Membrane transport of antifolates as a critical determinant of drug cytotoxicity.
D000630:Aminopterin / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents; D001693:Biological Transport, Active / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005493:Folic Acid Antagonists / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008727:Methotrexate / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000378:metabolism; D013763:Tetrahydrofolates / Q000378:metabolism; D013816:Thermodynamics
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D009943:Organophosphorus Compounds; D013763:Tetrahydrofolates; D000630:Aminopterin; D008727:Methotrexate