title: [Carbenicillin in the treatment of acute and chronic bacterial pneumonias].
abstract: A total of 50 patients suffering from acute and chronic bacterial pneumonia were treated with sodium carbenicillin. The bacteriological analysis of the sputum showed that Str. pneumoniae predominated in the monoculture or its association with other bacteria. Connection of the results of the bacteriological analysis with the clinical efficiency of the therapy was studied. When carbenicillin was administered intramuscularly in a dose of 1 gm, its therepeutic effect was maintained in the blood for 4 to 6 hours. A satisfactory clinical effect was registered in 41 out of 50 patients treated with carbenicillin in a daily dose 4--6 gm for 8--10 days. No toxic effect of carbenicillin on the parenchimatous organs and peripheral blood was noted.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002228:Carbenicillin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy*; D013183:Sputum / Q000382:microbiology; D013997:Time Factors
chemical_list: D002228:Carbenicillin
vernacular_title: Karbenitsillin v lechenii ostrykh i khronicheskikh bakterial'nykh pnevmoniĭ