The use of intra-arterial lidocaine to control pain due to aortofemoral arteriography.
Intra-arterial lidocaine has been utilized to decrease pain by administration prior to contrast material injections during aortofemoral arteriography in over 600 patients. Because this observation was uncontrolled, a double-blind study was performed in 15 patients comparing the effectiveness of intra-arterial lidocaine and saline in  the control of pain from contrast material injections (methylglucamine iothalamate) in pelvic and peripheral arteriography. Two per cent lidocaine was compared with 1% lidocaine in the same manner in an additional 10 patients. Peripheral vein blood samples were obtained in 4 patients to measure the plasma concentration of lidocaine. Intra-arterial lidocaine is safe and effective in reducing pain from intra-arterial contrast agent injections.
D000792:Angiography; D001011:Aorta; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000008:administration & dosage*; D004311:Double-Blind Method; D005263:Femoral Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D007482:Iothalamate Meglumine / Q000008:administration & dosage; D008012:Lidocaine / Q000008:administration & dosage* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy*
D003287:Contrast Media; D008012:Lidocaine; D007482:Iothalamate Meglumine