Giant-cell pneumonia and lung tumorlets in a leukemic four-year-old child.
The authors report a case of a 4-year-old child whose death resulted from acute lymphoblastic leukemia (ALL) and giant-cell pneumonia. Typical lung tumorlets were occasionally observed. On electron microscopy study it was possible to demonstrate a large number of neurosecretory granules in the tumorlet's cells, identical to those present in Kulchitsky's cells. These studies suggest the occurrence of an abnormal immunitary process.
D002675:Child, Preschool; D006801:Humans; D007165:Immunosuppression Therapy; D007945:Leukemia, Lymphoid / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications* / Q000209:etiology / Q000473:pathology; D008459:Measles virus; D009378:Neoplasms, Multiple Primary / Q000150:complications*; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000209:etiology / Q000473:pathology