title: Vestibular suppression in peripheral and central vestibular disorders.
abstract: Caloric tests have been carried out both in the presence of optic fixation and in total darkness upon normal subjects, patients with peripheral vestibular disorders and patients with central vestibular lesions. Nystagmic responses were recorded electronystagmographically and measurements made of latency and duration of response, maximum slow component velocity and beat frequency. The relative enhancement of the response in darkness is expressed as a fixation index: maximum slow component velocity in darkness maximum slow component velocity with fixation. Compared to the normal group the peripheral group were found to have abnormally high fixation indices, the central group abnormally low. A hypothesis has been developed of the nervous mechanisms underlying the suppressive effects of optic fixation in both peripheral and central lesions which accords well with the available clinical, anatomical and physiological data. The clinical implications of the findings are discussed both in respect of their localizing value and relevance to current innovations in the design of caloric tests.
mesh_terms: D001932:Brain Neoplasms / Q000503:physiopathology*; D002150:Caloric Tests; D004584:Electronystagmography; D005403:Fixation, Ocular; D006801:Humans; D007759:Labyrinth Diseases / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000503:physiopathology*