title: Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization.
abstract: Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D003714:Denervation; D005725:Ganglia, Autonomic / Q000166:cytology / Q000502:physiology*; D006321:Heart / Q000294:innervation*; D066298:In Vitro Techniques; D011894:Rana pipiens; D013569:Synapses / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology; D014630:Vagus Nerve / Q000187:drug effects*
chemical_list: D013779:Tetrodotoxin