Spectral analysis of mouse EEG after the administration of N,N-dimethyltryptamine.
Mice were implanted with permanent cortical electrodes. The EEG was recorded during the sleep-wake cycle and after the administration of N,N-dimethyltryptamine (DMT). Based upon spectral analysis the EEG was classified into three categories: awake, slow-wave sleep (SWS), and rapid eye movement sleep (REM). The dominant frequencies were located below 2 Hz in the case of SWS and between 6 and 9 Hz for REM. When DMT was administered intraperitoneally at 20 or 40 mg/kg, a dose-dependent hypersynchrony at 2.5-4.5 Hz was always observed lasting for up to 60 min. Hypersynchronous activity in the same range was occasionally observed during awake. In this range DMT induced a different but unique frequency for each animal. This individual frequency was closely reproduced by repeated administrations of DMT to the same animal.
D000818:Animals; D003344:Cortical Synchronization; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D004130:N,N-Dimethyltryptamine / Q000494:pharmacology*; D012894:Sleep Stages / Q000187:drug effects; D014363:Tryptamines / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects
D014363:Tryptamines; D004130:N,N-Dimethyltryptamine