Vincristine's effect on dentinogenesis in rat incisor.
Vincristine was administered to 60 rats in four groups in doses of 0.1, 0.3, 0.5 and 0.7 mg/kg. Histomorphologic investigation of the dentin and odontoblasts in the maxillary incisors after 1, 2 and 3 weeks revealed a moderate to severe disturbance of dentin production in some parts of the incisors. In some of the affected areas the effect seemed to be reversible in that normal-appearing dentin was found pulpal to the dentinal derangements after 2 and 3 weeks. The distribution and severity of the lesions were similar to those previously observed 3 days after injection of the same doses of vincristine.
D000818:Animals; D003782:Dental Pulp / Q000033:anatomy & histology; D003804:Dentin / Q000033:anatomy & histology / Q000187:drug effects; D003810:Dentinogenesis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007180:Incisor / Q000033:anatomy & histology / Q000187:drug effects*; D009804:Odontoblasts / Q000166:cytology / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine