Morphine analgesia and its modification by drugs altering serotonin (5-HT) and dopamine levels in the brain.
Morphine analgesia in mice was significantly potentiated by pretreatment with 5-hydroxytryptophan (5-HTP), especially with higher dose of morphine. Morphine analgesia was antagonised by reserpine. With l-dopa it was antogonised when the dose of morphine was minimal but with increased dosage of morphine, there was no significant effect.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000698:Analgesia; D000818:Animals; D004357:Drug Synergism; D007980:Levodopa / Q000494:pharmacology*; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology*
D007980:Levodopa; D009020:Morphine; D012110:Reserpine; D006916:5-Hydroxytryptophan