High incidence of horse serum protein allergy in various autoimmune disorders.
In 186 persons (68 patients suffering from different so-called autoimmune diseases, 30 kidney recipients, 38 control patients from a surgical ward, and 50 healthy volunteers) the immune response to horse IgG was examined. The lowest rate of sensitization was found in kidney transplant recipients (3%) and the highest in autoimmune patients (33%). After excluding 39 patient who had received horse serum treatment prior to the examination, it was found that without previous injection of horse serum, 27% of the patients with autoimmune disease were sensitized to horse IgG. Compared to the other groups (kidney transplant recipients, 4%: surgical controls, 0%; healthy volunteers, 3%), this difference was statistically significant (p is less than 0.01).
D000485:Allergens; D000818:Animals; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology*; D005260:Female; D006736:Horses / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D008297:Male
D000485:Allergens; D001798:Blood Proteins; D007074:Immunoglobulin G