A preliminary clinical study in the use of misonidazole in cancer of the head and neck.
The value of misonidazole in advanced head and neck cancer was examined in 3 ways and the preliminary results are reported in a randomized study with large fractions of irradiation, when misonidazole appeared to confer no advantage; whereas in previously (partially) treated patients misonidazole was possibly useful. The combination of hyperbaric oxygen and misonidazole did not appear to be toxic.
D000328:Adult; D000368:Aged; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008875:Middle Aged; D009593:Nitroimidazoles / Q000009:adverse effects / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents; D011897:Random Allocation
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents