title: The enterohepatic circulation of conjugated bile acids in healthy man: quantitative description and functions.
abstract: A multicompartmental model describing the enterohepatic circulation of conjugated bile acids in man under steady-state conditions is proposed. The model encompasses conjugation; deconjugation and reconjugation; dehydroxylation; sulfation, desulfation and resulfation; dehydrogenation; and stereoselective rehydrogenation. A dynamic description of the enterohepatic circulation and a brief description of bile acid functions in health and dysfunctions in disease are also discussed.
mesh_terms: D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D001665:Binding Sites; D002769:Cholelithiasis / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002793:Cholic Acids / Q000378:metabolism; D002940:Circadian Rhythm; D003840:Deoxycholic Acid / Q000378:metabolism; D004764:Enterohepatic Circulation; D005243:Feces / Q000032:analysis; D005998:Glycine / Q000378:metabolism; D006801:Humans; D008095:Lithocholic Acid / Q000378:metabolism; D008954:Models, Biological; D010743:Phospholipids / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D002793:Cholic Acids; D010743:Phospholipids; D003840:Deoxycholic Acid; D008095:Lithocholic Acid; D002784:Cholesterol; D005998:Glycine