Teratology study in mice subjected to inhalation of diethylhydroxylamine, nitroethane, and diethylamine hydrogen sulfite.
Pregnant female mice were exposed from Days 6 to 17 of pregnancy to 8.9 +/- 2.0 ppm of diethylhydroxylamine and 14.3 +/- 2.0 ppm of nitroethane. Exposures were for 8.25 +/- 2.25 hours/day including weekends. The mice were also exposed continuously for 24 hours a day to the vapor of diethylamine hydrogen sulfite. The exposure produced no effect on the dams compared to the control group. There was no evidence of compound-induced terata, variation in sex ratio, embryotoxicity, or inhibition of fetal growth and development.
D000280:Administration, Inhalation; D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D004048:Diethylamines / Q000633:toxicity*; D004980:Ethane / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006898:Hydroxylamines / Q000633:toxicity*; D008297:Male; D051379:Mice; D009595:Nitroparaffins / Q000633:toxicity*; D011247:Pregnancy; D012744:Sex Ratio; D013447:Sulfites / Q000633:toxicity*; D013723:Teratogens
D000473:Alkanes; D004048:Diethylamines; D006898:Hydroxylamines; D009595:Nitroparaffins; D013447:Sulfites; D013723:Teratogens; C033314:N,N-diethylhydroxylamine; C014705:nitroethane; D004980:Ethane; C042345:hydrogen sulfite