[T-cell-antigen positive, E-rosette negative acute lymphoblastic leukaemia (author's transl)].
The lymphoblasts from 100 patients with acute lymphocytic leukaemia were investigated for the expression of receptors for sheep erythrocytes (E) and of a specific heterologous T cell antigen (T). In 17 cases, both T cell markers were expressed simultaneously on the leukaemic cells. In 13 cases only T antigens could be demonstrated on the lymphoblasts. A quantitative analysis of T antigens by immunoautoradiography revealed that the T expression of E-T+ -lymphoblasts was in general like that of E+T+-lymphocytes in the blood of normal persons, in several cases even higher. Therefore, the failure of E-rosette formation cannot be correlated to a decrease of the other T cell differentiation marker. In 7 out of 9 tested cases, a strong acid phosphatase reaction product located paranuclearly could be demonstrated. Complement-receptors were expressed in 3 of 5 cases which were also demonstrated in some cases of the E+T+-ALL group. The latter group was characterized by a T antigen expression like that of thymocytes. 4 cases of the E-T+ALL group were adults. Since the leukaemia cells of 2 cases were negative for acid phosphatase, PAS and all surface markers including cALL antigen, the T antigen can classify undifferentiated and otherwise unclassificable leukaemias. The clinical signigicance of the E-T+-ALL seems to be important since 5 out of 9 children with this type of ALL died soon after diagnosis.
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008297:Male; D011955:Receptors, Drug; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm; D003176:Complement C3; D011955:Receptors, Drug
T-Zell-Antigen positive, E-Rosetten negative akute Lymphoblastenleukämie.