Simple and compact cannula system for mice.
A small and simple device is described for applying substances to the brain of freely moving mice. The effectiveness of the technique was evaluated by intraventricular injections of d-amphetamine sulfate. It was observed that intraventricular injections of d-amphetamine (50-200 microgram) produced a dose dependent increase in activity.
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002404:Catheterization / Q000295:instrumentation / Q000662:veterinary*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular / Q000295:instrumentation / Q000662:veterinary*; D051379:Mice / Q000033:anatomy & histology*; D009043:Motor Activity / Q000187:drug effects; D013238:Stereotaxic Techniques; D013997:Time Factors
D003913:Dextroamphetamine