[Clinical value of the study of myocardial blood flow by the method of Xe133 clearance in ischemic heart disease].
The clearance of intracoronarily introduced 133Xe was employed in investigating the myocardial blood flow in 105 patients, 10 of whom--controls and 95 suffering from various manifestations of ischemic heart disease. Use was made of the biexponential calculation of the clearance curve by taking account of the fast (circulation in normal tissues) and slow exponent (circulation along the cicatricially-altered sections of the myocardium) contributions to the common "effective" myocardial blood flow. In patients with ischemic heart disease a reduction of the myocardial blood flow depending upon the severity of the clinical picture and the degree of the coronary arteries lesion was revealed. A direct correlational dependence between the initial state of the myocardial circulation at rest and the level of the physical efforts tolerance was educed. A conclusion is drawn that the determination of the myocardial circulation by the method of the 133Xe clearance following intracoronarily administration of the substance should be done by taking account of the slow and fast exponents of the clearance curve, these exponents reflecting the circulation in sections of the myocardium differing in their functional activity.
D000328:Adult; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D011865:Radioisotope Dilution Technique / Q000379:methods*; D014978:Xenon
D014978:Xenon
Klinicheskaia tsennost' issledovaniia miokardial'nogo krovotoka metodom klirensa 133 Xe u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.