Engraftment with chronic granulocytic leukemia cells in acute myeloid leukemia.
A deliberate engraftment with nonirradiated chronic granulocytic leukemia (CGL) cells was performed in a patient with acute myeloid leukemia (AML) at a time when he was resistant to cytotoxic drug chemotherapy, pancytopenic and developed an infection. The CGL engraftment was confirmed by the presence of a Ph1-positive donor clone in the recipient's bone marrow and by the pattern of colony growth of the recipient's bone-marrow cells cultured in vitro. Bone marrow engraftment in the host helped in the resolution of infection and permitted the administration of further cytotoxic drugs, as a result of which a remission of AML occurred.
D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002904:Chromosomes, Human, 21-22 and Y; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D014184:Transplantation, Homologous