Therapy for experimental intraabdominal sepsis: comparison of four cephalosporins with clindamycin plus gentamicin.
An experimental model of intraabdominal sepsis in rats was used for evaluation of treatment with four cephalosporins: cephalothin, cefazolin, cefoxitin, and cefamandole. Doses were 115 mg of each of the cephalosporins/kg and, in additional experiments, 350 mg of cephalothin or cefazolin/kg. Response to treatment was evaluated by mortality rate and the incidence of intraabdominal abscess. All four cephalosporins and gentamicin produced a similar reduction in mortality rates. There was a marked variation in incidence of abscess dependent upon the cephalosporin selected and the dosage tested. Regimens most effective in reducing abscesses were clindamycin, low-dose cefoxitin, or high-dose cephalothin.
D000005:Abdomen; D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D000818:Animals; D001441:Bacteroides fragilis / Q000302:isolation & purification; D002511:Cephalosporins / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000302:isolation & purification; D005673:Fusobacterium / Q000302:isolation & purification; D005839:Gentamicins / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D013291:Streptococcus / Q000302:isolation & purification
D002511:Cephalosporins; D005839:Gentamicins; D002981:Clindamycin