title: [Timolol and acetazolamide in the treatment of increased intraocular pressure (author's transl)].
abstract: Twenty-four patients with open-angle glaucoma were tested to see if, and to what extent, timolol and acetazolamide produced a supplementary reduction of intraocular pressure. Twelve patients were treated with timolol eye drops, 0.5% b.d over a period of one week and then received one dose i.v. acetazolamide 250 mg which produced a statistically significant drop in intraocular pressure. Twelve patients with open-angle glaucoma who had been treated with acetazolamide 500 mg t.d.s. orally over a period of one week, received one drop of timolol 0.25% which produced a statistically significant additional effect. These results are discussed on the basis of the mode of action of the applied medications.
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D011412:Propanolamines; D013999:Timolol; D000086:Acetazolamide
vernacular_title: Timolol und Acetazolamid bei der Behandlung des erhöhten intraocularen Druckes.