Cell membrane-mediated cytolysis by membranes from noncytolytic cells.
Cytolysis was obtained with plasma membrane fractions prepared not only from cytolytic T cells, but also from nonimmune lymphoid cells and, moreover, from cell lines of nonlymphoid origin displaying no lytic ability. Furthermore, no relationship exists between the genetic specificty of T cell-mediated cytolysis and the activity of membrane preparations. If anything, it appears that certain cell types may be unusually sensitive to membrane-mediated cytolysis. Our observations argue against a mechanistic relationship between T cell-mediated and membrane-mediated cytolysis.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology
D003208:Concanavalin A