title: The effect of adrenaline, insulin and hydrocortisone on human peripheral blood lymphocytes studied by cell surface markers.
abstract: Changes in numbers of peripheral blood lymphocytes from healthy individuals were calculated from samples collected before and after parenteral administration of adrenaline, insulin and hydrocortisone, respectively. A marked increase in circulating lymphocytes was noted in response to adrenaline and insulin. However, subpopulation analysis showed a decrease in the proportion of T-lymphocytes, estimated as cells forming rosettes with sheep red blood cells after incubation in the cold and a corresponding increase in proportion of lymphocytes having receptors for C3 (non-T lymphocytes). In contrast, lymphocyte numbers were unaffected by hydrocortisone. The results indicate that a decreased proportion of circulating T-lymphocytes and an increase of non-T-lymphocytes may be the result of adaptive changes in response to various forms of stress and hence is to be expected in several clinical conditions.
mesh_terms: D000328:Adult; D002462:Cell Membrane / Q000276:immunology; D003176:Complement C3; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects*; D011955:Receptors, Drug; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D003176:Complement C3; D007328:Insulin; D011955:Receptors, Drug; D006854:Hydrocortisone; D004837:Epinephrine