T cell activation of primed rabbit blood lymphocytes by antigen.
Activation of primed rabbit PBL by homologous antigen in the early proliferative phase (on days 3--5) mainly involves lymphocytes which neither secrete specific antibody nor contain immunoglobulin in their cell membrane. This stimulation is antigen-specific, and evidence is given that the major proportion of these cells are T lymphocytes. The B cells forming Av-CHO-specific PFC were studied by autoradiography on days 6 and 12 of culture. Since incorporation of radioactive thymidine was found in the majority of PFC, these cells are also in proliferation.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002455:Cell Division; D008213:Lymphocyte Activation; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism
D000941:Antigens; D011947:Receptors, Antigen, B-Cell; D013936:Thymidine