Induction of nephrocalcinosis in rabbit kidneys after long-term exposure to a streptococcal teichoic acid.
New Zealand white rabbits were administered soluble lipoteichoic acid from Streptococcus pyogenes 1-RP41 on alternate days for up to 30 days. An increased incidence of renal cortico-medullary calculi was observed after day 21; the use of fluorescent-labeled anti-teichoic acid antibody located teichoic acid predominantly in the cortical-associated tubules.
D000818:Animals; D005260:Female; D007668:Kidney / Q000382:microbiology*; D007669:Kidney Calculi / Q000473:pathology; D008297:Male; D009397:Nephrocalcinosis / Q000139:chemically induced*; D011817:Rabbits; D013297:Streptococcus pyogenes / Q000276:immunology*; D013682:Teichoic Acids; D013997:Time Factors
D013682:Teichoic Acids