relA gene control of the synthesis of lipid A fatty acyl moieties.
The incorporation of [14C]acetate into the fatty acid moieties of lipid A was measured during amino acid starvation of rel+ and relA strains of Escherichia coli K-12. The synthesis of the beta-hydroxymyristate and other fatty acid moieties was inhibited two- to fourfold in rel+ strains, whereas no inhibition was observed in relA strains. The fatty acid compositions of the phospholipids synthesized after amino acid starvation or rel+ and relA strains were also determined.
D000085:Acetates / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis / Q000096:biosynthesis; D005796:Genes; D008055:Lipids / Q000096:biosynthesis*; D009227:Myristic Acids / Q000096:biosynthesis*; D010743:Phospholipids / Q000032:analysis / Q000096:biosynthesis
D000085:Acetates; D000596:Amino Acids; D005227:Fatty Acids; D008055:Lipids; D009227:Myristic Acids; D010743:Phospholipids