Macrophage migration inhibitory factor in rheumatoid pericarditis.
The pericardial effusion in a case of rheumatoid pericarditis was studied to determine whether immune complexes and mediators of cellular immunity, represented by migration inhibitory factor (MIF), were present. MIF-like activity was detected in the pericardial fluid, but only traces of immune complexes were revealed by ultracentrifugation. The MIF-like activity was partially characterized by column fractionation and sugar inhibition tests. The role of lymphokines in the pathogenesis of this case of rheumatoid pericarditis is strongly suggested.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors; D008264:Macrophages / Q000276:immunology*; D008722:Methods; D010490:Pericardial Effusion / Q000276:immunology*; D010493:Pericarditis / Q000209:etiology / Q000276:immunology*
D008263:Macrophage Migration-Inhibitory Factors