Immunocytochemical studies for the localisation of measles antigens in multiple sclerosis plaques and measles virus-infected CNS tissue.
Actively demyelinating central nervous system (CNS) lesions from a patient with acute multiple sclerosis (MS) were tested for measles antigens using peroxidase-conjugated antimeasles antibody. No evidence of measles antigens was found. Similarly reacted tissue from 2 patients with chronic MS also revealed no evidence of measles antigens. Identically treated and simultaneously tested measles-infected CNS cultures and human SSPE brain tissue stained strongly for measles antigens. The possible reasons underlying the failure to detect measles antigens in MS are discussed.
D000328:Adult; D000818:Animals; D000956:Antigens, Viral; D002531:Cerebellum / Q000276:immunology; D006224:Cricetinae; D046508:Culture Techniques; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G; D008457:Measles / Q000276:immunology; D008459:Measles virus / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D009928:Organ Specificity; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology
D000956:Antigens, Viral; D007074:Immunoglobulin G