Uptake of catecholamines by human cardiac muscle in vitro.
Noradrenaline uptake was studied using heart muscle from 102 patients undergoing cardiac surgery. Slices of right atrium were incubated in Krebs-Henseleit solution containing 1.3 x 10(-7) M 3H-noradrenaline. Uptake was lower in failing heart muscle and was inhibited not only by increasing the noradrenaline concentration in the incubating medium but also by adding the drugs desmethylimipramine, amitryptyline, and ouabain.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000494:pharmacology; D016275:Atrial Function; D001692:Biological Transport / Q000187:drug effects; D002648:Child; D001026:Coronary Artery Bypass; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects; D006331:Heart Diseases / Q000503:physiopathology*; D006351:Heart Valves / Q000601:surgery; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology* / Q000502:physiology; D010042:Ouabain / Q000494:pharmacology
D000639:Amitriptyline; D010042:Ouabain; D003891:Desipramine; D009638:Norepinephrine