Protection against anaphylaxis in hymenoptera-sensitive patients by passive immunization.
Passive administration of specific immunoglobulin led to a transient rise in antiphospholipase IgG. An observed rise of 2 microgram/ml (twofold in three cases) was associated with a very diminished response to bee venom. This did not prevent the patient's own IgG response to challenge, which was at least as good as that of non-infused patients. The infusion of IgG cannot be proposed at present as a routine mode of therapy in insect allergy. However, we present the results of our study as the best evidence to date that blocking antibody is protective.
D000707:Anaphylaxis / Q000517:prevention & control*; D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D001514:Bee Venoms / Q000276:immunology; D001667:Binding, Competitive; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D006927:Hymenoptera / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000096:biosynthesis; D007275:Injections, Intravenous; D007299:Insect Bites and Stings / Q000276:immunology*
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D001514:Bee Venoms; D007074:Immunoglobulin G; D007073:Immunoglobulin E