Possible occurrence and meaning of lymphocytes bearing autoanti-idiotypic receptors during the immune response.
During an immune response, the increase in binding affinity of antibodies is followed by a fall. Lymphocytes bearing autoanti-idiotypic receptors were detected during a normal immune response. The kinetics of appearance and disappearance of such lymphocytes led us to propose a network model to explain the changes occurring in antibody properties during an immune response.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000915:Antibody Affinity; D000918:Antibody Specificity; D001323:Autoantibodies; D001666:Binding Sites, Antibody; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology*; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology; D014027:Tobacco Mosaic Virus / Q000276:immunology
D000914:Antibodies, Viral; D001323:Autoantibodies