Chemoimmunotherapy of cancer.
The preparation of a series of water-soluble mustard haptens for chemoimmunotherapy of cancer is described. Preliminary screening data are given, indicating some activity against P388 lymphocytic leukemia for those compounds containing the most potent immunogenic functional groups.
D000477:Alkylating Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D006084:Graft Rejection; D006241:Haptens; D007111:Immunity, Cellular / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D051379:Mice; D009150:Mustard Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D016038:Skin Transplantation; D012995:Solubility; D014184:Transplantation, Homologous
D000477:Alkylating Agents; D006241:Haptens; D009150:Mustard Compounds