HLA-D-associated 'Ia-like' antigens on human macrophages.
Human macrophages procured by culture of adherent peripheral blood mononuclear cells were investigated for reactivity in complement-dependent cytotoxicity tests with antisera having specificity for HLA-D-associated 'Ia-like' B-cell antigens. The antisera were found to be cytotoxic for 30%-70% of the macrophages from donors whose B cells were also reactive, and absorption with B cells also removed macrophage cytotoxicity. A B-cell xenoantiserum was also cytotoxic to macrophages. It is concluded that the HLA-D-associated 'Ia-like' antigens present on B cells are also expressed by macrophages, at least on a subpopulation.
D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003168:Complement Fixation Tests; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007106:Immune Sera; D008264:Macrophages / Q000276:immunology*
D006680:HLA Antigens; D007106:Immune Sera