Ergotism with therapeutic doses of ergotamine tartrate.
Two cases of acute ergotism are described in patients taking therapeutic oral doses of ergotamine tartrate and concomitant triacetyloleandomycin. Both showed satisfactory response to infusion of sodium nitroprusside with normal perfusion being obtained in the affected limbs. The treatment of ergotism with sodium nitroprusside is reviewed and the apparent interaction of ergotamine and triacetyloleandomycin is discussed.
D000328:Adult; D004347:Drug Interactions; D004879:Ergotamines / Q000009:adverse effects* / Q000627:therapeutic use; D004881:Ergotism / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D009599:Nitroprusside / Q000627:therapeutic use; D014217:Troleandomycin / Q000009:adverse effects*
D004879:Ergotamines; D009599:Nitroprusside; D014217:Troleandomycin