Renal transplantation and immunological abnormalities in thrombotic microangiopathy of adults: report of 5 cases.
Renal transplantation was performed in five adult patients with thrombotic microangiopathy, three of whom had had a bilateral nephrectomy prior to transplantation. The graft remained functional in three patients 72, 18, and 12 months after transplantation. One patient developed a thrombosis of the renal artery and one patient died from infection. There was no clinical or histological evidence of recurrence of thrombotic microangiopathy in the five patients after transplantation. Immunological investigations were performed in four of five patients before transplantation: C3 and C1q levels were low in two patients; serum C3-splitting activity and circulating immune complexes were present in all four patients and remained unchanged on haemodialysis and/or after bilateral nephrectomy. Complement abnormalities and immune complexes were not detected in the three patients with successful renal transplantation.
D058186:Acute Kidney Injury / Q000209:etiology / Q000276:immunology / Q000601:surgery*; D000328:Adult; D000936:Antigen-Antibody Complex; D003176:Complement C3; D005260:Female; D006801:Humans; D007109:Immunity; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000276:immunology / Q000601:surgery*; D014184:Transplantation, Homologous
D000936:Antigen-Antibody Complex; D003176:Complement C3