The effect of gastric distension on the secretion of acid and pepsin by patients with duodenal ulcer.
Twentyfour patients with active duodenal ulceration were subjected to gastric distension with a balloon, in an attempt to assess the "neural tone" affecting the parietal and chief cells of the stomach. Distension stimulated gastric secretion in a manner similar to, but weaker than, pentagastrin. No evidence was found that distension provides a specific "neural" stimulus to the gastric secretion of acid or pepsin in man.
D000328:Adult; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D009129:Muscle Tonus; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D010812:Physical Stimulation; D011312:Pressure; D012636:Secretory Rate / Q000187:drug effects
D010434:Pepsin A; D010418:Pentagastrin