Luteinizing hormone-releasing hormone and serum growth hormone in insulin-dependent diabetes.
Growth hormone (GH) responses were studied in 26 insulin-dependent diabetics after the intravenous administration of 100 microgram of synthetic luteinizing hormone-releasing hormone (LH-RH). Although the mean basal GH concentration was significantly higher than that of 20 matched non-diabetic controls, no significant increment occurred after the LH-RH injection. (The controls also showed no rise in GH.) It seems that the GH hypersecretion of insulin-requiring diabetics does not, as is frequently noted in acromegaly, respond to the injection of LH-RH.
D000293:Adolescent; D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D013268:Stimulation, Chemical
D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone