[Foetal antigens on leukaemia cells (author's transl)].
An antiserum against human foetal liver cells reacted in in-vitro-cytotoxic test with the leukaemia cells of 6 out of 10 children with acute lymphocytic leukaemias (ALL) and with the lymphoma cells of 1 out 2 children with lymphosarcoma (LS). No cytotoxic reactions were obtained against leukaemia cells of 5 children with acute myelogenic leukaemia (AML), leukaemia cells of 7 adults with chronic lymphocytic leukaemia (CLL), bone marrow cells of 9 children in clinical remission and lymphocytes of normal donors. The cytotoxic activity of the anti-foetalserum was removed by absorption with foetal liver but not with adult liver. The results suggest that foetal antigens may occur on ALL-cells and LS-cells.
D000328:Adult; D000941:Antigens; D000951:Antigens, Neoplasm; D002648:Child; D003602:Cytotoxicity, Immunologic; D005333:Fetus / Q000276:immunology*; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D008099:Liver / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology
D000941:Antigens; D000951:Antigens, Neoplasm
Fötale Antigene auf Leukämiezellen.