Unusual cytogenetics in a case of acute lymphoblastic leukemia.
The cytogenetics in the study of a patient with acute lymphoblastic leukemia are presented. Initially, a large proportion of both unstimulated and phytohemagglutinin (PHA)-stimulated blood mitoses showed an abnormal karyotype with a 7;12 translocation and a trisomy 19. At the time of relapse, a PHA-stimulated culture showed the clonal abnormality as well as dicentric chromosomes in normal cells, the latter possibly resulting from treatment.
D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000097:blood / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy