[Clinical significance of cytochemical findings of childhood acute lymphoblastic leukaemia (author's transl)].
The initial bone marrow smeasrs of 821 children with ALL have been cytochemically analysed. (PAS-, acid phosphatase-(SPH), peroxydase-(POX), alpha-N-esterase-(EST)reaction) with regard to presenting clinical data and course of disease. Granular reactions of PAS and SPH were not meaningful in this respect. The paranuclear SPH-reaction was associated with high incidence of mediastinal mass, high peripheral blas count and male preponderance. All 5 patients with histories of more than 12 weeks duration belongs to the PAS-type of ALL (cloddy reaction). The PAS-type showed a higher incidence of CNS-leukaemia and generally a less favorable prognosis as compared to the UND-type. Thereby a high proportion of PAS positive cells, independently of other risk factors, indicates a better prognosis. The highterto neglected weak EST-reaction (Grad I and II according to Löffler) seems to signalise a clincally distinct subtype of ALL with a younger age distribution maximum as compared to the UND-type, low incidence of risk factors, high rate of remissions lasting more than 2 years but unfavorable endprognosis.
D000135:Acid Phosphatase / Q000378:metabolism; D000367:Age Factors; D010131:Aminosalicylic Acid; D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D002490:Central Nervous System; D002648:Child; D002675:Child, Preschool; D004950:Esterases / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications; D010544:Peroxidases / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
D010131:Aminosalicylic Acid; D010544:Peroxidases; D004950:Esterases; D000135:Acid Phosphatase
Klinische Bedeutung cytochemischer Befunde bei akuten lymphoblastischen Leukämien im Kindesalter