[T (15;17) translocation in acute promyelocytic and acute nonpromyelocytic leukemia (author's transl)].
Seven acute promyelocytic leukemias (APL) were compared with three atypical acute myeloblastic leukemias (AML). These three AML were characterized by high hyperleukocytosis, mostly formed of monocytelike myeloblasts, disseminated intravascular coagulation syndrome, and a t (15;17) translocation in the majority of leukemic cell mitoses. This translocation was inconsistently found in typical APL defined as M3, according to the FAB classification.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D002648:Child; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure*; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics* / Q000648:ultrastructure; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
Translocation t (15;17), leucémie aiguë promyélocytaire et non promyélocytaire.