[Synthesis and pharmacologic activity of benzothiopyranopyrazole and benzothiopyranoisoxazole carboxamides].
A series of carboxamides of benzotiopyranopyrazoles and benzothiiopyranoisoxazoles was synthesized starting from benzothiopyran-4-one-3-methylglyoxylates through two synthetic methods and tested for anti-inflammatory, analgesic and cardiovascular activity. Some of these compounds display pronounced antiarrhythmic activity.
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats
D000577:Amides; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D007555:Isoxazoles; D011720:Pyrazoles
Sintesi ed attività farmacologica di carbossiammidi di benzotiopiranopirazoli e benzotiopiranoisossazoli.