[Effect of clomiphene on the restoration of ovulation in androgen-sterile rats].
In the androgen-sterile rats given 10-250 mug of testosterone-propionate there was observed at the early postnatal period a reduction in the LH-RP level in the hypothalamus, of the LH in the hypophysis and the blood, of the weight of the ovaries and of the corporal luteum count in them, as well as an increase in the dopamine level in the anterior portion of the hypothalamus. Klomiphen administration for 5 days in a dose of 20 mug led to the normalization of these indices and to the appearance of ovulation, but failed to restore the capacity to pregnancy. Prolonged klomiphen administration (20 mug every 3 days for a period of 1 month) also failed to restore this capacity.
D000818:Animals; D000858:Anovulation / Q000188:drug therapy* / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism; D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use*; D004967:Estrogens / Q000097:blood; D004971:Estrus; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007247:Infertility, Female / Q000139:chemically induced; D007986:Luteinizing Hormone / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D013739:Testosterone
D002395:Catecholamines; D004967:Estrogens; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D011374:Progesterone; D007986:Luteinizing Hormone
Vliianie klomifena na vosstanovlenie ovuliatsii u androgensteril'nykh krys