title: [Pharmacokinetic aspects of overdosage and intoxication with oral anticoagulant drugs (author's transl)].
abstract: Three aspects of treatment with oral anticoagulant drugs are discussed: 1. Drug interactions which can lead to changes in the elimination or distribution of oral anticoagulant drugs with special emphasis on the time course of the augmentation of the anticoagulant effect. 2. Pharmacokinetic factors responsible for inter- and intrasubject differences in the response to oral anticoagulant drugs. 3. Treatment of overdosage and intoxication with oral anticoagulant drugs. Besides symptomatic treatment with vitamin K and prothrombin complex concentrate the interruption of the enterohepatic recycling by cholestyramine is demonstrated as a useful method for enhancing the elimination of phenprocoumon and warfarin from the body.
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D002792:Cholestyramine Resin
vernacular_title: Pharmakokinetische Aspekte der Uberdosierung und Intoxikation mit oralen Antikoagulantien.