title: Vestibular-optokinetic interactions in normal subjects and in patients with peripheral vestibular dysfunction.
abstract: The vestibulo-ocular reflex (VOR) during rotation, optokinetic nystagmus (OKN), and interactions between the vestibulo-ocular and optokinetic systems were studied quantitatively in 10 normal human subjects, 15 patients with unilateral horizontal semicircular canal paralysis (UP), and 11 patients with bilateral horizontal semicircular canal paralysis (BP). The OKN gain (eye velocity/drum velocity) was not significantly different between the normal subjects and the patient groups. During tests in which rotatory and visual stimuli were presented simultaneously, the contribution to the observed eye movements by the VOR was only one-fourth to one-third of its gain during rotation in the dark in the normal subjects and UP patients. These interactive tests did not differentiate UP patients from normal subjects but did separate BP patients from normal subjects.
mesh_terms: D000328:Adult; D005133:Eye Movements; D006801:Humans; D007759:Labyrinth Diseases / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D012665:Semicircular Canals / Q000503:physiopathology; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000502:physiology* / Q000503:physiopathology