A hyperimmunoglobulin E syndrome with normal chemotaxis in vitro and defective leukotaxis in vivo.
A 26-yr-old male with a lifelong history of atopic dermatitis and recurrent severe staphylococcal abscesses was found to have hyperimmunoglobulinemia E. Evaluation of both the humoral and cellular aspects of chemotaxis in vitro showed both neutrophils and monocytes to be normal. However, quantitative neutrophil migration in vivo was significantly suppressed using the patient's own serum as the attractant. This defective migration in vivo was partially corrected by serum from normal donors as the attractant and also partially corrected following plasma infusion in this patient. Evaluation of quantitative leukocyte migration in vivo may be most useful in patients suspected of defects of leukocyte mobility.
D000038:Abscess; D000328:Adult; D002634:Chemotaxis, Leukocyte; D003876:Dermatitis, Atopic / Q000209:etiology; D004137:Dinitrochlorobenzene / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000503:physiopathology*; D007111:Immunity, Cellular; D007073:Immunoglobulin E; D007962:Leukocytes / Q000503:physiopathology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D008233:Lymphotoxin-alpha / Q000096:biosynthesis; D008297:Male; D010587:Phagocytosis; D012874:Skin Diseases, Infectious / Q000209:etiology; D013203:Staphylococcal Infections; D013577:Syndrome
D004137:Dinitrochlorobenzene; D008233:Lymphotoxin-alpha; D007073:Immunoglobulin E