Antiviral effect of N-phenylacetoaminomethylene-DL-p-nitrophenylalanine (A-101) on murine leukemia viruses.
N-Phenylacetoaminomethylene-DL-p-nitrophenylalanine (A-101), when administered ip to male DDY mice infected with Friend leukemia virus, significantly inhibited virus-induced splenomegaly, reduced viable virus titers in spleen and plasma, and significantly prolonged survival time. A-101 also inhibited multiplication of the Friend and Moloney viruses in tissue culture systems.
D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D005622:Friend murine leukemia virus / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008979:Moloney murine leukemia virus / Q000187:drug effects; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013163:Splenomegaly / Q000188:drug therapy; D014412:Tumor Virus Infections / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010649:Phenylalanine; C018777:N-phenylacetoaminomethylene-DL-p-nitrophenylalanine