title: Bipartite structure of the ade3 locus of Saccharomyces cerevisiae.
abstract: Forty ade3 mutants were examined with respect to their growth requirements, levels of the tetrahydrofolate interconversion enzymes, and/or map positions. Four deletions were detected. Mutations that result in a requirement for adenine and histidine map in one region of the locus; those which result in a requirement for adenine only map in a quite separate region of the locus, a region not disclosed in previous studies. No correlation was observed between growth properties of the strains and enzyme levels.
mesh_terms: D000225:Adenine / Q000378:metabolism; D000483:Alleles; D000619:Aminohydrolases / Q000378:metabolism; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000378:metabolism; D009154:Mutation; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000648:ultrastructure*; D013763:Tetrahydrofolates
chemical_list: D013763:Tetrahydrofolates; D006639:Histidine; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D012696:Glycine Hydroxymethyltransferase; D000619:Aminohydrolases; D005574:Formate-Tetrahydrofolate Ligase; D000225:Adenine