Studies on the adjuvant effect of water-in-oil-in-water (w/o/w) emulsion of sesame oil. 2. Mode of action of the w/o/w emulsion.
The water-in-oil-in-water (w/o/w) emulsion showed potent adjuvant effect on the antibody formation to thymus-dependent antigens, but not to thymus-independent antigens. In hapten-carrier system the priming with carrier in the w/o/w emulsion enhanced more effectively the carrier specific helper function than did the priming with carrier in free solution. The cells responsible for the helper function were radioresistant. In the adoptive cell transfer system, the w/o/w emulsion was shown to enhance helper cell function. It is discussed that our w/o/w emulsion exerts the adjuvant effect by enhancing helper T cell activity.
D000276:Adjuvants, Immunologic / Q000592:standards; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000032:analysis; D004655:Emulsions; D005260:Female; D006241:Haptens / Q000276:immunology; D008297:Male; D051379:Mice; D012715:Sesame Oil; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014867:Water
D000276:Adjuvants, Immunologic; D000941:Antigens; D004655:Emulsions; D006241:Haptens; D014867:Water; D012715:Sesame Oil