Aberrant blastogenic response to LPS in experimental gingivitis of elderly subjects.
The blastogenic response of peripheral blood leukocytes to lipopolysaccharide (LPS), phytohemagglutinin (PHA) and LPS/PHA mixtures was followed over a short course of experimental gingivitis in elderly subjects (65-81 years) who strictly avoided oral hygiene procedures for periods up to 9 d. The leukocytes responded poorly to LPS, PHA and to LPS/PHA combinations. The concomitant heightened sensitivity of the gingiva to dental plaque among the elderly subjects may relate to the altered leukocyte response in this age group.
D000368:Aged; D001757:Blastomeres / Q000187:drug effects / Q000276:immunology; D003773:Dental Plaque / Q000276:immunology; D005260:Female; D005891:Gingivitis / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology
D008070:Lipopolysaccharides; D010835:Phytohemagglutinins