Dose response to fenoprofen in an antipyretic study of fenoprofen and propoxyphene.
Single oral doses of 0, 50, 100, and 200 mg (acid equivalents) of fenoprofen calcium provide essentially linear increases in antipyretic activity over a six-hour period in patients with fever due to acute upper respiratory tract infection. During this same time interval, 200 and 400 mg doses apparently had equal efficacy. Single oral doses of 200 and 400 mg propoxyphene napsylate had no significant effect on the fever of patients with acute respiratory tract infections. No significant interaction between propoxyphene and fenoprofen, related to the antipyretic effect of fenoprofen, was demonstrated.
D000284:Administration, Oral; D000700:Analgesics; D002986:Clinical Trials as Topic; D011431:Dextropropoxyphene / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004347:Drug Interactions; D005279:Fenoprofen / Q000008:administration & dosage / Q000494:pharmacology*; D005334:Fever / Q000188:drug therapy; D006801:Humans; D008297:Male; D010666:Phenylpropionates / Q000494:pharmacology*; D010919:Placebos; D012141:Respiratory Tract Infections / Q000188:drug therapy
D000700:Analgesics; D010666:Phenylpropionates; D010919:Placebos; D005279:Fenoprofen; D011431:Dextropropoxyphene