Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control.
Mercuric chloride induces anti-glomerular basement membrane antibodies in the Brown-Norway rat. Various other inbred rat strains (Lewis, Wistar AG, August, PVG/c) were not found to be able to produce such antibodies under the same experimental conditions. Hybrids (F1, F2 and F1 x LEW) were bred from Brown-Norway and Lewis rats and injected with mercuric chloride. It has been demonstrated that the induction of anti-glomerular basement membrane antibodies by mercuric chloride in these crosses is under genetic control. The response was found to depend on two or three genes one of which was H-1-linked. The negative results obtained with L.BN congenic rats were in complete agreement with this conclusion.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001485:Basement Membrane / Q000276:immunology*; D005260:Female; D005796:Genes; D005838:Genotype; D006648:Histocompatibility; D006824:Hybridization, Genetic; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D008628:Mercury / Q000494:pharmacology*; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013045:Species Specificity
D008628:Mercury