Intraperitoneal foreign body reaction in rodents.
In five experiments with female Marsh mice and male and female Evans rats, open-end cylinders of tin were implanted intraperitoneally with litter mates serving as surgical controls. The experiments were terminated 18-24 months later. The long-term local intraperitoneal foreign-body reaction with some cylinders remaining unanchored, frequent failure to develop a fibrous capsule at the outside of the tin cylinder, and a degree of lympho-histiocytic involvement and adenomatous hyperplasia in the fibrosis within the tin cylinder differed from the foreign-body reaction at the subcutaneous site characterized by avascular, cell-poor fibrosis with fibroblasts. In all the implanted rat series, a significant number of local sarcomas, 30-50% of which metastasized, developed with none in the corresponding controls. The incidences of spontaneous lymphoid tumors were decreased or not increased for the tin-implant series as compared with controls. This indicated that the local solid-state carcinogenic process was only partially, if at all, dependent upon the cell type (lymphocyte) that demonstrated a spontaneous inherently malignant potential.
D000818:Animals; D005260:Female; D005549:Foreign-Body Reaction / Q000150:complications / Q000503:physiopathology*; D008223:Lymphoma / Q000209:etiology; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D010529:Peritoneal Cavity; D010534:Peritoneal Neoplasms / Q000209:etiology; D051381:Rats; D012509:Sarcoma / Q000209:etiology; D013045:Species Specificity; D014001:Tin
D014001:Tin