Bradykininase and protease inhibitors in seminal plasma of fertile and infertile men.
The level of protease acrosin in the seminal plasma of oligozoospermic men was significantly higher than that of normozoospermic men. The amount of bradykininase in the seminal plasma was very high in both normozoospermic and oligozoospermic patients. When the acrosin and kininase content was referred to one million spermatozoa, seminal plasma kininase was significantly enhanced in oligozoospermic men, while the acrosin activity was similar in normozoospermic fertile men and infertile men. Human seminal plasma inhibitor I (HUSI I) increased along with sperm count. Human seminal plasma inhibitor II (HUSI II) showed no change. The motility of spermatozoa was depressed in oligozoospermic patients.
D000176:Acrosin / Q000032:analysis; D007611:Aprotinin / Q000032:analysis; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000032:analysis; D006801:Humans; D007248:Infertility, Male / Q000201:enzymology*; D008297:Male; D009845:Oligospermia / Q000201:enzymology; D010447:Peptide Hydrolases / Q000032:analysis*; D012661:Semen / Q000201:enzymology*; D013075:Sperm Capacitation; D013076:Sperm Count; D013078:Sperm Immobilizing Agents / Q000494:pharmacology
D004791:Enzyme Inhibitors; D013078:Sperm Immobilizing Agents; D007611:Aprotinin; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D000176:Acrosin; D001920:Bradykinin