The effect of respiratory carcinogenesis on systemic humoral and cell-mediated immunity of Syrian golden hamsters.
The effect of intratracheal instillation of benzo(a)pyrene and its noncarcinogenic analog benzo(a)pyrene on the systemic humoral and cell-mediated immune response of Syrian golden hamsters was evaluated. Hamsters treated with the carcinogen had a transient suppression of the splenic plaque-forming cell response to sheep erythrocytes, compared with analog-treated controls. The numbers of direct (immunoglobulin M) and indirect (immunoglobulin G) plaque-forming cells were suppressed at the 9th week of treatment and then recovered to control levels. No suppression in the cell-mediated immune response, as assessed by the rejection of Chinese hamster skin grafts, was found.
D000818:Animals; D000917:Antibody Formation; D001580:Benzopyrenes / Q000008:administration & dosage / Q000494:pharmacology*; D006224:Cricetinae; D004912:Erythrocytes / Q000276:immunology; D006084:Graft Rejection; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced* / Q000276:immunology; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D001580:Benzopyrenes