title: Changes in ingestive behavior following interruption of a noradrenergic projection to the paraventricular nucleus: histochemical and neurochemical analyses.
abstract: Histochemical investigation of the paraventricular nucleus (PVN) identified the tractus filiformis lateralis (TF) as a major noradrenergic preterminal pathway to the PVN. Bilateral knife cuts transecting the TF resulted in a discrete deafferentation of 56% of the noradrenergic input to the PVN region. TF transection also resulted in hypophagia and hypodipsia during the first four days after surgery. A marked hyperdipsia developed between postoperative Days 11 and 13 and persisted until sacrifice on Day 17. The results suggest that the TF contains a noradrenergic system which innervates the PVN and is involved in mediation of ingestive behaviors.
mesh_terms: D000320:Adrenergic Fibers / Q000033:anatomy & histology / Q000502:physiology*; D000344:Afferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000502:physiology; D003714:Denervation; D004298:Dopamine / Q000378:metabolism; D004327:Drinking Behavior / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D008474:Medial Forebrain Bundle / Q000033:anatomy & histology; D009638:Norepinephrine / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats
chemical_list: D004298:Dopamine; D009638:Norepinephrine