Lack of DNA synthesis inhibitory activity in an immunosuppressor obtained from spleen.
A tissue extract derived from bovine spleen which is an immunosuppressor in vivo inhibits the incorporation of the two DNA pyrimidine nucleosides but does not inhibit the incorporation of purine nucleosides. The results indicate that the immunosuppressive action of the spleen extract is not mediated via inhibition of cell division.
D004247:DNA / Q000096:biosynthesis*; D003839:Deoxyadenosines / Q000378:metabolism; D003841:Deoxycytidine / Q000378:metabolism*; D003849:Deoxyguanosine / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007399:Interphase; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008938:Mitosis; D013154:Spleen; D013936:Thymidine / Q000378:metabolism*
D003839:Deoxyadenosines; D007166:Immunosuppressive Agents; D003841:Deoxycytidine; D004247:DNA; D003849:Deoxyguanosine; D013936:Thymidine