title: The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis.
abstract: Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of a diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, "null," hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid HDL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D004247:DNA; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications*; D008297:Male; D009713:Nucleotidyltransferases; D012313:RNA; D011947:Receptors, Antigen, B-Cell
chemical_list: D011947:Receptors, Antigen, B-Cell; D012313:RNA; D004247:DNA; D009713:Nucleotidyltransferases