title: Second primary neoplasms following ovarian cancer.
abstract: Follow-up surveys of patients with ovarian cancer revealed an increased risk of second primary cancers of the uterine corpus, colon, bladder, breast, and hematopoietic system. The excess risk or uterine corpus cancer was independent of therapy. The risk of colon cancer was increased in all treatment groups but was especially high among patients receiving radiation or chemotherapy. The predisposition to other neoplasms was limited to certain treatment groups: bladder cancer to irradiation, leukemia to chemotherapy, and lymphoma to either modality. The pattern of second neoplasms following ovarian cancer appears to be influenced by therapy as well as by common etiologic factors.
mesh_terms: D000477:Alkylating Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007938:Leukemia / Q000453:epidemiology; D008223:Lymphoma / Q000453:epidemiology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology* / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000628:therapy; D012306:Risk; D014481:United States; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology
chemical_list: D000477:Alkylating Agents