[Morphological changes in experimental infection in guinea pigs under the influence of prodigiozan and S-methylmethionine].
The effect of prodigiozan and S-methylmethionine on the level of histomorphological changes in the organs and tissues of guinea pigs with experimental typhoid fever, dysentery and staphylococcal infections, as well as the effect of prednizolone with respect to dysentery and staphylococcal infections were studied. In the control animals the highest histomorphological changes were observed on the 4th day after the infection in the liver, kidneys and spleen. In the animals with staphylococcal infection such changes were also observed in the lung tissue. In the animals treated with prodigiozan or S-methylmethionine in a dose of 20 mg or 0.3 ml of a 5 per cent solution respectively simultaneously with or 2 days after the infection the changes in the organs were less pronounced than those in the control. Under the effect of prednizolone used in a dose of 10 mg according to the same schedule the inflammatory-dystrophic changes in the internal organs of the animals with dysentery and staphylococcal infections were much higher as compared to the control.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D007239:Infections / Q000188:drug therapy*; D008070:Lipopolysaccharides / Q000627:therapeutic use*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012706:Serratia marcescens; D012764:Shigella sonnei; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy / Q000473:pathology
D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D008715:Methionine
Morfologicheskie izmeneniia pri éksperimental'noĭ infektsii u morskikh svinok pod vliianiem prodigiozana i S-metilmetionina.