[Comparison of the immunodepressant effect of antimacrophage, antilymphocyte and antithymocyte sera following immunization with influenza virus A2].
An immunodepressive action of the anticellular sera was cause by the competition of the serum and viral antigens, as well as by the specific influence of the sera on the corresponding cells. The antimacrophagal serum decreased the monocyte content in the peripheral blood, peritoneal exudate, and retarded the antibody formation in the lymphoid organs. The antilymphocytic serum depressed the development of the plasma cell reaction in the lymph nodes and the spleen, this being expressed in a depression of the increase of the serum antihemagglutinin titre. The antithymocytic serum shortened the period of the active antibody formation.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000961:Antilymphocyte Serum / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination
D000914:Antibodies, Viral; D000961:Antilymphocyte Serum; D007106:Immune Sera; D007166:Immunosuppressive Agents; D007252:Influenza Vaccines
Sravnenie immunodepressivnogo deĭstviia antimakrofagal'noĭ, antilimfotsitarnoĭ i antitimotsitarnoĭ syvorotok pri immunizatsii virusom grippa A2