The effect of propanidid on systemic vascular resistance in man.
We have studied the peripheral vascular effect in man of propanidid 6 mg/kg, administered as a bolus injection during cardiopulmonary by-pass with the aorta cross-clamped and at constant perfusion flow. Ten measurements in eight patients were performed. A decrease was found in systemic vascular resistance: from 150.7 +/- 16.3 to 99.5 +/- 10.1 kPa x s/1. No venous pooling occurred. It is concluded that, in man, propanidid causes a vasodilation which must contribute to the hypotension it causes.
D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002315:Cardiopulmonary Bypass; D006801:Humans; D007022:Hypotension / Q000209:etiology; D011410:Propanidid / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D011410:Propanidid