Ribonucleic acid synthesis in regenerating liver of irradiated adrenalectomized rats.
The effect of whole-body irradiation on RNA synthesis in regenerating and non-growing livers was studied in intact and adrenalectomized rats. The animals were divided into four sub-groups: (1) control; (2) irradiation only; (3) partially-hepatectomized; and (4) irradiated partially-hepatectomized. Newly-synthesized RNA was determined by 30 or 40 min uptake of (6-14C) orotic acid. Both nuclear and polyribosomal RNA synthesis in regenerating livers of adrenalectomized rats were depressed below their control levels, regardless of whether irradiation was 2 hours before or 2 hours after partial hepatectomy. Specific radioactivity values of regenerating livers of adrenal intact and adrenalectomized rats were elevated above those of the non-growing livers from irradiated and unirradiated rats.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008115:Liver Regeneration / Q000528:radiation effects*; D012313:RNA / Q000096:biosynthesis*; D012335:RNA, Ribosomal / Q000096:biosynthesis; D051381:Rats
D003037:Cobalt Radioisotopes; D012335:RNA, Ribosomal; D012313:RNA