Can the frequency of myocardial infarction be reduced during coronary artery operations.
A prospective experiment was carried out in 56 patients undergoing coronary artery revascularization to determine whether those having a glucose-insulin-potassium (GIK) perfusion during the procedure would have fewer myocardial infarctions (MI) compared with patients given a control perfusion of Normosol-R. Six patients (11%) developed an MI, defined as a 24-hour creatine phosphokinase MB isoenzyme value of 100 IU per liter or greater. Four (13%) had control perfusions and 2(8%) had GIK perfusion. One MI in a double-graft recipient who had GIK perfusion occurred because of a technical surgical error; therefore, the corrected MI rate was 13% in control patients compared with 4% for the GIK group. These data, as well as the more frequent spontaneous defibrillation in patients who had GIK perfusion, suggest that GIK was of benefit.
D001786:Blood Glucose / Q000378:metabolism; D001026:Coronary Artery Bypass; D003331:Coronary Vessels / Q000601:surgery*; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D009203:Myocardial Infarction / Q000517:prevention & control*; D010477:Perfusion; D011188:Potassium / Q000008:administration & dosage / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose; D011188:Potassium