Effects of intravenous bolus dosages of methylprednisolone and local radiation on renal allograft rejection and patient mortality.
One hundred and thirty of 179 rejection episodes encountered in 205 transplants were reversed by treatment with a bolus preparation of methylprednisolone. Ninety-six of these episodes also required an increase in oral prednisone dosage. No beneficial effect on over-all graft survival was noted, but a significant rise in the mortality, secondary to sepsis, was noted in those who received more than 5 grams of methylprednisolone. Local radiation to the graft did not contribute to better graft survival or mortality.
D003037:Cobalt Radioisotopes / Q000008:administration & dosage; D006084:Graft Rejection / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D007275:Injections, Intravenous; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology; D011878:Radiotherapy / Q000009:adverse effects; D014184:Transplantation, Homologous / Q000401:mortality
D003037:Cobalt Radioisotopes; D008775:Methylprednisolone