Enhanced steroidogenesis in hen ovary after malonate administration.
The activities of glucose-6-phosphate dehydrogenase, delta 5-3 beta-hydroxysteroid dehydrogenase and succinic dehydrogenase have been studied histochemically in the ovary of normal and malonate treated hens. Following malonate treatment, glucose-6-phosphate dehydrogenase and delta 5-3 beta-hydroxysteroid dehydrogenase showed increased activities while succinic dehydrogenase activity was diminished significantly. The significance of the above changes has been discussed. The ascorbic acid and cholesterol contents of the ovary were determined to get additional information about steroidogenesis in the gland under such treatment.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002645:Chickens; D002784:Cholesterol / Q000378:metabolism; D002952:Citric Acid Cycle / Q000187:drug effects; D005260:Female; D006153:Guanosine Diphosphate / Q000378:metabolism; D008314:Malonates / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D008314:Malonates; D013256:Steroids; D006153:Guanosine Diphosphate; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D013385:Succinate Dehydrogenase; D001205:Ascorbic Acid