title: Antimicrobial agents and dental caries in the rat.
abstract: Two rat plaque-caries studies indicated that a 0.2% chlorhexidine solution topically applied to rat teeth was effective in reducing dental plaque. This reduction in plaque was accompanied by marked reductions in smooth surface caries, but not in sulcal lesions.
mesh_terms: D000818:Animals; D001645:Biguanides / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D003773:Dental Plaque / Q000517:prevention & control*; D005260:Female; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D051381:Rats
chemical_list: D001645:Biguanides; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds; D002594:Cetylpyridinium; D002710:Chlorhexidine