Increased immune response in the acute phase of systemic lupus erythematosus and psoriatic arthritis caused by serum factors.
In the acute phase of systemic lupus erythematosus the serum contains factors, with molecular weights ranging from 780,000 daltons to 1.5 million daltons, which induce blast transformation of autologous lymphocytes. In addition to the high-molecular weight components, low-molecular weight factors (75,000 and 160,000 daltons) which also induce an increase in lymphocytic transformation have also been demonstrated. In contrast to the high-molecular weight components the low-molecular factors stimulate the transformation of autologous and homologous lymphocytes. During transformation, lysis of autologous target fibroblasts occurs. The low-molecular weight mitogenic components remain stable after 30 min at 56 degrees C. The significance of such mediators for the pathogenesis of systemic lupus erythematosus is discussed.
D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex; D001168:Arthritis / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008970:Molecular Weight; D011565:Psoriasis / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex