Cellular immune response in virus infections.
Two levels of specificity exist in the killing of virus infected target cells by immune effector T cells. One relates to the classic specificity for the virus, and the second involves the necessity for sharing expression of genes mapping in K and D but not I regions. Among the theories that could explain this is that of dual recognition with separate T-cell receptors detecting H-2 and viral antigen. Support for this possibility was provided by experimental influenza virus infection where evidence of specific recognition of viral products was obtained.
D000818:Animals; D001666:Binding Sites, Antibody; D003602:Cytotoxicity, Immunologic; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D051379:Mice; D009975:Orthomyxoviridae / Q000145:classification; D013601:T-Lymphocytes / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
D006649:Histocompatibility Antigens