Studies on immune responses to parasite antigens in mice. V. Different susceptibilities of hypothymic and intact mice to Babesia rodhaini.
Hypothymic BALB/c.nu/nu mice are more resistant than intact BALB/c.nu/+ mice to Babesia rodhaini and a proportion survive a dose of infected blood which is uniformly lethal to nu/+ mice. This proportion of nu/nu survivors is not affected by administration of an anti-Babesial drug, whereas the majority of nu/ + mice develop a long-lasting resistance to infection. The data suggest that T cell dependent activities are involved both in the acceleration of parasitaemia and in the development of drug-assisted resistance.
D000818:Animals; D001404:Babesiosis; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D007109:Immunity; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors