Successful treatment of Candida endophthalmitis with a synergistic combination of amphotericin B and rifampin.
Candida endophthalmitis, caused by transient candidemia, developed in a 14-year-old white girl receiving intravenous hyperalimentation. Antifungal synergism was established in vitro for the combination of amphotericin B and rifampin against the C. albicans isolate. A combined ten-day course of intravenous amphotericin B and oral rifampin was followed by the elimination of the infection and the preservation of good visual acuity.
D000284:Administration, Oral; D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy*; D002404:Catheterization / Q000009:adverse effects; D009877:Endophthalmitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D014792:Visual Acuity
D000666:Amphotericin B; D012293:Rifampin