Pathogenesis of pemphigus erythematosus.
Immunofluorescence studies were made by the indirect method in 54 cases of pemphigus erythematosus, in 50 of which skin specimens from light-exposed and unexposed regions were investigated also by the direct IF method. IF Band was shown to be demonstrable in skin specimens from exposed regions in 81% of cases and from unexposed regions in 23%. ANA were found in some 31% of patients, though usually in titers below those of IC antibodies. There were 2 cases each of coexistence with myastenia gravis and thymoma and with SLE. Virus-like particles, however, were found by electron microscopy only in 1 case with coexisting SLE. Detection of IF Band in skin specimens from a significant majority of patients with pemphigus erythematosus, presence of ANA in some, and occasional coexistence of SLE suggest some relation of the disease with lupus erythematosus.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000276:immunology / Q000503:physiopathology*; D012867:Skin / Q000032:analysis; D013577:Syndrome
D000974:Antibodies, Antinuclear