Effects of local anesthetics on the respiratory activity in vitro of cells in the dental pulp.
The respiratory activity of isolated dental pulps from rat incisors was studied using a Gilson respirometer. The activity was compared with activities after administration of varying concentrations of commercial standard solutions of lidocaine with and without adrenaline and prilocaine with felypressin. Above a 2.5% concentration of the standard solution added to the respiratory medium a significant inhibition was registered.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005259:Felypressin / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D011318:Prilocaine / Q000494:pharmacology; D051381:Rats
D000779:Anesthetics, Local; D011318:Prilocaine; D005259:Felypressin; D008012:Lidocaine; D004837:Epinephrine