[Aseptic necrosis of the femoral head in lymphogranulomatosis and chronic myeloic leukemia treated intermittently with cytostatic agents and steroids (author's transl)].
Four male patients with the age from 31--43 years with lymphogranulomatosis and a 23 year old patient with chronic myeloic leukemia developed aseptic necrosis of the femoral head 15 to 69 months after treatment with a combination of cytostatic substances and steroids. In a patient who received maximal prednisone applications aseptic necrosis of the humeral head has been observed also. With increasing life expectancy asceptic bone necrosis due to treatment can appear as a late complication. The early recognition is important. The advancing of this irreversible bone destruction and the associated morbidity can be avoided by immediate cessation of the steroid application. Conservative treatment is indicated.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D006811:Humerus; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008297:Male; D010020:Osteonecrosis / Q000139:chemically induced; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography
D000970:Antineoplastic Agents; D011241:Prednisone
Aseptische Hüftkopfnekrosen bei Lymphogranulomatose und chronisch-myeloischer Leukämie unter intermittierender Steroid-und Cytostatica-Therapie.