[Relationship between the presence of K- and O-antigens and the behavior of salmonellae in a culture of macrophages].
It was shown on experimental models (mice and in kerato-conjunctival reaction) in comparative study of spontaneous stable salmonella mutants that disturbances in the process of synthesis of K- or O-antigens led to the weakening or the loss of the bacterial virulence. In the study of the behavior of the salmonella mutants it was revealed in the culture of phagocytizing macrophages that a reduction of the cytotoxic action of bacteria was connected with the changes of the somatic O-antigen, whereas the capacity of salmonella to reproduction inside the macrophages correlated with the presence of surface K-antigen.
D000818:Animals; D000942:Antigens, Bacterial; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D006168:Guinea Pigs; D007637:Keratoconjunctivitis / Q000209:etiology; D008264:Macrophages; D051379:Mice; D009154:Mutation; D010587:Phagocytosis; D012475:Salmonella / Q000276:immunology / Q000472:pathogenicity*; D012484:Salmonella paratyphi B / Q000472:pathogenicity; D012486:Salmonella typhimurium / Q000472:pathogenicity; D014774:Virulence
D000942:Antigens, Bacterial
Povedenie sal'monell v kul'ture makrofagov v zavisimosti ot nalichiia K- i O-antigenov