Selective expression of separate I-region loci in functionally different lymphocyte subpopulations.
Determinants controlled by separate loci mapping in the I region of the H-2 gene complex are selectively expressed on subpopulations of lymphocytes which play different roles in generating humoral responses. The Ia-4 locus, which marks a new I subregion, designated I-J, controls determinants found on allotype suppressor and normal (nonsuppressed) T lymphocytes. These determinants are not present on helper T lymphocytes or B lymphocytes. In contrast, the Ia-1 locus, which marks the I-A subregion, controls determinants present on B lymphocytes but not on suppressor or helper T lymphocytes. Another locus (subregion not known) controls determinants which distinguish helper T lymphocytes from suppressor T lymphocytes. Such selective expression suggests that the products of these loci may plan an integral role in lymphocyte interactions.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D005796:Genes; D006649:Histocompatibility Antigens; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens