title: Experience with a slow-release formulation of oxprenolol.
abstract: Fifteen hypertensive patients with well controlled blood pressure on antihypertensive regiments consisting of a diuretic (in all but one) and a thrice-daily regimen of oxprenolol, were switched to an equal total daily dose of slow-release oxprenolol given once daily. Other drugs were continued unchanged. Observations on blood pressure and heart rate during half-day tests (lying, standing and post-exercise) indicated a little loss of control of the blood pressure towards the end of the 24-hour period when the next daily dose was due. Ectopic beats associated with exertion were observed more frequently at the end of the 24-hour period. Maximum advantage would seem to be gained by giving slow-release oxprenolol as a twice daily regimen with two-thirds of the daily dose in the morning and one-third at night.
mesh_terms: D001794:Blood Pressure; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D010096:Oxprenolol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011674:Pulse
chemical_list: D003692:Delayed-Action Preparations; D010096:Oxprenolol