Changes in cardiac output during the development of renal hypertension in sodium-depleted dogs.
1. Chronic renovascular hypertension developed in uninephrectomized, sodium-depleted dogs in association with a decrease in cardiac output. 2. With sodium and volume repletion of these animals, cardiac output returned to normal but the high level of arterial pressure was unchanged; consequently, the peripheral arterioles dilated. 3. These observations provide evidence against the theory of whole-body autoregulation.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D002302:Cardiac Output; D004285:Dogs; D006977:Hypertension, Renal / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D009318:Natriuresis; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance
D012964:Sodium; D012083:Renin