title: High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma.
abstract: Five dogs with ostoegenic sarcoma were treated by surgical removal of the primary tumor and by adjuvant chemotherapy. Methotrexate at dosages of 3 to 6 g/m2 was used with leucovorin rescue. All dogs tolerated E g of methotrexate/m2 of body surface, but granulocytopenia precluded escalation beyond this dosage in 4 dogs. The rate and time of appearance of pulmonary metastases were not altered by treatment, with all dogs developing metastases at a median time of 4 months after amputation.
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D002955:Leucovorin / Q000008:administration & dosage*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*
chemical_list: D002955:Leucovorin; D008727:Methotrexate