Further characterization of the human inducer T cell subset defined by monoclonal antibody.
Evidence is presented that the OKTA+ T cell subset in man, defined by a monoclonal hybridoma antibody, provides help for B lymphocyte differentiation in a PWM driven system. Both B cell proliferation and intracytoplasmic immunoglobulin synthesis are facilitated by OKT4+ and not by OKT4- T cells. Given earlier studies demonstrating that OKT4+ T cells were necessary for generation of T cytotoxic cells and the present study that OKT+ T cells are necessary for the differentiation of B cells, it would appear that the OKT+ population is the major human T helper (inducer) subset.
D000818:Animals; D000906:Antibodies; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D002999:Clone Cells / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D006041:Goats; D006801:Humans; D051379:Mice; D010950:Plasma Cells / Q000166:cytology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011947:Receptors, Antigen, B-Cell; D013601:T-Lymphocytes / Q000145:classification*
D000906:Antibodies; D011043:Pokeweed Mitogens; D011947:Receptors, Antigen, B-Cell