Effects of ultraviolet light on nude mice: cutaneous carcinogenesis and possible leukemogenesis.
Squamous cell carcinomas were induced by ultraviolet irradiation in the skin of all T-cell deficient nude mice rendered sufficiently long-lived by reconstitution with syngeneic splenic or thymic cells. All homozygous hairless mice similarly exposed developed squamous cell carcinomas. Striking granulocytic proliferation was provoked in one hairless and in five reconstituted nude mice; two of the latter were interpreted as having true granulocytic leukemia.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000473:pathology; D007951:Leukemia, Myeloid / Q000209:etiology; D007953:Leukemia, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D014185:Transplantation, Isogeneic; D014466:Ultraviolet Rays / Q000009:adverse effects*