[Influence of autologous serum on leucocyte-migration-inhibition-test in melanomalignoma (author's transl)].
Influence of autologous serum on cellular immunological reactivity to melanomalignoma (MM)-associated antigens was examined on 20 patients have MM at different clinical stages, using the Leucocyte-Migration-Inhibition-Test (MIT). These 20 patients were referring to this till now not investigated. When heterologous serum (horse serum) was supplemented, an inhibition of cell-migration could be established in 15/20 cases, whereas a cell-migration inhibition in 14/20 cases was absent if autologous serum was added to culture medium. No correlation could be found between our test results and the clinical stage of the disease. Our results suggests urgently that blocking factors are present in serum of MM-patients. There is reason to believe that this factors will be active in lymphocyte level.
D000328:Adult; D000368:Aged; D000818:Animals; D000951:Antigens, Neoplasm; D002464:Cell Migration Inhibition; D005260:Female; D006736:Horses; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology; D008297:Male; D008545:Melanoma / Q000276:immunology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D007106:Immune Sera; D008263:Macrophage Migration-Inhibitory Factors
Der Einfluss von autologem Serum auf den Leukocyten-Migrations-Inhibitions-Test beim Melanomalignom