Mechanisms of the flare reaction in human skin.
The diffuse area of arteriolar vasodilation surrounding a region of recently injured human skin (axon reflex flare) is dependent upon the integrity of nerve fibers with cell bodies located in dorsal root ganglia. Evidence is presented to indicate that a vasodilator peptide similar to a kinin, neurotensin, or substance P, is implicated in the chain of biochemical events responsible for the transient shift in vascular tonus observable as the flare reaction.
D000344:Afferent Pathways / Q000503:physiopathology; D001917:Brachial Plexus / Q000503:physiopathology; D001920:Bradykinin / Q000494:pharmacology; D002056:Burns / Q000503:physiopathology; D003872:Dermatitis / Q000503:physiopathology*; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000503:physiopathology; D006801:Humans; D007704:Kininogens / Q000494:pharmacology; D007705:Kinins / Q000096:biosynthesis; D008833:Microcirculation / Q000187:drug effects; D008970:Molecular Weight; D009411:Nerve Endings / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D010477:Perfusion; D010543:Peroneal Nerve / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000503:physiopathology; D013562:Sympathectomy; D014666:Vasomotor System / Q000187:drug effects
D007704:Kininogens; D007705:Kinins; D001920:Bradykinin