Imbalances of T cell subpopulations in patients with atopic diseases and effect of specific immunotherapy.
Reduced numbers of T cells with Fc receptors for IgG (TG cells) are present in blood samples of patients with respiratory allergic disease, mainly those with severe symptoms. TG cells have been previously shown to be suppressor in the pokeweed mitogen- (PWM) dependent B cell differentiation. T cells with Fc receptor for IgM (TM cells), which help immunoglobulin production, are in a normal range. After specific hyposensitization, resulting in a sharp improvement of clinical symptoms, TG cell subset reached normal values.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged; D012130:Respiratory Hypersensitivity / Q000276:immunology; D012220:Rhinitis / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification*
D003692:Delayed-Action Preparations