Stimulation of erythropoiesis in a grafted animal by mouse fetal liver culture media.
Erythropoietin given to polycythemic, irradiated mice receiving a bone marrow transplant restores the number of erythroid colonies produced. In this study mouse fetal liver culture media administered to polycythemic, irradiated mice also restored the number of erythroid colonies and erythropoiesis as measured by 59Fe incorporation. Thus, mouse fetal liver in culture produces a factor which resembles erythropoietin.
D000818:Animals; D001681:Biological Assay; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002455:Cell Division; D002999:Clone Cells; D003470:Culture Media / Q000032:analysis; D004920:Erythropoiesis; D004921:Erythropoietin / Q000008:administration & dosage / Q000032:analysis; D005260:Female; D008099:Liver / Q000196:embryology* / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011086:Polycythemia / Q000097:blood; D011830:Radiation Effects; D013154:Spleen / Q000502:physiology; D014184:Transplantation, Homologous
D003470:Culture Media; D004921:Erythropoietin