Macrophage tumor killing: influence of the local environment.
Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.
D001500:BCG Vaccine; D001769:Blood; D002478:Cells, Cultured; D003470:Culture Media; D004731:Endotoxins / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology; D014357:Trypsin / Q000378:metabolism
D001500:BCG Vaccine; D003470:Culture Media; D004731:Endotoxins; D004791:Enzyme Inhibitors; D008222:Lymphokines; D014357:Trypsin