The evaluation of tiodonium chloride as an antiplaque and anticaries agent. I. Preliminary in vitro and in vivo studies.
Tiodonium chloride was evaluated for its efficacy against Streptococcus mutans. Depending upon the concentration used, it was found to have either bacteriocidal or bacteriostatic activity against S mutans and ti inhibit the accumulation of plaque formed in vitro by this organism. When applied as a mouthrinse in hamsters infected with S mutans, tiodonium chloride significantly reduced the accumulation of dental plaque. Chlorhexidine gluconate was tested as a positive control in the in vivo experiment.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006224:Cricetinae; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D004341:Drug Evaluation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009861:Onium Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013295:Streptococcus mutans / Q000187:drug effects; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D009861:Onium Compounds; D013876:Thiophenes; C020944:tiodonium chloride