Therapy of murine aspergillosis with amphotericin B in combination with rifampin of 5-fluorocytosine.
Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradicated infections in the mice when evaluated by mycological culture, even in long-term survivors.
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D003596:Cytosine / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use*; D051379:Mice; D008806:Mice, Inbred AKR; D012293:Rifampin / Q000627:therapeutic use*
D000666:Amphotericin B; D003596:Cytosine; D005437:Flucytosine; D012293:Rifampin