[Aqueous humor levels of gentamicin after parenteral, subconjunctival and topical administration (aithor's transl)].
The purpose of this study was to determine the concentration of Gentamicin in blood serum and primary aqueous humor at varying periods of time after intravenous, intramuscular, subconjunctival and topical administration of Gentamicin. Therapeutic effective levels in primary aqueous humor were measured only after subconjunctival injections. The only broad spectrum antibiotics are the aminoglykosides Gentamicin, Tobramycin, Sisomicin and Amikacin. For prompt treatment of bacterial endophthalmitis without bacterial culture and antibiotic sensitivity testing therefore subconjunctival injection of Gentamicin is necessary.
D000287:Administration, Topical; D001082:Aqueous Humor / Q000378:metabolism*; D003228:Conjunctiva; D009877:Endophthalmitis / Q000188:drug therapy; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous
D005839:Gentamicins
Gentamicinspiegel im Kammerwasser des Menschen nach parenteraler, subkonjunktivaler und lokaler Applikation.