[Effect of highly purified thymus factor on the cellular and humoral indices of immunity in thymectomized mice].
Effect of homogeneous polypeptide thymus factor of mol weight about 5000 (thymarin-III) on cellular and humoral immune responses of thymectomized adult CBA mice was studied. Thymectomy proved to greatly decrease the number of T-cells in the spleen. Accordingly, the capability of these mice to produce both IgM and IgG antibody-forming cells in response to the thymus-dependent antigen (sheep red blood cells) was significantly depressed. Subcutaneous injections of thymarin-III (1 microgram per g of body weight) for 7 days completely restored the T-cell spleen population and normalized the animals' immune response.
D000373:Agglutinins / Q000096:biosynthesis*; D000818:Animals; D000921:Antibody-Producing Cells; D002452:Cell Count; D006388:Hemagglutinins / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy; D013949:Thymus Extracts / Q000494:pharmacology*
D000373:Agglutinins; D006388:Hemagglutinins; D013949:Thymus Extracts
Vliianie vysokoochishchennogo faktora timusa na kletochnye i gumoral'nye pokazateli immuniteta u timéktomirovannykh mysheĭ.