Relationships among differentiated T-cell subpopulations. V. T-cell dependent mechanism of xenograft rejection and its radioresistant nature.
Rat tumours grew progressively in nu/nu mice but not in nu/+ mice, normal AKR mice or sublethally irradiated AKR mice after subcutaneous inoculation. Suppression of tumour growth appeared to depend on radioresistant cytotoxic T cells which were detected in in vivo neutralization tests (Winn's test) with spleen cells of mice immunized with rat lymphocytes or tumour cells 5 days previously. Radioresistant cytotoxic activity was detected by 51Cr-release test in glass-non-adherent peritoneal exudate cells 5 days after intraperitoneal immunization with rat lymphocytes. These results suggested that immune lymphocytes might differentiate to mature cytotoxic cells at the site of direct graft rejection.
D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001202:Ascitic Fluid / Q000276:immunology; D002448:Cell Adhesion; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D003602:Cytotoxicity, Immunologic; D005260:Female; D006084:Graft Rejection / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011835:Radiation Protection; D051381:Rats; D013154:Spleen / Q000528:radiation effects; D013601:T-Lymphocytes / Q000145:classification* / Q000166:cytology / Q000276:immunology; D014183:Transplantation, Heterologous
D000961:Antilymphocyte Serum