Mitogenic activity of staphylococcal peptidoglycan.
Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observed in T cell-enriched and B cell-depleted mouse lymphocyte cultures. These data demonstrate that peptidoglycan-responding cells in mouse spleen cell cultures are B lymphocytes.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008934:Mitogens; D010457:Peptidoglycan / Q000276:immunology* / Q000633:toxicity; D013154:Spleen / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*
D008934:Mitogens; D010457:Peptidoglycan