Thiamin deprivation in ventromedial hypothalamic hyperphagic rats: anorexia, specificity of food aversion, and a dietary consideration.
The anorexic consequence of thiamin deprivation was investigated in ventromedial hypothalamic (VMH) hyperphagic rats under either high-fat or low-fat thiamin-free diet conditions. The low-fat diet maintained feeding significantly longer in thiamin-deprived VMH rats than in intact rats, whereas the hig-fat diet sustained feeding in thiamin-deficient intact rats and accelerated anorexia onset in vitamin B1 deprived VMH rats. This effect was noted under both ad lib and pair-feeding conditions. Thiamin-deprived VMH rats subjected to weight control developed anorexia sooner than intact subjects regardless of the diet employed. The VMH rats fed a high-fat diet failed to resume feeding after thiamin readministration, which was interpreted as a permanent aversion to this diet. The relation between dietary intake and conditioned taste aversion is discussed with reference to the VMH and intact rat.
D000818:Animals; D000855:Anorexia / Q000209:etiology*; D001362:Avoidance Learning / Q000502:physiology; D001927:Brain Diseases / Q000150:complications; D004041:Dietary Fats / Q000008:administration & dosage; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005518:Food Preferences; D006801:Humans; D007031:Hypothalamus; D007033:Hypothalamus, Middle / Q000502:physiology; D008297:Male; D051381:Rats; D013832:Thiamine Deficiency / Q000150:complications*
D004041:Dietary Fats