[Relative gnotobiosis: a possibility for studying periodontal diseases in the rat].
An animal model was presented to study periodontal disease in Osborne-Mendel rats with depressed indigenous oral flora. In connection with the inoculation of an erythromycin-resistant strain A. viscosus Ny 1 E after 40 experimental days only the animals showed plaque formation, bleeding from the gingival sulcus upon gentle probing and severe alveolar bone loss. 56% sucrose in the diet counteracted the establishment of A. viscosus Ny 1 E in dental plaques. As a consequence plaque formation, gingival bleeding and bone loss diminished. Plaque formation, gingival bleeding and bone loss were correlated.
D000190:Actinomyces; D000196:Actinomycosis / Q000150:complications*; D000539:Alveolar Process; D000818:Animals; D001862:Bone Resorption / Q000209:etiology; D003773:Dental Plaque / Q000209:etiology / Q000382:microbiology; D004040:Dietary Carbohydrates; D004195:Disease Models, Animal; D005856:Germ-Free Life; D005884:Gingival Hemorrhage / Q000209:etiology; D010510:Periodontal Diseases / Q000209:etiology*; D051381:Rats; D013395:Sucrose / Q000494:pharmacology
D004040:Dietary Carbohydrates; D013395:Sucrose
Relative Gnotobiose: eine Möglichkeit zum Studium parodontaler Erkrankungen an der Ratte.