Effects of tilorone hydrochloride on cellular immunity (leukocyte inhibiting factor production from human lymphocyte stimulated by E. coli lipopolysaccharide).
Tilorone hydrochloride, a drug able selectively to affect T-lymphocyte fuction, when incorporated (at three different concentrations 0.1, 0.04, 0.02 microgram/ml) in lymphocyte culture, stimulated by 50 microgram/ml of E. coli LPS (026:B6 W), is able to abolish LIF production, due to endotoxin stimulation. Such effect is, may be, due to an impairment of T-cell activity, since tilorone at the same concentration decreases the number of ARFC and TRFC, which are specific markers for T-cells.
D004926:Escherichia coli / Q000276:immunology; D005449:Fluorenes / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D013994:Tilorone / Q000494:pharmacology*
D005449:Fluorenes; D008070:Lipopolysaccharides; D008263:Macrophage Migration-Inhibitory Factors; D011135:Polysaccharides, Bacterial; D013994:Tilorone