title: Enhancement of local tumour control by misonidazole and hyperthermia.
abstract: Combination treatment of a C3H mammary carcinoma with misonidazole, hyperthermia and radiation resulted in greater local tumour control than with any of these agents singly or in pairs. Dose modification factors for the 3-fold combinations were 3.28 when tumours were immersed in a 42.5 degree C waterbath for 1h after irradiation, and 5.03 at 43.0 degrees C. Cytotoxicity of misonidazole alone was slight, as reflected histologically and in tumour growth. Hyperthermia had a marked effect on these two parameters. Foot damage by hyperthermia was greatest when feet were taped.
mesh_terms: D000818:Animals; D005260:Female; D006358:Hot Temperature / Q000627:therapeutic use*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents
chemical_list: D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents