A mature T lymphocyte subpopulation marker closely linked to the Ig-1 allotype Ch locus.
An antiserum raised in BALB/c AnN mice against selected CAL.20 T cells reacts with a cell surface antigen in virgin animals that is found on 25% of mature thymocytes and Lyt-2-bearing T cells, but not on prothymocytes, Lyt-1 T cells or B cells. The antigen is restricted to strains carrying the Ig-1d or Ig-1e heavy chain allotype haplotypes. It is expressed in F1 mice. The antiserum blocks the binding of suppressor T cells to the cross-reacting idiotype for arsonate while reagents specific for Fab, Fc or Ig were ineffective. We suggest that the antigen described represents a determinant on the product of a new locus coding for a heavy chain-linked polypeptide found on a subpopulation of T cells.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D001853:Bone Marrow; D005260:Female; D006084:Graft Rejection; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007127:Immunoglobulin Constant Regions; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins; D051379:Mice; D013154:Spleen; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland
D000954:Antigens, Surface; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007127:Immunoglobulin Constant Regions; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins