title: Biology of psychoses: past research and new frontiers.
abstract: This paper reviews major research developments in the biology of mental illness. Theories concerning schizophrenia and affective disease are shown to be based on the mode of action of drugs discovered in the 1950s and used in the treatment of these disorders. Discovery of the endorphins and the development of a new receptor site neurobiology are shown to have a potential major impact on the future of psychiatric research.
mesh_terms: D000928:Antidepressive Agents / Q000266:history / Q000627:therapeutic use; D002621:Chemistry; D002707:Chlordiazepoxide / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000266:history; D004723:Endorphins; D049673:History, 20th Century; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced; D010455:Peptides / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy / Q000266:history; D011955:Receptors, Drug; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D013375:Substance Withdrawal Syndrome; D014481:United States; D008083:beta-Lipotropin / Q000009:adverse effects
chemical_list: D000928:Antidepressive Agents; D004723:Endorphins; D010455:Peptides; D011955:Receptors, Drug; D002707:Chlordiazepoxide; D008083:beta-Lipotropin