[Comparative study of the physicochemical properties of the surface of Escherichia, their sensitivity to ampicillin and tetracycline and their capacity to absorb tetracycline].
Development of resistance to ampicillin and tetracycline in Escherichia resulted in an increase in the electrokinetic potential and a decrease in the level of hydration and isoelectric values of pH. The changes in the hydration level mainly depended on the accompanying dissociation. Studies on 3H-tetracycline binding revealed a low accumulation capacity of the resistant mutants. The rate of 3H-tetracycline binding did not depend on the changes in the physico-chemical parameters of the cell surface due to resistance and dissociation.
D000042:Absorption; D000667:Ampicillin / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007526:Isoelectric Point; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013499:Surface Properties; D013752:Tetracycline / Q000378:metabolism / Q000494:pharmacology*; D014316:Tritium
D014316:Tritium; D000667:Ampicillin; D013752:Tetracycline
Sravnitel'noe izuchenie fiziko-khimicheskikh svoĭstv poverkhnosti ésherikhiĭ, ikh chuvstvitel'nost' k ampitsillinu i tetratsiklinu i sposobnost' pogloshchat' tetratsiklin