Relative efficiencies of a series of square-planar plantinum(II) compounds on Salmonella mutagenesis.
Twelve Pt(II) compounds have been tested for mutagenicity on Salmonella typhimurium (strain TA 100). Very high mutagenic activities were found for the cis derivatives. A correlation is suggested between these results and a formerly described model of chemical reactivity towards DNA, according to which cis derivatives from intra-strand chelates with guanine. A smaller activity was found with monodentate complexes with DNA.
D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D002945:Cisplatin / Q000494:pharmacology; D004269:DNA, Bacterial / Q000378:metabolism; D008968:Molecular Conformation; D009153:Mutagens; D010984:Platinum / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
D004269:DNA, Bacterial; D009153:Mutagens; D010984:Platinum; D002945:Cisplatin