A non-T, non-B human leukemia cell line (NALM-1): establishment of the cell line and presence of leukemia-associated antigens.
A permanent hematopoietic cell line, designated NALM-1, was established from the peripheral blood of a patient who was in blastic crisis of Ph1-positive chronic myleocytic leukemia. By means of a panel of specific xenoantisera, the NALM-1 cells were found to express a specific antigen of acute lymphoblastic leukemia and blast leukemia-associated antigen. The cells exhibited no cell-surface receptors for sheep erythrocytes, IgG, or complement; neither cell-surface immunoglobulins nor cytoplasmic immunoglobulin were observed. Furthermore, normal T-cell or B-cell antigens, detectable by the antisera used in this study, were not found in the NALM-1 line.
D000951:Antigens, Neoplasm; D001402:B-Lymphocytes / Q000276:immunology; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D007136:Immunoglobulins