Effect of TMP-SMX on nasopharyngeal carriage of ampicillin-sensitive and ampicillin-resistant hemophilus influenzae type B.
The carriage rate of ampicillin-resistant Hemophilus influenzae type B in a chronic care facility was investigated. Up to 48% of the children carried this strain. Of interest was the finding of simulaneous carriage of ampicillin-resistant and ampicillin-sensitive HITB, a phenomenon which was detected by using both chocolate agar and chocolate agar containing 2 microgram/ml of ampicillin. A trial of sulfamethoxazole-trimethoprin successfully eradicated the ampicillin-sensitive HITB, but had no effect on the ampicillin-resistant HITB.
D000667:Ampicillin / Q000494:pharmacology*; D004338:Drug Combinations; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D009305:Nasopharynx / Q000382:microbiology*; D010403:Penicillin Resistance; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D004338:Drug Combinations; D000667:Ampicillin; D014295:Trimethoprim; D013420:Sulfamethoxazole