Antigenic spectrum of soluble serum glycoproteins in rheumatoid arthritis.
Compared with healthy controls, rheumatoid arthritis patients were found to have higher serum (1 M) perchlorate filtrate (CHLF) levels of alpha-antitrypsin. In addition to orosomucoid, alpha2-HS-glycoprotein, haptoglobin, haemopexin and beta2-glycoprotein, the filtrate also contains detectable amounts of albumin, prealbumin and - in patients with high serum glycoprotein levels - also IgA. Serum sulphosalicylate filtrate (SF) contains chiefly orosomucoid, together with alpha1-antitrypsin, haptoglobin, haemopexin and beta2-glycoprotein. CHLF contains larger amounts of glycoprotein than SF. The glycoproteins of CHLF correlate with the patient's synovitis, while a high SF glycoprotein content, as estimated by the polarographic activity of the sulphydryl groups, tends to be indicative of visceral complications of RA.
D000941:Antigens / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000032:analysis; D009961:Orosomucoid / Q000276:immunology; D012995:Solubility; D000515:alpha 1-Antitrypsin / Q000276:immunology
D000941:Antigens; D006023:Glycoproteins; D006242:Haptoglobins; D007136:Immunoglobulins; D009961:Orosomucoid; D000515:alpha 1-Antitrypsin