Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.
Using an in vitro system of cell migration from glass capillary tubes, the nonsteroidal, anti-inflammatory agents sodium salicylate, aspirin, ibuprofen, phenylbutazone, and indomethacin were shown to inhibit the migration of human peripheral leucocytes in a dose-related manner. This drug action was not confined to one species, as shown by the modification of rat peripheral leucocyte motility by sodium salicylate and aspirin. The relevance of the human findings to the clinical effectiveness of these agents is discussed.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects*; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010653:Phenylbutazone; D001241:Aspirin; D012980:Sodium Salicylate; D007052:Ibuprofen; D007213:Indomethacin