Synthesis and biological activity of potential antimetabolites.
Several known alpha-amino acid analogues and a new compound, N-chloroacetylphosphoramidate, a carbamyl phosphate analogue, were screened as antitumor agents. All gave 50% growth inhibition of cultures of human epidemeroid carcinoma of the nasopharynx at dosage levels of 2-8 mug/ml while showing no activity against L1210 lymphoid leukemia in vivo in BDFi mice.
D000081:Acetamides / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000596:Amino Acids / Q000138:chemical synthesis*; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use; D001221:Aspartate Carbamoyltransferase / Q000037:antagonists & inhibitors; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002478:Cells, Cultured; D004926:Escherichia coli / Q000201:enzymology; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy; D008722:Methods; D051379:Mice; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use
D000081:Acetamides; D000596:Amino Acids; D000964:Antimetabolites, Antineoplastic; D009943:Organophosphorus Compounds; C013875:N-chloroacetylphosphoramidate; D001221:Aspartate Carbamoyltransferase