The effect of homologous local anesthetics of the 4-alkoxy- and 4-alkylamino-benzoic acid-diethylamino-esthylester- hydrochloride series on the glucose transport in human erythrocytes.
The homologous compounds of the 4-alkoxy- and 4-alkylamino-series inhibit the exchange transport of glucose in human erythrocytes; they show a competitive inhibition with one or two inhibitor molecules which become bound to a singular site of the transport system for glucose. The importance of length of hydrocarbon chain of the localanesthetics for the mode of their action is discussed.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D062365:Aminobenzoates / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004912:Erythrocytes / Q000378:metabolism*; D005021:Ethylamines / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D062385:Hydroxybenzoates / Q000494:pharmacology*; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D000779:Anesthetics, Local; D001786:Blood Glucose; D005021:Ethylamines; D062385:Hydroxybenzoates; D062366:para-Aminobenzoates; D005947:Glucose; D010129:4-Aminobenzoic Acid