Cross-reactive cytotoxic T cells to alphavirus infection.
Secondary Tc cells immune to alphaviruses (BEB, SIN and SFV) cross-react between serologically defined subgroups at the level of target lysis and at the level of induction of response. Despite this apparently complete Tc cell cross-reactivity between BEB, SIN and SFV, antisera raised against BEB and SIN showed virus specificity in their ability to block Tc cell-mediated lysis of alphavirus-infected targets. This result suggests that Tc cells recognize the same viral antigen molecule as antibodies, but with less specificity. Other possible interpretations are discussed.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001102:Arbovirus Infections / Q000276:immunology*; D001103:Arboviruses / Q000276:immunology; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000032:analysis; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007114:Immunization; D007156:Immunologic Memory; D051379:Mice; D008808:Mice, Inbred CBA; D012703:Serotyping; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D003165:Complement System Proteins