title: Hematopoietic thymocyte precursors: II. Properties of the precursors.
abstract: The properties of hematopoietic cells which serve as the precursors of cortical thymocytes in irradiated reconstituted mice have been described. These cells have been termed "prothymocytes." They are 10- to 15-mum diameter cells of low buoyant density. They are nonadherent to glass wool and more resistant to the lytic effects of steroids and gamma-irradiation than their progeny. They lack detectable amounts of the surface markers associated with either B or T cells but do bear at least two antigens recognized by antisera to mouse brain.
mesh_terms: D000818:Animals; D001665:Binding Sites; D001854:Bone Marrow Cells; D001921:Brain / Q000276:immunology; D002448:Cell Adhesion; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D002499:Centrifugation, Density Gradient; D003176:Complement C3; D005260:Female; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D006854:Hydrocortisone / Q000494:pharmacology; D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens / Q000032:analysis; D051379:Mice; D008806:Mice, Inbred AKR; D008938:Mitosis; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects
chemical_list: D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens; D011947:Receptors, Antigen, B-Cell; D006854:Hydrocortisone