[Therapy of low-output syndrome in patients following cardiopulmonary bypass with sodium nitroprusside and dopamine].
In 12 patients with low output after open-heart surgery the therapeutic effect of vasodilatation with sodium nitroprusside (SNP) and dopamine was studied. All patients underwent aortocoronary bypass operations. After cardiopulmonary bypass, the cardiac index (CI) was 2.2 liters/min.m2. The pulmonary wedge pressure (PCWP) was about 20 mm Hg. Application of SNP lowered mean arterial pressure to 82 and PCWP to 13 mm Hg. Then PCWP was elevated to the control level by tranfusion of blood. This therapy increased CI by about 30% without positive inotropic intervention. Additional application of 5 micrograms dopamine/kg.min improved the CI to 3.8 liters/min.m2.
D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D001026:Coronary Artery Bypass; D004298:Dopamine / Q000627:therapeutic use*; D005112:Extracorporeal Circulation; D005292:Ferricyanides / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009599:Nitroprusside / Q000627:therapeutic use*; D014664:Vasodilation / Q000187:drug effects
D005292:Ferricyanides; D009599:Nitroprusside; D004298:Dopamine
Therapie des Low-output-Syndroms bei Patienten nach kardiopulmonalem Bypass mit Natriumnitroprussid und Dopamin.