title: [ZNS complications in children with acute lymphatic leukemia. Computer tomographic studies].
abstract: 78 children with acute lymphoblastic leukemia or non-Hodgkin-lymphoma were treated at the Children's Hospital of the University of Heidelberg from December 1971 to April 1979. Following cytostatic treatment and irradiation of the skull 11 children developed CNS-symptoms (mainly seizures and paresis) which were caused by intracerebral hemorrhage, infectious or degenerative CNS-diseases. Cranial axial tomography (CAT) was helpful in finding the cause of the CNS-complication. We recommend routine CAT in the beginning and during the course of treatment of leukemia to document CNS-changes as early as possible and to prevent further damage by alterations of therapy.
mesh_terms: D000293:Adolescent; D001922:Brain Abscess / Q000209:etiology; D002114:Calcinosis / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D008223:Lymphoma / Q000150:complications; D008727:Methotrexate / Q000627:therapeutic use; D010243:Paralysis / Q000209:etiology; D012075:Remission, Spontaneous; D012640:Seizures / Q000209:etiology*; D013344:Subacute Sclerosing Panencephalitis / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D008727:Methotrexate
vernacular_title: ZNS-Komplikationen bei Kindern mit akuter lymphatischer Leukämie. Computer-tomographische Untersuchungen.