H-2 gene complementation in cytotoxic T cell responses of female against male cells.
H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level of antigen-presenting cells (stimulators, targets), the other must be expressed in the responding T cell population.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005796:Genes; D005816:Genetic Complementation Test; D006648:Histocompatibility; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*