Chronic granulocytic leukemia: long-term remission in a patient with familial sarcoidosis.
A patient is described who has chronic granulocytic leukemia (CGL) and familial sarcoidosis, and who has been in complete remission for six years after a single course of busulfan therapy. Her bone marrow Philadelphia chromosome persists and the leukocyte alkaline phosphatase activity remains subnormal. Leukocyte alkaline phosphatase levels in nine white patients with sarcoidosis were all found to be low. Bone marrow chromosomes from two patients with active sarcoidosis showed no Philadelphia chromosome, but one of them, and our patient with CGL, exhibited a pericentric inversion of chromosome 9.
D000469:Alkaline Phosphatase / Q000097:blood; D001853:Bone Marrow; D002066:Busulfan / Q000627:therapeutic use*; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D010375:Pedigree; D012507:Sarcoidosis / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic
D000469:Alkaline Phosphatase; D002066:Busulfan