title: The restriction endonuclease cleavage map of rat liver mitochondrial DNA.
abstract: Mitochondrial DNA from rat liver contains six sites for cleavage by the restriction endonucleases Hind III and EcoRI. A large stretch of DNA, comprising about 40% of the mitochondrial genome is not cleaved by either of the enzymes; eight cleavage sites are located on a DNA stretch of 35% of the genome length suggestive of an unequal distribution of the A - T baspairs over the molecule. The number of Hind III and Eco R I fragments is much higher than reported for other mammalian mitochondrial DNAs up to now.
mesh_terms: D000818:Animals; D004262:DNA Restriction Enzymes; D004272:DNA, Mitochondrial; D004591:Electrophoresis, Polyacrylamide Gel; D004720:Endonucleases; D004926:Escherichia coli / Q000201:enzymology; D006193:Haemophilus influenzae / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000032:analysis*; D008970:Molecular Weight; D051381:Rats
chemical_list: D004272:DNA, Mitochondrial; D004720:Endonucleases; D004262:DNA Restriction Enzymes