The evaluation of tiodonium chloride as an antiplaque and anticaries agent. III. Evaluation of the antiplaque potential of tiodonium chloride utilizing a rat model.
Tiodonium chloride (4-chlorophenyl-2-thienyliodonium chloride), when used in a twice daily mouthrinse at a concentration of 0.3% for either one or four weeks, inhibited dental plaque formation in rats that had been inoculated with Streptococcus mutans 6715-15 and Actinomyces viscosus T-6. Mouthrinses containing 0.1 and 0.2% tiodonium chloride were also effective in inhibiting plaque, but not as consistently as the 0.3% level.
D000190:Actinomyces / Q000502:physiology; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D004341:Drug Evaluation; D005260:Female; D009067:Mouthwashes / Q000627:therapeutic use; D009861:Onium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D013295:Streptococcus mutans / Q000502:physiology; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D009861:Onium Compounds; D013876:Thiophenes; C020944:tiodonium chloride; D002710:Chlorhexidine