[Lymphotoxin production by human lymphocytes. III. The action of adenovirus antigen].
In lymphocyte cultures (LC) from 5 immune donors blast transformation occurred as a result of the stimulting action of adenovirus antigen; the supernatants obtained from these cultures produced a cytotoxic effect on L cells, thus suggesting the presence of lymphotoxin (LT). No blast transformation and no LT production were detected in nonstimulated LC used for control, as well as in LC from 9 nonimmune donors. LT production was shown to depend on the time elapsed after recovery from acute adenovirus infection. LT production was found to be most intensive during the first 2 months after recovery.
D000208:Acute Disease; D000258:Adenovirus Infections, Human / Q000276:immunology; D000260:Adenoviruses, Human / Q000276:immunology*; D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D003602:Cytotoxicity, Immunologic; D006801:Humans; D066298:In Vitro Techniques; D007739:L Cells / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000096:biosynthesis*; D051379:Mice; D014069:Tonsillitis / Q000276:immunology
D000956:Antigens, Viral; D008233:Lymphotoxin-alpha
Prosuktsiia limfotoksina limfotsitami cheloveka. Soobshchenie III. Deĭstvie adenovirusnogo antigena.