Blood DDS levels and acetylation rates of sulphadimidine in leprosy patients.
The plasma DDS clearance rates and the acetylation rates of Sulphadimidine were studied in a group of 30 leprosy patients comprising of 17 non-responders and 13 responders to DDS treatment. No differences in the acetylator type or in the plasma DDS clearance were seen between the responders and non-responders. Acetylation rate did not bear any relation to the plasma clearance of DDS in the non-responders. The findings indicate that the resistance to DDS therapy in these patients is not related to any abnormal metabolic disposition of DDS.
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D003622:Dapsone / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007918:Leprosy / Q000097:blood* / Q000188:drug therapy; D008297:Male; D009166:Mycobacterium leprae / Q000187:drug effects; D013418:Sulfamethazine / Q000097:blood / Q000378:metabolism* / Q000652:urine
D013418:Sulfamethazine; D003622:Dapsone