In vitro testing of plaque control agents.
The development of a number of in vitro techniques for the evaluation of antiplaque effects of test agents has followed the characterization and culturing of plaque-forming microorganisms. Studies of the mechanism of action of chlorhexidine and clinical observations have assisted in defining critical aspects of these in vitro techniques. Such assays may play an increasingly important role in screening potential new agents as well as in the optimization of properties by chemical modification of new lead agents. In addition, data generated in the in vitro assay may assist the design of in vivo evaluations of new agents. Proper selection of in vitro techniques for these various functions in the pre-clinical development process may reduce the time and cost involved in the development of new antiplaque agents.
D000190:Actinomyces / Q000166:cytology; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002710:Chlorhexidine / Q000494:pharmacology; D003743:Dental Enamel / Q000648:ultrastructure; D003773:Dental Plaque / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations; D010600:Pharmacology; D013295:Streptococcus mutans / Q000166:cytology
D000891:Anti-Infective Agents, Local; D004364:Pharmaceutical Preparations; D002710:Chlorhexidine