IgM anti-IgM cold lymphocytotoxins to B cells.
Cytotoxic antibodies to B lymphocytes have been shown to be IgM. They are not absorbed by red blood cells and therefore not absorbed by red blood cells and therefore not directed against the I antigen of red cells. They are also not inhibited by mannose, as are certain natural cytotoxins against lymphocytes. Methods for producing purified eluates of IgM anti-IgM antibodies are given. These antibodies are postulated to be immunoregulative by acting on B lymphocytes.
D000042:Absorption; D000961:Antilymphocyte Serum / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D003080:Cold Temperature; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology; D012685:Sepharose; D012709:Serum Albumin / Q000276:immunology
D000961:Antilymphocyte Serum; D007048:I Blood-Group System; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012709:Serum Albumin; D012217:Rheumatoid Factor; D012685:Sepharose