title: Treatment of complicated urinary tract infections with amikacin: comparison of low and high dosage.
abstract: A randomized prospective study was carried out comparing the recommended dose of amikacin sulfate (Amikin) (15 mg./Kg.) with a lower dose (7.5 mg./Kg.) in the treatment of complicated urinary tract infections. A total of 50 patients were entered in the study over a period of sixteen months. Bacteriologic results were comparable in both groups. Laboratory values remained normal with the exception of 1 patient in the high-dose group who had renal insufficiency. No evidence of ototoxicity was recorded. Our data indicate that low dosage amikacin sulfate is satisfactory in the treatment of complicated urinary tract infections.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011511:Proteus / Q000302:isolation & purification; D011549:Pseudomonas / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D007612:Kanamycin; D000583:Amikacin