Immunocytochemical localization of a gastric imhibitory polypeptide-like material within A-cells of the endocrine pancreas.
In rat pancreatic islets, the glucagon-producing A-cells also contain a GIP-like material as revealed by the peroxidase-antiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross-reactivity of anti-GIP with glucagon. It is concluded either that the A-cells synthesize a GIP-like peptide or that it is taken up from the circulation.
D000818:Animals; D000831:Animals, Newborn; D003429:Cross Reactions; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D007515:Islets of Langerhans / Q000166:cytology* / Q000378:metabolism; D051381:Rats
D005768:Gastrointestinal Hormones; D005749:Gastric Inhibitory Polypeptide; D005934:Glucagon