[Demonstration of the oncogenic activity of cell cultures using antithymocytic serum].
The authors examined 10 cell strains of different origin as to their effect on mice by means of antithymocytic (ATC) serum. In dependence on the strain used the tumors developed in different number and with different growth tendency. In control animals not treated by the ATC serum, small ganglions developed in some cases which, however, disappeared in 2--3 days. Both strains of diploide cells WI 38 and LEP and primary cultures of chicken fibroblast from embryos of SPF chickens did not develop any tumors. The antithymocytic serums from calfs were found to be less toxic for mice than the rabbit sera.
D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D002460:Cell Line; D046508:Culture Techniques; D006801:Humans; D007165:Immunosuppression Therapy; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000276:immunology; D012043:Regression, Psychology; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum
Nachweis der Tumorbildenden Aktivität von Zellkulturen durch Anwendung von Antithymozytenserum.