Pilocarpine administration by contact lens.
A previous investigation had indicated that pilocarpine delivered to the eye by means of a hydrophilic contact lens provided better control of the intraocular pressure over a longer period and with a smaller concentration of pilocarpine. To clarify the situation further, an animal experiment was undertaken with radioactive labelled pilocarpine. Three situations were compared: pilocarpine administered by a contact lens, by drops, and by subconjunctival injection. The results indicated that the contact lens gave a greater concentration of the pilocarpine in the iris and ciliary body than either the drops or the subconjunctival pilocarpine. A high concentration of pilocarpine was achieved in the conjunctiva with drop administration and was comparable to that of subconjunctival administration.
D000818:Animals; D002924:Ciliary Body / Q000032:analysis; D003228:Conjunctiva / Q000032:analysis; D003263:Contact Lenses, Hydrophilic; D007498:Iris / Q000032:analysis; D010862:Pilocarpine / Q000008:administration & dosage* / Q000032:analysis; D013552:Swine
D010862:Pilocarpine