title: Model for evolution of Y chromosomes and dosage compensation.
abstract: Some difficulties with the classical model for the evolution of a genetically invert Y chromosome are discussed. An alternative model is proposed, which is based on the principle of Mullers ratchet; this involves the accumulation of chromosomes bearing deleterious mutant genes in a finite population in the absence of crossing-over. This process would result in the gradual increase, with time, in the number of mutant loci carried in an average Y chromosome, although the frequency of individual deleterious alleles at most loci remains low. It is shown that this creates a selection pressure for differentially increasing the activity of the X chromosome in heterogametic individuals at the expense of that of the Y, leading eventually to a genetically inert Y chromosome and to the evolution of dosage compensation.
mesh_terms: D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D008297:Male; D008954:Models, Biological; D009154:Mutation; D012730:Sex Chromosomes / Q000502:physiology*; D014998:Y Chromosome / Q000502:physiology*