[Muscle metabolic state in tourniquet syndrome in the rat after administration of the proteinase inhibitor aprotinin (author's transl)].
The metabolic status of rat skeletal muscle was examined after 5 h of unilateral ischemia of one hind leg and following 5 h of recirculation. There was no recovery, neither with nor without aprotinin (Trasylol) in different doses (35 000 and 125 000 KIE/kg b.w.). After 3 h of ischemia and 3 h of recirculation a significant recovery of the metabolic status occurred in animals without and with 35 000 KIE aprotinin/kg b.w. After injection of 125 000 KIE aprotinin the restoration of the metabolic status was significantly retarded. The metabolic situation of the contralateral, non-ischemic legs revealed--in comparison to normal levels--a significant deterioration in the latter group.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D007511:Ischemia / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014111:Tourniquets
D007611:Aprotinin
Muskelstoffwechselstatus beim Tourniquet-Syndrom der Ratte nach Anwendung des Proteinaseninhibitors Aprotinin.