title: Constant-pressure aortic root perfusion versus cardioplegia and hypothermia. Comparison of methods of myocardial protection.
abstract: Both coronary perfusion and hypothermic cardioplegia are widely used methods of myocardial protection during aortic valve replacement. A theoretical objection to coronary perfusion is that it is not synchronized with cardiac contractions. Accordingly, a special pump was designed to provide perfusion at a constant range of pressure. Twenty dogs were studied during 4 hours of bypass. In six dogs no manipulations were carried out and hearts were allowed to beat in a nonworking state. Seven dogs underwent 2 hours of aortic cross-clamping and constant-pressure aortic root perfusion. Seven dogs underwent 2 hours of uninterrupted aortic occlusion with myocardial protection being maintained by cold potassium-induced arrest, Contractility did not change significantly in any of the three groups. All animals demonstrated significant hyperemia after bypass but normal endocardial/epicardial flow ratios. Although compliance deteriorated in all groups, the most striking changes were seen following 4 hours of bypass alone or constant-pressure aortic root perfusion. Hypothermic potassium arrest, in contrast, provided a slightly greater degree of myocardial protection, perhaps both by limiting the degree of ischemic injury directly and by excluding the heart from the circulating blood and the pump oxygenator system.
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000601:surgery; D001026:Coronary Artery Bypass / Q000295:instrumentation / Q000379:methods*; D003326:Coronary Circulation; D003331:Coronary Vessels; D004285:Dogs; D006324:Heart Arrest, Induced; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D007036:Hypothermia, Induced; D007511:Ischemia / Q000517:prevention & control; D010477:Perfusion / Q000295:instrumentation*