Lipoidal bladder concretion: an unusual autopsy finding in acute lymphoblastic leukemia.
The occurrence of a large (2.3 gm.), wax-like, creamy white concretion in the bladder of a 7-year-old girl who died of acute lymphoblastic leukemia is reported. Lipids constituted 40% of the total weight and triglycerides accounted for 95% of the total lipids. The fatty acid composition of the individual lipid classes showed a predominance of saturated fatty acids (75 to 80%). Factors influencing the pathogenesis of the material are discussed. A review of the literature on childhood leukemia showed no reference to such lipid abnormalities and the occurrence of this type of concretion has not been reported previously.
D002675:Child, Preschool; D002784:Cholesterol / Q000032:analysis; D002788:Cholesterol Esters / Q000032:analysis; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D008055:Lipids / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D014280:Triglycerides / Q000032:analysis; D001744:Urinary Bladder Calculi / Q000209:etiology*
D002788:Cholesterol Esters; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol