The influence of antigen presentation on the generation of T-helper cells with different functions.
Thymocytes adoptively transferred into syngeneic irradiated recipients can be primed with antigen (KLH) to generate two types of helper function termed 'specific' and 'non-specific'. Low doses of KLH given without adjuvant generate high levels of non-specific compared to 'specific' helper T cells. Large doses of KLH given in adjuvant (FCA) generate high levels of both types of helper T cell. Explantations for this observation are discussed.
D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000008:administration & dosage*; D001402:B-Lymphocytes / Q000276:immunology; D008211:Lymphocyte Cooperation; D051379:Mice; D008808:Mice, Inbred CBA; D011830:Radiation Effects; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014185:Transplantation, Isogeneic
D000941:Antigens