De novo purine ribonucleotide biosynthesis in adult Angiostrongylus cantonensis (Nematoda: Metastrongyloidea).
1. Radioactivity was found to be associated with purine ribonucleotides in extracts of gravid adult Angiostrongylus cantonensis from the lungs of rats when the parasite was incubated in a medium containing [14C]glycine. 2. The rate of incorporation was at least 0.2 pmole/min per mg of parasite and approximately equal amounts of adenine and guanine ribonucleotides were synthesized. 3. This is the first demonstration of the capacity for a mammalian parasitic helminth to synthesize purines de novo.
D000225:Adenine / Q000378:metabolism; D000241:Adenosine / Q000378:metabolism; D000801:Angiostrongylus / Q000378:metabolism*; D000818:Animals; D005260:Female; D006147:Guanine / Q000378:metabolism; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007288:Inosine / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008681:Metastrongyloidea / Q000378:metabolism*; D011685:Purine Nucleotides / Q000096:biosynthesis*
D007042:Hypoxanthines; D011685:Purine Nucleotides; D019271:Hypoxanthine; D007288:Inosine; D006147:Guanine; D000225:Adenine; D000241:Adenosine