[Effect of SITS (4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid) on the transport of chloride through the isolated skin of Rana esculenta].
The effect of SITS (6 . 10(-4)M on transepithelial potential (E) and short circuit current (I) of isolated frog skin has been studied either using Ringer or Cl- -depleted Ringer in the outside bathing solution. SITS affects the transepithelial potential (E) and the short-circuit current (I) only if normal Ringer is used and SITS is added in the outside bathing medium. The existence of a negative exchanging-charge carrier on the external membrane of the epithelial cells is postulated. This mechanism could be a step of the actively transported Cl- ions.
D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism*; D011893:Rana esculenta / Q000378:metabolism*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*
D002712:Chlorides; D013267:Stilbenes; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
Effetto del SITS (4-acetamido-4-'isothyocyano-2,2'-disulfonic-stilbene) sul trasporto di cloro attraverso la pelle isolata di rana esculenta.