[Effect of testosterone propionate on the lymphoid system and antibody-producing capacity in golden hamsters].
The effect of testosterone-propionate on the lymphoid tissue and humoral immunological response to SRBC was studied in 224 golden hamsters of both sex. The hormone was injected intramuscularly in a dose of 1 and 5 mg every other day (a total of 10 injections). Testosterone caused thymus atrophy, hypoplasia of the spleen, reduction of the absolute B lymphocyte count in the bone marrow, forming cell count and a fall of the serum hemolysin titre in the immunized animals. The detected changes were found to be more pronounced in female animals.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001854:Bone Marrow Cells; D002452:Cell Count; D006224:Cricetinae; D003864:Depression, Chemical; D005260:Female; D008198:Lymph Nodes / Q000166:cytology*; D008297:Male; D008647:Mesocricetus; D013154:Spleen / Q000166:cytology*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone
Vliianie testosterona propionata na limfoidnuiu sistemu i antiteloobrazuiushchuiu sposobnost' u zolotistykh khomiakov.