[Immunological membrane markers in blasts and lymphocytes of patients with acute leukemia].
Acute lymphoblastic leukemia can be subdivided into groups with different prognoses and clinical courses by immunological cell-markers. Patients with blasts, expressing T-cell-markers in a high density (T-cell leukemia), had an increased incidence of meningeal relapses, tumor formation in abdomen or mediastinum. T-lymphoblastic lymphoma is the same disease only different in initial presentation. After combination chemotherapy over one year, lymphocytes populations with no immunological cell-markers are relatively increased. Regular monitoring of the immunological subgroups of lymphocytes seems to be unhelpful in early diagnosis of periods with increased risk of severe infections.
D001402:B-Lymphocytes / Q000276:immunology; D001665:Binding Sites; D002051:Burkitt Lymphoma / Q000209:etiology; D002460:Cell Line; D002462:Cell Membrane; D004731:Endotoxins / Q000627:therapeutic use; D006801:Humans; D007072:Immunoglobulin D; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M; D007938:Leukemia / Q000188:drug therapy / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000175:diagnosis; D008727:Methotrexate / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*
D004731:Endotoxins; D007072:Immunoglobulin D; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M; D008727:Methotrexate
Immunologische Membranmerkmale auf Blasten und Lymphozyten von Patienten mit akuter Leukämie.