title: Comparison of enzyme immunoassay and gas chromatography for determination of carbamazepine and ethosuximide in human serum.
abstract: Patients' sera were analyzed for carbamazepine and ethosuximide by enzyme immunoassay (x) and gas chromatography (y), and the results were compared. The correlation coefficients were: for carbamazepine, x vs. y 0.94 (n = 93); for ethosuximide, x vs. y 0.99 (n = 30). These results suggest that the two methods could be used interchangeably. Ten serum samples supplemented with carbamazepine (2.5 to 12.5 mg/liter) and ethosuximide (20.0 to 130.0 mg/liter) were analyzed by both methods. The correlation coefficients were: x vs. y 0.99 (n = 10) for carbamazepine and x vs. y 0.99 (n =10) for ethosuximide.
mesh_terms: D002220:Carbamazepine / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D005013:Ethosuximide / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques
chemical_list: D002220:Carbamazepine; D005013:Ethosuximide