Interaction of cytotoxic T lymphocytes with target cells. I. Specific inhibition by detergent-solubilized, partially purified mouse histocompatibility antigens.
H-2 antigens from EL4 (H-2b) and RLmale 1 (H-2d) leukemias were solubilized with deoxycholate and partially purified based on their adherence to a Lens culinaris hemagglutinin column. In double reciprocal experiments we have shown that these preparations specifically inhibit conjugate formation between target cells and alloimmune peritoneal lymphocytes, a preparation rich in cytotoxic T lymphocytes.
D000818:Animals; D001665:Binding Sites; D003602:Cytotoxicity, Immunologic; D003840:Deoxycholic Acid / Q000494:pharmacology*; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D007942:Leukemia, Experimental / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens; D003840:Deoxycholic Acid