Opiates, prolactin, and the dopamine receptor.
The administration of a dopamine antagonist, chlorpromazine, and two opiates, morphine and methadone, resulted in a significant rise in serum PRL within 90-150 min. Prior administration of dopamine receptor agonists (apomorphine, levodopa, aand bromocriptine) blocked this effect. In contrast, cyproheptadine, a serotonin antagonist, did not. We suggest that the opiates induce hyperprolactinemia in man via dopamine receptor blockade.
D001058:Apomorphine; D001971:Bromocriptine; D002746:Chlorpromazine / Q000627:therapeutic use*; D003533:Cyproheptadine; D006556:Heroin Dependence / Q000188:drug therapy; D006801:Humans; D007700:Kinetics; D007980:Levodopa; D008691:Methadone / Q000627:therapeutic use*; D009020:Morphine / Q000627:therapeutic use*; D011388:Prolactin / Q000097:blood*; D011954:Receptors, Dopamine / Q000378:metabolism*
D011954:Receptors, Dopamine; D003533:Cyproheptadine; D001971:Bromocriptine; D007980:Levodopa; D009020:Morphine; D011388:Prolactin; D001058:Apomorphine; D002746:Chlorpromazine; D008691:Methadone