The reactions of 1.0 nanometre diameter plutonium-238 dioxide particles with rat lung fluid.
The reactions of 1.0 nm particles of plutonium-238 dioxide with rat lung fluid have been studied both in vivo and in vitro. In both cases two products have been identified, (i) plutonium-labelled pulmonary surfactant and (ii) a heterogeneous plutonium-labelled material isolated by column chromatography. The formation of plutonium-labelled pulmonary surfactant results in the rapid translocation of plutonium from lungs to blood and in a high urinary excretion relative to administered plutonium citrate.
D000818:Animals; D002499:Centrifugation, Density Gradient; D002951:Citrates / Q000494:pharmacology; D005260:Female; D008168:Lung / Q000378:metabolism*; D010087:Oxides / Q000378:metabolism* / Q000652:urine; D010316:Particle Size; D011005:Plutonium / Q000378:metabolism* / Q000494:pharmacology / Q000652:urine; D011663:Pulmonary Surfactants; D051381:Rats; D012119:Respiration; D013997:Time Factors; D014018:Tissue Distribution
D002951:Citrates; D010087:Oxides; D011663:Pulmonary Surfactants; D011005:Plutonium