title: Immunologic surface markers in non-Hodgkin's lymphomas.
abstract: Tissues from 21 patients with non-Hodgkin's lymphomas were examined for immunologic cell surface markers. Patterns of distribution of complement receptor (CR) B lymphocytes and Fc receptor (FcR)-bearing histiocytes in tumor tissue were evaluated and compared to routine histologic preparations of the tumors and to normal tissue. The lymphomatous infiltrates from all 6 cases of nodular, poorly differentiated lymphocytic lymphoma (NPDLL) consisted of dense populations of CR B lymphocytes. Involved tissue from 7 of 8 patients with diffuse, poorly differentiated lymphocytic lymphoma (DPDLL) was predominately comprised of CR B lymphocytes. Discrete nodules of CR B cells were present in a lymph node replaced by DPDLL. FcR were identified on the cells from 1 of 3 cases of histiocytic lymphoma. None of the 4 cases of undifferentiated lymphoma possessed demonstrable surface markers in tissue section; however, the cell suspension from 1 case contained a high percentage of CR B cells. Both CR and T cell markers were present on the cells of DPDLL of childhood.
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002051:Burkitt Lymphoma / Q000276:immunology; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D006644:Histiocytes / Q000276:immunology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000032:analysis; D007158:Immunologic Techniques; D008223:Lymphoma / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
chemical_list: D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins