title: Microscarring in skeletal muscle after repeated exposures to lidocaine with epinephrine.
abstract: To assess the effect of repeated exposures to clinically used local anesthetic, rat thighs were given up to five supramuscular injections of 2% lidocaine with epinephrine, 1:50,000. Substantial damage to muscles followed by rapid regeneration occurred; however, in some areas evidence of retarded regeneration of muscles and microscarring was observed.
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000494:pharmacology; D007279:Injections, Subcutaneous; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects; D008619:Mepivacaine / Q000008:administration & dosage / Q000009:adverse effects; D009132:Muscles / Q000187:drug effects; D011318:Prilocaine / Q000008:administration & dosage / Q000009:adverse effects; D051381:Rats; D012038:Regeneration
chemical_list: D000779:Anesthetics, Local; D011318:Prilocaine; D008012:Lidocaine; D008619:Mepivacaine; D002045:Bupivacaine; D004837:Epinephrine