Controlled trial of the effect of cycloalliin on the fibrinolytic activity of venous blood.
Cycloalliin is a natural constituent of onion, sulphur-containing but odourless. It was synthesised for this randomised double-blind study; its effect on fibribolytic activity and platelet aggregability was tested in venous blood from 18 male volunteers. It increased the former to a highly significant degree but had no effect on the latter. It was well tolerated and harmless in the single oral dosage used.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006577:Heterocyclic Oxides / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010875:Pipecolic Acids / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects
D005343:Fibrinolytic Agents; D006577:Heterocyclic Oxides; D010875:Pipecolic Acids; C015094:cycloalliin