[Simultaneous improvement of mood and release of growth hormone by L-5-hydroxytryptophan (Ro 3-5940) in normal subjects (author's transl)].
Infusion of a new soluble ester of L-5-hydroxytryptophan produced euphoria in 34/35 experiments in healthy subjects. Parallel measurements of growth hormone and mood changes showed a similar rise and fall of these two parameters in 8/11 subjects. These results indicate that central stimulatory serotoninergic mechanisms (in addition to the well-known dopaminergic and alpha-adrenergic stimulation) play a role in the control of growth hormone release.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects*; D005059:Euphoria / Q000187:drug effects; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D013997:Time Factors
D013006:Growth Hormone; D006916:5-Hydroxytryptophan
Gleichzeitige Stimmungshebung und Ausschüttung von Wachstumshormon durch L-5-Hydroxytryptophan (Ro 3-5940) bei gesunden Personen.