title: Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.
abstract: Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.
mesh_terms: D000818:Animals; D004260:DNA Repair; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D008677:Metaphase; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens; D010063:Ovum / Q000502:physiology*; D013087:Spermatids / Q000502:physiology; D013094:Spermatozoa / Q000502:physiology*
chemical_list: D009153:Mutagens