Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat.
Thiocyanate was found to resemble cyanate in its inhibitory effects on [3H]thymidine incorporation and the uptake of [32P]phosphate and [3H]amino acids in transplanted tumors of the BUF rat. The capacity to inhibit metabolite uptake in hepatomas and a colon tumor under conditions in which uptake was unchanged or increased in host liver was concluded to be a common feature of the action of cyanate and thiocyanate. Inhibition of [32P]phosphate uptake and [3H]thymidine incorporation into DNA of tumors was also observed after treatment of rats with amygdalin. With this drug, however, the action on tumors and livers of host rats was similar.
D000596:Amino Acids / Q000378:metabolism; D000678:Amygdalin / Q000494:pharmacology*; D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D003485:Cyanates / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D011915:Rats, Inbred BUF; D013861:Thiocyanates / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D000596:Amino Acids; D003485:Cyanates; D010710:Phosphates; D013861:Thiocyanates; D000678:Amygdalin; D013936:Thymidine