Induction of hamster T cell-specific antiserum in rabbits using hamster brain tissue.
Antiserum specific for hamster thymus-derived lymphocytes, prepared by immunizing rabbits with hamster brain tissue, was cytotoxic to hamster thymocytes greater than lymph node cells greater than spleen cells, while virtually non-reactive against bone marrow. This antiserum inhibited spleen cell response to the T cell mitogen, phytohemagglutinin, but not to lipopolysaccharide, a B cell mitogen.
D000818:Animals; D000918:Antibody Specificity; D001921:Brain / Q000276:immunology*; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D007106:Immune Sera; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*
D007106:Immune Sera; D037102:Lectins