Genetic controls and cellular interactions in antibody formation.
Both thymus-derived lymphocytes (T cells) and bone marrow--derived lymphocytes (B cells) play critical roles in specific antibody responses to antigens. Genetic controls of the antibody response in mammals have been found to reside largely within the major histocompatibility complex where different genes appear to code for immune response (Ir), immune suppression (Is), and cell interaction (CI) molecules.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D005796:Genes; D006168:Guinea Pigs; D006648:Histocompatibility; D006801:Humans; D007111:Immunity, Cellular; D007125:Immunogenetics; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology