Lissamine green staining in the clinical diagnosis of xerophthalmia.
Lissamine green staining of the conjunctiva, a new and widely heralded aid for diagnosing early xerophthalmia, was found to be a reasonably specific but inadequately sensitive test for practical use. While 82% of clinically normal children failed to show staining, so did 57% with night blindness, 29% with vitamin A responsive Bitot's spots, and, most significantly, 26% with severe, vitamin A related corneal involvement. The test also failed to distinguish vitamin A responsive "Bitot's spots" from nonresponsive ones.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003318:Corneal Opacity / Q000175:diagnosis; D005260:Female; D006801:Humans; D008086:Lissamine Green Dyes; D008297:Male; D009755:Night Blindness / Q000175:diagnosis; D000644:Quaternary Ammonium Compounds; D012395:Rose Bengal; D014802:Vitamin A Deficiency / Q000175:diagnosis; D014985:Xerophthalmia / Q000175:diagnosis*
D008086:Lissamine Green Dyes; D000644:Quaternary Ammonium Compounds; D012395:Rose Bengal