Transient hypotensive effect of phenytoin in man.
Phenytoin or an identically appearing placebo was administered in a double-blind fashion to 20 patients with mild essential hypertension. A significant fall in supine systolic blood pressure was noted 30 minutes to 1 hour after the oral administration of 100 mg phenytoin. No significant antihypertensive effect was observed after the patients had received 100 mg phenytoin every 8 hours for two weeks. Phenytoin had no effect on the diastolic blood pressure. It is concluded that the previously described hypotensive effect of phenytoin is a transient phenomenon which is of no therapeutic benefit in the long-term management of patients with essential hypertension.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use*; D010919:Placebos
D010919:Placebos; D010672:Phenytoin