title: Polyene antibiotics. IX. An improved method for the preparation of methyl esters of polyene antibiotics.
abstract: An improved general method for the preparation of methyl esters of polyene antibiotics is discussed. Using this method methyl esters of pimaricin, nystatin, eurocidin, hamycin, hamycins A and B, aureofungin, partricins A and B, candimycin, candicidin, and amphotericin B have been prepared and their physical properties are reported. The biological activities of hamycins A and B and their methyl esters are also described.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004951:Esterification; D004952:Esters; D056890:Eukaryota / Q000187:drug effects; D008722:Methods; D010866:Natamycin / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004952:Esters; D011090:Polyenes; D010866:Natamycin