Spontaneous regression of Friend murine leukemia virus-induced erythroleukemia. IV. Effects of radiation and athymia on leukemia regression in mice.
The spontaneous regression of the erythroleukemia induced by the regressing Friend murine leukemia virus (F-MuLV) complex was inhibited by irradiation of the animals prior to F-MuLV inoculation. This inhibition was proportional to the dose of radiation used. Treatment of the mice with the bone-seeking isotope 89Sr also inhibited erythroleukemia regression, which implicates the same effector mechanisms involved in the resistance to F-MuLV or F-MuLV-induced immunosuprression. Erythroleukemias induced in athymic nude mice by the regressing F-MuLV complex exhibited higher rates of lethality than did the leukemias in heterozygous or homozygous thymus gland-containing controls. These data suggested the involvement of the immune system in erythroleukemia regression and the specific participation of thymus cells and an 89Sr-susceptible function, perhaps marrow-dependent cells, in the process of regression.
D000818:Animals; D005622:Friend murine leukemia virus; D007109:Immunity / Q000528:radiation effects; D007165:Immunosuppression Therapy; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009365:Neoplasm Regression, Spontaneous; D013326:Strontium Radioisotopes; D014412:Tumor Virus Infections / Q000276:immunology*
D013326:Strontium Radioisotopes