Lymhocyte stimulatory effect of an ether-extracted preparation of Brucella abortus.
The effect of a Brucella abortus preparation (Bru Pel) on the T- and B-lymphocyte populations is described. Bru Pel treatment of tumor-bearing mice resulted in a slight reduction in tumor size, marked splenomegaly, and statistically significant reductions in the percentages of splenic T and B lymphocytes relative to untreated tumor controls. Bru Pel was also found to cause increases in the incorporation of 3H-thymidine of phytohemagglutinin-sensitive splenic T lymphocytes and lipopolysaccharide-sensitive splenic B lymphocytes over 3H-thymidine-incorporated values for untreated tumor controls.
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D002004:Brucella Vaccine / Q000494:pharmacology*; D002330:Carmustine / Q000494:pharmacology; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000628:therapy; D013154:Spleen / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
D002004:Brucella Vaccine; D002330:Carmustine