title: Cooperativity of lectin binding to lymphocytes, and its relevance to mitogenic stimulation.
abstract: The relationship between the binding patterns of soybean agglutinin, peanut agglutinin (both in their native (unaggregated) form and in their polymerized form), and of Phaseolus vulgaris leucoagglutinin, to neuraminidase-treated lymphocytes from different sources, and the mitogenic activity of these lectins, was studied. In all cases investigated, binding of a lectin to lymphocytes which resulted in stimulation was a positive cooperative process. Our findings support the assumption that clustering of receptors and conformational changes in membrane structure are prerequisites for mitogenic stimulation.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D004351:Drug Resistance; D006854:Hydrocortisone / Q000494:pharmacology; D007700:Kinetics; D037102:Lectins; D008297:Male; D051379:Mice; D009439:Neuraminidase; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D037102:Lectins; D009439:Neuraminidase; D006854:Hydrocortisone