Acquired aplastic anemia in adults. IV. Histological and CFU studies in transplanted and non-transplanted patients.
A follow-up study of 10 patients suffering from acquired aplastic anaemia, comprising methocrylate-embedded bone marrow biopsies and CFU cultures, is presented. The haematopoietic recovery patterns and changes in the inflammatory infiltration after permanent engraftment could be distinguished from those in non-transplanted patients. After anti-thymocyte globulin treatment followed by allogeneic bone marrow infusion, the recovery pattern resembled that in non-transplanted patients. The persistently low colony-forming capacity in some patients could be explained by the existence of lymphoid inhibitory cells, which suggests an immunologic auto-destructive mechanism.
D000328:Adult; D000741:Anemia, Aplastic / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D000888:Antibodies, Anti-Idiotypic; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002455:Cell Division; D002478:Cells, Cultured; D002999:Clone Cells; D003470:Culture Media; D005500:Follow-Up Studies; D006410:Hematopoiesis; D006801:Humans; D007104:Immune Adherence Reaction; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D003470:Culture Media