title: A method for the in vitro toxicity testing of dental restorative materials.
abstract: An vitro method of toxicity testing of dental restorative materials is described in which their clinical usage is closely simulated. The test material was separated from the cells by either a synthetic filter or dentine slice. Toxic effects were quantiated by determining changes in enzyme activity by scanning and integrating microdensitometry.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D006224:Cricetinae; D003764:Dental Materials / Q000633:toxicity*; D003793:Dental Restoration, Permanent; D007668:Kidney; D008722:Methods; D013385:Succinate Dehydrogenase / Q000378:metabolism; D015036:Zinc Phosphate Cement / Q000633:toxicity*
chemical_list: D003764:Dental Materials; D015036:Zinc Phosphate Cement; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase