Evidence of cell-mediated antitumor immunity in rats bearing syngeneic tumors by the leukocyte adherence inhibition test.
A modified form of the leukocyte adherence inhibition (LAI) test has been used to follow cell-mediated immunity (CMI) in rats of the Lewis inbred strain (LW), F1 hybrids inbred strains LW x AVN with transplanted syngeneic tumors B77, MC-1, and the random-bred Sprague Dawley strain with spontaneous REF tumor. Peripheral blood leukocytes of animals incubated witha specific tumor extract showed an adherence capacity by 30--40% lower than the same cell population cultured without this specific extract, or with a foreign nonspecific extract. The results are commented in connection with a possible application of this modified form of LAI test in studies of the immunological state of patients with a malignant disorder.
D000818:Animals; D000951:Antigens, Neoplasm / Q000008:administration & dosage; D005260:Female; D007111:Immunity, Cellular; D007957:Leukocyte Adherence Inhibition Test; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D012513:Sarcoma, Experimental / Q000276:immunology; D014185:Transplantation, Isogeneic
D000951:Antigens, Neoplasm