title: Aspirin intolerance--a review.
abstract: 1. Association of bronchial asthma, nasal pathology and intolerance to aspirin is a unique syndrome. Aspirin-induced prolongation of bleeding time, and a tendency for diabetes, may exist with it. 2. The syndrome occurs most often in the middle-aged female. 3. Progression of asthma and nasal polyposis is not prevented by avoidance of aspirin. 4. Salicylates other than aspirin are well tolerated but cross-reactivity with other analgesics, and with tartrazine, may occur. 5. The underlying mechanism is unknown. An immunologic basic is most unlikely.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000799:Angioedema / Q000139:chemically induced; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000209:etiology; D001777:Blood Coagulation / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D048909:Diabetes Complications; D004802:Eosinophilia / Q000139:chemically induced; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000139:chemically induced / Q000150:complications; D011236:Prediabetic State / Q000150:complications; D006255:Rhinitis, Allergic, Seasonal / Q000139:chemically induced; D012737:Sex Factors; D012769:Shock / Q000139:chemically induced; D014474:Unconsciousness / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced
chemical_list: D001241:Aspirin