title: Synthetic acetylenic antifungal agents.
abstract: Several monoamino bis(propynyloxy)benzenes were prepared by a Mannich reaction and tested for antifungal activity against Trichophyton schoenleini, T. mentagraphytes, T. tonsurans, Candida albicans, and Epidermophyton flocossum. In addition, the bis(propynyloxy)benzene intermediates were tested and comparisons were made with standing drugs. The intermediates were found to be the most active, although two Mannich bases possessed considerable activity.
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D002176:Candida albicans / Q000187:drug effects; D004821:Epidermophyton / Q000187:drug effects; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D008352:Mannich Bases; D010647:Phenyl Ethers