[Action of pharmacological effectors on hematocrit and lactate dehydrogenase activity changes in experimental ischemic shock].
The experimental ischemic shock induced by removing tourniquets in rats, were studied. Durin 164 hours, the variations of the values of hematocrit and of muscle and plasma dehydrogenase lactate activity were followed up; the modifications of these variations after pharmacological high doses of dexamethasone phosphate, hydrocortisone hemisuccinate and aprotinine administered intravenously, were evaluated. The best action was noted after dexamethasone phosphate treatment.
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004912:Erythrocytes; D006400:Hematocrit; D006854:Hydrocortisone / Q000627:therapeutic use*; D007275:Injections, Intravenous; D007511:Ischemia; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D009132:Muscles / Q000201:enzymology; D051381:Rats; D012769:Shock / Q000188:drug therapy*; D014111:Tourniquets
D003907:Dexamethasone; D007611:Aprotinin; D007770:L-Lactate Dehydrogenase; D006854:Hydrocortisone
Action d'effecteurs pharmacologiques sur les variations de l'hématocrite et de l'activité lactate déshydrogénasique au cours du choc ischémique expérimental