[Mechanism of the adjuvant action: effect on the stem cell and B-lymphocyte migration from the bone marrow].
The authors studied the influence of synthetic polyelectrolytes of polyacrylic acid and poly-2-methyl-5-vinylpyridine and of complete Freund's adjuvant on the migration of stem cells and B-lymphocytes from mouse bone marrow. The stem cell count was evaluated by the number of splenic colonies; as to B-cell migration--it was assessed by the accumulation of the antibody-forming cells forming from B-lymphocytes migrating in the spleen in the transfer of fixed number of T-lymphocytes. As revealed the synthetic substances under study intensified the migration of stem cells and of B-lymphocytes to a much greater extent than Freund's adjuvant. The mechanisms of the influence of the adjuvants used on cell migration processes are discussed.
D000180:Acrylic Resins / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology; D001402:B-Lymphocytes / Q000276:immunology*; D001854:Bone Marrow Cells; D002452:Cell Count; D002465:Cell Movement; D005620:Freund's Adjuvant / Q000494:pharmacology; D051379:Mice; D011145:Polyvinyls / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D013154:Spleen / Q000166:cytology
D000180:Acrylic Resins; D000276:Adjuvants, Immunologic; D011145:Polyvinyls; D011725:Pyridines; D005620:Freund's Adjuvant
K mekhanizmu deĭstviia ad'iuvantov: vliianie na migratsiiu stvolovykh kletok i B-limfotsitov iz kostnogo mozga.