title: [Characteristics of the occurrence and development of tumors in rats depending on age and the nature of the strontium-90 exposure].
abstract: In chronic strontium-90 administration into rats aged 8--10 months osteosarcomas did not develop, while in animals at the age of 3--4  months osteosarcomas incidence was 6.7%. In single injection of the radionuclide in 8--10 months old animals osteosarcomas developed in 2.2% of observations, whereas in 3--4 months old animals--in 45.7%. The most early appearance of osteosarcomas (at the 193d--316th day) was noted in 3--4 months old animals subjected to a single exposure to strontium-90.
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000209:etiology*; D012516:Osteosarcoma / Q000209:etiology; D051381:Rats; D013326:Strontium Radioisotopes / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D013326:Strontium Radioisotopes
vernacular_title: Nekotorye osobennosti vozniknoveniia i razvitiia opukhole i krys v zavisimosti ot vozrasta i kharaktera vozdeĭstviia strontsiem-90.