Effect of piperazine on central and peripheral cholinergic synapses of the frog.
The anthelmintic agent piperazine did not antagonize carbachol-induced depolarizations of the frog sartorius muscle but depressed root potentials and acetylcholine release from the frog spinal cord. We suggest that piperazine has a presynaptic site of action at central cholinergic nerve-terminals.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001001:Anura; D002217:Carbachol / Q000494:pharmacology; D066298:In Vitro Techniques; D010276:Parasympatholytics; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology*; D011896:Rana temporaria; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013126:Spinal Nerve Roots / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects*
D010276:Parasympatholytics; D010879:Piperazines; D002217:Carbachol; D000109:Acetylcholine