Differential effect of vinblastine and colchicine on human active and total T rosettes.
The effect of vinblastine and colchicine on human blood T cell rosette formation with sheep erythrocytes was assessed. For some concentrations, both drugs increased the percentage of active T rosettes. In contrast, the total T rosette percentage was decreased by the same drugs. These experiments further confirm the heterogeneity of T cell rosettes and suggest the existence of three types of sheep red blood cell receptors on human blood T lymphocytes.
D003078:Colchicine / Q000494:pharmacology*; D006801:Humans; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D003078:Colchicine