Autoimmunity induced by injection of virus-modified cell membrane antigens in syngeneic mice.
C3H/Bi mice developed autoantibodies after repeated inoculations of isolated membranes from primary tissue cultures of a syngeneic ascites lymphoma in which Newcastle disease virus had grown. This was in addition to the tumor transplantation resistance and cytotoxic antibodies previously demonstrated. The complement-fixing antibodies were completely removed from sera by adsorption with ascites tumor cells but only partially by normal mouse liver powder or C3H/Bi erythrocytes. With continued immunization, antibodies to deoxynucleoprotein and heterophile reagins also appeared. After several months, mice showing these serological reactions died with a wasting disease characterized by loss of lymphoid tissue and scarred, atrophied kidneys. No significant antibody response or autoimmune disease occurred in mice receiving membranes from uninfected syngeneic ascites lymphoma.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D000956:Antigens, Viral / Q000096:biosynthesis*; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000401:mortality; D002462:Cell Membrane / Q000276:immunology*; D003168:Complement Fixation Tests; D003588:Cytopathogenic Effect, Viral; D007163:Immunosorbent Techniques; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D009522:Newcastle disease virus / Q000276:immunology*; D013045:Species Specificity
D000974:Antibodies, Antinuclear; D000956:Antigens, Viral; D001323:Autoantibodies