Self-stimulation of the MFB or VTA after microinjection of haloperidol into the prefrontal cortex of the rat.
Haloperidol, a dopamine receptor antagonist, was microinjected in doses of 12 or 24 microng into the prefrontal cortex of the rat. Its effects on self-stimulation of the ventral tegmental area (VTA) or the medial forebrain bundle (MFB) were examined. It was found that these injections failed to attenuate self-stimulation at either structure. However, when haloperidol was injected into the caudate-putamen complex, a decrease in self-stimulation occurred within these structures. These results suggest that dopamine in the medial prefrontal cortex is not necessarily a part of the neurochemical substrate underlying self-stimulation of the ventral tegmental area or medial forebrain bundle.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005625:Frontal Lobe / Q000187:drug effects; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects*; D008845:Microinjections; D009434:Neural Pathways / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D012653:Self Stimulation / Q000187:drug effects*; D013681:Tegmentum Mesencephali / Q000187:drug effects*; D013997:Time Factors
D011954:Receptors, Dopamine; D006220:Haloperidol