Different time course of development for high-affinity choline uptake and choline acetyltransferase in the chick retina.
Synthesis and storage of [3H]acetylcholine in isolated pieces of chick retina increased in two stages during embryogenesis. The first increase coincided with a 100-fold rise in the activity of choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), but during the second increase the activity of this enzyme remained essentially constant. The second increase instead was linked to an approximately 6-fold increase in the Vmax for high-affinity uptake of choline.
D000818:Animals; D001692:Biological Transport; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D002642:Chick Embryo; D002645:Chickens; D002794:Choline / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000196:embryology / Q000254:growth & development; D006426:Hemicholinium 3 / Q000494:pharmacology; D007700:Kinetics; D012160:Retina / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism
D006426:Hemicholinium 3; D002795:Choline O-Acetyltransferase; D002332:Carnitine O-Acetyltransferase; D002794:Choline