[Comparative assessment of the properties of a factor inhibiting macrophage migration and interferon].
The authors investigated some functional properties of interferon and the macrophages migration inhibitory factor (MIF) obtained by stimulation of human tonsil lymphocytes with the virus of Newcastle disease (NDV) or O-streptolysin. Both the interferon and MIF inhibited actively the migration of human tonsil cells, but differed by the anti-viral activity, and sensitivity to heating at 56 degrees C for 30 min. Stimulation of human tonsil lymphocytes with NDV leads to production of a more wide range of delayed hypersensitivity mediators than stimulation with O-streptolysin.
D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology*; D014066:Palatine Tonsil; D014779:Virus Replication / Q000187:drug effects*
D008263:Macrophage Migration-Inhibitory Factors; D007372:Interferons
Sravnitel'nais otsenka svoĭstv faktora, ingibiruiushchego migratsiiu makrofagov, i interferona