Probabilities of concordance of twins with respect to genetic markers. A general formulation.
The formulas needed in the determination of monozygosity in twin pairs using genetic markers are derived and presented. A general formula for the calculation of concordance probabilities independent of gene frequencies and allele number is derived, enabling either manual computation or computer programming for any Mendelian markers usable in twin zygosity diagnosis.
D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D009874:Operations Research; D011247:Pregnancy; D011338:Probability Theory; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D005819:Genetic Markers