title: Nutrition and the immune response.
abstract: Vitamin E--selenium deficiency in dogs resulted in complete suppression of lymphocyte responsiveness to stimulation with mitogens. Depressing effects on neutralizing antibody synthesis were also noted. A serum factor associated with the inability of lymphocytes to respond has been isolated and partially purified. The suppressor factor can be removed or transformed by both in vivo and in vitro vitamin E supplementation.
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D004283:Dog Diseases / Q000276:immunology; D004285:Dogs / Q000276:immunology; D005333:Fetus / Q000276:immunology; D007109:Immunity; D007070:Immunoglobulin A / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis; D012643:Selenium / Q000172:deficiency; D013601:T-Lymphocytes / Q000276:immunology; D014804:Vitamin B Deficiency / Q000662:veterinary; D014811:Vitamin E Deficiency / Q000662:veterinary
chemical_list: D007070:Immunoglobulin A; D007073:Immunoglobulin E; D012643:Selenium