Return of function in the thrombosed kidney after transplantation.
The incidence of intraglomerular thrombi in renal allografts and factors regulating their resolution were studied. A case report is presented in which resolution of intraglomerular thrombi is documented. In addition, 17 transplanted patients with renal biopsies were serially studied. Intraglomerular thrombi were found in 4 of 8 specimens taken 1 h after reanastamosis, all from donors with a terminal course involving prolonged hypotension. Glomerular fibrinolytic activity was markedly diminished in 4 of 11 patients' subsequent biopsy specimens; all taken during acute rejection. Resolution of thrombi was documented when signs of rejection were absent.
D000328:Adult; D005260:Female; D005342:Fibrinolysis; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000502:physiology; D016030:Kidney Transplantation; D013927:Thrombosis / Q000150:complications*