title: Antibiotic prophylaxis of postoperative endophthalmitis.
abstract: Nonconcurrent analysis of 45,954 cataract operations performed by a single surgeon indicates that periocular injection of penicillin combined with multiple preoperative applications of topical chloramphenicol-sulphadimidine reduced the incidence of postoperative endophthalmitis by 72%. Periocular penicillin alone was ineffective. A concurrent masked randomized study of 6,618 cataract operations confirms the efficacy of combined prophylaxis and demonstrates that the topical regimen, by itself, is as ineffective as isolated penicillin prophylaxis.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002387:Cataract Extraction; D002701:Chloramphenicol / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000517:prevention & control*; D006801:Humans; D010400:Penicillin G / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods; D013418:Sulfamethazine / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013418:Sulfamethazine; D002701:Chloramphenicol; D010400:Penicillin G