Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex.
Families have been HLA typed, and allotypes of the second component of complement and properdin factor B determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meioses was 14.39 at maximum likelihood estimate of the recombination fraction of .02. This is related to other estimates of the distance between these two genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics; D002648:Child; D002874:Chromosome Mapping; D003175:Complement C2 / Q000235:genetics*; D011415:Complement Factor B / Q000235:genetics; D003434:Crossing Over, Genetic; D005260:Female; D005796:Genes; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D010375:Pedigree; D012216:Rheumatic Diseases / Q000235:genetics
D003175:Complement C2; D006680:HLA Antigens; D011415:Complement Factor B