Rapid murine mixed lymphocyte cultures assessed by emergence of T cell insulin receptors.
Murine T lymphocytes incubated in the mixed lymphocyte culture with allogeneic lymphocytes incompatible for the H-2 region or subregions thereof rapidly develop insulin receptors. In contrast, T cells cultured with syngeneic or H-2 and M-locus compatible cells do not develop insulin binding sites. The emergence of insulin receptors may allow rapid HLA-D typing in man.
D000818:Animals; D006680:HLA Antigens / Q000276:immunology; D066298:In Vitro Techniques; D051379:Mice / Q000276:immunology; D011972:Receptor, Insulin / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000502:physiology*
D006680:HLA Antigens; D011972:Receptor, Insulin