Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets.
Spleen T cells have been stimulated with Concanavalin A (Con A) under conditions which lead to the production of non-specific factor (NSF), a substance which replaces T cells for B-cell responses to certain antigens. We have examined the ability of multiple aliquots of B cells to react to the NSF derived from single T cells, and have found great heterogeneity of response. We postulate that there exist subsets of T cells which vary in either the quantity or the quality of the non-specific factor(s) they can produce on stimulation, and that in turn there must also be matching subsets of B cells which may vary in their susceptibility to such factors.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D008213:Lymphocyte Activation; D008222:Lymphokines; D008433:Mathematics; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology*
D008222:Lymphokines