The role of kallikrein in leukocyte migration inhibition.
Previous studies from this department have established the presence of leukocyte migration inhibition activity in acute nonimmune inflammatory rat pleural exudates, induced by different irritants, which involved coagulation phenomenon. In the present investigation we present evidence for a role of kallikrein in the leukocyte migration inhibition phenomenon exhibited by acute pleural exudate in rates depleted of kininogens by intravenous injection of cellulose sulfate.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D002464:Cell Migration Inhibition; D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D005174:Factor XII / Q000502:physiology; D005337:Fibrin / Q000494:pharmacology; D007610:Kallikreins / Q000502:physiology*; D007704:Kininogens / Q000502:physiology*; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D011288:Prekallikrein / Q000502:physiology; D051381:Rats; D013431:Sulfates / Q000494:pharmacology; D014361:Trypsin Inhibitors / Q000494:pharmacology
D007704:Kininogens; D013431:Sulfates; D014361:Trypsin Inhibitors; D005174:Factor XII; D005337:Fibrin; D002482:Cellulose; D011288:Prekallikrein; D007611:Aprotinin; D007610:Kallikreins