Clinical studies with misonidazole.
The preliminary details of a randomized clinical trial of misonidazole for the radiotherapy of Grades 3 and 4 cerebral astrocytoma are described. Plasma concentrations of misonidazole and its O-demethylated metabolite, determined by high-pressure liquid chromatography analysis, are reported for 8 patients with astrocytoma, 1 with carcinoma of the bronchus and 1 with carcinoma of the breast. In the latter case, tumour concentrations are also presented.
D000328:Adult; D001254:Astrocytoma / Q000378:metabolism / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D001943:Breast Neoplasms / Q000378:metabolism; D006801:Humans; D009593:Nitroimidazoles / Q000378:metabolism / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents; D011897:Random Allocation; D013997:Time Factors
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents