Tissue culture and histologic study of a new elastomer.
A new silicone material, Silastic MDX 4-4210, was tested by tissue culture and tissue implantation to compare host reaction with known toxic and nontoxic materials. It was not found to be toxic to a monolayer of HEL cells, and it evoked a minimal foreign body reaction when implanted in albino rats. Further clinical studies are indicated to evaluate host reaction of this silicone in long-term contact with human mucous membrane and skin tissue.
D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology; D046508:Culture Techniques; D004129:Dimethylpolysiloxanes; D005069:Evaluation Studies as Topic; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008168:Lung; D008297:Male; D051381:Rats; D012408:Rubber / Q000494:pharmacology; D012826:Silicone Elastomers / Q000494:pharmacology*; D012867:Skin / Q000033:anatomy & histology
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; C020964:MDX 4-4210; D012826:Silicone Elastomers; D012408:Rubber; D003094:Collagen