Virus production and hemoglobin synthesis in variant lines of dimethyl sulfoxide-treated Friend erythroleukemia cells.
Variant Friend erythroleukemia cell clones were compared in regard to their response to dimethyl sulfoxide and in their abilities to synthesize virus and hemoglobin. Clear evidence was obtained that cellular growth is required for virus production. The effects of dimethyl sulfoxide on virus production were not observed in cell lines that were resistant to growth perturbation by the compound. Studies of cell variants that were defective in either hemoglobin or virus synthesis indicate that these activities are independently regulated.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D005622:Friend murine leukemia virus / Q000254:growth & development* / Q000276:immunology; D006454:Hemoglobins / Q000096:biosynthesis*; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism* / Q000382:microbiology; D007942:Leukemia, Experimental / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D014779:Virus Replication / Q000187:drug effects*
D000956:Antigens, Viral; D006454:Hemoglobins; D004121:Dimethyl Sulfoxide