Enhancement by oleandomycin of the inhibitory effect of methylprednisolone on phytohemagglutinin-stimulated lymphocytes.
Triacetyloleandomycin (TAO) and its parent compound oleandomycin have a "steroid-sparing" effect in asthmatic patients. This study was designed to determine whether oleandomycin would enhance the inhibitory action of glucocorticosteroids in suppressing the blast transformation of phytohemagglutinin-stimulated human lymphocytes. Although oleandomycin could not be shown to inhibit the phytohemagglutinin stimulation of lymphocytes, there was a significant potentiation of steroid suppression at each concentration of methylprednisolone examined. This augmentation of glucocorticosteroid suppression of lymphocyte proliferation in vitro appears to support the clinically observed "steroid-sparing" effect of TAO and therefore its usefulness may not be limited to asthma and bronchitis.
D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D001991:Bronchitis / Q000188:drug therapy / Q000276:immunology; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008775:Methylprednisolone / Q000494:pharmacology*; D008875:Middle Aged; D009827:Oleandomycin / Q000494:pharmacology; D014217:Troleandomycin / Q000494:pharmacology*
D037102:Lectins; D014217:Troleandomycin; D009827:Oleandomycin; D008775:Methylprednisolone