title: [Specificity of antinuclear autoantibodies in diseases with systemic destruction of connective tissue].
abstract: By using the fluorescent antibody technique several patterns of antinuclear antibodies (ANA) were detected in the systemic connective tissue diseases, as well as in some other diseases and in healthy donors, depending on the character of nuclear fluorescence. Homogeneous nuclear fluorescence, homogeneous fluorescence free of nucleaolar fluorescence, ring-shaped fluorescence, lumpy fluorescence, selective nuclealar fluorescence, nuclear fluorescence in the form of long fine plexiform bands associated with fluorescence in the nuclear membrane region. The latter ANA pattern was found only in several forms of lupus erythematosus, and this fluorescence was different from the previously reported "reticular" and "filamentous" patterns.
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear; D000918:Antibody Specificity; D003095:Collagen Diseases / Q000276:immunology*; D003238:Connective Tissue / Q000276:immunology*; D003239:Connective Tissue Cells; D005455:Fluorescent Antibody Technique; D005767:Gastrointestinal Diseases / Q000276:immunology; D006801:Humans; D008171:Lung Diseases / Q000276:immunology; D008179:Lupus Erythematosus, Discoid / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D009928:Organ Specificity; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D000974:Antibodies, Antinuclear
vernacular_title: O napravlennosti antinuklearnykh autoantitel pri zabolevaniiakh s sistemnym porazheniem soedinitel'noĭ tkani.