[Oncogenic virus induction by halogenated pyrimidines (author's transl)].
Oncongenic DNA and RNA Viruses are integrated into the cell genome of vertebrates. Physical, chemical and biological agents, among them the halogenated pyrimidines ododeoxyuridine (IdU) and bromodeoxyuridine (BdU) cause the induction of these viruses in cells of many species. In this review the action of IdU and BdU in certain cell differentiation systems chondrogenesis, myogenesis and others) and on activation of oncogenic viruses, first of all of type C-RNA viruses, is described and some possible mechanisms of induction are discussed.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002356:Cartilage / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005838:Genotype; D007065:Idoxuridine / Q000494:pharmacology*; D009132:Muscles / Q000166:cytology; D009858:Oncogenic Viruses; D012328:RNA Viruses; D013045:Species Specificity
D001973:Bromodeoxyuridine; D007065:Idoxuridine
Ubersicht Induktion onkogener Viren durch Halogenderivate der Pyrimidine.