Serotonin-norepinephrine interactions in the tremorolytic actions of phenoxybenzamine and trazodone.
Phenoxybenzamine (5 mg/kg IP) and trazodone (5 mg/kg IP) reduced tremors produced in mice by administration of oxotremorine (10 mg/kg), harmaline (80 mg/kg), catechol (60 mg/kg), kepone (200 mg/kg) and clonidine (100 mg/kg). Azapetine (10 mg/kg IP) in combination with L-5-hydroxytryptophan (50 mg/kg IP) reduced the tremor induced by oxotremorine, catechol, kepone and clonidine. In mice with lower thoracic spinal cord transection, phenoxybenzamine and trazodone reduced catechol-induced tremor above and below the site of transection. These findings suggest that an alpha noradrenergic-serotonergic neuronal balance in the spinal cord may modulate tremors of different etiologies.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000502:physiology*; D010643:Phenoxybenzamine / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology; D014196:Trazodone / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced / Q000503:physiopathology*
D010879:Piperazines; D010643:Phenoxybenzamine; D012701:Serotonin; D006916:5-Hydroxytryptophan; D009638:Norepinephrine; D014196:Trazodone