Ferritin immune complex deposits in the choroid plexus.
Mice injected intraperitoneally with 20 mg of ferritin twice weekly for more than 4 weeks developed proteinuria due to the deposition of ferritin-antiferritin antibody complexes in renal glomeruli. Deposits of ferritin, immunoglobulin G (IgG) and third complement component (C3) also accumulated in the perivascular, extracellular space of the choroid plexus as demonstrated by immunofluorescence and electron microscopy. The findings confirm previous observations on immune complex deposits in the choroid plexus in spontaneous autoimmune disease and persistent viral infections. The occurrence of similar deposits in the human choroid plexus and the possibility of an associated disturbance of the blood-spinal fluid barrier are discussed.
D000818:Animals; D000936:Antigen-Antibody Complex; D001812:Blood-Brain Barrier; D002831:Choroid Plexus / Q000032:analysis / Q000473:pathology*; D003176:Complement C3 / Q000032:analysis; D005110:Extracellular Space / Q000032:analysis; D005293:Ferritins; D005455:Fluorescent Antibody Technique; D007074:Immunoglobulin G / Q000032:analysis; D051379:Mice; D008854:Microscopy, Electron; D010539:Permeability
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G; D005293:Ferritins