title: A preliminary controlled evaluation of the antihypertensive effect of indapamide.
abstract: A controlled, single-blind trial was carried out in 10 hypertensive patients to compare the effectiveness of a single daily dose (2.5 mg to 5 mg) of indapamide with that of placebo. Blood pressure was measured with a bias-free sphygmomanometer. Indapamide produced a significant reduction in mean systolic and diastolic pressures in both supine and erect positions. It was generally well tolerated: few side-effects were reported and no significant changes were noted in laboratory tests. It is concluded that further long-term studies of indapamide are indicated in larger numbers of patients.
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007190:Indapamide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D007190:Indapamide