The predisposition to infection following hemorrhagic shock.
Subsequent life threatening gram-negative infection in patients successfully resuscitated from hemorrhagic shock is becoming increasingly common. Following hemorrhagic shock and resuscitation, Sprague-Dawley rats were given Escherichia coli intraperitoneally to simulate the clinical setting in which peritoneal contamination and hypovolemic shock occur concurrently. A sublethal dosage of bacteria resulted in a 100 per cent mortality. This suggests that hemorrhagic shock, even when treated promptly and effectively, predisposes to infection.
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D004927:Escherichia coli Infections / Q000276:immunology / Q000473:pathology; D010587:Phagocytosis; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000209:etiology; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000401:mortality / Q000473:pathology