[Portal blood flow in minipig and its change by nicotinic acid (author's transl)].
The chronic double catheterisation of portal vein permits estimation of portal flow by dye dilution for example, the withdrawal of blood from the mesenteric vein and proximal portal vein, the injection of drugs into the portal circulation and measurement of portal pressure simultaneously. Beside the well known diminution of portal flow by vasopressin, which is extreme in anaesthetised minipig, there could be shown a remarkable diminution by high intravenous doses of nicotinic acid too without significant changes of systemic blood pressure and heart rat. Nicotinic acid causes also a diminution of pH in portal and venous blood.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004395:Dye Dilution Technique; D009539:Nicotinic Acids / Q000494:pharmacology*; D011168:Portal System / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D013552:Swine; D014667:Vasopressins / Q000494:pharmacology
D009539:Nicotinic Acids; D014667:Vasopressins
Die Pfortaderdurchblutung und deren Beeinflussung durch Nikotinsäure beim Miniaturschwein