title: Methotrexate: clinical pharmacology, current status and therapeutic guidelines.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005493:Folic Acid Antagonists; D006207:Half-Life; D006801:Humans; D002955:Leucovorin / Q000494:pharmacology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D002955:Leucovorin; D008727:Methotrexate