Antibiotic metabolites from a marine pseudomonad.
An antibiotic-producing pseudomonad was isolated from a seawater sample from a La Jolla, Calif., tidepool. The pseudomonad produces two novel antibacterial compounds, 2-n-pentyl-4-quinolinol and 2-n-heptyl-4-quinolinol. It also synthesizes indole-3-carboxaldehyde, 6-bromoindole-3-carboxaldehyde, and the known antibiotic p-hydroxybenzaldehyde. Each of these compounds was identified by analysis of spectral data, and the structures were confirmed by synthesis or comparison with authentic samples.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001547:Benzaldehydes / Q000378:metabolism / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006912:Hydroxyquinolines / Q000378:metabolism / Q000494:pharmacology; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology; D011548:Pseudomonadaceae / Q000302:isolation & purification / Q000378:metabolism*; D012623:Seawater; D013211:Staphylococcus aureus / Q000187:drug effects; D014733:Vibrio / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001547:Benzaldehydes; D006912:Hydroxyquinolines; D007211:Indoles