[Inhibitors of trypsin-like proteolytic enzymes as means of preventing  the development of secondary necrosis in burn wounds].
The effect of proteolytic inhibitor contrical on the experimental burn wound healing was studied in rats using biochemical, histological and histochemical methods. In control untreated animals with flame burn of 20% of body surface wound healing was associated with development of secondary necrosis, marked inflammatory reaction, augmented activity of proteases and peptidases. The use of contrical prevented secondary necrosis; this effect was apparently related to reduction of tissue proteolytic enzymes activity.
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D009336:Necrosis / Q000517:prevention & control; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000201:enzymology / Q000293:injuries*; D014945:Wound Healing
D007611:Aprotinin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010447:Peptide Hydrolases
Ingibitory tripsinopodobnykh proteoliticheskikh fermentov kak sredstva, prepiatstvuiushchie razvitiiu vtorichnogo nekroza v ozhogovoĭ rane.