Gene expression in mitochondria and bacteria.
Mitochondria and bacteria possess protein synthesizing machineries which are similar in many respects; The regulation of gene expression in mitochondria is unknown. We, therefore, tried to use a well-established prokaryotic regulatory system for the exploration of mitochondrial gene regulation. DNA of the bacterial virus can be used as a template for gene expression in a mitochondrial in vitro system. The gene directed enzyme synthesis in the mitochondrial system is the basis for a study of regulation in mitochondrial protein synthesis.
D002701:Chloramphenicol / Q000494:pharmacology; D002874:Chromosome Mapping; D003090:Coliphages / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005796:Genes; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism; D013698:Templates, Genetic; D014158:Transcription, Genetic / Q000187:drug effects; D014779:Virus Replication
D004272:DNA, Mitochondrial; D002701:Chloramphenicol