Alpha-I-antitrypsin (Pi) phenotypes in Lyon, France: departure from Hardy-Weinberg equilibrium.
The validity of the Hardy-Weinberg equilibrium for Pi phenotypes was tested in a population of 1,653 randomly selected, healthy blood donors in Lyon, France. A significant departure from the equilibrium was found, with an excess of FF and SS homozygotes and a deficiency of FM heterozygotes.
D000293:Adolescent; D000328:Adult; D005602:France; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D000515:alpha 1-Antitrypsin
D000515:alpha 1-Antitrypsin