Hypersensititivity of rats to anorectic agents after lesions in the ventromedial hypothalamus.
Anorectic agents such as d-amphetamine and fenfluramine showed a remarkably higher effect in rats with hyperphagia after lesioning the ventromedial hypothalamus. A persistence and even a further increase of the hypersensitivity to anorectics was observed in animals which, eight months after ventromedial hypothalamus-lesioning, resumed almost normal eating patterns. The appearance of the hypersensitivity to anorectic agents after lesioning and its persistence or enhancement in long-term operated animals are interpreted in terms of the mechanisms contributing to the neural reorganization of the control of the feeding center after suppression of ventromedial inhibitory influences.
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D007031:Hypothalamus; D007033:Hypothalamus, Middle; D051381:Rats; D013238:Stereotaxic Techniques
D005277:Fenfluramine; D003913:Dextroamphetamine