Gamma A myeloma with hyperviscosity and obstructive uropathy.
A patient with gamma A myeloma, hyperviscosity and an obstructive uropathy is described. Operation revealed a proteinaceous mass obstructing the right renal pelvis. Immunoprecipitin and immunofluorescent analysis of this mass and concentrated urine demonstrated the presence of gamma A myeloma protein, kappa light chains and albumin. This is the first description of an obstructive uropathy in multiple myeloma owing to a proteinaceous matrix containing paraprotein.
D001809:Blood Viscosity; D001859:Bone Neoplasms / Q000150:complications*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000032:analysis; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D009194:Myeloma Proteins / Q000032:analysis; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology
D007070:Immunoglobulin A; D009194:Myeloma Proteins