Nephrotoxicity associated with combined gentamicin-amphotericin B therapy.
The administration of a low total dose of amphotericin B to four consecutive patients already receiving gentamicin resulted in a deterioration of renal function in all. No other cause of the renal dysfunction was apparent in three cases. It appears probable that these drugs exhibit synergistic nephrotoxicity.
D000368:Aged; D000666:Amphotericin B / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology*
D005839:Gentamicins; D000666:Amphotericin B