[Effectiveness of hypoxic hypoxia as a means of protecting the body from ionizing radiation exposure with the use of sodium oxybutyrate and mexamine].
While exerting a pronounced antihypoxic action on the body of white mice under nypoxic hypoxia, a combination of sodium hydroxybutyrate and mexamine given in comparatively low doses (100 and 2.5 mg/kg, respectively) did not remove the radioprotective effect of hypoxic hypoxia. In hemic and histotoxic hypoxia the drugs did not exhibit any antihy-oxic action.
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents; D012978:Sodium Oxybate / Q000627:therapeutic use*
D006885:Hydroxybutyrates; D011837:Radiation-Protective Agents; D008735:5-Methoxytryptamine; D012978:Sodium Oxybate
Effektivnost' gipoksicheskoĭ gipoksii kak sposoba zashchity organizma ot vozdeĭstviia ioniziruiushcheĭ radiatsii v usloviiakh primeneniia oksibutirata natriia i meksamina.