Anti-thymocyte autoimmunity in BALB/C mice accompanying immunization to a syngeneic lymphoma.
As immunization of BALB/c mice to the syngeneic P1798 lymphoma is effected by administration of iodoacetamide-modified P1798 cells, serum antibodies appear which are reactive with P1798 and normal BALB/c thymocytes, splenocytes, and peripheral blood lymphocytes. Anti-P1798 serum also cross-reacted with thymocytes from AKR, DBA/2, and C3H mice as well as the allogeneic lymphoma 6C3HED. Anti-P1798 serum was unreactive with the Thy-1 deficient L1210 lymphoma. Multiple absorptions of anti-P1798 serum with normal BALB/c thymocytes or brain or P1798 removed antibodies to P1798 and thymocytes commensurately. Normal BALB/c liver and kidney did not absorb antibody activity. Treatment of a BALB/c splenocyte suspension with anti-Thy 1.2 serum and complement removed the population of spleen cells which were capable of reaction with anti-P1798 serum. The data suggest that antibodies to P1798 and thymocytes are the same and that specificity may be directed toward a Thy-1 related structure but without distinguishing Thy-1.1 and Thy-1.2.
D000818:Animals; D000912:Antibodies, Neoplasm; D000917:Antibody Formation; D000918:Antibody Specificity; D000956:Antigens, Viral; D001323:Autoantibodies; D005260:Female; D007114:Immunization; D007519:Isoantigens; D007939:Leukemia L1210 / Q000276:immunology; D008223:Lymphoma / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000956:Antigens, Viral; D001323:Autoantibodies; D007519:Isoantigens