[Increasing the non-specific resistance of animals to pathogenic E. coli with preparations of RNA].
Yeast RNA and sodium nucleinate considerably increased the nonsusceptibility of mice to pathogenic escherichia and typhoid salmonellae. Ineffective single nucleonate doses created an intense resistance in repeated use; prolonged application was not accompanied by the appearance of tolerance to the preparation. The principal mechanism of the induced phenomenon consisted in the intensification of the bacterial elimination and the endotoxin detoxification chiefly realized by the activity of the mobile phagocytes.
D000818:Animals; D004731:Endotoxins / Q000378:metabolism; D004927:Escherichia coli Infections / Q000517:prevention & control*; D051379:Mice; D012313:RNA / Q000008:administration & dosage / Q000627:therapeutic use*; D014435:Typhoid Fever / Q000517:prevention & control*; D015003:Yeasts / Q000032:analysis
D004731:Endotoxins; D012313:RNA
Povyshenie preparatami RNK nespetsificheskoĭ rezistentnosti zhivotnykh k patogennym E. coli