Quantitative in vitro phagocytic rate measurements.
A model for the calculation of phagocytic rate constants based on the assumption that the process of phagocytosis can be treated in a manner analogous to chemical reactions of the first order is suggested. By employing such an approach, accurate rate constants of ingestion of in vitro cultivated macrophages can be obtained following minimal time intervals from the onset of phagocytosis.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007700:Kinetics; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D012763:Shigella flexneri; D013696:Temperature; D013997:Time Factors