Effect of anti-mouse type-1 interferon globulin on the evolution of Moloney sarcoma virus induced disease in mice.
The prolonged administration of potent sheep anti-mouse type-1 interferon globulin (anti-IF IgG) had a marked potentiating effect on Moloney sarcoma virus (MSV) infection in mice. The extent of resistance to the MSV-induced disease was age-related. In 4-week-old BALB/c mice, anti-IF IgG consistently induced 70-80% mortality due to the progression of early or late tumours and erythroleukaemia, whereas mortality of control mice was significantly lower. The same effect was obtained in 1-year-old BALB/c mice. However, in 4-week-old C57BL/6 or 6-week old BALB/c mice, anti-IF IgG enhanced only the growth of early tumours but had no effect on their regression. Antigenic stimulation with normal sheep globulin suppressed the growth of early tumours in suckling BALB/c or C57BL/6 mice and enhanced the evolution of late MSV-induced disease in older mice.
D000367:Age Factors; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000276:immunology; D007372:Interferons / Q000276:immunology* / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008979:Moloney murine leukemia virus / Q000276:immunology; D012075:Remission, Spontaneous; D012756:Sheep / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007372:Interferons