Ontogeny of lateral preoptic unit activity in rats.
Extracellular single unit recordings were made from units within the lateral preoptic area (LPO) of infant rats from 1 day of age through 31 days of age (postweaning). The rats were anesthetized with dial-urethane and basal (spontaneous) spike rates were recorded for 10--20 min. The rats also received pain-arousal stimulation (tail-pinch and sc injection of formalin solution), and osmotic stimulation (sc or ip injection of hyperosmotic NaCl or sucrose solutions). LPO units were spontaneously active in neonatal rats; however, basal spike rates increased during development. Also increasing during development was the percentage of LPO units which displayed alteration of spike rate in response to hyperosmotic injections (osmosensitive). However, LPO units were found that were responsive to severe pain-arousal stimulation at all ages tested. The developmental changes in LPO unit activity characteristics paralleled the morphological development of LPO neurons and the development of osmotically induced drinking behaviors.
D000375:Aging; D000818:Animals; D001143:Arousal / Q000502:physiology; D005071:Evoked Potentials; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D014882:Water-Electrolyte Balance