title: Advances in the morphological diagnosis of bone tumours: cytology, cytochemistry, acrylate embedding and electron microscopy (author's transl).
abstract: An exact morphological diagnosis of bone tumours is the prerequisite for selective treatment. In a given case this may present great difficulties, partly because of the rarity of a tumour group and thus lack of experience, partly faulty removal of the specimen and unsatisfactory further technical handling. Progress can be expected only by widening the spectrum of methods by using modern morphological tests. In a programme using imprint cytology, cytochemistry, rapid section, histochemistry, paraffin, non-decalcified embedding in acrylate and electron microscopy it was demonstrated in 78 cases of bone tumour (seen over a period of two years) that with these tests, especially cytology, cytochemistry and non-decalcified acrylate histology, significant improvement can be obtained in the morphological diagnosis of bone tumours. In addition, new lights on cytogenesis and pathogenesis of these tumours and possible points of attack of cytostatic treatment are provided.
mesh_terms: D000293:Adolescent; D000328:Adult; D001847:Bone Diseases / Q000473:pathology; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D005260:Female; D006101:Granuloma, Giant Cell / Q000473:pathology; D006651:Histocytochemistry; D006652:Histological Techniques; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009221:Myositis Ossificans / Q000473:pathology; D012516:Osteosarcoma / Q000473:pathology
vernacular_title: Methodische Fortschritte in der morphologischen Diagnostik der Knochentumoren. Zytologie, Zytochemie, Kunststoffeinbettung und Elektronenmikroskopie.