A possible role for 5-hydroxytryptamine as a mediator for calcitonin actions on the gastrointestinal tract and pancreas in rats.
Administration of pig calcitonin (10 M.R.C. units/kg body wt.) produced an immediate decrease in 5-hydroxytryptamine content in the antrum-duodenum region and ileum. In contrast, the hormone treatment rapidly increased the concentration of 5-hydroxytryptamine in the blood and pancreas. Serum immunoreactive gastrin did not change over a period of 3h after calcitonin administration. The results suggest that the release of 5-hydroxytryptamine probably mediates calcitonin actions on the gastrointestinal tract and pancreas.
D006916:5-Hydroxytryptophan / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D005755:Gastrins; D002116:Calcitonin; D006916:5-Hydroxytryptophan