Mental symptoms and electrolyte imbalance.
A 75-year-old woman on long term diuretic therapy presented with depression. She was found to have hyponatraemia and hypochloraemia. There was no improvement in her condition with antidepressant medication but she responded promptly to cessation of spironolactone and prescription of potassium chloride.
D000368:Aged; D002713:Chlorine / Q000097:blood; D003072:Cognition Disorders / Q000139:chemically induced*; D003221:Confusion / Q000139:chemically induced*; D003863:Depression / Q000139:chemically induced*; D004232:Diuretics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D013148:Spironolactone / Q000009:adverse effects; D013997:Time Factors; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
D004232:Diuretics; D013148:Spironolactone; D002713:Chlorine