Effect of diazepam on cerebral 5-hydroxytryptamine synthesis.
In the brains of normal and reserpinized rats both diazepam and amino-oxyacetic acid (AOAA) decreased the 5-hydroxytryptophan (5HTP) accumulation induced by the decarboxylase inhibitor 3-hydroxybenzylhydrazine (NSD 1015). In reserpinized animals, the action of diazepam was antagonized by picrotoxin and bicuculline in doses which did not themselves influence the NSD 1015-induced rise in 5HTP. In conclusion, diazepam probably depresses 5HT synthesis via GABAergic mechanisms and this effect is not dependent on a functionally intact monoaminergic synaptic transmission.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000096:biosynthesis*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D006916:5-Hydroxytryptophan; D000625:Aminooxyacetic Acid; D001640:Bicuculline; D003975:Diazepam; D010852:Picrotoxin; D012110:Reserpine; D012701:Serotonin; D005680:gamma-Aminobutyric Acid