Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.
Treatment of rabbits with D-penicillamine at doses up to 30 mg/kg, beginning either before or after the onset of antigen-induced experimental arthritis, diminished the severity of the inflammatory synovitis in a considerable proportion of animals as judged by both external joint measurements and terminal histopathological assessment. D-penicillamine treatment had no effect on serum haptoglobin concentration, haemoglobin concentration, or platelet count. The venous blood white cell count was raised when D-penicillamine treatment was started before immunisation but not when treatment began after the onset of arthritis. A transient loss of appetite was observed in animals starting D-penicillamine treatment.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001772:Blood Cell Count; D002908:Chronic Disease; D001068:Feeding and Eating Disorders / Q000139:chemically induced; D006801:Humans; D007596:Joints / Q000473:pathology; D010396:Penicillamine / Q000627:therapeutic use* / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors
D010396:Penicillamine