title: A pulse-radiolysis study of the reaction of hydrated electrons with N'-formylkynurenine and related compounds: electron-transfer reactions with nucleic acid components.
abstract: The reactivity of N'-formylkynurenine (FK) derivatives towards eaq has been investigated. The reduced transient species have been characterized (lambda max approximately 340, 440 nm, epsilon lambda max approximately 3000-1000 M-1 cm-1, pKa approximately 7.8). Owing to the strong FK electron affinity, electron-transfer reactions occur from purine (except guanine) and pyrimidine electron adducts to FK (k approximately 2-7 x 10(9) M-1 s-1). As some FK derivatives bind to DNA (or polynucleotides) the protective effect of complexation on FK-DNA (or polynucleotides) adduct formation has been investigated.
mesh_terms: D004247:DNA; D004579:Electron Transport; D004583:Electrons; D007737:Kynurenine / Q000031:analogs & derivatives*; D011061:Poly A; D011068:Poly G; D011675:Pulse Radiolysis; D011687:Purines; D011743:Pyrimidines; D013936:Thymidine; D013941:Thymine
chemical_list: D011687:Purines; D011743:Pyrimidines; D011061:Poly A; D011068:Poly G; D007737:Kynurenine; D004247:DNA; D013941:Thymine; D013936:Thymidine