Effect of streptolysin S on human and mouse T and B lymphocytes.
The effect of streptolysin S on T and B human and mouse lymphocytes was studied. The dose-dependent inhibition of T cell rosette formation was observed, and this was accompanied by a dose-dependent cytotoxicity. The existence of a difference in the degree of susceptibility of T and B cells to the cytotoxic effect of streptolysin S is shown.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007104:Immune Adherence Reaction; D051379:Mice; D013301:Streptolysins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D013301:Streptolysins