Pyridoxal phosphate catalyzed alpha-beta elimination of selenahomolysine.
In the presence of pyridoxal phosphate selenahomolysine undergoes alpha-beta elimination with production of pyruvate, ammonia and selenohomocysteamine. If the reaction occurs in anaerobic conditions the coupling of pyridoxal phosphate with selenohomocysteamine in a tetrahydro-selenazine ring may be detected by the appearance of an absorption band at 320 nm. In the presence of air the autoxidation rate of selenohomocysteamine is too high to allow the detection of the selenazine derivative. The results obtained add to the previously reported ones indicating that selenium- and sulfur-containing aminoacids react in quite the same way in the non enzymic model studied.
D002384:Catalysis; D008239:Lysine / Q000031:analogs & derivatives*; D016566:Organoselenium Compounds; D011732:Pyridoxal Phosphate; D012643:Selenium
D016566:Organoselenium Compounds; D011732:Pyridoxal Phosphate; C017711:selenohomolysine; D012643:Selenium; D008239:Lysine