title: Immune responsiveness of irradiated mice reconstituted with complement receptor positive CLR+ or negative CLR--lymphocytes from spleen or bone marrow.
abstract: Spleen and bone marrow cells depleted of CRL cannot restore immune reactivity of irradiated mice to sheep red blood cells SRBC. The response to anti-SIII, a T-independent antigen does not change when irradiated animals are repopulated with spleen cells or spleen cells depleted of CRL. Spleen cells of 6-day-old mice having low number of CRL, in contrast to spleen cells of adult animals, could not reconstitute irradiated recipients.
mesh_terms: D000367:Age Factors; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D001854:Bone Marrow Cells; D003176:Complement C3 / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D066298:In Vitro Techniques; D051379:Mice; D011951:Receptors, Complement / Q000276:immunology* / Q000528:radiation effects; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens; D003176:Complement C3; D011951:Receptors, Complement