PHA dose dependent defect in lymphocyte stimulation and E-rosette-forming cells in untreated Hodgkin's disease.
14 untreated patients with Hodgkin's disease were tested for lymphocte reactivity in vitro to optimal and suboptimal doses of PHA. A PHA dose-dependent defect in lymphocyte stimulation was demonstrated in patients when compared with a group of normal individuals. No correlation between the in vitro defect and decreased absolute number of E-rosette-forming cells (T-lymphocytes) in peripheral blood was found.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007158:Immunologic Techniques; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D037102:Lectins