The gingival platinum line: a new finding following cis-dichlorodiammine platinum (II) treatment.
Cis-dichlorodiammine platinum (II) (DDP) is the salt of a heavy metal with a wide spectrum of antineoplastic activity. Its toxicity is multisystem and similar to that of other heavy metals, including lead and thallium. A young man being treated with primary adjuvant Adriamycin and DDP for osteogenic sarcoma is described who developed a gingival line which temporally was related to DDP administration. Although not chemically or histologically analyzed, we believe this to be a new finding related to DDP which corresponds to the lead line of plumbism and other heavy metal intoxication.
D000293:Adolescent; D002945:Cisplatin / Q000009:adverse effects*; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008297:Male; D009918:Orbital Neoplasms / Q000188:drug therapy; D012516:Osteosarcoma / Q000188:drug therapy
D002945:Cisplatin