B-cell lymphoma lacking Fc- and C3d-receptors.
Various cell surface markers were studied in a patient with lymphosarcoma cell leukemia. The B-cell derived feature of the neoplastic cells could be identified by demonstration of monoclonal surface immunoglobulin of IgM-kappa type of high density synthesized by the cells. Interestingly, there were no Fc- nor C3d-receptors demonstrable using various techniques. Only 22% of the leukemic cells expressed C3b receptors. The failure of rosette formation with mouse erythrocytes was an additional surface feature distinguishing from ordinary chronic lymphatic leukemia of the B cell type. The phenotype of the leukemia cells is discussed as corresponding to that of a less differentiated B lymphocyte.
D001402:B-Lymphocytes / Q000032:analysis*; D001665:Binding Sites; D002454:Cell Differentiation; D002462:Cell Membrane / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007938:Leukemia / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007075:Immunoglobulin M