Contribution of T cell-mediated immunity to the resistance to staphylococcal infection.
Abscess formation in nude mice after subcutaneous inoculation of Staphylococcus aureus (S. aureus) was more extensive and prolonged as compared with that in phenotypically normal littermates. Abscess formation in nude mice was augmented markedly by whole-body irradiation. Not only T cell-mediated immunity but also radiosensitive, nonimmune phagocytosis appear to contribute to the resistance against staphylococcal infection.
D000038:Abscess / Q000276:immunology; D000818:Animals; D005260:Female; D007111:Immunity, Cellular / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013203:Staphylococcal Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000528:radiation effects