Aspirin and gastrointestional bleeding. Interest of plasma salicylate determination.
From history-taking and from analysis of plasma salicylate levels it is shown that a link exists between aspirin and gastrointestinal bleeding in 68% of cases. Salicylate levels alone indicate that aspirin has been taken in 22% of cases. Plasma salicylate measurement and endoscopy allow a better understanding of haemorrhagic lesions due to aspirin. Aspirin is responsible especially for haemorrhage from ulcers and acute gastritis or duodenitis. Aspirin is seen to be dangerous in a moderate number of susceptible individuals: those with peptic ulcer constitution or cirrhosis.
D001241:Aspirin / Q000009:adverse effects*; D004378:Duodenal Diseases / Q000139:chemically induced; D004751:Enteritis / Q000139:chemically induced; D005756:Gastritis / Q000139:chemically induced; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced; D012459:Salicylates / Q000097:blood
D012459:Salicylates; D001241:Aspirin