Investigations on the mechanism of action of narciclasine.
The Authors have investigated the possible interaction between narciclasine and DNA using various physico-chemical techniques useful for demonstrating the complex formation between a small molecule and a marcomolecule. The data obtained clearly indicate that a complex between DNA and narciclasine does not occur. The mechanism of the antimitotic activity of narciclasine must therefore be of a different nature, such as interference with the enzymatic systems involved in the duplication of DNA or with the protein structures involved in nuclear division.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002499:Centrifugation, Density Gradient; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D066298:In Vitro Techniques; D008938:Mitosis / Q000187:drug effects; D010617:Phenanthridines / Q000494:pharmacology*; D012487:Salmonidae
D000470:Alkaloids; D010617:Phenanthridines; D004247:DNA