[Effect of furosemide on the pharmacokinetics of benzylpenicillin and its penetration through the hematoencephalic barrier in experimental and clinical meningococcic meningitis].
Pharmacokinetics of sodium benzylpenicillin after intramuscular administration in a dose of 250 000 gamma/kg and simultaneous intramuscular injection of furosemid (lazix) in doses of 0.5--1--2 mg/kg was studied in experiments on a model of meningococcal meningitis of rabbits and in clinics on patients with meningococcal meningitis. A pronounced effect of furosemid on pharmacokinetics of benzylpenicillin as dependent on a number of factors was found. Furosemid and meningococcal endotoxin had a synergic effect and decreased benzylpenicillin excretion with urine resulting in prolongation of the antibiotic effect in the blood. An increase in benzylpenicillin blood levels and inflammation of the soft brain membranes increased permeability of the hemato-encephalic barrier for the antibiotic.
D000818:Animals; D001702:Biopharmaceutics; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D007700:Kinetics; D008585:Meningitis, Meningococcal / Q000188:drug therapy*; D010400:Penicillin G / Q000032:analysis / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D005665:Furosemide; D010400:Penicillin G
Vliianie furosemida na farmakokinetiku benzilpenitsillina i proniknovenie ego cherez gematoéntsefalicheskiĭ bar'er pri meningokokkovom meningite v éksperimente i klinike.