Diagnosis of invasive candidosis by enzyme immunoassay of serum antigen.
Enzyme immunoassay was used to measure Candida albicans-related antigen in sera of rabbits and mice infected with C albicans. A range of heterologous antigens tested gave no cross reactions. Of the three patients who were investigated and gave positive reactions, two were confirmed as having deep candida infections. Enzyme immunoassay is efficient, simple, and sensitive, and may prove valuable in the early diagnosis of invasive candida infections.
D000328:Adult; D000818:Animals; D000946:Antigens, Fungal / Q000032:analysis; D002177:Candidiasis / Q000175:diagnosis* / Q000276:immunology; D003378:Counterimmunoelectrophoresis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008875:Middle Aged; D011817:Rabbits
D000946:Antigens, Fungal