Failure to block lymphocyte Fc receptor with anti-B lymphocyte sera (anti-DRW) in man.
Sera harvested from multiparous women or from allograft recipients who had rejected their kidneys and containing various anti-DRW specificities, were studied on peripheral blood or lymph-node lymphocytes bearing or lacking the relevant B-cell alloantigen, for their EA or EAC-rosette-inhibition activity. Inhibition of C3 or Fc-receptor occurred independently of their anti-B lymphocyte cytotoxicity pattern. The same conclusion was reached when lymphocytes were either macrophage depleted or B-lymphocyte enriched. These results do not suggest a relationship in man between B-lymphocyte (DRW) alloantigen and Fc or C3 receptor structure.
D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology; D003176:Complement C3 / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D012397:Rosette Formation
D000961:Antilymphocyte Serum; D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies