Misonidazole with small dose fractions in an experimental osteosarcoma.
The mouse osteosarcoma C22LR was irradiated with a single X-ray dose of 1000 or 1500 rad (to prevent rapid growth) and then with fractionated doses of 300 or 600 rad each. Half the mice were given 0.8 mg/g of misonidazole 1 h before irradiation. Tumour growth delay was determined. The radiosensitizer did enhance the effect of small (300 rad) doses per fraction, as well as that of 600 rad doses.
D000818:Animals; D051379:Mice; D009593:Nitroimidazoles / Q000494:pharmacology*; D012516:Osteosarcoma / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage; D012513:Sarcoma, Experimental / Q000532:radiotherapy
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents