[Methods of determination of toxicity of pertussis vaccine. 1. Change in the weight of the thymus gland and the spleen in mice after administration of pertussis vaccine].
Experiments were conducted on mice, strain NIH, line HSFS/N, immunized with pertussis vaccine. Determination of thymocyte pool proved to be a more sensitive method of detection of the stress effect of the vaccine than determination of the thymus weight. The test can be used for the elaboration of the method of assessment of the toxicity of pertussis preparations.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D006984:Hypertrophy; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology*; D051379:Mice; D009929:Organ Size; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity*; D013154:Spleen / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*
D010567:Pertussis Vaccine
K voprosu o metodakh opredeleniia toksichnosti kokliushnykh vaktsin. Soobshchenie 1. Izmenenie vesa timusa i selezenki u myshei posle vvedeniia kokliushnoĭ vaktsiny.