Vitamin C and post-suxamethonium pains.
A double-blind trial of the effects of vitamin C on the frequency, severity and duration of post-suxamethonium pains was performed. Fifty-three patients undergone bronchoscopy received either a placebo or 10 g of vitamin C. No beneficial effect was demonstrated. In 18 patients no relationship was found between pre-anaesthetic buffy layer vitamin C levels and the subsequent pains. Measurement of buffy layer and plasma vitamin C levels before and after anaesthesia did not suggest that vitamin C deficiency occurs during or immediately after administration of suxamethonium. It is concluded that the administration of vitamin C cannot be recommended as a means for prevention of suxamethonium pains.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001205:Ascorbic Acid / Q000097:blood / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D013390:Succinylcholine / Q000009:adverse effects*
D013390:Succinylcholine; D001205:Ascorbic Acid