The early detection of remission in acute myelogenous leukaemia by in vitro cultures.
Twenty-eight cases of acute myeloid leukaemia without normal myeloid colony growth in vitro were serially cultured by an in vitro agar culture method during remission induction therapy. Colony formation frequently returned before morphological evidence of remission. Without early return of colony formation drug induced aplasia was prolonged and fatal. Analysis of the pattern of return of in vitro colony forming cells may be of value in designing the chemotherapy schedule.
D001854:Bone Marrow Cells; D002455:Cell Division; D002478:Cells, Cultured; D002999:Clone Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D012075:Remission, Spontaneous; D013997:Time Factors