Changes in sensitivity of mice to anticonvulsant drugs following bilateral olfactory bulb ablations.
Changes in sensitivity to anticonvulsant drugs were investigated after bilateral olfactory bulb ablations in mice. The sensitivity to benzodiazepines and acetazolamide increased, whereas that to phenylacetylurea and dipropylacetic acid decreased, and sensitivity to phenobarbital, diphenylhydantoin and trimethadion was not significantly changes after olfactory bulb ablations. Increase in sensitivity to benzodiazepines was the most significant in both electroshock and pentetrazol convulsions. It was suggested that altered activities and denervation supersensitivity in the limbic system, hypothalamus and midbrain might account for these changes in sensitivity to anticonvulsant drugs after olfactory bulb ablations.
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D051379:Mice; D009567:Nitrazepam / Q000494:pharmacology; D009830:Olfactory Bulb / Q000502:physiology* / Q000601:surgery; D010634:Phenobarbital / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D014293:Trimethadione / Q000494:pharmacology; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology; D014635:Valproic Acid / Q000494:pharmacology
D000927:Anticonvulsants; D010648:Phenylacetates; D014635:Valproic Acid; D010672:Phenytoin; D002707:Chlordiazepoxide; D014508:Urea; D009567:Nitrazepam; D000086:Acetazolamide; D003975:Diazepam; D014293:Trimethadione; D010634:Phenobarbital