[Role of T- and B-cells in immunologic memory and the prolonged production of antibodies in the body].
The role of T and B cells in the immunological memory and prolonged antibody production in mice was studied; for this purpose CBA mice were immunized with SRBC in doses of 1 X 10(6) or 1 X 10(9) cells, decapitated 21--25 days later, and their spleen cells were treated with T or B antiserum and transferred in a dose 7 x 10(7) cells to syngeneic recipients treated with cyclophosphamide for suppressing their immunity. The treatment of the donor spleen cells with T or B antiserum resulted in a considerable decrease in the hemagglutinin level, as well as in the number of IgM- and IgG-forming cells. The transfer of T and B cells, mixed in equal amounts, to syngeneic recipients restored the immunological memory of the animals; in those cases when the mixture had the prevalence of T cells the restoration of the immunological memory was even more pronounced. The donor spleen cells treated with T or B antiserum, when tested for their ability to produce IgM- and IgG-forming cells in vitro (prior to their transfer to the recipient), showed a decrease in the production of IgM-forming cells (68%) and IgG-forming cells (74%) only under the action of B antiserum, whereas T antiserum had no influence on the production of IgM- and IgG-forming cells in vitro.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014185:Transplantation, Isogeneic
O roli T- i B-kletok pri immunologicheskoĭ pamiati i dlitel'noĭ produktsii antitel v organizme.