Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.
Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006241:Haptens; D007126:Immunoglobulin Allotypes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology*; D008811:Mice, Inbred DBA / Q000276:immunology; D010767:Phosphorylcholine / Q000276:immunology*; D012730:Sex Chromosomes; D013154:Spleen / Q000276:immunology
D002352:Carrier Proteins; D006241:Haptens; D007126:Immunoglobulin Allotypes; D010767:Phosphorylcholine; D002794:Choline