Low molecular weight intracellular iron transport compounds.
Evidence is presented for the existence of an intracellular pool of low molecular weight iron compounds which acts as an intermediate between extracellular iron and a wide variety of intracellular processes. It is in equilibrium with storage iron and iron enzymes and is of major importance in iron toxicity and chelation therapy.
D001692:Biological Transport; D002460:Cell Line; D003600:Cytosol / Q000032:analysis; D003676:Deferoxamine / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005293:Ferritins / Q000096:biosynthesis; D006418:Heme / Q000096:biosynthesis; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology; D007501:Iron / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D007502:Iron Chelating Agents / Q000378:metabolism; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism; D010586:Phagocytes / Q000378:metabolism
D007502:Iron Chelating Agents; D006418:Heme; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine