Prolonged interovulatory interval after oestradiol treatment in mares.
This study was designed to test if oestradiol treatment would prevent or delay luteolysis in mares. Mares (5/group) received 0, 0.1, 1.0 or 10.0 mg oestradiol-17 beta daily from the day of ovulation until the next ovulation or for a maximum of 32 days. This treatment did not prevent luteolysis which occurred 15.8, 16.8, 15.8 and 17.3 days after the previous ovulation for the mares treated with 0, 0.1, 1.0 and 10.0 mg oestradiol respectively. Although oestradiol treatment failed to alter oestrous behaviour after luteolysis, daily treatment with 10.0 mg oestradiol prevented follicular growth and inhibited ovulation.
D000818:Animals; D004031:Diestrus / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000502:physiology*; D006080:Ovarian Follicle / Q000254:growth & development; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy
D004958:Estradiol