title: Effects of intravenous bolus dosages of methylprednisolone and local radiation on renal allograft rejection and patient mortality.
abstract: One hundred and thirty of 179 rejection episodes encountered in 205 transplants were reversed by treatment with a bolus preparation of methylprednisolone. Ninety-six of these episodes also required an increase in oral prednisone dosage. No beneficial effect on over-all graft survival was noted, but a significant rise in the mortality, secondary to sepsis, was noted in those who received more than 5 grams of methylprednisolone. Local radiation to the graft did not contribute to better graft survival or mortality.
mesh_terms: D003037:Cobalt Radioisotopes / Q000008:administration & dosage; D006084:Graft Rejection / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D007275:Injections, Intravenous; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology; D011878:Radiotherapy / Q000009:adverse effects; D014184:Transplantation, Homologous / Q000401:mortality
chemical_list: D003037:Cobalt Radioisotopes; D008775:Methylprednisolone