Metabolism of p-aminobenzoic acid in the perfused livers of chronically uraemic rats.
1. Chronic renal failure was induced in rats by surgical removal of thirteen-sixteenths of renal tissue. 2. The metabolism of p-amino[14C]benzoic acid was studied in the isolated perfused livers of control and chronically uraemic rats. There was a slower rate of clearance and decreased overall metabolism of the compounds in the uraemic rats. 3. Conjugation of p-amino[14C]benzoic acid with glycine and the formation of p-aminobenzoic acid glucuronide were both significantly decreased in the uraemic rats, but there was a significant increase in acetylation of both p-aminobenzoic acid and its glycine conjugate.
D010129:4-Aminobenzoic Acid / Q000378:metabolism*; D000107:Acetylation; D062365:Aminobenzoates / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D014511:Uremia / Q000378:metabolism*
D062365:Aminobenzoates; D005965:Glucuronates; D005998:Glycine; D010129:4-Aminobenzoic Acid