[Immunology and immunotherapy of leukemia (basic results of 8-years research)].
In the paper, the main results of some investigations, conducted in the Institute laboratories during 1969--77, are summarized. Special attention is given to the detected first phenomenon of functional antagonism of antibodies in leukemia and to the recognition of the specific humoral immune responsiveness of acute leukemia patients. The author reports the results of clinical trials of "the method for regulation of the specific immunity", which practically gives a 100% remission in comparatively short terms for children with acute lymphoblastic leukemia. Also, a longer remission term and survival were gained in children, subjected in the remission period to chemotherapy in combination with BCG injections as compared with patients treated only by chemotherapy.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis; D000917:Antibody Formation; D001500:BCG Vaccine / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007942:Leukemia, Experimental / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000628:therapy; D051379:Mice; D011239:Prednisolone / Q000627:therapeutic use; D011925:Rauscher Virus
D000912:Antibodies, Neoplasm; D001500:BCG Vaccine; D007075:Immunoglobulin M; D011239:Prednisolone
Immunologiia i immunoterapiia leĭkoza (osnovnye rezul'taty 8-letnikh issledovaniĭ.