title: Pulmonary single circulation dilution curves of T-1824, sodium, and tritiated water in intact piglets.
abstract: In order to assess pulmonary endothelial permeability to sodium in the immature lung, 15 multiple indicator dilution curves were done in eight intact piglets. An indicator bolus consisting of T-1824, 22Na, and tritiated water (THO) was delivered into the right atrium and blood was sampled from the aorta. The concentration of sodium, expressed as a fraction of the quantity injected and of the corresponding fractional concentration of T-1824, was averaged for the samples prior to recirculation. The permeability-surface area product calculated from these data is 2.0 X 10(-5) cm sec-1, and is virtually identical with the value reported elsewhere for adult dogs. Extravascular lung water obtained from the triated water and T-1824 curves averaged 64%, whereas that obtained from the 22Na and T-1824 curves averaged 23% of blood-free lung water.
mesh_terms: D000818:Animals; D001834:Body Water; D002463:Cell Membrane Permeability; D004727:Endothelium / Q000378:metabolism; D005070:Evans Blue / Q000378:metabolism; D005110:Extracellular Space; D007201:Indicator Dilution Techniques; D008168:Lung / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D013552:Swine; D014316:Tritium; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D014316:Tritium; D005070:Evans Blue; D012964:Sodium