Transient impairment of peripheral blood lymphocyte function during PUVA therapy.
Three parameters of immune function--enumeration of circulating T and B lymphocytes and response of lymphocytes to graduated doses of phytohaemagglutinin (PHA)--were examined serially in eleven patients with psoriasis before, during, and after an intensive course of PUVA therapy. A trend was detected for the lymphocyte response to PHA to fall during the first week of treatment and then rise back towards the pre-treatment level. No alteration was found in the percentage or absolute numbers of circulating T and B lymphocytes. This study shows that routine PUVA therapy can induce an alteration in immune function but that this alteration is slight and short-lived.
D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D008730:Methoxsalen / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D010778:Photochemotherapy; D010835:Phytohemagglutinins / Q000494:pharmacology; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
D010835:Phytohemagglutinins; D008730:Methoxsalen