title: Effects of amyl nitrite on phasic aortocoronary bypass graft blood velocity in man.
abstract: With the use of a Doppler flowmeter catheter, phasic instantaneous aortocoronary saphenous vein bypass graft blood velocity was continuously measured during the inhalation of amyl nitrite in 20 closed-chest conscious subjects. Administration of amyl nitrite augmented peak diastolic and systolic graft blood velocity within 10 seconds and maximal blood velocities were recorded between 8 and 60 seconds after inhalation. Control mean (+/- 1 S.D.) bypass graft blood velocity was 25 +/- 10 cm. per second and after amyl nitrite 46 +/- 14 cm. per second, resulting in an average 84 per cent rise of blood velocity. It is concluded that amyl nitrite increases aortocoronary bypass graft blood velocity, suggesting a possible enhancement of blood flow to the distal native circulation in patients so operated upon.
mesh_terms: D000328:Adult; D000368:Aged; D000680:Amyl Nitrite / Q000494:pharmacology*; D001011:Aorta; D001783:Blood Flow Velocity; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D012501:Saphenous Vein / Q000637:transplantation; D014182:Transplantation, Autologous
chemical_list: D000680:Amyl Nitrite