title: Atypical fibroxanthoma of the skin. Presentation of 5 cases and a review of the literature.
abstract: A typical fibroxanthoma is a solitary tumour of the skin, which occurs mostly on sun-exposed areas in elderly people. The diagnosis can only be made with certainty on the typical histological findings, which suggest a bizarre malignant tumour. Although metastasizing tumours are reported in the literature, the authors believe that the true atypical fibroxanthoma is benign. Correct diagnosis obviates the need for unnecessary radical surgery. The possibility of atypical fibroxanthoma should always be considered when a histologically bizarre tumour is found on sun-damaged or irradiation-damaged skin in elderly patients or on previously traumatized sites. In this paper five cases are added to the 346 cases culled from the literature. Electron microscopic investigations in one case demonstrated cells with delicate cytoplasmic fibrils in small bundles. This does not necessarily suggest filaments of myofibroblasts, as has been previously reported.
mesh_terms: D000368:Aged; D005260:Female; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure