title: [Results of the study of preventive effectiveness and side effects of anti-influenza lactoglobulin in controlled epidemiologic trial].
abstract: Prophylactic activity and side action of antiinfluenza lactoglobulin were studied under conditions of controlled epidemiological trial in 6361 persons during the epidemiological rise of influenza incidence. The data obtained pointed to the absence of any protective effect of antiinfluenza lactoglobulin. Marked allergenic properties of lactoglobulin and development of sensitization in the persons under observation were found during the study of the side-effect of the preparation. Thus, the absence of prophylactic efficacy and the sensitizing action of antiinfluenza lactoglobulin pointed to the inexpediency of its use for prophylactic and therapeutic purpose.
mesh_terms: D002986:Clinical Trials as Topic; D004812:Epidemiologic Methods; D005069:Evaluation Studies as Topic; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D007782:Lactoglobulins / Q000009:adverse effects / Q000627:therapeutic use*; D009031:Moscow; D012713:Serum Sickness / Q000453:epidemiology / Q000209:etiology
chemical_list: D007252:Influenza Vaccines; D007782:Lactoglobulins
vernacular_title: Rezul'taty izucheniia profilakticheskoĭ effektivnosti i pobochnogo deĭstviia protivogrippoznogo laktoglobulina v kontroliruemom epidemiologicheskom opyte.