Binding of synthetic anabolic steroids to testosterone-estradiol binding globulin and to rat prostate cytosol.
The binding of five synthetic anabolic steroids and two natural androgens to testosterone-estradiol binding globulin (TeBG) and to cytoplasmic fraction containing androgen receptors from prostates of castrated rats was compared. The binding affinity to TeBg decreased in sequence: dihydrotestosterone--testosterone--methyltestosterone-methandienone--nortestosterone--dimethylandrostanolone--nortestosterone--phenylpropionate (no binding); in the prostatic cytosol the following fecreasing sequence was found: dihydrostestosterone--methyltestosterone--methandienone--nortestosterone--nortestosterone phenylpropionate--testosterone--dimethylandrostanolone. The law binding to TeBG of 17alpha-methylated steroids possessing at the same time high affinity to cytoplasmic receptors may enhance their effect in target tissues.
D045930:Anabolic Agents / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D003600:Cytosol / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D045930:Anabolic Agents; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol