Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.
The dominant C57BL/10 allele of a single autosomal, non-H-2 gene (Rfv-3) was found to be required for recovery from viremia and leukemia induced by Friend virus complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response.
D000818:Animals; D002874:Chromosome Mapping; D005622:Friend murine leukemia virus; D005796:Genes; D008040:Genetic Linkage; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood / Q000235:genetics / Q000382:microbiology; D007942:Leukemia, Experimental / Q000097:blood / Q000235:genetics* / Q000382:microbiology; D051379:Mice