Demonstration of nuclear antigen binding lymphocytes by the resette method in SLE-patients.
A rosette method suitable for the demonstration of deoxyribonucleic acid and deoxyribonucleoprotein-binding peripheral lymphocytes is described. The results confirmed the existance of a human peripheral lymphocyte subpopulation capable of binding nuclear antigen specifically. The subpopulation was demonstrated in 63 out of 75 SLE-patients; 57 out of 59 SLE-patients being in the active period of the disease revealed nuclear antigenbinding lymphocytes, as against 6 our of 16 patients being in remission.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001666:Binding Sites, Antibody; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation
D000974:Antibodies, Antinuclear