Immunological findings in immunoblastic lymphadenopathy. A detailed case study.
Several immunological parameters were investigated in a patient with immunoblastic lymphadenopathy (IBL). An increased concentration of polyclonal immunoglobulins, the presence of autoantibodies in the serum and an increased level of B lymphocytes with an abnormal DNA synthesis response to LPS in peripheral blood were the most salient features. The findings suggest that in IBL there is a numerical as well as a functional alteration of peripheral blood lymphocytes. We propose that the alteration was due to either an escape of lymphocytes from central lymphatic organs or a defect in maturation of peripheral blood lymphocytes.
D001323:Autoantibodies / Q000032:analysis; D001402:B-Lymphocytes / Q000378:metabolism; D002999:Clone Cells / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008206:Lymphatic Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000378:metabolism
D001323:Autoantibodies; D003176:Complement C3; D007136:Immunoglobulins; D004247:DNA