Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide.
Splenic B cells C57BL/10ScCr mice fail to respond to the mitogenic principle of lipopolysaccharide (LPS), and do not express a serologically defined "LPS receptor". In contrast, polyclonal B cell responses to both purified protein derivative of tuberculin and lipoprotein are conserved.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D005796:Genes; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens; D009154:Mutation; D013154:Spleen / Q000276:immunology
D008070:Lipopolysaccharides; D008934:Mitogens