title: A bactericidal effect for human lactoferrin.
abstract: Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.
mesh_terms: D001059:Apoproteins / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D007501:Iron / Q000378:metabolism; D007781:Lactoferrin / Q000494:pharmacology*; D007782:Lactoglobulins / Q000494:pharmacology*; D013045:Species Specificity; D013291:Streptococcus / Q000187:drug effects*; D013295:Streptococcus mutans / Q000187:drug effects*; D014734:Vibrio cholerae / Q000187:drug effects*
chemical_list: D001059:Apoproteins; D002614:Chelating Agents; D007782:Lactoglobulins; D007501:Iron; D007781:Lactoferrin