The effect of diethylcarbamazine treatment on the development of bancroftian microfilariae in Culex p. fatigans.
Bancroftian microfilarie survived after one to three courses of diethylcarbamazine treatment in carriers and the larvae able to reach the infective stage in Culex p. fatigans. The infection rate and the development of infective larvae per infected mosquito from DEC-treated carriers was much lower than from the untreated carrier. The fact that surving MF can develop to infective stage in their vector indicates that such filarial carriers may be important sources for transmission of filariasis in the endemic areas after suspension of control measures.
D000293:Adolescent; D000328:Adult; D001769:Blood / Q000469:parasitology; D002353:Carrier State / Q000188:drug therapy / Q000469:parasitology; D003465:Culex / Q000469:parasitology*; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D005260:Female; D005368:Filariasis / Q000188:drug therapy* / Q000469:parasitology; D006801:Humans; D008297:Male; D014957:Wuchereria / Q000254:growth & development*; D014958:Wuchereria bancrofti / Q000254:growth & development*
D004049:Diethylcarbamazine