title: Effects of lesions of various medial forebrain bundle components on lateral hypothalamic self-stimulation.
abstract: Unilateral lesions of various medial forebrain bundle components were assessed for their effects on lateral hypothalamic self-stimulation. Damage of areas containig nigrostriatal dopaminergic or ascending noradrenergic neurons had negligible effects on bar pressing, tail moving and alley running for hypothalamic stimulation. Lesions which appeared to destroy most or all of the catecholaminergic fibers in the posterior medial forebrain bundle virtually eliminated reinforced bar pressing and tail moving, but only partially suppressed alley running. The results suggest that brain stimulation reinforcement of the bar press and tail movement tasks depends upon the integrity of neural tissue in the area of the catecholaminergic pathways of the medial forebrain bundle, but not upon specific dopaminergic or noradrenergic systems. The data further suggest that the reinforcement of alley running is at least partially mediated by different neural tissue (possibly non-catecholaminergic) at the level of the posterior medial forebrain bundle lesions.
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D012653:Self Stimulation / Q000502:physiology*
chemical_list: D004298:Dopamine; D009638:Norepinephrine