Activation of human lymphocyte subpopulations by protein A from Staphylococcus aureus bacteria.
Cowan I strain Staphylococcus aureus bacteria were found to be mitogenic for human peripheral and cord blood lymphocytes. Experiments with lymphocyte supopulations otained by nylon wool filtration and/or E-rosette separation revealed that T-lymphocytes are the main target cells, whereas isolated B cells did not respond significantly. Further experiments suggested that B cells could be activated in the presence of mitomycin-treated T cells. Null cell-enriched lymphocyte suspensions could be stimulated by Con A but not by the bacteria or by PHA.
D001402:B-Lymphocytes / Q000187:drug effects*; D005312:Fetal Blood; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008937:Mitomycins; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects*
D008937:Mitomycins; D013205:Staphylococcal Protein A