title: [Clinical and histological studies on the effect of a surfactant containing toothpaste on the gingiva].
abstract: A clinical double blind trial on 98 volunteers was undertaken with the aid of the SB Index to show the effects on the gum of a tooth paste containing detergents. It resulted in a significant increase of the SBI after 6 weeks of a tooth paste with a high content of surface active substances. With the light microscope changes are demonstrable in the Stratum spinosum which could be identified electron-microscopically as a strong increase of bundles of filament in the cytoplasm. The contradiction between clinical and morphological findings is explained by the assumption that the greatincrease in filament bundles leads to a lowering of the adaptability of the epithelium and consequently to increased tendency to bleed, especially in response to mechanical irritation.
mesh_terms: D000328:Adult; D003802:Dentifrices; D005881:Gingiva / Q000187:drug effects* / Q000648:ultrastructure; D005884:Gingival Hemorrhage / Q000175:diagnosis; D006801:Humans; D013501:Surface-Active Agents / Q000494:pharmacology*
chemical_list: D003802:Dentifrices; D013501:Surface-Active Agents
vernacular_title: Klinische und histologische Untersuchungen über den Einfluss einer netzmittelhaltigen Zahnpaste auf die Gingiva.