Molecular specificity of x-radiation and its repair in Saccharomyces cerevisiae.
Molecular specificity of soft X-radiation has been studied in yeast by analyzing the transitions UAA in equilibrium UAG and nonsense leads to sense mutations in the codon tyr7-1. Synchronized cell populations in the most radiosensitive and radioresistant stages were compared: they did not show any qualitative or quantitative differences in their sensitivities to the mutagenic action of X-rays. We conclude that repair mechanisms, which remain unexpressed in the sensitive cells, do not affect point mutations of the base-substitution type.
D003062:Codon / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006824:Hybridization, Genetic; D009154:Mutation; D012333:RNA, Messenger / Q000528:radiation effects*; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000528:radiation effects*; D013045:Species Specificity
D003062:Codon; D012333:RNA, Messenger