Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E.
The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000502:physiology*; D005246:Feedback; D006023:Glycoproteins / Q000502:physiology*; D006098:Granulocytes / Q000166:cytology*; D006410:Hematopoiesis; D006801:Humans; D007962:Leukocytes / Q000166:cytology*; D008264:Macrophages / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009000:Monocytes / Q000502:physiology*; D011458:Prostaglandins E / Q000502:physiology*
D003115:Colony-Stimulating Factors; D006023:Glycoproteins; D011458:Prostaglandins E