[Effect of carminomycin on the immunological reactivity of the body].
The morpho-functional state of the muscle lymphoid tissue of mice treated with karmionmycin (LD50, 1.1 mg/kg) was studied experimentally. Development of a number of changes evident of the cell disorganization in the lymphoid tissue was shown. The cytological shifts in the thymus and spleen were reversible, while the destructive period in the strumous gland was more prolonged. The morpho-structural normalization of the spleen did not coincide with reduction of its immunological function. The studies on the karminomycin effect on the kinetics of the primary immune response showed dependence of the antibiotic effect on the temporal ratio between the antigenic stimulus and the drug administration. The antibiotic had no effect on the inductive phase of the primary immune response but significantly suppressed its productive phase. On reproduction of the secondary immune response, a decrease in the content of the antibody-forming cells in the spleen was observed, production of the circulating antibodies remaining unchanged.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002360:Carubicin / Q000276:immunology*; D006388:Hemagglutinins / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007700:Kinetics; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects; D051379:Mice; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D006388:Hemagglutinins; D002360:Carubicin
Vliianie karminomitsina na immunologicheskuiu reaktivnost' organizma.