[Associated myasthenia and disseminated lupus erythematosus. A report on two cases and complete review of the published literature (author's transl)].
Two patients aged 47 and 48 years respectively were found to have associated immunity disorders: myasthenia and DLE in the first case, and erythroblastic anemia, myasthenia, a lupus syndrome, and a thymoma in the second case. The association of myasthenia and DLE has been reported 39 times in the published literature (20 times only if stricter biological criteria are applied). The association does not increase the severity of the patient's condition and a thymoma is not present more frequently. Studies on the major histocompatibility complex and lymphocyte levels are still insufficient in this context: the haplotype was HLA A1 B8 in three cases out of seven. The physiopathological data available cannot confirm the possibility of a common pathogenesis in which the thymus and lymphocytes could play a determining role.
D000906:Antibodies / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000150:complications* / Q000276:immunology; D013789:Thalassemia / Q000150:complications; D013934:Thymectomy; D013945:Thymoma / Q000150:complications
D000906:Antibodies; D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D004247:DNA
Les associations myasthénie-lupus érythémateux disséminé. A propos de deux observations avec revue complète de la littérature.