[T- and B-lymphocyte count in the spleen and lymph nodes of guinea pigs administered oxytetracycline intramuscularly].
The E and EAC rosette formation tests, carried out in order to determine the count of T and B lymphocytes in the spleen and lymph nodes of guinea pigs after several intramuscular of oxytetracycline, showed a decrease in the ability of B lymphocytes in the reaction of EAC rosette formation with the simultaneous rise of the level of "zero" cells without surface receptors characteristic of T and B lymphocytes. The data obtained in this study indicated the possibility for tetracyclines to effect the differntiation and ripening of the medullary precursors of B lymphocytes.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D006168:Guinea Pigs; D007165:Immunosuppression Therapy; D007273:Injections, Intramuscular; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000187:drug effects*; D010118:Oxytetracycline / Q000008:administration & dosage* / Q000276:immunology; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*; D013997:Time Factors
D010118:Oxytetracycline
Kolichestvo T- i B-limfotsitov v selezenke i limfaticheskikh uzlakh morskikh svinok v uslovii vnutrimyshechnogo vvedeniia oksitetratsiklina.