title: Carcinogenicity of trichloroethylene: fact or artifact?
abstract: Technical trichloroethylene has been found carcinogenic in mice after high daily doses per os. A GC-MS analysis of this technical sample revealed the presence of considerable amounts of epichlorohydrin and 1.2-epoxibutane as stabilizers. These epoxides are highly mutagenic in the Ames test and are, most probably, responsible for the carcinogenic effect found in mice. The question whether trichloroethylene is carcinogenic or not remains open.
mesh_terms: D002273:Carcinogens; D004340:Drug Contamination; D004353:Drug Evaluation, Preclinical; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects; D014241:Trichloroethylene / Q000032:analysis / Q000494:pharmacology*
chemical_list: D002273:Carcinogens; D009153:Mutagens; D014241:Trichloroethylene