Human and guinea-pig cross-reacting spermatozoa autoantigens and autoantibodies.
Cross-reactivity between human and guinea-pig spermatozoa autoanigens has been studied in two systems: (1) guinea-pig anti-autoantigens S, P and T immune sera reacting on human spermatozoa and (2) activity of human anti-sperm sera on guinea-pig spermatozoa. These assays, as well as the results of cross-absorptions in the two systems, revealed a close antigenic relationship between the two species of spermatozoa concerning the guinea-pig autoantigen S. However, there were some differences in its localization and serological manifestations in both species. The guinea-pig autoantigen T bore a more distant, though definite, relationship with human spermatozoa. No clear evidence of cross-reactivity between the two species was found for autoantigen P. At variance with autoimmune (or isoimmune) human antibodies, 'natural' human antibodies active on guinea-pig spermatozoa were absorbed by guinea-pig spleen cells.
D000818:Animals; D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D013045:Species Specificity; D013073:Sperm Agglutination; D013094:Spermatozoa / Q000276:immunology*
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens