Impaired amylase release from the parotid gland of rats treated with reserpine.
Using an automated system for the analysis of amylase, the release of this enzyme was compared in superfused parotid gland segments from control and reserpine treated rats. Stimulant-evoked amylase release was delayed and of smaller magnitude in the glands of the treated animals and a reduction of the transmembrane K+ gradient caused a smaller and short lasting reduction in Ach-evoked release of amylase in the glands from these animals.
D000109:Acetylcholine / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D007700:Kinetics; D010306:Parotid Gland / Q000187:drug effects / Q000201:enzymology*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D000516:alpha-Amylases / Q000378:metabolism
D010656:Phenylephrine; D012110:Reserpine; D000681:Amylases; D000516:alpha-Amylases; D007545:Isoproterenol; D000109:Acetylcholine; D004837:Epinephrine