Histomorphologic investigations of dentinogenesis in incisors of offspring of cyclophosphamide-treated pregnant rats.
Eight days old offspring of six rats treated with single doses of 40 mg/kg and 50 mg/kg of cyclophosphamide on the 20th day of pregnancy constituted two experimental groups. Group 1 (40 mg/kg) comprised 21 animals, Group 2 (50 mg/kg) 14 animals. Histomorphologic investigations of the maxillary and mandibular incisors revealed the following changes: (1) dental constrictions, (2) niche-like dentinal defects, (3) scalloping of the amelodentinal junction, (4) incremental line in the pre-experimental tooth segment, (5) external resorptions, and (6) diffuse edema in the pre-experimental part of pulp. Constrictions and niches qualitatively concurred with those previously observed in adult rats of the same strain, but the lesion frequency was essentially higher in the offspring. Further, the additional change of external resorptions was evinced by the offspring incisors, and changes only rarely observed in adults, such as scalloping of the dentinoenamel junction and a dentinal incremental line, constituted frequent findings in the offspring material.
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D003810:Dentinogenesis / Q000187:drug effects*; D003811:Dentinogenesis Imperfecta / Q000139:chemically induced; D005260:Female; D007180:Incisor / Q000187:drug effects* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013723:Teratogens
D013723:Teratogens; D003520:Cyclophosphamide