title: The medical treatment of secretory otitis media. A clinical trial of three commonly used regimes.
abstract: A clinical trial was undertaken to evaluate three medical treatments commonly used for chronic secretory otitis media. The treatments compared were Ephedrine nose drops, an oral antihistamine and decongestant (Dimotapp) and autoinflation of the middle ear. Changes in middle ear compliance and pressure were used as objective criteria of the efficacy of treatment in addition to changes in pure-tone threshold and to clinical assessment. Symptoms and abnormal signs tended to remit during the trial but there was no evidence from pure-tone audiometry and tympanometry that any of the treatments was beneficial. The period of observation enabled 28% of the children to avoid surgical treatment. Good and bad prognostic features are described which should help in deciding whether to manage a case conservatively or whether to proceed directly to surgery.
mesh_terms: D001977:Brompheniramine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004432:Ear, Middle / Q000503:physiopathology; D004809:Ephedrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D010656:Phenylephrine / Q000627:therapeutic use; D010665:Phenylpropanolamine / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D010656:Phenylephrine; D010665:Phenylpropanolamine; D004809:Ephedrine; D001977:Brompheniramine