Quantitative microscopic studies of the distribution and retention of 239Pu in the ilium of the female CBA mouse.
Three month old female CBA mice were injected with 50 nCi kg-1 body mass of minimally polymeric 239Pu-citrate and killed at 24 hours, 10 days, 1 month and 3 months after injection. The distribution of 239Pu in the ilia of these mice was analysed using neutron-induced autoradiography of bone sections together with computer-based methods of data reduction. Results of these investigations demonstrate that while 239Pu is initially localized on bone surfaces, by 3 months after injection it is fairly uniformly distributed throughout mineral bone and its included marrow.
D000818:Animals; D001345:Autoradiography; D001853:Bone Marrow / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D007085:Ilium / Q000378:metabolism; D007275:Injections, Intravenous; D008722:Methods; D051379:Mice; D008808:Mice, Inbred CBA; D011005:Plutonium / Q000378:metabolism* / Q000494:pharmacology; D013997:Time Factors
D011005:Plutonium