title: Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.
abstract: Nonsteroidal anti-inflammatory drugs inhibit the biosynthesis of kinins and prostaglandins and stabilize leukocyte lysosomal membranes. Nonsteroidal anti-inflammatory drugs also weakly block the biosynthesis of histamine and serotonin, and pharmacologically antagonize kinins, prostaglandins and slow-reacting substance of anaphylaxis. Nonsteroidal anti-inflammatory drugs effectively control both cardiovascular and respiratory manifestations of hypersensitivity in cattle and horses. This, coupled with the contrasting lack of effectiveness of "antiamine" drugs, suggests that bio-amines such as histamine and serotonin (5-hydroxytryptamine) may be less important than kinins, postaglandins and slow-reacting substance in the mediation of the hypersensitivity/inflammatory reaction, at least in cardiopulmonary systems of these species. Nonsteroidal anti-inflammatory drugs justify more prominence in the clinical control of acute respiratory disease in domestic herbivores.
mesh_terms: D000707:Anaphylaxis / Q000662:veterinary; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001168:Arthritis / Q000662:veterinary; D001196:Ascariasis / Q000662:veterinary; D001241:Aspirin / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004049:Diethylcarbamazine / Q000627:therapeutic use; D006168:Guinea Pigs; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D006967:Hypersensitivity / Q000188:drug therapy / Q000662:veterinary*; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation; D007705:Kinins / Q000037:antagonists & inhibitors; D007962:Leukocytes / Q000201:enzymology; D008469:Meclofenamic Acid / Q000627:therapeutic use; D010587:Phagocytosis; D010653:Phenylbutazone / Q000627:therapeutic use; D011016:Pneumonia, Atypical Interstitial, of Cattle / Q000188:drug therapy; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D007705:Kinins; D011448:Prostaglandin Antagonists; D013189:SRS-A; D008469:Meclofenamic Acid; D010653:Phenylbutazone; D001241:Aspirin; D004049:Diethylcarbamazine; D007213:Indomethacin