[High-dose methotrexate/leucovorin adjuvant chemotherapy of osteogenic sarcoma: biochemical effects in DNA-synthesis of bone marrow cells (author's transl)].
DNA metabolism in bone marrow cells was measured under high-dose Methotrexate/Leucovorin adjuvant chemotherapy of a patient with primary amputation of his right leg because of osteogenic sarcoma. The biochemical data showed that there was no rescue effect of Leucovorin after 200 mg/kg Methotrexate. Corresponding to this "biochemical failure" of the rescue effect the patient died from the complications of a long and very severe bone marrow suppression. To improve the safety of this therapeutic regimen the intravenous injection and in some cases a higher dose of Leucovorin is recommended.
D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D001859:Bone Neoplasms / Q000188:drug therapy*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D012516:Osteosarcoma / Q000188:drug therapy*
D004247:DNA; D002955:Leucovorin; D008727:Methotrexate
Adjuvante Chemotherapie des osteogenen Sarkoms mit High-Dose Methotrexat/Leucovorin: Biochemische Effekte auf die DNA-Synthese der Knochenmarkzellen.