title: Five-year follow-up results of a collaborative study of therapies for carcinoma of the bladder.
abstract: Results after 5 years of follow-up in a cooperative trial of therapies for operable bladder cancer confirmed preliminary indications of a beneficial effect of preoperative irradiation. Improved survival was experienced by the one-third of the irradiated patients who experienced complete eradication of the tumor as indicated from the resected specimen 30-60 days after a 30-day course of 4,500 rads. These patients had a 55% chance of surviving 5 years as opposed to a 32% chance for those where irradiation did not eradicate the tumor, or similarly for those not irradiated. A postoperative course of chemotherapy with 5-fluorouracial appeared to act detrimentally when given to patients irradiated preoperatively, but may have had a slight benefit when given after surgery alone.
mesh_terms: D002986:Clinical Trials as Topic; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D005472:Fluorouracil