Sensitization of mouse tumours using fractionated X-irradiation.
The response of 3 different tumours to single doses and fractionated irradiation with and without misonidazole was compared. The osteosarcoma BS2 showed no significant drop in sensitization for 2 fractions compared with a single dose. The rapidly shrinking carcinoma NT and the non-shrinking fibrosarcoma showed a significant drop in the SER as the radiation dose was fractionated. This is consistent with effective reoxygenation occurring in both tumours. No sensitizing effect was observed in the fibrosarcoma for 5 fractions each given with metronidazole. When only 2 out of 5 fractions were given with the drug misonidazole, they were slightly more effective with the first 2 than with the last 2 fractions.
D000818:Animals; D051379:Mice; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D009593:Nitroimidazoles / Q000494:pharmacology*; D010100:Oxygen; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D010100:Oxygen