Regulation of antibody response in different immunoglobulin classes. VI. Selective suppression of IgE response by administration of antigen-conjugated muramylpeptides.
The suppressive effect of antigen-conjugated muramylpeptides or 6-O-mycoloyl muramylpeptides selectively on the induction of IgE antibody response was demonstrated. Preadministration of DNP-mycoloyl muramylpeptides completely inhibited the induction of the anti-DNP IgE antibody response with DNP-ovalbumin (DNP-OA). The selective suppression of the IgE response was due to the induction of DNP-specific suppressor T cells by DNP-mycoloyl muramylpeptides, and the suppressor cells were shown to be radiosensitive. Preadministration of OA-conjugated muramylpeptides partially inhibited the primary and secondary induction of an anti-OA IgE antibody response. The suppressor effect was also due to the induction of OA-specific suppressor T cells. Application of allergen-conjugated muramylpeptides as therapeutic agents in human allergic diseases was suggested.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D004136:Dinitrobenzenes / Q000276:immunology; D006020:Glycopeptides / Q000008:administration & dosage*; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009171:Mycolic Acids / Q000008:administration & dosage / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000941:Antigens; D004136:Dinitrobenzenes; D006020:Glycopeptides; D009171:Mycolic Acids; D007073:Immunoglobulin E; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D010047:Ovalbumin