Haemopoietic recovery in spleen and marrow after transplantation of bone marrow from either normal or hydroxyurea treated mice.
Haemopoietic regeneration was studied following x-irradiation and transplantation of bone marrow from either normal or hydroxyurea-treated donor mice, to ascertain the contribution of proliferating progenitor cells to regeneration. With transplantation of equivalent numbers of CFU-S, total DNA and 3HTdR uptake into DNA in spleen and femoral bone marrow and the erythroid, granulocytic and mononuclear cell populations were not significantly different between normal (NBM) and hydroxyurea-treated (HUBM) marrow. The response of hypertransfused x-irradiated mice to erythropoietin (EPO) administration was also not significantly different in spleens of mice receiving normal or hydroxyurea-treated marrow.
D000818:Animals; D001803:Blood Transfusion; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D016026:Bone Marrow Transplantation; D004247:DNA / Q000032:analysis; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006918:Hydroxyurea / Q000494:pharmacology*; D051379:Mice; D012038:Regeneration; D013154:Spleen / Q000187:drug effects / Q000502:physiology*
D004921:Erythropoietin; D004247:DNA; D006918:Hydroxyurea