Vestibulo-toxicity of tobramycin.
The case histories are described of two patients with normal renal function who developed permanent complete bilateral loss of peripheral vestibular function during tobramycin therapy. Despite the low incidence of the cochleotoxic and and vestibulotoxic side-effects of tobramycin, it seems advisable to monitor patients on tobramycin therapy for signs of vestibular dysfunction and hearing loss.
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007759:Labyrinth Diseases / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014031:Tobramycin / Q000009:adverse effects*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D014031:Tobramycin