Preservation of canine hearts after warm ischemia (zero to thirty minutes) and one to two days of hypothermic storage. A comparative analysis of crystalloid and colloid solutions with different osmolarity and ion composition.
The effect of extracellular crystalloid (Ringer's) and colloid (silica gel fraction [SGF]) solutions, and intracellular crystalloid (Sacks) and colloid (modified silica gel fraction [MSGF]) solutions for canine heart preservation in a 24 to 48 hour model of hypothermic storage and zero to 30 minutes of warm ischemia was compared. Canine hearts flushed with an intracellular colloid solution (MSGF) had better survival rates after transplantation than did the hearts flushed with intracellular crystalloid solutions (Sacks). Better survival results also were observed in the group of hearts flushed with extracellular colloid (SGF) solutions than extracellular crystalloid (Ringer's) solutions. The most important theoretical factor in heart preservation appears to be hyperosmolarity and elevated concentration of potassium, proteins, and glucose.
D000818:Animals; D003080:Cold Temperature; D003102:Colloids / Q000494:pharmacology; D003327:Coronary Disease / Q000503:physiopathology; D003460:Crystallization; D004285:Dogs; D005260:Female; D006321:Heart / Q000502:physiology*; D016027:Heart Transplantation; D006358:Hot Temperature; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure; D009994:Osmolar Concentration; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D011309:Preservation, Biological; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D013997:Time Factors; D014184:Transplantation, Homologous
D003102:Colloids; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical