A defect of the alternative pathway of complement.
The sera of patients defective at opsonization for yeast phagocytosis fix haemolytic complement poorly following incubation with the alternative pathway complement activators, inulin and bacterial endotoxin. This suggests that the defect lies early in the alternative pathway of complement.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000378:metabolism*; D004731:Endotoxins; D006801:Humans; D007223:Infant; D007444:Inulin; D008875:Middle Aged; D009895:Opsonin Proteins; D010587:Phagocytosis; D012441:Saccharomyces cerevisiae / Q000276:immunology
D004731:Endotoxins; D009895:Opsonin Proteins; D007444:Inulin; D003165:Complement System Proteins