title: Role of subdermal current shunts in the failure of frogs to regenerate.
abstract: Large, uniform, skin-driven currents (20-40 muamp/cm2) leave the ends of limb stumps of post-metamorphic frogs (Rana pipiens) from about the first through the tenth day after amputation. However, right after amputation, while currents of comparable density may leave the periphery of the cut surface, current densities are greatly depressed in the center of this surface. We suggest that this depression is brought about by shunting through the subdermal lymph space (characteristic of anurans but not urodeles); continues in covert form after formation of a wound epithelium; and helps explain the ability of small, imposed currents to initiate frog limb regeneration.
mesh_terms: D000200:Action Potentials; D000818:Animals; D001001:Anura; D006614:Hindlimb / Q000502:physiology; D008208:Lymphatic System / Q000502:physiology; D011894:Rana pipiens / Q000502:physiology*; D012038:Regeneration; D012879:Skin Physiological Phenomena; D014945:Wound Healing