Modified antibody response in rabbits treated with diphenylhydantoin.
Rabbits immunized subcutaneously with a mixture of normal human serum, Freund's complete adjuvant and a soluble diphenylhydantoin preparation, produced antibodies that differed qualitatively and quantitatively from the controls, as revealed by immunoelectrophoresis and passive haemagglutination. Antibodies in human IgG were greatly increased, whereas antibodies to human albumin were not influenced, and antibodies to some alpha- and beta-globulins were reduced.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis; D000917:Antibody Formation / Q000187:drug effects*; D007074:Immunoglobulin G; D010672:Phenytoin / Q000494:pharmacology*; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D012709:Serum Albumin; D010672:Phenytoin