[Correlation of heredity and environmental factors in the etiology of Vilyui encephalomyelitis. II. A population genetic study in districts of Vilyui encephalomyelitis distribution].
Population-genetic investigation was carried out in the regions endemic for Viljuisk encephalomyelitis (VE). The following indices were estimated: the relationship coefficient, the inbreeding coefficient, the intensity of migration, genetic structure of the population. The aim of the investigation was to explain causes of intrapopulational and, in some cases, of intragenus accumulation of the VE patients. No evidence of isolation or increased inbreeding were found in highly affected populations. The genetic structure of a group of VE patients tested for 9 polymorphic systems did not reveal any deviation from the control group. Several VE cases in healthy populations occured in some years after the immigration of a VE patient. These data confirm the hypothesis that VE is transmitted from a VE patient to healthy persons. Among these persons fall ill those who have a hereditary determined increased sensitivity to VE which results in intrapopulation and intragenus accumulation of VE cases.
D000328:Adult; D001110:Arctic Regions; D003241:Consanguinity; D004641:Emigration and Immigration; D004679:Encephalomyelitis / Q000453:epidemiology / Q000235:genetics*; D004782:Environmental Health; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D008297:Male; D010375:Pedigree; D012424:Rural Population; D012800:Siberia
D005819:Genetic Markers
Sootnoshenie nasledstvennosti i sredovykh faktorov v étiologii viliuĭskogo éntsefalomielita. Soobshchenie II. Populiatsionno-geneticheskoe issledovanie v raĭonakh rasprostraneniia viliuĭskogo éntsefalomielita.