title: PKU locus: genetic linkage with human amylase (Amy) loci and assignment to linkage group I.
abstract: The linked alpha-amylase loci Amy 1 and Amy 2 were evaluated for their linkage relationship to the PKU locus using data collected from two (one Czech and one Polish) groups of families. The five sibships informative for Amy 1:PKU give a z score of 1.505 at theta = 0.00 and the eight sibships informative for Amy 2:PKU give a z score of 2.709 at theta = 0.00. Due to the tandem position of Amy 1 and Amy 2 loci, these data could be combined, and linkage between Amy and PKU loci established with a z score 4,214 at theta = 0.00. The practical significance of the linkage, especially for identifying PKU allele carriers, is emphasized.
mesh_terms: D000681:Amylases / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005260:Female; D005796:Genes; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D010661:Phenylketonurias / Q000235:genetics*; D011110:Polymorphism, Genetic; D000516:alpha-Amylases / Q000235:genetics*
chemical_list: D000681:Amylases; D000516:alpha-Amylases