The evaluation of tiodonium chloride as an antiplaque and anticaries agent. II. In vitro antimicrobial activity and in vivo anticaries activity in animals.
The efficacy of tiodonium chloride as an antimicrobial, antiplaque, and anticaries agent was examined. It proved to be an effective antibacterial agent and reduced in vitro plaque formation at concentrations below its bacteriostatic level. It reduced caries in rats when used in the food at 600 microgram/gm but was not effective as a mouthrinse at up to 0.3%.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D002327:Cariostatic Agents; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000209:etiology / Q000517:prevention & control*; D004341:Drug Evaluation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009861:Onium Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D009861:Onium Compounds; D013876:Thiophenes; C020944:tiodonium chloride