title: [Analgesic and anti-inflammatory efficacy of biarison. Clinical experimental studies (author's transl)].
abstract: The analgesic time-effect profile of 600 mg Biarison (clinical experimental number: RU 43-715) compared with 100 mg indometacin, placebo and a blank test was recorded for 12 healthy subjects as an intra-individual single-blind trial by means of electrical measurement of thresholds in the teeth. Biarison shows a powerful analgesic effect with a maximum increase of the threshold by 22.3 mA after 75 minutes. The maximum increase in mA with indometacin and placebo was 18 and 9 mA respectively. The differences are confirmed statistically. Under double blind conditions, no significant differences in antiphlogistic activity could be established between Biarison (900 mg/day) and indometacin (150 mg/day) with reference to the edema appearing after maxillary sinus operations.
mesh_terms: D000328:Adult; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011799:Quinazolines / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011799:Quinazolines; D007213:Indomethacin
vernacular_title: Analgetische und antiphlogistische Wirksamkeit von Biarison. Klinisch-experimentelle Untersuchungen.