title: Utilization in vivo of glucose carbon in the optic lobes and the cerebellum of the chick during postnatal growth.
abstract: 1. The incorporation of glucose carbon in vivo into amino acids was studied in the chick optic lobes and cerebellum during postnatal growth after subcutaneous injection of [U-14C]glucose. 2. The rapid incorporation of glucose carbon into free amino acids appears between the 1st and the 2nd day of postnatal growth in the optic lobes and between the 1st and the 4th day after hatching in the cerebellum. 3. The period during which the properties of mature brain metabolism are obtained is characterized in both structures during the first 48 hr of postnatal growth by changes in the specific radioactivity of some amino acids such as aspartate and alpha-alanine, and also by transient increases of glucose and glutamine concentrations. 4. The gamma-aminobutyrate content in the optic lobes is very high; the cerebellum on the contrary is characterized by its low gamma-aminobutyrate concentration linked to a very fast metabolism of this amino acid.
mesh_terms: D000375:Aging; D000818:Animals; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D002645:Chickens; D005947:Glucose / Q000378:metabolism*; D003336:Tectum Mesencephali / Q000254:growth & development* / Q000378:metabolism
chemical_list: D005947:Glucose