Localization of H-2 antigens on mouse trophoblast cells.
The presence of H-2 antigens of the paternal and maternal haplotypes on mouse trophoblast cells was examined at several stages of pregnancy by using a sensitive immunolabeling technique followed by quantitative radioautography. Results revealed the presence of H-2 antigens (determined by the K or D loci) of both parental haplotypes on the F1 trophoblast cells. At 14-16 d of gestation, the antigen density was equivalent to that on adult thymocytes and there was a further 50% increase on day 18. H-2 antigens of both parental haplotypes are also found to be expressed on 11-13 d trophoblast cells.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D003433:Crosses, Genetic; D005865:Gestational Age; D006649:Histocompatibility Antigens / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology*
D000906:Antibodies; D006649:Histocompatibility Antigens