Effects of nitrous oxide during organogenesis in the rat.
Susceptibility of the pregnant female rat to possible teratogenic effects from acute nitrous oxide exposure was studied. A statistically significant increase in fetal death rate (ranging from 19.1 to 7%) was observed with exposure during various periods of organogensis. No significant differences in fetal length, weight, or organ-to-body-weight ratio for spleen and liver were observed.
D000766:Anesthesia, Dental / Q000009:adverse effects; D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D009609:Nitrous Oxide / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D013723:Teratogens
D013723:Teratogens; D009609:Nitrous Oxide