Mycophenolic acid for psoriasis.
Mycophenolic acid is an antimetabolite used experimentally for the treatment of psoriasis. Thirty-eight patients were treated with mycophenolic acid. A double-blind, placebo-controlled study demonstrated the efficacy of mycophenolic acid (P less than .01). A long-term safety study showed the occurrence of hematologic abnormalities, viral infections, and carcinoma. The position of mycophenolic acid in the therapeutic treatment of psoriasis must await the results of a multicenter cooperative study.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004825:Epiglottis; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*; D014777:Virus Diseases / Q000209:etiology
D009173:Mycophenolic Acid