title: Synthesis and pharmacological properties of 3-O-derivatives of 1,2,5,6-di-O-isopropylidene-alpha-D-glucofuranose.
abstract: A series of 3-O-derivatives of 1,2,5,6-di-O-isopropylidene-alpha-D-glucofuranose were prepared and tested for their pharmacological activity in comparison with tribenoside, a well known drug structurally related, and with other anti-inflammatory agents. Almost all the compounds had a very low toxicity and few of them showed a notable antiinflammatory and antipyretic activity and were able to clearly decrease the venous wall permeability.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D002199:Capillary Permeability / Q000187:drug effects; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006027:Glycosides / Q000138:chemical synthesis*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010276:Parasympatholytics / Q000138:chemical synthesis; D051381:Rats
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005960:Glucosides; D006027:Glycosides; D010276:Parasympatholytics