[Action of tetracyclines on the pseudotuberculosis microbe in vitro experiments and their effectiveness in experimental pseudotuberculosis in white mice].
227 out of 228 strains of pseudotuberculosis microbes studied in vitro proved to be sensitive to tetracyclines. The MIC of tetracycline and morphocycline ranged within 0.25--25 gamma/ml. The MIC of chlortetracycline and oxytetracycline was somewhat lower, i. e. 1--50 gamma/ml. When administered intramuscularly all the tetracyclines had pronounced therapeutic effect in experiments with albino mice infected with the antibiotic sensitive strains of J. pseudotuberculosis. Chlortetracycline proved to be the most active drug in treatment of albino mice per os.
D000818:Animals; D002751:Chlortetracycline / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D051379:Mice; D008826:Microbial Sensitivity Tests; D010118:Oxytetracycline / Q000627:therapeutic use; D013752:Tetracycline / Q000627:therapeutic use; D013754:Tetracyclines / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D015007:Yersinia / Q000187:drug effects*; D015009:Yersinia Infections / Q000188:drug therapy*; D015012:Yersinia pseudotuberculosis Infections / Q000188:drug therapy*
D013754:Tetracyclines; D013752:Tetracycline; D002751:Chlortetracycline; D010118:Oxytetracycline
Deĭstvie tetratsiklinov na psevdotuberkuleznyĭ mikrob v opytakh in vitro in ikh éffektivnost' pri éksperimental'nom psevdotuberkuleze belykh mysheĭ