The treatment of advanced histiocytosis-X with sequential hemibody irradiation.
A patient with systemic histiocytosis was treated with hemibody irradiation, vincristine, and prednisone. The patient died of an extensive peripheral neuropathy. An autopsy revealed gross histiocytosis-X involvement of the unirradiated tissues, and no evidence of disease within the field of irradiation. A treatment protocol employing sequential hemibody irradiation is discussed.
D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000009:adverse effects / Q000627:therapeutic use
D014750:Vincristine; D011241:Prednisone