Comparison of enzyme-cytochemical findings and immunological marker investigations in acute lymphatic leukemia (ALL).
APh-activity and PAS-positive deposits were studied in 50 cases of ALL, classified as T-ALL and O-ALL according to immunological marker investigations. Correlation between morphological features of the cells and APh and PAS reactions, as well as between morphology and immunological markers was not detected. APh-activity in general was stronger in T-ALL (R+ and R-), while PAS-content was more pronounced in O-ALL. The results suggest that cytochemical methods, especially APh and PAS reaction, are valuable to distinguish T-ALL from O-ALL but not reliable enough to replace immunological marker investigations.
D000135:Acid Phosphatase / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D002462:Cell Membrane; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000276:immunology*; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D013601:T-Lymphocytes
D000135:Acid Phosphatase