Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway.
Extensive unilateral or bilateral electrolytic ablation of the rat superior colliculus failed to reduce apomorphine- or amphetamine-induced rotation in animals with a unilateral 6-hydroxydopamine lesion of one nigro-striatal dopaminergic pathway. These findings suggest that a nigro-tectal pathway does not play a crucial role in mediating the circling response caused by striatal dopamine receptor stimulation. However, electrolytic lesions of the dorsal tegmental decussation reduced apomorphine- but not amphetamine-induced rotation in such animals, perhaps by sectioning some commissural pathway between the two nigro-striatal systems.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001519:Behavior / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D013477:Superior Colliculi / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D001058:Apomorphine; D003913:Dextroamphetamine; D004298:Dopamine