Procoagulant specificity of factor VIII inhibitor.
Nine haemophilia A patients with an inhibitor to factor VIII procoagulant and eight without an inhibitor were studied for the presence of an inhibitor to von Willebrand factor (vWf) in a quantitative ristocetin-induced platelet aggregation system. The mean vWf, factor VIII related antigen (FVIII Ag) and vWf:FVIII Ag ratio were not significantly different in the two groups (P greater than 0.6). The inhibitor plasmas did not reduce the wWf level in normal plasma after a 2 h incubation. The factor VIII inhibitor is highly specific for the procoagulant function of the factor VIII complex.
D000941:Antigens / Q000032:analysis; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000276:immunology; D006467:Hemophilia A / Q000097:blood; D006801:Humans; D010974:Platelet Aggregation; D014841:von Willebrand Factor / Q000037:antagonists & inhibitors
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII