Successful bone marrow transplant for Fanconi's anaemia.
A 15-year-old boy with Fanconi's anaemia, who required four units of blood each month, received a bone marrow graft from his 9-year-old brother, who has HLA identical and compatible on mixed lymphocyte reaction. Considerable immunosuppression was used and bacterial infection was prevented by vigorous decontamination in a Vickers-Trexler isolator. After the graft the patient's blood counts remained satisfactory for nine months, but it took six months before qualitative immune function was normal.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005199:Fanconi Anemia / Q000628:therapy*; D006410:Hematopoiesis; D006648:Histocompatibility; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D013997:Time Factors; D014184:Transplantation, Homologous