Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities.
Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell-mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
D000917:Antibody Formation; D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D014594:Uterine Neoplasms / Q000235:genetics* / Q000276:immunology