[Chronic persistent HBsAg positive hepatitis in children. II. Effect of treatment with levamisole].
In five children affected by HBsAg positive chronic persistent hepatitis a treatment with Levamisole (LMS) modified several immunological parameters which had been found altered before treatment. In particular the percentage of E rosette forming cells increased while that of EAC decreased; B lymphocytes with SmIgG and the responsiveness to phytohaemagglutinin, which were significantly decreased and increased respectively, got normal values. Since the persistence of HBsAg was unaffected by LMS treatment and a light increase of transaminase serum levels (GPT and GOT) was observed during treatment, doubts are expressed about the opportunity of using LMS in children affected by such a form of hepatitis.
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy* / Q000276:immunology; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D037102:Lectins / Q000494:pharmacology; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation
D006514:Hepatitis B Surface Antigens; D007074:Immunoglobulin G; D037102:Lectins; D011947:Receptors, Antigen, B-Cell; D007978:Levamisole; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Epatite cronica persistente HBsAg positiva in eta' pediatrica. NOTA II. Effetto di un trattamento con levamisole.