Myasthenia gravis and lymphoma. A clinical and immunological association.
Myasthenia gravis and lymphoma rarely coexist, but the occurrence of myasthenia shortly after the treatment of a patient with poorly differentiated nodular lymphoma suggested that an immunological disorder may have contributed to the development of both diseases; the fundamental defects in this association may be impaired immunological surveillance and impaired regulation of immune responses to autoantigens. The finding of T-cell immunodeificiency, including profound T-cell lymphopenia, impaired delayed hypersensitivity responses, and failure to a thymus-dependent antibody response to Salmonella adelaide flagellin, is consistent with this hypothesis.
D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000276:immunology; D006801:Humans; D007157:Immunologic Surveillance; D008223:Lymphoma / Q000150:complications / Q000276:immunology* / Q000532:radiotherapy; D008231:Lymphopenia / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology; D009157:Myasthenia Gravis / Q000209:etiology / Q000276:immunology*; D011879:Radiotherapy Dosage; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens