The role of serotonergic and cholinergic systems in the aggression-stereotypy complex produced by amphetamine in mice.
The aggression--stereotypy complex (ASC) was produced in mice by administration of 15 mg/kg of amphetamine. The elevation of cerebral serotonin level in the mouse brain by administration of L-tryptophan or DL-5-hydroxytryptophan suppressed the aggressiveness without affecting significantly the stereotypy. Serotonin antagonists: methysergide and cyproheptadine, did not potentiate clearly the aggressive component of ASC. Cholinomimetics, pilocarpine and physostigmine, strongly suppressed the aggressive component, while a cholinolytic, scopolamine, evidently potentiated the elements of aggressive behavior. The aggressiveness observed in the ASC in the mouse receiving a large dose of amphetanine is predominantly dependent on the increase of activity of dopaminergic system, but seems to be functionally dependent also on the serotonergic and cholinergic systems.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001519:Behavior / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010830:Physostigmine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology
D010862:Pilocarpine; D003533:Cyproheptadine; D012701:Serotonin; D014364:Tryptophan; D010830:Physostigmine; D006916:5-Hydroxytryptophan; D012601:Scopolamine; D003913:Dextroamphetamine; D008784:Methysergide