title: A separation of clinical from epidermal thinning effect in the topical glucocorticoid clobetasone butyrate.
abstract: Clobetasone butyrate ointment has been shown to be more effective in treating psoriasis and eczema than flurandrenolone ointment yet to cause less epidermal thinning in a human experimental model. This is an indication that the clinical activity of topical glucocorticoids may not necessarily be inseparable from their propensity to cause atrophy of the skin.
mesh_terms: D001623:Betamethasone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002452:Cell Count; D002986:Clinical Trials as Topic; D002990:Clobetasol / Q000031:analogs & derivatives; D004485:Eczema / Q000188:drug therapy; D005478:Flurandrenolone / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy; D012867:Skin / Q000166:cytology / Q000187:drug effects*
chemical_list: D005478:Flurandrenolone; C010893:clobetasone butyrate; D001623:Betamethasone; D002990:Clobetasol