Structure of the human G gamma-A gamma-delta-beta-globin gene locus.
We have constructed a physical map of the human G gamma-, A gamma-, delta-, and beta-globin genes. The previously described maps of the fetal and adult beta-like globin genes have been linked to one another by identification of a DNA fragment, generated by BamHI, that contains part of each of the A gamma- and delta-globin genes. The map obtained, which spans more than 40 kilobases, shows the following intergene distances: between G gamma and A gamma, 3500 base pairs; between A gamma and delta, 13,500 base pairs; and between delta and beta, 5500 base pairs. All genes are transcribed from the same DNA strand.
D000328:Adult; D001482:Base Composition; D001483:Base Sequence; D004247:DNA / Q000378:metabolism; D004262:DNA Restriction Enzymes; D005260:Female; D005796:Genes; D005914:Globins / Q000096:biosynthesis*; D006455:Hemoglobins, Abnormal; D006720:Homozygote; D006801:Humans; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D013154:Spleen / Q000378:metabolism; D014158:Transcription, Genetic
D006455:Hemoglobins, Abnormal; D005914:Globins; D004247:DNA; D004262:DNA Restriction Enzymes