title: Hemoglobin ontogenesis: test of the gene excision hypothesis.
abstract: The gene excision hypothesis of hemoglobin ontogenesis was tested in persons with HbSC disease, with the use of monospecific fluorescent antibodies for the identification of hemoglobins S, C, and F in individual erythrocytes. The results are incompatible with the prediction that only one gamma- or beta-globin gene may be active in any single chromosome and provide further evidence for incomplete repression of gamma-globin genes lying cis to active beta-globin genes.
mesh_terms: D005319:Fetal Hemoglobin / Q000096:biosynthesis*; D005455:Fluorescent Antibody Technique; D005796:Genes; D006444:Hemoglobin C / Q000096:biosynthesis*; D006451:Hemoglobin, Sickle / Q000096:biosynthesis*; D006579:Heterozygote; D006801:Humans
chemical_list: D006451:Hemoglobin, Sickle; D006444:Hemoglobin C; D005319:Fetal Hemoglobin