title: Ototoxicity in neonates treated with gentamicin and kanamycin: results of a four-year controlled follow-up study.
abstract: This article reports the results of a four-year follow-up study initiated in 1970 on the long-term effects of gentamicin and kanamycin use in newborn infants. Audiometric, vestibular, and psychometric evaluations were performed on gentamicin-treated, kanamycin-treated, and untreated, matched control infants and children. No substantial sensorineural hearing loss or vestibular dysfunction was identified in these patients that could be attributed to aminoglycoside therapy. Performances on the Illinois Test of Psycholinguistic Abilities, Beery Test of Visual Motor Integration, the Peabody Picture Vocabulary Test, and on fine and gross motor examinations were comparable for the three study groups.
mesh_terms: D001299:Audiometry; D001424:Bacterial Infections / Q000188:drug therapy; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000009:adverse effects* / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy; D007612:Kanamycin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011581:Psychological Tests; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects*
chemical_list: D005839:Gentamicins; D007612:Kanamycin