title: [Immunological precursors of influenza epidemics].
abstract: The authors studied the immuno-epidemiological manifestations of ciculation and variability of the influenza virus during the periods preceding the officiallly recorded rise of the incidence of this disease. The following epidemic precursors were revealed: a) an increase of the number of persons who fell sick with subclinical form of the disease, accompanied by a rise in the population of the antibody level to the type of influenza virus whose latest variant later caused an epidemic morbidity elevation; b) a progressive predominance of the causative agent of the developing epidemic in the etiology of influenza; c) a growth of the collective immunity indices from the "minimal" to the "critical" levels; d) an increase of the sero-conversion multiplicity and of the antibody level in those who sustained the disease during the epidemic development. These precursors could be revealed at the period of from 1 1/2 to 6 months before the beginning of the morbidity growth caused by viruses of endogenous or of exogenous origin.
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000917:Antibody Formation; D004196:Disease Outbreaks; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology*; D009975:Orthomyxoviridae / Q000276:immunology; D013997:Time Factors; D014455:Ukraine
chemical_list: D000888:Antibodies, Anti-Idiotypic
vernacular_title: Immunologicheskie predvestniki épidemiĭ grippa.