Effect of chlorhexidine gluconate on acute nonmicrobial inflammation reaction.
The effects of chlorhexidine on the appearance of leukocytes and some hydrolytic enzymes were studied in an experimental acute nonmicrobial inflammation reaction caused by implanation of viscose sponge beneath the backskin. The results showed that chlorhexidine gluconate decreased the number of leukocytes in the inflammatory exudate. The drug used had no measurable effect on the distribution of different types of leukocytes. Chlorhexidine has a clear inhibitory effect on the appearance of phosphatases, glycosidases and peptidases. On the other hand the effect on proteinases was small.
D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D002710:Chlorhexidine / Q000032:analysis / Q000494:pharmacology*; D005122:Exudates and Transudates / Q000187:drug effects; D005260:Female; D005942:Gluconates / Q000032:analysis / Q000494:pharmacology; D007249:Inflammation; D007962:Leukocytes / Q000032:analysis / Q000187:drug effects; D008297:Male; D051381:Rats
D001645:Biguanides; D005942:Gluconates; D002710:Chlorhexidine