[Proliferative processes in the epithelium of mouse skin allotransplants following cortisone administration].
Proliferative processes were studied in the epithelium of skin grafts from mice of strain CC57 Brown and that of the skin surrounding the grafts in mice of CBA strain. The chart (Fig 1) illustrates cortisone action on normalization of DNA synthesis in the epithelial cells of the allotransplant. Throughout the experiment in operated animals which received no cortisone (Fig. 2, a and 3, a) a high proliferative activity was observed in the recipient's skin epithelium while it was sharply decreased in the epithelium of the allograft. Repeated cortisone injections gave a reverse picture: inhibition of proliferative processes in the recipient's epithelium and their intensification in the epithelium of the allotransplant.
D000818:Animals; D001345:Autoradiography; D003348:Cortisone / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D003864:Depression, Chemical; D004848:Epithelium; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D016038:Skin Transplantation; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous
D004247:DNA; D003348:Cortisone; D013936:Thymidine
Proliferativnye protsessy v épitelii allotransplantatov kozhi mysheĭ pri vvedenii kortizona.