title: The 1977 Bela Schick Memorial Lecture: disorders of suppressor cells in the pathogenesis of immunodeficiency, autoimmune and allergic diseases: human disease associated with disorders of an immunological breaking system.
abstract: A series of suppressor cell systems regulate virtually all immunological processes. Disorders of suppressor cells have been identified, including an increased number of activated suppressor T cells in some patients with hypogammaglobulinemia or with selective IgA deficiency. At the other end of the spectrum of immunological response a reduction in suppressor T cell activity has been implicated in the pathogenesis of autoimmune and possibly allergic diseases.
mesh_terms: D000361:Agammaglobulinemia / Q000209:etiology; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology; D007154:Immune System Diseases / Q000628:therapy; D007136:Immunoglobulins / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000276:immunology; D007167:Immunotherapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D007136:Immunoglobulins