[Effect of nootropil and contvykal on the structural changes in the central nervous system in hypoxic brain edema].
The brain cortex of rabbits exposed to 15-minute ishemia in the presence of monitored hypotonia was studied in 27 experiments in order to verify the efficacy of nootropil and contrykal as agents intended for the treatment of posthypoxic edema of the brain. The therapeutic efficacy was assessed on the basis of the evidence obtained with the aid of light and electron microscopy. It was found that nootropil exerts a favourable action on the ultrastructure of intracellular organella of the neuron: mitochondria, lysosomes, ribosomal apparatus, nuclear envelope, etc. Under the effect of nootropil and contrykal the posthypoxic microcirculatory changes showed signs of compensation and proved reversible. Manifestations of posthypoxic edema of the brain were less pronounced. It is suggested that the efficacy of the treatment regimen offered is related to the normalizing effect of nootropil on metabolic and repair processes in neurons and cellular elements pertaining to the microcirculatory system as well as with a direct action of contrykal on the local factors of capillary permeability.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001929:Brain Edema / Q000188:drug therapy* / Q000473:pathology; D002490:Central Nervous System / Q000187:drug effects* / Q000648:ultrastructure; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000188:drug therapy* / Q000473:pathology; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D011817:Rabbits
D011760:Pyrrolidinones; D007611:Aprotinin; D010889:Piracetam
Vliianie nootropila i kontrikala na strukturnye izmeneniia v tsentral'noĭ nervnoĭ sisteme pri gipoksicheskoĭ oteke mozga.