Ultrastructure of a plasma-cell myeloma in the mandible.
Tumor cells exhibited large amounts of rough endoplasmic reticulum arranged in a lamellar pattern, large numbers of mitochondria with a perinuclear distribution, and a prominent Golgi complex, but only a small number of immunoglobulin granules. No crystalline structures of immunoglobulins were observed. Nuclei exhibited patchy condensation of chromatin and large nucleoli. The ultrastructural features suggest that this case could be a "resecretory" myeloma.
D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000648:ultrastructure*; D009101:Multiple Myeloma / Q000648:ultrastructure*; D009940:Organoids / Q000648:ultrastructure