Pressure lowering effect of timolol with reference to its topical vascular action.
The hemodynamic effect of timolol maleate in open angle glaucoma was studied rheo-oculographically. Increase in the ocular pulse which reaches maximal amplification 2 h after the instillation of the drug was observed. The maximal pressure lowering effect appeared 3 h after instillation, as if the hemodynamic effect were the trigger for the pressure lowering effect.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D005901:Glaucoma / Q000188:drug therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006956:Hyperopia / Q000188:drug therapy; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D013997:Time Factors; D013999:Timolol / Q000627:therapeutic use*
D011412:Propanolamines; D013999:Timolol