title: Infectious lymphocytes in lymphocytic choriomeningitis virus carrier mice.
abstract: The infectivity of blood and lymphoid organs of mice persistently infected with lymphocytic choriomeningitis virus was found to be predominantly associated with lymphocytes and both T and B cells were infectious. A hypothesis is presented in which it is assumed that lymphocytes in carrier mice are infected via their LCM virus-specific antigen receptors, thereby leading to their antigen-triggered clonal expansion followed by infection and functional inactivation.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000382:microbiology; D001769:Blood / Q000382:microbiology; D002353:Carrier State / Q000382:microbiology*; D004195:Disease Models, Animal; D008214:Lymphocytes / Q000382:microbiology*; D008216:Lymphocytic Choriomeningitis / Q000382:microbiology*; D008217:Lymphocytic choriomeningitis virus / Q000472:pathogenicity*; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000382:microbiology; D013950:Thymus Gland / Q000166:cytology