Differences in antischistosomal and mutagenic properties between an isothiocyano- and an isocyanonitrodiphenylamine.
While 4-isothiocyano-4'-nitrodiphenylamine has high schistosomicidal activity in vivo and is devoid of mutagenic properties in vitro, the reverse is true for the isocyano analogue of this compound; i.e., replacement of the sulfur by oxygen results in a compound that has no demonstrable antischistosomal effects and exhibits significant mutagenic activity.
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects; D012552:Schistosomiasis / Q000188:drug therapy; D012556:Schistosomicides / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D009153:Mutagens; D012556:Schistosomicides; D004159:Diphenylamine