Effects of Poly A. Poly U in vivo alterations of proportions of T and B cell subsets.
Spleens and thymuses of mice were examined for changes in lymphocyte subpopulations after in vivo treatment with a double stranded synthetic polynucleotide: Poly A.Poly U. The cell populations were characterized on a biophysical basis: the electrical charge of cell surface assessed by the anodic electrophoretic mobility. The proportion of spleen cells exhibiting a high electrophoretic mobility (T lymphocytes) increased markedly on the 3rd day after a single intravenous injection of Poly A.Poly U. In thymuses, early important variations in electrophoretic distribution profiles were observed after Poly A.Poly U injection, suggesting that adjuvant acts on T cells.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D004586:Electrophoresis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011063:Poly A-U / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects*
D011063:Poly A-U