Intestinal goblet cell differentiation in Nippostrongylus-infected rats after transfer of fractionated thoracic duct lymphocytes.
Adoptive immunization of Nippostrongylus-infected rats augmented goblet cell differentiation in the intestinal epithelium. After fractionation of immune thoracic duct lymphocytes (TDL), cells lacking surface immunoglobulin (sIg-) were the most potent stimulators of goblet cell differentiation. Moreover, TDL drained from rats harbouring a primary infection were more effective than TDL from hyperimmune rats.
D000818:Animals; D002454:Cell Differentiation; D002469:Cell Separation; D005260:Female; D007114:Immunization; D007116:Immunization, Passive; D007413:Intestinal Mucosa / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology*; D009349:Nematode Infections / Q000276:immunology* / Q000473:pathology; D009559:Nippostrongylus; D051381:Rats; D011947:Receptors, Antigen, B-Cell; D013601:T-Lymphocytes / Q000276:immunology
D011947:Receptors, Antigen, B-Cell