DNA damage in synchronized HeLa cells irradiated with ultraviolet.
The lethal effect of UV radiation of HeLa cells is least in mitosis and greatest in late G1-early S. Photochemical damage to HeLa DNA, as measured by thymine-containing dimer formation and by alkaline sucrose sedimentation, also increases from mitosis towards early S phase. Computer simulations of UV absorption by an idealized HeLa cell at different stages of the cell cycle indicate that changes in damage could be due solely to changes in chromatin geometry. But survival is not exclusively a function of damage.
D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D002499:Centrifugation, Density Gradient; D003201:Computers; D004260:DNA Repair; D006367:HeLa Cells / Q000528:radiation effects*; D006801:Humans; D008954:Models, Biological; D014466:Ultraviolet Rays
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