[Acute lymphoblastic leukemia in children. The use of antisera specific for lymphocyte populations in a classification trial].
Mononuclear cells from 14 children with acute lymphoblastic leukaemia (ALL) were studied using several lymphocyte membrane markers: E-rosettes, "active" E-rosettes, surface immunoglobulins, EA-rosettes. The use of these techniques and of three specific heterologous antisera directed against T and B cell antigens enabled the discrimination of three different ALL types according to the stage of cell maturation at which it is likely that neoplastic differention occured: T-cell ALL, pre-thymic cell ALL, and "non-T non-B" cell ALL showing only HLA-DR antigens.
D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007106:Immune Sera; D007223:Infant; D007945:Leukemia, Lymphoid / Q000145:classification* / Q000175:diagnosis / Q000276:immunology; D008214:Lymphocytes / Q000145:classification; D008297:Male; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology
D007106:Immune Sera
Leucoses aigües lymphoblastiques de l'enfant. Utilisation d'antisérums spécifiques des populations lymphocytaires en vue d'un essai de classification.