New translocations in chronic granulocytic leukaemia: t(X;22)(p22;q11) and t(15;22)(q26;q11).
Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial cytogenetic normalization of the bone marrow during busulphan induced remission were additional remarkable features of this case. In case 2 a translocation t(15;22)(q26;q11) was found. In this case the disease was characterized by an increase of unusually small megakaryocytes, thrombocytosis, and an accelerated course.
D000328:Adult; D001856:Bone Marrow Examination; D002871:Chromosome Banding; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy; D014960:X Chromosome / Q000648:ultrastructure