[Immunodiagnosis of malignant disease. I. The electrophoresis-mobility test in the diagnosis of bronchial carcinoma (author's transl)].
The electrophoresis-mobility test is an in-vitro method for demonstrating specific sensitized lymphocytes. After incubation with the encephalitogenic factor, lymphocytes from patients with malignant disease liberate a factor which causes a decrease in migration velocity of indicator cells (tanned and sulphosalicyl acid-stabilised sheep erythrocytes = ETS) in an electrical field. 84 patients with pulmonary disease and 20 control persons were examined. An inhibition of ETS migration was found only in patients with malignant pulmonary disease, while in the control subjects and those with inflammatory or degenerative pulmonary disease or benign pulmonary tumour ETS migration was accelerated. The difference between the two groups is statistically significant so that it provides a reliable differentiation between benign and malignant disease. False-negative results, however, occur under radiotherapy and chemotherapy.
D001984:Bronchial Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D002464:Cell Migration Inhibition; D003937:Diagnosis, Differential; D004586:Electrophoresis; D006801:Humans; D007158:Immunologic Techniques; D008171:Lung Diseases / Q000175:diagnosis; D008214:Lymphocytes
Immundiagnostik maligner Erkrankungen. I. Der Elektrophorese-Mobilitäts-Test in der Diagnostik des Bronchialkarzinoms