Inhibition of B cell cytotoxicity by aggregated IgG and immune complexes.
The presence of immune complexes or aggregated IgG in the microlymphocytotoxicity assay may cause inhibition of cytoxity. When HLA-A and-B antigens are the subject of the test the effect is minimal; however, when B cell alloantigens are being examined the effect is marked. The pattern of inhibition in the later case and the fact that B lymphocytes preincubated with immune complexes are resistant to cytotoxic lysis by anti-B cell sera suggests that immune complexes and aggregated IgG inhibit cytotoxicity by prevention of antibody binding rather than by complement consumption.
D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G
D000936:Antigen-Antibody Complex; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G