Systemic mastocytosis in a patient with polycythemia vera treated with radioactive phosphorus.
Systemic mastocytosis occurred as a fatal event in a patient with long-standing polycythemia vera. The patient had been treated over the course of 21 yr with radioactive phosphorus. Possible relationships between mastocytosis and polycythemia vera, and also between mastocytosis and treatment with ionizing radiation, are discussed. Histopathologic and electron microscopic findings are illustrated. Difficulties in establishing the diagnosis of mast cell disease in this setting are also described.
D001706:Biopsy; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D011087:Polycythemia Vera / Q000150:complications* / Q000532:radiotherapy; D011183:Postoperative Complications; D011565:Psoriasis / Q000209:etiology; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology; D014582:Urticaria Pigmentosa / Q000209:etiology*
D010761:Phosphorus Radioisotopes