Suppression of B cell MIF production by T cells and soluble T cell-derived factors.
Purified populations of guinea pig B cells from nonimmunized animals may be stimualted by PPD or LPS to produce MIF. Unfractionated lymphocyte suspensions from these animals do not produce MIF under these conditions. Reconstitution of B cells with T cells abolishes their ability to generate detectable MIF. A soluble factor obtained from stimulated T cell cultures (MIFIF) is also capable of suppressing this B cell activity. Thus suppressor T cells can interfere with lymphokine production by B cells and this effect is mediated at least in part by a soluble factor. This previously undescribed capacity of T cells may provide an explanation for the fact that B cells do not appear to play a role in reactions of cell-mediated immunity in vivo.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008222:Lymphokines / Q000096:biosynthesis*; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D008934:Mitogens; D013601:T-Lymphocytes / Q000276:immunology*; D014373:Tuberculin / Q000008:administration & dosage
D000941:Antigens; D008070:Lipopolysaccharides; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D008934:Mitogens; D014373:Tuberculin