Genetic determination of the mitochondrial adenine nucleotide translocation system and its role in the eukaryotic cell.
On integrating experimental data published previously, the following picture of the mitochondrial adenine nucleotide (AdN) translocation system is being presented: 1. The AdN translocation system serves not only to transport ATP synthesized within mitochondria into the cytosol but also to transport cytosolic ATP into the mitochondria when oxidative phosphorylation is not functioning. 2. The AdN translocator is coded for by nuclear genes and the mitochondrial protein synthesis is not involved in its formation. 3. The AdN translocation system must be preserved and functioning even in cells which could dispense with oxidative phosphorylation. It assures appropriate concentrations of intramitochondrial ATP. 4. The intramitochondrial ATP is required for normal replication of mitochondrial DNA. Tis supports the view that the mitochondrion is a self-replicating semi-autonomous organelle. 5. The appropriate concentration of ATP must be present in mitochondria to make possible cell growth or multiplication. This points to a direct or indirect role of mitochondria in the control of cell proliferation.
D001692:Biological Transport; D001865:Bongkrekic Acid / Q000494:pharmacology; D004579:Electron Transport; D005796:Genes; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D008954:Models, Biological; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
D001865:Bongkrekic Acid; D000226:Mitochondrial ADP, ATP Translocases; D009713:Nucleotidyltransferases