title: [In vitro activity of cefaclor against Haemophilus influenzae in comparison to various oral chemotherapeutic agents (author's transl)].
abstract: The antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of Haemophilus influenzae was compared with that of cephalexin, ampicillin, chloramphenicol, tetracycline and co-trimoxazole. A new standardized microtiter dilution technique was used. Cefaclor showed greater activity than did cephalexin and inhibited beta-lactamase producing H. influenzae isolates. Ampicillin was the most active compound against non-beta-lactamase producing isolates. One of our strains was resistant to chloramphenicol and one resistant to tetracycline.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D002433:Cefaclor / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000187:drug effects*; D010403:Penicillin Resistance; D001618:beta-Lactamases
chemical_list: D002433:Cefaclor; D000667:Ampicillin; D001618:beta-Lactamases; D002506:Cephalexin
vernacular_title: In-vitro-Aktivität von Cefaclor gegen Haemophilus influenzae im Vergleich zu verschiedenen oralen Chemotherapeutika.