Hypoimmunoglobulinaemia and aplastic anaemia.
Serum immunoglobulin levels were estimated in 19 patients with aplastic anaemia. Although the mean levels for IgG, IgA and IgM for the group as a whole were within the normal range, 8 individual cases showed low levels of one or more immunoglobulin class, suggesting a disturbance in immunoglobulin production. One of these patients had a thymoma, and another positive tests for anti-nuclear factor, but there was no evidence of auto-immune disease in the others. It is suggested that 'aplastic anaemia' may sometimes be a disease due to injury of a stem cell subserving both haemopoietic and immunological function.
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications* / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases; D002648:Child; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013945:Thymoma / Q000000981:diagnostic imaging; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging
D000974:Antibodies, Antinuclear; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M