Nalidixic acid and lactic acidosis.
Nalidixic acid may cause severe acidosis and we report a fatal case of lactic acidosis assocaited with nalidixic acid therapy. Studies in normal volunteers showed drug related impairment of lactate metabolism. We question whether the drug should be used in patients who may accumulate the drug or be predisposed to lactic acidosis.
D000138:Acidosis / Q000097:blood / Q000139:chemically induced*; D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009268:Nalidixic Acid / Q000009:adverse effects* / Q000494:pharmacology
D007773:Lactates; D009268:Nalidixic Acid