Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001791:Blood Platelet Disorders / Q000139:chemically induced; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D011458:Prostaglandins E / Q000096:biosynthesis; D011725:Pyridines / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis
D001095:Arachidonic Acids; D007093:Imidazoles; D007211:Indoles; D011458:Prostaglandins E; D011725:Pyridines; D013929:Thromboxane B2