Suppression of the secondary immune response by specific antibody, when given together with the secondary antigenic stimulus.
It is generally believed that antibody-mediated immunosuppression can be only produced in non-primed individuals, and that this applies both to experimental animals and Rh-negative women at risk. However, in this paper it is reported that the additional injection of 0.2 ml of an antiserum to sheep erythrocytes (SE) together with a secondary antigenic stimulus of 10(8) SE into mice, primarily immunized by a tiny dose of 5 x 10(5) SE 28 days before, was capable of producing effective suppression of the secondary immune response.
D000818:Animals; D000918:Antibody Specificity; D000941:Antigens; D005260:Female; D006462:Hemolytic Plaque Technique; D007156:Immunologic Memory
D000941:Antigens