Monoclonal antibodies defining distinctive human T cell surface antigens.
Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.
D000818:Animals; D000918:Antibody Specificity; D000954:Antigens, Surface / Q000032:analysis*; D002478:Cells, Cultured / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D006801:Humans; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D010954:Plasmacytoma / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface