title: Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
abstract: Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D003433:Crosses, Genetic; D005809:Genes, Regulator; D051379:Mice; D008815:Mice, Inbred Strains; D011995:Recombination, Genetic; D012083:Renin / Q000235:genetics* / Q000378:metabolism; D013363:Submandibular Gland / Q000201:enzymology*
chemical_list: D012083:Renin