Effects of testosterone undecanoate administration on LH and FSH response during the standard LH-RH test in healthy male volunteers.
The effects of orally administered testosterone undecanoate (TU) on the pituitary responsiveness to the intravenous injection of 100 microgram of synthetic LH-RH were studied in 10 young healthy male subjects. They were given TU in a daily dose of 160 mg for 14 days. The LH-RH Test was performed before the medication, on day 14, and on the 7th day of the post-treatment phase. Pituitary responsiveness remained normal throughout the whole study. A somewhat lower response for LH was observed in the post-treatment phase, most probably attributable to the increased baseline plasma testosterone levels.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone