Prophylactic antibiotics for women undergoing vaginal hysterectomy.
A triple-blind prospective study of women undergoing vaginal hysterectomy was conducted to compare cefazolin, cephaloridine and no antibiotic, Both cefazolin and cephaloridine were given preoperatively, whereas only cephaloridine was given postoperatively. One gram of cefazolin given intramuscularly on call to the operation room was found to be a safe and effective antibiotic for prophylaxis against febrile morbidity. The proper utilization of prophylactic antibiotics seems to be in the immediate preoperative period. The use of antibiotics after the first day of surgery is unnecessary.
D000328:Adult; D000368:Aged; D002437:Cefazolin / Q000627:therapeutic use*; D002509:Cephaloridine / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004927:Escherichia coli Infections; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007045:Hysterectomy, Vaginal / Q000009:adverse effects; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology
D002511:Cephalosporins; D002437:Cefazolin; D002509:Cephaloridine