title: Immunologic changes in regional lymph nodes of melanoma patients.
abstract: In tumor-draining lymph nodes, humoral immunity is diverted from individually specific, cytotoxic anti-membrane AB to less specific anti-cytoplasmic AB with progression of the disease. Auto-anti-anti-bodies and suppressor cells seem to be involved in  the failure of control of metastasis.
mesh_terms: D000912:Antibodies, Neoplasm / Q000032:analysis*; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D008545:Melanoma / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000912:Antibodies, Neoplasm; D001323:Autoantibodies