[Peptone-stimulated gastric secretion and antacids. Effect of antacids with various content of calcium, magnesium and aluminiumions on the peptone-induced secretion of gastric juice, double-blind study].
A double-blind-trial was performed to prove the effect of antacids containing Mg (OH)2, Al (OH)3 and CaCO3 on peptone-stimulated gastric secretion (intragastric titration). A high efficacy of antacids given after meals was demonstrated. After application of antacids no significant rise in serum gastrin levels during intragastric titration was found. Serum calcium and magnesium levels remained unchanged. Peptone-stimulated gastric secretion was not influenced by application of different antacids within a period of 2 hours.
D000535:Aluminum / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D010461:Peptones / Q000008:administration & dosage*; D013268:Stimulation, Chemical; D013270:Stomach / Q000502:physiology
D000863:Antacids; D010461:Peptones; D000535:Aluminum; D008274:Magnesium; D002118:Calcium
Peptone-stimulierte Magensäure-Sekretion und Antazida. Die Wirkung von Antazida mit unterschiedlichem Gehalt an Kalzium-, Magnesium- und Aluminium-Ionen auf die Peptone-induzierte Magensäure-Sekretion, Doppelblind-Studie.