Measles virus meningoencephalitis. Immunofluorescence study of brains infected with virus mutants.
The localization of measles virus antigens in hamster brains inoculated with a temperature-sensitive mutant of measles virus r its revertant was studied by immunofluorescence. We found significantly less virus antigen in mutant-inoculated than in revertant-inoculated brains. In mutant-inoculated brains the virus antigens were very often found in the meninges. Possible mechanisms for the development of experimental hydrocephalus and meningoencephalitis are discussed.
D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D008459:Measles virus / Q000302:isolation & purification; D008578:Meninges / Q000382:microbiology; D008590:Meningoencephalitis / Q000150:complications / Q000382:microbiology*; D009154:Mutation; D010253:Respirovirus Infections / Q000150:complications / Q000382:microbiology*; D014779:Virus Replication
D000956:Antigens, Viral