Tolerizing effect of DNP-ficoll on IgE antibody production.
A/J and DBA/1 mice were infected with 750 third-stage larvae of Nippostrongylus brasiliensis and immunized with 1 mug dinitrophenylated N. brasiliensis extract (DNP-Nb) with 1 mg Al(OH)3 to produce high titers of anti-hapten IgG1 and IgE antibody. Partial tolerance to the production of anti-hapten IgG1 and IgE antibody could be induced by DNP-Ficoll from 5 weeks before to 1 week after the DNP-Nb immunization. The tolerized state persisted through the duration of the experiments. However, no tolerizing effect could be demonstrated on secondary antihapten IgE antibody production induced by DNP-Nb. Moreover, DNP-Ficoll failed to evoke anti-hapten IgG1 or IgE antibody production.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D005362:Ficoll / Q000494:pharmacology*; D006725:Hookworm Infections / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects*; D007115:Immunization Schedule; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009559:Nippostrongylus / Q000276:immunology; D009578:Nitrobenzenes / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats
D004136:Dinitrobenzenes; D007074:Immunoglobulin G; D009578:Nitrobenzenes; D011134:Polysaccharides; D005362:Ficoll; D007073:Immunoglobulin E