Microvascular anastomosis using a blood product sealant-adhesive.
In this experimental model, we have shown that a four suture repair with a biologic sealant adhesive significantly reduces hemorrhage and reduces operative time, while allowing a flap survival comparable to that obtained with standard techniques in rats undergoing a microvascular anastomosis. In heparinized rats undergoing the same procedure, the sealant adhesive significantly decreases hemorrhage and increases flap survival. Of significance is the fact that the platelet-fibrinogen-thrombin adhesive is biodegradable and does not induce a tissue reaction. We believe that this physiologic adhesive may become a useful adjunct in digital reimplantation. It appears to reduce operative time and heparin-induced bleeding.
D000818:Animals; D001792:Blood Platelets; D002417:Cattle; D005340:Fibrinogen; D006470:Hemorrhage / Q000517:prevention & control; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000601:surgery*; D011183:Postoperative Complications; D051381:Rats; D013536:Suture Techniques; D013917:Thrombin; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors
D005340:Fibrinogen; D006493:Heparin; D013917:Thrombin