Hereditary angioedema controlled with danazol. Report of a case.
Hereditary angioedema is a condition which should be approached with caution and concern for the patient. The fact that the disease can be fatal cannot be overemphasized. The routine medical history should include questions aimed at identifying these patients. If the angioedema patient is to be treated, provisions must be made for maintenance of an adequate airway. This should include intubation if deemed necessary, and the practitioner should be prepared for a tracheostomy. Close observation following extubation is indicated. A case report in which the patient was controlled with danazol, a synthetic androgen, has been presented. The primary advantage of this drug is a decrease in the various side effects which have been associated with other therapeutic agents used previously in the treatment of hereditary angioedema.
D000328:Adult; D000799:Angioedema / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency; D003613:Danazol / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011245:Pregnadienes / Q000627:therapeutic use*; D014081:Tooth Extraction
D003174:Complement C1 Inactivator Proteins; D011245:Pregnadienes; D003613:Danazol