title: Laryngeal keratosis and subsequent carcinoma.
abstract: The frequency with which carcinoma develops in laryngeal keratoses is a controversial subject. A study of 92 cases of laryngeal keratosis with a minimum of five years' follow-up resulted in identification of three patients (3.26%) who developed laryngeal carcinoma. A reviews of the literature reveals that, in series of keratoses defined by stringent pathologic criteria, subsequent laryngeal carcinoma develops in 3.33%-4.31%. These findings support a low but predictable frequency of conversion to malignancy in laryngeal keratosis. A grading system for keratosis is presented and discussed with reference to clinicopathologic correlation.
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007642:Keratosis / Q000150:complications* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D007830:Larynx / Q000473:pathology; D008297:Male; D011230:Precancerous Conditions