The intracellular enzymatic response of neutrophils and lymphocytes in patients with precancerous states and cancer of the larynx.
In patients with precancerous states and cancer of the larynx prior to and after radiotherapy exhibit the decreased activity of neutrophil beta-glucuronidase. Moreover patients treated by radiotherapy before the age of 6 to 9 years demonstrate deficiency of N-acetyl-beta-glucosaminidase in the above cells. The main finding in lymphocytes of the patients studied was in the appearance by diffusion of the above enzymes and of acid phosphatase in the cytoplasm, reflecting their release from lysosomes and immunological mobilization of these cells. The authors discuss the possible role of neutrophil enzymatic deficiency in lowering the antitumour cytotoxic effect of these cells.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000328:Adult; D000368:Aged; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000276:immunology / Q000532:radiotherapy; D007958:Leukocyte Count; D008214:Lymphocytes / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D011230:Precancerous Conditions / Q000201:enzymology* / Q000276:immunology / Q000532:radiotherapy
D000135:Acid Phosphatase; D005966:Glucuronidase; D000118:Acetylglucosaminidase