title: Pyoderma gangrenosum and myeloproliferative disorders. Report of a case and review of the literature.
abstract: The exact mechanism involved in the pathogenesis of pyoderma gangrenosum (PG) still remains unclear, yet there is an increasing number of reports associating PG with immunologic abnormalities. A correlation between PG and myeloproliferative disorders has also been described. We describe a patient with chronic myelocytic leukemia in whom PG developed during the course of illness. We present an immunologic analysis of this case, speculation on the pathogenesis of PG, and a review of the literature. We report the futility of current therapeutic modalities in the treatment of PG.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007951:Leukemia, Myeloid / Q000150:complications*; D011711:Pyoderma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology