Deficiency of T and B lymphocytes in uremic subjects and partial improvement with maintenance hemodialysis.
Lymphopenia of a group of uremic patients was associated with normal percentages of T cells but reduced percentages of B cells. Lymphocyte counts improved after a period of maintenance hemodialysis, although not to control levels, and B cell percentages returned towards normal. Uremia is therefore associated with depression of total T and B cell numbers, with a relatively more pronounced effect on B cells. A period of maintenance hemodialysis produces increase in numbers of both cell types and depression becomes nonselective.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013601:T-Lymphocytes; D014511:Uremia / Q000097:blood*