Anti-inflammatory, analgesic and other related actions of 4'-chloro-5-methoxy-3-biphenylylacetic acid (DKA-9).
4'-Chloro-5-methoxy-3-biphenylylacetic acid (DKA-9) is a novel phenylacetic acid derivative with marked anti-inflammatory, analgesic and antipyretic activities. DKA-9 was approximately 2 times and 25 times more effective than ibuprofen in inhibiting carrageenin-induced paw edema and adjuvant-induced arthritis, respectively, in rats. The anti-inflammatory effect of DKA-9 was observed also in adrenalectomized rats. In the Randall-Selitto test in rats, DKA-9 was about 2 times more potent than ibuprofen and equipotent to indometacin. In lowering brewer's yeast-induced fever in rats, DKA-9 was almost 1/2 times more effective than ibuprofen. Considering from therapeutic index (ED50 in ulcerogenic effect/ED50 in carrageenin-induced edema), DKA-9 was found to be much superior to indometacin or ibuprofen.
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D002417:Cattle; D002464:Cell Migration Inhibition; D003168:Complement Fixation Tests; D004064:Digestive System / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D010648:Phenylacetates / Q000494:pharmacology*; D011489:Protein Denaturation / Q000187:drug effects; D051381:Rats
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds; D010648:Phenylacetates