title: Microsomal vinyl oxide synthetase: modification of its kinetic parameters by chemical carcinogens.
abstract: The kinetic parameters of liver microsomal vinyl oxide synthetase as well as their modifications under the influence of various pretreatments have been evaluated, using 1,1,2-trichlorethylene (TCE) as a substrate. The results were correlated with those obtained using aldrin oxide synthetase and benzpyrene hydroxylase as typical cytochrome P-450 dependent enzymatic activity. The treatments of animals with chemical carcinogens selectively increase the affinity of those enzymes for their substrates.
mesh_terms: D000452:Aldrin / Q000378:metabolism; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D002273:Carcinogens / Q000494:pharmacology*; D004852:Epoxy Compounds; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D014241:Trichloroethylene; D014753:Vinyl Compounds
chemical_list: D002273:Carcinogens; D004852:Epoxy Compounds; D014753:Vinyl Compounds; D014241:Trichloroethylene; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D001579:Benzopyrene Hydroxylase; D000452:Aldrin