title: Some aspects of the basic mechanisms of chemical carcinogenesis.
abstract: An extended summary is presented of current progress in research on the basic mechanism of chemical carcinogenesis conducted in the Division of Biophysics, School of Hygiene and Public Health, at the Johns Hopkins University. The first section concerns the involvement of free radicals in benzo[a]pyrene metabolism and carcinogenesis, the second the relationship between neoplastic transformation and somatic mutation, and the third the changes in DNA sequence organization and gene expression in neoplastic transformation.
mesh_terms: D000818:Animals; D001483:Base Sequence; D001580:Benzopyrenes / Q000378:metabolism / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D005609:Free Radicals; D005796:Genes; D006873:Hydroquinones / Q000378:metabolism; D066298:In Vitro Techniques; D009154:Mutation / Q000187:drug effects; D009369:Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D001580:Benzopyrenes; D005609:Free Radicals; D006873:Hydroquinones; D004247:DNA