DNA-synthesizing T and non-T cells in chronic lymphocytic leukemia.
In 21 patients with chronic lymphocytic leukemia (CLL) and in 8 hematologically normal persons the number of DNA-synthesizing peripheral blood lymphocytes was investigated by autoradiographic techniques. The lymphocytes were differentiated by EN-rosette tests into T and non-T lymphoid cells. The results show a normal number of proliferating T lymphoid cells and an increased number of proliferating non-T lymphoid cells in clinical stages O-I. Stages III-IV demonstrate a significant increase of the proliferation rate of both T and non-T lymphoid cells. The possible pathogenetic factors and the prognostic value of these results are discussed.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000473:pathology
D004273:DNA, Neoplasm