The use of mixtures of octapressin and adrenaline in local anaesthetic solutions to obtain more effective vasoconstriction.
The synergistic effects of felypressin with adrenaline have been studied using the isolated central artery of the rabbit ear as a vascular model. Sub-constrictor doses of felypressin were shown to increase adrenaline's vasoconstrictor effect on this vessel. It is therefore suggested that a mixture of felypressin and adrenaline be used in local anaesthetic solutions in order to provide more effective vasoconstriction.
D000779:Anesthetics, Local; D000818:Animals; D004338:Drug Combinations; D004357:Drug Synergism; D004431:Ear, External / Q000098:blood supply*; D004837:Epinephrine / Q000494:pharmacology*; D005259:Felypressin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008012:Lidocaine; D008236:Lypressin / Q000494:pharmacology*; D011318:Prilocaine; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects*
D000779:Anesthetics, Local; D004338:Drug Combinations; D011318:Prilocaine; D008236:Lypressin; D005259:Felypressin; D008012:Lidocaine; D004837:Epinephrine