Fluorescein angiography of the corneal limbus--drug effects on capillary blood flow.
By means of fluorescein angiography, plasma flow through the capillaries at the limbus corneae is demonstrated. The number of stained capillaries at a given time served as a measure of capillary perfusion. Even without drug the entire capillary system is perfused at least by plasma. Tolazoline enhanced the velocity of perfusion (P = 2alpha less than 0.01), epinephrine caused a marked capillary constriction (P = 2alpha less than 0.01), as well as--to a lesser extent--did dexamethasone (P = 2alpha less than 0.05). Dionine caused hyperemia, but the data varied much more than after tolazoline. In addition, dionine enhanced the dye leakage from the vessels.
D000328:Adult; D002196:Capillaries / Q000187:drug effects; D003315:Cornea / Q000098:blood supply*; D003907:Dexamethasone / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005036:Ethylmorphine / Q000494:pharmacology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D014043:Tolazoline / Q000494:pharmacology
D003907:Dexamethasone; D014043:Tolazoline; D005036:Ethylmorphine; D004837:Epinephrine