Identification of TL+ thymocytes with different Lyt phenotypes.
The surface antigenic phenotype of BALB/c thymocytes has been analyzed by sequential cytotoxic treatment with Lyt-1.2, Lyt-2.2 and TL.2 antisera plus complement. Two new minor subpopulations with TL+Lyt-1+2- and TL+Lyt-1-2+ phenotypes have been identified providing direct evidence for the heterogeneity of the Lyt phenotype among the TL-positive supopulation of thymocytes. This finding suggests that differentiation pathways of Lyt subsets of T cells are more complex than originally proposed and that commitment to separate lines of differentiation may occur already at the level of immature, cortical thymocytes.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002454:Cell Differentiation; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D007106:Immune Sera; D007519:Isoantigens; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D007106:Immune Sera; D007519:Isoantigens; D003165:Complement System Proteins