title: Genetic characterization of an Escherichia coli mutant altered in the structure of murein lipoprotein.
abstract: Mutants defective in the structure, biosynthesis, and assembly of murein lipoprotein have been isolated. One of these mutants has been shown to synthesize a structurally altered lipoprotein. The biochemical features of the mutant lipoprotein (lipid deficiency, dimer formation, and a reduced, bound form of lipoprotein) could be attributed to a single mutation (or closely linked mutations) located at 36.4 min of the Escherichia coli map. We propose that this mutant is altered in the structural gene for murein lipoprotein (mlpA). Biochemical studies carried out with a heterogenote, mlpA/F'mlpA+, revealed the biochemical codominance of the wild-type and mutant genes.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D002874:Chromosome Mapping; D004926:Escherichia coli / Q000378:metabolism*; D005796:Genes; D008074:Lipoproteins / Q000096:biosynthesis*; D009154:Mutation; D010457:Peptidoglycan / Q000096:biosynthesis*; D011487:Protein Conformation
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins; D010457:Peptidoglycan