Platelet membrane glycoproteins in normal dogs and dogs with hemostatic defects.
Glycoproteins solubilized from membrane-enriched fractions of platelets from dogs with TT or VWD and from  normal controls were compared by SDS-PAGE. The results were similar to those for the analogous human disorders. Both normal and VWD canine platelet MPs contained three major glycoproteins as well as four smaller-molecular-weight proteins that stained for carbohydrate with the PAS  reagent. In contrast, MPs from dogs with TT had a higher concentration of GP I, a varied expression of GP II, and a lower concentration of GP III. The findings re-emphasize the value of comparative studies of these models of human hemostatic defects.
D000818:Animals; D001791:Blood Platelet Disorders / Q000097:blood / Q000473:pathology; D001792:Blood Platelets / Q000032:analysis* / Q000166:cytology; D002462:Cell Membrane / Q000032:analysis* / Q000502:physiology; D004285:Dogs; D006023:Glycoproteins / Q000032:analysis*; D014842:von Willebrand Diseases / Q000097:blood / Q000473:pathology
D006023:Glycoproteins