title: Granulocyte adherence changes induced by hemodialysis, endotoxin, epinephrine, and glucocorticoids.
abstract: Granulocyte adherence was studied in several situations of altered granulycyte kinetics. During the transient granulocytopenia of hemodialysis, adherence increased to 481.7% of baseline by 15 min and was normal by 60 min. One hour after endotoxin administration, adherence was 160.5% of control as granulocyte counts fell to 21.4%; conversely, the 24-h postdose granulocytosis was associated with a 43.0% decrease in adherence. Epinephrine produced a 25.8% decrease in adhereence, with demargination granulocytosis 146.1% of control period. Alternate-day prednisone administration inhibited adhereence by 38.9% on the "on" day, concomitant with prolonged granulocyte intravascular half-life, but adherence returned to normal on the "off" day when intravascular half-life is normal. In each situation, a plasma factor not present in serum was responsible for the modified adherence; if these factors produce the sameadherence changes in vivo, they may be responsible for the alterations noted in granulocyte kinetics.
mesh_terms: D000380:Agranulocytosis / Q000097:blood; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D004926:Escherichia coli; D005260:Female; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D007964:Leukocytosis / Q000097:blood; D008297:Male; D011241:Prednisone / Q000494:pharmacology*; D011817:Rabbits; D006435:Renal Dialysis
chemical_list: D004731:Endotoxins; D011241:Prednisone; D004837:Epinephrine