Erythroid leukemia induced by Friend lymphatic leukemia virus in T-cell-depleted mice.
BALB/c mice depleted of T-cells by thymectomy at 3 to 5 days of age and by treatment with antithymocyte serum were inoculated with the lymphatic leukemia virus derived from Friend virus. After a long latent period, these animals developed erythroid leukemia. In contrast, intact control mice inoculated with Friend virus-associated lymphatic leukemia virus developed typical thymic (T-cell) lymphomas. Cell-free virus prepared from leukemic T-cell-depleted animals induced lymphoid, myeloid, and erythroid leukemias in intact mice. The erythroid leukemia-inducing virus differed from the spleen focus-forming component of Friend virus in its long latent period (88 to 225 days) and in its inability to induce spleen foci. End-point dilution experiments suggested that a hitherto undescribed component of the Friend virus complex might be responsible for these late-appearing erythroid leukemias.
D000818:Animals; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000209:etiology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000209:etiology; D007945:Leukemia, Lymphoid / Q000209:etiology; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology; D014412:Tumor Virus Infections / Q000209:etiology