Terminal deoxyribonucleotidyl transferase activity in B-cell acute lymphocytic leukemia.
Moderately high levels of activity of the enzyme terminal deoxyribonucleotidyl transferase (TdT) were found in the leukemic cells of a patient with acute lymphyocytic leukemia. The proliferating cells were B lymphocytes bearing IgG antibody, and the disease was associated with an IgG monoclonal spike and a mediastinal mass. The observations in this case suggest that TdT is related more to the immaturity and proliferation of certain lymphoid stem cells than to their progress toward B- or T-cell differentiation.
D000293:Adolescent; D001402:B-Lymphocytes / Q000201:enzymology; D004259:DNA-Directed DNA Polymerase / Q000097:blood; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology*; D008297:Male; D009713:Nucleotidyltransferases / Q000097:blood*; D011947:Receptors, Antigen, B-Cell; D012075:Remission, Spontaneous; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000201:enzymology
D011947:Receptors, Antigen, B-Cell; D009713:Nucleotidyltransferases; D004259:DNA-Directed DNA Polymerase