Symposium on pancreatitis: 1. Conservative management of acute pancreatitis.
Acute pancreatitis may present as the mild edematous type or the more rare and dangerous hemorrhagic form. The effects of the latter are believed to be due to the activation of pancreatic enzymes, notably trypsin. Therefore attempts are being directed towards suppression of pancreatic enzyme activation in the management of the condition. Aprotinin and glucagon are the agents for this purpose that have received most attention. Patients with acute hemorrhagic pancreatitis are subject to respiratory failure, which is not detectable early by clinical evidence, so that early monitoring of pulmonary function by the determination of arterial blood-gas pressures is desirable. This is borne out by the findings in six fatal cases.
D000208:Acute Disease; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001784:Blood Gas Analysis; D005934:Glucagon / Q000627:therapeutic use*; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D010179:Pancreas / Q000201:enzymology; D010195:Pancreatitis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality
D005934:Glucagon; D007611:Aprotinin