title: [Effect of bificol on the intestinal microflora of chronic colitis patients working in antiboitic prodiction].
abstract: Data on the use of bificol, a new Soviet preparation, and its effect on the intestine microflora of patients with chronic colitis occupied in production of penicillin are presented. It was shown that by the 28th day of the preparation use the level of the intestine bacteria in the patients' intestine reliably increased. The number of immobile strains decreased from 67.6 to 36.6 per cent. Bifidoflora normalized by the 14th day of the treatment. Some clinical inprovement, i.e. stool normalization, lessening of the stomach pain, increased appetite were observed by the 4th--5th day of the treatment with bificol. On the basis of the microbiological and clinical data it was shown that treatment of the patients with chronic colitis in antibiotic production should continue for at least 28 days and in individual cases for longer periods of time. It is recommended to use the preparation in 10 doses a day divided into 2 parts.
mesh_terms: D000191:Actinomycetaceae / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001430:Bacteriocins / Q000627:therapeutic use*; D002908:Chronic Disease; D003092:Colitis / Q000188:drug therapy / Q000382:microbiology*; D004345:Drug Industry; D004781:Environmental Exposure; D004926:Escherichia coli / Q000302:isolation & purification; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007778:Lactobacillus; D009787:Occupational Medicine; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins
vernacular_title: Vliianie bifikola na mikrofloru kishechnika bol'nykh knronicheskim kolitom u usloviiakh proizvodstva antibiotikov