Cell-mediated immunity in experimental Nocardia asteroides infection.
Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
D000818:Animals; D002464:Cell Migration Inhibition; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology; D008297:Male; D009617:Nocardia Infections / Q000276:immunology*; D009616:Nocardia asteroides; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous