Central nervous system involvement in SLE. Diagnostic profile and clinical features.
The clinical course and diagnostic profile of 13 patients with central nervous system involvement and systemic lupus erythematosus (CNS-SLE) are presented. The diagnostic yield for each procedure was measured as the precent abnormal: CSF total protein was 38%; increased CSF IgG 69%; decreased CSF hemolytic C4 10%; increased CSF anti-DNA 64%; electroencephalogram 80%; flow brain scan 50%; and static brain scan 0%. No single procedure was consistently abnormal, but the battery of tests provided a useful and specific CNS-SLE diagnostic profile.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000134:cerebrospinal fluid; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003181:Complement C4 / Q000134:cerebrospinal fluid; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D013667:Technetium
D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D002556:Cerebrospinal Fluid Proteins; D003181:Complement C4; D007074:Immunoglobulin G; D013667:Technetium