title: "Keratolytic" effect of salicylic acid.
abstract: The "keratolytic" effect of salicylic acid was examined in guinea-pig skin. Using a fluorescent staining method the str. corneum cells could be seen to rapidly become detached. The cellular walls remained unchanged. This drug therefore appears to primarily reduce the intercellular cohesiveness of the horny cells.
mesh_terms: D000818:Animals; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D012459:Salicylates / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*
chemical_list: D012459:Salicylates