Evidence for selective proliferation and histological localisation of B lymphocytes in the human tonsil.
Tonsil lymphocytes are labeled in vitro by 14C-thymidine and, respectively, 14C-uridine. The cells are separated by E-rosetting technique, and the fractions are characterised as B and T lymphocytes. Specific radioactivity was highest in the B lymphocytes, and large Lymphocytes are enriched in this fraction. The B lymphocytes are located in the germinal centres, the perinodular tissue contains T lymphocytes. The results indicate a selective proliferation of B lymphocytes in the germinal centres.
D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002250:Carbon Radioisotopes; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D014066:Palatine Tonsil / Q000166:cytology* / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D002250:Carbon Radioisotopes; D004247:DNA; D013936:Thymidine; D014529:Uridine