title: The effect of lithium carbonate on affect, mood, and personality of normal subjects.
abstract: Data reflecting affect, mood, and personality attributes of 23 normal men were compared after two weeks of placebo administration and two weeks of therapeutic serum lithium levels (mean, 0.91 mEq/liter). The study was a placebo-controlled, split-half crossover, double-blind design. Affect and mood were measured by three self-rating instruments, independent rater observation, and by the subjects' "significant others." Two personality inventories were administered. Substantial affect and mood changes are induced by lithium carbonate. Lethargy, dysphoria, a loss of interest in interacting with others and the environment, and a state of increased mental confusion were reported. No generalized effects were found in the responses to ther personality inventories.
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D001007:Anxiety / Q000139:chemically induced; D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000139:chemically induced; D003221:Confusion / Q000139:chemically induced; D004644:Emotions / Q000187:drug effects*; D005221:Fatigue / Q000139:chemically induced; D006801:Humans; D007398:Interpersonal Relations; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009325:Nausea / Q000139:chemically induced; D010551:Personality / Q000187:drug effects*; D010555:Personality Inventory; D010919:Placebos; D012647:Self-Assessment; D013974:Thyroxine / Q000097:blood
chemical_list: D010919:Placebos; D008094:Lithium; D013974:Thyroxine