Studies on aculeacin. I. Isolation and characterization of aculeacin A.
Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including theonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.
D000596:Amino Acids / Q000032:analysis; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D001230:Aspergillus / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008970:Molecular Weight; D051381:Rats; D014249:Trichophyton / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects
D000596:Amino Acids; D000935:Antifungal Agents; D000666:Amphotericin B