Trisomy 8 in the chronic phase of Philadelphia negative chronic myelocytic leukaemia.
An unusual case of Philadelphia negative chronic myelocytic leukaemia and an extra chromosome 8 in all bone marrow cells is described. The abnormality was present at diagnosis of the disease and throughout the chronic phase which lasted for somewhat less than 2 years. The patient died soon after the blastic transformation with no other chromosomal abnormalities.
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics*; D008677:Metaphase; D011379:Prognosis; D013997:Time Factors; D014314:Trisomy