Antithyroglobulin (ATG) production by peripheral blood leukocytes in vitro.
Antithyroglobulin is produced in vitro by pokeweed mitogen stimulation of peripheral blood lymphocytes from patients whose serum contains the autoantibody. Antithyroglobulin synthesis requires T lymphocyte help but is suppressed by larger numbers of T lymphocytes. T cells from both patients and normals perform both of these functions.
D000917:Antibody Formation; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D008934:Mitogens; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology*
D007518:Isoantibodies; D008934:Mitogens; D013954:Thyroglobulin