title: Treatment of alopecia areata with dinitrochlorobenzene.
abstract: Persistent refractory alopecia areata in 26 patients was treated topically with dinitrochlorobenzene (DNCB). Sixteen patients have had excellent regrowth of hair; three patients could either not be initially sensitized or an adequate allergic contact dermatitis on the scalp did not develop. Two patients discontinued therapy within two months; hair growth did not develop in five patients despite an adequate trial. Augmentation of the T-lymphocyte pool via DNCB sensitization and challenge may become effective therapy for some patients with severe alopecia areata.
mesh_terms: D000287:Administration, Topical; D000506:Alopecia Areata / Q000188:drug therapy* / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009578:Nitrobenzenes / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes