Cell-mediated hypersensitvity in glomerulonephritis.
Proportions and total numbers of peripheral blood T and B lymphocytes as well as their activity measured in the leukocyte migration inhibition test were estimated in 47 patients with acute or chronic glomerulonephritis and in 30 individuals serving as a control group. The obtained results indicated that glomerulonephritis was associated with altered proportions of peripheral blood lymphocytes. In acute glomerulonephritis high B lymphocyte levels were found while chronic proliferative glomerulonephritis was characterized by high proportions and high absolute levels of T lymphocytes. Few months observation of T: B lymphocyte proportions during the disease indicated that exacerbation of the disease was associated with lowered proportions of T lymphocytes. Moreover, it was shown that cell mediated hypersensitivity to GBM antigens was detectable in 80% patients with glomerulonephritis and was absent from patients with pyelonephritis. The latter results indicate participation of cell-mediated hypersensitivity in pathomechanisms of glomerulonephritis in most of the patients.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D002464:Cell Migration Inhibition; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*