Development of acute myeloid leukaemia in a patient with psoriasis treated with oral 8-methoxypsoralen and longwave ultraviolet light.
Acute myeloid leukaemia developed in a patient with psoriasis treated with oral 8-methoxypsoralen and longwave ultraviolet light (PUVA) 2 years earlier. Attention is called to the possibility that the effect of PUVA on DNA synthesis may not be limited to the areas of the skin being treated but - through damage to circulating multipotential stem cells - may also lead to haematological malignancies.
D000368:Aged; D002273:Carcinogens; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008730:Methoxsalen / Q000009:adverse effects* / Q000627:therapeutic use; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy*
D002273:Carcinogens; D008730:Methoxsalen