Inhibition of B-cell function by concanavalin-A-induced suppressor cells.
The in vitro immune response of normal spleen cells to the thymus-independent antigen dinitrophenylated levan (DNP-LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti-sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con-A-induced suppressor cell activity.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology*; D004136:Dinitrobenzenes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D007165:Immunosuppression Therapy; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep; D013154:Spleen / Q000276:immunology
D004136:Dinitrobenzenes; D003208:Concanavalin A