[Heat-stable Escherichia coli-enterotoxin: reduced action after administration of phenylbutazone in infant mice (author's transl)].
Heat-stable Escherichia coli enterotoxin was assayed by the method of DEAN determining gut weight to body weight ratios in infant mice. The enterotoxic responses were significantly lower than in saline treated controls when Phenylbutazone at 20 mcg/mouse was administered subcutaneously 30 minutes prior to intragastric toxin challenge. The trials were performed with lyophilized culture filtrates of E. coli O 149:K91 (B) K88 ab (L), and three other enterotoxigenic strains one of which was isolated from an outbreak of swine oedema disease, the other two strains originated from the stools of diseased children.
D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D004768:Enterotoxins / Q000633:toxicity*; D004926:Escherichia coli; D006358:Hot Temperature; D007279:Injections, Subcutaneous; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology*
D004768:Enterotoxins; D010653:Phenylbutazone
Hitzestabiles Escherichia coli-Enterotoxin: Wirkungsminderung durch Phenylbutazon.