Specific suppressor cells in rats with neonatally induced transplantation tolerance.
The presence of suppressor cells was investigated in AVN rats bearing Lewis skin grafts of long standing after neonatal induction of transplantation tolerance. Pooled spleen cells from tolerant rats transferred to sublethally irradiated syngeneic recipients prolonged significantly and specifically the survival of skin allografts. Also, the factor present in the medium after cocultivation of lymphocytes from tolerant rats with Lewis antigens was effective.
D000818:Animals; D006085:Graft Survival; D006650:Histocompatibility Testing; D051381:Rats; D016038:Skin Transplantation; D013489:Suppression, Genetic; D013997:Time Factors; D014165:Transfer Factor / Q000302:isolation & purification; D014184:Transplantation, Homologous
D014165:Transfer Factor