title: The unity of genes in the major histocompatibility complex.
abstract: The major histocompatibility complex (MHC) of the mouse can be genetically divided into several regions specialized to performing specific functions. Thus the class I regions (K and D) code for antigens that activate effector (killer) T cells, class II region (I) for antigens causing T-cell proliferation, and class III regions (s) for complement components. A strong case is made for the theory that the division of labor within the MHC is not absolute. Evidence is presented that class I antigens can sometimes cause as strong T-cell proliferation as class II antigens; that class II antigens can generate effector T cells; and that class I antigens may be involved in the immune response to some antigens. The fact that different regions can perform similar functions argues for the unity of the MHC genes.
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics; D002455:Cell Division; D003165:Complement System Proteins / Q000235:genetics; D005815:Genetic Code; D006649:Histocompatibility Antigens; D007125:Immunogenetics; D051379:Mice / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens; D006649:Histocompatibility Antigens; D003165:Complement System Proteins