Normal B-lymphocyte function in patients with Lesch-Nyhan syndrome and HGPRT deficiency.
Immunological and biochemical studies were carried out in two patients with the Lesch-Nyhan syndrome. No abnormalities of T- or B-lymphocyte function could be demonstrated in the presence of hypoxanthine-guanine phosphoribosyl transferase (HGPRT) deficiency.
D000293:Adolescent; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency*; D007926:Lesch-Nyhan Syndrome / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D007041:Hypoxanthine Phosphoribosyltransferase