[Autoradiographic study of the activity of odontoblasts and secretory ameloblasts in the rat incisor: changes induced by vinblastine].
An autoradiographic study conducted on the rat incisor showed the presence 4 hours after (3H) proline injection, of 25-30% of the grains on the secreting cells and 70 to 75% on the extracellular matrics. The simultaneous injection of vinblastine sulphate reversed these percentages to 75-80% on the cellular level and 25-25% on the matrics. The vinblastine therefore inhibited the secretory processes of these cell types. On the other hand, due to the alkaloid, the number of grains present increased over the ameloblasts and principally over the intercellular spaces. The effects of these secretion and permeability variations suggested that a flow of precursor rich material reached the epithelial layer whatever the state of ameloblast activity.
D000565:Ameloblasts / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D003743:Dental Enamel / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D007180:Incisor / Q000187:drug effects* / Q000378:metabolism; D009804:Odontoblasts / Q000187:drug effects* / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D051381:Rats; D014316:Tritium; D014747:Vinblastine / Q000494:pharmacology*
D014316:Tritium; D014747:Vinblastine; D011392:Proline
Etude autoradiographique de l'activité des odontoblastes et des améloblastes sécréteurs de l'incisive de rat: modifications induites par la vinblastine.