Measurement of dermal atrophy induced by topical steroids using a radiographic technique.
A modified radiographic technique was used to assess dermal atrophy induced by topical steriods. The method proved reliable, and significant atrophy occurred with fluocinolone acetonide, clobetasone butyrate, hydrocortisone 17-butyrate and flurandrenolone, but not with hydrocortisone.
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001284:Atrophy; D002986:Clinical Trials as Topic; D002990:Clobetasol / Q000031:analogs & derivatives / Q000494:pharmacology; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D005478:Flurandrenolone / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008722:Methods; D011859:Radiography; D012867:Skin / Q000000981:diagnostic imaging / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D005446:Fluocinolone Acetonide; D005478:Flurandrenolone; D002990:Clobetasol; D006854:Hydrocortisone