[Clindamycin-2-phosphate and surgical infections (author's transl)].
Blood levels of clindamycin-2-phosphate in dog at dosis of 10 mg/kg body weight showed the maximum of 21 mug/ml 30 seconds after one-shot i.v. administration. Continuous infusion of the antibiotic at the infusion speed of 150 and 300 ml/hour/10 kg b.w. with 6 mg/ml solution maintained blood levels of 30 and 170 mug/ml respectively. It may be recommended clinically to use lower concentration than 6 mg/ml to avoid cardiocirculatory disturbances. Four cases of surgical mixed infections with gram-positive cocci, gram-negative bacilli and anaerobes were treated with clindamycin-2-phosphate at a daily dosis of 1,200 mg intravenously and 2 of 4 cases revealed good clinical response. There was none of the haematological, hepatic, nephrontic, cardiocirculatory and allergic side effects.
D000038:Abscess / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000818:Animals; D002981:Clindamycin / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004285:Dogs; D004938:Esophageal Neoplasms / Q000150:complications; D006801:Humans; D008100:Liver Abscess / Q000188:drug therapy; D008297:Male; D008477:Mediastinal Diseases / Q000188:drug therapy; D008875:Middle Aged; D009943:Organophosphorus Compounds; D011014:Pneumonia / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy; D012002:Rectal Diseases / Q000188:drug therapy; D014138:Tracheoesophageal Fistula / Q000150:complications
D009943:Organophosphorus Compounds; D002981:Clindamycin