title: Antihypertensive therapy in elderly patients. Pilot trial of the European Working Party on High Blood Pressure in the Elderly.
abstract: A study protocol for a double-blind randomised control trial of hypotensive treatment in elderly hypertensive patients has been tested in a number of pilot centres throughout Europe. It was shown that this study is possible from the logistic point of view. In these elderly patients, hydrochlorothiazide + triamterene treatment with or without methyldopa, maintained a significant hypotensive effect in the absence of major electrolyte disturbances. The initiation of hypotensive therapy did not provoke an excess of cardiovascular complications. The influence of hypotensive therapy on the general well-being and on the morbidity and the mortality of elderly patients with high blood pressure, is thereby being assessed. The study will continue for 5 years and other centres are invited to join.
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001835:Body Weight; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D008875:Middle Aged; D010919:Placebos; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014223:Triamterene / Q000627:therapeutic use; D014527:Uric Acid / Q000097:blood
chemical_list: D010919:Placebos; D006852:Hydrochlorothiazide; D014527:Uric Acid; D008750:Methyldopa; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D014223:Triamterene