[Small-nodular liver cirrhosis with marked portal hypertension due to vitamin A intoxication resulting from psoriasis treatment (author's transl)].
Clinical and histological signs of small nodular liver cirrhosis with portal hypertension were present in a 36-year-old man, three-and-a-half years after a seven-week course of treatment of psoriasis vulgaris with high doses of vitamin a (70 X 10(6) IU orally). Although there is no increase in serum level of vitamin A now, increased deposits of vitamin A in the perisinusoidal lipid storage cells (Ito cells) are still demonstrated by fluorescencespectrophotometry and under the electron microscope. Fundectomy with resection of the terminal oesophagus was necessary because of bleeding from oesophageal varices.
D000328:Adult; D004932:Esophageal and Gastric Varices / Q000150:complications; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008099:Liver / Q000032:analysis; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000150:complications; D008297:Male; D011565:Psoriasis / Q000188:drug therapy*; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis / Q000627:therapeutic use
D014801:Vitamin A
Kleinknotige Leberzirrhose mit ausgeprägter portaler Hypertension als Folge einer Vitamin-A-intoxikation bei Psoriasis-Behandlung.