Stability of 70S ribosomes in relation to misreading and antibacterial activity of aminoglycosides.
The anomeric aminoglycosides, RU 21886 and RU 23468, which both have a 2-deoxystreptamine residue, stabilize 70S ribosomes to similar extents at low magnesium ion concentrations. Only RU 21886, however, has marked antibacterial and bactericidal activity and gives rise to a high level of misreading in cell-free protein synthesizing systems. It would thus appear that the ability to stabilize the association of the two ribosomal subunits does not necessarily lead to errors in translation.
D000617:Aminoglycosides / Q000494:pharmacology; D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D007700:Kinetics; D009113:Muramidase / Q000096:biosynthesis; D009355:Neomycin / Q000494:pharmacology; D010303:Paromomycin / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
D000617:Aminoglycosides; D010303:Paromomycin; D009113:Muramidase; D009355:Neomycin