AKR T-cell acute lymphoblastic leukemia: a model for human T-cell leukemia.
In humans, the T cell form of acute lymphoblastic leukemia has proved to be a difficult therapeutic challenge; long-term remissions are unusual. Spontaneous T cell leukemia of AKR mice bears many similarities to the human disease and is proposed as an experimental model in which to test treatment strategies prior to clinical trial.
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D051379:Mice; D008806:Mice, Inbred AKR; D012376:Rodent Diseases / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*