title: Characterization of human adenoid cells using surface and functional markers for lymphocyte subpopulations.
abstract: Adenoid lymphocytes from children undergoing adenoidectomy were compared with blood cells from the same children using techniques for identifying T cells and B cells. A high proportion of adenoid lymphocytes were immunoglobulin positive cells. Of these only a minor fraction carried receptors for the Fc part of IgG. Adenoid B lymphocytes respond poorly if at all to polyclonal B-cell activators, such as LPS or PPD, which show a different reactivity compared to human splenic cells. The response to anti B2-microglobulin was also different; blood cells responded better than adenoid cells. Thus distinct subpopulations of B lymphocytes reside in different lymphoid organs. The adenoid lymphocyte reactivity might reflect their function in the defence mechanism against infections.
mesh_terms: D000234:Adenoids / Q000166:cytology* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003183:Complement C6; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D003183:Complement C6; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D011947:Receptors, Antigen, B-Cell; D004247:DNA