Enrichment of specific suppressor T cells and characterization of their surface markers.
A simple method is described which allows antigen-specific suppressor T cells to be enriched by greater than 100-fold. The enriched cells have the following characteristic markers: Ig-, Thy-1+, Ly-1-, Ly-2,3+, and I-J+. More than 30% of this population could be killed directly by an antiserum specific for the I-J subregion gene product in the presence of complement.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D002469:Cell Separation; D006649:Histocompatibility Antigens; D007108:Immune Tolerance; D007141:Immunoglobulin Fc Fragments; D007165:Immunosuppression Therapy; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens; D007141:Immunoglobulin Fc Fragments