Previously unexplained HLA antigens of combined immunodeficiency disease due to Ia alloantigens.
The presence of extra reactions in the HLA typing of a combined immunodeficiency patient may be attributed to B-cell alloantibodies in the HLA typing sera. The presence of these reactions can be used to identify HLA sera containing B-cell antibodies for further B-cell studies. The alloantibodies in this study have some association with the HLA-D determinants and segregate with HLA in normal families.
D001402:B-Lymphocytes / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D007518:Isoantibodies / Q000302:isolation & purification*; D007519:Isoantigens; D010641:Phenotype
D006680:HLA Antigens; D007518:Isoantibodies; D007519:Isoantigens