title: Human heterozygosity: a new estimate.
abstract: Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.
mesh_terms: D044383:Black People; D006579:Heterozygote; D006801:Humans; D007526:Isoelectric Point; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D044465:White People
chemical_list: D011506:Proteins