Experimental models for studies on transportation of antibiotics to extravasal compartments.
A short review is presented illustrating different methods employed to determine the antibiotic concentration in different tissues in man and the limitation to perform thorough pharmacokinetic studies. The most often used experimental models (different tissue cage models the fibrin clot, skin blisters, skin windows, skin chambers) applied in animal and man for studies of antibiotics are presented as well as a discussion concerning their relevance to the clinical situation.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000378:metabolism*; D001826:Body Fluids / Q000032:analysis; D002511:Cephalosporins / Q000032:analysis / Q000378:metabolism; D046508:Culture Techniques; D005110:Extracellular Space / Q000032:analysis; D005337:Fibrin; D006801:Humans; D008722:Methods; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D012867:Skin / Q000032:analysis; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005337:Fibrin