title: The influence of prophage lambda on the mutagenic response of Escherichia coli to ultraviolet irradiation.
abstract: E. coli K-12 and its lambda-lysogenic derivative were used to study the influence of lysogenic induction on the induction of mutants (streptomycin sensitivity to streptomycin resistance) by UV irradiation. The lambda-lysogenic strain responded to UV irradiation with increased sensitivity and with a strong reduction of the absolute mutant quantity, recovered per UV dose, as compared with the non-lysogenic parental strain. However, similar mutant freqqencies per surviving bacterium exclude the possibility that the diminished mutant recovery results from a selective killing of mutant cells by simultaneous induction of the processes of mutation and lysis.
mesh_terms: D003090:Coliphages; D004307:Dose-Response Relationship, Radiation; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects*; D005787:Gene Frequency; D008242:Lysogeny; D009154:Mutation; D010641:Phenotype; D013307:Streptomycin / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D013307:Streptomycin