Inhibition of thiamine transport in Saccharomyces cerevisiae by thiamine disulfides.
Both thiamine disulfide and O-benzoyl thiamine disulfide, which are thiolfrom derivatives of thiamine, strongly inhibited thiamine transport in Saccharomyces cerevisiae. The inhibition appeared to be due to a high affinity of the analogs for yeast cell membranes, in which thiamine transport component(s) may be integrated.
D002462:Cell Membrane / Q000378:metabolism; D004220:Disulfides / Q000378:metabolism; D011745:Pyrithiamine / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013831:Thiamine / Q000031:analogs & derivatives* / Q000378:metabolism*
D004220:Disulfides; D011745:Pyrithiamine; D013831:Thiamine