Clindamycin and colitis: a review.
Many studies have shown that clindamycin may cause pseudomembranous colitis, a potentially fatal complication. At present, prevention of this complication depends on (1) prescription of the drug only for specific severe infections, (2) early investigation and discontinuation of clindamycin if diarrhea ensues, and (3) vigorous supportive therapy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002792:Cholestyramine Resin / Q000627:therapeutic use; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects*; D003106:Colon / Q000473:pathology; D003967:Diarrhea / Q000139:chemically induced; D004157:Diphenoxylate / Q000627:therapeutic use; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged
D002792:Cholestyramine Resin; D002981:Clindamycin; D004157:Diphenoxylate