Antibodies to Candida albicans in IgA-deficient humans.
Titers of serum antibody to Candida albicans were studied in 111 IgA-deficient subjects by the passive hemagglutination method. Circulating antibodies to C. albicans (mean titer, 1:7) were found in only 7.3% of the 111 subjects, as compared with 80% of 137 controls (mean titer, 1:16). However, two IgA-deficient patients with systemic candidiasis were positive for these antibodies (mean titer, 1:64). Indirect immunofluorescence tests indicated that the antibody response in IgA-deficient subjects to superficial or deep-seated infection with C. albicans consists mainly of immunoglobulins of the IgG rather than of the IgM class.
D000908:Antibodies, Fungal / Q000096:biosynthesis*; D002176:Candida albicans / Q000276:immunology*; D004406:Dysgammaglobulinemia / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006386:Hemagglutination Tests; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis
D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M