Kallman's syndrome: effect of repeated stimulation of pituitary-gonadal axis with LH-RH.
The relative roles of the central nervous system and pituitary in the pathogenesis of olfactory gonadal dysplasia has been the subject of much speculation. Repeated stimulation of the pituitary gonadal axis with LH-RH provoked a moderate release of gonadotropins, insufficient however, to stimulate gonadal incretory function. This study supports the evidence that a hypothalamic defect is the basis for Kallman's syndrome.
D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D010053:Ovary / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects*; D013577:Syndrome; D013737:Testis / Q000187:drug effects
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone