Effect of ethacrynic acid upon the peripheral vestibular nystagmus.
The effect of ethacrynic acid (ETA) upon pendular rotation nystagmus and paralytic nystagmus was examined using 61 guinea pigs. 100 mg/kg ETA reduced these nystagmus but 30 mg/kg ETA had on effect. Galvanic nystagmus, Bechterew's compensatory nystagmus, OKN and EEG were not affected by 100 ng/kg ETA. These results are highly suggestive that the inhibition of the peripheral vestibular nystagmus by ETA is mainly due to the reduction of the ampullar endolymphatic potential.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation; D004710:Endolymph / Q000502:physiology; D004976:Ethacrynic Acid / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects*; D006168:Guinea Pigs; D012399:Rotation; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D004976:Ethacrynic Acid