Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.
Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 muMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 muMol/kg for each one. In soman poisoning no significant reactivation of cholinesterase in serum or erythrocytes was observed.
D000818:Animals; D000931:Antidotes; D001219:Aspartate Aminotransferases / Q000097:blood; D001285:Atropine / Q000627:therapeutic use*; D001535:Benactyzine / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D002802:Cholinesterases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D007928:Lethal Dose 50; D008297:Male; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D012524:Sarin / Q000506:poisoning; D012999:Soman / Q000506:poisoning
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D011726:Pyridinium Compounds; D001535:Benactyzine; D001285:Atropine; D012999:Soman; D012524:Sarin; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D002802:Cholinesterases