Expression and function of I region products on immunocompetent cells. II. I region products in T-B interaction.
The anti-Lac B precursor cells from BALB/c (H-2)d mice which survive cytotoxic treatment with anti-Iak and complement will respond to Lac-KLH in culture but require more KLH helper T cells than unselected B cell populations or B cells surviving anti-Ig killing. These findings are not explainable by the classical Poisson assumption of a constant target of T-B ionteraction. We propose a T-B interaction theory with variable Ia target on the B cell surface. The theory quantitatively predicts the observed dose response relationships, and implies that Ia molecules on B cells are cell interaction structures.
D000818:Animals; D000906:Antibodies; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D001667:Binding, Competitive; D003165:Complement System Proteins; D004306:Dose-Response Relationship, Immunologic; D006433:Hemocyanins / Q000276:immunology; D066298:In Vitro Techniques; D007785:Lactose / Q000031:analogs & derivatives / Q000276:immunology; D008433:Mathematics; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D003165:Complement System Proteins; D006433:Hemocyanins; D007785:Lactose