title: Proteins induced by infection with caliciviruses.
abstract: Three polypeptides with mol. wt. 100 (P100), 80 (P80) and 65 (P65) X 10(3) were found in calicivirus infected cells. P100 and P80 were present in sub-molar amounts compared with P65 and no precursor product relationship between the three polypeptides could be demonstrated using pulse-chase experiments or selective inhibitors of protein synthesis and of proteases. In the presence of protease inhibitors a polypeptide with mol. wt. 120 X 10(3) (P120) was demonstrated which appeared to be the precursor of P100. Possible mechanisms of translation in the caliciviruses are discussed.
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D002139:Caliciviridae / Q000378:metabolism*; D002460:Cell Line; D007460:Iodoacetamide / Q000494:pharmacology; D008970:Molecular Weight; D010142:Pactamycin / Q000494:pharmacology; D010452:Peptide Biosynthesis; D010849:Picornaviridae / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects; D011498:Protein Precursors / Q000096:biosynthesis*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013552:Swine; D014720:Vesicular Exanthema of Swine / Q000382:microbiology*; D014764:Viral Proteins / Q000096:biosynthesis*; D015032:Zinc / Q000494:pharmacology
chemical_list: D011498:Protein Precursors; D012462:Saline Solution, Hypertonic; D014764:Viral Proteins; D010142:Pactamycin; D007611:Aprotinin; D015032:Zinc; D007460:Iodoacetamide