[T-lymphocytes and their function in Hodgkin's disease].
In untreated patients with Hodgkin's disease the percentage of T-lymphocytes was significantly reduced in comparison to healthy controls independent of the stage of the disease. The absolute number of T-lymphocytes was also reduced in most patients. The response of lymphocytes after PHA-stimulation was diminished parallel with the skin reactivity: Normal results were obtained in early stages and with favorable histological types whilst low values were found in stages III and IV and in unfavourable histological types. A correlation between the percentage of T-lymphocytes and the PHA-stimulation was found in early stages, but not in stages III and IV. There was also a correlation between the absolute number of T-lymphocytes and skin reactivity. The percentage of DNA-synthesizing lymphocytes was significantly higher than in normal blood. The highest values were found in stages III and IV and in unfavourable histological types. After radiation therapy the T-lymphopenia, the diminished PHA-stimulation as well as anergy was more pronounced than after chemotherapy.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002452:Cell Count; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006689:Hodgkin Disease / Q000097:blood / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D010835:Phytohemagglutinins
T-Lymphozyten und ihre Funktion beim M. Hodgkin.