Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus.
Anti-Lyb-5.1 serum contains antibodies against two different B cell surface antigenic determinants, Lyb-5.1 and Lyb-7.1, which are defined in cytotoxicity and functional tests, respectively. The antibody against Lyb-7.1 is identified by its ability to specifically inhibit in vitro primary antibody responses to TNP-Ficoll. Anti-Lyb-5.1 serum can be made monospecific for anti-Lyb-7.1 activity by absorption with spleen cells from AL/N mice which have been typed as Lyb-5.1+, Lyb-7.1-. Lyb-5.1 and Lyb-7.1 are each under control of one or one set of closely linked genes. The loci specifying Lyb-5.1 and Lby-7.1 are not linked to each other nor to M1s and H-2 loci. However, the gene controlling the expression of Lyb-7.1 is linked to the genes coding for the constant region of immunoglobulin heavy chains.
D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001667:Binding, Competitive; D002874:Chromosome Mapping; D003602:Cytotoxicity, Immunologic; D005260:Female; D005796:Genes; D005815:Genetic Code; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000276:immunology; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007074:Immunoglobulin G; D007136:Immunoglobulins / Q000235:genetics*; D007519:Isoantigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA
D000961:Antilymphocyte Serum; D006183:H-2 Antigens; D007127:Immunoglobulin Constant Regions; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007519:Isoantigens