title: Osteogenic sarcoma complicating osteogenesis imperfecta tarda.
abstract: We describe the case history of a 13 years old boy who developed osteogenic sarcoma of the left thigh, six years after diagnosis of osteogenesis imperfecta tarda with a positive family history. Only four other patients with this disease combination are reported in the literature. Preoperative treatment with high-dose Methotrexate caused marked tumor regression, as shown at examination of amputation material. The inter-relationships between the two disorders are discussed and the literature is briefly reviewed.
mesh_terms: D000293:Adolescent; D000671:Amputation, Surgical; D005266:Femoral Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010013:Osteogenesis Imperfecta / Q000150:complications*; D012516:Osteosarcoma / Q000150:complications* / Q000188:drug therapy / Q000601:surgery
chemical_list: D008727:Methotrexate