The role of vasopressin in blood pressure control and in experimental hypertension.
1. The role of vasopressin in blood pressure control and in the pathogenesis of one-kidney Goldblatt hypertension in the conscious dog was investigated. 2. Infusion of synthetic arginine vasopressin to elevate plasma levels approximately five-fold caused bradycardia in normal dogs and increase in mean arterial blood pressure in dogs with pharmacological autonomic blockade. 3. A similar degree of elevation of plasma vasopressin concentration was observed after mild non-hypotensive haemorrhage. 4. Renal artery constriction in unilaterally-nephrectomized dogs caused a rise in plasma renin activity and only a doubling of plasma vasopressin concentration, but a marked rise in mean arterial blood pressure. 5. Vasopressin may play a role in normal cardiovascular homeostatic responses, but its role in the pathogenesis of this form of hypertension is unlikely to be significant.
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects; D001794:Blood Pressure; D003681:Dehydration / Q000503:physiopathology; D004285:Dogs; D006470:Hemorrhage / Q000503:physiopathology; D006977:Hypertension, Renal / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000097:blood / Q000503:physiopathology*; D008297:Male; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins