Chloride transport and acid secretion in stomach.
Chloride transport in isolated frog gastric mucosa is known to include major components due to active transport and exchange diffusion, and a minor component due to passive diffusion, but the sites responsible for moving Cl- within the mucosa have not been identified. The present study shows that the method used by Zerahn and others to measure transport pool yields an apparent Cl- pool which is close to the Cl- content of mucosal cells measured by chemical or radioactive means. Uptake of Cl- by the mucosal cells across the luminal surface in 2 min is rapid, constituting over one-half of the steady state cell content. The results suggest that much of this uptake occurs by exchange diffusion of Cl- at the secretory surface.
D000818:Animals; D001001:Anura; D001693:Biological Transport, Active; D002712:Chlorides / Q000378:metabolism*; D004058:Diffusion; D005110:Extracellular Space / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D066298:In Vitro Techniques; D008353:Mannitol / Q000378:metabolism; D011892:Rana catesbeiana; D011894:Rana pipiens
D002712:Chlorides; D008353:Mannitol