title: Diphenylhydantoin induced gingival hyperplasia in ferrets: a precautionary note.
abstract: Diphenylhydantoin appears to modify the tissue response in ferrets to a gingival irritant. In the present study, ferrets were tested for the tissue response to a local irritant in their maxillary right quadrant, while their maxillary left quadrant was the control. A low incidence of hyperplasia was induced only in irritated gingival tissue of animals receiving DPH. The problems encountered in comparing the hyperplasia produced in ferrets and humans were also discussed.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005289:Ferrets; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D005891:Gingivitis / Q000150:complications / Q000473:pathology; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
chemical_list: D010672:Phenytoin