[The oral administration of N-benzoyl-L-tyrosyl-paraaminobenzoic acid (PFT) in the assessment of exocrine pancreatic function and its value within the diagnostic approach to pancreatic disease (author's transl)].
Exocrine pancreatic function was determined by the oral administration of N-benzoyl-L-tyrosyl-PABA in 343 persons, including controls, patients with diseases of the pancreas, and patients with non-pancreatic disease. The results revealed a sensitivity of 85% in chronic pancreatitis and of 78% in carcinoma of the pancreas. The specificity of the PFT amounted to 92%. No toxic side effects were noted. The PFT is likely to be a useful screening procedure for pancreatic disease.
D010129:4-Aminobenzoic Acid; D062365:Aminobenzoates; D001660:Biliary Tract Diseases / Q000175:diagnosis; D005069:Evaluation Studies as Topic; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis; D008403:Mass Screening; D010179:Pancreas / Q000503:physiopathology*; D010182:Pancreatic Diseases / Q000175:diagnosis*
D062365:Aminobenzoates; D010129:4-Aminobenzoic Acid
Stellenwert des oralen Pankreasfunktionstests mit N-Benzoyl-L-Tyrosyl-Paraaminobenzoesäure (PABA-Test) in der exokrinen Pankreasfunktionsdiagnostik.