Physiological and chemical characterization of invertebrate metallothionein-like proteins.
Metallothionein-like proteins have been isolated from marine invertebrates. Three crustaceans, Scyllus serratus, Cancer magister and Acetes sibogae together with a mollusc, Cryptochiton stelleri, have been investigated. S. serratus hepatopancreas was shown to contain cadmium and zinc inducible metallothionein-like proteins with an amino acid analysis very similar to vertebrate metallothioneins. The molecular weight, ultra-violet spectrum and isoelectric points of S. serratus metallothioneins are also comparable to the vertebrate proteins, suggesting a fundamental biological function conserved throughout evolution.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D003445:Crustacea / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008667:Metalloproteins / Q000096:biosynthesis* / Q000302:isolation & purification; D008668:Metallothionein; D008974:Mollusca / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D013045:Species Specificity
D000596:Amino Acids; D008667:Metalloproteins; D002104:Cadmium; D008668:Metallothionein