title: Ultrastructure of the gut neurotensin cell.
abstract: In mammals, neurotensin cells occur scattered in the epithelium of the jejunum-ileum. In chicken, neurotensin cells are abundant in the region of the gizzard-duodenal junction (antrum) where they occur intermingled with numerous somatostatin and gastrin cells. The neurotensin cells in chicken, dog and man were identified at the electron microscopic level by immunocytochemistry, using the consecutive semithin/ultrathin section technique. They contain numerous electron dense cytoplasmic granules, pre-dominantly in the basal portion of the cell. It was shown that these granules are the storage site for neurotensin. The neurotensin granules are round, highly electron dense and of about the same size in the different species examined (mean diameter 260--290 nm). In dog and man the granules have a tightly applied surrounding membrane while in the chicken a relatively electron lucent zone separates the electron dense core from the granule membrane. The ultrastructure of the neurotensin granules in chicken is somewhat reminiscent of that of the gastrin granules. The mean diameter of the gastrin granules in chicken antrum is 230 nm; for the somatostatin granules the mean diameter is 305 nm.
mesh_terms: D000818:Animals; D002645:Chickens; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004285:Dogs; D005755:Gastrins / Q000032:analysis; D006801:Humans; D007082:Ileum / Q000032:analysis / Q000648:ultrastructure*; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000032:analysis / Q000648:ultrastructure*; D007583:Jejunum / Q000032:analysis / Q000648:ultrastructure*; D009496:Neurotensin / Q000032:analysis*; D013004:Somatostatin / Q000032:analysis; D013278:Stomach, Avian / Q000032:analysis / Q000648:ultrastructure*
chemical_list: D005755:Gastrins; D009496:Neurotensin; D013004:Somatostatin