HLA-B8 in caucasian patients with systemic lupus erythematosus.
HLA antigen frequencies were determined in 27 Caucasians with systemic lupus erythematosus (SLE). A statistically significant association between HLA-B8 and SLE was found. HLA-B8 occurred in 48% of patients and in 18% of controls (P corr approximately equal to 0.005). The relative risk of SLE for HLA-B8 carriers is 4.23. In addition, SLE patients with later onset of disease more frequently had HLA-A1 and/or HLA-B8. There was no association between any HLA antigen and clinical (renal, central nervous system, and lung involvement) or serological (antinuclear and anti-nDNA antibodies) parameters.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D007518:Isoantibodies; D004247:DNA