Effects of increasing serotonergic receptor activity in brain on prostagladin E1-induced fever in rabbits.
In rabbits, increasing serotonergic receptor activity or funtional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate the brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001545:Benserazide / Q000008:administration & dosage / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002997:Clomipramine / Q000008:administration & dosage / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced / Q000378:metabolism*; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D011458:Prostaglandins E; D011817:Rabbits; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D011458:Prostaglandins E; D011985:Receptors, Serotonin; D005473:Fluoxetine; D012701:Serotonin; D001545:Benserazide; D006916:5-Hydroxytryptophan; D002997:Clomipramine