title: Bone marrow necrosis and extramedullary myeloid tumour necrosis in aggressive chronic myeloid leukaemia.
abstract: A patient with chronic myeloid leukaemia who developed widespread bone marrow necrosis associated wtih evolution of a new cell clone and with aggressive behaviour of the myeloid tumour in extramedullary sites is described. Cell necrosis in extramedullary tumours was also present; the sharp demarcation between zones of necrotic cells and intact cells and the histological evidence of vascular invasion by tumour cells suggest a vascular basis for cell necrosis.
mesh_terms: D001855:Bone Marrow Diseases / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000473:pathology*