Cancer in families with xeroderma pigmentosum.
In 31 families of xeroderma pigmentosum (XP) patients, significantly more blood relatives than spouse controls had had nonmelanoma skin cancer. These family data support the hypothesis that heterozygosity for XP genes may predispose persons to skin cancer, particularly in association with substantial exposure to sunlight.
D000328:Adult; D000368:Aged; D004260:DNA Repair; D005260:Female; D006579:Heterozygote; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008545:Melanoma / Q000235:genetics; D008875:Middle Aged; D009790:Occupations; D011471:Prostatic Neoplasms / Q000235:genetics; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics; D013472:Sunlight; D014983:Xeroderma Pigmentosum / Q000209:etiology / Q000235:genetics*