title: [Technical advances in demonstration of treponema-specific 19S-IgM antibodies in patients with latent or late-latent syphilis (author's transl)].
abstract: In patients with latent or late-latent syphilis as well as neurosyphilis the demonstration of treponema-specific 19S-IgM antibodies is not regularly possible. In this publication it is shown that high IgG antibodies are the reason for a competitive IgM inhibition in the indirect immunofluorescence tests. It is demonstrated that in the above mentioned states of the infection the IgM-FTA-19S test seemed to be the method of choice to realize the existence of 19S-IgM antibodies. In sera with competitive inhibited IgM it is possible to calculate the IgM antibody activity with the aid of the socalled F factor.
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D001667:Binding, Competitive; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M / Q000032:analysis; D009494:Neurosyphilis / Q000175:diagnosis; D013587:Syphilis / Q000276:immunology*; D013588:Syphilis Serodiagnosis; D014210:Treponema pallidum / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Zur Technik des Nachweises treponemenspezifischer 19S-IgM-Antikörper bei der latenten und spätlatenten Syphilis.