title: Acute leukemia as a complication of long-term treatment of advanced breast cancer.
abstract: Acute nonlymphocytic leukemia occurred in four women after long-term therapy for advanced breast cancer. The patients had inoperable/metastatic breast cancer that had been well-controlled with chemotherapy for many years (7 years and 4 months, 7 years and 1 month, 6 years and 3 months, and 4 years and 7 months, respectively). Two of the patients had also received extensive radiotherapy. The chemotherapeutic agent that all four patients had received in common was cyclophosphamide.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000628:therapy*; D003520:Cyclophosphamide / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D007953:Leukemia, Radiation-Induced; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D003520:Cyclophosphamide