The effect of cholestyramine on serum lipids and platelet aggregation of hypercholesterolemic children (type II A) while on high linoleic acid diet.
25 children with familial hypercholesterolemia (type II A) were treated with cholestyramine or placebo in a cross over study during 2 periods of each 10 weeks. The medication was added to a high linoleic acid diet, which had been started at least 1 year earlier. Serum lipids and platelet aggregation were investigated at the end of the 2 periods. On cholestyramine, serum cholesterol levels decreased significantly, whereas the linoleate and oleate content of cholesterylesters and serum triglycerides did not change systematically. Platelet aggregation time, measured with a filtragometer, did not systematically change either.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D008041:Linoleic Acids / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D010919:Placebos; D010974:Platelet Aggregation / Q000187:drug effects*; D014280:Triglycerides / Q000097:blood
D008041:Linoleic Acids; D008055:Lipids; D010919:Placebos; D014280:Triglycerides; D002792:Cholestyramine Resin; D002784:Cholesterol