title: Some thoughts about genetics, differentiation, and malignancy.
abstract: This article deals with three related questions: (1) whether malignancy is determined by genetic or epigenetic mechanisms; (2) whether epigenetic mechanisms, as conventionally defined, actually exist; (3) what criteria are appropriate for defining dominance or recessiveness of the malignant state in cell fusion experiments.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004247:DNA / Q000235:genetics; D004260:DNA Repair; D005799:Genes, Dominant; D005808:Genes, Recessive; D005819:Genetic Markers; D006822:Hybrid Cells / Q000503:physiopathology; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype; D010957:Plasmids
chemical_list: D005819:Genetic Markers; D004247:DNA