[Effect of estrogens on the development of the leukocyte migration inhibition reaction in vitro in malignant neoplasms].
Effect of estron and estradiol hormones on the blood leukocyte migration inhibition test was studied in vitro. Blood autoplasm and water-salt extracts from the gastric tumour tissue were used as antigens. Marked inhibition of the blood leukocyte migration was noted in the majority of oncological patients in the presence of homologous tumour antigens or blood autoplasm. The effect of leukocyte migration inhibition was eliminated if leukocytes were preliminary incubated with estrogens, and then washed, or if the hormones were introduced into the medium together with the autoplasm or with the extracts from the tumour homologous tissue. It is suggested that estrogens block the antigen receptors on T-lymphocytes.
D000951:Antigens, Neoplasm / Q000276:immunology; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D003864:Depression, Chemical; D004958:Estradiol / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008222:Lymphokines / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm; D008222:Lymphokines; D004970:Estrone; D004958:Estradiol
Vliianie éstrogenov na razvitie reaktsii tormozheniia migratsii leĭkotsitov krovi in vitro pri zlokachestvennykh novoobrazovaniiakh.