T lymphocytes inhibiting factors in renal cancer: evaluation of differences between arterial and renal venous blood levels of E rosette forming cells.
The cellular immune response has been reported to be impaired in patients with renal cancer and to be increased by removal of the tumor bulk. T lymphocyte levels in the vein of the neoplastic kidney were investigated in 4 patients to assess the presence of a T lymphocyte inhibiting factor produced by the tumor. T lymphocyte levels resulted in significantly decreased tumorous venous blood, whether compared to arterial, contralateral or peripheral blood. A similar result was not found in 10 control patients. Some hypotheses on the nature of this T lymphocyte inhibition are discussed.
D006801:Humans; D007111:Immunity, Cellular; D007680:Kidney Neoplasms / Q000276:immunology*; D012077:Renal Artery; D012082:Renal Veins; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*