Biliary colic as a model for assessing analgesic activity in man.
Acute pain from biliary colic is a model of pathological pain suitable for pharmacological investigations. It has been found useful for assaying analgesic effect of a narcotic-type agent (pentazocine) and a non-narcotic drug (indoprofen), both given intravenously in a single dose. Differences in pain intensity scores assessed on a five-point scale were taken as measurement of the pain-relieving effect. Distribution-free methods were used to estimate the potency ratio of the tested drugs. The analgesic potency of indoprofen based both on total and peak effect was roughly one-tenth that of pentazocine on a weight-for-weight basis. No adverse reactions were associated with indoprofen and a few were found after pentazocine.
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001660:Biliary Tract Diseases / Q000503:physiopathology*; D002986:Clinical Trials as Topic; D003085:Colic / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use; D007275:Injections, Intravenous; D008297:Male; D008722:Methods; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000008:administration & dosage / Q000627:therapeutic use*; D010666:Phenylpropionates / Q000008:administration & dosage / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D010666:Phenylpropionates; D010423:Pentazocine