Delayed hypersensitivity in the hamster cheek pouch.
A method is described for eliciting a delayed hypersensitive cell mediated immune response in the Syrian hamster cheek pouch. Using a sensitizing dose of 0.1% DNCB and a challenge dose of 0.01% DNCB 14 days later resulted in a histologically positive lymphocyte infiltrate in the challenge area. These results indicate that the hamster cheek pouch may not be an immunologically inert site and may be used for cell mediated immunity studies.
D000818:Animals; D000941:Antigens; D002610:Cheek / Q000276:immunology; D006224:Cricetinae; D004137:Dinitrochlorobenzene / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D007158:Immunologic Techniques; D009061:Mouth Mucosa / Q000276:immunology*; D009578:Nitrobenzenes / Q000276:immunology*
D000941:Antigens; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes