The triplet-state charge-transfer reaction between p-nitroacetophenone and guanosine monophosphate: a possible mechanism for electron-affinic radiosensitization.
Using flash photolysis it has been observed that the triplet state of p-nitroacetophenone reacts rapidly with guanosine monophosphate to give the p-nitroacetophenone radical anion, and presumably the guanine radical cation is also formed in this reaction. From this observation, it is predicted by theory that a similar reaction will occur between p-nitroacetophenone and the triplet state of guanosine monophosphate. Because guanine is excited to its triplet state when DNA is irradiated with X-rays, it is suggested that the charge transfer reaction between p-nitroacetophenone and the triplet state of guanine contributes to the radiosensitizing action of p-nitroacetophenone.
D000098:Acetophenones / Q000494:pharmacology; D004247:DNA / Q000528:radiation effects*; D004583:Electrons; D005609:Free Radicals; D006147:Guanine / Q000378:metabolism; D006150:Guanine Nucleotides / Q000378:metabolism; D010083:Oxidants, Photochemical; D010084:Oxidation-Reduction; D010782:Photolysis; D011838:Radiation-Sensitizing Agents; D014965:X-Rays
D000098:Acetophenones; D005609:Free Radicals; D006150:Guanine Nucleotides; D010083:Oxidants, Photochemical; D011838:Radiation-Sensitizing Agents; D006147:Guanine; D004247:DNA