Low density of Thy 1 antigen on mouse effector cells mediating natural cytotoxicity against tumor cells.
Mouse effector cells mediating natural cell-mediated cytotoxicity against tumor cells were found to contain a low density of Thy 1 antigen. Treatment of nude spleen cells, or spleen cells from mice in which natural reactivity was boosted, with anti-Thy 1.2 plus complement resulted in a substantial decrease in cytotoxicity. The spontaneous cytotoxic reactivity of young, thymus-bearing mice was resistant to such treatment, but repeated exposure to anti-Thy 1.2 plus complement did cause a decrease in lytic activity. By use of congenic anti-Thy 1.2 and effector cells from mice congenic for Thy 1, the effects of the treatment were shown to be specific for Thy 1.2 antigen.
D000818:Animals; D000961:Antilymphocyte Serum; D001665:Binding Sites; D002462:Cell Membrane / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D007141:Immunoglobulin Fc Fragments; D007519:Isoantigens