title: The evaluation of tiodonium chloride as an antiplaque and anticaries agent. I. Preliminary in vitro and in vivo studies.
abstract: Tiodonium chloride was evaluated for its efficacy against Streptococcus mutans. Depending upon the concentration used, it was found to have either bacteriocidal or bacteriostatic activity against S mutans and ti inhibit the accumulation of plaque formed in vitro by this organism. When applied as a mouthrinse in hamsters infected with S mutans, tiodonium chloride significantly reduced the accumulation of dental plaque. Chlorhexidine gluconate was tested as a positive control in the in vivo experiment.
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006224:Cricetinae; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D004341:Drug Evaluation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009861:Onium Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013295:Streptococcus mutans / Q000187:drug effects; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D009861:Onium Compounds; D013876:Thiophenes; C020944:tiodonium chloride