Another approach to in vivo estimation of genetic damage in humans.
Direct measurements of the genetic hazards to man have been determined previously by the appearance of elevated in vivo levels of chromosome aberrations. Here we report that interindividual variations in N-acetoxy-2-acetyl-aminofluorene-induced unscheduled DNA synthesis values parallel the actual in vivo levels of chromosome damage and, therefore, may be a rapid useful supplement in genetic risk assessment for humans.
D015073:2-Acetylaminofluorene; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens
D009153:Mutagens; D004247:DNA; D015073:2-Acetylaminofluorene