title: On the nature of the transport pathway used for Ca-dependent K movement in human red blood cells.
abstract: This paper is concerned with the mechanism by which energy-depleted human red cells become permeable to K (but not to Na) when they are exposed to Ca. In an attempt to distinguish a diffusion from a mediated process competitive type effects of different ions and their sidedness of action on K transport are considered as well as the action of certain transport inhibitors. While the nature of the interactions implies the involvement of a mediated process (perhaps an altered form of the Na:K pump apparatus) more direct evidence will be needed to make a definitive assessment.
mesh_terms: D001667:Binding, Competitive; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology / Q000502:physiology*; D003864:Depression, Chemical; D004347:Drug Interactions; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D009840:Oligomycins / Q000494:pharmacology; D009994:Osmolar Concentration; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood / Q000494:pharmacology; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
chemical_list: D009840:Oligomycins; D013757:Tetraethylammonium Compounds; D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D011188:Potassium; D002118:Calcium