Functional and surface characterisitics of lymphocytes from patients with warm-antibody type autoimmunhemolytic anemia (AIHA).
As part of an overall assessment of immunological function, several aspects of cellular immunity and circulating lymphocyte subpopulations were evaluated in a group of 10 patients with idiopathic autoimmunhemolytic anemia (AIHA). The absolute numbers of circulating T and B cells were reduced in the patient group compared to normals. A shift from "corticosteroid-sensitive" to "corticosteroid-resistent" and activated cells in the cytogram of clustered Fe-(III)-hydroxide-glucane saccharose labeled T lymphocytes was apparent. In vitro studies of cellular reactivity, as evaluated by PHA, ConA, PWM, antigens and allogeneic cell induced proliferation showed a blend of general or selective depression and sometimes a normal or increased activity with no definite correlation with both the number of circulating T cells and the extent of the hemolytic activity by the disease. The possible significance of the findings is discussed.
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000921:Antibody-Producing Cells / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D007111:Immunity, Cellular; D051379:Mice; D008814:Mice, Inbred NZB; D012397:Rosette Formation; D013499:Surface Properties; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D003208:Concanavalin A