[Comparative study of bacterial agmatinase inhibition by derivatives of putrescine and aliphatic monoamines].
Aliphatic monoamines and some putrescine derivatives (10(-3) M) are found to inhibit agmatinase from Proteus vulgaris. Constants and the type of inhibition are determined. Investigation of the temperature effect on the inhibition has revealed an exotermic character of this process. Some thermodinamic parameters of agmatinase-anylamine binding reaction are calculated. 1-Guanidobutane is obtained by means of 1-amidobutane guanidilation, and it is found to be more efficient inhibitor than monoamines.
D000376:Agmatine; D000588:Amines / Q000494:pharmacology*; D002384:Catalysis; D007700:Kinetics; D011514:Proteus vulgaris / Q000201:enzymology*; D011700:Putrescine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013696:Temperature; D013816:Thermodynamics; D014512:Ureohydrolases / Q000037:antagonists & inhibitors*
D000588:Amines; D000376:Agmatine; D014512:Ureohydrolases; D011700:Putrescine
Sravnitel'noe izuchenie ingibirovaniia bakterial'noĭ agmatinazy proizvodnymi putrestsina i alifaticheskimi monoaminami