[Treatment with Chloranphenicol of neonatal sepsis-meningitis by gram-negative bacteria (author's transl)].
Eight newborn infants having previously received broad spectrum antibiotics were treated with intravenous chloranphenicol succinate for sepsis-meningitis during a klebsiella neumoniae outbreak. Five of them survived without sequelae. Over the third week of treatment two infants developed a transient bone marrow suppresion accompanied by a "pseudo-septic" clinical picture; this syndrome, that we have not found previously reported, was benign, disappearing when the drug was discontinued.
D002701:Chloramphenicol / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007710:Klebsiella Infections / Q000188:drug therapy*; D007711:Klebsiella pneumoniae; D008297:Male; D008581:Meningitis / Q000188:drug therapy*
D002701:Chloramphenicol
Tratamiento con cloranfenicol de la sepsis-meningitis neonatal por gram-negativos.