title: Differentiating limb tissue affects neurite growth in spinal cord cultures.
abstract: Limb bud mesenchyme enhances and directs the growth of tadpole spinal cord nerve fibers in tissue culture. This effect on elongating neurites may involve alterations in nerve-substratum interactions by the presence of undifferentiated target tissues. The relationship between nerve fibers and their potential innervation sites can explain directed nerve growth to the developing limb.
mesh_terms: D000367:Age Factors; D000818:Animals; D001001:Anura; D002454:Cell Differentiation; D046508:Culture Techniques; D004627:Embryonic Induction; D005121:Extremities / Q000196:embryology* / Q000294:innervation; D006321:Heart / Q000196:embryology; D008099:Liver / Q000196:embryology; D008648:Mesoderm / Q000502:physiology; D011894:Rana pipiens; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*