Immunogenicity of enamel protein.
Antisera to enamel proteins have been used primarily as a probe for biochemical and developmental studies of enamel proteins and tooth formation. More recently, the inherent immunogenicity of enamel protein has become a subject for investigation. Papers are reviewed which show that soluble enamel proteins are immunogenic across species barriers, and that solid-phase enamel proteins are immunogenic within a species. New data are presented which demonstrate that enamel proteins are autoantigenic both in vivo and in vitro. Future areas of research are suggested.
D000818:Animals; D000941:Antigens; D001327:Autoimmune Diseases / Q000276:immunology; D002417:Cattle; D002455:Cell Division; D003746:Dental Enamel Proteins / Q000276:immunology*; D007114:Immunization; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D000941:Antigens; D003746:Dental Enamel Proteins