title: Impaired amylase release from the parotid gland of rats treated with reserpine.
abstract: Using an automated system for the analysis of amylase, the release of this enzyme was compared in superfused parotid gland segments from control and reserpine treated rats. Stimulant-evoked amylase release was delayed and of smaller magnitude in the glands of the treated animals and a reduction of the transmembrane K+ gradient caused a smaller and short lasting reduction in Ach-evoked release of amylase in the glands from these animals.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D007700:Kinetics; D010306:Parotid Gland / Q000187:drug effects / Q000201:enzymology*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D000516:alpha-Amylases / Q000378:metabolism
chemical_list: D010656:Phenylephrine; D012110:Reserpine; D000681:Amylases; D000516:alpha-Amylases; D007545:Isoproterenol; D000109:Acetylcholine; D004837:Epinephrine