Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia.
Ecto-5'-nucleotidase activity was measured in lymphocyte subpopulations isolated from normal subjects and patients with congenital X-linked agammaglobulinemia. B lymphocytes from normal subjects have at least three times more ecto-5'-nucleotidase activity than T lymphocytes. Patients with X-linked agammaglobulinemia have 56% of normal activity in their T cells, and lack a lymphocyte subpopulation high in nucleotidase activity. High activity of ecto-5'-nucleotidase may be a biochemical marker for mature surface immunoglobulin-bearing B cells.
D000361:Agammaglobulinemia / Q000201:enzymology* / Q000235:genetics; D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D009439:Neuraminidase / Q000494:pharmacology; D009708:Nucleotidases; D011947:Receptors, Antigen, B-Cell; D012397:Rosette Formation; D012730:Sex Chromosomes; D012756:Sheep; D013601:T-Lymphocytes / Q000201:enzymology*; D014960:X Chromosome
D011947:Receptors, Antigen, B-Cell; D009708:Nucleotidases; D009439:Neuraminidase