Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro.
Peritoneal macrophages from rats with adjuvant arthritis enhance the incorporation of 3H-thymidine in 2 tumour cell lines in vitro. Maximal enhancement is found during the development of the secondary lesions, and it is suggested that the immunologic commitment of the macrophages could interfere with their regulation of tumour cell proliferation in vivo.
D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000503:physiopathology*; D002455:Cell Division; D002460:Cell Line; D004261:DNA Replication; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D012517:Sarcoma, Yoshida / Q000503:physiopathology*; D013936:Thymidine / Q000378:metabolism
D013936:Thymidine