19-Nortestosterone in mouse kidney.
19-Nortestosterone was identified as a product of testosterone conversion in vitro in male mouse kidney. After incubation of [14C]testosterone with kidney slices of castrated male mice, 64% of the radioactivity was recovered as testosterone, about 6% as epitestosterone and 2.5% was identified as 19-nortestosterone. The renotrophic effect of 19-nortestosterone was at least as high as that of testosterone. Possible role of 19-nortestosterone in mouse kidney is discussed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D004845:Epitestosterone / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D009277:Nandrolone / Q000378:metabolism* / Q000494:pharmacology; D012669:Seminal Vesicles / Q000187:drug effects; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology
D013739:Testosterone; D004845:Epitestosterone; D009277:Nandrolone