Prostaglandins in maternal and fetal plasma and in allantoic fluid during the second half of gestation in the mare.
The concentrations of the primary prostaglandins (PG) F-2alpha and E-2 and the metabolite 13,14-dihydro-15-oxo-prostaglandin (PGFM) in maternal and fetal plasma and in allantoic fluid were measured in chronically catheterized mares and fetuses. A gradual rise in all 3 PGs occurred with increasing gestational age. PGE-2 and PGF-2 alpha levels were highest in the allantoic fluid and lowest in the maternal plasma, whereas PGFM concentrations were greatest in maternal plasma. Significant venous-arterial plasma differences in PGFM concentration were detected across the uterine circulation between 180 and 280 days gestation. The 3--5-fold rise in maternal PGFM associated with fasting or intrauterine surgery was virtually abolished by meclofenamic acid, a prostaglandin synthetase inhibitor. Increases in PGE-2 and PGF-2 alpha in the fetal fluids preceded premature delivery of the foal, while PG changes in maternal plasma were minimal even 10--20 h before delivery.
D000482:Allantois / Q000378:metabolism; D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005508:Food Deprivation; D005865:Gestational Age; D006736:Horses / Q000502:physiology*; D007743:Labor, Obstetric; D011247:Pregnancy; D011270:Pregnancy, Animal; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F