Kinetics of antibody response in unprimed recipients after transfer of immune lymphocytes.
Spleen cells from mice immunized with SRBC were transferred, at various times after immunization, to non-irradiated and lethally irradiated syngeneic recipients. The PFC kinetics and anti-SRBC antibody titres were followed in various groups of mice. Similar results were obtained both in non-irradiated and lethally irradiated recipients, showing that after the transfer: a) PFC proliferation was blocked, b) PFC blocking was unrelated to their maturation stage, c) resting PFC were still able to synthesize antibodies, d) blocking activity was radio-resistant.
D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D001402:B-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D001803:Blood Transfusion; D004912:Erythrocytes / Q000276:immunology; D006386:Hemagglutination Tests; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D012756:Sheep