Cataleptic effect of 61-91 beta-lipotropic hormone in rat.
Intraventricular administration of a peptide from ovine pituitaries whose structure is identical to the 61-91 C-terminal portion of beta-lipotropic hormone (61-91 beta-LPH) induced catalepsy, muscular hypertonus and analgesia in rats. Naloxone inhibited both the analgesic and cataleptic effects. 1-dihydroxyphenylalanine (1-DOPA) completely prevented the cataleptic effect. The cataleptic effect of 61-91 beta-LPH was potentiated by 1-5-hydroxytryptophan (5-HTP).
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D002389:Catatonia / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D012756:Sheep; D014202:Tremor / Q000139:chemically induced; D008083:beta-Lipotropin / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D009270:Naloxone; D007980:Levodopa; D008083:beta-Lipotropin; D006916:5-Hydroxytryptophan