title: Pulpal responses to operative procedures in rats receiving systemic methotrexate.
abstract: The systemic administration of methotrexate in nonlethal doses impairs the ability of the laboratory rat to localize an inflammatory response to operative dental procedures that result in exposures within the pulpal tissue. The pulpal healing response within these animals is thus greatly compromised.
mesh_terms: D000818:Animals; D003737:Dental Cavity Preparation; D003782:Dental Pulp / Q000033:anatomy & histology / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D003789:Dental Pulp Exposure; D005260:Female; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D009336:Necrosis / Q000473:pathology; D009504:Neutrophils / Q000166:cytology; D009804:Odontoblasts / Q000166:cytology; D051381:Rats; D014945:Wound Healing / Q000187:drug effects
chemical_list: D008727:Methotrexate