Evidence for antibody-dependent cell-mediated cytotoxicity by T cells bearing receptors for IgG.
Human lymphocyte populations comprising T cells, T depleted lymphocytes, and T cells enriched for, or depleted of, IgG Fc receptor-bearing (TG) cells, were separated using rosette techniques. All lymphocytes were assessed for the ability to lyse antibody-coated chicken erythrocytes and SL2 mouse lymphoma cells. Their activity was compared with that of monocytes and neutrophil-enriched preparations. IgG Fc receptor positive cells within the T population were highly active in both cytotoxicity assays; the activity could not be ascribed to contamination by monocytes or neutrophils. The TG cells forming junctions with the target cells possessed a characteristic ultrastructure.
D000920:Antibody-Dependent Cell Cytotoxicity; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D066298:In Vitro Techniques; D007365:Intercellular Junctions / Q000648:ultrastructure; D008854:Microscopy, Electron; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G