Importance of the spleen for the immuno-inhibitory aciton of linoleic acid in mice.
Certain immuno-inhibitory effects of a polyunsaturated fatty acid, linoleic acid (C18:2), no longer occur after splenectomy of young adult CBA mice. This observation suggest that the spleen is a major intermediary in the action of C18:2 on the lymphoreticular system. Pathways of this action remain to be elucidated. Possibilities include C18:2-stimulated suppressor cell generation in the spleen, or excess biosynthesis of immuno-inhibitory prostaglandins by splenic macrophages.
D000818:Animals; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D008041:Linoleic Acids / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology*; D013156:Splenectomy
D008041:Linoleic Acids