title: [Reactogenicity and immunologic activity of live enteric Sonne dysentery vaccine from a spontaneous mutant].
abstract: Live dysentery Sonne vaccine from a spontaneous mutant proved to be practically areactogenic and specifically harmless in oral immunization of children aged from 7 to 13 years, in doses of from 3 to 25 milliard live microbial cells and in single and triple immunization schemes. Weak reactions of the gastro-intestinal tract were noted with the same frequency (1.7%) in children immunized with the vaccine and in children given placebo (2.2%). There proved to be a significant increase in the serum of the immunized persons of the level of specific hemagglutinins, and also of the IgA-and IgM-titers in 82% of the persons vaccinated; they persisted at a high level for 2 months. The appearance of IgA-antibodies in high titres in the persons vaccinated orally pointed to a marked local and general immunological activity of the live dysentery Sonne vaccine from the spontaneous mutant processing the capacity to survive in the intestine of children for a long time.
mesh_terms: D000293:Adolescent; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D004405:Dysentery, Bacillary / Q000276:immunology / Q000517:prevention & control*; D006388:Hemagglutinins / Q000096:biosynthesis; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D009031:Moscow; D009154:Mutation; D012764:Shigella sonnei / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated
chemical_list: D001428:Bacterial Vaccines; D006388:Hemagglutinins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014613:Vaccines, Attenuated
vernacular_title: Reaktogennost' i immunologicheskaia aktivnost' zhivoĭ énteral'noĭ dizenteriinoĭ vaktsiny zonne iz spontannogo mutanta