Clavulanic acid and penicillin treatment of Staphylococcus aureus renal infection in mice.
Clavulanic acid, an inhibitor of beta-lactamase, was used together with penicillin to treat infection caused by a penicillinase-producing Staphylococcus aureus. Clavulanic acid + penicillin administered to mice, prophylactically or in treatment of established infection, reduced morbidity, bacterial counts in the kidneys, and/or mortality; these differences were statistically significant when compared with those obtained by using penicillin or clavulanic acid alone.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D051379:Mice; D010400:Penicillin G / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D013997:Time Factors; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D010400:Penicillin G