Induction of suppressor T cells in systemic lupus erythematosus by thymosin and cultured thymic epithelium.
Patients with systemic lupus erythematosus lacked suppressor T cell function. Suppressor cell activity was induced in cells from many of these patients by incubation with thymosin or cultured thymic epithelium. These results suggest that thymic manipulation may be a useful therapeutic modality in this disease.
D000293:Adolescent; D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D046508:Culture Techniques; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013947:Thymosin / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology*; D013951:Thymus Hormones / Q000494:pharmacology*
D013951:Thymus Hormones; D003208:Concanavalin A; D013947:Thymosin