Fucose-binding Lotus tetragonolobus lectin binds to human polymorphonuclear leukocytes and induces a chemotactic response.
Fucose-binding L. tetragonolobus lectin to the surface of human polymorphonuclear leukocytes (PMN) and induces a chemotactic response. Both surface binding and chemotaxis are inhibited by free fucose but not by fructose, mannose, or galactose. The lectin-binding sites on PMN are unrelated to the A, B, or O blood group antigen. Utilization of this lectin should be a useful tool in isolating PMN membrane components and in analyzing the mechanism of neutrophil chemotaxis.
D000017:ABO Blood-Group System; D001665:Binding Sites; D002634:Chemotaxis, Leukocyte; D004306:Dose-Response Relationship, Immunologic; D005455:Fluorescent Antibody Technique; D005643:Fucose / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D009504:Neutrophils / Q000276:immunology*
D000017:ABO Blood-Group System; D037102:Lectins; D005643:Fucose