title: Effects o;f vitrectomy infusion solutions containing oxacillin, methicillin, or lincomycin.
abstract: Experiments conducted in rabbits showed no toxic effects on the retina by electroretinogram after vitrectomy when the infusion fluid contained as much as 50 microgram/ml of methicillin or lincomycin or 20 microgram/ml oxacillin. An abnormal electroretinogram was found in eyes receiving oxacillin in a concentration of 50 microgram/ml. Histologic studies showed ocular damage with concentrations of 50 microgram/ml of methicillin or lincomycin or 20 microgram/ml of oxacillin. All antibiotics were nontoxic to retina at 10 microgram/ml concentration, both by ERG and histology.
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D004596:Electroretinography; D009877:Endophthalmitis / Q000517:prevention & control*; D008034:Lincomycin / Q000009:adverse effects / Q000627:therapeutic use*; D008712:Methicillin / Q000009:adverse effects / Q000627:therapeutic use*; D010068:Oxacillin / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D014822:Vitreous Body / Q000601:surgery*
chemical_list: D008034:Lincomycin; D008712:Methicillin; D010068:Oxacillin