New techniques for interruption of gastroesophageal venous blood flow.
Enlarged gastroesophageal veins were successfully obliterated in 41 patients using embolization with modified autogenous clots and/or Gelfoam, balloon occlusion, iatrogenic perivenous hematoma, sclerosing agents (Sotradecol and Keflin), or a combination of these methods. Thirteen patients were actively bleeding when studied, and the site of bleeding was detected in 4. Surgical exploration of 16 patients and autopsy study of 5 showed persistent obliteration ranging between three weeks and seven months. No major complications requiring reparative surgery were encountered. Gelfoam soaked with Sotradecol is the preferred agent because it provides persistent obliteration of the embolized veins. Patients who are acutely bleeding or have done so previously are candidates for selective obliteration of the gastroesophageal veins.
D002404:Catheterization; D003331:Coronary Vessels; D004621:Embolization, Therapeutic; D004947:Esophagus / Q000098:blood supply*; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use; D006488:Hemostasis, Surgical; D006489:Hemostatic Techniques; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging / Q000628:therapy*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000628:therapy*; D011859:Radiography; D013270:Stomach / Q000098:blood supply*; D013917:Thrombin / Q000627:therapeutic use; D014680:Veins
D013917:Thrombin