Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent.
NK cells with lytic capacity for Moloney leukemia virus-induced lymphomas have previously been found to occur spontaneously in spleens from nonimmune adult mice. Here, 89Sr-treatment is shown to suppress NK cell function in adult mice without similarly affecting other cell-mediated immune reactions. Thus, selective 89Sr-sensitivity distinguishes NK cells from other killer cell types. The present results indicate that in vivo a functional bone marrow is needed for generation and maintenance of NK activity.
D000818:Animals; D000951:Antigens, Neoplasm; D001402:B-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007111:Immunity, Cellular / Q000528:radiation effects*; D008223:Lymphoma / Q000209:etiology / Q000276:immunology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008979:Moloney murine leukemia virus; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology; D013154:Spleen / Q000276:immunology / Q000528:radiation effects*; D013326:Strontium Radioisotopes / Q000009:adverse effects; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
D000951:Antigens, Neoplasm; D013326:Strontium Radioisotopes