Hepatitis associated antigen, autoantibodies and serum immunoglobulin levels in patients with liver injury following administration of antituberculosis drugs.
32 patients with liver injury following the administration of tuberculosis drugs were examined for HAA, ANA, SMA and serum immunoglobulin levels. HAA was found in 38-7% of patients. SMA were detected in some HAA positive as well as in HAA negative cases. ANA except in one case were found in the HAA negative group. Serum IgM levels are significantly higher in patients with liver injury as compared to the normal values. The highest levels of IgG and IgM were found in the ANA or/and SMA-positive cases.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear; D000995:Antitubercular Agents / Q000009:adverse effects*; D001323:Autoantibodies; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D005260:Female; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology
D000974:Antibodies, Antinuclear; D000995:Antitubercular Agents; D001323:Autoantibodies; D006514:Hepatitis B Surface Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M