title: The secretion of pepsin.
abstract: 1. Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial ligation. 3. Analysis of dose-response curves shows that for pepsin secretion the Vmax values were raised by this procedure. 4. Right-sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected that the procedure of right-sided vessel ligation removes a non-competitive inhibitor mechanism to gastric pepsin secretion.
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000378:metabolism*; D008026:Ligation; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D010862:Pilocarpine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013270:Stomach / Q000098:blood supply* / Q000294:innervation; D014628:Vagotomy
chemical_list: D010862:Pilocarpine; D003847:Deoxyglucose; D010434:Pepsin A; D010418:Pentagastrin