[Transfer in vivo of cytotoxic immune lymphocytes obtained in vitro in primary culture against a murine lymphoma antigenically altered by DTIC].
Specific cytotoxic T cells were obtained by coculturing "in vitro" normal spleen cells with inactivated histocompatible DTIC-altered lymphoma cells. The "in vivo" antitumor activity of such sensitized lymphocytes was evaluated by injecting a mixture of lymphocytes + tumor into the brains of lethally irradiated syngenic mice. The results indicated that such lymphocytes demonstrate antitumor activity against the same tumor but not against unrelated tumors.
D000818:Animals; D003606:Dacarbazine / Q000494:pharmacology / Q000627:therapeutic use*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D003606:Dacarbazine
Transfer "in vivo" di linfociti immuni citotossici ottenuti "in vitro" in coltura primaria contro un linfoma murino antigenicamente alterato dal DTIC.