Attempts to evaluate the role of the third complement component (C3) and complement receptor lymphocytes (CRL"+") in the induction of the humoral immune response.
It has been shown that spleen and bone marrow complement receptor lymphocytes (CRL"+") are responsible for T-dependent anti-SRBC response. This has been shown by comparison of the T-dependent anti-SRBC and T-independent anti-SIII response in irradiated mice repopulated with normal or CRL depleted spleen cell populations. Unseparated spleen cells obtained from animals immunized 48 h before with SRBC, and CRL depleted cell population from animals receiving T-independent antigens (levan, SIII) were shown to be predominantly stimulated when uptake of isotope labelled leucine or tymidine was studied. It was also shown that triggering of enhanced antibody production by T cell derived signal generated during GvH reaction is C3 dependent.
D000818:Animals; D000917:Antibody Formation; D001665:Binding Sites; D003176:Complement C3 / Q000502:physiology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D011828:Radiation Chimera; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M