Effects of lymphokines on fibrinolysis and kinin generation in human plasma.
Supernatants from Con-A-stimulated human lymphocytes containing leukocyte migration inhibitory factor, skin reactive factor and procoagulant activities were tested for their effect on fibrinolysis and kinin generation. The supernatants of stimulated lymphocytes activated the fibrinolysis and generated kinin in human plasma. These results are discussed from the aspect of cell-mediated (type IV) immune inflammation.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006168:Guinea Pigs; D006801:Humans; D007705:Kinins / Q000097:blood*; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000494:pharmacology*; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology; D008297:Male
D007705:Kinins; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D003208:Concanavalin A