Characterization of mononuclear cell infiltrates in psoriatic lesions.
The dermal mononuclear cell infiltrates of psoriatic lesions were characterized by receptors for sheep erythrocytes (T-lymphocytes), C3b receptors (macrophages and B-lymphocytes) and C3d receptors (B-lymphocytes), using hemadsorption to cryostat sections in a closed chamber. T-lymphocytes and macrophages were the predominant inflammatory cells. Very few B-lymphocytes were detected. These findings are discussed in relation to the possible pathogenetic signficance of cellular immunity in psoriasis.
D001402:B-Lymphocytes / Q000276:immunology; D001665:Binding Sites; D003179:Complement C3b; D006801:Humans; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D003179:Complement C3b