Myeloschisis in a six weeks embryo of a leukemic woman treated by busulfan.
A case of myeloschisis in a six weeks old human embryo is reported. The 39-year-old mother was treated by busulfan before and during the early stages of gestation for chronic lymphatic leukemia. Additional histological findings consisted in a decrease of mesenchymal elements together with a somitic disorganisation in the affected area of the embryo. In spite of the well known experience that this drug is well tolerated by leukemic pregnant women, a possible interference of busulfan with the oocyte differentiation in this elderly primipara is proposed.
D000014:Abnormalities, Drug-Induced; D000032:Abortion, Therapeutic; D002066:Busulfan / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013116:Spinal Cord / Q000002:abnormalities*
D002066:Busulfan