title: [Serum methotrexate determination by microbiological assay in patients receiving high-dosage methotrexate (author's transl)].
abstract: Microbiological assay according to Burchenal (modified by Mehta) is used for the determination of the serum methotrexate (MTX) level. Fifty cycles of high-dose MTX therapy were monitored in 11 patients with osteogenic sarcoma. The results showed close correlation with the clinical course of the therapy. The serum level of MTX was elevated in patients with symptoms of toxicity.
mesh_terms: D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D012516:Osteosarcoma / Q000097:blood / Q000188:drug therapy; D011863:Radioimmunoassay
chemical_list: D008727:Methotrexate
vernacular_title: Zur Methotrexatbestimmung im Serum mit einem mikrobiologischen Test nach hochdosierter Methotrexatbehandlung.