title: A controlled study of ANA+ RF- arthritis.
abstract: Thirty (7.5%) of 401 adult rheumatoid arthritis (RA) patients were antinuclear antibody positive (ANA+) and rheumatoid factor negative (RF-), and 15 of 16 patients who were followed for a year or longer remained so. Clinical, other laboratory, and radiographic parameters were compared among this group and 90 matched RA controls divided into ANA+RF+, ANA-RF+, and ANA-RF- groups. All groups were identical, except the ANA-RF- group, which had significantly fewer nodules and less destructive disease than the other three.
mesh_terms: D000367:Age Factors; D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D005531:Foot Deformities, Acquired / Q000000981:diagnostic imaging / Q000209:etiology; D006227:Hand Deformities, Acquired / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000209:etiology; D010998:Pleurisy / Q000209:etiology; D011859:Radiography; D012217:Rheumatoid Factor / Q000032:analysis; D013997:Time Factors; D014657:Vasculitis / Q000209:etiology
chemical_list: D000974:Antibodies, Antinuclear; D012217:Rheumatoid Factor