Inhibition of the E-rosette formation of T-lymphocytes by aggregated human IgG and restoration by levamisole.
Aggregated human IgG significantly inhibited the E-rosette formation of T lymphocytes of healthy subjects and cancer patients. The aggregated IgG induced inhibition of rosette forming cells depended on the time of preincubation at 37 degrees. Levamisole, an anti-anergic chemotherapeutic agent, could partly but significantly prevent the aggregated IgG induced inhibition of the E-rosette formation.
D004306:Dose-Response Relationship, Immunologic; D006358:Hot Temperature; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007978:Levamisole / Q000494:pharmacology*; D046911:Macromolecular Substances; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D046911:Macromolecular Substances; D007978:Levamisole