Fenoprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
Fenoprofen1 (dl-2-[3-phenoxyphenyl]propionic acid) is a new non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Published data suggest that in rheumatoid arthritis, fenoprofen 2.4 g daily is comparable in effectiveness with moderate doses of aspirin (3.6 to 4 g daily), but generally causes fewer and milder side-effects at the dosages used. In published comparisons with other non-steroidal anti-inflammatory agents of the same chemical group, it is closely comparable with naproxen in effectiveness but tends to cause more minor side-effects than naproxen. However, as no one of the non-steroidal anti-inflammatory agents is the most suitable drug for all patients requiring such therapy, fenoprofen should be considered along with the other drugs of its type in the initial treatment of the arthritic patient. Fenoprofen has compared favourably with phenylbutazone in osteoarthrosis of the hips and with aspirin in osteoarthrosis of the shoulders, hips, knees and spine. Its exact place in the management of gout and ankylosing spondylitis remains to be determined.
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001792:Blood Platelets / Q000187:drug effects; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D004890:Erythema / Q000503:physiopathology; D005260:Female; D005279:Fenoprofen / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects; D006073:Gout / Q000188:drug therapy; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D007700:Kinetics; D010003:Osteoarthritis / Q000188:drug therapy; D010666:Phenylpropionates / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism; D012216:Rheumatic Diseases / Q000188:drug therapy*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010666:Phenylpropionates; D011453:Prostaglandins; D005279:Fenoprofen