Agammaglobulinemia with arthritis and celiac disease developing after infectious mononucleosis. Follow-up study of a case.
A previously healthy 2 1/2-year-old boy from a healthy family developed agammaglobulinemia with arthritis 3 months after infectious mononucleosis (IM). The response of serum immunoglobulins at the initial stage of IM was typical, with greatly elevated IgM and a positive IM-specific heterophil antibody test. A secondary celiac disease was diagnosed one year after IM. Considering the serum immunoglobulin levels and the normal half-lives of IgM and IgG, it seems very probable that the synthesis of immunoglobulins ceased about one month after the onset of IM. The role of suppresor T-cells in the development of acquired secondary agammaglobulinemia is discussed.
D000361:Agammaglobulinemia / Q000209:etiology*; D001170:Arthritis, Infectious / Q000209:etiology*; D002446:Celiac Disease / Q000209:etiology*; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007244:Infectious Mononucleosis / Q000150:complications*; D007583:Jejunum / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D007136:Immunoglobulins