Cytotoxic T cells specific for influenza virus-infected target cells.
Conditions are described for the generation and detection of murine cytotoxic cells which lyse influenza virus-infected target cells. A number of criteria indicated that most and probably all of the activity was due to T cells. These criteria included the susceptibity of cytotoxic activity to treatment with anti-theta ascitic fluid plus complement and the enhancement of lysis when there was H2 compatibility between donors of effector and virus-infected target cells.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001202:Ascitic Fluid / Q000276:immunology; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D003165:Complement System Proteins