Suppressive effect of cyclophosphamide on the T-cell system in chickens.
Neonatal administration of 16 mg of cyclophosphamide in inbred chickens resulted in a transient, but profound, deficiency in the in vitro proliferative response of spleen cells. Functional T-cell deficiency was accompanied by a marked morphological degeneration in the thymus and thymus-dependent areas in the spleen.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002060:Bursa of Fabricius / Q000187:drug effects; D002645:Chickens; D003520:Cyclophosphamide / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects
D003520:Cyclophosphamide