Antitumor effect of whole-body X-irradiation: possible role of an X-ray-sensitive T suppressor cell population.
Findings have been presented which support the concept that SBF and suppressor cells can modify immune responses to tumor antigens in vivo, and they indicate that some types of SBF act through a radiosensitive suppressor cell system. We believe that further understanding of the mechanisms involved will provide methods of manipulating the immune response to certain immunogenic tumors and may thereby help in the development of tumor immunotherapy.
D000818:Animals; D000951:Antigens, Neoplasm; D007109:Immunity / Q000528:radiation effects*; D007165:Immunosuppression Therapy; D051379:Mice; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014965:X-Rays
D000951:Antigens, Neoplasm