Immunoregulation by covalent antigen-antibody complexes. II. Suppression of a T-cell independent anti-hapten response.
Covalent antigen-antibody complexes containing the hapten fluorescein were found to suppress the thymus-independent response to that hapten. This suppression required the presence of an intact Fc fragment in the complex but could still be established in the complete absence of T cells.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D004306:Dose-Response Relationship, Immunologic; D005452:Fluoresceins / Q000276:immunology; D006241:Haptens / Q000276:immunology*; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D005452:Fluoresceins; D006241:Haptens; D007141:Immunoglobulin Fc Fragments