title: Multiple red cell antigen loss in acute granulocytic leukemia.
abstract: Loss of certain red blood cell antigens has been described in various disease states including acute granulocytic leukemia (AGL). This paper describes the loss of blood group A antigen in three patients, two with AGL and a third with a myeloproliferative disorder similar to AGL which developed following total body irradiation for malignant, well-differentiated lymphocytic lymphoma. In the latter case, the onset of the myeloproliferative disease correlated with the loss of A antigen. In addition to A antigen loss, all three patients' red cells showed the loss of Lewis antigen, a finding previously unreported. Finally, the two patients with AGL also exhibited the loss of I antigen from their red cells.
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D001789:Blood Group Antigens; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007048:I Blood-Group System; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000276:immunology; D007983:Lewis Blood Group Antigens; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000276:immunology; D012463:Saliva / Q000276:immunology
chemical_list: D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D007048:I Blood-Group System; D007983:Lewis Blood Group Antigens