Haemopoietic progenitor-cell responses in mice with the transplanted lymphoid leukaemia ABE-8.
BALB/c mice bearing the transplanted lymphoid tumour ABE-8 developed increased levels of neutrophil, macrophage and eosinophil progenitor cells in the marrow and spleen. Neutrophil-macrophage progenitors, assayed as granulocyte-macrophage colony-forming cells in agar, increased in number only if invasion of the marrow or spleen by ABE-8 cells was demonstrable. Rises in B-lymphocyte colony-forming cells occurred whether or not there was invasion of the host spleen or marrow. No increase in progenitor cells was found in mice bearing diffusion chambers containing ABE-8 cells. The magnitude of leukaemic infiltration was determined by assaying numbers of leukaemic stem cells in the spleen and marrow using a selective cloning system. This transplanted lymphoid leukaemia appears to be a useful model for analysing the effects of haemopoietic tumours on host haemopoietic tissues.
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D001854:Bone Marrow Cells; D004804:Eosinophils / Q000502:physiology; D005260:Female; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007942:Leukemia, Experimental / Q000503:physiopathology; D007945:Leukemia, Lymphoid / Q000473:pathology / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000502:physiology; D013154:Spleen / Q000166:cytology