title: Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
abstract: Mice can be protected against the toxicity arising from lethal doses of methotrexate with purine and pyrimidine combinations, but not with pyrimidine alone. Furthermore, methotrexate treatment of tumour-bearing mice, conjunction with purine/pyrimidine protection, can be more effective than conventional metotrexate/folinic acid treatment.
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D004357:Drug Synergism; D005260:Female; D007042:Hypoxanthines / Q000627:therapeutic use; D007288:Inosine / Q000627:therapeutic use; D002955:Leucovorin / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011687:Purines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D013936:Thymidine / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D007042:Hypoxanthines; D011687:Purines; D011743:Pyrimidines; D007288:Inosine; D000493:Allopurinol; D002955:Leucovorin; D013936:Thymidine; D008727:Methotrexate