title: Presence and production of migration inhibitory activity in the peritoneal cavity.
abstract: The presence of migration inhibitory (MI) activity was investigated in the delayed hypersensitivity (DH) reaction induced by i.p. injection of PPD into FCA-sensitized guinea-pigs. Peritoneal exudates were studied at several times before and after the induction of the DH reaction and a non-immune control inflammation. Lymphokine (LK) fractions were prepared from individual exudates and tested in a conventional macrophage migration inhibition assay at concentrations determined to occur in vivo. The results suggest a continuous local production of MI activity and an augmented production during development of a DH reaction.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology*; D002452:Cell Count; D005122:Exudates and Transudates / Q000276:immunology; D005260:Female; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008222:Lymphokines / Q000032:analysis; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis*; D014373:Tuberculin / Q000008:administration & dosage
chemical_list: D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors; D014373:Tuberculin; D005620:Freund's Adjuvant