T and B lymphocytes in patients with chronic active hepatitis (CAH).
Absolute numbers of T and B lymphocytes as well as active E rosette-forming cells were measured in twenty-seven patients with chronic active hepatitis (CAH), and in thirty control patients. In patients with CAH without cirrhosis, active E rosette-forming cells (a subpopulation of T lymphocytes considered to be actively involved in cell-mediated immune reactions) as well as lymphocytes with surface markers for IgA, IgM and IgG were increased. In patients with CAH and cirrhosis, total T lymphocytes were decreased. These results emphasize the significance of lymphocytes in CAH, and suggest the importance of monitoring T- and B-cell populations in patients with this disease.
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000150:complications / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008103:Liver Cirrhosis / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology