[Acute myeloid leukemia with megakaryocytic predominance and malignant megakaryocyte proliferation. Apropos of 3 cases].
Three cases of acute myeloid leukemia with megakaryocyte predominance are reported. In the first case megakaryocytosis was particularly evident in bone marrow, liver and spleen. In the second case high content of megakaryocytes was observed in the bone marrow and spleen, during the preleukemic phase only. Third case exhibited a strong predominance of megakaryocytes exclusively within the bone marrow. The characteristics of such observations and their nosologic position within myeloproliferative disorders group are discussed, with special reference to modern views concerning myeloid leukemia.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology* / Q000502:physiology; D009196:Myeloproliferative Disorders / Q000150:complications; D013154:Spleen / Q000473:pathology
Leucémie myéloïde aiguë à prédominance mégacaryocytaire et proliférations mégacaryocytaires malignes. A propos de trois observations.