title: Animal models in drug development: historical aspects.
abstract: The historical aspects of drug development and evaluation are anecdotically related. Clinical trials have proven the effectiveness of animal tests in the vast majority of cases, and the effort has been well spent. Similar of more noteworthy success may be obtainable with model systems in the study of prostatic cancer.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000266:history; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000266:history*; D049673:History, 20th Century; D009374:Neoplasms, Experimental / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents