[Behavior of fluorescein dye in the vascularized cornea of the animal eye after local application of certain drugs (author's transl)].
In pigmented rabbits we investigated the much-used drugs pilocarpine, atropine, and tropicamide (Mydriaticum, Roche) with regard to their possible influence on the permeability of newly formed corneal vessels. Sodium fluorescein was chosen as test substance. Corneal vessels were produced by introcorneal injection of 0.1 N NaOH. Their development required 2--3 weeks and their growth about 4--6 weeks. A 2-week period of stability followed and was used for the local application of the above drugs. An evident influence on the diffusion of fluorescein could not be ascertained. Tropicamide induced a narrowing of the dye column in the corneal vessels. This phenomenon may be due to a narrowing of supplying vessels. In all cases, dye diffusion took place especially at the peripheral loops of the corneal vessels.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001808:Blood Vessels / Q000187:drug effects* / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D003315:Cornea / Q000098:blood supply*; D005456:Fluorescent Dyes / Q000378:metabolism*; D009184:Mydriatics / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D011817:Rabbits; D014331:Tropicamide / Q000494:pharmacology
D005456:Fluorescent Dyes; D009184:Mydriatics; D010862:Pilocarpine; D001285:Atropine; D014331:Tropicamide
Verhalten des Fluoresceinfarbstoffs an der vaskularisierten Cornea des Tierauges nach lokaler Medikamenteneinwirkung.