Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones.
In the isolated frog or rat spinal cord, low concentrations of Mg2+ (0.5-1.00 mM) markedly depress, in a substantially Ca2+-independent manner, ventral root depolarizations produced by dorsal root stimulation and by certain amino acids (e.g. N-methyl-D-aspartate and L-homocysteate) but do not depress depolarizations produced by other excitatory amino acids (e.g. kainate and quisqualate). L-Aspartate-induced depolarizations are more sensitive to Mg2+ then are L-glutamate-induced depolarizations.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D008274:Magnesium / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011894:Rana pipiens; D011896:Rana temporaria; D051381:Rats; D013045:Species Specificity; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D000596:Amino Acids; D008274:Magnesium