Antibody-dependent cellular cytotoxicity in asthmatics.
Using a 51Cr-labeled, antibody-coated chicken red blood cell assay system, mononuclear cell and granulocyte preparations from infectious asthmatics, noinfectious asthmatics, and normal controls were tested for antibody-dependent cellular cytotoxicity (ADCC) capacity. The corrected cytotoxic indices of mononuclear cell preparations from infectious asthmatics were reduced (34 +/- 10 SD) as compared to noninfectious asthmatiics (47 +/- 7 SD) or normal controls (47 +/- 6 SD). Granulocyte preparations from infectious asthmatics and normal controls had a severity of the disease or in vivo drug treatment.
D000328:Adult; D000918:Antibody Specificity; D001249:Asthma / Q000150:complications / Q000276:immunology*; D003141:Communicable Diseases / Q000150:complications; D003601:Cytotoxicity Tests, Immunologic; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D013997:Time Factors