Experimental smooth muscle antibodies.
Attempts were made to induce smooth muscle antibody (SMA) in rats by various procedures causing cell necrosis. Ligation of a liver lobe and cryosurgical damage to a liver lobe both resulted in subsequent appearance of SMA, provided the damage tissue was not removed. Transfer of the damaged liver tissue to the peritoneal cavity of a normal rat did not result in SMA production in the recipient. The SMA produced showed anti-actin and anti-heavy meromyosin specificity. Damage induced by hepatotoxic agents failed to give rise to SMA.
D000199:Actins / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D008099:Liver / Q000276:immunology / Q000293:injuries; D009130:Muscle, Smooth / Q000276:immunology*; D015879:Myosin Subfragments / Q000276:immunology; D009336:Necrosis; D051381:Rats
D000199:Actins; D015879:Myosin Subfragments