[Influence of centrophenoxine on the effect of cyclophosphamide and chloramphenicol in teratological experiment].
Cyclophosphamide and chloramphenicol underwent a teralogical test in the animal experiment. The prenatal changes in the application of cyclophosphamide reveal the cytostatic remedy as a strong teratogenic remedy, whereas chloramphenicol in the first place has an embryotoxic effect and only a weak teratogenic one. The possibility of an influence on the prenatal changes caused by cyclophosphamide and chloramphenicol was tried with centrophenoxin. Apart from the weight of the foetuses the induced changes remained without influence in cyclophosphamide, whereas in chloramphenicol even in increase of the toxic effect could be observed.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D004357:Drug Synergism; D005260:Female; D005333:Fetus / Q000187:drug effects; D006016:Glycolates / Q000494:pharmacology*; D002504:Meclofenoxate / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013723:Teratogens
D006016:Glycolates; D013723:Teratogens; D002701:Chloramphenicol; D003520:Cyclophosphamide; D002504:Meclofenoxate
Der Einfluss des Zentrophenoxin auf die Wirkung von Zyklophosphamid und Chloramphenikol im teratologischen Experiment