title: The effect of serotonin on pepsin inhibition by duodenal fat.
abstract: The purpose of these studies was to evaluate the possible role of serotonin on pepsin secretion. The results of our data suggest that serotonin is a stimulator of pepsin secretion since (a) pretreatment with reserpine (which depletes serotonin stores) abolished the stimulatory effect of histamine on pepsin secretion; (b) pretreatment with UML-491 (a serotonin blocking agent at the effector level) augmented the pepsin inhibition induced by the intraduodenal infusion of fat, and (c) 5-hydroxytryptophan (a serotonin precursor) caused a significant stimulation of pepsin secretion. The mode of action of serotonin is probably by a direct hormonal action on the gastric chief cells.
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000187:drug effects* / Q000502:physiology; D005223:Fats / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D013270:Stomach / Q000502:physiology*
chemical_list: D005223:Fats; D012701:Serotonin; D006632:Histamine; D012110:Reserpine; D010434:Pepsin A