Collagen and non-collagen protein synthesis in developing lung exposed to tobacco smoke.
The present investigation was conducted to determine the rate of collagen and non-collagen protein synthesis by rat lung under in vitro conditions. The rate of synthesis of non-collagen protein was greater than the rate of collagen synthesis in animals between 1 and 95 days of age. Synthesis of both types of proteins was highest in 1-day-old animals. Rate of synthesis of non-collagen protein was markedly diminished after 7 days of age and that of collagen decreased after 14 days. Per gram lung, the total amount of collagen increased 3.5-fold between Day 7 and 95 whereas total protein was relatively constant. When lung was exposed to smoke under in vitro conditions synthesis of collagen and non-collagen protein was almost completely depressed.
D000367:Age Factors; D000818:Animals; D003094:Collagen / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D004247:DNA / Q000032:analysis; D004781:Environmental Exposure; D006801:Humans; D007629:Kentucky; D007700:Kinetics; D008168:Lung / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking / Q000009:adverse effects*
D003094:Collagen; D004247:DNA