Demonstration of a tryptaminergic mechanism in the rat beta-cell.
Yellow 5-HT fluorescence has been histochemically demonstrated in rat pancreatic islet cells in animals injected with L-5-HTP with or without pretreatment with the monoaminoxidase inhibitor nialamide. This fluorescence was not observed after inhibition of the aromatic amino acid decarobxylase. The results strongly suggest the presence of a tryptaminergic mechanism in the rat islet cells.
D001545:Benserazide / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008856:Microscopy, Fluorescence / Q000379:methods; D009526:Nialamide / Q000494:pharmacology; D014363:Tryptamines / Q000378:metabolism*
D014363:Tryptamines; D001545:Benserazide; D009526:Nialamide