Etiological, clinical and prognostic significance of the T-B immunological classification of primary acute lymphoid leukemias and non Hodgkin's lymphomas.
The discovery of B or T markers on neoplastic cells in acute lymphoid leukemia (ALL) is correlated with a poor prognosis, while a cure expectancy of 50% can be expected for null cell ALL patients of all ages. In the case of Non Hodgkin's malignant lymphoma the patients with the T cell types carry a poor prognosis, while the patients with a B cell type present an 85% cure expectancy, and those with the null cell type a 65% cure expectancy. The correlation between immune markers on the one hand, and WHO cyto-histological typing and clinical presentation on the other, is reported.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003176:Complement C3; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007223:Infant; D007945:Leukemia, Lymphoid / Q000145:classification* / Q000209:etiology / Q000276:immunology; D008223:Lymphoma / Q000145:classification* / Q000209:etiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell