Haemophilus vaginalis (Corynebacterium vaginale) vaginitis in women attending public health clinics: response to treatment with ampicillin.
Haemophilus vaginalis (Corynebacterium vaginale) was isolated from genital specimens from 150 women who came to a public health venereal disease clinic. Forty-six patients returned to the clinic for at least one follow-up examination. Of the returnees, 22 of 24 who initially had received adequate therapy (14 g ampicillin in seven days) were cured, compared with three of 22 who did not received adequate therapy (X2 = 25.11; P less than 0.00005). These data included significant cure rates with adequate therapy among the 46 returnees, of whom 25 had vaginitis due to H. vaginalis only (X2 = 16.67;  P less than 0.00005) and 21 had vaginitis caused by a mixture of pathogens (X2 = 5.86; P less than 0.0156). Specimens obtained from 24 of the 46 returnees were cultured for H. vaginalis on the second visit; 19 were negative, and only five were positive. Clinical responses of the patients correlated closely with the results of culture in both treated and untreated groups (X2 = 14.23; P less than 0.00016).
D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use*; D002140:California; D003151:Community Health Centers; D003153:Community Health Services; D004305:Dose-Response Relationship, Drug; D005260:Female; D006194:Gardnerella vaginalis; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D007973:Leukorrhea / Q000188:drug therapy; D008875:Middle Aged; D014627:Vaginitis / Q000188:drug therapy*
D000667:Ampicillin