title: The undamped and damped series elastic components of a vascular smooth muscle.
abstract: Small arterial resistance vessels (internal diameter about 175 micrometer) have been mounted on a myograph that enabled their wall tension, T, and internal circumference, L, to be measured and controlled with a time resolution of about 4 ms. Maximally activated vessels were subjected to isometric releases (step changes in L) and isotonic releases (step changes in T) of varying extents and at two different temperatures (27 degree C and 37 degree C). The recovery from an isometric release was monotonic and did not include the two phases seen in skeletal muscles. The isotonic release response did, however, contain a velocity transient lasting about 150 ms: the velocity immediately after the release was about six times the steady shortening velocity. The form of both the isometric and isotonic release responses and their dependence on the extent of release can be explained in terms of a modified Hill model in which the "series elastic component" (SEC) is replaced by the series combination of an undamped-SED (that is, an undamped elastic element) and a damped-SEC (a Voigt element). Although the initial response to both types of release was independent of temperature, all stages of subsequent responses were temperature dependent, with Q10's in the range 1.5 - 2.0. The results suggest that the responses to isotonic and isometric releases may in part be due to active processes.
mesh_terms: D000818:Animals; D004548:Elasticity; D007700:Kinetics; D008433:Mathematics; D008638:Mesenteric Arteries / Q000502:physiology; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D051381:Rats; D013696:Temperature
references.citation: J Physiol. 1958 Oct 31;143(3):515-40
references.pmid: 13588571
references.citation: J Physiol. 1977 Jul;269(2):441-515
references.pmid: 302333
references.citation: J Physiol. 1977 Mar;266(1):13-42
references.pmid: 856995
references.citation: Nature. 1977 Feb 10;265(5594):553-6
references.pmid: 401956
references.citation: J Cell Sci. 1977 Apr;24:327-49
references.pmid: 561090
references.citation: Circ Res. 1978 Dec;43(6):854-64
references.pmid: 709747
references.citation: Blood Vessels. 1978;15(1-3):65-82
references.pmid: 630137
references.citation: Am J Physiol. 1978 Jan;234(1):C14-26
references.pmid: 623237
references.citation: Cell Tissue Res. 1977 Oct 26;184(2):195-212
references.pmid: 922869
references.citation: Am J Physiol. 1977 Aug;233(2):H248-55
references.pmid: 888968
references.citation: Circ Res. 1977 Jul;41(1):19-26
references.pmid: 862138
references.citation: Am J Physiol. 1976 Nov;231(5 Pt. 1):1337-42
references.pmid: 826173
references.citation: J Physiol. 1974 Mar;237(3):477-93
references.pmid: 4207658
references.citation: J Physiol. 1966 Jun;184(3):511-34
references.pmid: 5963731
references.citation: Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):223-9
references.pmid: 4144693
references.citation: Circ Res. 1974 Apr;34(4):461-6
references.pmid: 4826922
references.citation: Nature. 1971 Oct 22;233(5321):533-8
references.pmid: 4939977
references.citation: Nature. 1976 Apr 15;260(5552):617-9
references.pmid: 1264225
references.citation: Blood Vessels. 1976;13(1-2):1-23
references.pmid: 1247692
references.citation: J Mol Biol. 1975 Oct 15;98(1):17-29
references.pmid: 1195377
references.citation: Am J Physiol. 1971 Jun;220(6):1890-5
references.pmid: 5087840
references.citation: Nature. 1970 Mar 14;225(5237):1053-4
references.pmid: 5416474