Effect of mefloquine on the immune response in mice.
The effect of mefloquine, a new antimalarial compound, on the immune response in mice was studied in vitro and in vivo. Slight inhibition of mitogen-induced lymphocyte proliferative responses was observed at a concentration of 1 microgram/ml, and marked cytotoxicity at 4 microgram/ml. In contrast, a higher proportion of human lymphocytes remained viable at the same concentration of mefloquine. Antibody responses to sheep erythrocytes were impaired in mice receiving a total dose of 60 mg/kg. At this dosage schedule, delayed-type hypersensitivity responses to the same antigen were not affected.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000962:Antimalarials / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D015767:Mefloquine; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*
D000962:Antimalarials; D008934:Mitogens; D010880:Piperidines; D011804:Quinolines; D015767:Mefloquine