Genetic and cellular control of spontaneous autoimmune thyroiditis in OS chickens.
B-locus genotypes have been defined in Obese strain (OS) chickens that spontaneously develop autoimmune thyroiditis (SAT), and in White Leghorn Cornell C strain (CS) chickens from which the OS was selected. The B-locus influences SAT, and some possible mechanisms are discussed. Thymic abnormalities in OS, as contrasted with CB birds, are also discussed and may play a role in SAT, as may an intrinsic defect in the thyroid gland itself.
D000818:Animals; D001327:Autoimmune Diseases / Q000662:veterinary*; D001402:B-Lymphocytes / Q000276:immunology; D005838:Genotype; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D007141:Immunoglobulin Fc Fragments; D013601:T-Lymphocytes / Q000276:immunology; D013966:Thyroiditis / Q000235:genetics / Q000276:immunology / Q000662:veterinary*
D006649:Histocompatibility Antigens; D007141:Immunoglobulin Fc Fragments