Age differences in the effect of glucagon on the metabolism of glucose precursors in perfused rat liver.
The effect of glucagon on the uptake and incorporation of 14C-pyruvate and 14C-alanin into glucose was studied in perfused liver of young (aged 10 days) and adult (aged 120 days) male rats. It was found that the processes studied were significantly higher (P less than 0.005) in young animals, the difference being still more remarkable after the injection of glucagon (10 microgram kg-1) to the animals (liver donors) one hour before the dissection of liver.
D000375:Aging; D000409:Alanine / Q000378:metabolism*; D000818:Animals; D005934:Glucagon / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats
D011773:Pyruvates; D005934:Glucagon; D000409:Alanine