A patient with pure gonadal dysgenesis, gonadal tumour and virilisation.
A phenotypic female, karyotype XY presented with virilisation and amenorrhoea. The gonads showed evidence of oestrogen and testosterone production and, in view of the risk of malignancy, a laparotomy was performed. A streak gonad was present on one side with a streak gonad containing discrete tumours on the other. The uterus and Fallopian tubes were present. Removal of the gonads and uterus and subsequent oestrogen replacement therapy have produced a satisfactory clinical result.
D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D006063:Chorionic Gonadotropin; D004407:Dysgerminoma / Q000150:complications* / Q000473:pathology; D004700:Endocrine System Diseases / Q000150:complications / Q000473:pathology; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY; D006066:Gonads / Q000473:pathology; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D014770:Virilism / Q000150:complications*
D006063:Chorionic Gonadotropin