Synthesis and pharmacological properties of some N-aroylhomotryptamines.
Eight amide compounds were obtained by condensation of appriopriate acid chlorides with homotryptamine and its 5-methoxyderivative. The effects of these compounds on the central nervous system were tested. m-Nitrobenzoylhomotryptamine showed the strongest sedative, anticonvulsive and analgesic properties.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014363:Tryptamines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000700:Analgesics; D000927:Anticonvulsants; D014363:Tryptamines; D006916:5-Hydroxytryptophan