Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides.
The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.
D000818:Animals; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008968:Molecular Conformation; D009584:Nitrogen; D009705:Nucleosides / Q000378:metabolism / Q000627:therapeutic use*; D010100:Oxygen; D011955:Receptors, Drug / Q000378:metabolism; D013329:Structure-Activity Relationship
D009705:Nucleosides; D011955:Receptors, Drug; D009584:Nitrogen; D010100:Oxygen