[Change in the immunological indices in arteriosclerosis].
Fifty-nine patients with stage I (according to A. L. Myasnikov's classification) coronary atherosclerosis and 23 healthy persons of the same age were tested for the content of rosette-forming T- and B-lymphocytes, immunoglobulin classes, lymphocyte blast-cell transformation reaction to the phage and antigen from the normal and atherosclerotic aorta, and the changes in these indices under the effect of miscleron (in 23) and acetylsalicylic acid (in 10 persons). A tendency to an increase in the content of B-lymphocytes and G and A immunoglobulins and intensification of the lymphocyte blast-cell transformation reaction to an antigen from the sclerotic aorta, and a tendency to a decrease in the content of T-lymphocytes in patients with atherosclerosis were noted. The normalizing effect of miscleron therapy on these indices with parall improvement in the values of lipid metabolism were also established. Acetylsalicylic acid did not change the values of lipid metabolism and had not effect on the blood immunoglobulin content.
D000208:Acute Disease; D001402:B-Lymphocytes / Q000276:immunology; D003327:Coronary Disease / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Ob izmenenii nekotorykh immunologicheskikh pokazateleĭ pri ateroskleroze.