O2 consumption of the amphibian cornea: relationship to Na+ and Cl- and the presence of drugs.
Thirty percent of the O2 consumption of the amphibian cornea was Na-dependent. Ouabain, in the presence but not the absence of this cation, inhibits O2 uptake by about 30 patient. In contrast, neither the presence of Cl- nor drugs which stimulate (adrenaline, theophylline) or inhibit (furosemide, thiocyanate) active transport of this anion had detectable effects on O2 consumption.
D000818:Animals; D001001:Anura; D001693:Biological Transport, Active / Q000187:drug effects; D002713:Chlorine / Q000494:pharmacology*; D003315:Cornea / Q000378:metabolism*; D003864:Depression, Chemical; D004837:Epinephrine / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D010101:Oxygen Consumption; D011892:Rana catesbeiana / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology; D013861:Thiocyanates / Q000494:pharmacology
D013861:Thiocyanates; D002713:Chlorine; D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D013806:Theophylline; D004837:Epinephrine