A new in vivo assay of human lymphocyte-mediated immunity to melanoma.
Lymphocytes from melanoma patients more frequently inhibited the growth of human melanoma cells in the hamster cheek pouch than did lymphocytes from normal donors. Growth inhibition was accomplished with a much lower ratio of target cells to lymphocytes than in in vitro assays. The hamster cheek pouch assay can be used to study the relationship of blocking factors and humoral antibodies to cell-mediated immunity against human cancers.
D000818:Animals; D002277:Carcinoma / Q000276:immunology; D006224:Cricetinae; D006128:Growth; D006801:Humans; D007111:Immunity, Cellular; D007118:Immunoassay / Q000379:methods; D008297:Male; D008545:Melanoma / Q000276:immunology*; D008875:Middle Aged; D009368:Neoplasm Transplantation; D012509:Sarcoma / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014183:Transplantation, Heterologous