Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies.
Two new lymphocyte antigens, provisionally designated Qat-4 and Qat-5 have been identified with two different hybridoma-derived, monoclonal AKR antiC57BL/6 antibodies. These antigens are governed by genes located to the right (distal) end of the H-2 complex, within the Qa-2,3 region. Qat-4 and Qat-5 antigens which do not seem to be identical with Qa-2,3 or TL antigens are absent from Ig/ lymphocytes and thymocytes. They are only present on a fraction of peripheral T cells. Thus, Qat-4 is expressed on 70%, and Qat-5 on 30% of splenic and lymph node T cells, Qat-4 is also found on the majority of Ig- cells from athymic nude mice. These findings illustrate the complexity of the chromosome segment between the H-2D and Tla loci and they emphasize the role of major histocompatibility complex-associated genes for the differentiation of T cells into different subpopulations with possibly distinct immunologic functions.
D000818:Animals; D000936:Antigen-Antibody Complex; D002874:Chromosome Mapping; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D007519:Isoantigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008806:Mice, Inbred AKR / Q000235:genetics / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000276:immunology; D008819:Mice, Nude / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D006183:H-2 Antigens; D007518:Isoantibodies; D007519:Isoantigens