Decreased hybrid susceptibility to murine myeloma grafts.
The behavior of BALB/c myeloma transplants in (C57BL/10 X BALB/c)F1 hybrids was investigated. The F1 hybrids were less susceptible to the grafts than were the parental BALB/c hosts. Host susceptibility was X-ray and cyclophosphamide sensitive, but an immune hypothesis was not favored since no memory was demonstrable. Males were less susceptible than females, and rabbit antithymus serum had no effect on susceptibility.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D003520:Cyclophosphamide / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006824:Hybridization, Genetic; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009101:Multiple Myeloma / Q000276:immunology*; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014965:X-Rays
D000961:Antilymphocyte Serum; D003520:Cyclophosphamide