Diffuse microglial proliferation after global ischemia in a patient with aplastic bone marrow.
Abundant proliferation of cells having the histologic and tinctorial features of microglia, were seen in the brain of 34-year old man who suffered cardiac arrest 10 days before death and whose bone marrow was nearly totally depleted of white-blood-cell precursors. It is suggested, that in adult human brains there are native microglial precursors which can take on a phagocytic function. Therefore, brain macrophages do not have to originate from circulating monocytes, as suggested by some animal studies.
D000328:Adult; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology*; D006323:Heart Arrest / Q000150:complications; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008264:Macrophages; D008297:Male; D009457:Neuroglia / Q000473:pathology*; D010587:Phagocytosis; D013997:Time Factors