[The pathogenesis of psoriasis : realities and hypotheses (author's transl)].
Our pathogenic pattern, may be summarised in 7 propositions : - psoriasis is a proliferative disease of the epidermis. - the increased mitotic activity is related to imbalance of cyclic nucleotides and of prostaglandins. - this imbalance may be explained by abnormalities of the membranes of the keratinocytes. - this alteration in cell membranes results from immunological phenomena located in psoriatic epidermis. - the disturbance of immunity with production of auto-antibodies may be related to a deficiency in a sub-population of thymus-dependent lymphocytes. - this cyclic deficiency could be due to a viral agent whose penetration and persistence in the body would be dependent upon multiple genetic factors. - numerous external factors may act upon the various steps of this pathogenic chain, to worsen a pre-existent imbalance and precipitate the development of the lesions.
D000974:Antibodies, Antinuclear; D001323:Autoantibodies / Q000096:biosynthesis; D002462:Cell Membrane; D006649:Histocompatibility Antigens; D006801:Humans; D007074:Immunoglobulin G; D008938:Mitosis; D011453:Prostaglandins / Q000378:metabolism; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology; D012265:Ribonucleotides / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006649:Histocompatibility Antigens; D007074:Immunoglobulin G; D011453:Prostaglandins; D012265:Ribonucleotides
Pathogénie du psoriasis : réalités et hypothèses.