[Effect of somatotropic hormone on autoimmune responses induced in mice of different genotypes by syngenous heated erythrocytes].
A single administration of 1 X 10(9) heated erythrocytes to C57BL and BALB/c mice caused on the 13th day the appearance of antierythrocytic autoantibodies, an increase in the weight of the lymphoid organs, and lymphoreticular hyperplasia. These changes were more pronounced in BALB/c mice. During the development of autoimmune reactions the changes in the number of E- and EAC-rosette-forming cells in the thymus and spleen and in the immune response to the sheep erythrocyte immunization and E. coli endotoxin were revealed; distinct strain differences were observed. Daily somatotropic hormone administration (5 mg/kg of body weight) for 10 days decreased the degree of the autoimmune reactions development in mice of both strains. Its action was more expressed in BALB/c mice.
D000818:Animals; D001327:Autoimmune Diseases / Q000517:prevention & control*; D004731:Endotoxins; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000627:therapeutic use*; D007104:Immune Adherence Reaction; D007166:Immunosuppressive Agents; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009929:Organ Size; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014184:Transplantation, Homologous
D004731:Endotoxins; D007166:Immunosuppressive Agents; D013007:Growth Hormone-Releasing Hormone
Vliianie somatotropnogo gormona na autoimmunye reaktsii, indutsirovannye u mysheĭ raznykh genotipov singennymi progretymi éritrotsitami