Is early revascularization following acute coronary occlusion a safe and effective surgical procedure?
Coronary bypass surgery performed after more than 3 or 4 hours of coronary occlusion may results in serious derangements of cardiac metabolic, contractile, and electrical functions, and lead to extensive myocardial infarction, as well as to an unacceptable mortality. If the operation can be performed within the first 1 to 2 hours of acute coronary occlusion, hospital mortality rate is acceptably low. Although the average infarct size was usually reduced by reperfusion after 3 hours of experimental occlusion, in about 30 percent of cases there appeared to be no salvage of jeopardized myocardium.
D000208:Acute Disease; D000818:Animals; D001026:Coronary Artery Bypass / Q000401:mortality; D003326:Coronary Circulation; D003327:Coronary Disease / Q000601:surgery; D004285:Dogs; D006439:Hemodynamics; D006801:Humans; D009203:Myocardial Infarction / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis; D012306:Risk; D012770:Shock, Cardiogenic / Q000401:mortality; D014022:Tissue Survival