title: Ultrastructure and function of interdigitating cells in the guinea pig thymus.
abstract: Electron micrsocopic investigation of the thymus of normal guinea pigs of both sexes, approximately 3 months of age, have shown that the organ contains at least two types of non-lymphoid cells: epithelial reticulum cells and so-called interdigitating cells. The latter have been observed in the inner part of the cortex and are morphologically characterized by an irregularly shaped or kidney-shaped nucleus, many tubulovesicular cytoplasmic structures accumulated mostly within the cytocentre as well as by finger-like protrusions of the cytoplasm. These interdigitating cells are in close contant with neighbouring lymphocytes with partly destroyed pycnotic nucleus.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006168:Guinea Pigs; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000648:ultrastructure; D013950:Thymus Gland / Q000648:ultrastructure*