Affinity chromatographic analysis of murine interferons induced by viruses and by T and B cell stimulants.
Murine interferons induced by viruses and by non-viral substances such as lectins, tilorone, lipopolysaccharide and Brucella have been analysed by affinity chromatography on a column of Sepharose coupled to antiviral interferon antibodies. The results reported here suggest that virus and B-cell stimulants induced interferons which are antigenically related and that T cell-dependent mitogens induce and "interferon like" molecule which appears to be antigenically and physiocochemically different.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002002:Brucella; D002846:Chromatography, Affinity; D007372:Interferons / Q000032:analysis*; D037102:Lectins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009522:Newcastle disease virus; D013601:T-Lymphocytes / Q000276:immunology*; D013994:Tilorone / Q000494:pharmacology; D014902:West Nile virus
D037102:Lectins; D008070:Lipopolysaccharides; D007372:Interferons; D013994:Tilorone