[Effect of cortisone on calcium metabolism. Attempt at correction by 5,6 trans 25-hydroxycholecalciferol, 25-hydroxycholecalciferol and vitamin D2].
14 patients receiving small doses of predisolone and 7 high doses were divided at random into three groups. Each group received for four weeks, 100 microgram of vitamin D2 or 25 hydroxyvitamin D3 or 5,6 trans-25 hydroxyvitamin D3. The 25 hydroxy and 5,6 trans-25 hydroxyvitamine D3 were able to increase intestinal calcium absorption. 25 Hydroxyvitamin D3 had an osteolytic action, increasing urine calcium and hydroxyproline and, once, in a patient slight hypercalcemia was observed. By constrast, 5,6 trans-25 hydroxyvitamin D3 decreased PTH and caused a significant decrease in urine hydroxyproline.
D002118:Calcium / Q000378:metabolism*; D003348:Cortisone / Q000494:pharmacology*; D004872:Ergocalciferols / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011239:Prednisolone / Q000494:pharmacology
D004872:Ergocalciferols; D006887:Hydroxycholecalciferols; D011239:Prednisolone; D002118:Calcium; D003348:Cortisone
Effet des cortisoniques sur le métabolisme calcique. Essai de correction par le 5,6 trans 25-hydroxycholécalciférol, le 25-hydroxycholécalciférol et la vitamine D2.