Antigens expressed by human B lymphocytes and myeloid stem cells.
Antisera prepared against papain-digested spleen cell membranes were known to by cytotoxic for normal and neoplastic human B lymphocytes and for a majority of acute and chronic myeloid leukemic cells. It is now shown that these antisera are also cytotoxic for normal myeloid stem cells (CFU-C), thus providing a probable explanation for their occurrence in myeloid neoplasia.
D001402:B-Lymphocytes / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D013154:Spleen / Q000276:immunology