[6-(2,4-Dinitrophenyl)-mercaptopurine, a stronger immunosuppressive drug than 6-mercaptopurine to primary humoral T-cell dependent immune response in mice].
The suppressive effect of 6-(2,4-Dinitrophenyl)-mercatopurine (DNP-MP) and 6-mercaptopurine (MP) was investigated on the early primary immune response of mice against the T-cell dependent antigens DNP49-bovine gamma globuline (BGG), sheep red blood cells (SRBC) or FITC8-BCG and the T-cell independent DNP22-Ficoll. The number of IgM antibody forming cells (AbFC) to the hapten determinants and to the SRBCs per 10(6) spleen cells was determined. DNP-MP reduced the number of AbFCs after the immunisation with the T cell dependent antigens always stronger than the MP, independently of the antigen type by which the mice had been immunised. The Anti-DNP22-Ficoll immune response was suppressed equally by both immunosuppressive drugs. DNP-MP is not a specific immunosuppressive drug for the anti-DNP-B-lymphocytes. Helper T-cells and macrophages are discussed as target cells for the stronger unspecific action of DNP-MP.
D000818:Animals; D000917:Antibody Formation; D004136:Dinitrobenzenes / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005362:Ficoll; D006241:Haptens; D007165:Immunosuppression Therapy; D015122:Mercaptopurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D004136:Dinitrobenzenes; D006241:Haptens; D005362:Ficoll; D015122:Mercaptopurine
6-(2,4-Dinitrophenyl)-merkaptopurin -- ein stärkeres Immunsuppressivum als 6-Merkaptopurin für primäre humorale T-Zell-abhängige Immunreaktionen der Maus.