Immunity to chemically induced rat sarcomas: study of the specificity of cytotoxic cells.
Spleen cells from WAG rats bearing methylcholanthrene-induced sarcomas were cytotoxic for homologous tumour cells and for some cell lines derived from other syngeneic tumours. Each tumour induced its own pattern of cross-reactive cytotoxicity. This cross-reactivity was not apparent by in vivo rejection tests. In tumour-bearing rats, specific cytotoxic cells could not be separated from cross-reactive cytotoxic cells. The effector cells did not adhere to plastic surface, they were retained neither on nylon wool nor on anti-Ig columns and were devoid of Fc receptors. After tumour excision the cells displaying specific cytotoxicity had the same properties and thus were probably T cells. In contrast, the cells exhibiting cross-reactive cytotoxicity were lost after passage through a nylon wool column or after the removal of Fc-receptor-bearing lymphocytes. These findings suggest that cross-reactivity could result from antibody-dependent cell-mediate cytotoxicity directed against shared antigens.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D005260:Female; D007700:Kinetics; D008748:Methylcholanthrene; D051381:Rats; D011919:Rats, Inbred Strains; D011961:Receptors, Fc / Q000276:immunology; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D011961:Receptors, Fc; D008748:Methylcholanthrene