Effect of glucocorticosteroids on the release of prostaglandin-like substances in anaphylaxis.
During anaphylactic reactions there are released thromboxane A2 and/or prostaglandin-like substances from perfused guinea pig lungs and from incubated fragments of guinea pig mesentery. Prostaglandin-like substances appear also in mixed venous blood of anaesthetized cats following an intravenous injection of rabbit blood. These release reactions are reduced or abolished both by indomethacin and by hydrocortisone.
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D002415:Cats; D005938:Glucocorticoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000378:metabolism; D008643:Mesentery / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D013928:Thromboxane A2 / Q000378:metabolism
D005938:Glucocorticoids; D011453:Prostaglandins; D013928:Thromboxane A2; D006854:Hydrocortisone; D007213:Indomethacin