Trisomy of 1q in preleukaemia with progression to acute leukaemia.
Marrow cells from an untreated man with preleukaemia were found to have trisomy for the long arm of chromosome 1 which was translocated to the end of the long arm of number 11, i.e., 46,XY, -11,+t (1:11) (q11 or q12; q25). The same abnormality was found in metaphases from 8 individual granulocytic colonies. With development of acute myelomonocytic leukaemia, in addition to the basic chromosome abnormality, trisomy of chromosome 8 and an extra chromosome number 19 with partial deletion were found. Fibroblasts grown from marrow biopsy material showed a normal diploid complement, 46,XY.
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D011289:Preleukemia / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy