A case of renal transplant recipient complicated with cryptococcosis and amphotericin B induced acute tubular necrosis.
An adult renal transplant recipient was complicated with cryptococcal lung granuloma and meningitis. Treatment with the antifungal agents, 5-fluorocytocin and clotrimazole had to be discontinued due to side effects. Whereas, the intrathecal administration of amphotericin B proved effective for meningitis but intravenously it induced acute tubular necrosis to the transplanted kidney. In order to cure the persistant fungal lung granulomas in renal transplant patients early surgical excision seems to be essential.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects*; D003453:Cryptococcosis / Q000188:drug therapy / Q000209:etiology*; D006099:Granuloma / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008581:Meningitis / Q000188:drug therapy / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D000666:Amphotericin B