[Treatment of renal osteodystrophy: physiopathology and secondary effects].
The prophylaxis and treatment of renal osteodystrophy are based on pathophysiological principles. Development of secondary hyperparathyroidism should be averted by early prevention of hyperphosphatemia through diet and phosphate ligants, and by normalization of the calcium balance through calcium supplements and vitamin D or its analogues. This treatment requires close clinical and laboratory control in order to avoid several hazards (hypercalcemia, hypophosphatemia, and refractory constipation). In cases with severe secondary hyperparathyroidism, subtotal parathyroidectomy is sometimes required. Nevertheless, in one such case this operation resulted in sudden hypoparathyroidism two years postoperatively.
D000536:Aluminum Hydroxide / Q000009:adverse effects / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000009:adverse effects / Q000627:therapeutic use; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy* / Q000601:surgery; D003248:Constipation / Q000139:chemically induced; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous; D014807:Vitamin D / Q000627:therapeutic use
D014807:Vitamin D; D000536:Aluminum Hydroxide; D002119:Calcium Carbonate
Traitement de l'ostéodystrophie rénale: pathophysiologie et effets secondaires.