Effects of 5-methoxy-N,N-dimethyltryptamine on behavior and raphe unit activity in freely moving cats.
5-methoxy-N,N-dimethyltryptamine (5-MeODMT) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. This ranged from a 15% decrease at 10 microgran/kg, i.m., to a virtual complete depression of activity at 250 microgram/kg. 5-MeODMT's effects on raphe units occurred with a very short latency (3-5 min) and its duration of action was dose-dependent and limited to an hour or less. The degree of depression of raphe unit activity was directly related to the frequency of occurrence of a number of hallucinogen-specific cat behaviors such as limb flick and abortive groom. There was also a close temporal correlation between the depression of raphe unit activity and the occurrence of these behaviors. These data indicate that the effects of 5-MeODMT may be primarily dependent on its actions upon brain serotonin neurons.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects*; D002415:Cats; D004594:Electrophysiology; D005260:Female; D004130:N,N-Dimethyltryptamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects*; D013997:Time Factors; D014363:Tryptamines / Q000494:pharmacology*
D014363:Tryptamines; D004130:N,N-Dimethyltryptamine