[Interaction and migration of T- and B-lymphocytes in immune responses during carcinogenesis induced by methylcholanthrene].
The (CBA X C57BL) F1 mice were injected intramuscularly with methylcholantrene (MCA) in a dose of 0.3 mg, and their T- and B-cells ability to cooperate in the immune response against sheep red blood cells, and also migration of these cells from the thymus and the bone marrow to the spleen were studied. The MCA immunosuppressive action proved to be associated with the inhibition of migration and cooperation of T- and B-lymphocytes in the immune response. A conclusion was drawn that the immunosuppressive effect developing during the carcinogenesis was complex and it was realized at various stages of immunogenesis.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D002465:Cell Movement; D004912:Erythrocytes / Q000276:immunology; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000150:complications / Q000276:immunology*; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D008748:Methylcholanthrene
Vzaimodeĭstvie i migratsiia T- i B-limfotsitov v immunnom otvete pri kantserogeneze, indutsirovannom metilkholantrenom.