Use of platelet-fibrinogen-thrombin mixture to seal experimental penetrating corneal wounds.
A platelet-fibrinogen-thrombin mixture utilizing autologous platelets was studied for its potential to seal perforating corneal wounds. In rabbits, the mixture demonstrated sufficient adhesive properties to permit 75% of penetrating keratoplasties to remain in place without the use of sutures. All 12 grafts held initially; after 48 h three grafts extruded. In control eyes only two out of 12 (16%) of the corneal grafts remained in place. The material is simple to prepare and apply and is not toxic to the cornea. It does not cause inflammation or lid irritation. Intraocular complications observed with its use were transient anterior synechiae and retrocorneal membrane formation.
D000818:Animals; D001792:Blood Platelets; D065306:Corneal Injuries; D004338:Drug Combinations; D005131:Eye Injuries / Q000628:therapy*; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives
D004338:Drug Combinations; D014014:Tissue Adhesives; D005340:Fibrinogen; D013917:Thrombin