L-asparaginase effect on antithrombin-III levels.
The effect of L-asparaginase (L-asp) therapy on circulating antithrombin-III (AT-III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT-III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT-III levels, followed by a protracted recovery beyond the period of L-asp exposure. One of the three patients developed a reversible venous thrombosis of the arm. The mechanism of the L-asparaginase effect may be related to peripheral degradation of AT-III or to inhibition of production.
D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D001215:Asparaginase / Q000009:adverse effects*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013924:Thrombophlebitis / Q000139:chemically induced
D000990:Antithrombin III; D001215:Asparaginase