[Emergency treatment of haemophilia A with factor VIII inhibitors using activated prothrombin complex concentrates (author's transl)].
Severe rectal bleeding in a 6-year-old boy with haemophilia A and factor VIII inhibitors could not be stopped with factor VIII concentrates. But a good effect was achieved with activated prothrombin complex concentrates (fraction FEIBA), given over eight days. Amaurosis occurred as a complication after injection of the first dose, but disappeared completely within several minutes. Tests revealed accelerated intravascular coagulation with increased fibrin monomers and fibrin/fibrinogen degradation products.
D001766:Blindness / Q000150:complications; D002648:Child; D004630:Emergencies; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000188:drug therapy; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011516:Prothrombin / Q000627:therapeutic use*
D011516:Prothrombin
Notfallbehandlung von Blutungskomplikationen bei Hemmkörper-Hämophilie mit aktivierten Prothrombinkomplex-Konzentraten