S-tryptophan concentrations after intestinal bypass in extreme obesity.
Treatment of extreme obesity with jejunoileostomy was followed by a decreased level of S-tryptophan; permanently low concentrations were recorded postoperatively in 29 out of 52 patients. Patients in the low tryptophan group had a higher rate of weight loss and a hgiehr incidecnce of electrolyte disturbances and signs of liver injury. Symptoms of depression and anxiety were slightly more common in patients with low S-tryptophan. The influence of a decreased S-albumin and a deranged amino acid pattern on the non-protein-bound fraction of S-tryptophan needs further investigation. Serum levels of tryptophan rose significantly after rwo weeks' oral supplementation with 1.2 g L-tryptophan daily; this dosage was insufficient to normalize a low S-tryptophan level in patients who have undergone jejunoileostomy.
D000284:Administration, Oral; D000596:Amino Acids / Q000097:blood; D001007:Anxiety / Q000209:etiology; D001835:Body Weight; D002986:Clinical Trials as Topic; D003863:Depression / Q000209:etiology; D006801:Humans; D007421:Intestine, Small / Q000601:surgery*; D007583:Jejunum / Q000601:surgery; D008099:Liver / Q000473:pathology; D009765:Obesity / Q000628:therapy*; D010919:Placebos; D011183:Postoperative Complications; D012709:Serum Albumin / Q000032:analysis; D014364:Tryptophan / Q000008:administration & dosage / Q000097:blood*; D014883:Water-Electrolyte Imbalance
D000596:Amino Acids; D010919:Placebos; D012709:Serum Albumin; D014364:Tryptophan