Humoral factor that specifically regulates prothrombin (factor II) levels (coagulopoietin-II).
Prothrombin (Factor II) was decreased in rabbits by injection of a goat antiserum to prothrombin. When plasma from these rabbits was injected into normal animals, circulating prothrombin increased in the recipients, suggesting transfer of a humoral regulating factor ("coagulopoietin-II"). This coagulopoietin-II resisted boiling for 20 min. On Sephadex G-50 gel filtration, it remained in the retained volume, suggesting a molecular weight of less than 30,000. In an in vitro liver system, prothrombin increased in the incubation medium in the presence of coagulopoietin-II.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001779:Blood Coagulation Factors / Q000502:physiology*; D011516:Prothrombin / Q000276:immunology / Q000378:metabolism*; D011817:Rabbits
D001779:Blood Coagulation Factors; C018875:coagulopoietin-II; D011516:Prothrombin