Precursors of B-lymphocytes with surface IgM and their possible migration from bone marrow to peripheral lymphatic tissues.
The lymphocytes with surface immunoglobulins (sIg) represent precursors of B-lymphocytes and were studied in ontogeny of pigs by autoradiography using iodinated monospecific anti-mu, anti-gamma or anti-alpha antibodies. The earliest detection of sIgM+ small lymphocytes was at 44 days of gestation in liver, followed at 51 days in spleen and at 60 days in bone marrow, the thymocytes being sIg-negative. The first circulating small lymphocytes were detected at 38--40 days and are most probably thymus-derived.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D005333:Fetus / Q000276:immunology*; D007074:Immunoglobulin G; D008099:Liver / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D013154:Spleen / Q000276:immunology; D013552:Swine; D015017:Yolk Sac / Q000276:immunology
D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell