title: [Use and mechanism of action of digitalis glycosides as anti-arrhythmic drugs].
abstract: Digitalis glycosides are used in the supraventricular arrhythmias either to slow the ventricular response or to restore or maintain sinus rhythm. The direct cellular effects of digitalis are probably not involved in its antiarrhythmic action. The indirect effects of digitalis through parasympathetic stimulation and adrenergic inhibition explain the results obtained when treating arrhythmias. At toxic doses, adrenergic stimulation may contribute to the arrhythmias of digitalis toxicity.
mesh_terms: D000889:Anti-Arrhythmia Agents; D001281:Atrial Fibrillation / Q000188:drug therapy; D001282:Atrial Flutter / Q000188:drug therapy; D004071:Digitalis Glycosides / Q000494:pharmacology / Q000627:therapeutic use*; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D004071:Digitalis Glycosides
vernacular_title: Utilisation et mécanismes d'action des digitaliques comme anti-arythmiques.