Defective neutrophil chemotaxis and bactericidal power in a child with hyperimmunoglobulinemia E.
An 11-year-old boy with a life-long history of atopic-like dermatitis and recurrent staphylococcal abscesses was found to have defective neutrophil chemotaxis, impaired-T-lymphocyte functions, hyperimmunoglobulinemia E, and delayed neutrophil bactericidal power. This latter defect has never been found in such patients. The patient's mother revealed a panhypogammaglobulinemia, while his sister and maternal grandmother who had repeated infections were immunologically normal.
D002634:Chemotaxis, Leukocyte; D002648:Child; D003876:Dermatitis, Atopic / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood*; D007073:Immunoglobulin E; D008297:Male; D009504:Neutrophils / Q000473:pathology*; D013601:T-Lymphocytes
D007073:Immunoglobulin E