title: Nitropyrrole radiosensitizers: structure function relationships.
abstract: Nitropyrrole derivatives have been tested as hypoxic cell radiosensitizers in vitro and in vivo. Radiosensitizing potential generally increases with nitropyrrole electron affinity. N-hydroxyethyl substitution decreases toxicity relative to N--CH3, N--CH2 CH3 and N--CH2 CH2 CH3 substitution. The most effective nitropyrrole tested in vivo is N-hydroxyethyl-2-cyano-5-nitropyrrole (NP-1).
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D066298:In Vitro Techniques; D051379:Mice; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D010101:Oxygen Consumption / Q000187:drug effects; D011758:Pyrroles / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents; D013329:Structure-Activity Relationship
chemical_list: D011758:Pyrroles; D011838:Radiation-Sensitizing Agents