Passive enhancement of rat renal allografts by antibodies to a non-SD (Ag-B) locus analogous to Ia and demonstration of linkage to the MHC.
The rat MHC contains a distinct locus for Ia-like antigens. The alleles of this locus are not always associated with like alleles of the MLR and Ag-B (SD) loci in inbred strains. This is demonstrated by the Fischer strain, which is MLR and tag-B (SD) 1 (H-11) but shares an Ia specificity with BN (Ag-B3, H-1n). The biologic significance of anti-Ia is distinctive, having in vivo graft-enhancing capability, even when it is cross-reacting (i.e., Lew anti-Fi enhances BN). In contrast, anti-AG-B (SD) does not enhance in the rat model.
D000818:Animals; D000906:Antibodies; D002874:Chromosome Mapping; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D008040:Genetic Linkage; D006386:Hemagglutination Tests; D006649:Histocompatibility Antigens; D007116:Immunization, Passive; D007158:Immunologic Techniques; D016030:Kidney Transplantation; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous
D000906:Antibodies; D006649:Histocompatibility Antigens