title: [Multidrug chemotherapy of osteogenic sarcoma (author's transl)].
abstract: Osteogenic sarcoma may be treated effectively by radical surgical removal of the primary tumor and combined chemotherapy, including Adriamycin and high dose Methotrexate. In order to render any protocol a safe procedure, strict precautions are required to avoid drug toxicity. We present a protocol, "COSS 77", presently employed in several university hospitals of West Germany and Austria. Final results concerning long term prognosis and long term side effects are not yet available.
mesh_terms: D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy* / Q000601:surgery; D011182:Postoperative Care
chemical_list: D004317:Doxorubicin; D008727:Methotrexate
vernacular_title: Die Behandlung des Osteosarkoms--Modell einer chemotherapeutischen Strategie.