title: [Ultrastructural analysis of the effect of alloxan on the insular apparatus of the pancreas in amphibia].
abstract: Administration of alloxan to Rana temporaria in a dose of 300 mg/kg caused a complex of reactive changes in the pancreas (degranulation of B-cells, of acino-islar cells of B type, and of the exocrine pancreocytes; edema of the secretory granules, lysosome activation, disturbance of the secretory cycle course), which were irreversible in the majority of cells.
mesh_terms: D000496:Alloxan / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D007274:Injections, Intraperitoneal; D007515:Islets of Langerhans / Q000378:metabolism / Q000648:ultrastructure*; D011896:Rana temporaria
chemical_list: D000496:Alloxan
vernacular_title: Ul'trastrukturnyĭ analiz vliianiia alloksana na insuliarnyĭ apparat podzheludochnoĭ zhelezy amfibii.