[Determination of serum and saliva concentrations of clindamycin (Dalacin C) and amoxicillin (Clamoxyl)].
The antibiotic therapy of oral infections requires bactericidal concentrations in the oral environment over sufficient time. Comparable determination of antibiotica concentration in the saliva of 8 human volunteers were made after oral application of Amoxycillin and Clindamycin. Only Clindamycin showed inhibitory concentrations.--When pharmacokinetic characteristics and the present status of resistance were considered, Clindamycin is viewed as an antibiotic of choice for oral infections.
D000658:Amoxicillin / Q000032:analysis* / Q000097:blood / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002981:Clindamycin / Q000032:analysis* / Q000097:blood / Q000494:pharmacology; D006801:Humans; D009059:Mouth Diseases / Q000188:drug therapy; D010403:Penicillin Resistance; D012463:Saliva / Q000032:analysis*
D002981:Clindamycin; D000658:Amoxicillin
Bestimmung der Serum- and Speichelkonzentrationen von Clindamycin (Dalacin C) und Amoxycillin (Clamoxyl).