Chloramphenicol and phenobarbitone--a drug interaction.
Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.
D002701:Chloramphenicol / Q000037:antagonists & inhibitors* / Q000097:blood / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000188:drug therapy; D010634:Phenobarbital / Q000494:pharmacology* / Q000627:therapeutic use
D002701:Chloramphenicol; D010634:Phenobarbital