Plasma radioiron kinetics in man: explanation for the effect of plasma iron concentration.
The plasma iron turnover was measured in 19 normal subjects. A correlation was found between plasma iron concentration and plasma iron turnover. In addition to the turnover of 55Fe at normal plasma iron concentration (predominantly monoferric transferrin), a second turnover in which the labeled plasma was saturated with iron (to produce predominantly diferric transferrin) was studied with 50Fe. It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged. It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.
D000328:Adult; D001810:Blood Volume; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D007504:Iron Radioisotopes; D007700:Kinetics; D008297:Male; D014168:Transferrin / Q000378:metabolism*
D007504:Iron Radioisotopes; D014168:Transferrin; D007501:Iron