Metabolic regulation as a control for lipid disorders. I. Influence of (--)-hydroxycitrate on experimentally induced obesity in the rodent.
The feasibility of treating obesity by metabolic regulation has been explored in this study by examining the effect of (--)-hydroxycitrate on three types of experimentally induced obesity in the rodent.(--)-Hydroxycitrate was utilized because it depressed fatty acid and cholesterol synthesis in vivo through its activity as a potent competitive inhibitor of APT citrate lyase. In all models, the mature rat, the goldthioglucose-induced obese mouse, and the ventromedial hypothalmic lesioned obese rat, food intake and body weight gain were reduced signficantly by the chronic oral administration of a nontoxic dose of (--)-hydroxcitrate. Body composition analyses of mature rats treated with (--)-hydroxycitrate demonstrated a significant depression of body lipid levels and an unaltered body protein content. However, a citrate administration produced no significant effects on weight gain, food intake, or body lipid or protein levels when compared to controls.
D000818:Animals; D001067:Appetite Depressants / Q000627:therapeutic use; D006051:Aurothioglucose; D001823:Body Composition; D001835:Body Weight / Q000187:drug effects; D002951:Citrates / Q000627:therapeutic use*; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D007033:Hypothalamus, Middle / Q000502:physiology / Q000601:surgery; D050356:Lipid Metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009765:Obesity / Q000139:chemically induced / Q000188:drug therapy*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
D001067:Appetite Depressants; D002951:Citrates; D011506:Proteins; D006051:Aurothioglucose