Patterns of clinical disease associated with antibodies to nuclear ribonucleoprotein.
Forty-three patients were studied whose sera were monospecific for nuclear ribonucleoprotein by double immunodiffusion. Thirty-four patients had features typical of systemic lupus erythematosus of which 30 fulfilled the American Rheumatism Association criteria. Clinical features such as rashes, serositis and hematological abnormalities occurred with a frequency expected in SLE. Raynaud's phenomenon occurred in 60%, but other features of mixed connective tissue disease were uncommon. Clinical evidence of renal disease occurred in only four patients. In our experience a good prognosis is related more to the presence of anti-nRNP alone in the serum than to any specific set of clinical findings.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008947:Mixed Connective Tissue Disease / Q000276:immunology; D009698:Nucleoproteins / Q000276:immunology*; D011928:Raynaud Disease / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000276:immunology
D000974:Antibodies, Antinuclear; D009698:Nucleoproteins; D012261:Ribonucleoproteins