Stimulation of bone formation and bone resorption by fluoride in thyroparathyroidectomized rats.
In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone formation rate, bone and matrix apposition rates, and osteoid maturation rate; and increased endosteal resorbing surface and medullary area. The above-described F effects on bone were observed in TPTX as well as sham-treated animals. The effect of F treatment to stimulate periosteal matrix apposition was enchanced by TPTX. These results indicate that bone changes seen in animals treated with large amounts of F are not due to increased parathyroid activity.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects* / Q000473:pathology; D001842:Bone and Bones / Q000033:anatomy & histology; D002113:Calcification, Physiologic; D002118:Calcium / Q000097:blood; D005459:Fluorides / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D010280:Parathyroid Glands / Q000187:drug effects / Q000502:physiology* / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood; D010521:Periosteum / Q000502:physiology; D051381:Rats; D013268:Stimulation, Chemical; D013961:Thyroid Gland / Q000502:physiology; D013965:Thyroidectomy
D010281:Parathyroid Hormone; D005459:Fluorides; D002118:Calcium