Antinuclear antibodies in ankylosing spondylitis, psoriatic arthritis, and psoriasis.
Granulocyte-specific antinuclear antibodies (GS-ANA) were detected in the sera of 5 of 88 patients with ankylosing spondylitis (AS) and in 7 of 52 cases of psoriatic arthritis (PsA), but were not found in 91 patients with malignant or non-malignant chest disease nor in 25 cases of psoriasis. Organ non-specific ANA were present in serum from 6 cases of AS and 1 of PsA. None of the sera gave significant levels for soluble immune complexes as detected by a C1q-binding assay. The presence of antinuclear antibodies was not associated with clinical features or drug therapy in either AS or PsA.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D001168:Arthritis / Q000209:etiology / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D011565:Psoriasis / Q000150:complications / Q000276:immunology*; D013167:Spondylitis, Ankylosing / Q000276:immunology*
D000974:Antibodies, Antinuclear