Resistance of G mice to murine leukemia virus infection: apparent disparity in in vivo and in vitro resistances.
We observed a marked discordance between in vivo and in vitro sensitivities to Friend murine leukemia virus in G mice. In vivo resistance of G mice was more than 10(5)-fold relative to sensitive DDD mice, whereas in vitro resistance was only 50 to 100-fold. In vivo sensitivity to N- and NB-tropic Friend murine leukemia virus was recessive in (G X DDD)F1 mice, whereas in vitro sensitivity was dominant in the heterozygotes. The resistance of mouse fibroblasts was different from the resistance of fibroblasts of a certain NZB mouse strain.
D000818:Animals; D005622:Friend murine leukemia virus; D005796:Genes; D005808:Genes, Recessive; D006824:Hybridization, Genetic; D066298:In Vitro Techniques; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008814:Mice, Inbred NZB; D014412:Tumor Virus Infections / Q000235:genetics