title: [Immunological characteristics of lymphocytes during intensive treatment maintaining remission of acute lymphoblastic leukemia in children and following withdrawal from chemotherapy].
abstract: In 22 children with lymphoblastic leukaemia peripheral blood lymphocytes were studied during 2.5 years of remission-maintaining treatment, and in 7 cases also after stopping treatment. Lymphocytes T and B were identified and lymphocyte surface receptors for complement and for the Fc fragment of IgF were determined. The immunological reactivity of lymphocytes was determined also using the test of PHA-induced blastic transformation. It was found that prolonged chemotherapy caused depression of lymphocytes B in the first place. A fall was observed also in the proportion of cells undergoing transformation. It was shown that after cessation of treatment PHA-reactivity and normal values of lymphocyte subpopulations returned.
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Charakterystyka immunologiczna limfocytów w trakcie intensywnego leczenia podtrzymujacego remisje ostrej białaczki limfoblastycznej u dzieci oraz po jego zaprzestaniu.