A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee.
A randomized, double-blind crossover study conducted on 55 patients showed tolmetin (Tolectin; Ethnor) (900 mg daily) to be as effective as aspirin (4 500 mg daily) in relieving the symptoms and signs of osteo-arthritis of the knee. Overall, aspirin produced significantly more side-effects, but the incidence of gastro-intestinal side-effects did not differ significantly. In almost every comparison tolmetin had the better score, but differences were not statistically significant; the only exception was the evaluation of the patients' well-being at mid-therapy, which significanlty favoured tolmetin.
D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007719:Knee Joint; D010003:Osteoarthritis / Q000188:drug therapy*; D011758:Pyrroles / Q000627:therapeutic use*; D014046:Tolmetin / Q000009:adverse effects / Q000627:therapeutic use*
D011758:Pyrroles; D014046:Tolmetin; D001241:Aspirin