Transfer of genetic information from T to B lymphocytes in the course of an immune response.
Lymphocytes carrying different allotypes were separated into B and T subpopulations and cultured in presence or in absence of U.V. inactivated Herpes simplex virus. The B lymphocytes cultured in presence of 1% of the supernatant collected from virus exposed T cells, synthesized an anti-herpetic antibody with some allotypic markers of the T cell donor.
D001402:B-Lymphocytes / Q000276:immunology*; D005111:Extrachromosomal Inheritance; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
D007126:Immunoglobulin Allotypes