The environment in which lymphocytes differentiate influences their ability to cooperate in vivo.
Whether or not parental B lymphocytes cooperate with F1 T lymphocytes depends upon the environment in which parental bone marrow cells differentiate. Only those parental B lymphocytes that have differentiated in the F1 environment are able to cooperate with F1 T lymphocytes.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D005838:Genotype; D006084:Graft Rejection; D008211:Lymphocyte Cooperation; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology*