Restoration of the T lymphoid system of nude mice: different regeneration of neonatal and adult thymuses.
When a neonatal thymus and an adult (reticuloepithelial) thymus from normal mice are simultaneously grafted to individual adult nude mice, the host-derived T cell precursors regenerate the neonatal thymus more efficiently than the adult (reticuloepithelial) thymus. Thus, this is a direct cause for the poor restoration of the T lymphoid system of nude mice by adult and/or reticuloepithelial thymus grafts.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D006824:Hybridization, Genetic; D007111:Immunity, Cellular; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008819:Mice, Nude / Q000276:immunology*; D012038:Regeneration; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000502:physiology / Q000637:transplantation*