A combination of sensitizers with high LET radiations.
Preliminary measurements of OER for pion beams in combination with a concentration of Misonidazole (0.4 mM) that is realistic in radiotherapeutic application are reported. These results indicate that 0.4 mM of misonidazole is as effective in reducing OER for negative pions as for X-rays. The application of high LET radiations in combination with hypoxic cell sensitizers is discussed.
D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D004735:Energy Transfer; D009593:Nitroimidazoles / Q000494:pharmacology*; D010100:Oxygen; D011838:Radiation-Sensitizing Agents
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D010100:Oxygen