Purification and structural characterisation of human HLA-linked B-cell antigens.
The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable similarity in other portions of their polypeptide chains. Thus the genes for their proteins may have evolved by duplication of a common ancestral gene. Another lymphocyte cell surface protein of MW 16,000 (p16) has also been characterised. Both p16 and p44 (the heavy chain of HLA-A,B antigens) have been compared with p29 and p34.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel; D005796:Genes; D008040:Genetic Linkage; D006023:Glycoproteins / Q000032:analysis / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis / Q000302:isolation & purification*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D051379:Mice / Q000276:immunology; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis; D012794:Sialic Acids / Q000032:analysis
D000596:Amino Acids; D006023:Glycoproteins; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007519:Isoantigens; D010455:Peptides; D012794:Sialic Acids