[The effect of proteinase inhibitor aprotinin on RNA-synthesis rate after partial hepatectomy in rats (author's transl)].
The effect of Aprotinin has been investigated on RNA-synthesis rate--measured by the incorporation of 3H-uridine--after partial hepatectomy in rats. In the control group two maxima of the incorporation of 3H-uridine into the regenerating liver were obtained after hepatectomy. On the other hand no increase of the 3H-uridine incorporation was detectable after Aprotinin pretreatment. The results indicate that Aprotinin inhibits the early events of liver regeneration by inhibition of proteinase enzymes.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D012313:RNA; D007611:Aprotinin
Der Einfluss des Proteinase-Inhibitors Aprotinin auf die RNS-Synthese nach partieller Hepatektomie bei Ratten.