Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in renal failure.
Factor VIII/von Willebrand factor antigen and von Willebrand factor activity (ristocetin assay) were studied in 12 patients in renal failure. A dramatic increase in both activities was observed (antigen 315 +/- 30 per cent in patients verus 104 +/- 9 per cent in control subjects; activity 402 +/- 48 per cent in patients versus 111 +/- 5 per cent in control subjects; p less than 0.001 for both). Since von Willebrand factor is thought to play at least a facilitative role in the development of arteriosclerosis, these increased activities may contribute to the premature arteriosclerosis reported in patients with chronic renal failure undergoing dialysis.
D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005169:Factor VIII / Q000032:analysis*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D006435:Renal Dialysis; D014841:von Willebrand Factor / Q000032:analysis*
D001779:Blood Coagulation Factors; D014841:von Willebrand Factor; D005169:Factor VIII; D003404:Creatinine