[The relation between anti-hypertensive action and plasmatic concentration of pindolol. Preliminary study].
A correlation study between the antihypertensive effect and the plasma level of pindolol was performed in 10 patients with permanent essential hypertension. Pindolol was given orally (20 mg/day) during 9 days. The highly significant fall in blood pressure (delta SBP and delta DBP) is directly correlated negatively correlated, to the pretreatment pressure (p less than 0.02 for deltaSBP and p less than 0.05 deltaDBP) and negatively correlated to the pindolol plasma level (P less than 0.001 for delta SBP and p less than 0.05 for delta DBP). Multiple regression analysis shows, for delta SBP, a stronger influence of plasma level than of basal blood pressure. These results suggest that pindolol could have a specific effect in some hypertensive patients.
D000328:Adult; D000959:Antihypertensive Agents; D002986:Clinical Trials as Topic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D010919:Placebos
D000959:Antihypertensive Agents; D010919:Placebos; D010869:Pindolol
Relation entre l'action anti-hypertensive et la concentration plasmatique du pindolol. Etude préliminaire