Effect of the inhibin-like factor from bull spermatozoa on sexual maturation of the male rat.
The s.c. administration for 25 days of the inhibin-like factor extracted from bull spermatozoa to immature 20-day-old male rats reduced serum FSH levels by about 60% and serum LH and testosterone levels by about 50%. However, neither tubular nor interstitial modifications of the histological appearance of the testis were found and there were no changes in the activity of delta 5-3 beta-hydroxysteroid dehydrogenase. The assay described could be usefully employed for evaluating the activities of inhibin-like factors.
D000818:Animals; D002417:Cattle; D003864:Depression, Chemical; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects*; D013094:Spermatozoa / Q000032:analysis*; D013735:Testicular Hormones / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood / Q000378:metabolism
D013735:Testicular Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone