Distribution of cardiac output in burned mice after treatment with triglycylvasopressin.
Earlier published results have shown an increased 5-day survival in burned mice treated with Triglycylvasopressin. In order to analyze the  cause of the increased survival, the distribution of cardiac output was studied in 51 mice divided into three groups. The investigation was performed on the 5th day after burn using a soluble indicator technique (86Rb). The first group consisted of unburned animals. In the second and third groups, a standardized burn of 15% of the body surface was undertaken. The animals in the second group were used as controls and received isotonic saline solution for 5 days. The third group were used as controls and received isotonic saline solution and in addition Triglycylvasopressin, a vasopressin with prolonged effect, 100 microgram/kg body weight subcutaneously twice a day in such a way that the total volume of fluid was identical in the different groups. Cardiac output distribution showed an increased fraction to kidney, liver and small bowel and a decreased fraction to carcass in the Triglycylvasopressin-treated animals compared to burned controls.
D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D002302:Cardiac Output / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D014667:Vasopressins / Q000031:analogs & derivatives*
D014667:Vasopressins; D008236:Lypressin