Arsenate-resistant alkaline phosphatase-constitutive mutants of Escherichia coli.
When arsenate-resistant mutants are selected approximately 50 per cent of them are also consitutive for the synthesis of alkaline phosphatase and the Pi-binding protein. Some of these mutants are linked to ilv (phoS- or phoT-), other are linked to proC (phoR-). One of the mutant strains linked to ilv lost the Pi-binding protein (the phoS gene product). Resistance to arsenate, constitutivty for alkaline phosphatase synthesis and loss of the Pi-binding protein occurred pleiotropically by the same phoS- mutation.
D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D001149:Arsenates / Q000494:pharmacology*; D001151:Arsenic / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis; D002874:Chromosome Mapping; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D008040:Genetic Linkage; D007122:Immunoelectrophoresis; D009154:Mutation; D010710:Phosphates / Q000378:metabolism; D011485:Protein Binding
D001149:Arsenates; D001426:Bacterial Proteins; D002352:Carrier Proteins; D010710:Phosphates; D000469:Alkaline Phosphatase; D001151:Arsenic