B cell activating properties of parotid protein.
A new biological activity of bovine parotid protein acting on immuno-competent lymphocytes to lead to polyclonal antibody responses was demonstrated. A significant amount of antibody to SRBC or antihapten antibody to TNP-SRBC, BPO-SRBC, or SA-SRBC was produced in mice by adding the appropriate doses of bovine parotid protein, suggesting that this protein may be a nonspecific B cell activator which acts on the B cells in a similar way as casein or gelatin.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002417:Cattle; D002999:Clone Cells / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006728:Hormones / Q000494:pharmacology*; D008213:Lymphocyte Activation; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D010306:Parotid Gland; D012471:Salivary Proteins and Peptides / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D006728:Hormones; D012471:Salivary Proteins and Peptides