title: On the nature and etiology of vascular ectasias of the colon. Degenerative lesions of aging.
abstract: Vascular lesions of the right colon are being diagnosed increasingly as a cause of lower intestinal bleeding, but their nature and occurrence, primarily in the elderly, remains unexplained. Colons from patients with clinical and angiographic diagnoses of cecal vascular lesions were studied by injection and clearing, and by histological sections. In all injected specimens one or more mucosal vascular ectasias were identified. The mucosal lesions appeared to be secondary to dilated tortuous submucosal veins which were the more prominent feature and were often present without the mucosal ectasia. This suggests that ectasias are caused by chronic, intermittent, low grade obstruction to submucosal veins with dilation and tortuosity initially  of submucosal veins, then of venules, capillaries, and arteries of the mucosal vascular unit. Ultimately, precapillary sphincters lose their competency, producing small arteriovenous communications. The concept that ectasias are degenerative lesions was evaluated by studying 15 right colons resected for carcinoma with no history of bleeding. Mucosal ectasias were identified in four colons and submucosal ectasias in eight. These investigations suggested that these lesions: (1) are vascular ectasias developing as a degenerative process of aging, (2) are present with or without bleeding in a significant portion of the population over 60 years of age, (3) are multiple more often than single, and (4) may represent the commonest cause of major lower intestinal bleeding in the elderly.
mesh_terms: D000368:Aged; D000375:Aging; D001018:Aortic Diseases / Q000150:complications; D002432:Cecum / Q000098:blood supply; D002784:Cholesterol; D003106:Colon / Q000098:blood supply*; D003108:Colonic Diseases / Q000150:complications / Q000473:pathology; D003110:Colonic Neoplasms / Q000098:blood supply / Q000473:pathology; D004108:Dilatation, Pathologic; D004241:Diverticulum, Colon / Q000150:complications; D004620:Embolism, Fat / Q000473:pathology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply; D008875:Middle Aged; D012826:Silicone Elastomers; D014652:Vascular Diseases / Q000150:complications / Q000209:etiology* / Q000473:pathology
chemical_list: D012826:Silicone Elastomers; D002784:Cholesterol