Phytomitogen-induced, lymphokine-mediated cartilage proteoglycan degradation.
The significance of T-cell activation in the immunopathogenesis of articular disease has been studied in an in vitro model to assess the capacity of phytomitogen-induced lymphokines to degrade cartilage matrix proteoglycans. Supernatants derived from T-cell activation of normal human peripheral blood lymphocytes were shown to contain a monocyte-dependent, serum-inhibitable, dialyzable factor or factors capable of inducing significant proteoglycan degradation, as assessed by release of macroprecipitable 35S-labeled proteoglycan from heterologous cartilage substrates.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D002356:Cartilage / Q000276:immunology*; D002417:Cattle; D004306:Dose-Response Relationship, Immunologic; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D037102:Lectins / Q000276:immunology; D008222:Lymphokines / Q000276:immunology*; D008954:Models, Biological; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*
D037102:Lectins; D008222:Lymphokines; D011509:Proteoglycans