title: Comparative physiology of the renin-angiotensin system.
abstract: Renin or a renin-like substance is found in the kidneys of many vertebrate species. It is absent from the kidneys of cyclostomes and elasmobranchs and first appears in holosteans and the bony fishes as well as in all higher vertebrate species. Juxtaglomerular cell granules also appear first in holosteans and the bony fishes while the macula densa first appears in amphibians. In telecost fishes, the corpuscles of Stannius contain Bowie-stainable granules and a renin-like pressor substance. Among classes and, in some cases, species of vertebrates, specificity in the reaction of renin with a substrate has been demonstrated. There is also some species and class variation in the angiotensin molecule since angiotensins of fishes, amphibians, reptiles and birds have chemical characteristics different from each other and from those of ammmals. A role for renin in stimulating interrenal gland steroid biosynthesis and in influencing water and ion regulation in nonmammalian vertebrates is discussed.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D001794:Blood Pressure; D001921:Brain / Q000201:enzymology; D005260:Female; D005399:Fishes / Q000502:physiology; D007606:Juxtaglomerular Apparatus / Q000166:cytology / Q000502:physiology*; D007668:Kidney / Q000502:physiology; D008322:Mammals / Q000502:physiology; D012083:Renin / Q000502:physiology*; D012469:Salivary Glands / Q000201:enzymology; D013045:Species Specificity; D014599:Uterus / Q000201:enzymology; D014882:Water-Electrolyte Balance
chemical_list: D000305:Adrenal Cortex Hormones; D000804:Angiotensin II; D012083:Renin