title: [Creutzfeldt-Jakob disease; clinical, histopathological and electron microscopy study of a case].
abstract: The case of a patient 53 years old that had a picture of cortical impairment and pyramidal disfunction, leading in 6 months to acinetic mutism is reported. The histopathology lead to the diagnostic of Creutzeldt-Jakob disease, with neuronal loss, gliosis and status spongiosus. The electron-microscopic examination showed that the status spongiosus was due to cellular processes, some having vesicular bodies sugestive of pre-synaptic vesicles.
mesh_terms: D001921:Brain / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D011011:Pneumoencephalography
vernacular_title: Molestia de Creutzfeldt-Jakob: estudo clínico histopatológico e eletromicroscópico de um caso.