Clonal origin of a T cell lymphoproliferative malignancy.
A woman with a T cell lymphoproliferative malignacy and heterozhgosity at the X chromosome-linked locus for glucose-6-phosphate dehydrogenase (G-6PD) isoenzymes was studied to find the clonal origin of her circulating neoplastic T cells. The red blood cells, polymorphonuclear cells, whole mononuclear cells, and T cell-depleted mononuclear cells contained both A and B isoenzymes of G-6-PD. In contrast, the tumor cells, separated by using their capacity to form rosettes with sheep red blood cells, contained only the B isoenzyme of G-6-PD. This observation strongly suggests the monoclonality of this T cell malignancy.
D000328:Adult; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D008206:Lymphatic Diseases / Q000097:blood*; D008214:Lymphocytes / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D005954:Glucosephosphate Dehydrogenase