HLA-D associated alloantisera react with molecules similar to Ia antigens.
Two human alloantisera specific to bone marrow-derived lymphocytes (B cells) were shown to precipitate polypeptide chains of 29,000 and 34,000 daltons from human lymphoblastoid B cell lines. These molecules are similar to murine Ia antigens and are also precipitated by a rabbit B-cell specific heteroantiserum. Since the alloantisera are thought to recognize determinants coded by HLA-D or closely linked loci, these data support the hypothesis that these B-cell specific alloantigens are the human counterpart of the mouse Ia antigens and may be the products of HLA-D.
D001402:B-Lymphocytes / Q000276:immunology; D002460:Cell Line; D005260:Female; D005815:Genetic Code; D006680:HLA Antigens; D006801:Humans; D007106:Immune Sera; D007518:Isoantibodies; D008970:Molecular Weight
D006680:HLA Antigens; D007106:Immune Sera; D007518:Isoantibodies