Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.
The heterogeneity of avidity of DNP-binding (rosetting) cells has been studied in mice of various ages, in an attempt to learn more about the development of antibody diversity. The results indicate that during the neonatal period murine B cells show a limited heterogeneity of avidity with no "high" avidity ABC being detectable. This implies that the full repertoire of anti-DNP antibodies is only gradually acquired during ontogeny. The results are interpreted as favouring the hypothesis that somatic events are important in the generation of antibody diversity.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000918:Antibody Specificity; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D051379:Mice; D012397:Rosette Formation
D000941:Antigens