[Autoradiographic study of DNA metabolism in different populations of lymphocytes during chemical carcinogenesis is mice of the BALB/c strain].
A correlation between macro- and micronuclear lymphocytes and their DNA metabolism was studied in the lymph nodes of BALB/c mice during the growth of methylcholanthrene sarcoma. The number of macronuclear lymphocytes was seen reduced along with a simultaneous increase of 3H-thymidine indices in regional lymph nodes during the tumor growth. The number of micronuclear lymphocytes of these lymph nodes was accordingly increasing. In distant lymph nodes the reaction was significantly less expressed.
D000818:Animals; D001345:Autoradiography; D001402:B-Lymphocytes / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D008748:Methylcholanthrene; D004247:DNA; D013936:Thymidine
Avtoradiograficheskoe izuchenie obmena DNK v razlichnykh populiatsiiakh limfotsitov v protsesse khimicheskogo kantserogeneza u mysheĭ linii BALB/c.