Induction of I region-restricted hapten-specific cytotoxic T lymphocytes.
Murine cytotoxic T lymphocytes (CTL) reactive to TNP-conjugated syngeneic target cells do lyse to a moderate but significant extent TNP-conjugated, I region compatible but H-2K or H-2D region incompatible target cells. Antibody inhibition experiments and "cold inhibition" experiments indicate that some CTL clones recognize TNP-conjugated targets in association with syngeneic I region determinants independently of H-2K or H-2D gene products. The data suggest that besides TNP-conjugated H-2K or H-2D gene products, in principle, also TNP-conjugated I region determinants do stimulate TNP-specific CTL precursor cells and act as target antigens of TNP-specific CTL.
D000818:Animals; D000918:Antibody Specificity; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D006241:Haptens; D006649:Histocompatibility Antigens; D007518:Isoantibodies; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D014301:Trinitrobenzenes
D006241:Haptens; D006649:Histocompatibility Antigens; D007518:Isoantibodies; D014301:Trinitrobenzenes