title: Paroxysmal nocturnal hemoglobinuria terminating as erythroleukemia.
abstract: A case of a patient who developed erythroleukemia 3 years into the course of paroxysmal nocturnal hemoglobinuria (PNH) is presented. A case of erythroleukemia with a positive sucrose lysis test has been reported, but our case appears to be the first with a long clinical course of PNH evolving into erythroleukemia. The association between these two diseases, their possible clonal origin, and how they fit into the myelodysplastic syndromes are discussed.
mesh_terms: D010131:Aminosalicylic Acid; D001856:Bone Marrow Examination; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000209:etiology*; D008297:Male; D008875:Middle Aged
chemical_list: D010131:Aminosalicylic Acid