Radiovaccine of S. typhimurium cells.
Gamma-irradiation of S. typhimurium cells up to a dose of 500 krad significantly reduces their toxicity. However, the antigenicity of these cells is not altered, which suggests that these cells could be used as a vaccine. The protection offered by the irradiated cells is comparable to that of formalin-treated cells. The radio-vaccine, however, offers an additional advantage of significant detoxification of the endotoxin, thereby minimizing side effects. The lipopolysaccharide extracted from the irradiated S. typhimurium cells offered cross-protection against other Salmonella species tested.
D000818:Animals; D001428:Bacterial Vaccines; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D051379:Mice; D051381:Rats; D012480:Salmonella Infections / Q000517:prevention & control; D012486:Salmonella typhimurium / Q000276:immunology / Q000528:radiation effects*; D014613:Vaccines, Attenuated
D001428:Bacterial Vaccines; D003037:Cobalt Radioisotopes; D014613:Vaccines, Attenuated