Studies of bone and soft-tissue tumours induced in rats with radioactive cerium chloride.
A colloidal suspension of radioactive cerium chloride was inoculated into the hind legs of Sprague Dawley rats. Bone and soft-tissue tumours were induced at the site of inoculation in 77% of the animals. All bone tumours were osteogenic osteosarcomas. Soft tissue tumours were mostly malignant and were of various histological types, predominantly fibrosarcomas, haemangiopericytomas, angiosarcomas and rhabdomyosarcomas. A kinetic study showed that the doubling time (DT) of tumours was closely correlated with the anatomical site of tumour development: bone tumours had a DT of 17.4 +/- 4.3 days and malignant tumours which developed in soft tissues had a DT ranging from 7.4 to 8.4 days with the exception of two haemangiosarcomas which had a long DT of 17 +/- 0.6 days. Pulmonary metastases were frequent for osteosarcomas and tumours of vascular origin. This model of induction of bone and soft-tissue tumours in rats by injection of a colloidal suspension of radioactive cerium chloride offers the possibility of more comprehensive physiopathological and kinetic studies of these tumours and may constitute a good model for their human counterparts.
D000818:Animals; D001345:Autoradiography; D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology; D002565:Cerium Radioisotopes; D005354:Fibrosarcoma / Q000473:pathology; D006393:Hemangiopericytoma / Q000473:pathology; D006394:Hemangiosarcoma / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced; D012516:Osteosarcoma / Q000473:pathology; D051381:Rats; D012208:Rhabdomyosarcoma / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000209:etiology* / Q000473:pathology
D002565:Cerium Radioisotopes