Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.
Low serum IgA levels were found in patients taking phenytoin, together with evidence of depressed T cell function. There was no correlation between the dose or the serum level. A correlation was found, however, with HL-A status, patients with a low IgA showing increased frequency of HL-A2. It is suggested that epileptic patients with HL-A2 status are likely to develop IgA deficiency when given phenytoin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000096:biosynthesis; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005492:Folic Acid / Q000097:blood; D006680:HLA Antigens; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology
D001798:Blood Proteins; D006680:HLA Antigens; D037102:Lectins; D010672:Phenytoin; D005492:Folic Acid