Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study.
We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized, double-blind, prospective plan. There was no difference in the short-term or long-term function of either group of kidneys. Allopurinol does not appear to have as consistent a beneficial effect on non-ischemically damaged human kidneys as that observed experimentally on ischemically damaged canine organs.
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D002102:Cadaver; D002986:Clinical Trials as Topic; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods; D014021:Tissue Preservation / Q000379:methods*; D014185:Transplantation, Isogeneic
D000493:Allopurinol