The cadaver kidney transplantation programme of Milano. Immunological report.
A retrospective investigation was carried out to evaluate the infuence of HLA (A, B) matching, blood transfusions, and preexistence of lymphocytotoxic antibodies on the outcome of the cadaver kidney graft: only non-NIH standard antibodies were considered, since patients with NIH standard antibodies do not undergo transplantation in the programme of Milano. It was found that (1) about one-half the patients with transplants had antibodies in their pretransplant serum. The preexistence of antibodies directed against B lymphocytes had an unfavourable effect on the graft survival; (2) the graft did particularly well in the nonimmunized patients who had been previously transfused; the graft survival was about 80% at 3 years in these patients; and (3) the HLA (A, B) match influenced the graft survival only in patients with antibodies.
D000906:Antibodies; D001803:Blood Transfusion; D002102:Cadaver; D003601:Cytotoxicity Tests, Immunologic; D006085:Graft Survival; D006801:Humans; D007558:Italy; D016030:Kidney Transplantation; D008233:Lymphotoxin-alpha; D009026:Mortality; D014184:Transplantation, Homologous
D000906:Antibodies; D008233:Lymphotoxin-alpha