[Effect of proscillaridin-4'-methylether on pressure rise velocity in the left ventricle of patients with coronary heart disease (author's transl)].
In a randomized, controlled, double-blind study 2 groups of 7 patients each with coronary heart disease received either 1 mg methylproscillaridin (MP) a cardiac glycoside of the squill intravenously, or placebo to test the inotropic effect of MP. Pressures and dp/dt max were measured in the left ventricle before and after coronary angiography after an average of 62 min (60 to 70 min). There was a significant (p less than 0.05) increase of dp/dt max in the MP-group (Wilcoxon-Mann-Whitney test). Left ventricular enddiastolic pressure was decreased from 16.1 to 13.6 mm Hg in the MP-group, and increased in theplacebo group from 12 to 13.7 mm Hg (mean values). Thus, a positive inotropic effect of the glycoside may be assumed.
D000792:Angiography; D001794:Blood Pressure / Q000187:drug effects*; D002018:Bufanolides / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D017023:Coronary Angiography; D003327:Coronary Disease / Q000503:physiopathology*; D004311:Double-Blind Method; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D010919:Placebos; D011442:Proscillaridin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D002018:Bufanolides; D010919:Placebos; D011442:Proscillaridin
Die Wirkung von Proscillaridin-4'-methyläther auf die maximale Druckanstiegsgeschwindigkeit im linken Ventrikel von Patienten mit Coronarinsuffizienz.