title: [Differentiation of the palatine tonsillar tissues of the human fetus].
abstract: Differentiation of epithelial and lymphoid tissues of the palatine tonsils was studied in human embryos at the age of 8-34 weeks of development by means of histochemical, immunomorphological and morphometric methods. The anlage of the palatine tonsils appears at the age of 9 weeks of fetal development. At the age of 13-14 weeks of fetal development the tonsil suspension contains 2 subpopulations of lymphocytes possessing properties of T-cells differing in the ability of their superficial receptors to interact with sheep erythrocyte antigens forming rosettes (RFC--rosette forming cells) and with antigens of their own erithrocytes (autoRFC). The number both increases sharply by the 16th week of gestation. Simultaneously, essential alterations are noted in epithelial and lymphoid tissues. In epithelium of crypts cornified cells appear; the amount of lymphoid tissue increases sharply, primary follicles without reactive centers appear, lymphocytic infiltration of epithelium occurs. The amount of RFC does not change considerably, and the amount of autoRFC has a tendency towards some increase. From the data obtained, it is possible to suggest that human palatine tonsils already at embryonic period participate in functioning of immunogenic organs and in maintaining of immunologic homeostasis of the fetal organism.
mesh_terms: D002454:Cell Differentiation; D004848:Epithelium / Q000196:embryology; D005260:Female; D005865:Gestational Age; D006801:Humans; D008221:Lymphoid Tissue / Q000196:embryology; D014066:Palatine Tonsil / Q000196:embryology*; D011247:Pregnancy; D013601:T-Lymphocytes / Q000166:cytology
vernacular_title: Differentsirovka tkaneĭ nebnykh mindalin ploda cheloveka.