Acute lymphoblastic leukemia followed by chronic myelocytic leukemia.
Second hematologic malignancies occur rarely in patients previously treated for leukemia. This report describes a patient with acute lymphoblastic leukemia who remained in complete remission for 5 yr and then developed chronic myelocytic leukemia (CML). The original lymphoblasts were associated with a partial deletion of chromosome 21, while CML was associated with a classic Philadelphia marker, indicating the independent origin of the two leukemias.
D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000235:genetics; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000235:genetics; D014178:Translocation, Genetic