[Tissue distribution of native and enzyme-treated human immunoglobulin (author's transl)].
The tissue distribution of intravenously injected native and enzyme-treated human gammaglobulin has been investigated in the small intestine, kidney, striated muscle and the salivary gland of the mouse. Peroxidase-as well as FITC-labeled antibodies to human gammaglobulin were used to locate the injected antibody preparation. With this assay, the enzyme-treated immunoglobulin was found intracellularly, whereas the intact molecule seemed not to penetrate the cell wall and could mostly be found intra-and perivascularly. Since highly purified tetanus toxoid was fixed by thin sections of the intestine tissue containing intracellularly located enzyme-treated gammaglobulin it is concluded that the antibodies penetrating the cell wall retain their biological activity.
D000818:Animals; D007136:Immunoglobulins / Q000378:metabolism*; D007158:Immunologic Techniques; D007421:Intestine, Small / Q000276:immunology; D007668:Kidney / Q000276:immunology; D008297:Male; D051379:Mice; D009132:Muscles / Q000276:immunology; D012469:Salivary Glands / Q000276:immunology
D007136:Immunoglobulins
Gewebeverteilung von nativem und enzymbehandeltem Human-Immunglobulin. Experimentelle Untersuchungen.