Activation of the kallikrein-kinin system in bullet wounding.
Anesthetized pigs were wounded in the thigh with a spherical missile at an impact velocity of 1500 m/sec. Arterial blood samples were taken before injury and at frequent intervals up to 12 hours after injury. Unbound (free) and total kallikrein (kallikrein + prekallikrein) were analyzed with a chromogenic substrate (S-2302, Kabi, Sweden) in which enzyme activity is determined spectrophotometrically by the development of a yellow colour. The results indicate an activation of the kallikrein-kinin system in bullet wounding, the significance of which remains to be determined.
D000818:Animals; D004789:Enzyme Activation; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D011288:Prekallikrein / Q000097:blood; D013053:Spectrophotometry; D013552:Swine; D013848:Thigh / Q000293:injuries; D014948:Wounds, Gunshot / Q000097:blood / Q000201:enzymology*
D007705:Kinins; D011288:Prekallikrein; D007610:Kallikreins