Buprenorphine: a new potent long-acting synthetic analgesic. Comparison with morphine.
A new thebaine derivative, buprenorphine, 0.6 mg, was compared with morphine 15 mg in a  double-blind trial, in patients recovering from elective Caesarean section. Within 1 h of administration analgesia was obtained with both drugs and was sustained for 7-8 h with buprenorphine, and 3-4 h with morphine. Buprenorphine caused a greater decrease in diastolic arterial pressure than did morphine, but arterial systolic pressure and heart rate were not influenced by either drug. No serious side-effects were encountered in this study.
D002585:Cesarean Section; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009019:Morphinans / Q000627:therapeutic use*; D009020:Morphine / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects
D009019:Morphinans; D009020:Morphine