[Role of H-2 region in cytolysis of viral induced lymphomas by T lymphocytes].
The cytolyse of lymphoma cells by anti-MSV-CTL requires an H-2 identity on CTL and target cells. It can be limited to D or K antigens. An altered cells hypothesis is the more likely hypothesis in H-2a or H-2d tumour cells. However the D antigen alone is involved in H-2b tumours Arguments are given which supports the existence of Ir genes controlling the formation of CTL against H-2Dd modified by MSV.
D000818:Animals; D003588:Cytopathogenic Effect, Viral; D003601:Cytotoxicity Tests, Immunologic; D006649:Histocompatibility Antigens; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008979:Moloney murine leukemia virus; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens
Rôle de la Région H-2 dans la cytolyse par des lymphocytes T de cellules de lymphomes viro-induits