Cell-mediated responses in dogs with spontaneous neoplasms. II. Detection by direct leukocyte migration inhibition technique.
A series of 39 dogs bearing spontaneous mammary carcinomas or melanomas were tested for tumor-directed immune response against allogeneic Formalin-treated tumor cells. The immune response was assessed by the direct leukocyte migration inhibition technique. Comparison of leukocytes from tumor bearers and healthy donors by chi-square analysis showed no statistical difference between the groups. The findings did not provide evidence for the existence of specific tumor antigens in the dog.
D000818:Animals; D000951:Antigens, Neoplasm; D002464:Cell Migration Inhibition; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D005260:Female; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008321:Mammary Glands, Animal; D008545:Melanoma / Q000276:immunology / Q000662:veterinary*; D009369:Neoplasms / Q000276:immunology / Q000662:veterinary*
D000951:Antigens, Neoplasm