Granulocyte transfusions in recovery of neutropenic rats from induced E. coli toxicemia.
Rats made transiently neutropenic by intra-arterial administration of vinblastine (3 mg/kg) and infected with E. coli (6.02+/-0.45 X 10(8), per animal) have a mortality rate of 90% within 48 h post infection. Multiple transfusions of large numbers of granulocytes (harvested from Deca-Durabolin treated donor rats) protected the neutropenic animals from sepsis. Out of a group of 11 rats, 10 recovered completely after repeated granulocyte transfusions.
D000380:Agranulocytosis / Q000150:complications*; D000818:Animals; D001803:Blood Transfusion; D004927:Escherichia coli Infections / Q000401:mortality / Q000628:therapy*; D005260:Female; D006098:Granulocytes; D007962:Leukocytes; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D051381:Rats; D014747:Vinblastine
D014747:Vinblastine