Survival of synchronized V79 cells treated with X-rays and cordycepin.
The survival of V79 Chinese hamster lung cells exposed to X-irradiation is reduced by co-treatment with cordycepin (3'-deoxyadenosine). This reduction is manifested principally by a decrease in the D0 of the X-ray survival curve from 199 rad in untreated cells to 106 rad in cordycepin-treated cells. Reduced survival is seen throughout the life-cycle when synchronized cell populations are exposed to both agents with cells in mid-S being especially sensitive.
D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D003839:Deoxyadenosines / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors
D003839:Deoxyadenosines