Subpopulations of human T lymphocytes. VIII. Locomotion of lymphocyte subpopulations in patients with primary immunodeficiency disorders.
Peripheral blood T and non-T lymphoid cells were examined in 31 patients with a variety of primary immmunodeficiencies for their locomotor activity toward casein and endotoxin-activated serum. T cells from 1 and non-T cells from 2 of 7 patients with Bruton type agammaglobulinemia had poor locomotor activity in this system. Both T and non-T lymphoid cells from all patients with common variable immunodeficiency disease had normal locomotor response to casein and EAS. Heterogeneity in locomotor abnormaltiy of T and non-T cells toward casein and endotoxin-activated serum was observed in other immunodeficient patients. No direct correlation was observed between the proportion of cells in the several T cell subsets and the abnormalities of locomotion of T cells.
D000361:Agammaglobulinemia / Q000276:immunology; D001260:Ataxia Telangiectasia / Q000276:immunology; D002465:Cell Movement; D004062:DiGeorge Syndrome / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000276:immunology; D006801:Humans; D017098:IgA Deficiency; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007244:Infectious Mononucleosis / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification*; D013945:Thymoma / Q000276:immunology