[Suppression of antibody formation by bone marrow T-cells activated by histocompatibility antigens].
The suppressive effect of the bone marrow T-cells activated by histocompatibility antigens on antibody formation was studied. The bone marrow of CBA mice was found to contain the thymus-dependent lymphocytes which underwent hyperactivation after the repeated transfers to F1 recipients and acquired the capacity ot inhibit the development of cooperative immune response to sheep erythrocytes. Pretreatment of the bone marrow cells with antithymocyte globulin and complement prevented the suppression.
D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003165:Complement System Proteins; D006649:Histocompatibility Antigens; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation
D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens; D003165:Complement System Proteins
Supressiia antitelogeneza kostnomozgovymi T-kletkami, aktivirovannymi antigenami gistosovmestimosti