title: Trans-dominance of dnaA mutants in Escherichia coli.
abstract: Temperature sensitivity of growth and DNA synthesis was tested in merogenotes heterozygous for the dnaA allele. All combinations tested (F dnaA+/dnaA5, F dnaA+/dnaA46, F dnaA+/dnaA204, F dnaA5/dnaA+, F dnaA204/dnaA+) were temperature sensitive. The mutant dnaA allele is thus trans-dominant to the wild type allele.
mesh_terms: D000483:Alleles; D004269:DNA, Bacterial; D004926:Escherichia coli / Q000254:growth & development; D005799:Genes, Dominant; D005816:Genetic Complementation Test; D006579:Heterozygote; D009154:Mutation; D013696:Temperature
chemical_list: D004269:DNA, Bacterial