Elevation of serum 25-hydroxycalciferol levels in androgen-treated and ultraviolet-irradiated rats.
Administration of 4-8 mg testosterone propionate significantly raised 25-hydroxycalciferol levels in the ultraviolet irradiated rats compared to the ultraviolet irradiated controls, but failed to influence serum 25-hydroxycalciferol levels in the non-irradiated animals. Estradiol benzoate and progesterone did not influence serum 25-hydroxycalciferol levels regardless of the ultraviolet irradiation. These findings implicate that testosterone enhances vitamin D biosynthesis induced by ultraviolet irradiation in rats, in accordance with the clinical observation that males often show higher levels of serum 25-hydroxycalciferol than females.
D000818:Animals; D002118:Calcium / Q000097:blood; D004872:Ergocalciferols / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006887:Hydroxycholecalciferols / Q000097:blood*; D008297:Male; D051381:Rats; D012867:Skin / Q000528:radiation effects; D013739:Testosterone / Q000494:pharmacology*; D014466:Ultraviolet Rays
D004872:Ergocalciferols; D006887:Hydroxycholecalciferols; D013739:Testosterone; D002118:Calcium