[Malignant histiocytosis (author's transl)].
According to observations in six patients and published reports, malignant histiocytosis is characterized by premature multifocal proliferation of atypical histiocytes, especially in lymph-nodes, spleen, liver, bone marrow, and lung. The diagnosis can be confirmed by electron-microscopy, and enzyme as well as immunocytochemical tests. Fever, anaemia, leukopenia (with absolute reduction in T-lymphocytes), and jaundice are frequent. Immunoglobulins are normal or polyclonally increased. Malignant histiocytosis is more like monocyte leukaemia and histiocytosis X than neoplasms of the lymphatic system.
D000328:Adult; D001344:Autopsy; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013156:Splenectomy
D007136:Immunoglobulins
Maligne Histiozytose.