ATYPICAL SURFACE MAKER CHARACTERISTICS IN A T-cell lymphoma.
A case of T-cell lymphoma with an unusual phenotype is described. The majority of malignant tumour cells did not form E-rosettes, and lacked surface immunoglobulin but reacted with an antiserum to T cells and thymocytes. Localised acid phosphatase and non-specific alpha naphthol acid esterase activities and a prominent, convoluted, nuclear pattern in some neoplastic cells also supported the T cell derivation. The results demonstrate  the importance of using a panel of markers for identification of the cellular derivation of some lymphomas.
D000135:Acid Phosphatase / Q000378:metabolism; D004950:Esterases / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000201:enzymology / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell; D004950:Esterases; D000135:Acid Phosphatase