Plasma tryptophan and musculoskeletal pain in non-articular rheumatism ("fibrositis syndrome").
Plasma-free tryptophan is inversely related to the severity of subjective pain in 8 patients who fulfilled criteria for a variety of non-articular rheumatism, the "fibrositis syndrome". The observation is consistent with animal and human studies suggesting a relationship between reduced brain serotonin metabolism and pain reactivity.
D000328:Adult; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology*; D012216:Rheumatic Diseases; D012701:Serotonin / Q000502:physiology; D013577:Syndrome; D014364:Tryptophan / Q000097:blood*
D012701:Serotonin; D014364:Tryptophan