title: [Membrane permeability and antibiotic resistance in bacteria].
abstract: The resistance of mainly gram-negative bacteria against antibiotics is discussed with respect to new discoveries on the permeability barrier of the outer membrane. Proteins originally characterized as virus receptors have been found to be involved in the translocation of certain substrates across the membrane. Antibiotics can reach their target by the same "pores".
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000648:ultrastructure; D001426:Bacterial Proteins / Q000502:physiology; D001435:Bacteriophages / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D002463:Cell Membrane Permeability / Q000187:drug effects; D002473:Cell Wall / Q000502:physiology; D004058:Diffusion; D004352:Drug Resistance, Microbial; D007501:Iron / Q000378:metabolism; D008070:Lipopolysaccharides / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009154:Mutation; D010957:Plasmids; D011485:Protein Binding; D011955:Receptors, Drug / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D011955:Receptors, Drug; D007501:Iron
vernacular_title: Membranpermeation und Antibiotika-Resistenz bei Bakterien