The induction of TNP-altered, self-reactive human cytotoxic T cells by soluble factors: the role of Ia antigens.
This report demonstrates that human peripheral blood T lymphocytes, triggered by allogeneic cells or soluble antigens, elaborate helper factor(s) that promotes the in vitro differentiation of TNP altered-self reactive human CTL. Helper factor(s) alone is not sufficient for the generation of these killer cells, but requires the presence of TNP-derivatized autologous stimulators during sensitization. Additional experiments were performed with antisera to a human Ia-like antigen, p23, 30. These studies indicate that human Ia-like antigens play an important role in both the induction of helper factor(s) and in the functional activity of preformed helper factor(s) molecules.
D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007519:Isoantigens; D007700:Kinetics; D008285:Major Histocompatibility Complex; D009108:Mumps Vaccine / Q000276:immunology; D009578:Nitrobenzenes / Q000494:pharmacology*; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D014301:Trinitrobenzenes / Q000494:pharmacology*; D014373:Tuberculin / Q000276:immunology
D007519:Isoantigens; D009108:Mumps Vaccine; D009578:Nitrobenzenes; D013745:Tetanus Toxoid; D014301:Trinitrobenzenes; D014373:Tuberculin