Spontaneous hepatomas in mice inbred from Ha:ICR Swiss stock: effects of sex, cedar shavings in bedding, and immunization with fetal liver or hepatoma cells.
Mice from Ha:ICR noninbred Swiss stock were mated brother X sister for 21--25 generations and then maintained up to the age of 33 months. Hepatomas developed in 62.8% of 86 males autopsied at 349--999 days of age (mean age = 21.1 mo). Of 130 females, 6.9% had hepatomas when autopsied at 328-825 days of age (mean age = 18.7 mo). Hepatoma incidence in males at 18 months of age was not affected by the presence or absence of cedar shavings in the bedding or by immunization of 3-month-old males with 2 weekly inoculations of 150 microgram (protein) sonicate of fetal liver or spontaneous hepatoma cells.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D005260:Female; D005333:Fetus / Q000276:immunology; D008099:Liver / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000209:etiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D012737:Sex Factors; D014934:Wood
D000941:Antigens; D000951:Antigens, Neoplasm