A closed inhalation system for pharmacokinetic and metabolism studies of volatile compounds with small laboratory animals.
In the inhalation system described an animal can be kept in the same atmosphere of a 2-liter desiccator for up to 24 h. The expired carbon dioxide is adsorbed with soda lime and the resulting reduced pressure is balanced by a supply of oxygen also used for the inflow of the chemical to be investigated. Urine and faeces can be collected separately and the system allows a periodical control of the concentration of the chemical by sampling the air with needle and syringe.
D000818:Animals; D004780:Environment, Controlled; D006813:Humidity; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010600:Pharmacology / Q000295:instrumentation*; D013696:Temperature; D013997:Time Factors; D014835:Volatilization
D004364:Pharmaceutical Preparations