title: The intracranial injection of drug in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity.
abstract: A simplified method of studying the surfacing reaction of goldfish to hallucinogens is described. Goldfish weighing up to three grams are injected intracranially. Employing this method, d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butano-lamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were found to be as pharmacologically active as previously noted in fish and in man. The relationship of these drugs to their anti-serotonin activity is of particular interest to the allergist because of the way in which the congeners and derivatives of LSD block the action of serotonin on smooth muscle.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain; D005399:Fishes; D006213:Hallucinogens / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects*; D004130:N,N-Dimethyltryptamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D006213:Hallucinogens; D008238:Lysergic Acid Diethylamide; D004130:N,N-Dimethyltryptamine