title: The use of mixtures of octapressin and adrenaline in local anaesthetic solutions to obtain more effective vasoconstriction.
abstract: The synergistic effects of felypressin with adrenaline have been studied using the isolated central artery of the rabbit ear as a vascular model. Sub-constrictor doses of felypressin were shown to increase adrenaline's vasoconstrictor effect on this vessel. It is therefore suggested that a mixture of felypressin and adrenaline be used in local anaesthetic solutions in order to provide more effective vasoconstriction.
mesh_terms: D000779:Anesthetics, Local; D000818:Animals; D004338:Drug Combinations; D004357:Drug Synergism; D004431:Ear, External / Q000098:blood supply*; D004837:Epinephrine / Q000494:pharmacology*; D005259:Felypressin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008012:Lidocaine; D008236:Lypressin / Q000494:pharmacology*; D011318:Prilocaine; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D011318:Prilocaine; D008236:Lypressin; D005259:Felypressin; D008012:Lidocaine; D004837:Epinephrine