Studies on the influence of thiols on lymphocytes (T-type lymphocytes) functions.
We described changes in nonprotein sulfhydryl content and in intracellular concentration of cysteine (unbound form) in lymphocytes incubated with cysteine, cysteine hydrazide and D-penicillamine (dimethy lcysteine) in concentrations which do not alter the viability of the cells. Essential differences between the action of cysteine and cysteine hydrazide on one hand, and D-penicillamine on the other, can be observed. The formers cause the argumentation in nonprotein thiols content in lymphocytes, whereas D-penicillamine in a similar concentration does hardly alters the intracellular redox -SH/SS potential of nonprotein thiols within the lymphocytes.
D000818:Animals; D003545:Cysteine / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction; D010396:Penicillamine / Q000494:pharmacology; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology; D014529:Uridine / Q000378:metabolism
D013438:Sulfhydryl Compounds; D011732:Pyridoxal Phosphate; D010396:Penicillamine; D003545:Cysteine; D014529:Uridine