title: Effect of estradiol and progesterone on udder growth in goats in vivo and lipid synthesis in goat mammary tissue in vitro.
abstract: The effect of estradiol-17beta (E) and progesterone (P) and E, P and deprenon (D; an inhibitor of prolactin secretion) treatment on udder growth, colostrum-like formation and on the induction of lipid synthesis in mammary organ culture were studied. Administration of E and P for 8-14 days induced udder growth and colostrum formation. Intensive mammary growth and udder distention with secretion occurred following hormone treatment. Simultaneous administration of D prevented both udder growth and colostrum formation. In mammary explants from E, P and D treated goats the rate of incorporation 14C-acetate into lipids was increased by insulin (I), cortisol (F) and prolactin (M) as compared with the effect of I or I plus F. The tissue from placebo treated goats and goats treated with E and P responded to M either slightly or not at all. The high sensitivity of mammary tissue from goats treated with E, P and D to M was demonstrated immediately following the administration of E and P for 8 days and also 10 days after the treatment, but not 23 days following hormone administration.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000818:Animals; D003126:Colostrum / Q000378:metabolism; D004873:Ergolines / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006041:Goats; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology
chemical_list: D000085:Acetates; D004873:Ergolines; D007328:Insulin; D008055:Lipids; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D006854:Hydrocortisone