[Immunocytochemical localization of gliofibrillary proteins (GDAP) in human cerebral tumors. Histological and in vitro studies].
On the basis of studies utilizing antibody to GFAP (glial fibrillary acidic protein) in the indirect immunofluorescent and immunoperoxydase methods we report the presence of GFAP in 5 astrocytomas, 1 ependymoma and 1 medulloblastoma. The GFAP was evidenced on cryostat sections of frozen material and in short-term tissue culture. Five others tumors including 1 oligodendrocytoma, 1 choroid-plexus papilloma, 1 meningioma and 2 secondary sarcomas were negative. Possible applications of antibodies to GFAP for localization and therapy of brains tumors were considered.
D000941:Antigens; D001253:Astrocytes / Q000276:immunology / Q000473:pathology; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D046508:Culture Techniques; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D007158:Immunologic Techniques; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism; D009457:Neuroglia / Q000276:immunology
D000941:Antigens; D007106:Immune Sera; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins
Localisation de la protéine gliofibrillaire (GFAP) par immunocytochimie dans les tumeurs cérébrales humaines. Etude histologique et en culture in vitro.