Comparison of canine distemper virus strains in gnotobiotic dogs: effects on lymphoid tissues.
The effects of infection on various aspects of lymphoid function in gnotobiotic dogs with 2 virulent strains of canine distemper virus (CDV), Snyder-Hill CDV and R252-CDV, were compared. Both infections resulted in a viremia-related lymphopenia which was nonselective in that the percentages of B and T cells remained unchanged throughout the observation period. Nonfatal Snyder-Hill-CDV infection resulted in a transient depression of in vitro lymphocyte responses to phytohemagglutinin-P, whereas R252-CDV produced prolonged in vitro suppression of phytohemagglutinin-P stimulation. The differences observed are of minor significance and do not explain the differences in central nervous system demyelinating potential between these 1 strains of CVD.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D004216:Distemper / Q000276:immunology* / Q000473:pathology; D004217:Distemper Virus, Canine; D004285:Dogs; D005856:Germ-Free Life; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology*; D008231:Lymphopenia / Q000662:veterinary; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D014774:Virulence