Influence of age and cortisone treatment on two intestinal lysosomal hydrolases in young rats.
The effects of cortisone acetate injected i.p. on acid phosphatase and beta-glucuronidase in the small intestine mucosa of two groups of rats aging 12-14 and 20-22 days are reported. The following results are obtained: a) Total and free activities of the two enzymes show age-dependent differences. b) Cortisone acetate causes a very marked decrease of the enzymic activities only in the younger rats while being ineffective on the older ones. c) The kinetics of the enzyme release at 37 degrees C appear independent either of age or of cortisone injection. d) The "in vitro" lysosome labilizing treatments are ineffective.
D000135:Acid Phosphatase / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003348:Cortisone / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D051381:Rats
D000135:Acid Phosphatase; D005966:Glucuronidase; D003348:Cortisone