Toxic delirium after L-dopa medication.
L-DOPA-psychosis is a frequent side effect of the combined treatment of Parkinson's disease with L-DOPA and peripherally active decarboxylase inhibitors. Regional human post-mortem brain studies showed a significant increase of noradrenaline and serotonin particularly in extrastriatal areas, whereas the lenticular nuclei were not involved. The significance of extrastriatal neurotransmitter dysfunctions for psychiatric disorders is discussed.
D001344:Autopsy; D001921:Brain / Q000378:metabolism; D003693:Delirium / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin; D004295:Dihydroxyphenylalanine; D009638:Norepinephrine