[Interaction of T- and B-cells in the secondary response to ram erythrocytes in mice of different ages].
The spleen cells from old primed donors were found to produce lesser secondary response, as compared with the cells of young animals, in the system of adaptive transfer on the CBA mice. In the experiments with extermination of T-or B-cell population in the cell suspension by means of theta-or anti-b-sera it was established that the memory to the antigen used (ram ethyrocytes) was carried by both T- and B-cells but the T-cell component played the leading role in this system. The primed cells from old animals proved to be more sensitive to defects of cellular interactions.
D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D007114:Immunization; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014181:Transplantation Immunology
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