[Possible vertebrate use of a mechanism of chromatin reduction to fuse the V and C genes of immunoglobulins].
Diminution of a chromatin fragment separating V- and C-immunoglobulin genes is suggested as possible mechanism of fusion of V- and C-genes into one functionally active cisrtron. During the early stage of immunodifferentiation of lymphocytes, the chromatin fibrills unfold, and V- and C-genes bring together by DNA-DNA and DNA-protein interaction. The endonucleases excise the chromatin fragment interlocated between V- and C-genes, then the repair enzymes restore the intactness of chromating structure by fusion of V- and C-genes. A number of human pathologic syndromes, the elimination of nucleus during erythrocyte differentiation in mammals indicate the possibility of manifestation on diminution mechanism in vertebrates. Fusion of V- and C-genes by chromatin diminution fits the number of immunologic phenomena, and it may display for different paths of V-gene coding and may be experimentally verified.
D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D002872:Chromosome Deletion; D005796:Genes; D005818:Genetic Engineering; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007136:Immunoglobulins / Q000235:genetics*; D014178:Translocation, Genetic
D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins
Vozmozhnoe ispol'zpvanie pozvonochnymi mekhanizma diminutsii khromatina dlia sliianiia V- i C-genov immunoglobulinov.