Hereditary perforating ulcers of the foot: "hereditary sensory radicular neuropathy".
In 4 cases of hereditary sensory radicular neuropathy the loss of pain and thermal sensibility resulting in perforating ulcers starts distally in lower extremities and progresses proximally. It has a sporadic and familial form as well as the hereditary type. In siblings inheritance appeared to be autosomal dominant. By early recognition of the disease and removing pressure from the involved areas, or spreading pressure equally over the foot with proper footwear ulcers are preventable.
D000293:Adolescent; D000328:Adult; D005260:Female; D005534:Foot Diseases / Q000235:genetics* / Q000473:pathology; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000235:genetics* / Q000473:pathology; D006801:Humans; D014456:Ulcer / Q000235:genetics* / Q000473:pathology