Cimetidine-induced neutropenia: a possible dose-related phenomenon.
Neutropenia associated with high-dose cimetidine therapy developed in a patient in whom earlier therapy, as well as rechallenge with low-dose cimetidine, did not result in neutropenia. As other factors cannot be implicated, a dose-related toxicity of cimetidine appears likely. Although the mechanism of cimetidine-induced neutropenia is unknown, it may involve the previously demonstrated ability of histamine H2 receptor antagonists to block the histamine-induced initiation of DNA synthesis in bone marrow stem cells.
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*
D006146:Guanidines; D002927:Cimetidine