Chromosomes and causation of human cancer and leukemia. XXXIII. 5q-- in a case of acute lymphoblastic leukemia (ALL).
The case of a 4-year-old boy with ALL, possibly developing subsequent to a lymphoma involving the thoracic cavity, which was shown to be of the T-cell type, is presented. The leukemic cells had a 5q-- anomaly, which had previously been described only in cases of refractory anemia and/or AML. The 5q-- abnormality was invariably accompanied by a 9p-- chromosome in the leukemic cells. The interstitial deletion leading to the 5q-- chromosome was shown with banding techniques to be similar to that described previously in myeloproliferative disorders. Some aspects of the 5q-- anomaly in ALL and its relation to previous experience with this karyotypic change are discussed.
D000941:Antigens; D002462:Cell Membrane / Q000276:immunology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002905:Chromosomes, Human, 4-5; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens