T lymphocytes and the transfer of immunity to Trypanosoma musculi in mice.
Trypanosoma musculi produces a resolving infection in mice and the immune response is thymus dependent. Spleen cells from immune and from uninfected mice were transferred to T cell-deprived mice and restored their ability to control the infection, the immune cells being effective most rapidly. Treatment of the cells in vitro with anti-theta serum did not impair their ability to restore immunocompetence and it is proposed that, though T-cell dependent, the immune response is effected by theta- cells.
D000818:Animals; D007111:Immunity, Cellular; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013934:Thymectomy; D014345:Trypanosoma / Q000472:pathogenicity; D014352:Trypanosomiasis / Q000276:immunology*