title: [Genetic structure of Staphylococcus epidermidis strain No. 17 possessing penicillinase and bacteriocinogenic activity].
abstract: The studies on the genetic structure of Staphylococcus epidermidis, strain 17 showed that this strain possessed a factor of bactericinogenicity of the one type, which was an extrachromosomal element not bound with penicillinase activity. The loss of the bacteriocinogenicity factor spontaneously or under the effect of acridine orange at a temperature of 37 degrees C was not observed. Passages of the strain at a temperature of 44 degrees C for 5 days and acridine orange proved to be the most effective eliminating factors. The loss of the bacteriocinogenicity plasmid did not result in changing any biochemical properties of the strain but was accompanied by a loss of the immunity to bacteriocin of the initial strain. The study of the growth regularities of the initial strain and its variant deprived of the bacteriocinogenicity plasmid showed that multiplication of the cells in the presence of the plasmid practically started without the latent period.
mesh_terms: D000165:Acridine Orange / Q000494:pharmacology; D001430:Bacteriocins / Q000096:biosynthesis*; D005111:Extrachromosomal Inheritance / Q000187:drug effects; D010405:Penicillinase / Q000235:genetics*; D010957:Plasmids / Q000187:drug effects; D013210:Staphylococcus / Q000201:enzymology / Q000235:genetics*; D013696:Temperature; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001430:Bacteriocins; D010405:Penicillinase; D001618:beta-Lactamases; D000165:Acridine Orange
vernacular_title: Issledovanie geneticheskoĭ struktury shtamma Staphylococcus epidermidis No. 17, obladaiushchego penitsillinaznoĭ i bakteriotsinogennoĭ aktivnost'iu.