Effects of the antiprotease Trasylol on peripheral blood leucocytes.
Binding of the antiprotease Trasylol to human peripheral blood lymphocytes and polymorphonuclear leucocytes (PMNs) was demonstrated at the ultrastructural level using an indirect immunoperoxidase technique. This also revealed endocytosis of membrane bound Trasylol by PMNs. Trasylol inhibited PHA- and ConA-induced lymphocyte stimulation, and was cytotoxic to unstimulated cells.
D007611:Aprotinin / Q000494:pharmacology*; D001665:Binding Sites; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D009504:Neutrophils / Q000187:drug effects* / Q000648:ultrastructure; D010544:Peroxidases
D007611:Aprotinin; D010544:Peroxidases