Pulmonary metastases from autochthonous 3-methylcholanthrene-induced murine tumors.
In three experiments, 87%, 75%, and 85% of female C57BL/6N mice developed pulmonary metastases by 50 days after amputation of legs having autochthonous 3-methylcholanthrene-induced sarcomas. No difference in the incidence of pulmonary metastases was observed when autochthonous tumors of short (49--94 days) and longer (95--119 days) latency periods were compared. These metastasizing autochthonous tumors may provide a useful model for studies of metastases and for the evaluation of cancer therapy in a minimal residual disease setting.
D000671:Amputation, Surgical; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006614:Hindlimb; D008175:Lung Neoplasms / Q000556:secondary*; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000556:secondary; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000556:secondary* / Q000601:surgery
D008748:Methylcholanthrene