[Two-phase respiration of apnoeic newborn, basic research and clinical value (author's transl)].
Studies on fetal human and calf lungs proved an 1: 2,5 increase rate of the transpulmonary blood-flow after inflation of the alveolar spaces. The extent of the inflation depends on the function pressure X time. Based on the rupture rate of the pulmonary tissue, the factor pressure is limited to 20-30 ch H2O. Consequently the inflation only can be obtained by increasing the factor time. Conditional on the flow resistance in the variably calibrated branches of the pulmonary system, the maximal pressure of 30 cm H2O has to act repeated continuously at least 10 seconds over an endotracheal tubus. Only then even the periphere alveoles will fully be inflated (phase I equals monotone inflation phase). An intermittend pressure breathing of maximal plus 30 cm H2O respectively-30 cm H2O will be supporting. After the total inflation short pressure waves of plus 30 cm H2O in physiological frequency (equals 30/minute) will do for further ventilation of the alveoles (phase II equals rhythmical ventilation phase).
D001238:Asphyxia Neonatorum / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D007384:Intermittent Positive-Pressure Breathing; D008168:Lung / Q000473:pathology; D011187:Posture; D011312:Pressure; D011652:Pulmonary Circulation; D012121:Respiration, Artificial / Q000379:methods*; D013997:Time Factors
Die Zweiphasenbeatmung des apnoischen Neugeborenen, experimentelle Grundlangen und klinischer Wert