[Effect of thymectomy on induction of immunologic tolerance in the effectors of delayed hypersensitivity].
The influence of thymectomy (Tx) on induction of tolerance of delayed type hypersensitivity effectors (DHE) was examined. Tx did not interfere with induction of tolerance to sheep red blood cells (SRBC) achieved with combined injections of the massive dose of the antigen and cyclophosphamide (Cy). Tx resulted in prolongation of unresponsiveness. The injection of mice with the massive dose of SRBC alone also resulted in tolerance formation. However, this type of tolghtly depressed formation of DHE in intact but not in Cy treated mice. The results obtained are in agreement with the idea of the existence of diverse mechanisms of tolerance induction (clonic-deficient and suppressor). These data also suggest the existence of two subpopulations differing in susceptibility to Cy and Tx in DHE effectors and their precursors.
D000818:Animals; D015478:Antigens, Heterophile / Q000276:immunology; D003520:Cyclophosphamide / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D012756:Sheep; D013934:Thymectomy
D015478:Antigens, Heterophile; D003520:Cyclophosphamide
Vliianie timéktomii na formirovanie immunologicheskoĭ tolerantnosti v éffektorakh giperchuvstvitel'nosti zamedlennogo tipa.