Refractory Pneumocystis carinii infection in chronic granulomatous disease: successful treatment with granulocytes.
Pneumocystis carinii pneumonia developed in an 11-year-old girl with chronic granulomatous disease who had normal cellular and humoral immunity. The patient remained febrile during treatment with sulfamethoxazole-trimethoprim and pentamidine but became afebrile when treated with a series of 12 granulocyte transfusions combined with sulfamethoxazole-trimethoprim. In addition to documenting P carinii infection in chronic granulomatous disease our findings suggest that granulocyte transfusions may be of value in the treatment of severe infections in chronic granulomatous disease.
D001803:Blood Transfusion; D002648:Child; D004338:Drug Combinations; D005260:Female; D006098:Granulocytes / Q000637:transplantation*; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole