Enlargement of subarachnoid spaces and lateral ventricles in pediatric patients undergoing chemotherapy.
This retrospective study investigated the possible adverse effects of cancer therapy on the brain. Cranial computed tomographic scans of 76 patients with non-central nervous system malignancies and 25 patients with leukemia had enlarged lateral ventricles and/or cortical sulci in 19% and 40%, respectively. Leukemic patients, especially those with meningeal involvement, had the most frequent and most severe abnormalities.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D014695:Cerebral Ventriculography; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000188:drug therapy*; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D007951:Leukemia, Myeloid / Q000188:drug therapy; D012189:Retrospective Studies; D013346:Subarachnoid Space / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents