Membrane particle aggregates in innervated and noninnervated cultures of Xenopus embryonic muscle cells.
Clusters of membrane particle aggregates were found in the cultures of Xenopus embryonic muscle cells. In innervated cultures, the aggregates were usually found in the vicinity of the nerve. In terms of particle density and morphology, they resembled the postsynaptic particle aggregates of adult skeletal muscle fibers, suggesting that they may be related to acetylcholine receptors. Similar particle aggregates were also found in noninnervated cultures. They may correspond to extrajunctional clusters of acetylcholine receptors or "hot spots."
D000818:Animals; D002478:Cells, Cultured; D005614:Freeze Fracturing; D008297:Male; D009132:Muscles / Q000196:embryology / Q000294:innervation*; D009469:Neuromuscular Junction / Q000648:ultrastructure*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D013570:Synaptic Membranes / Q000648:ultrastructure; D014981:Xenopus
D011950:Receptors, Cholinergic
J Physiol. 1977 Jul;268(3):757-73
69707
J Physiol. 1977 Jul;268(3):731-56
69706
Science. 1977 Apr 29;196(4289):540-2
850796
J Cell Biol. 1974 Nov;63(2 Pt 1):567-86
4138515
J Physiol. 1975 Sep;250(3):513-39
1080806
J Cell Biol. 1976 May;69(2):501-7
57117
J Cell Biol. 1976 Aug;70(2 pt 1):338-47
939781
J Neurocytol. 1974 Mar;3(1):109-31
4596345
Cold Spring Harb Symp Quant Biol. 1976;40:373-88
7383
Cell Tissue Res. 1974 Jun 24;149(4):437-55
4546545
Proc Natl Acad Sci U S A. 1973 Jan;70(1):270-4
4509661
Cold Spring Harb Symp Quant Biol. 1976;40:211-30
181196
J Cell Sci. 1974 Nov;16(2):473-9
4448829
Physiol Rev. 1975 Jan;55(1):1-61
162810
Dev Biol. 1973 Mar;31(1):147-62
4787184
Brain Res. 1972 Jun 22;41(2):457-63
5038337
Proc Natl Acad Sci U S A. 1976 May;73(5):1641-5
1064036
Science. 1976 Sep 3;193(4256):915-7
948754
Nature. 1976 JUL 15;262(5565):217-8
934337
J Membr Biol. 1975;20(1-2):31-49
1121027