[Action of 5-hydroxytryptophan on serum thyreostimulin and prolactin in primary hypothyroidism (author's transl)].
Orally 5 HTP has significantly decreased serum TSH level in eight patients with primary non treated hypothyroidism, but not in five normal subjects. Serum T4 et T3 levels did not change and serum PRL did not increase in the two groups. These results indicate a possible inhibitory action of 5 HT on TSH regulation. Action of 5 HT on PRL has not been defined here.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D012701:Serotonin / Q000494:pharmacology; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D012701:Serotonin; D011388:Prolactin; D013972:Thyrotropin; D006916:5-Hydroxytryptophan; D013974:Thyroxine
Action du 5 hydroxytryptophane sur les taux plasmatiques de thyréostimuline et de prolactine dans l'hypothyroïdie primitive et chez le sujet normal.