Effect of alloxan on rat pancreatic polypeptide (PP) cells.
Injection of alloxan caused an almost total disappearance of insulin cells in the rat pancreas. Planimetric analysis revealed a 50 per cent reduction of the mean islet volume. The number of immunoreactive pancreatic polypeptide (PP) cells per sectioned islet was significantly increased, and the PP cell volume per islet doubled. Assuming an unchanged number of islets, the results indicate an increase in total PP cell mass following alloxan administration.
D000818:Animals; D002452:Cell Count; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D007515:Islets of Langerhans / Q000032:analysis / Q000473:pathology*; D008297:Male; D010187:Pancreatic Hormones / Q000032:analysis*; D010455:Peptides / Q000032:analysis; D051381:Rats
D010187:Pancreatic Hormones; D010455:Peptides