Bone marrow colony-forming cells in mice with virus-induced lymphoid leukemia: relation to serum colony-stimulating activity and blood granulocytes.
Mice with advanced lymphoid leukemia have elevated peripheral blood granulocytes and elevated serum colony-stimulating activity, which promotes the in vitro growth of granulocyte and/or macrophage colonies. The number of bone marrow precursor cells of the in vitro granulocyte and/or macrophage colonies varied from normal to 10% of normal. The elevation of colony-stimulating activity correlated best with a combination of increased blood granulocytes and a deficiency of bone marrow precursor cells, which suggested that colony-stimulating activity is a leukopoietin that increases the efficiency and rate of production of granulocytes.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000097:blood* / Q000502:physiology; D006023:Glycoproteins / Q000097:blood*; D006098:Granulocytes / Q000473:pathology*; D007942:Leukemia, Experimental / Q000097:blood / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D003115:Colony-Stimulating Factors; D006023:Glycoproteins