Antimutagenic effects of spermine and guanosine in continuous cultures of Escherichia coli mutator strain mutH.
In E. coli strain RH531 containing mutator gene mutH-, whose mechanism of enhanced mutability depends upon DNA replication, spermine and guanosine reduce the rates of mutation to T5R and to increased fitness.
D004926:Escherichia coli / Q000187:drug effects*; D006151:Guanosine / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects*; D013096:Spermine / Q000494:pharmacology*
D006151:Guanosine; D013096:Spermine