[The effect of bencyclane, flunarizine and naftidrofuryl on a calorically induced long time nystagmus (author's transl)].
The method of a calorically induced long time stimulation is shown. Appr. 15 minutes after begin fo stimulation a nystagmus plateau can be observed. We used this plateau to demonstrate the effects of three cerebral vasoactive drugs--Bencyclane, Flunarizine and Naftidrofuryl-Hydrogenoxalate in a randomized double blind study. All of them depressed the nystagmus significantly. Naftidrofuryl by 38.4 +/- 4.6%, Flunarizine by 31 +/- 4.5% and Bencyclane by 25.1 +/- 3.8%. The depressing mechanism of Flunarizine is partly due to sedation.
D000328:Adult; D001537:Bencyclane / Q000494:pharmacology*; D002150:Caloric Tests; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology*; D003508:Cycloheptanes / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D009257:Nafronyl / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D010919:Placebos; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D003508:Cycloheptanes; D005663:Furans; D010879:Piperazines; D010919:Placebos; D002936:Cinnarizine; D009257:Nafronyl; D001537:Bencyclane
Die Wirkung von Bencyclan, Flunarizin und Naftidrofuryl auf den Nystagmus eines kalorischen Dauerreizes.