Flunarizine and cinnarizine as vestibular depressants. A statistical study.
The authors analysed the vestibular depressant activity of flunarizine and cinnarizine, as compared to a placebo, in 58 patients with peripheral labyrinthine disorders. The activity of the medications was judged by the reduction of the average velocity of the slow phase of the post-caloric nystagmus, before and after treatment. In spite of being administered in a smaller dosis, flunarizine appeared to have a more intense vestibular supressant activity, as judged by different statistical tests.
D002150:Caloric Tests; D004341:Drug Evaluation; D005133:Eye Movements / Q000187:drug effects; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D010919:Placebos; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D010879:Piperazines; D010919:Placebos