title: [Cimetidine in the treatment of peptic ulcer].
abstract: Cimetidine, a non-thiourea-containing histamine H2-receptor antagonist, has been employed in the treatment of peptic ulcer. We studied 50 patients, partly with double-blind method, and partly in a free trial. Duodenal ulcers were completely healed in 80% of the cases, at the control endoscopy after a 4-week period of treatment with cimetidine (1000 mg/day). Peptic ulcer in general healed in 76% of the cases. Gastric secretion was significantly reduced after cimetidine. An important improvement in subjective symptoms was noted in every patient. No toxic effect was noted.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002927:Cimetidine / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004361:Drug Tolerance; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D013276:Stomach Ulcer / Q000188:drug therapy
chemical_list: D006146:Guanidines; D002927:Cimetidine
vernacular_title: La cimetidina nella terapia dell'ulcera peptica.