title: Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin.
abstract: A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.
mesh_terms: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D003429:Cross Reactions; D009500:Neutralization Tests; D012762:Shigella dysenteriae / Q000276:immunology; D012763:Shigella flexneri / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins