Chlordiazepoxide-fluoxetine interactions on food intake in free-feeding rats.
Chlordiazepoxide, which blocks serotonin turnover, increased food intake; and fluoxetine, a serotonin agonist, decreased food intake. Administration of combinations of the two drugs showed an antagonistic dose-dependent relationship, implicating a satiety of hunger mechanims which is mediated by serotonin.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats
D011437:Propylamines; D005473:Fluoxetine; D002707:Chlordiazepoxide