[Regulation of DNA replication (author's transl)].
Two aspects of the regulatory mechanisms of DNA replication are discussed: 1. When resting mammalian cells are stimulated to proliferate a genetic program is expressed which provides proteins and other replication factors; 2. the interaction of proteins with specific sections on the DNA leads to initiation; most probably, structural changes in chromatin are also involved. Once initiated, replication proceeds almost automatically through the elongation phase. Lymphocytes stimulated to proliferate by concanavalin A are used as an example to demonstrate the relative importance of the two aspects of DNA replication.
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D002843:Chromatin / Q000378:metabolism; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D008938:Mitosis; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D012313:RNA / Q000096:biosynthesis; D013997:Time Factors
D001426:Bacterial Proteins; D002843:Chromatin; D012313:RNA; D004259:DNA-Directed DNA Polymerase
Regulation der DNS-Replikation