Distribution of binding sites for 125I-labeled alpha-bungarotoxin in normal and deafferented antennal lobes of Manduca sexta.
125I-Labeled alpha-bungarotoxin has been used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth Manduca sexta. Toxin-binding sites are confined to synaptic regions in deafferented lobes. These findings suggest that receptors can develop in the insect central nervous system independently of normal synaptic influences.
D000344:Afferent Pathways; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002038:Bungarotoxins / Q000378:metabolism*; D003714:Denervation; D007915:Lepidoptera / Q000378:metabolism*; D009036:Moths / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism
D002038:Bungarotoxins; D011950:Receptors, Cholinergic