An arterio-venous study of serum alpha1-antitrypsin in patients with chronic bronchitis.
The effect of passage through the lung on alpha1-antitrypsin was studied in sixteen patients with chronic obstructive airways disease. The average mixed venous value of alpha1-antitrypsin (106.2% standard serum value) was not different from the the mean arterial value (105.6%). Where individual differences were found there was a similar difference in serum albumin. However, there was a small but significant rise (p less than 0.005) in serum alpha1-antitrypsin "complex" as blood traversed the lung (mixed value = 6.3%; mixed arterial value = 6.8%). The reason is not yet clear.
D001158:Arteries; D001991:Bronchitis / Q000097:blood*; D002908:Chronic Disease; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008168:Lung / Q000098:blood supply; D008173:Lung Diseases, Obstructive / Q000097:blood; D011652:Pulmonary Circulation; D014680:Veins; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D000515:alpha 1-Antitrypsin