title: Mutagenicity of benzidine and related compounds employed in the detection of hemoglobin.
abstract: Seven compounds commonly used as chromagens for the detection of hemoglobin and its derivatives have been assayed for mutagenicity employing the Salmonella/mammalian microsome test. Three of these compounds, benzidine, o-dianisidine, and o-tolidine, were shown to be mutagenic. Since benzidine and o-tolidine are already known to be carcinogens, there is a high probability that o-dianisidine will also prove to be a carcinogen. Four compounds tested with this system, o-anisidine, diphenylamine, guaicol, and o-toluidine, were not mutagenic.
mesh_terms: D000818:Animals; D001560:Benzidines / Q000633:toxicity*; D002876:Chromosomes, Bacterial / Q000187:drug effects*; D004159:Diphenylamine / Q000633:toxicity; D006139:Guaiacol / Q000633:toxicity; D006454:Hemoglobins / Q000032:analysis*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D014052:Toluidines / Q000633:toxicity
chemical_list: D001560:Benzidines; D006454:Hemoglobins; D009153:Mutagens; D014052:Toluidines; D006139:Guaiacol; D004159:Diphenylamine