title: Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS).
abstract: Bacterial lipopolysaccharides (LPS) have been demonstrated to activate both the classical and the properdin pathways of complement. The lipid A region of the LPS is responsible for classical pathway activation and the polysaccharide region responsible for properdin pathway activation. Classical pathway activation by lipid A does not depend upon antibody to the lipid A and properdin pathway activation proceeds by a lipid A-independent mechanism. The polysaccharide portion of the LPS molecule exerts a modifying influence on the potential anticomplementary activity of the lipid A.
mesh_terms: D003165:Complement System Proteins / Q000378:metabolism*; D004926:Escherichia coli; D008050:Lipid A / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011414:Properdin / Q000378:metabolism*; D012475:Salmonella; D012486:Salmonella typhimurium; D013329:Structure-Activity Relationship
chemical_list: D008050:Lipid A; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D011414:Properdin; D003165:Complement System Proteins