[Physiopathogenesis of idiopathic hairy virilism. I. Peculiarities of the metabolism of androgens in idiopathic hairy virilism and general physiopathogenesis].
In most cases the persistent rise in the level of production of testosterone associated with a lowering of transport protein leads to the presence of free testosterone at a threshold level, which in turn brings into play irreversibly 5 alpha reductase that is potentially present in every woman in the areas where male characteristics are to be found. As a result the production is associated with a primitive drop in transport protein or with an excess of change of androstenedione into testosterone in the pilosebaceous follicle itself. This can be primary or secondary to a leveling out of the production of testosterone. This rise in production of testosterone comes about because of the summation of a rise of its glandular secretion and rise in both hepatic and peripheral conversion of androstenedione into testosterone, an absolute value (a rise in its production) and not a relative value (a diminution of the coefficient of transformation).
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000502:physiology; D015113:Androstane-3,17-diol / Q000652:urine; D000735:Androstenedione / Q000378:metabolism*; D002352:Carrier Proteins; D013196:Dihydrotestosterone / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D011944:Receptors, Androgen / Q000502:physiology; D013737:Testis / Q000503:physiopathology*; D013739:Testosterone / Q000096:biosynthesis*; D014770:Virilism / Q000503:physiopathology*
D002352:Carrier Proteins; D011944:Receptors, Androgen; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D000735:Androstenedione; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Physiopathogénie du virilisme pilaire idiopathique. I. Particarités du métabolisme des androgènes dans le virilisme pilaire idiopathique et physiopathogénie d'ensemble.