Failure of immunogenic tumors to elicit cytolytic T cells in syngeneic hosts.
Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectromelia virus, to attack by similar cells from virus-immune, H-2 compatible mice. It is suggested that the failure to elicit cytolytic T cell production may be due to the lack of an appropriate association between tumour-specific antigens and elements of the major histocompatibility complex.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D003602:Cytotoxicity, Immunologic; D005354:Fibrosarcoma / Q000276:immunology; D006183:H-2 Antigens; D006968:Hypersensitivity, Delayed; D066298:In Vitro Techniques; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm; D006183:H-2 Antigens; D008748:Methylcholanthrene