Loss of surface IgD by human B lymphocytes during polyclonal activation.
Surface and cytoplasmic immunoglobulins were studied by direct immunofluorescence in pokeweed mitogen-stimulated cultures of human blood lymphocytes. The results compared to those of studies of unstimulated cultures and of fresh normal lymphocytes showed a striking decrease in surface IgD during terminal maturation of B lymphocytes into plasma cells. The number of cells which expressed IgG Fe receptor also decreased, although to a lesser extent.
D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007072:Immunoglobulin D; D007141:Immunoglobulin Fc Fragments / Q000032:analysis; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*
D007072:Immunoglobulin D; D007141:Immunoglobulin Fc Fragments; D037102:Lectins; D011947:Receptors, Antigen, B-Cell