[The action of levamisole on thymodependent rosettes in normal and atopic subjects].
Thymo-derived E-rosettes and fast E-rosettes have been determined in 26 normal and 17 atopic patients. The effect of levamisole in vitro has been studied by adjunction in the cell suspension at a concentration of 100 gamma/ml. In normal and atopic subjects the E-rosettes are not modified by levamisole. Fast E-rosettes are significantly increased by levamisole in normal but not in atopic patients. These results support the hypothesis of a functional deficiency of T-lymphocytes in atopy; they are correlated by the failure of treatment of atopic dermatitis by levamisole.
D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects*
D007978:Levamisole
Action in vitro du lévamisole sur les t-lymphocytes des sujets normaux et atopiques.