A clinical comparison of tilidine hydrochloride and pentazocine, given orally for the treatment of postoperative pain.
A controlled, double-blind study involving 250 women was carried out ot assess the efficacy of oral tilidine 25, 50 and 100 mg in treating postepisiotomy pain, and to offer a comparison with oral pentazocine 50 mg. All the analgesics produced significant pain relief. At peak effect tilidine 50 mg produced very similar results to pentazocine 50 mg with tilidine 25 mg producing less, and tilidine 100 mg more pain relief. These results were not, however, statistically significant. In these postdelivery ambulant patients pentazocine 50 mg and tilidine 100 mg produced at 25% incidence of side-effects, mainly dizziness and drowsiness, but tilidine 25 mg produced significant analgesia with virtually no side-effects.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D002986:Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000008:administration & dosage* / Q000627:therapeutic use; D013993:Tilidine / Q000008:administration & dosage* / Q000627:therapeutic use; D014844:Vulva / Q000601:surgery
D003509:Cyclohexanecarboxylic Acids; D013993:Tilidine; D010423:Pentazocine