The conjunctival sickling sign, hemoglobin S, and irreversibly sickled erythrocytes.
Sixty-five patients with hemoglobins AS, SC, and SS were investigated in a masked fashion. We observed a statistically significant positive correlation between the severity of conjunctival sickling signs and the counts of irreversibly sickled cells in each hemoglobinopathy group. We also observed a statistically significant positive correlation between the severity of the conjunctival vasculopathy and the percentage of sickle hemoglobin in the total group of patients with hemoglobins AS, SC, and SS.
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D002648:Child; D002986:Clinical Trials as Topic; D003228:Conjunctiva / Q000098:blood supply*; D004903:Erythrocyte Aggregation; D004906:Erythrocyte Count; D004913:Erythrocytes, Abnormal / Q000032:analysis; D005132:Eye Manifestations; D006451:Hemoglobin, Sickle / Q000032:analysis; D006452:Hemoglobinometry; D006579:Heterozygote; D049671:History, 18th Century; D006720:Homozygote; D006801:Humans; D008875:Middle Aged
D006451:Hemoglobin, Sickle