Metabolism of para-aminobenzoate over time.
Potassium para-aminobenzoate incorporated into rat chow was fed ad libitum for 14 days to adult female Buffalo rats. Determination of the principal urinary metabolites, namely, p-aminobenzolyacetylester and p-aminobenzoylglucuronide, namely, p-aminobenzoylacetylester and p-aminobenzoylglucuronide, as well as p-aminobenzoylglycine and p-hydroxybenzoylglycine (hippurates), showed significantly greater amounts of the metabolites at the 14th day compared to day 1. There was no significant change in free p-aminobenzoate excretion during this interval. The results suggest that para-aminobenzoate stimulates its own metabolism during chronic administration.
D010129:4-Aminobenzoic Acid / Q000378:metabolism*; D000107:Acetylation; D062365:Aminobenzoates / Q000378:metabolism*; D000818:Animals; D005260:Female; D005965:Glucuronates; D051381:Rats; D010130:p-Aminohippuric Acid / Q000652:urine
D062365:Aminobenzoates; D005965:Glucuronates; D010129:4-Aminobenzoic Acid; D010130:p-Aminohippuric Acid