title: 37 degrees CE rosettes in various malignant and non-malignant disorders.
abstract: T lymphocytes, forming sheep erythrocyte rosettes at 37 degrees C, have been described in thymus glands, mitogen and allogeneic cell stimulated lymphocyte cultures, and acute T cell lymphoblastic leukaemia. This paper describes the finding of such lymphocytes in lymph nodes of a variety of disorders including Hodgkin's disease, Lennert's lymphoma, malignant lymphoma of large transformed T lymphocytes, immunoblastic lymphadenopathy, metastatic carcinoma, and other disorders. A large number of tonsils, but not reactive lymph nodes, also contained a significant number of those T lymphocytes. The significance of these findings in relation to interpretation of immune red cell rosettes and to the subclasses of T lymphocytes is discussed.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D012397:Rosette Formation; D012751:Sezary Syndrome / Q000276:immunology; D012756:Sheep; D013696:Temperature; D013997:Time Factors