title: Lymphocyte-associated immune responses to canine distemper and measles viruses in distemper-infected gnotobiotic dogs.
abstract: Cellular immune responses of peripheral blood lymphocytes to canine distemper virus and measles virus were determined in vaccinated or infected gnotobiotic dogs, using the technique of syncytia inhibition. Cross-reactivity between viruses was detected in both groups of dogs. Peak responses in vaccinated dogs occurred 11 days after vaccination and declined to base-line levels by 3 weeks, whereas responses in infected dogs were present 30 days after inoculation. Fractionation experiments with peripheral blood lymphocytes indicated that synctia inhibition is probably mediated by T lymphocytes.
mesh_terms: D000818:Animals; D003429:Cross Reactions; D004216:Distemper / Q000276:immunology*; D004217:Distemper Virus, Canine / Q000254:growth & development / Q000276:immunology*; D004285:Dogs / Q000276:immunology*; D005856:Germ-Free Life; D008214:Lymphocytes / Q000276:immunology*; D008459:Measles virus / Q000254:growth & development / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000662:veterinary