title: Two main features of T-cell development: thymus traffic and postthymic maturation.
abstract: It appears from the results presented in Table V and discussed in the preceding pages that a precursor population of immunologically competent T cells can be characterized and defined by multiple biological criteria as being probably of postthymic origin and substantially different from either the immunologically competent T lymphocyte or the prethymic stem cells. On the basis of recent data on functional characteristics of of different subsets of T cells, which suggest parallel lines of differentiation (see Chapter 2), it is possibile that the postthymic precursor compartment may also show heterogeneity; however, this cannot be presently asserted from our results.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000941:Antigens; D000961:Antilymphocyte Serum; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002465:Cell Movement; D002470:Cell Survival; D006410:Hematopoiesis; D006854:Hydrocortisone / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D011947:Receptors, Antigen, B-Cell; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013934:Thymectomy; D013950:Thymus Gland / Q000166:cytology* / Q000637:transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D000941:Antigens; D000961:Antilymphocyte Serum; D011947:Receptors, Antigen, B-Cell; D006854:Hydrocortisone