Studies of surface immunoglobulins on human B lymphocytes. III. Physiological variations of SIg+ cells in peripheral blood.
The levels of B lymphocytes bearing surface immunoglobulins in human peripheral blood were measured by immunofluorescence after pre-treatment of the cells with a low pH shock or washing at 37 degrees C. It was found that the percentages of SIg-bearing cells in an individual varied throughout the day and showed a circadian rhythm with a peak at 12 midnight and a depression at 12 noon. In addition, the levels of the B lymphocytes in the peripheral blood were shown to vary annually, being lower in the winter than in the summer.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D002940:Circadian Rhythm; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D012621:Seasons
D011947:Receptors, Antigen, B-Cell