Redistribution of regional blood flow after administration of saralasin in salt-depleted dogs.
1. Salt depletion was produced in five dogs by a low salt diet and daily administration of frusemide for 5 days; a control group of five dogs was placed on the same diet, to which 2.5 g of sodium chloride was added. 2. Saralasin infusion (0.5 microgram min-1 kg-1) reduced mean aortic blood pressure and total peripheral vascular resistance and increased cardiac output in salt-depleted dogs, but did not affect the heart rate and left ventricular dP/dt. 3. Saralasin infusion increased mean aortic blood pressure slightly in normal dogs; other systemic haemodynamic parameters did not change significantly. 4. Saralasin decreased hepatic arterial flow in both normal and salt-depleted dogs, but increased blood flow to left ventricle and kidneys only in salt-depleted dogs. 5. These results suggest that saralasin exerts a partial agonist effect in normal dogs to increase arterial blood pressure, but causes a depressor response during salt depletion because it reverses the vasoconstrictor effect of angiotensin II, particularly on the renal and coronary circulations.
D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects*; D012504:Saralasin / Q000494:pharmacology*; D012965:Sodium Chloride / Q000378:metabolism
D000804:Angiotensin II; D012965:Sodium Chloride; D005665:Furosemide; D012504:Saralasin