Development of chronic myelocytic leukemia during the course of acute lymphocytic leukemia in an adult.
A 59-year-old patient is described who presented with acute lymphocytic leukemia. Complete remission was induced rapidly with vincristine and prednisone. Nine months later he acquired the clinical and hematological picture of a myeloproliferative disease, and bone marrow cytogenetic studies demonstrated the presence of the Philadelphia chromosome. Within 4 months he again developed overt acute lymphocytic leukemia and died. Several lines of evidence have recently indicated a relationship between myeloproliferative and lymphoproliferative disorders, particularly chronic myelocytic and acute lymphocytic leukemia. This patient's course is another example of that association.
D001853:Bone Marrow / Q000648:ultrastructure; D002877:Chromosomes, Human; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000175:diagnosis; D007951:Leukemia, Myeloid / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010503:Periodic Acid-Schiff Reaction