Dynamics of folded proteins.
The dynamics of a folded globular protein (bovine pancreatic trypsin inhibitor) have been studied by solving the equations of motion for the atoms with an empirical potential energy function. The results provide the magnitude, correlations and decay of fluctuations about the average structure. These suggest that the protein interior is fluid-like in that the local atom motions have a diffusional character.
D007611:Aprotinin; D055592:Biophysical Phenomena; D001703:Biophysics; D005583:Fourier Analysis; D008958:Models, Molecular; D009038:Motion; D011487:Protein Conformation; D011506:Proteins; D012997:Solvents; D013816:Thermodynamics; D013997:Time Factors; D014961:X-Ray Diffraction
D011506:Proteins; D012997:Solvents; D007611:Aprotinin