Angioimmunoblastic lymphadenopathy: a T-cell deficiency.
The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done including quantitation of B and T-cells, antigen stimulation of lymphocytes in vitro, skin tests and skin window. Impairment of cell mediated immunity, decreased T-lymphocytes and increased B-lymphocytes were found. A decreased migration of lymphocytes in the skin window was also found compatible with immunosuppression. A possible presumptive pathogenetic mechanism is described although the cause of this recently described entity remains unknown.
D001402:B-Lymphocytes / Q000276:immunology; D002464:Cell Migration Inhibition; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation; D008231:Lymphopenia / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*
D011241:Prednisone