The protective effect of cimetidine on stress-induced acute gastric ulceration in the rat.
The effect of intraperitoneal cimetidine, an H2 receptorantagonist, has been assessed on the development of cold-restraint induced acute gastric ulcers in rats. Cimetidine in doses ranging from 20-100 mg per kg body weight significantly reduced the incidence of acute gastric ulceration compared with saline controls in this model. The protective effect of cimetidine suggests a prophylactic role for this agent in stress-induced gastric or duodenal ulceration in man.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D003080:Cold Temperature; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D006146:Guanidines; D002927:Cimetidine