On the function of cilia in the female reproductive tract.
A recently discovered syndrome is characterized by congenital immotility of the cilia. It consists of chronic infections in the respiratory system, male infertility, and, in about one-half of the cases, situs inversus. The syndrome thus includes Kartagener's syndrome. The syndrome provides a unique opportunity to gain insight into the role of the cilia in the human body. Five women evidently suffering from this syndrome were examined. They had no gynecologic disorders. Three of the five women had tried to become pregnant and two have suceeded. A review of the literature indicates that men with Kartagener's syndrome are usually infertile, whereas the women are not. This fact and the data presented herein constitute strong evidence that ciliary motility is not essential for female fertility. More conclusive proof could be obtained if any of the affected women would consent to ultrastructural investigation of the oviductal cilia.
D000293:Adolescent; D000328:Adult; D002923:Cilia / Q000502:physiology*; D005260:Female; D005836:Genitalia, Female / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology; D007619:Kartagener Syndrome / Q000503:physiopathology; D009068:Movement; D011247:Pregnancy; D013577:Syndrome