Endocrine function after antineoplastic therapy in 22 children with acute lymphoblastic leukaemia.
In 22 children who were in complete remission after acute lymphoblastic leukaemia endocrinological investigations were performed 5-12 weeks after cessation of therapy. The children had received central nervous system irradiation (tele-Co60, 850-1800 rad), and long term, aggressive cytostatic drug therapy during 21 to 36 months. Growth hormone, TSH, thyroxine, LH, FSH, cortisol secretion, and urinary concentrating capacity were found to be normal, with a few exceptions where borderline results were obtained.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004702:Endocrine Glands / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000532:radiotherapy; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*; D012075:Remission, Spontaneous; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism
D000970:Antineoplastic Agents; D006728:Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine; D006854:Hydrocortisone