[Action of polyene antibiotics on ribosome binding with Candida albicans membranes].
The effect of treatment of the protoplasts and cell membranes of C. albicans with polyenic entibiotics on formation of the ribosomal-membrane complex was studied in vitro. It was shown that amphotericin B and nystatin had no effect on this process. Significant suppression of the ribosome binding with the membranes was observed only in vivo in the presence of levorin. The role of the structural changes occurring in the membranes on formation of the polyen-sterol complex, as well as the role of the lipid components of the membrane in binding of the ribosomes is discussed.
D000666:Amphotericin B / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008565:Membrane Proteins / Q000378:metabolism*; D009761:Nystatin / Q000494:pharmacology; D011090:Polyenes; D011485:Protein Binding / Q000187:drug effects; D012269:Ribosomal Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D008565:Membrane Proteins; D011090:Polyenes; D012269:Ribosomal Proteins; D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B
Deĭstvie polienovykh antibiotikov na sviazyvanie ribosom s membranami Candida albicans.