Comparison of side effects with coated lithium carbonate tablets and lithium sulphate preparations giving medium-slow and slow-release.
Side effects with coated, rapidly dissolving lithium carbonate tablets, medium-slow-release and slow release lithium sulphate tablets, all administered twice a day, were compared in a double-blind, cross-over study in 27 patients who had only used lithium carbonate tablets. The relation between medication and meals was not standardized. The repidly dissolving tablets and the medium-slow-release tablets had a similar tendency to produce side effects, while slow-release tablets more often produced purgative side effects than the other two preparations did.
D000328:Adult; D002254:Carbonates; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D003967:Diarrhea / Q000139:chemically induced; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D013431:Sulfates; D013608:Tablets, Enteric-Coated; D014717:Vertigo / Q000139:chemically induced
D002254:Carbonates; D003692:Delayed-Action Preparations; D013431:Sulfates; D013608:Tablets, Enteric-Coated; D008094:Lithium