Platinum complexes as radiosensitizers of hypoxic mammalian cells.
Cis-dichlorodiammineplatinum (II), or cis-PDD,  has recently been shown to be a potent radiosensitizer of bacteria, particularly under conditions of acute hypoxia. This study extends this observation to include the radiosensitization of mammalian cell (V-79) by low concentrations of cis-PDD, cis-dichlorobis(aziridine) platinum (II), and the trans-isomer of PDD as measured from survival curve analysis. This radiosensitization was obtained at concentrations of 10 micrometer, 60 micrometer, and 100 micrometer for the cis-PDD, aziridine-platinum, and trans-isomer respectively. The corresponding drug toxicity survival levels were 8, 40 and 50%. Dose modification factors of around 1.3 to 1.4 were observed.
D001388:Aziridines / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010100:Oxygen; D011838:Radiation-Sensitizing Agents
D001388:Aziridines; D009944:Organoplatinum Compounds; D011838:Radiation-Sensitizing Agents; D002945:Cisplatin; D010100:Oxygen