title: Intraspinal arachnoiditis and hydrocephalus after lumbar myelography using methylglucamine iocarmate.
abstract: A 35 year old woman developed a severe meningeal reaction after lumbar myelography using the water-soluble contrast medium methylglucamine iocarmate. Three months after myelography the findings were a transverse spinal cord syndrome corresponding to the middle thoracic segments resulting from well developed leptomeningeal adhesions. This was combined with a noncommunicating hydrocephalus, probably the result of leptomeningeal fibrosis in the posterior fossa. After treatment with a ventriculoatrial shunt the patient is almost free of symptoms. A possible pathogenetic relationship between the contrast medium, the chronic leptomeningeal changes, and the symptoms of our patient is discussed on the basis of the literature.
mesh_terms: D000328:Adult; D001100:Arachnoiditis / Q000209:etiology* / Q000601:surgery; D002493:Central Nervous System Diseases / Q000209:etiology; D014695:Cerebral Ventriculography; D002557:Cerebrospinal Fluid Shunts; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000601:surgery; D007796:Laminectomy; D008536:Meglumine / Q000009:adverse effects*; D009192:Myelography / Q000009:adverse effects*; D013012:Sorbitol / Q000031:analogs & derivatives*; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000601:surgery
chemical_list: D003287:Contrast Media; D013012:Sorbitol; D008536:Meglumine