[Human, guinea pig and rat lympocyte rosette formation with spermatozoids].
In the thymus, spleen and bone marrow of adult guinea pigs, 14--30-week human fetuses, and the peripheral blood of sterile men there were found cells capable of forming the rosettes with homo- or heterologous spermatozoa (RFC). Development of autoimmune orchitis after the trauma of the rat testis or after the guinea pig immunization with the testicular homogenate mixed with complete Freund's adjuvant caused the appearance of RFC with spermatozoa in the thymus and the spleen of rats, and an increase of their number in the lymphoid organs of guinea pigs. Such treatment did not influence the quantity of sheep-cell rosettes in the lymphoid organs of rats and guinea pigs. A possibility of using the detected capacity of animal and human lymphocytes to form spontaneous and immune rosettes with the spermatozoa to test the degree of lympocyte differentiation and their sensitisation to the spermatozoa antigens after the spermatogenesis distrubances of the autoimmune nature is discussed.
D000818:Animals; D001323:Autoantibodies; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D007104:Immune Adherence Reaction; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051381:Rats; D013094:Spermatozoa / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013737:Testis / Q000293:injuries
D001323:Autoantibodies; D005620:Freund's Adjuvant
Obrazovaine limfotsitami cheloveka, morskikh svinok i krys rozetok so spermatozoidami