Cerebrovascular response to intracarotid infusion of 5-hydroxytryptophan and L-DOPA  in cats.
Intracarotid administration of 5-hydroxytryptophan (10 mg/kg) results in a slight vasoconstriction of cerebral vessels. L-DOPA (20 mg/kg) administered by the same route enhances cerebral blood flow. The effect on cerebral blood flow of L-DOPA (20 mg/kg) following intracarotid 5-hydroxytryptophan (10 mg/kg) administration shows a potentiation of cerebral blood flow response in non-pretreated as well as in nialamide- and reserpine-pretreated cats.
D006916:5-Hydroxytryptophan / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002339:Carotid Arteries; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004562:Electrocardiography; D005260:Female; D007269:Injections, Intra-Arterial; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D013997:Time Factors
D007980:Levodopa; D006916:5-Hydroxytryptophan