Electrographic and clinical effects of intracarotid sodium amobarbital on bilateral myoclonic status epilepticus.
The effects of rapid intracarotid injection of 20 to 100 mg of sodium amobarbital were studied in three patients with bilateral myoclonic status epilepticus due to Jakob-Creutzfeldt disease, sequelae to anoxic encephalopathy, and hepatic coma, respectively. In each instance, the drug produced prompt abatement of clonic jerks contralaterally and attenuation of electroencephalographic epileptiform discharges ipsilaterally. These results suggest that the cerebral cortex actively participates in the elaboration of certain types of bilateral myoclonus in human beings.
D000368:Aged; D000654:Amobarbital / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D002343:Carotid Artery, Internal; D002540:Cerebral Cortex / Q000187:drug effects; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications; D004569:Electroencephalography; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000188:drug therapy* / Q000209:etiology
D000654:Amobarbital