The antipyretic effect of UP 517-03 in the rabbit.
The antipyretic effect of UP 517-03 was studied in rabbits, provided with a cannula in the lateral cerebral ventricle. Given orally as a curative treatment, UP 517-03 can abolish hyperthermic reactions induced by intracerebroventricular injection of sodium arachidonate or bacterial endotoxin. A comparison with acetylsalicylic acid and indomethacin is given. UP 517-03 does not modify the temperature of normothermic rabbits. These results suggests that the antipyretic action of UP 517-03 can be explained by an effect of this substance on the metabolism of arachidonic acid in brain.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004731:Endotoxins / Q000037:antagonists & inhibitors; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011422:Propionates / Q000494:pharmacology*; D011817:Rabbits; D012475:Salmonella
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D004731:Endotoxins; D007189:Indans; D007192:Indenes; D011422:Propionates; C024536:2-(2-isopropyl-5-indanyl)propionic acid; D001241:Aspirin; D007213:Indomethacin