Studies on hyperlymphoid mice.
Injection of syngeneic, but chromosomally distinguishable, lymph node or spleen cells into adult mice resulted in both T- and B-lymphocyte chimaerism. In spleen-injected mice haematopoietic chimaerism was also established. It appeared that the donor T lymphocytes were added to the host recirculating T-cell pool so that a hyperlymphoid state was produced. The percentage of donor T lymphocytes declined very slowly in normal mice, but remained stable in adult-thymectomized animals. There was no evidence of a homeostatic mechanism involving destruction of excess peripheral T lymphocytes or grossly affecting the flow of T lymphocytes from the thymus into the recirculating T-cell pool. A preliminary model of the T-lymphocyte system is proposed.
D000818:Animals; D002678:Chimera; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000166:cytology; D017710:Lymphocyte Transfusion; D008218:Lymphocytosis / Q000276:immunology*; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D008938:Mitosis; D008954:Models, Biological; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D013934:Thymectomy; D013997:Time Factors; D014185:Transplantation, Isogeneic
D008934:Mitogens