Effect of mercurascan and tetracycline on ischaemia-altered immunogenicity of liver extract alloantigens in mice.
The action of Mercurascan and Tetracycline on ischaemic liver in mice was investigated. The effect was reflected in different immunogenicity (in allotrasplantation reaction) of liver extracts 1 mg. membrane fraction) derived from treated and normal organs in the donor--recipient strain combination B10--B10.LP. In the recipients treated with a single administration of extract from ischaemic liver the survival time of skin grafts was shortened as compared to the untreated control group and the control group given normal liver extract. Immunogenicity of the liver extracts from Mercurascan- or Tetracycline-treated mice was diminished.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005452:Fluoresceins / Q000494:pharmacology*; D007511:Ischemia / Q000276:immunology*; D007519:Isoantigens / Q000302:isolation & purification*; D008099:Liver / Q000098:blood supply; D008110:Liver Extracts / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009941:Organomercury Compounds / Q000494:pharmacology*; D016038:Skin Transplantation; D013752:Tetracycline / Q000494:pharmacology*; D014184:Transplantation, Homologous
D005452:Fluoresceins; D007519:Isoantigens; D008110:Liver Extracts; D009941:Organomercury Compounds; D013752:Tetracycline