Noxythiolin (Noxyflex), aprotinin (Trasylol) and peritoneal adhesion formation: an experimental study in the rat.
Clinical and experimental studies have suggested that noxythiolin and aprotinin may prevent intraperitoneal adhesion formation. A comparison was therefore made of their efficacy in preventing the reformation of adhesions following surgical lysis in a controlled trial using rats. Neither noxythiolon nor aprotinin had any significant benefit over surgical lysis alone. The mortality rate was high in the noxythiolin-treated group.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D008297:Male; D009677:Noxythiolin / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*; D000267:Tissue Adhesions
D009677:Noxythiolin; D007611:Aprotinin; D013890:Thiourea