Terminal transferase-positive human bone marrow cells exhibit the antigenic phenotype of common acute lymphoblastic leukemia.
Combined immunologic assays for TdT enzyme and membrane markers show that TdT+ cells in nonleukemic human bone marrow carry ALL-associated and Ia-like antigens but no thymocyte markers or surface Ig. These cells could be precursors involved in acute lymphoblastic leukemia of the "common" or non-T, non-B type and in lymphoid blast crisis of Ph' positive chronic myeloid leukemia. A few TdT+, Ia+ cells express cytoplasmic IgM, indicating that some pre-B cells may be TdT positive.
D000941:Antigens; D001402:B-Lymphocytes / Q000201:enzymology; D001853:Bone Marrow / Q000201:enzymology* / Q000276:immunology; D001854:Bone Marrow Cells; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology* / Q000276:immunology; D009713:Nucleotidyltransferases; D010641:Phenotype; D013601:T-Lymphocytes / Q000201:enzymology
D000941:Antigens; D009713:Nucleotidyltransferases