Increased development of PHA-stimulated murine colonies in vitro subsequent to adriamycin or daunorubicin treatment of spleen donor mice.
Spleen cell populations from mice treated with Adriamycin or daunorubicin were found to develop a greater PHA-stimulated clonal response than spleen cells from untreated or cyclophosphamide-treated animals. Daunorubicin, in addition, stimulated an unusual monocytic macrophage-like colony. The results are consistent with the possibility that the concentration of nonspecific T-lymphocyte progenitor and/or accessory cells in the spleen are increased consequent to drug treatment.
D000818:Animals; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008213:Lymphocyte Activation; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D008934:Mitogens; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology
D008934:Mitogens; D010835:Phytohemagglutinins; D004317:Doxorubicin; D003520:Cyclophosphamide; D003630:Daunorubicin