title: Post-operative analgesia with diflunisal.
abstract: An open study was carried out in 196 consecutive patients who had undergone orthopaedic (103) or gynaecological (93) surgical procedures to assess the effectiveness and tolerability of a single dose of 500 mg diflunisal in the relief of postoperative pain. Diflunisal was given when patients first complained of pain, and pain severity before and at intervals up to 6 hours after the dose was assessed using a 10-point analogue scale. The results showed that diflunisal was both prompt and prolonged in its effect. No pain was reported after 1 hour in 138 (71%) of the 196 patients, and after 6 hours only 13 (7%) still reported some pain. Diflunisal was equally as effective in the two groups. Side-effects were reported in 13 (7%) patients but these were ones commonly found in the post-operative situation.
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D012459:Salicylates / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates