title: Reduction of dental decay in rampant caries individuals following short-term kanamycin treatment.
abstract: A week of kanamycin gel treatment before and after the placement of dental restorations, compared to a placebo gel treatment, significantly reduced the levels of cultivable bacteria, S mutans and S sanguis, in the plaque samples collected immediately after the completion of the gel treatments, and was associated with a 46% reduction in new carious surfaces in the 14- to 37-month period following the gel treatment.
mesh_terms: D000293:Adolescent; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003731:Dental Caries / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D003793:Dental Restoration, Permanent; D005782:Gels; D006801:Humans; D007612:Kanamycin / Q000627:therapeutic use*; D010919:Placebos; D012463:Saliva / Q000382:microbiology; D013295:Streptococcus mutans / Q000166:cytology; D013298:Streptococcus sanguis / Q000166:cytology
chemical_list: D005782:Gels; D010919:Placebos; D007612:Kanamycin