Total-body irradiation with a high-dose-rate linear accelerator for bone-marrow transplantation in aplastic anemia and neoplastic disease.
Nine children with various hematologic disorders underwent bone-marrow transplantation following total-body irradiation with 750 rads at a rate of 26 rads/min. from a 13-MeV linear accelerator in conjunction with cytotoxic drugs. This treatment was tolerated reasonably well, with acceptable side effects. Three patients were alive and well at 18, 11, and 7 months post-transplantation at the time this paper was written.
D000741:Anemia, Aplastic / Q000601:surgery*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002051:Burkitt Lymphoma / Q000601:surgery*; D006801:Humans; D007938:Leukemia / Q000601:surgery*; D011828:Radiation Chimera; D011829:Radiation Dosage; D014184:Transplantation, Homologous
D000970:Antineoplastic Agents