title: The response of human tumour metastases to radiation and misonidazole.
abstract: In an attempt to investigate the radiosensitivity effect of the nitroimidazole misonidazole in man, sequential tumour volume measurements have been performed in 4 patients with metastatic malignant disease in order to compare the growth delay induced by radiation given before of 4 hours after the oral administration of the drug. One study was not completed, and there was no evidence of radiation sensitization in 2 patients. The results in the fourth patient were consistent with a small enhancement of radiation effect. Drug blood levels were followed on 9 occasions and tumour drug concentration measured in 1 patient.
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D009362:Neoplasm Metastasis / Q000532:radiotherapy*; D009593:Nitroimidazoles / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy
chemical_list: D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents