Specificity of lactoferrin as an inhibitor of granulocyte-macrophage colony-stimulating activity production from fetal mouse liver cells.
Fetal mouse liver cultures capable of producing both erythropoietin (Ep) and granulocyte-macrophage colony stimulating activity (GM-CSA) were used to study the specificity of lactoferrin as an inhibitor of the production of GM-CSA. Both a granulocyte-derived colony-inhibiting activity (CIA) and lactoferrin inhibited GM-CSA production while having no effect on Ep production. These results demonstrate the specificity of lactoferrin for GM-CSA production.
D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D005333:Fetus; D006098:Granulocytes / Q000378:metabolism*; D007781:Lactoferrin / Q000494:pharmacology*; D007782:Lactoglobulins / Q000494:pharmacology*; D007951:Leukemia, Myeloid / Q000097:blood; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009504:Neutrophils / Q000378:metabolism; D014168:Transferrin / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D007782:Lactoglobulins; D014168:Transferrin; D004921:Erythropoietin; D007781:Lactoferrin