[Use of thymus hormone in the demonstration of acute T-null cell lymphocytic leukemia].
The Authors studied the effect of the human serum thymic factor on the peripheral-blood leukocytes from ALL patients, by testing the frequency of the E+cells by means of the e rosette assay before and after cell incubation with the above mentioned factor. In 3 out of 24 patients tested, the thymic factor incubation of peripheral-blood mononuclears increased the number of E+cells. The shift from R to E+cells caused by the human serum thymic factor occurred among null cells (E-, SM-Ig-). The possible value of the test in investigating whether a T0 leukemia might really exists is pointed out, as well as its prospective importance in monitoring the variations of the immature T cell counts in relationship to the patient's treatment and his disease course.
D000328:Adult; D002648:Child; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D013951:Thymus Hormones / Q000276:immunology*
D013951:Thymus Hormones
L'impiego dell'ormone timico nel riconoscimento della leucemia linfocitica acuta (LLA) a cellule T0.