title: [Acute lymphatic leukaemia in children: re-examination after remission of at least five years (author's transl)].
abstract: Full remission of more than five years was observed in nine of 24 children with acute lymphatic leukaemia. They had been treated by a scheme similar to the Pinkel VII one, and all had been discharged from treatment. The immune status, bone marrow, radiological, neurological and psychosomatic studies, as well as various laboratory tests indicated that in seven of the children the findings, are essentially normal. But two children have lasting severe organ damage, portal fibrosis in one and bilateral intracerebral calcification in the other, both presumably due to the methotrexate treatment.
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000139:chemically induced; D002114:Calcinosis / Q000139:chemically induced; D002648:Child; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008103:Liver Cirrhosis / Q000139:chemically induced; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D008727:Methotrexate
vernacular_title: Akute lymphatische Leukämie im Kindesalter. Nachuntersuchungen nach einer Remissionsdauer von mindestens 5 Jahren.