Development of of macrophage migration inhibition in rabbits infected with virulent Treponema pallidum.
Peritoneal exudate cells from rabbits infected with Treponema pallidum Nichols were used as indicators of macrophage migration inhibitory factor activity. Between 3 and 15 weeks after infection, the migration of peritoneal exudate cells was inhibited in the presence of 3 to 25 microgram of T. phagedenis biovar Reiter protein per ml. Before this period, the migration patterns of peritoneal exudate cells from infected animals were uninhibited and similar to those from noninfected control rabbits. These observations were correlated with the development of active cell-mediated immunity during experimental T. pallidum infection.
D000818:Animals; D000942:Antigens, Bacterial; D002464:Cell Migration Inhibition; D004306:Dose-Response Relationship, Immunologic; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D008264:Macrophages / Q000382:microbiology*; D008297:Male; D011817:Rabbits; D013587:Syphilis / Q000382:microbiology; D014210:Treponema pallidum / Q000276:immunology / Q000472:pathogenicity*
D000942:Antigens, Bacterial; D008263:Macrophage Migration-Inhibitory Factors