Participation of C3 in intracellular killing of Candida albicans.
Using new objective methods for measuring, independently, phagcytosis and killing, it was demonstrated that Candida albicans opsonized by C3-deficient serum was ingested by not killed in vitro by human polymorphonuclear leukocytes. Killing could be induced by adding purified C3 to the C3-deficient serum. It is concluded that C3 participates directely in the intracellular process leading to phagocytic killing of C. albicans.
D002176:Candida albicans; D003176:Complement C3; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D010587:Phagocytosis
D003176:Complement C3