Cellular regulation of the metabolism of androgens in rat oral mucosa: I. Effect of medroxyprogesterone acetate (MPA) on the soluble supernatant (cytosol) activating microsomal delta4-3-ketosteroid-5alpha-reductase and 17beta-hydroxysteroid oxidoreductase enzyme systems.
Soluble supernatant (cytosol) of rat oral mucosa was found to contain a factor accelerating the activity of microsomal delta4-3-ketosteroid-5alpha-reductase and 17beta-hydroxysteroid oxidoreductase enzymes metabolizing testosterone. Systemic administration of medroxyprogesterone acetate further increased this cytosolic activity.
D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000728:Androgens / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000502:physiology*; D004789:Enzyme Activation / Q000187:drug effects; D008525:Medroxyprogesterone / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology*; D009061:Mouth Mucosa / Q000166:cytology / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D011372:Progestins / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013739:Testosterone / Q000378:metabolism*
D000728:Androgens; D011372:Progestins; D013739:Testosterone; D010088:Oxidoreductases; D015067:17-Hydroxysteroid Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D008525:Medroxyprogesterone