Occurrence of disseminated intravascular coagulation (DIC) in obstructive jaundice and its relation to biliary tract infection.
Coagulation studies were done on 78 consecutive cases of obstructive jaundice with or without biliary tract infection. Among 26 cases with biliary tract infection 20 cases showed no bleeding tendency but remarkable hypercoagulability with decreased fibrinolytic activity. Other six cases developed diffuse bleeding tendency in addition to the signs of hypotension and multiorgan dysfunction such as oliguria, respiratory distress and mental confusion. Most showed marked coagulation defects characterized by thrombocytopenia, decreased fibrinogen, antithrombin III and plasminogen levels and narrowing of maximal amplitude in thrombelastogram as well as the increase of fibrin degradation products and positive soluble fibrin monomer complexes. All except one died and three cases were autopsied. In two cases postmortem examination revealed multiple fibrin thrombi in lungs and other organs. A cause of the development of bleeding tendency in obstructive jaundice presently observed may likely to be due to the occurrence of disseminated intravascular coagulation (DIC), i.e. hypercoagulability caused by the biliary tract infection is responsible.
D000328:Adult; D000368:Aged; D000991:Antithrombins / Q000032:analysis; D001424:Bacterial Infections / Q000097:blood / Q000150:complications* / Q000382:microbiology; D001652:Bile Ducts / Q000382:microbiology; D001660:Biliary Tract Diseases / Q000097:blood / Q000150:complications* / Q000382:microbiology; D002761:Cholangitis / Q000150:complications; D002779:Cholestasis / Q000097:blood / Q000150:complications*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D007709:Klebsiella / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000991:Antithrombins; D005338:Fibrin Fibrinogen Degradation Products; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen