Blastogenic transformation by lipopolysaccharide of blood leukocytes from immunized but not normal cattle.
Escherichia coli lipopolysaccharide produced blastogenic transformation in whole-blood leukocytes from heifers that had been infected and immunized with Campylobacter fetus, but not in cells from control animals. This suggests that lipopolysaccharide dose not function as a B-cell mitogen in cattle and that its stimulation of cells from immunized animals occurred through another mechanism.
D000818:Animals; D000942:Antigens, Bacterial; D002169:Campylobacter Infections / Q000276:immunology*; D002168:Campylobacter fetus / Q000276:immunology; D002417:Cattle; D004926:Escherichia coli; D007114:Immunization; D037102:Lectins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008213:Lymphocyte Activation; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*
D000942:Antigens, Bacterial; D037102:Lectins; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial