[D-penicillamin-induced IgA-deficiency (author's transl)].
A 6 year old girl developed IgA-deficiency following treatment for chronic hepatitis with D-penicillamine. 4 months after discontinuation of the drug serum IgA and the number of circulating B-lymphocytes were still markedly reduced, in addition secretory IgA was diminished relative to secretory IgM. D-penicillamine should be used only if absolutely necessary and during treatment frequent monitoring of immunoglobulin levels becomes mandatory.
D001402:B-Lymphocytes; D002648:Child; D002908:Chronic Disease; D004406:Dysgammaglobulinemia / Q000139:chemically induced*; D005260:Female; D006505:Hepatitis / Q000188:drug therapy; D006801:Humans; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007958:Leukocyte Count; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D010396:Penicillamine
D-Penicillamin-induzierter IgA-Mangel.