[Protective effect of sodium hydroxybutyrate and mexamine on the body and cerebral cortex neurons during hypoxia].
Experiments on white non-pure male mice have established that NA oxybutirate in doses 100 mg/kg and mexamine in doses 2.5 mg/kg possess antihypoxic properties in conditions of severe hypoxia corresponding to a height of 10 000 m. In a combined introduction of Na oxybutirate and mexamine in the above-mentioned doses there is an increase of their antihypoxic action. It was demonstrated that Na oxybutirate, mexamine and their combination exposes a distinct protective effect on the cortical neurons on rats in conditions of hypoxia. It is assumed that the protective action of the studied antihypoxants on the cortical neurons is realized with the aid of the same mechanisms as in a physiological adaptation to hypoxia.
D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D004357:Drug Synergism; D006168:Guinea Pigs; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051381:Rats; D012978:Sodium Oxybate / Q000008:administration & dosage / Q000627:therapeutic use*; D014363:Tryptamines / Q000627:therapeutic use*
D006885:Hydroxybutyrates; D014363:Tryptamines; D008735:5-Methoxytryptamine; D012978:Sodium Oxybate
Zashchitnoe deĭstvie oksibutirata natriia, meksamina na organizm i neĭrony kory golovnogo mozga v usloviiakh gipoksii.