The effect of Escherichia coli endotoxin on lysosomal enzymes in the domestic fowl.
During the 2 h following the injection of chickens (aged nine to 11 weeks) with endotoxin isolated from a pathogenic strain of Escherichia coli (O78) there was a transient rise in the activity of acid phosphatase, aryl sulphatase and beta-glucuronidase in the plasma, suggesting increased release of these enzymes from lysosomes. This was followed by a fall in their activity which may have been due largely to stabilisation of the lysosomal membrane brought about by increased secretion of adrenocortical hormones and/or accelerated removal of the enzymes from circulation by the reticuloendothelial system.
D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D001192:Arylsulfatases / Q000097:blood; D002645:Chickens / Q000097:blood*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005966:Glucuronidase / Q000097:blood; D008247:Lysosomes / Q000201:enzymology*
D004731:Endotoxins; D000135:Acid Phosphatase; D001192:Arylsulfatases; D005966:Glucuronidase