[Study of the role of the plasmid-determined sucrose index in Salmonella newport in the development of experimental infectious process].
The authors studied the role played by Sac-plasmide of atypical S. newport strains inducing a more severe course of the disease in the development of the infectious process in man. In experiments with genetically-bound strains of salmonellae and E. coli K12, differing by the presence of Sac-plasmide, it was shown that the acquisition or the loss of the latter failed to effect significantly the capacity of the microbes to cause death of chick embryos infected on the membrane, to reproduce in the pulmonary tissue of mice infected intranasally, and affect the cells of the L1 strain. Genetic confirmation of the absence of any connection between the sucrose sign determined by plasmide and the capacity of the strains to cause dilatation of the ligated rabbit intestinal loop was presented. The data obtained indicated that high virulence of the S. newport strains under study was not associated with the presence of Sacplasmide in them.
D000818:Animals; D002642:Chick Embryo; D002876:Chromosomes, Bacterial; D004926:Escherichia coli / Q000472:pathogenicity; D005111:Extrachromosomal Inheritance; D051379:Mice; D010957:Plasmids; D012475:Salmonella / Q000378:metabolism / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000382:microbiology*; D013395:Sucrose / Q000378:metabolism*; D014774:Virulence
D013395:Sucrose
Izuchenie v S. newport roli determiniruemogo plazmidom sakharoznogo priznaka v razvitii eksperimental'nogo infektsionnogo protsessa.