Effect of aluminum hydroxide on diflunisal absorption.
1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC-method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co-administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%.
D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001682:Biological Availability; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D012459:Salicylates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; D000536:Aluminum Hydroxide