HLA antigens and mitogen responsiveness in multiple sclerosis.
Thirty-one MS patients were studied for their in vitro response to lymphocyte mitogens. Patients with HLA antigens A3 and/or B7 had lower mean peak responses to all three mitogens compared to A3, B7-negative patients. The difference in the mean peak responses to Con A were significantly different at a level of p less than 0.05. This supports the concept of a histocompatibility-linked T-cell deficiency in many patients with MS.
D006680:HLA Antigens / Q000032:analysis*; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008934:Mitogens; D009103:Multiple Sclerosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D008934:Mitogens