Electrophoretically pure mouse interferon exerts multiple biologic effects.
Electrophoretically pure mouse interferon was examined for a number of biologic effects previously ascribed to crude or partially purified interferon preparations. These effects include: inhibition of the growth of a transplantable tumor in mice; inhibition of cell multiplication of mouse tumor cells in vitro; enhancement of the expression of histocompatibility antigens on mouse tumor cells in vitro; inhibition of antibody formation in vitro; inhibition of sensitization to sheep erythrocytes and the expression of delayed type hypersensitivity in mice; enhancement of natural killer cell activity in vivo and in vitro; enhancement of cell sensitivity to the toxicity of poly(I)-poly(C); and enhanced production ("priming") of interferon production in vitro. Our results establish that the molecules responsible for the antiviral action of interferon are also responsible for these varied biologic effects.
D000818:Animals; D000954:Antigens, Surface; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000503:physiopathology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D007372:Interferons / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000276:immunology / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000954:Antigens, Surface; D007372:Interferons