The absence of a human thymus lymphocyte antigen (HTLA) on bosophils and mast cells.
Basophilic granulocytes and mast cells of different species have been reported to originate from thymocytes and other lymphocytes. These observations were recently confirmed when evidence was given that thymic antigen is present on rabbit basophilic granulocytes. In the study reported here, human leukocytes were tested by the immunofluorescence technique and the immunoelectron-microscopy technique to ascertain whether a human thymus lymphocyte antigen (HTLA) could be detected on their surface. We could demonstrate the presence of HTLA on T lymphocytes but not on basophilic granulocytes, nor on mast cells in Cryostat sections of various tissues.
D000234:Adenoids / Q000276:immunology; D000918:Antibody Specificity; D000941:Antigens; D001491:Basophils / Q000276:immunology* / Q000648:ultrastructure; D001980:Bronchi / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D008407:Mast Cells / Q000276:immunology* / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure
D000941:Antigens