[The effect of methyl-methacrylate monomer on L-cell metabolism].
The total serum protein synthesis, amino acid assimilation, rate of cell division, and DNA synthesis with various concentrations of methyl methacrylate monomer in medium was determined in a culture of L 929 fibroblasts of the mouse. DNA synthesis was inhibited after 12 hours of incubation. The normal course of cell division was completely supressed with a concentration of 3.2 . 10(-2) mol/l. A decrease in protein synthesis was observed after 24 hours of incubation. This decrease may be considered the result of DNA inhibition.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D007739:L Cells / Q000187:drug effects / Q000378:metabolism*; D008768:Methylmethacrylates / Q000494:pharmacology*; D051379:Mice; D014176:Protein Biosynthesis
D000596:Amino Acids; D008768:Methylmethacrylates; D004247:DNA
Der Einfluss von Methy-Methakrylat-Monomer auf den Stoffwechsel von L-Zellen.