Studies on the product of antigenic recognition. II. Formation of the product in recognition of alloreceptors.
Cell-bound or shed T-lymphocyte receptors for alloantigens and the IgG-associated, alloantigen-recognizing principle in T alloantiserum reacted with antisera raised against those structures to form a product of antigenic recognition (PAR) in which the receptor or its equivalent took the role of 'antigen'. Formation of PAR was tested for numerous combinations of reactants and in all the process was completed within 1-2 h at 37 or 4 degrees C. Cell-bound receptors were found to be solubilized by all three forms of antisera, with the exception of an antiserum lacking anti-T-receptor activity. The data indicated that PAR might be a complex of antigen and antibody with granulotactic activity whose formation was specific.
D000818:Animals; D001666:Binding Sites, Antibody; D002474:Cell-Free System; D005260:Female; D007106:Immune Sera; D007156:Immunologic Memory; D007518:Isoantibodies; D007519:Isoantigens; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
D007106:Immune Sera; D007518:Isoantibodies; D007519:Isoantigens