Effects of topically-applied olive oil on the response of hamster skin to single or multiple doses of 230kV X-rays.
The effects of topically-applied olive oil on the response of hamster skin to single or multiple doses of X-rays has been studied. The olive oil was applied either 15 min or 1 hour before the radiation exposures. The treatment did not alter the temporal pattern of development and recovery from the radiation injury. For single exposers, olive oil did not alter the 1- to 30-day average skin response. However, when it was administered at each treatment when three radiation fractions were given over a 4-day interval (3 fractions/4 days), a significant increase in the amount of dose recovered was found compared with control irradiated animals. For controls, the average amount of dose recovered per fractionation interval, (Dn-D1)/(n-1), was about 505 rad. For animals treated with olive oil 15 min before irradiation, it was about 720 rad; and for those treated 1 hour before irradiation, it was 782 rad. The data indicate a definite radioprotective effect of topical administration of olive oil, but at present the mechanism is not known.
D000287:Administration, Topical; D000818:Animals; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D005260:Female; D009821:Oils / Q000008:administration & dosage* / Q000627:therapeutic use; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011855:Radiodermatitis / Q000517:prevention & control*; D013997:Time Factors; D014965:X-Rays
D009821:Oils; D011837:Radiation-Protective Agents