Amphotericin B methyl ester: evaluation for intravitreous use in experimental fungal endophthalmitis.
Amphotericin B methyl ester, a water-soluble derivative of amphotericin B, is an experimental antifungal agent. Intravitreous injection of 5 and 10 micrograms of amphotericin B methyl ester in the normal rabbit eye does not cause toxic changes that can be detected clinically, microscopically, or by electroretinography. A single intravitreous injection of 5 micrograms was effective in reversing the course of exogenous Candida fungal endophthalmitis when administered within five days after inoculation of the infecting organism.
D000666:Amphotericin B / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy; D004195:Disease Models, Animal; D009877:Endophthalmitis / Q000188:drug therapy* / Q000473:pathology; D007267:Injections; D009181:Mycoses / Q000188:drug therapy*; D011817:Rabbits; D014822:Vitreous Body
D000666:Amphotericin B