Microsomal vinyl oxide synthetase: modification of its kinetic parameters by chemical carcinogens.
The kinetic parameters of liver microsomal vinyl oxide synthetase as well as their modifications under the influence of various pretreatments have been evaluated, using 1,1,2-trichlorethylene (TCE) as a substrate. The results were correlated with those obtained using aldrin oxide synthetase and benzpyrene hydroxylase as typical cytochrome P-450 dependent enzymatic activity. The treatments of animals with chemical carcinogens selectively increase the affinity of those enzymes for their substrates.
D000452:Aldrin / Q000378:metabolism; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D002273:Carcinogens / Q000494:pharmacology*; D004852:Epoxy Compounds; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D014241:Trichloroethylene; D014753:Vinyl Compounds
D002273:Carcinogens; D004852:Epoxy Compounds; D014753:Vinyl Compounds; D014241:Trichloroethylene; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D001579:Benzopyrene Hydroxylase; D000452:Aldrin