Roux-Y intestinal bypass for administration of sorbents in uremia.
In order to minimize interaction of sorbents with food and digestive secretions, an intestinal bypass was created for sorbent administration in normal and uremic rats (N = 18) and goats (N = 5). Two separate limbs of small intestine were fashioned, one for food absorption and one for sorbent function, which joined at a Roux-Y anastomosis before the cecum. Particulate sorbent suspensions were injected into the intestine via a cutaneous stoma, and were excreted with food wastes in the feces. In animals with normal kidneys, sorbent function was calculated from changes in fecal and urinary excretion. Nitrogen clearance by the intestinal bypass was 20 to 40% of normal renal clearance in rats and goats. Potassium clearance was 40% of normal renal clearance in rats, and over 100% in goats. Sorbent treatment in anephric animals caused serum urea nitrogen concentrations to stabilize at 210 mg/dl in rats, and 110 mg/dl in goats. Serum potassium concentrations stabilized at 4.5 mEq/liter in rats, and fell to 2 mEq/liter in goats. Water balance was maintained by producing a mild osmotic diarrhea. At least three substances which accumulate in renal failure--urea, potassium, and water--were removed in therapeutically significant amounts.
D000818:Animals; D001806:Blood Urea Nitrogen; D006041:Goats; D007421:Intestine, Small / Q000601:surgery*; D007668:Kidney / Q000378:metabolism; D008722:Methods; D009584:Nitrogen / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D014510:Urease / Q000008:administration & dosage*; D014511:Uremia / Q000378:metabolism / Q000628:therapy*; D014882:Water-Electrolyte Balance; D015040:Zirconium / Q000008:administration & dosage*
D015040:Zirconium; D014510:Urease; D009584:Nitrogen; D011188:Potassium