title: [Acute mature myelocytic leukemia as a form of the myeloproliferative syndrome].
abstract: On the basis of five observations of adult patients with the clinical feature of mature cellular leukaemia which proved to be therapy-refractory and which was characterized by a rapid course is referred to the necessity of the differentiation of such cases from the classical myeloic leukaemia. The cardinal symptoms of this type of disease, which probably is identified with the cases described in literature as atypical chronic myelosis, as paraneutrophil leukaemia or as acute myelofibrosis, and also shows common features with the juvenile chronic myelosis, are, apart from the mature cellular differential blood picture a short life expectancy (less than 1 year), an initial thrombocytopenia, a normal or increased activity of the alkaline granulocyte phosphatase, the lack of Ph1-chromosome as well as the bad therapeutic reaction to busulfan. The observation of the simultaneously existing fibroses of the bone marrow as well as of the final increase of immature blasts induced the classification of the clinical picture as a special form of the myeloproliferative syndrome.
mesh_terms: D000208:Acute Disease; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001856:Bone Marrow Examination; D005319:Fetal Hemoglobin; D006412:Hematopoietic Stem Cells; D006801:Humans; D007951:Leukemia, Myeloid / Q000145:classification*; D015122:Mercaptopurine / Q000627:therapeutic use; D009196:Myeloproliferative Disorders / Q000145:classification*; D055728:Primary Myelofibrosis / Q000145:classification
chemical_list: D005319:Fetal Hemoglobin; D015122:Mercaptopurine; D001379:Azathioprine
vernacular_title: Die reifzellige, akut verlaufende myeloische Leukämie als Erscheinungsform des myeloproliferativen Syndroms.