The pharmacology of 1841 CERM, a new analgesic.
A new non-narcotic analgesic, 2(3-trifluormethyl)-phenyl-tetrahydro-1,4-oxazine (1841 CERM) was compared with morphine, codeine and acetylsalicylic acid (ASA) in various pharmacological tests for analgesic activity. Studies for possible tolerance and physical dependence liability were also carried out. In these tests, 1841 CERM was a more powerful analgesic than morphine, and particularly codeine when given orally. It did not lead to tolerance or physical dependence.
D000700:Analgesics / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D051379:Mice; D009025:Morpholines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D019966:Substance-Related Disorders / Q000209:etiology
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009025:Morpholines