Peritoneal dialysis clearance of cimetidine.
Peritoneal dialysis clearance of cimetidine was determined in two patients undergoing peritoneal dialysis treatment. The peritoneal dialysis clearance of cimetidine was approximately 10 ml./min. under optimal dialyzing conditions. The average cimetidine to creatinine extraction ratio was 0.45, which represents significant peritoneal dialyzability. The amount of cimetidine removed, however, constituted only a small fraction of the total administered dose. Therefore, only minor dose adjustments may be necessary during peritoneal dialysis treatment.
D000328:Adult; D002927:Cimetidine / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006146:Guanidines / Q000378:metabolism*; D006801:Humans; D008297:Male; D010530:Peritoneal Dialysis
D006146:Guanidines; D002927:Cimetidine; D003404:Creatinine