Specific modulation of brain stimulation reward by haloperidol.
Low doses of haloperidol (3--18 micrograms/kg) caused dose related increases in reinforcing thresholds for self-stimulation to the medial forebrain bundle in rats. These effects, which were demonstrated completely independent of performance variables, indicate a direct modulation of central reinforcement processes by this drug, at doses which have highly selective action on dopaminergic neurotransmission.
D000818:Animals; D001921:Brain / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D051381:Rats; D012201:Reward; D012653:Self Stimulation / Q000187:drug effects*
D006220:Haloperidol