Effect of moderate hemorrhagic hypotension on cerebral metabolism during ventriculocisternal perfusion in the conscious dog.
Early changes in cerebral metabolism during hemorrhagic hypotension in conscious dogs have been studied with a chronic ventriculocisternal perfusion system. The mean arterial blood pressure was held above the lower limit of the cerebral autoregulatory curve. There was a rise of free fatty acids (FFA) in cerebrospinal fluid at 30 minutes after the onset of hemorrhage. The cerebral arteriovenous difference of oxygen (AVDO2), AVD-glucose, and AVD-pH increased significantly after 60 minutes of hemorrhage, while AVD-TCO2 (tissue culture oxygen) rose only slightly. These changes may reflect some of the metabolic alterations that occur in moderate hypotension.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002552:Cerebral Ventricles; D002946:Cisterna Magna; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006470:Hemorrhage / Q000378:metabolism*; D007022:Hypotension / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism; D010477:Perfusion; D012119:Respiration; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D010169:Palmitic Acids