Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid.
The synthesis of the 2,4-diamino analogue of riboflavin is described. Inhibition analysis in a microbial assay system indicated that this compound has a weak antifolate activity that could be overcome with a minimal amount of folinic acid, but at higher concentrations both folinic acid and riboflavin were required for the reversal of its inhibitory effect.
D003864:Depression, Chemical; D005493:Folic Acid Antagonists / Q000138:chemical synthesis; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development; D002955:Leucovorin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D005493:Folic Acid Antagonists; C014052:2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin; D002955:Leucovorin; D012256:Riboflavin