In vitro effect of insulin on peripheral T-lymphocyte E-rosette function from normal and diabetic subjects.
Juvenile-onset diabetics (JOD) have a significantly low peripheral T-lymphocyte count. In vitro exposure of diabetic lymphocyte cultures to insulin causes a significant T-cells count increase and thereafter no significant difference is detectable among JOD, maturity-onset diabetics (MOD) and normal subjects (NS) T-cells counts. This finding supports the hypothesis that the T-lymphocyte depressed function present in JOD is a secondary phenomenon due to in vivo insulin deficiency. Possible mechanisms of insulin action in restoring E-rosette function are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
D007328:Insulin