[Allogenic bone marrow transplantation in severe aplastic anemia and refractory acute leukemia. 35 cases].
23 patients with severe aplastic anemia have been treated. 10 marrow grafts between HLA matched siblings were performed after conditioning with cyclophosphamide. 5 are still alive at over 7 months to over 2 1/2 years after grafting. 3 are hemopoietic chimeras and 2 show autologous marrow reconstitution. 13 patients were treated by ALG with or without transfusion of allogeneic marrow. 9 are still alive with partial to complete autologous hemopoietic reconstitution at over 1 month to over 4 years. It is concluded that in many instances aplastic anemia is an autoimmune disease rather than a primary failure of the hemopoietic stem cells. In acute leukemia allogeneic marrow grafts still pose enormous problems and only one of our 12 grafts has become a longterm survivor.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000628:therapy*; D001327:Autoimmune Diseases / Q000276:immunology; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D007938:Leukemia / Q000628:therapy; D009030:Mosaicism; D014184:Transplantation, Homologous
D003520:Cyclophosphamide
Allogene Knochenmarktransplantation bei schwerer aplastischer Anämie und refraktärer akuter Leukämie.