title: Template-directed reactions of aminonucleosides.
abstract: We have studied the reactions between adenosine 5'-phosphorimidazolide and 9-(2-amino-2-deoxyxylofuranosyl) adenine (I) or 3'-methylamino-3'-deoxy-adenosine (II), both with and without a poly (U) template. We find that both amino compounds react much more rapidly than does adenosine, in the absence of a template. The rate of reaction is greatly enhanced by a poly (U) template in the case of I, but the enhancement is slight in the case of II.
mesh_terms: D000241:Adenosine; D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D000606:Amino Sugars; D003839:Deoxyadenosines / Q000031:analogs & derivatives*; D007093:Imidazoles; D011072:Poly U; D013698:Templates, Genetic
chemical_list: D000606:Amino Sugars; D003839:Deoxyadenosines; D007093:Imidazoles; D011072:Poly U; D000249:Adenosine Monophosphate; D000241:Adenosine