Release of gonadotrophin-releasing hormone (Gn-RH) from isolated, perifused medial-basal hypothalamus by melatonin.
Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1-10 mM) as 10-20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10-20 min pulses of melatonin (0.1-1.0 mM) consistently caused release of Gn-RH.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D007987:Gonadotropin-Releasing Hormone; D008550:Melatonin; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine