Changes in renal inactivation of angiotensin II in rats with hereditary spontaneous hypertension.
The inactivation of the pressor effect of angiotensin II by the renal vascular bed is less in spontaneously hypertensive rats than in normal rats. This phenomenon, which is observed only in adult animals but not in young ones, may be due to a slowing in the functional maturation of the kidney tissue.
D000367:Age Factors; D000804:Angiotensin II / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D006977:Hypertension, Renal / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012737:Sex Factors
D000804:Angiotensin II; D009638:Norepinephrine