title: [Use of ampicillin trihydrate in transplantation surgery].
abstract: Ampicillin trihydrate was used for the treatment of 29 patients with purulent inflammatory processes, such as peritonitis, suppurating operative wound, urinary tract infection after the kidney allotransplantation. The antibacterial activity of ampicillin was preliminarily tested on 517 microbial strains, i.e. staphylococci, streptococci, E. coli, Proteus and Ps. aeruginosa isolated from the surgical patients. The strains of penicillin sensitive staphylococci, streptococci and E. coli were most sensitive to the drug effect, the MIC ranging from 0.03 to 16 gamma/ml. It was shown that the blood retention time of the antibiotic was much more prolonged in the patients with a decreased excretion function of the kidneys. The treatment was performed under control of the clinical, bacteriological and biochemical parameters. The drug was used in a dose of 0.5 g 6--8 times a day for 5 to 15 days. A satisfactory therapeutic effect was registered in 73 per cent of the cases.
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use*; D001702:Biopharmaceutics; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D008826:Microbial Sensitivity Tests; D010538:Peritonitis / Q000188:drug therapy; D011182:Postoperative Care; D011183:Postoperative Complications / Q000188:drug therapy*; D013530:Surgical Wound Infection / Q000188:drug therapy; D013997:Time Factors; D014180:Transplantation / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000667:Ampicillin
vernacular_title: Primenenie ampitsillina-trigidrata v transplantatsionnoĭ khirurgii.