Use of the Ommaya reservoir in the prevention and treatment of CNS leukemia.
Insertion of an indwelling ventricular cannula via the transfrontal approach by the method described, and the use of an attached reservoir is a safe technique in the hands of experienced personnel. Intraventricular chemotherapy prolongs the duration of remission in those individuals who have evidence of meningeal leukemia. The superiority of this method over intralumbar therapy as a preventive measure has not been demonstrated.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002408:Catheters, Indwelling; D002493:Central Nervous System Diseases / Q000517:prevention & control*; D014695:Cerebral Ventriculography / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007276:Injections, Intraventricular / Q000009:adverse effects / Q000379:methods*; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use
D000970:Antineoplastic Agents; D003561:Cytarabine; D008727:Methotrexate