Myocardial positron tomography with manganese-52m.
The biodistribution of radiomanganese (54Mn) was studied in mice, rats, and dogs. Disappearance of radioactivity from the blood was extremely rapid, with a half-time of approximately 0.8 minutes. This resulted in very favorable myocardium-to-blood ratios, even at early times after administration. The myocardial uptake in dogs was greater than 3% at three and 15 minutes, with myocardium-to-blood ratios of about 40:1 at 15 minutes. Positron tomograms obtained with 52mMn clearly demonstrated regional myocardial perfusion. There was good correlation (r = 0.89) of microsphere-to-radiomanganese distribution in the infarcted dog heart.
D000818:Animals; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging*; D008345:Manganese / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D011829:Radiation Dosage; D011868:Radioisotopes; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods*
D011868:Radioisotopes; D008345:Manganese