Quantitative structure-activity relationships of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines.
A quantitative structure-activity relationship (QSAR) for the inhibition of dihydrofolate reductase from S. faecium by quinazolines has been formulated. This is compared with a QSAR for inhibition of E. coli dihydrofolate reductase by 2,4-diamino-5-benzylpyrimidines. The QSAR for inhibition of bacterial enzyme is compared with QSAR for mammalian enzyme inhibition. A QSAR has been formulated for the antimalarial action of quinazolines against P. berghei in mice. The antimalarial QSAR is consistent with that of the in vitro bacterial study.
D000818:Animals; D000962:Antimalarials / Q000032:analysis / Q000494:pharmacology; D004926:Escherichia coli / Q000201:enzymology; D005493:Folic Acid Antagonists; D008433:Mathematics; D051379:Mice; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D013291:Streptococcus / Q000201:enzymology; D013329:Structure-Activity Relationship
D000962:Antimalarials; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D011799:Quinazolines