Effect of ionizing radiations on the life span of non-transformed human fibroblasts.
We studied in vitro the influence of ionizing radiations on the life span of non-transformed HF 19 human fibroblasts. The life span of surviving clones was found to be reduced when the cells had received two or three doses of 6 Gy separated by an interval of 15 doublings. In addition, this reduction in life span was greater when the cells were older at the time of irradiation.
D002470:Cell Survival / Q000528:radiation effects*; D002999:Clone Cells; D004307:Dose-Response Relationship, Radiation; D005333:Fetus / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008168:Lung / Q000473:pathology; D013997:Time Factors