[Action of ftorafur and 5-fluorouracil on the chromosomes of normal and tumorous cells in vivo].
No chromosome aberrations were found in the bone marrow cells and Djungarian hamster tumor cells and bone-marrow cells of thymectomized mice receiving different doses of fluorafur and 5-fluoruracil in vivo. The time of exposure to these antitumor drugs varied from 2 to 72 hours. 12% of aberrant metaphases under 400 mg/Kg of fluorafur and 38%--under 200 mg/Kg of 5-fluoruracil were found in cells of human colonic tumor trasplanted into thymectomized mice.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008938:Mitosis / Q000187:drug effects; D009368:Neoplasm Transplantation; D005641:Tegafur / Q000494:pharmacology*; D013934:Thymectomy; D013997:Time Factors
D005641:Tegafur; D005472:Fluorouracil
Deĭstvie ftorafura i 5-ftoruratsila na khromosomy normal'nykh i opukholevykh kletok in vivo