title: Oestrogen receptor studies in carcinoma of the endometrium, carcinoma of the uterine cervix and other gynaecological malignancies.
abstract: The tissues from 30 cases of endometrial cancer and 44 cases of cervical cancer were examined for oestrogen receptor activity. Twenty of the endometrial and 9 of the cervical tumours contained oestrogen receptor levels above 4 fmol/mg protein. The proportion of oestrogen receptor-positive tumours was significantly greater in adenocarcinomas of the cervix than in squamous carcinomas of the cervix. Tissues from 3 mixed mesodermal tumours of the uterus, 2 carcinomas of the vagina, a carcinoma in situ of the cervix and a carcinoma in situ of the endometrium were receptor-negative. One ovarian carcinoma and a single case of uterine sarcoma were receptor-positive. The implications of these findings in relation to hormonal therapies are discussed.
mesh_terms: D000230:Adenocarcinoma / Q000503:physiopathology; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology; D004717:Endometrium; D005260:Female; D005833:Genital Neoplasms, Female / Q000503:physiopathology; D006801:Humans; D010053:Ovary / Q000503:physiopathology; D011485:Protein Binding; D011960:Receptors, Estrogen / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000378:metabolism / Q000503:physiopathology*; D014594:Uterine Neoplasms / Q000145:classification / Q000503:physiopathology*
chemical_list: D011960:Receptors, Estrogen