Treatment of fatal disseminated vaccinia virus infection in immunosuppressed mice.
Studies were performed to compare the therapeutic effectiveness of three antiviral drugs (ARA-A, ARA-C and IDU) on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. Treatment with ARA-A begun as late as 7 days after virus infection was significantly effective in preventing death; no antiviral effect of the other two drugs was demonstrated.
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007065:Idoxuridine / Q000008:administration & dosage / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D007274:Injections, Intraperitoneal; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014615:Vaccinia / Q000188:drug therapy* / Q000401:mortality; D014740:Vidarabine / Q000008:administration & dosage / Q000627:therapeutic use*
D000961:Antilymphocyte Serum; D003561:Cytarabine; D014740:Vidarabine; D007065:Idoxuridine