Metabolic effects of fenfluramine in obese diabetics.
1 In a single-blind, cross-over study fenfluramine in a daily dose of 120 mg was found to reduce the daily blood glucose level moderately in hospitalized obese diabetics treated with a 1200 calorie diabetic diet. 2 After 7 days of treatment, fenfluramine was found not to influence the intravenous glucose tolerance, the insulin response to intravenously administered glucose, or the growth hormone  response to arginine. 3 No changes in blood levels of lactate, beta hydroxybutyrate, triglycerides or cholesterol were seen during fenfluramine treatment.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007773:Lactates / Q000097:blood; D008875:Middle Aged; D009765:Obesity; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D006885:Hydroxybutyrates; D007773:Lactates; D014280:Triglycerides; D005277:Fenfluramine; D013006:Growth Hormone; D002784:Cholesterol