Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4.
An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines. The human enzyme marker segregates exclusively with chromosome 4 in a series of well characterized man-mouse somatic cell hybrid clones from our clone bank. This observation supports the assignment of a structural gene for QDPR to human chromosome 4.
D000818:Animals; D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D004093:Dihydropteridine Reductase / Q000235:genetics*; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D051379:Mice; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics*; D010641:Phenotype
D005819:Genetic Markers; D004093:Dihydropteridine Reductase; D009247:NADH, NADPH Oxidoreductases