Immunoblastic lymphadenopathy. A mixed proliferation of T and B lymphocytes.
A case of typical immunoblastic lymphadenopathy is described. Cell surface marker studies were performed on mononuclear isolates from peripheral blood, ascitic fluid and a lymph node biopsy and the results correlated with light microscopic findings. These data indicated that the majority of the cells in the lymph node were of T cell origin. A smaller percentage of cells could be recognized as deriving from the B cell line and it may have contained a monoclonal subpopulation. Some immunoblasts formed E rosettes and could be identified as T cells but most did not form E or EAC rosettes or bear SmIg and could not be identified as B cells. There was an associated marked increase in mononuclear phagocytes in both ascites and peripheral blood. This disease entity may represent a dual proliferation of cells originating from both B and T cell compartments with T cells predominating in the lymph node in this case.
D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology*; D002455:Cell Division; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000276:immunology / Q000473:pathology*; D008297:Male; D009000:Monocytes / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*