The effect of misonidazole on the radiation response of clonogenic human pancreatic carcinoma cells.
An enhancing effect of misonidazole on the in vivo radiation response of clonogenic human tumour cells from a pancreatic carcinoma xenograft has been demonstrated using both a soft agar in vitro assay and an agar in diffusion chamber assay. Enhancement ratios of 1.8 and 1.3 were found when cells were assayed at 0 h and 18 h respectively after irradiation. No enhancement was seen with in vitro irradiation of oxygenated cells. The potential of these assay systems as a perclinical screening test for new radiosensitizers is discussed.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D009593:Nitroimidazoles / Q000494:pharmacology*; D010100:Oxygen; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents; D013997:Time Factors; D014183:Transplantation, Heterologous
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D010100:Oxygen