[Ftorafur concentration in the blood and urine of oncological patients].
The concentration of the active principle of ftorafur in blood and urine varied depending on the activity of metabolic processes in a patient, size and sensitivity of tumor, etc. The concentrations increased in repeat injections of the substance. The efficacy was related with the intensity of formation of active components, but is not dependent on the substance level dtermined in biological fluids of the organism.
D001702:Biopharmaceutics; D001711:Biotransformation; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism*; D005641:Tegafur / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D005641:Tegafur; D005472:Fluorouracil
Kontsentratsiia ftorafura v krovi i moche onkologicheskikh bol'nykh.