Phagocytic potential of leukaemic B-lymphocytes.
Phagocytosis of small latex particles was demonstrated by light and electron microscopy in a proportion of cells from B-lymphoproliferative disorders including chronic lymphocytic, prolymphocytic and hairy cell leukaemia. It was not observed in a case of T-chronic lymphocytic leukaemia or in normal lymphocytes. A significant correlation was observed between the binding of latex to the lymphocyte surface and the degree of phagocytosis. It is suggested that the phagocytic activity of leukaemic B-lymphocytes is mediated through their Fc receptor and that this property may also be present in normal B-cells. Among mononuclear cells, therefore, phagocytosis can no longer be considered exclusively a property of monocytes.
D001402:B-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*; D001665:Binding Sites; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007840:Latex; D007938:Leukemia / Q000097:blood* / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000097:blood / Q000276:immunology; D008863:Microspheres; D010587:Phagocytosis
D007141:Immunoglobulin Fc Fragments; D007840:Latex