Contamination of germfree animals with intestinal Crohn tissue. A preliminary report.
The preliminary results of one of a series of prospective studies in the investigation of a possible transmissible agent in Crohn's disease are presented. Filtered human Crohn tissue homogenates was inoculated into eight germfree Sprague-Dawley rats, to test the reproducibility of recent reports suggesting a transmissible agent in regional ileitis. No histological changes were evident after 150 days, and no changes were observed in animals inoculated with non-Crohn tissue homogenates.
D000818:Animals; D003424:Crohn Disease / Q000382:microbiology* / Q000635:transmission; D005856:Germ-Free Life; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D051381:Rats