[Control of the immunological reactivity in cervical cancer in the process of radiation therapy].
The author reports the results of studying 311 reactions of lymphocyte blasttransformation, 74 reactions of spontaneous rosette-formation and 186 reactions of plaque-formation in 184 patients with different stages of cervical cancer. It was found that in the tumor progression cell immunity indices are lowered and the degree of the lowering is dependent on the form of tumor growth. Radiotherapy results in the enhancement of autoantibody-formation processes and suppresses the response of lymphocytes to PHA found to be mostly pronounced in patients with advanced cancer. The blasttransformation reaction correlates well with the number of peripheral blood lymphocytes, and during radiotherapy the former slows down before the routinely revealed lymphopenia, that allows using this reaction to prognosticate lymphopenia. The most large amounts of plaque-forming blood cells were detected in patients with radiation injuries of the adjacent to the uterus organs of the small pelvis. Use of lymphocyte blasttrasformation reaction and quantitation of plaque-forming blood cells may provide the grounds for the individual application of radiotherapy for cervical cancer to increase its effectiveness.
D000937:Antigen-Antibody Reactions / Q000528:radiation effects*; D002278:Carcinoma in Situ / Q000276:immunology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000528:radiation effects; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000532:radiotherapy; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000528:radiation effects; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000532:radiotherapy
Kontrol' immunologicheskoĭ reaktivnosti bol'nykh rakom sheĭki matki v protsesse luchevoĭ terapii.