Antidepressant evaluation and the pharmacological actions of FG4963 in depressive patients.
FG4963 a phenylpiperidine derivative and potent 5-HT reuptake inhibitor at neuronal sites was investigated in a group of 10 depressive patients, and its effect was compared with that of amitryptyline in a group of 10 depressive patients treated with amitriptyline. FG4963 was found to be significantly inferior as an antidepressant compared to amitryptyline over a 6-week period. FG4963 did not appear to be anticholinergic as judged by its lack of effect on salivary flow. Its effect (in the dosage used) on the tyramine dose--pressor response and NA dose--pressor response tests were less than those of amitryptyline.
D000639:Amitriptyline / Q000627:therapeutic use; D000840:Anisoles / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000928:Antidepressive Agents; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics; D010880:Piperidines / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D013566:Sympathomimetics; D014439:Tyramine / Q000494:pharmacology
D000840:Anisoles; D000928:Antidepressive Agents; D010276:Parasympatholytics; D010880:Piperidines; D013566:Sympathomimetics; D000639:Amitriptyline; D014439:Tyramine