Biologic activities of various thymus preparations.
Thymosin and THF were prepared from total normal calf thymus (TT), from calf thymus depleted of thymocytes by whole-body irradiation (TE), and from calf thymus lymphocytes (TL). The activities of these products were compared in four different in vitro assays that monitored for various T-cell functions. The results suggest that the preparations obtained from thymus epithelium are more active in inducing T helper cell function in nude/nude mouse spleen cells than substances isolated from thymus lymphocytes. The latter seem to act on a more advanced step in the T cell line differentiation.
D000818:Animals; D002417:Cattle; D008213:Lymphocyte Activation; D051379:Mice; D008819:Mice, Nude; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013947:Thymosin / Q000032:analysis; D013949:Thymus Extracts / Q000032:analysis*
D008934:Mitogens; D013949:Thymus Extracts; D013947:Thymosin