title: Another approach to in vivo estimation of genetic damage in humans.
abstract: Direct measurements of the genetic hazards to man have been determined previously by the appearance of elevated in vivo levels of chromosome aberrations. Here we report that interindividual variations in N-acetoxy-2-acetyl-aminofluorene-induced unscheduled DNA synthesis values parallel the actual in vivo levels of chromosome damage and, therefore, may be a rapid useful supplement in genetic risk assessment for humans.
mesh_terms: D015073:2-Acetylaminofluorene; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens
chemical_list: D009153:Mutagens; D004247:DNA; D015073:2-Acetylaminofluorene