[Immunsuppression under vitamin B6 deficiency (author's transl)].
The influence of a Vitamin B6 free diet and the effect of Desoxipyridoxin (a potent Vitamin B6 Antagonist) on the immunesystem of mice was investigated in several experimental setups. Rejection times of skintransplants from inbred strains (129 J) on C57bl/6J mice served as a model for immunosuppression. Rejection times under alimentary Vitamin B6 deficiency did not exceed those under hypocaloric nutrition associated with comparable weight loss. Immunosuppression with the Vitamin B6 antagonist Desoxipyridoxin was much more pronounced. The effect was related to the duration of treatment. Desoxipyridoxin offers the possibility of effective immunsuppression, which is readily reversible.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D007165:Immunosuppression Therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D011736:Pyridoxine / Q000031:analogs & derivatives; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D026681:Vitamin B 6 Deficiency / Q000276:immunology*
D000963:Antimetabolites; D011736:Pyridoxine
Immunsuppression durch Vitamin-B6-Mangel. Eine experimentelle Studie mit Hauttransplantaten an Inzuchtmäusen