Beta-endorphin: stimulation of growth hormone release in vivo.
Two micrograms of beta-endorphin (beta-lipotropin61-91) injected intraventricularly in rats that had been treated with antiserum against somatostatin led to a 6- and 10-fold stimulation of the concentration of plasma growth hormone (somatotropin) measured 10 and 20 min after injection of the peptide, whereas 400 mug of methionine-enkephalin led to a 4- to 6-fold increase of levels of plasma growth hormone at 10 min with a rapid return to basal levels at later time intervals. At doses of 5 and 25 mug, beta-endorphin led to a 20- to 30-fold stimulation of levels of plasma growth hormone, the maximal effect being measured between 20 and 30 min after injection. These data suggest the possible role of the endogenous opiate-like peptides in the control of growth hormone secretion.
D000818:Animals; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D008083:beta-Lipotropin
D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D010455:Peptides; D013006:Growth Hormone; D008083:beta-Lipotropin
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