title: The association of haemopoietic dysplasia (pre-leukaemia) and abnormal cell clone with connective tissue disease.
abstract: A 68-year-old man with haemotological features consistent with haemopoietic dysplasia (pre-leukaemia) and an abnormal cell clone in the marrow, 46, XY, -18, +t(13;18) (q11;123), developed acute connective tissue disease characterised by vasculitis, dermal changes, marked muscular weakness and serological features suggesting an auto-immune disturbance. Although four other cases of haemopoietic dysplasia ("pre-leukaemia") with unusual connective tissue disease had been reported since the recognition of haemopoietic dysplasia as a distinct entity, a definite association between these two disease states still awaits confirmation by further reports and investigations.
mesh_terms: D000368:Aged; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D003095:Collagen Diseases / Q000150:complications* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male; D011289:Preleukemia / Q000150:complications* / Q000235:genetics; D012867:Skin / Q000473:pathology; D014178:Translocation, Genetic; D014657:Vasculitis / Q000150:complications / Q000235:genetics