Monoamine oxidase inhibiting and toxic effects of acetyl-phenylhydrazide on rat liver in vivo.
For induction of reticulocytosis, rats had been routinely treated with the haemolytic agent, acetyl-phenylhydrazide (APH), and monoamine oxidase (MAO) activity was determined in reticulocytes. Since hydrazines are known to be irreversible inhibitors of MAO, the MAO inhibiting potency of APH was assessed in vitro and in vivo. Only in vivo, an apparently organ-selective MAO inhibition was observed in rat liver; in addition, the rate of recovery of MAO activity in vivo after inhibition with APH was considerably prolonged, indicating a toxic effect of APH on this organ. However, clinical-chemical and pathohistological parameters did not reveal any signs of an overall liver parenchymal cell damage. Hence, a more specific interference of APH with mitochondrial enzyme synthesis must be postulated.
D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D003404:Creatinine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D010659:Phenylhydrazines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013997:Time Factors
D008996:Monoamine Oxidase Inhibitors; D010659:Phenylhydrazines; D003404:Creatinine; D001663:Bilirubin