[Immunosuppression by means of cytostatic chemotherapy. Inhibition of antibody formation and induction of tolerance in animal experiments].
Two different experimental models are presented for the induction of immunosuppression and immunological tolerance in mice with antineoplastic drugs: a) an unspecific T cell activation with a phytomitogen (phytohemagglutinin), or b) a partial synchronization of antigen-induced proliferation by mitotic blockade with vincristinsulfate prepare lymphoid tissue for an increased sensitivity to cyclophosphamide. With the first model a complete (antigen-nonspecific) inhibition of antibody production--mediated by an inactivation of T cells which act synergistically with antibody-forming cell precursors during the induction of the humoral immune response ("helper cells") -- has been demonstrated. The second model was shown to be suitable for the induction of immunotolerance, indicating a rather selective suppression of a clone of antigen-specific cells.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D014750:Vincristine
Immunsuppression mit zytostatisch wirksamen Chemotherapeutika. Inhibition der Antikörper-Produktion und Toleranz-Induktion im Tierversuch.