Ribavirin: efficacy in the treatment of murine autoimmune disease.
Ribavirin, a drug with known antiviral activity, was given to mice with established lupus nephritis. Ribavirin was effective in prolonging survival, reducing the titer of antibodies to DNA, and reversing proteinuria. Other antiviral agents were not effective in the dosages used.
D000085:Acetates / Q000627:therapeutic use; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy*; D004247:DNA / Q000276:immunology; D007978:Levamisole / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D011507:Proteinuria / Q000188:drug therapy; D012254:Ribavirin / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*; D014740:Vidarabine / Q000627:therapeutic use
D000085:Acetates; D000974:Antibodies, Antinuclear; D009943:Organophosphorus Compounds; D012263:Ribonucleosides; D007978:Levamisole; D012254:Ribavirin; D004247:DNA; D014740:Vidarabine