Endotoxin-induced serum factor controlling differentiation of bone-marrow-derived lymphocytes.
Serum from bacillus Calmette-Guerin-infected mice injected with endotoxin induces the appearance of surface immunoglobulin, Ia antigen, and complement receptor on the surface of precursor bone-marrow-derived (B) cells. While endotoxin itself causes phenotypic conversion of both thymus-derived (T) cells and B cells in vitro, the endotoxin-induced serum factor was found to be a selective inducer of B cell differentiation. Spleen cells rendered immunodeficient by removal of B cells bearing the complement receptor regained the capacity to cooperate with helper T cells and to produce antibody against red cell antigens in vitro upon upon addition of the serum factor to the culture medium. Thus, a factor that controls selective phenotypic and functional differentiation of B cells has been identified and can now be characterized,
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001500:BCG Vaccine; D001665:Binding Sites; D001769:Blood; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D003165:Complement System Proteins / Q000378:metabolism; D004731:Endotoxins / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology*; D007106:Immune Sera; D007519:Isoantigens; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology*; D009368:Neoplasm Transplantation; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013946:Thymopoietins / Q000494:pharmacology
D001500:BCG Vaccine; D004731:Endotoxins; D006023:Glycoproteins; D007106:Immune Sera; D007519:Isoantigens; D011947:Receptors, Antigen, B-Cell; D013946:Thymopoietins; D003165:Complement System Proteins