Effect of inhibitors of prostaglandin synthesis and metabolism on ovum transport in the rabbit.
Several drugs known to affect prostaglandin synthesis, release, or metabolism have been tested for their effects on ovum transport in the rabbit after systemic or local administration. Acceleration of transport was obtained with several drugs; among the most effective were benzydamine, a blocker of thromboxane production, and L11204, an inhibitor of prostaglandin metabolism.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D006051:Aurothioglucose / Q000494:pharmacology; D001591:Benzydamine / Q000494:pharmacology; D003864:Depression, Chemical; D004958:Estradiol / Q000494:pharmacology; D005187:Fallopian Tubes / Q000187:drug effects; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D008469:Meclofenamic Acid / Q000494:pharmacology; D010066:Ovum Transport / Q000187:drug effects*; D010653:Phenylbutazone / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007546:Isoquinolines; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D014230:Triazoles; D006051:Aurothioglucose; D008469:Meclofenamic Acid; D001591:Benzydamine; D004958:Estradiol; D012110:Reserpine; D010653:Phenylbutazone; D006854:Hydrocortisone