[Rheologic, coagulative parameters and study of fibrinolysis in patients with coronary heart disease before and after aorto-coronary by-pass (author's transl)].
A study has been made of 31 patients with coronary heart disease where diagnosis had been clearly ascertained both from a clinical and strumental point of view. All patients had undergone aorto-coronary by-pass surgery. The controls of the parameters under observation (whole-blood and plasmatic viscosity, hematocrit, fibrinogen, euglobulin lysis, T protothrombin, T of partial thromboplastin, thromboelastogram antithrombin III, plasminogen, alfa2-macroglobulin and fractions C'3c, C'3c, C'4 of the complement) were carried out as follows: basic sample taken, I control (8th-10th day), II control (15th-20th day), III control (45th-50th day), IV control (85th-90th day) after surgical operation. A global examination of our results showed significant changes in the rheologic coagulative and fibrinolytic parameters after an aorto-coronary surgical operation. The slight tendency toward hypercoagulability met with in the basic blood sample (slight increase of whole-blood viscosity, hyperfibrinogenemy, inhibition of fibrinolytic activity) does not change significantly after surgical operation. This seems to indicate that the coronary by-pass does not in any way alter the evolution of arteriosclerosis.
D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D001783:Blood Flow Velocity; D001809:Blood Viscosity; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time
D003176:Complement C3; D003181:Complement C4; D005340:Fibrinogen
Parametri reologici, coagulativi e studio della fibrinolisi nei coronaropatici prima e dopo intervento di by-pass aorto-coronarico.