Electronystagmographic study in rabbits on the vestibular effect of vincamine.
Vincamine (Vincapront), the alcaloid isolated from Vinca minor L, was tested in rabbits at three dosages (1 mg/kg, 5 mg/kg, 10 mg/kg i.m.) in an electronystagmographic study. The parameters evaluated were: duration, rate and frequency of the post-rotatory nystagmus and the frequency of the per-rotatory nystagmus. While the post-rotatory nystagmus was found to show a reduction in duration and rate, the frequencies did not respond to vincamine. The 1 mg/kg dose had the strongest effect while that of the 10 mg/kg dose was weakest. As these findings may not be explained by sedative or habituation effects we consider the reduction of the post-rotatory nystagmus as an analogue in animal experiments of the vestibular effect seen in man. The electronystagmographic pattern of action corresponds to that of some other antivertiginous drugs.
D000818:Animals; D004584:Electronystagmography; D005260:Female; D008297:Male; D009759:Nystagmus, Pathologic / Q000517:prevention & control; D011817:Rabbits; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000187:drug effects*; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014749:Vincamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D014748:Vinca Alkaloids; D014749:Vincamine