title: [Immunopathological findings in herpes gestationis (author's transl)].
abstract: Herpes gestationis occurred in a 26-year-old woman during the last weeks of her second pregnancy. Within 8 days of the delivery the disease had progressed to such an extent that systemic treatment became necessary. Whereas pre-delivery treatment had consisted exclusively of local desinfection, and steroid and antibiotic ointments, treatment after delivery also included systemic use of prednisolone. After treatment for 3 weeks the skin changes had disappeared except for minimal pigmentation. Using immunofluorescent microscopy a complement activation in the dermo-epidermal junction and in adjacent clinically healthy skin could be demonstrated: There were massive linear depositions of C3, C1q and C4. In the basal membrane of the epidermis IgM could be demonstrated as an unusual finding. Further immunopathological features were found in the form of an immune complex vasculitis which could be shown during the active phase of the disease.
mesh_terms: D000328:Adult; D001485:Basement Membrane; D003172:Complement C1 / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008856:Microscopy, Fluorescence; D006559:Pemphigoid Gestationis / Q000188:drug therapy / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
chemical_list: D003172:Complement C1; D003176:Complement C3; D003181:Complement C4; D007075:Immunoglobulin M; D003165:Complement System Proteins; D011239:Prednisolone
vernacular_title: Immunpathologische Befunde beim Herpes gestationis.