Tumorigenic effect of 1-hydrazinophthalazine hydrochloride in mice.
A solution of 0.125% 1-hydrazinophthalazine hydrochloride, an antihypertensive drug widely used in humans, was given continuously in drinking water for the life-spans of randomly bred Swiss mice. Consumption of the chemical significantly increased the lung tumor incidence from 36 to 60% in females and from 26 to 46% in males, compared to controls. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000378:metabolism / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced
D006830:Hydralazine