[Newer antimycotics. III. Halogen- and nitro-substituted anilines and phenols (author's transl)].
The author produced a number of halogeno- and nitro-derivatives of anilines and phenols, investigated their antimicrobial efficiency in vitro, further the toxicity on mice of their most effective representatives. From the author's results it can be concluded that trihalogenoanilines and tetrachloroaniline exerted a relatively strong fungistatic activity with a broad spectrum of efficiency (Tab. 2) likewise to the polyhalogenophenols and halogenonitrophenols (Tab. 3). The acute toxicity of the most effective halogenoanilines was relatively small; they were found to be significantly less toxic than halogenophenols and tetramethyl-thiuramdisulfide (Tab. 5). On the basis of the intensive fungistatic activity and small toxicity of the tri- and tetrahalogenoanilines, it seems that a number of representatives of these types of chemical compounds could be given a role in the chemotherapy of superficial human and animal dermatomycoses, and also in the chemoprophylaxis of certain phytomycoses.
D000814:Aniline Compounds / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
D000814:Aniline Compounds; D000935:Antifungal Agents; D010636:Phenols
Neuere Antimycotika III. Halogen- und Nitro-substituierte Aniline und Phenole