Cell production in the normal and lathyrogenic rat periodontal ligament (PDL).
Thirty male albino rats weighing 200 g. each were separated into two groups. 15 rats received 0.2% 3-amino propionitrile fumarate (BAPN) in drinking water. 15 rats served as controls. Within three weeks eruption rate diminished by 50%. On the 22nd experimental day each rat received one dose of 1 microCi/g. body weight tritiated thymidine (1.9 Ci/mM). 5 rats of each group were then killed after 1 hour; 1 week and 2 weeks. The PDL cell migration rate was evaluated autoradiographically. It diminishes proportionally with the eruption rate. In the BAPN treated animals, the mean total periodontal ligament (PDL) cell count is 55.5% higher than that of the control.
D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D007180:Incisor / Q000502:physiology; D008297:Male; D009805:Odontogenesis; D010513:Periodontal Ligament / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D014078:Tooth Eruption / Q000187:drug effects
D000629:Aminopropionitrile