Mutagenicity of polycyclic hydrocarbons. II. Monitoring genetical hazards of chrysene in vitro and vivo.
Mutagenicity tests were performed with chrysene in the Salmonella/microsome test, NMRI-mice oocytes, bone-marrow cells and spermatogonia of Chinese hamsters. Only in mice oocytes was a weak but significant increase of structural chromosome aberrations observed. Correlations were found between weak carcinogenic and observed weak mutagenic activities of chrysene in vitro and in vivo.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D002911:Chrysenes / Q000378:metabolism / Q000633:toxicity*; D006224:Cricetinae; D005260:Female; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009865:Oocytes / Q000187:drug effects; D010616:Phenanthrenes / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013093:Spermatogonia / Q000187:drug effects
D002911:Chrysenes; D009153:Mutagens; D010616:Phenanthrenes