Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis.
Levels of alkaline phosphatase were measured in the primary tumor of 26 patients with osteosarcoma. One of seven patients with a tissue alkaline phosphatase level less than 0.6 microM/min/mg developed pulmonary metastases. In contrast, 16 or 17 patients with a tissue alkaline phosphatase level greater than 0.6 microM/min/mg developed pulmonary metastases. It thus appears that tissue alkaline phosphatase levels of primary osteosarcomas are strongly correlated with prognosis (p less than .01).
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis*; D001859:Bone Neoplasms / Q000201:enzymology*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000201:enzymology* / Q000556:secondary; D011379:Prognosis
D000469:Alkaline Phosphatase