title: Preventing, detecting and managing adverse reactions of antihypertensive agents in the ambulant patient with essential hypertension.
abstract: The adverse reactions of antihypertensive agents are reviewed, including their clinical implications and suggested methods of preventing, detecting and managing them. The drugs discussed are: (1) diuretics--thiazides, furosemide, ethacrynic acid and spironolactone; (2) sympatholytics--reserpine, methyldopa, guanethidine, propranolol and clonidine; (3) vasodilators--hydralazine, prazosin and minoxidil. It is suggested that cooperative multi-disciplinary efforts should be undertaken to counteract the factors which contribute to improper use of antihypertensive agents.
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D001581:Benzothiadiazines; D003000:Clonidine / Q000009:adverse effects; D004232:Diuretics; D004347:Drug Interactions; D004976:Ethacrynic Acid / Q000009:adverse effects; D005665:Furosemide / Q000009:adverse effects; D006145:Guanethidine / Q000009:adverse effects; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy; D008750:Methyldopa / Q000009:adverse effects; D008914:Minoxidil / Q000009:adverse effects; D011224:Prazosin / Q000009:adverse effects; D011433:Propranolol / Q000009:adverse effects; D012110:Reserpine / Q000009:adverse effects; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D013148:Spironolactone / Q000009:adverse effects
chemical_list: D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006830:Hydralazine; D013148:Spironolactone; D008750:Methyldopa; D008914:Minoxidil; D005665:Furosemide; D012110:Reserpine; D011433:Propranolol; D004976:Ethacrynic Acid; D003000:Clonidine; D011224:Prazosin; D006145:Guanethidine