title: A lod score method for detecting linkage on the X chromosone between a marker locus and a major gene locus for a quantitative.
abstract: A sequential lod-score method is proposed for detecting linkage on the X chromosome between a marker locus and the locus of a major gene influencing a quantitative trait, The method uses information from sons of doubly heterozygous mothers. The average number of families required to detect linkage is substantially less than that of the fixed sample-size method proposed by Hill.
mesh_terms: D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008297:Male; D008433:Mathematics; D008957:Models, Genetic; D012730:Sex Chromosomes; D014960:X Chromosome
chemical_list: D005819:Genetic Markers