title: Mutagenicity for Salmonella typhimurium of urine obtained from humans receiving nitrofurantoin.
abstract: Urine samples from 12 humans receiving oral therapeutic doses of nitrofurantoin were mutagenic for Salmonella typhimurium strain TA 100 and nonmutagenic for strain TA 100-FR1. Mutagenic activity of the urine was not increased by treatment with beta-glucuronidase. Spot mutation assay of the chromatogram of urine revealed that the mutagenic activity of the urine was mainly due to unmetabolized nitrofurantoin.
mesh_terms: D006801:Humans; D009153:Mutagens; D009154:Mutation / Q000187:drug effects; D009582:Nitrofurantoin / Q000009:adverse effects / Q000494:pharmacology* / Q000652:urine; D012486:Salmonella typhimurium / Q000187:drug effects*
chemical_list: D009153:Mutagens; D009582:Nitrofurantoin