title: Disturbances and defects in enamel development.
abstract: Ameloblastic disturbances are correlated with defects in enamel. Experimental disturbances created by tetracyclines, fluorides, and antimitotic drugs are emphasized. Cellular alterations are shown to interfere with both matrix production and secretion. Defects in enamel formation are characterized by abnormal crystal size and distribution. Further research in normal and particularly abnormal enamel development is needed to establish: 1. exact mode of matrix secretion and its relation to crystal nucleation and orientation 2. function of maturative ameloblast and its relation to the stratum intermedium and papillary layer during that phase 3. cause for lack of mineralization of matrix, particularly in ectopic areas.
mesh_terms: D000135:Acid Phosphatase / Q000037:antagonists & inhibitors; D000565:Ameloblasts / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D000566:Amelogenesis / Q000187:drug effects; D000818:Animals; D002130:Calcium Phosphates / Q000378:metabolism; D003461:Crystallography; D003743:Dental Enamel / Q000033:anatomy & histology* / Q000187:drug effects; D003746:Dental Enamel Proteins / Q000378:metabolism; D005459:Fluorides / Q000494:pharmacology; D009940:Organoids / Q000648:ultrastructure; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology; D014076:Tooth Diseases / Q000473:pathology
chemical_list: D002130:Calcium Phosphates; D003746:Dental Enamel Proteins; D000135:Acid Phosphatase; D013752:Tetracycline; D005459:Fluorides