The pathologic new bone formation of an osteogenic sarcoma.
The authors describe the structure of bone and tumorous new bone formation of an amputated femur affected by osteogenic sarcoma. They studied a slide of the invaded bone using stereomicroscopic and comparative histologic techniques. The bone destruction induced by the tumor produces characteristic morphologic changes both in the cortical and in the cancellous bone. Investigation of the extraosseal tumorous bone formation is described together with its relation to the cortical bone. In the development of tumorous bone plates primary and secondary formations could be distinguished. The intraosseal, tumor-induced new bone/osteoid formation appears characteristically in the invaded marrow-spaces as a so-called "miniature spongiosa". In the zone adjacent to the tumor, reactive bony spines grow out from the surface of the normal spongy plates. These findings are also analyzed from the view of the roentgenologic findings.
D000328:Adult; D000671:Amputation, Surgical; D001846:Bone Development; D005260:Female; D005269:Femur / Q000473:pathology*; D006801:Humans; D007866:Leg; D010006:Osteoblasts; D012516:Osteosarcoma / Q000473:pathology* / Q000601:surgery; D012598:Sclerosis / Q000209:etiology