The study of T-, B-, O- lymphocytes in acute lymphoblastic leukemia.
The T-, B-, and O-lymphocyte count changes were studied during the long-term intensive therapy of 43 ALL children. The control group consisted of 17 healthy children. The T-lymphocytes were identified by spontaneous formation of rosettes with sheep erythrocytes, the B-lymphocytes by EAC-rosette test. Patients were treated according to different program of multiple drug therapy and prophylactic cranial irradiation. During the study the applied therapeutic protocol produced the marked reduction of T- and B- lymphocytes. The decrease of B- lymphocytes was especially pronounced. The preliminary analysis suggests correlation between the reduction of T- and B- lymphocytes and prognosis.
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D007111:Immunity, Cellular; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000276:immunology* / Q000532:radiotherapy; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors