Somatostatin reduces the release of colony-stimulating activity (CSA) from PHA-activated mouse spleen lymphocytes.
PHA-activated lymphocytes release colony-stimulating activity (CSA) for macrophage-granulocyte precursor cells (colony forming units, CFUc) in the culture medium. Somatostatin, known to interfer with ribosomal protein synthesis, was demonstrated to reduce the release of CSA from PHA-treated mouse spleen lymphocytes.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D001854:Bone Marrow Cells; D003115:Colony-Stimulating Factors / Q000378:metabolism*; D003470:Culture Media; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013004:Somatostatin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D003115:Colony-Stimulating Factors; D003470:Culture Media; D006023:Glycoproteins; D037102:Lectins; D013004:Somatostatin; D004247:DNA; D013936:Thymidine