Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus.
Swiss mice infected at birth with lymphocytic choriomeningitis virus develop glomerulonephritis. Injection of potent anti-mouse interferon globulin at the time of viral infection inhibited the development of these renal lesions. We conclude that the production of endogenous interferon by this virus in the first few days of life plays an important role in the pathogenesis of this glomerulonephritis.
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000008:administration & dosage; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral / Q000032:analysis; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007372:Interferons / Q000276:immunology*; D008216:Lymphocytic Choriomeningitis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D008217:Lymphocytic choriomeningitis virus; D051379:Mice
D000906:Antibodies; D000956:Antigens, Viral; D007372:Interferons