An acquired cell-directed inhibitor of neutrophil chemotaxis and hypogammaglobulinemia.
An unusual combination of host defense abnormalities was demonstrated in an adult male with recurrent pulmonary infections due to a variety of microorganisms. Polymorphonuclear neutrophil chemotaxis was defective. Other neutrophil and T-lymphocyte function tests were normal. The patient's serum also showed a severe deficiency of IgG, no detectable IgA, IgM, or IgD, and increased IgE. The chemotactic defect was shown to be due to a cell-directed inhibitor in the patient's serum. The effect of the inhibitor on chemotaxis could be antagonized by factors in normal serum. The chemotaxis defect persisted for several months, but eventually returned to normal.
D000328:Adult; D000361:Agammaglobulinemia / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008297:Male; D009504:Neutrophils / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E