Congenital stationary night blindness: an animal model.
Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave implict time. The dark-adapted ERG's consisted of a simple negative potential; the scotopic b-wave was nonrecordable. However, a normal c-wave was present in the dark-adapted response. Histologic studies demonstrated no structural abnormalities that could explain the functional defect.
D000222:Adaptation, Physiological; D000818:Animals; D003623:Dark Adaptation; D004195:Disease Models, Animal; D004596:Electroretinography; D005260:Female; D006734:Horse Diseases / Q000151:congenital*; D006736:Horses; D008027:Light; D008297:Male; D009755:Night Blindness / Q000151:congenital / Q000662:veterinary*; D012160:Retina / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure