title: Testicular disease in acute lymphoblastic leukaemia in childhood. Report on behalf of the Medical Research Council's Working Party on leukaemia in childhood.
abstract: In three trials conducted by the Medical Research Council on acute lymphoblastic leukaemia in childhood the incidence of testicular infiltration in relation to presenting features and treatment was analysed. Initial severe thrombocytopenia was associated with an increased incidence. Testicular infiltration was occasionally found during treatment in patients with high blood leucocyte counts at diagnosis but the main incidence in patients with all types of disease occurred within one year of stopping treatment. The incidence may be increased when "second-line" drugs, especially cyclophosphamide, have been used. A reappraisal of the value of additional drugs in maintenance treatment of patients with good prognosis is needed.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000532:radiotherapy; D007958:Leukocyte Count; D008297:Male; D009362:Neoplasm Metastasis; D011379:Prognosis; D012075:Remission, Spontaneous; D013736:Testicular Neoplasms; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D003520:Cyclophosphamide
references.citation: Blood. 1965 Aug;26:133-41
references.pmid: 14335085
references.citation: Biol Reprod. 1970 Dec;3(3):308-26
references.pmid: 4108372
references.citation: Cancer. 1969 Jun;23(6):1290-5
references.pmid: 5818886
references.citation: Lancet. 1972 Jun 3;1(7762):1212-4
references.pmid: 4113192
references.citation: Br Med J. 1972 Aug 5;3(5822):311-4
references.pmid: 4505467
references.citation: Cancer. 1975 Apr;35(4):1203-11
references.pmid: 1054286