[Determination of anti-DNA and anti-RNA antibodies in serum and CSF by a new counterimmunoelectrophoresis method].
A new quantitative counterimmunoelectrophoresis technique allows the determination of anti-DNA and anti-RNA antibodies in the serum and the unconcentrated CSF. Normal sera (but not normal CSF) presents anti-DNA and anti-RNA antibodies probably of IgG type. Pathological results (elevated serum values and/or presence of anti-nucleic  antibodies in CSF) are observed in some neurological diseases especially SSPE, multiple sclerosis and, generally speaking infectious diseases. A very significant correlation exists between the presence of anti-nucleic antibodies in CSF and a local (intrathecal) IgG synthesis. The same correlation is observed with oligoclonal aspect in CSF. In some cases a percentage of anti-nucleic antibodies higher in CSF than in serum may indicate the persistence of an infectious agent inside the central nervous system.
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D002555:Cerebrospinal Fluid / Q000276:immunology*; D003378:Counterimmunoelectrophoresis / Q000379:methods*; D004247:DNA / Q000276:immunology*; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods*; D012313:RNA / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D012313:RNA; D004247:DNA
Dosage des anticorps anti-ADN et anti-ARN dans le sérum et le LCR par une nouvelle méthode de contre-immunoélectrophrèse