title: Response profiles: A method of evaluating the activity of beta-lactam antibiotics against Enterobacteria.
abstract: A method is described which may be used to compare the relative activity of beta-lactam antibiotics against gram-negative bacilli. The method offers several important advantages over conventional methods of evaluation of the antibacterial activity of beta-lactam agents: the bacterial inoculum is simply and accurately standardized; the response of the culture is continuously monitored and information is obtained on both the intrinsic activity of the agent and its susceptibility to enterobacterial beta-lactamases. In this way, differences in the antibacterial activity of compounds which appear similar on the basis of more conventional tests may be revealed.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002228:Carbenicillin / Q000494:pharmacology; D002437:Cefazolin / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D002509:Cephaloridine / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology; D002515:Cephradine / Q000494:pharmacology; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009391:Nephelometry and Turbidimetry; D010400:Penicillin G / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D000667:Ampicillin; D002515:Cephradine; D002228:Carbenicillin; D002437:Cefazolin; D002509:Cephaloridine; D002506:Cephalexin; D010400:Penicillin G; D002512:Cephalothin