Para-aminobenzoate inhibition of precipitation of urine salts.
Lehmann's observation that potassium para-aminobenzoate has a "salt precipitating preventive effect" in urine was confirmed in rats. This effect persisted during the 3-week period of drug administration. There was associated no significant change in urine volume, osmolality, or per cent solids. Since there is a large clinical experience in the chronic use of even larger doses, it would appear quite feasible to determine the clinical usefulness of this property of para-aminobenzoate in the prevention of recurrent renal calculi.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology* / Q000652:urine; D062365:Aminobenzoates / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002621:Chemistry; D004573:Electrolytes / Q000652:urine; D005260:Female; D009994:Osmolar Concentration; D010710:Phosphates / Q000652:urine; D051381:Rats; D012492:Salts / Q000652:urine*; D013997:Time Factors
D062365:Aminobenzoates; D004573:Electrolytes; D010710:Phosphates; D012492:Salts; D010129:4-Aminobenzoic Acid