title: Immunologic abnormalities in patients with malignant lymphoproliferative diseases.
abstract: The B- and T-lymphocyte distribution was studied in 45 patients with malignant lymphoproliferative diseases. Eight patients with untreated Hodgkin's disease had normal mean percentages of complement receptor lymphocyte (CRL) cells and T-cells; however, the mean absolute number of T-cells was decreased. T-lymphocytes were also decreased in 3 patients with Hodgkin's disease treated 7-24 months previously. The number of T-lymphocytes increased markedly in all patients after treatment. Lymphocyte surface markers in non-Hodgkin's lymphoma showed distinctive patterns. Patients with leukemic reticuloendotheliosis or "hairy cell leukemia" characteristically had low percentages of CRL but normal or increased percentages of surface immunoglobulin-positive lymphocytes. The mean percentage and number of T-lymphocytes in this group were normal. Eight patients with nodular lymphocytic lymphoma and 2 patients with nodular lymphocytic-histiocytic lymphoma had normal mean numbers of CRL but decreased numbers of T-lymphocytes. Of 6 patients with diffuse lymphocytic lymphoma, 4 had elevated percentages and numbers of CRL. Despite low percentages, normal numbers of T-lymphocytes were found in 3 of these patients.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007958:Leukocyte Count; D008206:Lymphatic Diseases / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D008297:Male; D011947:Receptors, Antigen, B-Cell; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011947:Receptors, Antigen, B-Cell; D003165:Complement System Proteins