[Glucose-6-phosphate dehydrogenase and pyruvate kinase activity and the content of adenosine triphosphate in the erythrocytes of leukemic patients].
The activity of G-6PD and PK in erythrocytes and ATP content in erythrocyte hemolysate in patients with leucosis (acute, chronic myelo- and chronic lympholeucosis) was investigated. A reduced G-6PD activity was found in the majority of the patients examined, being most markedly manifested in the patients with chronic lympholeucosis and least--in the patients with chronic myeloleucosis. About 50 per cent of the patients with acute leucosis and chronic lympholeucosis have reduced PK activity and in those with chronic myeloleucosis -- increased. ATP content is increased in patients with chronic myeloleucosis and in the rest of the patients -- normal. A disturbance of glucose metabolism in erythrocytes in patients with leucosis is concluded to exist.
D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000097:blood*; D004789:Enzyme Activation; D004912:Erythrocytes / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D007938:Leukemia / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000097:blood; D007951:Leukemia, Myeloid / Q000097:blood; D011770:Pyruvate Kinase / Q000097:blood*
D000255:Adenosine Triphosphate; D005954:Glucosephosphate Dehydrogenase; D011770:Pyruvate Kinase
Aktivnost na glikozo-6-fosfat-dekhidrogenaza, piruvat-kinaza i sudurzhanie na adeniozin-trifosfat v eritrotsitite u levkozno bolni.