Effect of levamisole on autologous rosette-forming cells in nude mice.
Levamisole depresses the number of autologous rosette-forming cells (ARFC) in the spleen of nude (congenitally athymic) mice. Intravenous administration of 2.5 mg/kg of levamisole produces maximal depression. This effect appears 15 h after injection and is transient, partially disappearing after 48 hr. Dexamisole is devoid of this depressing activity. Thymopoietin, a thymic hormone, is also shown to lower the level of autologous rosette formation. These results suggest a stereospecific interference of levamisole with the maturation of immature T-cell precursors in a manner resembling the action of thymic hormones.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology; D013946:Thymopoietins / Q000494:pharmacology
D013946:Thymopoietins; D007978:Levamisole