Depressed non-specific lymphocyte reactivity in psoriasis.
T-lymphocyte number and functions were studied in 24 patients with psoriasis guttata as compared to healthy controls. A decrease was found of the in vitro ability to synthetize DNA in response to stimulation with phytohemagglutinin (PHA), concanavalin A, poke weed mitogen and PPD, which was statistically significant for PHA. The percentage and absolute numbers of both T and B peripheral blood lymphocytes were not altered.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002452:Cell Count; D003208:Concanavalin A; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D008934:Mitogens; D010835:Phytohemagglutinins; D011565:Psoriasis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014373:Tuberculin
D008934:Mitogens; D010835:Phytohemagglutinins; D014373:Tuberculin; D003208:Concanavalin A