Sulphonamides in the treatment of acute Escherichia coli infection of the urinary tract in women. Clinical and ecological effects of sulphasomidine and sulphalene.
28 non-pregnant women were treated with conventional doses of sulphasomidine or sulphalene for acute urinary tract infections caused by Escherichia coli. Both preparations were found to be effective in simple cystitis infection with sulphonamide-sensitive organisms. Also, both were found to exert a selective pressure favouring sulphonamide-resistant E. coli in the faecal flora.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003556:Cystitis / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy; D013415:Sulfalene / Q000008:administration & dosage / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000008:administration & dosage / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D013424:Sulfanilamides; D013415:Sulfalene