Regulation of CFU-S proliferation by locally produced endogenous factors.
The presence of proliferating and non-proliferating CFU-S in, respectively, the bone marrow and spleens of phenylhydrazine (PHZ) treated mice has afforded the opportunity to investigate the presence and role of local factors responsible for the control of CFU-S proliferation. When bone marrow cells from PHZ treated mice are incubated with irradiated spleen cells taken from the same mice, there is a marked fall in the proportion of femoral CFU-S in DNA synthesis. In the converse experiments rapid triggering of splenic CFU-S is achieved. Changes in CFU-S proliferation have also been demonstrated in other situations where cell populations containing proliferating and minimally proliferating CFU-S are mixed.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002455:Cell Division; D003115:Colony-Stimulating Factors; D004247:DNA / Q000096:biosynthesis; D006023:Glycoproteins; D006412:Hematopoietic Stem Cells; D008297:Male; D051379:Mice; D010659:Phenylhydrazines; D013154:Spleen / Q000166:cytology / Q000528:radiation effects
D003115:Colony-Stimulating Factors; D006023:Glycoproteins; D010659:Phenylhydrazines; D004247:DNA