[Effect of copolymers of N-vinylpyrrolidone and acrylic acid on individual stages of immunogenesis].
The analysis of NA-5 and NA-6, copolymers of acrylic acid and N-vinylpyrrolidone obtained by the method of radical copolymerization, indicated that these copolymers, while having no toxicity characteristic of polyacrylic acid known to be a powerful agent for stimulating immunogenesis, increased the migration of stem cells, and the processes of T and B lymphocyte spreading, as well as sharply enhanced the effect of interaction between T and B lymphocytes and partially replaced the helper function of T cells; all these actions finally enhanced immune response in the body. A decrease in the toxicity of copolymers was found to be in linear relationship with the percentage of the links of acrylic acid, whereas the adjuvant activity of the copolymers remained unchanged.
D000179:Acrylates / Q000494:pharmacology* / Q000633:toxicity; D000276:Adjuvants, Immunologic; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006824:Hybridization, Genetic; D007109:Immunity / Q000187:drug effects*; D008211:Lymphocyte Cooperation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011108:Polymers; D011205:Povidone / Q000494:pharmacology* / Q000633:toxicity; D013601:T-Lymphocytes / Q000187:drug effects
D000179:Acrylates; D000276:Adjuvants, Immunologic; D011108:Polymers; D011205:Povidone
Vliianie sopolimerov N-vinilpirrolidona i akrilovoĭ kisloty na otdel'nye étapy immunogeneza.