Gastrointestinal blood loss in man during administration of two ampicillin esters.
The gastrointestinal blood loss during intake of two ampicillin esters (pivampicillin and bacampicillin) was studied in 10 male volunteers. A radioactive chromium method was used. The study was performed with a double-blind cross-over technique. Pivampicillin seemed to give a slightly higher increase in gastrointestinal blood loss compared to placebo and bacampicillin but these bleedings are probably of no clinical significance.
D000328:Adult; D000667:Ampicillin / Q000009:adverse effects / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005243:Feces / Q000032:analysis; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010917:Pivampicillin / Q000009:adverse effects*; D010919:Placebos; D012107:Research Design
D010919:Placebos; D010917:Pivampicillin; D000667:Ampicillin