title: Effect of an inhibitor of pepsin proteolytic activity in the Exalto-Mann-Williamson ulcer.
abstract: The role of pepsin proteolytic activity in the Exalto-Mann-Williamson ulcer has previously not been established. Our studies show that a potent inhibitor of pepsin activity, when administered orally to E-M-W dogs, reduced both the incidence and severity of jejunal ulceration. These results indicate that pepsin may play a major role in the development of ulceration in this model.
mesh_terms: D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006400:Hematocrit; D006452:Hemoglobinometry; D008031:Lignin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010434:Pepsin A / Q000037:antagonists & inhibitors* / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D013276:Stomach Ulcer / Q000097:blood / Q000201:enzymology* / Q000517:prevention & control
chemical_list: D011506:Proteins; D008031:Lignin; D010434:Pepsin A