[Effect of polyenic antibiotics on the activity of alkaline phosphatase from Candida albicans].
Polyenic antibiotics (levorin, amphotericin B, nistatin) inhibit in vivo and in vitro the activity of membrane alkaline phosphatase from sensitive Candida albicans strain, and their inhibitory effect is twice lower on the enzyme from the resistant strain. A correlation is observed between the antibiotic concentration and the inhibitory effect on alkaline phosphatase activity. Nistatin is found to be the least efficient inhibitor (among the antibiotics studied) of alkaline phosphatase. The treatment of membranes with polyenic antibiotics does not result in solubilization of membrane proteins nad alkaline phosphatase. The data obtained are considered with respect to the effect of polyenic antibiotics on cell membrane structure.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors*; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology; D002176:Candida albicans / Q000201:enzymology*; D002462:Cell Membrane / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008566:Membranes / Q000201:enzymology; D009761:Nystatin / Q000494:pharmacology; D013045:Species Specificity
D000935:Antifungal Agents; D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B; D000469:Alkaline Phosphatase
Deĭstvie polienovykh antibiotikov na aktivnost' shchelochnoĭ fosfatazy membrannoĭ fraktsii kletok Candida albicans