Immune response to immunization via the anterior chamber of the eye. I. F. lymphocyte-induced immune deviation.
The immunizing abilities of alloantigens placed within the anterior chamber of the eye have been studied in inbred rats. Although intracameral inoculation of F1 hybrid lymphocytes into parental strain recipients elicited both cell- and antibody-mediated immunity, a delimited interval was identified postinoculation during which the systemic cell-mediated immune response was suppressed as indicated by prolonged acceptance of orthotopic skin allografts. The prompt appearance of hemagglutinating antibodies in the serum of immunized rats followed a time course which coincided with the suppression of cell-mediated immunity and suggested that the two events are casually related. Since exposure to allogeneic antigens on lymphoid cells via the anterior chamber elicits a transient suppression in cell-mediated immunity, where humoral immunity is preserved, the phenomenon resembles immune deviation.
D000818:Animals; D000867:Anterior Chamber / Q000276:immunology*; D000917:Antibody Formation; D003601:Cytotoxicity Tests, Immunologic; D006084:Graft Rejection; D006386:Hemagglutination Tests; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007519:Isoantigens; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D051381:Rats; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D007519:Isoantigens