Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.
Adult female (NZB/NZW)F1 hybrid mice with documented autoimmune glomerulonephritis resembling systemic lupus erythematosus were treated with fractionated total lymphoid irradiation (TLI), a modification of the radiotherapeutic regimen currently used for the treatment of Hodgkin disease. After TLI, proteinuria subsided in all mice that had undergone radiotherapy, and the mean survival increased from 359 days in untreated controls to 545 days. It is suggested that TLI should be further investigated as a new approach for immunoregulation of autoimmune disorders.
D000818:Animals; D001327:Autoimmune Diseases / Q000532:radiotherapy*; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology / Q000532:radiotherapy; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000532:radiotherapy; D008196:Lymph / Q000528:radiation effects*; D051379:Mice; D011507:Proteinuria