Some immunological considerations relevant to the study of human bladder cancer.
The likelihood that immunosurveillance, concomitant immunity, and immunodepression play a role in the development and spread of neoplasms of the urinary bladder is discussed. The circumstantial evidence for the existence of concomitant immunity to bladder cancer-associated antigens is briefly reviewed, and the implications of the hypothesis of Zinkernagel and Dougherty of a genetic restriction to the cytotoxicity of T-cells for virally determined target cell antigens and of the concept of immunoregulatory cells for our understanding of the immunology of bladder carcinoma are discussed.
D000368:Aged; D000818:Animals; D000951:Antigens, Neoplasm; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D004137:Dinitrochlorobenzene; D004139:Dinitrofluorobenzene; D005796:Genes; D006084:Graft Rejection; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000235:genetics / Q000276:immunology*
D000951:Antigens, Neoplasm; D004137:Dinitrochlorobenzene; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D004139:Dinitrofluorobenzene