Cell-mediated immunity to Nocardia asteroides induced by its ribonucleic acid protein fraction.
Guinea pigs immunized with ribonucleic acid protein fraction from Nocardia asteroides developed high cell-mediated immunity within 2 weeks, as shown by increased macrophage microbicidal activity and macrophage migration inhibition. This immunity protected against intravenous and subcutaneous challenge with N. asteroides and persisted for at least 70 days.
D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology*; D002464:Cell Migration Inhibition; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007114:Immunization; D007116:Immunization, Passive; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009617:Nocardia Infections / Q000517:prevention & control; D009616:Nocardia asteroides / Q000276:immunology*; D009698:Nucleoproteins / Q000276:immunology*; D012329:RNA, Bacterial / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology*; D012882:Skin Tests; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D001426:Bacterial Proteins; D009698:Nucleoproteins; D012329:RNA, Bacterial; D012261:Ribonucleoproteins