Reactivity and crossreactivity of mouse helper T cells to malaria parasites.
The mouse helper T-cell response to four plasmodial and babesial parasites was measured by using them as carriers for a standard hapten (TNP). Helper T cells appeared to recognize all the parasites, but not to be able to distinguish between them. Helper T-cell responses could be augmented by vaccination with formalin-fixed parasites. However vaccination did not always confer protection against infection. Conversely, mice resistant to infection because of prior recovery from a homologous or heterologous infection had normal or reduced helper T-cell responses. It is concluded that resistance to infection with these parasites, though dependent on T cells, may not only involve the helper T-cell subpopulation.
D000818:Animals; D000918:Antibody Specificity; D000921:Antibody-Producing Cells; D003429:Cross Reactions; D006462:Hemolytic Plaque Technique; D008288:Malaria / Q000276:immunology*; D051379:Mice; D010961:Plasmodium / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination