The efficacy of amidantel, a new anthelmintic, on hookworms and ascarids in dogs.
Amidantel is a new anthelmintic from a new chemical class with an interesting anthelmintic spectrum. In dogs amidantel is highly effective in a single oral dose of 25 mg/kg against both hookworm species, Ancylostoma caninum and Unicinaria stenocephala. In Toxascaris leonina infected dogs a complete cure rate was achieved with a single oral dose of 50 mg/kg. Similar results were obtained with 8 mg/kg administered three times per day. The most sensitive parasite to amidantel was found to be Toxocara canis  with a 100 per cent cure rate after a single oral treatment with 10 mg/kg. In preliminary trials amidantel was also effective against hookworms and ascarids after subcutaneous administration. All hookworms and almost all of the ascarids were eliminated with the faeces within 2 days after treatment. Amidantel was tolerated in all dosages tested by all the dogs without any symptoms.
D000722:Ancylostoma / Q000187:drug effects; D000723:Ancylostomatoidea / Q000187:drug effects; D000724:Ancylostomiasis / Q000188:drug therapy; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005243:Feces / Q000469:parasitology; D006373:Helminthiasis / Q000188:drug therapy*; D006376:Helminths / Q000187:drug effects*; D006725:Hookworm Infections / Q000188:drug therapy; D009349:Nematode Infections / Q000188:drug therapy; D010655:Phenylenediamines / Q000494:pharmacology / Q000627:therapeutic use*; D014114:Toxascaris / Q000187:drug effects; D014119:Toxocara / Q000187:drug effects; D014120:Toxocariasis / Q000188:drug therapy
D000871:Anthelmintics; D010655:Phenylenediamines; C019144:amidantel