[Extrarenal effects of potassium-canrenoate. Haemodynamic investigations during neuroleptanalgesia in cardiosurgical patients (author's transl)].
Direct cardiac and vascular effects of the antikaliuretic diuretic potassium-canrenoate were measured in cardio-surgical patients during extracorporal circulation and immediatly after operations, each time in neuroleptanalgesia. During "steady state" extracorporeal circulation (aorta cross-clamped, constant flow rate of heart-lung-machine, constant hypothermia), in 13 patients no significant influence on peripheral circulation was found after i.v.-injection of 800 mg potassium-canrenoate. Neither arterial perfusion pressure (representing an arterial vascular reaction) nor changes in oxygenator-volume (indicating venous vasodilation or contraction) demonstrated significant differences in comparison to a control group. After cardiac surgery haemodynamic measurements were performed for a period of 60 minutes in 10 patients given 800 mg potassium-canrenoate. In comparison with a control group (n = 6), no significant differences in arterial pressure, heart rate, cardiac index and pulmonary arterial pressure were found. Left ventricular measurements, using a catheter tip manometer, revealed no direct positive inotropic effect of a single i.v.-injection of potassium-canrenoate. In acute myocardial failure during anaesthesia or in "low cardiac ouptut" following open heart surgery no improvement in myocardial contractility is obtained by i.v.-application of potassium-canrenoate; at the present there seems no alternative to other positive inotropic agents such as calcium, glucagon, dopamine, orciprenaline and epinephrine.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002191:Canrenoic Acid / Q000627:therapeutic use*; D002302:Cardiac Output / Q000187:drug effects; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation; D006339:Heart Rate / Q000187:drug effects; D006343:Heart Septal Defects / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D011245:Pregnadienes / Q000627:therapeutic use*
D011245:Pregnadienes; D002191:Canrenoic Acid
Extrarenale Effekte von Canrenoat-Kalium Hämodynamische Untersuchungen unter Narkosebedingungen bei herzchirurgischen Patienten.