title: [Structure and antipyretic-hypothermizing effect of various pyrazol/1,5-a/pyrimidines].
abstract: Structures of condensation products between 3-phenyl-5-aminopyrazole and ethyl ethoxymethylenacetoacetate and ethyl acetonoxalate are demonstrated, namely ethyl 2-phenyl-7-methylpyrazolo[1,5-a]pyrimidin-6-carboxylate and ethyl 2-phenyl-7-methylpyrazolo[1,5-a]pyrimidin-5-carboxylate. Studies on antipyretic and hypothermizing activity of the acid derived from the latter and of other compounds are reported.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D005334:Fever / Q000188:drug therapy; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D011743:Pyrimidines
vernacular_title: Struttura ed azione antipiretico-ipothermizzante di alcuni derivati pirazolo[1,5-a]pirimidinici.