The effect of selective monoamine oxidase inhibitors, clorgyline and deprenyl, upon tissue glycogen stores and blood glucose levels.
The effect of selective monoamine oxidase (MAO) inhibitors clogyline and deprenyl upon glycogen stores in brain, heart and liver and upon blood glucose were examined for a possible link between the activity of the oxidase and metabolism of carbohydrates. The experiments were performed in normally fed rats and rats subjected to starvation for 24 hours. This study showed that selective inhibitors of MAO affect carbohydrate metabolism and that this may be the consequence of increased monoamines in the organs and circulation. However, there was no correlation between the selective inhibition of a particular form of MAO and glycogen metabolism.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D003010:Clorgyline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010627:Phenethylamines / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology*
D001786:Blood Glucose; D010627:Phenethylamines; D011437:Propylamines; D012642:Selegiline; D006003:Glycogen; D003010:Clorgyline