Atypical T-cell leukemia terminating Hodgkin's disease.
A case of Hodgkin's disease is described which developed into a terminal illness characterized by a malignant proliferation of T-cells. The leukemic cells, after optical and ultrastructural analysis, were distinct from those of myelomonocytic, acute lymphoblastic, chronic lymphocytic as well as prolymphocytic leukemia. Their relationship with the T-cell lineage seemed to be confirmed by a highly positive E-rosette test and by cytochemistry which showed focal positivity of acid phosphatase. The importance of this T-cell malignant proliferation is discussed, especially with regard to cellular interactions in Hodgkin's disease.
D000135:Acid Phosphatase / Q000378:metabolism; D000328:Adult; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000150:complications* / Q000648:ultrastructure; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009378:Neoplasms, Multiple Primary / Q000648:ultrastructure*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000648:ultrastructure*
D000135:Acid Phosphatase