Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
Injection of emulsified trehalose-6,6'-dimycolate (TDM), a mycobacterial glycolipid, into transplants of an established, syngeneic murine fibrosarcoma induced complete regression of tumor in a number of animals. The number of animals in wich tumor regressed completely depended on the amount of oil in the emulsion. The anti-tumor activity of the TDM emulsion containing the highest concentration of oil was equivalent to that of living BCG.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001500:BCG Vaccine; D003311:Cord Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D005260:Female; D006017:Glycolipids / Q000627:therapeutic use*; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009163:Mycobacterium bovis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009821:Oils; D014199:Trehalose
D000970:Antineoplastic Agents; D001500:BCG Vaccine; D003311:Cord Factors; D004655:Emulsions; D006017:Glycolipids; D009821:Oils; D014199:Trehalose