Histocompatibility matching in poor prognosis combined procedure keratoplasty.
To determine the effect of histocompatibility matching and mismatching at the rabbit leukocyte-locus A (RL-A locus) on graft survival in rabbits, we created a model to enhance graft failure. Rabbit corneas received alkali burns with consequent vascularization of the graft bed. Each rabbit underwent large (10-mm) penetrating keratoplasty and simultaneous lens extraction. Grafts in four of six corneas from the matched group remained transparent for the extent of the experiment; none of the grafts in the mismatched group were transparent at the end of the experiment.
D000818:Animals; D002387:Cataract Extraction / Q000009:adverse effects; D003315:Cornea / Q000098:blood supply; D003316:Corneal Diseases / Q000150:complications; D016039:Corneal Transplantation; D004195:Disease Models, Animal; D006084:Graft Rejection; D006085:Graft Survival; D006650:Histocompatibility Testing; D006789:Host vs Graft Reaction; D011379:Prognosis; D011817:Rabbits; D014184:Transplantation, Homologous