T-cell function in atopic dermatitis. Controlled examination of concanavalin A dose-response relations in cultured lymphocytes.
The Concanavalin A (Con A) stimulation response of peripheral lymphocytes in vitro was found to be decreased statistically significant (alpha = 0.005) in patients with light atopic dermatitis, Strictly matched pairs were examined. Using ten graded concentrations of Con A, dose-response relations of the pairs were demonstrated, differences were more evident at lower suboptimal concentrations. Background DNA-synthesis of the patients was elevated.
D002478:Cells, Cultured; D003208:Concanavalin A; D004247:DNA / Q000096:biosynthesis; D003876:Dermatitis, Atopic / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D003208:Concanavalin A; D007073:Immunoglobulin E; D004247:DNA