Lymphocytes eluted from synovial tissue of juvenile rheumatoid arthritis patients.
Synovial tissues from 11 patients with juvenile rheumatoid arthritis were investigated. The elution of lymphocytes was performed according to a procedure previously described for synovial tissue of adult rheumatoid arthritis patients (1). The T lymphocytes were pre dominant (mean: 71%) in all cell suspensions studied, whereas the average proportion of B lymphocytes was 4%. In addition, Fc-receptor-bearing lymphocytes were demonstrable (mean: 8%). Transformation of the lymphocytes was induced by the unspecific mitrogens phytohemagglutinin, pokeweed mitogen, and concanavallin A, whereas antigens such as ppd and candida albicans antigen were usually ineffective.
D000293:Adolescent; D000328:Adult; D000946:Antigens, Fungal; D001171:Arthritis, Juvenile / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D002176:Candida albicans; D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000032:analysis; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D013583:Synovial Membrane / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014373:Tuberculin
D000946:Antigens, Fungal; D007141:Immunoglobulin Fc Fragments; D037102:Lectins; D014373:Tuberculin; D003208:Concanavalin A