[Structural organization of the antigen-binding receptors of immunocompetent cells].
It was demonstrated in this work that rabbit antimouse serum against the aggregated immunoglobulins (RAAS) and mouse serum against the aggregated mouse immunoglobulins (MAAS) inhibited the rosette-forming B-cells (RFC) on the 5th day after the immunization of mice CBA with SRBC in a dose of 5 X 10(-8) cells in vitro in 1:20--1:80, and 1:10--1:40 dilutions in 83--55 and 72--39%, respectively. In difference from RAAS, MAAS in a dilution of 1:20 induced a statistically significant suppression of the antigen-binding receptors of RFC of-B type in the intact animals, and on the 8th--9th day after their immunization with SRBC. In vivo MAAS induced inactivation of the antigen-binding receptors of B-lymphocytes only. Results of the work carried out served as a confirmation of the fact that immunoglobulins in the form of an antigen-antibody complex (functioning in the capacity of the antigen-binding receptors) were sorbed on B-lymphocytes of the spleen.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D011817:Rabbits / Q000276:immunology; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology*
O strukturnoĭ organizatsii antigensviazyvaiushchikh retseptorov immunokompetentnykh kletok.