title: Experimental studies of the potentiation of proguanil and pyrimethamine by dapsone using Plasmodium berghei in white mice.
abstract: An accurate system with stringent criteria has been established to test antimalarial drugs and drug combinations against Plasmodium berghei in mice. Minimum effective doses for a number of antimalarial drugs have been determined when used in this system. Considerable potentiation of the activity of pyrimethamine and to a somewhat less extent of proguanil by dapsone has been demonstrated. The need to extend studies of these combinations to the parasites of human malaria is discussed in terms of establishing a safe chemoprophylactic regime in the presence of drug-resistant strains of parasites.
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology; D003622:Dapsone / Q000494:pharmacology*; D004357:Drug Synergism; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects*; D002727:Proguanil / Q000494:pharmacology*; D011739:Pyrimethamine / Q000494:pharmacology*
chemical_list: D002738:Chloroquine; D003622:Dapsone; D002727:Proguanil; D011739:Pyrimethamine