[Studies on the question of a possible autoregulation of insulin secretion (author's transl)].
In eight normal weight healthy volunteers it was proved by C-peptide assay whether high concentrations of insulin in serum would suppress the secretion of insulin in an autoregulative manner. Insulin combined with glucose, therefore was given intravenously as a single bolus injection as well as an infusion over a period of two hours. Moreover it was proved whether high levels of insulin would suppress the reactivity of the B-cell to sulphonylurea administration. It was demonstrated that the secretion of the B-cell is regulated only by the concentration of the blood sugar, but not by the level of serum insulin. Likewise the stimulation of the B-cell by sulphonyl-urea administration is not suppressed by high concentrations of insulin.
D001786:Blood Glucose; D002096:C-Peptide / Q000097:blood; D003864:Depression, Chemical; D004338:Drug Combinations; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000494:pharmacology
D001786:Blood Glucose; D002096:C-Peptide; D004338:Drug Combinations; D007328:Insulin; D013453:Sulfonylurea Compounds; D005947:Glucose
Untersuchungen zur Frage einer Autoregulation der Insulinsekretion.