Normal T-lymphocyte function in psoriatic patients undergoing methoxsalen photochemotherapy.
Peripheral blood lymphocytes from psoriatic patients undergoing photochemotherapy using oral 8-methoxypsoralen and high-intensity long-wave ultraviolet radiation, were isolated and their ability to respond to phytohemagglutinin and to form spontaneous rosettes with sheep red blood cells was measured in vitro. Seventeen patients were investigated who had received 200 to 3700 Joules/cm2 of ultraviolet radiation over a 6- to 33-month period. No significant defects in lymphocyte blastogenesis or E-rosette formation were detected in these patients.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000009:adverse effects*; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000503:physiopathology / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D008730:Methoxsalen