Characterization of thymosin-responsive peripheral blood null cells.
Suspensions of human peripheral blood lymphocytes were enriched for E rosette-negative (E-) surface immunoglobulin-negative (SIg-) "null" cells expressing either human T or human B lymphocyte antigens. These enriched suspensions were then tested for responsiveness to activation of E rosette formation by thymosin. Thymosin activated some human T lymphocyte antigen-positive E-SIg- but not human B lymphocyte antigen-positive E-SIg- cells to form E rosettes. Therefore, thymosin-responsive peripheral blood null cells appear to be precommitted to the T- cell line of differentiation.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002648:Child; D006680:HLA Antigens; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D011947:Receptors, Antigen, B-Cell; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D013947:Thymosin / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D006680:HLA Antigens; D011947:Receptors, Antigen, B-Cell; D013951:Thymus Hormones; D013947:Thymosin