[Immunologic studies of lymph nodes in patients with maxillofacial tumors].
Starting from the basic concept that the regional lymph node, due to its important role in the defensive reaction to cancer, has a great value of information, the authors investigated 14 lymph nodes from patients with cancer in the maxillofacial region. The following immunological examinations were performed: T lymphocyte determination by means of the ovine erythrocyte rosette test; B lymphocyte determination by means of the mouse erythrocyte rosette test, with surface immunoglobulin estimation using the direct immunofluorescence technique; quantitative determination of immunoglobulins G, A and M in the lymph node extract. The results demonstrated that the determination of the absolute number of peripheral lymphocytes and of T rosettes as well as the immunoglobulin quantitation are very valuable. The decrease in T cells in the lymph node is obviously preceded by a similar development in the peripheral blood and seems to be a prognostic parameter. In lymph nodes in the maxillofacial region, a greater importance must be ascribed to IgA (as compared to the other immunoglobulins) than in other regions. The immunoreactivity against cancers in the maxillofacial region has a definite humoral component mainly determined by IgA. In addition to an increase in the number of samples examined by means of the aforementioned methods, parallel T cell determinations in the peripheral blood are advisable with regard to the evaluation by the influence of the cancer on the immunological system and for the purpose of prognostication.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005153:Facial Neoplasms / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology*; D051379:Mice / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell
Immunologische Untersuchungen von Lymphoknoten bei Patienten mit Tumoren im Kiefer-Gesichts-Bereich.