Alteration of lidocaine-induced convulsions by meperidine and nitrous oxide.
When mice were pretreated with meperidine, the incidence of lidocaine-induced convulsions was increased. Nitrous oxide-oxygen (N2O-02) offered no protection against convulsions caused by lidocaine alone but lowered the incidence of lidocaine-induced convulsions of mice pretreated with meperidine.
D000818:Animals; D004347:Drug Interactions; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
D008012:Lidocaine; D008614:Meperidine; D009609:Nitrous Oxide