Preferential uptake of estradiol in the pituitary and hypothalamus of mature male rats in the presence of testosterone.
Simultaneous intravenous injection of 3H-estradiol and 14C-testosterone into adult male rats resulted in significant concentration of both labels in the blood and the diencephalon 2 h after the injection. In the pituitary--hypothalamic area only estradiol derived radioactivity could be detected, while testosterone derived 14C label was not found. The results are interpreted to indicate that in males estradiol, not testosterone, may provide the homeostatic balance between the gonads and the hypothalamo-pituitary axis.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000378:metabolism*; D007034:Hypothalamus, Posterior / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D051381:Rats; D011987:Receptors, Steroid / Q000378:metabolism; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
D011987:Receptors, Steroid; D013739:Testosterone; D004958:Estradiol