Classical conditioning of hippocampal theta patterns in the rat.
Electrical stimulation (88 HZ) of the lateral hypothalamus elicited a sustained theta response at hippocampal recording sites of rats immobilized with succinylcholine. By pairing this unconditioned stimulus with a 10-sec presentation of a light, conditioned theta responses were demonstrated in as few as 40 trials. Spectral analysis of hippocampal bioelectric patterns during acquisition, extinction, and reconditioning indicated that the earliest change as a result of conditioning is a loss of power in EEG frequency below 8 HZ, followed by the development of a peak at 8 HZ with further conditioning. Extinction was associated with an increase in power in the frequencies below 8 HZ. When the conditioned rats were tested in the absence of the neuromuscular blocking agent, the conditioned stimulus elicited a theta response that was associated with slow motor activity on 70% of the trials.
D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D004558:Electric Stimulation; D004569:Electroencephalography; D005108:Extinction, Psychological / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology; D007103:Immobilization / Q000187:drug effects; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009068:Movement; D010775:Photic Stimulation; D051381:Rats; D013390:Succinylcholine / Q000494:pharmacology; D013826:Theta Rhythm
D013390:Succinylcholine