Role of endotoxin contamination in ribiosomal vaccines prepared from Salmonella typhimurium.
Ribosomal vaccines prepared from Salmonella typhimurium SR-11 and 6707 an Re mutant bacterium of strain LT2, were effective immunogens in A/J and C3H/HeDub inbred mice. Only SR-11 ribosomes were able to induce significant protection in C3H/HeJ mice. C57BL/6J mice were not protected by either ribosomal preparation. A/J mice were protected against salmonella infection by purified SR-11 endotoxin preparations. Neither the C3H/HeDub, the C3H/HeJ, nor the C57BL/6J mice were protected by the endotoxin preparation. Passive hemagglutination studies showed that C3H/HeJ mice had no antibodies to O antigen but were significantly protected by SR-11 ribosomes. In contrast, C57BL/6J mice, which had the highest titers of O antibodies of the four inbred mouse strains, were not protected by SR-11 ribosomes. Endotoxin cannot totally  account for the effectiveness fo ribosomal account for the effectiveness of ribosomal vaccines prepared from S. typhimurium.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D004731:Endotoxins / Q000032:analysis; D006386:Hemagglutination Tests; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D012270:Ribosomes / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology* / Q000648:ultrastructure; D014612:Vaccines
D000907:Antibodies, Bacterial; D004731:Endotoxins; D014612:Vaccines