Defective neutrophil chemotaxis and raised serum ige levels in a child with recurrent bacterial infections and eczema. Influence of levamisole.
A 5 1/2-year-old girl, with a life-long history of recurrent staphylococcal infections and eczematous dermatitis had a defect in polymorphonuclear leucocyte chemotaxis and phagocytosis in autologous serum, a high serum IgE level, and a disturbed T cell function. Levamisole improved all the immunological abnormalities and there was a dramatic clinical improvement. Discontinuation of therapy with levamisole resulted in gradual deterioration.
D002634:Chemotaxis, Leukocyte; D002648:Child; D004485:Eczema / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007978:Levamisole / Q000627:therapeutic use; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007978:Levamisole; D007073:Immunoglobulin E