title: [Interstitial pneumonia in children with acute lymphoblastic leukemia. prophylaxis with pentamidine during induction chemotherapy (author's transl)].
abstract: The influence of pentamidine prophylaxis on incidence and degree of interstitial pneumonia (IP) during a standardized induction chemotherapy in 100 children with acute lymphoblastic leukemia has been investigated. For radiologic evaluation we established three stages of IP. With pentamidine prophylaxis the incidence of IP was reduced from 48% to 9%. In addition, there was a significant reduction of severe or lethal courses.
mesh_terms: D000578:Amidines / Q000008:administration & dosage*; D001604:Berlin; D005860:Germany, West; D007945:Leukemia, Lymphoid / Q000150:complications*; D010419:Pentamidine / Q000008:administration & dosage*; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology / Q000517:prevention & control; D011658:Pulmonary Fibrosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000578:Amidines; D010419:Pentamidine
vernacular_title: Die interstitielle Pneumonie bei Kindern mit akuter lymphoblastischer Leukämie. Prophylaxe mit Pentamidine während der Induktionsbehandlung.