[Different effect of testosterone on polypotential stem hematopoietic stem cells and immunocompetent B-lymphocytes].
A research was made to study the dynamics of the proliferative, colony-forming and migration capacity of stem hemopoietic cells in (CBA X C57Bl) F1 hybrid mice under the influence of testosterone propionate, 10 mg/100 g, as well as the migration of immunocompetent B lymphocytes from the bone marrow to the spleen and the accumlation of their progeny, antibody-producing cells, in the spleen. The immunodepressive effect of testosterone was manifested by a decrease in the migration of B cells and the number of antibody-producing cells in the spleen. On the contrary, testosterone had a stimulating effect on the functional activity of stem hemopoietic cells, increasing their proliferation and migration. Under conditions of the suppressed erythropoietic differentiation of multipotent stem hemopoietic cells the injection of testosterone resulted in an increase in the number of antibody-producing cells in the spleen. This suggests that the stimulation of erythropoiesis and immunosuppression, induced by testosterone, are interconnected and determined by the direct action of the hormone on the cellular cycle of the stem cells, as well as by their prevailing differentiation towards the erythroid series, resulting in the decrease of their differentiation into B cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects; D012756:Sheep / Q000276:immunology; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone
Razlichnoe vliianie testosterona na polipotentnye stvolovye krovetvornye kletki i immunokompetentnye B-limfotsity.