Restricted heterogeneity of antibody synthesized by T-cell deprived mice.
Mice which had been thymectomized and injected with anti-thymocyte serum to remove long-lived recirculating T cells, initially failed to produce haemagglutinating and haemolysing antibody after injection of sheep erythrocytes. After six fortnightly injections of heterologous erythrocytes, however, haemolysin titres in the T-cell deprived mice were comparable to those in similarly challenged but immunologically intact animals. Isoelectric focusing of these sera indicated that the anti-sheep erythrocyte antibody eventually synthesized by the T-cell deprived mice was less heterogeneous than antibodies found in the sera of control mice.
D000818:Animals; D000910:Antibodies, Heterophile / Q000096:biosynthesis*; D000961:Antilymphocyte Serum / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D007525:Isoelectric Focusing; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy
D000910:Antibodies, Heterophile; D000961:Antilymphocyte Serum