Enhanced reaginic antibody formation to ovalbumin in mice given repeated injections of concanavalin A.
Mice injected with 4 weekly doses of concanavalin A arabinogalactan complex (Con A-AG) give a secondary type of IgE response when they encounter ovalbumin (Ov) for the first time. The IgE-enhancing effect of Con A-AG immunization applies to Ov but not to various other antigens. However, no cross-reaction appears to exist at the humoral level between Con A and Ov. The apparent priming of mice to Ov by Con A can be adoptively transferred to syngeneic irradiated recipients by spleen cells.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D003208:Concanavalin A / Q000008:administration & dosage / Q000494:pharmacology*; D003429:Cross Reactions; D004334:Drug Administration Schedule; D005260:Female; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008934:Mitogens; D010047:Ovalbumin / Q000276:immunology*; D011134:Polysaccharides / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000941:Antigens; D008934:Mitogens; D011134:Polysaccharides; D003208:Concanavalin A; D007073:Immunoglobulin E; D010047:Ovalbumin