title: Effects of murine erythroleukemia inducers on mouse erythroid colony formation in culture.
abstract: The effect of various agents which are known to increase the differentiation of Friend erythroleukemia cells was investigated in cultures of mouse bone marrow cells. N,N-dimethylacetamide (5 and 15 mM) and acetamide (60 mM) significantly increased the number of erythroid colonies observed. Tetramethylurea, dimethylformamide, pyridine N-oxide, and butyric acid were ineffective. Dimethylsulfoxide at a concentration of 1% significantly increased colony number in cultures of marrow cells obtained from male mice, but had no effect in cultures of female bone marrow cells.
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D014412:Tumor Virus Infections / Q000188:drug therapy
chemical_list: D000081:Acetamides; D004921:Erythropoietin; D004121:Dimethyl Sulfoxide