title: Selective deficiency of IgG and IgA as a first stage defect in B cell differentiation.
abstract: A case of selective deficiency of IgG and IgA, in a 13-year old girl, is described. Immunologic investigations, showing an almost complete absence of IgG- and IgA-bearing lymphocytes and significant amounts of IgD and IgM positive cells, suggest the possibility of a block in the shift from IgM to IgG synthesis at the B lymphocyte level.
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes; D002454:Cell Differentiation; D004406:Dysgammaglobulinemia / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G