Effect of salt solutions on radiosensitivity of mammalian cells. I. Specific ion effects.
The radiation isodose survival curve of cells subjected to a wide concentration range of sucrose solutions has two maxima separated by a minimum. Both cations and anions can alter the cellular radiosensitivity above and beyond the osmotic effect observed for cells treated with sucrose solutions. The basic shape of the isodose curve can also be modulated by changes in temperature and solution exposure times. Some of these alterations in radiosensitivity may be related to changes in the amount and structure of cellular water or macromolecular conformation or to the direct effect of the ions, expecially at high solute concentrations.
D000085:Acetates / Q000494:pharmacology; D000643:Ammonium Chloride / Q000494:pharmacology; D001464:Barium / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects*; D002588:Cesium Radioisotopes; D002704:Chlorates / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D005720:Gamma Rays; D008094:Lithium / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D009566:Nitrates / Q000494:pharmacology; D009994:Osmolar Concentration; D011189:Potassium Chloride / Q000494:pharmacology; D011836:Radiation Tolerance; D012492:Salts / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013431:Sulfates / Q000494:pharmacology
D000085:Acetates; D002588:Cesium Radioisotopes; D002704:Chlorates; D002712:Chlorides; D002951:Citrates; D009566:Nitrates; D012492:Salts; D013431:Sulfates; D000643:Ammonium Chloride; D001464:Barium; D012965:Sodium Chloride; D011189:Potassium Chloride; D008094:Lithium; D012964:Sodium; D008274:Magnesium; D002122:Calcium Chloride