Clinical and immunological studies on healthy blood donors hepatitis B antibody carriers.
Ten healthy blood donors persistently seropositive for anti-HBs and without a history of clinically overt viral hepatitis were studied. While physical examination and biochemical liver function tests exhibited normal values in all cases, immunologic studies revealed coexistence of a long-term anti-HBs carrier state with the presence of cell-mediated immunity to HBV antigens and autoantibodies in some. These results suggest a complex immunologic phenomenon underlying the development of the anti-HBs carrier state.
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001782:Blood Donors; D002353:Carrier State; D002464:Cell Migration Inhibition; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008928:Mitochondria; D009130:Muscle, Smooth
D000906:Antibodies; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006510:Hepatitis B Antibodies