title: Apparent cytotoxicity of base metal casting alloys.
abstract: The cytotoxic potentials of three Ni-Cr based alloys and an Fe-Cr based alloy were assessed. In tissue culture, casting of all four test materials and powders of the Fe-Cr based material did not elicit adverse cellular changes. However, cultures containing Ni-Cr powders showed prominent zones of lysis and cell alteration. The cytotoxic potential of products obtained from the surfaces of casting alloys may offer an expedient means for estimation of long-term clinical toxicity.
mesh_terms: D000818:Animals; D002857:Chromium / Q000009:adverse effects; D003300:Copper / Q000009:adverse effects; D003722:Dental Alloys / Q000009:adverse effects*; D003735:Dental Casting Technique / Q000009:adverse effects*; D005347:Fibroblasts / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D051379:Mice; D009532:Nickel / Q000009:adverse effects; D013499:Surface Properties
chemical_list: D003722:Dental Alloys; D002857:Chromium; D003300:Copper; D009532:Nickel