T and B rosetting lymphocytes in the blood of smallpox patients.
The proportion of T and B cells in the peripheral blood of smallpox patients was determined. The average initial percentage of T cells was depressed (41 +/- 8.4%) in comparison with uninfected controls (65 +/- 7.6%), while the initial B cell counts averaged 26 +/- 11.4% and 28 +/- 5.1%, respectively. However, initial B cell percentages in four infected patients (two of whom died) were between 9 and 14, which are considerably lower than any control value, the lowest of which was 19%. Review of the literature emphasizes the both cellular and serological immunity play a role in recovery from pox disease; the two patients who had the highest initial nul cell (lymphocytes not identified as either T or B cells) counts died, while none of five patients who had consistently low nul cell counts died.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D008297:Male; D012899:Smallpox / Q000276:immunology*; D013601:T-Lymphocytes