[Antitumor activity of fatty acid derivatives isolated from protozoa].
Water-soluble monoethers of sucrose and fatty acids were obtained from Trypanosoma lewisi and Astasia longa. The maximum tolerated dose of the preparations on their single intraperitoneal administration was more than 25 g/kg. The doses of 10--40 mg/kg were used repeatedly in therapy. Carcinoma 755, Lewis carcinoma, sarcoma 45, sarcoma 37 and sarcoma 180 were sensitive to the preparations. The preparations were inactive against experimental leukemia.
D000818:Animals; D000970:Antineoplastic Agents; D002277:Carcinoma / Q000188:drug therapy; D002458:Cell Fractionation; D004341:Drug Evaluation; D004952:Esters; D056890:Eukaryota; D005227:Fatty Acids / Q000302:isolation & purification* / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D012995:Solubility; D014350:Trypanosoma lewisi
D000970:Antineoplastic Agents; D004952:Esters; D005227:Fatty Acids
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