Ultrastructural study of acute lymphocytic leukemia: comparison with immunologic studies.
Leukemic cells from 29 cases of acute lymphocytic leukemia (ALL), studied for T and B cell markers by the use of sheep erythrocyte rosetting and surface immunoglobulin determinations, were examined by electron microscopy. The majority of patients (76%) were found to have non-T, non-B neoplasms composed predominantly of relatively small, inactive-appearing cells with frequent nuclear folds. T cell cases (21%) were associated with mediastinal masses and were predominantly composed of large, active-appearing cells with nuclear irregularity and little rough endoplasmic reticulum. One case of B cell origin was not morphologically distinct from the non-T, non-B cell cases.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D011132:Polyribosomes / Q000648:ultrastructure; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000648:ultrastructure