Familial lupus. Family studies of HLA and serologic findings.
HLA profiles in 103 members of 4 separate kindred with multiple occurrence of SLE were compatible with the presence of a disease susceptibility factor linked to HLA or a direct effect of antigens B8, A11, and B35 on disease expression. Serum ANA was found in 52.9% of consanguineous, 56.5% of nonconsanguineous relatives of SLE probands, and 5% of controls, a finding that suggests the presence of a transmissible agent in the families. By contrast, lymphocytotoxic antibodies were not increased in relatives compared to controls.
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000302:isolation & purification; D002648:Child; D003241:Consanguinity; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D007074:Immunoglobulin G