Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.
A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described.
D000818:Animals; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D007953:Leukemia, Radiation-Induced; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D014965:X-Rays