Skin reactivity to Candida and streptokinase-streptodornase antigens in normal pediatric subjects: influence of age and acute illness.
Tests for delayed cutaneous hypersensitivity were carried out with Candida and streptokinase-streptodornase antigens in 245 normal pediatric subjects, ranging in age from 17 days to 5 10/12 years. The group comprised patients with a variety of acute illnesses and a series of control subjects. There was a progressive increase in the frequency of cutaneous responses with age. About one-third of infants under one year and four-fifths of one to five-year-old children had positive induration reactions to at least one antigen. Candida was the more reactive antigen in the first year of life; thereafter there was comparable responsiveness to both antigens. Our results showed no difference in percent reactivity between acutely ill and control subjects.
D000208:Acute Disease; D000367:Age Factors; D000941:Antigens / Q000032:analysis*; D001424:Bacterial Infections / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005759:Gastroenteritis / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007223:Infant; D007231:Infant, Newborn; D012140:Respiratory Tract Diseases / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D012882:Skin Tests; D013299:Streptodornase and Streptokinase / Q000276:immunology*
D000941:Antigens; D013299:Streptodornase and Streptokinase