Choriocarcinoma in mother and child, identified by immunoenzyme histochemistry.
A case of metastic choriocarcinoma after term pregnancy, with tumor localization in the kidney of a hydropic stillborn infant, is presented. The primary tumor was found in a scraping four weeks after delivery. The identity and nature of the malignant growth in mother and child were substantiated by identical immunohistochemical patterns for gonadotropin activity. Because of a positive Kleihauer test it was assumed that massive feto-maternal transfusion had caused the hydrops and intrauterine death. Now, four and a half months after starting methotrexate therapy, the mother seems to be free of tumor. Plasma human chorionic gonadotropin titers have decreased to normal.
D000328:Adult; D002822:Choriocarcinoma / Q000175:diagnosis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000175:diagnosis*; D009362:Neoplasm Metastasis; D011247:Pregnancy; D011248:Pregnancy Complications; D014594:Uterine Neoplasms / Q000175:diagnosis*