title: [The effects of the pause at the end of inspiration on gas exchange and hemodynamics during artificial ventilation].
abstract: We have studied the effects of an inspiratory pause (PI) during artificial ventilation in 13 patients in acute respiratory insufficiency. The effects on gas exchange, haemodynamics and distribution of ventilation were observed. During the period of study the total volume, the inspiration/expiration ratio and the inspired oxygen concentration were all maintained constant. With the inspiratory pause arterial oxygenation has not changed significantly, whereas it did change favourably with PEEP. The physiological dead space (VD/VT) was reduced in proportion to the duration of the inspiratory pause. These results suggest that the inspiratory pause triggers regional modification of the ventilation/perfusion ratio, favouring a reduction of the VD/VT ratio. However, this improvement of the VD/VT ratio does not seem to influence the oxygenation or the total distribution of ventilation in this type of patient.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011175:Positive-Pressure Respiration; D012126:Respiratory Dead Space; D012131:Respiratory Insufficiency / Q000503:physiopathology*; D013997:Time Factors; D014692:Ventilation-Perfusion Ratio
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Effets de la pause en fin d'inspiration sur l'échange gazeux et l'hémodynamique chez des patients en ventilation mecanique.