Treatment of spasmodic torticollis with amantadine: a double-blind study.
Ten patients with spasmodic torticollis participated in a double-blind crossover trial of amantadine hydrochloride for a period of 2 months each. A further regimen of combined amantadine and haloperidol was tried with three patients after the conclusion of the double-blind trial. There were no therapeutic benefits of either treatment. Half of the patients reported minor side effects that resolved promptly when amantadine was discontinued.
D000328:Adult; D000368:Aged; D000547:Amantadine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D014103:Torticollis / Q000188:drug therapy*
D010919:Placebos; D000547:Amantadine; D006220:Haloperidol