[Effect of triiodothyronine and methylthiouracil on the enzymatic activity of biogenic amine metabolism in rat brain synaptosomes].
Triiodothyronine injections are shown to lower DOPA decarboxylation and 5-hydroxytryptophan decarboxylation activity and also to decrease the intensity of serotonin and norepinephrine oxidative deamination in the rats' brain synaptosomes. Hypothyroidism produced by 6-methylthiouracil administration was accompanied by intensification of the DOPA-decarboxylase activity and monamine oxidase transformation into serotonin and norepinephrine with no parallel occurring essential changes in the 5-hydroxytryptophan decarboxylation.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D003641:Deamination; D003653:Decarboxylation; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D008297:Male; D008779:Methylthiouracil / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects* / Q000201:enzymology; D014284:Triiodothyronine / Q000494:pharmacology*
D001679:Biogenic Amines; D014284:Triiodothyronine; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D008779:Methylthiouracil; D009638:Norepinephrine
Vliianie triiodotironina i metiltiouratsila na aktivnost' nekotoryhk fermentov metabolizma biogennykh aminov v sinaptosomakh golovnogo mozga krys.