title: [Test-strains of E. coli for detection of chemical mutagens].
abstract: Two temperature-sensitive mutants--AP 16 and AP 18 were isolated after the treatment of E. coli AB2500 strain with two mutagens (acridine orange and 5-bromuracil). The mutants obtained proved to be sensitive and formed revertants when treated with the following agents: N-methyl-N'-nitro-N-nitrosoguanidine, hydroxylamine, nitrous acid, sodium metabisulfite, methylmethansulfonate, and proflavine. Introduction into the mentioned strains of additional mutation causing elevation of their sensitivity to crystal violet increased somewhat their capacity to form revertants under the effect of proflavine and methylmethansulfonate.
mesh_terms: D004926:Escherichia coli / Q000187:drug effects; D006898:Hydroxylamines / Q000494:pharmacology; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009153:Mutagens / Q000032:analysis* / Q000494:pharmacology; D009608:Nitrous Acid / Q000494:pharmacology; D011370:Proflavine / Q000494:pharmacology
chemical_list: D006898:Hydroxylamines; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D008741:Methyl Methanesulfonate; D011370:Proflavine; D009608:Nitrous Acid
vernacular_title: Test-shtammy E. coli dlia obnaruzheniia khimicheskikh mutagenov.