Thymus-dependent lymphocytes and delayed hypersensitivity in low birth weight infants.
The proportion of thymus-dependent (T) lymphocytes in the blood and the ability to mount cutaneous delayed hypersensitivity to a battery of antigens were evaluated in 50 low birth weight (LBW) infants when they were 3 months to 5 years old. There was a significant reduction in the number of T lymphocytes. Delayed hypersensitivity was impaired. The abnormalities were more pronounced in those with persistent growth retardation. It is suggested that continued postnatal depression of cell-mediated immunity in LBW infants may contribute to increased frequency of infections and immunopathological diseases.
D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*