Serial studies of numbers of circulating T and B lymphocytes in children with acute lymphoblastic leukaemia.
Serial studies of numbers of circulating T and B lymphocytes at monthly intervals in children with acute lymphoblastic leukaemia showed a marked fall in the number of B cells, relatively greater than that of T cells, early in the course of maintenance chemotherapy and immediately after a course of cranial irradiation. The fall in the number of B cell is not a consequence of long-term chemotherapy, and is possibly related to a specific event such as cranial irradiation.
D000208:Acute Disease; D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000628:therapy; D007958:Leukocyte Count; D013601:T-Lymphocytes