Influence of Steroidal enzyme inducers on the toxicity of pyrogallol, pargyline and nialamide.
In rats, the toxic manifestations of overdosage with with parcyline (a monoamine oxidase inhibitor) or pyrogallol (a catechol-o-methyltransferase inhibitor) were diminished by treatment with the more potent steroidal (pregnenolone-16alpha-carbonitrile, spironolactone, etc.) or nonsteroidal (phenobarbital) catatoxic substances. Except for significant protection offered by glucocorticoids (triamcinolene, prednisolone acetate) against pargyline, all other pretreatments (progesterone, estradiol, desoxycorticosterone acetate, etc.) either had no influence on or increase the deleterious effects of the two amine inhibitors. Nialamide intoxication was exacerbated by most of these conditioners.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009526:Nialamide / Q000633:toxicity*; D010293:Pargyline / Q000633:toxicity*; D011748:Pyrogallol / Q000633:toxicity*; D051381:Rats; D013256:Steroids / Q000494:pharmacology*
D005938:Glucocorticoids; D013256:Steroids; D011748:Pyrogallol; D010293:Pargyline; D009526:Nialamide