title: Cellular parameters of the immunological memory induced by lysozyme-LPS mixtures and complexes.
abstract: The primary antibody response to the protein antigen lysozyme can be enhanced many fold by complexing the antigen with lipopolysaccharide (LPS). This complex, as well as lysozyme/LPS admixtures, is also capable of inducing a state of lysozyme specific immunological memory. Investigation of this memory state has revealed that administration of lysozyme either admixed or complexed with LPS results in priming of both B and T lymphocytes. Adoptive transfer of secondary responsiveness from animals primed in either fashion was further found to be T cell dependent. The implications of these findings are discussed.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007156:Immunologic Memory; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D009113:Muramidase / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D008070:Lipopolysaccharides; D009113:Muramidase