The cytologic manifestations of lymphomatoid granulomatosis in cerebrospinal fluid. A case report.
The cytologic manifestations of lymphomatoid granulomatosis in the cerebrospinal fluid observed in a 50 year old white male with midbrain and spinal cord involvement are presented. The cerebrospinal fluid, obtained by cisternal puncture, contained predominantly undifferentiated medium-sized cells, which were retrospectively interpreted as reticular cells, These cells were characterized by an atypical nucleus with one or more prominent nucleoli and clumped chromatin granules, abundant cytoplasm and frequent amoeboid protrusions of the cytoplasmic membrane. Small numbers of undifferentiated plasmacytoid cells, lymphocytes, neutrophils and erythrocytes were evident. A few mitoses were also observed. These cellular characteristics are correlated with histology of the parent lesion in the midbrain obtained at the postmortem examination.
D002555:Cerebrospinal Fluid / Q000166:cytology*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000473:pathology*; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D014657:Vasculitis / Q000473:pathology*