title: Effects of 16,16 dimethyl prostaglandin E2 on food-stimulated pancreatic secretion and output of bile in man.
abstract: The effect of 140 microgram 16,16 dimethyl prostaglandin E2 on food-stimulated pancreatic and biliary response has been studied in 7 healthy subjects, using a multiple indicator dilution technique. Intragastic administration of the methyl analogue decreased significantly the pancreatic and the biliary response, despite an enhanced gastric emptying rate of the test meal.
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D005215:Fasting; D005502:Food; D005750:Gastric Juice / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007201:Indicator Dilution Techniques; D008049:Lipase / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D012636:Secretory Rate
chemical_list: D011458:Prostaglandins E; D008049:Lipase; D001663:Bilirubin