Anti-tumor immunity in B lymphocyte-deprived mice. I. Immunity to a chemically induced tumor.
Immunity to a syngeneic methylcholanthrene-induced tumor was studied in (C57BL/6 X C3H)F1 males, treated continuously from birth with a rabbit anti-mouse IgM serum. Such mice have been shown to be selectively depleted of Ig-bearing lymphocytes and incapable of synthesizing antibodies. In the experiments reported, a heightened resistance of these mice to the syngeneic fibrosarcoma was demonstrated. This resistance was manifest in significantly slower tumor growth at the site of injection, as well as a lower incidence of spontaneous pulmonary metastasis.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D003433:Crosses, Genetic; D007075:Immunoglobulin M; D007165:Immunosuppression Therapy; D007274:Injections, Intraperitoneal; D008212:Lymphocyte Depletion; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007075:Immunoglobulin M; D008748:Methylcholanthrene