title: Treatment of osteosarcoma.
abstract: Hippocrates has been credited with the statement 'for extreme diseases, extreme methods of care are most suitable'. This statement is very applicable to the disease osteosarcoma and especially to its treatment with high dose methotrexate. This paper will present the experience of the Department of Clinical Haematology and Oncology in the treatment of osteosarcoma with high dose methotrexate and summarize other groups' experiences with various chemotherapy regimes.
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy*; D012512:Sarcoma, Ewing / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate