title: Stochastic theory of ligand migration in biomolecules.
abstract: When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 10(3) bars (0.1 to 100 MPa) is treated.
mesh_terms: D001665:Binding Sites; D002248:Carbon Monoxide; D008024:Ligands; D008956:Models, Chemical; D009211:Myoglobin; D010782:Photolysis; D011485:Protein Binding; D011506:Proteins
chemical_list: D008024:Ligands; D009211:Myoglobin; D011506:Proteins; D002248:Carbon Monoxide
references.citation: Biochim Biophys Acta. 1977 Dec 23;462(3):718-30
references.pmid: 202310
references.citation: Biochemistry. 1975 Dec 2;14(24):5355-73
references.pmid: 1191643