The effects of methylprednisolone on the complications of coronary artery surgery.
Complications of coronary artery surgery were analyzed in a prospective controlled study of 150 patients, one group receiving methylprednisolone before temporary cardiopulmonary bypass. The patient population was comparable in both the groups. The number of deaths were the same in both the groups, myocardial infarction and cardiac arrhythmias were definitely lower in the Solu-Medrol group. Cerebral vascular accidents were higher in the control group and there were none in the drug treated group. Incidences of pulmonary embolism was reduced by the drug. Oxygen consumption by the tissues was higher in the Solu-Medrol treated group. There were no known complications of the drug, such as stress ulcer and infection. One patient did receive prophylactic antibiotics. Solu-Medrol was deliberately given in patients who were known to have uncomplicated duodenal ulcer. Post-operative bleeding in patients with duodenal ulcer was not noted. This could be explained due to the short acting nature of Solu-Medrol. We feel that Solu-Medrol does minimize serious sequelae of heart-lung machine in coronary artery surgery.
D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D001158:Arteries / Q000601:surgery; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003331:Coronary Vessels / Q000378:metabolism / Q000601:surgery; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control; D010101:Oxygen Consumption; D011183:Postoperative Complications; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology
D006493:Heparin; D008775:Methylprednisolone