Sensitization of guinea pigs to levamisole.
Levamisole, an anti-helminthic drug used also as an immunostimulating agent, has been found to be a potent skin sensitizer in experimental animal models. Sensitization is associated with marked T-lymphocyte proliferation in the draining lymph node. It is suggested that immunostimulation through increase in the T-lymphocyte population could be a function of the strong sensitization induced by this compound.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D007978:Levamisole / Q000276:immunology* / Q000494:pharmacology; D008198:Lymph Nodes / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D007978:Levamisole