Cellular collaboration in the production of human leucocyte migration inhibition factor.
The participation of cell subpopulations in the expression of leucocyte migration inhibition factor (LMIF) in response to Concanavalin A and Protein A was evaluated for cells isolated from the peripheral blood of five healthy subjects. LMIF activity could not be attributed to the function of T cells, B enriched cells, or monocytes acting alone, or to a combination of B enriched cells and monocytes. The LMIF response was the result of a collaborative event that occurred between T cells and B enriched cells, or between T cells and monocytes.
D001402:B-Lymphocytes / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007958:Leukocyte Count; D008222:Lymphokines / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology; D013205:Staphylococcal Protein A / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology
D008222:Lymphokines; D013205:Staphylococcal Protein A; D003208:Concanavalin A