Intravitreal amphotericin B treatment of Candida endophthamitis.
A 43-year-old heroin addict with Candida albicans endophthalmitis was treated with a single 5-mug intravitreal injection of amphotericin B. The diagnosis was confirmed by smears and cultures of a vitrous aspiration. The patient's accidental death seven weeks after treatment enabled us to obtain histopathologic evidence that the infection had been cured and that the amphotericin B had had no toxic effect on the retina. Intravitral amphotericin B should be considered an important mode of treatment of Candida endophthalmitis.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D010633:Phenmetrazine; D019966:Substance-Related Disorders / Q000150:complications; D014792:Visual Acuity
D000666:Amphotericin B; D010633:Phenmetrazine