title: Endocarditis due to strain of Cardiobacterium hominis resistant to erythromycin and vancomycin.
abstract: Endocarditis caused by Cardiobacterium hominis was observed in a penicillin-allergic patient with a prosthetic cardiac valve who had received prophylactic therapy with erythromycin for dental extractions. The organism was resistant to erythromycin and vancomycin, with minimal inhibitory concentrations of 12.5 microgram/ml and 25 microgram/ml, respectively, but was sensitive to penicillin G, tetracycline, cephalexin, and cefaclor. This case suggests that currently recommended antibiotic prophylactic therapy for endocarditis, especially in penicillin-allergic patients, may be inadequate for unusual pathogens such as C hominis.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D004917:Erythromycin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D010400:Penicillin G / Q000627:therapeutic use; D010403:Penicillin Resistance; D011292:Premedication; D014081:Tooth Extraction; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D004917:Erythromycin; D014640:Vancomycin; D010400:Penicillin G