Protection from hyperbaric oxygen intoxication by some derivatives of alfa-ketoglutaric acid.
A study was made of the protective effects afforded by some derivatives of alpha-ketoglutaric acid in hyperbaric oxygen intoxication. The research performed shows that these substances are able either to prevent convulsions (Paul Bert phenomenon) or to prolong the survival of treated animals. Brain ATP rates and liver succinyl dehydrogenase activity, which normally decrease in hyperbaric oxygen intoxication, are also very high after protective treatment with these substances.
D000818:Animals; D001622:Betaine / Q000494:pharmacology; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010100:Oxygen / Q000037:antagonists & inhibitors / Q000633:toxicity*
D007656:Ketoglutaric Acids; D001622:Betaine; D010100:Oxygen