Peroperative infusion of dextran 70 and dextran 40 in the prevention of postoperative deep venous thrombosis as confirmed by the I-125-labelled fibrinogen uptake method.
The antithrombotic effect of dextran 70 and dextran 40 was studied by a double blind trial in 235 patients with major or medium sized elective procedures. 6% dextran 70 (Macrodex) or 10% dextran 40 (Rhemacrodex) or 5% dextrose in 0.9% saline were given in a double blind manner in 500 ml quantities over 30 minutes starting with the induction of anaesthesia. The diagnosis of deep venous thrombosis was confirmed objectively by the I-125-labelled fibrinogen uptake method. Statistically significant differences in the incidence of deep venous thrombosis between the controls and the dextran groups were not found.
D002986:Clinical Trials as Topic; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005340:Fibrinogen; D006801:Humans; D007263:Infusions, Parenteral; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000175:diagnosis / Q000517:prevention & control*
D003911:Dextrans; D007457:Iodine Radioisotopes; D005340:Fibrinogen