Immune responsiveness of irradiated mice reconstituted with complement receptor positive CLR+ or negative CLR--lymphocytes from spleen or bone marrow.
Spleen and bone marrow cells depleted of CRL cannot restore immune reactivity of irradiated mice to sheep red blood cells SRBC. The response to anti-SIII, a T-independent antigen does not change when irradiated animals are repopulated with spleen cells or spleen cells depleted of CRL. Spleen cells of 6-day-old mice having low number of CRL, in contrast to spleen cells of adult animals, could not reconstitute irradiated recipients.
D000367:Age Factors; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D001854:Bone Marrow Cells; D003176:Complement C3 / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D066298:In Vitro Techniques; D051379:Mice; D011951:Receptors, Complement / Q000276:immunology* / Q000528:radiation effects; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D003176:Complement C3; D011951:Receptors, Complement