Immunosuppression studies in foreign body tumorigenesis: no evidence for tumor-specific antigenicity.
Sarcomas were induced in CBA/H mice by sc implantation of 15 X 22 X 0.2-mm polyvinyl chloride vinyl acetate copolymer films. The animals were immunosuppressed with azathoprine, antilymphocyte globulin, or thymectomy. Sarcoma development was not accelerated in comparison to nonimmunosuppressed demonstrated in sarcomas of immunosuppressed mice. It was concluded that foreign body tumorigenesis in mice in neither associated with nor dependent on the emergence of tumor-specific transplantation antigens.
D000818:Animals; D000831:Animals, Newborn; D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum; D001379:Azathioprine / Q000494:pharmacology; D005260:Female; D005549:Foreign-Body Reaction / Q000276:immunology*; D006649:Histocompatibility Antigens; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010969:Plastics; D012513:Sarcoma, Experimental / Q000209:etiology / Q000276:immunology*; D012737:Sex Factors; D013950:Thymus Gland / Q000276:immunology
D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens; D010969:Plastics; D001379:Azathioprine