L-cysteine hydrazide--its pharmacological and immunosuppressive activity.
The authors investigated the immunological and pharmacological activity of l-cysteine hydrazide. It was found, that the preparation exhibited an interesting immunosuppressive and anti-inflammatory effect, which was evoked by the interference of the drug in nucleic acids and by stabilization of the cell membranes. Moreover it diminished the number of T lymphocytes. L-cysteine hydrazide showed no significant side effects. The authors discussed the possibility of its application in clinical therapy.
D000698:Analgesia; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000188:drug therapy; D003545:Cysteine / Q000031:analogs & derivatives* / Q000276:immunology / Q000633:toxicity; D004285:Dogs; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; C025196:cysteine hydrazide; D003545:Cysteine