Effects o;f vitrectomy infusion solutions containing oxacillin, methicillin, or lincomycin.
Experiments conducted in rabbits showed no toxic effects on the retina by electroretinogram after vitrectomy when the infusion fluid contained as much as 50 microgram/ml of methicillin or lincomycin or 20 microgram/ml oxacillin. An abnormal electroretinogram was found in eyes receiving oxacillin in a concentration of 50 microgram/ml. Histologic studies showed ocular damage with concentrations of 50 microgram/ml of methicillin or lincomycin or 20 microgram/ml of oxacillin. All antibiotics were nontoxic to retina at 10 microgram/ml concentration, both by ERG and histology.
D000818:Animals; D004334:Drug Administration Schedule; D004596:Electroretinography; D009877:Endophthalmitis / Q000517:prevention & control*; D008034:Lincomycin / Q000009:adverse effects / Q000627:therapeutic use*; D008712:Methicillin / Q000009:adverse effects / Q000627:therapeutic use*; D010068:Oxacillin / Q000009:adverse effects / Q000627:therapeutic use*; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D014822:Vitreous Body / Q000601:surgery*
D008034:Lincomycin; D008712:Methicillin; D010068:Oxacillin