VM 26 and VP 16-213: a comparative analysis.
VM 26 and VP 16-213 are epipodophyllotoxin analogs. This paper presents a comparative analysis of their experimental and clinical features but fails to disclose any significant difference between these drugs. Similar studies with other classes of compounds might help to define some rationale for the development of analogous cytotoxic agents.
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy; D004341:Drug Evaluation; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013713:Teniposide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D005047:Etoposide; D013713:Teniposide; D011034:Podophyllotoxin