[Effect of long-term administration of testosterone on the activity of T- and B-lymphocytes in male rats].
Oil testosterone propionate solution was administered to Wistar rats for 14 days in a dose of 2 mg. Some rats were immunized with sheep red cells on the 10th day of the hormone administration. The animals were sacrificed on the 5th day of the immune response. The hormone proved to suppress considerably the blast lymphocyte response of the peripheral blood to PHA, but produced no influence in laconos stimulation. A sharp increase in the antibody forming cell count was noted in the spleen, whereas the rosette forming cell count had a tendency to reduction.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001402:B-Lymphocytes / Q000276:immunology*; D002452:Cell Count; D006728:Hormones / Q000008:administration & dosage; D007263:Infusions, Parenteral; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051381:Rats; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013739:Testosterone / Q000008:administration & dosage*; D013997:Time Factors
D006728:Hormones; D013739:Testosterone
Vliianie dlitel'nogo vvedeniia testosterona na aktivnost' T- i B-limfotsitarnykh sistem krys-samtsov.