Sparing of bone marrow stem cells by long-term administration of Na-alginate to 226Ra contaminated mice.
226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against alpha-irradiation from 226Ra contamination. Doses from 4 to 14 micronCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed. but from 9.0 micronCi/kg a decrease in the number of surviving stem cells is observable in non treated animals. while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226 Ra dose which accounts for damage to marrow stem cells within the range of alpha-rays at the endosteal surfaces.
D000464:Alginates / Q000494:pharmacology*; D000512:Alpha Particles; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003114:Colony-Forming Units Assay; D004032:Diet; D005269:Femur / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D006811:Humerus / Q000378:metabolism; D007501:Iron / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011883:Radium / Q000378:metabolism*
D000464:Alginates; D007501:Iron; D002118:Calcium; D011883:Radium