title: Use of prostaglandin, hypertonic saline and oxytocin for second-trimester abortion.
abstract: The management of second-trimester abortion is still not satisfactory with respect to safety and side-effects; it is considered to be in a state of evolution. The goal of this investigation has been to combine, in reduced quantity, prostaglandin and hypertonic saline in order to minimize the complications and side-effects associated with the separate administration of each component. This study documents the results of a random sample of 385 abortions performed in the second trimester, induced by intra-amniotic instillation of prostaglandin (20 mg) and NaCl 5 and 10 g in different volumes and concentrations augmented with oxytocin. In a series of 20 patients, the coagulation profile is presented and the clinical characteristics of 4 groups are compared. This study demonstrated no coagulation defects. The gastrointestinal side-effects were reduced. In spite of the reduced dosage of each component, the instillation abortion interval still remained 17.08 h on the average. Incomplete abortion ranged from 32% to 48.78%. The data presented in this report suggests that combination of prostaglandin, hypertonic saline and oxytocin is feasible for midtrimester abortion.
mesh_terms: D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D015237:Dinoprost; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D010121:Oxytocin; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride
chemical_list: D011460:Prostaglandins F; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D010121:Oxytocin; D015237:Dinoprost