Double-blind trial of cholestyramine in post-vagotomy diarrhoea.
The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when compared with normal controls. These findings confirm the effectiveness of cholestyramine and support the concept of a bile acid mediated aetiology in post-vagotomy diarrhoea.
D001647:Bile Acids and Salts / Q000378:metabolism; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D005243:Feces / Q000032:analysis; D006801:Humans; D014628:Vagotomy / Q000009:adverse effects*
D001647:Bile Acids and Salts; D002792:Cholestyramine Resin