[T- and B-lymphocyte determination in infectious mononucleosis].
In 12 children with infectious mononucleosis the peripheral blood T- and B-lymphocytes were studied and compared to a control group of 26 children, aged 2 to 13 years, without any infection. Spontaneous sheep red blood cell rosettes were used as a T-cell marker, demonstration of surface immunoglobulins by immunofluorescence technique was used as a B-cell marker. Patients with infectious mononucleosis showed a marked increase of T-lymphocytes (percentage and absolute numbers) in comparison with the control group; the difference was statistically significant. Since only B-lymphocytes are the target cells fo Epstein-Barr virus, the increase of T-lymphocytes in infectious mononucleosis probably represents the response of cell mediated immunity against B-lymphocytes which are altered in their antigenic properties by Epstein-Barr virus.
D000293:Adolescent; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D007244:Infectious Mononucleosis / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
T- und B-Lymphozyten-Bestimmung bei Mononucleosis infectiosa.