title: E-rosette forming lymphocytes in acute leukemia before and after cell incubation with human serum thymic factor.
abstract: The Authors studied the effect of the human serum thymic factor on the peripheral blood leukocytes from ALL patients, by testing the frequency of the E+ cells by means of the E rosette assay before and after cell incubation with this factor. In four out of twenty-four patients tested, the thymic factor incubation of peripheral blood mononuclears increased the number of E+ cells. The shift from E- to E+ cells caused by the human serum thymic factor occurred among null cells (E-, SM-Ig-). The possible value of the test in investigating whether a T0 leukemia might really exists is pointed out, as well as its prospective importance in monitoring the variations of the immature T cell counts in relationship to the patient's treatment and his disease course.
mesh_terms: D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D006412:Hematopoietic Stem Cells; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D013951:Thymus Hormones / Q000494:pharmacology*
chemical_list: D013951:Thymus Hormones