Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.
The Rfv-3 gene was found to influence the level of Friend leukemia virus production in spleens of leukemic mice later than 30 days after virus inoculation. Rfv-3r/s mice [(B10.A X A)F1 and (B10.A X A.BY)F1] had decreased spleen virus levels 30-90 days after virus inoculation compared to Rfv-3s/s mice [A.BY, A, BALB.B, and (BALB/c X A)F1)]. In (B10.A X A)F1 X A backcross mice the spleen virus titer segregated with the level of viremia. The Rfv-3 gene appeared to act by controlling anti-Friend virus antibody production. The interaction of antiviral antibody with infected cells led to a decrease in release of infectious virus by late leukemic spleen cells in Rfv-3r/s mice to 1/300th that in Rfv-3s/s mice. This decrease in virus release appeared to be due to interference with the virus budding process due to antibody-mediated modulation of virus-induced cell surface antigens.
D000818:Animals; D000914:Antibodies, Viral; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface; D000956:Antigens, Viral; D001769:Blood / Q000382:microbiology; D005622:Friend murine leukemia virus / Q000276:immunology; D005814:Genes, Viral; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology* / Q000382:microbiology; D007942:Leukemia, Experimental / Q000276:immunology; D013154:Spleen / Q000382:microbiology; D014779:Virus Replication
D000914:Antibodies, Viral; D000954:Antigens, Surface; D000956:Antigens, Viral