Correlation between local oxygen tension in muscle tissue and survival time in tourniquet shock.
Tourniquet shock was induced in rabbits by constricting one hind leg for 4 hr. Local pO2 on muscle surface was measured by a multiwire platinum electrode according to the method of Kessler. Untreated animals showed anoxic tissue areas after a period of 30 min of reperfusion. All these animals died in shock within 3-4 hr. The glucocorticoid, prednisolone (20 mg/kg), and the proteinase inhibitor, Trasylol (20,000 KIU/kg), were administered 5 min bfore release of the tourniquet. These animals showed normal pO2 values during the 2-3 hr observation period. Tourniquet shock was prevented and survival time prolonged by these agents. This protective effect could be correlated to the oxygen tension in the ischemic region.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D006614:Hindlimb / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D010101:Oxygen Consumption; D011239:Prednisolone / Q000627:therapeutic use; D011817:Rabbits; D012769:Shock / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors
D007611:Aprotinin; D011239:Prednisolone