[Influencing of the kininogen-Kinin-System by means of a kallikrein-inhibitor during extracorporeal circulation in open heart surgery (author's transl)].
During extracorporeal circulation for open heart surgery an activation of the kininogen-kininsystem occurs with a decrease in plasma-kininogen-levels significantly exceeding the effect of haemodilution, and thus being due to an increased liberation of kinin. This effect could be suppressed by kallikrein inhibition by means of a protease-inhibitor.
D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000494:pharmacology*; D001920:Bradykinin / Q000097:blood; D001026:Coronary Artery Bypass / Q000379:methods; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000601:surgery*; D006801:Humans; D007704:Kininogens / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007704:Kininogens; D007705:Kinins; D007611:Aprotinin; D001920:Bradykinin
Beeinflussung des Kininogen-Kininsystems durch einen Kallikreinhemmer bei Operationen am offenen Herzen in extracorporaler Zirkulation.