Late acting T cell depression of high avidity IgG antibody secretion in the secondary response.
Activated T lymphocytes (ATC) suppressed the expression of high avidity plaque-forming cells (PFC) in the secondary immune response when given in vivo 1 day before assay or when mixed in vitro with hyperimmune cells for 90 min before assay. This late acting suppression is a cell dose-dependent, carrier-spedific, T cell-mediated phenomenon. The target of this activity if probably the antibody-secreting cell.
D000818:Animals; D000941:Antigens; D004306:Dose-Response Relationship, Immunologic; D006433:Hemocyanins / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D051379:Mice; D008806:Mice, Inbred AKR; D010047:Ovalbumin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D010047:Ovalbumin; D006433:Hemocyanins