Immunologic reactivity of lymph nodes regional to prostatic cancer: preliminary observations.
Regional pelvic lymph nodes from 9 patients with prostatic carcinoma were investigated for in vitro immunologic reactivity to T and B cell mitogens. Regional lymph node lymphocytes were significantly more reactive when obtained from nodes morphologically displaying T and B lymphocyte hyperplasia than from nodes that histologically appeared normal or depleted the lymphocytes. The data suggest that a morphologic evaluation of lymph nodes regional to prostate cancer may reflect the patient's antitumor immune response.
D000230:Adenocarcinoma / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D010388:Pelvis; D011471:Prostatic Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D008934:Mitogens