Selective destruction of 5-hydroxytryptamine receptors by neuraminidase.
The responses of isolated frog skin to 5-hydroxytryptamine (increased active sodium transport and decreased passive chloride permeability) are diminished by incubation with the enzymes neuraminidase and N-acetylneuraminic acid aldolase but only in the absence of Ca2+ and presence of EDTA. The responses induced by oxytocin, adrenalin and aldosterone are unaffected by enzyme treatment.
D000818:Animals; D001001:Anura; D001692:Biological Transport / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology; D009439:Neuraminidase / Q000494:pharmacology*; D011896:Rana temporaria; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D002712:Chlorides; D011954:Receptors, Dopamine; D012964:Sodium; D009439:Neuraminidase; D004298:Dopamine