[Changes in pacemaker cell activity during parasympathetic acceleration of the heart rate].
Acceleration of the heart rate can be elicited by stimulation of the extracardiac paraysmpathetic pathways (previous investigations). In this study, changes of the pacemaker APs were continually recorded with microelectrode in the sinus node cell. The data showed acceleration of the slope of slow diastolic depolarization (distolic prepotential) of the pace-maker AP during the parasympathetic positive chronotrct. The parasympathetic acceleration of the slow diastolic depolarization and of the heart rate was shown to be cholinergic by its nature.
D000200:Action Potentials; D000818:Animals; D001001:Anura; D001285:Atropine / Q000494:pharmacology; D006329:Heart Conduction System / Q000166:cytology / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D011896:Rana temporaria / Q000502:physiology; D012110:Reserpine / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology*; D014294:Trimethaphan / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology*
D014294:Trimethaphan; D001285:Atropine; D012110:Reserpine
Izmeneniia aktivnosti peĭsmekernykh kletok pri parasimpaticheskom uskorenii serdtsebieniĭ.