3'-deoxyadenosine and implantation of delayed blastocysts in mice.
Pregnant mice were ovariectomized 3 days after mating and pregnancy was maintained by progesterone treatment. Different regimens of intraperitoneal injections of 3'-deoxyadenosine were applied 3 days after ovariectomy. Repetition of the injections at 3 h intervals induced a significant rate of implantation by delayed blastocysts. Other types of treatment with 3-deoxyadenosine as well as adenosine injections were found to be ineffective. Paradoxically, 3'-deoxyadenosine treatment had an adverse effect on the overall pregnancy rate found at autopsy.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects / Q000502:physiology; D002369:Castration; D003839:Deoxyadenosines / Q000008:administration & dosage / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects*; D010065:Embryo Implantation, Delayed / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology
D003839:Deoxyadenosines; D011374:Progesterone; D004958:Estradiol