Enhancement of insulin-induced prolactin secretion by fluoxetine in man.
Fluoxetine hydrochloride, a specific inhibitor of serotonin reuptake, was given orally to five adult males to study its effect on fasting and insulin-stimulated release of PRL. A 3-day course of fluoxetine (30 mg daily) had no demonstrable effect on fasting PRL levels. Fluoxetine significantly enhanced insulin-induced PRL release. These data suggest that serotoninergic pathways have little or no part in the control of spontaneous PRL secretion in man, whereas they may play a role in insulin-stimulated PRL release.
D000328:Adult; D004357:Drug Synergism; D005215:Fasting; D005473:Fluoxetine / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011437:Propylamines / Q000494:pharmacology*
D007328:Insulin; D011437:Propylamines; D005473:Fluoxetine; D011388:Prolactin