Detection of metastatic tumors in nude mice: brief communication.
Homozygous nude (nu/nu) mice were inoculated ip with either highly malignant human bladder transitional cell carcinoma or human prostate adenocarcinoma. These animals were subsequently given injections of normal human T-lymphocytes to restore the known T-lymphocyte deficiency present in homozygous nude mice. Metastatic spread of the prostate and bladder carcinomas was evident in mice given human T-lymphocytes. Although tumor growth was observed at the sites of tumor inoculation, no tumor spread was observed in mice not receiving T-lymphocytes.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology; D013601:T-Lymphocytes / Q000502:physiology* / Q000637:transplantation; D014183:Transplantation, Heterologous; D001749:Urinary Bladder Neoplasms / Q000473:pathology