The analgesic activity of imidazopyridine derivatives.
Analgesic and antipyretic activities of 2-(4-(2-imidazo-[1,2-a]pyridylphenyl)propionic acid (Y-9213) were studied with various experimental models. The analgesic activity of Y-9213 was found to be more potent than that of indometacin and morphine in the silver nitrate, Randall-Selitto, and phenylquinone writhing tests. Y-9213 also showed an analgesia in the tail pinch and electric stimulation test. On the warm water induced foot withdrawal reflex, Y-9213 was more effective in spinal-sectioned mice than in intact mice similarly to mephenesin and diazepam. Y-9213 was also proved to possess antipyretic activity as potent as indometacin and to be devoid of morphine-like property. Y-9213 exhibited little effect on the respiration and cardiovascular system in dogs. Y-9213 was found to be rapidly absorbed and eliminated from the blood with a half-life of about 2.5 h in rats. These findings indicate that Y-9213 may be an effective and well tolerated antipyretic and analgesic agent.
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001168:Arthritis / Q000139:chemically induced / Q000503:physiopathology; D003782:Dental Pulp / Q000187:drug effects; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000378:metabolism / Q000494:pharmacology*; D007977:Levallorphan / Q000494:pharmacology; D008297:Male; D051379:Mice; D011725:Pyridines / Q000378:metabolism / Q000494:pharmacology*; D011809:Quinones / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012835:Silver Nitrate / Q000494:pharmacology; D013116:Spinal Cord / Q000502:physiology
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D011725:Pyridines; D011809:Quinones; D007977:Levallorphan; D012835:Silver Nitrate