title: Kidney transplantation following treatment with cyclophosphamide and bone marrow grafting.
abstract: Canine cyclophosphamide (CY) chimeras permanently accept kidney and skin grafts as do radiation chimeras. Three of five dogs with reversion of chimerism rejected their kidney grafts within 11-16 days, while two of them retained their kidney grafts permanently. These results suggest that the reversion of chimerism in CY chimeras may be due to different mechanisms, either immunologic rejection or a nonimmunologic substitution of the grafted marrow by the host's own hemopoiesis.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000494:pharmacology*; D004285:Dogs; D006084:Graft Rejection; D007621:Karyotyping; D016030:Kidney Transplantation; D011828:Radiation Chimera; D014184:Transplantation, Homologous
chemical_list: D003520:Cyclophosphamide