Norleucine accumulation by a norleucine-resistant mutant of Serratia marcescens.
A norleucine-resistant mutant was derived from an isoleucine-valine auxotroph of a leucine accumulator of Serratia marcescens. The norleucine-resistant mutant could accumulate norleucine from norvaline in the medium without the addition of methionine, which antagonized norleucine. This mutant constitutively formed homoserine-O-transsuccinylase.
D000217:Acyltransferases / Q000096:biosynthesis; D000614:Aminocaproates / Q000096:biosynthesis*; D004352:Drug Resistance, Microbial; D005246:Feedback; D006714:Homoserine; D008715:Methionine / Q000378:metabolism; D009154:Mutation; D009646:Norleucine / Q000096:biosynthesis* / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D013386:Succinates; D014633:Valine / Q000031:analogs & derivatives / Q000378:metabolism
D000614:Aminocaproates; D013386:Succinates; D006714:Homoserine; D009646:Norleucine; D008715:Methionine; D000217:Acyltransferases; D014633:Valine