Modification of factor VIII complex properties in patients with liver disease.
Factor VIII procoagulant activity (VIII:C), factor VIII related antigen (VIIIR:AG), and the von Willebrand factor (VIII:WF) were measured in 19 patients with liver disease (8 cases of alcoholic cirrhosis and 11 with acute viral hepatitis). In both groups of patients the levels of VIII:C, VIIIR:AG, and VIIIR:WF were above normal or normal with mean values well above the normal range. VIIR:AG was also measured in the same patients by two-dimensional electrophoresis, and its biological properties were measured after purification by chromatography. By both methods the VIIIR: AG in the patients with liver disease differed from normal VIIIR:AG. In five of the patients with acute viral hepatitis, who were tested after they had recovered, the previously elevated levels of VIII:C, VIIIR:AG, and VIIIR:WF had dropped to normal limits and the qualitative abnormalities had disappeared.
D000941:Antigens / Q000032:analysis; D005169:Factor VIII / Q000032:analysis*; D006525:Hepatitis, Viral, Human / Q000097:blood; D006801:Humans; D007122:Immunoelectrophoresis; D008103:Liver Cirrhosis / Q000097:blood; D008107:Liver Diseases / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII