On the interaction between the anti-inflammatory substance proquazone (RU 43-715) and phenprocoumone.
In a double blind study on 20 anticoagulated patients, the influence of the anti-inflammatory drug 1-isopropyl-4-phenyl-7-methyl-2 (1H) quinazolone on the degree of hypocoagulability was examined. In comparison to a placebo group, there was no statistical difference in the Quick precentage, in coagulation factors II, VII, and X, and in platelet aggregation induced by collagen and by epinephrine respectively. In addition, no increased bleeding tendency could be observed during the study.
D015110:4-Hydroxycoumarins / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004347:Drug Interactions; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000627:therapeutic use*; D010919:Placebos; D010974:Platelet Aggregation / Q000187:drug effects; D011516:Prothrombin / Q000378:metabolism; D011799:Quinazolines / Q000009:adverse effects / Q000494:pharmacology*
D015110:4-Hydroxycoumarins; D000893:Anti-Inflammatory Agents; D010919:Placebos; D011799:Quinazolines; C011385:proquazone; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X; D010644:Phenprocoumon