[Effect of the peroral use of the antitumor antibiotic, carminomycin, on the immunological reactivity of the body of animals].
Carminomycin administered orally to mice for many times in doses of 2.5 and 1.25 mg/kg induced suppression of hemagglutinine production to sheep erythrocytes and formation of immunologically competent cells in the spleen of test animals. The content of DNA and RNA in the spleen of the test animals treated with carminomycin and sheep erythrocytes was somewhat lower than that in the control mice immunized but not treated with the antibiotic. Carminomycin prolongated the life time of the skin graft by 6.5 days as compared to that of the skin homotransplant in the control animals. The oral use of carminomycin in a dose of 2.5 mg/kg induced a statistically significant decrease in the absorption capacity of the cells of the reticuloendothelial system of the animals.
D000284:Administration, Oral; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002360:Carubicin / Q000008:administration & dosage*; D004247:DNA / Q000032:analysis; D006385:Hemagglutination Inhibition Tests; D006388:Hemagglutinins / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D012157:Mononuclear Phagocyte System / Q000187:drug effects; D012313:RNA / Q000032:analysis; D016038:Skin Transplantation; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D014181:Transplantation Immunology / Q000187:drug effects; D014184:Transplantation, Homologous
D000903:Antibiotics, Antineoplastic; D006388:Hemagglutinins; D012313:RNA; D004247:DNA; D002360:Carubicin
Vliianie peroral'nogo primeneniia protivoopukholevogo antibiotika karminomitsina na immunologicheskuiu reaktivnost' organizma zhivotnykh