title: LSD and 5-HTP: tolerance and cross-tolerance relationships.
abstract: Tolerance and cross-tolerance relationships between lysergic acid diethylamide (LSD) and 5-hydroxytryptophan (5-HTP) were studied in rats trained on an operant task. The results demonstrated that behavioral tolerance to both compounds occur in the rat and that asymmetrical cross-tolerance relationships exist; that is, animals tolerant to 5-HTP were cross-tolerant to LSD, but animals tolerant to LSD were not cross-tolerant to 5-HTP.
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D004361:Drug Tolerance; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D051381:Rats
chemical_list: D008238:Lysergic Acid Diethylamide; D006916:5-Hydroxytryptophan