Distribution of Lyb-4.1 and other membrane antigens on murine lymphoid tumors.
The distribution of membrane antigens on 6 DBA/2-derived tumors (L1210, L5178Y, P815, ABLS 11, ABLS 12, and ABLS 13) was studied by direct cytotoxicity and quantitative absorption assays. Lyb-4.1 antigen was found solely on the L1210 tumor. Iad antigens were absent from all tumors, and H-2Kd and H-2Dd antigens were present on all tumors. Immunoglobulin was adsorbed to the ascites tumors and lost after 3 days or more in tissue culture. These studies were performed to characterize the distribution of DBA/2 membrane antigens on DBA/2-derived tumors as a base line for functional and chemical studies with these tumors and with their solubilized proteins.
D000818:Animals; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D001402:B-Lymphocytes / Q000276:immunology*; D006183:H-2 Antigens; D007519:Isoantigens; D007939:Leukemia L1210 / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009363:Neoplasm Proteins / Q000276:immunology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006183:H-2 Antigens; D007519:Isoantigens; D008565:Membrane Proteins; D009363:Neoplasm Proteins