Stimulating factors and cell recruitment in murine bone marrow stem cells and EMT6 tumours.
The role of a stimulating factor in cell recruitment and the kinetics of its secretion were investigated by in vivo and in vitro techniques. The association of these two methods made it possible to demonstrate that a non-cycling population liberates a factor which in turn stimulates quiescent bone marrow stem cells into DNA synthesis. Moreover, it seems that undamaged cells are capable of secreting this factor. A stimulating factor responsible for cell recruitment was also demonstrated in an experimental EMT6 tumour and the kinetics of its secretion reported.
D000818:Animals; D001854:Bone Marrow Cells; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000378:metabolism / Q000502:physiology*; D003561:Cytarabine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*
D003115:Colony-Stimulating Factors; D004273:DNA, Neoplasm; D003561:Cytarabine; D004247:DNA