Palate morphology and fetal movements in mice after DPH.
Effects of DPH on fetal development were studied using a dose which produced 65% cleft palate in the CD-1 strain. Generalized developmental retardation and diminution of fetal muscular movements occurred at the early fetal stage. Intermediate stages of palate closure persisted to term, indicating interference with palatine shelf rotation.
D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D051379:Mice; D009068:Movement; D009132:Muscles / Q000187:drug effects* / Q000196:embryology / Q000294:innervation / Q000502:physiology; D010159:Palate / Q000187:drug effects* / Q000196:embryology / Q000502:physiology; D010672:Phenytoin / Q000009:adverse effects*; D012399:Rotation
D010672:Phenytoin