title: Effect of ovarian wedge resection for the Stein-Leventhal syndrome on plasma FSH, LH, oestradiol and testosterone levels and on the responses of the pituitary to intravenous LHRH.
abstract: We studied basal plasma FSH, LH, testosterone and oestradiol levels and post-OHRH plasma FSH and LH levels in ten patients both before and after a wedge resection of the ovaries for Stein-Leventhal syndrone. We compared the results with those obtained in 15 healthy patients between the third and seventh day of a normal menstrual cycle. Before operation, patients with the Stein-Leventhal syndrome had raised basal and post-LHRH LH levels and raised plasma testosterone levels. All these abnormalities disappeared after wedge resection of the ovaries. Both before and after operation patients with the Stein-Leventhal syndrome had low plasma oestradiol levels. These results are used to formulate a hypothesis about the aetiology of the Stein-Leventhal syndrome.
mesh_terms: D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006728:Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000601:surgery*; D010902:Pituitary Gland / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000601:surgery*; D013739:Testosterone / Q000097:blood
chemical_list: D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone