The effect of glucocorticosteroid administration on the survival of patients with acute myocardial infarction.
Because of conflicting reports in the literature, we decided to test the effect of the administration of glucocorticosteroids on the survival of patients with A.M.I. admitted to hospital within 24 hours from the beginning of symptoms. When tested by sex, age or as a whole, there was no significant difference between the steroid treated group and controls. However, recent reports show that steroids reduce the size of the infarction and improve the chances for survival and less late complications in experimental animals. We feel that renewed efforts in this direction should be made, possibly with larger doses of steroids and for longer periods.
D000367:Age Factors; D000368:Aged; D003348:Cortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D012737:Sex Factors
D003348:Cortisone; D006854:Hydrocortisone