Analysis of biological and immunological activities in the two pools of LH released during constant infusion of luteinizing hormone-releasing hormone (LHRH) in men.
In response to constant infusion of a submaximal dose of LHRH (0.2 microgram/min for 4 hours), luteinizing hormone (LH) was released in a biphasic pattern in 6 normal men. When the in vitro biologic activity of plasma LH was compared to the immunologic activity throughout the response to LHRH, the B/I ratio remained unchanged (3.6 +/- 0.5, mean +/- SE). Thus, in men the biologic activity of stored LH (acutely releasable) is not different from the presumably newly synthesized hormone that is released as the second pool during prolonged LHRH infusion.
D000328:Adult; D001681:Biological Assay; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007118:Immunoassay; D007263:Infusions, Parenteral; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone