Effect of ultraviolet light on disease characteristics of NZB/W mice.
The development of antinuclear antiboides, proteinuria and cumulative mortality has been studied in four groups of NZB/W mice. Two groups were exposed to different amounts of ultraviolet light [UVL] and one group were bred and raised in total darkness. The fourth group served as a control. No significant difference was noted bwtween the groups in the development of antinuclear antibodies, proteinuria or in cumulative mortality. This study failed to show any major role of UVL as an environmental factor in the development of this disease.
D000818:Animals; D000974:Antibodies, Antinuclear; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000209:etiology*; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology; D011507:Proteinuria; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000974:Antibodies, Antinuclear