Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus.
Anti-native DNA antibodies have been evaluated in forty-six lupus patients' sera for antigen-binding capacity, affinity and precipitating activity. Diffuse proliferative glomerulonephritis was significantly correlated with the presence of high serum level of free anti-native DNA antibodies. Weak affinities were more often found in patients with than without glomerular changes but several patients had high-affinity anti-DNA antibodies and severe glomerulonephritis. No correlation was found between anti-DNA antibody-precipitating activity and renal lesions.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D001666:Binding Sites, Antibody; D003378:Counterimmunoelectrophoresis; D004247:DNA / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D000974:Antibodies, Antinuclear; D004247:DNA