Lymphocyte responsiveness to urinary glycosaminoglycan in systemic scleroderma.
From the urine of patients with systemic scleroderma, we previously isolated a glycosaminoglycan, which could induce a scleroderma-like change in the skin of mouse. In the present work, the cell-mediated response to urinary glycosaminoglycans was examined by lymphocyte transformation test. The specific response was observed in lymphocytes of patients with scleroderma, when the above scleroderma-inducing glycosaminoglycan was added. By contrast, lymphocytes of patients with SLE or dermatomyositis and of normal persons hardly showed a response to this glycosaminoglycan. On the other hand, the glycosaminoglycans from normal urine could not stimulate lymphocytes of patients with scleroderma or healthy persons.
D000941:Antigens; D003882:Dermatomyositis / Q000276:immunology; D006025:Glycosaminoglycans / Q000276:immunology / Q000652:urine*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008213:Lymphocyte Activation; D012595:Scleroderma, Systemic / Q000276:immunology / Q000652:urine*; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D006025:Glycosaminoglycans