Vincristine effect on methotrexate cerebrospinal fluid concentration.
A 67-year-old man with malignant lymphoma, nodular, poorly differentiated lymphocytic type, developed meningeal lymphomatosis. Repeated high-dose methotrexate-citrovorum factor treatment (1 g/m2 in 24 hours) rendered the patient free of disease. The administration of vincristine at 23 hours consistently increased the concentration of methotrexate in the cerebrospinal fluid 2.5-fold above baseline values.
D000368:Aged; D004347:Drug Interactions; D006258:Head and Neck Neoplasms / Q000134:cerebrospinal fluid / Q000188:drug therapy; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008223:Lymphoma / Q000134:cerebrospinal fluid / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology* / Q000627:therapeutic use
D014750:Vincristine; D002955:Leucovorin; D008727:Methotrexate