Action of the N-trifluoroacetyl analogue of D-chloramphenicol.
The N-trifluoroacetyl analogue of chloramphenicol was found to inhibit the growth of Escherichia coli less than chloramphenicol, rather than more as previously reported by others. It also inhibits protein synthesis by E. coli and rat liver mitochondria less.
D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis; D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007739:L Cells / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D051381:Rats
D001426:Bacterial Proteins; D002701:Chloramphenicol; D009247:NADH, NADPH Oxidoreductases