Restoration by levamisole of histamine-inhibited E rosette formation of T lymphocytes of patients with allergies.
Histamine significantly inhibited the E rosette formation of T lymphocytes of patients with allergies in vitro, but had no effect on the E rosette formation of T lymphocytes of healthy subjects. This inhibitory effect was obtained by concentrations of 3.10(-4) down to 3.10(-7) M histamine and depended on the time of incubation. Levamisole an antianergic chemotherapeutic agent, could restore the histamine-inhibited E rosette formation. It is postulated that patients with allergies possess a subpopulation of T lymphocytes bearing histamine receptors and that the inhibitory effect of histamine on E rosette formation is medicated by intracellular cAMP.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007158:Immunologic Techniques; D007223:Infant; D007978:Levamisole / Q000494:pharmacology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D013696:Temperature; D013997:Time Factors
D007978:Levamisole; D006632:Histamine