title: Comparison of lidoflazine and quindine in prophylactic treatment of arrhythmias.
abstract: The efficacy of quinidine versus lidoflazine therapy was compared in the maintenance of sinus rhythm after electrical cardioversion for atrial flutter or fibrillation in a group of 35 patients. Both quinidine and lidoflazine were relatively ineffective in maintaining sinus rhythm after cardioversion. Lidoflazine was also used to prevent supraventricular and ventricular tachycardias in a miscellaneous group of patients; one of these with paroxysmal supraventricular tachycardia developed runs of venttricular tachycardia soon after starting lidoflazine. The trial was stopped after 4 patients died while receiving lidoflazine, on the suspicion that their deaths may have been related to drug-induced arrhythmias. The arrhythmogenic potential of lidoflazine when used in patients with supraventricular arrhythmias constrasts with reports of its apparent safety in large numbers of patients with angina pectoris.
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000517:prevention & control*; D001282:Atrial Flutter / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003645:Death, Sudden; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004554:Electric Countershock; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008013:Lidoflazine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011802:Quinidine / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011802:Quinidine; D008013:Lidoflazine