title: Gastrointestinal complication of high-dose corticosteroid therapy in acute cerebrovascular patients.
abstract: Corticosteroids are commonly used in the treatment of stroke, although their clinical effectiveness has not been established. Side effects, especially gastrointestinal complications, occur in patients with cerebral disease. A necroscopy study of 124 patients investigated the occurrence of gastrointestinal lesions in patients with acute stroke treated with high-dose of corticosteroids compared to untreated patients with stroke and to patients dying from non-vascular neurological diseases. A significant relationship between the use of steroids and gastrointestinal lesion in strokes is demonstrated.
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D003907:Dexamethasone / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000473:pathology; D013270:Stomach / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D003907:Dexamethasone