Simultaneous in situ carcinoma of the cervix, vulva and perineum after immunosuppressive therapy for renal transplantation.
A 31-year-old woman developed multiple synchronous in situ carcinomas of the cervix uteri, vulva and perineal skin, six years after successful renal transplantation for chronic renal failure due to chronic pyelonephritis. During this time she had been continuously treated with immunosuppressive drugs (azathioprine and prednisolone). The lesions were treated by local excision and there was no evidence of recurrence nearly two years after the primary treatment. The case history is compared to others recently described and highlights the risk of epithelial as well as lymphomatous malignancies in renal transplant recipients.
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D002278:Carcinoma in Situ / Q000209:etiology*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D010502:Perineum / Q000473:pathology; D011239:Prednisolone / Q000009:adverse effects; D014184:Transplantation, Homologous; D002583:Uterine Cervical Neoplasms / Q000209:etiology*; D014846:Vulvar Neoplasms / Q000209:etiology*
D011239:Prednisolone; D001379:Azathioprine