Preferential transmission of the Z deficient allele of alpha 1-antitrypsin.
The transmission of the Z deficient allele of alpha 1-antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.
D000483:Alleles; D002648:Child; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012737:Sex Factors; D000515:alpha 1-Antitrypsin / Q000235:genetics; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin