title: A study of the action of valproic acid on the kindling effect.
abstract: The effect of an antiepileptic drug, valproic acid (VPA), on an experimental form of epilepsy, the kindling phenomenon, is described. In cat, 50 mg/kg i.p. per day is sufficient to block the progressive establishment of generalized seizures produced normally by repetitive electrical stimulation of the amygdala. However, a focal afterdischarge persists during the entire treatment. Higher doses (75-150 mg/kg) are necessary to protect the animal against the generalized tonic-clonic seizure when the kindling phenomenon is established. These effects and the action of barbiturates, which was also tested, seem to attribute to VPA a complex role in the mechanism of this action.
mesh_terms: D000679:Amygdala; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control*; D014631:Valerates / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D014631:Valerates; D014635:Valproic Acid; D010634:Phenobarbital