title: T-cell immunity to malaria in the B-cell deficient mouse.
abstract: Some B-cell deficient mice drug-rescued with clindamycin HCl from otherwise lethal infections with Plasmodium yoelii resisted subsequent challenge with the same parasite despite the fact that they lacked detectable antibody to plasmodia. Parasitemias remained patent but at low levels (less than or equal to 5%) in these mice for prolonged periods of time, suggesting that some T-cell function independent of antibody formation can in part mediate immunity to malaria.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000276:immunology*; D002981:Clindamycin / Q000627:therapeutic use; D007110:Immunity, Active / Q000187:drug effects; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D008288:Malaria / Q000188:drug therapy / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010961:Plasmodium / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M; D002981:Clindamycin