Local reaction to gingival injections of MER/BCG in guinea pigs.
The local reaction to gingival injections of methanol extraction residue of BCG (MER/BCG) was investigated in guinea pigs to help determine the potential of this agent in treating oral carcinoma. The drug was used in a standard and diluted form. Both concentrations were well tolerated and caused no ulceration or necrosis. Histological examinations performed at predetermined intervals showed an inflammatory response to the standard and the diluted solution. This reaction was more pronounced when the higher concentration was used. No changes in the alveolar bone were found in either of the groups. Complete healing with scar formation was evident four to six weeks later. The absence of severe reactions after injections of MER should encourage further investigations of this agent in the local treatment of neoplastic processes in the oral cavity.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage / Q000494:pharmacology*; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006168:Guinea Pigs; D006644:Histiocytes / Q000473:pathology; D007267:Injections; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D000432:Methanol / Q000008:administration & dosage / Q000494:pharmacology*; D009062:Mouth Neoplasms / Q000188:drug therapy; D009336:Necrosis / Q000473:pathology; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014456:Ulcer / Q000473:pathology
D001500:BCG Vaccine; D000432:Methanol