Infectious agents in immunodeficient murine models: pathogenicity of Actinomyces israelii serotype I in congenitally athymic (nude) mice.
Nude (Nu/Nu) and heterozygous (NU/+) mice were infected with Actinomyces israelii serotype I by either intranasal instillation or intravenous injection. Lung clearance data and 50% lethal dose values indicated that T-lymphocytes were not necessary for pulmonary clearance or prevention of systemic actinomycosis. However, T-lymphocyte deficiency may play a role in the localized cervicofacial form of actinomycosis.
D000190:Actinomyces / Q000276:immunology; D000196:Actinomycosis / Q000276:immunology*; D000818:Animals; D005145:Face; D007113:Immunity, Innate; D008168:Lung / Q000382:microbiology; D051379:Mice; D008819:Mice, Nude / Q000276:immunology* / Q000382:microbiology; D009333:Neck; D012703:Serotyping; D013601:T-Lymphocytes / Q000276:immunology