Microviscosity modulation during the cell cycle of neuroblastoma cells.
Microviscosity (n) of the cell membrane lipid layer was determined in synchronized C1300 mouse neuroblastoma cells (clone Neuro-2A) by fluorescence polarization of 1,6-diphenystratum. The determined n value was maximal in mitosis, decreased markedly in the G1 phase, remained constant at a low level during the S phase, and increased again during the G2 phase. These findings imply a direct role of the cell membrane fluidity in regulation of the cell cycle.
D000818:Animals; D002453:Cell Cycle; D002462:Cell Membrane / Q000032:analysis; D002999:Clone Cells; D008563:Membrane Lipids; D051379:Mice; D008856:Microscopy, Fluorescence; D009447:Neuroblastoma / Q000032:analysis / Q000473:pathology; D013050:Spectrometry, Fluorescence; D013696:Temperature; D013997:Time Factors; D014783:Viscosity
D008563:Membrane Lipids
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