Arginine methyltransferase activity in chronic erythremic myelosis (Diguglielmo syndrome).
Activity of S-adenosylmethionine-dependent arginine methyltransferase was substantially higher in sonicated bone marrow samples from 6 patients with chronic erythremic myelosis than in bone marrow from 3 patients with untreated pernicious anemia, 2 patients with autoimmune hemolytic anemia, and 4 normal persons. Increased activity of this enzyme may be one of the factors contributing to the pathogenesis fo methylated arginines in histones of erythroblasts from patients with chronic erythremic myelosis.
D001120:Arginine; D001853:Bone Marrow / Q000201:enzymology; D002908:Chronic Disease; D004900:Erythroblasts / Q000201:enzymology; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000201:enzymology*; D008780:Methyltransferases / Q000378:metabolism*
D001120:Arginine; D008780:Methyltransferases