Regulation of human suppressor cell function by thymosin.
Suppressor cells were induced in vitro by Con. A using human peripheral blood lymphocytes. Suppressor cell function was evaluated by mitogen stimulation (PHA and Con. A) and in mixed lymphocyte culture (MLC), Thymosin fraction V was able to block the effector phase more significantly than the induction phase of suppressor cell expression. This effect was additive if thymosin fraction V was present both during the induction and effector phases.
D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology*; D013947:Thymosin / Q000502:physiology*; D013951:Thymus Hormones / Q000502:physiology*
D013951:Thymus Hormones; D003208:Concanavalin A; D013947:Thymosin