Diminution of prostate by ergoline derivative VUFB--6638 (Dironyl) in rats.
Experiments in male rats showed that the administration of prolactin secretion inhibitor-N-(D-6-methyl-8-isoergolin-I-yl)-N', N'-diethylurea -- led to a decrease of prostate weight, while a simultaneous administration of prolactin prevented this effect. The histological examination showed that the quantity of secretions in the prostate glands are decreased.
D000818:Animals; D004873:Ergolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D009929:Organ Size; D011388:Prolactin / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology
D004873:Ergolines; D014508:Urea; D011388:Prolactin