The relevance of 25-hydroxycalciferol measurements in sera of patients with renal failure.
Iliac crest biopsies and serum specimens were obtained from 36 non-dialyzed uraemic patients. The mean serum 25-hydroxycalciferol concentration of the patients was lower than that of normal subjects and a significant correlation was found between 25-hydroxycalciferol values and the severity of osteomalacia. Parathyroid osteopathy was significantly correlated with serum immunoreactive parathyroid hormone but not with serum 25-hydroxycalciferol values. While normal serum 25-hydroxycalciferol concentrations in uraemic patients do not exclude the presence of osteomalacia, a low concentration is virtually diagnostic of this disorder.
D000941:Antigens; D004872:Ergocalciferols / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D010018:Osteomalacia / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D010281:Parathyroid Hormone / Q000097:blood
D000941:Antigens; D004872:Ergocalciferols; D010281:Parathyroid Hormone