title: The effect of cholestyramine on serum lipids and platelet aggregation of hypercholesterolemic children (type II A) while on high linoleic acid diet.
abstract: 25 children with familial hypercholesterolemia (type II A) were treated with cholestyramine or placebo in a cross over study during 2 periods of each 10 weeks. The medication was added to a high linoleic acid diet, which had been started at least 1 year earlier. Serum lipids and platelet aggregation were investigated at the end of the 2 periods. On cholestyramine, serum cholesterol levels decreased significantly, whereas the linoleate and oleate content of cholesterylesters and serum triglycerides did not change systematically. Platelet aggregation time, measured with a filtragometer, did not systematically change either.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D008041:Linoleic Acids / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D010919:Placebos; D010974:Platelet Aggregation / Q000187:drug effects*; D014280:Triglycerides / Q000097:blood
chemical_list: D008041:Linoleic Acids; D008055:Lipids; D010919:Placebos; D014280:Triglycerides; D002792:Cholestyramine Resin; D002784:Cholesterol