title: B and T lymphocytes in cerebrospinal fluid and blood in multiple sclerosis, optic neuritis and mumps meningitis.
abstract: B and T cells were defined in cerebrospinal fluid (CSF) and blood of 18 multiple sclerosis (MS), five optic neuritis, and 17 mumps meningitis patients by counting immunoglobulin-bearing lymphocytes for B cells, and the capacity of rosette formation with sheep erythrocytes of T-cell determination. Patients with MS and mumps meningitis had significantly higher T-cell values in CSF compared to blood, while the B cell value was significantly lower in CSF in mumps meningitis only. MS patients also displayed significantly lower B-cell values in blood compared to mumps meningitis patients and blood donors. No significant differences were observed between MS patients in exacerbation and in remission.
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000276:immunology*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D009107:Mumps / Q000134:cerebrospinal fluid / Q000276:immunology*; D009902:Optic Neuritis / Q000134:cerebrospinal fluid / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology