Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.
Bovine adrenal chromaffin granules have been shown to contain, in addition to Met-enkephalin and Leu-enkephalin, at least three small peptides with opiate receptor activity. One of these adrenal peptides has been purified to homogeneity and its sequence was shown to be Met-enkephalin-[Arg6,Phe&]. This heptapeptide was also found in beef striatal extracts in amounts comparable to those of Leu-enkephalin.
D000313:Adrenal Medulla / Q000032:analysis*; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002837:Chromaffin Granules / Q000032:analysis; D002845:Chromatography; D003342:Corpus Striatum / Q000032:analysis*; D004723:Endorphins / Q000302:isolation & purification*; D004745:Enkephalins / Q000302:isolation & purification*; D008970:Molecular Weight; D011869:Radioligand Assay
D004723:Endorphins; D004745:Enkephalins