Collagen stimulates more platelet prostaglandin endoperoxides in thrombosis.
Platelets prostaglandin cyclic endoperoxides after collagen stimulation were measured in 7 patients with arterial thrombosis, 4 patients with recurrent deep venous thrombosis and 27 patients before undergoing total hip replacement. Patients with post-surgical D.V.T. synthetized more platelet cyclic-endoperoxides compared to those with no D.V.T. COULD BE DIVIDED INTO 2 SUBGROUPS : GROUP I with platelet cyclic endoperoxides and group II with higher cyclic-endoperoxides synthesis. Also, there was a higher ratio of platelet cyclic endoperoxides in patients with arterial thrombosis and in 2 patients with recurrent venous thrombosis and shortened platelet survival time. Thus, a greater synthesis of platelet prostaglandin cyclic, endoperoxides was formed in a number of patients with thrombosis.
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002986:Clinical Trials as Topic; D003094:Collagen / Q000494:pharmacology*; D006615:Hip / Q000601:surgery; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D011183:Postoperative Complications / Q000097:blood; D011453:Prostaglandins / Q000096:biosynthesis*; D013924:Thrombophlebitis / Q000097:blood; D013927:Thrombosis / Q000097:blood*
D011453:Prostaglandins; D003094:Collagen