[Inactivation of the colony forming cells in bone marrow by allogenic T-lymphocytes].
Bone marrow cells together with allogeneic cortisone-resistant thymocytes or the lymph node cells of intact mice treated with antilymphocytic T or O-antisera were transplanted to the lethally irradiated mice. The antisera eliminated the capacity of T lymphocytes to inactivate allogeneic stem cells. Cortisone-resistant thymocytes displayed a strong inactivating action. The principal role in the processes of inactivation of genetically foreign stem cells was played by T lymphocytes. B lymphocytes possessed no properties of killer cells. The presence of B lymphocytes in the population of killer cells apparently failed to serve as a determinant one for the development of inactivation processes.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001853:Bone Marrow / Q000276:immunology*; D002999:Clone Cells; D003165:Complement System Proteins; D003348:Cortisone / Q000494:pharmacology; D004351:Drug Resistance; D006824:Hybridization, Genetic; D007165:Immunosuppression Therapy; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000637:transplantation*; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D003165:Complement System Proteins; D003348:Cortisone
Inaktivatsiia kolonieobrazuiushcheĭ sposobnosti kletok kostnogo mozga allogennymi T-limfotsitami.