[Formation of antibodies against the antigen-recognizing receptors of T-lymphocytes in a syngenous system].
As shown, formation of antibodies to the antigen-recognition receptors of T-lymphocytes was possible in a syngeneic system. The antiserum of CBA mice given intravenous injections of CBA lymphocytes, immune to C57BL cells, proved to specifically inhibit in a mixed culture blasttransformation of CBA T-lymphocytes only against the C57BL cells. The same antiserum failed to influence the proliferative activity of CBA T-lymphocytes reacting to the "foreign" antigen (DBA/2 cells). No antibodies against the C57BL cells were revealed in the antireceptor antiserum. It is assumed that the autoantireceptor antibodies had a regulatory effect on the immune response.
D000818:Animals; D000961:Antilymphocyte Serum; D001666:Binding Sites, Antibody; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum
Obrazovanie antitel protiv antigenraspoznaiushchikh retseptorov T-limfotsitov v singennoĭ sisteme.