[IgE and cellular immunity in cutaneous lymphomas (author's transl)].
Serum IgE levels were measured (radioactive radial diffusion or radioimmuno assay) in 21 patients (14 mycosis fungoides or premycosis fungoides and 7 other lymphomas) and 1,019 controls. Elevated IgE levels (greater than or equal to 500 UI/ml) were found in 57 p. 100 of patients and 8,1 p. 100 of controls. The most important increase was noted in mycosis fungoides. Moreover, some of these patients showed a cellular immunity impairment: negative delayed skin tests, low percentage of T-lymphocytes forming E rosettes (2 out of 4 patients), decreased mitogenic response to Con A and P.H.A. In one patient with Sézary syndrome there was a dissociation between E and E active rosettes (low values) and anti H.T.L.A. serum (high values). This result could indicate that the Sézary cell is a poorly differentiated T-lymphocyte.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000032:analysis; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000276:immunology; D011230:Precancerous Conditions / Q000276:immunology; D012397:Rosette Formation; D012878:Skin Neoplasms / Q000276:immunology*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology
D007073:Immunoglobulin E
IgE et immunité cellulaire dans les hématodermies.