On the mechanism of vestibular disturbances caused by industrial solvents.
The industrial solvents xylene, styrene, trichloroethylene and methylchloroform administered to rabbits caused a positional nystagmus and disturbances in the nystagmus response to rotatory acceleration. The positional nystagmus had a beat direction the opposite to positional alcohol nystagmus, which was in similar experiments elicited by methanol, ethanol and propanol. The three alcohols needed a ten times higher blood concentration to cause a nystagmus than the solvents did.
D000433:1-Propanol / Q000633:toxicity; D000818:Animals; D001463:Barbiturates / Q000633:toxicity; D001640:Bicuculline / Q000633:toxicity; D002698:Chloralose / Q000633:toxicity; D004584:Electronystagmography; D000431:Ethanol / Q000633:toxicity; D005133:Eye Movements / Q000187:drug effects*; D000432:Methanol / Q000633:toxicity; D009787:Occupational Medicine; D010852:Picrotoxin / Q000633:toxicity; D011817:Rabbits; D012997:Solvents / Q000633:toxicity*; D013343:Styrenes / Q000633:toxicity; D014240:Trichloroethanes / Q000633:toxicity; D014241:Trichloroethylene / Q000633:toxicity; D014722:Vestibule, Labyrinth / Q000187:drug effects*; D014992:Xylenes / Q000633:toxicity
D000433:1-Propanol; D001463:Barbiturates; D001640:Bicuculline; D002698:Chloralose; D000431:Ethanol; D000432:Methanol; D010852:Picrotoxin; D012997:Solvents; D013343:Styrenes; D014240:Trichloroethanes; D014241:Trichloroethylene; D014992:Xylenes