title: [On the antipyretic effect of paracetamol. Clinical investigation with two different forms of application (author's transl)].
abstract: 144 children, aged between 15 days and 12 years, suffering from febrile condition of various etiology, were treated with differentiated single doses of paracetamol (N-acetyl-p-aminophenol) in form of syrup, suppositories and a combination of syrup with the antihistamine doxylaminsuccinate. During investigation periods of four hours, applying reduced doses, the syrup application showed the same antipyretic effects as those obtained with paracetamol suppositories. When administering the combination with doxylaminsuccinate, the antipyretic effect was reduced and the psychomotoric superactivity did not improve. A control of the actual rectal dosage scheme for repetitive applications is recommended and the combination of paracetamol with sedatives is to be discussed.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002648:Child; D002675:Child, Preschool; D004304:Dosage Forms; D004319:Doxylamine / Q000627:therapeutic use; D004347:Drug Interactions; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D013488:Suppositories
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004304:Dosage Forms; D013488:Suppositories; D000082:Acetaminophen; D004319:Doxylamine
vernacular_title: Zum antipyretischen Effekt von Paracetamol. Klinische Untersuchung mit zwei unterschiedlichen Applikationsformen.