Distribution of identity of Thy-1-bearing cells during ontogeny in rat hemopoietic and lymphoid tissues.
The distribution and identity of Thy-1+ cells during ontogeny in the rat were examined by immunofluorescent and histologic techniques, and the relative amount of Thy-1 antigen on different cell types was assessed by quantitative absorption. Thy-1+ cells were subsequently studied by dual immunofluorescence for the simultaneous expression of either T or B lymphocyte markers. The results indicate that the Thy-1 antigen is present on hemopoietic precursors and on at least some of their lymphoid (both T and B) and nonlymphoid descendants. In addition, six serologically distinct subpopulations of lymphoid cells were identified, and their position in T and B cell maturational pathways is discussed.
D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007519:Isoantigens; D008099:Liver / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D011947:Receptors, Antigen, B-Cell; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D007519:Isoantigens; D011947:Receptors, Antigen, B-Cell