Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer.
A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral blood white cells. In addition, a karyotypic abnormality was found in peripheral blood and marrow cells but not in skin fibroblasts. The data are consistent with a clonal origin of this leukemia.
D002875:Chromosomes; D002999:Clone Cells; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D008875:Middle Aged
D005954:Glucosephosphate Dehydrogenase