.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D004357:Drug Synergism; D007213:Indomethacin / Q000494:pharmacology*; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
D011453:Prostaglandins; D011458:Prostaglandins E; D010095:Oxotremorine; D007610:Kallikreins; D013874:Thiopental; D000109:Acetylcholine; D001920:Bradykinin; D007213:Indomethacin