title: Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis in Saccharomyces.
abstract: A procedure for detection of mutants exhibiting either enhanced or reduced spontaneous mutation during mitosis and/or meiosis has been developed to probe the joint genic control of spontaneous mutation and recombination in yeast. A semidominant mutator, rem1-1, recovered by this technique, exhibits enhanced spontaneous mutation,intragenic recombination, and intergenic recombination during mitosis. Diploids homozygous for rem1-1 exhibit normal levels of meiotic intragenic and intergenic recombination and diminished ascospore viability.
mesh_terms: D000818:Animals; D004171:Diploidy; D004285:Dogs; D005799:Genes, Dominant; D005821:Genetic Techniques; D005838:Genotype; D008540:Meiosis; D008938:Mitosis; D009154:Mutation; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae; D014364:Tryptophan / Q000378:metabolism
chemical_list: D014364:Tryptophan