title: Comparative susceptibility of Haemophilus species to cefaclor, cefamandole, and five other cephalosporins and ampicillin, chloramphenicol, and tetracycline.
abstract: The minimal inhibitory concentration of cefaclor, cephalexin, cephradine, cefamandole, cephalothin, cephapirin, cefazolin, ampicillin, chloramphenicol, and tetracycline for inhibition of 198 freshly isolated clinical strains of Haemophilus species (23 H. influenzae type b, 157 H. influenzae non-type b, 14 H. parainfluenzae, and 4 H. aphrophilus) was determined simultaneously by a slightly modified WHO-ICS agar dilution method. Nine strains were resistant to ampicillin. There was no correlation between ampicillin resistance and minimal inhibitory concentration of other antibiotics. All strains were susceptible to chloramphenicol, and all except five were susceptible to tetracycline. Cefaclor was the most active oral cephalosporin, and cefamandole was the most active parenteral cephalosporin. Among the seven cephalosporins tested, cefamandole was the most effective compound. All but two strains were inhibited by cefamandole at 2 mug or less per ml.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D002435:Cefamandole / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D006190:Haemophilus / Q000187:drug effects*; D010403:Penicillin Resistance; D013045:Species Specificity; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D002511:Cephalosporins; D002435:Cefamandole; D002701:Chloramphenicol; D000667:Ampicillin; D013752:Tetracycline
references.citation: Lancet. 1976 Mar 27;1(7961):702
references.pmid: 73682
references.citation: Antimicrob Agents Chemother. 1978 Feb;13(2):342-3
references.pmid: 306221
references.citation: Antimicrob Agents Chemother. 1978 May;13(5):861-4
references.pmid: 307367
references.citation: J Infect Dis. 1978 Sep;138(3):421-4
references.pmid: 308974
references.citation: J Infect Dis. 1978 May;137 Suppl:S180-S189
references.pmid: 306403
references.citation: Am J Clin Pathol. 1977 Sep;68(3):351-4
references.pmid: 302642
references.citation: J Infect Dis. 1978 May;137 Suppl:S169-S179
references.pmid: 650000
references.citation: Antimicrob Agents Chemother. 1976 Nov;10(5):814-23
references.pmid: 1008540
references.citation: Pediatrics. 1975 Jan;55(1):6-8
references.pmid: 1078611
references.citation: Antimicrob Agents Chemother. 1975 Dec;8(6):737-41
references.pmid: 1044248