The relationship of alpha1-antitrypsin to inflammatory periodontal disease.
Alpha1-antitrypsin (alpha1-AT) is a serum protease inhibitor with a well established role in bodily defense against destructive inflammatory diseases. alpha1-AT exhibits inheritable genetic polymorphism (Pi types). Certain Pi types have been shown to predispose to emphysema and, in this study, also appear to be related to increased chronic periodontitis susceptibility.
D000328:Adult; D000367:Age Factors; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood / Q000209:etiology* / Q000235:genetics; D010587:Phagocytosis; D010641:Phenotype; D011480:Protease Inhibitors; D011656:Pulmonary Emphysema / Q000209:etiology; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000502:physiology; D019896:alpha 1-Antitrypsin Deficiency
D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin