In vitro uptake of L-dopa and catecholamines into the epidermal Langerhans cell.
The Langerhans cells are capable of taking up L-dopa and the catecholamines dopamine and noradrenaline when exposed to these substances in vitro. Within the cell L-dopa is found in the cytoplasm as well as in the nucleus, whereas the catecholamines are confined to cytoplasmic granules. The L-dopa uptake is most probably carrier-mediated and the hypothesis is brought forward that L-dopa enters the cell by exchange diffusion. At present little is known about the nature of the amine uptake mechanism.
D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D000078404:Epidermal Cells; D006801:Humans; D007801:Langerhans Cells / Q000378:metabolism*; D007980:Levodopa / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000378:metabolism*
D007980:Levodopa; D004298:Dopamine; D009638:Norepinephrine