Mitogenic activity of an extract of Trypanosoma gambiense.
An extract obtained by repeated freeze/thawing of a freshly isolated strain of Trypanosoma gambiense caused stimulation of lymphocytes obtained from healthy adult donors and from cord blood. The active factor had some stimulatory effect on purified B and T lymphocytes and in two of five subjects increased IgM production by lymphocytes cultured in vitro. A trypanosome-derived mitogenic factor may play some part in the pathogenesis of the hypergammaglobulinaemia characteristic of African trypanosomiasis.
D000818:Animals; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007376:Interleukin-2 / Q000134:cerebrospinal fluid / Q000302:isolation & purification; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D014347:Trypanosoma brucei gambiense / Q000276:immunology*
D007075:Immunoglobulin M; D007376:Interleukin-2