title: Peroral chromones. A new way to treat allergic rhinitis?
abstract: Disodium chromoglycate (DSCG) is well documented in the topical treatment of allergic rhinitis. Its use does not lead to any major side effects. FPL 57579 is a new chromone compound which is well absorbed after oral administration. In a clinical trial, patients with allergic rhinitis underwent a nasal challenge before and after ingestion of FPL 57579. the effect on nasal airway resistance (NAR) was determined by rhinomanometry. In all cases there was a smaller increase in NAR after the intake of FPL 57579.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D002867:Chromones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D008365:Manometry; D009296:Nasal Cavity / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
chemical_list: D002867:Chromones