title: Pharmacokinetic monitoring of high-dose methotrexate. Early recognition of high-risk patients.
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy; D012306:Risk; D013997:Time Factors
chemical_list: D002955:Leucovorin; D008727:Methotrexate